pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1137-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 124 46 6,000 1,879E-09 4,59E-06 ! nuclear migration GO:0007097 13 6 3,000 6,668E-09 8,145E-06 ! interphase of mitotic cell cycle GO:0051329 224 98 7,000 2,007E-08 1,634E-05 ! apoptotic mitochondrial changes GO:0008637 42 20 4,000 2,972E-08 1,815E-05 ! regulation of lipid kinase activity GO:0043550 17 8 3,000 3,089E-08 1,509E-05 ! establishment of nucleus localization GO:0040023 18 8 3,000 3,089E-08 1,258E-05 ! negative regulation of cell size GO:0045792 144 69 6,000 3,463E-08 1,208E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 6,000 3,463E-08 1,057E-05 ! negative regulation of kinase activity GO:0033673 145 70 6,000 3,832E-08 1,04E-05 ! induction of positive chemotaxis GO:0050930 17 9 3,000 5,54E-08 1,353E-05 ! negative regulation of transferase activity GO:0051348 155 74 6,000 5,664E-08 1,258E-05 ! induction of apoptosis by intracellular signals GO:0008629 95 45 5,000 6,404E-08 1,304E-05 ! negative regulation of phosphorylation GO:0042326 52 24 4,000 8,028E-08 1,509E-05 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 4,000 1,233E-07 2,152E-05 GO:0045936|negative regulation of phosphate metabolic process, ! nucleus localization GO:0051647 22 11 3,000 1,441E-07 2,346E-05 ! insulin receptor signaling pathway GO:0008286 66 27 4,000 1,508E-07 2,302E-05 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 2,153E-07 3,094E-05 GO:0050927|positive regulation of positive chemotaxis, ! response to UV GO:0009411 120 55 5,000 2,194E-07 2,977E-05 ! regulation of cell cycle process GO:0010564 161 90 6,000 2,21E-07 2,842E-05 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 2,725E-07 3,328E-05 ! aging GO:0007568 112 58 5,000 3,028E-07 3,522E-05 ! cellular response to extracellular stimulus GO:0031668 52 31 4,000 3,126E-07 3,471E-05 ! response to peptide hormone stimulus GO:0043434 129 64 5,000 5,481E-07 5,822E-05 ! negative regulation of cell growth GO:0030308 142 67 5,000 7,212E-07 7,341E-05 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 8,995E-07 8,79E-05 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 9,756E-07 9,167E-05 ! cell cycle checkpoint GO:0000075 145 71 5,000 1,019E-06 9,223E-05 ! microspike assembly GO:0030035 46 18 3,000 1,302E-06 1,136E-04 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 5,000 1,919E-06 1,616E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 1,945E-06 1,584E-04 GO:0031272|regulation of pseudopodium assembly, ! response to hypoxia GO:0001666 178 81 5,000 2,223E-06 1,752E-04 ! response to oxygen levels GO:0070482 183 83 5,000 2,566E-06 1,959E-04 ! response to insulin stimulus GO:0032868 98 47 4,000 2,658E-06 1,968E-04 ! regulation of ligase activity GO:0051340 147 84 5,000 2,753E-06 1,978E-04 ! negative regulation of growth GO:0045926 168 85 5,000 2,95E-06 2,059E-04 ! positive regulation of cell cycle GO:0045787 96 48 4,000 2,956E-06 2,006E-04 ! cell aging GO:0007569 48 22 3,000 3,068E-06 2,026E-04 ! positive regulation of locomotion GO:0040017 44 22 3,000 3,068E-06 1,973E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 3,391E-06 2,124E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 3,391E-06 2,071E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 3,391E-06 2,021E-04 ! regulation of chemotaxis GO:0050920 45 23 3,000 3,701E-06 2,153E-04 ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 3,701E-06 2,103E-04 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 48 25 3,000 5,249E-06 2,914E-04 ! protein tetramerization GO:0051262 57 25 3,000 5,249E-06 2,85E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 2,000 5,408E-06 2,872E-04 ! regulation of DNA replication GO:0006275 105 56 4,000 6,399E-06 3,326E-04 ! leukocyte differentiation GO:0002521 232 98 5,000 6,756E-06 3,439E-04 ! cellular response to nutrient levels GO:0031669 45 27 3,000 7,229E-06 3,604E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 8,084E-06 3,95E-04 ! macrophage differentiation GO:0030225 15 9 2,000 8,084E-06 3,872E-04 ! establishment of organelle localization GO:0051656 122 59 4,000 8,293E-06 3,896E-04 ! regulation of mitosis GO:0007088 112 63 4,000 1,147E-05 5,287E-04 GO:0051783|regulation of nuclear division, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,151E-05 5,207E-04 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 1,151E-05 5,112E-04 ! response to nicotine GO:0035094 20 10 2,000 1,151E-05 5,021E-04 ! response to heat GO:0009408 54 31 3,000 1,278E-05 5,475E-04 ! positive regulation of cell motion GO:0051272 157 65 4,000 1,338E-05 5,635E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 1,577E-05 6,53E-04 ! thymus development GO:0048538 29 11 2,000 1,577E-05 6,421E-04 ! negative regulation of glucose import GO:0046325 18 11 2,000 1,577E-05 6,316E-04 GO:0010829|negative regulation of glucose transport, ! negative regulation of ligase activity GO:0051352 116 68 4,000 1,67E-05 6,579E-04 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 4,000 1,67E-05 6,474E-04 ! cell projection assembly GO:0030031 138 68 4,000 1,67E-05 6,373E-04 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 4,000 1,793E-05 6,74E-04 ! homeostasis of number of cells GO:0048872 131 69 4,000 1,793E-05 6,638E-04 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 2,096E-05 7,641E-04 ! regulation of B cell proliferation GO:0030888 22 12 2,000 2,096E-05 7,529E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 2,096E-05 7,42E-04 ! focal adhesion formation GO:0048041 37 12 2,000 2,096E-05 7,314E-04 ! T cell homeostasis GO:0043029 28 12 2,000 2,096E-05 7,211E-04 ! regulation of leukocyte migration GO:0002685 29 12 2,000 2,096E-05 7,11E-04 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 4,000 2,208E-05 7,388E-04 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 4,000 2,208E-05 7,289E-04 ! organelle localization GO:0051640 155 74 4,000 2,523E-05 8,218E-04 ! regulation of protein stability GO:0031647 77 38 3,000 2,922E-05 9,393E-04 ! positive regulation of ligase activity GO:0051351 130 77 4,000 3,06E-05 9,708E-04 ! mitotic cell cycle checkpoint GO:0007093 76 39 3,000 3,244E-05 1,016E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 3,444E-05 1,065E-03 ! response to gamma radiation GO:0010332 30 14 2,000 3,444E-05 1,052E-03 ! catecholamine biosynthetic process GO:0042423 30 14 2,000 3,444E-05 1,039E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 3,444E-05 1,026E-03 ! protein oligomerization GO:0051259 149 79 4,000 3,464E-05 1,02E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 4,148E-05 1,206E-03 ! negative regulation of bone remodeling GO:0046851 34 15 2,000 4,29E-05 1,233E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 4,29E-05 1,219E-03 ! lymphocyte homeostasis GO:0002260 33 15 2,000 4,29E-05 1,205E-03 ! T cell differentiation GO:0030217 93 42 3,000 4,367E-05 1,212E-03 ! response to metal ion GO:0010038 158 84 4,000 4,658E-05 1,279E-03 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 4,931E-05 1,338E-03 ! positive regulation of response to external stimulus GO:0032103 88 44 3,000 5,259E-05 1,412E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 2,000 5,262E-05 1,397E-03 ! mitochondrion organization GO:0007005 159 87 4,000 5,513E-05 1,448E-03 ! negative regulation of cell cycle process GO:0010948 35 17 2,000 6,368E-05 1,655E-03 ! filopodium assembly GO:0046847 42 17 2,000 6,368E-05 1,637E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 6,368E-05 1,62E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 6,368E-05 1,604E-03 ! response to inorganic substance GO:0010035 173 90 4,000 6,484E-05 1,616E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 4,000 7,582E-05 1,871E-03 GO:0010498|proteasomal protein catabolic process, ! cell-substrate junction assembly GO:0007044 56 18 2,000 7,615E-05 1,86E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 7,615E-05 1,842E-03 ! regulation of DNA metabolic process GO:0051052 188 97 4,000 9,263E-05 2,219E-03 ! response to temperature stimulus GO:0009266 84 51 3,000 9,439E-05 2,239E-03 ! response to alkaloid GO:0043279 38 20 2,000 1,057E-04 2,482E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 1,057E-04 2,458E-03 ! regulation of glucose import GO:0046324 30 20 2,000 1,057E-04 2,435E-03 GO:0010827|regulation of glucose transport, ! negative regulation of translation GO:0017148 32 20 2,000 1,057E-04 2,412E-03 ! positive regulation of growth GO:0045927 96 53 3,000 1,098E-04 2,484E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 1,229E-04 2,753E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 1,229E-04 2,728E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 1,27E-04 2,795E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 1,418E-04 3,092E-03 ! cellular response to starvation GO:0009267 37 22 2,000 1,418E-04 3,065E-03 ! G1 phase GO:0051318 44 22 2,000 1,418E-04 3,038E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 1,418E-04 3,012E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 2,000 1,418E-04 2,986E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 1,563E-04 3,263E-03 ! positive regulation of DNA replication GO:0045740 44 23 2,000 1,625E-04 3,364E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 1,625E-04 3,336E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 1,851E-04 3,767E-03 ! sex determination GO:0007530 48 24 2,000 1,851E-04 3,736E-03 ! platelet activation GO:0030168 41 24 2,000 1,851E-04 3,706E-03 ! DNA damage response, signal transduction GO:0042770 136 62 3,000 2,025E-04 4,022E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 2,096E-04 4,129E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 2,096E-04 4,096E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 2,096E-04 4,063E-03 ! vasculogenesis GO:0001570 49 25 2,000 2,096E-04 4,031E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 2,096E-04 4E-03 ! interaction with host GO:0051701 66 25 2,000 2,096E-04 3,969E-03 ! leukocyte homeostasis GO:0001776 50 25 2,000 2,096E-04 3,938E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 2,122E-04 3,958E-03 GO:0045844|positive regulation of striated muscle development, ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,122E-04 3,928E-03 ! protein maturation by protein folding GO:0022417 14 5 1,000 2,122E-04 3,898E-03 ! apoptotic cell clearance GO:0043277 23 5 1,000 2,122E-04 3,869E-03 ! lipoprotein particle clearance GO:0034381 10 5 1,000 2,122E-04 3,841E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,122E-04 3,812E-03 ! parathyroid gland development GO:0060017 14 5 1,000 2,122E-04 3,785E-03 ! anagen GO:0042640 7 5 1,000 2,122E-04 3,757E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 2,122E-04 3,73E-03 ! microvillus organization GO:0032528 8 5 1,000 2,122E-04 3,704E-03 GO:0030033|microvillus assembly, ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 1,000 2,122E-04 3,677E-03 ! response to food GO:0032094 6 5 1,000 2,122E-04 3,651E-03 ! positive regulation of transporter activity GO:0032411 8 5 1,000 2,122E-04 3,626E-03 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 2,122E-04 3,601E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,122E-04 3,576E-03 ! cellular glucose homeostasis GO:0001678 6 5 1,000 2,122E-04 3,551E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 2,122E-04 3,527E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,122E-04 3,503E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,122E-04 3,48E-03 ! regulation of leukocyte degranulation GO:0043300 8 5 1,000 2,122E-04 3,457E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,122E-04 3,434E-03 ! cellular response to nutrient GO:0031670 8 5 1,000 2,122E-04 3,411E-03 ! porphyrin catabolic process GO:0006787 12 5 1,000 2,122E-04 3,389E-03 GO:0033015|tetrapyrrole catabolic process, ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 2,122E-04 3,367E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,122E-04 3,345E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,122E-04 3,324E-03 ! sequestering of calcium ion GO:0051208 7 5 1,000 2,122E-04 3,303E-03 ! stem cell division GO:0017145 11 5 1,000 2,122E-04 3,282E-03 GO:0048103|somatic stem cell division, ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 2,29E-04 3,518E-03 ! molting cycle process GO:0022404 52 26 2,000 2,361E-04 3,605E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 2,361E-04 3,583E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 2,361E-04 3,56E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 2,579E-04 3,865E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 2,579E-04 3,842E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 2,647E-04 3,919E-03 ! mitochondrial membrane organization GO:0007006 60 27 2,000 2,647E-04 3,896E-03 ! response to starvation GO:0042594 47 27 2,000 2,647E-04 3,872E-03 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 3,000 2,733E-04 3,974E-03 ! myeloid cell differentiation GO:0030099 126 67 3,000 2,733E-04 3,95E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 2,955E-04 4,246E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 2,955E-04 4,221E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 2,955E-04 4,197E-03 ! urogenital system development GO:0001655 149 69 3,000 3,06E-04 4,321E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 3,174E-04 4,456E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 1,000 3,174E-04 4,431E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 1,000 3,174E-04 4,405E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 3,174E-04 4,381E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 3,174E-04 4,356E-03 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 3,174E-04 4,332E-03 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 3,174E-04 4,308E-03 ! hair follicle maturation GO:0048820 8 6 1,000 3,174E-04 4,284E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 3,174E-04 4,26E-03 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 1,000 3,174E-04 4,237E-03 ! regulation of mast cell activation GO:0033003 13 6 1,000 3,174E-04 4,214E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 3,174E-04 4,191E-03 ! triglyceride catabolic process GO:0019433 10 6 1,000 3,174E-04 4,169E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 3,174E-04 4,146E-03 ! germ cell development GO:0007281 133 70 3,000 3,234E-04 4,202E-03 ! catechol metabolic process GO:0009712 55 29 2,000 3,284E-04 4,245E-03 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 3,284E-04 4,223E-03 ! response to organic cyclic substance GO:0014070 58 29 2,000 3,284E-04 4,201E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 3,415E-04 4,345E-03 ! phenol metabolic process GO:0018958 56 30 2,000 3,637E-04 4,604E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 3,637E-04 4,58E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 3,637E-04 4,556E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 3,637E-04 4,533E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 2,000 3,637E-04 4,51E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 3,000 4E-04 4,936E-03 ! cell junction assembly GO:0034329 85 31 2,000 4,013E-04 4,926E-03 ! male gonad development GO:0008584 56 31 2,000 4,013E-04 4,902E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 4,013E-04 4,877E-03 ! regulation of transcription factor activity GO:0051090 137 75 3,000 4,211E-04 5,092E-03 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 3,000 4,211E-04 5,067E-03 ! metanephros development GO:0001656 81 32 2,000 4,413E-04 5,285E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 4,413E-04 5,259E-03 ! cell-matrix adhesion GO:0007160 181 76 3,000 4,429E-04 5,252E-03 ! lymphocyte differentiation GO:0030098 193 76 3,000 4,429E-04 5,227E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 4,43E-04 5,203E-03 ! prostate gland development GO:0030850 14 7 1,000 4,43E-04 5,178E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 4,43E-04 5,153E-03 ! mRNA stabilization GO:0048255 18 7 1,000 4,43E-04 5,129E-03 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 16 7 1,000 4,43E-04 5,105E-03 GO:0031958|corticosteroid receptor signaling pathway, ! lipoprotein transport GO:0042953 14 7 1,000 4,43E-04 5,081E-03 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 1,000 4,43E-04 5,057E-03 ! glycerol ether catabolic process GO:0044269 12 7 1,000 4,43E-04 5,033E-03 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 1,000 4,43E-04 5,01E-03 ! male sex determination GO:0030238 15 7 1,000 4,43E-04 4,987E-03 ! spindle checkpoint GO:0031577 16 7 1,000 4,43E-04 4,964E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 4,43E-04 4,942E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 4,43E-04 4,919E-03 ! regulation of meiosis GO:0040020 12 7 1,000 4,43E-04 4,897E-03 GO:0051445|regulation of meiotic cell cycle, ! negative regulation of nuclear division GO:0051784 15 7 1,000 4,43E-04 4,875E-03 GO:0045839|negative regulation of mitosis, ! peptidyl-threonine modification GO:0018210 26 7 1,000 4,43E-04 4,853E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 4,43E-04 4,831E-03 ! muscle adaptation GO:0043500 13 7 1,000 4,43E-04 4,81E-03 ! regulation of vesicle-mediated transport GO:0060627 136 77 3,000 4,654E-04 5,031E-03 ! response to ionizing radiation GO:0010212 74 33 2,000 4,838E-04 5,206E-03 ! leukocyte chemotaxis GO:0030595 55 33 2,000 4,838E-04 5,184E-03 GO:0060326|cell chemotaxis, ! blood coagulation GO:0007596 151 79 3,000 5,131E-04 5,473E-03 GO:0050817|coagulation, ! response to hydrogen peroxide GO:0042542 56 34 2,000 5,288E-04 5,617E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 5,288E-04 5,592E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 5,288E-04 5,568E-03 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 5,641E-04 5,914E-03 ! DNA damage checkpoint GO:0000077 78 35 2,000 5,764E-04 6,018E-03 ! positive regulation of endocytosis GO:0045807 56 35 2,000 5,764E-04 5,992E-03 ! biogenic amine biosynthetic process GO:0042401 65 35 2,000 5,764E-04 5,967E-03 ! placenta development GO:0001890 53 35 2,000 5,764E-04 5,942E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 5,888E-04 6,044E-03 ! glycerolipid catabolic process GO:0046503 14 8 1,000 5,888E-04 6,019E-03 ! pigment granule organization GO:0048753 17 8 1,000 5,888E-04 5,994E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 5,888E-04 5,969E-03 ! ER overload response GO:0006983 13 8 1,000 5,888E-04 5,944E-03 ! regulation of pigmentation during development GO:0048070 25 8 1,000 5,888E-04 5,92E-03 ! melanin metabolic process GO:0006582 17 8 1,000 5,888E-04 5,896E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 5,888E-04 5,872E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 5,888E-04 5,848E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 5,888E-04 5,824E-03 ! positive regulation of vasodilation GO:0045909 14 8 1,000 5,888E-04 5,8E-03 ! negative regulation of translational initiation GO:0045947 12 8 1,000 5,888E-04 5,777E-03 ! response to UV-B GO:0010224 17 8 1,000 5,888E-04 5,754E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 5,888E-04 5,731E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 5,888E-04 5,708E-03 ! mast cell activation GO:0045576 14 8 1,000 5,888E-04 5,686E-03 ! response to tumor cell GO:0002347 16 8 1,000 5,888E-04 5,663E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 5,888E-04 5,641E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 5,888E-04 5,619E-03 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 6,185E-04 5,88E-03 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of DNA binding GO:0043392 67 36 2,000 6,267E-04 5,934E-03 ! T cell activation GO:0042110 189 84 3,000 6,471E-04 6,104E-03 ! response to nutrient GO:0007584 135 84 3,000 6,471E-04 6,081E-03 ! hemostasis GO:0007599 165 85 3,000 6,767E-04 6,334E-03 ! negative regulation of transport GO:0051051 164 85 3,000 6,767E-04 6,309E-03 ! cell junction organization GO:0034330 96 37 2,000 6,796E-04 6,313E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 6,796E-04 6,289E-03 ! negative regulation of cell activation GO:0050866 69 37 2,000 6,796E-04 6,266E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 7,354E-04 6,754E-03 ! DNA integrity checkpoint GO:0031570 82 38 2,000 7,354E-04 6,729E-03 ! pigment metabolic process GO:0042440 87 38 2,000 7,354E-04 6,704E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 7,548E-04 6,855E-03 ! neutral lipid catabolic process GO:0046461 14 9 1,000 7,548E-04 6,829E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 7,548E-04 6,804E-03 ! T cell selection GO:0045058 27 9 1,000 7,548E-04 6,779E-03 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 7,548E-04 6,754E-03 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 7,548E-04 6,73E-03 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 7,548E-04 6,705E-03 ! negative regulation of binding GO:0051100 71 39 2,000 7,94E-04 7,028E-03 ! carbohydrate homeostasis GO:0033500 59 39 2,000 7,94E-04 7,002E-03 GO:0042593|glucose homeostasis, ! erythrocyte homeostasis GO:0034101 75 39 2,000 7,94E-04 6,977E-03 ! regulation of DNA binding GO:0051101 167 89 3,000 8,043E-04 7,043E-03 ! positive regulation of protein modification process GO:0031401 156 90 3,000 8,387E-04 7,318E-03 ! gland development GO:0048732 220 91 3,000 8,741E-04 7,6E-03 ! regulation of cell adhesion GO:0030155 241 92 3,000 9,106E-04 7,889E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 9,198E-04 7,941E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 9,406E-04 8,091E-03 ! lung alveolus development GO:0048286 26 10 1,000 9,406E-04 8,063E-03 ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 9,406E-04 8,034E-03 ! glucan biosynthetic process GO:0009250 14 10 1,000 9,406E-04 8,006E-03 GO:0005978|glycogen biosynthetic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 9,406E-04 7,979E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 9,406E-04 7,951E-03 ! positive regulation of phagocytosis GO:0050766 14 10 1,000 9,406E-04 7,924E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 9,406E-04 7,896E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 9,406E-04 7,869E-03 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 1,000 9,406E-04 7,842E-03 ! B cell proliferation GO:0042100 19 10 1,000 9,406E-04 7,816E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 9,406E-04 7,789E-03 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 9,406E-04 7,763E-03 ! synaptic vesicle endocytosis GO:0048488 23 10 1,000 9,406E-04 7,737E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 9,406E-04 7,711E-03 GO:0043470|regulation of carbohydrate catabolic process, ! negative regulation of immune effector process GO:0002698 23 10 1,000 9,406E-04 7,685E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 9,406E-04 7,659E-03 ! negative regulation of multicellular organismal process GO:0051241 174 95 3,000 1,026E-03 8,331E-03 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 1,058E-03 8,556E-03 ! sex differentiation GO:0007548 171 96 3,000 1,067E-03 8,604E-03 ! response to protein stimulus GO:0051789 158 96 3,000 1,067E-03 8,576E-03 ! response to reactive oxygen species GO:0000302 75 44 2,000 1,131E-03 9,061E-03 ! cortical actin cytoskeleton organization GO:0030866 29 11 1,000 1,146E-03 9,15E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,146E-03 9,12E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 1,146E-03 9,091E-03 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,146E-03 9,061E-03 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,146E-03 9,032E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,146E-03 9,003E-03 ! regulation of intracellular pH GO:0051453 21 11 1,000 1,146E-03 8,974E-03 ! behavioral fear response GO:0001662 27 11 1,000 1,146E-03 8,945E-03 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 1,146E-03 8,917E-03 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,146E-03 8,889E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,146E-03 8,86E-03 ! nitric oxide mediated signal transduction GO:0007263 26 11 1,000 1,146E-03 8,832E-03 ! oocyte development GO:0048599 20 11 1,000 1,146E-03 8,805E-03 ! sequestering of metal ion GO:0051238 15 11 1,000 1,146E-03 8,777E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 1,146E-03 8,75E-03 ! B cell differentiation GO:0030183 124 45 2,000 1,208E-03 9,193E-03 ! developmental growth GO:0048589 88 45 2,000 1,208E-03 9,164E-03 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 1,288E-03 9,74E-03 ! leukocyte migration GO:0050900 75 46 2,000 1,288E-03 9,71E-03 ! negative regulation of cell migration GO:0030336 122 46 2,000 1,288E-03 9,68E-03 ! pigmentation GO:0043473 103 46 2,000 1,288E-03 9,651E-03 ! cell growth GO:0016049 90 46 2,000 1,288E-03 9,621E-03 ! cortical cytoskeleton organization GO:0030865 30 12 1,000 1,371E-03 0,01021231 ! virus-host interaction GO:0019048 30 12 1,000 1,371E-03 0,01018127 ! entry into host cell GO:0030260 34 12 1,000 1,371E-03 0,01015042 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of phagocytosis GO:0050764 17 12 1,000 1,371E-03 0,01011976 ! histone acetylation GO:0016573 27 12 1,000 1,371E-03 0,01008927 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,371E-03 0,01005898 ! oocyte differentiation GO:0009994 21 12 1,000 1,371E-03 0,01002886 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 1,371E-03 9,999E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 1,371E-03 9,969E-03 ! positive regulation of defense response GO:0031349 88 48 2,000 1,457E-03 0,01056516 ! mitochondrial transport GO:0006839 94 48 2,000 1,457E-03 0,0105339 ! cellular component disassembly GO:0022411 89 48 2,000 1,457E-03 0,01050283 ! male sex differentiation GO:0046661 93 48 2,000 1,457E-03 0,01047194 ! regulation of inflammatory response GO:0050727 84 48 2,000 1,457E-03 0,01044123 ! response to calcium ion GO:0051592 94 49 2,000 1,547E-03 0,0110521 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 1,547E-03 0,01101988 ! protein homooligomerization GO:0051260 84 49 2,000 1,547E-03 0,01098785 ! regulation of chemokine production GO:0032642 18 13 1,000 1,615E-03 0,01143944 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 1,615E-03 0,01140637 ! response to X-ray GO:0010165 28 13 1,000 1,615E-03 0,0113735 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,615E-03 0,01134082 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 1,615E-03 0,01130832 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 1,615E-03 0,01127602 ! protein homotetramerization GO:0051289 24 13 1,000 1,615E-03 0,01124389 ! regulation of cytokine production during immune response GO:0002718 25 13 1,000 1,615E-03 0,01121195 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,615E-03 0,01118019 ! gland morphogenesis GO:0022612 31 13 1,000 1,615E-03 0,0111486 ! spleen development GO:0048536 24 13 1,000 1,615E-03 0,0111172 ! regulation of mRNA stability GO:0043488 32 13 1,000 1,615E-03 0,01108597 ! digestive tract morphogenesis GO:0048546 31 13 1,000 1,615E-03 0,01105492 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 1,64E-03 0,01119405 ! activation of caspase activity GO:0006919 95 50 2,000 1,64E-03 0,01116287 ! regulation of cell projection organization GO:0031344 135 51 2,000 1,737E-03 0,01178757 ! negative regulation of immune system process GO:0002683 101 51 2,000 1,737E-03 0,01175492 ! response to estrogen stimulus GO:0043627 98 52 2,000 1,837E-03 0,01239805 ! hair follicle morphogenesis GO:0031069 27 14 1,000 1,879E-03 0,0126456 ! fear response GO:0042596 34 14 1,000 1,879E-03 0,01261086 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 1,879E-03 0,01257631 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 37 14 1,000 1,879E-03 0,01254194 ! regulation of cellular pH GO:0030641 27 14 1,000 1,879E-03 0,01250777 ! regulation of RNA stability GO:0043487 33 14 1,000 1,879E-03 0,01247378 ! vesicle organization GO:0016050 127 53 2,000 1,941E-03 0,01284901 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 1,941E-03 0,01281428 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 2,000 1,941E-03 0,01277974 ! cartilage development GO:0051216 99 53 2,000 1,941E-03 0,01274539 ! regulation of angiogenesis GO:0045765 125 54 2,000 2,048E-03 0,01341341 ! regulation of translational initiation GO:0006446 87 54 2,000 2,048E-03 0,01337755 ! regulation of muscle contraction GO:0006937 94 54 2,000 2,048E-03 0,01334187 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 2,159E-03 0,01402647 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,161E-03 0,01400646 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,161E-03 0,01396941 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 2,161E-03 0,01393255 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 2,161E-03 0,01389589 ! regulation of exocytosis GO:0017157 26 15 1,000 2,161E-03 0,01385941 ! G1/S transition checkpoint GO:0031575 37 15 1,000 2,161E-03 0,01382313 ! regulation of vasodilation GO:0042312 27 15 1,000 2,161E-03 0,01378704 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 2,161E-03 0,01375114 ! regulation of bone remodeling GO:0046850 143 57 2,000 2,391E-03 0,01517496 ! positive regulation of caspase activity GO:0043280 108 57 2,000 2,391E-03 0,01513564 GO:0010952|positive regulation of peptidase activity, ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,463E-03 0,01554631 ! regulation of transmembrane transporter activity GO:0022898 27 16 1,000 2,463E-03 0,01550624 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 2,463E-03 0,01546638 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 2,463E-03 0,01542672 ! regulation of tissue remodeling GO:0034103 146 58 2,000 2,513E-03 0,01570386 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 2,000 2,513E-03 0,0156638 ! regulation of endocytosis GO:0030100 104 60 2,000 2,769E-03 0,01721043 ! kidney development GO:0001822 133 60 2,000 2,769E-03 0,01716675 ! metencephalon development GO:0022037 32 17 1,000 2,783E-03 0,0172098 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 2,783E-03 0,01716634 ! regulation of survival gene product expression GO:0045884 38 17 1,000 2,783E-03 0,0171231 ! regulation of protein binding GO:0043393 33 17 1,000 2,783E-03 0,01708007 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 2,783E-03 0,01703727 ! regulation of heart contraction GO:0008016 123 61 2,000 2,902E-03 0,0177238 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 2,902E-03 0,0176796 ! viral reproductive process GO:0022415 132 62 2,000 3,039E-03 0,01846977 ! regulation of homeostatic process GO:0032844 148 62 2,000 3,039E-03 0,01842394 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 3,121E-03 0,01887215 ! regulation of viral genome replication GO:0045069 30 18 1,000 3,121E-03 0,01882555 ! positive regulation of proteolysis GO:0045862 36 18 1,000 3,121E-03 0,01877918 ! epidermis morphogenesis GO:0048730 43 18 1,000 3,121E-03 0,01873304 ! response to retinoic acid GO:0032526 31 18 1,000 3,121E-03 0,01868713 ! long-chain fatty acid transport GO:0015909 32 18 1,000 3,121E-03 0,01864144 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 3,121E-03 0,01859597 ! defense response to virus GO:0051607 43 18 1,000 3,121E-03 0,01855073 ! regulation of protein complex assembly GO:0043254 132 63 2,000 3,18E-03 0,01885867 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 3,477E-03 0,02057005 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 1,000 3,477E-03 0,02052036 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 3,477E-03 0,02047092 ! pigmentation during development GO:0048066 42 19 1,000 3,477E-03 0,02042171 ! response to vitamin A GO:0033189 32 19 1,000 3,477E-03 0,02037273 ! heme metabolic process GO:0042168 40 19 1,000 3,477E-03 0,02032399 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 3,477E-03 0,02027549 ! protein export from nucleus GO:0006611 40 19 1,000 3,477E-03 0,02022721 ! cellular pigmentation GO:0033059 37 19 1,000 3,477E-03 0,02017917 ! gonad development GO:0008406 115 66 2,000 3,628E-03 0,02100232 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 3,852E-03 0,02224748 ! protein amino acid acetylation GO:0006473 41 20 1,000 3,852E-03 0,02219501 ! response to vitamin GO:0033273 36 20 1,000 3,852E-03 0,02214279 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 3,852E-03 0,02209081 GO:0010675|regulation of cellular carbohydrate metabolic process, ! cellular response to unfolded protein GO:0034620 35 20 1,000 3,852E-03 0,02203908 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 1,000 3,852E-03 0,02198758 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 3,852E-03 0,02193633 ! negative regulation of T cell activation GO:0050868 41 20 1,000 3,852E-03 0,02188531 ! viral reproduction GO:0016032 142 68 2,000 3,947E-03 0,02236962 ! lung development GO:0030324 165 69 2,000 4,112E-03 0,02325362 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 2,000 4,112E-03 0,02319992 ! developmental maturation GO:0021700 128 69 2,000 4,112E-03 0,02314646 ! lipid phosphorylation GO:0046834 43 21 1,000 4,245E-03 0,02383837 ! ovarian follicle development GO:0001541 39 21 1,000 4,245E-03 0,0237837 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 4,245E-03 0,02372927 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 4,245E-03 0,02367509 ! respiratory tube development GO:0030323 171 72 2,000 4,633E-03 0,02578505 ! actin filament organization GO:0007015 167 72 2,000 4,633E-03 0,02572645 ! B cell activation GO:0042113 179 72 2,000 4,633E-03 0,02566811 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 4,655E-03 0,02572857 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 4,655E-03 0,02567049 ! apoptotic nuclear changes GO:0030262 34 22 1,000 4,655E-03 0,02561267 ! ureteric bud development GO:0001657 50 22 1,000 4,655E-03 0,02555512 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 4,655E-03 0,02549782 ! renal system process GO:0003014 42 22 1,000 4,655E-03 0,02544078 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 4,655E-03 0,02538399 ! positive regulation of B cell activation GO:0050871 42 22 1,000 4,655E-03 0,02532745 ! response to cytokine stimulus GO:0034097 69 22 1,000 4,655E-03 0,02527117 ! gut development GO:0048565 44 22 1,000 4,655E-03 0,02521514 ! protein stabilization GO:0050821 41 22 1,000 4,655E-03 0,02515935 ! regulation of caspase activity GO:0043281 136 74 2,000 5,002E-03 0,02697753 ! respiratory system development GO:0060541 175 74 2,000 5,002E-03 0,02691811 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 5,083E-03 0,02729071 ! regeneration GO:0031099 42 23 1,000 5,083E-03 0,02723087 ! response to ethanol GO:0045471 47 23 1,000 5,083E-03 0,02717128 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 5,083E-03 0,02711195 ! fatty acid transport GO:0015908 47 23 1,000 5,083E-03 0,02705289 ! negative regulation of cytokine production GO:0001818 41 23 1,000 5,083E-03 0,02699408 ! learning or memory GO:0007611 161 76 2,000 5,388E-03 0,02855551 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 5,528E-03 0,02923164 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 5,528E-03 0,02916851 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 5,528E-03 0,02910565 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 5,528E-03 0,02904305 ! regulation of viral reproduction GO:0050792 41 24 1,000 5,528E-03 0,02898073 ! oogenesis GO:0048477 44 24 1,000 5,528E-03 0,02891867 ! synaptic vesicle transport GO:0048489 52 24 1,000 5,528E-03 0,02885688 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 5,528E-03 0,02879535 ! porphyrin metabolic process GO:0006778 50 24 1,000 5,528E-03 0,02873408 GO:0033013|tetrapyrrole metabolic process, ! regulation of endopeptidase activity GO:0052548 141 77 2,000 5,588E-03 0,02898444 ! regulation of catabolic process GO:0009894 173 77 2,000 5,588E-03 0,02892304 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 5,991E-03 0,03094048 ! regulation of transmembrane transport GO:0034762 39 25 1,000 5,991E-03 0,03087521 ! negative regulation of DNA replication GO:0008156 45 25 1,000 5,991E-03 0,03081021 ! lymphocyte proliferation GO:0046651 55 25 1,000 5,991E-03 0,03074548 ! liver development GO:0001889 55 25 1,000 5,991E-03 0,03068102 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 6E-03 0,03066746 ! development of primary sexual characteristics GO:0045137 143 80 2,000 6,213E-03 0,03168884 ! negative regulation of organelle organization GO:0010639 181 80 2,000 6,213E-03 0,03162283 ! initiation of viral infection GO:0019059 60 26 1,000 6,47E-03 0,03286144 ! macromolecular complex disassembly GO:0032984 54 26 1,000 6,47E-03 0,03279326 ! multicellular organismal response to stress GO:0033555 61 26 1,000 6,47E-03 0,03272537 ! negative regulation of cell development GO:0010721 83 26 1,000 6,47E-03 0,03265775 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 6,47E-03 0,03259042 GO:0045840|positive regulation of mitosis, ! regulation of peptidase activity GO:0052547 150 82 2,000 6,652E-03 0,03343935 ! protein import into nucleus GO:0006606 174 82 2,000 6,652E-03 0,03337068 ! response to drug GO:0042493 149 83 2,000 6,879E-03 0,03443502 ! nuclear import GO:0051170 177 83 2,000 6,879E-03 0,0343646 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 1,000 6,966E-03 0,03473291 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 6,966E-03 0,03466217 ! response to toxin GO:0009636 49 27 1,000 6,966E-03 0,03459172 ! cellular response to oxidative stress GO:0034599 43 27 1,000 6,966E-03 0,03452155 ! regulation of chromosome organization GO:0033044 49 27 1,000 6,966E-03 0,03445167 ! leukocyte proliferation GO:0070661 59 27 1,000 6,966E-03 0,03438207 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 6,966E-03 0,03431275 ! regulation of neuron differentiation GO:0045664 187 85 2,000 7,345E-03 0,03610273 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 7,48E-03 0,0366923 ! protein amino acid acylation GO:0043543 59 28 1,000 7,48E-03 0,03661877 ! fat cell differentiation GO:0045444 57 28 1,000 7,48E-03 0,03654553 ! base-excision repair GO:0006284 41 28 1,000 7,48E-03 0,03647258 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 8,009E-03 0,03897782 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 8,009E-03 0,03890033 ! somitogenesis GO:0001756 52 29 1,000 8,009E-03 0,03882315 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 8,009E-03 0,03874627 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 8,009E-03 0,0386697 ! amine biosynthetic process GO:0009309 146 88 2,000 8,078E-03 0,03892516 ! protein localization in nucleus GO:0034504 192 89 2,000 8,332E-03 0,04006878 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 8,555E-03 0,04106294 ! tissue homeostasis GO:0001894 50 30 1,000 8,555E-03 0,04098242 GO:0048871|multicellular organismal homeostasis, ! response to unfolded protein GO:0006986 139 90 2,000 8,59E-03 0,04106884 ! ovulation cycle process GO:0022602 55 31 1,000 9,118E-03 0,04350562 ! iron ion homeostasis GO:0055072 60 31 1,000 9,118E-03 0,04342081 ! erythrocyte differentiation GO:0030218 62 31 1,000 9,118E-03 0,04333634 ! cofactor catabolic process GO:0051187 54 31 1,000 9,118E-03 0,04325219 ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 9,394E-03 0,04447373 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 1,000 9,696E-03 0,04581817 ! spindle organization GO:0007051 50 32 1,000 9,696E-03 0,04572972 ! ovulation cycle GO:0042698 57 32 1,000 9,696E-03 0,04564161 ! hindbrain development GO:0030902 65 32 1,000 9,696E-03 0,04555384 ! myeloid leukocyte activation GO:0002274 53 32 1,000 9,696E-03 0,0454664 ! regulation of defense response GO:0031347 171 95 2,000 9,953E-03 0,04657883 ! regulation of pH GO:0006885 56 33 1,000 0,01029063 0,04806884 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,01029063 0,04797711 ! triglyceride metabolic process GO:0006641 46 33 1,000 0,01029063 0,04788572 ! biogenic amine metabolic process GO:0006576 162 97 2,000 0,01053059 0,04890918 ! post-embryonic development GO:0009791 76 34 1,000 0,01090074 0,05053229 ! cholesterol transport GO:0030301 62 34 1,000 0,01090074 0,05043658 ! regulation of ARF GTPase activity GO:0032312 73 34 1,000 0,01090074 0,05034124 ! negative regulation of secretion GO:0051048 68 35 1,000 0,01152646 0,05313046 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01152646 0,0530304 ! regulation of synaptic plasticity GO:0048167 78 35 1,000 0,01152646 0,05293072 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01152646 0,05283141 ! sterol transport GO:0015918 63 35 1,000 0,01152646 0,05273248 ! regulation of muscle development GO:0048634 82 36 1,000 0,01216762 0,0555617 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01216762 0,05545804 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 0,01216762 0,05535476 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01216762 0,05525187 ! regulation of proteolysis GO:0030162 77 36 1,000 0,01216762 0,05514936 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01216762 0,05504724 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01282408 0,05790985 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01282408 0,05780301 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01282408 0,05769655 ! tissue remodeling GO:0048771 78 37 1,000 0,01282408 0,05759049 ! female gonad development GO:0008585 71 37 1,000 0,01282408 0,05748482 ! meiosis I GO:0007127 74 38 1,000 0,01349567 0,06038449 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,01349567 0,0602741 GO:0006639|acylglycerol metabolic process, ! glycogen metabolic process GO:0005977 63 38 1,000 0,01349567 0,06016411 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01418225 0,06310973 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 0,01418225 0,06299499 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 82 40 1,000 0,01488366 0,06599054 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,01488366 0,065871 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 1,000 0,01488366 0,06575188 ! glycerol ether metabolic process GO:0006662 57 40 1,000 0,01488366 0,0656332 ! mesenchymal cell development GO:0014031 94 41 1,000 0,01559976 0,06866704 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,01559976 0,06854354 ! organic ether metabolic process GO:0018904 59 42 1,000 0,01633038 0,071625 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,01633038 0,07149664 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,01633038 0,07136874 ! cytokinesis GO:0000910 84 42 1,000 0,01633038 0,07124129 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01707539 0,07435861 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,01707539 0,0742263 ! glucose transport GO:0015758 66 43 1,000 0,01707539 0,07409446 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,01707539 0,07396309 ! monocarboxylic acid transport GO:0015718 93 43 1,000 0,01707539 0,07383218 ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,01707539 0,07370174 ! segmentation GO:0035282 78 43 1,000 0,01707539 0,07357175 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,01707539 0,07344222 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,01783464 0,07657297 ! hexose transport GO:0008645 68 44 1,000 0,01783464 0,07643863 GO:0015749|monosaccharide transport, ! phagocytosis GO:0006909 105 44 1,000 0,01783464 0,07630476 ! double-strand break repair GO:0006302 85 44 1,000 0,01783464 0,07617136 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,01860797 0,07933557 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01860797 0,07919735 ! female gamete generation GO:0007292 71 45 1,000 0,01860797 0,07905962 ! polysaccharide biosynthetic process GO:0000271 79 46 1,000 0,01939525 0,08226146 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 1,000 0,01939525 0,0821189 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,02101107 0,0888063 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,02101107 0,08865292 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,02183932 0,09198871 ! JNK cascade GO:0007254 106 49 1,000 0,02183932 0,09183038 ! endocrine system development GO:0035270 109 50 1,000 0,02268094 0,09520539 ! regulation of ARF protein signal transduction GO:0032012 115 50 1,000 0,02268094 0,09504208 ! regulation of ossification GO:0030278 123 50 1,000 0,02268094 0,09487934 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02299745 0,09603894 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02299745 0,09587505 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02299745 0,09571172 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02299745 0,09554895 ! neuron fate determination GO:0048664 7 5 0,000 0,02299745 0,09538673 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02299745 0,09522505 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02299745 0,09506393 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02299745 0,09490335 ! polyol transport GO:0015791 12 5 0,000 0,02299745 0,09474331 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02299745 0,09458381 ! response to superoxide GO:0000303 10 5 0,000 0,02299745 0,09442484 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02299745 0,09426641 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02299745 0,09410851 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02299745 0,09395114 ! female meiosis GO:0007143 10 5 0,000 0,02299745 0,09379429 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02299745 0,09363797 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02299745 0,09348217 ! hypothalamus development GO:0021854 9 5 0,000 0,02299745 0,09332688 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02299745 0,09317211 ! cobalt ion transport GO:0006824 11 5 0,000 0,02299745 0,09301785 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02299745 0,0928641 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02299745 0,09271086 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02299745 0,09255812 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02299745 0,09240589 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02299745 0,09225416 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02299745 0,09210292 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02299745 0,09195218 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02299745 0,09180193 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02299745 0,09165217 ! transposition GO:0032196 9 5 0,000 0,02299745 0,0915029 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02299745 0,09135412 ! negative chemotaxis GO:0050919 16 5 0,000 0,02299745 0,09120581 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02299745 0,09105799 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02299745 0,09091065 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02299745 0,09076378 ! behavioral response to pain GO:0048266 10 5 0,000 0,02299745 0,09061739 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02299745 0,09047147 ! Notch receptor processing GO:0007220 11 5 0,000 0,02299745 0,09032602 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02299745 0,09018103 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02299745 0,09003651 ! micturition GO:0060073 9 5 0,000 0,02299745 0,08989245 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02299745 0,08974885 ! copulation GO:0007620 9 5 0,000 0,02299745 0,08960571 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02299745 0,08946303 ! bioluminescence GO:0008218 9 5 0,000 0,02299745 0,0893208 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02299745 0,08917902 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02299745 0,08903769 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02299745 0,08889681 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02299745 0,08875637 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02299745 0,08861637 ! grooming behavior GO:0007625 6 5 0,000 0,02299745 0,08847682 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02299745 0,08833771 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02299745 0,08819903 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02299745 0,08806079 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02299745 0,08792298 ! response to protozoan GO:0001562 13 5 0,000 0,02299745 0,0877856 ! lymph vessel development GO:0001945 10 5 0,000 0,02299745 0,08764864 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02299745 0,08751212 ! endochondral ossification GO:0001958 17 5 0,000 0,02299745 0,08737602 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02299745 0,08724034 ! single strand break repair GO:0000012 8 5 0,000 0,02299745 0,08710509 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02299745 0,08697025 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02299745 0,08683583 ! cytokine secretion GO:0050663 15 5 0,000 0,02299745 0,08670182 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02299745 0,08656823 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02299745 0,08643505 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02299745 0,08630228 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02299745 0,08616991 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02299745 0,08603795 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02299745 0,08590639 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02299745 0,08577524 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02299745 0,08564448 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02299745 0,08551413 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02299745 0,08538417 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02299745 0,0852546 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02299745 0,08512543 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02299745 0,08499664 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02299745 0,08486825 ! valine metabolic process GO:0006573 12 5 0,000 0,02299745 0,08474024 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02299745 0,08461262 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02299745 0,08448539 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02299745 0,08435853 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02299745 0,08423206 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02299745 0,08410596 ! polyol catabolic process GO:0046174 9 5 0,000 0,02299745 0,08398024 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02299745 0,0838549 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02299745 0,08372993 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02299745 0,08360533 ! muscle cell migration GO:0014812 8 5 0,000 0,02299745 0,0834811 ! mitochondrial fission GO:0000266 8 5 0,000 0,02299745 0,08335724 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02299745 0,08323375 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02299745 0,08311062 ! mRNA transcription GO:0009299 10 5 0,000 0,02299745 0,08298786 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02299745 0,08286546 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02299745 0,08274342 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02299745 0,08262174 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02299745 0,08250041 ! monocyte activation GO:0042117 10 5 0,000 0,02299745 0,08237944 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02299745 0,08225883 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02299745 0,08213857 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02299745 0,08201866 ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02299745 0,0818991 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02299745 0,08177989 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02299745 0,08166102 ! forebrain neuron development GO:0021884 13 5 0,000 0,02299745 0,0815425 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02299745 0,08142432 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02299745 0,08130649 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02299745 0,08118899 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02299745 0,08107183 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02299745 0,08095502 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02299745 0,08083853 ! lipid glycosylation GO:0030259 7 5 0,000 0,02299745 0,08072239 ! nucleobase transport GO:0015851 6 5 0,000 0,02299745 0,08060657 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02299745 0,08049109 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02299745 0,08037594 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02299745 0,08026112 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02299745 0,08014662 ! basic amino acid transport GO:0015802 12 5 0,000 0,02299745 0,08003245 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02299745 0,07991861 ! actin nucleation GO:0045010 11 5 0,000 0,02299745 0,07980509 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02299745 0,07969189 ! depurination GO:0045007 5 5 0,000 0,02299745 0,07957901 ! depyrimidination GO:0045008 10 5 0,000 0,02299745 0,07946645 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02299745 0,07935421 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02299745 0,07924229 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02299745 0,07913068 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02299745 0,07901938 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02299745 0,0789084 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02299745 0,07879773 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02299745 0,07868737 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02299745 0,07857732 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02299745 0,07846757 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02299745 0,07835813 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02299745 0,078249 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02299745 0,07814017 ! response to arsenic GO:0046685 11 5 0,000 0,02299745 0,07803164 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02299745 0,07792341 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02299745 0,07781549 GO:0002448|mast cell mediated immunity, ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02299745 0,07770786 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02299745 0,07760053 ! response to mercury ion GO:0046689 8 5 0,000 0,02299745 0,07749349 ! response to cadmium ion GO:0046686 7 5 0,000 0,02299745 0,07738675 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02299745 0,0772803 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02299745 0,07717415 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02299745 0,07706829 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02299745 0,07696271 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02299745 0,07685743 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02299745 0,07675243 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02299745 0,07664772 ! decidualization GO:0046697 11 5 0,000 0,02299745 0,0765433 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02299745 0,07643916 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02299745 0,0763353 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02299745 0,07623173 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02299745 0,07612843 ! embryonic cleavage GO:0040016 6 5 0,000 0,02299745 0,07602541 ! peroxisome fission GO:0016559 5 5 0,000 0,02299745 0,07592268 ! histone demethylation GO:0016577 13 5 0,000 0,02299745 0,07582022 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02299745 0,07571803 ! mitotic recombination GO:0006312 9 5 0,000 0,02299745 0,07561613 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02299745 0,07551449 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02299745 0,07541313 ! metaphase plate congression GO:0051310 7 5 0,000 0,02299745 0,07531204 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02299745 0,07521122 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02299745 0,07511067 ! enteric nervous system development GO:0048484 8 5 0,000 0,02299745 0,07501039 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02299745 0,07491038 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02299745 0,07481063 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02299745 0,07471115 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02299745 0,07461193 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02299745 0,07451297 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02299745 0,07441428 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02299745 0,07431585 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02299745 0,07421768 ! metaphase GO:0051323 11 5 0,000 0,02299745 0,07411976 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02299745 0,07402211 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02299745 0,07392471 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02299745 0,07382757 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02299745 0,07373068 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02299745 0,07363405 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02299745 0,07353767 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02299745 0,07344154 ! response to redox state GO:0051775 6 5 0,000 0,02299745 0,07334567 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02299745 0,07325004 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02299745 0,07315466 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02299745 0,07305953 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02299745 0,07296465 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02299745 0,07287001 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02299745 0,07277562 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02299745 0,07268148 ! circadian behavior GO:0048512 15 5 0,000 0,02299745 0,07258757 ! striatum development GO:0021756 14 5 0,000 0,02299745 0,07249391 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02299745 0,07240049 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02299745 0,07230731 ! glial cell migration GO:0008347 10 5 0,000 0,02299745 0,07221437 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02299745 0,07212167 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02299745 0,07202921 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02299745 0,07193698 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02299745 0,07184499 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02299745 0,07175323 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02299745 0,07166171 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02299745 0,07157042 ! neuroprotection GO:0043526 8 5 0,000 0,02299745 0,07147937 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02299745 0,07138854 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02299745 0,07129795 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02299745 0,07120758 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02299745 0,07111744 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02299745 0,07102754 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02299745 0,07093786 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02299745 0,0708484 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,02299745 0,07075917 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02299745 0,07067017 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02299745 0,07058138 ! spindle assembly GO:0051225 6 5 0,000 0,02299745 0,07049282 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02299745 0,07040449 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02299745 0,07031637 ! protein palmitoylation GO:0018345 12 5 0,000 0,02299745 0,07022848 ! drug metabolic process GO:0017144 7 5 0,000 0,02299745 0,0701408 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02299745 0,07005334 ! organ regeneration GO:0031100 7 5 0,000 0,02299745 0,0699661 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02299745 0,06987908 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02299745 0,06979227 ! viral infectious cycle GO:0019058 104 51 1,000 0,02353579 0,0713374 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,02353579 0,071249 ! positive regulation of binding GO:0051099 88 52 1,000 0,02440374 0,07378507 ! excretion GO:0007588 87 52 1,000 0,02440374 0,07369387 ! histone modification GO:0016570 104 52 1,000 0,02440374 0,07360289 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,02440374 0,07351213 ! covalent chromatin modification GO:0016569 115 54 1,000 0,02617836 0,07876075 ! regulation of cell shape GO:0008360 142 54 1,000 0,02617836 0,07866388 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,02617836 0,07856724 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02753347 0,08253284 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02753347 0,0824317 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02753347 0,0823308 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02753347 0,08223015 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02753347 0,08212975 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02753347 0,08202959 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02753347 0,08192968 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02753347 0,08183001 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02753347 0,08173058 ! response to oxygen radical GO:0000305 11 6 0,000 0,02753347 0,08163139 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02753347 0,08153244 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02753347 0,08143373 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02753347 0,08133527 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02753347 0,08123703 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02753347 0,08113904 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02753347 0,08104128 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02753347 0,08094376 ! forebrain regionalization GO:0021871 9 6 0,000 0,02753347 0,08084647 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02753347 0,08074942 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02753347 0,0806526 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02753347 0,08055601 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02753347 0,08045965 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02753347 0,08036352 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02753347 0,08026762 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02753347 0,08017195 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02753347 0,08007651 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02753347 0,07998129 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02753347 0,0798863 ! malate metabolic process GO:0006108 13 6 0,000 0,02753347 0,07979154 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02753347 0,079697 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02753347 0,07960268 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02753347 0,07950859 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02753347 0,07941472 ! protein refolding GO:0042026 15 6 0,000 0,02753347 0,07932107 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02753347 0,07922764 ! opsonization GO:0008228 8 6 0,000 0,02753347 0,07913443 ! mating behavior GO:0007617 7 6 0,000 0,02753347 0,07904144 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02753347 0,07894867 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02753347 0,07885611 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02753347 0,07876378 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02753347 0,07867165 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02753347 0,07857975 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02753347 0,07848806 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02753347 0,07839658 ! toxin metabolic process GO:0009404 11 6 0,000 0,02753347 0,07830531 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02753347 0,07821426 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02753347 0,07812342 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02753347 0,07803279 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02753347 0,07794237 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02753347 0,07785216 ! thymic T cell selection GO:0045061 16 6 0,000 0,02753347 0,07776216 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02753347 0,07767236 ! protein lipoylation GO:0009249 10 6 0,000 0,02753347 0,07758277 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02753347 0,07749339 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02753347 0,07740422 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02753347 0,07731525 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02753347 0,07722648 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02753347 0,07713792 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02753347 0,07704956 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02753347 0,0769614 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02753347 0,07687345 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02753347 0,07678569 ! hyperosmotic response GO:0006972 10 6 0,000 0,02753347 0,07669814 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02753347 0,07661078 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02753347 0,07652362 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02753347 0,07643666 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02753347 0,0763499 ! urea metabolic process GO:0019627 7 6 0,000 0,02753347 0,07626334 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02753347 0,07617697 ! neutrophil activation GO:0042119 7 6 0,000 0,02753347 0,0760908 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02753347 0,07600482 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02753347 0,07591903 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02753347 0,07583344 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02753347 0,07574805 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02753347 0,07566284 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02753347 0,07557783 ! neuron apoptosis GO:0051402 15 6 0,000 0,02753347 0,075493 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02753347 0,07540837 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02753347 0,07532392 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02753347 0,07523967 ! carnitine transport GO:0015879 10 6 0,000 0,02753347 0,0751556 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02753347 0,07507172 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02753347 0,07498803 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02753347 0,07490453 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02753347 0,07482121 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02753347 0,07473807 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02753347 0,07465512 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02753347 0,07457236 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02753347 0,07448977 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02753347 0,07440737 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02753347 0,07432515 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02753347 0,07424312 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,02753347 0,07416126 ! astrocyte development GO:0014002 16 6 0,000 0,02753347 0,07407959 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02753347 0,07399809 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02753347 0,07391677 ! interaction with symbiont GO:0051702 14 6 0,000 0,02753347 0,07383564 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02753347 0,07375468 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02753347 0,07367389 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02753347 0,07359329 ! response to copper ion GO:0046688 10 6 0,000 0,02753347 0,07351286 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02753347 0,0734326 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02753347 0,07335252 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02753347 0,07327262 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02753347 0,07319289 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02753347 0,07311333 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02753347 0,07303395 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02753347 0,07295473 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02753347 0,07287569 ! Schwann cell development GO:0014044 15 6 0,000 0,02753347 0,07279682 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02753347 0,07271812 ! response to pheromone GO:0019236 6 6 0,000 0,02753347 0,07263959 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02753347 0,07256123 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02753347 0,07248304 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02753347 0,07240502 ! subpallium development GO:0021544 15 6 0,000 0,02753347 0,07232717 ! neural tube patterning GO:0021532 8 6 0,000 0,02753347 0,07224948 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02753347 0,07217196 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02753347 0,0720946 ! G2 phase GO:0051319 16 6 0,000 0,02753347 0,07201741 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02753347 0,07194039 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02753347 0,07186353 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02753347 0,07178684 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02753347 0,0717103 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02753347 0,07163393 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02753347 0,07155773 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02753347 0,07148168 ! receptor internalization GO:0031623 11 6 0,000 0,02753347 0,0714058 ! plasminogen activation GO:0031639 9 6 0,000 0,02753347 0,07133008 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02753347 0,07125452 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02753347 0,07117912 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02753347 0,07110387 ! protein deubiquitination GO:0016579 16 6 0,000 0,02753347 0,07102879 ! protein destabilization GO:0031648 9 6 0,000 0,02753347 0,07095387 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02753347 0,0708791 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02753347 0,07080449 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02753347 0,07073004 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02753347 0,07065574 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02753347 0,0705816 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02753347 0,07050762 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02753347 0,07043379 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02753347 0,07036011 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02753347 0,07028659 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02753347 0,07021322 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02753347 0,07014001 ! neural plate development GO:0001840 9 6 0,000 0,02753347 0,07006694 ! catecholamine transport GO:0051937 9 6 0,000 0,02753347 0,06999403 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02753347 0,06992127 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02753347 0,06984867 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02753347 0,06977621 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02753347 0,0697039 ! maternal placenta development GO:0001893 12 6 0,000 0,02753347 0,06963174 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02753347 0,06955974 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02753347 0,06948788 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02753347 0,06941617 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02753347 0,0693446 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02753347 0,06927319 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02753347 0,06920192 GO:0055081|anion homeostasis, ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,0280037 0,07031145 ! heart morphogenesis GO:0003007 105 57 1,000 0,02893506 0,0725753 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,02893506 0,07250086 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,02987869 0,07478856 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,02987869 0,07471201 ! maintenance of location GO:0051235 124 58 1,000 0,02987869 0,07463561 ! nuclear export GO:0051168 110 59 1,000 0,03083446 0,07694442 ! lipid modification GO:0030258 112 60 1,000 0,03180225 0,07927846 ! DNA catabolic process GO:0006308 94 60 1,000 0,03180225 0,07919765 ! heterocycle catabolic process GO:0046700 100 60 1,000 0,03180225 0,079117 ! tRNA transcription GO:0009304 17 7 0,000 0,03204855 0,07964864 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03204855 0,07956769 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03204855 0,07948691 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03204855 0,0794063 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03204855 0,07932585 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03204855 0,07924556 ! sleep GO:0030431 16 7 0,000 0,03204855 0,07916543 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03204855 0,07908546 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03204855 0,07900566 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03204855 0,07892602 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03204855 0,07884654 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03204855 0,07876721 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03204855 0,07868805 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03204855 0,07860905 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03204855 0,0785302 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03204855 0,07845151 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03204855 0,07837298 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03204855 0,07829461 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03204855 0,07821639 ! glycolipid transport GO:0046836 11 7 0,000 0,03204855 0,07813833 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03204855 0,07806043 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,03204855 0,07798268 ! neuron adhesion GO:0007158 14 7 0,000 0,03204855 0,07790508 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03204855 0,07782764 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03204855 0,07775036 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03204855 0,07767322 ! pericardium development GO:0060039 16 7 0,000 0,03204855 0,07759624 ! fibril organization GO:0043206 17 7 0,000 0,03204855 0,07751942 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03204855 0,07744274 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03204855 0,07736622 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03204855 0,07728984 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03204855 0,07721362 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03204855 0,07713755 ! rhythmic behavior GO:0007622 17 7 0,000 0,03204855 0,07706162 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03204855 0,07698585 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03204855 0,07691023 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03204855 0,07683475 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03204855 0,07675942 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03204855 0,07668424 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03204855 0,07660921 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03204855 0,07653432 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03204855 0,07645958 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03204855 0,07638499 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03204855 0,07631054 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03204855 0,07623623 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03204855 0,07616207 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03204855 0,07608806 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03204855 0,07601418 ! spinal cord patterning GO:0021511 14 7 0,000 0,03204855 0,07594046 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03204855 0,07586687 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03204855 0,07579343 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03204855 0,07572013 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03204855 0,07564697 ! adrenal gland development GO:0030325 17 7 0,000 0,03204855 0,07557395 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03204855 0,07550107 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03204855 0,07542833 ! ovulation GO:0030728 10 7 0,000 0,03204855 0,07535574 ! adenohypophysis development GO:0021984 11 7 0,000 0,03204855 0,07528328 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03204855 0,07521096 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03204855 0,07513878 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03204855 0,07506674 ! microtubule nucleation GO:0007020 21 7 0,000 0,03204855 0,07499484 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03204855 0,07492307 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03204855 0,07485144 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03204855 0,07477995 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03204855 0,0747086 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03204855 0,07463738 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03204855 0,07456629 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03204855 0,07449535 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03204855 0,07442453 ! galactose metabolic process GO:0006012 13 7 0,000 0,03204855 0,07435386 ! vesicle fusion GO:0006906 20 7 0,000 0,03204855 0,07428331 ! response to dietary excess GO:0002021 8 7 0,000 0,03204855 0,0742129 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03204855 0,07414262 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03204855 0,07407248 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,03204855 0,07400247 ! nucleoside transport GO:0015858 11 7 0,000 0,03204855 0,07393259 ! nucleoside salvage GO:0043174 11 7 0,000 0,03204855 0,07386284 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03204855 0,07379322 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03204855 0,07372374 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03204855 0,07365438 ! parturition GO:0007567 16 7 0,000 0,03204855 0,07358516 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03204855 0,07351607 ! rRNA modification GO:0000154 14 7 0,000 0,03204855 0,0734471 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03204855 0,07337827 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03204855 0,07330956 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03204855 0,07324098 ! monocyte differentiation GO:0030224 16 7 0,000 0,03204855 0,07317253 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03204855 0,07310421 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03204855 0,07303602 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03204855 0,07296795 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03204855 0,07290001 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03204855 0,0728322 ! fibrinolysis GO:0042730 11 7 0,000 0,03204855 0,07276451 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03204855 0,07269694 ! eating behavior GO:0042755 8 7 0,000 0,03204855 0,07262951 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03204855 0,0725622 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03204855 0,07249501 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03204855 0,07242795 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03204855 0,07236101 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03204855 0,07229419 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03204855 0,0722275 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03204855 0,07216093 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03204855 0,07209448 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03204855 0,07202816 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03204855 0,07196196 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03204855 0,07189588 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03204855 0,07182992 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03204855 0,07176408 ! histone ubiquitination GO:0016574 9 7 0,000 0,03204855 0,07169836 ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03204855 0,07163276 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03204855 0,07156728 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03204855 0,07150193 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03204855 0,07143669 ! transcription termination GO:0006353 14 7 0,000 0,03204855 0,07137157 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03204855 0,07130657 ! anaphase GO:0051322 18 7 0,000 0,03204855 0,07124168 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03204855 0,07117692 ! axonal fasciculation GO:0007413 19 7 0,000 0,03204855 0,07111227 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03204855 0,07104774 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03204855 0,07098333 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,03204855 0,07091903 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03204855 0,07085485 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03204855 0,07079079 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03204855 0,07072684 ! antibiotic transport GO:0042891 9 7 0,000 0,03204855 0,07066301 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03204855 0,07059929 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03204855 0,07053568 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03204855 0,0704722 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03204855 0,07040882 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03204855 0,07034556 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03204855 0,07028241 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03204855 0,07021938 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03204855 0,07015646 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03204855 0,07009365 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03204855 0,07003096 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03204855 0,06996837 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03204855 0,0699059 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03204855 0,06984354 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03204855 0,06978129 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03204855 0,06971915 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03204855 0,06965713 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03204855 0,06959521 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03204855 0,0695334 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03204855 0,0694717 ! retina homeostasis GO:0001895 12 7 0,000 0,03204855 0,06941011 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03204855 0,06934864 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03204855 0,06928727 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03204855 0,069226 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03204855 0,06916485 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,03278192 0,07068511 ! camera-type eye development GO:0043010 126 61 1,000 0,03278192 0,07062278 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,0365428 0,07865555 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,0365428 0,07858631 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,0365428 0,07851719 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,0365428 0,0784482 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,0365428 0,07837932 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,0365428 0,07831057 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,0365428 0,07824194 ! male meiosis GO:0007140 9 8 0,000 0,0365428 0,07817342 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,0365428 0,07810503 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,0365428 0,07803676 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,0365428 0,0779686 ! meiotic prophase I GO:0007128 14 8 0,000 0,0365428 0,07790057 ! response to zinc ion GO:0010043 12 8 0,000 0,0365428 0,07783265 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,0365428 0,07776485 ! oligopeptide transport GO:0006857 16 8 0,000 0,0365428 0,07769717 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,0365428 0,07762961 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,0365428 0,07756216 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,0365428 0,07749484 ! signal peptide processing GO:0006465 12 8 0,000 0,0365428 0,07742762 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,0365428 0,07736053 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,0365428 0,07729355 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,0365428 0,07722669 ! succinate metabolic process GO:0006105 17 8 0,000 0,0365428 0,07715994 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,0365428 0,07709331 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,0365428 0,07702679 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,0365428 0,07696039 ! estrogen metabolic process GO:0008210 17 8 0,000 0,0365428 0,0768941 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,0365428 0,07682793 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,0365428 0,07676187 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,0365428 0,07669592 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0365428 0,07663009 ! reflex GO:0060004 17 8 0,000 0,0365428 0,07656437 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,0365428 0,07649876 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,0365428 0,07643326 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,0365428 0,07636788 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,0365428 0,07630261 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,0365428 0,07623745 ! astrocyte differentiation GO:0048708 19 8 0,000 0,0365428 0,0761724 ! histidine catabolic process GO:0006548 10 8 0,000 0,0365428 0,07610746 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,0365428 0,07604263 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,0365428 0,07597792 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,0365428 0,07591331 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,0365428 0,07584881 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,0365428 0,07578442 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,0365428 0,07572014 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,0365428 0,07565598 ! macrophage activation GO:0042116 13 8 0,000 0,0365428 0,07559191 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,0365428 0,07552796 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,0365428 0,07546412 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,0365428 0,07540038 ! purine salvage GO:0043101 12 8 0,000 0,0365428 0,07533675 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,0365428 0,07527323 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,0365428 0,07520982 ! osteoblast development GO:0002076 17 8 0,000 0,0365428 0,07514651 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,0365428 0,07508331 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,0365428 0,07502021 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,0365428 0,07495722 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,0365428 0,07489434 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,0365428 0,07483156 ! intermediate filament organization GO:0045109 12 8 0,000 0,0365428 0,07476889 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,0365428 0,07470632 ! cellular extravasation GO:0045123 13 8 0,000 0,0365428 0,07464385 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,0365428 0,0745815 ! response to antibiotic GO:0046677 11 8 0,000 0,0365428 0,07451924 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,0365428 0,07445709 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,0365428 0,07439504 ! DNA topological change GO:0006265 12 8 0,000 0,0365428 0,0743331 ! response to tropane GO:0014073 15 8 0,000 0,0365428 0,07427126 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,0365428 0,07420952 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,0365428 0,07414788 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,0365428 0,07408635 ! multicellular organismal aging GO:0010259 20 8 0,000 0,0365428 0,07402492 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,0365428 0,07396359 ! gas homeostasis GO:0033483 14 8 0,000 0,0365428 0,07390236 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,0365428 0,07384123 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,0365428 0,07378021 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,0365428 0,07371928 ! nucleosome disassembly GO:0006337 14 8 0,000 0,0365428 0,07365846 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,0365428 0,07359773 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,0365428 0,07353711 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,0365428 0,07347658 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,0365428 0,07341616 ! intracellular lipid transport GO:0032365 16 8 0,000 0,0365428 0,07335583 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,0365428 0,07329561 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,0365428 0,07323548 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,0365428 0,07317545 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,0365428 0,07311552 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,0365428 0,07305569 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,0365428 0,07299595 ! hormone catabolic process GO:0042447 17 8 0,000 0,0365428 0,07293632 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,0365428 0,07287678 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,0365428 0,07281733 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,0365428 0,07275799 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,0365428 0,07269874 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,0365428 0,07263959 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,0365428 0,07258053 ! adult feeding behavior GO:0008343 10 8 0,000 0,0365428 0,07252157 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,0365428 0,0724627 ! ATP catabolic process GO:0006200 11 8 0,000 0,0365428 0,07240393 ! blastocyst growth GO:0001832 19 8 0,000 0,0365428 0,07234526 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,0365428 0,07228668 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,0365428 0,0722282 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,0365428 0,07216981 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,0365428 0,07211151 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,0365428 0,07205331 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,0365428 0,0719952 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,0365428 0,07193719 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,0365428 0,07187927 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,0365428 0,07182144 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,0365428 0,07176371 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,0365428 0,07170606 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,0365428 0,07164852 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,0365428 0,07159106 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,0365428 0,07153369 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,0365428 0,07147642 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,0365428 0,07141924 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,0365428 0,07136215 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,0365428 0,07130515 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,0365428 0,07124824 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,03681684 0,07172532 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,03681684 0,07166817 GO:0048609|reproductive process in a multicellular organism, ! ear development GO:0043583 114 66 1,000 0,037854 0,07362844 ! regulation of cytokine biosynthetic process GO:0042035 108 66 1,000 0,037854 0,07356986 ! activation of MAPK activity GO:0000187 124 67 1,000 0,03890227 0,07554709 ! chromosome segregation GO:0007059 127 67 1,000 0,03890227 0,07548709 ! secondary metabolic process GO:0019748 125 67 1,000 0,03890227 0,07542718 ! adaptive immune response GO:0002250 126 68 1,000 0,03996154 0,07741953 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! axon extension GO:0048675 16 9 0,000 0,0410163 0,07940002 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,0410163 0,07933715 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,0410163 0,07927438 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,0410163 0,07921172 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,0410163 0,07914915 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,0410163 0,07908668 ! reproductive behavior GO:0019098 22 9 0,000 0,0410163 0,07902431 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,0410163 0,07896203 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,0410163 0,07889986 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,0410163 0,07883778 ! UTP metabolic process GO:0046051 10 9 0,000 0,0410163 0,0787758 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,0410163 0,07871392 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,0410163 0,07865214 ! artery development GO:0060840 25 9 0,000 0,0410163 0,07859045 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,0410163 0,07852886 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,0410163 0,07846736 ! equilibrioception GO:0050957 20 9 0,000 0,0410163 0,07840596 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,0410163 0,07834466 ! chemosensory behavior GO:0007635 21 9 0,000 0,0410163 0,07828345 ! microtubule bundle formation GO:0001578 22 9 0,000 0,0410163 0,07822234 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,0410163 0,07816133 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,0410163 0,07810041 ! leukocyte degranulation GO:0043299 16 9 0,000 0,0410163 0,07803958 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,0410163 0,07797885 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,0410163 0,07791821 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,0410163 0,07785767 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,0410163 0,07779722 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,0410163 0,07773687 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,0410163 0,07767661 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,0410163 0,07761644 ! protein targeting to ER GO:0045047 25 9 0,000 0,0410163 0,07755636 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,0410163 0,07749638 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,0410163 0,07743649 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,0410163 0,0773767 ! glycine catabolic process GO:0006546 15 9 0,000 0,0410163 0,07731699 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,0410163 0,07725738 ! endosome organization GO:0007032 20 9 0,000 0,0410163 0,07719786 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,0410163 0,07713843 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,0410163 0,07707909 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,0410163 0,07701985 ! mannose metabolic process GO:0006013 13 9 0,000 0,0410163 0,07696069 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,0410163 0,07690163 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,0410163 0,07684265 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,0410163 0,07678377 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,0410163 0,07672498 ! receptor clustering GO:0043113 20 9 0,000 0,0410163 0,07666627 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,0410163 0,07660766 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,0410163 0,07654914 ! retinol metabolic process GO:0042572 20 9 0,000 0,0410163 0,0764907 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,0410163 0,07643236 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,0410163 0,0763741 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,0410163 0,07631593 ! oligodendrocyte development GO:0014003 11 9 0,000 0,0410163 0,07625785 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,0410163 0,07619986 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,0410163 0,07614196 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,0410163 0,07608415 ! response to amine stimulus GO:0014075 13 9 0,000 0,0410163 0,07602642 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,0410163 0,07596878 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,0410163 0,07591123 ! erythrocyte development GO:0048821 17 9 0,000 0,0410163 0,07585376 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,0410163 0,07579638 ! renal water homeostasis GO:0003091 15 9 0,000 0,0410163 0,07573909 ! postreplication repair GO:0006301 25 9 0,000 0,0410163 0,07568189 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,0410163 0,07562477 ! icosanoid secretion GO:0032309 15 9 0,000 0,0410163 0,07556774 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,0410163 0,07551079 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,0410163 0,07545393 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,0410163 0,07539716 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,0410163 0,07534047 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,0410163 0,07528386 ! sterol catabolic process GO:0016127 14 9 0,000 0,0410163 0,07522734 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,0410163 0,07517091 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,0410163 0,07511456 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,0410163 0,07505829 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,0410163 0,07500211 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,0410163 0,07494601 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,0410163 0,07489 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,0410163 0,07483407 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,0410163 0,07477822 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,0410163 0,07472246 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,0410163 0,07466678 ! purine base metabolic process GO:0006144 25 9 0,000 0,0410163 0,07461118 ! pigment granule transport GO:0051904 17 9 0,000 0,0410163 0,07455567 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,0410163 0,07450024 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,0410163 0,07444489 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,0410163 0,07438962 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,0410163 0,07433444 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,0410163 0,07427933 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,0410163 0,07422431 ! mitochondrion localization GO:0051646 18 9 0,000 0,0410163 0,07416937 ! carbohydrate transport GO:0008643 114 72 1,000 0,04430608 0,08005899 ! humoral immune response GO:0006959 115 73 1,000 0,04541848 0,08200839 ! regulation of immune effector process GO:0002697 156 73 1,000 0,04541848 0,08194783 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,04546916 0,08197871 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04546916 0,08191825 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04546916 0,08185789 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04546916 0,08179761 ! associative learning GO:0008306 21 10 0,000 0,04546916 0,08173742 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,04546916 0,08167732 ! phosphate transport GO:0006817 24 10 0,000 0,04546916 0,08161731 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04546916 0,08155738 ! CTP metabolic process GO:0046036 11 10 0,000 0,04546916 0,08149754 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,04546916 0,0814378 ! GTP metabolic process GO:0046039 11 10 0,000 0,04546916 0,08137813 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04546916 0,08131856 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04546916 0,08125907 ! social behavior GO:0035176 29 10 0,000 0,04546916 0,08119967 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04546916 0,08114036 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04546916 0,08108113 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,04546916 0,08102199 ! androgen metabolic process GO:0008209 17 10 0,000 0,04546916 0,08096294 ! phospholipid efflux GO:0033700 19 10 0,000 0,04546916 0,08090397 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,04546916 0,08084509 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04546916 0,08078629 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04546916 0,08072758 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,04546916 0,08066896 ! pathogenesis GO:0009405 17 10 0,000 0,04546916 0,08061042 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04546916 0,08055196 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04546916 0,08049359 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04546916 0,0804353 ! endoderm development GO:0007492 18 10 0,000 0,04546916 0,0803771 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,04546916 0,08031898 ! arginine catabolic process GO:0006527 17 10 0,000 0,04546916 0,08026095 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,04546916 0,080203 ! proline metabolic process GO:0006560 13 10 0,000 0,04546916 0,08014513 ! phosphagen metabolic process GO:0006599 17 10 0,000 0,04546916 0,08008735 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,04546916 0,08002965 ! V(D)J recombination GO:0033151 34 10 0,000 0,04546916 0,07997203 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04546916 0,0799145 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04546916 0,07985705 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04546916 0,07979968 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04546916 0,07974239 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04546916 0,07968519 ! multicellular organism growth GO:0035264 19 10 0,000 0,04546916 0,07962807 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,04546916 0,07957103 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04546916 0,07951407 ! ruffle organization GO:0031529 17 10 0,000 0,04546916 0,07945719 ! epithelial cell development GO:0002064 21 10 0,000 0,04546916 0,0794004 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,04546916 0,07934368 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04546916 0,07928705 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04546916 0,07923049 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04546916 0,07917402 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,04546916 0,07911763 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04546916 0,07906132 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 22 10 0,000 0,04546916 0,07900509 ! copper ion homeostasis GO:0055070 13 10 0,000 0,04546916 0,07894894 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,04546916 0,07889286 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,04546916 0,07883687 ! segment specification GO:0007379 15 10 0,000 0,04546916 0,07878096 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04546916 0,07872513 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04546916 0,07866937 ! response to dsRNA GO:0043331 23 10 0,000 0,04546916 0,0786137 ! DNA ligation GO:0006266 18 10 0,000 0,04546916 0,0785581 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,04546916 0,07850258 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04546916 0,07844714 ! melanosome localization GO:0032400 16 10 0,000 0,04546916 0,07839178 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04546916 0,0783365 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,04546916 0,07828129 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,04546916 0,07822616 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,04546916 0,07817111 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,04546916 0,07811614 ! induction of an organ GO:0001759 17 10 0,000 0,04546916 0,07806125 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04546916 0,07800643 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04546916 0,07795169 ! protein sumoylation GO:0016925 17 10 0,000 0,04546916 0,07789702 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04546916 0,07784243 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04546916 0,07778792 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04546916 0,07773349 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04546916 0,07767913 ! salivary gland development GO:0007431 28 10 0,000 0,04546916 0,07762484 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04546916 0,07757064 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,04546916 0,07751651 ! midbrain development GO:0030901 14 10 0,000 0,04546916 0,07746245 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04546916 0,07740847 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,04546916 0,07735456 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04546916 0,07730073 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,04546916 0,07724698 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,04546916 0,0771933 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04546916 0,07713969 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04546916 0,07708616 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,04546916 0,0770327 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04546916 0,07697932 ! detection of calcium ion GO:0005513 24 10 0,000 0,04546916 0,07692601 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,04546916 0,07687277 ! blastocyst formation GO:0001825 18 10 0,000 0,04546916 0,07681961 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,04546916 0,07676652 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04546916 0,0767135 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04546916 0,07666056 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04546916 0,07660769 ! eye development GO:0001654 155 75 1,000 0,04767397 0,08026707 ! rhythmic process GO:0048511 142 75 1,000 0,04767397 0,08021179 ! regulation of blood pressure GO:0008217 134 76 1,000 0,04881682 0,08207811 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,04990146 0,08384407 ! respiratory burst GO:0045730 17 11 0,000 0,04990146 0,08378645 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,04990146 0,0837289 ! neuron fate specification GO:0048665 18 11 0,000 0,04990146 0,08367143 ! telencephalon cell migration GO:0022029 23 11 0,000 0,04990146 0,08361405 ! thyroid gland development GO:0030878 26 11 0,000 0,04990146 0,08355674 ! synapsis GO:0007129 14 11 0,000 0,04990146 0,08349951 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,04990146 0,08344235 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,04990146 0,08338528 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,04990146 0,08332828 ! response to pain GO:0048265 27 11 0,000 0,04990146 0,08327137 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,04990146 0,08321452 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,04990146 0,08315776 ! bone resorption GO:0045453 16 11 0,000 0,04990146 0,08310108 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,04990146 0,08304447 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04990146 0,08298794 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04990146 0,08293148 ! melanocyte differentiation GO:0030318 20 11 0,000 0,04990146 0,0828751 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,04990146 0,0828188 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,04990146 0,08276258 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,04990146 0,08270643 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,04990146 0,08265036 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,04990146 0,08259436 ! UV protection GO:0009650 20 11 0,000 0,04990146 0,08253844 ! adult heart development GO:0007512 16 11 0,000 0,04990146 0,0824826 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04990146 0,08242683 ! macroautophagy GO:0016236 19 11 0,000 0,04990146 0,08237113 ! temperature homeostasis GO:0001659 18 11 0,000 0,04990146 0,08231552 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,04990146 0,08225997 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,04990146 0,0822045 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,04990146 0,08214911 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,04990146 0,08209379 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,04990146 0,08203855 ! regulation of organ growth GO:0046620 14 11 0,000 0,04990146 0,08198337 ! pigment granule localization GO:0051875 20 11 0,000 0,04990146 0,08192828 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,04990146 0,08187326 ! vasoconstriction GO:0042310 20 11 0,000 0,04990146 0,08181831 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,04990146 0,08176343 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04990146 0,08170863 ! embryonic axis specification GO:0000578 19 11 0,000 0,04990146 0,0816539 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,04990146 0,08159925 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04990146 0,08154467 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,04990146 0,08149016 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,04990146 0,08143572 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,04990146 0,08138136 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,04990146 0,08132707 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,04990146 0,08127285 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,04990146 0,08121871 ! prophase GO:0051324 17 11 0,000 0,04990146 0,08116463 ! neuroblast proliferation GO:0007405 25 11 0,000 0,04990146 0,08111063 ! nucleosome positioning GO:0016584 15 11 0,000 0,04990146 0,0810567 ! regulation of isotype switching GO:0045191 24 11 0,000 0,04990146 0,08100284 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,04990146 0,08094906 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,04990146 0,08089534 ! apical protein localization GO:0045176 18 11 0,000 0,04990146 0,0808417 ! acid secretion GO:0046717 20 11 0,000 0,04990146 0,08078812 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04990146 0,08073462 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,04990146 0,08068119 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,04990146 0,08062783 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,04990146 0,08057454 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,04990146 0,08052132 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04990146 0,08046817 ! germ cell migration GO:0008354 26 11 0,000 0,04990146 0,08041509 ! embryonic gut development GO:0048566 19 11 0,000 0,04990146 0,08036208 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,04990146 0,08030914 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,04990146 0,08025627 ! activation of innate immune response GO:0002218 16 11 0,000 0,04990146 0,08020347 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,04990146 0,08015074 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,04990146 0,08009808 ! lysogeny GO:0030069 22 11 0,000 0,04990146 0,08004549 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04990146 0,07999296 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,04990146 0,07994051 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,04996959 0,07999719 ! antigen processing and presentation GO:0019882 117 78 1,000 0,05113216 0,08180475 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,05113216 0,08175122 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,05230441 0,08357075 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,05431331 0,08672381 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,05431331 0,08666716 ! mating GO:0007618 17 12 0,000 0,05431331 0,08661059 ! protein complex disassembly GO:0043241 28 12 0,000 0,05431331 0,08655409 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05431331 0,08649767 ! hippocampus development GO:0021766 29 12 0,000 0,05431331 0,08644132 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,05431331 0,08638504 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,05431331 0,08632884 ! T cell proliferation GO:0042098 32 12 0,000 0,05431331 0,08627271 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05431331 0,08621665 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,05431331 0,08616067 ! ventral spinal cord development GO:0021517 25 12 0,000 0,05431331 0,08610476 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,05431331 0,08604892 ! drug transport GO:0015893 16 12 0,000 0,05431331 0,08599315 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,05431331 0,08593745 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,05431331 0,08588183 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,05431331 0,08582628 ! polyamine metabolic process GO:0006595 18 12 0,000 0,05431331 0,0857708 ! mitotic spindle organization GO:0007052 23 12 0,000 0,05431331 0,08571539 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,05431331 0,08566006 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,05431331 0,08560479 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,05431331 0,0855496 ! lipid digestion GO:0044241 21 12 0,000 0,05431331 0,08549448 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,05431331 0,08543943 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05431331 0,08538444 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,05431331 0,08532954 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,05431331 0,0852747 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05431331 0,08521993 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,05431331 0,08516523 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,05431331 0,0851106 ! snRNA metabolic process GO:0016073 30 12 0,000 0,05431331 0,08505604 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,05431331 0,08500156 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,05431331 0,08494714 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05431331 0,08489279 ! cranial nerve development GO:0021545 23 12 0,000 0,05431331 0,08483851 ! fucose catabolic process GO:0019317 25 12 0,000 0,05431331 0,0847843 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,05431331 0,08473016 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,05431331 0,08467609 ! autonomic nervous system development GO:0048483 24 12 0,000 0,05431331 0,08462208 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,05431331 0,08456815 ! zymogen activation GO:0031638 18 12 0,000 0,05431331 0,08451429 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,05431331 0,08446049 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,05431331 0,08440676 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,05431331 0,0843531 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,05431331 0,08429951 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,05431331 0,08424599 ! defense response to fungus GO:0050832 15 12 0,000 0,05431331 0,08419253 ! developmental induction GO:0031128 22 12 0,000 0,05431331 0,08413914 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,05431331 0,08408582 ! lamellipodium assembly GO:0030032 24 12 0,000 0,05431331 0,08403257 ! response to cold GO:0009409 17 12 0,000 0,05431331 0,08397938 ! establishment of cell polarity GO:0030010 21 12 0,000 0,05431331 0,08392627 ! regulation of synapse organization GO:0050807 18 12 0,000 0,05431331 0,08387322 ! localization within membrane GO:0051668 26 12 0,000 0,05431331 0,08382023 ! meiosis GO:0007126 143 81 1,000 0,05467752 0,08432902 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,05467752 0,08427582 ! meiotic cell cycle GO:0051321 144 82 1,000 0,05587815 0,08607208 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,05708802 0,08788029 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,0587048 0,09031224 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0587048 0,0902554 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,0587048 0,09019863 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0587048 0,09014194 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,0587048 0,09008532 ! peroxisomal transport GO:0043574 28 13 0,000 0,0587048 0,09002877 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,0587048 0,08997229 ! cartilage condensation GO:0001502 22 13 0,000 0,0587048 0,08991588 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,0587048 0,08985954 ! organelle fusion GO:0048284 36 13 0,000 0,0587048 0,08980327 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,0587048 0,08974708 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,0587048 0,08969095 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,0587048 0,08963489 ! endocrine pancreas development GO:0031018 25 13 0,000 0,0587048 0,08957891 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,0587048 0,08952299 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,0587048 0,08946714 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,0587048 0,08941136 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,0587048 0,08935566 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,0587048 0,08930002 ! methionine metabolic process GO:0006555 31 13 0,000 0,0587048 0,08924445 ! plasma membrane organization GO:0007009 27 13 0,000 0,0587048 0,08918895 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,0587048 0,08913352 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,0587048 0,08907815 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,0587048 0,08902286 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,0587048 0,08896764 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,0587048 0,08891248 ! exocrine system development GO:0035272 34 13 0,000 0,0587048 0,08885739 ! asymmetric protein localization GO:0008105 24 13 0,000 0,0587048 0,08880237 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,0587048 0,08874742 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,0587048 0,08869254 ! L-glutamate transport GO:0015813 30 13 0,000 0,0587048 0,08863772 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,0587048 0,08858297 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,0587048 0,08852829 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,0587048 0,08847368 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,0587048 0,08841913 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,0587048 0,08836465 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0587048 0,08831024 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,0587048 0,08825589 ! histone methylation GO:0016571 29 13 0,000 0,0587048 0,08820162 ! chromatin silencing GO:0006342 29 13 0,000 0,0587048 0,08814741 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,0587048 0,08809326 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,0587048 0,08803918 ! regulation of epidermis development GO:0045682 19 13 0,000 0,0587048 0,08798517 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,0587048 0,08793123 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,0587048 0,08787735 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,0587048 0,08782353 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,0587048 0,08776979 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,0587048 0,0877161 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,0587048 0,08766249 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,0587048 0,08760894 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,0587048 0,08755545 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,0587048 0,08750203 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,0587048 0,08744868 ! insulin secretion GO:0030073 24 13 0,000 0,0587048 0,08739539 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,0587048 0,08734216 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,0587048 0,087289 ! acrosome reaction GO:0007340 19 13 0,000 0,0587048 0,08723591 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,0587048 0,08718287 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,0587048 0,08712991 ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,05953502 0,08830846 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,06077193 0,09008849 GO:0002696|positive regulation of leukocyte activation, ! rRNA transcription GO:0009303 28 14 0,000 0,06307602 0,09344737 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06307602 0,09339073 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,06307602 0,09333417 ! water transport GO:0006833 21 14 0,000 0,06307602 0,09327767 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06307602 0,09322124 ! non-recombinational repair GO:0000726 29 14 0,000 0,06307602 0,09316488 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,06307602 0,09310859 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06307602 0,09305236 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06307602 0,09299621 ! lipid localization GO:0010876 32 14 0,000 0,06307602 0,09294012 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,06307602 0,09288409 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06307602 0,09282814 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06307602 0,09277225 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06307602 0,09271643 ! arginine metabolic process GO:0006525 21 14 0,000 0,06307602 0,09266068 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06307602 0,092605 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06307602 0,09254938 ! regulation of heart rate GO:0002027 25 14 0,000 0,06307602 0,09249382 ! organic alcohol transport GO:0015850 29 14 0,000 0,06307602 0,09243834 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06307602 0,09238292 ! embryo implantation GO:0007566 30 14 0,000 0,06307602 0,09232757 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06307602 0,09227228 ! bone mineralization GO:0030282 18 14 0,000 0,06307602 0,09221706 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06307602 0,09216191 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06307602 0,09210682 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06307602 0,0920518 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06307602 0,09199684 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,06307602 0,09194195 ! ribosome assembly GO:0042255 18 14 0,000 0,06307602 0,09188713 ! cerebellum development GO:0021549 23 14 0,000 0,06307602 0,09183237 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06307602 0,09177767 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,06307602 0,09172304 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06307602 0,09166848 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06307602 0,09161398 ! NADP metabolic process GO:0006739 24 14 0,000 0,06307602 0,09155954 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,06307602 0,09150517 ! oxygen transport GO:0015671 22 14 0,000 0,06307602 0,09145087 ! male genitalia development GO:0030539 26 14 0,000 0,06307602 0,09139663 ! regulation of axon extension GO:0030516 43 14 0,000 0,06307602 0,09134245 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,06307602 0,09128834 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,06307602 0,09123429 ! tube morphogenesis GO:0035239 194 89 1,000 0,06453504 0,09328941 ! regulation of neurological system process GO:0031644 175 89 1,000 0,06453504 0,09323424 ! lactation GO:0007595 30 15 0,000 0,06742706 0,09735479 ! reproductive cellular process GO:0048610 22 15 0,000 0,06742706 0,09729728 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06742706 0,09723985 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,06742706 0,09718248 ! superoxide anion generation GO:0042554 22 15 0,000 0,06742706 0,09712518 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,06742706 0,09706795 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,06742706 0,09701078 ! copper ion transport GO:0006825 22 15 0,000 0,06742706 0,09695368 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,06742706 0,09689665 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,06742706 0,09683968 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,06742706 0,09678279 ! sulfate transport GO:0008272 27 15 0,000 0,06742706 0,09672596 ! response to cAMP GO:0051591 25 15 0,000 0,06742706 0,09666919 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,06742706 0,09661249 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,06742706 0,09655586 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,06742706 0,0964993 ! response to hexose stimulus GO:0009746 25 15 0,000 0,06742706 0,0964428 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,06742706 0,09638637 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,06742706 0,09633 ! vesicle coating GO:0006901 38 15 0,000 0,06742706 0,0962737 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,06742706 0,09621747 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,06742706 0,0961613 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,06742706 0,09610519 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,06742706 0,09604916 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,06742706 0,09599318 ! histone deacetylation GO:0016575 24 15 0,000 0,06742706 0,09593728 ! water homeostasis GO:0030104 28 15 0,000 0,06742706 0,09588143 ! cofactor transport GO:0051181 30 15 0,000 0,06742706 0,09582566 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06742706 0,09576994 ! muscle maintenance GO:0046716 26 15 0,000 0,06742706 0,0957143 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,06742706 0,09565871 ! intestinal absorption GO:0050892 31 15 0,000 0,06742706 0,09560319 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06742706 0,09554774 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,06742706 0,09549235 ! heme biosynthetic process GO:0006783 33 15 0,000 0,06742706 0,09543702 ! cell killing GO:0001906 32 15 0,000 0,06742706 0,09538176 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,06742706 0,09532656 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,06742706 0,09527143 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,06742706 0,09521636 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,06742706 0,09516135 ! actin filament polymerization GO:0030041 27 15 0,000 0,06742706 0,09510641 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,06742706 0,09505153 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,06967076 0,09815782 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,07097511 0,09993786 ! female pregnancy GO:0007565 166 94 1,000 0,07097511 0,09988029 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,07097511 0,09982279 ! regulation of membrane potential GO:0042391 179 94 1,000 0,07097511 0,09976535 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,07175801 0,10080784 ! positive regulation of cell size GO:0045793 29 16 0,000 0,07175801 0,1007499 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,07175801 0,10069203 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,07175801 0,10063423 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,07175801 0,10057649 ! bone remodeling GO:0046849 28 16 0,000 0,07175801 0,10051882 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,07175801 0,10046122 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,07175801 0,10040368 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07175801 0,10034621 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,07175801 0,1002888 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,07175801 0,10023146 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,07175801 0,10017419 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,07175801 0,10011698 ! startle response GO:0001964 28 16 0,000 0,07175801 0,10005983 ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,07175801 0,10000275 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,07175801 0,09994574 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,07175801 0,09988879 ! protein polyubiquitination GO:0000209 41 16 0,000 0,07175801 0,09983191 ! glutamate metabolic process GO:0006536 25 16 0,000 0,07175801 0,09977509 ! pituitary gland development GO:0021983 30 16 0,000 0,07175801 0,09971833 ! response to osmotic stress GO:0006970 27 16 0,000 0,07175801 0,09966164 ! lysosomal transport GO:0007041 31 16 0,000 0,07175801 0,09960502 ! fructose metabolic process GO:0006000 25 16 0,000 0,07175801 0,09954845 ! L-amino acid transport GO:0015807 33 16 0,000 0,07175801 0,09949196 ! stem cell development GO:0048864 46 16 0,000 0,07175801 0,09943552 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07175801 0,09937915 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,07175801 0,09932285 ! intermediate filament-based process GO:0045103 36 16 0,000 0,07175801 0,09926661 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,07175801 0,09921043 ! negative regulation of immune response GO:0050777 38 16 0,000 0,07175801 0,09915431 ! axon cargo transport GO:0008088 46 16 0,000 0,07175801 0,09909826 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,07175801 0,09904228 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,07175801 0,09898635 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,07175801 0,09893049 ! DNA replication initiation GO:0006270 28 16 0,000 0,07175801 0,09887469 ! neuron recognition GO:0008038 40 16 0,000 0,07175801 0,09881896 ! mRNA splice site selection GO:0006376 44 16 0,000 0,07175801 0,09876328 ! tissue regeneration GO:0042246 27 16 0,000 0,07175801 0,09870767 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,07175801 0,09865213 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,07175801 0,09859664 ! biomineral formation GO:0031214 22 16 0,000 0,07175801 0,09854122 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,07175801 0,09848586 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,07175801 0,09843056 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,07175801 0,09837532 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07175801 0,09832015 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,07175801 0,09826504 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,07175801 0,09820999 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,07175801 0,098155 ! peptide hormone processing GO:0016486 27 16 0,000 0,07175801 0,09810007 ! regulation of T cell activation GO:0050863 175 96 1,000 0,07360759 0,10057234 ! regulation of protein localization GO:0032880 188 97 1,000 0,07493553 0,10232951 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,07606898 0,10381928 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,07606898 0,10376131 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,07606898 0,10370341 ! signal complex assembly GO:0007172 47 17 0,000 0,07606898 0,10364557 ! endothelial cell migration GO:0043542 31 17 0,000 0,07606898 0,1035878 ! gene silencing by RNA GO:0031047 38 17 0,000 0,07606898 0,10353009 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,07606898 0,10347245 ! glial cell development GO:0021782 28 17 0,000 0,07606898 0,10341487 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,07606898 0,10335735 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,07606898 0,1032999 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,07606898 0,10324251 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,07606898 0,10318518 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,07606898 0,10312792 ! myoblast differentiation GO:0045445 50 17 0,000 0,07606898 0,10307072 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,07606898 0,10301359 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,07606898 0,10295652 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,07606898 0,10289951 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,07606898 0,10284256 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,07606898 0,10278568 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,07606898 0,10272886 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,07606898 0,10267211 ! membrane budding GO:0006900 42 17 0,000 0,07606898 0,10261541 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,07606898 0,10255878 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,07606898 0,10250221 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,07606898 0,10244571 ! genitalia development GO:0048806 32 17 0,000 0,07606898 0,10238926 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,07606898 0,10233288 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,07606898 0,10227656 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,07606898 0,1022203 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,07606898 0,10216411 ! steroid catabolic process GO:0006706 34 17 0,000 0,07606898 0,10210797 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,07606898 0,1020519 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,07606898 0,10199589 ! gas transport GO:0015669 26 17 0,000 0,07606898 0,10193994 ! organic cation transport GO:0015695 32 17 0,000 0,07606898 0,10188405 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,07606898 0,10182823 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,07606898 0,10177246 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,07896492 0,10558911 GO:0060538|skeletal muscle organ development, ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,08036004 0,10739583 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,08036004 0,10733711 ! limbic system development GO:0021761 40 18 0,000 0,08036004 0,10727846 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,08036004 0,10721987 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,08036004 0,10716134 ! adult walking behavior GO:0007628 36 18 0,000 0,08036004 0,10710288 ! patterning of blood vessels GO:0001569 43 18 0,000 0,08036004 0,10704448 ! heart looping GO:0001947 34 18 0,000 0,08036004 0,10698615 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,08036004 0,10692788 ! centrosome cycle GO:0007098 26 18 0,000 0,08036004 0,10686967 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,08036004 0,10681152 ! glycine metabolic process GO:0006544 30 18 0,000 0,08036004 0,10675344 ! glutamine metabolic process GO:0006541 29 18 0,000 0,08036004 0,10669543 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,08036004 0,10663747 ! DNA integration GO:0015074 32 18 0,000 0,08036004 0,10657958 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,08036004 0,10652175 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,08036004 0,10646398 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,08036004 0,10640628 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,08036004 0,10634864 ! neural crest cell migration GO:0001755 41 18 0,000 0,08036004 0,10629106 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,08036004 0,10623354 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,08036004 0,10617609 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,08036004 0,10611869 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,08036004 0,10606136 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,08036004 0,10600409 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,08036004 0,10594689 ! detection of bacterium GO:0016045 22 18 0,000 0,08036004 0,10588974 ! nerve development GO:0021675 34 18 0,000 0,08036004 0,10583266 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,08036004 0,10577564 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,08036004 0,10571868 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,0846313 0,11127786 ! positive regulation of translation GO:0045727 31 19 0,000 0,0846313 0,111218 ! negative regulation of defense response GO:0031348 27 19 0,000 0,0846313 0,1111582 ! neuron maturation GO:0042551 46 19 0,000 0,0846313 0,11109847 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,0846313 0,11103881 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,0846313 0,1109792 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,0846313 0,11091967 GO:0019692|deoxyribose phosphate metabolic process, ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,0846313 0,11086019 ! inositol metabolic process GO:0006020 33 19 0,000 0,0846313 0,11080078 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,0846313 0,11074143 ! memory GO:0007613 34 19 0,000 0,0846313 0,11068215 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,0846313 0,11062293 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,0846313 0,11056377 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,0846313 0,11050468 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,0846313 0,11044565 ! cerebral cortex development GO:0021987 40 19 0,000 0,0846313 0,11038668 ! neuromuscular junction development GO:0007528 43 19 0,000 0,0846313 0,11032778 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,0846313 0,11026894 ! response to fungus GO:0009620 26 19 0,000 0,0846313 0,11021016 ! peptide cross-linking GO:0018149 39 19 0,000 0,0846313 0,11015144 ! heart process GO:0003015 32 19 0,000 0,0846313 0,11009279 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,0846313 0,1100342 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,0846313 0,10997567 ! visual learning GO:0008542 38 19 0,000 0,0846313 0,1099172 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,0846313 0,1098588 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,0846313 0,10980046 ! vitamin transport GO:0051180 31 19 0,000 0,0846313 0,10974217 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,0846313 0,10968396 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,0846313 0,1096258 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,0846313 0,1095677 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,0846313 0,10950967 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,0846313 0,1094517 ! cilium assembly GO:0042384 38 19 0,000 0,0846313 0,10939379 ! peptide hormone secretion GO:0030072 32 19 0,000 0,0846313 0,10933594 ! protein secretion GO:0009306 45 20 0,000 0,08888283 0,11476784 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,08888283 0,11470722 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,08888283 0,11464665 ! positive regulation of ossification GO:0045778 50 20 0,000 0,08888283 0,11458615 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,08888283 0,11452572 ! skin development GO:0043588 42 20 0,000 0,08888283 0,11446535 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,08888283 0,11440504 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,08888283 0,11434479 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,08888283 0,11428461 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,08888283 0,11422449 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,08888283 0,11416444 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,08888283 0,11410445 ! bile acid metabolic process GO:0008206 34 20 0,000 0,08888283 0,11404452 ! retinoid metabolic process GO:0001523 34 20 0,000 0,08888283 0,11398465 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,08888283 0,11392485 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,08888283 0,11386511 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,08888283 0,11380543 GO:0032392|DNA geometric change, ! body fluid secretion GO:0007589 33 20 0,000 0,08888283 0,11374582 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,08888283 0,11368626 ! peptide secretion GO:0002790 38 20 0,000 0,08888283 0,11362677 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,08888283 0,11356734 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,08888283 0,11350798 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,08888283 0,11344867 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,08888283 0,11338943 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,08888283 0,11333025 ! cell-cell junction organization GO:0045216 43 20 0,000 0,08888283 0,11327113 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,08888283 0,11321208 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,08888283 0,11315308 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,08888283 0,11309415 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,08888283 0,11303527 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,08888283 0,11297646 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,08888283 0,11291771 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,08888283 0,11285902 ! regulation of cell killing GO:0031341 46 21 0,000 0,09311474 0,11817107 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,09311474 0,11810972 ! hormone secretion GO:0046879 39 21 0,000 0,09311474 0,11804842 ! cAMP metabolic process GO:0046058 41 21 0,000 0,09311474 0,1179872 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,09311474 0,11792603 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,09311474 0,11786493 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,09311474 0,11780389 ! smooth muscle contraction GO:0006939 48 21 0,000 0,09311474 0,11774292 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,09311474 0,117682 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,09311474 0,11762116 ! plasma membrane fusion GO:0045026 33 21 0,000 0,09311474 0,11756037 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,09311474 0,11749965 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,09311474 0,11743899 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,09311474 0,11737839 ! sensory perception of pain GO:0019233 33 21 0,000 0,09311474 0,11731785 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,09311474 0,11725738 ! diencephalon development GO:0021536 36 21 0,000 0,09311474 0,11719697 ! collagen fibril organization GO:0030199 62 21 0,000 0,09311474 0,11713662 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,09311474 0,11707633 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,09311474 0,11701611 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,09311474 0,11695595 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,09311474 0,11689585 ! collagen catabolic process GO:0030574 29 21 0,000 0,09311474 0,11683581 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,09311474 0,11677583 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,09311474 0,11671591 ! sperm-egg recognition GO:0035036 23 21 0,000 0,09311474 0,11665606 ! actin filament-based movement GO:0030048 47 21 0,000 0,09311474 0,11659627 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,09732711 0,12180847 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,09732711 0,1217461 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,09732711 0,1216838 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,09732711 0,12162155 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,09732711 0,12155938 ! microtubule-based transport GO:0010970 59 22 0,000 0,09732711 0,12149726 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,09732711 0,12143521 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,09732711 0,12137322 ! vacuolar transport GO:0007034 41 22 0,000 0,09732711 0,12131129 ! central nervous system neuron development GO:0021954 47 22 0,000 0,09732711 0,12124943 ! fucose metabolic process GO:0006004 44 22 0,000 0,09732711 0,12118763 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,09732711 0,1211259 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,09732711 0,12106423 ! stem cell differentiation GO:0048863 57 22 0,000 0,09732711 0,12100261 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,09732711 0,12094107 ! cytolysis GO:0019835 27 22 0,000 0,09732711 0,12087958 ! vasodilation GO:0042311 40 22 0,000 0,09732711 0,12081816 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,09732711 0,1207568 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,09732711 0,1206955 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,09732711 0,12063427 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,09732711 0,12057309 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,09732711 0,12051198 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,09732711 0,12045093 ! sarcomere organization GO:0045214 32 22 0,000 0,09732711 0,12038994 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,09732711 0,12032902 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,09732711 0,12026815 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,09732711 0,12020735 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,09732711 0,12014661 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,09732711 0,12008593 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,10152004 0,12519609 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,10152004 0,12513292 ! gluconeogenesis GO:0006094 38 23 0,000 0,10152004 0,12506982 ! glycerol metabolic process GO:0006071 40 23 0,000 0,10152004 0,12500678 ! viral genome replication GO:0019079 44 23 0,000 0,10152004 0,1249438 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,10152004 0,12488089 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,10152004 0,12481804 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,10152004 0,12475526 ! axis specification GO:0009798 43 23 0,000 0,10152004 0,12469253 ! visual behavior GO:0007632 46 23 0,000 0,10152004 0,12462987 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,10152004 0,12456728 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,10152004 0,12450474 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,10152004 0,12444227 ! peroxisome organization GO:0007031 43 23 0,000 0,10152004 0,12437986 ! lysosome organization GO:0007040 47 23 0,000 0,10152004 0,12431752 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,10152004 0,12425524 ! vesicle targeting GO:0006903 49 23 0,000 0,10152004 0,12419301 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,10152004 0,12413086 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,10152004 0,12406876 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,10152004 0,12400672 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,10152004 0,12394475 ! DNA modification GO:0006304 36 23 0,000 0,10152004 0,12388284 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,10152004 0,12382099 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,10152004 0,12375921 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,10152004 0,12369748 ! hormone transport GO:0009914 41 23 0,000 0,10152004 0,12363582 ! cell-cell recognition GO:0009988 28 23 0,000 0,10152004 0,12357422 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,10152004 0,12351267 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,10152004 0,12345119 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,1056936 0,12846242 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,1056936 0,12839854 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,1056936 0,12833473 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,1056936 0,12827097 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,1056936 0,12820728 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,1056936 0,12814366 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,1056936 0,12808009 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,1056936 0,12801659 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,1056936 0,12795316 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,1056936 0,12788978 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,1056936 0,12782647 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,1056936 0,12776322 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,1056936 0,12770003 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,1056936 0,12763691 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,1056936 0,12757385 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,1056936 0,12751085 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,1056936 0,12744791 ! membrane depolarization GO:0051899 45 24 0,000 0,1056936 0,12738504 ! pallium development GO:0021543 56 24 0,000 0,1056936 0,12732222 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,1056936 0,12725947 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,1056936 0,12719678 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,1056936 0,12713415 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,1056936 0,12707159 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,1056936 0,12700908 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,1056936 0,12694664 ! regulation of amine transport GO:0051952 41 24 0,000 0,1056936 0,12688426 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,1056936 0,12682194 ! leukocyte adhesion GO:0007159 55 25 0,000 0,1098479 0,13174198 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,1098479 0,13167734 ! phototransduction GO:0007602 37 25 0,000 0,1098479 0,13161276 ! keratinization GO:0031424 37 25 0,000 0,1098479 0,13154824 ! vacuole organization GO:0007033 49 25 0,000 0,1098479 0,13148379 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,1098479 0,1314194 ! receptor metabolic process GO:0043112 53 25 0,000 0,1098479 0,13135507 ! chromosome condensation GO:0030261 48 25 0,000 0,1098479 0,13129081 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,1098479 0,13122661 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,1098479 0,13116247 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,1098479 0,13109839 ! immunoglobulin production GO:0002377 62 25 0,000 0,1098479 0,13103438 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,1098479 0,13097043 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,1098479 0,13090654 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,11398301 0,13576816 ! myelination GO:0042552 50 26 0,000 0,11398301 0,13570199 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,11398301 0,1356359 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,11398301 0,13556986 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,11398301 0,13550389 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,11398301 0,13543798 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,11398301 0,13537214 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,11398301 0,13530636 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,11398301 0,13524065 ! digestive system process GO:0022600 49 26 0,000 0,11398301 0,135175 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,11398301 0,13510941 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,11398301 0,13504389 ! osteoblast differentiation GO:0001649 63 26 0,000 0,11398301 0,13497843 ! neural crest cell development GO:0014032 59 26 0,000 0,11398301 0,13491303 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,11398301 0,1348477 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,11398301 0,13478243 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,11398301 0,13471722 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,11398301 0,13465208 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,11398301 0,134587 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,11398301 0,13452198 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,11398301 0,13445702 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,11398301 0,13439213 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,11398301 0,1343273 ! blastocyst development GO:0001824 50 26 0,000 0,11398301 0,13426253 ! telomere organization GO:0032200 46 26 0,000 0,11398301 0,13419783 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,11398301 0,13413319 ! neural tube closure GO:0001843 58 26 0,000 0,11398301 0,13406861 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,11398301 0,13400409 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,11398301 0,13393963 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,11398301 0,13387524 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,11809903 0,13864293 ! embryonic pattern specification GO:0009880 49 27 0,000 0,11809903 0,13857634 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,11809903 0,13850981 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,11809903 0,13844334 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,11809903 0,13837695 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,11809903 0,13831061 ! iron ion transport GO:0006826 65 27 0,000 0,11809903 0,13824434 ! superoxide metabolic process GO:0006801 41 27 0,000 0,11809903 0,13817813 ! tube lumen formation GO:0035148 59 27 0,000 0,11809903 0,13811198 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,11809903 0,1380459 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,11809903 0,13797988 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,11809903 0,13791392 ! neuron fate commitment GO:0048663 52 28 0,000 0,12219604 0,14263017 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,12219604 0,14256205 ! vesicle docking GO:0048278 55 28 0,000 0,12219604 0,142494 ! circadian rhythm GO:0007623 56 28 0,000 0,12219604 0,14242602 ! dendrite development GO:0016358 67 28 0,000 0,12219604 0,1423581 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,12219604 0,14229025 ! sperm motility GO:0030317 37 28 0,000 0,12219604 0,14222246 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,12219604 0,14215473 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,12219604 0,14208707 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,12219604 0,14201948 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,12219604 0,14195194 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,12219604 0,14188448 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,12219604 0,14181707 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,12219604 0,14174973 ! glutathione metabolic process GO:0006749 42 28 0,000 0,12219604 0,14168246 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,12219604 0,14161525 ! lipid oxidation GO:0034440 48 28 0,000 0,12219604 0,1415481 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,12219604 0,14148101 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,12219604 0,14141399 ! translational initiation GO:0006413 66 29 0,000 0,12627414 0,14606426 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,12627414 0,14599514 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,12627414 0,14592608 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! autophagy GO:0006914 47 29 0,000 0,12627414 0,14585708 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,12627414 0,14578815 ! primary neural tube formation GO:0014020 61 29 0,000 0,12627414 0,14571928 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,12627414 0,14565048 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,12627414 0,14558175 ! synaptogenesis GO:0007416 46 29 0,000 0,12627414 0,14551308 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,12627414 0,14544447 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,12627414 0,14537593 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,1303334 0,14997857 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,1303334 0,14990796 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,1303334 0,14983742 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,1303334 0,14976694 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,1303334 0,14969652 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,1303334 0,14962618 ! acute-phase response GO:0006953 50 30 0,000 0,1303334 0,1495559 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,1303334 0,14948568 ! myofibril assembly GO:0030239 50 30 0,000 0,1303334 0,14941554 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,1303334 0,14934545 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,1303334 0,14927544 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,1303334 0,14920549 ! cell fate determination GO:0001709 64 30 0,000 0,1303334 0,1491356 ! phospholipid transport GO:0015914 65 30 0,000 0,1303334 0,14906578 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,1303334 0,14899603 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,1303334 0,14892634 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,1303334 0,14885671 ! regulation of coagulation GO:0050818 52 30 0,000 0,1303334 0,14878715 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,13437392 0,15332812 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,13437392 0,15325653 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,13437392 0,15318502 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,13437392 0,15311357 ! regulation of innate immune response GO:0045088 57 31 0,000 0,13437392 0,15304219 ! peptide transport GO:0015833 60 31 0,000 0,13437392 0,15297087 ! detection of light stimulus GO:0009583 44 31 0,000 0,13437392 0,15289963 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,13437392 0,15282844 ! natural killer cell activation GO:0030101 50 31 0,000 0,13437392 0,15275733 ! ensheathment of neurons GO:0007272 64 31 0,000 0,13437392 0,15268628 GO:0008366|axon ensheathment, ! fatty acid catabolic process GO:0009062 54 31 0,000 0,13437392 0,15261529 ! eye morphogenesis GO:0048592 65 31 0,000 0,13437392 0,15254438 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,13437392 0,15247352 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,13839578 0,15696421 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,13839578 0,15689137 ! collagen metabolic process GO:0032963 49 32 0,000 0,13839578 0,1568186 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,13839578 0,1567459 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,13839578 0,15667326 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,13839578 0,15660069 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,13839578 0,15652819 ! muscle cell development GO:0055001 52 32 0,000 0,13839578 0,15645576 ! mesoderm formation GO:0001707 73 32 0,000 0,13839578 0,15638339 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,13839578 0,15631109 ! peripheral nervous system development GO:0007422 68 32 0,000 0,13839578 0,15623886 ! BMP signaling pathway GO:0030509 71 32 0,000 0,13839578 0,1561667 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,13839578 0,1560946 ! gene silencing GO:0016458 71 32 0,000 0,13839578 0,15602256 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,14239907 0,16046168 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,14239907 0,1603877 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,14239907 0,16031379 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,14239907 0,16023995 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,14239907 0,16016617 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,14239907 0,16009246 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,14239907 0,16001883 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,14239907 0,15994525 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,14239907 0,15987175 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,14239907 0,15979831 ! glial cell differentiation GO:0010001 67 34 0,000 0,14638387 0,16419458 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,14638387 0,16411922 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,14638387 0,16404394 ! spliceosome assembly GO:0000245 75 34 0,000 0,14638387 0,16396872 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,14638387 0,16389358 ! formation of primary germ layer GO:0001704 76 34 0,000 0,14638387 0,1638185 ! cell fate specification GO:0001708 56 34 0,000 0,14638387 0,16374349 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,14638387 0,16366855 ! adult locomotory behavior GO:0008344 62 34 0,000 0,14638387 0,16359368 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,15035026 0,16794956 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,15035026 0,1678728 ! membrane docking GO:0022406 69 35 0,000 0,15035026 0,16779611 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,15035026 0,16771949 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,15035026 0,16764294 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,15035026 0,16756646 ! ceramide metabolic process GO:0006672 72 35 0,000 0,15035026 0,16749005 ! telencephalon development GO:0021537 81 35 0,000 0,15035026 0,16741371 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,15035026 0,16733744 ! vesicle localization GO:0051648 70 35 0,000 0,15035026 0,16726124 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,15429834 0,17157526 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,15429834 0,1714972 ! protein targeting to membrane GO:0006612 75 36 0,000 0,15429834 0,17141921 ! aerobic respiration GO:0009060 56 36 0,000 0,15429834 0,17134129 ! cytokine production GO:0001816 68 36 0,000 0,15429834 0,17126344 ! embryonic organ development GO:0048568 67 36 0,000 0,15429834 0,17118567 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,15429834 0,17110796 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,15429834 0,17103033 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,15822818 0,17530677 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,15822818 0,17522731 ! odontogenesis GO:0042476 74 37 0,000 0,15822818 0,17514791 ! actomyosin structure organization GO:0031032 68 37 0,000 0,15822818 0,17506859 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,15822818 0,17498933 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,15822818 0,17491015 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,15822818 0,17483104 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,16213987 0,17907219 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,16213987 0,17899128 ! organic anion transport GO:0015711 82 38 0,000 0,16213987 0,17891043 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,16213987 0,17882966 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,16213987 0,17874896 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,16213987 0,17866833 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,16213987 0,17858778 ! spermatid development GO:0007286 69 38 0,000 0,16213987 0,1785073 ! neural tube formation GO:0001841 79 38 0,000 0,16213987 0,17842689 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,16603349 0,18262936 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,16603349 0,18254717 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,16603349 0,18246505 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,16603349 0,18238301 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,16603349 0,18230104 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,16603349 0,18221914 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,16990912 0,18638886 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,16990912 0,1863052 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,16990912 0,18622162 ! lipid homeostasis GO:0055088 75 40 0,000 0,16990912 0,18613811 ! mismatch repair GO:0006298 58 40 0,000 0,16990912 0,18605468 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,16990912 0,18597132 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,16990912 0,18588804 ! RNA export from nucleus GO:0006405 61 41 0,000 0,17376686 0,19002347 ! mRNA catabolic process GO:0006402 79 41 0,000 0,17376686 0,18993845 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,17376686 0,1898535 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,17376686 0,18976863 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,17376686 0,18968384 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,17376686 0,18959912 ! gliogenesis GO:0042063 91 41 0,000 0,17376686 0,18951448 ! feeding behavior GO:0007631 69 41 0,000 0,17376686 0,18942991 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,17376686 0,18934542 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,17376686 0,18926101 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,17376686 0,18917666 ! spermatid differentiation GO:0048515 73 41 0,000 0,17376686 0,1890924 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,17376686 0,18900821 ! RNA modification GO:0009451 64 41 0,000 0,17376686 0,18892409 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,17760677 0,19301305 ! ear morphogenesis GO:0042471 64 42 0,000 0,17760677 0,19292723 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,17760677 0,19284149 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,17760677 0,19275582 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,17760677 0,19267022 ! regulation of protein secretion GO:0050708 77 42 0,000 0,17760677 0,19258471 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,17760677 0,19249927 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,17760677 0,1924139 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,18142895 0,19646761 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,18142895 0,19638056 ! regulation of tube size GO:0035150 76 43 0,000 0,18142895 0,19629359 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,18142895 0,19620669 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,18142895 0,19611988 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,18142895 0,19603314 ! ion transmembrane transport GO:0034220 79 43 0,000 0,18142895 0,19594647 ! neuron migration GO:0001764 85 43 0,000 0,18142895 0,19585989 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,18523347 0,19987869 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,18523347 0,19979045 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,18523347 0,19970228 ! striated muscle contraction GO:0006941 85 44 0,000 0,18523347 0,19961419 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,18523347 0,19952617 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,18902041 0,20351558 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,18902041 0,20342593 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,18902041 0,20333635 ! biopolymer methylation GO:0043414 91 45 0,000 0,18902041 0,20324686 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,18902041 0,20315744 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,18902041 0,2030681 ! polyol metabolic process GO:0019751 77 45 0,000 0,18902041 0,20297884 ! maintenance of location in cell GO:0051651 101 45 0,000 0,18902041 0,20288966 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,19278986 0,20684481 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,19278986 0,206754 ! glycolysis GO:0006096 71 46 0,000 0,19278986 0,20666328 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,19278986 0,20657264 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,19278986 0,20648208 ! neural tube development GO:0021915 91 47 0,000 0,19654189 0,21040834 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,19654189 0,21031618 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,20027659 0,21421879 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,20027659 0,21412504 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,20027659 0,21403137 ! endosome transport GO:0016197 127 48 0,000 0,20027659 0,21393778 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,20027659 0,21384428 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,20027659 0,21375086 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,20027659 0,21365751 ! methylation GO:0032259 97 48 0,000 0,20027659 0,21356426 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,20399403 0,21743343 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,20399403 0,21733861 ! regulation of action potential GO:0001508 102 50 0,000 0,2076943 0,22118447 ! regulation of ion transport GO:0043269 86 50 0,000 0,2076943 0,22108809 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,2076943 0,2209918 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,2076943 0,22089559 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,2076943 0,22079947 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,2076943 0,22070343 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,2076943 0,22060747 ! peptide metabolic process GO:0006518 80 51 0,000 0,21137747 0,22442206 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,21137747 0,22432457 ! Notch signaling pathway GO:0007219 111 52 0,000 0,21504362 0,22811618 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,21504362 0,22801717 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,21504362 0,22791825 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,21504362 0,22781941 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,21504362 0,22772066 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,21504362 0,227622 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,21504362 0,22752342 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,21504362 0,22742492 ! amino acid activation GO:0043038 98 52 0,000 0,21504362 0,22732651 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,21869283 0,23108417 ! inner ear development GO:0048839 89 53 0,000 0,21869283 0,23098426 ! chromatin remodeling GO:0006338 122 53 0,000 0,21869283 0,23088444 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,21869283 0,2307847 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,21869283 0,23068506 ! synapse organization GO:0050808 102 53 0,000 0,21869283 0,23058549 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,22232518 0,23431424 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,22232518 0,2342132 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,22232518 0,23411225 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,22232518 0,23401138 ! membrane fusion GO:0006944 122 54 0,000 0,22232518 0,2339106 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,22232518 0,23380991 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,22232518 0,2337093 ! RNA catabolic process GO:0006401 103 55 0,000 0,22594074 0,23740784 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,22594074 0,23730578 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,22594074 0,2372038 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,22594074 0,23710191 ! cell recognition GO:0008037 98 55 0,000 0,22594074 0,2370001 ! cell maturation GO:0048469 107 55 0,000 0,22594074 0,23689839 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,22594074 0,23679676 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,2295396 0,24046537 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,2295396 0,2403623 ! glucose catabolic process GO:0006007 88 56 0,000 0,2295396 0,24025932 ! RNA elongation GO:0006354 90 56 0,000 0,2295396 0,24015642 ! chloride transport GO:0006821 102 57 0,000 0,23312182 0,24379992 ! muscle fiber development GO:0048747 131 57 0,000 0,23312182 0,2436956 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,23312182 0,24359137 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,23312182 0,24348722 ! regulation of actin filament length GO:0030832 118 58 0,000 0,23668749 0,24710579 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,23668749 0,24700023 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,23668749 0,24689477 ! gastrulation GO:0007369 122 58 0,000 0,23668749 0,24678939 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,23668749 0,24668411 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,24376947 0,25395685 ! adult behavior GO:0030534 104 60 0,000 0,24376947 0,2538486 ! positive regulation of secretion GO:0051047 110 61 0,000 0,24728593 0,25740074 ! regulation of cellular component size GO:0032535 125 61 0,000 0,24728593 0,25729111 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,24728593 0,25718158 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,24728593 0,25707214 ! proton transport GO:0015992 117 61 0,000 0,24728593 0,25696279 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,25078614 0,26048917 ! tRNA processing GO:0008033 102 62 0,000 0,25078614 0,26037847 ! mesoderm development GO:0007498 128 63 0,000 0,25427016 0,26388361 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,25427016 0,26377155 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,25427016 0,2636596 ! hydrogen transport GO:0006818 121 64 0,000 0,25773809 0,26714219 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,25773809 0,2670289 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,25773809 0,26691571 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,26118998 0,2703759 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,26118998 0,27026138 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,26118998 0,27014696 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,26804598 0,27712075 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,26804598 0,27700352 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,27145022 0,28040291 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,27145022 0,2802844 ! hexose catabolic process GO:0019320 113 68 0,000 0,27145022 0,28016599 ! extracellular matrix organization GO:0030198 146 68 0,000 0,27145022 0,28004767 ! detection of external stimulus GO:0009581 102 68 0,000 0,27145022 0,27992946 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,27145022 0,27981135 ! regulation of lipase activity GO:0060191 137 68 0,000 0,27145022 0,27969333 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,27483873 0,28306535 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,27483873 0,28294607 ! single fertilization GO:0007338 83 69 0,000 0,27483873 0,28282688 ! cell redox homeostasis GO:0045454 114 70 0,000 0,27821157 0,28617721 ! activation of immune response GO:0002253 120 70 0,000 0,27821157 0,28605676 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,27821157 0,28593642 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,28156882 0,2892652 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,28156882 0,2891436 ! appendage morphogenesis GO:0035107 150 72 0,000 0,28491055 0,2924523 GO:0035108|limb morphogenesis, ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,28491055 0,29232947 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,28491055 0,29220675 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,28491055 0,29208413 ! appendage development GO:0048736 151 73 0,000 0,28823683 0,29537021 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,28823683 0,29524636 ! acute inflammatory response GO:0002526 118 74 0,000 0,29154773 0,29851262 ! amino acid transport GO:0006865 148 74 0,000 0,29154773 0,29838756 ! transition metal ion transport GO:0000041 143 75 0,000 0,29484332 0,3016341 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,29484332 0,30150784 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,29484332 0,30138169 ! axon guidance GO:0007411 162 75 0,000 0,29484332 0,30125564 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,29812368 0,30447999 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,29812368 0,30435275 ! amine catabolic process GO:0009310 136 77 0,000 0,30138886 0,30755764 ! neurotransmitter transport GO:0006836 142 77 0,000 0,30138886 0,30742922 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,30138886 0,30730091 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,30138886 0,30717271 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,30463895 0,31035569 ! fertilization GO:0009566 99 78 0,000 0,30463895 0,31022632 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,30787401 0,31339008 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,30787401 0,31325956 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,3110941 0,3164042 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,3110941 0,31627253 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,31429931 0,31939818 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,32066533 0,32573197 ! exocytosis GO:0006887 153 83 0,000 0,32066533 0,32559659 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,32066533 0,32546132 ! inorganic anion transport GO:0015698 156 83 0,000 0,32066533 0,32532616 ! digestion GO:0007586 130 84 0,000 0,32382627 0,32839667 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,32697259 0,33144981 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,32697259 0,33131234 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,33010437 0,334347 ! regulation of lyase activity GO:0051339 169 86 0,000 0,33010437 0,33420844 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,33322165 0,33722473 ! alcohol catabolic process GO:0046164 142 87 0,000 0,33322165 0,33708509 ! nucleosome assembly GO:0006334 126 87 0,000 0,33322165 0,33694557 ! regulation of protein transport GO:0051223 165 87 0,000 0,33322165 0,33680617 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,33632452 0,33980182 ! sensory perception of smell GO:0007608 117 88 0,000 0,33632452 0,33966135 ! chromatin assembly GO:0031497 128 88 0,000 0,33632452 0,339521 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,33632452 0,33938076 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,33941304 0,34235593 ! cellular defense response GO:0006968 123 89 0,000 0,33941304 0,34221463 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,34248727 0,34517178 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,34554728 0,34811217 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,34554728 0,34796868 ! defense response to bacterium GO:0042742 112 91 0,000 0,34554728 0,3478253 ! bone development GO:0060348 206 92 0,000 0,34859314 0,35074672 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,34859314 0,35060232 ! amine transport GO:0015837 181 93 0,000 0,3516249 0,35350602 ! vitamin metabolic process GO:0006766 153 93 0,000 0,3516249 0,35336061 ! sterol metabolic process GO:0016125 166 94 0,000 0,35464264 0,3562467 ! nucleosome organization GO:0034728 143 95 0,000 0,35764642 0,3591164 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,35764642 0,35896886 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,35764642 0,35882144 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,35764642 0,35867414 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,35764642 0,35852696 ! transcription initiation GO:0006352 171 97 0,000 0,36361235 0,36435807 ! forebrain development GO:0030900 210 98 0,000 0,36657463 0,36717582 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,36657463 0,36702534 ! mRNA transport GO:0051028 185 100 0,000 0,37245814 0,37276331 ! positive regulation of immune response GO:0050778 175 100 0,000 0,37245814 0,37261066 ! hormone metabolic process GO:0042445 171 100 0,000 0,37245814 0,37245814