pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1102-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of epithelial cell proliferation GO:0050678 71 39 6,000 3,044E-10 7E-07 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 4,000 5,414E-08 6,226E-05 ! ribosomal large subunit biogenesis GO:0042273 12 12 3,000 1,59E-07 1,219E-04 ! cell growth GO:0016049 61 39 4,000 6,97E-07 4,008E-04 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 3,000 1,216E-06 5,596E-04 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 1,216E-06 4,663E-04 ! positive regulation of protein ubiquitination GO:0031398 8 6 2,000 1,564E-06 5,14E-04 ! regulation of epidermal cell differentiation GO:0045604 7 6 2,000 1,564E-06 4,498E-04 ! Wnt receptor signaling pathway GO:0016055 130 87 5,000 2,11E-06 5,392E-04 ! positive regulation of epidermis development GO:0045684 11 7 2,000 2,729E-06 6,277E-04 ! UTP metabolic process GO:0046051 8 8 2,000 4,353E-06 9,102E-04 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! CTP metabolic process GO:0046036 9 9 2,000 6,509E-06 1,248E-03 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 9 9 2,000 6,509E-06 1,152E-03 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 2,000 9,269E-06 1,523E-03 ! detection of bacterium GO:0016045 10 10 2,000 9,269E-06 1,421E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 1,271E-05 1,826E-03 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 2,000 1,689E-05 2,285E-03 ! regulation of epidermis development GO:0045682 17 12 2,000 1,689E-05 2,158E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 2,189E-05 2,649E-03 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 2,000 2,777E-05 3,193E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 2,777E-05 3,041E-03 ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 2,777E-05 2,903E-03 ! rRNA metabolic process GO:0016072 107 85 4,000 3,399E-05 3,399E-03 GO:0006364|rRNA processing, ! regulation of protein ubiquitination GO:0031396 19 15 2,000 3,46E-05 3,316E-03 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 2,000 3,46E-05 3,183E-03 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 2,000 4,245E-05 3,755E-03 ! detection of biotic stimulus GO:0009595 19 16 2,000 4,245E-05 3,616E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 4,245E-05 3,487E-03 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 6,147E-05 4,875E-03 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 2,000 7,277E-05 5,579E-03 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 2,000 9,926E-05 7,364E-03 ! lung development GO:0030324 94 59 3,000 1,252E-04 9,001E-03 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,313E-04 9,154E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 1,496E-04 0,01012284 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 1,496E-04 9,834E-03 ! respiratory tube development GO:0030323 99 62 3,000 1,52E-04 9,71E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,618E-04 0,0100551 ! iron ion homeostasis GO:0055072 39 25 2,000 1,695E-04 0,01026023 ! respiratory system development GO:0060541 100 64 3,000 1,72E-04 0,01014207 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 1,849E-04 0,01063418 ! embryonic hemopoiesis GO:0035162 10 5 1,000 1,849E-04 0,01037481 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,849E-04 0,01012779 ! microvillus organization GO:0032528 7 5 1,000 1,849E-04 9,892E-03 GO:0030033|microvillus assembly, ! 5S class rRNA transcription GO:0042791 8 5 1,000 1,849E-04 9,667E-03 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! positive regulation of chemokine production GO:0032722 7 5 1,000 1,849E-04 9,453E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 1,849E-04 9,247E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 1,849E-04 9,05E-03 GO:0051930|regulation of sensory perception of pain, ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 1,849E-04 8,862E-03 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 2,433E-04 0,01142176 ! steroid biosynthetic process GO:0006694 94 71 3,000 2,57E-04 0,01182274 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 2,712E-04 0,01223255 GO:0045937|positive regulation of phosphate metabolic process, ! tRNA transcription GO:0009304 11 6 1,000 2,766E-04 0,01223561 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,766E-04 0,01200475 ! establishment of tissue polarity GO:0007164 7 6 1,000 2,766E-04 0,01178244 ! drug transport GO:0015893 6 6 1,000 2,766E-04 0,01156822 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 2,766E-04 0,01136164 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 2,766E-04 0,01116232 ! gas homeostasis GO:0033483 11 6 1,000 2,766E-04 0,01096986 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 2,766E-04 0,01078393 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 2,766E-04 0,0106042 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 2,766E-04 0,01043036 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,862E-04 0,01432648 ! hemoglobin metabolic process GO:0020027 10 7 1,000 3,862E-04 0,01409908 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 3,862E-04 0,01387878 ! peptidyl-threonine modification GO:0018210 18 7 1,000 3,862E-04 0,01366526 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 2,000 3,922E-04 0,01366752 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 5,135E-04 0,01762665 ! pseudouridine synthesis GO:0001522 9 8 1,000 5,135E-04 0,01736743 ! induction of an organ GO:0001759 11 8 1,000 5,135E-04 0,01711573 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 5,135E-04 0,01687122 ! ribonucleoside metabolic process GO:0009119 48 37 2,000 5,516E-04 0,01786901 ! anatomical structure homeostasis GO:0060249 136 88 3,000 5,834E-04 0,01863643 ! mesenchymal cell development GO:0014031 64 38 2,000 5,97E-04 0,01881035 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 6,583E-04 0,02046125 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 6,583E-04 0,02018843 ! regulation of glycolysis GO:0006110 15 9 1,000 6,583E-04 0,01992279 ! telomere maintenance via telomerase GO:0007004 12 9 1,000 6,583E-04 0,01966406 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of hormone metabolic process GO:0032350 15 9 1,000 6,583E-04 0,01941195 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 6,583E-04 0,01916623 ! embryonic placenta development GO:0001892 12 9 1,000 6,583E-04 0,01892665 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 6,583E-04 0,01869299 ! localization within membrane GO:0051668 15 9 1,000 6,583E-04 0,01846503 ! inner ear development GO:0048839 57 40 2,000 6,949E-04 0,01925543 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 6,949E-04 0,0190262 ! JAK-STAT cascade GO:0007259 53 40 2,000 6,949E-04 0,01880236 ! epithelial cell differentiation GO:0030855 55 41 2,000 7,474E-04 0,01998845 ! positive regulation of DNA binding GO:0043388 57 41 2,000 7,474E-04 0,0197587 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 8,206E-04 0,02144699 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 8,206E-04 0,02120602 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 8,206E-04 0,02097039 ! RNA-dependent DNA replication GO:0006278 13 10 1,000 8,206E-04 0,02073995 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 8,206E-04 0,02051452 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 8,206E-04 0,02029393 GO:0045168|cell-cell signaling involved in cell fate specification, ! positive regulation of binding GO:0051099 59 43 2,000 8,599E-04 0,0210395 ! positive regulation of cell cycle GO:0045787 77 45 2,000 9,826E-04 0,0237884 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 9,826E-04 0,0235406 ! rRNA transcription GO:0009303 17 11 1,000 1E-03 0,02371391 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 1E-03 0,02347193 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 1E-03 0,02323484 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 1E-03 0,02300249 ! stem cell development GO:0048864 29 11 1,000 1E-03 0,02277475 GO:0019827|stem cell maintenance, ! regulation of protein polymerization GO:0032271 71 47 2,000 1,116E-03 0,02516041 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 1,186E-03 0,02649458 ! lactation GO:0007595 20 12 1,000 1,197E-03 0,02646664 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,197E-03 0,02621458 ! phospholipid catabolic process GO:0009395 14 12 1,000 1,197E-03 0,02596727 ! heart looping GO:0001947 15 12 1,000 1,197E-03 0,02572459 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,197E-03 0,0254864 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,197E-03 0,02525258 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,197E-03 0,02502301 ! ear development GO:0043583 72 50 2,000 1,336E-03 0,0276871 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,41E-03 0,02896285 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 1,41E-03 0,02870654 ! cGMP metabolic process GO:0046068 16 13 1,000 1,41E-03 0,02845473 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 1,000 1,41E-03 0,02820729 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 1,000 1,41E-03 0,02796413 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,41E-03 0,02772512 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,415E-03 0,02758644 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,415E-03 0,02735462 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 1,641E-03 0,03144862 ! startle response GO:0001964 21 14 1,000 1,641E-03 0,03118871 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 1,641E-03 0,03093307 ! muscle maintenance GO:0046716 19 14 1,000 1,641E-03 0,03068158 ! regulation of protein complex assembly GO:0043254 81 54 2,000 1,67E-03 0,03097698 ! cytokine-mediated signaling pathway GO:0019221 76 54 2,000 1,67E-03 0,03072916 ! detection of external stimulus GO:0009581 66 54 2,000 1,67E-03 0,03048528 ! nucleoside metabolic process GO:0009116 69 55 2,000 1,761E-03 0,03189081 ! positive regulation of cell motion GO:0051272 99 56 2,000 1,855E-03 0,0333289 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 1,888E-03 0,03366032 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,152E-03 0,03806572 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,152E-03 0,03777514 ! neural crest cell migration GO:0001755 24 16 1,000 2,152E-03 0,03748897 ! G1 phase GO:0051318 27 16 1,000 2,152E-03 0,0372071 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,152E-03 0,03692943 ! regulation of homeostatic process GO:0032844 105 60 2,000 2,261E-03 0,03852869 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 2,432E-03 0,04112199 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 2,432E-03 0,04082183 ! stem cell differentiation GO:0048863 36 17 1,000 2,432E-03 0,04052602 ! peptidyl-serine modification GO:0018209 27 17 1,000 2,432E-03 0,04023447 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 2,719E-03 0,04467607 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 2,728E-03 0,04449639 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 2,728E-03 0,04418304 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 2,728E-03 0,04387406 ! somitogenesis GO:0001756 24 18 1,000 2,728E-03 0,04356938 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 3,04E-03 0,04822356 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 3,04E-03 0,04789326 GO:0010675|regulation of cellular carbohydrate metabolic process, ! vasodilation GO:0042311 33 19 1,000 3,04E-03 0,04756746 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 3,04E-03 0,04724606 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 3,04E-03 0,04692897 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 3,04E-03 0,04661611 ! response to drug GO:0042493 108 69 2,000 3,367E-03 0,05128699 ! protein amino acid O-linked glycosylation GO:0006493 29 20 1,000 3,368E-03 0,05097067 ! iron ion transport GO:0006826 37 20 1,000 3,368E-03 0,05063752 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 3,368E-03 0,05030871 ! protein amino acid acylation GO:0043543 37 21 1,000 3,713E-03 0,05509059 ! response to hypoxia GO:0001666 132 72 2,000 3,797E-03 0,0559854 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 4,072E-03 0,05965983 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 4,072E-03 0,05928224 ! viral genome replication GO:0019079 29 22 1,000 4,072E-03 0,05890939 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 4,072E-03 0,05854121 GO:0010810|regulation of cell-substrate adhesion, ! barbed-end actin filament capping GO:0051016 33 22 1,000 4,072E-03 0,0581776 GO:0051693|actin filament capping, ! response to oxygen levels GO:0070482 137 74 2,000 4,102E-03 0,05823578 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 4,448E-03 0,06275999 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 4,448E-03 0,06237731 ! cellular response to oxidative stress GO:0034599 33 23 1,000 4,448E-03 0,06199926 ! cell fate determination GO:0001709 45 23 1,000 4,448E-03 0,06162577 ! telomere organization GO:0032200 32 23 1,000 4,448E-03 0,06125676 GO:0000723|telomere maintenance, ! regulation of DNA binding GO:0051101 119 77 2,000 4,586E-03 0,06278226 ! positive regulation of protein modification process GO:0031401 107 78 2,000 4,755E-03 0,06470645 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 4,839E-03 0,06546223 ! sperm motility GO:0030317 27 24 1,000 4,839E-03 0,06507941 ! neural crest cell development GO:0014032 39 24 1,000 4,839E-03 0,06470104 GO:0014033|neural crest cell differentiation, ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 4,839E-03 0,06432705 ! forebrain development GO:0030900 131 80 2,000 5,103E-03 0,06745405 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 5,245E-03 0,06892787 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 5,245E-03 0,06853624 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 1,000 5,245E-03 0,06814903 ! detection of stimulus GO:0051606 108 82 2,000 5,467E-03 0,07063593 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 5,666E-03 0,07279867 ! post-embryonic development GO:0009791 42 26 1,000 5,666E-03 0,07239423 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 5,666E-03 0,07199427 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 5,666E-03 0,07159869 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 6,102E-03 0,07668863 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 6,24E-03 0,07799397 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 2,000 6,442E-03 0,08009474 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! negative regulation of protein complex assembly GO:0031333 42 28 1,000 6,553E-03 0,08102817 ! mesoderm formation GO:0001707 46 28 1,000 6,553E-03 0,08059486 ! positive regulation of catabolic process GO:0009896 40 28 1,000 6,553E-03 0,08016617 ! placenta development GO:0001890 37 28 1,000 6,553E-03 0,07974201 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 2,000 6,649E-03 0,08049021 ! interphase GO:0051325 159 88 2,000 6,649E-03 0,0800688 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 2,000 6,86E-03 0,0821759 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 7,018E-03 0,08363894 ! formation of primary germ layer GO:0001704 48 29 1,000 7,018E-03 0,08320781 ! collagen metabolic process GO:0032963 40 30 1,000 7,499E-03 0,08844585 ! adult locomotory behavior GO:0008344 47 30 1,000 7,499E-03 0,08799459 ! regulation of microtubule-based process GO:0032886 58 30 1,000 7,499E-03 0,08754792 ! cell fate commitment GO:0045165 141 92 2,000 7,516E-03 0,08730399 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 7,742E-03 0,08948393 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 7,742E-03 0,08903651 ! mammary gland development GO:0030879 57 31 1,000 7,993E-03 0,09146672 ! segmentation GO:0035282 41 31 1,000 7,993E-03 0,09101391 ! mesoderm morphogenesis GO:0048332 49 31 1,000 7,993E-03 0,09056557 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 7,993E-03 0,09012162 ! cell fate specification GO:0001708 37 31 1,000 7,993E-03 0,089682 ! leukocyte chemotaxis GO:0030595 43 31 1,000 7,993E-03 0,08924665 GO:0060326|cell chemotaxis, ! RNA modification GO:0009451 40 31 1,000 7,993E-03 0,08881551 ! regulation of binding GO:0051098 151 95 2,000 8,207E-03 0,09075585 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 8,446E-03 0,0929478 ! calcium-mediated signaling GO:0019722 50 32 1,000 8,502E-03 0,09312201 ! carbohydrate homeostasis GO:0033500 39 33 1,000 9,026E-03 0,09838426 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 9,026E-03 0,09792018 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 9,026E-03 0,09746046 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 2,000 9,441E-03 0,10147273 ! neuron migration GO:0001764 46 34 1,000 9,563E-03 0,10230176 ! embryonic organ development GO:0048568 45 34 1,000 9,563E-03 0,10182814 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,01011423 0,10720151 ! cyclic nucleotide metabolic process GO:0009187 58 35 1,000 0,01011423 0,10670976 ! protein homooligomerization GO:0051260 52 35 1,000 0,01011423 0,1062225 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01067927 0,11164696 GO:0090047|positive regulation of transcription regulator activity, ! tissue remodeling GO:0048771 62 36 1,000 0,01067927 0,11114177 ! amino acid activation GO:0043038 52 37 1,000 0,011258 0,11663692 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! gliogenesis GO:0042063 71 38 1,000 0,01185027 0,12222256 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,01245598 0,1278962 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,01245598 0,12732778 ! chromatin remodeling GO:0006338 68 39 1,000 0,01245598 0,12676438 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,01307498 0,13247781 ! regulation of tube size GO:0035150 60 40 1,000 0,01307498 0,13189677 GO:0050880|regulation of blood vessel size, ! B cell differentiation GO:0030183 62 40 1,000 0,01307498 0,1313208 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,01307498 0,13074984 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01307498 0,13018382 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,01435241 0,1422868 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,01501058 0,1481731 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,01501058 0,14753988 ! leukocyte migration GO:0050900 60 43 1,000 0,01501058 0,14691205 ! neuromuscular process GO:0050905 79 43 1,000 0,01501058 0,14628955 ! regulation of translational initiation GO:0006446 64 45 1,000 0,01636524 0,15881876 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,01636524 0,15815146 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,01706148 0,16419 ! regulation of ossification GO:0030278 71 46 1,000 0,01706148 0,16350588 ! histone modification GO:0016570 68 46 1,000 0,01706148 0,16282743 ! response to UV GO:0009411 75 46 1,000 0,01706148 0,16215459 ! viral infectious cycle GO:0019058 71 47 1,000 0,01777018 0,16819511 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01777018 0,16750579 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01777018 0,16682209 ! chloride transport GO:0006821 67 48 1,000 0,01849121 0,17288529 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,01849121 0,17218535 ! gastrulation GO:0007369 73 48 1,000 0,01849121 0,17149105 ! heart morphogenesis GO:0003007 65 48 1,000 0,01849121 0,17080233 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,01849121 0,17011912 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,01922445 0,17616034 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,01922445 0,17546129 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,01922445 0,17476776 ! cartilage development GO:0051216 70 49 1,000 0,01922445 0,1740797 ! regulation of actin filament length GO:0030832 72 50 1,000 0,0199698 0,18011975 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,0199698 0,17941615 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,02072712 0,18549566 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,02072712 0,18477669 ! adult behavior GO:0030534 80 51 1,000 0,02072712 0,18406326 ! transition metal ion transport GO:0000041 74 52 1,000 0,02149632 0,19015973 ! regulation of cellular component size GO:0032535 74 52 1,000 0,02149632 0,18943115 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,02149632 0,18870813 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02155091 0,18846808 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02155091 0,18775418 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02155091 0,18704568 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02155091 0,1863425 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02155091 0,18564458 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02155091 0,18495188 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02155091 0,18426433 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02155091 0,18358187 ! sleep GO:0030431 11 5 0,000 0,02155091 0,18290444 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02155091 0,182232 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02155091 0,18156448 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02155091 0,18090184 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02155091 0,18024401 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02155091 0,17959096 ! tongue development GO:0043586 6 5 0,000 0,02155091 0,17894261 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02155091 0,17829894 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02155091 0,17765987 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02155091 0,17702537 ! cobalt ion transport GO:0006824 9 5 0,000 0,02155091 0,17639539 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02155091 0,17576987 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02155091 0,17514878 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02155091 0,17453206 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02155091 0,17391966 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02155091 0,17331155 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02155091 0,17270768 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02155091 0,172108 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02155091 0,17151247 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02155091 0,17092105 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02155091 0,17033369 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02155091 0,16975036 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02155091 0,169171 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02155091 0,16859559 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02155091 0,16802408 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02155091 0,16745643 ! malate metabolic process GO:0006108 7 5 0,000 0,02155091 0,16689261 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02155091 0,16633256 ! behavioral response to pain GO:0048266 7 5 0,000 0,02155091 0,16577627 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02155091 0,16522368 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02155091 0,16467476 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02155091 0,16412948 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02155091 0,1635878 ! mating behavior GO:0007617 6 5 0,000 0,02155091 0,16304968 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02155091 0,16251509 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02155091 0,161984 ! rhythmic behavior GO:0007622 12 5 0,000 0,02155091 0,16145636 ! copulation GO:0007620 7 5 0,000 0,02155091 0,16093216 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02155091 0,16041134 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02155091 0,15989388 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02155091 0,15937976 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02155091 0,15886892 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02155091 0,15836135 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02155091 0,15785702 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02155091 0,15735589 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02155091 0,15685792 ! response to protozoan GO:0001562 9 5 0,000 0,02155091 0,1563631 ! lymph vessel development GO:0001945 7 5 0,000 0,02155091 0,1558714 ! endochondral ossification GO:0001958 12 5 0,000 0,02155091 0,15538277 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02155091 0,1548972 ! parathyroid gland development GO:0060017 8 5 0,000 0,02155091 0,15441465 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02155091 0,15393511 ! anagen GO:0042640 6 5 0,000 0,02155091 0,15345853 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02155091 0,15298489 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02155091 0,15251417 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02155091 0,15204633 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02155091 0,15158136 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02155091 0,15111922 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02155091 0,15065989 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02155091 0,15020335 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02155091 0,14974956 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02155091 0,14929851 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02155091 0,14885016 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02155091 0,1484045 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02155091 0,1479615 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02155091 0,14752114 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02155091 0,14708339 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02155091 0,14664824 ! ovulation GO:0030728 6 5 0,000 0,02155091 0,14621565 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02155091 0,1457856 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,02155091 0,14535808 ! response to pH GO:0009268 9 5 0,000 0,02155091 0,14493305 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02155091 0,14451051 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02155091 0,14409042 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02155091 0,14367277 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02155091 0,14325753 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02155091 0,14284468 ! polyol catabolic process GO:0046174 7 5 0,000 0,02155091 0,14243421 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02155091 0,14202609 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02155091 0,1416203 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02155091 0,14121682 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02155091 0,14081564 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02155091 0,14041673 ! urea metabolic process GO:0019627 6 5 0,000 0,02155091 0,14002007 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02155091 0,13962564 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02155091 0,13923344 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02155091 0,13884343 ! neutrophil activation GO:0042119 5 5 0,000 0,02155091 0,1384556 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02155091 0,13806993 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02155091 0,1376864 ! response to food GO:0032094 5 5 0,000 0,02155091 0,137305 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02155091 0,1369257 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02155091 0,1365485 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02155091 0,13617336 ! forebrain neuron development GO:0021884 7 5 0,000 0,02155091 0,13580028 ! melanosome organization GO:0032438 7 5 0,000 0,02155091 0,13542925 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02155091 0,13506023 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02155091 0,13469322 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02155091 0,1343282 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02155091 0,13396515 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02155091 0,13360405 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02155091 0,1332449 ! nucleoside transport GO:0015858 6 5 0,000 0,02155091 0,13288768 ! nucleoside salvage GO:0043174 7 5 0,000 0,02155091 0,13253236 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02155091 0,13217894 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02155091 0,1318274 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02155091 0,13147773 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02155091 0,1311299 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02155091 0,13078392 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02155091 0,13043975 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02155091 0,13009739 ! depyrimidination GO:0045008 8 5 0,000 0,02155091 0,12975682 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02155091 0,12941803 ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02155091 0,129081 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02155091 0,12874572 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02155091 0,12841219 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02155091 0,12808037 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02155091 0,12775027 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02155091 0,12742186 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02155091 0,12709514 ! monocyte differentiation GO:0030224 8 5 0,000 0,02155091 0,12677009 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02155091 0,12644669 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02155091 0,12612495 ! centrosome duplication GO:0051298 5 5 0,000 0,02155091 0,12580483 ! response to UV-C GO:0010225 6 5 0,000 0,02155091 0,12548634 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02155091 0,12516945 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02155091 0,12485417 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02155091 0,12454046 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02155091 0,12422833 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02155091 0,12391776 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02155091 0,12360874 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02155091 0,12330125 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02155091 0,1229953 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02155091 0,12269085 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02155091 0,12238791 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02155091 0,12208646 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02155091 0,1217865 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02155091 0,121488 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02155091 0,12119096 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02155091 0,12089538 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02155091 0,12060123 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02155091 0,1203085 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02155091 0,1200172 ! neural tube patterning GO:0021532 6 5 0,000 0,02155091 0,1197273 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02155091 0,1194388 ! histone demethylation GO:0016577 9 5 0,000 0,02155091 0,11915169 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02155091 0,11886596 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02155091 0,11858159 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02155091 0,11829858 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02155091 0,11801691 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02155091 0,11773659 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02155091 0,11745759 ! transcription termination GO:0006353 8 5 0,000 0,02155091 0,11717991 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02155091 0,11690355 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02155091 0,11662848 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02155091 0,1163547 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,02155091 0,11608221 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02155091 0,11581099 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02155091 0,11554103 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02155091 0,11527233 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02155091 0,11500488 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02155091 0,11473867 ! apical protein localization GO:0045176 6 5 0,000 0,02155091 0,11447368 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02155091 0,11420992 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02155091 0,11394737 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02155091 0,11368602 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02155091 0,11342587 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02155091 0,1131669 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02155091 0,11290912 ! glial cell migration GO:0008347 10 5 0,000 0,02155091 0,11265251 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02155091 0,11239706 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02155091 0,11214277 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02155091 0,11188963 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02155091 0,11163762 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02155091 0,11138675 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02155091 0,111137 ! neural plate development GO:0001840 6 5 0,000 0,02155091 0,11088838 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02155091 0,11064086 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02155091 0,11039444 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02155091 0,11014912 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02155091 0,10990489 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02155091 0,10966173 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02155091 0,10941966 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02155091 0,10917864 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02155091 0,10893869 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02155091 0,10869979 ! spindle assembly GO:0051225 5 5 0,000 0,02155091 0,10846193 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02155091 0,10822512 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02155091 0,10798933 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02155091 0,10775457 ! organ regeneration GO:0031100 7 5 0,000 0,02155091 0,10752083 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02155091 0,1072881 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02155091 0,10705638 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02155091 0,10682566 GO:0055081|anion homeostasis, ! regulation of bone remodeling GO:0046850 90 53 1,000 0,02227726 0,11018861 ! cell projection assembly GO:0030031 76 53 1,000 0,02227726 0,10995216 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,02306985 0,11362024 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,02306985 0,11337746 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,02306985 0,11313572 ! mesoderm development GO:0007498 76 55 1,000 0,02387396 0,11683001 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,02551631 0,12460192 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,02551631 0,12433794 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,02551631 0,12407506 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02580577 0,12521788 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02580577 0,12495426 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02580577 0,12469175 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02580577 0,12443034 ! regulation of helicase activity GO:0051095 11 6 0,000 0,02580577 0,12417003 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02580577 0,1239108 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02580577 0,12365265 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02580577 0,12339558 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02580577 0,12313957 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02580577 0,12288463 ! prostate gland development GO:0030850 9 6 0,000 0,02580577 0,12263073 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02580577 0,12237789 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02580577 0,12212608 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02580577 0,12187531 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02580577 0,12162556 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02580577 0,12137684 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02580577 0,12112913 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02580577 0,12088243 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02580577 0,12063674 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02580577 0,12039204 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02580577 0,12014833 ! neuron adhesion GO:0007158 9 6 0,000 0,02580577 0,1199056 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02580577 0,11966386 ! signal peptide processing GO:0006465 8 6 0,000 0,02580577 0,11942309 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02580577 0,11918328 ! mRNA stabilization GO:0048255 15 6 0,000 0,02580577 0,11894444 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02580577 0,11870655 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02580577 0,11846961 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02580577 0,11823361 ! opsonization GO:0008228 8 6 0,000 0,02580577 0,11799856 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02580577 0,11776443 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02580577 0,11753124 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02580577 0,11729896 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02580577 0,1170676 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02580577 0,11683715 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02580577 0,11660761 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02580577 0,11637897 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02580577 0,11615122 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02580577 0,11592436 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02580577 0,11569839 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02580577 0,1154733 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02580577 0,11524908 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02580577 0,11502573 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02580577 0,11480324 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02580577 0,11458161 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02580577 0,11436084 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02580577 0,11414091 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02580577 0,11392183 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02580577 0,11370359 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02580577 0,11348618 ! thymic T cell selection GO:0045061 12 6 0,000 0,02580577 0,11326961 ! protein lipoylation GO:0009249 10 6 0,000 0,02580577 0,11305386 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02580577 0,11283892 ! pigment granule organization GO:0048753 11 6 0,000 0,02580577 0,11262481 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02580577 0,1124115 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,02580577 0,11219901 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02580577 0,11198731 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02580577 0,11177641 ! histidine metabolic process GO:0006547 6 6 0,000 0,02580577 0,11156631 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02580577 0,11135699 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02580577 0,11114845 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,02580577 0,1109407 ! adenohypophysis development GO:0021984 10 6 0,000 0,02580577 0,11073372 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02580577 0,11052751 ! hyperosmotic response GO:0006972 8 6 0,000 0,02580577 0,11032207 ! microtubule nucleation GO:0007020 10 6 0,000 0,02580577 0,11011739 ! ER overload response GO:0006983 7 6 0,000 0,02580577 0,10991347 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02580577 0,1097103 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02580577 0,10950789 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02580577 0,10930621 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02580577 0,10910528 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02580577 0,10890509 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02580577 0,10870563 ! response to dietary excess GO:0002021 7 6 0,000 0,02580577 0,1085069 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02580577 0,10830889 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02580577 0,10811161 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02580577 0,10791504 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02580577 0,10771919 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02580577 0,10752405 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02580577 0,10732961 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02580577 0,10713587 ! neuron apoptosis GO:0051402 8 6 0,000 0,02580577 0,10694284 ! organic alcohol transport GO:0015850 9 6 0,000 0,02580577 0,10675049 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02580577 0,10655884 ! male sex determination GO:0030238 9 6 0,000 0,02580577 0,10636788 ! carnitine transport GO:0015879 8 6 0,000 0,02580577 0,10617759 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02580577 0,10598799 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02580577 0,10579906 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02580577 0,10561081 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02580577 0,10542322 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02580577 0,1052363 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02580577 0,10505004 ! parturition GO:0007567 12 6 0,000 0,02580577 0,10486444 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02580577 0,1046795 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02580577 0,1044952 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02580577 0,10431155 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02580577 0,10412855 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02580577 0,10394619 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02580577 0,10376447 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02580577 0,10358338 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02580577 0,10340292 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02580577 0,10322309 ! macrophage differentiation GO:0030225 10 6 0,000 0,02580577 0,10304388 ! astrocyte development GO:0014002 14 6 0,000 0,02580577 0,10286529 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02580577 0,10268733 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02580577 0,10250997 ! interaction with symbiont GO:0051702 8 6 0,000 0,02580577 0,10233323 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02580577 0,1021571 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02580577 0,10198157 ! eating behavior GO:0042755 6 6 0,000 0,02580577 0,10180665 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02580577 0,10163232 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02580577 0,10145859 ! response to copper ion GO:0046688 9 6 0,000 0,02580577 0,10128545 ! DNA topological change GO:0006265 8 6 0,000 0,02580577 0,1011129 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02580577 0,10094094 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02580577 0,10076957 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02580577 0,10059877 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02580577 0,10042855 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02580577 0,10025891 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02580577 0,10008984 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02580577 0,09992134 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02580577 0,0997534 ! hair follicle maturation GO:0048820 7 6 0,000 0,02580577 0,09958603 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02580577 0,09941922 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02580577 0,09925297 ! Schwann cell development GO:0014044 14 6 0,000 0,02580577 0,09908727 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02580577 0,09892212 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02580577 0,09875753 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02580577 0,09859348 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02580577 0,09842997 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02580577 0,09826701 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02580577 0,09810459 ! histone ubiquitination GO:0016574 7 6 0,000 0,02580577 0,0979427 ! regulation of meiosis GO:0040020 10 6 0,000 0,02580577 0,09778134 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02580577 0,09762052 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02580577 0,09746022 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02580577 0,09730045 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02580577 0,0971412 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02580577 0,09698247 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02580577 0,09682426 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02580577 0,09666657 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02580577 0,09650939 ! receptor internalization GO:0031623 9 6 0,000 0,02580577 0,09635272 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02580577 0,09619655 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02580577 0,0960409 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02580577 0,09588574 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02580577 0,09573109 ! protein deubiquitination GO:0016579 8 6 0,000 0,02580577 0,09557693 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02580577 0,09542327 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,02580577 0,0952701 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02580577 0,09511743 ! axonal fasciculation GO:0007413 9 6 0,000 0,02580577 0,09496524 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02580577 0,09481354 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02580577 0,09466232 ! midbrain development GO:0030901 6 6 0,000 0,02580577 0,09451158 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02580577 0,09436133 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02580577 0,09421155 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02580577 0,09406224 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02580577 0,09391341 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02580577 0,09376505 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02580577 0,09361715 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02580577 0,09346972 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02580577 0,09332276 ! adult feeding behavior GO:0008343 6 6 0,000 0,02580577 0,09317625 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02580577 0,09303021 ! blastocyst growth GO:0001832 15 6 0,000 0,02580577 0,09288462 ! pigment granule transport GO:0051904 12 6 0,000 0,02580577 0,09273949 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02580577 0,09259481 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02580577 0,09245058 ! catecholamine transport GO:0051937 7 6 0,000 0,02580577 0,0923068 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02580577 0,09216347 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02580577 0,09202058 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02580577 0,09187813 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02580577 0,09173613 ! protein prenylation GO:0018342 10 6 0,000 0,02580577 0,09159456 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02580577 0,09145343 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02580577 0,09131273 ! viral reproductive process GO:0022415 87 58 1,000 0,02635432 0,09311051 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,02635432 0,0929677 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,02720342 0,09581602 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,02720342 0,09566952 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,02893442 0,10160176 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03004237 0,10533147 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03004237 0,10517115 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03004237 0,10501132 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03004237 0,10485197 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03004237 0,1046931 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03004237 0,10453471 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03004237 0,10437681 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03004237 0,10421938 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03004237 0,10406242 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03004237 0,10390593 ! reproductive behavior GO:0019098 12 7 0,000 0,03004237 0,10374992 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03004237 0,10359437 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,03004237 0,10343929 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03004237 0,10328467 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03004237 0,10313052 ! oligopeptide transport GO:0006857 11 7 0,000 0,03004237 0,10297682 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03004237 0,10282358 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03004237 0,1026708 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03004237 0,10251847 ! RNA methylation GO:0001510 11 7 0,000 0,03004237 0,10236659 ! pericardium development GO:0060039 8 7 0,000 0,03004237 0,10221516 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03004237 0,10206417 ! fibril organization GO:0043206 13 7 0,000 0,03004237 0,10191364 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03004237 0,10176354 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03004237 0,10161389 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,03004237 0,10146468 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03004237 0,1013159 ! lipoprotein transport GO:0042953 9 7 0,000 0,03004237 0,10116756 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03004237 0,10101966 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03004237 0,10087218 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03004237 0,10072514 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03004237 0,10057852 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03004237 0,10043233 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03004237 0,10028657 ! chemosensory behavior GO:0007635 9 7 0,000 0,03004237 0,10014123 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03004237 0,0999963 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,03004237 0,0998518 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03004237 0,09970771 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03004237 0,09956404 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03004237 0,09942079 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03004237 0,09927794 ! reflex GO:0060004 12 7 0,000 0,03004237 0,0991355 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03004237 0,09899348 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03004237 0,09885185 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03004237 0,09871064 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03004237 0,09856982 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03004237 0,09842941 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03004237 0,0982894 ! spinal cord patterning GO:0021511 7 7 0,000 0,03004237 0,09814978 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03004237 0,09801056 ! adrenal gland development GO:0030325 17 7 0,000 0,03004237 0,09787174 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03004237 0,0977333 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03004237 0,09759526 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03004237 0,09745761 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03004237 0,09732035 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03004237 0,09718347 ! endosome organization GO:0007032 10 7 0,000 0,03004237 0,09704698 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03004237 0,09691086 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03004237 0,09677514 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03004237 0,09663979 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03004237 0,09650481 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03004237 0,09637022 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03004237 0,096236 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03004237 0,09610215 ! galactose metabolic process GO:0006012 10 7 0,000 0,03004237 0,09596868 ! vesicle fusion GO:0006906 15 7 0,000 0,03004237 0,09583557 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03004237 0,09570283 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03004237 0,09557047 ! organ growth GO:0035265 11 7 0,000 0,03004237 0,09543846 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03004237 0,09530682 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,03004237 0,09517555 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03004237 0,09504463 ! retinol metabolic process GO:0042572 9 7 0,000 0,03004237 0,09491407 ! behavioral fear response GO:0001662 13 7 0,000 0,03004237 0,09478388 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03004237 0,09465404 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03004237 0,09452455 ! rRNA modification GO:0000154 12 7 0,000 0,03004237 0,09439542 ! protein heterooligomerization GO:0051291 10 7 0,000 0,03004237 0,09426664 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03004237 0,09413821 ! response to UV-B GO:0010224 11 7 0,000 0,03004237 0,09401013 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03004237 0,0938824 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03004237 0,09375502 ! intermediate filament organization GO:0045109 11 7 0,000 0,03004237 0,09362798 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03004237 0,09350128 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03004237 0,09337493 ! fibrinolysis GO:0042730 9 7 0,000 0,03004237 0,09324892 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03004237 0,09312324 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03004237 0,09299791 ! B cell lineage commitment GO:0002326 17 7 0,000 0,03004237 0,09287291 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03004237 0,09274825 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03004237 0,09262392 ! response to tropane GO:0014073 13 7 0,000 0,03004237 0,09249993 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03004237 0,09237627 ! melanosome localization GO:0032400 10 7 0,000 0,03004237 0,09225293 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03004237 0,09212993 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03004237 0,09200725 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03004237 0,0918849 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03004237 0,09176288 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03004237 0,09164118 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03004237 0,0915198 ! mast cell activation GO:0045576 9 7 0,000 0,03004237 0,09139874 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03004237 0,091278 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03004237 0,09115758 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03004237 0,09103748 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03004237 0,09091769 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03004237 0,09079822 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03004237 0,09067906 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03004237 0,09056022 ! T cell lineage commitment GO:0002360 12 7 0,000 0,03004237 0,09044168 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03004237 0,09032346 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03004237 0,09020554 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03004237 0,09008794 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03004237 0,08997063 ! response to tumor cell GO:0002347 12 7 0,000 0,03004237 0,08985364 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03004237 0,08973694 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03004237 0,08962055 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03004237 0,08950446 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03004237 0,08938868 ! diuresis GO:0030146 12 7 0,000 0,03004237 0,08927319 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03004237 0,089158 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03004237 0,0890431 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03004237 0,0889285 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03004237 0,0888142 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03004237 0,08870019 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03004237 0,08858647 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03004237 0,08847304 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03004237 0,08835991 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03004237 0,08824706 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03004237 0,0881345 ! lymph node development GO:0048535 9 7 0,000 0,03004237 0,08802222 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03004237 0,08791024 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03004237 0,08779853 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03004237 0,08768711 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03004237 0,08757598 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03004237 0,08746512 ! ATP catabolic process GO:0006200 10 7 0,000 0,03004237 0,08735455 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03004237 0,08724425 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03004237 0,08713423 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03004237 0,08702449 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03004237 0,08691503 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03004237 0,08680584 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03004237 0,08669692 ! muscle adaptation GO:0043500 12 7 0,000 0,03004237 0,08658828 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03004237 0,08647991 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03004237 0,08637181 ! retina homeostasis GO:0001895 9 7 0,000 0,03004237 0,08626398 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03004237 0,08615642 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03004237 0,08604912 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03004237 0,0859421 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03004237 0,08583534 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03004237 0,08572884 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03004237 0,08562261 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03004237 0,08551664 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,03070843 0,08730456 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,03070843 0,08719678 ! viral reproduction GO:0016032 92 63 1,000 0,03070843 0,08708926 ! regulation of lipase activity GO:0060191 109 63 1,000 0,03070843 0,08698201 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,0316113 0,08942927 ! regulation of caspase activity GO:0043281 97 65 1,000 0,03252461 0,0919 ! B cell activation GO:0042113 104 65 1,000 0,03252461 0,09178724 ! defense response to bacterium GO:0042742 73 65 1,000 0,03252461 0,09167475 ! protein oligomerization GO:0051259 100 65 1,000 0,03252461 0,09156255 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,03344824 0,09404763 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,03344824 0,0939328 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03426078 0,09609731 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03426078 0,09598027 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,03426078 0,0958635 ! axon extension GO:0048675 11 8 0,000 0,03426078 0,09574702 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03426078 0,09563082 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03426078 0,09551491 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03426078 0,09539927 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03426078 0,09528392 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03426078 0,09516884 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03426078 0,09505404 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,03426078 0,09493952 ! phosphate transport GO:0006817 10 8 0,000 0,03426078 0,09482527 ! N-glycan processing GO:0006491 12 8 0,000 0,03426078 0,0947113 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03426078 0,0945976 ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03426078 0,09448417 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03426078 0,09437102 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03426078 0,09425813 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03426078 0,09414552 ! succinate metabolic process GO:0006105 14 8 0,000 0,03426078 0,09403317 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03426078 0,09392109 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03426078 0,09380928 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03426078 0,09369774 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03426078 0,09358646 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03426078 0,09347544 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03426078 0,09336469 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03426078 0,0932542 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03426078 0,09314397 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03426078 0,093034 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03426078 0,09292429 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03426078 0,09281484 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03426078 0,09270564 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03426078 0,09259671 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03426078 0,09248803 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03426078 0,0923796 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,03426078 0,09227143 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03426078 0,09216351 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03426078 0,09205584 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03426078 0,09194842 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03426078 0,09184126 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03426078 0,09173434 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03426078 0,09162767 ! melanin metabolic process GO:0006582 12 8 0,000 0,03426078 0,09152125 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03426078 0,09141508 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03426078 0,09130915 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03426078 0,09120347 ! macrophage activation GO:0042116 12 8 0,000 0,03426078 0,09109803 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03426078 0,09099284 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03426078 0,09088789 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03426078 0,09078318 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03426078 0,09067871 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03426078 0,09057448 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03426078 0,09047049 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03426078 0,09036674 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03426078 0,09026323 ! ruffle organization GO:0031529 11 8 0,000 0,03426078 0,09015995 ! osteoblast development GO:0002076 13 8 0,000 0,03426078 0,09005691 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03426078 0,08995411 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03426078 0,08985154 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03426078 0,0897492 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03426078 0,0896471 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03426078 0,08954523 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03426078 0,08944358 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03426078 0,08934217 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03426078 0,08924099 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03426078 0,08914004 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03426078 0,08903932 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03426078 0,08893882 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03426078 0,08883855 ! segment specification GO:0007379 10 8 0,000 0,03426078 0,08873851 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03426078 0,08863869 ! cellular extravasation GO:0045123 11 8 0,000 0,03426078 0,0885391 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03426078 0,08843973 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03426078 0,08834058 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03426078 0,08824166 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03426078 0,08814295 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03426078 0,08804447 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 0,03426078 0,0879462 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03426078 0,08784816 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03426078 0,08775033 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03426078 0,08765272 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03426078 0,08755533 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03426078 0,08745816 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03426078 0,0873612 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03426078 0,08726445 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03426078 0,08716792 ! icosanoid secretion GO:0032309 12 8 0,000 0,03426078 0,0870716 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03426078 0,08697549 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03426078 0,0868796 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03426078 0,08678392 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03426078 0,08668845 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03426078 0,08659318 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03426078 0,08649813 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03426078 0,08640329 ! sterol catabolic process GO:0016127 9 8 0,000 0,03426078 0,08630865 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03426078 0,08621422 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03426078 0,08612 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03426078 0,08602598 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03426078 0,08593217 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03426078 0,08583856 ! prophase GO:0051324 11 8 0,000 0,03426078 0,08574516 ! S phase GO:0051320 8 8 0,000 0,03426078 0,08565195 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03426078 0,08555896 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03426078 0,08546616 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03426078 0,08537356 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03426078 0,08528117 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03426078 0,08518897 ! hormone catabolic process GO:0042447 13 8 0,000 0,03426078 0,08509697 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03426078 0,08500518 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03426078 0,08491358 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03426078 0,08482217 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03426078 0,08473097 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03426078 0,08463995 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03426078 0,08454914 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03426078 0,08445852 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03426078 0,08436809 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03426078 0,08427786 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03426078 0,08418782 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03426078 0,08409797 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03426078 0,08400831 ! regulation of embryonic development GO:0045995 16 8 0,000 0,03426078 0,08391885 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03426078 0,08382957 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03426078 0,08374049 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,0343821 0,08394781 ! inorganic anion transport GO:0015698 93 68 1,000 0,03532609 0,08616118 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,037244 0,0907428 ! humoral immune response GO:0006959 86 70 1,000 0,037244 0,09064677 ! eye development GO:0001654 111 70 1,000 0,037244 0,09055095 ! regulation of catabolic process GO:0009894 106 70 1,000 0,037244 0,09045533 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,03821773 0,09272234 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03846109 0,09321444 ! regulation of developmental growth GO:0048638 13 9 0,000 0,03846109 0,09311632 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03846109 0,09301841 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03846109 0,0929207 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03846109 0,0928232 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03846109 0,0927259 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03846109 0,0926288 GO:0010469|regulation of receptor activity, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03846109 0,09253191 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03846109 0,09243522 ! social behavior GO:0035176 14 9 0,000 0,03846109 0,09233873 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03846109 0,09224245 ! artery development GO:0060840 19 9 0,000 0,03846109 0,09214636 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03846109 0,09205047 ! response to pain GO:0048265 16 9 0,000 0,03846109 0,09195479 ! protein complex disassembly GO:0043241 17 9 0,000 0,03846109 0,0918593 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03846109 0,09176401 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03846109 0,09166892 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03846109 0,09157402 ! lung alveolus development GO:0048286 17 9 0,000 0,03846109 0,09147932 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03846109 0,09138482 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03846109 0,09129051 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03846109 0,0911964 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03846109 0,09110248 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03846109 0,09100875 ! protein targeting to ER GO:0045047 19 9 0,000 0,03846109 0,09091522 ! T cell selection GO:0045058 18 9 0,000 0,03846109 0,09082187 ! endoderm development GO:0007492 12 9 0,000 0,03846109 0,09072872 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03846109 0,09063576 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03846109 0,090543 ! arginine catabolic process GO:0006527 10 9 0,000 0,03846109 0,09045042 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03846109 0,09035802 ! L-serine metabolic process GO:0006563 13 9 0,000 0,03846109 0,09026582 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03846109 0,09017381 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03846109 0,09008198 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03846109 0,08999034 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03846109 0,08989889 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03846109 0,08980762 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03846109 0,08971654 ! mannose metabolic process GO:0006013 9 9 0,000 0,03846109 0,08962564 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03846109 0,08953493 ! receptor clustering GO:0043113 15 9 0,000 0,03846109 0,08944439 ! epithelial cell development GO:0002064 10 9 0,000 0,03846109 0,08935405 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03846109 0,08926388 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03846109 0,0891739 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03846109 0,08908409 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03846109 0,08899447 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03846109 0,08890503 ! motor axon guidance GO:0008045 14 9 0,000 0,03846109 0,08881577 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03846109 0,08872669 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03846109 0,08863778 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03846109 0,08854906 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03846109 0,08846051 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03846109 0,08837213 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03846109 0,08828394 ! DNA ligation GO:0006266 14 9 0,000 0,03846109 0,08819592 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03846109 0,08810807 ! response to amine stimulus GO:0014075 13 9 0,000 0,03846109 0,0880204 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03846109 0,08793291 ! erythrocyte development GO:0048821 11 9 0,000 0,03846109 0,08784559 ! renal water homeostasis GO:0003091 14 9 0,000 0,03846109 0,08775844 ! postreplication repair GO:0006301 11 9 0,000 0,03846109 0,08767146 ! mRNA cleavage GO:0006379 13 9 0,000 0,03846109 0,08758466 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03846109 0,08749803 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03846109 0,08741157 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03846109 0,08732528 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03846109 0,08723916 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03846109 0,08715321 ! acid secretion GO:0046717 14 9 0,000 0,03846109 0,08706743 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03846109 0,08698182 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03846109 0,08689637 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03846109 0,0868111 ! purine base metabolic process GO:0006144 18 9 0,000 0,03846109 0,08672599 ! oocyte differentiation GO:0009994 12 9 0,000 0,03846109 0,08664104 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,03846109 0,08655627 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03846109 0,08647166 ! spleen development GO:0048536 15 9 0,000 0,03846109 0,08638721 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03846109 0,08630293 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03846109 0,08621882 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03846109 0,08613486 ! detection of calcium ion GO:0005513 13 9 0,000 0,03846109 0,08605108 ! blastocyst formation GO:0001825 12 9 0,000 0,03846109 0,08596745 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03846109 0,08588399 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03846109 0,08580069 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03846109 0,08571754 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03846109 0,08563457 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03846109 0,08555175 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03846109 0,08546909 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03846109 0,08538659 ! prepulse inhibition GO:0060134 14 9 0,000 0,03846109 0,08530425 ! insulin secretion GO:0030073 17 9 0,000 0,03846109 0,08522207 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03846109 0,08514004 ! response to nicotine GO:0035094 16 9 0,000 0,03846109 0,08505818 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03846109 0,08497647 ! nucleus localization GO:0051647 15 9 0,000 0,03846109 0,08489492 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03846109 0,08481352 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,03920117 0,08636273 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,03920117 0,08628009 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,04019423 0,08838118 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,04019423 0,08829677 ! protein import into nucleus GO:0006606 118 74 1,000 0,04119679 0,09041281 ! negative regulation of growth GO:0045926 123 75 1,000 0,04220877 0,09254545 ! nuclear import GO:0051170 121 75 1,000 0,04220877 0,09245731 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04264337 0,09332041 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04264337 0,0932317 ! neuron fate specification GO:0048665 11 10 0,000 0,04264337 0,09314316 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04264337 0,09305479 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04264337 0,09296659 ! thyroid gland development GO:0030878 19 10 0,000 0,04264337 0,09287855 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,04264337 0,09279068 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04264337 0,09270297 ! synapsis GO:0007129 13 10 0,000 0,04264337 0,09261544 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04264337 0,09252806 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04264337 0,09244086 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04264337 0,09235381 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04264337 0,09226693 ! sulfate transport GO:0008272 12 10 0,000 0,04264337 0,09218021 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04264337 0,09209366 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,04264337 0,09200727 ! androgen metabolic process GO:0008209 13 10 0,000 0,04264337 0,09192104 ! phospholipid efflux GO:0033700 16 10 0,000 0,04264337 0,09183497 ! hippocampus development GO:0021766 19 10 0,000 0,04264337 0,09174906 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04264337 0,09166332 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04264337 0,09157773 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04264337 0,0914923 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04264337 0,09140703 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04264337 0,09132193 ! pathogenesis GO:0009405 13 10 0,000 0,04264337 0,09123697 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04264337 0,09115218 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04264337 0,09106755 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04264337 0,09098307 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04264337 0,09089875 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04264337 0,09081458 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04264337 0,09073057 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04264337 0,09064672 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04264337 0,09056302 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04264337 0,09047947 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04264337 0,09039608 ! response to X-ray GO:0010165 16 10 0,000 0,04264337 0,09031284 ! B cell proliferation GO:0042100 14 10 0,000 0,04264337 0,09022976 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04264337 0,09014683 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04264337 0,09006405 ! forebrain cell migration GO:0021885 17 10 0,000 0,04264337 0,08998142 ! lipid digestion GO:0044241 15 10 0,000 0,04264337 0,08989894 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04264337 0,08981662 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04264337 0,08973444 ! UV protection GO:0009650 14 10 0,000 0,04264337 0,08965242 ! entry into host cell GO:0030260 20 10 0,000 0,04264337 0,08957055 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04264337 0,08948882 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04264337 0,08940724 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04264337 0,08932582 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,04264337 0,08924454 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04264337 0,08916341 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04264337 0,08908242 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04264337 0,08900159 ! regulation of organ growth GO:0046620 11 10 0,000 0,04264337 0,0889209 ! response to dsRNA GO:0043331 18 10 0,000 0,04264337 0,08884035 ! embryonic axis specification GO:0000578 12 10 0,000 0,04264337 0,08875995 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04264337 0,0886797 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04264337 0,08859959 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04264337 0,08851963 ! cranial nerve development GO:0021545 12 10 0,000 0,04264337 0,08843981 ! fucose catabolic process GO:0019317 16 10 0,000 0,04264337 0,08836013 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,04264337 0,0882806 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04264337 0,08820121 ! protein sumoylation GO:0016925 12 10 0,000 0,04264337 0,08812197 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04264337 0,08804286 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04264337 0,0879639 ! zymogen activation GO:0031638 14 10 0,000 0,04264337 0,08788508 ! salivary gland development GO:0007431 22 10 0,000 0,04264337 0,0878064 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04264337 0,08772786 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04264337 0,08764946 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04264337 0,0875712 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04264337 0,08749308 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04264337 0,0874151 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04264337 0,08733726 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04264337 0,08725956 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04264337 0,087182 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04264337 0,08710457 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04264337 0,08702728 ! embryonic gut development GO:0048566 11 10 0,000 0,04264337 0,08695013 ! activation of innate immune response GO:0002218 10 10 0,000 0,04264337 0,08687312 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04264337 0,08679624 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04264337 0,08671949 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04264337 0,08664289 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04264337 0,08656641 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04264337 0,08649008 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04264337 0,08641387 ! tRNA metabolic process GO:0006399 95 76 1,000 0,04323007 0,08752566 ! regulation of protein transport GO:0051223 114 76 1,000 0,04323007 0,08744869 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 148 77 1,000 0,04426058 0,0894546 ! respiratory burst GO:0045730 14 11 0,000 0,04680769 0,09451949 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04680769 0,09443658 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04680769 0,09435381 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04680769 0,09427119 ! virus-host interaction GO:0019048 17 11 0,000 0,04680769 0,09418871 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,04680769 0,09410638 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,04680769 0,09402419 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04680769 0,09394214 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04680769 0,09386024 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,04680769 0,09377848 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04680769 0,09369686 ! mating GO:0007618 14 11 0,000 0,04680769 0,09361539 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,04680769 0,09353405 ! T cell proliferation GO:0042098 20 11 0,000 0,04680769 0,09345286 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04680769 0,09337181 ! bone resorption GO:0045453 16 11 0,000 0,04680769 0,0932909 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04680769 0,09321013 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04680769 0,0931295 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04680769 0,093049 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04680769 0,09296865 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04680769 0,09288844 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04680769 0,09280836 ! syncytium formation GO:0006949 15 11 0,000 0,04680769 0,09272842 ! plasma membrane organization GO:0007009 18 11 0,000 0,04680769 0,09264862 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04680769 0,09256896 ! focal adhesion formation GO:0048041 24 11 0,000 0,04680769 0,09248943 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04680769 0,09241004 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04680769 0,09233079 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,04680769 0,09225167 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04680769 0,09217269 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04680769 0,09209384 ! adult heart development GO:0007512 11 11 0,000 0,04680769 0,09201513 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04680769 0,09193655 ! temperature homeostasis GO:0001659 16 11 0,000 0,04680769 0,0918581 ! L-glutamate transport GO:0015813 16 11 0,000 0,04680769 0,09177979 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04680769 0,09170162 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04680769 0,09162357 ! protein homotetramerization GO:0051289 18 11 0,000 0,04680769 0,09154566 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04680769 0,09146788 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04680769 0,09139024 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04680769 0,09131272 ! vasoconstriction GO:0042310 15 11 0,000 0,04680769 0,09123534 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04680769 0,09115808 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04680769 0,09108096 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04680769 0,09100397 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04680769 0,09092711 ! ribosome assembly GO:0042255 13 11 0,000 0,04680769 0,09085038 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04680769 0,09077378 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04680769 0,0906973 ! chromatin silencing GO:0006342 19 11 0,000 0,04680769 0,09062096 ! nucleosome positioning GO:0016584 13 11 0,000 0,04680769 0,09054474 ! T cell homeostasis GO:0043029 20 11 0,000 0,04680769 0,09046865 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04680769 0,09039269 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04680769 0,09031686 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04680769 0,09024115 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04680769 0,09016558 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04680769 0,09009012 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04680769 0,0900148 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04680769 0,0899396 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04680769 0,08986452 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04680769 0,08978957 ! male genitalia development GO:0030539 13 11 0,000 0,04680769 0,08971475 ! cholesterol efflux GO:0033344 19 11 0,000 0,04680769 0,08964005 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04680769 0,08956547 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04680769 0,08949102 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04680769 0,08941669 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04680769 0,08934249 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04680769 0,08926841 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04680769 0,08919445 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,04680769 0,08912061 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,04680769 0,0890469 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04680769 0,0889733 ! lysogeny GO:0030069 18 11 0,000 0,04680769 0,08889983 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04680769 0,08882648 ! acrosome reaction GO:0007340 13 11 0,000 0,04680769 0,08875325 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04680769 0,08868015 ! protein localization in nucleus GO:0034504 133 80 1,000 0,04740646 0,08974062 ! regulation of neurological system process GO:0031644 122 81 1,000 0,04847287 0,09168389 ! ossification GO:0001503 134 82 1,000 0,04954803 0,09364049 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,05063183 0,09561019 ! reproductive cellular process GO:0048610 14 12 0,000 0,05095414 0,09613989 ! tRNA modification GO:0006400 14 12 0,000 0,05095414 0,09606109 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05095414 0,09598242 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05095414 0,09590387 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05095414 0,09582545 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05095414 0,09574717 ! non-recombinational repair GO:0000726 19 12 0,000 0,05095414 0,095669 GO:0006303|double-strand break repair via nonhomologous end joining, ! peroxisomal transport GO:0043574 21 12 0,000 0,05095414 0,09559097 ! cartilage condensation GO:0001502 18 12 0,000 0,05095414 0,09551306 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05095414 0,09543529 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05095414 0,09535763 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05095414 0,09528011 ! palate development GO:0060021 15 12 0,000 0,05095414 0,09520271 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,05095414 0,09512543 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05095414 0,09504828 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05095414 0,09497126 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05095414 0,09489436 ! arginine metabolic process GO:0006525 13 12 0,000 0,05095414 0,09481758 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05095414 0,09474093 ! methionine metabolic process GO:0006555 13 12 0,000 0,05095414 0,0946644 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05095414 0,094588 ! Golgi organization GO:0007030 18 12 0,000 0,05095414 0,09451172 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05095414 0,09443556 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05095414 0,09435953 ! monoamine transport GO:0015844 13 12 0,000 0,05095414 0,09428361 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05095414 0,09420782 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05095414 0,09413215 ! L-amino acid transport GO:0015807 20 12 0,000 0,05095414 0,09405661 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05095414 0,09398118 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05095414 0,09390587 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05095414 0,09383069 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05095414 0,09375562 ! cerebellum development GO:0021549 13 12 0,000 0,05095414 0,09368068 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05095414 0,09360586 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05095414 0,09353115 ! histone methylation GO:0016571 15 12 0,000 0,05095414 0,09345656 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05095414 0,0933821 ! gland morphogenesis GO:0022612 23 12 0,000 0,05095414 0,09330775 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05095414 0,09323352 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05095414 0,0931594 ! response to gamma radiation GO:0010332 20 12 0,000 0,05095414 0,09308541 ! intestinal absorption GO:0050892 19 12 0,000 0,05095414 0,09301153 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05095414 0,09293777 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05095414 0,09286413 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,05095414 0,0927906 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05095414 0,09271719 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,05095414 0,0926439 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05095414 0,09257072 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05095414 0,09249766 ! microspike assembly GO:0030035 23 12 0,000 0,05095414 0,09242471 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05095414 0,09235188 ! response to cold GO:0009409 14 12 0,000 0,05095414 0,09227916 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,052825 0,09559205 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,052825 0,0955169 ! regulation of protein localization GO:0032880 132 85 1,000 0,052825 0,09544186 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,05505163 0,09938677 GO:0060538|skeletal muscle organ development, ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05508279 0,09936504 ! water transport GO:0006833 17 13 0,000 0,05508279 0,09928716 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05508279 0,09920941 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05508279 0,09913179 ! lipid localization GO:0010876 24 13 0,000 0,05508279 0,09905428 GO:0019915|lipid storage, ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,05508279 0,09897689 ! organelle fusion GO:0048284 28 13 0,000 0,05508279 0,09889963 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05508279 0,09882248 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,05508279 0,09874546 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,05508279 0,09866855 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05508279 0,09859177 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05508279 0,0985151 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05508279 0,09843856 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05508279 0,09836213 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05508279 0,09828582 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05508279 0,09820963 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05508279 0,09813356 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05508279 0,0980576 ! NAD metabolic process GO:0019674 21 13 0,000 0,05508279 0,09798176 ! exocrine system development GO:0035272 27 13 0,000 0,05508279 0,09790604 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,05508279 0,09783044 ! bone mineralization GO:0030282 15 13 0,000 0,05508279 0,09775495 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05508279 0,09767958 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,05508279 0,09760433 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05508279 0,09752919 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05508279 0,09745417 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05508279 0,09737926 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,05508279 0,09730447 ! genitalia development GO:0048806 15 13 0,000 0,05508279 0,09722979 ! regulation of cellular pH GO:0030641 20 13 0,000 0,05508279 0,09715523 ! cellular pigmentation GO:0033059 24 13 0,000 0,05508279 0,09708078 ! tissue regeneration GO:0042246 21 13 0,000 0,05508279 0,09700645 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,05508279 0,09693223 ! cofactor transport GO:0051181 19 13 0,000 0,05508279 0,09685812 ! NADP metabolic process GO:0006739 18 13 0,000 0,05508279 0,09678413 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05508279 0,09671025 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05508279 0,09663648 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05508279 0,09656282 ! gas transport GO:0015669 18 13 0,000 0,05508279 0,09648928 ! regulation of RNA stability GO:0043487 28 13 0,000 0,05508279 0,09641585 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05508279 0,09634253 ! regulation of axon extension GO:0030516 23 13 0,000 0,05508279 0,09626932 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05508279 0,09619622 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,05508279 0,09612323 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05508279 0,09605036 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05508279 0,09597759 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,05508279 0,09590494 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05508279 0,09583239 ! leukocyte differentiation GO:0002521 143 90 1,000 0,05845274 0,10161851 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05919371 0,10282896 ! superoxide anion generation GO:0042554 18 14 0,000 0,05919371 0,10275135 ! neuron maturation GO:0042551 21 14 0,000 0,05919371 0,10267386 ! regulation of S phase GO:0033261 18 14 0,000 0,05919371 0,10259649 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05919371 0,10251923 ! myotube differentiation GO:0014902 21 14 0,000 0,05919371 0,10244209 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,05919371 0,10236507 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,05919371 0,10228816 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05919371 0,10221137 ! inositol metabolic process GO:0006020 20 14 0,000 0,05919371 0,10213469 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05919371 0,10205813 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05919371 0,10198168 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05919371 0,10190535 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05919371 0,10182913 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05919371 0,10175302 ! response to cAMP GO:0051591 19 14 0,000 0,05919371 0,10167703 ! limbic system development GO:0021761 25 14 0,000 0,05919371 0,10160115 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05919371 0,10152539 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,05919371 0,10144973 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05919371 0,10137419 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05919371 0,10129877 ! glycine metabolic process GO:0006544 22 14 0,000 0,05919371 0,10122345 ! pituitary gland development GO:0021983 23 14 0,000 0,05919371 0,10114825 ! cellular response to starvation GO:0009267 21 14 0,000 0,05919371 0,10107316 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05919371 0,10099818 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,05919371 0,10092331 ! regulation of heart rate GO:0002027 23 14 0,000 0,05919371 0,10084855 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05919371 0,1007739 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05919371 0,10069937 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05919371 0,10062494 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05919371 0,10055062 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,05919371 0,10047642 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,05919371 0,10040232 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05919371 0,10032833 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,05919371 0,10025445 ! axon cargo transport GO:0008088 27 14 0,000 0,05919371 0,10018068 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05919371 0,10010702 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05919371 0,10003346 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05919371 0,09996002 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05919371 0,09988668 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05919371 0,09981345 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05919371 0,09974033 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05919371 0,09966731 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05919371 0,0995944 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05919371 0,0995216 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05919371 0,0994489 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05919371 0,09937631 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05919371 0,09930382 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05919371 0,09923145 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05919371 0,09915917 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,05919371 0,099087 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05919371 0,09901494 ! cell killing GO:0001906 20 14 0,000 0,05919371 0,09894298 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,05919371 0,09887113 ! cilium assembly GO:0042384 20 14 0,000 0,05919371 0,09879938 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05919371 0,09872773 ! response to virus GO:0009615 122 91 1,000 0,05960239 0,09933732 ! response to oxidative stress GO:0006979 141 94 1,000 0,06309797 0,10508713 ! positive regulation of cell size GO:0045793 20 15 0,000 0,06328699 0,10532567 ! metencephalon development GO:0022037 19 15 0,000 0,06328699 0,10524951 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,06328699 0,10517346 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,06328699 0,10509752 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,06328699 0,1050217 ! skin development GO:0043588 25 15 0,000 0,06328699 0,10494598 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,06328699 0,10487037 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,06328699 0,10479487 ! lipid phosphorylation GO:0046834 23 15 0,000 0,06328699 0,10471947 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,06328699 0,10464419 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,06328699 0,10456902 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,06328699 0,10449395 ! bile acid metabolic process GO:0008206 22 15 0,000 0,06328699 0,10441899 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,06328699 0,10434414 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,06328699 0,10426939 ! adult walking behavior GO:0007628 25 15 0,000 0,06328699 0,10419475 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,06328699 0,10412022 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,06328699 0,1040458 ! myoblast differentiation GO:0045445 27 15 0,000 0,06328699 0,10397148 ! centrosome cycle GO:0007098 16 15 0,000 0,06328699 0,10389727 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,06328699 0,10382316 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,06328699 0,10374916 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,06328699 0,10367526 ! cerebral cortex development GO:0021987 29 15 0,000 0,06328699 0,10360147 ! response to osmotic stress GO:0006970 22 15 0,000 0,06328699 0,10352779 ! vesicle coating GO:0006901 25 15 0,000 0,06328699 0,10345421 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,06328699 0,10338073 ! DNA integration GO:0015074 22 15 0,000 0,06328699 0,10330736 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,06328699 0,10323409 ! peptide secretion GO:0002790 27 15 0,000 0,06328699 0,10316093 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,06328699 0,10308787 ! regulation of vasodilation GO:0042312 24 15 0,000 0,06328699 0,10301491 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,06328699 0,10294206 ! neuron recognition GO:0008038 22 15 0,000 0,06328699 0,10286931 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,06328699 0,10279666 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,06328699 0,10272411 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,06328699 0,10265167 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,06328699 0,10257933 ! biomineral formation GO:0031214 18 15 0,000 0,06328699 0,10250709 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,06328699 0,10243495 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,06328699 0,10236292 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,06328699 0,10229098 ! dopamine metabolic process GO:0042417 30 15 0,000 0,06328699 0,10221915 ! organic cation transport GO:0015695 19 15 0,000 0,06328699 0,10214742 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,06328699 0,10207579 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,06328699 0,10200425 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,06328699 0,10193282 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,06328699 0,10186149 ! defense response to virus GO:0051607 27 15 0,000 0,06328699 0,10179026 ! peptide hormone processing GO:0016486 19 15 0,000 0,06328699 0,10171913 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,06328699 0,10164809 ! angiogenesis GO:0001525 149 95 1,000 0,06427841 0,10316841 ! in utero embryonic development GO:0001701 147 96 1,000 0,06546633 0,10500178 ! response to light stimulus GO:0009416 153 96 1,000 0,06546633 0,10492861 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,06666164 0,10677004 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! protein secretion GO:0009306 27 16 0,000 0,06736268 0,10781779 ! hormone secretion GO:0046879 25 16 0,000 0,06736268 0,10774282 ! bone remodeling GO:0046849 24 16 0,000 0,06736268 0,10766794 ! endothelial cell migration GO:0043542 22 16 0,000 0,06736268 0,10759317 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06736268 0,10751851 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06736268 0,10744395 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06736268 0,10736949 ! glial cell development GO:0021782 24 16 0,000 0,06736268 0,10729513 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06736268 0,10722088 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06736268 0,10714673 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06736268 0,10707268 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06736268 0,10699874 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,06736268 0,10692489 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,06736268 0,10685115 GO:0030968|endoplasmic reticulum unfolded protein response, ! fructose metabolic process GO:0006000 20 16 0,000 0,06736268 0,10677751 ! regulation of protein binding GO:0043393 27 16 0,000 0,06736268 0,10670397 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,06736268 0,10663054 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06736268 0,1065572 ! protein export from nucleus GO:0006611 24 16 0,000 0,06736268 0,10648397 ! negative regulation of immune response GO:0050777 28 16 0,000 0,06736268 0,10641083 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06736268 0,1063378 ! DNA replication initiation GO:0006270 25 16 0,000 0,06736268 0,10626486 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,06736268 0,10619203 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06736268 0,1061193 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06736268 0,10604666 ! diencephalon development GO:0021536 25 16 0,000 0,06736268 0,10597413 ! oogenesis GO:0048477 23 16 0,000 0,06736268 0,10590169 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,06736268 0,10582935 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06736268 0,10575711 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,06736268 0,10568497 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,06736268 0,10561293 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,06736268 0,10554099 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06736268 0,10546914 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06736268 0,1053974 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06736268 0,10532575 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,06736268 0,10525419 ! nerve development GO:0021675 18 16 0,000 0,06736268 0,10518274 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06736268 0,10511138 ! negative regulation of translation GO:0017148 22 16 0,000 0,06736268 0,10504012 ! protein import GO:0017038 156 99 1,000 0,06907412 0,10763583 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,06907412 0,10756295 ! regulation of translation GO:0006417 151 100 1,000 0,07029112 0,10938401 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,07029112 0,10931005 ! protein localization in organelle GO:0033365 161 100 1,000 0,07029112 0,10923619 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,07142088 0,11091696 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,07142088 0,11084212 ! negative regulation of defense response GO:0031348 19 17 0,000 0,07142088 0,11076738 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,07142088 0,11069274 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,07142088 0,1106182 ! glycerol metabolic process GO:0006071 20 17 0,000 0,07142088 0,11054376 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,07142088 0,11046942 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,07142088 0,11039517 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,07142088 0,11032103 ! signal complex assembly GO:0007172 29 17 0,000 0,07142088 0,11024699 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,07142088 0,11017305 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,07142088 0,11009921 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,07142088 0,11002547 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,07142088 0,10995182 ! memory GO:0007613 25 17 0,000 0,07142088 0,10987827 ! keratinization GO:0031424 17 17 0,000 0,07142088 0,10980483 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,07142088 0,10973148 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,07142088 0,10965822 ! retinoid metabolic process GO:0001523 22 17 0,000 0,07142088 0,10958507 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,07142088 0,10951201 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,07142088 0,10943905 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,07142088 0,10936619 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,07142088 0,10929343 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,07142088 0,10922076 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,07142088 0,10914819 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,07142088 0,10907571 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,07142088 0,10900333 ! membrane budding GO:0006900 29 17 0,000 0,07142088 0,10893105 ! heme metabolic process GO:0042168 27 17 0,000 0,07142088 0,10885886 ! actin filament bundle formation GO:0051017 26 17 0,000 0,07142088 0,10878677 ! neuromuscular junction development GO:0007528 23 17 0,000 0,07142088 0,10871477 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,07142088 0,10864287 ! body fluid secretion GO:0007589 27 17 0,000 0,07142088 0,10857106 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,07142088 0,10849935 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,07142088 0,10842774 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,07142088 0,10835621 ! sensory perception of pain GO:0019233 23 17 0,000 0,07142088 0,10828479 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,07142088 0,10821345 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,07142088 0,10814221 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,07142088 0,10807107 ! synaptogenesis GO:0007416 24 17 0,000 0,07142088 0,10800001 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,07142088 0,10792905 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,07142088 0,10785819 ! cell-cell junction organization GO:0045216 25 17 0,000 0,07142088 0,10778741 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,07142088 0,10771673 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,07142088 0,10764615 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,07142088 0,10757565 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,07142088 0,10750525 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,07142088 0,10743494 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,07142088 0,10736472 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,07546165 0,11336498 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,07546165 0,11329098 ! positive regulation of translation GO:0045727 28 18 0,000 0,07546165 0,11321708 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,07546165 0,11314328 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,07546165 0,11306957 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,07546165 0,11299595 ! cAMP metabolic process GO:0046058 33 18 0,000 0,07546165 0,11292244 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,07546165 0,11284902 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,07546165 0,11277569 ! axis specification GO:0009798 26 18 0,000 0,07546165 0,11270246 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,07546165 0,11262932 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,07546165 0,11255628 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,07546165 0,11248334 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,07546165 0,11241048 ! glutamine metabolic process GO:0006541 23 18 0,000 0,07546165 0,11233773 ! response to retinoic acid GO:0032526 25 18 0,000 0,07546165 0,11226506 ! pigmentation during development GO:0048066 31 18 0,000 0,07546165 0,11219249 ! central nervous system neuron development GO:0021954 30 18 0,000 0,07546165 0,11212002 ! fucose metabolic process GO:0006004 26 18 0,000 0,07546165 0,11204763 ! response to fungus GO:0009620 19 18 0,000 0,07546165 0,11197535 ! peptide cross-linking GO:0018149 31 18 0,000 0,07546165 0,11190315 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,07546165 0,11183105 ! heart process GO:0003015 27 18 0,000 0,07546165 0,11175904 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,07546165 0,11168712 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,07546165 0,1116153 ! visual learning GO:0008542 35 18 0,000 0,07546165 0,11154356 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,07546165 0,11147192 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,07546165 0,11140038 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,07546165 0,11132892 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,07546165 0,11125756 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,07546165 0,11118628 ! vitamin transport GO:0051180 24 18 0,000 0,07546165 0,1111151 ! hormone transport GO:0009914 27 18 0,000 0,07546165 0,11104401 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,07546165 0,11097301 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,07546165 0,1109021 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,07546165 0,11083128 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,07546165 0,11076055 ! cell-cell recognition GO:0009988 20 18 0,000 0,07546165 0,11068991 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,07546165 0,11061937 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,07546165 0,11054891 ! regulation of glucose import GO:0046324 21 18 0,000 0,07546165 0,11047854 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,07546165 0,11040826 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,07546165 0,11033807 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,07546165 0,11026797 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,07546165 0,11019796 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,07948506 0,11599977 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,07948506 0,11592621 ! positive regulation of ossification GO:0045778 30 19 0,000 0,07948506 0,11585275 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,07948506 0,11577938 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,07948506 0,1157061 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,07948506 0,11563292 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,07948506 0,11555982 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,07948506 0,11548682 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,07948506 0,11541391 ! regeneration GO:0031099 32 19 0,000 0,07948506 0,1153411 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,07948506 0,11526837 ! response to alkaloid GO:0043279 32 19 0,000 0,07948506 0,11519574 ! sensory perception of taste GO:0050909 23 19 0,000 0,07948506 0,1151232 ! smooth muscle contraction GO:0006939 36 19 0,000 0,07948506 0,11505075 ! peroxisome organization GO:0007031 29 19 0,000 0,07948506 0,11497839 ! digestive system process GO:0022600 30 19 0,000 0,07948506 0,11490612 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,07948506 0,11483394 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,07948506 0,11476186 ! response to vitamin A GO:0033189 26 19 0,000 0,07948506 0,11468986 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,07948506 0,11461796 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,07948506 0,11454614 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,07948506 0,11447441 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,07948506 0,11440278 ! response to starvation GO:0042594 30 19 0,000 0,07948506 0,11433123 ! sex determination GO:0007530 29 19 0,000 0,07948506 0,11425978 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,07948506 0,11418841 ! plasma membrane fusion GO:0045026 23 19 0,000 0,07948506 0,11411713 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,07948506 0,11404594 ! cytolysis GO:0019835 20 19 0,000 0,07948506 0,11397484 ! renal system process GO:0003014 35 19 0,000 0,07948506 0,11390383 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,07948506 0,1138329 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,07948506 0,11376207 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,07948506 0,11369132 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,07948506 0,11362066 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,07948506 0,11355009 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,07948506 0,1134796 ! sarcomere organization GO:0045214 23 19 0,000 0,07948506 0,11340921 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,07948506 0,1133389 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,07948506 0,11326867 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,07948506 0,11319854 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,07948506 0,11312849 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,07948506 0,11305853 ! protein stabilization GO:0050821 26 19 0,000 0,07948506 0,11298865 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,0834912 0,1186101 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,0834912 0,11853688 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,0834912 0,11846376 ! response to vitamin GO:0033273 29 20 0,000 0,0834912 0,11839072 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,0834912 0,11831778 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,0834912 0,11824492 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,0834912 0,11817215 ! spinal cord development GO:0021510 31 20 0,000 0,0834912 0,11809948 ! response to ethanol GO:0045471 37 20 0,000 0,0834912 0,11802689 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,0834912 0,11795439 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,0834912 0,11788198 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,0834912 0,11780966 ! chromosome condensation GO:0030261 31 20 0,000 0,0834912 0,11773743 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,0834912 0,11766529 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,0834912 0,11759323 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,0834912 0,11752127 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,0834912 0,11744939 ! pallium development GO:0021543 38 20 0,000 0,0834912 0,1173776 ! DNA modification GO:0006304 28 20 0,000 0,0834912 0,1173059 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,0834912 0,11723428 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,0834912 0,11716275 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,0834912 0,11709131 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,0834912 0,11701996 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,0834912 0,11694869 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,0834912 0,11687751 ! collagen catabolic process GO:0030574 25 20 0,000 0,0834912 0,11680642 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,0834912 0,11673541 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,0834912 0,11666449 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,0834912 0,11659366 ! alditol metabolic process GO:0019400 24 20 0,000 0,0834912 0,11652291 ! actin filament-based movement GO:0030048 34 20 0,000 0,0834912 0,11645224 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,08748012 0,12194199 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,08748012 0,12186813 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,08748012 0,12179436 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,08748012 0,12172068 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,08748012 0,12164709 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,08748012 0,12157359 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,08748012 0,12150017 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,08748012 0,12142685 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,08748012 0,12135361 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,08748012 0,12128046 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,08748012 0,1212074 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,08748012 0,12113443 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,08748012 0,12106154 ! vesicle docking GO:0048278 27 21 0,000 0,08748012 0,12098875 ! phototransduction GO:0007602 25 21 0,000 0,08748012 0,12091604 ! dendrite development GO:0016358 35 21 0,000 0,08748012 0,12084342 ! visual behavior GO:0007632 39 21 0,000 0,08748012 0,12077088 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,08748012 0,12069843 ! ovarian follicle development GO:0001541 30 21 0,000 0,08748012 0,12062607 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,08748012 0,1205538 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,08748012 0,12048161 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,08748012 0,12040951 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,08748012 0,12033749 ! cell aging GO:0007569 32 21 0,000 0,08748012 0,12026556 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,08748012 0,12019372 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,08748012 0,12012196 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,08748012 0,12005029 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,08748012 0,1199787 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,08748012 0,1199072 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,08748012 0,11983579 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,08748012 0,11976446 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,08748012 0,11969321 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,08748012 0,11962205 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,08748012 0,11955097 ! fatty acid transport GO:0015908 30 21 0,000 0,08748012 0,11947998 ! immunoglobulin production GO:0002377 33 21 0,000 0,08748012 0,11940907 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,08748012 0,11933825 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,08748012 0,11926751 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,08748012 0,11919685 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,08748012 0,11912628 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,08748012 0,11905579 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,08748012 0,11898539 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,08748012 0,11891506 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,08748012 0,11884482 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,08748012 0,11877467 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,08748012 0,11870459 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,08748012 0,1186346 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,08748012 0,11856469 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,08748012 0,11849487 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,08748012 0,11842512 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,09145192 0,12372907 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,09145192 0,12365633 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,09145192 0,12358367 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,09145192 0,12351111 ! leukocyte adhesion GO:0007159 38 22 0,000 0,09145192 0,12343862 ! molting cycle process GO:0022404 40 22 0,000 0,09145192 0,12336623 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,09145192 0,12329391 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,09145192 0,12322168 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,09145192 0,12314954 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,09145192 0,12307748 ! vasculogenesis GO:0001570 33 22 0,000 0,09145192 0,12300551 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,09145192 0,12293361 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,09145192 0,12286181 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,09145192 0,12279008 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,09145192 0,12271844 ! lysosome organization GO:0007040 37 22 0,000 0,09145192 0,12264689 ! ureteric bud development GO:0001657 32 22 0,000 0,09145192 0,12257542 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,09145192 0,12250403 ! regulation of behavior GO:0050795 38 22 0,000 0,09145192 0,12243272 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,09145192 0,1223615 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,09145192 0,12229036 ! membrane depolarization GO:0051899 35 22 0,000 0,09145192 0,1222193 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,09145192 0,12214832 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,09145192 0,12207743 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,09145192 0,12200662 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,09145192 0,12193589 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,09145192 0,12186525 ! blastocyst development GO:0001824 37 22 0,000 0,09145192 0,12179468 ! neural tube closure GO:0001843 33 22 0,000 0,09145192 0,1217242 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,09145192 0,1216538 ! protein tetramerization GO:0051262 39 22 0,000 0,09145192 0,12158348 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,09540665 0,12676794 ! neuron fate commitment GO:0048663 32 23 0,000 0,09540665 0,12669475 ! embryonic pattern specification GO:0009880 31 23 0,000 0,09540665 0,12662164 ! myelination GO:0042552 35 23 0,000 0,09540665 0,12654862 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,09540665 0,12647568 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,09540665 0,12640282 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,09540665 0,12633005 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,09540665 0,12625737 ! vesicle targeting GO:0006903 32 23 0,000 0,09540665 0,12618476 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,09540665 0,12611224 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,09540665 0,12603981 ! osteoblast differentiation GO:0001649 40 23 0,000 0,09540665 0,12596745 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,09540665 0,12589518 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,09540665 0,12582299 ! interaction with host GO:0051701 37 23 0,000 0,09540665 0,12575089 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,09540665 0,12567887 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,09540665 0,12560693 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,09540665 0,12553507 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,09540665 0,12546329 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,09540665 0,1253916 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,09540665 0,12531999 ! pentose metabolic process GO:0019321 31 23 0,000 0,09540665 0,12524846 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,09540665 0,12517701 ! spermatid development GO:0007286 33 23 0,000 0,09540665 0,12510565 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,09540665 0,12503436 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,09540665 0,12496316 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,09540665 0,12489203 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,09540665 0,12482099 ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,09540665 0,12475003 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,09540665 0,12467915 ! regulation of amine transport GO:0051952 38 23 0,000 0,09540665 0,12460835 ! liver development GO:0001889 40 23 0,000 0,09540665 0,12453763 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,0993444 0,12960415 ! initiation of viral infection GO:0019059 42 24 0,000 0,0993444 0,12953068 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,0993444 0,12945729 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,0993444 0,12938398 ! superoxide metabolic process GO:0006801 32 24 0,000 0,0993444 0,12931076 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,0993444 0,12923762 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,0993444 0,12916457 ! fat cell differentiation GO:0045444 37 24 0,000 0,0993444 0,12909159 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,0993444 0,1290187 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,0993444 0,12894589 ! vacuole organization GO:0007033 39 24 0,000 0,0993444 0,12887316 ! receptor metabolic process GO:0043112 37 24 0,000 0,0993444 0,12880052 ! response to toxin GO:0009636 38 24 0,000 0,0993444 0,12872795 ! primary neural tube formation GO:0014020 35 24 0,000 0,0993444 0,12865547 ! negative regulation of cell development GO:0010721 56 24 0,000 0,0993444 0,12858307 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,0993444 0,12851075 ! base-excision repair GO:0006284 31 24 0,000 0,0993444 0,12843851 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,0993444 0,12836636 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,0993444 0,12829428 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,0993444 0,12822229 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,0993444 0,12815037 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,10326523 0,13313342 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,10326523 0,13305884 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,10326523 0,13298434 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,10326523 0,13290992 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,10326523 0,13283558 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,10326523 0,13276133 ! peptide transport GO:0015833 43 25 0,000 0,10326523 0,13268716 ! male gonad development GO:0008584 33 25 0,000 0,10326523 0,13261308 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,10326523 0,13253908 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,10326523 0,13246515 ! phospholipid transport GO:0015914 35 25 0,000 0,10326523 0,13239132 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,10326523 0,13231756 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,10326523 0,13224389 ! detection of light stimulus GO:0009583 30 25 0,000 0,10326523 0,1321703 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,10326523 0,13209679 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,10326523 0,13202336 ! leukocyte proliferation GO:0070661 39 25 0,000 0,10326523 0,13195001 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,10326523 0,13187675 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,10716921 0,13678645 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,10716921 0,13671059 ! translational initiation GO:0006413 43 26 0,000 0,10716921 0,1366348 ! regulation of pH GO:0006885 36 26 0,000 0,10716921 0,13655911 ! circadian rhythm GO:0007623 42 26 0,000 0,10716921 0,13648349 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,10716921 0,13640796 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,10716921 0,13633251 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,10716921 0,13625715 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,10716921 0,13618187 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,10716921 0,13610667 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,10716921 0,13603156 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,10716921 0,13595653 ! regulation of coagulation GO:0050818 39 26 0,000 0,10716921 0,13588158 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,11105642 0,14073265 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,11105642 0,14065516 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,11105642 0,14057775 ! membrane docking GO:0022406 39 27 0,000 0,11105642 0,14050042 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,11105642 0,14042318 ! catechol metabolic process GO:0009712 43 27 0,000 0,11105642 0,14034603 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,11105642 0,14026896 ! acute-phase response GO:0006953 42 27 0,000 0,11105642 0,14019197 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,11105642 0,14011507 ! myofibril assembly GO:0030239 36 27 0,000 0,11105642 0,14003825 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,11105642 0,13996152 ! response to ionizing radiation GO:0010212 47 27 0,000 0,11105642 0,13988487 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,11105642 0,1398083 ! natural killer cell activation GO:0030101 35 27 0,000 0,11105642 0,13973182 ! lipid oxidation GO:0034440 38 27 0,000 0,11105642 0,13965542 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,11105642 0,13957911 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,11105642 0,13950288 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,11105642 0,13942673 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,11105642 0,13935066 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,11105642 0,13927468 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,11105642 0,13919878 ! gene silencing GO:0016458 41 27 0,000 0,11105642 0,13912297 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,11492693 0,14389327 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,11492693 0,14381498 ! phenol metabolic process GO:0018958 44 28 0,000 0,11492693 0,14373678 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,11492693 0,14365866 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,11492693 0,14358063 ! cell junction assembly GO:0034329 56 28 0,000 0,11492693 0,14350268 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,11492693 0,14342482 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,11492693 0,14334704 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,11492693 0,14326934 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,11492693 0,14319173 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,11492693 0,1431142 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,11492693 0,14303676 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,11492693 0,1429594 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,11492693 0,14288213 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,11492693 0,14280494 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,11492693 0,14272783 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,11492693 0,1426508 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,11492693 0,14257386 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,11492693 0,142497 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,11492693 0,14242022 ! ensheathment of neurons GO:0007272 43 28 0,000 0,11492693 0,14234353 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,11492693 0,14226692 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,11492693 0,14219039 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,11492693 0,14211394 ! neural tube formation GO:0001841 41 28 0,000 0,11492693 0,14203758 ! regulation of B cell activation GO:0050864 42 28 0,000 0,11492693 0,1419613 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,1187808 0,14664297 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1187808 0,1465643 ! ovulation cycle process GO:0022602 41 29 0,000 0,1187808 0,14648571 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,1187808 0,14640721 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1187808 0,14632879 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1187808 0,14625046 ! mismatch repair GO:0006298 34 29 0,000 0,1187808 0,1461722 ! muscle cell development GO:0055001 38 29 0,000 0,1187808 0,14609404 ! telencephalon development GO:0021537 52 29 0,000 0,1187808 0,14601595 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1187808 0,14593795 ! eye morphogenesis GO:0048592 51 29 0,000 0,1187808 0,14586004 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1187808 0,1457822 ! tissue homeostasis GO:0001894 42 29 0,000 0,1187808 0,14570445 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,12261812 0,15033138 ! organic anion transport GO:0015711 51 30 0,000 0,12261812 0,15025129 ! cholesterol transport GO:0030301 46 30 0,000 0,12261812 0,15017129 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,12261812 0,15009137 ! spliceosome assembly GO:0000245 49 30 0,000 0,12261812 0,15001153 ! spindle organization GO:0007051 37 30 0,000 0,12261812 0,14993178 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,12261812 0,14985211 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,12261812 0,14977253 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,12261812 0,14969303 ! ceramide metabolic process GO:0006672 43 30 0,000 0,12261812 0,14961362 ! ovulation cycle GO:0042698 43 30 0,000 0,12261812 0,14953429 ! hindbrain development GO:0030902 45 30 0,000 0,12261812 0,14945505 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,12261812 0,14937589 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,12261812 0,14929681 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,12261812 0,14921782 ! response to heat GO:0009408 41 30 0,000 0,12261812 0,14913891 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,12261812 0,14906008 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,12261812 0,14898134 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,12643894 0,15354254 ! negative regulation of secretion GO:0051048 49 31 0,000 0,12643894 0,15346152 ! glial cell differentiation GO:0010001 55 31 0,000 0,12643894 0,15338058 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,12643894 0,15329972 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,12643894 0,15321895 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,12643894 0,15313827 ! odontogenesis GO:0042476 50 31 0,000 0,12643894 0,15305767 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,12643894 0,15297715 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,12643894 0,15289673 ! metanephros development GO:0001656 58 31 0,000 0,12643894 0,15281638 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,12643894 0,15273612 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,12643894 0,15265594 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,12643894 0,15257585 ! regulation of muscle development GO:0048634 48 32 0,000 0,13024335 0,15708427 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,13024335 0,15700194 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,13024335 0,1569197 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,13024335 0,15683754 ! meiosis I GO:0007127 52 32 0,000 0,13024335 0,15675547 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,13024335 0,15667348 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,13024335 0,15659158 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,13024335 0,15650977 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,13024335 0,15642804 ! peripheral nervous system development GO:0007422 53 32 0,000 0,13024335 0,1563464 ! regulation of protein stability GO:0031647 48 32 0,000 0,13024335 0,15626484 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,13024335 0,15618337 ! cytokine production GO:0001816 44 32 0,000 0,13024335 0,15610198 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,13024335 0,15602068 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,13024335 0,15593946 ! vesicle localization GO:0051648 47 32 0,000 0,13024335 0,15585832 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,1340314 0,16030797 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,1340314 0,16022465 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,1340314 0,16014141 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,1340314 0,16005826 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,1340314 0,1599752 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,1340314 0,15989223 ! sister chromatid segregation GO:0000819 46 33 0,000 0,1340314 0,15980934 ! ear morphogenesis GO:0042471 42 33 0,000 0,1340314 0,15972654 ! actomyosin structure organization GO:0031032 43 33 0,000 0,1340314 0,15964382 ! cell junction organization GO:0034330 63 33 0,000 0,1340314 0,15956119 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,1340314 0,15947864 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,1340314 0,15939618 ! nucleus organization GO:0006997 49 33 0,000 0,1340314 0,15931381 ! female gonad development GO:0008585 49 33 0,000 0,1340314 0,15923152 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,1340314 0,15914931 ! positive regulation of cell development GO:0010720 54 33 0,000 0,1340314 0,15906719 ! lipid homeostasis GO:0055088 55 33 0,000 0,1340314 0,15898516 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,1340314 0,15890321 ! regulation of proteolysis GO:0030162 50 33 0,000 0,1340314 0,15882134 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,1340314 0,15873956 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,1340314 0,15865786 ! cytokinesis GO:0000910 52 33 0,000 0,1340314 0,15857624 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,13780317 0,1629549 ! mRNA catabolic process GO:0006402 48 34 0,000 0,13780317 0,16287117 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,13780317 0,16278751 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,13780317 0,16270395 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,13780317 0,16262047 ! feeding behavior GO:0007631 45 34 0,000 0,13780317 0,16253707 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,13780317 0,16245376 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,13780317 0,16237054 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,13780317 0,1622874 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,13780317 0,16220434 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,13780317 0,16212138 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,13780317 0,16203849 ! female gamete generation GO:0007292 43 34 0,000 0,13780317 0,16195569 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,13780317 0,16187298 ! polyol metabolic process GO:0019751 44 34 0,000 0,13780317 0,16179035 ! aerobic respiration GO:0009060 47 34 0,000 0,13780317 0,1617078 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,13780317 0,16162534 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,13780317 0,16154296 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,13780317 0,16146067 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,14155873 0,16577651 ! Notch signaling pathway GO:0007219 56 35 0,000 0,14155873 0,16569215 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,14155873 0,16560787 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,14155873 0,16552368 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,14155873 0,16543957 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,14155873 0,16535555 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,14155873 0,16527161 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,14155873 0,16518776 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,14155873 0,16510399 ! glycogen metabolic process GO:0005977 48 35 0,000 0,14155873 0,16502031 ! pigment metabolic process GO:0042440 61 35 0,000 0,14155873 0,16493671 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,14155873 0,1648532 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,14529814 0,16912233 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,14529814 0,16903678 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,14529814 0,16895132 ! negative regulation of binding GO:0051100 58 36 0,000 0,14529814 0,16886595 ! organic ether metabolic process GO:0018904 46 36 0,000 0,14529814 0,16878067 ! neural tube development GO:0021915 50 36 0,000 0,14529814 0,16869547 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,14529814 0,16861035 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,14529814 0,16852532 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,14529814 0,16844038 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,14529814 0,16835553 ! glucan metabolic process GO:0044042 49 36 0,000 0,14529814 0,16827075 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,14902148 0,17249592 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,14902148 0,17240915 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,14902148 0,17232247 ! learning GO:0007612 67 37 0,000 0,14902148 0,17223588 ! ion transmembrane transport GO:0034220 56 37 0,000 0,14902148 0,17214937 ! regulation of protein secretion GO:0050708 51 37 0,000 0,14902148 0,17206295 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,14902148 0,17197662 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,15272881 0,17616663 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,15272881 0,17607832 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,15272881 0,17599011 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,15272881 0,17590198 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,15272881 0,17581394 ! phagocytosis GO:0006909 60 38 0,000 0,15272881 0,17572599 ! pigmentation GO:0043473 74 38 0,000 0,15272881 0,17563813 ! maintenance of location in cell GO:0051651 69 38 0,000 0,15272881 0,17555035 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,1564202 0,17970352 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,1564202 0,1796138 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,1564202 0,17952418 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,1564202 0,17943464 ! male sex differentiation GO:0046661 53 39 0,000 0,1564202 0,17934519 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,1564202 0,17925583 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,1564202 0,17916656 ! JNK cascade GO:0007254 54 39 0,000 0,1564202 0,17907738 ! developmental growth GO:0048589 62 39 0,000 0,1564202 0,17898828 ! synapse organization GO:0050808 55 39 0,000 0,1564202 0,17889928 ! response to calcium ion GO:0051592 58 40 0,000 0,16009571 0,183012 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,16009571 0,18292108 ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,16009571 0,18283026 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,16009571 0,18273953 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,16009571 0,18264888 ! peptide metabolic process GO:0006518 56 40 0,000 0,16009571 0,18255833 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,16009571 0,18246786 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,16009571 0,18237749 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,16009571 0,1822872 ! double-strand break repair GO:0006302 67 40 0,000 0,16009571 0,182197 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,16375543 0,18626977 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,16375543 0,1861777 ! glucose transport GO:0015758 52 41 0,000 0,16375543 0,18608571 ! endosome transport GO:0016197 71 41 0,000 0,16375543 0,18599382 ! striated muscle contraction GO:0006941 62 41 0,000 0,16375543 0,18590202 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,16375543 0,1858103 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,16375543 0,18571868 ! biopolymer methylation GO:0043414 62 41 0,000 0,16375543 0,18562715 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,16375543 0,18553571 ! mitochondrial transport GO:0006839 60 42 0,000 0,1673994 0,18957096 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,1673994 0,18947767 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,1673994 0,18938447 ! cellular component disassembly GO:0022411 64 42 0,000 0,1673994 0,18929136 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,1673994 0,18919834 ! hexose transport GO:0008645 54 42 0,000 0,1673994 0,18910542 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,1673994 0,18901258 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,1673994 0,18891984 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,1673994 0,18882718 ! excretion GO:0007588 63 42 0,000 0,1673994 0,18873462 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,1673994 0,18864215 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,1673994 0,18854977 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,1673994 0,18845748 ! regulation of cell shape GO:0008360 78 42 0,000 0,1673994 0,18836528 ! activation of caspase activity GO:0006919 65 43 0,000 0,17102771 0,1923539 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,17102771 0,19225989 ! tRNA processing GO:0008033 49 43 0,000 0,17102771 0,19216597 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,17102771 0,19207213 ! vesicle organization GO:0016050 79 43 0,000 0,17102771 0,1919784 ! response to insulin stimulus GO:0032868 63 43 0,000 0,17102771 0,19188475 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,17102771 0,19179119 ! methylation GO:0032259 64 43 0,000 0,17102771 0,19169773 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,17464041 0,1956517 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,17464041 0,19555645 ! glycolysis GO:0006096 53 44 0,000 0,17464041 0,19546129 ! regulation of action potential GO:0001508 71 44 0,000 0,17464041 0,19536622 ! regulation of ion transport GO:0043269 57 44 0,000 0,17464041 0,19527124 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,17464041 0,19517636 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,17464041 0,19508157 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,17464041 0,19498687 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,17464041 0,19489226 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,17464041 0,19479774 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,17464041 0,19470332 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,17464041 0,19460898 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,17464041 0,19451474 ! RNA catabolic process GO:0006401 64 45 0,000 0,17823757 0,19842518 ! positive regulation of defense response GO:0031349 59 45 0,000 0,17823757 0,19832918 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,17823757 0,19823328 ! cell recognition GO:0008037 58 45 0,000 0,17823757 0,19813747 ! cell maturation GO:0048469 60 45 0,000 0,17823757 0,19804175 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,18181926 0,20192386 ! cell redox homeostasis GO:0045454 63 46 0,000 0,18181926 0,2018264 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,18181926 0,20172904 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,18181926 0,20163178 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,18538555 0,2054876 ! endocrine system development GO:0035270 83 47 0,000 0,18538555 0,20538861 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,18538555 0,20528973 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,18538555 0,20519093 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,18538555 0,20509224 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,18538555 0,20499364 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,18538555 0,20489513 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,18538555 0,20479672 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,18893649 0,20861927 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,18893649 0,20851916 ! response to temperature stimulus GO:0009266 62 48 0,000 0,18893649 0,20841915 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,18893649 0,20831924 ! regulation of DNA replication GO:0006275 75 48 0,000 0,18893649 0,20821942 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,18893649 0,2081197 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,18893649 0,20802007 ! regulation of endocytosis GO:0030100 63 48 0,000 0,18893649 0,20792054 ! nuclear export GO:0051168 69 48 0,000 0,18893649 0,20782111 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,18893649 0,20772177 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,19247216 0,21150787 ! sensory perception of smell GO:0007608 61 49 0,000 0,19247216 0,21140686 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,19247216 0,21130595 ! RNA elongation GO:0006354 62 49 0,000 0,19247216 0,21120514 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,19247216 0,21110442 ! germ cell development GO:0007281 68 49 0,000 0,19247216 0,2110038 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,19247216 0,21090327 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,19247216 0,21080284 ! maintenance of location GO:0051235 84 49 0,000 0,19247216 0,21070251 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,19599262 0,21445434 ! membrane fusion GO:0006944 80 50 0,000 0,19599262 0,21435236 ! lipid modification GO:0030258 73 50 0,000 0,19599262 0,21425048 ! positive regulation of growth GO:0045927 67 50 0,000 0,19599262 0,2141487 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,19599262 0,21404702 ! proton transport GO:0015992 75 50 0,000 0,19599262 0,21394543 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,19599262 0,21384394 ! positive regulation of secretion GO:0051047 71 51 0,000 0,19949793 0,21756531 ! hydrogen transport GO:0006818 77 51 0,000 0,19949793 0,21746219 ! muscle fiber development GO:0048747 74 51 0,000 0,19949793 0,21735918 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,19949793 0,21725626 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,19949793 0,21715345 ! aging GO:0007568 79 52 0,000 0,20298815 0,22084804 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,20298815 0,22074362 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,20298815 0,2206393 ! establishment of organelle localization GO:0051656 85 52 0,000 0,20298815 0,22053507 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,20646336 0,22420479 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,20646336 0,22409898 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,20646336 0,22399327 ! kidney development GO:0001822 90 53 0,000 0,20646336 0,22388766 ! single fertilization GO:0007338 59 53 0,000 0,20646336 0,22378216 ! amino acid transport GO:0006865 84 54 0,000 0,20992362 0,22742549 ! regulation of mitosis GO:0007088 84 54 0,000 0,20992362 0,22731842 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,20992362 0,22721145 ! DNA catabolic process GO:0006308 67 54 0,000 0,20992362 0,22710457 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,20992362 0,2269978 ! exocytosis GO:0006887 74 55 0,000 0,21336898 0,23061497 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,21336898 0,23050665 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,21679952 0,23410277 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,21679952 0,23399291 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,21679952 0,23388316 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,22021529 0,23745671 ! carbohydrate transport GO:0008643 74 57 0,000 0,22021529 0,23734544 ! chromosome segregation GO:0007059 83 57 0,000 0,22021529 0,23723427 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,22021529 0,23712321 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,22021529 0,23701224 ! secondary metabolic process GO:0019748 84 57 0,000 0,22021529 0,23690139 ! developmental maturation GO:0021700 75 57 0,000 0,22021529 0,23679063 ! gonad development GO:0008406 79 57 0,000 0,22021529 0,23667998 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,22361636 0,24022309 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,22361636 0,24011094 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,22361636 0,23999889 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,22700279 0,24351978 ! activation of MAPK activity GO:0000187 84 59 0,000 0,22700279 0,24340625 ! actin filament organization GO:0007015 95 59 0,000 0,22700279 0,24329283 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,23037464 0,24679165 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,23037464 0,24667676 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,23037464 0,24656197 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,23037464 0,24644729 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,23037464 0,24633272 ! regulation of heart contraction GO:0008016 91 60 0,000 0,23037464 0,24621825 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,23037464 0,24610389 ! fertilization GO:0009566 68 60 0,000 0,23037464 0,24598964 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,23373198 0,24945873 ! meiosis GO:0007126 96 61 0,000 0,23373198 0,24934302 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,23373198 0,24922742 ! urogenital system development GO:0001655 101 61 0,000 0,23373198 0,24911193 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,23373198 0,24899655 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,23373198 0,24888127 ! extracellular matrix organization GO:0030198 103 61 0,000 0,23373198 0,2487661 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,23373198 0,24865104 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,23373198 0,24853609 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,23373198 0,24842124 ! amine catabolic process GO:0009310 90 62 0,000 0,23707486 0,25185782 ! neurotransmitter transport GO:0006836 81 62 0,000 0,23707486 0,25174154 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,23707486 0,25162537 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,23707486 0,25150931 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,23707486 0,25139335 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,23707486 0,2512775 ! meiotic cell cycle GO:0051321 97 62 0,000 0,23707486 0,25116176 ! organelle localization GO:0051640 96 62 0,000 0,23707486 0,25104613 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,24040335 0,25445362 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,24371751 0,25784282 ! negative regulation of cell size GO:0045792 108 64 0,000 0,24371751 0,25772427 ! appendage morphogenesis GO:0035107 93 64 0,000 0,24371751 0,25760583 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,24371751 0,2574875 ! hexose catabolic process GO:0019320 82 64 0,000 0,24371751 0,25736927 ! adaptive immune response GO:0002250 94 64 0,000 0,24371751 0,25725116 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,2470174 0,26061469 ! appendage development GO:0048736 94 65 0,000 0,2470174 0,2604952 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,2470174 0,26037581 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,2470174 0,26025654 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,2470174 0,26013737 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,2470174 0,26001832 ! activation of immune response GO:0002253 83 65 0,000 0,2470174 0,25989937 ! antigen processing and presentation GO:0019882 96 66 0,000 0,25030308 0,26323598 ! axon guidance GO:0007411 99 66 0,000 0,25030308 0,26311567 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,25030308 0,26299547 ! regulation of immune effector process GO:0002697 101 66 0,000 0,25030308 0,26287538 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,25357461 0,26618969 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,25357461 0,26606825 ! acute inflammatory response GO:0002526 92 68 0,000 0,25683205 0,2693633 ! learning or memory GO:0007611 123 68 0,000 0,25683205 0,26924053 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,25683205 0,26911787 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,25683205 0,26899532 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,25683205 0,26887288 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,25683205 0,26875056 ! rhythmic process GO:0048511 105 68 0,000 0,25683205 0,26862834 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,26007546 0,27189708 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,26007546 0,27177354 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,26007546 0,27165012 ! response to metal ion GO:0010038 103 70 0,000 0,26330491 0,27489845 ! amine transport GO:0015837 101 70 0,000 0,26330491 0,27477372 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,26330491 0,27464911 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,26652044 0,27787715 ! muscle cell differentiation GO:0042692 104 71 0,000 0,26652044 0,27775125 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,26652044 0,27762545 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,26652044 0,27749978 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,26652044 0,27737421 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,26972212 0,28057932 ! negative regulation of transport GO:0051051 116 73 0,000 0,27291 0,28376718 ! regulation of blood pressure GO:0008217 107 73 0,000 0,27291 0,28363896 ! tube morphogenesis GO:0035239 118 73 0,000 0,27291 0,28351084 ! mitochondrion organization GO:0007005 104 73 0,000 0,27291 0,28338285 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,27608416 0,28654944 ! digestion GO:0007586 97 74 0,000 0,27608416 0,28642019 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,27608416 0,28629106 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,27608416 0,28616204 ! blood coagulation GO:0007596 116 75 0,000 0,27924464 0,2893075 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,27924464 0,28917724 ! response to nutrient GO:0007584 104 75 0,000 0,27924464 0,2890471 ! regulation of ligase activity GO:0051340 114 75 0,000 0,27924464 0,28891708 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,27924464 0,28878717 ! amine biosynthetic process GO:0009309 97 76 0,000 0,2823915 0,29191031 ! response to unfolded protein GO:0006986 99 76 0,000 0,2823915 0,29177917 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,2823915 0,29164815 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,2855248 0,29475181 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,2855248 0,29461958 ! sex differentiation GO:0007548 105 77 0,000 0,2855248 0,29448746 ! protein ubiquitination GO:0016567 125 77 0,000 0,2855248 0,29435546 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,2855248 0,29422358 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,2855248 0,29409182 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,2855248 0,29396018 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,2886446 0,29703918 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,2886446 0,29690634 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,29175095 0,29996745 ! cellular respiration GO:0045333 107 79 0,000 0,29175095 0,29983342 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,29175095 0,2996995 ! T cell activation GO:0042110 134 79 0,000 0,29175095 0,29956571 ! regulation of lyase activity GO:0051339 133 79 0,000 0,29175095 0,29943204 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,29175095 0,29929848 ! chromatin assembly GO:0031497 102 80 0,000 0,29484392 0,30233661 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,29484392 0,30220188 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,29484392 0,30206727 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,29484392 0,30193278 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,29792356 0,30495068 ! hemostasis GO:0007599 125 81 0,000 0,29792356 0,30481503 ! mRNA transport GO:0051028 121 81 0,000 0,29792356 0,3046795 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,29792356 0,30454408 ! response to protein stimulus GO:0051789 111 81 0,000 0,29792356 0,30440879 ! vitamin metabolic process GO:0006766 103 81 0,000 0,29792356 0,30427362 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,29792356 0,30413856 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,30404307 0,31024803 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,30404307 0,31011045 ! regulation of defense response GO:0031347 117 84 0,000 0,30708306 0,31307227 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,30708306 0,31293355 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,30708306 0,31279497 ! sterol metabolic process GO:0016125 120 84 0,000 0,30708306 0,3126565 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,31010994 0,31559861 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,31010994 0,31545903 ! transcription initiation GO:0006352 118 85 0,000 0,31010994 0,31531957 ! regulation of membrane potential GO:0042391 128 85 0,000 0,31010994 0,31518023 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,31010994 0,31504102 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,31312377 0,31796233 ! cell cycle arrest GO:0007050 150 86 0,000 0,31312377 0,31782201 ! nucleosome organization GO:0034728 114 87 0,000 0,31612461 0,32072634 ! cellular defense response GO:0006968 102 87 0,000 0,31612461 0,32058492 ! female pregnancy GO:0007565 130 87 0,000 0,31612461 0,32044363 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,31911251 0,32332986 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,31911251 0,32318748 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,31911251 0,32304524 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,32208753 0,32591347 ! reproductive developmental process GO:0003006 127 89 0,000 0,32208753 0,32577015 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,32208753 0,32562695 ! regulation of T cell activation GO:0050863 128 89 0,000 0,32208753 0,32548388 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,32504972 0,32833305 ! hormone metabolic process GO:0042445 121 90 0,000 0,32504972 0,32818892 ! RNA localization GO:0006403 135 91 0,000 0,32799913 0,3310215 ! ATP metabolic process GO:0046034 137 91 0,000 0,32799913 0,33087632 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,33093583 0,33369242 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,33093583 0,33354619 ! positive regulation of immune response GO:0050778 121 92 0,000 0,33093583 0,33340009 ! DNA recombination GO:0006310 146 92 0,000 0,33093583 0,33325412 ! sulfur metabolic process GO:0006790 118 92 0,000 0,33093583 0,33310827 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,33385986 0,33590449 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,33385986 0,33575762 ! electron transport chain GO:0022900 123 94 0,000 0,33677128 0,33853756 ! carboxylic acid transport GO:0046942 147 95 0,000 0,33967014 0,34130245 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,34255649 0,34405237 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,34255649 0,3439022 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,34255649 0,34375215 ! protein maturation GO:0051604 129 96 0,000 0,34255649 0,34360224 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,3454304 0,34633388 ! calcium ion transport GO:0006816 167 99 0,000 0,35114106 0,35190608 ! extracellular structure organization GO:0043062 156 99 0,000 0,35114106 0,35175281 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,35397793 0,35444025 ! divalent metal ion transport GO:0070838 171 100 0,000 0,35397793 0,35428601 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,35397793 0,3541319 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,35397793 0,35397793