pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1130-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! epithelial to mesenchymal transition GO:0001837 22 14 4,000 3,427E-09 7,881E-06 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 7,019E-08 8,072E-05 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 4,434E-07 3,399E-04 ! mesenchymal cell development GO:0014031 64 38 4,000 7,884E-07 4,533E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! response to insulin stimulus GO:0032868 63 43 4,000 1,485E-06 6,832E-04 ! positive regulation of ossification GO:0045778 30 19 3,000 1,495E-06 5,733E-04 ! ER overload response GO:0006983 7 6 2,000 1,827E-06 6,004E-04 ! salivary gland morphogenesis GO:0007435 11 6 2,000 1,827E-06 5,254E-04 ! positive regulation of bone remodeling GO:0046852 33 21 3,000 2,293E-06 5,86E-04 GO:0034105|positive regulation of tissue remodeling, ! response to endoplasmic reticulum stress GO:0034976 25 21 3,000 2,293E-06 5,274E-04 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 2,49E-06 5,207E-04 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 2,793E-06 5,353E-04 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 2,000 3,187E-06 5,639E-04 ! ER-nuclear signaling pathway GO:0006984 27 23 3,000 3,369E-06 5,535E-04 ! positive regulation of cell migration GO:0030335 92 51 4,000 3,522E-06 5,401E-04 ! positive regulation of B cell proliferation GO:0030890 11 8 2,000 5,083E-06 7,307E-04 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 2,000 5,083E-06 6,877E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 5,083E-06 6,495E-04 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 2,000 5,083E-06 6,153E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 5,083E-06 5,845E-04 ! positive regulation of cell motion GO:0051272 99 56 4,000 5,626E-06 6,162E-04 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 6,145E-06 6,424E-04 ! SMAD protein nuclear translocation GO:0007184 15 9 2,000 7,599E-06 7,599E-04 ! regulation of B cell proliferation GO:0030888 15 10 2,000 1,082E-05 1,037E-03 ! salivary gland development GO:0007431 22 10 2,000 1,082E-05 9,955E-04 ! mammary gland development GO:0030879 57 31 3,000 1,164E-05 1,03E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 4,000 1,696E-05 1,444E-03 ! gland morphogenesis GO:0022612 23 12 2,000 1,971E-05 1,619E-03 ! tube morphogenesis GO:0035239 118 73 4,000 2,082E-05 1,651E-03 ! protein import into nucleus GO:0006606 118 74 4,000 2,225E-05 1,706E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 2,225E-05 1,651E-03 ! negative regulation of growth GO:0045926 123 75 4,000 2,375E-05 1,707E-03 ! nuclear import GO:0051170 121 75 4,000 2,375E-05 1,656E-03 ! exocrine system development GO:0035272 27 13 2,000 2,553E-05 1,727E-03 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 2,553E-05 1,678E-03 ! gland development GO:0048732 148 77 4,000 2,7E-05 1,725E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 3,239E-05 2,013E-03 GO:0060675|ureteric bud morphogenesis, ! positive regulation of biomineral formation GO:0070169 20 14 2,000 3,239E-05 1,96E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 3,239E-05 1,91E-03 ! protein localization in nucleus GO:0034504 133 80 4,000 3,25E-05 1,869E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 3,278E-05 1,839E-03 ! branching morphogenesis of a tube GO:0048754 72 42 3,000 3,987E-05 2,183E-03 ! dopamine metabolic process GO:0042417 30 15 2,000 4,035E-05 2,159E-03 ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 4,035E-05 2,109E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 4,356E-05 2,227E-03 ! regulation of gene-specific transcription GO:0032583 69 43 3,000 4,381E-05 2,19E-03 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 4,381E-05 2,144E-03 ! cell cycle arrest GO:0007050 150 86 4,000 4,609E-05 2,208E-03 ! negative regulation of immune response GO:0050777 28 16 2,000 4,95E-05 2,324E-03 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 2,000 4,95E-05 2,277E-03 ! regulation of ossification GO:0030278 71 46 3,000 5,732E-05 2,585E-03 ! response to UV GO:0009411 75 46 3,000 5,732E-05 2,535E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 5,991E-05 2,6E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 6,708E-05 2,857E-03 ! heart morphogenesis GO:0003007 65 48 3,000 6,788E-05 2,839E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 6,788E-05 2,788E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 7,166E-05 2,892E-03 ! morphogenesis of a branching structure GO:0001763 86 49 3,000 7,366E-05 2,921E-03 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 8,481E-05 3,306E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 8,481E-05 3,251E-03 ! protein import GO:0017038 156 99 4,000 9,036E-05 3,407E-03 ! protein localization in organelle GO:0033365 161 100 4,000 9,478E-05 3,516E-03 ! positive regulation of B cell activation GO:0050871 31 20 2,000 9,945E-05 3,631E-03 ! regulation of bone remodeling GO:0046850 90 53 3,000 1,004E-04 3,608E-03 ! skeletal system morphogenesis GO:0048705 78 53 3,000 1,004E-04 3,552E-03 ! regulation of tissue remodeling GO:0034103 91 54 3,000 1,081E-04 3,765E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,156E-04 3,97E-03 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 2,000 1,156E-04 3,912E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 1,156E-04 3,855E-03 ! regulation of bone mineralization GO:0030500 29 21 2,000 1,156E-04 3,8E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 1,335E-04 4,324E-03 ! ureteric bud development GO:0001657 32 22 2,000 1,335E-04 4,263E-03 ! protein tetramerization GO:0051262 39 22 2,000 1,335E-04 4,205E-03 ! activation of MAPK activity GO:0000187 84 59 3,000 1,528E-04 4,75E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 1,53E-04 4,691E-03 ! regulation of biomineral formation GO:0070167 31 23 2,000 1,53E-04 4,63E-03 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 1,53E-04 4,57E-03 ! regulation of alpha-beta T cell activation GO:0046634 35 24 2,000 1,743E-04 5,138E-03 ! negative regulation of cell growth GO:0030308 106 62 3,000 1,854E-04 5,397E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 1,974E-04 5,674E-03 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of MAPKKK cascade GO:0043410 36 25 2,000 1,974E-04 5,604E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 1,974E-04 5,536E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 2,05E-04 5,68E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 2,05E-04 5,612E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,05E-04 5,546E-03 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 2,05E-04 5,482E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 2,05E-04 5,419E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 2,05E-04 5,357E-03 ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 2,05E-04 5,297E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of multicellular organism growth GO:0040015 7 5 1,000 2,05E-04 5,238E-03 ! muscle cell proliferation GO:0033002 8 5 1,000 2,05E-04 5,18E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 2,05E-04 5,124E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,05E-04 5,069E-03 ! regulation of hair follicle development GO:0051797 9 5 1,000 2,05E-04 5,015E-03 GO:0042634|regulation of hair cycle, ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 1,000 2,05E-04 4,962E-03 ! glial cell migration GO:0008347 10 5 1,000 2,05E-04 4,911E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 2,05E-04 4,86E-03 GO:0051930|regulation of sensory perception of pain, ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 2,05E-04 4,81E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of cell size GO:0045792 108 64 3,000 2,097E-04 4,872E-03 ! regulation of caspase activity GO:0043281 97 65 3,000 2,227E-04 5,121E-03 ! protein oligomerization GO:0051259 100 65 3,000 2,227E-04 5,071E-03 ! catechol metabolic process GO:0009712 43 27 2,000 2,494E-04 5,623E-03 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of endopeptidase activity GO:0052548 99 67 3,000 2,503E-04 5,59E-03 ! phenol metabolic process GO:0018958 44 28 2,000 2,784E-04 6,156E-03 ! positive regulation of T cell differentiation GO:0045582 39 28 2,000 2,784E-04 6,097E-03 ! regulation of B cell activation GO:0050864 42 28 2,000 2,784E-04 6,04E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 3,065E-04 6,589E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 3,065E-04 6,528E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,065E-04 6,468E-03 ! thymic T cell selection GO:0045061 12 6 1,000 3,065E-04 6,409E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 3,065E-04 6,352E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 3,065E-04 6,295E-03 ! male sex determination GO:0030238 9 6 1,000 3,065E-04 6,239E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 3,065E-04 6,184E-03 GO:0043011|myeloid dendritic cell differentiation, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 3,065E-04 6,131E-03 ! regulation of peptidase activity GO:0052547 106 72 3,000 3,303E-04 6,548E-03 ! response to hypoxia GO:0001666 132 72 3,000 3,303E-04 6,492E-03 ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 3,427E-04 6,68E-03 ! response to oxygen levels GO:0070482 137 74 3,000 3,668E-04 7,09E-03 ! positive regulation of lymphocyte activation GO:0051251 108 74 3,000 3,668E-04 7,031E-03 ! DNA damage checkpoint GO:0000077 53 31 2,000 3,782E-04 7,188E-03 ! metanephros development GO:0001656 58 31 2,000 3,782E-04 7,13E-03 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 2,000 4,159E-04 7,777E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 4,279E-04 7,936E-03 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 4,279E-04 7,873E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 4,279E-04 7,81E-03 ! positive regulation of isotype switching GO:0045830 15 7 1,000 4,279E-04 7,749E-03 GO:0045911|positive regulation of DNA recombination, ! protein heterooligomerization GO:0051291 10 7 1,000 4,279E-04 7,688E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 4,279E-04 7,629E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 4,279E-04 7,57E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 4,279E-04 7,512E-03 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 4,279E-04 7,455E-03 GO:0002714|positive regulation of B cell mediated immunity, ! response to tumor cell GO:0002347 12 7 1,000 4,279E-04 7,399E-03 ! positive regulation of epidermis development GO:0045684 11 7 1,000 4,279E-04 7,344E-03 ! dopamine biosynthetic process GO:0042416 15 7 1,000 4,279E-04 7,29E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 4,279E-04 7,236E-03 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 4,279E-04 7,183E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 4,279E-04 7,131E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 4,56E-04 7,546E-03 ! positive regulation of cell development GO:0010720 54 33 2,000 4,56E-04 7,492E-03 ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 4,56E-04 7,439E-03 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 4,985E-04 8,074E-03 ! DNA integrity checkpoint GO:0031570 57 34 2,000 4,985E-04 8,018E-03 ! positive regulation of cell activation GO:0050867 120 81 3,000 5,177E-04 8,269E-03 GO:0002696|positive regulation of leukocyte activation, ! regulation of intracellular protein transport GO:0033157 59 35 2,000 5,434E-04 8,62E-03 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 5,434E-04 8,561E-03 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 5,688E-04 8,9E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 5,688E-04 8,839E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 5,688E-04 8,78E-03 ! keratinocyte proliferation GO:0043616 12 8 1,000 5,688E-04 8,722E-03 ! middle ear morphogenesis GO:0042474 9 8 1,000 5,688E-04 8,664E-03 ! regulation of smoothened signaling pathway GO:0008589 13 8 1,000 5,688E-04 8,607E-03 ! regulation of gliogenesis GO:0014013 20 8 1,000 5,688E-04 8,551E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of telomere maintenance GO:0032204 10 8 1,000 5,688E-04 8,495E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 5,688E-04 8,44E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 6,495E-04 9,576E-03 ! pigmentation GO:0043473 74 38 2,000 6,936E-04 0,01016074 ! interphase GO:0051325 159 88 3,000 7,083E-04 0,01031046 ! regulation of developmental growth GO:0048638 13 9 1,000 7,291E-04 0,01054738 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 7,291E-04 0,01048146 ! regulation of glycolysis GO:0006110 15 9 1,000 7,291E-04 0,01041636 ! T cell selection GO:0045058 18 9 1,000 7,291E-04 0,01035206 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 7,291E-04 0,01028855 GO:0002820|negative regulation of adaptive immune response, ! thymus development GO:0048538 15 9 1,000 7,291E-04 0,01022582 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 7,291E-04 0,01016384 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 2,000 7,489E-04 0,0103765 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 7,489E-04 0,01031436 ! cell growth GO:0016049 61 39 2,000 7,489E-04 0,01025297 ! leukocyte differentiation GO:0002521 143 90 3,000 7,708E-04 0,0104897 ! T cell differentiation GO:0030217 65 40 2,000 8,07E-04 0,01091793 ! positive regulation of protein transport GO:0051222 55 40 2,000 8,07E-04 0,01085408 ! regulation of T cell differentiation GO:0045580 59 41 2,000 8,678E-04 0,01160468 ! regulation of phosphatase activity GO:0010921 21 10 1,000 9,087E-04 0,01208133 ! regulation of cell projection assembly GO:0060491 20 10 1,000 9,087E-04 0,0120119 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 9,087E-04 0,01194326 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 9,087E-04 0,0118754 ! response to X-ray GO:0010165 16 10 1,000 9,087E-04 0,01180831 ! DNA methylation GO:0006306 15 10 1,000 9,087E-04 0,01174197 GO:0006305|DNA alkylation, ! protein sumoylation GO:0016925 12 10 1,000 9,087E-04 0,01167637 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 9,087E-04 0,01161151 GO:0043470|regulation of carbohydrate catabolic process, ! cardiac cell differentiation GO:0035051 16 10 1,000 9,087E-04 0,01154735 ! T cell receptor signaling pathway GO:0050852 18 10 1,000 9,087E-04 0,01148391 ! negative regulation of immune effector process GO:0002698 16 10 1,000 9,087E-04 0,01142115 ! hair follicle morphogenesis GO:0031069 17 10 1,000 9,087E-04 0,01135908 ! positive regulation of heart contraction GO:0045823 14 10 1,000 9,087E-04 0,01129768 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 9,087E-04 0,01123694 ! regulation of B cell differentiation GO:0045577 16 10 1,000 9,087E-04 0,01117685 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 9,315E-04 0,01139622 ! embryonic skeletal system development GO:0048706 56 42 2,000 9,315E-04 0,01133593 ! in utero embryonic development GO:0001701 147 96 3,000 9,815E-04 0,01188149 ! response to light stimulus GO:0009416 153 96 3,000 9,815E-04 0,01181928 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 9,981E-04 0,01195636 ! activation of caspase activity GO:0006919 65 43 2,000 9,981E-04 0,01189441 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 1,068E-03 0,01265728 ! virus-host interaction GO:0019048 17 11 1,000 1,107E-03 0,01306129 ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,107E-03 0,01299465 ! T cell proliferation GO:0042098 20 11 1,000 1,107E-03 0,01292869 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 1,107E-03 0,01286339 ! focal adhesion formation GO:0048041 24 11 1,000 1,107E-03 0,01279875 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,107E-03 0,01273476 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 1,107E-03 0,0126714 ! T cell homeostasis GO:0043029 20 11 1,000 1,107E-03 0,01260867 ! regulation of isotype switching GO:0045191 19 11 1,000 1,107E-03 0,01254656 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,14E-03 0,0128543 ! homophilic cell adhesion GO:0007156 149 100 3,000 1,143E-03 0,01282046 ! negative regulation of immune system process GO:0002683 73 47 2,000 1,294E-03 0,01445085 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 1,294E-03 0,01438104 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 1,294E-03 0,0143119 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,325E-03 0,01458027 ! palate development GO:0060021 15 12 1,000 1,325E-03 0,01451084 ! positive regulation of cell growth GO:0030307 16 12 1,000 1,325E-03 0,01444207 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,325E-03 0,01437395 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,325E-03 0,01430647 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,325E-03 0,01423961 ! response to gamma radiation GO:0010332 20 12 1,000 1,325E-03 0,01417338 ! regulation of epidermis development GO:0045682 17 12 1,000 1,325E-03 0,01410777 ! positive regulation of caspase activity GO:0043280 72 48 2,000 1,376E-03 0,01458491 GO:0010952|positive regulation of peptidase activity, ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 1,376E-03 0,014518 ! regulation of intracellular transport GO:0032386 78 49 2,000 1,461E-03 0,01534376 ! positive regulation of growth GO:0045927 67 50 2,000 1,549E-03 0,01619571 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,561E-03 0,01624728 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 1,561E-03 0,0161741 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,561E-03 0,01610157 ! regulation of cellular pH GO:0030641 20 13 1,000 1,561E-03 0,01602969 ! lymphocyte homeostasis GO:0002260 24 13 1,000 1,561E-03 0,01595844 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,641E-03 0,01669622 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 1,816E-03 0,01839945 ! regulation of S phase GO:0033261 18 14 1,000 1,816E-03 0,01831875 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,816E-03 0,01823876 ! heterophilic cell adhesion GO:0007157 29 14 1,000 1,816E-03 0,01815946 ! startle response GO:0001964 21 14 1,000 1,816E-03 0,01808085 ! epidermis morphogenesis GO:0048730 29 14 1,000 1,816E-03 0,01800291 ! cellular response to starvation GO:0009267 21 14 1,000 1,816E-03 0,01792564 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,816E-03 0,01784904 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,816E-03 0,01777309 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 1,816E-03 0,01769778 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 1,816E-03 0,0176231 ! kidney development GO:0001822 90 53 2,000 1,833E-03 0,01771795 ! positive regulation of cell size GO:0045793 20 15 1,000 2,089E-03 0,02010444 ! lipid phosphorylation GO:0046834 23 15 1,000 2,089E-03 0,02002067 ! regulation of neurotransmitter secretion GO:0046928 26 15 1,000 2,089E-03 0,0199376 ! myoblast differentiation GO:0045445 27 15 1,000 2,089E-03 0,01985521 ! regulation of survival gene product expression GO:0045884 20 15 1,000 2,089E-03 0,0197735 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 2,089E-03 0,01969246 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 2,089E-03 0,01961209 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 2,089E-03 0,01953236 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 2,089E-03 0,01945328 ! defense response to virus GO:0051607 27 15 1,000 2,089E-03 0,01937484 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 2,148E-03 0,01984331 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 2,148E-03 0,01976394 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 2,26E-03 0,02071082 ! negative regulation of kinase activity GO:0033673 100 58 2,000 2,376E-03 0,02168266 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,38E-03 0,02164079 ! bone remodeling GO:0046849 24 16 1,000 2,38E-03 0,02155559 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,38E-03 0,02147105 ! patterning of blood vessels GO:0001569 24 16 1,000 2,38E-03 0,02138718 ! cellular response to unfolded protein GO:0034620 19 16 1,000 2,38E-03 0,02130396 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 2,38E-03 0,02122139 ! G1 phase GO:0051318 27 16 1,000 2,38E-03 0,02113946 ! neutrophil chemotaxis GO:0030593 21 16 1,000 2,38E-03 0,02105815 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,38E-03 0,02097747 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 1,000 2,38E-03 0,0208974 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 2,38E-03 0,02081794 ! regulation of homeostatic process GO:0032844 105 60 2,000 2,617E-03 0,02280363 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 2,617E-03 0,02271758 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of cell killing GO:0031343 24 17 1,000 2,69E-03 0,0232585 ! cell-substrate junction assembly GO:0007044 39 17 1,000 2,69E-03 0,02317139 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 2,69E-03 0,02308493 ! actin filament bundle formation GO:0051017 26 17 1,000 2,69E-03 0,02299911 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 2,69E-03 0,02291393 GO:0002712|regulation of B cell mediated immunity, ! synaptogenesis GO:0007416 24 17 1,000 2,69E-03 0,02282938 ! peptidyl-serine modification GO:0018209 27 17 1,000 2,69E-03 0,02274545 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 2,69E-03 0,02266213 ! proximal/distal pattern formation GO:0009954 25 17 1,000 2,69E-03 0,02257942 ! urogenital system development GO:0001655 101 61 2,000 2,744E-03 0,02294852 ! negative regulation of transferase activity GO:0051348 105 61 2,000 2,744E-03 0,02286537 ! positive regulation of DNA replication GO:0045740 29 18 1,000 3,017E-03 0,02505236 ! pigmentation during development GO:0048066 31 18 1,000 3,017E-03 0,02496225 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 3,017E-03 0,02487278 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 3,017E-03 0,02478395 ! somitogenesis GO:0001756 24 18 1,000 3,017E-03 0,02469575 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 3,017E-03 0,02460817 ! cellular response to nutrient levels GO:0031669 27 18 1,000 3,017E-03 0,02452122 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 3,017E-03 0,02443488 ! cell cycle checkpoint GO:0000075 108 64 2,000 3,145E-03 0,02538376 ! appendage morphogenesis GO:0035107 93 64 2,000 3,145E-03 0,02529501 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 94 65 2,000 3,287E-03 0,02634022 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 3,287E-03 0,02624876 ! positive regulation of T cell activation GO:0050870 94 65 2,000 3,287E-03 0,02615793 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 3,362E-03 0,0266654 ! apoptotic nuclear changes GO:0030262 24 19 1,000 3,362E-03 0,02657377 ! response to starvation GO:0042594 30 19 1,000 3,362E-03 0,02648276 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 3,362E-03 0,02639238 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 3,362E-03 0,02630261 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 3,362E-03 0,02621345 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 32 19 1,000 3,362E-03 0,02612489 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 3,362E-03 0,02603693 ! sex determination GO:0007530 29 19 1,000 3,362E-03 0,02594955 ! regulation of neurotransmitter transport GO:0051588 35 20 1,000 3,725E-03 0,0286514 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 3,725E-03 0,0285559 ! DNA modification GO:0006304 28 20 1,000 3,725E-03 0,02846103 ! collagen fibril organization GO:0030199 45 20 1,000 3,725E-03 0,02836679 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 3,725E-03 0,02827317 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 3,725E-03 0,02818016 ! activation of protein kinase activity GO:0032147 102 69 2,000 3,891E-03 0,02934389 ! response to drug GO:0042493 108 69 2,000 3,891E-03 0,029248 ! regulation of cell killing GO:0031341 34 21 1,000 4,105E-03 0,03075093 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 4,105E-03 0,03065109 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 4,105E-03 0,0305519 ! protein amino acid acylation GO:0043543 37 21 1,000 4,105E-03 0,03045334 ! regulation of DNA recombination GO:0000018 40 21 1,000 4,105E-03 0,03035542 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 4,105E-03 0,03025813 ! cell aging GO:0007569 32 21 1,000 4,105E-03 0,03016146 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 4,105E-03 0,0300654 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 4,105E-03 0,02996996 ! immunoglobulin production GO:0002377 33 21 1,000 4,105E-03 0,02987512 GO:0002440|production of molecular mediator of immune response, ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 4,105E-03 0,02978087 ! lymphocyte differentiation GO:0030098 113 71 2,000 4,217E-03 0,03050166 ! leukocyte adhesion GO:0007159 38 22 1,000 4,502E-03 0,03245734 ! molting cycle process GO:0022404 40 22 1,000 4,502E-03 0,03235592 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 4,502E-03 0,03225512 ! vasculogenesis GO:0001570 33 22 1,000 4,502E-03 0,03215495 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 4,502E-03 0,0320554 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 4,502E-03 0,03195646 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! leukocyte homeostasis GO:0001776 33 22 1,000 4,502E-03 0,03185813 ! mitochondrion organization GO:0007005 104 73 2,000 4,559E-03 0,03216641 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 4,916E-03 0,03457636 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 4,916E-03 0,03447094 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 4,916E-03 0,03436616 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 4,916E-03 0,03426202 ! negative regulation of DNA replication GO:0008156 35 23 1,000 4,916E-03 0,03415851 ! interaction with host GO:0051701 37 23 1,000 4,916E-03 0,03405563 ! lymphocyte proliferation GO:0046651 36 23 1,000 4,916E-03 0,03395336 ! cellular response to oxidative stress GO:0034599 33 23 1,000 4,916E-03 0,0338517 ! regulation of protein transport GO:0051223 114 76 2,000 5,103E-03 0,03503584 GO:0070201|regulation of establishment of protein localization, ! positive regulation of cell projection organization GO:0031346 39 24 1,000 5,347E-03 0,03660087 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 5,347E-03 0,03649226 ! fat cell differentiation GO:0045444 37 24 1,000 5,347E-03 0,0363843 ! mitochondrial membrane organization GO:0007006 39 24 1,000 5,347E-03 0,03627697 ! negative regulation of cell development GO:0010721 56 24 1,000 5,347E-03 0,03617027 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 5,347E-03 0,0360642 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 5,347E-03 0,03595875 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 5,347E-03 0,03585392 ! T cell activation GO:0042110 134 79 2,000 5,684E-03 0,03800593 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 5,795E-03 0,03863131 ! iron ion homeostasis GO:0055072 39 25 1,000 5,795E-03 0,03851966 ! regulation of chromosome organization GO:0033044 35 25 1,000 5,795E-03 0,03840865 ! leukocyte proliferation GO:0070661 39 25 1,000 5,795E-03 0,03829828 GO:0032943|mononuclear cell proliferation, ! regulation of neurological system process GO:0031644 122 81 2,000 6,093E-03 0,04015502 ! regulation of pH GO:0006885 36 26 1,000 6,259E-03 0,04113094 ! negative regulation of protein modification process GO:0031400 50 26 1,000 6,259E-03 0,04101376 ! biogenic amine metabolic process GO:0006576 121 83 2,000 6,519E-03 0,04259557 ! response to ionizing radiation GO:0010212 47 27 1,000 6,74E-03 0,04391392 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 6,74E-03 0,04378987 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 6,962E-03 0,04510723 ! regulation of protein localization GO:0032880 132 85 2,000 6,962E-03 0,04498052 ! cell junction assembly GO:0034329 56 28 1,000 7,237E-03 0,04662408 ! immune response-activating signal transduction GO:0002757 38 28 1,000 7,237E-03 0,04649385 GO:0002764|immune response-regulating signal transduction, ! BMP signaling pathway GO:0030509 40 28 1,000 7,237E-03 0,04636434 ! myeloid leukocyte activation GO:0002274 39 28 1,000 7,237E-03 0,04623555 ! neural tube formation GO:0001841 41 28 1,000 7,237E-03 0,04610747 ! positive regulation of catabolic process GO:0009896 40 28 1,000 7,237E-03 0,04598011 ! skeletal muscle tissue development GO:0007519 123 87 2,000 7,423E-03 0,04703242 GO:0060538|skeletal muscle organ development, ! protein processing GO:0016485 114 88 2,000 7,66E-03 0,04840066 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 7,75E-03 0,04883568 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 7,75E-03 0,04870225 ! regulation of neurogenesis GO:0050767 153 89 2,000 7,901E-03 0,04951804 ! regulation of T cell activation GO:0050863 128 89 2,000 7,901E-03 0,04938348 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 8,279E-03 0,05160417 ! adult locomotory behavior GO:0008344 47 30 1,000 8,279E-03 0,0514647 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 8,279E-03 0,05132598 ! positive regulation of immune effector process GO:0002699 40 30 1,000 8,279E-03 0,05118801 ! cell fate commitment GO:0045165 141 92 2,000 8,652E-03 0,05335288 ! positive regulation of immune response GO:0050778 121 92 2,000 8,652E-03 0,05321023 ! odontogenesis GO:0042476 50 31 1,000 8,824E-03 0,0541205 ! segmentation GO:0035282 41 31 1,000 8,824E-03 0,05397657 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 8,824E-03 0,05383339 ! response to mechanical stimulus GO:0009612 43 31 1,000 8,824E-03 0,05369098 ! leukocyte chemotaxis GO:0030595 43 31 1,000 8,824E-03 0,05354931 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 8,824E-03 0,05340839 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 9,385E-03 0,05665204 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 9,385E-03 0,05650373 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 9,385E-03 0,0563562 ! angiogenesis GO:0001525 149 95 2,000 9,444E-03 0,05656635 ! protein maturation GO:0051604 129 96 2,000 9,717E-03 0,05805026 ! ear morphogenesis GO:0042471 42 33 1,000 9,961E-03 0,05935053 ! cell junction organization GO:0034330 63 33 1,000 9,961E-03 0,05919717 ! carbohydrate homeostasis GO:0033500 39 33 1,000 9,961E-03 0,0590446 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 9,961E-03 0,05889281 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 9,961E-03 0,0587418 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,01055195 0,06207027 ! embryonic organ development GO:0048568 45 34 1,000 0,01055195 0,06191193 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,01055195 0,06175439 ! calcium ion transport GO:0006816 167 99 2,000 0,01056357 0,06166551 ! extracellular structure organization GO:0043062 156 99 2,000 0,01056357 0,06150939 ! divalent metal ion transport GO:0070838 171 100 2,000 0,01085494 0,06304635 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01115852 0,06464635 ! protein homooligomerization GO:0051260 52 35 1,000 0,01115852 0,06448392 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01178015 0,0679056 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01178015 0,06773584 ! tissue remodeling GO:0048771 62 36 1,000 0,01178015 0,06756692 ! neural tube development GO:0021915 50 36 1,000 0,01178015 0,06739884 ! glucan metabolic process GO:0044042 49 36 1,000 0,01178015 0,0672316 GO:0006073|cellular glucan metabolic process, ! amino acid activation GO:0043038 52 37 1,000 0,01241667 0,07068898 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,01306796 0,07421308 ! gliogenesis GO:0042063 71 38 1,000 0,01306796 0,07403029 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,01306796 0,0738484 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,01373385 0,07742121 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,01373385 0,07723192 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,01373385 0,07704355 ! synapse organization GO:0050808 55 39 1,000 0,01373385 0,07685609 ! response to calcium ion GO:0051592 58 40 1,000 0,01441421 0,08046768 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,01441421 0,08027285 ! double-strand break repair GO:0006302 67 40 1,000 0,01441421 0,08007895 ! B cell differentiation GO:0030183 62 40 1,000 0,01441421 0,07988599 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,0151089 0,08353477 ! glucose transport GO:0015758 52 41 1,000 0,0151089 0,08333445 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,0151089 0,08313508 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,0151089 0,08293667 ! biopolymer methylation GO:0043414 62 41 1,000 0,0151089 0,0827392 ! mitochondrial transport GO:0006839 60 42 1,000 0,01581777 0,08641535 ! cellular component disassembly GO:0022411 64 42 1,000 0,01581777 0,08621058 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,01581777 0,08600677 ! hexose transport GO:0008645 54 42 1,000 0,01581777 0,08580392 GO:0015749|monosaccharide transport, ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01581777 0,08560203 ! positive regulation of binding GO:0051099 59 43 1,000 0,01654068 0,08930413 ! leukocyte migration GO:0050900 60 43 1,000 0,01654068 0,08909498 ! neuromuscular process GO:0050905 79 43 1,000 0,01654068 0,08888682 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,01654068 0,08867962 ! methylation GO:0032259 64 43 1,000 0,01654068 0,08847339 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,01727749 0,09220006 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,01727749 0,09198664 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,01802807 0,09576109 ! histone modification GO:0016570 68 46 1,000 0,01879227 0,09959035 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,01879227 0,0993614 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01956995 0,10323599 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01956995 0,10299975 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,02036099 0,10691845 ! cartilage development GO:0051216 70 49 1,000 0,02116525 0,11088854 ! ear development GO:0043583 72 50 1,000 0,02198258 0,11490897 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,02198258 0,1146484 ! lipid modification GO:0030258 73 50 1,000 0,02198258 0,11438902 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,02198258 0,1141308 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,02198258 0,11387375 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02267479 0,11719556 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02267479 0,11693279 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02267479 0,1166712 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02267479 0,11641077 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02267479 0,1161515 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02267479 0,11589339 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02267479 0,11563642 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02267479 0,11538059 ! sleep GO:0030431 11 5 0,000 0,02267479 0,11512588 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02267479 0,1148723 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02267479 0,11461984 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02267479 0,11436848 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02267479 0,11411822 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02267479 0,11386905 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02267479 0,11362097 ! tongue development GO:0043586 6 5 0,000 0,02267479 0,11337397 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02267479 0,11312804 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02267479 0,11288317 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02267479 0,11263936 ! cobalt ion transport GO:0006824 9 5 0,000 0,02267479 0,11239661 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02267479 0,11215489 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02267479 0,11191422 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02267479 0,11167457 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02267479 0,11143595 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02267479 0,11119835 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02267479 0,11096176 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02267479 0,11072617 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02267479 0,11049158 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02267479 0,11025798 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02267479 0,11002537 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02267479 0,10979374 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02267479 0,10956308 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02267479 0,10933339 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02267479 0,10910466 ! malate metabolic process GO:0006108 7 5 0,000 0,02267479 0,10887688 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02267479 0,10865005 ! behavioral response to pain GO:0048266 7 5 0,000 0,02267479 0,10842417 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02267479 0,10819922 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02267479 0,10797521 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02267479 0,10775212 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02267479 0,10752995 ! mating behavior GO:0007617 6 5 0,000 0,02267479 0,10730869 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02267479 0,10708835 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02267479 0,1068689 ! rhythmic behavior GO:0007622 12 5 0,000 0,02267479 0,10665036 ! copulation GO:0007620 7 5 0,000 0,02267479 0,10643271 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02267479 0,10621594 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02267479 0,10600005 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02267479 0,10578504 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02267479 0,1055709 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02267479 0,10535763 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02267479 0,10514521 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02267479 0,10493365 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02267479 0,10472294 ! response to protozoan GO:0001562 9 5 0,000 0,02267479 0,10451308 ! lymph vessel development GO:0001945 7 5 0,000 0,02267479 0,10430405 ! endochondral ossification GO:0001958 12 5 0,000 0,02267479 0,10409586 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02267479 0,1038885 ! parathyroid gland development GO:0060017 8 5 0,000 0,02267479 0,10368196 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02267479 0,10347624 ! anagen GO:0042640 6 5 0,000 0,02267479 0,10327134 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02267479 0,10306724 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02267479 0,10286396 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02267479 0,10266147 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02267479 0,10245978 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02267479 0,10225887 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02267479 0,10205876 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02267479 0,10185942 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02267479 0,10166087 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02267479 0,10146308 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02267479 0,10126607 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02267479 0,10106982 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02267479 0,10087432 ! ovulation GO:0030728 6 5 0,000 0,02267479 0,10067959 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02267479 0,1004856 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02267479 0,10029236 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02267479 0,10009986 ! response to pH GO:0009268 9 5 0,000 0,02267479 0,09990809 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02267479 0,09971707 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02267479 0,09952677 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02267479 0,09933719 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02267479 0,09914834 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02267479 0,0989602 ! polyol catabolic process GO:0046174 7 5 0,000 0,02267479 0,09877278 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02267479 0,09858606 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02267479 0,09840005 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02267479 0,09821474 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02267479 0,09803012 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02267479 0,0978462 ! urea metabolic process GO:0019627 6 5 0,000 0,02267479 0,09766297 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02267479 0,09748042 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02267479 0,09729856 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02267479 0,09711737 ! neutrophil activation GO:0042119 5 5 0,000 0,02267479 0,09693685 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02267479 0,096757 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02267479 0,09657782 ! response to food GO:0032094 5 5 0,000 0,02267479 0,09639931 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02267479 0,09622145 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02267479 0,09604425 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02267479 0,09586769 ! forebrain neuron development GO:0021884 7 5 0,000 0,02267479 0,09569179 ! melanosome organization GO:0032438 7 5 0,000 0,02267479 0,09551653 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02267479 0,09534191 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02267479 0,09516793 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02267479 0,09499458 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02267479 0,09482186 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02267479 0,09464977 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02267479 0,09447831 ! nucleoside transport GO:0015858 6 5 0,000 0,02267479 0,09430746 ! nucleoside salvage GO:0043174 7 5 0,000 0,02267479 0,09413723 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02267479 0,09396761 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02267479 0,09379861 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02267479 0,09363021 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02267479 0,09346241 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02267479 0,09329522 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02267479 0,09312862 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02267479 0,09296261 ! depyrimidination GO:0045008 8 5 0,000 0,02267479 0,0927972 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02267479 0,09263237 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02267479 0,09246813 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02267479 0,09230447 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02267479 0,09214139 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02267479 0,09197888 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02267479 0,09181695 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02267479 0,09165558 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02267479 0,09149478 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02267479 0,09133455 ! monocyte differentiation GO:0030224 8 5 0,000 0,02267479 0,09117487 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02267479 0,09101575 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02267479 0,09085719 ! centrosome duplication GO:0051298 5 5 0,000 0,02267479 0,09069917 ! response to UV-C GO:0010225 6 5 0,000 0,02267479 0,09054171 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02267479 0,09038479 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02267479 0,09022842 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02267479 0,09007258 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02267479 0,08991729 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02267479 0,08976252 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02267479 0,08960829 ! melanosome transport GO:0032402 8 5 0,000 0,02267479 0,08945459 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02267479 0,08930141 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02267479 0,08914876 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02267479 0,08899663 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02267479 0,08884502 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02267479 0,08869392 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02267479 0,08854334 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02267479 0,08839326 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02267479 0,0882437 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02267479 0,08809464 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02267479 0,08794608 ! neural tube patterning GO:0021532 6 5 0,000 0,02267479 0,08779802 ! histone demethylation GO:0016577 9 5 0,000 0,02267479 0,08765046 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02267479 0,0875034 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02267479 0,08735683 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02267479 0,08721074 ! enteric nervous system development GO:0048484 8 5 0,000 0,02267479 0,08706515 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02267479 0,08692004 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02267479 0,08677542 ! transcription termination GO:0006353 8 5 0,000 0,02267479 0,08663127 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02267479 0,0864876 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02267479 0,08634441 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02267479 0,0862017 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02267479 0,08605945 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02267479 0,08591767 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,02267479 0,08577636 ! apical protein localization GO:0045176 6 5 0,000 0,02267479 0,08563551 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02267479 0,08549512 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02267479 0,0853552 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02267479 0,08521573 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02267479 0,08507671 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02267479 0,08493815 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02267479 0,08480004 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02267479 0,08466238 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02267479 0,08452516 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02267479 0,08438839 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02267479 0,08425206 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02267479 0,08411617 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02267479 0,08398072 ! neural plate development GO:0001840 6 5 0,000 0,02267479 0,0838457 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02267479 0,08371112 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02267479 0,08357696 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02267479 0,08344324 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02267479 0,08330994 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02267479 0,08317707 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02267479 0,08304463 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02267479 0,0829126 ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02267479 0,08278099 ! spindle assembly GO:0051225 5 5 0,000 0,02267479 0,0826498 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02267479 0,08251903 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02267479 0,08238867 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02267479 0,08225872 ! organ regeneration GO:0031100 7 5 0,000 0,02267479 0,08212917 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02267479 0,08200004 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02267479 0,08187131 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02267479 0,08174299 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02267479 0,08161506 GO:0055081|anion homeostasis, ! muscle fiber development GO:0048747 74 51 1,000 0,02281287 0,08198375 ! adult behavior GO:0030534 80 51 1,000 0,02281287 0,08185585 ! aging GO:0007568 79 52 1,000 0,02365597 0,08474881 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,02365597 0,08461701 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,0253801 0,09064321 ! DNA catabolic process GO:0006308 67 54 1,000 0,0253801 0,09050268 ! detection of external stimulus GO:0009581 66 54 1,000 0,0253801 0,09036258 ! tRNA transcription GO:0009304 11 6 0,000 0,02714845 0,09650916 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02714845 0,09636022 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02714845 0,09621175 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02714845 0,09606373 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02714845 0,09591617 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02714845 0,09576906 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02714845 0,0956224 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02714845 0,09547619 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02714845 0,09533042 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02714845 0,0951851 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02714845 0,09504022 ! prostate gland development GO:0030850 9 6 0,000 0,02714845 0,09489578 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02714845 0,09475178 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02714845 0,09460822 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02714845 0,09446509 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02714845 0,09432239 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02714845 0,09418013 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02714845 0,09403829 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02714845 0,09389688 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02714845 0,09375589 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02714845 0,09361533 ! neuron adhesion GO:0007158 9 6 0,000 0,02714845 0,09347519 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02714845 0,09333546 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02714845 0,09319616 ! signal peptide processing GO:0006465 8 6 0,000 0,02714845 0,09305727 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02714845 0,09291879 ! mRNA stabilization GO:0048255 15 6 0,000 0,02714845 0,09278072 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02714845 0,09264306 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02714845 0,09250582 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02714845 0,09236897 ! opsonization GO:0008228 8 6 0,000 0,02714845 0,09223253 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02714845 0,0920965 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02714845 0,09196086 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02714845 0,09182563 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02714845 0,09169079 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02714845 0,09155634 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02714845 0,09142229 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02714845 0,09128863 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02714845 0,09115537 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02714845 0,09102249 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02714845 0,09088999 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02714845 0,09075789 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02714845 0,09062616 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02714845 0,09049482 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02714845 0,09036386 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02714845 0,09023327 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02714845 0,09010307 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02714845 0,08997324 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02714845 0,08984378 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02714845 0,08971469 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02714845 0,08958598 ! protein lipoylation GO:0009249 10 6 0,000 0,02714845 0,08945763 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02714845 0,08932965 ! pigment granule organization GO:0048753 11 6 0,000 0,02714845 0,08920204 ! drug transport GO:0015893 6 6 0,000 0,02714845 0,08907479 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02714845 0,0889479 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02714845 0,08882137 ! histidine metabolic process GO:0006547 6 6 0,000 0,02714845 0,08869521 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02714845 0,0885694 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02714845 0,08844394 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02714845 0,08831885 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02714845 0,0881941 ! adenohypophysis development GO:0021984 10 6 0,000 0,02714845 0,08806971 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02714845 0,08794567 ! hyperosmotic response GO:0006972 8 6 0,000 0,02714845 0,08782198 ! microtubule nucleation GO:0007020 10 6 0,000 0,02714845 0,08769863 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02714845 0,08757563 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02714845 0,08745298 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02714845 0,08733066 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02714845 0,08720869 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02714845 0,08708706 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02714845 0,08696577 ! response to dietary excess GO:0002021 7 6 0,000 0,02714845 0,08684482 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02714845 0,0867242 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02714845 0,08660392 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02714845 0,08648397 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02714845 0,08636435 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02714845 0,08624506 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02714845 0,0861261 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02714845 0,08600747 ! neuron apoptosis GO:0051402 8 6 0,000 0,02714845 0,08588917 ! organic alcohol transport GO:0015850 9 6 0,000 0,02714845 0,08577119 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02714845 0,08565353 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02714845 0,0855362 ! carnitine transport GO:0015879 8 6 0,000 0,02714845 0,08541919 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02714845 0,08530249 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02714845 0,08518612 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02714845 0,08507006 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02714845 0,08495432 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02714845 0,08483889 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02714845 0,08472378 ! parturition GO:0007567 12 6 0,000 0,02714845 0,08460898 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02714845 0,08449449 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02714845 0,0843803 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02714845 0,08426643 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02714845 0,08415286 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02714845 0,0840396 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02714845 0,08392665 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02714845 0,08381399 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02714845 0,08370164 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02714845 0,08358959 ! macrophage differentiation GO:0030225 10 6 0,000 0,02714845 0,08347784 ! astrocyte development GO:0014002 14 6 0,000 0,02714845 0,08336639 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02714845 0,08325523 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02714845 0,08314437 ! interaction with symbiont GO:0051702 8 6 0,000 0,02714845 0,08303381 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02714845 0,08292354 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02714845 0,08281356 ! eating behavior GO:0042755 6 6 0,000 0,02714845 0,08270387 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02714845 0,08259448 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02714845 0,08248537 ! response to copper ion GO:0046688 9 6 0,000 0,02714845 0,08237655 ! DNA topological change GO:0006265 8 6 0,000 0,02714845 0,08226802 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02714845 0,08215977 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02714845 0,08205181 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02714845 0,08194413 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02714845 0,08183673 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02714845 0,08172961 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02714845 0,08162278 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02714845 0,08151622 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02714845 0,08140994 ! gas homeostasis GO:0033483 11 6 0,000 0,02714845 0,08130394 ! hair follicle maturation GO:0048820 7 6 0,000 0,02714845 0,08119821 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02714845 0,08109276 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02714845 0,08098758 ! Schwann cell development GO:0014044 14 6 0,000 0,02714845 0,08088268 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02714845 0,08077804 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02714845 0,08067368 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02714845 0,08056958 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02714845 0,08046575 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02714845 0,08036219 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02714845 0,0802589 ! histone ubiquitination GO:0016574 7 6 0,000 0,02714845 0,08015587 ! regulation of meiosis GO:0040020 10 6 0,000 0,02714845 0,08005311 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02714845 0,07995061 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02714845 0,07984837 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02714845 0,07974639 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02714845 0,07964467 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02714845 0,07954322 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02714845 0,07944202 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02714845 0,07934107 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02714845 0,07924039 ! receptor internalization GO:0031623 9 6 0,000 0,02714845 0,07913996 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02714845 0,07903978 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02714845 0,07893985 ! protein deubiquitination GO:0016579 8 6 0,000 0,02714845 0,07884018 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02714845 0,07874076 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02714845 0,07864159 ! axonal fasciculation GO:0007413 9 6 0,000 0,02714845 0,07854267 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02714845 0,078444 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02714845 0,07834558 ! midbrain development GO:0030901 6 6 0,000 0,02714845 0,0782474 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02714845 0,07814947 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02714845 0,07805178 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02714845 0,07795434 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02714845 0,07785714 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02714845 0,07776018 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02714845 0,07766346 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02714845 0,07756699 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02714845 0,07747075 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02714845 0,07737475 ! adult feeding behavior GO:0008343 6 6 0,000 0,02714845 0,07727899 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02714845 0,07718347 ! blastocyst growth GO:0001832 15 6 0,000 0,02714845 0,07708818 ! pigment granule transport GO:0051904 12 6 0,000 0,02714845 0,07699313 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02714845 0,07689831 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02714845 0,07680372 ! catecholamine transport GO:0051937 7 6 0,000 0,02714845 0,07670937 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02714845 0,07661525 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02714845 0,07652135 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02714845 0,07642769 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02714845 0,07633426 ! protein prenylation GO:0018342 10 6 0,000 0,02714845 0,07624106 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02714845 0,07614808 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02714845 0,07605533 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02714845 0,0759628 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02714845 0,0758705 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02714845 0,07577843 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,02715392 0,07570184 ! carbohydrate transport GO:0008643 74 57 1,000 0,02805915 0,0781308 ! viral reproductive process GO:0022415 87 58 1,000 0,02897642 0,08058737 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,02897642 0,08049005 ! lung development GO:0030324 94 59 1,000 0,0299056 0,0829709 ! actin filament organization GO:0007015 95 59 1,000 0,0299056 0,08287093 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,0299056 0,08277121 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03084657 0,08527297 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,03084657 0,0851706 ! regulation of heart contraction GO:0008016 91 60 1,000 0,03084657 0,08506847 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03160187 0,08704708 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03160187 0,08694296 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03160187 0,08683908 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03160187 0,08673546 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03160187 0,08663208 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03160187 0,08652894 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03160187 0,08642605 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03160187 0,08632341 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03160187 0,08622101 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03160187 0,08611885 ! reproductive behavior GO:0019098 12 7 0,000 0,03160187 0,08601694 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03160187 0,08591526 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03160187 0,08581383 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03160187 0,08571263 ! oligopeptide transport GO:0006857 11 7 0,000 0,03160187 0,08561167 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03160187 0,08551095 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03160187 0,08541047 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03160187 0,08531023 ! RNA methylation GO:0001510 11 7 0,000 0,03160187 0,08521021 ! pericardium development GO:0060039 8 7 0,000 0,03160187 0,08511044 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03160187 0,08501089 ! fibril organization GO:0043206 13 7 0,000 0,03160187 0,08491158 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03160187 0,0848125 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03160187 0,08471365 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03160187 0,08461503 ! lipoprotein transport GO:0042953 9 7 0,000 0,03160187 0,08451664 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03160187 0,08441848 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03160187 0,08432055 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03160187 0,08422284 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03160187 0,08412536 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03160187 0,08402811 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03160187 0,08393108 ! chemosensory behavior GO:0007635 9 7 0,000 0,03160187 0,08383427 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03160187 0,08373769 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,03160187 0,08364133 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03160187 0,08354519 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03160187 0,08344927 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03160187 0,08335357 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03160187 0,08325809 ! reflex GO:0060004 12 7 0,000 0,03160187 0,08316283 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03160187 0,08306778 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03160187 0,08297296 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03160187 0,08287835 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03160187 0,08278395 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03160187 0,08268977 ! spinal cord patterning GO:0021511 7 7 0,000 0,03160187 0,08259581 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03160187 0,08250206 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03160187 0,08240852 ! adrenal gland development GO:0030325 17 7 0,000 0,03160187 0,08231519 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03160187 0,08222207 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03160187 0,08212917 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03160187 0,08203647 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03160187 0,08194398 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03160187 0,0818517 ! endosome organization GO:0007032 10 7 0,000 0,03160187 0,08175963 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03160187 0,08166777 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03160187 0,08157611 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03160187 0,08148465 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03160187 0,08139341 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03160187 0,08130236 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03160187 0,08121152 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03160187 0,08112088 ! galactose metabolic process GO:0006012 10 7 0,000 0,03160187 0,08103045 ! vesicle fusion GO:0006906 15 7 0,000 0,03160187 0,08094021 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03160187 0,08085018 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03160187 0,08076035 ! organ growth GO:0035265 11 7 0,000 0,03160187 0,08067071 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03160187 0,08058128 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03160187 0,08049204 ! retinol metabolic process GO:0042572 9 7 0,000 0,03160187 0,080403 ! behavioral fear response GO:0001662 13 7 0,000 0,03160187 0,08031416 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03160187 0,08022551 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03160187 0,08013706 ! rRNA modification GO:0000154 12 7 0,000 0,03160187 0,0800488 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03160187 0,07996074 ! response to UV-B GO:0010224 11 7 0,000 0,03160187 0,07987287 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03160187 0,07978519 ! intermediate filament organization GO:0045109 11 7 0,000 0,03160187 0,07969771 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03160187 0,07961042 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03160187 0,07952332 ! fibrinolysis GO:0042730 9 7 0,000 0,03160187 0,07943641 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03160187 0,07934969 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03160187 0,07926315 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03160187 0,07917681 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03160187 0,07909065 ! response to tropane GO:0014073 13 7 0,000 0,03160187 0,07900469 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03160187 0,07891891 ! melanosome localization GO:0032400 10 7 0,000 0,03160187 0,07883331 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03160187 0,0787479 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03160187 0,07866268 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03160187 0,07857763 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03160187 0,07849278 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03160187 0,0784081 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03160187 0,07832361 ! mast cell activation GO:0045576 9 7 0,000 0,03160187 0,0782393 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03160187 0,07815517 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03160187 0,07807123 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03160187 0,07798746 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03160187 0,07790387 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,03160187 0,07782046 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03160187 0,07773723 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03160187 0,07765418 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03160187 0,0775713 ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03160187 0,07748861 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03160187 0,07740608 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03160187 0,07732374 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03160187 0,07724156 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03160187 0,07715957 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03160187 0,07707774 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03160187 0,07699609 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03160187 0,07691462 ! diuresis GO:0030146 12 7 0,000 0,03160187 0,07683331 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03160187 0,07675218 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03160187 0,07667121 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03160187 0,07659042 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03160187 0,0765098 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03160187 0,07642935 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03160187 0,07634907 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03160187 0,07626895 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03160187 0,07618901 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03160187 0,07610923 ! lymph node development GO:0048535 9 7 0,000 0,03160187 0,07602961 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03160187 0,07595017 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03160187 0,07587089 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03160187 0,07579177 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03160187 0,07571282 ! ATP catabolic process GO:0006200 10 7 0,000 0,03160187 0,07563404 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03160187 0,07555542 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03160187 0,07547696 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03160187 0,07539866 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03160187 0,07532053 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03160187 0,07524256 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03160187 0,07516475 ! muscle adaptation GO:0043500 12 7 0,000 0,03160187 0,0750871 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03160187 0,07500961 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03160187 0,07493228 ! retina homeostasis GO:0001895 9 7 0,000 0,03160187 0,07485511 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03160187 0,0747781 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03160187 0,07470125 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03160187 0,07462455 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03160187 0,07454801 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03160187 0,07447163 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,0317992 0,07485995 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,0317992 0,0747834 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,0317992 0,07470701 ! extracellular matrix organization GO:0030198 103 61 1,000 0,0317992 0,07463078 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,0317992 0,07455471 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,0317992 0,07447878 ! respiratory tube development GO:0030323 99 62 1,000 0,03276338 0,07665897 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,03276338 0,07658107 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,03373897 0,07878136 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,03373897 0,07870146 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,03373897 0,07862172 ! viral reproduction GO:0016032 92 63 1,000 0,03373897 0,07854214 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,03472586 0,08075782 ! respiratory system development GO:0060541 100 64 1,000 0,03472586 0,08067625 ! B cell activation GO:0042113 104 65 1,000 0,03572393 0,08291124 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,03572393 0,08282766 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,03572393 0,08274424 ! activation of immune response GO:0002253 83 65 1,000 0,03572393 0,082661 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03603517 0,08329738 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03603517 0,08321375 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03603517 0,08313028 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03603517 0,08304699 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03603517 0,08296386 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03603517 0,08288089 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03603517 0,08279809 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03603517 0,08271546 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03603517 0,08263299 ! phosphate transport GO:0006817 10 8 0,000 0,03603517 0,08255069 ! N-glycan processing GO:0006491 12 8 0,000 0,03603517 0,08246855 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03603517 0,08238657 ! UTP metabolic process GO:0046051 8 8 0,000 0,03603517 0,08230476 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03603517 0,08222311 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03603517 0,08214162 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03603517 0,08206029 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03603517 0,08197912 ! succinate metabolic process GO:0006105 14 8 0,000 0,03603517 0,08189812 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03603517 0,08181727 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03603517 0,08173658 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03603517 0,08165605 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03603517 0,08157568 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03603517 0,08149547 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03603517 0,08141542 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03603517 0,08133552 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03603517 0,08125578 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03603517 0,08117619 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03603517 0,08109676 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03603517 0,08101749 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03603517 0,08093837 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03603517 0,08085941 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03603517 0,0807806 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03603517 0,08070194 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03603517 0,08062344 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03603517 0,08054509 ! melanin metabolic process GO:0006582 12 8 0,000 0,03603517 0,08046689 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03603517 0,08038884 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03603517 0,08031094 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03603517 0,0802332 ! macrophage activation GO:0042116 12 8 0,000 0,03603517 0,0801556 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03603517 0,08007816 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03603517 0,08000086 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03603517 0,07992372 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03603517 0,07984672 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03603517 0,07976987 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03603517 0,07969317 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03603517 0,07961661 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03603517 0,0795402 ! ruffle organization GO:0031529 11 8 0,000 0,03603517 0,07946394 ! osteoblast development GO:0002076 13 8 0,000 0,03603517 0,07938783 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03603517 0,07931186 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03603517 0,07923604 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03603517 0,07916036 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03603517 0,07908482 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03603517 0,07900943 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03603517 0,07893418 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03603517 0,07885908 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03603517 0,07878412 ! brain morphogenesis GO:0048854 20 8 0,000 0,03603517 0,0787093 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03603517 0,07863462 ! segment specification GO:0007379 10 8 0,000 0,03603517 0,07856009 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03603517 0,07848569 ! cellular extravasation GO:0045123 11 8 0,000 0,03603517 0,07841144 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03603517 0,07833733 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03603517 0,07826335 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03603517 0,07818952 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03603517 0,07811583 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03603517 0,07804227 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03603517 0,07796885 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03603517 0,07789558 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03603517 0,07782243 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03603517 0,07774943 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03603517 0,07767656 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03603517 0,07760383 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03603517 0,07753124 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03603517 0,07745878 ! icosanoid secretion GO:0032309 12 8 0,000 0,03603517 0,07738645 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03603517 0,07731427 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03603517 0,07724221 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03603517 0,07717029 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03603517 0,0770985 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03603517 0,07702685 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03603517 0,07695533 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03603517 0,07688395 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03603517 0,07681269 ! sterol catabolic process GO:0016127 9 8 0,000 0,03603517 0,07674157 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03603517 0,07667058 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03603517 0,07659972 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03603517 0,07652899 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03603517 0,07645839 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03603517 0,07638792 ! prophase GO:0051324 11 8 0,000 0,03603517 0,07631758 ! S phase GO:0051320 8 8 0,000 0,03603517 0,07624737 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03603517 0,07617729 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03603517 0,07610734 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03603517 0,07603752 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03603517 0,07596782 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03603517 0,07589825 ! hormone catabolic process GO:0042447 13 8 0,000 0,03603517 0,07582881 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03603517 0,0757595 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03603517 0,07569031 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03603517 0,07562125 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03603517 0,07555232 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03603517 0,07548351 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03603517 0,07541483 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03603517 0,07534627 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03603517 0,07527783 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03603517 0,07520952 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03603517 0,07514134 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03603517 0,07507327 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03603517 0,07500533 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03603517 0,07493752 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03603517 0,07486982 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,03673305 0,07625091 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,03673305 0,07618216 ! regulation of immune effector process GO:0002697 101 66 1,000 0,03673305 0,07611352 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,03775311 0,07815674 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,03878398 0,08021866 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,03878398 0,08014659 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,03982555 0,08222511 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04044842 0,08343621 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04044842 0,08336145 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04044842 0,08328682 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04044842 0,08321232 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04044842 0,08313796 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04044842 0,08306373 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04044842 0,08298963 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04044842 0,08291566 ! GTP metabolic process GO:0046039 9 9 0,000 0,04044842 0,08284183 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04044842 0,08276813 ! social behavior GO:0035176 14 9 0,000 0,04044842 0,08269456 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04044842 0,08262111 ! artery development GO:0060840 19 9 0,000 0,04044842 0,0825478 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04044842 0,08247462 ! response to pain GO:0048265 16 9 0,000 0,04044842 0,08240157 ! protein complex disassembly GO:0043241 17 9 0,000 0,04044842 0,08232865 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04044842 0,08225586 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04044842 0,08218319 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04044842 0,08211066 ! lung alveolus development GO:0048286 17 9 0,000 0,04044842 0,08203825 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04044842 0,08196597 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04044842 0,08189382 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04044842 0,08182179 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04044842 0,08174989 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04044842 0,08167812 ! protein targeting to ER GO:0045047 19 9 0,000 0,04044842 0,08160647 ! endoderm development GO:0007492 12 9 0,000 0,04044842 0,08153495 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04044842 0,08146355 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04044842 0,08139228 ! arginine catabolic process GO:0006527 10 9 0,000 0,04044842 0,08132113 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04044842 0,08125011 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04044842 0,08117921 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04044842 0,08110844 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04044842 0,08103778 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04044842 0,08096725 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04044842 0,08089685 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04044842 0,08082656 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04044842 0,0807564 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04044842 0,08068636 ! mannose metabolic process GO:0006013 9 9 0,000 0,04044842 0,08061644 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04044842 0,08054665 ! receptor clustering GO:0043113 15 9 0,000 0,04044842 0,08047697 ! epithelial cell development GO:0002064 10 9 0,000 0,04044842 0,08040741 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04044842 0,08033798 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04044842 0,08026866 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04044842 0,08019946 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04044842 0,08013038 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04044842 0,08006142 ! motor axon guidance GO:0008045 14 9 0,000 0,04044842 0,07999258 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04044842 0,07992386 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04044842 0,07985526 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04044842 0,07978677 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04044842 0,0797184 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04044842 0,07965015 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04044842 0,07958201 ! DNA ligation GO:0006266 14 9 0,000 0,04044842 0,079514 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04044842 0,07944609 ! response to amine stimulus GO:0014075 13 9 0,000 0,04044842 0,07937831 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04044842 0,07931064 ! erythrocyte development GO:0048821 11 9 0,000 0,04044842 0,07924308 ! renal water homeostasis GO:0003091 14 9 0,000 0,04044842 0,07917564 ! postreplication repair GO:0006301 11 9 0,000 0,04044842 0,07910831 ! mRNA cleavage GO:0006379 13 9 0,000 0,04044842 0,0790411 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04044842 0,078974 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04044842 0,07890702 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04044842 0,07884015 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04044842 0,07877339 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04044842 0,07870675 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04044842 0,07864022 ! acid secretion GO:0046717 14 9 0,000 0,04044842 0,0785738 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04044842 0,07850749 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04044842 0,07844129 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04044842 0,07837521 ! purine base metabolic process GO:0006144 18 9 0,000 0,04044842 0,07830924 ! oocyte differentiation GO:0009994 12 9 0,000 0,04044842 0,07824338 GO:0048599|oocyte development, ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04044842 0,07817763 ! spleen development GO:0048536 15 9 0,000 0,04044842 0,07811199 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04044842 0,07804646 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04044842 0,07798104 ! detection of calcium ion GO:0005513 13 9 0,000 0,04044842 0,07791572 ! blastocyst formation GO:0001825 12 9 0,000 0,04044842 0,07785052 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04044842 0,07778543 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04044842 0,07772045 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04044842 0,07765557 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04044842 0,07759081 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04044842 0,07752615 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04044842 0,07746159 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04044842 0,07739715 ! prepulse inhibition GO:0060134 14 9 0,000 0,04044842 0,07733281 ! embryonic placenta development GO:0001892 12 9 0,000 0,04044842 0,07726858 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04044842 0,07720446 ! insulin secretion GO:0030073 17 9 0,000 0,04044842 0,07714044 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04044842 0,07707653 ! response to nicotine GO:0035094 16 9 0,000 0,04044842 0,07701273 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04044842 0,07694903 ! nucleus localization GO:0051647 15 9 0,000 0,04044842 0,07688543 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04044842 0,07682194 ! localization within membrane GO:0051668 15 9 0,000 0,04044842 0,07675856 ! response to metal ion GO:0010038 103 70 1,000 0,04087771 0,07750926 ! eye development GO:0001654 111 70 1,000 0,04087771 0,07744541 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,04087771 0,07738167 ! regulation of catabolic process GO:0009894 106 70 1,000 0,04087771 0,07731804 ! muscle cell differentiation GO:0042692 104 71 1,000 0,04194033 0,07926275 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,04194033 0,07919767 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,04301331 0,08115719 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,04301331 0,08109067 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,04409652 0,0830647 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04484172 0,08439932 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04484172 0,08433031 ! neuron fate specification GO:0048665 11 10 0,000 0,04484172 0,08426141 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04484172 0,08419262 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04484172 0,08412395 ! thyroid gland development GO:0030878 19 10 0,000 0,04484172 0,08405539 ! synapsis GO:0007129 13 10 0,000 0,04484172 0,08398694 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04484172 0,0839186 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04484172 0,08385038 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04484172 0,08378226 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,04484172 0,08371426 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04484172 0,08364636 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,04484172 0,08357858 ! phospholipid efflux GO:0033700 16 10 0,000 0,04484172 0,0835109 ! hippocampus development GO:0021766 19 10 0,000 0,04484172 0,08344334 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04484172 0,08337588 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04484172 0,08330853 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04484172 0,0832413 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04484172 0,08317416 ! pathogenesis GO:0009405 13 10 0,000 0,04484172 0,08310714 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04484172 0,08304023 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04484172 0,08297342 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04484172 0,08290672 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04484172 0,08284013 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04484172 0,08277365 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04484172 0,08270727 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04484172 0,082641 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04484172 0,08257483 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04484172 0,08250877 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04484172 0,08244282 ! B cell proliferation GO:0042100 14 10 0,000 0,04484172 0,08237697 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04484172 0,08231122 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04484172 0,08224559 ! forebrain cell migration GO:0021885 17 10 0,000 0,04484172 0,08218005 ! lipid digestion GO:0044241 15 10 0,000 0,04484172 0,08211462 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04484172 0,0820493 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04484172 0,08198407 ! UV protection GO:0009650 14 10 0,000 0,04484172 0,08191896 ! entry into host cell GO:0030260 20 10 0,000 0,04484172 0,08185394 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04484172 0,08178903 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04484172 0,08172422 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04484172 0,08165951 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04484172 0,08159491 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04484172 0,08153041 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04484172 0,08146601 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04484172 0,08140171 ! regulation of organ growth GO:0046620 11 10 0,000 0,04484172 0,08133751 ! response to dsRNA GO:0043331 18 10 0,000 0,04484172 0,08127342 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04484172 0,08120942 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04484172 0,08114553 ! embryonic axis specification GO:0000578 12 10 0,000 0,04484172 0,08108173 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04484172 0,08101804 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04484172 0,08095445 ! cranial nerve development GO:0021545 12 10 0,000 0,04484172 0,08089095 ! fucose catabolic process GO:0019317 16 10 0,000 0,04484172 0,08082756 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04484172 0,08076426 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04484172 0,08070107 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04484172 0,08063797 ! zymogen activation GO:0031638 14 10 0,000 0,04484172 0,08057497 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04484172 0,08051207 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04484172 0,08044927 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04484172 0,08038657 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04484172 0,08032396 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04484172 0,08026145 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04484172 0,08019904 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04484172 0,08013672 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04484172 0,08007451 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04484172 0,08001239 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04484172 0,07995036 ! detection of bacterium GO:0016045 10 10 0,000 0,04484172 0,07988843 ! embryonic gut development GO:0048566 11 10 0,000 0,04484172 0,0798266 ! activation of innate immune response GO:0002218 10 10 0,000 0,04484172 0,07976486 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04484172 0,07970322 ! developmental induction GO:0031128 13 10 0,000 0,04484172 0,07964167 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04484172 0,07958022 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04484172 0,07951886 ! response to inorganic substance GO:0010035 115 75 1,000 0,04629321 0,08202957 ! regulation of ligase activity GO:0051340 114 75 1,000 0,04629321 0,08196642 ! amine biosynthetic process GO:0009309 97 76 1,000 0,04740646 0,08387296 ! tRNA metabolic process GO:0006399 95 76 1,000 0,04740646 0,08380849 ! response to unfolded protein GO:0006986 99 76 1,000 0,04740646 0,08374412 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,04740646 0,08367985 ! regulation of DNA binding GO:0051101 119 77 1,000 0,04852949 0,0855965 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,04852949 0,0855309 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,04852949 0,08546541 ! rRNA transcription GO:0009303 17 11 0,000 0,04921516 0,08660663 ! respiratory burst GO:0045730 14 11 0,000 0,04921516 0,08654042 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04921516 0,08647431 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04921516 0,08640829 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04921516 0,08634238 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,04921516 0,08627657 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,04921516 0,08621087 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,04921516 0,08614526 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04921516 0,08607975 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04921516 0,08601434 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,04921516 0,08594902 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,04921516 0,08588381 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,04921516 0,0858187 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04921516 0,08575369 ! bone resorption GO:0045453 16 11 0,000 0,04921516 0,08568877 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04921516 0,08562395 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04921516 0,08555923 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04921516 0,08549461 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04921516 0,08543009 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04921516 0,08536566 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04921516 0,08530133 ! syncytium formation GO:0006949 15 11 0,000 0,04921516 0,0852371 ! plasma membrane organization GO:0007009 18 11 0,000 0,04921516 0,08517296 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04921516 0,08510892 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04921516 0,08504498 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04921516 0,08498113 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04921516 0,08491738 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04921516 0,08485372 ! adult heart development GO:0007512 11 11 0,000 0,04921516 0,08479016 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04921516 0,0847267 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,04921516 0,08466333 ! temperature homeostasis GO:0001659 16 11 0,000 0,04921516 0,08460005 ! L-glutamate transport GO:0015813 16 11 0,000 0,04921516 0,08453687 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04921516 0,08447378 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04921516 0,08441079 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04921516 0,08434789 ! stem cell development GO:0048864 29 11 0,000 0,04921516 0,08428508 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04921516 0,08422237 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04921516 0,08415975 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04921516 0,08409723 ! vasoconstriction GO:0042310 15 11 0,000 0,04921516 0,08403479 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04921516 0,08397245 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04921516 0,0839102 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04921516 0,08384805 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04921516 0,08378599 ! ribosome assembly GO:0042255 13 11 0,000 0,04921516 0,08372401 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04921516 0,08366213 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04921516 0,08360034 ! chromatin silencing GO:0006342 19 11 0,000 0,04921516 0,08353865 ! nucleosome positioning GO:0016584 13 11 0,000 0,04921516 0,08347704 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04921516 0,08341552 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04921516 0,0833541 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04921516 0,08329276 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04921516 0,08323152 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04921516 0,08317036 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04921516 0,0831093 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04921516 0,08304832 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04921516 0,08298744 ! male genitalia development GO:0030539 13 11 0,000 0,04921516 0,08292664 ! cholesterol efflux GO:0033344 19 11 0,000 0,04921516 0,08286593 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04921516 0,08280532 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04921516 0,08274478 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04921516 0,08268434 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04921516 0,08262399 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04921516 0,08256372 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04921516 0,08250355 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,04921516 0,08244346 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,04921516 0,08238345 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04921516 0,08232354 ! lysogeny GO:0030069 18 11 0,000 0,04921516 0,08226371 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04921516 0,08220397 ! acrosome reaction GO:0007340 13 11 0,000 0,04921516 0,08214431 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04921516 0,08208475 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,04966221 0,08277034 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,05080449 0,08461283 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,05195623 0,0864684 GO:0010498|proteasomal protein catabolic process, ! mRNA transport GO:0051028 121 81 1,000 0,05311732 0,08833683 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,05311732 0,088273 ! response to protein stimulus GO:0051789 111 81 1,000 0,05311732 0,08820927 ! lactation GO:0007595 20 12 0,000 0,05356882 0,08889487 ! reproductive cellular process GO:0048610 14 12 0,000 0,05356882 0,08883077 ! tRNA modification GO:0006400 14 12 0,000 0,05356882 0,08876677 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05356882 0,08870287 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05356882 0,08863905 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05356882 0,08857533 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05356882 0,0885117 ! non-recombinational repair GO:0000726 19 12 0,000 0,05356882 0,08844816 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05356882 0,08838471 ! peroxisomal transport GO:0043574 21 12 0,000 0,05356882 0,08832135 ! cartilage condensation GO:0001502 18 12 0,000 0,05356882 0,08825808 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05356882 0,08819491 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05356882 0,08813182 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05356882 0,08806882 ! heart looping GO:0001947 15 12 0,000 0,05356882 0,08800592 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05356882 0,0879431 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05356882 0,08788037 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05356882 0,08781774 ! arginine metabolic process GO:0006525 13 12 0,000 0,05356882 0,08775519 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05356882 0,08769273 ! methionine metabolic process GO:0006555 13 12 0,000 0,05356882 0,08763036 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05356882 0,08756808 ! Golgi organization GO:0007030 18 12 0,000 0,05356882 0,08750588 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05356882 0,08744378 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05356882 0,08738176 ! monoamine transport GO:0015844 13 12 0,000 0,05356882 0,08731983 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05356882 0,08725799 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05356882 0,08719624 ! L-amino acid transport GO:0015807 20 12 0,000 0,05356882 0,08713457 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05356882 0,08707299 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05356882 0,0870115 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05356882 0,08695009 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05356882 0,08688878 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05356882 0,08682754 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05356882 0,0867664 ! cerebellum development GO:0021549 13 12 0,000 0,05356882 0,08670534 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05356882 0,08664436 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05356882 0,08658347 ! histone methylation GO:0016571 15 12 0,000 0,05356882 0,08652267 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05356882 0,08646195 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05356882 0,08640132 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05356882 0,08634077 ! intestinal absorption GO:0050892 19 12 0,000 0,05356882 0,08628031 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05356882 0,08621993 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05356882 0,08615964 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,05356882 0,08609943 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05356882 0,0860393 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,05356882 0,08597926 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05356882 0,0859193 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05356882 0,08585943 ! microspike assembly GO:0030035 23 12 0,000 0,05356882 0,08579964 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05356882 0,08573993 ! response to cold GO:0009409 14 12 0,000 0,05356882 0,08568031 ! ossification GO:0001503 134 82 1,000 0,05428766 0,08676971 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,05428766 0,08670945 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,05546713 0,08853185 ! transcription initiation GO:0006352 118 85 1,000 0,05785307 0,09227604 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,05785307 0,0922121 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,05790279 0,09222744 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05790279 0,09216361 ! cGMP metabolic process GO:0046068 16 13 0,000 0,05790279 0,09209987 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,05790279 0,09203623 ! water transport GO:0006833 17 13 0,000 0,05790279 0,09197267 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05790279 0,09190919 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05790279 0,09184581 ! lipid localization GO:0010876 24 13 0,000 0,05790279 0,09178251 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,05790279 0,0917193 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,05790279 0,09165617 ! organelle fusion GO:0048284 28 13 0,000 0,05790279 0,09159314 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05790279 0,09153018 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,05790279 0,09146732 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05790279 0,09140454 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05790279 0,09134185 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05790279 0,09127925 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05790279 0,09121673 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05790279 0,09115429 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05790279 0,09109194 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05790279 0,09102968 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05790279 0,0909675 ! NAD metabolic process GO:0019674 21 13 0,000 0,05790279 0,09090541 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,05790279 0,0908434 ! bone mineralization GO:0030282 15 13 0,000 0,05790279 0,09078147 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05790279 0,09071963 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,05790279 0,09065788 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05790279 0,0905962 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05790279 0,09053462 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05790279 0,09047311 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,05790279 0,09041169 ! genitalia development GO:0048806 15 13 0,000 0,05790279 0,09035035 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,05790279 0,0902891 ! cellular pigmentation GO:0033059 24 13 0,000 0,05790279 0,09022793 ! tissue regeneration GO:0042246 21 13 0,000 0,05790279 0,09016684 ! cofactor transport GO:0051181 19 13 0,000 0,05790279 0,09010583 ! NADP metabolic process GO:0006739 18 13 0,000 0,05790279 0,09004491 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05790279 0,08998407 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05790279 0,08992331 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05790279 0,08986263 ! gas transport GO:0015669 18 13 0,000 0,05790279 0,08980204 ! regulation of RNA stability GO:0043487 28 13 0,000 0,05790279 0,08974152 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05790279 0,08968109 ! regulation of axon extension GO:0030516 23 13 0,000 0,05790279 0,08962074 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05790279 0,08956047 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05790279 0,08950028 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05790279 0,08944017 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,05790279 0,08938015 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05790279 0,0893202 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,0602743 0,09291614 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,0602743 0,0928539 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,06149788 0,09467546 ! establishment of RNA localization GO:0051236 128 88 1,000 0,06149788 0,09461213 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,06221716 0,09565473 ! superoxide anion generation GO:0042554 18 14 0,000 0,06221716 0,09559083 ! neuron maturation GO:0042551 21 14 0,000 0,06221716 0,09552702 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,06221716 0,09546329 ! myotube differentiation GO:0014902 21 14 0,000 0,06221716 0,09539965 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,06221716 0,09533609 ! inositol metabolic process GO:0006020 20 14 0,000 0,06221716 0,09527262 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,06221716 0,09520923 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,06221716 0,09514593 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,06221716 0,09508271 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,06221716 0,09501957 ! gene silencing by RNA GO:0031047 20 14 0,000 0,06221716 0,09495652 ! response to cAMP GO:0051591 19 14 0,000 0,06221716 0,09489355 ! limbic system development GO:0021761 25 14 0,000 0,06221716 0,09483067 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,06221716 0,09476787 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,06221716 0,09470515 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,06221716 0,09464251 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,06221716 0,09457996 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,06221716 0,09451749 ! glycine metabolic process GO:0006544 22 14 0,000 0,06221716 0,0944551 ! pituitary gland development GO:0021983 23 14 0,000 0,06221716 0,09439279 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,06221716 0,09433057 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,06221716 0,09426843 ! regulation of heart rate GO:0002027 23 14 0,000 0,06221716 0,09420637 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,06221716 0,09414439 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,06221716 0,0940825 ! embryo implantation GO:0007566 27 14 0,000 0,06221716 0,09402068 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,06221716 0,09395895 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,06221716 0,09389729 ! axon cargo transport GO:0008088 27 14 0,000 0,06221716 0,09383572 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,06221716 0,09377423 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,06221716 0,09371282 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06221716 0,09365149 ! mRNA splice site selection GO:0006376 26 14 0,000 0,06221716 0,09359024 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,06221716 0,09352907 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,06221716 0,09346798 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,06221716 0,09340697 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,06221716 0,09334604 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,06221716 0,09328519 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,06221716 0,09322441 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,06221716 0,09316372 ! muscle maintenance GO:0046716 19 14 0,000 0,06221716 0,09310311 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,06221716 0,09304257 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,06221716 0,09298212 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,06221716 0,09292174 ! cell killing GO:0001906 20 14 0,000 0,06221716 0,09286144 ! cilium assembly GO:0042384 20 14 0,000 0,06221716 0,09280122 ! peptide hormone secretion GO:0030072 23 14 0,000 0,06221716 0,09274107 ! reproductive developmental process GO:0003006 127 89 1,000 0,06272999 0,09344493 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,06272999 0,09338445 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,06397051 0,09516958 ! RNA localization GO:0006403 135 91 1,000 0,06521934 0,09696475 ! ATP metabolic process GO:0046034 137 91 1,000 0,06521934 0,09690211 ! response to virus GO:0009615 122 91 1,000 0,06521934 0,09683956 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,06647638 0,09864237 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,06651202 0,09863163 ! metencephalon development GO:0022037 19 15 0,000 0,06651202 0,09856808 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,06651202 0,09850461 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,06651202 0,09844122 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,06651202 0,09837791 ! skin development GO:0043588 25 15 0,000 0,06651202 0,09831469 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,06651202 0,09825155 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,06651202 0,09818848 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,06651202 0,0981255 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,06651202 0,0980626 ! bile acid metabolic process GO:0008206 22 15 0,000 0,06651202 0,09799978 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,06651202 0,09793704 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,06651202 0,09787438 ! adult walking behavior GO:0007628 25 15 0,000 0,06651202 0,0978118 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,06651202 0,0977493 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,06651202 0,09768688 ! centrosome cycle GO:0007098 16 15 0,000 0,06651202 0,09762454 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,06651202 0,09756228 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,06651202 0,0975001 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,06651202 0,097438 ! cerebral cortex development GO:0021987 29 15 0,000 0,06651202 0,09737597 ! response to osmotic stress GO:0006970 22 15 0,000 0,06651202 0,09731403 ! vesicle coating GO:0006901 25 15 0,000 0,06651202 0,09725217 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,06651202 0,09719038 ! DNA integration GO:0015074 22 15 0,000 0,06651202 0,09712867 ! peptide secretion GO:0002790 27 15 0,000 0,06651202 0,09706704 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,06651202 0,09700549 ! regulation of vasodilation GO:0042312 24 15 0,000 0,06651202 0,09694402 ! neuron recognition GO:0008038 22 15 0,000 0,06651202 0,09688262 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,06651202 0,0968213 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,06651202 0,09676006 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,06651202 0,0966989 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,06651202 0,09663781 ! biomineral formation GO:0031214 18 15 0,000 0,06651202 0,0965768 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,06651202 0,09651587 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,06651202 0,09645502 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,06651202 0,09639424 ! organic cation transport GO:0015695 19 15 0,000 0,06651202 0,09633354 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,06651202 0,09627291 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,06651202 0,09621236 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 19 15 0,000 0,06651202 0,09615189 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,06651202 0,09609149 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,06774153 0,09780636 ! response to oxidative stress GO:0006979 141 94 1,000 0,0690147 0,09958207 ! regulation of binding GO:0051098 151 95 1,000 0,07029579 0,10136697 ! protein secretion GO:0009306 27 16 0,000 0,07078746 0,102012 ! hormone secretion GO:0046879 25 16 0,000 0,07078746 0,10194813 ! endothelial cell migration GO:0043542 22 16 0,000 0,07078746 0,10188433 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,07078746 0,10182061 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07078746 0,10175697 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,07078746 0,10169342 ! glial cell development GO:0021782 24 16 0,000 0,07078746 0,10162994 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,07078746 0,10156654 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,07078746 0,10150322 ! protein polyubiquitination GO:0000209 26 16 0,000 0,07078746 0,10143997 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,07078746 0,10137681 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,07078746 0,10131373 ! fructose metabolic process GO:0006000 20 16 0,000 0,07078746 0,10125072 ! regulation of protein binding GO:0043393 27 16 0,000 0,07078746 0,10118779 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,07078746 0,10112494 ! protein export from nucleus GO:0006611 24 16 0,000 0,07078746 0,10106217 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,07078746 0,10099948 ! DNA replication initiation GO:0006270 25 16 0,000 0,07078746 0,10093686 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,07078746 0,10087432 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,07078746 0,10081186 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,07078746 0,10074948 ! diencephalon development GO:0021536 25 16 0,000 0,07078746 0,10068717 ! oogenesis GO:0048477 23 16 0,000 0,07078746 0,10062494 ! neural crest cell migration GO:0001755 24 16 0,000 0,07078746 0,10056279 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,07078746 0,10050072 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,07078746 0,10043872 ! steroid catabolic process GO:0006706 22 16 0,000 0,07078746 0,10037679 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,07078746 0,10031495 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,07078746 0,10025318 ! sperm-egg recognition GO:0035036 16 16 0,000 0,07078746 0,10019148 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,07078746 0,10012986 ! nerve development GO:0021675 18 16 0,000 0,07078746 0,10006832 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,07078746 0,10000685 ! negative regulation of translation GO:0017148 22 16 0,000 0,07078746 0,09994546 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,0715847 0,10100909 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,0715847 0,10094715 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,0715847 0,1008853 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,07288133 0,10264976 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,07504356 0,10563047 ! negative regulation of defense response GO:0031348 19 17 0,000 0,07504356 0,10556586 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,07504356 0,10550133 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,07504356 0,10543689 ! glycerol metabolic process GO:0006071 20 17 0,000 0,07504356 0,10537252 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,07504356 0,10530823 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,07504356 0,10524401 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,07504356 0,10517988 ! signal complex assembly GO:0007172 29 17 0,000 0,07504356 0,10511582 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,07504356 0,10505185 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,07504356 0,10498795 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,07504356 0,10492412 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,07504356 0,10486038 ! memory GO:0007613 25 17 0,000 0,07504356 0,10479671 ! keratinization GO:0031424 17 17 0,000 0,07504356 0,10473312 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,07504356 0,10466961 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,07504356 0,10460617 ! retinoid metabolic process GO:0001523 22 17 0,000 0,07504356 0,10454281 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,07504356 0,10447953 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,07504356 0,10441632 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,07504356 0,10435319 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,07504356 0,10429014 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,07504356 0,10422716 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,07504356 0,10416426 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,07504356 0,10410144 ! membrane budding GO:0006900 29 17 0,000 0,07504356 0,10403869 ! heme metabolic process GO:0042168 27 17 0,000 0,07504356 0,10397601 ! neuromuscular junction development GO:0007528 23 17 0,000 0,07504356 0,10391342 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,07504356 0,10385089 ! body fluid secretion GO:0007589 27 17 0,000 0,07504356 0,10378844 ! stem cell differentiation GO:0048863 36 17 0,000 0,07504356 0,10372607 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,07504356 0,10366377 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,07504356 0,10360155 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,07504356 0,1035394 ! sensory perception of pain GO:0019233 23 17 0,000 0,07504356 0,10347733 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,07504356 0,10341533 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,07504356 0,1033534 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,07504356 0,10329155 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,07504356 0,10322977 ! cell-cell junction organization GO:0045216 25 17 0,000 0,07504356 0,10316807 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,07504356 0,10310644 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,07504356 0,10304489 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,07504356 0,1029834 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,07504356 0,10292199 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,07549739 0,10348271 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,07681662 0,10522825 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,07681662 0,10516561 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,0792804 0,10847408 ! positive regulation of translation GO:0045727 28 18 0,000 0,0792804 0,10840959 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,0792804 0,10834517 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,0792804 0,10828084 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,0792804 0,10821658 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,0792804 0,10815239 ! cAMP metabolic process GO:0046058 33 18 0,000 0,0792804 0,10808828 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,0792804 0,10802425 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,0792804 0,10796029 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,0792804 0,10789641 ! axis specification GO:0009798 26 18 0,000 0,0792804 0,1078326 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,0792804 0,10776887 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,0792804 0,10770521 ! pancreas development GO:0031016 26 18 0,000 0,0792804 0,10764163 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,0792804 0,10757813 ! glutamine metabolic process GO:0006541 23 18 0,000 0,0792804 0,1075147 ! response to retinoic acid GO:0032526 25 18 0,000 0,0792804 0,10745134 ! central nervous system neuron development GO:0021954 30 18 0,000 0,0792804 0,10738806 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,0792804 0,10732486 ! fucose metabolic process GO:0006004 26 18 0,000 0,0792804 0,10726172 ! response to fungus GO:0009620 19 18 0,000 0,0792804 0,10719866 ! peptide cross-linking GO:0018149 31 18 0,000 0,0792804 0,10713568 ! heart process GO:0003015 27 18 0,000 0,0792804 0,10707277 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,0792804 0,10700993 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,0792804 0,10694717 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,0792804 0,10688448 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,0792804 0,10682187 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,0792804 0,10675933 ! vitamin transport GO:0051180 24 18 0,000 0,0792804 0,10669686 ! hormone transport GO:0009914 27 18 0,000 0,0792804 0,10663446 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,0792804 0,10657214 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,0792804 0,10650989 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,0792804 0,10644771 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,0792804 0,10638561 ! cell-cell recognition GO:0009988 20 18 0,000 0,0792804 0,10632357 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,0792804 0,10626161 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,0792804 0,10619973 ! regulation of glucose import GO:0046324 21 18 0,000 0,0792804 0,10613791 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,0792804 0,10607617 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,0792804 0,10601449 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,0792804 0,10595289 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,08349808 0,11152473 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,08349808 0,11146001 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,08349808 0,11139536 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,08349808 0,11133078 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,08349808 0,11126628 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,08349808 0,11120185 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,08349808 0,1111375 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,08349808 0,11107322 ! regeneration GO:0031099 32 19 0,000 0,08349808 0,11100901 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,08349808 0,11094488 ! sensory perception of taste GO:0050909 23 19 0,000 0,08349808 0,11088083 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,08349808 0,11081685 ! smooth muscle contraction GO:0006939 36 19 0,000 0,08349808 0,11075294 ! peroxisome organization GO:0007031 29 19 0,000 0,08349808 0,1106891 ! digestive system process GO:0022600 30 19 0,000 0,08349808 0,11062534 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,08349808 0,11056165 ! response to vitamin A GO:0033189 26 19 0,000 0,08349808 0,11049804 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,08349808 0,1104345 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,08349808 0,11037103 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,08349808 0,11030764 ! plasma membrane fusion GO:0045026 23 19 0,000 0,08349808 0,11024431 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,08349808 0,11018106 ! cytolysis GO:0019835 20 19 0,000 0,08349808 0,11011789 ! renal system process GO:0003014 35 19 0,000 0,08349808 0,11005478 ! vasodilation GO:0042311 33 19 0,000 0,08349808 0,10999175 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,08349808 0,10992879 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,08349808 0,1098659 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,08349808 0,10980308 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,08349808 0,10974034 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,08349808 0,10967767 ! sarcomere organization GO:0045214 23 19 0,000 0,08349808 0,10961506 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,08349808 0,10955253 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,08349808 0,10949008 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,08349808 0,10942769 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,08349808 0,10936537 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,08349808 0,10930313 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,08349808 0,10924095 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,08349808 0,10917885 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,08349808 0,10911681 ! protein stabilization GO:0050821 26 19 0,000 0,08349808 0,10905485 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,08769668 0,11447354 ! iron ion transport GO:0006826 37 20 0,000 0,08769668 0,11440861 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,08769668 0,11434375 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,08769668 0,11427897 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,08769668 0,11421425 ! response to vitamin GO:0033273 29 20 0,000 0,08769668 0,11414962 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,08769668 0,11408505 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,08769668 0,11402056 ! spinal cord development GO:0021510 31 20 0,000 0,08769668 0,11395614 ! response to ethanol GO:0045471 37 20 0,000 0,08769668 0,1138918 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,08769668 0,11382752 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,08769668 0,11376332 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,08769668 0,1136992 ! chromosome condensation GO:0030261 31 20 0,000 0,08769668 0,11363514 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,08769668 0,11357116 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,08769668 0,11350724 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,08769668 0,1134434 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,08769668 0,11337964 ! pallium development GO:0021543 38 20 0,000 0,08769668 0,11331594 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,08769668 0,11325232 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,08769668 0,11318876 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,08769668 0,11312528 ! collagen catabolic process GO:0030574 25 20 0,000 0,08769668 0,11306187 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,08769668 0,11299853 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,08769668 0,11293526 ! alditol metabolic process GO:0019400 24 20 0,000 0,08769668 0,11287206 ! actin filament-based movement GO:0030048 34 20 0,000 0,08769668 0,11280893 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,09187629 0,11811932 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,09187629 0,11805333 GO:0016444|somatic cell DNA recombination, ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,09187629 0,11798742 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,09187629 0,11792158 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,09187629 0,11785581 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,09187629 0,11779011 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,09187629 0,11772449 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,09187629 0,11765895 ! vesicle docking GO:0048278 27 21 0,000 0,09187629 0,11759347 ! phototransduction GO:0007602 25 21 0,000 0,09187629 0,11752807 ! dendrite development GO:0016358 35 21 0,000 0,09187629 0,11746274 ! visual behavior GO:0007632 39 21 0,000 0,09187629 0,11739748 ! ovarian follicle development GO:0001541 30 21 0,000 0,09187629 0,1173323 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,09187629 0,11726718 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,09187629 0,11720214 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,09187629 0,11713718 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,09187629 0,11707228 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,09187629 0,11700746 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,09187629 0,1169427 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,09187629 0,11687802 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,09187629 0,11681341 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,09187629 0,11674888 ! fatty acid transport GO:0015908 30 21 0,000 0,09187629 0,11668441 ! platelet activation GO:0030168 28 21 0,000 0,09187629 0,11662001 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,09187629 0,11655569 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,09187629 0,11649144 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,09187629 0,11642725 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,09187629 0,11636314 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,09187629 0,1162991 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,09187629 0,11623513 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,09187629 0,11617123 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,09187629 0,1161074 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,09187629 0,11604364 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,09187629 0,11597995 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,09187629 0,11591633 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,09603698 0,12109927 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,09603698 0,12103291 ! viral genome replication GO:0019079 29 22 0,000 0,09603698 0,12096663 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,09603698 0,12090042 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,09603698 0,12083428 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,09603698 0,12076821 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,09603698 0,12070222 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,09603698 0,1206363 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,09603698 0,12057045 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,09603698 0,12050467 GO:0010810|regulation of cell-substrate adhesion, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,09603698 0,12043897 ! lysosome organization GO:0007040 37 22 0,000 0,09603698 0,12037333 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,09603698 0,12030777 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,09603698 0,12024228 ! regulation of behavior GO:0050795 38 22 0,000 0,09603698 0,12017686 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,09603698 0,12011151 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,09603698 0,12004623 ! membrane depolarization GO:0051899 35 22 0,000 0,09603698 0,11998102 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,09603698 0,11991589 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,09603698 0,11985082 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,09603698 0,11978583 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,09603698 0,1197209 ! blastocyst development GO:0001824 37 22 0,000 0,09603698 0,11965605 ! neural tube closure GO:0001843 33 22 0,000 0,09603698 0,11959126 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,09603698 0,11952655 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,10017885 0,12461404 ! neuron fate commitment GO:0048663 32 23 0,000 0,10017885 0,12454668 ! embryonic pattern specification GO:0009880 31 23 0,000 0,10017885 0,1244794 ! myelination GO:0042552 35 23 0,000 0,10017885 0,12441218 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,10017885 0,12434504 ! vesicle targeting GO:0006903 32 23 0,000 0,10017885 0,12427797 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,10017885 0,12421098 ! osteoblast differentiation GO:0001649 40 23 0,000 0,10017885 0,12414405 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,10017885 0,1240772 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,10017885 0,12401042 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,10017885 0,12394371 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,10017885 0,12387708 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,10017885 0,12381051 ! cell fate determination GO:0001709 45 23 0,000 0,10017885 0,12374402 ! pentose metabolic process GO:0019321 31 23 0,000 0,10017885 0,1236776 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,10017885 0,12361125 ! spermatid development GO:0007286 33 23 0,000 0,10017885 0,12354497 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,10017885 0,12347876 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,10017885 0,12341262 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,10017885 0,12334655 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,10017885 0,12328056 ! telomere organization GO:0032200 32 23 0,000 0,10017885 0,12321463 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,10017885 0,12314878 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,10017885 0,12308299 ! regulation of amine transport GO:0051952 38 23 0,000 0,10017885 0,12301728 ! liver development GO:0001889 40 23 0,000 0,10017885 0,12295164 ! initiation of viral infection GO:0019059 42 24 0,000 0,10430198 0,12794376 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,10430198 0,12787556 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,10430198 0,12780744 ! superoxide metabolic process GO:0006801 32 24 0,000 0,10430198 0,12773938 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,10430198 0,1276714 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,10430198 0,12760349 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,10430198 0,12753565 ! sperm motility GO:0030317 27 24 0,000 0,10430198 0,12746788 ! vacuole organization GO:0007033 39 24 0,000 0,10430198 0,12740019 ! receptor metabolic process GO:0043112 37 24 0,000 0,10430198 0,12733257 ! neural crest cell development GO:0014032 39 24 0,000 0,10430198 0,12726502 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,10430198 0,12719754 ! primary neural tube formation GO:0014020 35 24 0,000 0,10430198 0,12713013 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,10430198 0,1270628 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,10430198 0,12699553 ! glutathione metabolic process GO:0006749 29 24 0,000 0,10430198 0,12692834 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,10430198 0,12686122 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,10430198 0,12679416 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,10840645 0,13171413 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,10840645 0,13164458 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,10840645 0,13157511 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,10840645 0,13150572 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,10840645 0,13143639 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,10840645 0,13136714 ! peptide transport GO:0015833 43 25 0,000 0,10840645 0,13129797 ! male gonad development GO:0008584 33 25 0,000 0,10840645 0,13122886 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,10840645 0,13115983 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,10840645 0,13109087 ! phospholipid transport GO:0015914 35 25 0,000 0,10840645 0,13102199 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,10840645 0,13095317 ! detection of light stimulus GO:0009583 30 25 0,000 0,10840645 0,13088443 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,10840645 0,13081576 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,10840645 0,13074716 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,11249235 0,13560398 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,11249235 0,13553295 ! translational initiation GO:0006413 43 26 0,000 0,11249235 0,13546199 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,11249235 0,1353911 ! circadian rhythm GO:0007623 42 26 0,000 0,11249235 0,13532029 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,11249235 0,13524956 ! post-embryonic development GO:0009791 42 26 0,000 0,11249235 0,13517889 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,11249235 0,1351083 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,11249235 0,13503779 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,11249235 0,13496735 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,11249235 0,13489698 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,11249235 0,13482668 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,11249235 0,13475646 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,11249235 0,13468631 ! regulation of coagulation GO:0050818 39 26 0,000 0,11249235 0,13461623 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,11655975 0,13941104 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,11655975 0,13933858 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,11655975 0,1392662 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,11655975 0,13919389 ! membrane docking GO:0022406 39 27 0,000 0,11655975 0,13912166 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,11655975 0,1390495 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,11655975 0,13897741 ! acute-phase response GO:0006953 42 27 0,000 0,11655975 0,1389054 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,11655975 0,13883347 ! myofibril assembly GO:0030239 36 27 0,000 0,11655975 0,13876161 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,11655975 0,13868982 ! natural killer cell activation GO:0030101 35 27 0,000 0,11655975 0,13861811 ! lipid oxidation GO:0034440 38 27 0,000 0,11655975 0,13854648 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,11655975 0,13847491 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,11655975 0,13840342 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,11655975 0,13833201 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,11655975 0,13826067 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,11655975 0,1381894 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,11655975 0,1381182 ! gene silencing GO:0016458 41 27 0,000 0,11655975 0,13804708 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,12060875 0,14276898 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,12060875 0,14269554 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,12060875 0,14262217 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,12060875 0,14254888 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,12060875 0,14247567 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,12060875 0,14240253 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,12060875 0,14232946 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,12060875 0,14225647 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,12060875 0,14218356 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,12060875 0,14211072 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,12060875 0,14203795 ! response to organic cyclic substance GO:0014070 47 28 0,000 0,12060875 0,14196526 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,12060875 0,14189264 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,12060875 0,1418201 ! mesoderm formation GO:0001707 46 28 0,000 0,12060875 0,14174763 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,12060875 0,14167524 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,12060875 0,14160292 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,12060875 0,14153067 ! ensheathment of neurons GO:0007272 43 28 0,000 0,12060875 0,1414585 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,12060875 0,1413864 ! placenta development GO:0001890 37 28 0,000 0,12060875 0,14131438 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,12463942 0,14596266 ! regulation of innate immune response GO:0045088 38 29 0,000 0,12463942 0,14588838 ! ovulation cycle process GO:0022602 41 29 0,000 0,12463942 0,14581417 ! protein targeting to membrane GO:0006612 53 29 0,000 0,12463942 0,14574004 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,12463942 0,14566599 ! mismatch repair GO:0006298 34 29 0,000 0,12463942 0,14559201 ! muscle cell development GO:0055001 38 29 0,000 0,12463942 0,1455181 ! formation of primary germ layer GO:0001704 48 29 0,000 0,12463942 0,14544427 ! telencephalon development GO:0021537 52 29 0,000 0,12463942 0,14537052 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,12463942 0,14529684 ! eye morphogenesis GO:0048592 51 29 0,000 0,12463942 0,14522323 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,12463942 0,1451497 ! tissue homeostasis GO:0001894 42 29 0,000 0,12463942 0,14507624 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,12865184 0,14967083 ! collagen metabolic process GO:0032963 40 30 0,000 0,12865184 0,14959517 ! organic anion transport GO:0015711 51 30 0,000 0,12865184 0,14951957 ! cholesterol transport GO:0030301 46 30 0,000 0,12865184 0,14944406 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,12865184 0,14936862 ! spindle organization GO:0007051 37 30 0,000 0,12865184 0,14929326 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,12865184 0,14921797 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,12865184 0,14914276 ! ceramide metabolic process GO:0006672 43 30 0,000 0,12865184 0,14906763 ! ovulation cycle GO:0042698 43 30 0,000 0,12865184 0,14899257 ! hindbrain development GO:0030902 45 30 0,000 0,12865184 0,14891758 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,12865184 0,14884267 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,12865184 0,14876784 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,12865184 0,14869308 ! response to heat GO:0009408 41 30 0,000 0,12865184 0,1486184 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,12865184 0,14854379 ! negative regulation of secretion GO:0051048 49 31 0,000 0,1326461 0,15307879 ! glial cell differentiation GO:0010001 55 31 0,000 0,1326461 0,15300203 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,1326461 0,15292533 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,1326461 0,15284872 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,1326461 0,15277218 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,1326461 0,15269571 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,1326461 0,15261933 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,1326461 0,15254302 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,1326461 0,15246679 ! cell fate specification GO:0001708 37 31 0,000 0,1326461 0,15239063 ! RNA modification GO:0009451 40 31 0,000 0,1326461 0,15231455 ! regulation of muscle development GO:0048634 48 32 0,000 0,13662228 0,15680202 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,13662228 0,15672382 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,13662228 0,15664569 ! meiosis I GO:0007127 52 32 0,000 0,13662228 0,15656764 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,13662228 0,15648967 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,13662228 0,15641177 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,13662228 0,15633396 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,13662228 0,15625622 ! regulation of protein stability GO:0031647 48 32 0,000 0,13662228 0,15617855 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,13662228 0,15610097 ! cytokine production GO:0001816 44 32 0,000 0,13662228 0,15602346 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,13662228 0,15594603 ! vesicle localization GO:0051648 47 32 0,000 0,13662228 0,15586868 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,14058046 0,16030494 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,14058046 0,1602255 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,14058046 0,16014614 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,14058046 0,16006686 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,14058046 0,15998766 ! sister chromatid segregation GO:0000819 46 33 0,000 0,14058046 0,15990854 ! actomyosin structure organization GO:0031032 43 33 0,000 0,14058046 0,15982949 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,14058046 0,15975052 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,14058046 0,15967164 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,14058046 0,15959282 ! female gonad development GO:0008585 49 33 0,000 0,14058046 0,15951409 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,14058046 0,15943544 ! lipid homeostasis GO:0055088 55 33 0,000 0,14058046 0,15935686 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,14058046 0,15927836 ! regulation of proteolysis GO:0030162 50 33 0,000 0,14058046 0,15919993 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,14058046 0,15912159 ! cytokinesis GO:0000910 52 33 0,000 0,14058046 0,15904332 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,14058046 0,15896512 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,14452072 0,16334037 ! mRNA catabolic process GO:0006402 48 34 0,000 0,14452072 0,16326015 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,14452072 0,16318 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,14452072 0,16309993 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,14452072 0,16301994 ! feeding behavior GO:0007631 45 34 0,000 0,14452072 0,16294003 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,14452072 0,16286019 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,14452072 0,16278044 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,14452072 0,16270076 ! neuron migration GO:0001764 46 34 0,000 0,14452072 0,16262116 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,14452072 0,16254164 ! female gamete generation GO:0007292 43 34 0,000 0,14452072 0,1624622 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,14452072 0,16238283 ! polyol metabolic process GO:0019751 44 34 0,000 0,14452072 0,16230354 ! aerobic respiration GO:0009060 47 34 0,000 0,14452072 0,16222433 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,14844314 0,16654596 ! Notch signaling pathway GO:0007219 56 35 0,000 0,14844314 0,16646476 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,14844314 0,16638363 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,14844314 0,16630259 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,14844314 0,16622162 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,14844314 0,16614074 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,14844314 0,16605993 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,14844314 0,1659792 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,14844314 0,16589855 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,14844314 0,16581798 ! pigment metabolic process GO:0042440 61 35 0,000 0,14844314 0,16573748 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,15234779 0,17001452 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,15234779 0,16993207 ! negative regulation of binding GO:0051100 58 36 0,000 0,15234779 0,1698497 ! organic ether metabolic process GO:0018904 46 36 0,000 0,15234779 0,16976741 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,15234779 0,16968519 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,15234779 0,16960306 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,15234779 0,16952101 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,15234779 0,16943904 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,15623477 0,17367809 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,15623477 0,17359419 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,15623477 0,17351037 ! learning GO:0007612 67 37 0,000 0,15623477 0,17342663 ! ion transmembrane transport GO:0034220 56 37 0,000 0,15623477 0,17334297 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,15623477 0,17325939 ! regulation of protein secretion GO:0050708 51 37 0,000 0,15623477 0,17317589 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,15623477 0,17309247 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,16010414 0,17729395 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,16010414 0,17720863 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,16010414 0,17712339 ! phagocytosis GO:0006909 60 38 0,000 0,16010414 0,17703824 ! maintenance of location in cell GO:0051651 69 38 0,000 0,16010414 0,17695316 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,16395599 0,18112334 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,16395599 0,18103638 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,16395599 0,18094951 ! male sex differentiation GO:0046661 53 39 0,000 0,16395599 0,18086273 ! chromatin remodeling GO:0006338 68 39 0,000 0,16395599 0,18077602 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,16395599 0,1806894 ! JNK cascade GO:0007254 54 39 0,000 0,16395599 0,18060287 ! developmental growth GO:0048589 62 39 0,000 0,16395599 0,18051641 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,1677904 0,18464972 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,1677904 0,18456141 ! regulation of tube size GO:0035150 60 40 0,000 0,1677904 0,18447319 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,1677904 0,18438505 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,1677904 0,184297 ! peptide metabolic process GO:0006518 56 40 0,000 0,1677904 0,18420903 ! inner ear development GO:0048839 57 40 0,000 0,1677904 0,18412114 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,1677904 0,18403334 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,1677904 0,18394562 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,1677904 0,18385799 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,1677904 0,18377044 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,17160744 0,18786154 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,17160744 0,18777217 ! endosome transport GO:0016197 71 41 0,000 0,17160744 0,18768288 ! striated muscle contraction GO:0006941 62 41 0,000 0,17160744 0,18759368 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,17160744 0,18750456 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,17540718 0,1915653 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,17540718 0,19147438 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,17540718 0,19138355 ! excretion GO:0007588 63 42 0,000 0,17540718 0,1912928 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,17540718 0,19120214 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,17540718 0,19111157 ! regulation of cell shape GO:0008360 78 42 0,000 0,17540718 0,19102108 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,17918972 0,19504797 ! tRNA processing GO:0008033 49 43 0,000 0,17918972 0,1949557 ! vesicle organization GO:0016050 79 43 0,000 0,17918972 0,19486352 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,18295512 0,19886426 ! glycolysis GO:0006096 53 44 0,000 0,18295512 0,19877032 ! regulation of action potential GO:0001508 71 44 0,000 0,18295512 0,19867648 ! regulation of ion transport GO:0043269 57 44 0,000 0,18295512 0,19858272 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,18295512 0,19848905 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,18295512 0,19839546 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,18295512 0,19830197 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,18295512 0,19820856 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,18295512 0,19811524 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,18295512 0,19802201 ! RNA catabolic process GO:0006401 64 45 0,000 0,18670346 0,20198399 ! positive regulation of defense response GO:0031349 59 45 0,000 0,18670346 0,20188903 ! regulation of translational initiation GO:0006446 64 45 0,000 0,18670346 0,20179416 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,18670346 0,20169937 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,18670346 0,20160468 ! cell recognition GO:0008037 58 45 0,000 0,18670346 0,20151007 ! cell maturation GO:0048469 60 45 0,000 0,18670346 0,20141555 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,19043482 0,20534463 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,19043482 0,2052484 ! cell redox homeostasis GO:0045454 63 46 0,000 0,19043482 0,20515227 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,19043482 0,20505622 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,19414928 0,20895804 ! viral infectious cycle GO:0019058 71 47 0,000 0,19414928 0,20886031 ! endocrine system development GO:0035270 83 47 0,000 0,19414928 0,20876266 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,19414928 0,20866511 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,19414928 0,20856765 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,19414928 0,20847028 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,19414928 0,208373 ! chloride transport GO:0006821 67 48 0,000 0,1978469 0,21224248 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,1978469 0,21214353 ! response to temperature stimulus GO:0009266 62 48 0,000 0,1978469 0,21204467 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,1978469 0,21194591 ! gastrulation GO:0007369 73 48 0,000 0,1978469 0,21184724 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,1978469 0,21174866 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,1978469 0,21165017 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,1978469 0,21155177 ! regulation of endocytosis GO:0030100 63 48 0,000 0,1978469 0,21145347 ! nuclear export GO:0051168 69 48 0,000 0,1978469 0,21135526 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,1978469 0,21125713 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,20152777 0,21508764 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,20152777 0,21498788 ! sensory perception of smell GO:0007608 61 49 0,000 0,20152777 0,21488821 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,20152777 0,21478863 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,20152777 0,21468914 ! RNA elongation GO:0006354 62 49 0,000 0,20152777 0,21458975 ! germ cell development GO:0007281 68 49 0,000 0,20152777 0,21449045 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,20152777 0,21439124 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,20152777 0,21429212 ! maintenance of location GO:0051235 84 49 0,000 0,20152777 0,2141931 ! regulation of actin filament length GO:0030832 72 50 0,000 0,20519195 0,21798683 ! membrane fusion GO:0006944 80 50 0,000 0,20519195 0,21788619 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,20519195 0,21778565 ! proton transport GO:0015992 75 50 0,000 0,20519195 0,21768519 ! positive regulation of secretion GO:0051047 71 51 0,000 0,20883954 0,22145271 ! hydrogen transport GO:0006818 77 51 0,000 0,20883954 0,22135066 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,20883954 0,2212487 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,20883954 0,22114684 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,20883954 0,22104507 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,20883954 0,22094339 ! transition metal ion transport GO:0000041 74 52 0,000 0,21247059 0,22468154 ! regulation of cellular component size GO:0032535 74 52 0,000 0,21247059 0,22457828 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,21247059 0,22447513 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,21247059 0,22437206 ! establishment of organelle localization GO:0051656 85 52 0,000 0,21247059 0,22426909 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,21608518 0,22797978 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,21608518 0,22787525 ! single fertilization GO:0007338 59 53 0,000 0,21608518 0,22777081 ! cell projection assembly GO:0030031 76 53 0,000 0,21608518 0,22766647 ! amino acid transport GO:0006865 84 54 0,000 0,21968339 0,23135155 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,21968339 0,23124567 ! regulation of mitosis GO:0007088 84 54 0,000 0,21968339 0,23113989 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,21968339 0,2310342 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,21968339 0,23092861 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,21968339 0,23082311 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,21968339 0,23071771 ! exocytosis GO:0006887 74 55 0,000 0,22326529 0,23437251 ! mesoderm development GO:0007498 76 55 0,000 0,22326529 0,23426558 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,22326529 0,23415876 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,22326529 0,23405203 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,23038044 0,24140092 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,23038044 0,24129099 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,23038044 0,24118117 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,23038044 0,24107144 ! camera-type eye development GO:0043010 88 57 0,000 0,23038044 0,24096181 ! secondary metabolic process GO:0019748 84 57 0,000 0,23038044 0,24085228 ! developmental maturation GO:0021700 75 57 0,000 0,23038044 0,24074285 ! gonad development GO:0008406 79 57 0,000 0,23038044 0,24063352 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,23391385 0,24421328 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,23391385 0,24410247 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,23743123 0,24766069 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,23743123 0,24754843 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,24093267 0,25108524 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,24093267 0,25097153 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,24093267 0,25085791 ! fertilization GO:0009566 68 60 0,000 0,24093267 0,2507444 ! meiosis GO:0007126 96 61 0,000 0,24441822 0,25425686 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,24441822 0,25414191 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,24441822 0,25402707 ! amine catabolic process GO:0009310 90 62 0,000 0,24788798 0,25751687 ! neurotransmitter transport GO:0006836 81 62 0,000 0,24788798 0,25740061 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,24788798 0,25728445 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,24788798 0,2571684 ! meiotic cell cycle GO:0051321 97 62 0,000 0,24788798 0,25705245 ! organelle localization GO:0051640 96 62 0,000 0,24788798 0,25693661 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,25134199 0,26039936 ! regulation of lipase activity GO:0060191 109 63 0,000 0,25134199 0,26028212 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,25478034 0,26372403 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,25478034 0,26360539 ! hexose catabolic process GO:0019320 82 64 0,000 0,25478034 0,26348687 ! adaptive immune response GO:0002250 94 64 0,000 0,25478034 0,26336844 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,2582031 0,26678667 ! defense response to bacterium GO:0042742 73 65 0,000 0,2582031 0,26666687 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,26161033 0,27006453 ! antigen processing and presentation GO:0019882 96 66 0,000 0,26161033 0,26994337 ! axon guidance GO:0007411 99 66 0,000 0,26161033 0,26982231 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,26500211 0,27319805 ! acute inflammatory response GO:0002526 92 68 0,000 0,2683785 0,2765549 ! learning or memory GO:0007611 123 68 0,000 0,2683785 0,27643105 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,2683785 0,27630732 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,2683785 0,27618369 ! rhythmic process GO:0048511 105 68 0,000 0,2683785 0,27606017 ! inorganic anion transport GO:0015698 93 68 0,000 0,2683785 0,27593677 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,27173957 0,27926765 ! humoral immune response GO:0006959 86 70 0,000 0,27508539 0,2825799 ! amine transport GO:0015837 101 70 0,000 0,27508539 0,28245375 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,27508539 0,28232771 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,27841604 0,28561859 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,27841604 0,28549126 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,27841604 0,28536403 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,27841604 0,28523692 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,28173157 0,28850517 ! negative regulation of transport GO:0051051 116 73 0,000 0,28503206 0,29175511 ! regulation of blood pressure GO:0008217 107 73 0,000 0,28503206 0,29162532 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,28503206 0,29149566 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,28831757 0,29472462 ! digestion GO:0007586 97 74 0,000 0,28831757 0,29459369 ! blood coagulation GO:0007596 116 75 0,000 0,29158816 0,29780319 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,29158816 0,29767101 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,29158816 0,29753894 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,2980849 0,30403338 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,2980849 0,30389861 ! sex differentiation GO:0007548 105 77 0,000 0,2980849 0,30376397 ! protein ubiquitination GO:0016567 125 77 0,000 0,2980849 0,30362944 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,2980849 0,30349503 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,30131117 0,30664411 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,30131117 0,30650849 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,30452279 0,30963856 ! cellular respiration GO:0045333 107 79 0,000 0,30452279 0,30950173 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,30452279 0,30936503 ! regulation of lyase activity GO:0051339 133 79 0,000 0,30452279 0,30922844 ! chromatin assembly GO:0031497 102 80 0,000 0,30771984 0,31233699 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,30771984 0,31219922 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,30771984 0,31206156 ! forebrain development GO:0030900 131 80 0,000 0,30771984 0,31192403 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,31090237 0,31501121 ! hemostasis GO:0007599 125 81 0,000 0,31090237 0,3148725 ! vitamin metabolic process GO:0006766 103 81 0,000 0,31090237 0,31473391 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,31722415 0,32099232 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 0,000 0,32036353 0,32402644 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,32036353 0,32388401 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,32036353 0,32374171 ! sterol metabolic process GO:0016125 120 84 0,000 0,32036353 0,32359953 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,32348866 0,32661278 ! rRNA metabolic process GO:0016072 107 85 0,000 0,32348866 0,32646946 GO:0006364|rRNA processing, ! regulation of membrane potential GO:0042391 128 85 0,000 0,32348866 0,32632628 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,32659959 0,32932006 ! nucleosome organization GO:0034728 114 87 0,000 0,3296964 0,33229698 ! cellular defense response GO:0006968 102 87 0,000 0,3296964 0,33215143 ! female pregnancy GO:0007565 130 87 0,000 0,3296964 0,332006 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,33277914 0,33496368 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,33277914 0,33481715 GO:0016054|organic acid catabolic process, ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,33584788 0,33775694 ! hormone metabolic process GO:0042445 121 90 0,000 0,33890268 0,34068014 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,34497072 0,34662851 ! DNA recombination GO:0006310 146 92 0,000 0,34497072 0,34647714 ! sulfur metabolic process GO:0006790 118 92 0,000 0,34497072 0,34632591 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,34798408 0,34919868 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,34798408 0,34904639 ! electron transport chain GO:0022900 123 94 0,000 0,35098375 0,35190175 ! carboxylic acid transport GO:0046942 147 95 0,000 0,35396979 0,35474097 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,35694227 0,35756412 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,35990123 0,36037128 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! regulation of translation GO:0006417 151 100 0,000 0,3686977 0,36901859 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,3686977 0,36885808 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,3686977 0,3686977