pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1126-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 10 5 2,000 1,102E-06 2,534E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 1,102E-06 1,267E-03 GO:0031272|regulation of pseudopodium assembly, ! macrophage differentiation GO:0030225 10 6 2,000 2,195E-06 1,683E-03 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 4,000 3,152E-06 1,812E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 3,828E-06 1,761E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 3,828E-06 1,468E-03 ! RNA elongation GO:0006354 62 49 4,000 3,888E-06 1,278E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 6,104E-06 1,755E-03 ! regulation of vascular permeability GO:0043114 12 8 2,000 6,104E-06 1,56E-03 ! nucleus localization GO:0051647 15 9 2,000 9,124E-06 2,098E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,299E-05 2,716E-03 ! protein sumoylation GO:0016925 12 10 2,000 1,299E-05 2,489E-03 ! filopodium assembly GO:0046847 19 11 2,000 1,78E-05 3,149E-03 ! establishment or maintenance of cell polarity GO:0007163 61 34 3,000 2,159E-05 3,548E-03 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 4,000 2,278E-05 3,493E-03 ! microspike assembly GO:0030035 23 12 2,000 2,364E-05 3,399E-03 ! cGMP metabolic process GO:0046068 16 13 2,000 3,063E-05 4,144E-03 GO:0006182|cGMP biosynthetic process, ! branching morphogenesis of a tube GO:0048754 72 42 3,000 5,06E-05 6,465E-03 ! regulation of cell shape GO:0008360 78 42 3,000 5,06E-05 6,125E-03 ! transcription initiation GO:0006352 118 85 4,000 5,832E-05 6,707E-03 ! patterning of blood vessels GO:0001569 24 16 2,000 5,935E-05 6,5E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 7,181E-05 7,507E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 8,587E-05 8,587E-03 ! response to retinoic acid GO:0032526 25 18 2,000 8,587E-05 8,229E-03 ! regulation of angiogenesis GO:0045765 94 49 3,000 9,333E-05 8,587E-03 ! morphogenesis of a branching structure GO:0001763 86 49 3,000 9,333E-05 8,256E-03 ! response to vitamin A GO:0033189 26 19 2,000 1,016E-04 8,656E-03 ! negative regulation of angiogenesis GO:0016525 36 19 2,000 1,016E-04 8,347E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,093E-04 8,667E-03 ! response to vitamin GO:0033273 29 20 2,000 1,191E-04 9,133E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,191E-04 8,838E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,385E-04 9,954E-03 ! platelet activation GO:0030168 28 21 2,000 1,385E-04 9,652E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 1,577E-04 0,01066559 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 2,085E-04 0,0137045 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 2,085E-04 0,01332382 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,314E-04 0,01438592 ! protein maturation by protein folding GO:0022417 12 5 1,000 2,314E-04 0,01400734 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,314E-04 0,01364818 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 1,000 2,314E-04 0,01330697 ! neuronal ion channel clustering GO:0045161 7 5 1,000 2,314E-04 0,01298241 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,314E-04 0,01267331 ! apical protein localization GO:0045176 6 5 1,000 2,314E-04 0,01237858 ! triglyceride catabolic process GO:0019433 6 5 1,000 2,314E-04 0,01209725 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 2,314E-04 0,01182842 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 2,000 2,362E-04 0,01180773 ! regulation of caspase activity GO:0043281 97 65 3,000 2,811E-04 0,01375764 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 3,159E-04 0,01513851 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 3,328E-04 0,01562328 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,46E-04 0,01591787 ! mRNA stabilization GO:0048255 15 6 1,000 3,46E-04 0,01560576 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 3,46E-04 0,01530565 GO:0031958|corticosteroid receptor signaling pathway, ! amyloid precursor protein catabolic process GO:0042987 9 6 1,000 3,46E-04 0,01501686 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 3,46E-04 0,01473877 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 3,46E-04 0,01447079 ! glycerol ether catabolic process GO:0044269 8 6 1,000 3,46E-04 0,01421239 GO:0046464|acylglycerol catabolic process, ! male sex determination GO:0030238 9 6 1,000 3,46E-04 0,01396305 ! regulation of meiosis GO:0040020 10 6 1,000 3,46E-04 0,0137223 GO:0051445|regulation of meiotic cell cycle, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 3,46E-04 0,01348972 ! regulation of peptidase activity GO:0052547 106 72 3,000 4,163E-04 0,01595851 ! response to hypoxia GO:0001666 132 72 3,000 4,163E-04 0,0156969 ! regulation of blood pressure GO:0008217 107 73 3,000 4,388E-04 0,0162789 ! tube morphogenesis GO:0035239 118 73 3,000 4,388E-04 0,0160205 ! response to oxygen levels GO:0070482 137 74 3,000 4,622E-04 0,01661001 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 4,829E-04 0,01708814 ! neutral lipid catabolic process GO:0046461 9 7 1,000 4,829E-04 0,01682923 ! T-helper 1 type immune response GO:0042088 11 7 1,000 4,829E-04 0,01657804 ! glycerolipid catabolic process GO:0046503 9 7 1,000 4,829E-04 0,01633425 ! asymmetric protein localization GO:0008105 8 7 1,000 4,829E-04 0,01609752 ! protein heterooligomerization GO:0051291 10 7 1,000 4,829E-04 0,01586756 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 1,000 4,829E-04 0,01564407 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 1,000 4,829E-04 0,01542679 ! diuresis GO:0030146 12 7 1,000 4,829E-04 0,01521547 GO:0030147|natriuresis, ! regulation of cell morphogenesis GO:0022604 140 76 3,000 5,116E-04 0,01590016 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 5,447E-04 0,01670412 ! carbohydrate homeostasis GO:0033500 39 33 2,000 5,447E-04 0,01648433 GO:0042593|glucose homeostasis, ! cellular response to insulin stimulus GO:0032869 52 34 2,000 5,953E-04 0,01778236 ! induction of positive chemotaxis GO:0050930 14 8 1,000 6,419E-04 0,01892682 ! amyloid precursor protein metabolic process GO:0042982 12 8 1,000 6,419E-04 0,01868724 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 6,419E-04 0,01845365 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 6,419E-04 0,01822583 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 6,419E-04 0,01800356 ! regulation of embryonic development GO:0045995 16 8 1,000 6,419E-04 0,01778665 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 6,419E-04 0,01757491 ! cyclic nucleotide metabolic process GO:0009187 58 35 2,000 6,489E-04 0,0175573 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 7,81E-04 0,02088828 ! regulation of developmental growth GO:0048638 13 9 1,000 8,226E-04 0,02174821 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 8,226E-04 0,02150107 ! regulation of glycolysis GO:0006110 15 9 1,000 8,226E-04 0,02125949 ! lung alveolus development GO:0048286 17 9 1,000 8,226E-04 0,02102327 ! motor axon guidance GO:0008045 14 9 1,000 8,226E-04 0,02079225 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 8,226E-04 0,02056624 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 8,226E-04 0,0203451 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 1,000 8,226E-04 0,02012866 ! renal water homeostasis GO:0003091 14 9 1,000 8,226E-04 0,01991678 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 8,226E-04 0,01970932 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 8,226E-04 0,01950613 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 1,000 8,226E-04 0,01930709 ! sequestering of metal ion GO:0051238 11 9 1,000 8,226E-04 0,01911206 ! localization within membrane GO:0051668 15 9 1,000 8,226E-04 0,01892094 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 1,025E-03 0,02334307 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,025E-03 0,02311421 ! blood vessel remodeling GO:0001974 21 10 1,000 1,025E-03 0,0228898 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,025E-03 0,02266971 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,025E-03 0,02245381 ! regulation of bone resorption GO:0045124 24 10 1,000 1,025E-03 0,02224198 ! DNA methylation GO:0006306 15 10 1,000 1,025E-03 0,02203411 GO:0006305|DNA alkylation, ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,025E-03 0,02183009 ! multicellular organismal water homeostasis GO:0050891 15 10 1,000 1,025E-03 0,02162981 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,025E-03 0,02143318 GO:0043470|regulation of carbohydrate catabolic process, ! angiogenesis GO:0001525 149 95 3,000 1,184E-03 0,02452655 ! activation of caspase activity GO:0006919 65 43 2,000 1,19E-03 0,02443079 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 1,19E-03 0,02421459 ! response to insulin stimulus GO:0032868 63 43 2,000 1,19E-03 0,02400218 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 1,249E-03 0,02497805 ! virus-host interaction GO:0019048 17 11 1,000 1,249E-03 0,02476272 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,249E-03 0,02455108 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 1,249E-03 0,02434302 GO:0050927|positive regulation of positive chemotaxis, ! T cell proliferation GO:0042098 20 11 1,000 1,249E-03 0,02413845 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 1,249E-03 0,0239373 ! membrane protein proteolysis GO:0033619 18 11 1,000 1,249E-03 0,02373947 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of phagocytosis GO:0050764 14 11 1,000 1,249E-03 0,02354489 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,249E-03 0,02335346 ! germ cell migration GO:0008354 18 11 1,000 1,249E-03 0,02316513 ! regulation of cell projection organization GO:0031344 83 44 2,000 1,272E-03 0,02340968 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 1,279E-03 0,02334365 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,358E-03 0,02460065 ! vascular process in circulatory system GO:0003018 69 45 2,000 1,358E-03 0,02440845 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 1,358E-03 0,02421924 ! regulation of body fluid levels GO:0050878 154 100 3,000 1,431E-03 0,02532488 ! response to UV GO:0009411 75 46 2,000 1,448E-03 0,02542436 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,494E-03 0,02603102 ! glycoprotein catabolic process GO:0006516 19 12 1,000 1,494E-03 0,0258353 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,494E-03 0,0256425 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,494E-03 0,02545255 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,494E-03 0,0252654 ! regulation of mRNA stability GO:0043488 27 12 1,000 1,494E-03 0,02508098 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 1,494E-03 0,02489924 ! positive regulation of caspase activity GO:0043280 72 48 2,000 1,638E-03 0,02711096 GO:0010952|positive regulation of peptidase activity, ! regulation of DNA replication GO:0006275 75 48 2,000 1,638E-03 0,02691731 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 2,000 1,739E-03 0,02837014 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,76E-03 0,02850726 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,76E-03 0,0283079 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,76E-03 0,02811132 ! cellular pigmentation GO:0033059 24 13 1,000 1,76E-03 0,02791745 ! regulation of RNA stability GO:0043487 28 13 1,000 1,76E-03 0,02772623 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,952E-03 0,03054434 ! activation of phospholipase C activity GO:0007202 87 51 2,000 1,952E-03 0,03033796 GO:0010863|positive regulation of phospholipase C activity, ! neuron maturation GO:0042551 21 14 1,000 2,047E-03 0,03159604 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,047E-03 0,0313854 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 2,047E-03 0,03117755 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 2,047E-03 0,03097244 GO:0060675|ureteric bud morphogenesis, ! DNA unwinding during replication GO:0006268 21 14 1,000 2,047E-03 0,03077 ! water homeostasis GO:0030104 24 14 1,000 2,047E-03 0,0305702 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 2,047E-03 0,03037297 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 2,047E-03 0,03017827 ! aging GO:0007568 79 52 2,000 2,064E-03 0,030244 ! establishment of organelle localization GO:0051656 85 52 2,000 2,064E-03 0,03005258 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 2,064E-03 0,02986357 ! cell projection assembly GO:0030031 76 53 2,000 2,181E-03 0,03134792 ! regulation of protein complex assembly GO:0043254 81 54 2,000 2,301E-03 0,03287082 ! regulation of phospholipase activity GO:0010517 90 54 2,000 2,301E-03 0,03266792 ! positive regulation of lipase activity GO:0060193 90 54 2,000 2,301E-03 0,0324675 ! lipid phosphorylation GO:0046834 23 15 1,000 2,354E-03 0,03301809 ! myoblast differentiation GO:0045445 27 15 1,000 2,354E-03 0,03281798 ! regulation of vasodilation GO:0042312 24 15 1,000 2,354E-03 0,03262028 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 2,354E-03 0,03242495 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 2,354E-03 0,03223195 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 2,554E-03 0,03475287 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,682E-03 0,03628844 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,682E-03 0,03607623 ! protein export from nucleus GO:0006611 24 16 1,000 2,682E-03 0,03586648 ! DNA replication initiation GO:0006270 25 16 1,000 2,682E-03 0,03565916 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,682E-03 0,03545422 ! negative regulation of translation GO:0017148 22 16 1,000 2,682E-03 0,03525163 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 2,686E-03 0,03510192 ! viral reproductive process GO:0022415 87 58 2,000 2,823E-03 0,0366793 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 2,823E-03 0,03647324 ! activation of MAPK activity GO:0000187 84 59 2,000 2,964E-03 0,03807949 ! lung development GO:0030324 94 59 2,000 2,964E-03 0,03786793 ! nucleoside monophosphate metabolic process GO:0009123 95 59 2,000 2,964E-03 0,03765872 ! myeloid cell differentiation GO:0030099 85 59 2,000 2,964E-03 0,0374518 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 3,03E-03 0,03808498 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 3,03E-03 0,037878 ! DNA duplex unwinding GO:0032508 25 17 1,000 3,03E-03 0,03767325 GO:0032392|DNA geometric change, ! body fluid secretion GO:0007589 27 17 1,000 3,03E-03 0,03747071 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 3,03E-03 0,03727033 ! regulation of homeostatic process GO:0032844 105 60 2,000 3,109E-03 0,03803196 ! cell-matrix adhesion GO:0007160 114 61 2,000 3,258E-03 0,03964907 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 3,398E-03 0,04113715 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 3,398E-03 0,04092177 ! pancreas development GO:0031016 26 18 1,000 3,398E-03 0,04070863 ! somitogenesis GO:0001756 24 18 1,000 3,398E-03 0,04049771 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 3,398E-03 0,04028896 ! respiratory tube development GO:0030323 99 62 2,000 3,412E-03 0,04024265 ! organelle localization GO:0051640 96 62 2,000 3,412E-03 0,04003733 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 3,57E-03 0,04168034 ! viral reproduction GO:0016032 92 63 2,000 3,57E-03 0,04146984 ! regulation of lipase activity GO:0060191 109 63 2,000 3,57E-03 0,04126145 ! respiratory system development GO:0060541 100 64 2,000 3,733E-03 0,04292447 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 3,786E-03 0,04332388 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 3,786E-03 0,0431094 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 3,786E-03 0,04289704 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 3,786E-03 0,04268676 ! sex determination GO:0007530 29 19 1,000 3,786E-03 0,04247853 ! plasma membrane fusion GO:0045026 23 19 1,000 3,786E-03 0,04227232 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 3,786E-03 0,04206811 ! renal system process GO:0003014 35 19 1,000 3,786E-03 0,04186586 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 3,786E-03 0,04166554 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 3,786E-03 0,04146714 ! protein stabilization GO:0050821 26 19 1,000 3,786E-03 0,04127061 ! protein oligomerization GO:0051259 100 65 2,000 3,9E-03 0,04230663 ! cell-substrate adhesion GO:0031589 121 66 2,000 4,071E-03 0,04395983 ! DNA modification GO:0006304 28 20 1,000 4,194E-03 0,04507113 ! positive regulation of locomotion GO:0040017 35 20 1,000 4,194E-03 0,0448615 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! protein amino acid acylation GO:0043543 37 21 1,000 4,62E-03 0,04919898 ! regulation of chemotaxis GO:0050920 36 21 1,000 4,62E-03 0,04897226 ! cell aging GO:0007569 32 21 1,000 4,62E-03 0,04874761 ! regulation of insulin secretion GO:0050796 26 21 1,000 4,62E-03 0,04852502 ! vasculogenesis GO:0001570 33 22 1,000 5,066E-03 0,05296784 ! ureteric bud development GO:0001657 32 22 1,000 5,066E-03 0,05272817 ! regulation of behavior GO:0050795 38 22 1,000 5,066E-03 0,05249065 ! protein tetramerization GO:0051262 39 22 1,000 5,066E-03 0,05225527 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 5,532E-03 0,05679739 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 5,532E-03 0,05654496 ! interaction with host GO:0051701 37 23 1,000 5,532E-03 0,05629476 ! lymphocyte proliferation GO:0046651 36 23 1,000 5,532E-03 0,05604676 ! cellular response to oxidative stress GO:0034599 33 23 1,000 5,532E-03 0,05580094 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 5,609E-03 0,05633326 ! blood coagulation GO:0007596 116 75 2,000 5,822E-03 0,05822267 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 2,000 5,822E-03 0,05797062 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 6,015E-03 0,05963626 ! initiation of viral infection GO:0019059 42 24 1,000 6,015E-03 0,05938031 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 6,015E-03 0,05912654 ! fat cell differentiation GO:0045444 37 24 1,000 6,015E-03 0,05887494 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 6,015E-03 0,05862547 ! regulation of peptide secretion GO:0002791 34 25 1,000 6,518E-03 0,06325518 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 6,518E-03 0,0629894 ! leukocyte proliferation GO:0070661 39 25 1,000 6,518E-03 0,06272585 GO:0032943|mononuclear cell proliferation, ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 7,039E-03 0,06745741 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 7,039E-03 0,06717751 ! hemostasis GO:0007599 125 81 2,000 7,205E-03 0,0684766 ! regulation of cell cycle process GO:0010564 122 81 2,000 7,205E-03 0,06819481 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 7,578E-03 0,07143479 ! positive regulation of endocytosis GO:0045807 33 28 1,000 8,136E-03 0,07637541 ! triglyceride metabolic process GO:0006641 34 28 1,000 8,136E-03 0,07606495 ! positive regulation of catabolic process GO:0009896 40 28 1,000 8,136E-03 0,07575699 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 8,226E-03 0,07628762 ! cell cycle arrest GO:0007050 150 86 2,000 8,494E-03 0,07845507 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 8,711E-03 0,08014008 ! skeletal muscle tissue development GO:0007519 123 87 2,000 8,767E-03 0,08033064 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 8,767E-03 0,08001187 ! leukocyte differentiation GO:0002521 143 90 2,000 9,616E-03 0,08741758 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 9,616E-03 0,08707341 ! segmentation GO:0035282 41 31 1,000 9,914E-03 0,08942312 ! metanephros development GO:0001656 58 31 1,000 9,914E-03 0,08907381 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 0,0105118 0,09407447 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,01054213 0,09398021 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 1,000 0,01054213 0,09361735 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01054213 0,09325729 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01054213 0,09289998 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 0,01118712 0,09820757 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01118712 0,09783416 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,01118712 0,09746357 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,01145458 0,09941711 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,01145458 0,09904336 ! protein maturation GO:0051604 129 96 2,000 0,01145458 0,09867241 ! response to light stimulus GO:0009416 153 96 2,000 0,01145458 0,09830423 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01184911 0,1013121 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,01184911 0,10093687 ! neuron migration GO:0001764 46 34 1,000 0,01184911 0,10056441 ! Notch signaling pathway GO:0007219 56 35 1,000 0,01252791 0,10593457 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,01252791 0,10554653 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,01252791 0,10516132 ! protein homooligomerization GO:0051260 52 35 1,000 0,01252791 0,10477892 ! regulation of translation GO:0006417 151 100 2,000 0,0127853 0,1065442 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01322336 0,10979684 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01322336 0,10940188 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,01322336 0,10900976 ! organic ether metabolic process GO:0018904 46 36 1,000 0,01322336 0,10862044 ! tissue remodeling GO:0048771 62 36 1,000 0,01322336 0,10823389 ! amino acid activation GO:0043038 52 37 1,000 0,01393527 0,11365645 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! mesenchymal cell development GO:0014031 64 38 1,000 0,01466347 0,1191731 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 1,000 0,01466347 0,11875348 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,0154078 0,12434365 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,0154078 0,12390889 ! response to calcium ion GO:0051592 58 40 1,000 0,01616808 0,12956998 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,01616808 0,12912009 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,01616808 0,1286733 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,01616808 0,1282296 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01616808 0,12778895 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01694414 0,13346415 ! biopolymer methylation GO:0043414 62 41 1,000 0,01694414 0,13300864 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,01773582 0,13874964 ! excretion GO:0007588 63 42 1,000 0,01773582 0,1382793 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01773582 0,13781214 ! positive regulation of binding GO:0051099 59 43 1,000 0,01854295 0,14359863 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,01854295 0,14311675 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,01854295 0,1426381 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,01854295 0,14216264 ! methylation GO:0032259 64 43 1,000 0,01854295 0,14169034 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,01936537 0,14748458 ! regulation of translational initiation GO:0006446 64 45 1,000 0,0202029 0,15335535 ! cell maturation GO:0048469 60 45 1,000 0,0202029 0,15285089 ! histone modification GO:0016570 68 46 1,000 0,02105539 0,15877837 ! viral infectious cycle GO:0019058 71 47 1,000 0,02192268 0,16477832 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02192268 0,16424158 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02192268 0,16370833 ! heart morphogenesis GO:0003007 65 48 1,000 0,0228046 0,169743 ! regulation of endocytosis GO:0030100 63 48 1,000 0,0228046 0,16919545 ! nuclear export GO:0051168 69 48 1,000 0,0228046 0,16865141 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,023701 0,17471893 ! germ cell development GO:0007281 68 49 1,000 0,023701 0,17416073 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,023701 0,17360607 ! maintenance of location GO:0051235 84 49 1,000 0,023701 0,17305494 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02407819 0,17525265 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02407819 0,1746998 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02407819 0,17415043 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02407819 0,1736045 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02407819 0,17306199 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02407819 0,17252286 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02407819 0,17198707 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02407819 0,1714546 ! sleep GO:0030431 11 5 0,000 0,02407819 0,17092542 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02407819 0,1703995 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02407819 0,1698768 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02407819 0,1693573 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02407819 0,16884097 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02407819 0,16832777 ! tongue development GO:0043586 6 5 0,000 0,02407819 0,16781769 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02407819 0,16731068 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02407819 0,16680674 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02407819 0,16630582 ! cobalt ion transport GO:0006824 9 5 0,000 0,02407819 0,16580789 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02407819 0,16531294 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02407819 0,16482094 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02407819 0,16433186 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02407819 0,16384567 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02407819 0,16336235 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02407819 0,16288187 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02407819 0,16240421 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02407819 0,16192935 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02407819 0,16145725 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02407819 0,1609879 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02407819 0,16052127 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02407819 0,16005733 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02407819 0,15959607 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02407819 0,15913746 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02407819 0,15868148 ! malate metabolic process GO:0006108 7 5 0,000 0,02407819 0,1582281 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02407819 0,15777731 ! behavioral response to pain GO:0048266 7 5 0,000 0,02407819 0,15732908 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02407819 0,15688339 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02407819 0,15644022 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02407819 0,15599954 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02407819 0,15556134 ! mating behavior GO:0007617 6 5 0,000 0,02407819 0,15512559 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02407819 0,15469228 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02407819 0,15426138 ! rhythmic behavior GO:0007622 12 5 0,000 0,02407819 0,15383288 ! copulation GO:0007620 7 5 0,000 0,02407819 0,15340675 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02407819 0,15298297 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02407819 0,15256153 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02407819 0,15214241 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02407819 0,15172558 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02407819 0,15131103 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02407819 0,15089874 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02407819 0,15048869 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02407819 0,15008086 ! response to protozoan GO:0001562 9 5 0,000 0,02407819 0,14967523 ! lymph vessel development GO:0001945 7 5 0,000 0,02407819 0,1492718 ! endochondral ossification GO:0001958 12 5 0,000 0,02407819 0,14887053 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02407819 0,14847141 ! parathyroid gland development GO:0060017 8 5 0,000 0,02407819 0,14807443 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02407819 0,14767956 ! anagen GO:0042640 6 5 0,000 0,02407819 0,1472868 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02407819 0,14689612 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02407819 0,1465075 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02407819 0,14612094 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02407819 0,14573641 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02407819 0,1453539 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02407819 0,14497339 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02407819 0,14459487 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02407819 0,14421832 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02407819 0,14384373 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02407819 0,14347108 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02407819 0,14310035 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02407819 0,14273154 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02407819 0,14236462 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02407819 0,14199958 ! ovulation GO:0030728 6 5 0,000 0,02407819 0,14163641 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02407819 0,14127509 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02407819 0,14091561 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02407819 0,14055796 ! response to pH GO:0009268 9 5 0,000 0,02407819 0,14020212 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02407819 0,13984807 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02407819 0,13949581 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02407819 0,13914532 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02407819 0,13879658 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02407819 0,13844959 ! polyol catabolic process GO:0046174 7 5 0,000 0,02407819 0,13810433 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02407819 0,13776079 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02407819 0,13741895 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02407819 0,1370788 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02407819 0,13674034 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02407819 0,13640354 ! urea metabolic process GO:0019627 6 5 0,000 0,02407819 0,13606839 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02407819 0,13573489 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02407819 0,13540302 ! neutrophil activation GO:0042119 5 5 0,000 0,02407819 0,13507277 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02407819 0,13474413 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02407819 0,13441708 ! response to food GO:0032094 5 5 0,000 0,02407819 0,13409161 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02407819 0,13376772 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02407819 0,13344539 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02407819 0,13312461 ! forebrain neuron development GO:0021884 7 5 0,000 0,02407819 0,13280536 ! melanosome organization GO:0032438 7 5 0,000 0,02407819 0,13248765 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02407819 0,13217145 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02407819 0,13185675 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02407819 0,13154355 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02407819 0,13123184 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02407819 0,1309216 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02407819 0,13061282 ! nucleoside transport GO:0015858 6 5 0,000 0,02407819 0,1303055 ! nucleoside salvage GO:0043174 7 5 0,000 0,02407819 0,12999962 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02407819 0,12969517 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02407819 0,12939214 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02407819 0,12909053 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02407819 0,12879032 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02407819 0,1284915 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02407819 0,12819407 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02407819 0,12789801 ! depyrimidination GO:0045008 8 5 0,000 0,02407819 0,12760331 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02407819 0,12730997 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02407819 0,12701797 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02407819 0,12672731 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02407819 0,12643798 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02407819 0,12614997 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02407819 0,12586326 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02407819 0,12557786 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02407819 0,12529375 ! monocyte differentiation GO:0030224 8 5 0,000 0,02407819 0,12501092 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02407819 0,12472936 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02407819 0,12444907 ! centrosome duplication GO:0051298 5 5 0,000 0,02407819 0,12417004 ! response to UV-C GO:0010225 6 5 0,000 0,02407819 0,12389225 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02407819 0,12361571 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02407819 0,12334039 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02407819 0,1230663 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02407819 0,12279343 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02407819 0,12252176 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02407819 0,12225129 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02407819 0,12198202 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02407819 0,12171393 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02407819 0,12144701 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02407819 0,12118126 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02407819 0,12091667 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02407819 0,12065324 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02407819 0,12039095 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02407819 0,1201298 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02407819 0,11986978 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02407819 0,11961088 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02407819 0,1193531 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02407819 0,11909642 ! neural tube patterning GO:0021532 6 5 0,000 0,02407819 0,11884085 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02407819 0,11858637 ! histone demethylation GO:0016577 9 5 0,000 0,02407819 0,11833298 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02407819 0,11808067 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02407819 0,11782944 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02407819 0,11757927 ! enteric nervous system development GO:0048484 8 5 0,000 0,02407819 0,11733016 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02407819 0,11708211 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02407819 0,1168351 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02407819 0,11658913 ! transcription termination GO:0006353 8 5 0,000 0,02407819 0,11634419 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02407819 0,11610029 ! plasminogen activation GO:0031639 5 5 0,000 0,02407819 0,1158574 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02407819 0,11561553 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02407819 0,11537466 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02407819 0,1151348 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02407819 0,11489593 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02407819 0,11465805 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02407819 0,11442115 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02407819 0,11418523 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02407819 0,11395028 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02407819 0,1137163 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02407819 0,11348327 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02407819 0,1132512 ! glial cell migration GO:0008347 10 5 0,000 0,02407819 0,11302007 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02407819 0,11278989 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02407819 0,11256064 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02407819 0,11233233 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02407819 0,11210493 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02407819 0,11187846 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02407819 0,1116529 ! neural plate development GO:0001840 6 5 0,000 0,02407819 0,11142824 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02407819 0,11120449 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02407819 0,11098164 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02407819 0,11075967 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02407819 0,1105386 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02407819 0,1103184 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02407819 0,11009908 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02407819 0,10988063 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02407819 0,10966304 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02407819 0,10944632 ! spindle assembly GO:0051225 5 5 0,000 0,02407819 0,10923045 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02407819 0,10901543 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02407819 0,10880125 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02407819 0,10858791 ! organ regeneration GO:0031100 7 5 0,000 0,02407819 0,10837541 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02407819 0,10816374 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02407819 0,1079529 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02407819 0,10774287 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02407819 0,10753366 GO:0055081|anion homeostasis, ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,02461172 0,10970341 ! membrane fusion GO:0006944 80 50 1,000 0,02461172 0,10949122 ! lipid modification GO:0030258 73 50 1,000 0,02461172 0,10927984 ! positive regulation of growth GO:0045927 67 50 1,000 0,02461172 0,10906928 ! positive regulation of secretion GO:0051047 71 51 1,000 0,0255366 0,11295035 ! muscle fiber development GO:0048747 74 51 1,000 0,0255366 0,11273355 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,0255366 0,11251759 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,02742822 0,12062124 ! kidney development GO:0001822 90 53 1,000 0,02742822 0,12039104 ! regulation of mitosis GO:0007088 84 54 1,000 0,02839465 0,12439563 GO:0051783|regulation of nuclear division, ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,02839465 0,12415913 ! tRNA transcription GO:0009304 11 6 0,000 0,02882462 0,12580005 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02882462 0,12556179 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02882462 0,12532443 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02882462 0,12508797 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02882462 0,1248524 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02882462 0,12461772 ! regulation of helicase activity GO:0051095 11 6 0,000 0,02882462 0,12438391 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02882462 0,12415098 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02882462 0,12391893 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02882462 0,12368773 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02882462 0,1234574 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02882462 0,12322793 ! prostate gland development GO:0030850 9 6 0,000 0,02882462 0,1229993 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02882462 0,12277153 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02882462 0,12254459 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02882462 0,1223185 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02882462 0,12209323 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02882462 0,1218688 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02882462 0,12164518 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02882462 0,12142239 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02882462 0,12120041 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02882462 0,12097924 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02882462 0,12075888 ! neuron adhesion GO:0007158 9 6 0,000 0,02882462 0,12053932 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02882462 0,12032055 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02882462 0,12010258 ! signal peptide processing GO:0006465 8 6 0,000 0,02882462 0,1198854 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02882462 0,119669 ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02882462 0,11945338 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02882462 0,11923853 ! opsonization GO:0008228 8 6 0,000 0,02882462 0,11902446 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02882462 0,11881116 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02882462 0,11859861 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02882462 0,11838683 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02882462 0,1181758 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02882462 0,11796553 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02882462 0,11775599 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02882462 0,11754721 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02882462 0,11733916 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02882462 0,11713185 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02882462 0,11692526 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02882462 0,11671941 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02882462 0,11651428 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02882462 0,11630987 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02882462 0,11610617 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02882462 0,11590319 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02882462 0,11570092 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02882462 0,11549935 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02882462 0,11529848 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02882462 0,11509831 ! thymic T cell selection GO:0045061 12 6 0,000 0,02882462 0,11489883 ! protein lipoylation GO:0009249 10 6 0,000 0,02882462 0,11470004 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02882462 0,11450194 ! pigment granule organization GO:0048753 11 6 0,000 0,02882462 0,11430453 ! drug transport GO:0015893 6 6 0,000 0,02882462 0,11410779 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02882462 0,11391173 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02882462 0,11371634 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02882462 0,11352162 ! histidine metabolic process GO:0006547 6 6 0,000 0,02882462 0,11332756 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02882462 0,11313417 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02882462 0,11294144 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02882462 0,11274936 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02882462 0,11255794 ! adenohypophysis development GO:0021984 10 6 0,000 0,02882462 0,11236716 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02882462 0,11217703 ! hyperosmotic response GO:0006972 8 6 0,000 0,02882462 0,11198754 ! microtubule nucleation GO:0007020 10 6 0,000 0,02882462 0,11179869 ! ER overload response GO:0006983 7 6 0,000 0,02882462 0,11161048 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02882462 0,1114229 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02882462 0,11123595 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02882462 0,11104962 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02882462 0,11086392 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02882462 0,11067884 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02882462 0,11049438 ! response to dietary excess GO:0002021 7 6 0,000 0,02882462 0,11031052 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02882462 0,11012728 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02882462 0,10994465 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02882462 0,10976262 ! purine salvage GO:0043101 8 6 0,000 0,02882462 0,1095812 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02882462 0,10940037 ! neuron apoptosis GO:0051402 8 6 0,000 0,02882462 0,10922014 ! organic alcohol transport GO:0015850 9 6 0,000 0,02882462 0,1090405 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02882462 0,10886145 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02882462 0,10868299 ! carnitine transport GO:0015879 8 6 0,000 0,02882462 0,10850511 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02882462 0,10832782 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02882462 0,1081511 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02882462 0,10797496 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02882462 0,10779939 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02882462 0,10762439 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02882462 0,10744996 ! parturition GO:0007567 12 6 0,000 0,02882462 0,10727609 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02882462 0,10710279 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02882462 0,10693004 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02882462 0,10675785 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02882462 0,10658621 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02882462 0,10641513 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02882462 0,10624459 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02882462 0,1060746 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02882462 0,10590515 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02882462 0,10573624 ! astrocyte development GO:0014002 14 6 0,000 0,02882462 0,10556787 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02882462 0,10540004 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02882462 0,10523274 ! interaction with symbiont GO:0051702 8 6 0,000 0,02882462 0,10506597 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02882462 0,10489972 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02882462 0,104734 ! eating behavior GO:0042755 6 6 0,000 0,02882462 0,10456881 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02882462 0,10440413 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02882462 0,10423998 ! response to copper ion GO:0046688 9 6 0,000 0,02882462 0,10407633 ! DNA topological change GO:0006265 8 6 0,000 0,02882462 0,10391321 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02882462 0,10375059 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02882462 0,10358848 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02882462 0,10342687 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02882462 0,10326577 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02882462 0,10310517 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02882462 0,10294507 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02882462 0,10278547 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02882462 0,10262635 ! gas homeostasis GO:0033483 11 6 0,000 0,02882462 0,10246774 ! hair follicle maturation GO:0048820 7 6 0,000 0,02882462 0,10230961 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02882462 0,10215196 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02882462 0,10199481 ! Schwann cell development GO:0014044 14 6 0,000 0,02882462 0,10183813 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02882462 0,10168194 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02882462 0,10152623 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02882462 0,10137099 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02882462 0,10121622 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02882462 0,10106193 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02882462 0,10090811 ! histone ubiquitination GO:0016574 7 6 0,000 0,02882462 0,10075475 ! G2 phase GO:0051319 13 6 0,000 0,02882462 0,10060186 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02882462 0,10044943 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02882462 0,10029747 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02882462 0,10014596 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02882462 0,09999491 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02882462 0,09984431 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02882462 0,09969417 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02882462 0,09954448 ! receptor internalization GO:0031623 9 6 0,000 0,02882462 0,09939524 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02882462 0,09924644 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02882462 0,09909809 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02882462 0,09895019 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02882462 0,09880272 ! protein deubiquitination GO:0016579 8 6 0,000 0,02882462 0,09865569 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02882462 0,0985091 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,02882462 0,09836295 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02882462 0,09821722 ! axonal fasciculation GO:0007413 9 6 0,000 0,02882462 0,09807193 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02882462 0,09792707 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02882462 0,09778263 ! midbrain development GO:0030901 6 6 0,000 0,02882462 0,09763862 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02882462 0,09749504 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02882462 0,09735187 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02882462 0,09720913 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02882462 0,0970668 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02882462 0,09692489 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02882462 0,09678339 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02882462 0,09664231 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02882462 0,09650164 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02882462 0,09636137 ! adult feeding behavior GO:0008343 6 6 0,000 0,02882462 0,09622152 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02882462 0,09608207 ! blastocyst growth GO:0001832 15 6 0,000 0,02882462 0,09594302 ! pigment granule transport GO:0051904 12 6 0,000 0,02882462 0,09580437 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02882462 0,09566613 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02882462 0,09552828 ! catecholamine transport GO:0051937 7 6 0,000 0,02882462 0,09539083 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02882462 0,09525377 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02882462 0,09511711 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02882462 0,09498084 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02882462 0,09484496 ! protein prenylation GO:0018342 10 6 0,000 0,02882462 0,09470946 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02882462 0,09457436 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02882462 0,09443964 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02882462 0,0943053 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02882462 0,09417134 ! mesoderm development GO:0007498 76 55 1,000 0,02937463 0,09583213 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,030368 0,09893259 ! developmental maturation GO:0021700 75 57 1,000 0,03137462 0,10206737 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,03239433 0,10523582 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03354824 0,10883066 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03354824 0,10867738 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03354824 0,10852453 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03354824 0,10837211 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03354824 0,10822011 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03354824 0,10806855 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03354824 0,1079174 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03354824 0,10776668 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03354824 0,10761638 ! reproductive behavior GO:0019098 12 7 0,000 0,03354824 0,10746649 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03354824 0,10731703 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03354824 0,10716797 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03354824 0,10701934 ! oligopeptide transport GO:0006857 11 7 0,000 0,03354824 0,10687111 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03354824 0,10672329 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03354824 0,10657589 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03354824 0,10642888 ! RNA methylation GO:0001510 11 7 0,000 0,03354824 0,10628229 ! pericardium development GO:0060039 8 7 0,000 0,03354824 0,1061361 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03354824 0,1059903 ! fibril organization GO:0043206 13 7 0,000 0,03354824 0,10584491 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03354824 0,10569992 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03354824 0,10555532 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,03354824 0,10541112 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03354824 0,10526731 ! lipoprotein transport GO:0042953 9 7 0,000 0,03354824 0,1051239 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03354824 0,10498087 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03354824 0,10483824 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03354824 0,10469599 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03354824 0,10455412 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03354824 0,10441264 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03354824 0,10427154 ! chemosensory behavior GO:0007635 9 7 0,000 0,03354824 0,10413082 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03354824 0,10399049 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03354824 0,10385053 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03354824 0,10371094 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03354824 0,10357173 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03354824 0,1034329 ! reflex GO:0060004 12 7 0,000 0,03354824 0,10329443 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03354824 0,10315634 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03354824 0,10301861 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03354824 0,10288125 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03354824 0,10274426 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03354824 0,10260763 ! spinal cord patterning GO:0021511 7 7 0,000 0,03354824 0,10247137 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03354824 0,10233547 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03354824 0,10219992 ! adrenal gland development GO:0030325 17 7 0,000 0,03354824 0,10206474 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03354824 0,10192991 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03354824 0,10179544 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03354824 0,10166132 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03354824 0,10152755 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03354824 0,10139414 ! endosome organization GO:0007032 10 7 0,000 0,03354824 0,10126108 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03354824 0,10112836 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03354824 0,100996 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03354824 0,10086398 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03354824 0,1007323 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03354824 0,10060097 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03354824 0,10046998 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03354824 0,10033933 ! galactose metabolic process GO:0006012 10 7 0,000 0,03354824 0,10020901 ! vesicle fusion GO:0006906 15 7 0,000 0,03354824 0,10007904 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03354824 0,09994941 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,03354824 0,0998201 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03354824 0,09969114 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,03354824 0,0995625 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03354824 0,0994342 ! retinol metabolic process GO:0042572 9 7 0,000 0,03354824 0,09930623 ! behavioral fear response GO:0001662 13 7 0,000 0,03354824 0,09917859 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03354824 0,09905127 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03354824 0,09892428 ! rRNA modification GO:0000154 12 7 0,000 0,03354824 0,09879762 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03354824 0,09867128 ! response to UV-B GO:0010224 11 7 0,000 0,03354824 0,09854526 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03354824 0,09841957 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03354824 0,09829419 ! intermediate filament organization GO:0045109 11 7 0,000 0,03354824 0,09816914 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03354824 0,0980444 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03354824 0,09791998 ! fibrinolysis GO:0042730 9 7 0,000 0,03354824 0,09779587 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03354824 0,09767208 ! B cell lineage commitment GO:0002326 17 7 0,000 0,03354824 0,0975486 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03354824 0,09742543 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03354824 0,09730257 ! response to tropane GO:0014073 13 7 0,000 0,03354824 0,09718003 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03354824 0,09705779 ! melanosome localization GO:0032400 10 7 0,000 0,03354824 0,09693586 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03354824 0,09681423 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03354824 0,09669291 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03354824 0,09657189 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03354824 0,09645118 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03354824 0,09633076 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03354824 0,09621065 ! mast cell activation GO:0045576 9 7 0,000 0,03354824 0,09609084 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03354824 0,09597132 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03354824 0,0958521 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03354824 0,09573318 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03354824 0,09561455 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,03354824 0,09549621 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03354824 0,09537817 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03354824 0,09526042 ! T cell lineage commitment GO:0002360 12 7 0,000 0,03354824 0,09514296 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03354824 0,09502579 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03354824 0,09490891 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03354824 0,09479231 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03354824 0,094676 ! response to tumor cell GO:0002347 12 7 0,000 0,03354824 0,09455998 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03354824 0,09444424 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03354824 0,09432878 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03354824 0,0942136 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03354824 0,09409871 ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03354824 0,09398409 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03354824 0,09386976 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03354824 0,0937557 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03354824 0,09364192 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03354824 0,09352841 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03354824 0,09341518 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03354824 0,09330223 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03354824 0,09318954 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03354824 0,09307713 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03354824 0,09296499 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03354824 0,09285312 ! lymph node development GO:0048535 9 7 0,000 0,03354824 0,09274152 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03354824 0,09263018 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03354824 0,09251911 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03354824 0,09240831 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03354824 0,09229778 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03354824 0,0921875 ! ATP catabolic process GO:0006200 10 7 0,000 0,03354824 0,0920775 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03354824 0,09196775 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03354824 0,09185826 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03354824 0,09174904 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03354824 0,09164007 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03354824 0,09153137 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03354824 0,09142292 ! muscle adaptation GO:0043500 12 7 0,000 0,03354824 0,09131472 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03354824 0,09120679 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03354824 0,0910991 ! retina homeostasis GO:0001895 9 7 0,000 0,03354824 0,09099168 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03354824 0,0908845 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03354824 0,09077758 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03354824 0,09067091 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03354824 0,09056448 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03354824 0,09045831 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03354824 0,09035239 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03354824 0,09024671 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,03447245 0,09262457 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03447245 0,09251649 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,03447245 0,09240866 ! urogenital system development GO:0001655 101 61 1,000 0,03553056 0,09513421 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,03660118 0,09788689 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,03768417 0,1006662 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,03768417 0,10054942 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,03768417 0,10043291 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03824915 0,10182064 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03824915 0,10170293 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,03824915 0,10158549 ! axon extension GO:0048675 11 8 0,000 0,03824915 0,10146832 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03824915 0,10135142 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03824915 0,10123479 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03824915 0,10111843 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03824915 0,10100234 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03824915 0,10088651 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03824915 0,10077094 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,03824915 0,10065565 ! phosphate transport GO:0006817 10 8 0,000 0,03824915 0,10054061 ! N-glycan processing GO:0006491 12 8 0,000 0,03824915 0,10042584 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03824915 0,10031133 ! UTP metabolic process GO:0046051 8 8 0,000 0,03824915 0,10019708 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03824915 0,10008309 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03824915 0,09996936 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03824915 0,09985588 ! succinate metabolic process GO:0006105 14 8 0,000 0,03824915 0,09974267 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03824915 0,09962971 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03824915 0,09951701 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03824915 0,09940456 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03824915 0,09929236 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03824915 0,09918042 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03824915 0,09906873 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03824915 0,09895729 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03824915 0,09884611 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03824915 0,09873517 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03824915 0,09862448 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03824915 0,09851404 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03824915 0,09840384 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03824915 0,09829389 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03824915 0,09818419 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03824915 0,09807473 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03824915 0,09796552 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03824915 0,09785654 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03824915 0,09774782 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03824915 0,09763933 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03824915 0,09753108 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03824915 0,09742307 ! melanin metabolic process GO:0006582 12 8 0,000 0,03824915 0,0973153 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03824915 0,09720777 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03824915 0,09710048 ! macrophage activation GO:0042116 12 8 0,000 0,03824915 0,09699342 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03824915 0,0968866 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03824915 0,09678002 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03824915 0,09667366 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03824915 0,09656755 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03824915 0,09646166 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03824915 0,09635601 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03824915 0,09625058 ! ruffle organization GO:0031529 11 8 0,000 0,03824915 0,09614539 ! osteoblast development GO:0002076 13 8 0,000 0,03824915 0,09604043 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03824915 0,0959357 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03824915 0,09583119 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03824915 0,09572691 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03824915 0,09562286 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03824915 0,09551904 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03824915 0,09541544 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03824915 0,09531206 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03824915 0,09520891 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03824915 0,09510598 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03824915 0,09500328 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03824915 0,09490079 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03824915 0,09479853 ! segment specification GO:0007379 10 8 0,000 0,03824915 0,09469648 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03824915 0,09459466 ! cellular extravasation GO:0045123 11 8 0,000 0,03824915 0,09449305 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03824915 0,09439167 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03824915 0,0942905 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03824915 0,09418954 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03824915 0,09408881 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03824915 0,09398828 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03824915 0,09388798 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03824915 0,09378788 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03824915 0,093688 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03824915 0,09358833 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03824915 0,09348888 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03824915 0,09338963 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03824915 0,0932906 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03824915 0,09319177 ! icosanoid secretion GO:0032309 12 8 0,000 0,03824915 0,09309316 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03824915 0,09299475 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03824915 0,09289655 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03824915 0,09279856 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03824915 0,09270077 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03824915 0,09260319 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03824915 0,09250582 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03824915 0,09240865 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03824915 0,09231168 ! sterol catabolic process GO:0016127 9 8 0,000 0,03824915 0,09221492 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03824915 0,09211836 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03824915 0,092022 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03824915 0,09192585 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03824915 0,09182989 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03824915 0,09173413 ! prophase GO:0051324 11 8 0,000 0,03824915 0,09163858 ! S phase GO:0051320 8 8 0,000 0,03824915 0,09154322 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03824915 0,09144806 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03824915 0,0913531 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03824915 0,09125833 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03824915 0,09116377 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03824915 0,09106939 ! hormone catabolic process GO:0042447 13 8 0,000 0,03824915 0,09097522 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03824915 0,09088123 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03824915 0,09078744 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03824915 0,09069385 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03824915 0,09060045 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03824915 0,09050724 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03824915 0,09041422 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03824915 0,09032139 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03824915 0,09022875 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03824915 0,09013631 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03824915 0,09004405 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03824915 0,08995198 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03824915 0,0898601 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03824915 0,0897684 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03824915 0,08967689 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,03877939 0,09082748 ! negative regulation of cell size GO:0045792 108 64 1,000 0,03877939 0,09073508 ! adaptive immune response GO:0002250 94 64 1,000 0,03877939 0,09064287 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! antigen processing and presentation GO:0019882 96 66 1,000 0,04100592 0,09574986 ! axon guidance GO:0007411 99 66 1,000 0,04100592 0,09565275 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,04100592 0,09555584 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,04213696 0,09809212 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,04213696 0,09799293 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04292746 0,09973046 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04292746 0,09962982 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04292746 0,09952939 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04292746 0,09942916 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04292746 0,09932913 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04292746 0,0992293 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04292746 0,09912967 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04292746 0,09903024 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04292746 0,09893101 ! GTP metabolic process GO:0046039 9 9 0,000 0,04292746 0,09883198 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04292746 0,09873315 ! social behavior GO:0035176 14 9 0,000 0,04292746 0,09863452 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04292746 0,09853608 ! artery development GO:0060840 19 9 0,000 0,04292746 0,09843784 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04292746 0,09833979 ! response to pain GO:0048265 16 9 0,000 0,04292746 0,09824194 ! protein complex disassembly GO:0043241 17 9 0,000 0,04292746 0,09814429 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04292746 0,09804682 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04292746 0,09794955 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04292746 0,09785248 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04292746 0,0977556 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04292746 0,0976589 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04292746 0,0975624 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04292746 0,09746609 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04292746 0,09736997 ! protein targeting to ER GO:0045047 19 9 0,000 0,04292746 0,09727404 ! T cell selection GO:0045058 18 9 0,000 0,04292746 0,0971783 ! endoderm development GO:0007492 12 9 0,000 0,04292746 0,09708274 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04292746 0,09698738 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04292746 0,0968922 ! arginine catabolic process GO:0006527 10 9 0,000 0,04292746 0,09679721 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04292746 0,0967024 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04292746 0,09660778 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04292746 0,09651334 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04292746 0,09641909 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04292746 0,09632503 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04292746 0,09623114 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04292746 0,09613744 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04292746 0,09604392 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04292746 0,09595058 ! mannose metabolic process GO:0006013 9 9 0,000 0,04292746 0,09585743 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04292746 0,09576445 ! receptor clustering GO:0043113 15 9 0,000 0,04292746 0,09567166 ! epithelial cell development GO:0002064 10 9 0,000 0,04292746 0,09557904 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04292746 0,09548661 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04292746 0,09539435 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04292746 0,09530227 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04292746 0,09521037 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04292746 0,09511864 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04292746 0,09502709 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04292746 0,09493572 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04292746 0,09484453 ! DNA ligation GO:0006266 14 9 0,000 0,04292746 0,0947535 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04292746 0,09466266 ! response to amine stimulus GO:0014075 13 9 0,000 0,04292746 0,09457198 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04292746 0,09448148 ! erythrocyte development GO:0048821 11 9 0,000 0,04292746 0,09439116 ! postreplication repair GO:0006301 11 9 0,000 0,04292746 0,094301 ! mRNA cleavage GO:0006379 13 9 0,000 0,04292746 0,09421102 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04292746 0,09412121 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04292746 0,09403157 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04292746 0,0939421 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04292746 0,09385281 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04292746 0,09376368 ! acid secretion GO:0046717 14 9 0,000 0,04292746 0,09367472 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04292746 0,09358593 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04292746 0,0934973 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04292746 0,09340885 ! purine base metabolic process GO:0006144 18 9 0,000 0,04292746 0,09332056 ! oocyte differentiation GO:0009994 12 9 0,000 0,04292746 0,09323244 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,04292746 0,09314448 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04292746 0,09305669 ! spleen development GO:0048536 15 9 0,000 0,04292746 0,09296907 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04292746 0,09288161 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04292746 0,09279432 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04292746 0,09270718 ! detection of calcium ion GO:0005513 13 9 0,000 0,04292746 0,09262022 ! blastocyst formation GO:0001825 12 9 0,000 0,04292746 0,09253341 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04292746 0,09244677 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04292746 0,09236029 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04292746 0,09227397 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04292746 0,09218782 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04292746 0,09210182 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04292746 0,09201598 ! prepulse inhibition GO:0060134 14 9 0,000 0,04292746 0,09193031 ! embryonic placenta development GO:0001892 12 9 0,000 0,04292746 0,09184479 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04292746 0,09175943 ! insulin secretion GO:0030073 17 9 0,000 0,04292746 0,09167424 ! response to nicotine GO:0035094 16 9 0,000 0,04292746 0,09158919 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04292746 0,09150431 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04292746 0,09141958 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,04327967 0,0920844 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,04327967 0,09199929 ! response to drug GO:0042493 108 69 1,000 0,0444339 0,09436562 ! response to metal ion GO:0010038 103 70 1,000 0,04559952 0,09675176 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,04559952 0,09666259 ! regulation of catabolic process GO:0009894 106 70 1,000 0,04559952 0,09657358 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,04677641 0,09897492 ! muscle cell differentiation GO:0042692 104 71 1,000 0,04677641 0,09888395 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04758328 0,10049728 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04758328 0,10040508 ! neuron fate specification GO:0048665 11 10 0,000 0,04758328 0,10031305 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04758328 0,10022119 ! thyroid gland development GO:0030878 19 10 0,000 0,04758328 0,1001295 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,04758328 0,10003797 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04758328 0,09994661 ! synapsis GO:0007129 13 10 0,000 0,04758328 0,09985542 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04758328 0,09976439 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04758328 0,09967353 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04758328 0,09958284 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04758328 0,09949231 ! sulfate transport GO:0008272 12 10 0,000 0,04758328 0,09940194 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04758328 0,09931174 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,04758328 0,0992217 ! phospholipid efflux GO:0033700 16 10 0,000 0,04758328 0,09913183 ! hippocampus development GO:0021766 19 10 0,000 0,04758328 0,09904212 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04758328 0,09895257 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04758328 0,09886318 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04758328 0,09877395 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04758328 0,09868489 ! pathogenesis GO:0009405 13 10 0,000 0,04758328 0,09859598 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04758328 0,09850724 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04758328 0,09841865 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04758328 0,09833022 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04758328 0,09824196 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04758328 0,09815385 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04758328 0,0980659 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04758328 0,0979781 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04758328 0,09789047 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04758328 0,09780299 ! response to X-ray GO:0010165 16 10 0,000 0,04758328 0,09771566 ! B cell proliferation GO:0042100 14 10 0,000 0,04758328 0,09762849 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04758328 0,09754148 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04758328 0,09745462 ! forebrain cell migration GO:0021885 17 10 0,000 0,04758328 0,09736792 ! lipid digestion GO:0044241 15 10 0,000 0,04758328 0,09728137 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04758328 0,09719497 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04758328 0,09710873 ! UV protection GO:0009650 14 10 0,000 0,04758328 0,09702264 ! entry into host cell GO:0030260 20 10 0,000 0,04758328 0,09693671 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04758328 0,09685092 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04758328 0,09676529 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04758328 0,09667981 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04758328 0,09659448 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,04758328 0,09650929 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04758328 0,09642426 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04758328 0,09633938 ! regulation of organ growth GO:0046620 11 10 0,000 0,04758328 0,09625465 ! response to dsRNA GO:0043331 18 10 0,000 0,04758328 0,09617007 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04758328 0,09608564 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04758328 0,09600135 ! embryonic axis specification GO:0000578 12 10 0,000 0,04758328 0,09591721 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04758328 0,09583322 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04758328 0,09574938 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04758328 0,09566568 ! cranial nerve development GO:0021545 12 10 0,000 0,04758328 0,09558213 ! fucose catabolic process GO:0019317 16 10 0,000 0,04758328 0,09549873 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04758328 0,09541547 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04758328 0,09533235 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04758328 0,09524938 ! zymogen activation GO:0031638 14 10 0,000 0,04758328 0,09516656 ! salivary gland development GO:0007431 22 10 0,000 0,04758328 0,09508388 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04758328 0,09500134 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04758328 0,09491894 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04758328 0,09483669 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04758328 0,09475458 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04758328 0,09467261 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04758328 0,09459079 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04758328 0,0945091 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04758328 0,09442756 ! detection of bacterium GO:0016045 10 10 0,000 0,04758328 0,09434616 ! embryonic gut development GO:0048566 11 10 0,000 0,04758328 0,09426489 ! activation of innate immune response GO:0002218 10 10 0,000 0,04758328 0,09418377 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04758328 0,09410279 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04758328 0,09402194 ! developmental induction GO:0031128 13 10 0,000 0,04758328 0,09394124 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04758328 0,09386067 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04758328 0,09378024 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04758328 0,09369995 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04758328 0,09361979 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,04796441 0,09428901 GO:0045937|positive regulation of phosphate metabolic process, ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,0491634 0,09656347 ! protein import into nucleus GO:0006606 118 74 1,000 0,05037325 0,09885536 ! response to inorganic substance GO:0010035 115 75 1,000 0,05159383 0,10116436 ! negative regulation of growth GO:0045926 123 75 1,000 0,05159383 0,10107819 ! nuclear import GO:0051170 121 75 1,000 0,05159383 0,10099217 ! rRNA transcription GO:0009303 17 11 0,000 0,05221672 0,10212453 ! respiratory burst GO:0045730 14 11 0,000 0,05221672 0,10203776 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05221672 0,10195114 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,05221672 0,10186467 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,05221672 0,10177834 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,05221672 0,10169216 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05221672 0,10160613 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,05221672 0,10152024 ! mating GO:0007618 14 11 0,000 0,05221672 0,1014345 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,05221672 0,1013489 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,05221672 0,10126345 ! bone resorption GO:0045453 16 11 0,000 0,05221672 0,10117814 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05221672 0,10109297 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,05221672 0,10100795 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,05221672 0,10092306 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,05221672 0,10083833 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05221672 0,10075373 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05221672 0,10066928 ! syncytium formation GO:0006949 15 11 0,000 0,05221672 0,10058496 ! plasma membrane organization GO:0007009 18 11 0,000 0,05221672 0,10050079 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05221672 0,10041676 ! focal adhesion formation GO:0048041 24 11 0,000 0,05221672 0,10033287 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05221672 0,10024912 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05221672 0,10016551 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,05221672 0,10008204 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05221672 0,09999871 ! adult heart development GO:0007512 11 11 0,000 0,05221672 0,09991551 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,05221672 0,09983246 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,05221672 0,09974954 ! temperature homeostasis GO:0001659 16 11 0,000 0,05221672 0,09966676 ! L-glutamate transport GO:0015813 16 11 0,000 0,05221672 0,09958412 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,05221672 0,09950161 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05221672 0,09941924 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05221672 0,09933701 ! stem cell development GO:0048864 29 11 0,000 0,05221672 0,09925491 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,05221672 0,09917295 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,05221672 0,09909113 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,05221672 0,09900944 ! vasoconstriction GO:0042310 15 11 0,000 0,05221672 0,09892788 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05221672 0,09884646 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05221672 0,09876517 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,05221672 0,09868402 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05221672 0,09860299 ! ribosome assembly GO:0042255 13 11 0,000 0,05221672 0,09852211 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05221672 0,09844135 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,05221672 0,09836073 ! chromatin silencing GO:0006342 19 11 0,000 0,05221672 0,09828023 ! nucleosome positioning GO:0016584 13 11 0,000 0,05221672 0,09819987 ! T cell homeostasis GO:0043029 20 11 0,000 0,05221672 0,09811965 ! regulation of isotype switching GO:0045191 19 11 0,000 0,05221672 0,09803955 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,05221672 0,09795958 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,05221672 0,09787974 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,05221672 0,09780004 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05221672 0,09772046 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05221672 0,09764101 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,05221672 0,0975617 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,05221672 0,09748251 ! male genitalia development GO:0030539 13 11 0,000 0,05221672 0,09740344 ! cholesterol efflux GO:0033344 19 11 0,000 0,05221672 0,09732451 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,05221672 0,09724571 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05221672 0,09716703 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05221672 0,09708848 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,05221672 0,09701005 GO:0010829|negative regulation of glucose transport, ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05221672 0,09693176 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,05221672 0,09685359 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,05221672 0,09677554 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05221672 0,09669762 ! lysogeny GO:0030069 18 11 0,000 0,05221672 0,09661983 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05221672 0,09654216 ! acrosome reaction GO:0007340 13 11 0,000 0,05221672 0,09646462 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,05221672 0,0963872 ! tRNA metabolic process GO:0006399 95 76 1,000 0,052825 0,09743183 ! regulation of protein transport GO:0051223 114 76 1,000 0,052825 0,09735376 GO:0070201|regulation of establishment of protein localization, ! one-carbon metabolic process GO:0006730 110 77 1,000 0,05406663 0,09956225 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,05406663 0,0994826 ! regulation of DNA binding GO:0051101 119 77 1,000 0,05406663 0,09940308 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,05531861 0,10162364 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,0565808 0,1038594 ! T cell activation GO:0042110 134 79 1,000 0,0565808 0,10377658 ! regulation of lyase activity GO:0051339 133 79 1,000 0,0565808 0,10369389 ! lactation GO:0007595 20 12 0,000 0,05682788 0,10406379 ! reproductive cellular process GO:0048610 14 12 0,000 0,05682788 0,103981 ! tRNA modification GO:0006400 14 12 0,000 0,05682788 0,10389834 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05682788 0,10381582 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05682788 0,10373342 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05682788 0,10365116 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05682788 0,10356903 ! non-recombinational repair GO:0000726 19 12 0,000 0,05682788 0,10348703 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05682788 0,10340515 ! peroxisomal transport GO:0043574 21 12 0,000 0,05682788 0,10332341 ! cartilage condensation GO:0001502 18 12 0,000 0,05682788 0,1032418 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05682788 0,10316031 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05682788 0,10307896 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05682788 0,10299773 ! heart looping GO:0001947 15 12 0,000 0,05682788 0,10291663 ! palate development GO:0060021 15 12 0,000 0,05682788 0,10283565 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,05682788 0,10275481 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05682788 0,10267409 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05682788 0,1025935 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05682788 0,10251303 ! arginine metabolic process GO:0006525 13 12 0,000 0,05682788 0,10243269 ! methionine metabolic process GO:0006555 13 12 0,000 0,05682788 0,10235248 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05682788 0,10227239 ! Golgi organization GO:0007030 18 12 0,000 0,05682788 0,10219243 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05682788 0,10211259 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05682788 0,10203288 ! monoamine transport GO:0015844 13 12 0,000 0,05682788 0,10195329 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05682788 0,10187382 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05682788 0,10179448 ! L-amino acid transport GO:0015807 20 12 0,000 0,05682788 0,10171526 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05682788 0,10163617 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05682788 0,1015572 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05682788 0,10147835 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05682788 0,10139962 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05682788 0,10132102 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05682788 0,10124254 ! cerebellum development GO:0021549 13 12 0,000 0,05682788 0,10116418 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05682788 0,10108594 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05682788 0,10100782 ! histone methylation GO:0016571 15 12 0,000 0,05682788 0,10092982 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05682788 0,10085194 ! gland morphogenesis GO:0022612 23 12 0,000 0,05682788 0,10077418 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05682788 0,10069654 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05682788 0,10061903 ! response to gamma radiation GO:0010332 20 12 0,000 0,05682788 0,10054163 ! regulation of epidermis development GO:0045682 17 12 0,000 0,05682788 0,10046435 ! intestinal absorption GO:0050892 19 12 0,000 0,05682788 0,10038719 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05682788 0,10031014 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05682788 0,10023322 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05682788 0,10015641 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05682788 0,10007972 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05682788 0,10000315 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05682788 0,09992669 ! response to cold GO:0009409 14 12 0,000 0,05682788 0,09985036 ! protein localization in nucleus GO:0034504 133 80 1,000 0,05785307 0,10157409 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,0591353 0,10374614 ! mRNA transport GO:0051028 121 81 1,000 0,0591353 0,10366706 ! ossification GO:0001503 134 82 1,000 0,06042736 0,10585144 GO:0060348|bone development, ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,06141686 0,10750288 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,06141686 0,10742113 ! regulation of chemokine production GO:0032642 17 13 0,000 0,06141686 0,10733951 ! water transport GO:0006833 17 13 0,000 0,06141686 0,107258 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,06141686 0,10717662 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,06141686 0,10709537 ! lipid localization GO:0010876 24 13 0,000 0,06141686 0,10701423 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,06141686 0,10693322 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,06141686 0,10685234 ! organelle fusion GO:0048284 28 13 0,000 0,06141686 0,10677157 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,06141686 0,10669093 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,06141686 0,10661041 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,06141686 0,10653001 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,06141686 0,10644973 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,06141686 0,10636957 ! response to hexose stimulus GO:0009746 19 13 0,000 0,06141686 0,10628953 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,06141686 0,10620962 ! glutamate metabolic process GO:0006536 18 13 0,000 0,06141686 0,10612982 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,06141686 0,10605014 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,06141686 0,10597058 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,06141686 0,10589115 ! NAD metabolic process GO:0019674 21 13 0,000 0,06141686 0,10581183 ! exocrine system development GO:0035272 27 13 0,000 0,06141686 0,10573263 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,06141686 0,10565354 ! bone mineralization GO:0030282 15 13 0,000 0,06141686 0,10557458 ! regulation of exocytosis GO:0017157 17 13 0,000 0,06141686 0,10549573 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,06141686 0,10541701 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,06141686 0,1053384 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,06141686 0,1052599 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,06141686 0,10518153 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,06141686 0,10510327 ! genitalia development GO:0048806 15 13 0,000 0,06141686 0,10502512 ! regulation of cellular pH GO:0030641 20 13 0,000 0,06141686 0,10494709 ! tissue regeneration GO:0042246 21 13 0,000 0,06141686 0,10486918 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,06141686 0,10479139 ! cofactor transport GO:0051181 19 13 0,000 0,06141686 0,10471371 ! NADP metabolic process GO:0006739 18 13 0,000 0,06141686 0,10463614 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,06141686 0,10455869 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,06141686 0,10448135 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06141686 0,10440413 ! gas transport GO:0015669 18 13 0,000 0,06141686 0,10432702 ! heme biosynthetic process GO:0006783 20 13 0,000 0,06141686 0,10425003 ! regulation of axon extension GO:0030516 23 13 0,000 0,06141686 0,10417315 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,06141686 0,10409638 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,06141686 0,10401973 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,06141686 0,10394319 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,06141686 0,10386676 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,06141686 0,10379044 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,06141686 0,10371424 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,06172914 0,1041651 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! rRNA metabolic process GO:0016072 107 85 1,000 0,06436135 0,1085272 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,06436135 0,10844769 ! regulation of protein localization GO:0032880 132 85 1,000 0,06436135 0,1083683 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,06436135 0,10828903 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,06569153 0,11044629 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,06569153 0,11036561 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,06598379 0,1107757 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,06598379 0,1106949 ! superoxide anion generation GO:0042554 18 14 0,000 0,06598379 0,11061422 ! regulation of S phase GO:0033261 18 14 0,000 0,06598379 0,11053366 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,06598379 0,11045321 ! myotube differentiation GO:0014902 21 14 0,000 0,06598379 0,11037288 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,06598379 0,11029267 ! inositol metabolic process GO:0006020 20 14 0,000 0,06598379 0,11021257 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,06598379 0,11013259 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,06598379 0,11005273 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,06598379 0,10997298 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,06598379 0,10989335 ! gene silencing by RNA GO:0031047 20 14 0,000 0,06598379 0,10981383 ! response to cAMP GO:0051591 19 14 0,000 0,06598379 0,10973443 ! limbic system development GO:0021761 25 14 0,000 0,06598379 0,10965514 ! startle response GO:0001964 21 14 0,000 0,06598379 0,10957596 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,06598379 0,1094969 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,06598379 0,10941796 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,06598379 0,10933913 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,06598379 0,10926041 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,06598379 0,10918181 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,06598379 0,10910331 ! glycine metabolic process GO:0006544 22 14 0,000 0,06598379 0,10902494 ! pituitary gland development GO:0021983 23 14 0,000 0,06598379 0,10894667 ! cellular response to starvation GO:0009267 21 14 0,000 0,06598379 0,10886852 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,06598379 0,10879047 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,06598379 0,10871254 ! regulation of heart rate GO:0002027 23 14 0,000 0,06598379 0,10863472 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,06598379 0,10855702 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,06598379 0,10847942 ! embryo implantation GO:0007566 27 14 0,000 0,06598379 0,10840194 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,06598379 0,10832456 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,06598379 0,1082473 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,06598379 0,10817014 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,06598379 0,1080931 ! axon cargo transport GO:0008088 27 14 0,000 0,06598379 0,10801616 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,06598379 0,10793934 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,06598379 0,10786262 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,06598379 0,10778602 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06598379 0,10770952 ! mRNA splice site selection GO:0006376 26 14 0,000 0,06598379 0,10763313 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,06598379 0,10755685 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,06598379 0,10748067 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,06598379 0,10740461 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,06598379 0,10732865 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,06598379 0,1072528 ! muscle maintenance GO:0046716 19 14 0,000 0,06598379 0,10717706 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,06598379 0,10710142 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,06598379 0,10702589 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,06598379 0,10695047 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,06598379 0,10687515 ! cell killing GO:0001906 20 14 0,000 0,06598379 0,10679994 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,06598379 0,10672483 ! cilium assembly GO:0042384 20 14 0,000 0,06598379 0,10664983 ! peptide hormone secretion GO:0030072 23 14 0,000 0,06598379 0,10657494 ! interphase GO:0051325 159 88 1,000 0,06837947 0,11036686 ! establishment of RNA localization GO:0051236 128 88 1,000 0,06837947 0,11028946 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,06837947 0,11021217 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,06973698 0,11232146 ! reproductive developmental process GO:0003006 127 89 1,000 0,06973698 0,11224286 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,06973698 0,11216437 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,07052875 0,11335857 ! positive regulation of cell size GO:0045793 20 15 0,000 0,07052875 0,11327941 ! metencephalon development GO:0022037 19 15 0,000 0,07052875 0,11320036 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,07052875 0,11312142 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,07052875 0,11304259 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,07052875 0,11296387 ! skin development GO:0043588 25 15 0,000 0,07052875 0,11288526 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,07052875 0,11280676 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,07052875 0,11272837 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,07052875 0,11265008 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,07052875 0,11257191 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,07052875 0,11249384 ! bile acid metabolic process GO:0008206 22 15 0,000 0,07052875 0,11241588 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,07052875 0,11233803 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,07052875 0,11226029 ! adult walking behavior GO:0007628 25 15 0,000 0,07052875 0,11218266 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,07052875 0,11210513 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,07052875 0,11202771 ! centrosome cycle GO:0007098 16 15 0,000 0,07052875 0,11195039 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,07052875 0,11187319 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,07052875 0,11179609 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,07052875 0,11171909 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,07052875 0,1116422 ! cerebral cortex development GO:0021987 29 15 0,000 0,07052875 0,11156542 ! response to osmotic stress GO:0006970 22 15 0,000 0,07052875 0,11148874 ! vesicle coating GO:0006901 25 15 0,000 0,07052875 0,11141217 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,07052875 0,1113357 ! DNA integration GO:0015074 22 15 0,000 0,07052875 0,11125934 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,07052875 0,11118308 ! peptide secretion GO:0002790 27 15 0,000 0,07052875 0,11110693 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,07052875 0,11103088 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,07052875 0,11095494 ! neuron recognition GO:0008038 22 15 0,000 0,07052875 0,1108791 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,07052875 0,11080336 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,07052875 0,11072773 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,07052875 0,1106522 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,07052875 0,11057677 ! biomineral formation GO:0031214 18 15 0,000 0,07052875 0,11050144 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,07052875 0,11042622 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,07052875 0,1103511 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,07052875 0,11027608 ! dopamine metabolic process GO:0042417 30 15 0,000 0,07052875 0,11020117 ! organic cation transport GO:0015695 19 15 0,000 0,07052875 0,11012635 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,07052875 0,11005164 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,07052875 0,10997703 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,07052875 0,10990252 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,07052875 0,10982811 ! peptide hormone processing GO:0016486 19 15 0,000 0,07052875 0,1097538 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,07052875 0,10967959 ! RNA localization GO:0006403 135 91 1,000 0,07247851 0,11263553 ! response to virus GO:0009615 122 91 1,000 0,07247851 0,11255947 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,0738623 0,1146311 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,0738623 0,11455381 ! cell fate commitment GO:0045165 141 92 1,000 0,0738623 0,11447661 ! protein secretion GO:0009306 27 16 0,000 0,07505185 0,11624193 ! hormone secretion GO:0046879 25 16 0,000 0,07505185 0,1161637 ! bone remodeling GO:0046849 24 16 0,000 0,07505185 0,11608558 ! endothelial cell migration GO:0043542 22 16 0,000 0,07505185 0,11600757 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,07505185 0,11592966 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07505185 0,11585185 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,07505185 0,11577415 ! glial cell development GO:0021782 24 16 0,000 0,07505185 0,11569655 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,07505185 0,11561906 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,07505185 0,11554167 ! protein polyubiquitination GO:0000209 26 16 0,000 0,07505185 0,11546439 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,07505185 0,11538721 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,07505185 0,11531013 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,07505185 0,11523315 ! fructose metabolic process GO:0006000 20 16 0,000 0,07505185 0,11515628 ! regulation of protein binding GO:0043393 27 16 0,000 0,07505185 0,11507951 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,07505185 0,11500284 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,07505185 0,11492627 ! negative regulation of immune response GO:0050777 28 16 0,000 0,07505185 0,11484981 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,07505185 0,11477344 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,07505185 0,11469718 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,07505185 0,11462102 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,07505185 0,11454496 ! diencephalon development GO:0021536 25 16 0,000 0,07505185 0,114469 ! oogenesis GO:0048477 23 16 0,000 0,07505185 0,11439315 ! neural crest cell migration GO:0001755 24 16 0,000 0,07505185 0,11431739 ! G1 phase GO:0051318 27 16 0,000 0,07505185 0,11424173 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,07505185 0,11416618 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,07505185 0,11409072 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,07505185 0,11401536 ! steroid catabolic process GO:0006706 22 16 0,000 0,07505185 0,11394011 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,07505185 0,11386495 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,07505185 0,11378989 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,07505185 0,11371493 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,07505185 0,11364007 ! sperm-egg recognition GO:0035036 16 16 0,000 0,07505185 0,1135653 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,07505185 0,11349064 ! nerve development GO:0021675 18 16 0,000 0,07505185 0,11341607 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,07505185 0,1133416 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,07505185 0,11326723 ! response to oxidative stress GO:0006979 141 94 1,000 0,07665536 0,11561136 ! regulation of binding GO:0051098 151 95 1,000 0,07806439 0,11765931 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,07948162 0,11971692 ! in utero embryonic development GO:0001701 147 96 1,000 0,07948162 0,11963857 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,07948162 0,11956032 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,0795532 0,11958978 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,0795532 0,11951167 ! negative regulation of defense response GO:0031348 19 17 0,000 0,0795532 0,11943366 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,0795532 0,11935575 ! glycerol metabolic process GO:0006071 20 17 0,000 0,0795532 0,11927794 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,0795532 0,11920024 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,0795532 0,11912263 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,0795532 0,11904513 ! signal complex assembly GO:0007172 29 17 0,000 0,0795532 0,11896773 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,0795532 0,11889043 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,0795532 0,11881322 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,0795532 0,11873612 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,0795532 0,11865912 ! memory GO:0007613 25 17 0,000 0,0795532 0,11858222 ! keratinization GO:0031424 17 17 0,000 0,0795532 0,11850542 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,0795532 0,11842872 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,0795532 0,11835211 ! retinoid metabolic process GO:0001523 22 17 0,000 0,0795532 0,11827561 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,0795532 0,1181992 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,0795532 0,1181229 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,0795532 0,11804669 ! vacuolar transport GO:0007034 24 17 0,000 0,0795532 0,11797058 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,0795532 0,11789457 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,0795532 0,11781865 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,0795532 0,11774284 ! membrane budding GO:0006900 29 17 0,000 0,0795532 0,11766712 ! heme metabolic process GO:0042168 27 17 0,000 0,0795532 0,1175915 ! actin filament bundle formation GO:0051017 26 17 0,000 0,0795532 0,11751597 ! neuromuscular junction development GO:0007528 23 17 0,000 0,0795532 0,11744054 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,0795532 0,11736521 ! stem cell differentiation GO:0048863 36 17 0,000 0,0795532 0,11728998 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,0795532 0,11721484 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,0795532 0,1171398 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,0795532 0,11706485 ! sensory perception of pain GO:0019233 23 17 0,000 0,0795532 0,11699 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,0795532 0,11691525 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,0795532 0,11684059 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,0795532 0,11676603 ! synaptogenesis GO:0007416 24 17 0,000 0,0795532 0,11669156 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,0795532 0,11661719 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,0795532 0,11654291 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,0795532 0,11646872 ! cell-cell junction organization GO:0045216 25 17 0,000 0,0795532 0,11639464 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,0795532 0,11632064 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,0795532 0,11624674 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,0795532 0,11617293 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,0795532 0,11609922 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,0795532 0,1160256 ! protein import GO:0017038 156 99 1,000 0,08378136 0,12211479 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,08378136 0,12203745 ! positive regulation of translation GO:0045727 28 18 0,000 0,0840329 0,12232638 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,0840329 0,12224901 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,0840329 0,12217173 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,0840329 0,12209455 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,0840329 0,12201747 ! cAMP metabolic process GO:0046058 33 18 0,000 0,0840329 0,12194049 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,0840329 0,12186361 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,0840329 0,12178682 ! axis specification GO:0009798 26 18 0,000 0,0840329 0,12171013 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,0840329 0,12163353 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,0840329 0,12155703 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,0840329 0,12148063 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,0840329 0,12140432 ! glutamine metabolic process GO:0006541 23 18 0,000 0,0840329 0,12132811 ! pigmentation during development GO:0048066 31 18 0,000 0,0840329 0,12125199 ! central nervous system neuron development GO:0021954 30 18 0,000 0,0840329 0,12117597 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,0840329 0,12110005 ! fucose metabolic process GO:0006004 26 18 0,000 0,0840329 0,12102422 ! response to fungus GO:0009620 19 18 0,000 0,0840329 0,12094848 ! peptide cross-linking GO:0018149 31 18 0,000 0,0840329 0,12087284 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,0840329 0,1207973 ! heart process GO:0003015 27 18 0,000 0,0840329 0,12072185 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,0840329 0,12064649 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,0840329 0,12057123 ! visual learning GO:0008542 35 18 0,000 0,0840329 0,12049606 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,0840329 0,12042098 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,0840329 0,120346 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,0840329 0,12027111 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,0840329 0,12019632 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,0840329 0,12012162 ! vitamin transport GO:0051180 24 18 0,000 0,0840329 0,12004701 ! hormone transport GO:0009914 27 18 0,000 0,0840329 0,11997249 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,0840329 0,11989806 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,0840329 0,11982373 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,0840329 0,11974949 ! cell-cell recognition GO:0009988 20 18 0,000 0,0840329 0,11967534 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,0840329 0,11960129 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,0840329 0,11952732 ! regulation of glucose import GO:0046324 21 18 0,000 0,0840329 0,11945345 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,0840329 0,11937967 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,0840329 0,11930597 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,0840329 0,11923237 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,0840329 0,11915886 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,08523026 0,12078226 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,08523026 0,12070788 ! protein localization in organelle GO:0033365 161 100 1,000 0,08523026 0,1206336 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,08523026 0,12055941 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,08849106 0,12509492 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,08849106 0,12501808 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,08849106 0,12494133 ! positive regulation of ossification GO:0045778 30 19 0,000 0,08849106 0,12486468 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,08849106 0,12478813 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,08849106 0,12471166 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,08849106 0,12463529 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,08849106 0,12455902 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,08849106 0,12448283 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,08849106 0,12440674 ! regeneration GO:0031099 32 19 0,000 0,08849106 0,12433075 ! response to alkaloid GO:0043279 32 19 0,000 0,08849106 0,12425484 ! sensory perception of taste GO:0050909 23 19 0,000 0,08849106 0,12417903 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,08849106 0,12410331 ! smooth muscle contraction GO:0006939 36 19 0,000 0,08849106 0,12402769 ! peroxisome organization GO:0007031 29 19 0,000 0,08849106 0,12395215 ! digestive system process GO:0022600 30 19 0,000 0,08849106 0,12387671 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,08849106 0,12380136 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,08849106 0,1237261 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,08849106 0,12365093 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,08849106 0,12357585 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,08849106 0,12350087 ! response to starvation GO:0042594 30 19 0,000 0,08849106 0,12342598 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,08849106 0,12335117 ! cytolysis GO:0019835 20 19 0,000 0,08849106 0,12327646 ! vasodilation GO:0042311 33 19 0,000 0,08849106 0,12320184 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,08849106 0,1231273 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,08849106 0,12305286 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,08849106 0,12297851 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,08849106 0,12290425 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,08849106 0,12283007 ! sarcomere organization GO:0045214 23 19 0,000 0,08849106 0,12275599 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,08849106 0,122682 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,08849106 0,12260809 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,08849106 0,12253428 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,08849106 0,12246055 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,08849106 0,12238691 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,08849106 0,12231336 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,08849106 0,1222399 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,09292777 0,12829164 ! iron ion transport GO:0006826 37 20 0,000 0,09292777 0,12821468 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,09292777 0,12813781 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,09292777 0,12806103 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,09292777 0,12798435 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,09292777 0,12790776 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,09292777 0,12783126 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,09292777 0,12775485 ! spinal cord development GO:0021510 31 20 0,000 0,09292777 0,12767853 ! response to ethanol GO:0045471 37 20 0,000 0,09292777 0,12760231 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,09292777 0,12752617 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,09292777 0,12745013 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,09292777 0,12737417 ! chromosome condensation GO:0030261 31 20 0,000 0,09292777 0,12729831 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,09292777 0,12722254 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,09292777 0,12714686 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,09292777 0,12707126 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,09292777 0,12699576 ! pallium development GO:0021543 38 20 0,000 0,09292777 0,12692035 ! collagen fibril organization GO:0030199 45 20 0,000 0,09292777 0,12684502 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,09292777 0,12676979 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,09292777 0,12669464 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,09292777 0,12661959 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,09292777 0,12654462 ! collagen catabolic process GO:0030574 25 20 0,000 0,09292777 0,12646974 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,09292777 0,12639495 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,09292777 0,12632025 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,09292777 0,12624564 ! alditol metabolic process GO:0019400 24 20 0,000 0,09292777 0,12617111 ! actin filament-based movement GO:0030048 34 20 0,000 0,09292777 0,12609668 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,09734313 0,13201015 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,09734313 0,13193236 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,09734313 0,13185466 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,09734313 0,13177705 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,09734313 0,13169953 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,09734313 0,13162211 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,09734313 0,13154478 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,09734313 0,13146753 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,09734313 0,13139038 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,09734313 0,13131332 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,09734313 0,13123635 ! vesicle docking GO:0048278 27 21 0,000 0,09734313 0,13115947 ! phototransduction GO:0007602 25 21 0,000 0,09734313 0,13108268 ! dendrite development GO:0016358 35 21 0,000 0,09734313 0,13100597 ! visual behavior GO:0007632 39 21 0,000 0,09734313 0,13092936 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,09734313 0,13085284 ! ovarian follicle development GO:0001541 30 21 0,000 0,09734313 0,13077641 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,09734313 0,13070006 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,09734313 0,13062381 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,09734313 0,13054764 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,09734313 0,13047157 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,09734313 0,13039558 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,09734313 0,13031968 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,09734313 0,13024387 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,09734313 0,13016815 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,09734313 0,13009251 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,09734313 0,13001696 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,09734313 0,1299415 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,09734313 0,12986613 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,09734313 0,12979085 ! fatty acid transport GO:0015908 30 21 0,000 0,09734313 0,12971565 ! immunoglobulin production GO:0002377 33 21 0,000 0,09734313 0,12964054 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,09734313 0,12956551 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,09734313 0,12949058 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,09734313 0,12941573 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,09734313 0,12934096 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,09734313 0,12926629 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,09734313 0,1291917 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,09734313 0,12911719 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,09734313 0,12904277 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,09734313 0,12896844 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,09734313 0,12889419 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,09734313 0,12882003 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,09734313 0,12874595 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,09734313 0,12867196 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,09734313 0,12859805 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,10173726 0,13432589 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,10173726 0,13424882 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,10173726 0,13417185 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,10173726 0,13409496 ! viral genome replication GO:0019079 29 22 0,000 0,10173726 0,13401816 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,10173726 0,13394144 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,10173726 0,13386482 ! leukocyte adhesion GO:0007159 38 22 0,000 0,10173726 0,13378828 ! molting cycle process GO:0022404 40 22 0,000 0,10173726 0,13371183 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,10173726 0,13363546 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,10173726 0,13355919 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,10173726 0,133483 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,10173726 0,1334069 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,10173726 0,13333088 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,10173726 0,13325495 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,10173726 0,13317911 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,10173726 0,13310336 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,10173726 0,13302769 ! lysosome organization GO:0007040 37 22 0,000 0,10173726 0,1329521 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,10173726 0,1328766 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,10173726 0,13280119 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,10173726 0,13272586 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,10173726 0,13265062 ! membrane depolarization GO:0051899 35 22 0,000 0,10173726 0,13257547 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,10173726 0,1325004 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,10173726 0,13242541 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,10173726 0,13235051 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,10173726 0,13227569 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,10173726 0,13220096 ! blastocyst development GO:0001824 37 22 0,000 0,10173726 0,13212631 ! neural tube closure GO:0001843 33 22 0,000 0,10173726 0,13205175 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,10173726 0,13197727 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,10611025 0,13757247 ! neuron fate commitment GO:0048663 32 23 0,000 0,10611025 0,13749497 ! embryonic pattern specification GO:0009880 31 23 0,000 0,10611025 0,13741755 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,10611025 0,13734022 ! myelination GO:0042552 35 23 0,000 0,10611025 0,13726297 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,10611025 0,13718582 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,10611025 0,13710875 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,10611025 0,13703176 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,10611025 0,13695486 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,10611025 0,13687805 ! vesicle targeting GO:0006903 32 23 0,000 0,10611025 0,13680133 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,10611025 0,13672469 ! osteoblast differentiation GO:0001649 40 23 0,000 0,10611025 0,13664813 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,10611025 0,13657167 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,10611025 0,13649528 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,10611025 0,13641899 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,10611025 0,13634277 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,10611025 0,13626665 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,10611025 0,13619061 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,10611025 0,13611465 ! cell fate determination GO:0001709 45 23 0,000 0,10611025 0,13603878 ! pentose metabolic process GO:0019321 31 23 0,000 0,10611025 0,13596299 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,10611025 0,13588729 ! spermatid development GO:0007286 33 23 0,000 0,10611025 0,13581167 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,10611025 0,13573613 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,10611025 0,13566068 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,10611025 0,13558531 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,10611025 0,13551003 ! telomere organization GO:0032200 32 23 0,000 0,10611025 0,13543483 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,10611025 0,13535972 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,10611025 0,13528468 ! regulation of amine transport GO:0051952 38 23 0,000 0,10611025 0,13520973 ! liver development GO:0001889 40 23 0,000 0,10611025 0,13513487 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,11046219 0,14059936 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,11046219 0,14052159 ! superoxide metabolic process GO:0006801 32 24 0,000 0,11046219 0,14044392 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,11046219 0,14036632 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,11046219 0,14028881 ! sperm motility GO:0030317 27 24 0,000 0,11046219 0,14021139 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,11046219 0,14013406 ! vacuole organization GO:0007033 39 24 0,000 0,11046219 0,1400568 ! receptor metabolic process GO:0043112 37 24 0,000 0,11046219 0,13997964 ! neural crest cell development GO:0014032 39 24 0,000 0,11046219 0,13990256 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,11046219 0,13982556 ! primary neural tube formation GO:0014020 35 24 0,000 0,11046219 0,13974865 ! negative regulation of cell development GO:0010721 56 24 0,000 0,11046219 0,13967182 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,11046219 0,13959508 ! base-excision repair GO:0006284 31 24 0,000 0,11046219 0,13951842 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,11046219 0,13944185 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,11046219 0,13936536 ! glutathione metabolic process GO:0006749 29 24 0,000 0,11046219 0,13928895 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,11046219 0,13921263 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,11046219 0,13913639 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,11046219 0,13906023 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,1147932 0,14443346 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,1147932 0,14435449 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,1147932 0,14427561 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,1147932 0,14419681 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,1147932 0,1441181 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,1147932 0,14403948 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,1147932 0,14396094 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,1147932 0,14388248 ! peptide transport GO:0015833 43 25 0,000 0,1147932 0,14380412 ! male gonad development GO:0008584 33 25 0,000 0,1147932 0,14372583 ! iron ion homeostasis GO:0055072 39 25 0,000 0,1147932 0,14364764 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,1147932 0,14356953 ! phospholipid transport GO:0015914 35 25 0,000 0,1147932 0,1434915 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,1147932 0,14341356 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,1147932 0,1433357 ! detection of light stimulus GO:0009583 30 25 0,000 0,1147932 0,14325793 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,1147932 0,14318024 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,1147932 0,14310263 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,11910337 0,14839531 ! translational initiation GO:0006413 43 26 0,000 0,11910337 0,14831497 ! regulation of pH GO:0006885 36 26 0,000 0,11910337 0,14823471 ! circadian rhythm GO:0007623 42 26 0,000 0,11910337 0,14815454 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,11910337 0,14807445 ! post-embryonic development GO:0009791 42 26 0,000 0,11910337 0,14799446 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,11910337 0,14791455 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,11910337 0,14783472 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,11910337 0,14775498 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,11910337 0,14767533 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,11910337 0,14759577 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,11910337 0,14751629 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,11910337 0,14743689 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,11910337 0,14735758 ! regulation of coagulation GO:0050818 39 26 0,000 0,11910337 0,14727836 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,12339279 0,15250049 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,12339279 0,15241859 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,12339279 0,15233678 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,12339279 0,15225505 ! membrane docking GO:0022406 39 27 0,000 0,12339279 0,15217342 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,12339279 0,15209187 ! catechol metabolic process GO:0009712 43 27 0,000 0,12339279 0,1520104 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,12339279 0,15192903 ! acute-phase response GO:0006953 42 27 0,000 0,12339279 0,15184774 ! myofibril assembly GO:0030239 36 27 0,000 0,12339279 0,15176653 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,12339279 0,15168542 ! response to ionizing radiation GO:0010212 47 27 0,000 0,12339279 0,15160439 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,12339279 0,15152345 ! natural killer cell activation GO:0030101 35 27 0,000 0,12339279 0,15144259 ! lipid oxidation GO:0034440 38 27 0,000 0,12339279 0,15136182 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,12339279 0,15128114 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,12339279 0,15120054 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,12339279 0,15112003 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,12339279 0,15103961 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,12339279 0,15095927 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,12339279 0,15087901 ! gene silencing GO:0016458 41 27 0,000 0,12339279 0,15079884 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,12766157 0,15593288 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,12766157 0,15585012 ! phenol metabolic process GO:0018958 44 28 0,000 0,12766157 0,15576744 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,12766157 0,15568485 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,12766157 0,15560234 ! cell junction assembly GO:0034329 56 28 0,000 0,12766157 0,15551993 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,12766157 0,1554376 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,12766157 0,15535536 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,12766157 0,1552732 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,12766157 0,15519113 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,12766157 0,15510915 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,12766157 0,15502726 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,12766157 0,15494545 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,12766157 0,15486372 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,12766157 0,15478209 ! mesoderm formation GO:0001707 46 28 0,000 0,12766157 0,15470054 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,12766157 0,15461907 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,12766157 0,1545377 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,12766157 0,1544564 ! ensheathment of neurons GO:0007272 43 28 0,000 0,12766157 0,1543752 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,12766157 0,15429407 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,12766157 0,15421304 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,12766157 0,15413208 ! neural tube formation GO:0001841 41 28 0,000 0,12766157 0,15405122 ! placenta development GO:0001890 37 28 0,000 0,12766157 0,15397044 ! regulation of B cell activation GO:0050864 42 28 0,000 0,12766157 0,15388974 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,13190981 0,15892749 ! regulation of innate immune response GO:0045088 38 29 0,000 0,13190981 0,15884428 ! ovulation cycle process GO:0022602 41 29 0,000 0,13190981 0,15876116 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,13190981 0,15867812 ! protein targeting to membrane GO:0006612 53 29 0,000 0,13190981 0,15859518 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,13190981 0,15851232 ! mismatch repair GO:0006298 34 29 0,000 0,13190981 0,15842954 ! muscle cell development GO:0055001 38 29 0,000 0,13190981 0,15834685 ! formation of primary germ layer GO:0001704 48 29 0,000 0,13190981 0,15826425 ! telencephalon development GO:0021537 52 29 0,000 0,13190981 0,15818174 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,13190981 0,15809931 ! eye morphogenesis GO:0048592 51 29 0,000 0,13190981 0,15801696 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,13190981 0,15793471 ! tissue homeostasis GO:0001894 42 29 0,000 0,13190981 0,15785253 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,13613761 0,16282709 ! collagen metabolic process GO:0032963 40 30 0,000 0,13613761 0,16274246 ! organic anion transport GO:0015711 51 30 0,000 0,13613761 0,16265792 ! cholesterol transport GO:0030301 46 30 0,000 0,13613761 0,16257347 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,13613761 0,1624891 ! spliceosome assembly GO:0000245 49 30 0,000 0,13613761 0,16240482 ! spindle organization GO:0007051 37 30 0,000 0,13613761 0,16232063 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,13613761 0,16223653 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,13613761 0,16215251 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,13613761 0,16206858 ! ceramide metabolic process GO:0006672 43 30 0,000 0,13613761 0,16198474 ! ovulation cycle GO:0042698 43 30 0,000 0,13613761 0,16190098 ! hindbrain development GO:0030902 45 30 0,000 0,13613761 0,16181731 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,13613761 0,16173373 ! adult locomotory behavior GO:0008344 47 30 0,000 0,13613761 0,16165023 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,13613761 0,16156682 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,13613761 0,16148349 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,13613761 0,16140026 ! response to heat GO:0009408 41 30 0,000 0,13613761 0,1613171 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,13613761 0,16123403 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,13613761 0,16115105 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,14034505 0,1660461 ! negative regulation of secretion GO:0051048 49 31 0,000 0,14034505 0,16596073 ! mammary gland development GO:0030879 57 31 0,000 0,14034505 0,16587544 ! glial cell differentiation GO:0010001 55 31 0,000 0,14034505 0,16579025 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,14034505 0,16570514 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,14034505 0,16562012 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,14034505 0,16553519 ! odontogenesis GO:0042476 50 31 0,000 0,14034505 0,16545034 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,14034505 0,16536558 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,14034505 0,16528091 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,14034505 0,16519632 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,14034505 0,16511182 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,14034505 0,16502741 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,14034505 0,16494308 ! cell fate specification GO:0001708 37 31 0,000 0,14034505 0,16485884 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,14034505 0,16477469 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,14034505 0,16469062 ! RNA modification GO:0009451 40 31 0,000 0,14034505 0,16460664 ! regulation of muscle development GO:0048634 48 32 0,000 0,14453224 0,16943127 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,14453224 0,16934496 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,14453224 0,16925873 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,14453224 0,1691726 ! meiosis I GO:0007127 52 32 0,000 0,14453224 0,16908655 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,14453224 0,16900059 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,14453224 0,16891471 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,14453224 0,16882893 ! peripheral nervous system development GO:0007422 53 32 0,000 0,14453224 0,16874323 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,14453224 0,16865761 ! cytokine production GO:0001816 44 32 0,000 0,14453224 0,16857209 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,14453224 0,16848665 ! vesicle localization GO:0051648 47 32 0,000 0,14453224 0,16840129 ! RNA export from nucleus GO:0006405 44 33 0,000 0,14869928 0,17316878 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,14869928 0,17308114 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,14869928 0,17299359 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,14869928 0,17290613 ! sister chromatid segregation GO:0000819 46 33 0,000 0,14869928 0,17281876 ! ear morphogenesis GO:0042471 42 33 0,000 0,14869928 0,17273148 ! actomyosin structure organization GO:0031032 43 33 0,000 0,14869928 0,17264429 ! cell junction organization GO:0034330 63 33 0,000 0,14869928 0,17255718 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,14869928 0,17247016 ! nucleus organization GO:0006997 49 33 0,000 0,14869928 0,17238323 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,14869928 0,17229639 ! female gonad development GO:0008585 49 33 0,000 0,14869928 0,17220963 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,14869928 0,17212297 ! positive regulation of cell development GO:0010720 54 33 0,000 0,14869928 0,17203639 ! lipid homeostasis GO:0055088 55 33 0,000 0,14869928 0,17194989 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,14869928 0,17186348 ! regulation of proteolysis GO:0030162 50 33 0,000 0,14869928 0,17177716 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,14869928 0,17169093 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,14869928 0,17160478 ! cytokinesis GO:0000910 52 33 0,000 0,14869928 0,17151872 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,14869928 0,17143275 ! mRNA catabolic process GO:0006402 48 34 0,000 0,15284625 0,17612544 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,15284625 0,17603724 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,15284625 0,17594914 ! feeding behavior GO:0007631 45 34 0,000 0,15284625 0,17586112 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,15284625 0,17577319 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,15284625 0,17568535 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,15284625 0,17559759 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,15284625 0,17550992 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,15284625 0,17542234 ! female gamete generation GO:0007292 43 34 0,000 0,15284625 0,17533485 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,15284625 0,17524745 ! polyol metabolic process GO:0019751 44 34 0,000 0,15284625 0,17516013 ! aerobic respiration GO:0009060 47 34 0,000 0,15284625 0,1750729 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,15284625 0,17498575 ! embryonic organ development GO:0048568 45 34 0,000 0,15284625 0,17489869 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,15284625 0,17481172 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,15697326 0,17944259 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,15697326 0,17935345 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,15697326 0,1792644 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,15697326 0,17917543 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,15697326 0,17908656 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,15697326 0,17899777 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,15697326 0,17890907 ! glycogen metabolic process GO:0005977 48 35 0,000 0,15697326 0,17882046 ! pigment metabolic process GO:0042440 61 35 0,000 0,15697326 0,17873193 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,15697326 0,17864349 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! cellular amide metabolic process GO:0043603 52 36 0,000 0,1610804 0,18322696 ! negative regulation of binding GO:0051100 58 36 0,000 0,1610804 0,18313639 ! neural tube development GO:0021915 50 36 0,000 0,1610804 0,18304591 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,1610804 0,18295552 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,1610804 0,18286521 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1610804 0,182775 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,1610804 0,18268487 ! glucan metabolic process GO:0044042 49 36 0,000 0,1610804 0,18259484 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,16516777 0,18713589 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,16516777 0,18704375 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,16516777 0,1869517 ! learning GO:0007612 67 37 0,000 0,16516777 0,18685974 ! ion transmembrane transport GO:0034220 56 37 0,000 0,16516777 0,18676788 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,16516777 0,1866761 ! regulation of protein secretion GO:0050708 51 37 0,000 0,16516777 0,18658441 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,16516777 0,18649281 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,16923545 0,19099192 ! gliogenesis GO:0042063 71 38 0,000 0,16923545 0,19089825 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,16923545 0,19080467 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,16923545 0,19071119 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,16923545 0,19061779 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,16923545 0,19052449 ! phagocytosis GO:0006909 60 38 0,000 0,16923545 0,19043128 ! maintenance of location in cell GO:0051651 69 38 0,000 0,16923545 0,19033816 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,17328355 0,19479577 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,17328355 0,19470061 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,17328355 0,19460554 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,17328355 0,19451057 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,17328355 0,19441568 ! male sex differentiation GO:0046661 53 39 0,000 0,17328355 0,19432089 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,17328355 0,1942262 ! chromatin remodeling GO:0006338 68 39 0,000 0,17328355 0,19413159 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,17328355 0,19403708 ! JNK cascade GO:0007254 54 39 0,000 0,17328355 0,19394265 ! developmental growth GO:0048589 62 39 0,000 0,17328355 0,19384832 ! cell growth GO:0016049 61 39 0,000 0,17328355 0,19375409 ! synapse organization GO:0050808 55 39 0,000 0,17328355 0,19365994 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,17731215 0,19806602 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,17731215 0,19796987 ! regulation of tube size GO:0035150 60 40 0,000 0,17731215 0,19787382 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,17731215 0,19777786 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,17731215 0,19768199 ! peptide metabolic process GO:0006518 56 40 0,000 0,17731215 0,19758621 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,17731215 0,19749053 ! inner ear development GO:0048839 57 40 0,000 0,17731215 0,19739494 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,17731215 0,19729944 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,17731215 0,19720403 ! double-strand break repair GO:0006302 67 40 0,000 0,17731215 0,19710872 ! B cell differentiation GO:0030183 62 40 0,000 0,17731215 0,1970135 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,17731215 0,19691837 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,18132135 0,2012737 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,18132135 0,2011766 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,18132135 0,2010796 ! glucose transport GO:0015758 52 41 0,000 0,18132135 0,2009827 ! endosome transport GO:0016197 71 41 0,000 0,18132135 0,20088589 ! striated muscle contraction GO:0006941 62 41 0,000 0,18132135 0,20078917 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,18132135 0,20069254 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,18132135 0,20059601 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,18132135 0,20049957 ! mitochondrial transport GO:0006839 60 42 0,000 0,18531124 0,204813 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,18531124 0,20471462 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,18531124 0,20461634 ! cellular component disassembly GO:0022411 64 42 0,000 0,18531124 0,20451816 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,18531124 0,20442007 ! hexose transport GO:0008645 54 42 0,000 0,18531124 0,20432207 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,18531124 0,20422417 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,18531124 0,20412636 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,18531124 0,20402865 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,18531124 0,20393103 ! leukocyte migration GO:0050900 60 43 0,000 0,18928191 0,20820105 ! neuromuscular process GO:0050905 79 43 0,000 0,18928191 0,20810153 ! tRNA processing GO:0008033 49 43 0,000 0,18928191 0,2080021 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,18928191 0,20790277 ! vesicle organization GO:0016050 79 43 0,000 0,18928191 0,20780353 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,19323346 0,21204053 ! glycolysis GO:0006096 53 44 0,000 0,19323346 0,21193942 ! regulation of action potential GO:0001508 71 44 0,000 0,19323346 0,2118384 ! regulation of ion transport GO:0043269 57 44 0,000 0,19323346 0,21173747 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,19323346 0,21163665 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,19323346 0,21153591 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,19323346 0,21143528 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,19323346 0,21133474 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,19323346 0,21123429 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,19323346 0,21113395 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,19323346 0,21103369 ! RNA catabolic process GO:0006401 64 45 0,000 0,19716597 0,21522626 ! positive regulation of defense response GO:0031349 59 45 0,000 0,19716597 0,21512416 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,19716597 0,21502216 ! cell recognition GO:0008037 58 45 0,000 0,19716597 0,21492025 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,20107954 0,2190824 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,20107954 0,21897867 ! cell redox homeostasis GO:0045454 63 46 0,000 0,20107954 0,21887503 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,20107954 0,2187715 ! regulation of ossification GO:0030278 71 46 0,000 0,20107954 0,21866806 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,20107954 0,21856472 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,20497425 0,22269286 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,20497425 0,22258772 ! endocrine system development GO:0035270 83 47 0,000 0,20497425 0,22248267 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,20497425 0,22237773 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,20497425 0,22227288 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,20497425 0,22216814 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,20497425 0,22206349 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 0,000 0,20497425 0,22195894 ! chloride transport GO:0006821 67 48 0,000 0,2088502 0,22604963 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,2088502 0,22594331 ! response to temperature stimulus GO:0009266 62 48 0,000 0,2088502 0,22583708 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,2088502 0,22573095 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,2088502 0,22562493 ! gastrulation GO:0007369 73 48 0,000 0,2088502 0,225519 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,2088502 0,22541317 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,2088502 0,22530744 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,2088502 0,22520181 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,2088502 0,22509628 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,2088502 0,22499085 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,21270748 0,22903895 ! sensory perception of smell GO:0007608 61 49 0,000 0,21270748 0,22893177 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,21270748 0,2288247 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,21270748 0,22871772 ! cartilage development GO:0051216 70 49 0,000 0,21270748 0,22861084 ! regulation of actin filament length GO:0030832 72 50 0,000 0,21654617 0,23262783 ! ear development GO:0043583 72 50 0,000 0,21654617 0,23251923 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,21654617 0,23241073 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,21654617 0,23230233 ! proton transport GO:0015992 75 50 0,000 0,21654617 0,23219403 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,21654617 0,23208583 ! hydrogen transport GO:0006818 77 51 0,000 0,22036636 0,23607016 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,22036636 0,23596025 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,22036636 0,23585045 ! adult behavior GO:0030534 80 51 0,000 0,22036636 0,23574076 ! transition metal ion transport GO:0000041 74 52 0,000 0,22416814 0,23969629 ! regulation of cellular component size GO:0032535 74 52 0,000 0,22416814 0,23958491 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,22416814 0,23947363 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,22416814 0,23936245 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,2279516 0,24328941 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,2279516 0,24317657 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,2279516 0,24306383 ! single fertilization GO:0007338 59 53 0,000 0,2279516 0,2429512 ! amino acid transport GO:0006865 84 54 0,000 0,23171683 0,24684979 ! glucose catabolic process GO:0006007 66 54 0,000 0,23171683 0,24673551 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,23171683 0,24662133 ! DNA catabolic process GO:0006308 67 54 0,000 0,23171683 0,24650726 ! detection of external stimulus GO:0009581 66 54 0,000 0,23171683 0,2463933 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,23171683 0,24627944 ! exocytosis GO:0006887 74 55 0,000 0,2354639 0,25014641 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,2354639 0,25003092 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,2354639 0,24991554 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,23919292 0,25375633 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,24290396 0,25757451 ! carbohydrate transport GO:0008643 74 57 0,000 0,24290396 0,25745581 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,24290396 0,25733722 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,24290396 0,25721874 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,24290396 0,25710037 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,24290396 0,25698211 ! camera-type eye development GO:0043010 88 57 0,000 0,24290396 0,25686396 ! secondary metabolic process GO:0019748 84 57 0,000 0,24290396 0,25674592 ! gonad development GO:0008406 79 57 0,000 0,24290396 0,25662798 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,24659711 0,26041017 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,24659711 0,26029067 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,25027246 0,26404893 ! actin filament organization GO:0007015 95 59 0,000 0,25027246 0,26392786 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,25393009 0,26766233 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,25393009 0,26753972 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,25393009 0,26741722 ! regulation of heart contraction GO:0008016 91 60 0,000 0,25393009 0,26729483 ! fertilization GO:0009566 68 60 0,000 0,25393009 0,26717255 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,25757008 0,27087846 ! meiosis GO:0007126 96 61 0,000 0,25757008 0,27075465 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,25757008 0,27063097 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,25757008 0,27050739 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,25757008 0,27038393 ! extracellular matrix organization GO:0030198 103 61 0,000 0,25757008 0,27026058 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,25757008 0,27013734 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,25757008 0,27001421 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,25757008 0,2698912 ! amine catabolic process GO:0009310 90 62 0,000 0,26119252 0,27356229 ! neurotransmitter transport GO:0006836 81 62 0,000 0,26119252 0,27343778 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,26119252 0,27331337 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,26119252 0,27318908 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,26119252 0,27306491 ! meiotic cell cycle GO:0051321 97 62 0,000 0,26119252 0,27294084 ! appendage morphogenesis GO:0035107 93 64 0,000 0,26838508 0,28032956 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,26838508 0,28020231 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,26838508 0,28007518 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,26838508 0,27994816 ! hexose catabolic process GO:0019320 82 64 0,000 0,26838508 0,27982126 ! reproductive structure development GO:0048608 90 65 0,000 0,27195537 0,2834152 ! appendage development GO:0048736 94 65 0,000 0,27195537 0,28328684 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,27195537 0,2831586 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,27195537 0,28303048 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,27195537 0,28290247 ! defense response to bacterium GO:0042742 73 65 0,000 0,27195537 0,28277457 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,27195537 0,28264679 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,27195537 0,28251913 ! activation of immune response GO:0002253 83 65 0,000 0,27195537 0,28239158 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,27550844 0,2859519 ! regulation of immune effector process GO:0002697 101 66 0,000 0,27550844 0,28582292 ! acute inflammatory response GO:0002526 92 68 0,000 0,28256325 0,29300968 ! learning or memory GO:0007611 123 68 0,000 0,28256325 0,29287763 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,28256325 0,29274571 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,28256325 0,2926139 ! rhythmic process GO:0048511 105 68 0,000 0,28256325 0,29248221 ! inorganic anion transport GO:0015698 93 68 0,000 0,28256325 0,29235064 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,28606515 0,29584076 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,28606515 0,29570779 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,28606515 0,29557495 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,28955016 0,29904147 ! humoral immune response GO:0006959 86 70 0,000 0,28955016 0,29890725 ! eye development GO:0001654 111 70 0,000 0,28955016 0,29877315 ! amine transport GO:0015837 101 70 0,000 0,28955016 0,29863918 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,29301835 0,30208078 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,29301835 0,30194544 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,29301835 0,30181022 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,29301835 0,30167512 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,29301835 0,30154014 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,29646982 0,30495554 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,29646982 0,30481921 ! negative regulation of transport GO:0051051 116 73 0,000 0,29990463 0,30821298 ! mitochondrion organization GO:0007005 104 73 0,000 0,29990463 0,30807532 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,29990463 0,30793779 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,30332287 0,31130861 ! digestion GO:0007586 97 74 0,000 0,30332287 0,31116976 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,30332287 0,31103103 ! regulation of ligase activity GO:0051340 114 75 0,000 0,30672461 0,31437906 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,30672461 0,31423902 ! amine biosynthetic process GO:0009309 97 76 0,000 0,31010994 0,31756583 ! response to unfolded protein GO:0006986 99 76 0,000 0,31010994 0,3174245 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,31347893 0,32073022 ! gland development GO:0048732 148 77 0,000 0,31347893 0,32058761 ! sex differentiation GO:0007548 105 77 0,000 0,31347893 0,32044513 ! protein ubiquitination GO:0016567 125 77 0,000 0,31347893 0,32030277 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,31347893 0,32016054 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,31347893 0,32001844 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,31683166 0,32329761 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,31683166 0,32315424 ! cellular respiration GO:0045333 107 79 0,000 0,32016821 0,32641263 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,32016821 0,326268 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,32016821 0,32612351 ! chromatin assembly GO:0031497 102 80 0,000 0,32348866 0,32935985 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,32348866 0,32921412 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,32348866 0,32906851 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,32348866 0,32892304 ! forebrain development GO:0030900 131 80 0,000 0,32348866 0,32877769 ! response to protein stimulus GO:0051789 111 81 0,000 0,32679307 0,33198943 ! regulation of neurological system process GO:0031644 122 81 0,000 0,32679307 0,33184286 ! vitamin metabolic process GO:0006766 103 81 0,000 0,32679307 0,33169641 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,32679307 0,3315501 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 0,000 0,33008154 0,33473877 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,33335413 0,33790855 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,33335413 0,33775969 ! regulation of defense response GO:0031347 117 84 0,000 0,33661092 0,34090934 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,33661092 0,34075929 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,33661092 0,34060938 ! sterol metabolic process GO:0016125 120 84 0,000 0,33661092 0,34045959 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,33985199 0,34358662 ! regulation of membrane potential GO:0042391 128 85 0,000 0,33985199 0,34343566 ! nucleosome organization GO:0034728 114 87 0,000 0,34628725 0,3497851 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,34628725 0,34963155 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,34628725 0,34947813 ! female pregnancy GO:0007565 130 87 0,000 0,34628725 0,34932485 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,34948159 0,35239266 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,34948159 0,35223823 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,34948159 0,35208395 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,3526605 0,35513098 ! regulation of T cell activation GO:0050863 128 89 0,000 0,3526605 0,35497556 ! hormone metabolic process GO:0042445 121 90 0,000 0,35582407 0,35800322 ! ATP metabolic process GO:0046034 137 91 0,000 0,35897235 0,36101286 ! positive regulation of immune response GO:0050778 121 92 0,000 0,36210543 0,36400458 ! DNA recombination GO:0006310 146 92 0,000 0,36210543 0,36384556 ! sulfur metabolic process GO:0006790 118 92 0,000 0,36210543 0,36368667 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,36522337 0,36665812 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,36522337 0,36649815 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,36522337 0,36633831 ! electron transport chain GO:0022900 123 94 0,000 0,36832625 0,36928962 ! carboxylic acid transport GO:0046942 147 95 0,000 0,37141415 0,37222333 GO:0015849|organic acid transport, ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,37754525 0,37820299 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,38361724 0,38411827 ! extracellular structure organization GO:0043062 156 99 0,000 0,38361724 0,38395111 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,38663125 0,38679943 ! divalent metal ion transport GO:0070838 171 100 0,000 0,38663125 0,38663125