pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1135-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 3,000 8,443E-08 1,942E-04 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 6,000 8,637E-08 9,933E-05 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 4,000 1,025E-07 7,856E-05 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 6,000 1,205E-07 6,928E-05 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 6,000 1,205E-07 5,542E-05 ! positive regulation of ligase activity GO:0051351 99 69 6,000 1,831E-07 7,018E-05 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 6,000 2,235E-07 7,343E-05 ! regulation of ligase activity GO:0051340 114 75 6,000 3,27E-07 9,402E-05 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 1,72E-06 4,396E-04 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 5,000 1,727E-06 3,971E-04 ! nuclear migration GO:0007097 10 5 2,000 2,087E-06 4,364E-04 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 2,000 2,087E-06 4E-04 ! positive regulation of mast cell activation GO:0033005 5 5 2,000 2,087E-06 3,693E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 2,087E-06 3,429E-04 GO:0031272|regulation of pseudopodium assembly, ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 2,753E-06 4,222E-04 ! positive regulation of exocytosis GO:0045921 6 6 2,000 4,156E-06 5,974E-04 ! macrophage differentiation GO:0030225 10 6 2,000 4,156E-06 5,623E-04 ! regulation of mast cell activation GO:0033003 6 6 2,000 4,156E-06 5,31E-04 ! calcium-independent cell-cell adhesion GO:0016338 21 19 3,000 4,443E-06 5,378E-04 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 5,409E-06 6,22E-04 ! response to insulin stimulus GO:0032868 63 43 4,000 5,701E-06 6,244E-04 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 7,168E-06 7,493E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 7,241E-06 7,241E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 7,241E-06 6,94E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 7,241E-06 6,662E-04 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 5,000 8,522E-06 7,539E-04 GO:0010498|proteasomal protein catabolic process, ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 1,154E-05 9,826E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,19E-05 9,777E-04 ! nucleus localization GO:0051647 15 9 2,000 1,723E-05 1,366E-03 ! regulation of protein complex assembly GO:0043254 81 54 4,000 1,778E-05 1,363E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 2,32E-05 1,721E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 2,45E-05 1,761E-03 ! phagocytosis, engulfment GO:0006911 20 10 2,000 2,45E-05 1,708E-03 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 4,000 2,983E-05 2,018E-03 ! negative regulation of ligase activity GO:0051352 91 61 4,000 3,234E-05 2,125E-03 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 3,354E-05 2,143E-03 ! filopodium assembly GO:0046847 19 11 2,000 3,354E-05 2,085E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 4,453E-05 2,695E-03 ! microspike assembly GO:0030035 23 12 2,000 4,453E-05 2,626E-03 ! lipid localization GO:0010876 24 13 2,000 5,764E-05 3,314E-03 GO:0019915|lipid storage, ! regulation of exocytosis GO:0017157 17 13 2,000 5,764E-05 3,233E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 5,764E-05 3,156E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 8,597E-05 4,598E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 9,09E-05 4,751E-03 ! energy reserve metabolic process GO:0006112 59 41 3,000 1,049E-04 5,36E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,114E-04 5,569E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 1,114E-04 5,451E-03 ! phosphatidylinositol metabolic process GO:0046488 22 17 2,000 1,347E-04 6,453E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 1,347E-04 6,321E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,347E-04 6,194E-03 ! regulation of ossification GO:0030278 71 46 3,000 1,651E-04 7,448E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 1,902E-04 8,414E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,902E-04 8,255E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 1,902E-04 8,102E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 1,902E-04 7,955E-03 ! positive regulation of osteoblast differentiation GO:0045669 33 20 2,000 2,228E-04 9,151E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 2,427E-04 9,794E-03 ! positive regulation of secretion GO:0051047 71 51 3,000 2,471E-04 9,801E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 2,471E-04 9,635E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 2,588E-04 9,921E-03 ! regulation of cellular component biogenesis GO:0044087 158 96 4,000 2,814E-04 0,01061164 ! regulation of bone remodeling GO:0046850 90 53 3,000 2,869E-04 0,01064479 ! cell projection assembly GO:0030031 76 53 3,000 2,869E-04 0,01047583 ! vasculogenesis GO:0001570 33 22 2,000 2,984E-04 0,01072302 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 2,000 2,984E-04 0,01055805 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of tissue remodeling GO:0034103 91 54 3,000 3,085E-04 0,01075007 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 1,000 3,531E-04 0,01212251 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! positive regulation of glycolysis GO:0045821 11 5 1,000 3,531E-04 0,01194423 ! anagen GO:0042640 6 5 1,000 3,531E-04 0,01177113 ! microvillus organization GO:0032528 7 5 1,000 3,531E-04 0,01160297 GO:0030033|microvillus assembly, ! polyol catabolic process GO:0046174 7 5 1,000 3,531E-04 0,01143955 GO:0019405|alditol catabolic process, ! response to food GO:0032094 5 5 1,000 3,531E-04 0,01128067 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 3,531E-04 0,01112614 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 1,000 3,531E-04 0,01097578 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 3,531E-04 0,01082944 ! regulation of respiratory burst GO:0060263 8 5 1,000 3,531E-04 0,01068695 ! regulation of sensory perception GO:0051931 6 5 1,000 3,531E-04 0,01054815 GO:0051930|regulation of sensory perception of pain, ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 3,531E-04 0,01041292 ! cellular anion homeostasis GO:0030002 6 5 1,000 3,531E-04 0,01028111 GO:0055081|anion homeostasis, ! regulation of lipid metabolic process GO:0019216 84 56 3,000 3,55E-04 0,01020584 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 3,887E-04 0,01103852 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 3,887E-04 0,0109039 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 3,887E-04 0,01077253 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 3,887E-04 0,01064428 ! regulation of osteoblast differentiation GO:0045667 37 24 2,000 3,887E-04 0,01051906 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 4,627E-04 0,01237491 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 4,95E-04 0,0130873 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 5,276E-04 0,01379014 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 5,276E-04 0,0136352 ! regulation of dopamine metabolic process GO:0042053 9 6 1,000 5,276E-04 0,01348369 GO:0042069|regulation of catecholamine metabolic process, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 5,276E-04 0,01333552 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! ER overload response GO:0006983 7 6 1,000 5,276E-04 0,01319057 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 5,276E-04 0,01304874 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 5,276E-04 0,01290992 ! male sex determination GO:0030238 9 6 1,000 5,276E-04 0,01277403 ! positive regulation of cytokine production during immune response GO:0002720 8 6 1,000 5,276E-04 0,01264096 ! positive regulation of B cell differentiation GO:0045579 9 6 1,000 5,276E-04 0,01251064 ! gas homeostasis GO:0033483 11 6 1,000 5,276E-04 0,01238298 ! hair follicle maturation GO:0048820 7 6 1,000 5,276E-04 0,0122579 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 5,276E-04 0,01213532 ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 1,000 5,276E-04 0,01201517 ! midbrain development GO:0030901 6 6 1,000 5,276E-04 0,01189738 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 5,276E-04 0,01178187 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 5,276E-04 0,01166858 ! negative regulation of neuron apoptosis GO:0043524 42 27 2,000 5,545E-04 0,01214615 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 5,575E-04 0,01209644 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 6,183E-04 0,01329134 ! immune response-activating signal transduction GO:0002757 38 28 2,000 6,183E-04 0,01316827 GO:0002764|immune response-regulating signal transduction, ! positive regulation of catabolic process GO:0009896 40 28 2,000 6,183E-04 0,01304746 ! protein oligomerization GO:0051259 100 65 3,000 6,279E-04 0,01312789 ! glycerol-3-phosphate metabolic process GO:0006072 9 7 1,000 7,358E-04 0,0152458 ! regulation of cellular amine metabolic process GO:0033238 10 7 1,000 7,358E-04 0,01510967 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 7,358E-04 0,01497596 ! central nervous system neuron axonogenesis GO:0021955 14 7 1,000 7,358E-04 0,01484459 GO:0021952|central nervous system projection neuron axonogenesis, ! vesicle fusion GO:0006906 15 7 1,000 7,358E-04 0,01471551 ! protein heterooligomerization GO:0051291 10 7 1,000 7,358E-04 0,01458865 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 1,000 7,358E-04 0,01446396 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 1,000 7,358E-04 0,01434139 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 1,000 7,358E-04 0,01422087 ! regulation of fat cell differentiation GO:0045598 9 7 1,000 7,358E-04 0,01410236 ! mast cell activation GO:0045576 9 7 1,000 7,358E-04 0,01398581 ! regulation of interleukin-10 production GO:0032653 11 7 1,000 7,358E-04 0,01387118 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 1,000 7,358E-04 0,0137584 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 7,358E-04 0,01364745 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 7,358E-04 0,01353827 GO:0002714|positive regulation of B cell mediated immunity, ! dopamine biosynthetic process GO:0042416 15 7 1,000 7,358E-04 0,01343082 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 7,358E-04 0,01332507 ! regulation of microtubule-based process GO:0032886 58 30 2,000 7,597E-04 0,01365021 ! positive regulation of immune effector process GO:0002699 40 30 2,000 7,597E-04 0,01354439 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 8,31E-04 0,01470229 ! leukocyte chemotaxis GO:0030595 43 31 2,000 8,374E-04 0,01470245 GO:0060326|cell chemotaxis, ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 9,239E-04 0,01609822 GO:0045937|positive regulation of phosphate metabolic process, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 9,772E-04 0,01689875 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 9,772E-04 0,01677264 ! induction of an organ GO:0001759 11 8 1,000 9,772E-04 0,0166484 ! regulation of embryonic development GO:0045995 16 8 1,000 9,772E-04 0,01652599 ! carbohydrate homeostasis GO:0033500 39 33 2,000 1,008E-03 0,01691619 GO:0042593|glucose homeostasis, ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 1,1E-03 0,0183388 ! glycerol ether metabolic process GO:0006662 44 34 2,000 1,1E-03 0,01820686 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,198E-03 0,01968566 ! glycogen metabolic process GO:0005977 48 35 2,000 1,198E-03 0,01954604 ! protein homooligomerization GO:0051260 52 35 2,000 1,198E-03 0,0194084 ! regulation of developmental growth GO:0048638 13 9 1,000 1,251E-03 0,02012843 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,251E-03 0,01998865 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 1,251E-03 0,0198508 ! regulation of glycolysis GO:0006110 15 9 1,000 1,251E-03 0,01971484 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 1,000 1,251E-03 0,01958072 ! T cell selection GO:0045058 18 9 1,000 1,251E-03 0,01944842 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,251E-03 0,01931789 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,251E-03 0,01918911 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 1,251E-03 0,01906203 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 1,000 1,251E-03 0,01893662 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,251E-03 0,01881285 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 1,251E-03 0,01869069 ! localization within membrane GO:0051668 15 9 1,000 1,251E-03 0,0185701 ! organic ether metabolic process GO:0018904 46 36 2,000 1,302E-03 0,019189 ! tissue remodeling GO:0048771 62 36 2,000 1,302E-03 0,01906678 ! glucan metabolic process GO:0044042 49 36 2,000 1,302E-03 0,01894611 GO:0006073|cellular glucan metabolic process, ! ossification GO:0001503 134 82 3,000 1,5E-03 0,02170375 GO:0060348|bone development, ! phagocytosis GO:0006909 60 38 2,000 1,524E-03 0,02191381 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,558E-03 0,02226005 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 1,558E-03 0,02212264 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,558E-03 0,02198692 ! glucan biosynthetic process GO:0009250 13 10 1,000 1,558E-03 0,02185286 GO:0005978|glycogen biosynthetic process, ! negative regulation of ossification GO:0030279 19 10 1,000 1,558E-03 0,02172041 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,558E-03 0,02158957 ! regulation of B cell differentiation GO:0045577 16 10 1,000 1,558E-03 0,02146029 ! positive regulation of interleukin-6 production GO:0032755 13 10 1,000 1,558E-03 0,02133255 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 1,558E-03 0,02120632 ! positive regulation of acute inflammatory response GO:0002675 14 10 1,000 1,558E-03 0,02108158 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,558E-03 0,02095829 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 1,558E-03 0,02083644 GO:0045168|cell-cell signaling involved in cell fate specification, ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 1,713E-03 0,02277703 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,77E-03 0,02339556 ! skeletal muscle tissue development GO:0007519 123 87 3,000 1,866E-03 0,02452773 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 1,866E-03 0,02438837 ! virus-host interaction GO:0019048 17 11 1,000 1,897E-03 0,0246505 ! cellular carbohydrate catabolic process GO:0044275 13 11 1,000 1,897E-03 0,02451202 ! adult heart development GO:0007512 11 11 1,000 1,897E-03 0,02437508 ! regulation of phagocytosis GO:0050764 14 11 1,000 1,897E-03 0,02423966 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 1,897E-03 0,02410574 ! T cell homeostasis GO:0043029 20 11 1,000 1,897E-03 0,02397329 ! negative regulation of glucose import GO:0046325 14 11 1,000 1,897E-03 0,02384229 GO:0010829|negative regulation of glucose transport, ! regulation of leukocyte mediated immunity GO:0002703 62 41 2,000 1,901E-03 0,02376721 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 2,039E-03 0,02534676 ! regulation of cell shape GO:0008360 78 42 2,000 2,039E-03 0,02521048 ! leukocyte differentiation GO:0002521 143 90 3,000 2,113E-03 0,02599049 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 2,182E-03 0,02669677 ! leukocyte migration GO:0050900 60 43 2,000 2,182E-03 0,02655552 ! monoamine transport GO:0015844 13 12 1,000 2,268E-03 0,02744885 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,268E-03 0,02730514 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 2,268E-03 0,02716293 ! gland morphogenesis GO:0022612 23 12 1,000 2,268E-03 0,02702219 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,268E-03 0,0268829 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 1,000 2,268E-03 0,02674504 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 2,29E-03 0,02686934 ! cell fate commitment GO:0045165 141 92 3,000 2,29E-03 0,02673295 ! regulation of cell projection organization GO:0031344 83 44 2,000 2,332E-03 0,02708536 ! regulation of cytoskeleton organization GO:0051493 154 93 3,000 2,382E-03 0,0275276 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,487E-03 0,0286054 ! response to UV GO:0009411 75 46 2,000 2,649E-03 0,03031704 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,669E-03 0,03039313 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 2,669E-03 0,03024341 ! organelle fusion GO:0048284 28 13 1,000 2,669E-03 0,03009516 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 2,669E-03 0,02994836 ! regulation of cytokine production during immune response GO:0002718 18 13 1,000 2,669E-03 0,02980298 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 2,669E-03 0,029659 ! regulation of acute inflammatory response GO:0002673 19 13 1,000 2,669E-03 0,02951641 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,669E-03 0,02937518 ! regulation of calcium-mediated signaling GO:0050848 18 13 1,000 2,669E-03 0,0292353 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 2,818E-03 0,03071578 ! regulation of protein polymerization GO:0032271 71 47 2,000 2,818E-03 0,0305709 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 2,993E-03 0,03231541 ! regulation of DNA replication GO:0006275 75 48 2,000 2,993E-03 0,0321644 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 2,993E-03 0,0320148 ! neuron maturation GO:0042551 21 14 1,000 3,102E-03 0,03303079 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,102E-03 0,03287858 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 3,102E-03 0,03272776 ! startle response GO:0001964 21 14 1,000 3,102E-03 0,03257832 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 3,102E-03 0,03243023 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 3,102E-03 0,03228349 GO:0031114|regulation of microtubule depolymerization, ! catecholamine biosynthetic process GO:0042423 23 14 1,000 3,102E-03 0,03213807 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 3,102E-03 0,03199395 ! regulation of intracellular transport GO:0032386 78 49 2,000 3,174E-03 0,03259091 ! positive regulation of growth GO:0045927 67 50 2,000 3,362E-03 0,03436779 ! positive regulation of cell migration GO:0030335 92 51 2,000 3,557E-03 0,036197 ! lipid phosphorylation GO:0046834 23 15 1,000 3,565E-03 0,03612391 ! positive regulation of proteolysis GO:0045862 19 15 1,000 3,565E-03 0,03596547 ! regulation of survival gene product expression GO:0045884 20 15 1,000 3,565E-03 0,03580842 ! myoblast differentiation GO:0045445 27 15 1,000 3,565E-03 0,03565273 ! regulation of vasodilation GO:0042312 24 15 1,000 3,565E-03 0,03549839 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 3,565E-03 0,03534538 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 3,565E-03 0,03519368 ! dopamine metabolic process GO:0042417 30 15 1,000 3,565E-03 0,03504328 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 3,565E-03 0,03489416 ! nucleotide-excision repair GO:0006289 64 52 2,000 3,758E-03 0,03662644 ! establishment of organelle localization GO:0051656 85 52 2,000 3,758E-03 0,0364719 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 4,059E-03 0,03922259 ! bone remodeling GO:0046849 24 16 1,000 4,059E-03 0,03905848 ! protein amino acid acetylation GO:0006473 28 16 1,000 4,059E-03 0,03889573 ! fructose metabolic process GO:0006000 20 16 1,000 4,059E-03 0,03873434 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 4,059E-03 0,03857428 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 4,059E-03 0,03841554 ! mesoderm development GO:0007498 76 55 2,000 4,404E-03 0,04151109 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 4,582E-03 0,04301365 ! glycerol metabolic process GO:0006071 20 17 1,000 4,582E-03 0,04283879 ! inactivation of MAPK activity GO:0000188 27 17 1,000 4,582E-03 0,04266536 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 4,582E-03 0,04249332 GO:0002712|regulation of B cell mediated immunity, ! positive regulation of cell motion GO:0051272 99 56 2,000 4,633E-03 0,04279444 ! developmental maturation GO:0021700 75 57 2,000 4,869E-03 0,04479698 ! positive regulation of DNA replication GO:0045740 29 18 1,000 5,135E-03 0,04704933 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 5,135E-03 0,04686262 ! pancreas development GO:0031016 26 18 1,000 5,135E-03 0,04667739 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 5,135E-03 0,04649363 ! glutamine metabolic process GO:0006541 23 18 1,000 5,135E-03 0,0463113 ! central nervous system neuron development GO:0021954 30 18 1,000 5,135E-03 0,04613039 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 5,135E-03 0,0459509 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 5,135E-03 0,04577279 ! somitogenesis GO:0001756 24 18 1,000 5,135E-03 0,04559606 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 5,135E-03 0,0454207 ! activation of JUN kinase activity GO:0007257 23 18 1,000 5,135E-03 0,04524667 ! regulation of glucose import GO:0046324 21 18 1,000 5,135E-03 0,04507397 GO:0010827|regulation of glucose transport, ! activation of MAPK activity GO:0000187 84 59 2,000 5,363E-03 0,04690357 ! lung development GO:0030324 94 59 2,000 5,363E-03 0,0467259 ! myeloid cell differentiation GO:0030099 85 59 2,000 5,363E-03 0,04654958 ! regulation of vesicle-mediated transport GO:0060627 79 60 2,000 5,621E-03 0,04860477 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 5,716E-03 0,04924063 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 5,716E-03 0,04905689 ! sex determination GO:0007530 29 19 1,000 5,716E-03 0,04887453 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 5,716E-03 0,04869351 ! regulation of interleukin-6 production GO:0032675 22 19 1,000 5,716E-03 0,04851383 ! leukotriene biosynthetic process GO:0019370 26 19 1,000 5,716E-03 0,04833547 GO:0043450|alkene biosynthetic process, ! respiratory tube development GO:0030323 99 62 2,000 6,159E-03 0,05189028 ! organelle localization GO:0051640 96 62 2,000 6,159E-03 0,0517009 ! microtubule-based transport GO:0010970 37 20 1,000 6,327E-03 0,05291313 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 6,327E-03 0,05272142 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 6,327E-03 0,05253109 ! positive regulation of B cell activation GO:0050871 31 20 1,000 6,327E-03 0,05234213 ! alditol metabolic process GO:0019400 24 20 1,000 6,327E-03 0,05215452 ! negative regulation of cell size GO:0045792 108 64 2,000 6,727E-03 0,05525591 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 6,727E-03 0,05505927 ! respiratory system development GO:0060541 100 64 2,000 6,727E-03 0,05486402 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 6,965E-03 0,05660829 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 6,965E-03 0,05640896 ! protein amino acid acylation GO:0043543 37 21 1,000 6,965E-03 0,05621104 ! vesicle docking GO:0048278 27 21 1,000 6,965E-03 0,05601449 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 6,965E-03 0,05581932 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 6,965E-03 0,0556255 ! regulation of insulin secretion GO:0050796 26 21 1,000 6,965E-03 0,05543303 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 6,965E-03 0,05524188 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 6,965E-03 0,05505205 ! leukotriene metabolic process GO:0006691 28 21 1,000 6,965E-03 0,05486351 ! regulation of vasoconstriction GO:0019229 31 21 1,000 6,965E-03 0,05467626 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 6,965E-03 0,05449029 ! regulation of bone mineralization GO:0030500 29 21 1,000 6,965E-03 0,05430558 ! defense response to bacterium GO:0042742 73 65 2,000 7,022E-03 0,05456219 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 7,022E-03 0,05437848 ! activation of immune response GO:0002253 83 65 2,000 7,022E-03 0,054196 ! regulation of immune effector process GO:0002697 101 66 2,000 7,325E-03 0,05634317 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 7,632E-03 0,05851178 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 7,632E-03 0,05831738 ! leukocyte adhesion GO:0007159 38 22 1,000 7,632E-03 0,05812428 ! molting cycle process GO:0022404 40 22 1,000 7,632E-03 0,05793245 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 7,632E-03 0,05774188 GO:0010810|regulation of cell-substrate adhesion, ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 7,632E-03 0,05755257 ! regulation of tumor necrosis factor production GO:0032680 28 22 1,000 7,632E-03 0,05736449 ! membrane depolarization GO:0051899 35 22 1,000 7,632E-03 0,05717763 ! leukocyte homeostasis GO:0001776 33 22 1,000 7,632E-03 0,05699199 ! regulation of blood coagulation GO:0030193 34 22 1,000 7,632E-03 0,05680755 ! cellular alkene metabolic process GO:0043449 29 22 1,000 7,632E-03 0,0566243 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 7,632E-03 0,05644223 ! protein tetramerization GO:0051262 39 22 1,000 7,632E-03 0,05626132 ! embryonic pattern specification GO:0009880 31 23 1,000 8,326E-03 0,06118358 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 8,326E-03 0,06098873 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 8,326E-03 0,06079512 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 8,326E-03 0,06060273 ! osteoblast differentiation GO:0001649 40 23 1,000 8,326E-03 0,06041155 ! interaction with host GO:0051701 37 23 1,000 8,326E-03 0,06022158 ! regulation of biomineral formation GO:0070167 31 23 1,000 8,326E-03 0,0600328 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 8,326E-03 0,05984519 ! regulation of catabolic process GO:0009894 106 70 2,000 8,612E-03 0,06170691 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 8,953E-03 0,06395295 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 9,048E-03 0,06442764 ! fat cell differentiation GO:0045444 37 24 1,000 9,048E-03 0,06422879 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 9,048E-03 0,06403117 ! base-excision repair GO:0006284 31 24 1,000 9,048E-03 0,06383475 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 9,048E-03 0,06363954 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of JUN kinase activity GO:0043506 34 24 1,000 9,048E-03 0,06344552 ! regulation of peptidase activity GO:0052547 106 72 2,000 9,303E-03 0,06503283 ! response to hypoxia GO:0001666 132 72 2,000 9,303E-03 0,06483576 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 9,796E-03 0,06807172 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 9,796E-03 0,06786668 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 9,796E-03 0,06766288 ! regulation of peptide secretion GO:0002791 34 25 1,000 9,796E-03 0,0674603 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 9,796E-03 0,06725892 ! response to oxygen levels GO:0070482 137 74 2,000 0,01002439 0,06861932 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 1,000 0,01057152 0,07214985 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01057152 0,07193639 ! post-embryonic development GO:0009791 42 26 1,000 0,01057152 0,07172419 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01057152 0,07151324 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,01057152 0,07130352 ! regulation of coagulation GO:0050818 39 26 1,000 0,01057152 0,07109503 ! regulation of cell morphogenesis GO:0022604 140 76 2,000 0,01077801 0,07227234 ! regulation of protein transport GO:0051223 114 76 2,000 0,01077801 0,07206225 GO:0070201|regulation of establishment of protein localization, ! carbohydrate biosynthetic process GO:0016051 97 77 2,000 0,0111668 0,07444533 ! membrane docking GO:0022406 39 27 1,000 0,01137288 0,0756001 ! inner ear morphogenesis GO:0042472 35 27 1,000 0,01137288 0,07538223 ! catechol metabolic process GO:0009712 43 27 1,000 0,01137288 0,07516561 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 0,01137288 0,07495024 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01137288 0,07473609 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,01156362 0,07577302 ! phenol metabolic process GO:0018958 44 28 1,000 0,01220016 0,07971693 ! icosanoid biosynthetic process GO:0046456 42 28 1,000 0,01220016 0,07949111 ! positive regulation of endocytosis GO:0045807 33 28 1,000 0,01220016 0,07926656 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,01220016 0,07904327 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 0,01220016 0,07882124 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,01220016 0,07860045 ! mesoderm formation GO:0001707 46 28 1,000 0,01220016 0,0783809 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01220016 0,07816256 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01220016 0,07794545 ! BMP signaling pathway GO:0030509 40 28 1,000 0,01220016 0,07772953 ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,01220016 0,07751481 ! placenta development GO:0001890 37 28 1,000 0,01220016 0,07730127 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01220016 0,0770889 ! chromatin assembly GO:0031497 102 80 2,000 0,01238146 0,07802015 GO:0006334|nucleosome assembly, ! positive regulation of cell activation GO:0050867 120 81 2,000 0,01280252 0,08045302 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,01305301 0,08180358 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01305301 0,08158129 ! formation of primary germ layer GO:0001704 48 29 1,000 0,01305301 0,0813602 ! cholesterol transport GO:0030301 46 30 1,000 0,0139311 0,08659875 GO:0015918|sterol transport, ! hindbrain development GO:0030902 45 30 1,000 0,0139311 0,08636533 ! adult locomotory behavior GO:0008344 47 30 1,000 0,0139311 0,08613316 ! response to heat GO:0009408 41 30 1,000 0,0139311 0,08590224 ! protein-DNA complex assembly GO:0065004 107 84 2,000 0,01411458 0,08680091 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 0,01456829 0,08935218 ! rRNA metabolic process GO:0016072 107 85 2,000 0,01456829 0,08911455 GO:0006364|rRNA processing, ! regulation of protein localization GO:0032880 132 85 2,000 0,01456829 0,08887817 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,01456829 0,08864304 ! mammary gland development GO:0030879 57 31 1,000 0,01483412 0,09002234 ! segmentation GO:0035282 41 31 1,000 0,01483412 0,08978544 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,01483412 0,08954978 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 1,000 0,01483412 0,08931536 ! cell fate specification GO:0001708 37 31 1,000 0,01483412 0,08908216 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,01483412 0,08885018 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 0,01503021 0,08979085 ! nucleosome organization GO:0034728 114 87 2,000 0,01550035 0,09235959 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,01576172 0,09367433 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01576172 0,0934329 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,01576172 0,09319271 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01576172 0,09295375 ! interphase GO:0051325 159 88 2,000 0,01597873 0,09399254 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,0167136 0,0980645 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,0167136 0,09781497 ! ear morphogenesis GO:0042471 42 33 1,000 0,0167136 0,09756671 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 0,0167136 0,0973197 ! lipid homeostasis GO:0055088 55 33 1,000 0,0167136 0,09707395 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,0167136 0,09682943 ! regulation of proteolysis GO:0030162 50 33 1,000 0,0167136 0,09658614 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,0167136 0,09634407 ! cytokinesis GO:0000910 52 33 1,000 0,0167136 0,09610321 ! neuron migration GO:0001764 46 34 1,000 0,01768943 0,10146058 ! polyol metabolic process GO:0019751 44 34 1,000 0,01768943 0,10120819 ! positive regulation of immune response GO:0050778 121 92 2,000 0,01797493 0,10258645 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,0184947 0,10529163 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,0186889 0,10613447 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,0186889 0,10587306 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01971168 0,1113928 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 1,000 0,01971168 0,11111978 ! hormone-mediated signaling GO:0009755 49 36 1,000 0,01971168 0,1108481 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,0201039 0,11277796 ! response to light stimulus GO:0009416 153 96 2,000 0,0201039 0,11250356 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,02178802 0,12163214 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,02182598 0,12154906 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02182598 0,12125547 ! mesenchymal cell development GO:0014031 64 38 1,000 0,02182598 0,12096329 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02291689 0,12670393 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,02291689 0,12640009 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,02291689 0,12609769 ! JNK cascade GO:0007254 54 39 1,000 0,02291689 0,12579675 ! developmental growth GO:0048589 62 39 1,000 0,02291689 0,12549723 ! cell growth GO:0016049 61 39 1,000 0,02291689 0,12519914 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,02402988 0,13096856 ! response to calcium ion GO:0051592 58 40 1,000 0,02402988 0,13065894 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,02402988 0,13035078 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,02402988 0,13004407 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,02402988 0,12973881 ! inner ear development GO:0048839 57 40 1,000 0,02402988 0,12943497 ! T cell differentiation GO:0030217 65 40 1,000 0,02402988 0,12913255 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,02516468 0,13491553 ! glucose transport GO:0015758 52 41 1,000 0,02516468 0,13460177 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02516468 0,13428947 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,02516468 0,13397861 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,02516468 0,13366919 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,02632097 0,13948903 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,02632097 0,13916837 ! hexose transport GO:0008645 54 42 1,000 0,02632097 0,13884918 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,02632097 0,13853144 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,02632097 0,13821516 ! positive regulation of binding GO:0051099 59 43 1,000 0,02749848 0,14406947 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,02749848 0,14374204 ! neuromuscular process GO:0050905 79 43 1,000 0,02749848 0,14341609 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,02749848 0,14309162 ! vesicle organization GO:0016050 79 43 1,000 0,02749848 0,14276862 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,0286969 0,14865509 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,0286969 0,14832103 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,0286969 0,14798847 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02967566 0,15269356 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02967566 0,15235273 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02967566 0,15201341 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02967566 0,1516756 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02967566 0,1513393 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02967566 0,15100447 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02967566 0,15067113 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02967566 0,15033926 ! sleep GO:0030431 11 5 0,000 0,02967566 0,15000884 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02967566 0,14967987 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02967566 0,14935235 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02967566 0,14902625 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02967566 0,14870157 ! forebrain regionalization GO:0021871 6 5 0,000 0,02967566 0,14837831 ! tongue development GO:0043586 6 5 0,000 0,02967566 0,14805645 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02967566 0,14773598 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02967566 0,14741689 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02967566 0,14709919 ! cobalt ion transport GO:0006824 9 5 0,000 0,02967566 0,14678284 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02967566 0,14646786 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02967566 0,14615422 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02967566 0,14584193 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02967566 0,14553096 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02967566 0,14522132 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02967566 0,144913 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02967566 0,14460598 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02967566 0,14430026 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02967566 0,14399583 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02967566 0,14369268 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02967566 0,1433908 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02967566 0,14309019 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02967566 0,14279084 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02967566 0,14249274 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02967566 0,14219588 ! malate metabolic process GO:0006108 7 5 0,000 0,02967566 0,14190025 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02967566 0,14160585 ! behavioral response to pain GO:0048266 7 5 0,000 0,02967566 0,14131268 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02967566 0,14102071 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02967566 0,14072994 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02967566 0,14044037 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02967566 0,140152 ! mating behavior GO:0007617 6 5 0,000 0,02967566 0,1398648 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02967566 0,13957878 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02967566 0,13929392 ! rhythmic behavior GO:0007622 12 5 0,000 0,02967566 0,13901023 ! copulation GO:0007620 7 5 0,000 0,02967566 0,13872769 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02967566 0,13844629 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02967566 0,13816604 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02967566 0,13788691 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02967566 0,13760892 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02967566 0,13733204 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02967566 0,13705627 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02967566 0,13678161 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02967566 0,13650804 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02967566 0,13623557 ! response to protozoan GO:0001562 9 5 0,000 0,02967566 0,13596419 ! lymph vessel development GO:0001945 7 5 0,000 0,02967566 0,13569388 ! endochondral ossification GO:0001958 12 5 0,000 0,02967566 0,13542465 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02967566 0,13515648 ! parathyroid gland development GO:0060017 8 5 0,000 0,02967566 0,13488937 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02967566 0,13462332 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02967566 0,13435831 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02967566 0,13409435 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02967566 0,13383142 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02967566 0,13356951 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02967566 0,13330864 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02967566 0,13304878 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02967566 0,13278993 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02967566 0,13253208 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02967566 0,13227524 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02967566 0,13201939 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02967566 0,13176452 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02967566 0,13151064 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02967566 0,13125773 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02967566 0,1310058 ! ovulation GO:0030728 6 5 0,000 0,02967566 0,13075483 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02967566 0,13050482 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,02967566 0,13025577 ! response to pH GO:0009268 9 5 0,000 0,02967566 0,13000766 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02967566 0,1297605 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02967566 0,12951427 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02967566 0,12926898 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02967566 0,12902462 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02967566 0,12878117 ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02967566 0,12853865 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02967566 0,12829703 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02967566 0,12805633 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02967566 0,12781652 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02967566 0,12757761 ! urea metabolic process GO:0019627 6 5 0,000 0,02967566 0,12733959 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02967566 0,12710246 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02967566 0,12686621 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02967566 0,12663084 ! neutrophil activation GO:0042119 5 5 0,000 0,02967566 0,12639634 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02967566 0,1261627 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02967566 0,12592993 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02967566 0,12569801 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02967566 0,12546695 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02967566 0,12523674 ! forebrain neuron development GO:0021884 7 5 0,000 0,02967566 0,12500737 ! melanosome organization GO:0032438 7 5 0,000 0,02967566 0,12477883 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02967566 0,12455114 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02967566 0,12432427 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02967566 0,12409822 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02967566 0,123873 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02967566 0,12364859 ! nucleoside transport GO:0015858 6 5 0,000 0,02967566 0,12342499 ! nucleoside salvage GO:0043174 7 5 0,000 0,02967566 0,12320221 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02967566 0,12298022 ! folic acid transport GO:0015884 9 5 0,000 0,02967566 0,12275903 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02967566 0,12253864 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02967566 0,12231904 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02967566 0,12210022 ! depyrimidination GO:0045008 8 5 0,000 0,02967566 0,12188218 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02967566 0,12166492 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02967566 0,12144844 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02967566 0,12123272 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02967566 0,12101777 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02967566 0,12080358 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02967566 0,12059015 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02967566 0,12037746 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02967566 0,12016553 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02967566 0,11995434 ! monocyte differentiation GO:0030224 8 5 0,000 0,02967566 0,1197439 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02967566 0,11953419 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02967566 0,11932521 ! centrosome duplication GO:0051298 5 5 0,000 0,02967566 0,11911697 ! response to UV-C GO:0010225 6 5 0,000 0,02967566 0,11890945 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02967566 0,11870265 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02967566 0,11849657 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02967566 0,1182912 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02967566 0,11808654 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02967566 0,11788259 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02967566 0,11767935 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02967566 0,1174768 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02967566 0,11727495 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02967566 0,11707379 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02967566 0,11687333 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02967566 0,11667354 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02967566 0,11647444 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02967566 0,11627602 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02967566 0,11607827 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02967566 0,11588119 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02967566 0,11568478 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02967566 0,11548904 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02967566 0,11529396 ! neural tube patterning GO:0021532 6 5 0,000 0,02967566 0,11509953 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02967566 0,11490576 ! histone demethylation GO:0016577 9 5 0,000 0,02967566 0,11471264 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02967566 0,11452017 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02967566 0,11432835 ! enteric nervous system development GO:0048484 8 5 0,000 0,02967566 0,11413716 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02967566 0,11394661 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02967566 0,1137567 ! transcription termination GO:0006353 8 5 0,000 0,02967566 0,11356742 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02967566 0,11337877 ! plasminogen activation GO:0031639 5 5 0,000 0,02967566 0,11319075 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02967566 0,11300335 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02967566 0,11281657 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02967566 0,1126304 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02967566 0,11244485 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02967566 0,1122599 ! apical protein localization GO:0045176 6 5 0,000 0,02967566 0,11207557 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02967566 0,11189184 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02967566 0,11170871 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02967566 0,11152618 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02967566 0,11134424 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02967566 0,1111629 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02967566 0,11098215 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02967566 0,11080198 ! glial cell migration GO:0008347 10 5 0,000 0,02967566 0,1106224 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02967566 0,1104434 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02967566 0,11026498 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02967566 0,11008713 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02967566 0,10990986 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02967566 0,10973315 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02967566 0,10955702 ! neural plate development GO:0001840 6 5 0,000 0,02967566 0,10938145 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02967566 0,10920644 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02967566 0,10903198 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02967566 0,10885809 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02967566 0,10868475 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02967566 0,10851196 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02967566 0,10833972 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02967566 0,10816802 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02967566 0,10799687 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02967566 0,10782626 ! spindle assembly GO:0051225 5 5 0,000 0,02967566 0,10765619 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02967566 0,10748665 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02967566 0,10731764 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02967566 0,10714917 ! organ regeneration GO:0031100 7 5 0,000 0,02967566 0,10698123 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02967566 0,10681381 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02967566 0,10664691 GO:0006577|betaine metabolic process, ! positive regulation of defense response GO:0031349 59 45 1,000 0,02991594 0,10734269 ! cell maturation GO:0048469 60 45 1,000 0,02991594 0,10717549 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,03115533 0,11144207 ! cell redox homeostasis GO:0045454 63 46 1,000 0,03115533 0,11126902 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,03115533 0,11109651 ! histone modification GO:0016570 68 46 1,000 0,03115533 0,11092454 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,03115533 0,11075309 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03241477 0,11505242 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,03241477 0,11487515 ! glutamine family amino acid metabolic process GO:0009064 59 47 1,000 0,03241477 0,11469842 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,03241477 0,11452223 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of muscle contraction GO:0006937 69 48 1,000 0,03369399 0,11885917 ! response to temperature stimulus GO:0009266 62 48 1,000 0,03369399 0,11867715 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,03369399 0,11849569 ! gastrulation GO:0007369 73 48 1,000 0,03369399 0,11831478 ! heart morphogenesis GO:0003007 65 48 1,000 0,03369399 0,11813442 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,03369399 0,11795461 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 1,000 0,03369399 0,11777535 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,03369399 0,11759663 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,03369399 0,11741845 ! RNA elongation GO:0006354 62 49 1,000 0,03499271 0,12175981 ! germ cell development GO:0007281 68 49 1,000 0,03499271 0,12157588 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,03499271 0,12139251 ! maintenance of location GO:0051235 84 49 1,000 0,03499271 0,12120969 ! tRNA transcription GO:0009304 11 6 0,000 0,03550527 0,12280018 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03550527 0,1226158 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03550527 0,12243196 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03550527 0,12224868 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03550527 0,12206595 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03550527 0,12188376 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03550527 0,12170212 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03550527 0,12152101 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03550527 0,12134045 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03550527 0,12116042 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03550527 0,12098092 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03550527 0,12080195 ! prostate gland development GO:0030850 9 6 0,000 0,03550527 0,12062352 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03550527 0,1204456 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03550527 0,12026822 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03550527 0,12009135 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03550527 0,11991501 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03550527 0,11973918 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03550527 0,11956387 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03550527 0,11938906 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03550527 0,11921477 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03550527 0,11904099 ! neuron adhesion GO:0007158 9 6 0,000 0,03550527 0,11886771 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03550527 0,11869494 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03550527 0,11852267 ! signal peptide processing GO:0006465 8 6 0,000 0,03550527 0,1183509 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03550527 0,11817962 ! mRNA stabilization GO:0048255 15 6 0,000 0,03550527 0,11800884 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03550527 0,11783856 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03550527 0,11766876 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03550527 0,11749945 ! opsonization GO:0008228 8 6 0,000 0,03550527 0,11733063 ! erythrocyte maturation GO:0043249 6 6 0,000 0,03550527 0,1171623 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03550527 0,11699444 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03550527 0,11682707 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03550527 0,11666017 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03550527 0,11649375 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03550527 0,11632781 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03550527 0,11616233 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03550527 0,11599733 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03550527 0,11583279 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03550527 0,11566873 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03550527 0,11550512 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03550527 0,11534198 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03550527 0,11517929 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03550527 0,11501707 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03550527 0,1148553 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03550527 0,11469399 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03550527 0,11453313 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03550527 0,11437272 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03550527 0,11421276 ! thymic T cell selection GO:0045061 12 6 0,000 0,03550527 0,11405324 ! protein lipoylation GO:0009249 10 6 0,000 0,03550527 0,11389417 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03550527 0,11373554 ! pigment granule organization GO:0048753 11 6 0,000 0,03550527 0,11357736 ! drug transport GO:0015893 6 6 0,000 0,03550527 0,11341961 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03550527 0,1132623 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03550527 0,11310543 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03550527 0,11294899 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03550527 0,11279298 ! histidine metabolic process GO:0006547 6 6 0,000 0,03550527 0,11263741 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03550527 0,11248226 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03550527 0,11232754 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,03550527 0,11217324 ! adenohypophysis development GO:0021984 10 6 0,000 0,03550527 0,11201937 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03550527 0,11186592 ! hyperosmotic response GO:0006972 8 6 0,000 0,03550527 0,11171289 ! microtubule nucleation GO:0007020 10 6 0,000 0,03550527 0,11156027 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03550527 0,11140808 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03550527 0,11125629 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03550527 0,11110493 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03550527 0,11095397 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03550527 0,11080342 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03550527 0,11065328 ! response to dietary excess GO:0002021 7 6 0,000 0,03550527 0,11050355 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03550527 0,11035422 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03550527 0,11020529 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03550527 0,11005677 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03550527 0,10990864 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03550527 0,10976091 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03550527 0,10961358 ! neuron apoptosis GO:0051402 8 6 0,000 0,03550527 0,10946665 ! organic alcohol transport GO:0015850 9 6 0,000 0,03550527 0,10932011 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03550527 0,10917396 ! carnitine transport GO:0015879 8 6 0,000 0,03550527 0,1090282 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03550527 0,10888283 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03550527 0,10873784 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03550527 0,10859324 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03550527 0,10844903 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03550527 0,1083052 ! parturition GO:0007567 12 6 0,000 0,03550527 0,10816175 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03550527 0,10801868 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03550527 0,10787598 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03550527 0,10773367 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03550527 0,10759173 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03550527 0,10745016 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03550527 0,10730896 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03550527 0,10716814 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03550527 0,10702768 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03550527 0,10688759 ! astrocyte development GO:0014002 14 6 0,000 0,03550527 0,10674787 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03550527 0,10660851 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03550527 0,10646952 ! interaction with symbiont GO:0051702 8 6 0,000 0,03550527 0,10633089 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03550527 0,10619261 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03550527 0,1060547 ! eating behavior GO:0042755 6 6 0,000 0,03550527 0,10591715 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03550527 0,10577995 ! response to copper ion GO:0046688 9 6 0,000 0,03550527 0,1056431 ! DNA topological change GO:0006265 8 6 0,000 0,03550527 0,10550662 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03550527 0,10537048 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03550527 0,10523469 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03550527 0,10509925 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03550527 0,10496416 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03550527 0,10482942 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03550527 0,10469503 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03550527 0,10456097 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03550527 0,10442726 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03550527 0,1042939 ! Schwann cell development GO:0014044 14 6 0,000 0,03550527 0,10416087 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03550527 0,10402818 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03550527 0,10389583 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03550527 0,10376381 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03550527 0,10363213 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03550527 0,10350079 ! histone ubiquitination GO:0016574 7 6 0,000 0,03550527 0,10336977 ! regulation of meiosis GO:0040020 10 6 0,000 0,03550527 0,10323909 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03550527 0,10310874 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03550527 0,10297871 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03550527 0,10284902 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03550527 0,10271965 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03550527 0,1025906 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03550527 0,10246188 ! receptor internalization GO:0031623 9 6 0,000 0,03550527 0,10233348 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03550527 0,10220541 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03550527 0,10207765 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03550527 0,10195021 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03550527 0,10182309 ! protein deubiquitination GO:0016579 8 6 0,000 0,03550527 0,10169629 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03550527 0,1015698 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,03550527 0,10144363 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03550527 0,10131777 ! axonal fasciculation GO:0007413 9 6 0,000 0,03550527 0,10119222 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03550527 0,10106698 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03550527 0,10094205 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03550527 0,10081743 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03550527 0,10069312 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03550527 0,10056911 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03550527 0,10044541 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03550527 0,10032201 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03550527 0,10019892 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03550527 0,10007613 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03550527 0,09995364 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03550527 0,09983144 ! adult feeding behavior GO:0008343 6 6 0,000 0,03550527 0,09970955 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03550527 0,09958795 ! blastocyst growth GO:0001832 15 6 0,000 0,03550527 0,09946665 ! pigment granule transport GO:0051904 12 6 0,000 0,03550527 0,09934564 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03550527 0,09922493 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03550527 0,09910451 ! catecholamine transport GO:0051937 7 6 0,000 0,03550527 0,09898439 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03550527 0,09886455 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03550527 0,09874501 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03550527 0,09862575 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03550527 0,09850678 ! protein prenylation GO:0018342 10 6 0,000 0,03550527 0,0983881 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03550527 0,0982697 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,03550527 0,09815159 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03550527 0,09803376 ! regulation of actin filament length GO:0030832 72 50 1,000 0,03631065 0,1001373 ! ear development GO:0043583 72 50 1,000 0,03631065 0,10001737 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,03631065 0,09989773 ! membrane fusion GO:0006944 80 50 1,000 0,03631065 0,09977838 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,03631065 0,09965931 ! lipid modification GO:0030258 73 50 1,000 0,03631065 0,09954053 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,03631065 0,09942203 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,03631065 0,09930381 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03764755 0,10283772 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,03764755 0,10271573 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,03764755 0,10259403 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,03764755 0,10247262 ! adult behavior GO:0030534 80 51 1,000 0,03764755 0,10235149 ! regulation of cellular component size GO:0032535 74 52 1,000 0,03900312 0,10591167 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03900312 0,10578677 ! single fertilization GO:0007338 59 53 1,000 0,04037711 0,1093844 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04130019 0,11175344 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04130019 0,11162212 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04130019 0,11149111 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04130019 0,11136041 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04130019 0,11123001 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04130019 0,11109991 GO:0070193|synaptonemal complex organization, ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04130019 0,11097012 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04130019 0,11084064 ! reproductive behavior GO:0019098 12 7 0,000 0,04130019 0,11071145 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04130019 0,11058257 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04130019 0,11045398 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,04130019 0,1103257 ! oligopeptide transport GO:0006857 11 7 0,000 0,04130019 0,11019771 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04130019 0,11007002 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04130019 0,10994262 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,04130019 0,10981552 ! pericardium development GO:0060039 8 7 0,000 0,04130019 0,10968871 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04130019 0,1095622 ! fibril organization GO:0043206 13 7 0,000 0,04130019 0,10943597 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04130019 0,10931004 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04130019 0,1091844 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,04130019 0,10905904 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04130019 0,10893397 ! lipoprotein transport GO:0042953 9 7 0,000 0,04130019 0,10880919 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04130019 0,1086847 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04130019 0,10856049 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04130019 0,10843656 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04130019 0,10831291 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04130019 0,10818955 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04130019 0,10806647 ! chemosensory behavior GO:0007635 9 7 0,000 0,04130019 0,10794367 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04130019 0,10782114 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04130019 0,1076989 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04130019 0,10757693 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04130019 0,10745523 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04130019 0,10733381 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04130019 0,10721267 ! reflex GO:0060004 12 7 0,000 0,04130019 0,1070918 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04130019 0,1069712 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04130019 0,10685087 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04130019 0,10673082 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04130019 0,10661103 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04130019 0,10649151 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04130019 0,10637226 ! spinal cord patterning GO:0021511 7 7 0,000 0,04130019 0,10625327 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04130019 0,10613455 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04130019 0,1060161 ! adrenal gland development GO:0030325 17 7 0,000 0,04130019 0,10589791 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04130019 0,10577998 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04130019 0,10566232 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04130019 0,10554492 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04130019 0,10542778 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04130019 0,10531089 ! endosome organization GO:0007032 10 7 0,000 0,04130019 0,10519427 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04130019 0,10507791 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04130019 0,1049618 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04130019 0,10484594 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04130019 0,10473035 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04130019 0,10461501 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04130019 0,10449992 ! galactose metabolic process GO:0006012 10 7 0,000 0,04130019 0,10438508 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04130019 0,1042705 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04130019 0,10415617 ! organ growth GO:0035265 11 7 0,000 0,04130019 0,10404209 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04130019 0,10392826 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04130019 0,10381467 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04130019 0,10370134 ! retinol metabolic process GO:0042572 9 7 0,000 0,04130019 0,10358825 ! behavioral fear response GO:0001662 13 7 0,000 0,04130019 0,10347541 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04130019 0,10336281 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04130019 0,10325046 ! rRNA modification GO:0000154 12 7 0,000 0,04130019 0,10313836 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04130019 0,10302649 ! response to UV-B GO:0010224 11 7 0,000 0,04130019 0,10291487 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04130019 0,10280349 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04130019 0,10269235 ! intermediate filament organization GO:0045109 11 7 0,000 0,04130019 0,10258145 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04130019 0,10247079 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04130019 0,10236037 ! fibrinolysis GO:0042730 9 7 0,000 0,04130019 0,10225019 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04130019 0,10214024 ! B cell lineage commitment GO:0002326 17 7 0,000 0,04130019 0,10203053 ! response to tropane GO:0014073 13 7 0,000 0,04130019 0,10192106 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! melanosome localization GO:0032400 10 7 0,000 0,04130019 0,10181182 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04130019 0,10170281 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04130019 0,10159404 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04130019 0,1014855 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04130019 0,10137719 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04130019 0,10126911 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04130019 0,10116126 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04130019 0,10105364 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04130019 0,10094626 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04130019 0,10083909 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04130019 0,10073216 ! T cell lineage commitment GO:0002360 12 7 0,000 0,04130019 0,10062545 ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04130019 0,10051897 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04130019 0,10041271 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04130019 0,10030668 ! response to tumor cell GO:0002347 12 7 0,000 0,04130019 0,10020087 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04130019 0,10009529 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04130019 0,09998992 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04130019 0,09988478 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04130019 0,09977986 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04130019 0,09967516 ! diuresis GO:0030146 12 7 0,000 0,04130019 0,09957068 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04130019 0,09946641 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04130019 0,09936237 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04130019 0,09925854 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04130019 0,09915493 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04130019 0,09905154 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04130019 0,09894836 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04130019 0,0988454 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04130019 0,09874265 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04130019 0,09864011 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04130019 0,09853779 ! lymph node development GO:0048535 9 7 0,000 0,04130019 0,09843567 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04130019 0,09833377 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04130019 0,09823208 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04130019 0,09813061 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04130019 0,09802934 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04130019 0,09792827 ! ATP catabolic process GO:0006200 10 7 0,000 0,04130019 0,09782742 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04130019 0,09772678 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04130019 0,09762634 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04130019 0,0975261 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04130019 0,09742608 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04130019 0,09732626 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04130019 0,09722664 ! muscle adaptation GO:0043500 12 7 0,000 0,04130019 0,09712723 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04130019 0,09702801 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04130019 0,09692901 ! retina homeostasis GO:0001895 9 7 0,000 0,04130019 0,0968302 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04130019 0,09673159 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04130019 0,09663319 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04130019 0,09653499 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04130019 0,09643698 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04130019 0,09633917 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04130019 0,09624157 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04176924 0,09723609 ! DNA catabolic process GO:0006308 67 54 1,000 0,04176924 0,09713777 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04176924 0,09703966 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,0446069 0,10352762 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,04605191 0,10677357 ! carbohydrate transport GO:0008643 74 57 1,000 0,04605191 0,10666605 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04706061 0,10889277 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04706061 0,10878333 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,04706061 0,10867411 ! axon extension GO:0048675 11 8 0,000 0,04706061 0,10856511 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04706061 0,10845632 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04706061 0,10834776 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04706061 0,10823941 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04706061 0,10813128 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04706061 0,10802336 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04706061 0,10791566 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,04706061 0,10780818 ! phosphate transport GO:0006817 10 8 0,000 0,04706061 0,10770091 ! N-glycan processing GO:0006491 12 8 0,000 0,04706061 0,10759385 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04706061 0,107487 ! UTP metabolic process GO:0046051 8 8 0,000 0,04706061 0,10738037 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04706061 0,10727395 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04706061 0,10716773 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,04706061 0,10706173 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04706061 0,10695594 ! succinate metabolic process GO:0006105 14 8 0,000 0,04706061 0,10685036 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04706061 0,10674498 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04706061 0,10663981 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,04706061 0,10653485 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04706061 0,1064301 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,04706061 0,10632555 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04706061 0,10622121 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04706061 0,10611707 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04706061 0,10601313 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04706061 0,1059094 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04706061 0,10580588 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04706061 0,10570255 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04706061 0,10559943 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04706061 0,1054965 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04706061 0,10539378 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04706061 0,10529126 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04706061 0,10518893 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04706061 0,10508681 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04706061 0,10498488 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04706061 0,10488315 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04706061 0,10478162 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04706061 0,10468028 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04706061 0,10457914 ! melanin metabolic process GO:0006582 12 8 0,000 0,04706061 0,1044782 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04706061 0,10437745 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04706061 0,10427689 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,04706061 0,10417653 ! macrophage activation GO:0042116 12 8 0,000 0,04706061 0,10407636 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04706061 0,10397638 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04706061 0,10387659 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04706061 0,103777 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04706061 0,1036776 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04706061 0,10357838 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04706061 0,10347936 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04706061 0,10338053 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04706061 0,10328188 ! ruffle organization GO:0031529 11 8 0,000 0,04706061 0,10318342 ! osteoblast development GO:0002076 13 8 0,000 0,04706061 0,10308515 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04706061 0,10298707 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04706061 0,10288917 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04706061 0,10279146 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04706061 0,10269394 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04706061 0,1025966 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04706061 0,10249944 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04706061 0,10240247 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04706061 0,10230568 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04706061 0,10220908 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,04706061 0,10211265 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,04706061 0,10201641 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04706061 0,10192035 ! segment specification GO:0007379 10 8 0,000 0,04706061 0,10182447 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,04706061 0,10172877 ! cellular extravasation GO:0045123 11 8 0,000 0,04706061 0,10163325 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04706061 0,10153791 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04706061 0,10144275 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04706061 0,10134776 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,04706061 0,10125296 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04706061 0,10115833 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04706061 0,10106388 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04706061 0,1009696 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,04706061 0,1008755 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04706061 0,10078157 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04706061 0,10068782 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04706061 0,10059425 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04706061 0,10050085 ! icosanoid secretion GO:0032309 12 8 0,000 0,04706061 0,10040762 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04706061 0,10031456 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04706061 0,10022168 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04706061 0,10012896 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04706061 0,10003642 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04706061 0,09994405 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04706061 0,09985185 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04706061 0,09975983 ! sterol catabolic process GO:0016127 9 8 0,000 0,04706061 0,09966797 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04706061 0,09957627 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04706061 0,09948475 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04706061 0,0993934 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04706061 0,09930221 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04706061 0,09921119 ! prophase GO:0051324 11 8 0,000 0,04706061 0,09912034 ! S phase GO:0051320 8 8 0,000 0,04706061 0,09902965 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04706061 0,09893913 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,04706061 0,09884878 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04706061 0,09875859 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04706061 0,09866856 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04706061 0,0985787 ! hormone catabolic process GO:0042447 13 8 0,000 0,04706061 0,098489 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04706061 0,09839946 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04706061 0,09831009 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04706061 0,09822088 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04706061 0,09813183 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04706061 0,09804294 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,04706061 0,09795422 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04706061 0,09786565 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04706061 0,09777725 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04706061 0,097689 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04706061 0,09760091 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04706061 0,09751298 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04706061 0,09742521 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04706061 0,0973376 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04706061 0,09725014 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,04706061 0,09716285 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,04751402 0,09801099 ! viral reproductive process GO:0022415 87 58 1,000 0,04751402 0,09792316 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,04751402 0,0978355 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,04751402 0,09774799 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,05048857 0,10377454 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,05048857 0,10368189 GO:0035113|embryonic appendage morphogenesis, ! fertilization GO:0009566 68 60 1,000 0,05048857 0,1035894 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,05048857 0,10349707 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,05200051 0,10650148 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,05200051 0,10640673 ! fatty acid biosynthetic process GO:0006633 92 61 1,000 0,05200051 0,10631215 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,05200051 0,10621773 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05278676 0,10772808 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05278676 0,10763257 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05278676 0,10753724 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05278676 0,10744207 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05278676 0,10734707 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05278676 0,10725224 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05278676 0,10715758 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05278676 0,10706309 ! GTP metabolic process GO:0046039 9 9 0,000 0,05278676 0,10696876 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05278676 0,1068746 ! social behavior GO:0035176 14 9 0,000 0,05278676 0,1067806 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05278676 0,10668677 ! artery development GO:0060840 19 9 0,000 0,05278676 0,1065931 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05278676 0,1064996 ! response to pain GO:0048265 16 9 0,000 0,05278676 0,10640626 ! protein complex disassembly GO:0043241 17 9 0,000 0,05278676 0,10631308 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05278676 0,10622007 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05278676 0,10612722 ! lung alveolus development GO:0048286 17 9 0,000 0,05278676 0,10603453 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05278676 0,10594201 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05278676 0,10584964 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05278676 0,10575744 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05278676 0,1056654 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05278676 0,10557351 ! protein targeting to ER GO:0045047 19 9 0,000 0,05278676 0,10548179 ! endoderm development GO:0007492 12 9 0,000 0,05278676 0,10539023 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05278676 0,10529882 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05278676 0,10520757 ! arginine catabolic process GO:0006527 10 9 0,000 0,05278676 0,10511649 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05278676 0,10502555 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05278676 0,10493478 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05278676 0,10484416 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05278676 0,1047537 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05278676 0,1046634 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05278676 0,10457325 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05278676 0,10448325 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05278676 0,10439341 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05278676 0,10430373 ! mannose metabolic process GO:0006013 9 9 0,000 0,05278676 0,1042142 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05278676 0,10412482 ! receptor clustering GO:0043113 15 9 0,000 0,05278676 0,1040356 ! epithelial cell development GO:0002064 10 9 0,000 0,05278676 0,10394653 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05278676 0,10385761 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05278676 0,10376884 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05278676 0,10368022 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05278676 0,10359176 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05278676 0,10350345 ! motor axon guidance GO:0008045 14 9 0,000 0,05278676 0,10341528 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05278676 0,10332727 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05278676 0,10323941 ! DNA ligation GO:0006266 14 9 0,000 0,05278676 0,10315169 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05278676 0,10306413 ! response to amine stimulus GO:0014075 13 9 0,000 0,05278676 0,10297671 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05278676 0,10288944 ! erythrocyte development GO:0048821 11 9 0,000 0,05278676 0,10280232 ! renal water homeostasis GO:0003091 14 9 0,000 0,05278676 0,10271535 ! postreplication repair GO:0006301 11 9 0,000 0,05278676 0,10262852 ! mRNA cleavage GO:0006379 13 9 0,000 0,05278676 0,10254184 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05278676 0,10245531 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05278676 0,10236892 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05278676 0,10228268 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05278676 0,10219658 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05278676 0,10211063 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,05278676 0,10202482 ! acid secretion GO:0046717 14 9 0,000 0,05278676 0,10193916 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05278676 0,10185364 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05278676 0,10176827 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05278676 0,10168303 ! purine base metabolic process GO:0006144 18 9 0,000 0,05278676 0,10159794 ! oocyte differentiation GO:0009994 12 9 0,000 0,05278676 0,10151299 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,05278676 0,10142819 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05278676 0,10134352 ! spleen development GO:0048536 15 9 0,000 0,05278676 0,101259 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,05278676 0,10117462 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05278676 0,10109038 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05278676 0,10100627 ! detection of calcium ion GO:0005513 13 9 0,000 0,05278676 0,10092231 ! blastocyst formation GO:0001825 12 9 0,000 0,05278676 0,10083849 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05278676 0,10075481 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05278676 0,10067126 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05278676 0,10058786 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05278676 0,10050459 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05278676 0,10042146 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05278676 0,10033846 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05278676 0,10025561 ! prepulse inhibition GO:0060134 14 9 0,000 0,05278676 0,10017289 ! embryonic placenta development GO:0001892 12 9 0,000 0,05278676 0,10009031 ! insulin secretion GO:0030073 17 9 0,000 0,05278676 0,10000786 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05278676 0,09992555 ! response to nicotine GO:0035094 16 9 0,000 0,05278676 0,09984337 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05278676 0,09976133 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05278676 0,09967943 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,05352855 0,10099727 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,05352855 0,10091448 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,05507246 0,1037401 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,05507246 0,10365521 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,05507246 0,10357045 ! viral reproduction GO:0016032 92 63 1,000 0,05507246 0,10348584 ! regulation of lipase activity GO:0060191 109 63 1,000 0,05507246 0,10340136 ! appendage morphogenesis GO:0035107 93 64 1,000 0,056632 0,10624274 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,056632 0,10615615 ! adaptive immune response GO:0002250 94 64 1,000 0,056632 0,10606971 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of caspase activity GO:0043281 97 65 1,000 0,05820692 0,10893078 ! appendage development GO:0048736 94 65 1,000 0,05820692 0,10884222 GO:0060173|limb development, ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,05820692 0,1087538 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05847882 0,10917312 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05847882 0,10908458 ! neuron fate specification GO:0048665 11 10 0,000 0,05847882 0,10899618 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05847882 0,10890792 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05847882 0,10881981 ! thyroid gland development GO:0030878 19 10 0,000 0,05847882 0,10873184 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,05847882 0,10864401 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05847882 0,10855632 ! synapsis GO:0007129 13 10 0,000 0,05847882 0,10846878 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05847882 0,10838137 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05847882 0,10829411 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05847882 0,10820699 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,05847882 0,10812 ! sulfate transport GO:0008272 12 10 0,000 0,05847882 0,10803316 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05847882 0,10794645 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,05847882 0,10785989 ! phospholipid efflux GO:0033700 16 10 0,000 0,05847882 0,10777346 ! hippocampus development GO:0021766 19 10 0,000 0,05847882 0,10768718 ! blood vessel remodeling GO:0001974 21 10 0,000 0,05847882 0,10760103 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05847882 0,10751501 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05847882 0,10742914 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05847882 0,1073434 ! pathogenesis GO:0009405 13 10 0,000 0,05847882 0,1072578 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05847882 0,10717234 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05847882 0,10708701 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05847882 0,10700182 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05847882 0,10691676 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,05847882 0,10683184 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05847882 0,10674705 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05847882 0,1066624 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05847882 0,10657788 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05847882 0,10649349 ! response to X-ray GO:0010165 16 10 0,000 0,05847882 0,10640924 ! B cell proliferation GO:0042100 14 10 0,000 0,05847882 0,10632512 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05847882 0,10624114 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05847882 0,10615729 ! forebrain cell migration GO:0021885 17 10 0,000 0,05847882 0,10607357 ! lipid digestion GO:0044241 15 10 0,000 0,05847882 0,10598998 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05847882 0,10590652 ! UV protection GO:0009650 14 10 0,000 0,05847882 0,1058232 ! entry into host cell GO:0030260 20 10 0,000 0,05847882 0,10574 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,05847882 0,10565694 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05847882 0,10557401 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05847882 0,1054912 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,05847882 0,10540853 ! regulation of bone resorption GO:0045124 24 10 0,000 0,05847882 0,10532598 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05847882 0,10524357 ! regulation of organ growth GO:0046620 11 10 0,000 0,05847882 0,10516128 ! response to dsRNA GO:0043331 18 10 0,000 0,05847882 0,10507913 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05847882 0,1049971 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05847882 0,1049152 ! embryonic axis specification GO:0000578 12 10 0,000 0,05847882 0,10483342 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05847882 0,10475178 ! cranial nerve development GO:0021545 12 10 0,000 0,05847882 0,10467026 ! fucose catabolic process GO:0019317 16 10 0,000 0,05847882 0,10458887 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,05847882 0,1045076 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05847882 0,10442646 ! protein sumoylation GO:0016925 12 10 0,000 0,05847882 0,10434545 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05847882 0,10426456 ! zymogen activation GO:0031638 14 10 0,000 0,05847882 0,1041838 ! salivary gland development GO:0007431 22 10 0,000 0,05847882 0,10410316 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05847882 0,10402265 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05847882 0,10394226 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05847882 0,10386199 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,05847882 0,10378185 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05847882 0,10370184 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05847882 0,10362194 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05847882 0,10354217 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05847882 0,10346253 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05847882 0,103383 ! detection of bacterium GO:0016045 10 10 0,000 0,05847882 0,1033036 ! embryonic gut development GO:0048566 11 10 0,000 0,05847882 0,10322432 ! activation of innate immune response GO:0002218 10 10 0,000 0,05847882 0,10314516 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05847882 0,10306612 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05847882 0,1029872 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05847882 0,1029084 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05847882 0,10282973 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05847882 0,10275117 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05847882 0,10267273 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,059797 0,10490701 ! antigen processing and presentation GO:0019882 96 66 1,000 0,059797 0,10482705 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,06140198 0,10755869 ! inorganic anion transport GO:0015698 93 68 1,000 0,06302165 0,11031187 ! rRNA transcription GO:0009303 17 11 0,000 0,064137 0,11217878 ! respiratory burst GO:0045730 14 11 0,000 0,064137 0,11209354 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,064137 0,11200843 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,064137 0,11192344 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,064137 0,11183859 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,064137 0,11175386 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,064137 0,11166926 ! RNA polyadenylation GO:0043631 19 11 0,000 0,064137 0,11158479 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,064137 0,11150045 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,064137 0,11141624 ! mating GO:0007618 14 11 0,000 0,064137 0,11133215 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,064137 0,11124819 ! T cell proliferation GO:0042098 20 11 0,000 0,064137 0,11116435 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,064137 0,11108065 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,064137 0,11099706 ! bone resorption GO:0045453 16 11 0,000 0,064137 0,11091361 ! regulated secretory pathway GO:0045055 14 11 0,000 0,064137 0,11083028 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,064137 0,11074707 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,064137 0,11066399 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,064137 0,11058103 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,064137 0,1104982 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,064137 0,11041549 ! syncytium formation GO:0006949 15 11 0,000 0,064137 0,11033291 ! plasma membrane organization GO:0007009 18 11 0,000 0,064137 0,11025045 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,064137 0,11016811 ! focal adhesion formation GO:0048041 24 11 0,000 0,064137 0,11008589 ! mitotic spindle organization GO:0007052 15 11 0,000 0,064137 0,1100038 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,064137 0,10992183 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,064137 0,10983998 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,064137 0,10975826 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,064137 0,10967665 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,064137 0,10959517 ! temperature homeostasis GO:0001659 16 11 0,000 0,064137 0,10951381 ! L-glutamate transport GO:0015813 16 11 0,000 0,064137 0,10943256 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,064137 0,10935144 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,064137 0,10927044 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,064137 0,10918956 ! stem cell development GO:0048864 29 11 0,000 0,064137 0,1091088 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,064137 0,10902816 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,064137 0,10894763 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,064137 0,10886723 ! vasoconstriction GO:0042310 15 11 0,000 0,064137 0,10878694 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,064137 0,10870678 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,064137 0,10862673 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,064137 0,1085468 ! ribosome assembly GO:0042255 13 11 0,000 0,064137 0,10846698 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,064137 0,10838729 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,064137 0,10830771 ! chromatin silencing GO:0006342 19 11 0,000 0,064137 0,10822824 ! nucleosome positioning GO:0016584 13 11 0,000 0,064137 0,1081489 ! regulation of isotype switching GO:0045191 19 11 0,000 0,064137 0,10806967 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,064137 0,10799055 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,064137 0,10791156 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,064137 0,10783267 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,064137 0,10775391 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,064137 0,10767525 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,064137 0,10759672 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,064137 0,10751829 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,064137 0,10743998 ! male genitalia development GO:0030539 13 11 0,000 0,064137 0,10736179 ! cholesterol efflux GO:0033344 19 11 0,000 0,064137 0,10728371 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,064137 0,10720574 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,064137 0,10712788 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,064137 0,10705014 ! germ cell migration GO:0008354 18 11 0,000 0,064137 0,10697251 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,064137 0,106895 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,064137 0,10681759 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,064137 0,1067403 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,064137 0,10666312 ! lysogeny GO:0030069 18 11 0,000 0,064137 0,10658605 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,064137 0,1065091 ! acrosome reaction GO:0007340 13 11 0,000 0,064137 0,10643225 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,064137 0,10635551 ! response to metal ion GO:0010038 103 70 1,000 0,06630411 0,10986993 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,06630411 0,10979083 ! amine transport GO:0015837 101 70 1,000 0,06630411 0,10971184 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,06630411 0,10963297 ! muscle cell differentiation GO:0042692 104 71 1,000 0,06796645 0,11230089 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,06796645 0,11222027 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,06796645 0,11213977 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,06964256 0,11482286 ! lactation GO:0007595 20 12 0,000 0,0697615 0,11493656 ! reproductive cellular process GO:0048610 14 12 0,000 0,0697615 0,11485429 ! tRNA modification GO:0006400 14 12 0,000 0,0697615 0,11477213 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,0697615 0,1146901 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,0697615 0,11460817 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,0697615 0,11452637 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,0697615 0,11444468 ! non-recombinational repair GO:0000726 19 12 0,000 0,0697615 0,11436311 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,0697615 0,11428166 ! peroxisomal transport GO:0043574 21 12 0,000 0,0697615 0,11420032 ! cartilage condensation GO:0001502 18 12 0,000 0,0697615 0,11411909 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,0697615 0,11403798 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,0697615 0,11395699 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,0697615 0,11387611 ! heart looping GO:0001947 15 12 0,000 0,0697615 0,11379535 ! palate development GO:0060021 15 12 0,000 0,0697615 0,1137147 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,0697615 0,11363417 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,0697615 0,11355375 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,0697615 0,11347344 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,0697615 0,11339325 ! arginine metabolic process GO:0006525 13 12 0,000 0,0697615 0,11331317 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,0697615 0,1132332 ! methionine metabolic process GO:0006555 13 12 0,000 0,0697615 0,11315335 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,0697615 0,1130736 ! Golgi organization GO:0007030 18 12 0,000 0,0697615 0,11299397 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,0697615 0,11291446 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,0697615 0,11283505 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0697615 0,11275576 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,0697615 0,11267658 ! L-amino acid transport GO:0015807 20 12 0,000 0,0697615 0,1125975 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,0697615 0,11251854 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,0697615 0,11243969 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,0697615 0,11236096 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,0697615 0,11228233 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,0697615 0,11220381 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,0697615 0,1121254 ! cerebellum development GO:0021549 13 12 0,000 0,0697615 0,1120471 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,0697615 0,11196891 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,0697615 0,11189083 ! histone methylation GO:0016571 15 12 0,000 0,0697615 0,11181285 ! autonomic nervous system development GO:0048483 23 12 0,000 0,0697615 0,11173499 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,0697615 0,11165723 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,0697615 0,11157959 ! response to gamma radiation GO:0010332 20 12 0,000 0,0697615 0,11150205 ! regulation of epidermis development GO:0045682 17 12 0,000 0,0697615 0,11142461 ! intestinal absorption GO:0050892 19 12 0,000 0,0697615 0,11134729 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,0697615 0,11127007 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,0697615 0,11119296 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,0697615 0,11111596 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,0697615 0,11103906 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,0697615 0,11096227 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,0697615 0,11088559 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,0697615 0,11080901 ! response to cold GO:0009409 14 12 0,000 0,0697615 0,11073254 ! negative regulation of transport GO:0051051 116 73 1,000 0,07133223 0,11314767 ! mitochondrion organization GO:0007005 104 73 1,000 0,07133223 0,11306969 ! protein import into nucleus GO:0006606 118 74 1,000 0,07303522 0,1156894 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,07303522 0,11560978 ! response to inorganic substance GO:0010035 115 75 1,000 0,07475133 0,11824489 ! negative regulation of growth GO:0045926 123 75 1,000 0,07475133 0,11816362 ! nuclear import GO:0051170 121 75 1,000 0,07475133 0,11808246 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07535251 0,11895043 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07535251 0,11886885 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,07535251 0,11878737 ! water transport GO:0006833 17 13 0,000 0,07535251 0,11870601 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07535251 0,11862476 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07535251 0,11854363 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07535251 0,1184626 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07535251 0,11838168 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07535251 0,11830087 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,07535251 0,11822018 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07535251 0,11813959 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07535251 0,11805911 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07535251 0,11797875 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07535251 0,11789849 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07535251 0,11781834 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07535251 0,1177383 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07535251 0,11765837 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07535251 0,11757855 ! NAD metabolic process GO:0019674 21 13 0,000 0,07535251 0,11749883 ! exocrine system development GO:0035272 27 13 0,000 0,07535251 0,11741923 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,07535251 0,11733973 ! bone mineralization GO:0030282 15 13 0,000 0,07535251 0,11726034 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07535251 0,11718105 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07535251 0,11710188 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07535251 0,11702281 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,07535251 0,11694385 ! genitalia development GO:0048806 15 13 0,000 0,07535251 0,11686499 ! regulation of cellular pH GO:0030641 20 13 0,000 0,07535251 0,11678624 ! cellular pigmentation GO:0033059 24 13 0,000 0,07535251 0,1167076 ! tissue regeneration GO:0042246 21 13 0,000 0,07535251 0,11662906 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07535251 0,11655063 ! cofactor transport GO:0051181 19 13 0,000 0,07535251 0,1164723 ! NADP metabolic process GO:0006739 18 13 0,000 0,07535251 0,11639408 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07535251 0,11631596 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07535251 0,11623795 ! gas transport GO:0015669 18 13 0,000 0,07535251 0,11616004 ! regulation of RNA stability GO:0043487 28 13 0,000 0,07535251 0,11608224 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07535251 0,11600454 ! regulation of axon extension GO:0030516 23 13 0,000 0,07535251 0,11592694 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07535251 0,11584945 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07535251 0,11577206 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07535251 0,11569478 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07535251 0,1156176 ! amine biosynthetic process GO:0009309 97 76 1,000 0,07648034 0,11726986 ! regulation of DNA binding GO:0051101 119 77 1,000 0,07822204 0,11986055 ! gland development GO:0048732 148 77 1,000 0,07822204 0,11978075 ! protein ubiquitination GO:0016567 125 77 1,000 0,07822204 0,11970105 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,08091024 0,12373242 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,08091024 0,12365021 ! superoxide anion generation GO:0042554 18 14 0,000 0,08091024 0,1235681 ! regulation of S phase GO:0033261 18 14 0,000 0,08091024 0,1234861 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08091024 0,12340422 ! myotube differentiation GO:0014902 21 14 0,000 0,08091024 0,12332244 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08091024 0,12324077 ! inositol metabolic process GO:0006020 20 14 0,000 0,08091024 0,12315921 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08091024 0,12307775 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08091024 0,1229964 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08091024 0,12291516 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08091024 0,12283403 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08091024 0,12275301 ! response to cAMP GO:0051591 19 14 0,000 0,08091024 0,12267209 ! limbic system development GO:0021761 25 14 0,000 0,08091024 0,12259128 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08091024 0,12251057 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,08091024 0,12242997 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08091024 0,12234948 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08091024 0,12226909 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,08091024 0,12218881 ! glycine metabolic process GO:0006544 22 14 0,000 0,08091024 0,12210863 ! pituitary gland development GO:0021983 23 14 0,000 0,08091024 0,12202856 ! cellular response to starvation GO:0009267 21 14 0,000 0,08091024 0,1219486 ! lysosomal transport GO:0007041 20 14 0,000 0,08091024 0,12186874 ! regulation of heart rate GO:0002027 23 14 0,000 0,08091024 0,12178898 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08091024 0,12170933 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08091024 0,12162978 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,08091024 0,12155033 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,08091024 0,12147099 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,08091024 0,12139175 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,08091024 0,12131262 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08091024 0,12123359 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08091024 0,12115466 ! axon cargo transport GO:0008088 27 14 0,000 0,08091024 0,12107584 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08091024 0,12099711 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08091024 0,12091849 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08091024 0,12083997 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,08091024 0,12076156 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08091024 0,12068324 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08091024 0,12060503 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08091024 0,12052692 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08091024 0,12044891 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08091024 0,120371 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08091024 0,12029319 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08091024 0,12021548 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08091024 0,12013787 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,08091024 0,12006036 ! muscle maintenance GO:0046716 19 14 0,000 0,08091024 0,11998295 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08091024 0,11990564 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08091024 0,11982843 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08091024 0,11975132 ! cell killing GO:0001906 20 14 0,000 0,08091024 0,11967431 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,08091024 0,1195974 ! cilium assembly GO:0042384 20 14 0,000 0,08091024 0,11952059 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08091024 0,11944388 ! T cell activation GO:0042110 134 79 1,000 0,08174264 0,1205953 ! alcohol catabolic process GO:0046164 104 80 1,000 0,08352113 0,12314013 ! protein localization in nucleus GO:0034504 133 80 1,000 0,08352113 0,12306124 ! regulation of neurological system process GO:0031644 122 81 1,000 0,08531147 0,12561869 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,08643488 0,12719145 ! positive regulation of cell size GO:0045793 20 15 0,000 0,08643488 0,12711012 ! metencephalon development GO:0022037 19 15 0,000 0,08643488 0,1270289 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08643488 0,12694779 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,08643488 0,12686677 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,08643488 0,12678586 ! skin development GO:0043588 25 15 0,000 0,08643488 0,12670506 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08643488 0,12662435 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08643488 0,12654375 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,08643488 0,12646325 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08643488 0,12638286 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08643488 0,12630256 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08643488 0,12622237 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08643488 0,12614228 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08643488 0,12606229 ! adult walking behavior GO:0007628 25 15 0,000 0,08643488 0,1259824 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08643488 0,12590262 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08643488 0,12582293 ! centrosome cycle GO:0007098 16 15 0,000 0,08643488 0,12574335 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08643488 0,12566386 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08643488 0,12558448 ! cerebral cortex development GO:0021987 29 15 0,000 0,08643488 0,1255052 ! response to osmotic stress GO:0006970 22 15 0,000 0,08643488 0,12542601 ! vesicle coating GO:0006901 25 15 0,000 0,08643488 0,12534693 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,08643488 0,12526795 ! DNA integration GO:0015074 22 15 0,000 0,08643488 0,12518906 ! peptide secretion GO:0002790 27 15 0,000 0,08643488 0,12511028 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08643488 0,12503159 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08643488 0,12495301 ! neuron recognition GO:0008038 22 15 0,000 0,08643488 0,12487452 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,08643488 0,12479613 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08643488 0,12471784 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08643488 0,12463964 ! biomineral formation GO:0031214 18 15 0,000 0,08643488 0,12456155 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08643488 0,12448355 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08643488 0,12440565 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08643488 0,12432785 ! organic cation transport GO:0015695 19 15 0,000 0,08643488 0,12425015 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08643488 0,12417254 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,08643488 0,12409503 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,08643488 0,12401761 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,08643488 0,12394029 ! defense response to virus GO:0051607 27 15 0,000 0,08643488 0,12386307 ! peptide hormone processing GO:0016486 19 15 0,000 0,08643488 0,12378595 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,08892691 0,1272756 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,08892691 0,12719645 ! regulation of defense response GO:0031347 117 84 1,000 0,0907516 0,12972572 ! protein secretion GO:0009306 27 16 0,000 0,09192663 0,13132376 ! hormone secretion GO:0046879 25 16 0,000 0,09192663 0,13124224 ! endothelial cell migration GO:0043542 22 16 0,000 0,09192663 0,13116082 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,09192663 0,13107951 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09192663 0,1309983 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,09192663 0,13091718 ! glial cell development GO:0021782 24 16 0,000 0,09192663 0,13083617 ! patterning of blood vessels GO:0001569 24 16 0,000 0,09192663 0,13075526 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,09192663 0,13067444 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,09192663 0,13059373 ! protein polyubiquitination GO:0000209 26 16 0,000 0,09192663 0,13051312 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,09192663 0,1304326 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,09192663 0,13035219 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,09192663 0,13027187 ! regulation of protein binding GO:0043393 27 16 0,000 0,09192663 0,13019166 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,09192663 0,13011154 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,09192663 0,13003152 ! protein export from nucleus GO:0006611 24 16 0,000 0,09192663 0,1299516 ! negative regulation of immune response GO:0050777 28 16 0,000 0,09192663 0,12987178 ! DNA replication initiation GO:0006270 25 16 0,000 0,09192663 0,12979205 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,09192663 0,12971242 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,09192663 0,12963289 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,09192663 0,12955346 ! diencephalon development GO:0021536 25 16 0,000 0,09192663 0,12947413 ! oogenesis GO:0048477 23 16 0,000 0,09192663 0,12939489 ! neural crest cell migration GO:0001755 24 16 0,000 0,09192663 0,12931575 ! G1 phase GO:0051318 27 16 0,000 0,09192663 0,12923671 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,09192663 0,12915776 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,09192663 0,12907891 ! steroid catabolic process GO:0006706 22 16 0,000 0,09192663 0,12900015 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,09192663 0,12892149 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,09192663 0,12884293 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,09192663 0,12876446 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,09192663 0,12868609 ! sperm-egg recognition GO:0035036 16 16 0,000 0,09192663 0,12860782 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,09192663 0,12852964 ! nerve development GO:0021675 18 16 0,000 0,09192663 0,12845155 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,09192663 0,12837356 ! negative regulation of translation GO:0017148 22 16 0,000 0,09192663 0,12829566 ! transcription initiation GO:0006352 118 85 1,000 0,09258734 0,12913941 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,09258734 0,12906115 ! regulation of membrane potential GO:0042391 128 85 1,000 0,09258734 0,12898297 ! cell cycle arrest GO:0007050 150 86 1,000 0,09443394 0,13147583 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,09738568 0,13550336 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,09738568 0,13542144 ! negative regulation of defense response GO:0031348 19 17 0,000 0,09738568 0,13533961 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,09738568 0,13525788 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,09738568 0,13517626 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,09738568 0,13509473 ! signal complex assembly GO:0007172 29 17 0,000 0,09738568 0,13501329 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,09738568 0,13493196 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,09738568 0,13485073 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,09738568 0,13476959 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,09738568 0,13468855 ! memory GO:0007613 25 17 0,000 0,09738568 0,13460761 ! keratinization GO:0031424 17 17 0,000 0,09738568 0,13452676 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,09738568 0,13444601 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,09738568 0,13436536 ! retinoid metabolic process GO:0001523 22 17 0,000 0,09738568 0,13428481 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,09738568 0,13420435 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,09738568 0,13412399 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,09738568 0,13404372 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,09738568 0,13396355 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,09738568 0,13388348 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,09738568 0,1338035 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,09738568 0,13372362 ! membrane budding GO:0006900 29 17 0,000 0,09738568 0,13364383 ! heme metabolic process GO:0042168 27 17 0,000 0,09738568 0,13356414 ! actin filament bundle formation GO:0051017 26 17 0,000 0,09738568 0,13348454 ! neuromuscular junction development GO:0007528 23 17 0,000 0,09738568 0,13340504 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,09738568 0,13332563 ! body fluid secretion GO:0007589 27 17 0,000 0,09738568 0,13324632 ! stem cell differentiation GO:0048863 36 17 0,000 0,09738568 0,1331671 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,09738568 0,13308797 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,09738568 0,13300894 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,09738568 0,13293 ! sensory perception of pain GO:0019233 23 17 0,000 0,09738568 0,13285116 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,09738568 0,13277241 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,09738568 0,13269375 ! synaptogenesis GO:0007416 24 17 0,000 0,09738568 0,13261519 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,09738568 0,13253672 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,09738568 0,13245834 ! cell-cell junction organization GO:0045216 25 17 0,000 0,09738568 0,13238006 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,09738568 0,13230186 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,09738568 0,13222376 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,09738568 0,13214576 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,09738568 0,13206784 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,09738568 0,13199002 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,09738568 0,13191228 ! reproductive developmental process GO:0003006 127 89 1,000 0,10003695 0,13542377 ! regulation of T cell activation GO:0050863 128 89 1,000 0,10003695 0,13534411 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,10192505 0,13781753 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,10281222 0,13893543 ! positive regulation of translation GO:0045727 28 18 0,000 0,10281222 0,13885384 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,10281222 0,13877236 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,10281222 0,13869097 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,10281222 0,13860967 ! cAMP metabolic process GO:0046058 33 18 0,000 0,10281222 0,13852847 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,10281222 0,13844736 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,10281222 0,13836635 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,10281222 0,13828544 ! axis specification GO:0009798 26 18 0,000 0,10281222 0,13820461 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,10281222 0,13812389 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,10281222 0,13804326 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,10281222 0,13796272 ! response to retinoic acid GO:0032526 25 18 0,000 0,10281222 0,13788227 ! pigmentation during development GO:0048066 31 18 0,000 0,10281222 0,13780192 ! fucose metabolic process GO:0006004 26 18 0,000 0,10281222 0,13772166 ! response to fungus GO:0009620 19 18 0,000 0,10281222 0,1376415 ! peptide cross-linking GO:0018149 31 18 0,000 0,10281222 0,13756143 ! heart process GO:0003015 27 18 0,000 0,10281222 0,13748145 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,10281222 0,13740157 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,10281222 0,13732177 ! visual learning GO:0008542 35 18 0,000 0,10281222 0,13724208 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,10281222 0,13716247 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,10281222 0,13708295 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,10281222 0,13700353 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,10281222 0,1369242 ! vitamin transport GO:0051180 24 18 0,000 0,10281222 0,13684496 ! hormone transport GO:0009914 27 18 0,000 0,10281222 0,13676582 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,10281222 0,13668676 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,10281222 0,1366078 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,10281222 0,13652892 ! cell-cell recognition GO:0009988 20 18 0,000 0,10281222 0,13645014 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,10281222 0,13637145 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,10281222 0,13629285 ! gut development GO:0048565 26 18 0,000 0,10281222 0,13621434 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,10281222 0,13613592 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,10281222 0,13605759 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,10281222 0,13597935 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,1057308 0,13975911 ! sulfur metabolic process GO:0006790 118 92 1,000 0,1057308 0,13967883 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,10764808 0,14213007 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10820644 0,14278532 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,10820644 0,14270345 ! positive regulation of ossification GO:0045778 30 19 0,000 0,10820644 0,14262167 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10820644 0,14253998 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,10820644 0,14245839 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,10820644 0,14237689 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,10820644 0,14229549 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10820644 0,14221418 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10820644 0,14213296 ! regeneration GO:0031099 32 19 0,000 0,10820644 0,14205183 ! response to alkaloid GO:0043279 32 19 0,000 0,10820644 0,1419708 ! sensory perception of taste GO:0050909 23 19 0,000 0,10820644 0,14188986 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10820644 0,14180901 ! peroxisome organization GO:0007031 29 19 0,000 0,10820644 0,14172825 ! digestive system process GO:0022600 30 19 0,000 0,10820644 0,14164759 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,10820644 0,14156701 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10820644 0,14148653 ! response to vitamin A GO:0033189 26 19 0,000 0,10820644 0,14140614 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10820644 0,14132584 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,10820644 0,14124564 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,10820644 0,14116552 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,10820644 0,14108549 ! response to starvation GO:0042594 30 19 0,000 0,10820644 0,14100556 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,10820644 0,14092571 ! plasma membrane fusion GO:0045026 23 19 0,000 0,10820644 0,14084596 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,10820644 0,1407663 ! cytolysis GO:0019835 20 19 0,000 0,10820644 0,14068672 ! renal system process GO:0003014 35 19 0,000 0,10820644 0,14060724 ! vasodilation GO:0042311 33 19 0,000 0,10820644 0,14052784 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,10820644 0,14044854 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,10820644 0,14036932 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,10820644 0,1402902 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10820644 0,14021116 ! sarcomere organization GO:0045214 23 19 0,000 0,10820644 0,14013221 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,10820644 0,14005335 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,10820644 0,13997458 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10820644 0,1398959 ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10820644 0,13981731 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,10820644 0,1397388 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10820644 0,13966039 ! protein stabilization GO:0050821 26 19 0,000 0,10820644 0,13958206 ! electron transport chain GO:0022900 123 94 1,000 0,10957472 0,14126785 ! regulation of binding GO:0051098 151 95 1,000 0,11151054 0,14368304 ! angiogenesis GO:0001525 149 95 1,000 0,11151054 0,14360259 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,11345536 0,14602536 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,11356854 0,14608928 ! iron ion transport GO:0006826 37 20 0,000 0,11356854 0,14600762 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,11356854 0,14592605 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,11356854 0,14584458 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,11356854 0,14576319 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,11356854 0,14568189 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,11356854 0,14560069 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,11356854 0,14551957 ! spinal cord development GO:0021510 31 20 0,000 0,11356854 0,14543855 ! response to ethanol GO:0045471 37 20 0,000 0,11356854 0,14535762 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,11356854 0,14527677 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,11356854 0,14519602 ! chromosome condensation GO:0030261 31 20 0,000 0,11356854 0,14511535 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,11356854 0,14503478 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,11356854 0,14495429 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,11356854 0,1448739 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,11356854 0,14479359 ! pallium development GO:0021543 38 20 0,000 0,11356854 0,14471337 ! DNA modification GO:0006304 28 20 0,000 0,11356854 0,14463324 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,11356854 0,1445532 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,11356854 0,14447325 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,11356854 0,14439339 ! collagen catabolic process GO:0030574 25 20 0,000 0,11356854 0,14431361 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,11356854 0,14423392 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,11356854 0,14415432 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,11356854 0,14407481 ! actin filament-based movement GO:0030048 34 20 0,000 0,11356854 0,14399539 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,1188987 0,15067053 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,1188987 0,15058756 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,1188987 0,15050468 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,1188987 0,1504219 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,1188987 0,1503392 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,1188987 0,1502566 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,1188987 0,15017409 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,1188987 0,15009166 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,1188987 0,15000933 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 36 21 0,000 0,1188987 0,14992709 ! phototransduction GO:0007602 25 21 0,000 0,1188987 0,14984494 ! dendrite development GO:0016358 35 21 0,000 0,1188987 0,14976288 ! visual behavior GO:0007632 39 21 0,000 0,1188987 0,1496809 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,1188987 0,14959902 ! ovarian follicle development GO:0001541 30 21 0,000 0,1188987 0,14951723 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,1188987 0,14943552 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,1188987 0,14935391 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,1188987 0,14927239 ! cell aging GO:0007569 32 21 0,000 0,1188987 0,14919095 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,1188987 0,1491096 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,1188987 0,14902834 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,1188987 0,14894717 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,1188987 0,14886609 ! fatty acid transport GO:0015908 30 21 0,000 0,1188987 0,1487851 ! immunoglobulin production GO:0002377 33 21 0,000 0,1188987 0,14870419 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,1188987 0,14862338 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,1188987 0,14854265 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,1188987 0,148462 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,1188987 0,14838145 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,1188987 0,14830098 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,1188987 0,1482206 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,1188987 0,14814031 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,1188987 0,1480601 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,1188987 0,14797998 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,1188987 0,14789995 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,1188987 0,14782001 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,1188987 0,14774015 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,1188987 0,14766037 ! calcium ion transport GO:0006816 167 99 1,000 0,1193421 0,14813105 ! protein import GO:0017038 156 99 1,000 0,1193421 0,14805115 ! regulation of translation GO:0006417 151 100 1,000 0,12132121 0,15042522 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,12132121 0,15034417 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,12132121 0,15026321 ! divalent metal ion transport GO:0070838 171 100 1,000 0,12132121 0,15018233 ! protein localization in organelle GO:0033365 161 100 1,000 0,12132121 0,15010155 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,12419712 0,15357708 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,12419712 0,15349455 ! viral genome replication GO:0019079 29 22 0,000 0,12419712 0,15341212 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,12419712 0,15332977 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,12419712 0,15324751 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,12419712 0,15316534 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,12419712 0,15308326 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,12419712 0,15300127 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,12419712 0,15291936 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,12419712 0,15283754 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,12419712 0,15275581 ! lysosome organization GO:0007040 37 22 0,000 0,12419712 0,15267417 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,12419712 0,15259261 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,12419712 0,15251114 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,12419712 0,15242976 ! regulation of behavior GO:0050795 38 22 0,000 0,12419712 0,15234846 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,12419712 0,15226725 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,12419712 0,15218613 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,12419712 0,15210509 ! blastocyst development GO:0001824 37 22 0,000 0,12419712 0,15202414 ! neural tube closure GO:0001843 33 22 0,000 0,12419712 0,15194328 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,12946397 0,15830257 ! neuron fate commitment GO:0048663 32 23 0,000 0,12946397 0,15821846 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,12946397 0,15813443 ! myelination GO:0042552 35 23 0,000 0,12946397 0,1580505 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,12946397 0,15796665 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,12946397 0,15788289 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,12946397 0,15779922 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,12946397 0,15771564 ! vesicle targeting GO:0006903 32 23 0,000 0,12946397 0,15763215 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,12946397 0,15754875 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,12946397 0,15746543 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,12946397 0,15738221 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,12946397 0,15729907 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,12946397 0,15721602 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,12946397 0,15713305 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,12946397 0,15705018 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,12946397 0,15696739 ! cell fate determination GO:0001709 45 23 0,000 0,12946397 0,15688469 ! pentose metabolic process GO:0019321 31 23 0,000 0,12946397 0,15680207 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,12946397 0,15671954 ! spermatid development GO:0007286 33 23 0,000 0,12946397 0,1566371 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,12946397 0,15655475 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,12946397 0,15647248 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,12946397 0,1563903 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,12946397 0,15630821 ! telomere organization GO:0032200 32 23 0,000 0,12946397 0,1562262 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,12946397 0,15614428 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,12946397 0,15606244 ! regulation of amine transport GO:0051952 38 23 0,000 0,12946397 0,15598069 ! liver development GO:0001889 40 23 0,000 0,12946397 0,15589902 ! initiation of viral infection GO:0019059 42 24 0,000 0,13469945 0,16211865 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,13469945 0,16203386 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,13469945 0,16194916 ! superoxide metabolic process GO:0006801 32 24 0,000 0,13469945 0,16186455 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,13469945 0,16178002 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,13469945 0,16169559 ! sperm motility GO:0030317 27 24 0,000 0,13469945 0,16161124 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,13469945 0,16152698 ! vacuole organization GO:0007033 39 24 0,000 0,13469945 0,16144281 ! receptor metabolic process GO:0043112 37 24 0,000 0,13469945 0,16135872 ! neural crest cell development GO:0014032 39 24 0,000 0,13469945 0,16127472 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,13469945 0,16119081 ! primary neural tube formation GO:0014020 35 24 0,000 0,13469945 0,16110699 ! negative regulation of cell development GO:0010721 56 24 0,000 0,13469945 0,16102326 GO:0050768|negative regulation of neurogenesis, ! glutathione metabolic process GO:0006749 29 24 0,000 0,13469945 0,16093961 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,13469945 0,16085605 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,13990375 0,16698423 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,13990375 0,16689762 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,13990375 0,1668111 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,13990375 0,16672467 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,13990375 0,16663833 ! peptide transport GO:0015833 43 25 0,000 0,13990375 0,16655208 ! male gonad development GO:0008584 33 25 0,000 0,13990375 0,16646592 ! iron ion homeostasis GO:0055072 39 25 0,000 0,13990375 0,16637984 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,13990375 0,16629386 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,13990375 0,16620796 ! phospholipid transport GO:0015914 35 25 0,000 0,13990375 0,16612216 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,13990375 0,16603644 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,13990375 0,16595081 ! detection of light stimulus GO:0009583 30 25 0,000 0,13990375 0,16586527 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,13990375 0,16577981 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,13990375 0,16569445 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,13990375 0,16560917 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,14507704 0,17164464 ! translational initiation GO:0006413 43 26 0,000 0,14507704 0,17155639 ! regulation of pH GO:0006885 36 26 0,000 0,14507704 0,17146823 ! circadian rhythm GO:0007623 42 26 0,000 0,14507704 0,17138017 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,14507704 0,17129219 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,14507704 0,1712043 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,14507704 0,1711165 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,14507704 0,1710288 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,14507704 0,17094118 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,14507704 0,17085365 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,1502195 0,17681927 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,1502195 0,17672883 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,1502195 0,17663848 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,1502195 0,17654822 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,1502195 0,17645805 ! acute-phase response GO:0006953 42 27 0,000 0,1502195 0,17636797 ! myofibril assembly GO:0030239 36 27 0,000 0,1502195 0,17627799 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,1502195 0,1761881 ! response to ionizing radiation GO:0010212 47 27 0,000 0,1502195 0,1760983 ! natural killer cell activation GO:0030101 35 27 0,000 0,1502195 0,17600859 ! lipid oxidation GO:0034440 38 27 0,000 0,1502195 0,17591897 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,1502195 0,17582944 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,1502195 0,17574001 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,1502195 0,17565067 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,1502195 0,17556141 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,1502195 0,17547225 ! gene silencing GO:0016458 41 27 0,000 0,1502195 0,17538318 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,15533133 0,18125929 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,15533133 0,18116737 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,15533133 0,18107555 ! cell junction assembly GO:0034329 56 28 0,000 0,15533133 0,18098382 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,15533133 0,18089218 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,15533133 0,18080064 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,15533133 0,18070919 ! response to organic cyclic substance GO:0014070 47 28 0,000 0,15533133 0,18061783 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,15533133 0,18052656 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,15533133 0,18043539 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,15533133 0,1803443 ! ensheathment of neurons GO:0007272 43 28 0,000 0,15533133 0,18025331 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,15533133 0,18016241 ! neural tube formation GO:0001841 41 28 0,000 0,15533133 0,1800716 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,1604127 0,18586862 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1604127 0,18577503 ! ovulation cycle process GO:0022602 41 29 0,000 0,1604127 0,18568154 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1604127 0,18558813 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1604127 0,18549483 ! mismatch repair GO:0006298 34 29 0,000 0,1604127 0,18540161 ! muscle cell development GO:0055001 38 29 0,000 0,1604127 0,18530849 ! telencephalon development GO:0021537 52 29 0,000 0,1604127 0,18521547 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1604127 0,18512253 ! eye morphogenesis GO:0048592 51 29 0,000 0,1604127 0,18502969 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1604127 0,18493695 ! tissue homeostasis GO:0001894 42 29 0,000 0,1604127 0,18484429 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,16546379 0,19056921 ! collagen metabolic process GO:0032963 40 30 0,000 0,16546379 0,19047383 ! organic anion transport GO:0015711 51 30 0,000 0,16546379 0,19037855 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,16546379 0,19028336 ! spliceosome assembly GO:0000245 49 30 0,000 0,16546379 0,19018826 ! spindle organization GO:0007051 37 30 0,000 0,16546379 0,19009327 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,16546379 0,18999836 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,16546379 0,18990355 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,16546379 0,18980884 ! ceramide metabolic process GO:0006672 43 30 0,000 0,16546379 0,18971422 ! ovulation cycle GO:0042698 43 30 0,000 0,16546379 0,18961969 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,16546379 0,18952526 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,16546379 0,18943092 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,16546379 0,18933668 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,16546379 0,18924252 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,17048478 0,19488817 ! negative regulation of secretion GO:0051048 49 31 0,000 0,17048478 0,19479135 ! glial cell differentiation GO:0010001 55 31 0,000 0,17048478 0,19469463 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,17048478 0,19459801 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,17048478 0,19450148 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,17048478 0,19440505 ! odontogenesis GO:0042476 50 31 0,000 0,17048478 0,19430872 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,17048478 0,19421248 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,17048478 0,19411633 ! metanephros development GO:0001656 58 31 0,000 0,17048478 0,19402028 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,17048478 0,19392433 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,17048478 0,19382847 ! RNA modification GO:0009451 40 31 0,000 0,17048478 0,1937327 ! regulation of muscle development GO:0048634 48 32 0,000 0,17547585 0,1993059 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,17547585 0,19920752 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,17547585 0,19910925 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,17547585 0,19901107 ! meiosis I GO:0007127 52 32 0,000 0,17547585 0,19891298 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,17547585 0,198815 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,17547585 0,19871711 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,17547585 0,19861931 ! peripheral nervous system development GO:0007422 53 32 0,000 0,17547585 0,19852162 ! regulation of protein stability GO:0031647 48 32 0,000 0,17547585 0,19842401 ! cytokine production GO:0001816 44 32 0,000 0,17547585 0,19832651 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,17547585 0,1982291 ! vesicle localization GO:0051648 47 32 0,000 0,17547585 0,19813178 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,18043717 0,2036337 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,18043717 0,20353383 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,18043717 0,20343406 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,18043717 0,20333439 ! sister chromatid segregation GO:0000819 46 33 0,000 0,18043717 0,20323481 ! actomyosin structure organization GO:0031032 43 33 0,000 0,18043717 0,20313533 ! cell junction organization GO:0034330 63 33 0,000 0,18043717 0,20303595 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,18043717 0,20293667 ! nucleus organization GO:0006997 49 33 0,000 0,18043717 0,20283748 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,18043717 0,20273839 ! female gonad development GO:0008585 49 33 0,000 0,18043717 0,20263939 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,18043717 0,2025405 ! positive regulation of cell development GO:0010720 54 33 0,000 0,18043717 0,2024417 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,18043717 0,20234299 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,18043717 0,20224439 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,18043717 0,20214587 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,18536892 0,20756987 ! mRNA catabolic process GO:0006402 48 34 0,000 0,18536892 0,20746886 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,18536892 0,20736795 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,18536892 0,20726714 ! feeding behavior GO:0007631 45 34 0,000 0,18536892 0,20716643 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,18536892 0,20706581 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,18536892 0,20696529 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,18536892 0,20686487 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,18536892 0,20676455 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,18536892 0,20666433 ! female gamete generation GO:0007292 43 34 0,000 0,18536892 0,2065642 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,18536892 0,20646417 ! aerobic respiration GO:0009060 47 34 0,000 0,18536892 0,20636423 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,18536892 0,2062644 ! embryonic organ development GO:0048568 45 34 0,000 0,18536892 0,20616465 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,18536892 0,20606501 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,19027127 0,21141252 ! Notch signaling pathway GO:0007219 56 35 0,000 0,19027127 0,21131044 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,19027127 0,21120845 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,19027127 0,21110657 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,19027127 0,21100478 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,19027127 0,21090309 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,19027127 0,2108015 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,19027127 0,21070001 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,19027127 0,21059861 ! pigment metabolic process GO:0042440 61 35 0,000 0,19027127 0,21049731 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,1951444 0,21578467 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,1951444 0,21568098 ! negative regulation of binding GO:0051100 58 36 0,000 0,1951444 0,21557739 ! neural tube development GO:0021915 50 36 0,000 0,1951444 0,21547389 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,1951444 0,2153705 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1951444 0,2152672 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,1951444 0,21516401 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,19998848 0,22039938 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,19998848 0,22029382 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,19998848 0,22018837 ! learning GO:0007612 67 37 0,000 0,19998848 0,22008302 ! ion transmembrane transport GO:0034220 56 37 0,000 0,19998848 0,21997776 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,19998848 0,21987261 ! regulation of protein secretion GO:0050708 51 37 0,000 0,19998848 0,21976756 ! amino acid activation GO:0043038 52 37 0,000 0,19998848 0,21966261 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,19998848 0,21955776 ! gliogenesis GO:0042063 71 38 0,000 0,20480368 0,22473687 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,20480368 0,2246297 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,20480368 0,22452263 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,20480368 0,22441566 ! pigmentation GO:0043473 74 38 0,000 0,20480368 0,2243088 ! maintenance of location in cell GO:0051651 69 38 0,000 0,20480368 0,22420203 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,20959018 0,22933274 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,20959018 0,22922368 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,20959018 0,22911474 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,20959018 0,2290059 ! male sex differentiation GO:0046661 53 39 0,000 0,20959018 0,22889716 ! chromatin remodeling GO:0006338 68 39 0,000 0,20959018 0,22878852 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,20959018 0,22867999 ! synapse organization GO:0050808 55 39 0,000 0,20959018 0,22857155 ! regulation of tube size GO:0035150 60 40 0,000 0,21434813 0,23364963 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,21434813 0,23353894 ! peptide metabolic process GO:0006518 56 40 0,000 0,21434813 0,23342837 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,21434813 0,23331789 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,21434813 0,23320753 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,21434813 0,23309726 ! B cell differentiation GO:0030183 62 40 0,000 0,21434813 0,2329871 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,21434813 0,23287705 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,21434813 0,2327671 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,21434813 0,23265725 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,21907772 0,23767866 ! endosome transport GO:0016197 71 41 0,000 0,21907772 0,2375666 ! striated muscle contraction GO:0006941 62 41 0,000 0,21907772 0,23745465 ! biopolymer methylation GO:0043414 62 41 0,000 0,21907772 0,2373428 ! mitochondrial transport GO:0006839 60 42 0,000 0,2237791 0,24232201 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,2237791 0,24220797 ! cellular component disassembly GO:0022411 64 42 0,000 0,2237791 0,24209405 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,2237791 0,24198023 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,2237791 0,24186651 ! excretion GO:0007588 63 42 0,000 0,2237791 0,24175291 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,2237791 0,24163941 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,2237791 0,24152602 ! activation of caspase activity GO:0006919 65 43 0,000 0,22845245 0,24645433 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,22845245 0,24633879 ! tRNA processing GO:0008033 49 43 0,000 0,22845245 0,24622336 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,22845245 0,24610803 ! methylation GO:0032259 64 43 0,000 0,22845245 0,24599281 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,23309793 0,25087751 ! glycolysis GO:0006096 53 44 0,000 0,23309793 0,25076017 ! regulation of action potential GO:0001508 71 44 0,000 0,23309793 0,25064294 ! regulation of ion transport GO:0043269 57 44 0,000 0,23309793 0,25052581 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,23309793 0,2504088 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,23309793 0,2502919 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,23309793 0,2501751 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,23309793 0,25005841 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,23309793 0,24994184 ! RNA catabolic process GO:0006401 64 45 0,000 0,2377157 0,25477452 ! regulation of translational initiation GO:0006446 64 45 0,000 0,2377157 0,25465585 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,2377157 0,2545373 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,2377157 0,25441885 ! cell recognition GO:0008037 58 45 0,000 0,2377157 0,25430052 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,24230593 0,25909049 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,24686879 0,26384675 ! viral infectious cycle GO:0019058 71 47 0,000 0,24686879 0,2637242 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,24686879 0,26360177 ! endocrine system development GO:0035270 83 47 0,000 0,24686879 0,26347945 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,24686879 0,26335724 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,24686879 0,26323514 ! chloride transport GO:0006821 67 48 0,000 0,25140442 0,26794725 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,25140442 0,26782314 GO:0010952|positive regulation of peptidase activity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,25140442 0,26769915 ! nuclear export GO:0051168 69 48 0,000 0,25140442 0,26757527 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,255913 0,27224787 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,255913 0,272122 ! sensory perception of smell GO:0007608 61 49 0,000 0,255913 0,27199625 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,255913 0,27187062 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,255913 0,2717451 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,255913 0,2716197 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,255913 0,27149442 ! cartilage development GO:0051216 70 49 0,000 0,255913 0,27136925 ! proton transport GO:0015992 75 50 0,000 0,26039468 0,27599436 ! hydrogen transport GO:0006818 77 51 0,000 0,26484962 0,28058688 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,26484962 0,2804577 ! transition metal ion transport GO:0000041 74 52 0,000 0,26927798 0,28501581 ! aging GO:0007568 79 52 0,000 0,26927798 0,28488471 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,26927798 0,28475373 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,27367992 0,28927565 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,27367992 0,28914278 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,27367992 0,28901002 ! kidney development GO:0001822 90 53 0,000 0,27367992 0,28887738 ! amino acid transport GO:0006865 84 54 0,000 0,2780556 0,29336141 ! regulation of mitosis GO:0007088 84 54 0,000 0,2780556 0,2932269 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,2780556 0,29309252 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,2780556 0,29295825 ! detection of external stimulus GO:0009581 66 54 0,000 0,2780556 0,29282412 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,2780556 0,2926901 ! exocytosis GO:0006887 74 55 0,000 0,28240516 0,2971326 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,28240516 0,29699674 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,28240516 0,296861 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,28672876 0,30126823 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,29102656 0,30564434 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,29102656 0,30550484 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,29102656 0,30536546 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,29102656 0,30522622 ! camera-type eye development GO:0043010 88 57 0,000 0,29102656 0,3050871 ! secondary metabolic process GO:0019748 84 57 0,000 0,29102656 0,30494811 ! gonad development GO:0008406 79 57 0,000 0,29102656 0,30480924 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,29529871 0,30914294 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,29954536 0,31344601 ! actin filament organization GO:0007015 95 59 0,000 0,29954536 0,31330347 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,29954536 0,31316106 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,30376666 0,31742995 ! regulation of heart contraction GO:0008016 91 60 0,000 0,30376666 0,3172858 ! meiosis GO:0007126 96 61 0,000 0,30796277 0,32152263 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,30796277 0,32137675 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,30796277 0,321231 ! urogenital system development GO:0001655 101 61 0,000 0,30796277 0,32108539 ! extracellular matrix organization GO:0030198 103 61 0,000 0,30796277 0,3209399 ! amine catabolic process GO:0009310 90 62 0,000 0,31213382 0,3251394 ! neurotransmitter transport GO:0006836 81 62 0,000 0,31213382 0,32499221 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,31213382 0,32484515 ! meiotic cell cycle GO:0051321 97 62 0,000 0,31213382 0,32469823 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,32040137 0,3331479 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,32040137 0,33299735 ! hexose catabolic process GO:0019320 82 64 0,000 0,32040137 0,33284695 ! reproductive structure development GO:0048608 90 65 0,000 0,32449816 0,33695068 ! B cell activation GO:0042113 104 65 0,000 0,32449816 0,33679863 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,32857048 0,3408715 ! axon guidance GO:0007411 99 66 0,000 0,32857048 0,34071781 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,32857048 0,34056427 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,33261849 0,34460474 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,33261849 0,34444958 ! acute inflammatory response GO:0002526 92 68 0,000 0,33664232 0,34845965 ! learning or memory GO:0007611 123 68 0,000 0,33664232 0,3483029 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,33664232 0,34814629 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,33664232 0,34798982 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,33664232 0,34783349 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,33664232 0,3476773 ! rhythmic process GO:0048511 105 68 0,000 0,33664232 0,34752125 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,34064212 0,35149255 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,34064212 0,35133493 ! response to drug GO:0042493 108 69 0,000 0,34064212 0,35117745 ! humoral immune response GO:0006959 86 70 0,000 0,34461804 0,35511715 ! eye development GO:0001654 111 70 0,000 0,34461804 0,35495812 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,3485702 0,35886816 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,3485702 0,35870759 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,35249876 0,36258817 ! regulation of blood pressure GO:0008217 107 73 0,000 0,35640385 0,36644115 ! tube morphogenesis GO:0035239 118 73 0,000 0,35640385 0,36627742 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,35640385 0,36611383 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,35640385 0,36595038 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,36028561 0,36977105 ! digestion GO:0007586 97 74 0,000 0,36028561 0,36960612 ! blood coagulation GO:0007596 116 75 0,000 0,36414419 0,37339796 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,36414419 0,37323156 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,36414419 0,37306531 ! tRNA metabolic process GO:0006399 95 76 0,000 0,3679797 0,37682694 ! response to unfolded protein GO:0006986 99 76 0,000 0,3679797 0,37665924 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,3717923 0,38039248 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,3717923 0,38022334 ! sex differentiation GO:0007548 105 77 0,000 0,3717923 0,38005436 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,3717923 0,37988552 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,3717923 0,37971683 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,37558212 0,38341717 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,37558212 0,38324707 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,3793493 0,38691946 ! cellular respiration GO:0045333 107 79 0,000 0,3793493 0,38674795 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,3793493 0,3865766 ! regulation of lyase activity GO:0051339 133 79 0,000 0,3793493 0,3864054 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,3793493 0,38623434 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,38309396 0,38987438 ! forebrain development GO:0030900 131 80 0,000 0,38309396 0,38970195 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,38681624 0,39331448 ! hemostasis GO:0007599 125 81 0,000 0,38681624 0,39314067 ! mRNA transport GO:0051028 121 81 0,000 0,38681624 0,39296703 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,38681624 0,39279353 ! response to protein stimulus GO:0051789 111 81 0,000 0,38681624 0,39262019 ! vitamin metabolic process GO:0006766 103 81 0,000 0,38681624 0,392447 ! detection of stimulus GO:0051606 108 82 0,000 0,39051627 0,3960262 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,39419419 0,39957983 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,39785013 0,40310806 ! sterol metabolic process GO:0016125 120 84 0,000 0,39785013 0,40293055 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,40148421 0,40643208 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,40509656 0,40990853 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,40868732 0,41336009 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,40868732 0,41317839 ! female pregnancy GO:0007565 130 87 0,000 0,40868732 0,41299686 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,41225661 0,41642082 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,41225661 0,41623802 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,41225661 0,41605538 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,41225661 0,4158729 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,41225661 0,41569058 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,41580457 0,41908436 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,41580457 0,41890079 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,41580457 0,41871738 ! hormone metabolic process GO:0042445 121 90 0,000 0,4193313 0,42208402 ! RNA localization GO:0006403 135 91 0,000 0,42283695 0,4254265 ! ATP metabolic process GO:0046034 137 91 0,000 0,42283695 0,42524048 ! response to virus GO:0009615 122 91 0,000 0,42283695 0,42505462 ! DNA recombination GO:0006310 146 92 0,000 0,42632163 0,42837036 ! response to oxidative stress GO:0006979 141 94 0,000 0,4332286 0,43512043 ! carboxylic acid transport GO:0046942 147 95 0,000 0,43665113 0,43836648 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,44005319 0,44158916 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,44005319 0,44139658 ! protein maturation GO:0051604 129 96 0,000 0,44005319 0,44120416 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,4434349 0,44440099 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,4434349 0,44420744 ! extracellular structure organization GO:0043062 156 99 0,000 0,45013775 0,45072566 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,45345913 0,45385379 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,45345913 0,45365638 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,45345913 0,45345913