pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1132-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 7,000 5,054E-13 1,235E-09 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 4,000 1,801E-08 2,2E-05 ! regulation of epithelial cell proliferation GO:0050678 122 45 5,000 4,949E-08 4,031E-05 ! cell growth GO:0016049 90 46 4,000 1,927E-06 1,177E-03 ! positive regulation of protein ubiquitination GO:0031398 14 7 2,000 2,977E-06 1,455E-03 ! regulation of protein ubiquitination GO:0031396 28 16 2,000 4,625E-05 0,01883234 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 9,293E-05 0,0324339 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,247E-04 0,03808792 ! peptidyl-serine modification GO:0018209 50 22 2,000 1,247E-04 0,03385593 ! inner ear receptor cell differentiation GO:0060113 42 22 2,000 1,247E-04 0,03047034 ! mechanoreceptor differentiation GO:0042490 48 24 2,000 1,629E-04 0,03616926 ! benzene and derivative metabolic process GO:0042537 12 5 1,000 1,946E-04 0,03962433 ! microvillus organization GO:0032528 8 5 1,000 1,946E-04 0,0365763 GO:0030033|microvillus assembly, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 1,946E-04 0,03396371 ! meiotic chromosome segregation GO:0045132 10 5 1,000 1,946E-04 0,03169946 ! indolalkylamine catabolic process GO:0046218 8 5 1,000 1,946E-04 0,02971825 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! circadian behavior GO:0048512 15 5 1,000 1,946E-04 0,02797011 ! protein insertion into membrane GO:0051205 17 5 1,000 1,946E-04 0,02641622 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 2,595E-04 0,0333672 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 2,602E-04 0,03178116 ! response to interferon-gamma GO:0034341 16 6 1,000 2,911E-04 0,03386443 ! vascular smooth muscle contraction GO:0014829 13 6 1,000 2,911E-04 0,03232514 ! establishment of spindle localization GO:0051293 16 6 1,000 2,911E-04 0,0309197 GO:0051653|spindle localization, ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 2,911E-04 0,02963138 ! metallo-sulfur cluster assembly GO:0031163 6 6 1,000 2,911E-04 0,02844612 GO:0016226|iron-sulfur cluster assembly, ! sleep GO:0030431 16 7 1,000 4,063E-04 0,03818096 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 4,063E-04 0,03676685 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 4,063E-04 0,03545375 ! rhythmic behavior GO:0007622 17 7 1,000 4,063E-04 0,03423121 ! cysteine metabolic process GO:0006534 13 7 1,000 4,063E-04 0,03309017 ! tryptophan metabolic process GO:0006568 11 7 1,000 4,063E-04 0,03202274 ! peptidyl-threonine modification GO:0018210 26 7 1,000 4,063E-04 0,03102203 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 4,792E-04 0,03547669 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 5,257E-04 0,03777128 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 5,402E-04 0,03770687 ! ER overload response GO:0006983 13 8 1,000 5,402E-04 0,03665946 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 1,000 5,402E-04 0,03566866 ! NAD biosynthetic process GO:0009435 17 8 1,000 5,402E-04 0,03473001 ! UTP metabolic process GO:0046051 10 9 1,000 6,925E-04 0,04338088 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! induction of an organ GO:0001759 17 10 1,000 8,631E-04 0,05271612 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 1,000 8,631E-04 0,05143036 ! negative regulation of BMP signaling pathway GO:0030514 19 10 1,000 8,631E-04 0,05020583 ! CTP metabolic process GO:0046036 11 10 1,000 8,631E-04 0,04903825 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 11 10 1,000 8,631E-04 0,04792375 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 8,711E-04 0,04729231 ! epithelial cell differentiation GO:0030855 83 43 2,000 9,334E-04 0,04957262 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,052E-03 0,05467473 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 1,052E-03 0,05353567 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,052E-03 0,0524431 ! L-serine metabolic process GO:0006563 21 11 1,000 1,052E-03 0,05139424 ! vasoconstriction GO:0042310 20 11 1,000 1,052E-03 0,05038651 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 1,000 1,052E-03 0,04941754 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 1,000 1,052E-03 0,04848513 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,137E-03 0,05143916 ! positive regulation of protein transport GO:0051222 80 46 2,000 1,137E-03 0,05050391 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,259E-03 0,05490464 ! histone acetylation GO:0016573 27 12 1,000 1,259E-03 0,0539414 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,259E-03 0,05301137 ! developmental induction GO:0031128 22 12 1,000 1,259E-03 0,05211287 GO:0045168|cell-cell signaling involved in cell fate specification, ! localization within membrane GO:0051668 26 12 1,000 1,259E-03 0,05124433 ! positive regulation of cell cycle GO:0045787 96 48 2,000 1,287E-03 0,05154788 ! JAK-STAT cascade GO:0007259 82 48 2,000 1,287E-03 0,05071647 ! cartilage condensation GO:0001502 22 13 1,000 1,483E-03 0,05750941 ! indolalkylamine metabolic process GO:0006586 19 13 1,000 1,483E-03 0,05661083 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! asymmetric protein localization GO:0008105 24 13 1,000 1,483E-03 0,05573989 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 1,000 1,483E-03 0,05489535 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,483E-03 0,05407601 ! gland morphogenesis GO:0022612 31 13 1,000 1,483E-03 0,05328078 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 1,483E-03 0,05250859 ! aromatic amino acid family catabolic process GO:0009074 20 13 1,000 1,483E-03 0,05175847 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 1,000 1,483E-03 0,05102948 ! biogenic amine catabolic process GO:0042402 24 13 1,000 1,483E-03 0,05032073 ! regulation of fatty acid oxidation GO:0046320 34 13 1,000 1,483E-03 0,04963141 ! inner ear development GO:0048839 89 53 2,000 1,715E-03 0,0566258 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 2,000 1,715E-03 0,05587079 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 1,725E-03 0,05545553 ! serine family amino acid biosynthetic process GO:0009070 19 14 1,000 1,725E-03 0,05473533 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,985E-03 0,06216478 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 1,000 1,985E-03 0,06137789 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 1,985E-03 0,06061066 ! intermediate filament cytoskeleton organization GO:0045104 34 15 1,000 1,985E-03 0,05986238 ! regulation of intracellular transport GO:0032386 108 57 2,000 2,115E-03 0,06300514 ! sulfur amino acid biosynthetic process GO:0000097 31 16 1,000 2,262E-03 0,06657114 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 1,000 2,262E-03 0,06577862 ! intermediate filament-based process GO:0045103 36 16 1,000 2,262E-03 0,06500476 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 1,000 2,262E-03 0,06424889 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 2,262E-03 0,0635104 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 2,556E-03 0,0709533 ! myoblast differentiation GO:0045445 50 17 1,000 2,556E-03 0,07015607 ! NAD metabolic process GO:0019674 33 17 1,000 2,556E-03 0,06937656 ! cellular amino acid derivative catabolic process GO:0042219 30 17 1,000 2,556E-03 0,06861418 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 2,867E-03 0,07612967 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 1,000 2,867E-03 0,07531107 ! regulation of BMP signaling pathway GO:0030510 33 18 1,000 2,867E-03 0,07450989 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 1,000 2,867E-03 0,07372558 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 3,195E-03 0,08130358 ! ear development GO:0043583 114 66 2,000 3,212E-03 0,08090476 ! protein amino acid acetylation GO:0006473 41 20 1,000 3,54E-03 0,08823628 ! response to vitamin GO:0033273 36 20 1,000 3,54E-03 0,087345 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 3,54E-03 0,08647155 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 3,54E-03 0,0856154 ! aromatic compound catabolic process GO:0019439 31 20 1,000 3,54E-03 0,08477603 ! lung development GO:0030324 165 69 2,000 3,643E-03 0,08639545 ! smooth muscle contraction GO:0006939 48 21 1,000 3,901E-03 0,09163068 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 3,901E-03 0,09075801 ! respiratory tube development GO:0030323 171 72 2,000 4,106E-03 0,09463847 ! G1 phase GO:0051318 44 22 1,000 4,278E-03 0,09768299 ! response to cytokine stimulus GO:0034097 69 22 1,000 4,278E-03 0,09677852 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 1,000 4,278E-03 0,09589064 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 4,278E-03 0,09501891 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 4,434E-03 0,09759852 ! respiratory system development GO:0060541 175 74 2,000 4,434E-03 0,0967271 ! sulfur amino acid metabolic process GO:0000096 48 23 1,000 4,672E-03 0,10101109 ! gluconeogenesis GO:0006094 38 23 1,000 4,672E-03 0,10012502 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 4,672E-03 0,09925437 GO:0010810|regulation of cell-substrate adhesion, ! cell-matrix adhesion GO:0007160 181 76 2,000 4,778E-03 0,10062904 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 5,082E-03 0,10611746 ! protein amino acid O-linked glycosylation GO:0006493 45 24 1,000 5,082E-03 0,10521816 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 5,082E-03 0,10433397 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 5,082E-03 0,10346452 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 5,082E-03 0,10260944 ! aromatic amino acid family metabolic process GO:0009072 37 24 1,000 5,082E-03 0,10176838 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 1,000 5,082E-03 0,100941 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 5,508E-03 0,10851763 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 5,508E-03 0,10764949 ! cell-substrate adhesion GO:0031589 189 82 2,000 5,904E-03 0,1144688 ! pyruvate metabolic process GO:0006090 43 26 1,000 5,95E-03 0,11445056 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 5,95E-03 0,11355642 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 5,95E-03 0,11267613 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 5,95E-03 0,11180939 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 5,95E-03 0,11095589 ! positive regulation of nuclear division GO:0051785 41 26 1,000 5,95E-03 0,11011531 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 5,95E-03 0,10928738 ! water-soluble vitamin biosynthetic process GO:0042364 44 26 1,000 5,95E-03 0,1084718 ! regulation of chromosome organization GO:0033044 49 27 1,000 6,407E-03 0,11594436 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 6,88E-03 0,12358553 ! protein amino acid acylation GO:0043543 59 28 1,000 6,88E-03 0,12268345 ! circadian rhythm GO:0007623 56 28 1,000 6,88E-03 0,12179444 ! negative regulation of protein modification process GO:0031400 66 28 1,000 6,88E-03 0,12091822 ! vitamin biosynthetic process GO:0009110 48 28 1,000 6,88E-03 0,12005452 ! regulation of protein transport GO:0051223 165 87 2,000 6,953E-03 0,12047297 GO:0070201|regulation of establishment of protein localization, ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 7,368E-03 0,12676266 ! somitogenesis GO:0001756 52 29 1,000 7,368E-03 0,12587621 ! positive regulation of protein modification process GO:0031401 156 90 2,000 7,633E-03 0,12948826 ! nicotinamide metabolic process GO:0006769 56 30 1,000 7,872E-03 0,1326216 GO:0046496|nicotinamide nucleotide metabolic process, ! alkaloid metabolic process GO:0009820 57 31 1,000 8,39E-03 0,14038894 ! cofactor biosynthetic process GO:0051188 161 95 2,000 8,849E-03 0,14706527 ! spindle organization GO:0007051 50 32 1,000 8,923E-03 0,1472967 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 8,923E-03 0,14630813 ! hexose biosynthetic process GO:0019319 53 32 1,000 8,923E-03 0,14533274 ! regulation of protein localization GO:0032880 188 97 2,000 9,366E-03 0,15152732 ! leukocyte chemotaxis GO:0030595 55 33 1,000 9,472E-03 0,15223134 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 1,000 9,472E-03 0,15123637 ! interphase of mitotic cell cycle GO:0051329 224 98 2,000 9,631E-03 0,15277569 ! forebrain development GO:0030900 210 98 2,000 9,631E-03 0,15179004 ! cell fate specification GO:0001708 56 34 1,000 0,01003447 0,15714232 ! serine family amino acid metabolic process GO:0009069 56 34 1,000 0,01003447 0,15614141 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01017311 0,15729691 GO:0060538|skeletal muscle organ development, ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01061182 0,16304832 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01120355 0,17106419 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 1,000 0,01120355 0,17000168 ! monosaccharide biosynthetic process GO:0046364 57 36 1,000 0,01120355 0,16895229 ! xenobiotic metabolic process GO:0006805 55 37 1,000 0,01180951 0,17699772 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01180951 0,17591847 ! tissue remodeling GO:0048771 78 37 1,000 0,01180951 0,1748523 ! meiosis I GO:0007127 74 38 1,000 0,01242956 0,18292423 ! glycogen metabolic process GO:0005977 63 38 1,000 0,01242956 0,18182888 ! glucan metabolic process GO:0044042 64 39 1,000 0,01306358 0,1899662 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 93 40 1,000 0,01371142 0,19820708 ! establishment or maintenance of cell polarity GO:0007163 96 41 1,000 0,01437295 0,20654777 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,01437295 0,20533989 ! gliogenesis GO:0042063 91 41 1,000 0,01437295 0,20414605 ! alcohol biosynthetic process GO:0046165 65 42 1,000 0,01504804 0,21249924 ! ribonucleoside metabolic process GO:0009119 64 42 1,000 0,01504804 0,21127798 ! cytokinesis GO:0000910 84 42 1,000 0,01504804 0,21007068 ! response to xenobiotic stimulus GO:0009410 63 42 1,000 0,01504804 0,2088771 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01573656 0,21720011 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 76 43 1,000 0,01573656 0,21597988 GO:0050880|regulation of blood vessel size, ! segmentation GO:0035282 78 43 1,000 0,01573656 0,21477329 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,01573656 0,21358011 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,01643838 0,22187266 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,01643838 0,22065358 ! phagocytosis GO:0006909 105 44 1,000 0,01643838 0,21944782 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 1,000 0,01715335 0,22774808 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 1,000 0,01788137 0,23613075 ! leukocyte migration GO:0050900 75 46 1,000 0,01788137 0,23486123 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,01862229 0,24328483 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,019376 0,2517849 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,019376 0,25045271 ! mitochondrial transport GO:0006839 94 48 1,000 0,019376 0,24913453 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,019376 0,24783017 ! protein homooligomerization GO:0051260 84 49 1,000 0,02014235 0,25629048 ! regulation of ossification GO:0030278 123 50 1,000 0,02092124 0,26482169 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02203048 0,27742508 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02203048 0,27600238 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02203048 0,27459421 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02203048 0,27320033 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02203048 0,27182053 ! neuron fate determination GO:0048664 7 5 0,000 0,02203048 0,2704546 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02203048 0,26910232 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02203048 0,26776351 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02203048 0,26643795 ! polyol transport GO:0015791 12 5 0,000 0,02203048 0,26512544 ! response to superoxide GO:0000303 10 5 0,000 0,02203048 0,26382581 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02203048 0,26253885 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02203048 0,26126439 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02203048 0,26000225 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02203048 0,25875224 ! female meiosis GO:0007143 10 5 0,000 0,02203048 0,25751419 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02203048 0,25628793 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02203048 0,25507329 ! hypothalamus development GO:0021854 9 5 0,000 0,02203048 0,25387012 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02203048 0,25267824 ! cobalt ion transport GO:0006824 11 5 0,000 0,02203048 0,2514975 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02203048 0,25032774 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02203048 0,24916882 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02203048 0,24802058 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02203048 0,24688287 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02203048 0,24575555 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02203048 0,24463848 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02203048 0,24353152 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02203048 0,24243453 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02203048 0,24134738 ! transposition GO:0032196 9 5 0,000 0,02203048 0,24026993 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02203048 0,23920207 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,02203048 0,23814365 ! negative chemotaxis GO:0050919 16 5 0,000 0,02203048 0,23709456 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02203048 0,23605467 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02203048 0,23502386 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02203048 0,23400202 ! behavioral response to pain GO:0048266 10 5 0,000 0,02203048 0,23298903 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02203048 0,23198476 ! Notch receptor processing GO:0007220 11 5 0,000 0,02203048 0,23098912 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02203048 0,23000199 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02203048 0,22902325 ! micturition GO:0060073 9 5 0,000 0,02203048 0,22805282 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02203048 0,22709057 ! copulation GO:0007620 9 5 0,000 0,02203048 0,22613641 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02203048 0,22519023 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02203048 0,22425194 ! bioluminescence GO:0008218 9 5 0,000 0,02203048 0,22332143 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02203048 0,22239862 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02203048 0,22148339 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02203048 0,22057568 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02203048 0,21967537 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02203048 0,21878238 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02203048 0,21789662 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02203048 0,217018 ! grooming behavior GO:0007625 6 5 0,000 0,02203048 0,21614645 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02203048 0,21528186 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02203048 0,21442416 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02203048 0,21357327 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02203048 0,21272911 ! response to protozoan GO:0001562 13 5 0,000 0,02203048 0,21189159 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02203048 0,21106065 ! lymph vessel development GO:0001945 10 5 0,000 0,02203048 0,21023619 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02203048 0,20941815 ! endochondral ossification GO:0001958 17 5 0,000 0,02203048 0,20860645 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02203048 0,20780102 ! single strand break repair GO:0000012 8 5 0,000 0,02203048 0,20700179 ! parathyroid gland development GO:0060017 14 5 0,000 0,02203048 0,20620868 ! anagen GO:0042640 7 5 0,000 0,02203048 0,20542162 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02203048 0,20464055 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02203048 0,2038654 ! cytokine secretion GO:0050663 15 5 0,000 0,02203048 0,20309609 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02203048 0,20233257 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02203048 0,20157477 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02203048 0,20082263 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02203048 0,20007608 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02203048 0,19933506 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02203048 0,1985995 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02203048 0,19786936 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02203048 0,19714456 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02203048 0,19642505 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02203048 0,19571078 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02203048 0,19500168 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02203048 0,19429771 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02203048 0,19359879 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02203048 0,19290489 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02203048 0,19221595 ! valine metabolic process GO:0006573 12 5 0,000 0,02203048 0,1915319 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02203048 0,19085271 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02203048 0,19017832 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02203048 0,18950868 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02203048 0,18884374 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02203048 0,18818344 ! polyol catabolic process GO:0046174 9 5 0,000 0,02203048 0,18752775 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02203048 0,18687661 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02203048 0,18622998 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02203048 0,18558781 ! muscle cell migration GO:0014812 8 5 0,000 0,02203048 0,18495005 ! mitochondrial fission GO:0000266 8 5 0,000 0,02203048 0,18431666 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02203048 0,18368759 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02203048 0,18306281 ! mRNA transcription GO:0009299 10 5 0,000 0,02203048 0,18244225 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02203048 0,18182589 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02203048 0,18121369 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02203048 0,18060559 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02203048 0,18000155 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02203048 0,17940155 ! monocyte activation GO:0042117 10 5 0,000 0,02203048 0,17880553 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02203048 0,17821346 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02203048 0,1776253 ! response to food GO:0032094 6 5 0,000 0,02203048 0,177041 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02203048 0,17646054 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02203048 0,17588387 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02203048 0,17531096 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02203048 0,17474177 ! forebrain neuron development GO:0021884 13 5 0,000 0,02203048 0,17417626 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02203048 0,1736144 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02203048 0,17305616 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02203048 0,17250149 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02203048 0,17195037 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02203048 0,17140275 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02203048 0,17085862 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02203048 0,17031793 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02203048 0,16978065 ! lipid glycosylation GO:0030259 7 5 0,000 0,02203048 0,16924674 ! nucleobase transport GO:0015851 6 5 0,000 0,02203048 0,16871619 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02203048 0,16818895 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02203048 0,167665 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02203048 0,1671443 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02203048 0,16662683 ! basic amino acid transport GO:0015802 12 5 0,000 0,02203048 0,16611255 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02203048 0,16560143 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02203048 0,16509345 ! actin nucleation GO:0045010 11 5 0,000 0,02203048 0,16458858 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02203048 0,16408678 ! depurination GO:0045007 5 5 0,000 0,02203048 0,16358804 ! depyrimidination GO:0045008 10 5 0,000 0,02203048 0,16309232 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02203048 0,16259959 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02203048 0,16210983 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02203048 0,16162302 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02203048 0,16113912 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02203048 0,1606581 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02203048 0,16017996 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02203048 0,15970464 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02203048 0,15923214 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02203048 0,15876243 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02203048 0,15829548 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02203048 0,15783128 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02203048 0,15736978 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02203048 0,15691098 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02203048 0,15645484 ! response to arsenic GO:0046685 11 5 0,000 0,02203048 0,15600135 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02203048 0,15555048 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02203048 0,1551022 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02203048 0,15465651 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02203048 0,15421337 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02203048 0,15377276 ! response to mercury ion GO:0046689 8 5 0,000 0,02203048 0,15333466 ! response to cadmium ion GO:0046686 7 5 0,000 0,02203048 0,15289905 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02203048 0,15246591 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02203048 0,15203521 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02203048 0,15160694 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02203048 0,15118108 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02203048 0,1507576 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02203048 0,15033649 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02203048 0,14991773 ! decidualization GO:0046697 11 5 0,000 0,02203048 0,14950129 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02203048 0,14908716 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02203048 0,14867532 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02203048 0,14826574 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02203048 0,14785842 ! embryonic cleavage GO:0040016 6 5 0,000 0,02203048 0,14745333 ! peroxisome fission GO:0016559 5 5 0,000 0,02203048 0,14705045 ! histone demethylation GO:0016577 13 5 0,000 0,02203048 0,14664977 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02203048 0,14625126 ! mitotic recombination GO:0006312 9 5 0,000 0,02203048 0,14585492 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02203048 0,14546072 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02203048 0,14506864 ! metaphase plate congression GO:0051310 7 5 0,000 0,02203048 0,14467867 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02203048 0,14429079 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02203048 0,14390499 ! enteric nervous system development GO:0048484 8 5 0,000 0,02203048 0,14352124 ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02203048 0,14313953 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02203048 0,14275985 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02203048 0,14238218 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02203048 0,1420065 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02203048 0,1416328 ! B cell homeostasis GO:0001782 13 5 0,000 0,02203048 0,14126106 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02203048 0,14089127 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02203048 0,14052341 ! metaphase GO:0051323 11 5 0,000 0,02203048 0,14015746 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02203048 0,13979342 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02203048 0,13943126 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02203048 0,13907097 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02203048 0,13871254 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02203048 0,13835595 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02203048 0,13800119 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02203048 0,13764825 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02203048 0,1372971 ! response to redox state GO:0051775 6 5 0,000 0,02203048 0,13694775 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02203048 0,13660016 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02203048 0,13625434 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02203048 0,13591026 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02203048 0,13556792 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02203048 0,1352273 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02203048 0,13488838 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02203048 0,13455116 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02203048 0,13421562 GO:0033015|tetrapyrrole catabolic process, ! striatum development GO:0021756 14 5 0,000 0,02203048 0,13388175 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02203048 0,13354954 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02203048 0,13321897 ! glial cell migration GO:0008347 10 5 0,000 0,02203048 0,13289004 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02203048 0,13256272 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02203048 0,13223701 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02203048 0,1319129 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02203048 0,13159038 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02203048 0,13126943 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02203048 0,13095004 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02203048 0,1306322 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02203048 0,1303159 ! neuroprotection GO:0043526 8 5 0,000 0,02203048 0,13000112 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02203048 0,12968787 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02203048 0,12937612 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02203048 0,12906586 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02203048 0,12875709 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02203048 0,1284498 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02203048 0,12814396 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02203048 0,12783958 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02203048 0,12753665 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02203048 0,12723514 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02203048 0,12693506 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02203048 0,12663639 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02203048 0,12633912 ! spindle assembly GO:0051225 6 5 0,000 0,02203048 0,12604324 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02203048 0,12574875 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02203048 0,12545563 ! protein palmitoylation GO:0018345 12 5 0,000 0,02203048 0,12516387 ! drug metabolic process GO:0017144 7 5 0,000 0,02203048 0,12487347 ! stem cell division GO:0017145 11 5 0,000 0,02203048 0,12458441 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,02203048 0,12429669 ! organ regeneration GO:0031100 7 5 0,000 0,02203048 0,12401029 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02203048 0,12372521 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02203048 0,12344143 ! positive regulation of binding GO:0051099 88 52 1,000 0,02251609 0,1258737 ! cellular amino acid biosynthetic process GO:0008652 80 52 1,000 0,02251609 0,12558632 ! histone modification GO:0016570 104 52 1,000 0,02251609 0,12530025 ! amino acid activation GO:0043038 98 52 1,000 0,02251609 0,12501547 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cartilage development GO:0051216 99 53 1,000 0,02333181 0,12925082 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,02415956 0,13353351 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 0,02415956 0,13323208 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,02499923 0,13755205 ! response to UV GO:0009411 120 55 1,000 0,02499923 0,13724294 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,02585068 0,14159912 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02637836 0,14416628 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02637836 0,14384448 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02637836 0,14352411 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02637836 0,14320517 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02637836 0,14288764 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02637836 0,14257152 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02637836 0,14225679 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02637836 0,14194345 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02637836 0,14163149 ! response to oxygen radical GO:0000305 11 6 0,000 0,02637836 0,14132089 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02637836 0,14101166 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02637836 0,14070377 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02637836 0,14039723 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02637836 0,14009202 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02637836 0,13978813 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02637836 0,13948556 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02637836 0,13918429 ! forebrain regionalization GO:0021871 9 6 0,000 0,02637836 0,13888433 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02637836 0,13858565 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02637836 0,13828826 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02637836 0,13799214 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02637836 0,13769728 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02637836 0,13740368 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02637836 0,13711133 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02637836 0,13682023 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02637836 0,13653035 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02637836 0,13624171 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02637836 0,13595428 ! malate metabolic process GO:0006108 13 6 0,000 0,02637836 0,13566806 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02637836 0,13538304 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02637836 0,13509922 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02637836 0,13481658 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02637836 0,13453513 ! protein refolding GO:0042026 15 6 0,000 0,02637836 0,13425485 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02637836 0,13397573 ! opsonization GO:0008228 8 6 0,000 0,02637836 0,13369777 ! mating behavior GO:0007617 7 6 0,000 0,02637836 0,13342097 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02637836 0,1331453 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02637836 0,13287078 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02637836 0,13259738 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02637836 0,13232511 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02637836 0,13205395 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02637836 0,1317839 ! toxin metabolic process GO:0009404 11 6 0,000 0,02637836 0,13151495 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02637836 0,1312471 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02637836 0,13098034 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02637836 0,13071466 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02637836 0,13045006 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,02637836 0,13018652 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02637836 0,12992405 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02637836 0,12966263 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02637836 0,12940226 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02637836 0,12914294 ! thymic T cell selection GO:0045061 16 6 0,000 0,02637836 0,12888465 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02637836 0,1286274 ! protein lipoylation GO:0009249 10 6 0,000 0,02637836 0,12837117 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02637836 0,12811596 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02637836 0,12786176 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02637836 0,12760857 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02637836 0,12735638 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02637836 0,12710518 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02637836 0,12685497 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02637836 0,12660575 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02637836 0,1263575 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02637836 0,12611023 ! hyperosmotic response GO:0006972 10 6 0,000 0,02637836 0,12586392 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02637836 0,12561857 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02637836 0,12537418 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02637836 0,12513073 ! urea metabolic process GO:0019627 7 6 0,000 0,02637836 0,12488823 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02637836 0,12464667 ! neutrophil activation GO:0042119 7 6 0,000 0,02637836 0,12440604 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02637836 0,12416633 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02637836 0,12392755 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02637836 0,12368969 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02637836 0,12345273 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02637836 0,12321669 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02637836 0,12298154 ! neuron apoptosis GO:0051402 15 6 0,000 0,02637836 0,12274729 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02637836 0,12251393 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02637836 0,12228146 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02637836 0,12204986 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02637836 0,12181914 ! carnitine transport GO:0015879 10 6 0,000 0,02637836 0,1215893 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02637836 0,12136031 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02637836 0,12113219 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02637836 0,12090493 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02637836 0,12067852 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02637836 0,12045295 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02637836 0,12022822 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02637836 0,12000433 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02637836 0,11978128 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02637836 0,11955905 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02637836 0,11933764 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02637836 0,11911706 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02637836 0,11889728 ! response to UV-C GO:0010225 14 6 0,000 0,02637836 0,11867832 ! astrocyte development GO:0014002 16 6 0,000 0,02637836 0,11846016 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02637836 0,1182428 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02637836 0,11802624 ! interaction with symbiont GO:0051702 14 6 0,000 0,02637836 0,11781047 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02637836 0,11759549 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02637836 0,11738129 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02637836 0,11716787 ! response to copper ion GO:0046688 10 6 0,000 0,02637836 0,11695522 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02637836 0,11674335 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02637836 0,11653224 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02637836 0,11632189 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02637836 0,1161123 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02637836 0,11590347 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02637836 0,11569538 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02637836 0,11548804 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02637836 0,11528144 ! hair follicle maturation GO:0048820 8 6 0,000 0,02637836 0,11507558 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02637836 0,11487046 ! Schwann cell development GO:0014044 15 6 0,000 0,02637836 0,11466606 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02637836 0,11446239 ! response to pheromone GO:0019236 6 6 0,000 0,02637836 0,11425945 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02637836 0,11405722 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02637836 0,1138557 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02637836 0,1136549 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02637836 0,1134548 ! subpallium development GO:0021544 15 6 0,000 0,02637836 0,11325541 ! neural tube patterning GO:0021532 8 6 0,000 0,02637836 0,11305671 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02637836 0,11285872 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02637836 0,11266141 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02637836 0,11246479 ! G2 phase GO:0051319 16 6 0,000 0,02637836 0,11226886 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02637836 0,11207361 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02637836 0,11187904 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02637836 0,11168514 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02637836 0,11149192 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02637836 0,11129936 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02637836 0,11110746 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02637836 0,11091623 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02637836 0,11072565 ! receptor internalization GO:0031623 11 6 0,000 0,02637836 0,11053572 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,02637836 0,11034645 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,02637836 0,11015782 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02637836 0,10996984 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02637836 0,1097825 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02637836 0,10959579 ! protein deubiquitination GO:0016579 16 6 0,000 0,02637836 0,10940972 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02637836 0,10922428 ! protein destabilization GO:0031648 9 6 0,000 0,02637836 0,10903947 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02637836 0,10885528 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02637836 0,10867172 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02637836 0,10848877 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02637836 0,10830643 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02637836 0,10812471 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02637836 0,1079436 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02637836 0,10776309 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02637836 0,10758318 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02637836 0,10740388 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02637836 0,10722517 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02637836 0,10704706 ! neural plate development GO:0001840 9 6 0,000 0,02637836 0,10686953 ! catecholamine transport GO:0051937 9 6 0,000 0,02637836 0,10669259 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02637836 0,10651624 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02637836 0,10634047 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02637836 0,10616528 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02637836 0,10599067 ! maternal placenta development GO:0001893 12 6 0,000 0,02637836 0,10581663 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02637836 0,10564316 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02637836 0,10547026 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02637836 0,10529792 ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02637836 0,10512615 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02637836 0,10495493 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02637836 0,10478427 GO:0055081|anion homeostasis, ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 1,000 0,0267138 0,10594451 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,0267138 0,1057728 ! muscle fiber development GO:0048747 131 57 1,000 0,0267138 0,10560165 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,0267138 0,10543105 ! positive regulation of cell migration GO:0030335 137 58 1,000 0,02758848 0,1087075 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,02758848 0,10853245 ! sulfur compound biosynthetic process GO:0044272 108 58 1,000 0,02758848 0,10835796 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,02758848 0,10818403 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,02758848 0,10801066 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,02758848 0,10783784 ! establishment of organelle localization GO:0051656 122 59 1,000 0,02847458 0,11112366 ! heterocycle catabolic process GO:0046700 100 60 1,000 0,02937201 0,11444308 ! tRNA transcription GO:0009304 17 7 0,000 0,03070703 0,11945424 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03070703 0,11926433 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03070703 0,11907502 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03070703 0,11888631 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03070703 0,1186982 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03070703 0,11851069 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03070703 0,11832376 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03070703 0,11813742 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03070703 0,11795167 ! prostate gland development GO:0030850 14 7 0,000 0,03070703 0,11776651 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03070703 0,11758192 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03070703 0,11739791 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03070703 0,11721448 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03070703 0,11703161 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03070703 0,11684932 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03070703 0,1166676 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03070703 0,11648644 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03070703 0,11630584 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03070703 0,1161258 ! glycolipid transport GO:0046836 11 7 0,000 0,03070703 0,11594631 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03070703 0,11576738 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03070703 0,11558901 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03070703 0,11541118 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03070703 0,11523389 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03070703 0,11505715 ! mRNA stabilization GO:0048255 18 7 0,000 0,03070703 0,11488096 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,03070703 0,1147053 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03070703 0,11453017 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03070703 0,11435559 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03070703 0,11418153 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03070703 0,114008 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03070703 0,113835 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03070703 0,11366252 ! lipoprotein transport GO:0042953 14 7 0,000 0,03070703 0,11349057 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03070703 0,11331913 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03070703 0,11314821 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03070703 0,11297781 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03070703 0,11280792 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03070703 0,11263853 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03070703 0,11246966 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03070703 0,11230129 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03070703 0,11213343 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03070703 0,11196607 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03070703 0,1117992 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03070703 0,11163283 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03070703 0,11146696 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03070703 0,11130158 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03070703 0,11113669 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03070703 0,11097228 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03070703 0,11080837 ! spinal cord patterning GO:0021511 14 7 0,000 0,03070703 0,11064493 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03070703 0,11048198 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03070703 0,11031951 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03070703 0,11015751 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03070703 0,10999599 ! adrenal gland development GO:0030325 17 7 0,000 0,03070703 0,10983494 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03070703 0,10967436 ! ovulation GO:0030728 10 7 0,000 0,03070703 0,10951425 ! adenohypophysis development GO:0021984 11 7 0,000 0,03070703 0,10935461 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03070703 0,10919544 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03070703 0,10903672 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03070703 0,10887847 ! microtubule nucleation GO:0007020 21 7 0,000 0,03070703 0,10872067 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03070703 0,10856333 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03070703 0,10840645 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03070703 0,10825002 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03070703 0,10809404 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03070703 0,10793851 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03070703 0,10778343 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03070703 0,10762879 ! galactose metabolic process GO:0006012 13 7 0,000 0,03070703 0,10747459 ! vesicle fusion GO:0006906 20 7 0,000 0,03070703 0,10732084 ! response to dietary excess GO:0002021 8 7 0,000 0,03070703 0,10716752 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03070703 0,10701464 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03070703 0,1068622 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03070703 0,10671019 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03070703 0,10655861 ! organ growth GO:0035265 15 7 0,000 0,03070703 0,10640747 ! nucleoside transport GO:0015858 11 7 0,000 0,03070703 0,10625675 ! nucleoside salvage GO:0043174 11 7 0,000 0,03070703 0,10610646 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03070703 0,10595659 ! male sex determination GO:0030238 15 7 0,000 0,03070703 0,10580714 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03070703 0,10565812 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03070703 0,10550951 ! parturition GO:0007567 16 7 0,000 0,03070703 0,10536133 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03070703 0,10521355 ! rRNA modification GO:0000154 14 7 0,000 0,03070703 0,1050662 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03070703 0,10491925 ! spindle checkpoint GO:0031577 16 7 0,000 0,03070703 0,10477272 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03070703 0,10462659 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03070703 0,10448087 ! monocyte differentiation GO:0030224 16 7 0,000 0,03070703 0,10433556 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03070703 0,10419064 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03070703 0,10404614 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03070703 0,10390203 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03070703 0,10375832 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03070703 0,10361501 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03070703 0,10347209 ! fibrinolysis GO:0042730 11 7 0,000 0,03070703 0,10332957 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03070703 0,10318743 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03070703 0,10304569 ! eating behavior GO:0042755 8 7 0,000 0,03070703 0,10290434 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03070703 0,10276338 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03070703 0,1026228 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03070703 0,1024826 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03070703 0,10234279 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03070703 0,10220336 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03070703 0,10206431 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03070703 0,10192563 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03070703 0,10178733 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03070703 0,10164941 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03070703 0,10151186 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03070703 0,10137468 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03070703 0,10123787 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03070703 0,10110143 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03070703 0,10096536 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03070703 0,10082966 ! histone ubiquitination GO:0016574 9 7 0,000 0,03070703 0,10069431 ! regulation of meiosis GO:0040020 12 7 0,000 0,03070703 0,10055934 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03070703 0,10042472 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03070703 0,10029046 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03070703 0,10015656 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03070703 0,10002302 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03070703 0,09988983 ! transcription termination GO:0006353 14 7 0,000 0,03070703 0,099757 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03070703 0,09962452 ! anaphase GO:0051322 18 7 0,000 0,03070703 0,09949239 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03070703 0,09936061 ! axonal fasciculation GO:0007413 19 7 0,000 0,03070703 0,09922919 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03070703 0,0990981 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03070703 0,09896737 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03070703 0,09883698 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,03070703 0,09870693 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03070703 0,09857722 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03070703 0,09844785 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03070703 0,09831883 ! antibiotic transport GO:0042891 9 7 0,000 0,03070703 0,09819014 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03070703 0,09806178 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03070703 0,09793377 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03070703 0,09780608 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03070703 0,09767873 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03070703 0,09755171 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03070703 0,09742502 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03070703 0,09729866 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03070703 0,09717262 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03070703 0,09704691 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03070703 0,09692153 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03070703 0,09679647 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03070703 0,09667173 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03070703 0,09654732 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03070703 0,09642322 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03070703 0,09629944 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03070703 0,09617598 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03070703 0,09605284 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03070703 0,09593001 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03070703 0,09580749 ! muscle adaptation GO:0043500 13 7 0,000 0,03070703 0,09568529 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03070703 0,09556339 ! retina homeostasis GO:0001895 12 7 0,000 0,03070703 0,09544181 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03070703 0,09532054 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03070703 0,09519957 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03070703 0,09507892 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03070703 0,09495856 ! nucleoside metabolic process GO:0009116 91 62 1,000 0,03120033 0,09636208 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,03120033 0,09624041 ! regulation of mitosis GO:0007088 112 63 1,000 0,032131 0,09898616 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,032131 0,0988615 ! water-soluble vitamin metabolic process GO:0006767 107 63 1,000 0,032131 0,09873714 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,03307252 0,10150272 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 0,03307252 0,10137537 ! positive regulation of cell motion GO:0051272 157 65 1,000 0,03402478 0,10416359 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,03498767 0,10697732 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,03501657 0,10693185 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,03501657 0,10679835 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,03501657 0,10666519 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,03501657 0,10653236 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,03501657 0,10639985 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03501657 0,10626768 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03501657 0,10613583 ! male meiosis GO:0007140 9 8 0,000 0,03501657 0,10600431 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,03501657 0,10587312 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,03501657 0,10574225 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,03501657 0,10561171 ! meiotic prophase I GO:0007128 14 8 0,000 0,03501657 0,10548148 ! response to zinc ion GO:0010043 12 8 0,000 0,03501657 0,10535158 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,03501657 0,105222 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03501657 0,10509273 ! oligopeptide transport GO:0006857 16 8 0,000 0,03501657 0,10496378 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,03501657 0,10483515 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,03501657 0,10470683 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,03501657 0,10457883 ! signal peptide processing GO:0006465 12 8 0,000 0,03501657 0,10445114 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,03501657 0,10432376 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,03501657 0,10419669 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03501657 0,10406993 ! succinate metabolic process GO:0006105 17 8 0,000 0,03501657 0,10394348 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,03501657 0,10381733 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,03501657 0,10369149 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,03501657 0,10356596 ! estrogen metabolic process GO:0008210 17 8 0,000 0,03501657 0,10344073 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,03501657 0,1033158 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,03501657 0,10319117 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,03501657 0,10306685 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03501657 0,10294282 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03501657 0,10281909 ! reflex GO:0060004 17 8 0,000 0,03501657 0,10269566 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03501657 0,10257252 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,03501657 0,10244968 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,03501657 0,10232713 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03501657 0,10220488 ! pigment granule organization GO:0048753 17 8 0,000 0,03501657 0,10208291 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,03501657 0,10196124 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,03501657 0,10183986 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,03501657 0,10171877 ! astrocyte differentiation GO:0048708 19 8 0,000 0,03501657 0,10159796 ! histidine catabolic process GO:0006548 10 8 0,000 0,03501657 0,10147744 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03501657 0,10135721 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,03501657 0,10123726 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,03501657 0,10111759 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,03501657 0,10099821 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,03501657 0,10087911 ! melanin metabolic process GO:0006582 17 8 0,000 0,03501657 0,10076029 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,03501657 0,10064174 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,03501657 0,10052348 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,03501657 0,1004055 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,03501657 0,10028779 ! macrophage activation GO:0042116 13 8 0,000 0,03501657 0,10017035 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03501657 0,1000532 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,03501657 0,09993631 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,03501657 0,0998197 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,03501657 0,09970336 ! purine salvage GO:0043101 12 8 0,000 0,03501657 0,09958729 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,03501657 0,09947149 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03501657 0,09935596 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,03501657 0,0992407 ! osteoblast development GO:0002076 17 8 0,000 0,03501657 0,0991257 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,03501657 0,09901097 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,03501657 0,09889651 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,03501657 0,09878231 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,03501657 0,09866838 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03501657 0,0985547 ! response to UV-B GO:0010224 17 8 0,000 0,03501657 0,09844129 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,03501657 0,09832814 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03501657 0,09821525 ! intermediate filament organization GO:0045109 12 8 0,000 0,03501657 0,09810262 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,03501657 0,09799024 ! cellular extravasation GO:0045123 13 8 0,000 0,03501657 0,09787813 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,03501657 0,09776627 ! response to antibiotic GO:0046677 11 8 0,000 0,03501657 0,09765466 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,03501657 0,09754331 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,03501657 0,09743221 ! DNA topological change GO:0006265 12 8 0,000 0,03501657 0,09732137 ! response to tropane GO:0014073 15 8 0,000 0,03501657 0,09721077 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,03501657 0,09710043 ! melanosome transport GO:0032402 13 8 0,000 0,03501657 0,09699034 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 0,000 0,03501657 0,0968805 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,03501657 0,09677091 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03501657 0,09666156 ! mast cell activation GO:0045576 14 8 0,000 0,03501657 0,09655246 ! multicellular organismal aging GO:0010259 20 8 0,000 0,03501657 0,09644361 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,03501657 0,096335 ! gas homeostasis GO:0033483 14 8 0,000 0,03501657 0,09622664 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,03501657 0,09611852 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,03501657 0,09601064 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,03501657 0,09590301 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03501657 0,09579561 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03501657 0,09568846 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,03501657 0,09558154 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03501657 0,09547487 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,03501657 0,09536843 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,03501657 0,09526223 ! intracellular lipid transport GO:0032365 16 8 0,000 0,03501657 0,09515626 ! response to tumor cell GO:0002347 16 8 0,000 0,03501657 0,09505054 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03501657 0,09494504 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,03501657 0,09483978 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,03501657 0,09473475 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03501657 0,09462996 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,03501657 0,09452539 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,03501657 0,09442106 ! hormone catabolic process GO:0042447 17 8 0,000 0,03501657 0,09431696 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,03501657 0,09421309 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,03501657 0,09410944 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,03501657 0,09400602 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,03501657 0,09390283 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03501657 0,09379987 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,03501657 0,09369713 ! adult feeding behavior GO:0008343 10 8 0,000 0,03501657 0,09359462 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,03501657 0,09349233 ! ATP catabolic process GO:0006200 11 8 0,000 0,03501657 0,09339026 ! blastocyst growth GO:0001832 19 8 0,000 0,03501657 0,09328842 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03501657 0,0931868 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03501657 0,0930854 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,03501657 0,09298422 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03501657 0,09288326 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,03501657 0,09278252 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,03501657 0,092682 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,03501657 0,09258169 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,03501657 0,0924816 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,03501657 0,09238173 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,03501657 0,09228207 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03501657 0,09218263 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,03501657 0,0920834 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,03501657 0,09198439 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03501657 0,09188559 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,03501657 0,091787 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,03501657 0,09168862 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,03501657 0,09159045 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,03501657 0,09149249 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,03501657 0,09139475 ! chromosome segregation GO:0007059 127 67 1,000 0,03596107 0,09375977 ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,03596107 0,09365981 ! secondary metabolic process GO:0019748 125 67 1,000 0,03596107 0,09356007 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,03694488 0,09601739 ! extracellular matrix organization GO:0030198 146 68 1,000 0,03694488 0,09591535 ! regulation of lipase activity GO:0060191 137 68 1,000 0,03694488 0,09581353 ! cell projection assembly GO:0030031 138 68 1,000 0,03694488 0,09571193 ! cellular amino acid catabolic process GO:0009063 120 69 1,000 0,03793898 0,09818319 ! axon extension GO:0048675 16 9 0,000 0,03930708 0,10161607 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,03930708 0,10150865 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03930708 0,10140146 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03930708 0,1012945 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03930708 0,10118776 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03930708 0,10108125 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03930708 0,10097496 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03930708 0,10086889 ! reproductive behavior GO:0019098 22 9 0,000 0,03930708 0,10076305 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03930708 0,10065743 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03930708 0,10055203 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03930708 0,10044685 ! RNA methylation GO:0001510 16 9 0,000 0,03930708 0,10034189 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,03930708 0,10023715 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03930708 0,10013262 ! artery development GO:0060840 25 9 0,000 0,03930708 0,10002832 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03930708 0,09992423 ! regulation of glycolysis GO:0006110 20 9 0,000 0,03930708 0,09982036 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03930708 0,0997167 ! equilibrioception GO:0050957 20 9 0,000 0,03930708 0,09961326 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03930708 0,09951004 ! chemosensory behavior GO:0007635 21 9 0,000 0,03930708 0,09940702 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03930708 0,09930422 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03930708 0,09920164 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03930708 0,09909926 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03930708 0,0989971 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03930708 0,09889514 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03930708 0,0987934 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03930708 0,09869187 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03930708 0,09859054 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03930708 0,09848942 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03930708 0,09838851 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03930708 0,0982878 ! protein targeting to ER GO:0045047 25 9 0,000 0,03930708 0,09818731 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03930708 0,09808701 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03930708 0,09798692 ! T cell selection GO:0045058 27 9 0,000 0,03930708 0,09788704 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 0,000 0,03930708 0,09778736 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03930708 0,09768788 ! glycine catabolic process GO:0006546 15 9 0,000 0,03930708 0,0975886 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03930708 0,09748953 ! endosome organization GO:0007032 20 9 0,000 0,03930708 0,09739065 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03930708 0,09729198 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03930708 0,09719351 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03930708 0,09709523 ! mannose metabolic process GO:0006013 13 9 0,000 0,03930708 0,09699716 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03930708 0,09689928 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03930708 0,0968016 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03930708 0,09670411 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03930708 0,09660683 ! receptor clustering GO:0043113 20 9 0,000 0,03930708 0,09650973 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03930708 0,09641284 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03930708 0,09631613 ! retinol metabolic process GO:0042572 20 9 0,000 0,03930708 0,09621962 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03930708 0,09612331 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03930708 0,09602719 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03930708 0,09593125 ! macrophage differentiation GO:0030225 15 9 0,000 0,03930708 0,09583551 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03930708 0,09573997 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03930708 0,09564461 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03930708 0,09554944 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03930708 0,09545446 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03930708 0,09535967 ! response to amine stimulus GO:0014075 13 9 0,000 0,03930708 0,09526506 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03930708 0,09517065 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03930708 0,09507642 ! erythrocyte development GO:0048821 17 9 0,000 0,03930708 0,09498238 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03930708 0,09488852 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03930708 0,09479485 ! renal water homeostasis GO:0003091 15 9 0,000 0,03930708 0,09470137 ! postreplication repair GO:0006301 25 9 0,000 0,03930708 0,09460806 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03930708 0,09451495 ! icosanoid secretion GO:0032309 15 9 0,000 0,03930708 0,09442201 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03930708 0,09432926 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03930708 0,09423669 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03930708 0,0941443 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03930708 0,09405209 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03930708 0,09396006 ! sterol catabolic process GO:0016127 14 9 0,000 0,03930708 0,09386822 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03930708 0,09377655 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03930708 0,09368506 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03930708 0,09359375 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03930708 0,09350261 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03930708 0,09341166 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03930708 0,09332088 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03930708 0,09323028 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03930708 0,09313985 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03930708 0,0930496 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03930708 0,09295952 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03930708 0,09286962 ! purine base metabolic process GO:0006144 25 9 0,000 0,03930708 0,09277989 ! pigment granule transport GO:0051904 17 9 0,000 0,03930708 0,09269033 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03930708 0,09260095 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03930708 0,09251174 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03930708 0,0924227 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03930708 0,09233383 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03930708 0,09224513 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03930708 0,09215661 ! mitochondrion localization GO:0051646 18 9 0,000 0,03930708 0,09206825 ! coenzyme biosynthetic process GO:0009108 119 72 1,000 0,04098195 0,09589932 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,04098195 0,09580755 ! regulation of caspase activity GO:0043281 136 74 1,000 0,04306006 0,10056953 ! organelle localization GO:0051640 155 74 1,000 0,04306006 0,10047348 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,04357862 0,10158643 ! regulation of developmental growth GO:0048638 16 10 0,000 0,04357862 0,10148959 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,04357862 0,10139293 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04357862 0,10129646 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04357862 0,10120017 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04357862 0,10110406 ! associative learning GO:0008306 21 10 0,000 0,04357862 0,10100814 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,04357862 0,1009124 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,04357862 0,10081684 ! phosphate transport GO:0006817 24 10 0,000 0,04357862 0,10072146 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04357862 0,10062626 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,04357862 0,10053124 ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,04357862 0,1004364 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,04357862 0,10034173 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04357862 0,10024725 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04357862 0,10015294 ! social behavior GO:0035176 29 10 0,000 0,04357862 0,10005881 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04357862 0,09996486 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04357862 0,09987109 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,04357862 0,09977749 ! androgen metabolic process GO:0008209 17 10 0,000 0,04357862 0,09968406 ! phospholipid efflux GO:0033700 19 10 0,000 0,04357862 0,09959081 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,04357862 0,09949774 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04357862 0,09940484 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04357862 0,09931211 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,04357862 0,09921955 ! lung alveolus development GO:0048286 26 10 0,000 0,04357862 0,09912717 ! pathogenesis GO:0009405 17 10 0,000 0,04357862 0,09903496 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04357862 0,09894292 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04357862 0,09885105 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04357862 0,09875935 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04357862 0,09866782 ! endoderm development GO:0007492 18 10 0,000 0,04357862 0,09857646 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,04357862 0,09848527 ! arginine catabolic process GO:0006527 17 10 0,000 0,04357862 0,09839425 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,04357862 0,0983034 ! proline metabolic process GO:0006560 13 10 0,000 0,04357862 0,09821271 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,04357862 0,09812219 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,04357862 0,09803184 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,04357862 0,09794165 ! V(D)J recombination GO:0033151 34 10 0,000 0,04357862 0,09785163 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04357862 0,09776178 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04357862 0,09767209 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04357862 0,09758257 ! B cell proliferation GO:0042100 19 10 0,000 0,04357862 0,0974932 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04357862 0,09740401 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04357862 0,09731497 ! multicellular organism growth GO:0035264 19 10 0,000 0,04357862 0,0972261 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,04357862 0,09713739 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04357862 0,09704884 ! ruffle organization GO:0031529 17 10 0,000 0,04357862 0,09696045 ! epithelial cell development GO:0002064 21 10 0,000 0,04357862 0,09687223 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,04357862 0,09678416 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04357862 0,09669626 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04357862 0,09660851 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04357862 0,09652092 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,04357862 0,0964335 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04357862 0,09634623 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,04357862 0,09625911 ! motor axon guidance GO:0008045 22 10 0,000 0,04357862 0,09617216 ! copper ion homeostasis GO:0055070 13 10 0,000 0,04357862 0,09608536 ! regulation of bone resorption GO:0045124 25 10 0,000 0,04357862 0,09599872 ! protein heterooligomerization GO:0051291 17 10 0,000 0,04357862 0,09591223 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,04357862 0,0958259 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,04357862 0,09573973 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,04357862 0,09565371 ! segment specification GO:0007379 15 10 0,000 0,04357862 0,09556784 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,04357862 0,09548213 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,04357862 0,09539658 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04357862 0,09531117 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04357862 0,09522592 ! response to dsRNA GO:0043331 23 10 0,000 0,04357862 0,09514082 ! DNA ligation GO:0006266 18 10 0,000 0,04357862 0,09505587 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,04357862 0,09497108 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04357862 0,09488643 ! melanosome localization GO:0032400 16 10 0,000 0,04357862 0,09480194 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04357862 0,0947176 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,04357862 0,0946334 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,04357862 0,09454936 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,04357862 0,09446546 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,04357862 0,09438172 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04357862 0,09429812 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04357862 0,09421467 ! protein sumoylation GO:0016925 17 10 0,000 0,04357862 0,09413137 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,04357862 0,09404821 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04357862 0,09396521 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04357862 0,09388234 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04357862 0,09379963 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04357862 0,09371706 ! salivary gland development GO:0007431 28 10 0,000 0,04357862 0,09363463 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04357862 0,09355235 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,04357862 0,09347022 ! midbrain development GO:0030901 14 10 0,000 0,04357862 0,09338823 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04357862 0,09330638 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,04357862 0,09322467 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04357862 0,09314311 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,04357862 0,09306169 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04357862 0,09298042 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04357862 0,09289928 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04357862 0,09281829 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,04357862 0,09273744 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,04357862 0,09265673 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,04357862 0,09257616 ! blastocyst formation GO:0001825 18 10 0,000 0,04357862 0,09249572 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,04357862 0,09241543 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04357862 0,09233528 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04357862 0,09225527 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04357862 0,09217539 ! response to nicotine GO:0035094 20 10 0,000 0,04357862 0,09209566 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,04357862 0,09201606 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,04357862 0,0919366 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,04411364 0,09298501 GO:0090046|regulation of transcription regulator activity, ! axon guidance GO:0007411 162 75 1,000 0,04411364 0,09290485 ! rhythmic process GO:0048511 142 75 1,000 0,04411364 0,09282483 ! regulation of blood pressure GO:0008217 134 76 1,000 0,04517677 0,09498007 ! amine catabolic process GO:0009310 136 77 1,000 0,04624932 0,09715142 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,04624932 0,09706795 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,0478313 0,10030203 ! respiratory burst GO:0045730 17 11 0,000 0,0478313 0,10021601 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,0478313 0,10013013 ! neuron fate specification GO:0048665 18 11 0,000 0,0478313 0,10004441 ! telencephalon cell migration GO:0022029 23 11 0,000 0,0478313 0,09995882 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,0478313 0,09987339 ! thyroid gland development GO:0030878 26 11 0,000 0,0478313 0,0997881 ! synapsis GO:0007129 14 11 0,000 0,0478313 0,09970296 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,0478313 0,09961796 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,0478313 0,09953311 ! response to pain GO:0048265 27 11 0,000 0,0478313 0,0994484 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,0478313 0,09936383 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,0478313 0,09927941 ! blood vessel remodeling GO:0001974 30 11 0,000 0,0478313 0,09919513 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,0478313 0,099111 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,0478313 0,099027 ! bone resorption GO:0045453 16 11 0,000 0,0478313 0,09894315 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,0478313 0,09885945 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,0478313 0,09877588 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,0478313 0,09869245 ! melanocyte differentiation GO:0030318 20 11 0,000 0,0478313 0,09860917 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,0478313 0,09852602 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,0478313 0,09844302 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,0478313 0,09836016 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of intracellular pH GO:0051453 21 11 0,000 0,0478313 0,09827743 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,0478313 0,09819484 ! UV protection GO:0009650 20 11 0,000 0,0478313 0,0981124 ! adult heart development GO:0007512 16 11 0,000 0,0478313 0,09803009 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,0478313 0,09794792 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,0478313 0,09786588 ! macroautophagy GO:0016236 19 11 0,000 0,0478313 0,09778399 ! temperature homeostasis GO:0001659 18 11 0,000 0,0478313 0,09770223 ! behavioral fear response GO:0001662 27 11 0,000 0,0478313 0,09762061 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,0478313 0,09753912 ! negative regulation of ossification GO:0030279 27 11 0,000 0,0478313 0,09745777 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,0478313 0,09737655 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,0478313 0,09729548 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,0478313 0,09721453 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,0478313 0,09713372 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,0478313 0,09705304 ! regulation of organ growth GO:0046620 14 11 0,000 0,0478313 0,0969725 ! pigment granule localization GO:0051875 20 11 0,000 0,0478313 0,09689209 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,0478313 0,09681182 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,0478313 0,09673168 ! embryonic axis specification GO:0000578 19 11 0,000 0,0478313 0,09665167 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,0478313 0,09657179 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,0478313 0,09649204 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,0478313 0,09641243 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,0478313 0,09633295 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,0478313 0,0962536 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,0478313 0,09617437 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,0478313 0,09609528 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,0478313 0,09601632 ! prophase GO:0051324 17 11 0,000 0,0478313 0,09593749 ! neuroblast proliferation GO:0007405 25 11 0,000 0,0478313 0,09585879 ! nucleosome positioning GO:0016584 15 11 0,000 0,0478313 0,09578022 ! regulation of isotype switching GO:0045191 24 11 0,000 0,0478313 0,09570177 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,0478313 0,09562346 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,0478313 0,09554527 ! apical protein localization GO:0045176 18 11 0,000 0,0478313 0,09546721 ! acid secretion GO:0046717 20 11 0,000 0,0478313 0,09538928 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,0478313 0,09531147 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,0478313 0,09523379 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,0478313 0,09515624 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,0478313 0,09507882 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,0478313 0,09500152 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,0478313 0,09492434 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,0478313 0,09484729 ! cholesterol efflux GO:0033344 21 11 0,000 0,0478313 0,09477037 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,0478313 0,09469357 ! oocyte development GO:0048599 20 11 0,000 0,0478313 0,0946169 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,0478313 0,09454034 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,0478313 0,09446392 ! embryonic gut development GO:0048566 19 11 0,000 0,0478313 0,09438761 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,0478313 0,09431143 ! activation of innate immune response GO:0002218 16 11 0,000 0,0478313 0,09423538 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,0478313 0,09415944 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,0478313 0,09408363 ! lysogeny GO:0030069 22 11 0,000 0,0478313 0,09400794 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,0478313 0,09393237 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,0478313 0,09385692 ! sequestering of metal ion GO:0051238 15 11 0,000 0,0478313 0,09378159 ! regulation of embryonic development GO:0045995 35 11 0,000 0,0478313 0,09370639 ! nucleus localization GO:0051647 22 11 0,000 0,0478313 0,0936313 ! protein oligomerization GO:0051259 149 79 1,000 0,04842234 0,09471239 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,04952259 0,09678694 ! meiosis GO:0007126 143 81 1,000 0,05063186 0,09887581 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,05063186 0,09879684 ! response to hypoxia GO:0001666 178 81 1,000 0,05063186 0,09871799 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,05175006 0,1008177 ! protein import into nucleus GO:0006606 174 82 1,000 0,05175006 0,10073737 ! meiotic cell cycle GO:0051321 144 82 1,000 0,05175006 0,10065717 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,05206519 0,10118954 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,05206519 0,1011091 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,05206519 0,10102879 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,05206519 0,10094861 ! virus-host interaction GO:0019048 30 12 0,000 0,05206519 0,10086856 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,05206519 0,10078863 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,05206519 0,10070883 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,05206519 0,10062915 ! protein complex disassembly GO:0043241 28 12 0,000 0,05206519 0,1005496 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05206519 0,10047018 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,05206519 0,10039088 ! hippocampus development GO:0021766 29 12 0,000 0,05206519 0,10031171 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,05206519 0,10023266 ! T cell proliferation GO:0042098 32 12 0,000 0,05206519 0,10015374 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05206519 0,10007494 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,05206519 0,09999626 ! ventral spinal cord development GO:0021517 25 12 0,000 0,05206519 0,09991771 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,05206519 0,09983928 ! drug transport GO:0015893 16 12 0,000 0,05206519 0,09976098 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,05206519 0,0996828 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,05206519 0,09960474 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,05206519 0,0995268 ! polyamine metabolic process GO:0006595 18 12 0,000 0,05206519 0,09944898 ! focal adhesion formation GO:0048041 37 12 0,000 0,05206519 0,09937129 ! mitotic spindle organization GO:0007052 23 12 0,000 0,05206519 0,09929371 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,05206519 0,09921626 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,05206519 0,09913893 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,05206519 0,09906172 ! lipid digestion GO:0044241 21 12 0,000 0,05206519 0,09898463 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,05206519 0,09890766 ! entry into host cell GO:0030260 34 12 0,000 0,05206519 0,09883081 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05206519 0,09875407 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,05206519 0,09867746 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,05206519 0,09860097 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05206519 0,09852459 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,05206519 0,09844833 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,05206519 0,09837219 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,05206519 0,09829617 ! snRNA metabolic process GO:0016073 30 12 0,000 0,05206519 0,09822027 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,05206519 0,09814448 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,05206519 0,09806881 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05206519 0,09799326 ! cranial nerve development GO:0021545 23 12 0,000 0,05206519 0,09791782 ! fucose catabolic process GO:0019317 25 12 0,000 0,05206519 0,0978425 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,05206519 0,09776729 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,05206519 0,0976922 ! autonomic nervous system development GO:0048483 24 12 0,000 0,05206519 0,09761723 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,05206519 0,09754237 ! zymogen activation GO:0031638 18 12 0,000 0,05206519 0,09746762 ! T cell homeostasis GO:0043029 28 12 0,000 0,05206519 0,09739299 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,05206519 0,09731848 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,05206519 0,09724407 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,05206519 0,09716978 ! oocyte differentiation GO:0009994 21 12 0,000 0,05206519 0,09709561 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,05206519 0,09702155 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,05206519 0,0969476 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,05206519 0,09687376 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,05206519 0,09680004 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,05206519 0,09672642 ! defense response to fungus GO:0050832 15 12 0,000 0,05206519 0,09665292 ! embryonic placenta development GO:0001892 21 12 0,000 0,05206519 0,09657954 ! lamellipodium assembly GO:0030032 24 12 0,000 0,05206519 0,09650626 ! response to cold GO:0009409 17 12 0,000 0,05206519 0,09643309 ! establishment of cell polarity GO:0030010 21 12 0,000 0,05206519 0,09636004 ! regulation of synapse organization GO:0050807 18 12 0,000 0,05206519 0,09628709 ! response to drug GO:0042493 149 83 1,000 0,05287709 0,09771462 ! response to oxygen levels GO:0070482 183 83 1,000 0,05287709 0,09764076 ! nuclear import GO:0051170 177 83 1,000 0,05287709 0,09756701 ! response to nutrient GO:0007584 135 84 1,000 0,05401284 0,09958745 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,05628036 0,10368999 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05628036 0,10361185 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,05628036 0,10353383 ! regulation of chemokine production GO:0032642 18 13 0,000 0,05628036 0,10345593 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05628036 0,10337814 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,05628036 0,10330047 ! peroxisomal transport GO:0043574 28 13 0,000 0,05628036 0,10322292 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,05628036 0,10314548 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,05628036 0,10306816 ! organelle fusion GO:0048284 36 13 0,000 0,05628036 0,10299096 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,05628036 0,10291387 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,05628036 0,10283689 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,05628036 0,10276004 ! endocrine pancreas development GO:0031018 25 13 0,000 0,05628036 0,10268329 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,05628036 0,10260666 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,05628036 0,10253015 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,05628036 0,10245375 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,05628036 0,10237746 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,05628036 0,10230129 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,05628036 0,10222522 ! methionine metabolic process GO:0006555 31 13 0,000 0,05628036 0,10214928 ! plasma membrane organization GO:0007009 27 13 0,000 0,05628036 0,10207344 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,05628036 0,10199772 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,05628036 0,10192211 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,05628036 0,10184661 ! response to X-ray GO:0010165 28 13 0,000 0,05628036 0,10177123 ! cytokine metabolic process GO:0042107 24 13 0,000 0,05628036 0,10169595 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,05628036 0,10162079 ! exocrine system development GO:0035272 34 13 0,000 0,05628036 0,10154574 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,05628036 0,1014708 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,05628036 0,10139596 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,05628036 0,10132124 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,05628036 0,10124663 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,05628036 0,10117213 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,05628036 0,10109774 ! protein homotetramerization GO:0051289 24 13 0,000 0,05628036 0,10102346 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,05628036 0,10094929 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,05628036 0,10087522 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,05628036 0,10080127 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,05628036 0,10072742 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05628036 0,10065368 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,05628036 0,10058005 ! histone methylation GO:0016571 29 13 0,000 0,05628036 0,10050653 ! chromatin silencing GO:0006342 29 13 0,000 0,05628036 0,10043311 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,05628036 0,1003598 ! regulation of epidermis development GO:0045682 19 13 0,000 0,05628036 0,1002866 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,05628036 0,1002135 ! spleen development GO:0048536 24 13 0,000 0,05628036 0,10014052 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,05628036 0,10006763 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,05628036 0,09999486 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,05628036 0,09992219 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,05628036 0,09984962 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05628036 0,09977716 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,05628036 0,09970481 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,05628036 0,09963256 ! insulin secretion GO:0030073 24 13 0,000 0,05628036 0,09956041 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,05628036 0,09948837 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,05628036 0,09941643 ! acrosome reaction GO:0007340 19 13 0,000 0,05628036 0,0993446 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,05628036 0,09927287 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,05628036 0,09920125 ! amine biosynthetic process GO:0009309 146 88 1,000 0,05864114 0,10328789 ! regulation of DNA binding GO:0051101 167 89 1,000 0,05981905 0,1052867 ! protein localization in nucleus GO:0034504 192 89 1,000 0,05981905 0,1052109 ! rRNA transcription GO:0009303 28 14 0,000 0,06047692 0,10629144 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06047692 0,10621503 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,06047692 0,10613872 ! water transport GO:0006833 21 14 0,000 0,06047692 0,10606253 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06047692 0,10598645 ! non-recombinational repair GO:0000726 29 14 0,000 0,06047692 0,10591047 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,06047692 0,1058346 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06047692 0,10575884 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,06047692 0,10568319 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06047692 0,10560765 ! lipid localization GO:0010876 32 14 0,000 0,06047692 0,10553222 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,06047692 0,10545689 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06047692 0,10538167 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06047692 0,10530656 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06047692 0,10523156 ! arginine metabolic process GO:0006525 21 14 0,000 0,06047692 0,10515666 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06047692 0,10508187 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06047692 0,10500718 ! regulation of heart rate GO:0002027 25 14 0,000 0,06047692 0,1049326 ! fear response GO:0042596 34 14 0,000 0,06047692 0,10485813 ! organic alcohol transport GO:0015850 29 14 0,000 0,06047692 0,10478376 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06047692 0,1047095 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,06047692 0,10463534 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,06047692 0,10456129 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06047692 0,10448734 ! bone mineralization GO:0030282 18 14 0,000 0,06047692 0,1044135 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06047692 0,10433976 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06047692 0,10426613 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06047692 0,1041926 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,06047692 0,10411917 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06047692 0,10404585 ! regulation of cellular pH GO:0030641 27 14 0,000 0,06047692 0,10397263 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,06047692 0,10389951 ! ribosome assembly GO:0042255 18 14 0,000 0,06047692 0,1038265 ! cerebellum development GO:0021549 23 14 0,000 0,06047692 0,10375358 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06047692 0,10368078 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,06047692 0,10360807 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06047692 0,10353546 ! response to gamma radiation GO:0010332 30 14 0,000 0,06047692 0,10346296 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06047692 0,10339056 ! NADP metabolic process GO:0006739 24 14 0,000 0,06047692 0,10331826 ! oxygen transport GO:0015671 22 14 0,000 0,06047692 0,10324606 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,06047692 0,10317396 ! male genitalia development GO:0030539 26 14 0,000 0,06047692 0,10310196 ! regulation of RNA stability GO:0043487 33 14 0,000 0,06047692 0,10303006 ! regulation of axon extension GO:0030516 43 14 0,000 0,06047692 0,10295826 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,06047692 0,10288656 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,06047692 0,10281497 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,06047692 0,10274347 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,06100511 0,10356879 ! ossification GO:0001503 205 91 1,000 0,06219922 0,1055227 ! gland development GO:0048732 220 91 1,000 0,06219922 0,10544947 ! bone development GO:0060348 206 92 1,000 0,06340128 0,10741284 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,06340128 0,10733841 ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,0646112 0,10931105 ! vitamin metabolic process GO:0006766 153 93 1,000 0,0646112 0,10923541 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,06465492 0,10923373 ! lactation GO:0007595 30 15 0,000 0,06465492 0,10915824 ! reproductive cellular process GO:0048610 22 15 0,000 0,06465492 0,10908286 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06465492 0,10900758 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,06465492 0,1089324 ! superoxide anion generation GO:0042554 22 15 0,000 0,06465492 0,10885733 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,06465492 0,10878236 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,06465492 0,10870749 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,06465492 0,10863272 ! copper ion transport GO:0006825 22 15 0,000 0,06465492 0,10855806 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,06465492 0,1084835 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,06465492 0,10840905 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,06465492 0,10833469 ! sulfate transport GO:0008272 27 15 0,000 0,06465492 0,10826044 ! response to cAMP GO:0051591 25 15 0,000 0,06465492 0,10818629 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,06465492 0,10811224 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,06465492 0,10803829 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,06465492 0,10796444 ! response to hexose stimulus GO:0009746 25 15 0,000 0,06465492 0,1078907 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,06465492 0,10781705 ! vesicle coating GO:0006901 38 15 0,000 0,06465492 0,10774351 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,06465492 0,10767006 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,06465492 0,10759672 ! regulation of exocytosis GO:0017157 26 15 0,000 0,06465492 0,10752347 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,06465492 0,10745033 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,06465492 0,10737728 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,06465492 0,10730433 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,06465492 0,10723149 ! regulation of vasodilation GO:0042312 27 15 0,000 0,06465492 0,10715874 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,06465492 0,10708609 ! histone deacetylation GO:0016575 24 15 0,000 0,06465492 0,10701354 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,06465492 0,10694108 ! water homeostasis GO:0030104 28 15 0,000 0,06465492 0,10686873 ! cofactor transport GO:0051181 30 15 0,000 0,06465492 0,10679647 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06465492 0,10672431 ! muscle maintenance GO:0046716 26 15 0,000 0,06465492 0,10665225 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,06465492 0,10658028 ! intestinal absorption GO:0050892 31 15 0,000 0,06465492 0,10650842 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06465492 0,10643664 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,06465492 0,10636497 ! heme biosynthetic process GO:0006783 33 15 0,000 0,06465492 0,10629339 ! cell killing GO:0001906 32 15 0,000 0,06465492 0,10622191 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,06465492 0,10615052 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,06465492 0,10607923 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,06465492 0,10600804 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,06465492 0,10593694 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,06465492 0,10586594 ! actin filament polymerization GO:0030041 27 15 0,000 0,06465492 0,10579503 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,06465492 0,10572422 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,06582889 0,1075719 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,06582889 0,10749999 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,06881447 0,11230044 ! positive regulation of cell size GO:0045793 29 16 0,000 0,06881447 0,11222547 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,06881447 0,1121506 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,06881447 0,11207583 ! bone remodeling GO:0046849 28 16 0,000 0,06881447 0,11200117 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,06881447 0,1119266 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,06881447 0,11185213 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06881447 0,11177776 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,06881447 0,11170349 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,06881447 0,11162932 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,06881447 0,11155524 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,06881447 0,11148127 ! startle response GO:0001964 28 16 0,000 0,06881447 0,11140739 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,06881447 0,11133361 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,06881447 0,11125993 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,06881447 0,11118634 ! protein polyubiquitination GO:0000209 41 16 0,000 0,06881447 0,11111286 ! glutamate metabolic process GO:0006536 25 16 0,000 0,06881447 0,11103947 ! pituitary gland development GO:0021983 30 16 0,000 0,06881447 0,11096617 ! response to osmotic stress GO:0006970 27 16 0,000 0,06881447 0,11089298 ! lysosomal transport GO:0007041 31 16 0,000 0,06881447 0,11081988 ! fructose metabolic process GO:0006000 25 16 0,000 0,06881447 0,11074687 ! L-amino acid transport GO:0015807 33 16 0,000 0,06881447 0,11067396 ! stem cell development GO:0048864 46 16 0,000 0,06881447 0,11060115 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,06881447 0,11052844 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,06881447 0,11045582 ! negative regulation of immune response GO:0050777 38 16 0,000 0,06881447 0,11038329 ! axon cargo transport GO:0008088 46 16 0,000 0,06881447 0,11031086 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,06881447 0,11023853 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,06881447 0,11016629 ! DNA replication initiation GO:0006270 28 16 0,000 0,06881447 0,11009414 ! neuron recognition GO:0008038 40 16 0,000 0,06881447 0,11002209 ! mRNA splice site selection GO:0006376 44 16 0,000 0,06881447 0,10995013 ! tissue regeneration GO:0042246 27 16 0,000 0,06881447 0,10987827 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,06881447 0,1098065 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,06881447 0,10973482 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,06881447 0,10966324 ! biomineral formation GO:0031214 22 16 0,000 0,06881447 0,10959175 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,06881447 0,10952036 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,06881447 0,10944906 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,06881447 0,10937785 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,06881447 0,10930673 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,06881447 0,10923571 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,06881447 0,10916477 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,06881447 0,10909393 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,06881447 0,10902319 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,06881447 0,10895253 ! peptide hormone processing GO:0016486 27 16 0,000 0,06881447 0,10888196 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,06952767 0,10993922 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,07295564 0,11528501 ! metencephalon development GO:0022037 32 17 0,000 0,07295564 0,11521048 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,07295564 0,11513606 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,07295564 0,11506173 ! signal complex assembly GO:0007172 47 17 0,000 0,07295564 0,1149875 ! filopodium assembly GO:0046847 42 17 0,000 0,07295564 0,11491336 ! endothelial cell migration GO:0043542 31 17 0,000 0,07295564 0,11483932 ! gene silencing by RNA GO:0031047 38 17 0,000 0,07295564 0,11476537 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,07295564 0,11469152 ! glial cell development GO:0021782 28 17 0,000 0,07295564 0,11461776 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,07295564 0,1145441 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,07295564 0,11447053 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,07295564 0,11439706 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,07295564 0,11432368 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,07295564 0,1142504 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,07295564 0,11417721 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,07295564 0,11410411 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,07295564 0,11403111 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,07295564 0,1139582 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,07295564 0,11388538 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,07295564 0,11381266 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,07295564 0,11374002 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,07295564 0,11366749 GO:0031114|regulation of microtubule depolymerization, ! membrane budding GO:0006900 42 17 0,000 0,07295564 0,11359504 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,07295564 0,11352269 ! regulation of protein binding GO:0043393 33 17 0,000 0,07295564 0,11345043 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,07295564 0,11337826 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,07295564 0,11330618 ! genitalia development GO:0048806 32 17 0,000 0,07295564 0,11323419 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,07295564 0,1131623 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,07295564 0,11309049 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,07295564 0,11301878 GO:0002712|regulation of B cell mediated immunity, ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,07295564 0,11294716 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,07295564 0,11287563 ! steroid catabolic process GO:0006706 34 17 0,000 0,07295564 0,11280419 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,07295564 0,11273284 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,07295564 0,11266158 ! gas transport GO:0015669 26 17 0,000 0,07295564 0,11259041 ! organic cation transport GO:0015695 32 17 0,000 0,07295564 0,11251933 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,07295564 0,11244834 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,07295564 0,11237744 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,07295564 0,11230663 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,0770785 0,11857857 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,0770785 0,11850395 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,0770785 0,11842942 ! limbic system development GO:0021761 40 18 0,000 0,0770785 0,11835498 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0770785 0,11828064 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,0770785 0,11820639 ! adult walking behavior GO:0007628 36 18 0,000 0,0770785 0,11813223 ! patterning of blood vessels GO:0001569 43 18 0,000 0,0770785 0,11805817 ! heart looping GO:0001947 34 18 0,000 0,0770785 0,1179842 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,0770785 0,11791032 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,0770785 0,11783653 ! centrosome cycle GO:0007098 26 18 0,000 0,0770785 0,11776284 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,0770785 0,11768924 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,0770785 0,11761573 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,0770785 0,11754231 ! glycine metabolic process GO:0006544 30 18 0,000 0,0770785 0,11746898 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0770785 0,11739575 ! response to retinoic acid GO:0032526 31 18 0,000 0,0770785 0,1173226 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,0770785 0,11724955 ! DNA integration GO:0015074 32 18 0,000 0,0770785 0,11717659 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,0770785 0,11710372 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,0770785 0,11703094 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,0770785 0,11695825 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,0770785 0,11688565 ! neural crest cell migration GO:0001755 41 18 0,000 0,0770785 0,11681314 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,0770785 0,11674072 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,0770785 0,11666839 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,0770785 0,11659615 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,0770785 0,116524 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,0770785 0,11645193 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,0770785 0,11637996 ! detection of bacterium GO:0016045 22 18 0,000 0,0770785 0,11630808 ! nerve development GO:0021675 34 18 0,000 0,0770785 0,11623628 ! defense response to virus GO:0051607 43 18 0,000 0,0770785 0,11616458 ! microspike assembly GO:0030035 46 18 0,000 0,0770785 0,11609296 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,0770785 0,11602143 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,0770785 0,11594999 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,08118314 0,12204949 ! positive regulation of translation GO:0045727 31 19 0,000 0,08118314 0,12197443 ! negative regulation of defense response GO:0031348 27 19 0,000 0,08118314 0,12189946 ! neuron maturation GO:0042551 46 19 0,000 0,08118314 0,12182458 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,08118314 0,1217498 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,08118314 0,12167511 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,08118314 0,1216005 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,08118314 0,12152599 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,08118314 0,12145158 ! inositol metabolic process GO:0006020 33 19 0,000 0,08118314 0,12137725 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,08118314 0,12130301 ! memory GO:0007613 34 19 0,000 0,08118314 0,12122886 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,08118314 0,12115481 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,08118314 0,12108084 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,08118314 0,12100697 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,08118314 0,12093318 ! cerebral cortex development GO:0021987 40 19 0,000 0,08118314 0,12085949 ! pigmentation during development GO:0048066 42 19 0,000 0,08118314 0,12078588 ! response to vitamin A GO:0033189 32 19 0,000 0,08118314 0,12071237 ! heme metabolic process GO:0042168 40 19 0,000 0,08118314 0,12063894 ! neuromuscular junction development GO:0007528 43 19 0,000 0,08118314 0,12056561 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,08118314 0,12049236 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,08118314 0,1204192 ! response to fungus GO:0009620 26 19 0,000 0,08118314 0,12034613 ! peptide cross-linking GO:0018149 39 19 0,000 0,08118314 0,12027315 ! protein export from nucleus GO:0006611 40 19 0,000 0,08118314 0,12020026 ! heart process GO:0003015 32 19 0,000 0,08118314 0,12012745 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,08118314 0,12005474 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,08118314 0,11998211 ! visual learning GO:0008542 38 19 0,000 0,08118314 0,11990957 ! cellular pigmentation GO:0033059 37 19 0,000 0,08118314 0,11983711 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,08118314 0,11976475 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,08118314 0,11969247 ! vitamin transport GO:0051180 31 19 0,000 0,08118314 0,11962028 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,08118314 0,11954818 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,08118314 0,11947616 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,08118314 0,11940423 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,08118314 0,11933238 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,08118314 0,11926063 ! cilium assembly GO:0042384 38 19 0,000 0,08118314 0,11918896 ! peptide hormone secretion GO:0030072 32 19 0,000 0,08118314 0,11911737 ! protein secretion GO:0009306 45 20 0,000 0,08526965 0,12503827 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,08526965 0,12496326 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,08526965 0,12488834 ! positive regulation of ossification GO:0045778 50 20 0,000 0,08526965 0,12481351 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,08526965 0,12473877 ! skin development GO:0043588 42 20 0,000 0,08526965 0,12466412 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,08526965 0,12458956 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,08526965 0,12451509 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,08526965 0,12444071 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,08526965 0,12436642 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,08526965 0,12429222 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,08526965 0,1242181 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,08526965 0,12414407 ! bile acid metabolic process GO:0008206 34 20 0,000 0,08526965 0,12407013 ! response to alkaloid GO:0043279 38 20 0,000 0,08526965 0,12399628 ! retinoid metabolic process GO:0001523 34 20 0,000 0,08526965 0,12392252 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,08526965 0,12384884 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,08526965 0,12377525 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,08526965 0,12370175 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,08526965 0,12362834 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,08526965 0,12355501 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,08526965 0,12348177 ! body fluid secretion GO:0007589 33 20 0,000 0,08526965 0,12340862 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,08526965 0,12333555 ! peptide secretion GO:0002790 38 20 0,000 0,08526965 0,12326258 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,08526965 0,12318968 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,08526965 0,12311687 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,08526965 0,12304415 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,08526965 0,12297152 ! cell-cell junction organization GO:0045216 43 20 0,000 0,08526965 0,12289897 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,08526965 0,1228265 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,08526965 0,12275413 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,08526965 0,12268183 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,08526965 0,12260962 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,08526965 0,1225375 ! regulation of glucose import GO:0046324 30 20 0,000 0,08526965 0,12246546 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,08526965 0,12239351 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,08526965 0,12232164 ! negative regulation of translation GO:0017148 32 20 0,000 0,08526965 0,12224985 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,08526965 0,12217815 ! regulation of cell killing GO:0031341 46 21 0,000 0,08933809 0,12793257 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,08933809 0,12785762 ! hormone secretion GO:0046879 39 21 0,000 0,08933809 0,12778276 ! lipid phosphorylation GO:0046834 43 21 0,000 0,08933809 0,12770799 ! cAMP metabolic process GO:0046058 41 21 0,000 0,08933809 0,12763331 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,08933809 0,12755871 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,08933809 0,12748421 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,08933809 0,12740978 ! ovarian follicle development GO:0001541 39 21 0,000 0,08933809 0,12733545 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,08933809 0,1272612 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,08933809 0,12718704 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,08933809 0,12711296 ! plasma membrane fusion GO:0045026 33 21 0,000 0,08933809 0,12703898 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,08933809 0,12696507 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,08933809 0,12689126 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,08933809 0,12681752 ! sensory perception of pain GO:0019233 33 21 0,000 0,08933809 0,12674388 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,08933809 0,12667032 ! diencephalon development GO:0021536 36 21 0,000 0,08933809 0,12659684 ! collagen fibril organization GO:0030199 62 21 0,000 0,08933809 0,12652346 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,08933809 0,12645015 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,08933809 0,12637693 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,08933809 0,1263038 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,08933809 0,12623075 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,08933809 0,12615778 ! collagen catabolic process GO:0030574 29 21 0,000 0,08933809 0,1260849 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,08933809 0,1260121 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,08933809 0,12593939 ! sperm-egg recognition GO:0035036 23 21 0,000 0,08933809 0,12586676 ! actin filament-based movement GO:0030048 47 21 0,000 0,08933809 0,12579421 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,08933809 0,12572175 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,09338856 0,13134614 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,09338856 0,13127056 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,09338856 0,13119508 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,09338856 0,13111968 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,09338856 0,13104437 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,09338856 0,13096914 ! microtubule-based transport GO:0010970 59 22 0,000 0,09338856 0,130894 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,09338856 0,13081895 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,09338856 0,13074398 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,09338856 0,1306691 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,09338856 0,1305943 ! cellular response to starvation GO:0009267 37 22 0,000 0,09338856 0,13051959 ! vacuolar transport GO:0007034 41 22 0,000 0,09338856 0,13044496 ! central nervous system neuron development GO:0021954 47 22 0,000 0,09338856 0,13037042 ! fucose metabolic process GO:0006004 44 22 0,000 0,09338856 0,13029597 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,09338856 0,1302216 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,09338856 0,13014731 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,09338856 0,13007311 ! ureteric bud development GO:0001657 50 22 0,000 0,09338856 0,129999 ! cell aging GO:0007569 48 22 0,000 0,09338856 0,12992497 ! stem cell differentiation GO:0048863 57 22 0,000 0,09338856 0,12985102 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,09338856 0,12977716 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,09338856 0,12970338 ! cytolysis GO:0019835 27 22 0,000 0,09338856 0,12962968 ! renal system process GO:0003014 42 22 0,000 0,09338856 0,12955607 ! vasodilation GO:0042311 40 22 0,000 0,09338856 0,12948254 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,09338856 0,1294091 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,09338856 0,12933574 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,09338856 0,12926246 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,09338856 0,12918926 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,09338856 0,12911615 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,09338856 0,12904312 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,09338856 0,12897018 ! sarcomere organization GO:0045214 32 22 0,000 0,09338856 0,12889731 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,09338856 0,12882453 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,09338856 0,12875183 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,09338856 0,12867921 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,09338856 0,12860667 ! gut development GO:0048565 44 22 0,000 0,09338856 0,12853422 ! protein stabilization GO:0050821 41 22 0,000 0,09338856 0,12846185 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,09742112 0,13393348 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,09742112 0,13385815 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,09742112 0,1337829 ! glycerol metabolic process GO:0006071 40 23 0,000 0,09742112 0,13370774 ! viral genome replication GO:0019079 44 23 0,000 0,09742112 0,13363267 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,09742112 0,13355768 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,09742112 0,13348277 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,09742112 0,13340795 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,09742112 0,13333321 ! regeneration GO:0031099 42 23 0,000 0,09742112 0,13325856 ! axis specification GO:0009798 43 23 0,000 0,09742112 0,13318399 ! visual behavior GO:0007632 46 23 0,000 0,09742112 0,1331095 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,09742112 0,1330351 ! response to ethanol GO:0045471 47 23 0,000 0,09742112 0,13296077 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,09742112 0,13288654 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,09742112 0,13281238 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,09742112 0,13273831 ! peroxisome organization GO:0007031 43 23 0,000 0,09742112 0,13266432 ! lysosome organization GO:0007040 47 23 0,000 0,09742112 0,13259041 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,09742112 0,13251658 ! vesicle targeting GO:0006903 49 23 0,000 0,09742112 0,13244284 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,09742112 0,13236918 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,09742112 0,1322956 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,09742112 0,1322221 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,09742112 0,13214869 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,09742112 0,13207535 ! DNA modification GO:0006304 36 23 0,000 0,09742112 0,1320021 ! fatty acid transport GO:0015908 47 23 0,000 0,09742112 0,13192893 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,09742112 0,13185584 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,09742112 0,13178283 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,09742112 0,1317099 ! hormone transport GO:0009914 41 23 0,000 0,09742112 0,13163705 ! cell-cell recognition GO:0009988 28 23 0,000 0,09742112 0,13156428 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,09742112 0,13149159 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,09742112 0,13141899 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,09742112 0,13134646 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,10143585 0,13668383 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,10143585 0,13660848 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,10143585 0,13653322 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,10143585 0,13645803 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,10143585 0,13638293 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,10143585 0,13630791 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,10143585 0,13623298 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,10143585 0,13615812 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,10143585 0,13608335 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,10143585 0,13600866 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,10143585 0,13593406 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,10143585 0,13585953 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,10143585 0,13578509 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,10143585 0,13571073 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,10143585 0,13563645 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,10143585 0,13556225 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,10143585 0,13548813 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,10143585 0,13541409 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,10143585 0,13534014 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,10143585 0,13526626 ! membrane depolarization GO:0051899 45 24 0,000 0,10143585 0,13519246 ! pallium development GO:0021543 56 24 0,000 0,10143585 0,13511875 ! oogenesis GO:0048477 44 24 0,000 0,10143585 0,13504512 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,10143585 0,13497156 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,10143585 0,13489809 ! platelet activation GO:0030168 41 24 0,000 0,10143585 0,13482469 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,10143585 0,13475138 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,10143585 0,13467815 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,10143585 0,13460499 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,10143585 0,13453191 ! regulation of amine transport GO:0051952 41 24 0,000 0,10143585 0,13445892 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,10143585 0,134386 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,10543284 0,13960566 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,10543284 0,13953003 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,10543284 0,13945449 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,10543284 0,13937902 ! leukocyte adhesion GO:0007159 55 25 0,000 0,10543284 0,13930364 ! phototransduction GO:0007602 37 25 0,000 0,10543284 0,13922834 ! keratinization GO:0031424 37 25 0,000 0,10543284 0,13915313 ! vasculogenesis GO:0001570 49 25 0,000 0,10543284 0,13907799 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,10543284 0,13900293 ! vacuole organization GO:0007033 49 25 0,000 0,10543284 0,13892796 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,10543284 0,13885307 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,10543284 0,13877825 ! receptor metabolic process GO:0043112 53 25 0,000 0,10543284 0,13870352 ! chromosome condensation GO:0030261 48 25 0,000 0,10543284 0,13862887 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,10543284 0,1385543 ! regulation of behavior GO:0050795 48 25 0,000 0,10543284 0,1384798 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,10543284 0,13840539 ! interaction with host GO:0051701 66 25 0,000 0,10543284 0,13833106 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,10543284 0,13825681 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,10543284 0,13818264 ! immunoglobulin production GO:0002377 62 25 0,000 0,10543284 0,13810855 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,10543284 0,13803453 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,10543284 0,1379606 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,10543284 0,13788674 ! liver development GO:0001889 55 25 0,000 0,10543284 0,13781297 ! protein tetramerization GO:0051262 57 25 0,000 0,10543284 0,13773927 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,10941217 0,14286153 ! myelination GO:0042552 50 26 0,000 0,10941217 0,14278522 ! initiation of viral infection GO:0019059 60 26 0,000 0,10941217 0,14270898 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,10941217 0,14263283 ! molting cycle process GO:0022404 52 26 0,000 0,10941217 0,14255676 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,10941217 0,14248077 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,10941217 0,14240486 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,10941217 0,14232903 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,10941217 0,14225329 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,10941217 0,14217762 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,10941217 0,14210203 ! digestive system process GO:0022600 49 26 0,000 0,10941217 0,14202653 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,10941217 0,1419511 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,10941217 0,14187576 ! osteoblast differentiation GO:0001649 63 26 0,000 0,10941217 0,14180049 ! neural crest cell development GO:0014032 59 26 0,000 0,10941217 0,14172531 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,10941217 0,1416502 ! negative regulation of cell development GO:0010721 83 26 0,000 0,10941217 0,14157517 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,10941217 0,14150023 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,10941217 0,14142536 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,10941217 0,14135057 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,10941217 0,14127586 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,10941217 0,14120123 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,10941217 0,14112668 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,10941217 0,1410522 ! blastocyst development GO:0001824 50 26 0,000 0,10941217 0,14097781 ! telomere organization GO:0032200 46 26 0,000 0,10941217 0,14090349 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 58 26 0,000 0,10941217 0,14082925 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,10941217 0,1407551 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,10941217 0,14068101 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,10941217 0,14060701 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,1133739 0,14562168 ! embryonic pattern specification GO:0009880 49 27 0,000 0,1133739 0,14554516 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,1133739 0,14546872 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,1133739 0,14539236 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,1133739 0,14531608 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,1133739 0,14523988 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,1133739 0,14516375 ! iron ion transport GO:0006826 65 27 0,000 0,1133739 0,14508771 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,1133739 0,14501175 ! superoxide metabolic process GO:0006801 41 27 0,000 0,1133739 0,14493587 ! tube lumen formation GO:0035148 59 27 0,000 0,1133739 0,14486006 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,1133739 0,14478434 ! insulin receptor signaling pathway GO:0008286 66 27 0,000 0,1133739 0,1447087 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,1133739 0,14463313 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,1133739 0,14455764 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,1133739 0,14448223 ! response to starvation GO:0042594 47 27 0,000 0,1133739 0,1444069 ! response to toxin GO:0009636 49 27 0,000 0,1133739 0,14433165 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,1133739 0,14425648 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,1133739 0,14418139 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,1133739 0,14410637 ! leukocyte proliferation GO:0070661 59 27 0,000 0,1133739 0,14403143 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,1133739 0,14395657 ! neuron fate commitment GO:0048663 52 28 0,000 0,11731812 0,14888736 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,11731812 0,14881006 ! vesicle docking GO:0048278 55 28 0,000 0,11731812 0,14873284 ! dendrite development GO:0016358 67 28 0,000 0,11731812 0,14865569 ! fat cell differentiation GO:0045444 57 28 0,000 0,11731812 0,14857863 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,11731812 0,14850165 ! sperm motility GO:0030317 37 28 0,000 0,11731812 0,14842474 ! base-excision repair GO:0006284 41 28 0,000 0,11731812 0,14834792 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,11731812 0,14827117 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,11731812 0,14819451 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,11731812 0,14811792 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,11731812 0,14804141 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,11731812 0,14796499 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,11731812 0,14788864 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,11731812 0,14781237 ! glutathione metabolic process GO:0006749 42 28 0,000 0,11731812 0,14773617 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,11731812 0,14766006 ! lipid oxidation GO:0034440 48 28 0,000 0,11731812 0,14758402 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,11731812 0,14750807 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,11731812 0,14743219 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,12124491 0,15228859 ! translational initiation GO:0006413 66 29 0,000 0,12124491 0,15221034 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,12124491 0,15213216 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,12124491 0,15205406 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,12124491 0,15197605 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,12124491 0,15189811 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,12124491 0,15182025 ! primary neural tube formation GO:0014020 61 29 0,000 0,12124491 0,15174248 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,12124491 0,15166478 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,12124491 0,15158716 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,12124491 0,15150962 ! synaptogenesis GO:0007416 46 29 0,000 0,12124491 0,15143217 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,12124491 0,15135479 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,12124491 0,15127748 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,12124491 0,15120026 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,12124491 0,15112312 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,12515434 0,15591639 ! phenol metabolic process GO:0018958 56 30 0,000 0,12515434 0,15583692 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,12515434 0,15575754 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,12515434 0,15567823 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,12515434 0,15559901 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,12515434 0,15551986 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,12515434 0,1554408 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,12515434 0,15536181 ! acute-phase response GO:0006953 50 30 0,000 0,12515434 0,15528291 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,12515434 0,15520408 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,12515434 0,15512534 ! myofibril assembly GO:0030239 50 30 0,000 0,12515434 0,15504668 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,12515434 0,15496809 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,12515434 0,15488959 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,12515434 0,15481116 ! cell fate determination GO:0001709 64 30 0,000 0,12515434 0,15473282 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,12515434 0,15465455 ! phospholipid transport GO:0015914 65 30 0,000 0,12515434 0,15457636 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,12515434 0,15449825 ! neurotransmitter secretion GO:0007269 55 30 0,000 0,12515434 0,15442022 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,12515434 0,15434227 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,12515434 0,1542644 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,12515434 0,15418661 ! regulation of coagulation GO:0050818 52 30 0,000 0,12515434 0,15410889 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,12904648 0,15882144 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,12904648 0,15874147 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,12904648 0,15866158 ! cell junction assembly GO:0034329 85 31 0,000 0,12904648 0,15858177 ! regulation of innate immune response GO:0045088 57 31 0,000 0,12904648 0,15850204 ! ovulation cycle process GO:0022602 55 31 0,000 0,12904648 0,15842239 ! peptide transport GO:0015833 60 31 0,000 0,12904648 0,15834282 ! male gonad development GO:0008584 56 31 0,000 0,12904648 0,15826333 ! iron ion homeostasis GO:0055072 60 31 0,000 0,12904648 0,15818392 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,12904648 0,15810459 ! detection of light stimulus GO:0009583 44 31 0,000 0,12904648 0,15802534 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,12904648 0,15794617 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,12904648 0,15786708 ! natural killer cell activation GO:0030101 50 31 0,000 0,12904648 0,15778807 ! ensheathment of neurons GO:0007272 64 31 0,000 0,12904648 0,15770913 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,12904648 0,15763028 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,12904648 0,1575515 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,12904648 0,1574728 ! eye morphogenesis GO:0048592 65 31 0,000 0,12904648 0,15739419 ! response to heat GO:0009408 54 31 0,000 0,12904648 0,15731565 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,12904648 0,15723718 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,13292142 0,16187788 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,13292142 0,16179722 ! collagen metabolic process GO:0032963 49 32 0,000 0,13292142 0,16171665 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,13292142 0,16163615 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,13292142 0,16155573 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,13292142 0,1614754 ! metanephros development GO:0001656 81 32 0,000 0,13292142 0,16139514 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,13292142 0,16131497 ! muscle cell development GO:0055001 52 32 0,000 0,13292142 0,16123487 ! mesoderm formation GO:0001707 73 32 0,000 0,13292142 0,16115485 ! ovulation cycle GO:0042698 57 32 0,000 0,13292142 0,16107491 ! peripheral nervous system development GO:0007422 68 32 0,000 0,13292142 0,16099506 ! BMP signaling pathway GO:0030509 71 32 0,000 0,13292142 0,16091528 ! hindbrain development GO:0030902 65 32 0,000 0,13292142 0,16083558 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,13292142 0,16075595 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,13292142 0,16067641 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,13292142 0,16059695 ! gene silencing GO:0016458 71 32 0,000 0,13292142 0,16051756 ! regulation of pH GO:0006885 56 33 0,000 0,13677923 0,16509469 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,13677923 0,16501316 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,13677923 0,16493171 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,13677923 0,16485034 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,13677923 0,16476906 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,13677923 0,16468785 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,13677923 0,16460672 ! response to ionizing radiation GO:0010212 74 33 0,000 0,13677923 0,16452568 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,13677923 0,16444471 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,13677923 0,16436382 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,13677923 0,16428301 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,13677923 0,16420228 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,13677923 0,16412163 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,14061998 0,16864732 ! glial cell differentiation GO:0010001 67 34 0,000 0,14061998 0,16856457 ! post-embryonic development GO:0009791 76 34 0,000 0,14061998 0,1684819 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,14061998 0,16839931 ! cholesterol transport GO:0030301 62 34 0,000 0,14061998 0,16831681 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,14061998 0,16823438 ! spliceosome assembly GO:0000245 75 34 0,000 0,14061998 0,16815203 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,14061998 0,16806977 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,14061998 0,16798758 ! formation of primary germ layer GO:0001704 76 34 0,000 0,14061998 0,16790547 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,14061998 0,16782345 ! adult locomotory behavior GO:0008344 62 34 0,000 0,14061998 0,1677415 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,14061998 0,16765964 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,14444374 0,17213467 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,14444374 0,17205074 ! negative regulation of secretion GO:0051048 68 35 0,000 0,14444374 0,17196689 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,14444374 0,17188313 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,14444374 0,17179945 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,14444374 0,17171585 ! membrane docking GO:0022406 69 35 0,000 0,14444374 0,17163233 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,14444374 0,17154889 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,14444374 0,17146553 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,14444374 0,17138226 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,14444374 0,17129906 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,14444374 0,17121595 ! ceramide metabolic process GO:0006672 72 35 0,000 0,14444374 0,17113291 ! telencephalon development GO:0021537 81 35 0,000 0,14444374 0,17104996 ! sterol transport GO:0015918 63 35 0,000 0,14444374 0,17096709 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,14444374 0,17088429 ! placenta development GO:0001890 53 35 0,000 0,14444374 0,17080158 ! vesicle localization GO:0051648 70 35 0,000 0,14444374 0,17071895 ! regulation of muscle development GO:0048634 82 36 0,000 0,14825061 0,17513358 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,14825061 0,17504893 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,14825061 0,17496436 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,14825061 0,17487988 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,14825061 0,17479548 ! positive regulation of cell development GO:0010720 85 36 0,000 0,14825061 0,17471116 ! protein targeting to membrane GO:0006612 75 36 0,000 0,14825061 0,17462692 ! regulation of proteolysis GO:0030162 77 36 0,000 0,14825061 0,17454276 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,14825061 0,17445869 ! aerobic respiration GO:0009060 56 36 0,000 0,14825061 0,17437469 ! cytokine production GO:0001816 68 36 0,000 0,14825061 0,17429078 ! embryonic organ development GO:0048568 67 36 0,000 0,14825061 0,17420694 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,15204064 0,17857465 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,15204064 0,17848884 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,15204064 0,17840311 ! odontogenesis GO:0042476 74 37 0,000 0,15204064 0,17831746 ! actomyosin structure organization GO:0031032 68 37 0,000 0,15204064 0,1782319 ! cell junction organization GO:0034330 96 37 0,000 0,15204064 0,17814642 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,15204064 0,17806102 ! female gonad development GO:0008585 71 37 0,000 0,15204064 0,1779757 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,15204064 0,17789046 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,15204064 0,1778053 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,15204064 0,17772023 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,15204064 0,17763524 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,15581391 0,18195668 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,15581391 0,18186975 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,15581391 0,1817829 ! organic anion transport GO:0015711 82 38 0,000 0,15581391 0,18169613 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,15581391 0,18160944 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,15581391 0,18152283 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,15581391 0,18143631 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,15581391 0,18134987 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,15581391 0,18126352 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,15581391 0,18117724 ! regulation of protein stability GO:0031647 77 38 0,000 0,15581391 0,18109105 ! spermatid development GO:0007286 69 38 0,000 0,15581391 0,18100494 ! pigment metabolic process GO:0042440 87 38 0,000 0,15581391 0,18091891 ! cellular response to insulin stimulus GO:0032869 85 38 0,000 0,15581391 0,18083296 ! neural tube formation GO:0001841 79 38 0,000 0,15581391 0,1807471 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,1595705 0,18501696 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,1595705 0,18492919 ! negative regulation of binding GO:0051100 71 39 0,000 0,1595705 0,1848415 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,1595705 0,1847539 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,1595705 0,18466638 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,1595705 0,18457894 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,1595705 0,18449159 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,1595705 0,18440432 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,1595705 0,18431713 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,1595705 0,18423002 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,1595705 0,184143 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,16331047 0,18836992 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,16331047 0,18828102 ! learning GO:0007612 82 40 0,000 0,16331047 0,18819221 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,16331047 0,18810348 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,16331047 0,18801484 ! lipid homeostasis GO:0055088 75 40 0,000 0,16331047 0,18792628 ! mismatch repair GO:0006298 58 40 0,000 0,16331047 0,1878378 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,16331047 0,18774941 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,16331047 0,1876611 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,16331047 0,18757287 ! RNA export from nucleus GO:0006405 61 41 0,000 0,16703391 0,19175933 ! mRNA catabolic process GO:0006402 79 41 0,000 0,16703391 0,19166926 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,16703391 0,19157927 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,16703391 0,19148937 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,16703391 0,19139955 ! feeding behavior GO:0007631 69 41 0,000 0,16703391 0,19130982 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,16703391 0,19122017 ! mesenchymal cell development GO:0014031 94 41 0,000 0,16703391 0,19113061 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,16703391 0,19104113 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,16703391 0,19095173 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,16703391 0,19086242 ! spermatid differentiation GO:0048515 73 41 0,000 0,16703391 0,19077319 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,16703391 0,19068404 ! RNA modification GO:0009451 64 41 0,000 0,16703391 0,19059498 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,17074088 0,19473388 ! ear morphogenesis GO:0042471 64 42 0,000 0,17074088 0,19464302 ! organic ether metabolic process GO:0018904 59 42 0,000 0,17074088 0,19455223 ! T cell differentiation GO:0030217 93 42 0,000 0,17074088 0,19446153 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,17074088 0,19437091 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,17074088 0,19428038 ! regulation of protein secretion GO:0050708 77 42 0,000 0,17074088 0,19418994 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,17074088 0,19409957 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,17443146 0,19820282 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,17443146 0,19811068 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,17443146 0,19801862 ! glucose transport GO:0015758 66 43 0,000 0,17443146 0,19792664 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,17443146 0,19783476 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,17443146 0,19774295 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,17443146 0,19765124 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,17443146 0,1975596 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,17443146 0,19746806 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,17443146 0,19737659 ! ion transmembrane transport GO:0034220 79 43 0,000 0,17443146 0,19728522 ! neuron migration GO:0001764 85 43 0,000 0,17443146 0,19719392 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,17810572 0,20125452 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,17810572 0,20116148 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,17810572 0,20106852 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,17810572 0,20097565 ! hexose transport GO:0008645 68 44 0,000 0,17810572 0,20088286 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 0,000 0,17810572 0,20079016 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,17810572 0,20069755 ! double-strand break repair GO:0006302 85 44 0,000 0,17810572 0,20060502 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,18176373 0,20463078 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,18176373 0,20453652 ! induction of apoptosis by intracellular signals GO:0008629 95 45 0,000 0,18176373 0,20444235 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,18176373 0,20434827 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,18176373 0,20425427 ! biopolymer methylation GO:0043414 91 45 0,000 0,18176373 0,20416036 ! B cell differentiation GO:0030183 124 45 0,000 0,18176373 0,20406654 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,18176373 0,2039728 ! female gamete generation GO:0007292 71 45 0,000 0,18176373 0,20387915 ! polyol metabolic process GO:0019751 77 45 0,000 0,18176373 0,20378559 ! developmental growth GO:0048589 88 45 0,000 0,18176373 0,20369211 ! maintenance of location in cell GO:0051651 101 45 0,000 0,18176373 0,20359871 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,18540556 0,20758285 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,18540556 0,20748776 ! glycolysis GO:0006096 71 46 0,000 0,18540556 0,20739276 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,18540556 0,20729784 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,18540556 0,20720301 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,18540556 0,20710827 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,18540556 0,20701361 ! pigmentation GO:0043473 103 46 0,000 0,18540556 0,20691904 ! neural tube development GO:0021915 91 47 0,000 0,18903128 0,21086914 ! response to insulin stimulus GO:0032868 98 47 0,000 0,18903128 0,2107729 ! positive regulation of defense response GO:0031349 88 48 0,000 0,19264097 0,21469977 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,19264097 0,21460187 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,19264097 0,21450405 ! cellular component disassembly GO:0022411 89 48 0,000 0,19264097 0,21440633 ! endosome transport GO:0016197 127 48 0,000 0,19264097 0,21430869 ! male sex differentiation GO:0046661 93 48 0,000 0,19264097 0,21421115 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,19264097 0,21411369 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,19264097 0,21401632 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,19264097 0,21391904 ! methylation GO:0032259 97 48 0,000 0,19264097 0,21382185 ! response to calcium ion GO:0051592 94 49 0,000 0,19623469 0,21771179 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,19623469 0,21761296 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,19623469 0,21751422 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,19623469 0,21741558 ! JNK cascade GO:0007254 106 49 0,000 0,19623469 0,21731702 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,19623469 0,21721856 ! regulation of action potential GO:0001508 102 50 0,000 0,19981252 0,22107879 ! regulation of ion transport GO:0043269 86 50 0,000 0,19981252 0,22097871 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,19981252 0,22087872 ! endocrine system development GO:0035270 109 50 0,000 0,19981252 0,22077882 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,19981252 0,22067901 ! activation of caspase activity GO:0006919 95 50 0,000 0,19981252 0,22057929 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,19981252 0,22047967 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,19981252 0,22038013 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,19981252 0,22028068 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,19981252 0,22018132 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,19981252 0,22008205 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,20337452 0,22390444 ! viral infectious cycle GO:0019058 104 51 0,000 0,20337452 0,22380358 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,20337452 0,22370281 ! peptide metabolic process GO:0006518 80 51 0,000 0,20337452 0,22360214 ! response to temperature stimulus GO:0009266 84 51 0,000 0,20337452 0,22350155 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,20337452 0,22340105 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,20337452 0,22330065 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,20692076 0,22709228 ! Notch signaling pathway GO:0007219 111 52 0,000 0,20692076 0,22699031 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,20692076 0,22688843 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,20692076 0,22678664 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,20692076 0,22668494 ! excretion GO:0007588 87 52 0,000 0,20692076 0,22658333 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,20692076 0,22648182 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,20692076 0,22638039 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,20692076 0,22627906 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,20692076 0,22617782 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,21045132 0,22993406 ! positive regulation of growth GO:0045927 96 53 0,000 0,21045132 0,22983128 ! chromatin remodeling GO:0006338 122 53 0,000 0,21045132 0,22972858 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,21045132 0,22962598 ! vesicle organization GO:0016050 127 53 0,000 0,21045132 0,22952347 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,21045132 0,22942105 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,21045132 0,22931872 ! synapse organization GO:0050808 102 53 0,000 0,21045132 0,22921648 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,21396626 0,23294098 ! regulation of translational initiation GO:0006446 87 54 0,000 0,21396626 0,23283722 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,21396626 0,23273355 ! neuromuscular process GO:0050905 107 54 0,000 0,21396626 0,23262998 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,21396626 0,2325265 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,21396626 0,23242311 ! membrane fusion GO:0006944 122 54 0,000 0,21396626 0,23231981 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,21396626 0,2322166 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,21396626 0,23211348 ! regulation of cell shape GO:0008360 142 54 0,000 0,21396626 0,23201046 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,21396626 0,23190753 ! RNA catabolic process GO:0006401 103 55 0,000 0,21746565 0,23559582 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,21746565 0,23549139 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,21746565 0,23538705 ! cell recognition GO:0008037 98 55 0,000 0,21746565 0,2352828 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,21746565 0,23517865 ! cell maturation GO:0048469 107 55 0,000 0,21746565 0,23507459 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,21746565 0,23497062 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,21746565 0,23486674 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,22094955 0,23852398 ! glucose catabolic process GO:0006007 88 56 0,000 0,22094955 0,23841862 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,22094955 0,23831336 ! regulation of DNA replication GO:0006275 105 56 0,000 0,22094955 0,23820819 ! RNA elongation GO:0006354 90 56 0,000 0,22094955 0,23810311 ! chloride transport GO:0006821 102 57 0,000 0,22441805 0,24173426 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,22441805 0,24162772 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 105 57 0,000 0,22441805 0,24152128 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,22441805 0,24141493 ! regulation of actin filament length GO:0030832 118 58 0,000 0,2278712 0,24502172 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,2278712 0,24491392 ! aging GO:0007568 112 58 0,000 0,2278712 0,24480622 ! gastrulation GO:0007369 122 58 0,000 0,2278712 0,24469861 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,2278712 0,2445911 ! maintenance of location GO:0051235 124 58 0,000 0,2278712 0,24448368 ! nuclear export GO:0051168 110 59 0,000 0,23130907 0,24806324 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,23473173 0,25162336 ! lipid modification GO:0030258 112 60 0,000 0,23473173 0,25151299 ! DNA catabolic process GO:0006308 94 60 0,000 0,23473173 0,25140273 ! regulation of endocytosis GO:0030100 104 60 0,000 0,23473173 0,25129256 ! adult behavior GO:0030534 104 60 0,000 0,23473173 0,25118249 ! kidney development GO:0001822 133 60 0,000 0,23473173 0,25107252 ! positive regulation of secretion GO:0051047 110 61 0,000 0,23813925 0,25460578 ! regulation of cellular component size GO:0032535 125 61 0,000 0,23813925 0,2544944 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,23813925 0,25438312 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,23813925 0,25427194 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,23813925 0,25416085 ! regulation of heart contraction GO:0008016 123 61 0,000 0,23813925 0,25404987 ! camera-type eye development GO:0043010 126 61 0,000 0,23813925 0,25393898 ! proton transport GO:0015992 117 61 0,000 0,23813925 0,25382818 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,23813925 0,25371749 ! viral reproductive process GO:0022415 132 62 0,000 0,24153169 0,25721967 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,24153169 0,25710759 ! tRNA processing GO:0008033 102 62 0,000 0,24153169 0,25699561 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,24490913 0,26047584 ! mesoderm development GO:0007498 128 63 0,000 0,24490913 0,26036249 ! hydrogen transport GO:0006818 121 64 0,000 0,24827161 0,26382233 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,24827161 0,26370763 ! response to peptide hormone stimulus GO:0043434 129 64 0,000 0,24827161 0,26359302 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,25161922 0,26703117 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,25161922 0,26691522 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,25161922 0,26679937 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,25161922 0,26668362 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,25161922 0,26656797 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,25495201 0,26998169 ! gonad development GO:0008406 115 66 0,000 0,25495201 0,26986472 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,25495201 0,26974784 ! negative regulation of cell growth GO:0030308 142 67 0,000 0,25827006 0,27314015 ! activation of MAPK activity GO:0000187 124 67 0,000 0,25827006 0,27302196 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,25827006 0,27290387 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,25827006 0,27278588 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,25827006 0,272668 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,26157342 0,27603622 ! hexose catabolic process GO:0019320 113 68 0,000 0,26157342 0,27591704 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,26157342 0,27579795 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,26157342 0,27567897 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,26157342 0,27556009 ! viral reproduction GO:0016032 142 68 0,000 0,26157342 0,27544132 ! adaptive immune response GO:0002250 126 68 0,000 0,26157342 0,27532264 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,26157342 0,27520407 ! negative regulation of cell size GO:0045792 144 69 0,000 0,26486216 0,27854423 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,26486216 0,27842438 ! negative regulation of protein kinase activity GO:0006469 144 69 0,000 0,26486216 0,27830462 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,26486216 0,27818497 ! urogenital system development GO:0001655 149 69 0,000 0,26486216 0,27806543 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,26486216 0,27794598 ! developmental maturation GO:0021700 128 69 0,000 0,26486216 0,27782664 ! single fertilization GO:0007338 83 69 0,000 0,26486216 0,2777074 ! negative regulation of kinase activity GO:0033673 145 70 0,000 0,26813634 0,28101977 ! cell redox homeostasis GO:0045454 114 70 0,000 0,26813634 0,28089927 ! germ cell development GO:0007281 133 70 0,000 0,26813634 0,28077886 ! activation of immune response GO:0002253 120 70 0,000 0,26813634 0,28065856 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,26813634 0,28053837 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,27139604 0,28382728 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,27139604 0,28370583 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,27139604 0,28358449 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,27139604 0,28346324 ! appendage morphogenesis GO:0035107 150 72 0,000 0,27464131 0,28673022 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,27464131 0,28660774 ! actin filament organization GO:0007015 167 72 0,000 0,27464131 0,28648536 ! B cell activation GO:0042113 179 72 0,000 0,27464131 0,28636309 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,27464131 0,28624092 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,27464131 0,28611886 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,27464131 0,2859969 ! appendage development GO:0048736 151 73 0,000 0,27787221 0,2892381 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,27787221 0,28911492 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,27787221 0,28899184 ! regulation of immune effector process GO:0002697 156 73 0,000 0,27787221 0,28886886 ! acute inflammatory response GO:0002526 118 74 0,000 0,28108882 0,29208847 ! amino acid transport GO:0006865 148 74 0,000 0,28108882 0,29196428 ! negative regulation of transferase activity GO:0051348 155 74 0,000 0,28108882 0,2918402 ! transition metal ion transport GO:0000041 143 75 0,000 0,28429119 0,29503966 ! reproductive structure development GO:0048608 131 75 0,000 0,28429119 0,29491438 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,28429119 0,29478921 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,28429119 0,29466414 ! eye development GO:0001654 155 75 0,000 0,28429119 0,29453917 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,28747938 0,29771603 ! learning or memory GO:0007611 161 76 0,000 0,28747938 0,29758988 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,28747938 0,29746384 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,28747938 0,2973379 ! neurotransmitter transport GO:0006836 142 77 0,000 0,29065346 0,30049361 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,29065346 0,3003665 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,29065346 0,30023949 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,29065346 0,3001126 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,29065346 0,29998581 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,29065346 0,29985912 ! regulation of catabolic process GO:0009894 173 77 0,000 0,29065346 0,29973255 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,29381349 0,30286344 ! antigen processing and presentation GO:0019882 117 78 0,000 0,29381349 0,3027357 ! fertilization GO:0009566 99 78 0,000 0,29381349 0,30260807 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,29381349 0,30248055 ! blood coagulation GO:0007596 151 79 0,000 0,29695953 0,30559062 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,29695953 0,30546195 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,29695953 0,30533339 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,29695953 0,30520493 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,29695953 0,30507659 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,29695953 0,30494835 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,30009164 0,30803524 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,30009164 0,30790587 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,30009164 0,30777661 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,30320989 0,31084421 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,30940503 0,31706228 ! exocytosis GO:0006887 153 83 0,000 0,30940503 0,31692934 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,30940503 0,31679652 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,30940503 0,3166638 ! inorganic anion transport GO:0015698 156 83 0,000 0,30940503 0,31653119 ! response to metal ion GO:0010038 158 84 0,000 0,31248204 0,31954526 ! T cell activation GO:0042110 189 84 0,000 0,31248204 0,31941156 ! digestion GO:0007586 130 84 0,000 0,31248204 0,31927797 ! regulation of ligase activity GO:0051340 147 84 0,000 0,31248204 0,3191445 ! hemostasis GO:0007599 165 85 0,000 0,31554543 0,32213853 ! negative regulation of transport GO:0051051 164 85 0,000 0,31554543 0,32200397 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,31554543 0,32186952 ! negative regulation of growth GO:0045926 168 85 0,000 0,31554543 0,32173518 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,31554543 0,32160096 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,31554543 0,32146685 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,31554543 0,32133285 ! cellular response to hormone stimulus GO:0032870 182 85 0,000 0,31554543 0,32119896 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,31859526 0,32416836 ! regulation of lyase activity GO:0051339 169 86 0,000 0,31859526 0,3240334 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,31859526 0,32389855 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,32163158 0,3268494 ! mitochondrion organization GO:0007005 159 87 0,000 0,32163158 0,3267135 ! alcohol catabolic process GO:0046164 142 87 0,000 0,32163158 0,32657771 ! nucleosome assembly GO:0006334 126 87 0,000 0,32163158 0,32644203 ! cellular respiration GO:0045333 143 88 0,000 0,32465446 0,32937328 ! sensory perception of smell GO:0007608 117 88 0,000 0,32465446 0,32923655 ! chromatin assembly GO:0031497 128 88 0,000 0,32465446 0,32909994 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,32465446 0,32896344 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,32766396 0,33187523 ! tube morphogenesis GO:0035239 194 89 0,000 0,32766396 0,33173769 ! cellular defense response GO:0006968 123 89 0,000 0,32766396 0,33160027 ! regulation of neurological system process GO:0031644 175 89 0,000 0,32766396 0,33146296 ! response to inorganic substance GO:0010035 173 90 0,000 0,33066012 0,33435541 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,33066012 0,33421708 ! response to unfolded protein GO:0006986 139 90 0,000 0,33066012 0,33407886 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,33364302 0,33695325 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,33364302 0,33681401 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,33661271 0,33967156 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,33956925 0,34251349 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,33956925 0,34237213 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,33956925 0,34223089 ! female pregnancy GO:0007565 166 94 0,000 0,3425127 0,34505506 ! sterol metabolic process GO:0016125 166 94 0,000 0,3425127 0,34491283 ! regulation of membrane potential GO:0042391 179 94 0,000 0,3425127 0,34477071 ! regulation of defense response GO:0031347 171 95 0,000 0,3454431 0,34757723 ! nucleosome organization GO:0034728 143 95 0,000 0,3454431 0,34743413 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,3454431 0,34729115 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,3454431 0,34714829 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,3454431 0,34700555 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,3454431 0,34686293 ! sex differentiation GO:0007548 171 96 0,000 0,34836053 0,34964864 ! response to protein stimulus GO:0051789 158 96 0,000 0,34836053 0,34950505 ! regulation of T cell activation GO:0050863 175 96 0,000 0,34836053 0,34936157 ! regulation of DNA metabolic process GO:0051052 188 97 0,000 0,35126504 0,35212987 ! transcription initiation GO:0006352 171 97 0,000 0,35126504 0,35198544 ! leukocyte differentiation GO:0002521 232 98 0,000 0,35415669 0,35473751 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,35415669 0,35459213 ! mRNA transport GO:0051028 185 100 0,000 0,35990161 0,36019649 ! positive regulation of immune response GO:0050778 175 100 0,000 0,35990161 0,36004899 ! hormone metabolic process GO:0042445 171 100 0,000 0,35990161 0,35990161