pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1098-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 10 5 2,000 6,659E-07 1,532E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 6,659E-07 7,658E-04 GO:0031272|regulation of pseudopodium assembly, ! macrophage differentiation GO:0030225 10 6 2,000 1,328E-06 1,018E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 2,317E-06 1,332E-03 ! protein heterooligomerization GO:0051291 10 7 2,000 2,317E-06 1,066E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 2,317E-06 8,881E-04 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 3,000 2,64E-06 8,675E-04 ! nucleus localization GO:0051647 15 9 2,000 5,528E-06 1,589E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 7,873E-06 2,012E-03 ! filopodium assembly GO:0046847 19 11 2,000 1,079E-05 2,483E-03 ! microspike assembly GO:0030035 23 12 2,000 1,435E-05 3E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 2,89E-05 5,54E-03 ! response to UV GO:0009411 75 46 3,000 3,787E-05 6,699E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 4,37E-05 7,179E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 7,262E-05 0,01113441 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 8,447E-05 0,0121423 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 8,447E-05 0,01142804 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 9,752E-05 0,01246044 ! protein tetramerization GO:0051262 39 22 2,000 9,752E-05 0,01180462 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 1,118E-04 0,01285848 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 1,274E-04 0,01395431 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 1,274E-04 0,01332003 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 1,444E-04 0,01443556 ! protein oligomerization GO:0051259 100 65 3,000 1,481E-04 0,01419317 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,659E-04 0,01526649 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,659E-04 0,01467932 ! epithelial cell proliferation GO:0050673 6 5 1,000 1,659E-04 0,01413564 ! negative regulation of multicellular organism growth GO:0040015 7 5 1,000 1,659E-04 0,0136308 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,659E-04 0,01316077 ! response to drug GO:0042493 108 69 3,000 1,868E-04 0,01431971 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 2,038E-04 0,01512051 ! regulation of helicase activity GO:0051095 11 6 1,000 2,482E-04 0,0178427 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,482E-04 0,01730201 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 2,482E-04 0,01679313 ! ER overload response GO:0006983 7 6 1,000 2,482E-04 0,01631333 ! male sex determination GO:0030238 9 6 1,000 2,482E-04 0,01586018 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 2,482E-04 0,01543153 ! negative regulation of growth GO:0045926 123 75 3,000 2,578E-04 0,01560155 ! DNA damage checkpoint GO:0000077 53 31 2,000 2,772E-04 0,01634563 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,466E-04 0,01993054 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 3,466E-04 0,01944443 ! B cell lineage commitment GO:0002326 17 7 1,000 3,466E-04 0,01898146 ! T cell lineage commitment GO:0002360 12 7 1,000 3,466E-04 0,01854004 ! response to tumor cell GO:0002347 12 7 1,000 3,466E-04 0,01811867 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 3,657E-04 0,01869261 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 3,657E-04 0,01828625 ! DNA integrity checkpoint GO:0031570 57 34 2,000 3,657E-04 0,01789718 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 3,657E-04 0,01752432 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 4,163E-04 0,01954104 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 4,353E-04 0,0200223 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 4,609E-04 0,02078683 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 4,609E-04 0,02038708 ! keratinocyte proliferation GO:0043616 12 8 1,000 4,609E-04 0,02000242 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 4,609E-04 0,01963201 ! regulation of smoothened signaling pathway GO:0008589 13 8 1,000 4,609E-04 0,01927506 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 4,609E-04 0,01893086 ! induction of an organ GO:0001759 11 8 1,000 4,609E-04 0,01859874 ! regulation of embryonic development GO:0045995 16 8 1,000 4,609E-04 0,01827808 ! interphase GO:0051325 159 88 3,000 4,75E-04 0,01851776 ! leukocyte differentiation GO:0002521 143 90 3,000 5,173E-04 0,01982972 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 5,504E-04 0,02075172 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 5,856E-04 0,0217253 ! regulation of developmental growth GO:0048638 13 9 1,000 5,91E-04 0,02157761 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 5,91E-04 0,02124046 ! regulation of glycolysis GO:0006110 15 9 1,000 5,91E-04 0,02091369 ! localization within membrane GO:0051668 15 9 1,000 5,91E-04 0,02059681 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 5,932E-04 0,02036511 ! response to light stimulus GO:0009416 153 96 3,000 6,602E-04 0,02232904 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 7,345E-04 0,02448306 ! response to insulin stimulus GO:0032868 63 43 2,000 7,345E-04 0,0241333 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 7,368E-04 0,02386915 ! regulation of B cell proliferation GO:0030888 15 10 1,000 7,368E-04 0,02353764 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 7,368E-04 0,0232152 ! response to X-ray GO:0010165 16 10 1,000 7,368E-04 0,02290149 ! DNA methylation GO:0006306 15 10 1,000 7,368E-04 0,02259613 GO:0006305|DNA alkylation, ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 7,368E-04 0,02229881 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 7,368E-04 0,02200922 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of cell projection organization GO:0031344 83 44 2,000 7,859E-04 0,02317444 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 8,396E-04 0,02444334 ! virus-host interaction GO:0019048 17 11 1,000 8,982E-04 0,02582244 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 8,982E-04 0,02550364 ! regulation of intracellular pH GO:0051453 17 11 1,000 8,982E-04 0,02519262 ! regulation of DNA replication GO:0006275 75 48 2,000 1,014E-03 0,02810836 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,075E-03 0,02943278 ! cell-cell junction assembly GO:0007043 18 12 1,000 1,075E-03 0,02908651 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,075E-03 0,0287483 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,075E-03 0,02841786 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,075E-03 0,02809493 ! response to gamma radiation GO:0010332 20 12 1,000 1,075E-03 0,02777925 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,211E-03 0,03093678 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,211E-03 0,03059681 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,267E-03 0,03167494 ! regulation of cellular pH GO:0030641 20 13 1,000 1,267E-03 0,03133435 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,267E-03 0,03100101 ! establishment of organelle localization GO:0051656 85 52 2,000 1,281E-03 0,03101153 ! cell projection assembly GO:0030031 76 53 2,000 1,354E-03 0,03243423 ! regulation of protein complex assembly GO:0043254 81 54 2,000 1,429E-03 0,03388824 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,474E-03 0,03459929 ! cellular response to starvation GO:0009267 21 14 1,000 1,474E-03 0,0342498 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,474E-03 0,0339073 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,474E-03 0,03357158 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,474E-03 0,03324245 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 1,588E-03 0,03545687 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 1,588E-03 0,03511594 ! positive regulation of cell motion GO:0051272 99 56 2,000 1,588E-03 0,0347815 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 1,671E-03 0,03626068 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 1,671E-03 0,03592179 ! lipid phosphorylation GO:0046834 23 15 1,000 1,697E-03 0,03612938 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,697E-03 0,03579791 ! negative regulation of kinase activity GO:0033673 100 58 2,000 1,757E-03 0,03673987 ! lung development GO:0030324 94 59 2,000 1,846E-03 0,03824676 ! myeloid cell differentiation GO:0030099 85 59 2,000 1,846E-03 0,03790527 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,934E-03 0,03935874 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,934E-03 0,03901348 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,934E-03 0,03867424 ! negative regulation of transferase activity GO:0051348 105 61 2,000 2,031E-03 0,04027962 ! negative regulation of cell growth GO:0030308 106 62 2,000 2,129E-03 0,04184284 ! respiratory tube development GO:0030323 99 62 2,000 2,129E-03 0,04148824 ! organelle localization GO:0051640 96 62 2,000 2,129E-03 0,0411396 ! cell-cell junction organization GO:0045216 25 17 1,000 2,186E-03 0,04189284 ! cell cycle checkpoint GO:0000075 108 64 2,000 2,331E-03 0,04431082 ! negative regulation of cell size GO:0045792 108 64 2,000 2,331E-03 0,04394762 ! respiratory system development GO:0060541 100 64 2,000 2,331E-03 0,04359032 ! positive regulation of DNA replication GO:0045740 29 18 1,000 2,452E-03 0,04548791 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,452E-03 0,04512401 ! pigmentation during development GO:0048066 31 18 1,000 2,452E-03 0,04476588 ! somitogenesis GO:0001756 24 18 1,000 2,452E-03 0,04441339 ! cellular response to nutrient levels GO:0031669 27 18 1,000 2,452E-03 0,04406641 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 2,452E-03 0,04372481 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,734E-03 0,04836414 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,734E-03 0,04799495 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 2,734E-03 0,04763135 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 2,734E-03 0,04727322 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 2,734E-03 0,04692043 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 2,734E-03 0,04657288 ! response to starvation GO:0042594 30 19 1,000 2,734E-03 0,04623043 ! sex determination GO:0007530 29 19 1,000 2,734E-03 0,04589298 ! DNA modification GO:0006304 28 20 1,000 3,029E-03 0,05048822 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 3,029E-03 0,05012499 ! positive regulation of B cell activation GO:0050871 31 20 1,000 3,029E-03 0,04976696 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 3,339E-03 0,05447044 ! protein amino acid acylation GO:0043543 37 21 1,000 3,339E-03 0,05408684 ! cell aging GO:0007569 32 21 1,000 3,339E-03 0,05370861 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 3,339E-03 0,05333564 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 3,339E-03 0,0529678 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 3,339E-03 0,05260501 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 3,522E-03 0,05510726 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 3,663E-03 0,056932 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 3,663E-03 0,05654991 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 4,002E-03 0,06135942 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 4,002E-03 0,06095307 ! negative regulation of DNA replication GO:0008156 35 23 1,000 4,002E-03 0,06055206 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 4,002E-03 0,0601563 ! interaction with host GO:0051701 37 23 1,000 4,002E-03 0,05976567 ! cellular response to oxidative stress GO:0034599 33 23 1,000 4,002E-03 0,05938009 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 4,002E-03 0,05899945 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 4,354E-03 0,0637834 ! mitochondrial membrane organization GO:0007006 39 24 1,000 4,354E-03 0,0633797 ! negative regulation of cell development GO:0010721 56 24 1,000 4,354E-03 0,06298109 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 4,354E-03 0,06258746 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 4,354E-03 0,06219872 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 4,72E-03 0,06701175 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 4,72E-03 0,06660064 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of pH GO:0006885 36 26 1,000 5,1E-03 0,0715206 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 5,1E-03 0,07108714 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 5,196E-03 0,07199685 ! cell cycle arrest GO:0007050 150 86 2,000 5,368E-03 0,07393577 ! response to ionizing radiation GO:0010212 47 27 1,000 5,493E-03 0,07520326 ! protein processing GO:0016485 114 88 2,000 5,723E-03 0,07788376 ! cell junction assembly GO:0034329 56 28 1,000 5,9E-03 0,07982323 ! cholesterol homeostasis GO:0042632 46 28 1,000 5,9E-03 0,07935643 GO:0055092|sterol homeostasis, ! complement activation, classical pathway GO:0006958 36 28 1,000 5,9E-03 0,07889505 ! neural tube formation GO:0001841 41 28 1,000 5,9E-03 0,07843901 ! positive regulation of catabolic process GO:0009896 40 28 1,000 5,9E-03 0,07798821 ! regulation of B cell activation GO:0050864 42 28 1,000 5,9E-03 0,07754257 ! cell fate commitment GO:0045165 141 92 2,000 6,473E-03 0,08458876 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 6,754E-03 0,0877604 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 6,754E-03 0,08726736 ! mammary gland development GO:0030879 57 31 1,000 7,2E-03 0,09251904 ! segmentation GO:0035282 41 31 1,000 7,2E-03 0,09200505 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 7,2E-03 0,09149673 ! cell fate specification GO:0001708 37 31 1,000 7,2E-03 0,090994 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 7,279E-03 0,09148482 ! protein maturation GO:0051604 129 96 2,000 7,279E-03 0,09098762 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 7,66E-03 0,09523358 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 7,66E-03 0,09472157 ! calcium-mediated signaling GO:0019722 50 32 1,000 7,66E-03 0,09421504 ! cytokine production GO:0001816 44 32 1,000 7,66E-03 0,09371389 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 7,66E-03 0,09321805 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 8,133E-03 0,09844865 ! cell junction organization GO:0034330 63 33 1,000 8,133E-03 0,09793322 ! carbohydrate homeostasis GO:0033500 39 33 1,000 8,133E-03 0,09742315 GO:0042593|glucose homeostasis, ! lipid homeostasis GO:0055088 55 33 1,000 8,133E-03 0,09691836 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 8,133E-03 0,09641878 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 8,618E-03 0,10164999 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 9,116E-03 0,1069769 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 9,627E-03 0,11239676 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 9,627E-03 0,1118291 ! neural tube development GO:0021915 50 36 1,000 9,627E-03 0,11126714 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,01015025 0,11672782 GO:0006956|complement activation, ! pigmentation GO:0043473 74 38 1,000 0,01068584 0,12227579 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,0112337 0,12790851 ! cell growth GO:0016049 61 39 1,000 0,0112337 0,12727842 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,01179373 0,1329685 ! T cell differentiation GO:0030217 65 40 1,000 0,01179373 0,13231987 ! double-strand break repair GO:0006302 67 40 1,000 0,01179373 0,13167754 ! B cell differentiation GO:0030183 62 40 1,000 0,01179373 0,13104142 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01236581 0,13673728 ! biopolymer methylation GO:0043414 62 41 1,000 0,01236581 0,13608304 ! mitochondrial transport GO:0006839 60 42 1,000 0,01294983 0,14183151 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01294983 0,14115932 ! regulation of cell shape GO:0008360 78 42 1,000 0,01294983 0,14049348 ! positive regulation of binding GO:0051099 59 43 1,000 0,0135457 0,14626816 ! activation of caspase activity GO:0006919 65 43 1,000 0,0135457 0,14558467 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,0135457 0,14490753 ! methylation GO:0032259 64 43 1,000 0,0135457 0,14423666 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,01415331 0,15001207 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01415331 0,14932394 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,01477256 0,15514557 ! positive regulation of defense response GO:0031349 59 45 1,000 0,01477256 0,15444036 ! histone modification GO:0016570 68 46 1,000 0,01540333 0,16030616 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01604553 0,16623752 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01604553 0,16549206 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01604553 0,16475326 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01669906 0,17070155 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 0,01669906 0,16994623 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,01669906 0,16919757 GO:0019724|B cell mediated immunity, ! lipid modification GO:0030258 73 50 1,000 0,0180397 0,18197942 ! positive regulation of growth GO:0045927 67 50 1,000 0,0180397 0,18118475 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,0180397 0,18039699 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,0187266 0,18645535 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01942443 0,19256978 ! aging GO:0007568 79 52 1,000 0,01942443 0,1917433 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,01942443 0,19092388 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,020426 0,19991406 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,020426 0,19906697 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,020426 0,19822703 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,020426 0,19739414 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,020426 0,19656822 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,020426 0,19574919 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,020426 0,19493695 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,020426 0,19413143 ! sleep GO:0030431 11 5 0,000 0,020426 0,19333253 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,020426 0,19254018 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,020426 0,19175431 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,020426 0,19097482 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,020426 0,19020164 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,020426 0,1894347 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,020426 0,18867392 ! tongue development GO:0043586 6 5 0,000 0,020426 0,18791922 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,020426 0,18717054 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,020426 0,1864278 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,020426 0,18569093 ! cobalt ion transport GO:0006824 9 5 0,000 0,020426 0,18495986 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,020426 0,18423453 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,020426 0,18351486 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,020426 0,1828008 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,020426 0,18209227 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,020426 0,18138921 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,020426 0,18069156 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,020426 0,17999925 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,020426 0,17931223 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,020426 0,17863044 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,020426 0,17795381 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,020426 0,17728228 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,020426 0,17661581 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,020426 0,17595433 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,020426 0,17529778 ! malate metabolic process GO:0006108 7 5 0,000 0,020426 0,17464612 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,020426 0,17399928 ! behavioral response to pain GO:0048266 7 5 0,000 0,020426 0,17335721 ! clathrin coat assembly GO:0048268 11 5 0,000 0,020426 0,17271987 ! phototransduction, visible light GO:0007603 6 5 0,000 0,020426 0,1720872 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,020426 0,17145914 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,020426 0,17083565 ! mating behavior GO:0007617 6 5 0,000 0,020426 0,17021668 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,020426 0,16960218 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,020426 0,1689921 ! rhythmic behavior GO:0007622 12 5 0,000 0,020426 0,1683864 ! copulation GO:0007620 7 5 0,000 0,020426 0,16778502 ! glial cell fate commitment GO:0021781 12 5 0,000 0,020426 0,16718792 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,020426 0,16659505 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,020426 0,16600638 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,020426 0,16542185 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,020426 0,16484142 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,020426 0,16426505 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,020426 0,1636927 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,020426 0,16312432 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,020426 0,16255988 ! response to protozoan GO:0001562 9 5 0,000 0,020426 0,16199933 ! lymph vessel development GO:0001945 7 5 0,000 0,020426 0,16144263 ! endochondral ossification GO:0001958 12 5 0,000 0,020426 0,16088974 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,020426 0,16034063 ! parathyroid gland development GO:0060017 8 5 0,000 0,020426 0,15979525 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,020426 0,15925358 ! anagen GO:0042640 6 5 0,000 0,020426 0,15871556 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,020426 0,15818116 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,020426 0,15765035 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,020426 0,15712309 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,020426 0,15659935 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,020426 0,15607909 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,020426 0,15556227 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,020426 0,15504886 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,020426 0,15453883 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,020426 0,15403215 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,020426 0,15352877 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,020426 0,15302868 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,020426 0,15253183 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,020426 0,1520382 ! ovulation GO:0030728 6 5 0,000 0,020426 0,15154776 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,020426 0,15106047 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,020426 0,1505763 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,020426 0,15009522 ! response to pH GO:0009268 9 5 0,000 0,020426 0,14961721 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,020426 0,14914224 ! proline biosynthetic process GO:0006561 6 5 0,000 0,020426 0,14867027 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,020426 0,14820128 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,020426 0,14773524 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,020426 0,14727212 ! polyol catabolic process GO:0046174 7 5 0,000 0,020426 0,14681189 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,020426 0,14635453 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,020426 0,14590002 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,020426 0,14544831 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,020426 0,1449994 ! nerve growth factor processing GO:0032455 7 5 0,000 0,020426 0,14455325 ! urea metabolic process GO:0019627 6 5 0,000 0,020426 0,14410983 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,020426 0,14366913 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,020426 0,14323111 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,020426 0,14279576 ! neutrophil activation GO:0042119 5 5 0,000 0,020426 0,14236305 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,020426 0,14193295 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,020426 0,14150544 ! response to food GO:0032094 5 5 0,000 0,020426 0,1410805 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,020426 0,1406581 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,020426 0,14023822 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,020426 0,13982085 ! forebrain neuron development GO:0021884 7 5 0,000 0,020426 0,13940595 ! melanosome organization GO:0032438 7 5 0,000 0,020426 0,13899351 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,020426 0,1385835 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,020426 0,1381759 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,020426 0,13777069 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,020426 0,13736785 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,020426 0,13696736 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,020426 0,1365692 ! nucleoside transport GO:0015858 6 5 0,000 0,020426 0,13617335 ! nucleoside salvage GO:0043174 7 5 0,000 0,020426 0,13577978 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,020426 0,13538849 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,020426 0,13499944 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,020426 0,13461262 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,020426 0,13422801 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,020426 0,1338456 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,020426 0,13346536 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,020426 0,13308727 ! depyrimidination GO:0045008 8 5 0,000 0,020426 0,13271131 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,020426 0,13233748 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,020426 0,13196574 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,020426 0,13159609 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,020426 0,13122851 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,020426 0,13086297 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,020426 0,13049946 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,020426 0,13013796 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,020426 0,12977847 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,020426 0,12942095 ! monocyte differentiation GO:0030224 8 5 0,000 0,020426 0,1290654 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,020426 0,12871179 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,020426 0,12836012 ! centrosome duplication GO:0051298 5 5 0,000 0,020426 0,12801037 ! response to UV-C GO:0010225 6 5 0,000 0,020426 0,12766251 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,020426 0,12731654 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,020426 0,12697245 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,020426 0,1266302 ! regulation of dendrite development GO:0050773 12 5 0,000 0,020426 0,1262898 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,020426 0,12595122 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,020426 0,12561445 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,020426 0,12527948 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,020426 0,12494629 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,020426 0,12461487 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,020426 0,1242852 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,020426 0,12395727 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,020426 0,12363107 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,020426 0,12330657 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,020426 0,12298378 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,020426 0,12266268 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,020426 0,12234324 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,020426 0,12202547 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,020426 0,12170934 ! neural tube patterning GO:0021532 6 5 0,000 0,020426 0,12139484 ! histone demethylation GO:0016577 9 5 0,000 0,020426 0,12108197 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,020426 0,12077071 ! regulation of sterol transport GO:0032371 7 5 0,000 0,020426 0,12046104 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,020426 0,12015295 ! enteric nervous system development GO:0048484 8 5 0,000 0,020426 0,11984644 ! establishment of planar polarity GO:0001736 6 5 0,000 0,020426 0,11954149 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,020426 0,11923808 ! muscle cell proliferation GO:0033002 8 5 0,000 0,020426 0,11893622 ! transcription termination GO:0006353 8 5 0,000 0,020426 0,11863587 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,020426 0,11833704 ! plasminogen activation GO:0031639 5 5 0,000 0,020426 0,11803971 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,020426 0,11774387 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,020426 0,11744951 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,020426 0,11715662 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,020426 0,11686519 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,020426 0,1165752 ! apical protein localization GO:0045176 6 5 0,000 0,020426 0,11628665 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,020426 0,11599952 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,020426 0,11571381 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,020426 0,1154295 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,020426 0,11514658 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,020426 0,11486505 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,020426 0,11458489 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,020426 0,11430609 ! glial cell migration GO:0008347 10 5 0,000 0,020426 0,11402865 ! determination of adult lifespan GO:0008340 8 5 0,000 0,020426 0,11375255 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,020426 0,11347779 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,020426 0,11320435 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,020426 0,11293222 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,020426 0,1126614 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,020426 0,11239188 ! neural plate development GO:0001840 6 5 0,000 0,020426 0,11212364 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,020426 0,11185668 ! regulation of sensory perception GO:0051931 6 5 0,000 0,020426 0,11159099 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,020426 0,11132655 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,020426 0,11106337 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,020426 0,11080143 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,020426 0,11054072 ! sensory cilium assembly GO:0035058 6 5 0,000 0,020426 0,11028123 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,020426 0,11002296 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,020426 0,1097659 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,020426 0,10951003 ! spindle assembly GO:0051225 5 5 0,000 0,020426 0,10925536 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,020426 0,10900187 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,020426 0,10874955 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,020426 0,10849839 ! organ regeneration GO:0031100 7 5 0,000 0,020426 0,1082484 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,020426 0,10799955 ! carnitine metabolic process GO:0009437 5 5 0,000 0,020426 0,10775185 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,020426 0,10750527 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,020426 0,10725983 GO:0055081|anion homeostasis, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,02085246 0,10924981 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,02085246 0,10900151 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,02085246 0,10875434 ! viral reproductive process GO:0022415 87 58 1,000 0,02383531 0,12402988 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,02383531 0,1237499 ! tRNA transcription GO:0009304 11 6 0,000 0,02446155 0,12671525 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02446155 0,1264305 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02446155 0,12614702 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02446155 0,12586482 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02446155 0,12558387 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02446155 0,12530417 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02446155 0,12502572 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02446155 0,1247485 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02446155 0,12447251 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02446155 0,12419773 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02446155 0,12392417 ! prostate gland development GO:0030850 9 6 0,000 0,02446155 0,12365181 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02446155 0,12338064 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02446155 0,12311066 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02446155 0,12284186 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02446155 0,12257423 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02446155 0,12230777 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02446155 0,12204246 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02446155 0,1217783 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02446155 0,12151528 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02446155 0,12125339 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02446155 0,12099263 ! neuron adhesion GO:0007158 9 6 0,000 0,02446155 0,12073299 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02446155 0,12047446 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02446155 0,12021704 ! signal peptide processing GO:0006465 8 6 0,000 0,02446155 0,11996071 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02446155 0,11970547 ! mRNA stabilization GO:0048255 15 6 0,000 0,02446155 0,11945132 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02446155 0,11919825 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02446155 0,11894624 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02446155 0,1186953 ! opsonization GO:0008228 8 6 0,000 0,02446155 0,11844542 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02446155 0,11819658 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02446155 0,11794879 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02446155 0,11770203 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02446155 0,11745631 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02446155 0,11721161 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02446155 0,11696793 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02446155 0,11672525 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02446155 0,11648359 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02446155 0,11624292 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02446155 0,11600324 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02446155 0,11576455 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02446155 0,11552684 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02446155 0,11529011 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02446155 0,11505434 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02446155 0,11481954 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02446155 0,11458569 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02446155 0,11435279 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02446155 0,11412084 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02446155 0,11388982 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02446155 0,11365974 ! thymic T cell selection GO:0045061 12 6 0,000 0,02446155 0,11343059 ! protein lipoylation GO:0009249 10 6 0,000 0,02446155 0,11320236 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02446155 0,11297505 ! pigment granule organization GO:0048753 11 6 0,000 0,02446155 0,11274864 ! drug transport GO:0015893 6 6 0,000 0,02446155 0,11252315 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02446155 0,11229855 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02446155 0,11207485 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02446155 0,11185203 ! histidine metabolic process GO:0006547 6 6 0,000 0,02446155 0,1116301 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02446155 0,11140905 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02446155 0,11118888 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02446155 0,11096957 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02446155 0,11075113 ! adenohypophysis development GO:0021984 10 6 0,000 0,02446155 0,11053354 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02446155 0,11031681 ! hyperosmotic response GO:0006972 8 6 0,000 0,02446155 0,11010092 ! microtubule nucleation GO:0007020 10 6 0,000 0,02446155 0,10988588 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02446155 0,10967168 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02446155 0,10945831 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02446155 0,10924577 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02446155 0,10903406 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02446155 0,10882316 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02446155 0,10861307 ! response to dietary excess GO:0002021 7 6 0,000 0,02446155 0,1084038 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02446155 0,10819533 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02446155 0,10798766 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02446155 0,10778079 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02446155 0,10757471 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02446155 0,10736941 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02446155 0,1071649 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02446155 0,10696116 ! neuron apoptosis GO:0051402 8 6 0,000 0,02446155 0,1067582 ! organic alcohol transport GO:0015850 9 6 0,000 0,02446155 0,10655601 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02446155 0,10635458 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02446155 0,10615391 ! carnitine transport GO:0015879 8 6 0,000 0,02446155 0,105954 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02446155 0,10575484 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02446155 0,10555642 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02446155 0,10535875 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02446155 0,10516182 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02446155 0,10496562 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02446155 0,10477015 ! parturition GO:0007567 12 6 0,000 0,02446155 0,10457541 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02446155 0,1043814 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02446155 0,1041881 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02446155 0,10399551 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02446155 0,10380364 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02446155 0,10361247 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02446155 0,10342201 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02446155 0,10323224 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02446155 0,10304317 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02446155 0,10285479 ! astrocyte development GO:0014002 14 6 0,000 0,02446155 0,1026671 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02446155 0,1024801 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02446155 0,10229377 ! interaction with symbiont GO:0051702 8 6 0,000 0,02446155 0,10210812 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02446155 0,10192314 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02446155 0,10173883 ! eating behavior GO:0042755 6 6 0,000 0,02446155 0,10155519 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02446155 0,1013722 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02446155 0,10118988 ! response to copper ion GO:0046688 9 6 0,000 0,02446155 0,10100821 ! DNA topological change GO:0006265 8 6 0,000 0,02446155 0,10082719 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02446155 0,10064682 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02446155 0,10046709 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02446155 0,10028801 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02446155 0,10010956 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02446155 0,09993175 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02446155 0,09975456 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02446155 0,099578 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02446155 0,09940207 ! gas homeostasis GO:0033483 11 6 0,000 0,02446155 0,09922676 ! hair follicle maturation GO:0048820 7 6 0,000 0,02446155 0,09905206 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02446155 0,09887798 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02446155 0,09870451 ! Schwann cell development GO:0014044 14 6 0,000 0,02446155 0,09853165 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02446155 0,09835939 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02446155 0,09818774 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02446155 0,09801668 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02446155 0,09784621 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02446155 0,09767634 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02446155 0,09750706 ! histone ubiquitination GO:0016574 7 6 0,000 0,02446155 0,09733836 ! regulation of meiosis GO:0040020 10 6 0,000 0,02446155 0,09717025 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02446155 0,09700271 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02446155 0,09683575 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02446155 0,09666937 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02446155 0,09650356 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02446155 0,09633831 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02446155 0,09617363 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02446155 0,09600951 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02446155 0,09584595 ! receptor internalization GO:0031623 9 6 0,000 0,02446155 0,09568295 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02446155 0,0955205 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02446155 0,0953586 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02446155 0,09519725 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02446155 0,09503644 ! protein deubiquitination GO:0016579 8 6 0,000 0,02446155 0,09487618 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02446155 0,09471645 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02446155 0,09455726 ! axonal fasciculation GO:0007413 9 6 0,000 0,02446155 0,09439861 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02446155 0,09424049 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02446155 0,0940829 ! midbrain development GO:0030901 6 6 0,000 0,02446155 0,09392583 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02446155 0,09376929 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02446155 0,09361327 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02446155 0,09345776 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02446155 0,09330277 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02446155 0,0931483 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02446155 0,09299433 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02446155 0,09284088 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02446155 0,09268793 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02446155 0,09253548 ! adult feeding behavior GO:0008343 6 6 0,000 0,02446155 0,09238353 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02446155 0,09223209 ! blastocyst growth GO:0001832 15 6 0,000 0,02446155 0,09208113 ! pigment granule transport GO:0051904 12 6 0,000 0,02446155 0,09193067 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02446155 0,09178071 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02446155 0,09163123 ! catecholamine transport GO:0051937 7 6 0,000 0,02446155 0,09148223 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02446155 0,09133372 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02446155 0,09118569 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02446155 0,09103814 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02446155 0,09089107 ! protein prenylation GO:0018342 10 6 0,000 0,02446155 0,09074447 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02446155 0,09059835 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02446155 0,09045269 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02446155 0,0903075 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02446155 0,09016278 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02446155 0,09001852 ! activation of MAPK activity GO:0000187 84 59 1,000 0,02460687 0,09040862 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,02538858 0,09313195 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,02538858 0,09298365 GO:0035113|embryonic appendage morphogenesis, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,02618034 0,09573099 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,02698207 0,09850598 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,02698207 0,09834987 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,02779367 0,10114784 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,02779367 0,10098805 ! viral reproduction GO:0016032 92 63 1,000 0,02779367 0,10082876 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02779367 0,10066998 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02848071 0,10299628 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02848071 0,10283459 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02848071 0,1026734 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02848071 0,10251272 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02848071 0,10235255 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02848071 0,10219287 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02848071 0,10203369 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02848071 0,10187501 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02848071 0,10171682 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02848071 0,10155912 ! reproductive behavior GO:0019098 12 7 0,000 0,02848071 0,10140191 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02848071 0,10124518 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02848071 0,10108894 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02848071 0,10093318 ! oligopeptide transport GO:0006857 11 7 0,000 0,02848071 0,10077789 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02848071 0,10062309 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02848071 0,10046876 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02848071 0,1003149 ! RNA methylation GO:0001510 11 7 0,000 0,02848071 0,10016152 ! pericardium development GO:0060039 8 7 0,000 0,02848071 0,1000086 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02848071 0,09985615 ! fibril organization GO:0043206 13 7 0,000 0,02848071 0,09970416 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02848071 0,09955263 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02848071 0,09940156 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02848071 0,09925096 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02848071 0,0991008 ! lipoprotein transport GO:0042953 9 7 0,000 0,02848071 0,0989511 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02848071 0,09880186 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02848071 0,09865306 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02848071 0,09850471 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02848071 0,0983568 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02848071 0,09820934 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02848071 0,09806232 ! chemosensory behavior GO:0007635 9 7 0,000 0,02848071 0,09791574 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02848071 0,0977696 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02848071 0,09762389 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02848071 0,09747862 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02848071 0,09733378 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02848071 0,09718936 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02848071 0,09704538 ! reflex GO:0060004 12 7 0,000 0,02848071 0,09690182 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02848071 0,09675869 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02848071 0,09661598 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02848071 0,09647368 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02848071 0,09633181 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02848071 0,09619035 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02848071 0,09604931 ! spinal cord patterning GO:0021511 7 7 0,000 0,02848071 0,09590868 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02848071 0,09576847 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02848071 0,09562866 ! adrenal gland development GO:0030325 17 7 0,000 0,02848071 0,09548926 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02848071 0,09535026 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02848071 0,09521167 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02848071 0,09507349 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02848071 0,0949357 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02848071 0,09479831 ! endosome organization GO:0007032 10 7 0,000 0,02848071 0,09466132 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02848071 0,09452472 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02848071 0,09438852 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02848071 0,09425271 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02848071 0,09411729 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02848071 0,09398225 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02848071 0,09384761 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02848071 0,09371335 ! galactose metabolic process GO:0006012 10 7 0,000 0,02848071 0,09357947 ! vesicle fusion GO:0006906 15 7 0,000 0,02848071 0,09344598 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02848071 0,09331286 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02848071 0,09318013 ! organ growth GO:0035265 11 7 0,000 0,02848071 0,09304777 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02848071 0,09291579 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02848071 0,09278418 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02848071 0,09265294 ! retinol metabolic process GO:0042572 9 7 0,000 0,02848071 0,09252208 ! behavioral fear response GO:0001662 13 7 0,000 0,02848071 0,09239158 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02848071 0,09226145 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02848071 0,09213169 ! rRNA modification GO:0000154 12 7 0,000 0,02848071 0,09200229 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02848071 0,09187326 ! response to UV-B GO:0010224 11 7 0,000 0,02848071 0,09174458 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02848071 0,09161627 ! intermediate filament organization GO:0045109 11 7 0,000 0,02848071 0,09148831 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02848071 0,09136071 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02848071 0,09123347 ! fibrinolysis GO:0042730 9 7 0,000 0,02848071 0,09110658 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02848071 0,09098004 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02848071 0,09085386 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02848071 0,09072802 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02848071 0,09060253 ! response to tropane GO:0014073 13 7 0,000 0,02848071 0,09047739 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02848071 0,09035259 ! melanosome localization GO:0032400 10 7 0,000 0,02848071 0,09022814 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02848071 0,09010403 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02848071 0,08998026 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02848071 0,08985683 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02848071 0,08973374 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02848071 0,08961099 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02848071 0,08948857 ! mast cell activation GO:0045576 9 7 0,000 0,02848071 0,08936648 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02848071 0,08924473 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02848071 0,08912331 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02848071 0,08900222 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02848071 0,08888145 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02848071 0,08876102 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02848071 0,08864091 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02848071 0,08852112 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02848071 0,08840166 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02848071 0,08828252 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02848071 0,0881637 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02848071 0,0880452 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02848071 0,08792702 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02848071 0,08780916 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02848071 0,08769161 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02848071 0,08757437 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02848071 0,08745745 ! diuresis GO:0030146 12 7 0,000 0,02848071 0,08734084 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02848071 0,08722454 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02848071 0,08710855 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02848071 0,08699287 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02848071 0,08687749 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02848071 0,08676243 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02848071 0,08664766 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02848071 0,0865332 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02848071 0,08641904 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02848071 0,08630518 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02848071 0,08619162 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02848071 0,08607836 ! lymph node development GO:0048535 9 7 0,000 0,02848071 0,0859654 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02848071 0,08585273 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02848071 0,08574035 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02848071 0,08562828 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02848071 0,08551649 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02848071 0,085405 ! ATP catabolic process GO:0006200 10 7 0,000 0,02848071 0,08529379 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02848071 0,08518288 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02848071 0,08507225 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02848071 0,08496191 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02848071 0,08485185 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02848071 0,08474208 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02848071 0,0846326 ! muscle adaptation GO:0043500 12 7 0,000 0,02848071 0,0845234 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02848071 0,08441447 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02848071 0,08430583 ! retina homeostasis GO:0001895 9 7 0,000 0,02848071 0,08419747 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02848071 0,08408939 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02848071 0,08398158 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02848071 0,08387405 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02848071 0,08376679 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02848071 0,08365981 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02848071 0,0835531 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02848071 0,08344666 ! appendage morphogenesis GO:0035107 93 64 1,000 0,02861504 0,08373358 GO:0035108|limb morphogenesis, ! adaptive immune response GO:0002250 94 64 1,000 0,02861504 0,08362718 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of caspase activity GO:0043281 97 65 1,000 0,0294461 0,08594673 ! appendage development GO:0048736 94 65 1,000 0,0294461 0,0858378 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,0294461 0,08572914 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,0294461 0,08562076 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,0294461 0,08551265 ! activation of immune response GO:0002253 83 65 1,000 0,0294461 0,08540482 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,0311369 0,09019504 ! acute inflammatory response GO:0002526 92 68 1,000 0,03199646 0,09256838 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03248354 0,09385946 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03248354 0,0937417 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03248354 0,09362423 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03248354 0,09350705 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03248354 0,09339016 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03248354 0,09327357 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03248354 0,09315727 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03248354 0,09304126 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03248354 0,09292554 ! phosphate transport GO:0006817 10 8 0,000 0,03248354 0,0928101 ! N-glycan processing GO:0006491 12 8 0,000 0,03248354 0,09269495 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03248354 0,09258009 ! UTP metabolic process GO:0046051 8 8 0,000 0,03248354 0,09246551 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03248354 0,09235121 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03248354 0,0922372 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03248354 0,09212347 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03248354 0,09201001 ! succinate metabolic process GO:0006105 14 8 0,000 0,03248354 0,09189684 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,03248354 0,09178395 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03248354 0,09167133 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03248354 0,09155898 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03248354 0,09144692 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03248354 0,09133512 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03248354 0,0912236 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03248354 0,09111236 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03248354 0,09100138 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03248354 0,09089067 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03248354 0,09078023 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03248354 0,09067006 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03248354 0,09056016 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03248354 0,09045052 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03248354 0,09034115 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03248354 0,09023204 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03248354 0,0901232 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03248354 0,09001462 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03248354 0,0899063 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03248354 0,08979824 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03248354 0,08969043 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03248354 0,08958289 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03248354 0,08947561 ! melanin metabolic process GO:0006582 12 8 0,000 0,03248354 0,08936858 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03248354 0,08926181 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03248354 0,08915529 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03248354 0,08904902 ! macrophage activation GO:0042116 12 8 0,000 0,03248354 0,08894301 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03248354 0,08883726 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03248354 0,08873175 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03248354 0,08862649 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03248354 0,08852148 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03248354 0,08841672 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03248354 0,08831221 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03248354 0,08820795 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03248354 0,08810393 ! ruffle organization GO:0031529 11 8 0,000 0,03248354 0,08800015 ! osteoblast development GO:0002076 13 8 0,000 0,03248354 0,08789663 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03248354 0,08779334 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03248354 0,0876903 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03248354 0,08758749 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03248354 0,08748493 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03248354 0,08738261 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03248354 0,08728053 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03248354 0,08717868 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03248354 0,08707708 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03248354 0,08697571 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03248354 0,08687457 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03248354 0,08677367 ! segment specification GO:0007379 10 8 0,000 0,03248354 0,08667301 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03248354 0,08657257 ! cellular extravasation GO:0045123 11 8 0,000 0,03248354 0,08647237 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03248354 0,08637241 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03248354 0,08627267 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03248354 0,08617316 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03248354 0,08607388 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03248354 0,08597483 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03248354 0,08587601 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03248354 0,08577742 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03248354 0,08567905 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03248354 0,08558091 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03248354 0,08548299 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03248354 0,08538529 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03248354 0,08528782 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03248354 0,08519057 ! icosanoid secretion GO:0032309 12 8 0,000 0,03248354 0,08509354 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03248354 0,08499674 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03248354 0,08490015 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03248354 0,08480378 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03248354 0,08470763 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03248354 0,0846117 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03248354 0,08451599 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03248354 0,08442049 ! sterol catabolic process GO:0016127 9 8 0,000 0,03248354 0,0843252 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03248354 0,08423014 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03248354 0,08413528 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03248354 0,08404064 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03248354 0,08394622 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03248354 0,083852 ! prophase GO:0051324 11 8 0,000 0,03248354 0,083758 ! S phase GO:0051320 8 8 0,000 0,03248354 0,0836642 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03248354 0,08357062 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03248354 0,08347724 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03248354 0,08338408 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03248354 0,08329112 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03248354 0,08319836 ! hormone catabolic process GO:0042447 13 8 0,000 0,03248354 0,08310582 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03248354 0,08301348 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03248354 0,08292134 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03248354 0,08282941 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03248354 0,08273769 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03248354 0,08264616 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03248354 0,08255484 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03248354 0,08246372 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03248354 0,0823728 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03248354 0,08228208 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03248354 0,08219156 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03248354 0,08210124 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03248354 0,08201112 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03248354 0,0819212 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03248354 0,08183147 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03248354 0,08174194 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,03286535 0,08261235 ! humoral immune response GO:0006959 86 70 1,000 0,03374347 0,08472705 ! eye development GO:0001654 111 70 1,000 0,03374347 0,08463465 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,03374347 0,08454245 ! regulation of catabolic process GO:0009894 106 70 1,000 0,03374347 0,08445046 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,03463073 0,08657683 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,03463073 0,08648283 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,03463073 0,08638903 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,03552705 0,08852895 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,03552705 0,08843314 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 0,03552705 0,08833754 ! tube morphogenesis GO:0035239 118 73 1,000 0,03643234 0,0904907 ! mitochondrion organization GO:0007005 104 73 1,000 0,03643234 0,09039309 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,03643234 0,09029568 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,0364701 0,09029195 ! telencephalon cell migration GO:0022029 16 9 0,000 0,0364701 0,09019486 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,0364701 0,09009799 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,0364701 0,09000131 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,0364701 0,08990485 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,0364701 0,08980859 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0364701 0,08971254 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,0364701 0,08961669 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,0364701 0,08952105 ! GTP metabolic process GO:0046039 9 9 0,000 0,0364701 0,08942561 ! elastic fiber assembly GO:0048251 13 9 0,000 0,0364701 0,08933038 ! social behavior GO:0035176 14 9 0,000 0,0364701 0,08923535 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,0364701 0,08914051 ! artery development GO:0060840 19 9 0,000 0,0364701 0,08904589 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,0364701 0,08895146 ! response to pain GO:0048265 16 9 0,000 0,0364701 0,08885723 ! protein complex disassembly GO:0043241 17 9 0,000 0,0364701 0,0887632 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,0364701 0,08866937 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,0364701 0,08857574 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,0364701 0,0884823 ! lung alveolus development GO:0048286 17 9 0,000 0,0364701 0,08838907 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,0364701 0,08829603 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,0364701 0,08820318 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,0364701 0,08811053 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,0364701 0,08801807 ! ventral spinal cord development GO:0021517 11 9 0,000 0,0364701 0,08792581 ! protein targeting to ER GO:0045047 19 9 0,000 0,0364701 0,08783374 ! T cell selection GO:0045058 18 9 0,000 0,0364701 0,08774187 ! endoderm development GO:0007492 12 9 0,000 0,0364701 0,08765018 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,0364701 0,08755869 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,0364701 0,08746739 ! arginine catabolic process GO:0006527 10 9 0,000 0,0364701 0,08737628 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,0364701 0,08728535 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,0364701 0,08719462 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,0364701 0,08710408 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,0364701 0,08701372 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,0364701 0,08692355 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,0364701 0,08683357 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,0364701 0,08674377 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,0364701 0,08665416 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0364701 0,08656473 ! mannose metabolic process GO:0006013 9 9 0,000 0,0364701 0,08647549 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,0364701 0,08638643 ! receptor clustering GO:0043113 15 9 0,000 0,0364701 0,08629756 ! epithelial cell development GO:0002064 10 9 0,000 0,0364701 0,08620886 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,0364701 0,08612035 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,0364701 0,08603202 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,0364701 0,08594388 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,0364701 0,08585591 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,0364701 0,08576812 ! motor axon guidance GO:0008045 14 9 0,000 0,0364701 0,08568052 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,0364701 0,08559309 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,0364701 0,08550584 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,0364701 0,08541876 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,0364701 0,08533187 ! blastoderm segmentation GO:0007350 11 9 0,000 0,0364701 0,08524515 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,0364701 0,0851586 ! DNA ligation GO:0006266 14 9 0,000 0,0364701 0,08507224 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,0364701 0,08498604 ! response to amine stimulus GO:0014075 13 9 0,000 0,0364701 0,08490002 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,0364701 0,08481418 ! erythrocyte development GO:0048821 11 9 0,000 0,0364701 0,08472851 ! renal water homeostasis GO:0003091 14 9 0,000 0,0364701 0,08464301 ! postreplication repair GO:0006301 11 9 0,000 0,0364701 0,08455769 ! mRNA cleavage GO:0006379 13 9 0,000 0,0364701 0,08447253 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,0364701 0,08438755 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,0364701 0,08430274 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,0364701 0,0842181 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,0364701 0,08413363 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,0364701 0,08404932 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,0364701 0,08396519 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,0364701 0,08388122 ! acid secretion GO:0046717 14 9 0,000 0,0364701 0,08379743 ! musculoskeletal movement GO:0050881 11 9 0,000 0,0364701 0,0837138 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,0364701 0,08363033 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,0364701 0,08354704 ! purine base metabolic process GO:0006144 18 9 0,000 0,0364701 0,0834639 ! oocyte differentiation GO:0009994 12 9 0,000 0,0364701 0,08338094 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,0364701 0,08329814 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,0364701 0,0832155 ! spleen development GO:0048536 15 9 0,000 0,0364701 0,08313303 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,0364701 0,08305072 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,0364701 0,08296857 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,0364701 0,08288659 ! detection of calcium ion GO:0005513 13 9 0,000 0,0364701 0,08280476 ! blastocyst formation GO:0001825 12 9 0,000 0,0364701 0,0827231 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,0364701 0,0826416 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,0364701 0,08256026 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,0364701 0,08247908 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,0364701 0,08239806 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0364701 0,0823172 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,0364701 0,08223649 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,0364701 0,08215595 ! prepulse inhibition GO:0060134 14 9 0,000 0,0364701 0,08207556 ! embryonic placenta development GO:0001892 12 9 0,000 0,0364701 0,08199533 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,0364701 0,08191526 ! insulin secretion GO:0030073 17 9 0,000 0,0364701 0,08183534 ! sequestering of metal ion GO:0051238 11 9 0,000 0,0364701 0,08175558 ! response to nicotine GO:0035094 16 9 0,000 0,0364701 0,08167597 ! establishment of cell polarity GO:0030010 12 9 0,000 0,0364701 0,08159652 ! regulation of synapse organization GO:0050807 12 9 0,000 0,0364701 0,08151722 ! response to oxygen levels GO:0070482 137 74 1,000 0,03734652 0,08339514 ! protein import into nucleus GO:0006606 118 74 1,000 0,03734652 0,08331425 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03734652 0,08323352 ! regulation of ligase activity GO:0051340 114 75 1,000 0,03826949 0,08520796 ! nuclear import GO:0051170 121 75 1,000 0,03826949 0,08512556 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,03920117 0,08711371 ! regulation of DNA binding GO:0051101 119 77 1,000 0,04014148 0,08911718 ! gland development GO:0048732 148 77 1,000 0,04014148 0,08903124 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,04014148 0,08894547 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04044046 0,08952171 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04044046 0,08943563 ! neuron fate specification GO:0048665 11 10 0,000 0,04044046 0,08934972 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04044046 0,08926397 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04044046 0,08917839 ! thyroid gland development GO:0030878 19 10 0,000 0,04044046 0,08909297 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04044046 0,08900771 ! synapsis GO:0007129 13 10 0,000 0,04044046 0,08892262 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04044046 0,08883769 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04044046 0,08875292 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04044046 0,08866831 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04044046 0,08858387 ! sulfate transport GO:0008272 12 10 0,000 0,04044046 0,08849958 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04044046 0,08841546 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,04044046 0,08833149 ! phospholipid efflux GO:0033700 16 10 0,000 0,04044046 0,08824768 ! hippocampus development GO:0021766 19 10 0,000 0,04044046 0,08816404 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,04044046 0,08808055 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04044046 0,08799722 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04044046 0,08791404 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04044046 0,08783103 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04044046 0,08774817 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04044046 0,08766547 ! pathogenesis GO:0009405 13 10 0,000 0,04044046 0,08758292 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04044046 0,08750053 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04044046 0,08741829 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04044046 0,08733621 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04044046 0,08725428 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04044046 0,0871725 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04044046 0,08709088 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04044046 0,08700941 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04044046 0,08692809 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04044046 0,08684693 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04044046 0,08676591 ! B cell proliferation GO:0042100 14 10 0,000 0,04044046 0,08668505 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04044046 0,08660434 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04044046 0,08652378 ! forebrain cell migration GO:0021885 17 10 0,000 0,04044046 0,08644336 ! lipid digestion GO:0044241 15 10 0,000 0,04044046 0,0863631 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04044046 0,08628299 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04044046 0,08620302 ! UV protection GO:0009650 14 10 0,000 0,04044046 0,0861232 ! entry into host cell GO:0030260 20 10 0,000 0,04044046 0,08604353 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04044046 0,08596401 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04044046 0,08588463 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04044046 0,08580541 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04044046 0,08572632 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04044046 0,08564738 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04044046 0,08556859 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04044046 0,08548994 ! regulation of organ growth GO:0046620 11 10 0,000 0,04044046 0,08541144 ! response to dsRNA GO:0043331 18 10 0,000 0,04044046 0,08533308 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04044046 0,08525487 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04044046 0,08517679 ! embryonic axis specification GO:0000578 12 10 0,000 0,04044046 0,08509886 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04044046 0,08502108 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04044046 0,08494343 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04044046 0,08486593 ! cranial nerve development GO:0021545 12 10 0,000 0,04044046 0,08478857 ! fucose catabolic process GO:0019317 16 10 0,000 0,04044046 0,08471135 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04044046 0,08463427 ! protein sumoylation GO:0016925 12 10 0,000 0,04044046 0,08455733 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04044046 0,08448053 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04044046 0,08440387 ! zymogen activation GO:0031638 14 10 0,000 0,04044046 0,08432734 ! salivary gland development GO:0007431 22 10 0,000 0,04044046 0,08425096 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04044046 0,08417471 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04044046 0,08409861 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04044046 0,08402264 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04044046 0,0839468 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04044046 0,08387111 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04044046 0,08379555 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04044046 0,08372013 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04044046 0,08364484 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04044046 0,08356968 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04044046 0,08349467 ! detection of bacterium GO:0016045 10 10 0,000 0,04044046 0,08341978 ! embryonic gut development GO:0048566 11 10 0,000 0,04044046 0,08334504 ! activation of innate immune response GO:0002218 10 10 0,000 0,04044046 0,08327042 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04044046 0,08319594 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04044046 0,08312159 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04044046 0,08304737 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04044046 0,08297329 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04044046 0,08289934 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04044046 0,08282552 ! T cell activation GO:0042110 134 79 1,000 0,04204763 0,08604053 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,04301331 0,08793832 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,04301331 0,08786022 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,04398728 0,08976995 GO:0002696|positive regulation of leukocyte activation, ! rRNA transcription GO:0009303 17 11 0,000 0,04439469 0,09052109 ! respiratory burst GO:0045730 14 11 0,000 0,04439469 0,09044091 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04439469 0,09036087 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04439469 0,09028098 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04439469 0,09020122 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,04439469 0,09012161 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04439469 0,09004214 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04439469 0,08996281 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,04439469 0,08988361 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04439469 0,08980456 ! mating GO:0007618 14 11 0,000 0,04439469 0,08972565 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,04439469 0,08964687 ! T cell proliferation GO:0042098 20 11 0,000 0,04439469 0,08956823 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04439469 0,08948973 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04439469 0,08941137 ! bone resorption GO:0045453 16 11 0,000 0,04439469 0,08933315 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04439469 0,08925506 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04439469 0,08917711 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04439469 0,08909929 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04439469 0,08902161 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04439469 0,08894406 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04439469 0,08886665 ! syncytium formation GO:0006949 15 11 0,000 0,04439469 0,08878938 ! plasma membrane organization GO:0007009 18 11 0,000 0,04439469 0,08871224 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04439469 0,08863523 ! focal adhesion formation GO:0048041 24 11 0,000 0,04439469 0,08855836 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04439469 0,08848162 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04439469 0,08840501 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04439469 0,08832853 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04439469 0,08825219 ! adult heart development GO:0007512 11 11 0,000 0,04439469 0,08817598 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04439469 0,0880999 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,04439469 0,08802395 ! temperature homeostasis GO:0001659 16 11 0,000 0,04439469 0,08794814 ! L-glutamate transport GO:0015813 16 11 0,000 0,04439469 0,08787245 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04439469 0,08779689 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04439469 0,08772147 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04439469 0,08764617 ! stem cell development GO:0048864 29 11 0,000 0,04439469 0,087571 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04439469 0,08749596 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04439469 0,08742105 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04439469 0,08734627 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04439469 0,08727161 ! vasoconstriction GO:0042310 15 11 0,000 0,04439469 0,08719708 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04439469 0,08712268 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04439469 0,08704841 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04439469 0,08697426 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04439469 0,08690024 ! ribosome assembly GO:0042255 13 11 0,000 0,04439469 0,08682635 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04439469 0,08675258 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04439469 0,08667894 ! chromatin silencing GO:0006342 19 11 0,000 0,04439469 0,08660542 ! nucleosome positioning GO:0016584 13 11 0,000 0,04439469 0,08653202 ! T cell homeostasis GO:0043029 20 11 0,000 0,04439469 0,08645875 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04439469 0,08638561 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04439469 0,08631258 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04439469 0,08623968 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04439469 0,08616691 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04439469 0,08609425 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04439469 0,08602172 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04439469 0,08594931 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04439469 0,08587703 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04439469 0,08580486 ! male genitalia development GO:0030539 13 11 0,000 0,04439469 0,08573282 ! cholesterol efflux GO:0033344 19 11 0,000 0,04439469 0,08566089 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04439469 0,08558909 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04439469 0,08551741 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04439469 0,08544585 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04439469 0,0853744 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04439469 0,08530308 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04439469 0,08523187 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,04439469 0,08516079 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,04439469 0,08508982 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04439469 0,08501897 ! lysogeny GO:0030069 18 11 0,000 0,04439469 0,08494824 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04439469 0,08487763 ! acrosome reaction GO:0007340 13 11 0,000 0,04439469 0,08480713 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04439469 0,08473675 ! ossification GO:0001503 134 82 1,000 0,04496945 0,08576264 GO:0060348|bone development, ! regulation of defense response GO:0031347 117 84 1,000 0,0469581 0,08948105 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,04796441 0,09132296 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,04796441 0,09124743 ! lactation GO:0007595 20 12 0,000 0,04833285 0,09187236 ! reproductive cellular process GO:0048610 14 12 0,000 0,04833285 0,09179649 ! tRNA modification GO:0006400 14 12 0,000 0,04833285 0,09172075 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04833285 0,09164514 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04833285 0,09156965 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04833285 0,09149428 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04833285 0,09141904 ! non-recombinational repair GO:0000726 19 12 0,000 0,04833285 0,09134392 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04833285 0,09126893 ! peroxisomal transport GO:0043574 21 12 0,000 0,04833285 0,09119405 ! cartilage condensation GO:0001502 18 12 0,000 0,04833285 0,09111931 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04833285 0,09104468 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04833285 0,09097017 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04833285 0,09089579 ! heart looping GO:0001947 15 12 0,000 0,04833285 0,09082153 ! palate development GO:0060021 15 12 0,000 0,04833285 0,09074739 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04833285 0,09067337 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04833285 0,09059947 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04833285 0,09052569 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04833285 0,09045204 ! arginine metabolic process GO:0006525 13 12 0,000 0,04833285 0,0903785 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04833285 0,09030508 ! methionine metabolic process GO:0006555 13 12 0,000 0,04833285 0,09023178 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04833285 0,0901586 ! Golgi organization GO:0007030 18 12 0,000 0,04833285 0,09008554 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04833285 0,09001259 ! monoamine transport GO:0015844 13 12 0,000 0,04833285 0,08993977 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04833285 0,08986706 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04833285 0,08979447 ! L-amino acid transport GO:0015807 20 12 0,000 0,04833285 0,089722 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04833285 0,08964964 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04833285 0,0895774 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04833285 0,08950528 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04833285 0,08943327 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04833285 0,08936138 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04833285 0,0892896 ! cerebellum development GO:0021549 13 12 0,000 0,04833285 0,08921794 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04833285 0,08914639 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04833285 0,08907496 ! histone methylation GO:0016571 15 12 0,000 0,04833285 0,08900364 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04833285 0,08893244 ! gland morphogenesis GO:0022612 23 12 0,000 0,04833285 0,08886135 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04833285 0,08879038 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04833285 0,08871951 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04833285 0,08864877 ! intestinal absorption GO:0050892 19 12 0,000 0,04833285 0,08857813 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04833285 0,08850761 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04833285 0,08843719 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04833285 0,08836689 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04833285 0,08829671 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04833285 0,08822663 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04833285 0,08815666 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04833285 0,08808681 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04833285 0,08801706 ! response to cold GO:0009409 14 12 0,000 0,04833285 0,08794743 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,05000059 0,09091017 GO:0060538|skeletal muscle organ development, ! regulation of neurogenesis GO:0050767 153 89 1,000 0,05206767 0,09459372 ! reproductive developmental process GO:0003006 127 89 1,000 0,05206767 0,09451906 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,052255 0,09478431 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,052255 0,09470962 ! cGMP metabolic process GO:0046068 16 13 0,000 0,052255 0,09463504 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,052255 0,09456059 ! water transport GO:0006833 17 13 0,000 0,052255 0,09448625 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,052255 0,09441202 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,052255 0,09433792 ! lipid localization GO:0010876 24 13 0,000 0,052255 0,09426393 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,052255 0,09419005 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,052255 0,09411629 ! organelle fusion GO:0048284 28 13 0,000 0,052255 0,09404265 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,052255 0,09396912 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,052255 0,09389571 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,052255 0,09382241 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,052255 0,09374923 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,052255 0,09367616 ! response to hexose stimulus GO:0009746 19 13 0,000 0,052255 0,0936032 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,052255 0,09353036 ! glutamate metabolic process GO:0006536 18 13 0,000 0,052255 0,09345763 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,052255 0,09338501 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,052255 0,09331251 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,052255 0,09324011 ! NAD metabolic process GO:0019674 21 13 0,000 0,052255 0,09316783 ! exocrine system development GO:0035272 27 13 0,000 0,052255 0,09309567 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,052255 0,09302361 ! bone mineralization GO:0030282 15 13 0,000 0,052255 0,09295167 ! regulation of exocytosis GO:0017157 17 13 0,000 0,052255 0,09287984 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,052255 0,09280811 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,052255 0,0927365 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,052255 0,092665 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,052255 0,09259361 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,052255 0,09252233 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,052255 0,09245116 ! genitalia development GO:0048806 15 13 0,000 0,052255 0,0923801 ! cellular pigmentation GO:0033059 24 13 0,000 0,052255 0,09230915 ! tissue regeneration GO:0042246 21 13 0,000 0,052255 0,0922383 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,052255 0,09216757 ! cofactor transport GO:0051181 19 13 0,000 0,052255 0,09209694 ! NADP metabolic process GO:0006739 18 13 0,000 0,052255 0,09202642 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,052255 0,09195601 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,052255 0,09188571 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,052255 0,09181551 ! gas transport GO:0015669 18 13 0,000 0,052255 0,09174543 ! regulation of RNA stability GO:0043487 28 13 0,000 0,052255 0,09167544 ! heme biosynthetic process GO:0006783 20 13 0,000 0,052255 0,09160557 ! regulation of axon extension GO:0030516 23 13 0,000 0,052255 0,0915358 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,052255 0,09146614 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,052255 0,09139658 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,052255 0,09132713 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,052255 0,09125779 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,052255 0,09118855 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,052255 0,09111941 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,05522484 0,0962251 ! positive regulation of immune response GO:0050778 121 92 1,000 0,05522484 0,09615226 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05616122 0,09770862 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,05616122 0,09763477 ! superoxide anion generation GO:0042554 18 14 0,000 0,05616122 0,09756103 ! neuron maturation GO:0042551 21 14 0,000 0,05616122 0,09748739 ! regulation of S phase GO:0033261 18 14 0,000 0,05616122 0,09741387 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05616122 0,09734047 ! myotube differentiation GO:0014902 21 14 0,000 0,05616122 0,09726717 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,05616122 0,09719398 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05616122 0,0971209 ! inositol metabolic process GO:0006020 20 14 0,000 0,05616122 0,09704793 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05616122 0,09697507 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05616122 0,09690232 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05616122 0,09682968 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05616122 0,09675715 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05616122 0,09668473 ! response to cAMP GO:0051591 19 14 0,000 0,05616122 0,09661241 ! limbic system development GO:0021761 25 14 0,000 0,05616122 0,09654021 ! startle response GO:0001964 21 14 0,000 0,05616122 0,09646811 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,05616122 0,09639612 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05616122 0,09632423 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,05616122 0,09625246 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05616122 0,09618079 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05616122 0,09610922 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05616122 0,09603777 ! glycine metabolic process GO:0006544 22 14 0,000 0,05616122 0,09596642 ! pituitary gland development GO:0021983 23 14 0,000 0,05616122 0,09589517 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05616122 0,09582403 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,05616122 0,095753 ! regulation of heart rate GO:0002027 23 14 0,000 0,05616122 0,09568207 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05616122 0,09561125 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05616122 0,09554053 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05616122 0,09546992 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05616122 0,09539941 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05616122 0,095329 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,05616122 0,0952587 ! axon cargo transport GO:0008088 27 14 0,000 0,05616122 0,0951885 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05616122 0,09511841 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05616122 0,09504842 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05616122 0,09497853 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05616122 0,09490874 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05616122 0,09483906 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05616122 0,09476948 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05616122 0,0947 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05616122 0,09463062 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05616122 0,09456135 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05616122 0,09449217 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05616122 0,0944231 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05616122 0,09435413 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,05616122 0,09428525 ! muscle maintenance GO:0046716 19 14 0,000 0,05616122 0,09421648 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05616122 0,09414781 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05616122 0,09407924 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,05616122 0,09401077 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05616122 0,0939424 ! cell killing GO:0001906 20 14 0,000 0,05616122 0,09387413 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,05616122 0,09380595 ! cilium assembly GO:0042384 20 14 0,000 0,05616122 0,09373788 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05616122 0,0936699 ! response to oxidative stress GO:0006979 141 94 1,000 0,05736641 0,09561069 ! regulation of binding GO:0051098 151 95 1,000 0,05844801 0,09734281 ! angiogenesis GO:0001525 149 95 1,000 0,05844801 0,09727238 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,05953671 0,09901261 ! in utero embryonic development GO:0001701 147 96 1,000 0,05953671 0,09894107 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,06005155 0,0997246 ! positive regulation of cell size GO:0045793 20 15 0,000 0,06005155 0,09965265 ! metencephalon development GO:0022037 19 15 0,000 0,06005155 0,0995808 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,06005155 0,09950906 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,06005155 0,09943742 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,06005155 0,09936588 ! skin development GO:0043588 25 15 0,000 0,06005155 0,09929444 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,06005155 0,09922311 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,06005155 0,09915188 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,06005155 0,09908075 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,06005155 0,09900973 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,06005155 0,0989388 ! bile acid metabolic process GO:0008206 22 15 0,000 0,06005155 0,09886798 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,06005155 0,09879726 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,06005155 0,09872664 ! adult walking behavior GO:0007628 25 15 0,000 0,06005155 0,09865612 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,06005155 0,0985857 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,06005155 0,09851539 ! myoblast differentiation GO:0045445 27 15 0,000 0,06005155 0,09844517 ! centrosome cycle GO:0007098 16 15 0,000 0,06005155 0,09837505 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,06005155 0,09830503 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,06005155 0,09823511 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,06005155 0,0981653 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,06005155 0,09809558 ! cerebral cortex development GO:0021987 29 15 0,000 0,06005155 0,09802596 ! response to osmotic stress GO:0006970 22 15 0,000 0,06005155 0,09795643 ! vesicle coating GO:0006901 25 15 0,000 0,06005155 0,09788701 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,06005155 0,09781768 ! DNA integration GO:0015074 22 15 0,000 0,06005155 0,09774846 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,06005155 0,09767933 ! peptide secretion GO:0002790 27 15 0,000 0,06005155 0,0976103 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,06005155 0,09754136 ! regulation of vasodilation GO:0042312 24 15 0,000 0,06005155 0,09747253 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,06005155 0,09740379 ! neuron recognition GO:0008038 22 15 0,000 0,06005155 0,09733515 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,06005155 0,0972666 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,06005155 0,09719815 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,06005155 0,0971298 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,06005155 0,09706154 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,06005155 0,09699338 ! biomineral formation GO:0031214 18 15 0,000 0,06005155 0,09692531 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,06005155 0,09685734 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,06005155 0,09678947 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,06005155 0,09672169 ! dopamine metabolic process GO:0042417 30 15 0,000 0,06005155 0,096654 ! organic cation transport GO:0015695 19 15 0,000 0,06005155 0,09658641 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,06005155 0,09651892 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,06005155 0,09645152 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,06005155 0,09638421 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,06005155 0,09631699 ! peptide hormone processing GO:0016486 19 15 0,000 0,06005155 0,09624988 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,06005155 0,09618285 ! protein import GO:0017038 156 99 1,000 0,0628447 0,10058651 ! protein secretion GO:0009306 27 16 0,000 0,06392608 0,10224616 ! hormone secretion GO:0046879 25 16 0,000 0,06392608 0,1021751 ! bone remodeling GO:0046849 24 16 0,000 0,06392608 0,10210415 ! endothelial cell migration GO:0043542 22 16 0,000 0,06392608 0,10203329 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06392608 0,10196253 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06392608 0,10189187 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06392608 0,10182131 ! glial cell development GO:0021782 24 16 0,000 0,06392608 0,10175085 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06392608 0,10168048 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06392608 0,10161021 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06392608 0,10154004 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06392608 0,10146996 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,06392608 0,10139998 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,06392608 0,1013301 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,06392608 0,10126031 ! fructose metabolic process GO:0006000 20 16 0,000 0,06392608 0,10119062 ! regulation of protein binding GO:0043393 27 16 0,000 0,06392608 0,10112103 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,06392608 0,10105153 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06392608 0,10098212 ! protein export from nucleus GO:0006611 24 16 0,000 0,06392608 0,10091282 ! negative regulation of immune response GO:0050777 28 16 0,000 0,06392608 0,1008436 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06392608 0,10077448 ! DNA replication initiation GO:0006270 25 16 0,000 0,06392608 0,10070546 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,06392608 0,10063653 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06392608 0,1005677 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06392608 0,10049896 ! diencephalon development GO:0021536 25 16 0,000 0,06392608 0,10043031 ! oogenesis GO:0048477 23 16 0,000 0,06392608 0,10036176 ! neural crest cell migration GO:0001755 24 16 0,000 0,06392608 0,1002933 ! G1 phase GO:0051318 27 16 0,000 0,06392608 0,10022493 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,06392608 0,10015666 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06392608 0,10008848 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,06392608 0,10002039 ! steroid catabolic process GO:0006706 22 16 0,000 0,06392608 0,09995239 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,06392608 0,09988449 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,06392608 0,09981668 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06392608 0,09974896 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06392608 0,09968134 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06392608 0,0996138 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,06392608 0,09954636 ! nerve development GO:0021675 18 16 0,000 0,06392608 0,09947901 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06392608 0,09941175 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,06392608 0,09934458 ! negative regulation of translation GO:0017148 22 16 0,000 0,06392608 0,0992775 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,06396108 0,09926484 ! protein localization in organelle GO:0033365 161 100 1,000 0,06396108 0,0991979 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06778485 0,10505738 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06778485 0,10498663 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06778485 0,10491598 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,06778485 0,10484543 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06778485 0,10477497 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06778485 0,1047046 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06778485 0,10463433 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06778485 0,10456415 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06778485 0,10449407 ! signal complex assembly GO:0007172 29 17 0,000 0,06778485 0,10442408 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06778485 0,10435418 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06778485 0,10428438 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,06778485 0,10421467 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06778485 0,10414506 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06778485 0,10407553 ! memory GO:0007613 25 17 0,000 0,06778485 0,1040061 ! keratinization GO:0031424 17 17 0,000 0,06778485 0,10393677 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06778485 0,10386752 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06778485 0,10379837 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06778485 0,10372931 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06778485 0,10366034 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,06778485 0,10359146 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06778485 0,10352268 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06778485 0,10345398 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06778485 0,10338538 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,06778485 0,10331687 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06778485 0,10324844 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06778485 0,10318011 ! membrane budding GO:0006900 29 17 0,000 0,06778485 0,10311187 ! heme metabolic process GO:0042168 27 17 0,000 0,06778485 0,10304372 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06778485 0,10297566 ! neuromuscular junction development GO:0007528 23 17 0,000 0,06778485 0,10290769 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,06778485 0,10283981 ! body fluid secretion GO:0007589 27 17 0,000 0,06778485 0,10277202 ! stem cell differentiation GO:0048863 36 17 0,000 0,06778485 0,10270431 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06778485 0,1026367 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06778485 0,10256918 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06778485 0,10250174 ! sensory perception of pain GO:0019233 23 17 0,000 0,06778485 0,1024344 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06778485 0,10236714 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06778485 0,10229997 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,06778485 0,10223289 ! synaptogenesis GO:0007416 24 17 0,000 0,06778485 0,10216589 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06778485 0,10209898 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06778485 0,10203217 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06778485 0,10196543 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06778485 0,10189879 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06778485 0,10183223 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06778485 0,10176576 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,06778485 0,10169938 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06778485 0,10163308 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06778485 0,10156687 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,07162793 0,10725537 ! positive regulation of translation GO:0045727 28 18 0,000 0,07162793 0,10718559 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,07162793 0,1071159 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,07162793 0,10704629 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,07162793 0,10697678 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,07162793 0,10690736 ! cAMP metabolic process GO:0046058 33 18 0,000 0,07162793 0,10683803 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,07162793 0,10676879 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,07162793 0,10669964 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,07162793 0,10663058 ! axis specification GO:0009798 26 18 0,000 0,07162793 0,10656161 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,07162793 0,10649273 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,07162793 0,10642393 ! pancreas development GO:0031016 26 18 0,000 0,07162793 0,10635523 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,07162793 0,10628661 ! glutamine metabolic process GO:0006541 23 18 0,000 0,07162793 0,10621808 ! response to retinoic acid GO:0032526 25 18 0,000 0,07162793 0,10614964 ! central nervous system neuron development GO:0021954 30 18 0,000 0,07162793 0,10608129 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,07162793 0,10601303 ! fucose metabolic process GO:0006004 26 18 0,000 0,07162793 0,10594485 ! response to fungus GO:0009620 19 18 0,000 0,07162793 0,10587677 ! peptide cross-linking GO:0018149 31 18 0,000 0,07162793 0,10580876 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,07162793 0,10574085 ! heart process GO:0003015 27 18 0,000 0,07162793 0,10567303 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,07162793 0,10560529 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,07162793 0,10553763 ! visual learning GO:0008542 35 18 0,000 0,07162793 0,10547007 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,07162793 0,10540259 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,07162793 0,1053352 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,07162793 0,10526789 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,07162793 0,10520067 ! vitamin transport GO:0051180 24 18 0,000 0,07162793 0,10513353 ! hormone transport GO:0009914 27 18 0,000 0,07162793 0,10506648 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,07162793 0,10499952 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,07162793 0,10493264 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,07162793 0,10486585 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,07162793 0,10479914 ! cell-cell recognition GO:0009988 20 18 0,000 0,07162793 0,10473252 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,07162793 0,10466598 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,07162793 0,10459952 ! regulation of glucose import GO:0046324 21 18 0,000 0,07162793 0,10453315 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,07162793 0,10446687 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,07162793 0,10440066 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,07162793 0,10433455 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,0754554 0,10984013 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,0754554 0,10977066 ! positive regulation of ossification GO:0045778 30 19 0,000 0,0754554 0,10970127 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,0754554 0,10963197 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,0754554 0,10956276 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,0754554 0,10949363 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,0754554 0,1094246 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,0754554 0,10935565 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,0754554 0,10928678 ! regeneration GO:0031099 32 19 0,000 0,0754554 0,109218 ! response to alkaloid GO:0043279 32 19 0,000 0,0754554 0,10914931 ! sensory perception of taste GO:0050909 23 19 0,000 0,0754554 0,10908071 ! smooth muscle contraction GO:0006939 36 19 0,000 0,0754554 0,10901219 ! peroxisome organization GO:0007031 29 19 0,000 0,0754554 0,10894376 ! digestive system process GO:0022600 30 19 0,000 0,0754554 0,10887541 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,0754554 0,10880715 ! response to vitamin A GO:0033189 26 19 0,000 0,0754554 0,10873898 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,0754554 0,10867089 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,0754554 0,10860288 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,0754554 0,10853496 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,0754554 0,10846713 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,0754554 0,10839938 ! plasma membrane fusion GO:0045026 23 19 0,000 0,0754554 0,10833172 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,0754554 0,10826414 ! cytolysis GO:0019835 20 19 0,000 0,0754554 0,10819664 ! renal system process GO:0003014 35 19 0,000 0,0754554 0,10812923 ! vasodilation GO:0042311 33 19 0,000 0,0754554 0,1080619 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,0754554 0,10799465 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,0754554 0,10792749 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,0754554 0,10786042 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,0754554 0,10779342 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,0754554 0,10772651 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,0754554 0,10765968 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,0754554 0,10759294 ! sarcomere organization GO:0045214 23 19 0,000 0,0754554 0,10752628 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,0754554 0,1074597 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,0754554 0,1073932 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,0754554 0,10732678 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,0754554 0,10726045 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,0754554 0,1071942 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,0754554 0,10712803 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,0754554 0,10706194 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,0754554 0,10699594 ! protein stabilization GO:0050821 26 19 0,000 0,0754554 0,10693001 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,0792673 0,11226279 ! iron ion transport GO:0006826 37 20 0,000 0,0792673 0,11219371 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,0792673 0,11212471 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,0792673 0,1120558 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,0792673 0,11198696 ! response to vitamin GO:0033273 29 20 0,000 0,0792673 0,11191822 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,0792673 0,11184956 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,0792673 0,11178098 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,0792673 0,11171249 ! spinal cord development GO:0021510 31 20 0,000 0,0792673 0,11164408 ! response to ethanol GO:0045471 37 20 0,000 0,0792673 0,11157575 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,0792673 0,11150751 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,0792673 0,11143935 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,0792673 0,11137128 ! chromosome condensation GO:0030261 31 20 0,000 0,0792673 0,11130328 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,0792673 0,11123537 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,0792673 0,11116755 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,0792673 0,1110998 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,0792673 0,11103214 ! pallium development GO:0021543 38 20 0,000 0,0792673 0,11096456 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,0792673 0,11089707 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,0792673 0,11082965 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,0792673 0,11076232 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,0792673 0,11069507 ! collagen catabolic process GO:0030574 25 20 0,000 0,0792673 0,1106279 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,0792673 0,11056081 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,0792673 0,11049381 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,0792673 0,11042688 ! alditol metabolic process GO:0019400 24 20 0,000 0,0792673 0,11036004 ! actin filament-based movement GO:0030048 34 20 0,000 0,0792673 0,11029327 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,0830637 0,11550574 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,0830637 0,11543595 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,0830637 0,11536624 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,0830637 0,11529662 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,0830637 0,11522708 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,0830637 0,11515763 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,0830637 0,11508825 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,0830637 0,11501897 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,0830637 0,11494976 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,0830637 0,11488064 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,0830637 0,1148116 ! vesicle docking GO:0048278 27 21 0,000 0,0830637 0,11474264 ! phototransduction GO:0007602 25 21 0,000 0,0830637 0,11467377 ! dendrite development GO:0016358 35 21 0,000 0,0830637 0,11460498 ! visual behavior GO:0007632 39 21 0,000 0,0830637 0,11453627 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,0830637 0,11446765 ! ovarian follicle development GO:0001541 30 21 0,000 0,0830637 0,1143991 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,0830637 0,11433064 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,0830637 0,11426226 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,0830637 0,11419396 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,0830637 0,11412575 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,0830637 0,11405761 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,0830637 0,11398956 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,0830637 0,11392159 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,0830637 0,1138537 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,0830637 0,11378589 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,0830637 0,11371816 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,0830637 0,11365051 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,0830637 0,11358294 ! fatty acid transport GO:0015908 30 21 0,000 0,0830637 0,11351545 ! immunoglobulin production GO:0002377 33 21 0,000 0,0830637 0,11344804 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,0830637 0,11338071 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,0830637 0,11331346 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,0830637 0,1132463 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,0830637 0,11317921 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,0830637 0,1131122 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,0830637 0,11304527 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,0830637 0,11297842 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,0830637 0,11291164 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,0830637 0,11284495 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,0830637 0,11277834 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,0830637 0,1127118 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,0830637 0,11264534 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,0830637 0,11257896 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,08684466 0,11763411 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,08684466 0,11756487 ! viral genome replication GO:0019079 29 22 0,000 0,08684466 0,11749572 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,08684466 0,11742664 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,08684466 0,11735765 ! leukocyte adhesion GO:0007159 38 22 0,000 0,08684466 0,11728874 ! molting cycle process GO:0022404 40 22 0,000 0,08684466 0,11721991 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,08684466 0,11715115 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,08684466 0,11708248 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,08684466 0,11701389 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,08684466 0,11694539 ! vasculogenesis GO:0001570 33 22 0,000 0,08684466 0,11687696 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,08684466 0,11680861 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,08684466 0,11674034 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,08684466 0,11667215 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,08684466 0,11660404 ! lysosome organization GO:0007040 37 22 0,000 0,08684466 0,11653601 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,08684466 0,11646806 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,08684466 0,11640019 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,08684466 0,11633239 ! regulation of behavior GO:0050795 38 22 0,000 0,08684466 0,11626468 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,08684466 0,11619704 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,08684466 0,11612949 ! membrane depolarization GO:0051899 35 22 0,000 0,08684466 0,11606201 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,08684466 0,11599461 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,08684466 0,11592729 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,08684466 0,11586005 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,08684466 0,11579288 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,08684466 0,11572579 ! blastocyst development GO:0001824 37 22 0,000 0,08684466 0,11565878 ! neural tube closure GO:0001843 33 22 0,000 0,08684466 0,11559185 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,08684466 0,115525 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,09061025 0,12046449 ! neuron fate commitment GO:0048663 32 23 0,000 0,09061025 0,1203949 ! embryonic pattern specification GO:0009880 31 23 0,000 0,09061025 0,12032539 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,09061025 0,12025596 ! myelination GO:0042552 35 23 0,000 0,09061025 0,12018661 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,09061025 0,12011733 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,09061025 0,12004814 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,09061025 0,11997903 ! vesicle targeting GO:0006903 32 23 0,000 0,09061025 0,11991 ! osteoblast differentiation GO:0001649 40 23 0,000 0,09061025 0,11984104 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,09061025 0,11977217 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,09061025 0,11970337 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,09061025 0,11963466 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,09061025 0,11956602 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,09061025 0,11949746 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,09061025 0,11942898 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,09061025 0,11936058 ! cell fate determination GO:0001709 45 23 0,000 0,09061025 0,11929226 ! pentose metabolic process GO:0019321 31 23 0,000 0,09061025 0,11922401 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,09061025 0,11915585 ! spermatid development GO:0007286 33 23 0,000 0,09061025 0,11908776 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,09061025 0,11901974 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,09061025 0,11895181 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,09061025 0,11888396 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,09061025 0,11881618 ! telomere organization GO:0032200 32 23 0,000 0,09061025 0,11874847 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,09061025 0,11868085 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,09061025 0,1186133 ! regulation of amine transport GO:0051952 38 23 0,000 0,09061025 0,11854583 ! liver development GO:0001889 40 23 0,000 0,09061025 0,11847844 ! initiation of viral infection GO:0019059 42 24 0,000 0,09436052 0,12331205 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,09436052 0,12324203 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,09436052 0,12317208 ! superoxide metabolic process GO:0006801 32 24 0,000 0,09436052 0,12310222 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,09436052 0,12303243 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,09436052 0,12296272 ! fat cell differentiation GO:0045444 37 24 0,000 0,09436052 0,1228931 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,09436052 0,12282355 ! sperm motility GO:0030317 27 24 0,000 0,09436052 0,12275408 ! vacuole organization GO:0007033 39 24 0,000 0,09436052 0,12268468 ! receptor metabolic process GO:0043112 37 24 0,000 0,09436052 0,12261537 ! neural crest cell development GO:0014032 39 24 0,000 0,09436052 0,12254614 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,09436052 0,12247698 ! primary neural tube formation GO:0014020 35 24 0,000 0,09436052 0,1224079 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,09436052 0,1223389 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,09436052 0,12226998 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,09436052 0,12220113 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,09436052 0,12213236 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,09436052 0,12206367 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,09436052 0,12199506 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,09809555 0,12675268 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,09809555 0,12668151 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,09809555 0,12661042 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,09809555 0,12653941 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,09809555 0,12646848 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,09809555 0,12639763 ! peptide transport GO:0015833 43 25 0,000 0,09809555 0,12632685 ! male gonad development GO:0008584 33 25 0,000 0,09809555 0,12625616 ! iron ion homeostasis GO:0055072 39 25 0,000 0,09809555 0,12618555 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,09809555 0,12611501 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,09809555 0,12604456 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,09809555 0,12597418 ! phospholipid transport GO:0015914 35 25 0,000 0,09809555 0,12590388 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,09809555 0,12583367 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,09809555 0,12576352 ! detection of light stimulus GO:0009583 30 25 0,000 0,09809555 0,12569346 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,09809555 0,12562348 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,09809555 0,12555357 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,09809555 0,12548374 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,10181538 0,13016975 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,10181538 0,13009743 ! translational initiation GO:0006413 43 26 0,000 0,10181538 0,1300252 ! circadian rhythm GO:0007623 42 26 0,000 0,10181538 0,12995304 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,10181538 0,12988096 ! post-embryonic development GO:0009791 42 26 0,000 0,10181538 0,12980897 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,10181538 0,12973705 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,10181538 0,12966521 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,10181538 0,12959346 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,10181538 0,12952178 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,10181538 0,12945018 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,10181538 0,12937866 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,10181538 0,12930722 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,10181538 0,12923586 ! regulation of coagulation GO:0050818 39 26 0,000 0,10181538 0,12916458 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,10552008 0,13379062 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,10552008 0,13371691 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,10552008 0,13364328 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,10552008 0,13356973 ! membrane docking GO:0022406 39 27 0,000 0,10552008 0,13349626 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,10552008 0,13342287 ! catechol metabolic process GO:0009712 43 27 0,000 0,10552008 0,13334956 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,10552008 0,13327633 ! acute-phase response GO:0006953 42 27 0,000 0,10552008 0,13320318 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,10552008 0,13313011 ! myofibril assembly GO:0030239 36 27 0,000 0,10552008 0,13305712 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,10552008 0,13298422 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,10552008 0,13291139 ! natural killer cell activation GO:0030101 35 27 0,000 0,10552008 0,13283864 ! lipid oxidation GO:0034440 38 27 0,000 0,10552008 0,13276597 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,10552008 0,13269338 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,10552008 0,13262087 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,10552008 0,13254844 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,10552008 0,13247609 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,10552008 0,13240382 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,10552008 0,13233162 ! gene silencing GO:0016458 41 27 0,000 0,10552008 0,13225951 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,10920972 0,13680956 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,10920972 0,13673508 ! phenol metabolic process GO:0018958 44 28 0,000 0,10920972 0,13666069 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,10920972 0,13658638 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,10920972 0,13651215 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,10920972 0,136438 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,10920972 0,13636393 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,10920972 0,13628994 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,10920972 0,13621603 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,10920972 0,1361422 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,10920972 0,13606845 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,10920972 0,13599478 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,10920972 0,13592119 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,10920972 0,13584767 ! mesoderm formation GO:0001707 46 28 0,000 0,10920972 0,13577424 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,10920972 0,13570089 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,10920972 0,13562762 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,10920972 0,13555443 ! ensheathment of neurons GO:0007272 43 28 0,000 0,10920972 0,13548131 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,10920972 0,13540828 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,10920972 0,13533532 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,10920972 0,13526244 ! placenta development GO:0001890 37 28 0,000 0,10920972 0,13518964 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,11288434 0,13966325 ! regulation of innate immune response GO:0045088 38 29 0,000 0,11288434 0,13958817 ! ovulation cycle process GO:0022602 41 29 0,000 0,11288434 0,13951316 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,11288434 0,13943823 ! protein targeting to membrane GO:0006612 53 29 0,000 0,11288434 0,13936339 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,11288434 0,13928862 ! mismatch repair GO:0006298 34 29 0,000 0,11288434 0,13921393 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,11288434 0,13913933 ! muscle cell development GO:0055001 38 29 0,000 0,11288434 0,1390648 ! formation of primary germ layer GO:0001704 48 29 0,000 0,11288434 0,13899036 ! telencephalon development GO:0021537 52 29 0,000 0,11288434 0,13891599 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,11288434 0,1388417 ! eye morphogenesis GO:0048592 51 29 0,000 0,11288434 0,1387675 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,11288434 0,13869337 ! tissue homeostasis GO:0001894 42 29 0,000 0,11288434 0,13861932 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,11654402 0,14303695 ! collagen metabolic process GO:0032963 40 30 0,000 0,11654402 0,14296066 ! organic anion transport GO:0015711 51 30 0,000 0,11654402 0,14288446 ! cholesterol transport GO:0030301 46 30 0,000 0,11654402 0,14280833 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,11654402 0,14273229 ! spliceosome assembly GO:0000245 49 30 0,000 0,11654402 0,14265633 ! spindle organization GO:0007051 37 30 0,000 0,11654402 0,14258045 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,11654402 0,14250465 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,11654402 0,14242893 ! ceramide metabolic process GO:0006672 43 30 0,000 0,11654402 0,14235329 ! ovulation cycle GO:0042698 43 30 0,000 0,11654402 0,14227773 ! hindbrain development GO:0030902 45 30 0,000 0,11654402 0,14220225 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,11654402 0,14212685 ! adult locomotory behavior GO:0008344 47 30 0,000 0,11654402 0,14205153 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,11654402 0,14197629 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,11654402 0,14190113 ! response to heat GO:0009408 41 30 0,000 0,11654402 0,14182605 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,11654402 0,14175105 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,11654402 0,14167613 ! negative regulation of secretion GO:0051048 49 31 0,000 0,12018881 0,14602972 ! glial cell differentiation GO:0010001 55 31 0,000 0,12018881 0,14595262 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,12018881 0,1458756 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,12018881 0,14579866 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,12018881 0,1457218 ! odontogenesis GO:0042476 50 31 0,000 0,12018881 0,14564502 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,12018881 0,14556833 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,12018881 0,14549171 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,12018881 0,14541518 ! metanephros development GO:0001656 58 31 0,000 0,12018881 0,14533872 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,12018881 0,14526235 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,12018881 0,14518606 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,12018881 0,14510984 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,12018881 0,14503371 ! RNA modification GO:0009451 40 31 0,000 0,12018881 0,14495766 ! regulation of muscle development GO:0048634 48 32 0,000 0,12381876 0,14925742 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,12381876 0,14917923 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,12381876 0,14910113 ! meiosis I GO:0007127 52 32 0,000 0,12381876 0,14902311 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,12381876 0,14894517 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,12381876 0,14886731 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,12381876 0,14878953 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,12381876 0,14871183 ! regulation of protein stability GO:0031647 48 32 0,000 0,12381876 0,14863422 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,12381876 0,14855668 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,12381876 0,14847923 ! vesicle localization GO:0051648 47 32 0,000 0,12381876 0,14840185 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,12743395 0,15265526 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,12743395 0,15257579 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,12743395 0,15249641 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,12743395 0,15241711 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,12743395 0,15233789 ! sister chromatid segregation GO:0000819 46 33 0,000 0,12743395 0,15225875 ! ear morphogenesis GO:0042471 42 33 0,000 0,12743395 0,1521797 ! actomyosin structure organization GO:0031032 43 33 0,000 0,12743395 0,15210072 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,12743395 0,15202183 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,12743395 0,15194302 ! nucleus organization GO:0006997 49 33 0,000 0,12743395 0,1518643 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,12743395 0,15178565 ! female gonad development GO:0008585 49 33 0,000 0,12743395 0,15170709 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,12743395 0,1516286 ! positive regulation of cell development GO:0010720 54 33 0,000 0,12743395 0,1515502 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,12743395 0,15147188 ! regulation of proteolysis GO:0030162 50 33 0,000 0,12743395 0,15139364 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,12743395 0,15131548 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,12743395 0,15123741 ! cytokinesis GO:0000910 52 33 0,000 0,12743395 0,15115941 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,12743395 0,15108149 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,13103443 0,15527006 ! mRNA catabolic process GO:0006402 48 34 0,000 0,13103443 0,15519011 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,13103443 0,15511024 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,13103443 0,15503045 ! feeding behavior GO:0007631 45 34 0,000 0,13103443 0,15495074 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,13103443 0,15487112 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,13103443 0,15479157 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,13103443 0,15471211 ! neuron migration GO:0001764 46 34 0,000 0,13103443 0,15463273 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,13103443 0,15455343 ! female gamete generation GO:0007292 43 34 0,000 0,13103443 0,15447422 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,13103443 0,15439508 ! polyol metabolic process GO:0019751 44 34 0,000 0,13103443 0,15431602 ! aerobic respiration GO:0009060 47 34 0,000 0,13103443 0,15423705 ! embryonic organ development GO:0048568 45 34 0,000 0,13103443 0,15415816 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,13103443 0,15407934 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,13462026 0,15821492 ! Notch signaling pathway GO:0007219 56 35 0,000 0,13462026 0,15813412 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,13462026 0,15805339 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,13462026 0,15797275 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,13462026 0,1578922 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,13462026 0,15781172 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,13462026 0,15773133 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,13462026 0,15765102 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,13462026 0,15757079 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,13462026 0,15749064 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,13462026 0,15741057 ! glycogen metabolic process GO:0005977 48 35 0,000 0,13462026 0,15733059 ! pigment metabolic process GO:0042440 61 35 0,000 0,13462026 0,15725068 ! protein homooligomerization GO:0051260 52 35 0,000 0,13462026 0,15717086 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,1381915 0,16125847 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,1381915 0,16117669 ! negative regulation of binding GO:0051100 58 36 0,000 0,1381915 0,161095 ! organic ether metabolic process GO:0018904 46 36 0,000 0,1381915 0,16101339 ! tissue remodeling GO:0048771 62 36 0,000 0,1381915 0,16093187 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,1381915 0,16085042 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,1381915 0,16076906 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1381915 0,16068779 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,1381915 0,16060659 ! glucan metabolic process GO:0044042 49 36 0,000 0,1381915 0,16052547 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,1417482 0,16457388 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,1417482 0,16449084 ! learning GO:0007612 67 37 0,000 0,1417482 0,16440789 ! ion transmembrane transport GO:0034220 56 37 0,000 0,1417482 0,16432503 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,1417482 0,16424224 ! regulation of protein secretion GO:0050708 51 37 0,000 0,1417482 0,16415954 ! amino acid activation GO:0043038 52 37 0,000 0,1417482 0,16407693 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,1417482 0,16399439 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,14529042 0,16800803 ! gliogenesis GO:0042063 71 38 0,000 0,14529042 0,1679236 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,14529042 0,16783926 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,14529042 0,16775501 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,14529042 0,16767083 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,14529042 0,16758675 ! phagocytosis GO:0006909 60 38 0,000 0,14529042 0,16750274 ! mesenchymal cell development GO:0014031 64 38 0,000 0,14529042 0,16741882 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 0,000 0,14529042 0,16733499 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,14881823 0,17131228 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,14881823 0,17122658 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,14881823 0,17114097 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,14881823 0,17105544 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,14881823 0,17097 ! male sex differentiation GO:0046661 53 39 0,000 0,14881823 0,17088464 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,14881823 0,17079937 ! chromatin remodeling GO:0006338 68 39 0,000 0,14881823 0,17071418 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,14881823 0,17062908 ! JNK cascade GO:0007254 54 39 0,000 0,14881823 0,17054406 ! developmental growth GO:0048589 62 39 0,000 0,14881823 0,17045913 ! synapse organization GO:0050808 55 39 0,000 0,14881823 0,17037428 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,15233168 0,17430988 ! response to calcium ion GO:0051592 58 40 0,000 0,15233168 0,1742232 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,15233168 0,17413661 ! regulation of tube size GO:0035150 60 40 0,000 0,15233168 0,17405011 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,15233168 0,17396369 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,15233168 0,17387735 ! peptide metabolic process GO:0006518 56 40 0,000 0,15233168 0,1737911 ! inner ear development GO:0048839 57 40 0,000 0,15233168 0,17370494 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,15233168 0,17361886 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,15233168 0,17353287 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,15233168 0,17344696 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,15233168 0,17336114 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,15233168 0,1732754 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,15583083 0,17716802 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,15583083 0,17708048 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,15583083 0,17699304 ! glucose transport GO:0015758 52 41 0,000 0,15583083 0,17690568 ! endosome transport GO:0016197 71 41 0,000 0,15583083 0,1768184 ! striated muscle contraction GO:0006941 62 41 0,000 0,15583083 0,17673121 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,15583083 0,17664411 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,15583083 0,17655709 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,15583083 0,17647016 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,15931573 0,18032784 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,15931573 0,18023914 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,15931573 0,18015053 ! cellular component disassembly GO:0022411 64 42 0,000 0,15931573 0,180062 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,15931573 0,17997356 ! hexose transport GO:0008645 54 42 0,000 0,15931573 0,17988521 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,15931573 0,17979695 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,15931573 0,17970877 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,15931573 0,17962067 ! excretion GO:0007588 63 42 0,000 0,15931573 0,17953267 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,15931573 0,17944475 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,15931573 0,17935691 ! leukocyte migration GO:0050900 60 43 0,000 0,16278644 0,18317457 ! neuromuscular process GO:0050905 79 43 0,000 0,16278644 0,183085 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,16278644 0,18299551 ! tRNA processing GO:0008033 49 43 0,000 0,16278644 0,18290612 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,16278644 0,18281681 ! vesicle organization GO:0016050 79 43 0,000 0,16278644 0,18272758 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,16624303 0,18651657 ! glycolysis GO:0006096 53 44 0,000 0,16624303 0,18642563 ! regulation of action potential GO:0001508 71 44 0,000 0,16624303 0,18633478 ! regulation of ion transport GO:0043269 57 44 0,000 0,16624303 0,18624402 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,16624303 0,18615334 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,16624303 0,18606276 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,16624303 0,18597226 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,16624303 0,18588185 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,16624303 0,18579153 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,16624303 0,18570129 ! RNA catabolic process GO:0006401 64 45 0,000 0,16968554 0,18945473 ! regulation of translational initiation GO:0006446 64 45 0,000 0,16968554 0,1893628 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,16968554 0,18927097 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,16968554 0,18917922 ! cell recognition GO:0008037 58 45 0,000 0,16968554 0,18908757 ! cell maturation GO:0048469 60 45 0,000 0,16968554 0,188996 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,17311403 0,19272133 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,17311403 0,1926281 ! cell redox homeostasis GO:0045454 63 46 0,000 0,17311403 0,19253495 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,17311403 0,19244189 ! regulation of ossification GO:0030278 71 46 0,000 0,17311403 0,19234892 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,17311403 0,19225605 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,17652856 0,19595352 ! viral infectious cycle GO:0019058 71 47 0,000 0,17652856 0,195859 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,17652856 0,19576456 ! endocrine system development GO:0035270 83 47 0,000 0,17652856 0,19567022 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,17652856 0,19557596 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,17652856 0,1954818 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,17652856 0,19538773 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,17652856 0,19529375 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,17652856 0,19519986 ! chloride transport GO:0006821 67 48 0,000 0,17992919 0,19886456 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,17992919 0,19876904 ! response to temperature stimulus GO:0009266 62 48 0,000 0,17992919 0,19867362 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,17992919 0,19857828 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,17992919 0,19848304 ! gastrulation GO:0007369 73 48 0,000 0,17992919 0,19838789 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,17992919 0,19829283 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,17992919 0,19819787 ! regulation of endocytosis GO:0030100 63 48 0,000 0,17992919 0,19810299 ! nuclear export GO:0051168 69 48 0,000 0,17992919 0,1980082 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,17992919 0,19791351 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,17992919 0,1978189 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,18331597 0,20144612 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,18331597 0,20134992 ! sensory perception of smell GO:0007608 61 49 0,000 0,18331597 0,20125381 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,18331597 0,20115779 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,18331597 0,20106187 ! RNA elongation GO:0006354 62 49 0,000 0,18331597 0,20096603 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,18331597 0,20087029 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,18331597 0,20077464 ! germ cell development GO:0007281 68 49 0,000 0,18331597 0,20067907 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,18331597 0,2005836 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,18331597 0,20048822 ! cartilage development GO:0051216 70 49 0,000 0,18331597 0,20039293 ! maintenance of location GO:0051235 84 49 0,000 0,18331597 0,20029774 ! regulation of actin filament length GO:0030832 72 50 0,000 0,18668896 0,20388632 ! ear development GO:0043583 72 50 0,000 0,18668896 0,20378956 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,18668896 0,20369288 ! membrane fusion GO:0006944 80 50 0,000 0,18668896 0,2035963 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,18668896 0,20349981 ! proton transport GO:0015992 75 50 0,000 0,18668896 0,20340341 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,18668896 0,2033071 ! positive regulation of secretion GO:0051047 71 51 0,000 0,1900482 0,20686742 ! hydrogen transport GO:0006818 77 51 0,000 0,1900482 0,20676957 ! muscle fiber development GO:0048747 74 51 0,000 0,1900482 0,20667181 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,1900482 0,20657413 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,1900482 0,20647656 ! adult behavior GO:0030534 80 51 0,000 0,1900482 0,20637907 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,1900482 0,20628167 ! transition metal ion transport GO:0000041 74 52 0,000 0,19339377 0,20981399 ! regulation of cellular component size GO:0032535 74 52 0,000 0,19339377 0,20971507 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,19339377 0,20961624 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,1967257 0,21312723 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,1967257 0,21302689 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,1967257 0,21292664 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,1967257 0,21282649 ! kidney development GO:0001822 90 53 0,000 0,1967257 0,21272643 ! single fertilization GO:0007338 59 53 0,000 0,1967257 0,21262647 ! amino acid transport GO:0006865 84 54 0,000 0,20004407 0,21611149 ! regulation of mitosis GO:0007088 84 54 0,000 0,20004407 0,21601003 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,20004407 0,21590866 ! DNA catabolic process GO:0006308 67 54 0,000 0,20004407 0,21580739 ! detection of external stimulus GO:0009581 66 54 0,000 0,20004407 0,21570621 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,20004407 0,21560513 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,20004407 0,21550415 ! exocytosis GO:0006887 74 55 0,000 0,20334891 0,21896184 ! mesoderm development GO:0007498 76 55 0,000 0,20334891 0,21885938 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,20334891 0,21875701 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,20334891 0,21865474 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,20664029 0,22209003 ! carbohydrate transport GO:0008643 74 57 0,000 0,20991826 0,22550771 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,20991826 0,22540243 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,20991826 0,22529725 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,20991826 0,22519216 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,20991826 0,22508718 ! camera-type eye development GO:0043010 88 57 0,000 0,20991826 0,22498229 ! secondary metabolic process GO:0019748 84 57 0,000 0,20991826 0,2248775 ! developmental maturation GO:0021700 75 57 0,000 0,20991826 0,22477281 ! gonad development GO:0008406 79 57 0,000 0,20991826 0,22466822 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,21318287 0,2280561 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,21318287 0,22795007 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,21643418 0,23131906 ! actin filament organization GO:0007015 95 59 0,000 0,21643418 0,23121162 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,21643418 0,23110428 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,21967225 0,23445298 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,21967225 0,23434423 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,21967225 0,23423559 ! regulation of heart contraction GO:0008016 91 60 0,000 0,21967225 0,23412705 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,21967225 0,2340186 ! fertilization GO:0009566 68 60 0,000 0,21967225 0,23391026 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,21967225 0,23380202 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,22289711 0,23712459 ! meiosis GO:0007126 96 61 0,000 0,22289711 0,23701496 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,22289711 0,23690543 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,22289711 0,23679601 ! urogenital system development GO:0001655 101 61 0,000 0,22289711 0,23668668 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,22289711 0,23657746 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,22289711 0,23646834 ! extracellular matrix organization GO:0030198 103 61 0,000 0,22289711 0,23635932 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,22289711 0,23625039 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,22610883 0,23954413 ! neurotransmitter transport GO:0006836 81 62 0,000 0,22610883 0,23943385 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,22610883 0,23932366 ! meiotic cell cycle GO:0051321 97 62 0,000 0,22610883 0,23921358 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,22930746 0,24248605 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,22930746 0,24237462 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,23249306 0,24562886 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,23249306 0,24551609 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,23249306 0,24540341 ! hexose catabolic process GO:0019320 82 64 0,000 0,23249306 0,24529084 ! reproductive structure development GO:0048608 90 65 0,000 0,23566567 0,24852409 ! defense response to bacterium GO:0042742 73 65 0,000 0,23566567 0,24841019 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,23566567 0,2482964 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,23566567 0,24818271 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,23882534 0,2513951 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,23882534 0,2512801 ! antigen processing and presentation GO:0019882 96 66 0,000 0,23882534 0,2511652 ! axon guidance GO:0007411 99 66 0,000 0,23882534 0,25105041 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,23882534 0,25093572 ! regulation of immune effector process GO:0002697 101 66 0,000 0,23882534 0,25082114 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,24197214 0,25401 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,24197214 0,25389412 ! learning or memory GO:0007611 123 68 0,000 0,2451061 0,25706522 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,2451061 0,25694806 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,2451061 0,256831 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,2451061 0,25671404 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,2451061 0,25659719 ! rhythmic process GO:0048511 105 68 0,000 0,2451061 0,25648045 ! inorganic anion transport GO:0015698 93 68 0,000 0,2451061 0,25636382 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,24822729 0,25951035 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,24822729 0,25939244 ! response to metal ion GO:0010038 103 70 0,000 0,25133575 0,26252145 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,25133575 0,26240228 ! amine transport GO:0015837 101 70 0,000 0,25133575 0,26228323 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,25133575 0,26216428 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,25443154 0,26527314 ! muscle cell differentiation GO:0042692 104 71 0,000 0,25443154 0,26515294 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,25443154 0,26503285 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,25443154 0,26491287 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,2575147 0,26800172 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,2575147 0,26788051 ! negative regulation of transport GO:0051051 116 73 0,000 0,26058529 0,27095215 ! regulation of blood pressure GO:0008217 107 73 0,000 0,26058529 0,27082972 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,26058529 0,27070739 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,26364335 0,27376059 ! digestion GO:0007586 97 74 0,000 0,26364335 0,27363705 ! blood coagulation GO:0007596 116 75 0,000 0,26668895 0,27667324 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,26668895 0,2765485 ! response to nutrient GO:0007584 104 75 0,000 0,26668895 0,27642387 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,26668895 0,27629936 ! amine biosynthetic process GO:0009309 97 76 0,000 0,26972212 0,27931601 ! tRNA metabolic process GO:0006399 95 76 0,000 0,26972212 0,27919031 ! response to unfolded protein GO:0006986 99 76 0,000 0,26972212 0,27906472 ! regulation of protein transport GO:0051223 114 76 0,000 0,26972212 0,27893924 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,27274291 0,2819365 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,27274291 0,28180984 ! sex differentiation GO:0007548 105 77 0,000 0,27274291 0,2816833 ! protein ubiquitination GO:0016567 125 77 0,000 0,27274291 0,28155687 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,27274291 0,28143055 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,27274291 0,28130435 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,27575139 0,28427978 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,27575139 0,28415242 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,27575139 0,28402517 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,27874759 0,28698275 ! cellular respiration GO:0045333 107 79 0,000 0,27874759 0,28685434 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,27874759 0,28672606 ! regulation of lyase activity GO:0051339 133 79 0,000 0,27874759 0,28659788 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,27874759 0,28646982 ! chromatin assembly GO:0031497 102 80 0,000 0,28173157 0,28940715 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,28173157 0,28927795 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,28173157 0,28914887 ! forebrain development GO:0030900 131 80 0,000 0,28173157 0,2890199 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,28470337 0,29193837 ! hemostasis GO:0007599 125 81 0,000 0,28470337 0,29180827 ! mRNA transport GO:0051028 121 81 0,000 0,28470337 0,29167829 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,28470337 0,29154842 ! response to protein stimulus GO:0051789 111 81 0,000 0,28470337 0,29141867 ! regulation of neurological system process GO:0031644 122 81 0,000 0,28470337 0,29128904 ! vitamin metabolic process GO:0006766 103 81 0,000 0,28470337 0,29115952 ! detection of stimulus GO:0051606 108 82 0,000 0,28766305 0,29405556 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,29061065 0,29693669 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,29061065 0,29680484 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,29061065 0,2966731 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,29354623 0,29953696 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,29354623 0,29940413 ! sterol metabolic process GO:0016125 120 84 0,000 0,29354623 0,29927142 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,29646982 0,30211811 ! rRNA metabolic process GO:0016072 107 85 0,000 0,29646982 0,30198431 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,29646982 0,30185063 ! regulation of protein localization GO:0032880 132 85 0,000 0,29646982 0,30171707 ! regulation of membrane potential GO:0042391 128 85 0,000 0,29646982 0,30158363 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,29938148 0,30441088 ! nucleosome organization GO:0034728 114 87 0,000 0,30228126 0,30722355 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,30228126 0,30708785 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,30228126 0,30695227 ! female pregnancy GO:0007565 130 87 0,000 0,30228126 0,30681681 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,30228126 0,30668147 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,3051692 0,30947494 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,3051692 0,30933854 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,3051692 0,30920227 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,3051692 0,30906612 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,30804535 0,31184169 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,30804535 0,31170449 ! regulation of T cell activation GO:0050863 128 89 0,000 0,30804535 0,31156742 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,31090977 0,31432636 ! hormone metabolic process GO:0042445 121 90 0,000 0,31090977 0,31418825 ! RNA localization GO:0006403 135 91 0,000 0,31376249 0,3169318 ! ATP metabolic process GO:0046034 137 91 0,000 0,31376249 0,31679268 ! response to virus GO:0009615 122 91 0,000 0,31376249 0,31665367 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,31660356 0,31938078 ! DNA recombination GO:0006310 146 92 0,000 0,31660356 0,31924076 ! sulfur metabolic process GO:0006790 118 92 0,000 0,31660356 0,31910087 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,31943303 0,32181164 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,31943303 0,32167074 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,31943303 0,32152997 ! electron transport chain GO:0022900 123 94 0,000 0,32225095 0,32422449 ! carboxylic acid transport GO:0046942 147 95 0,000 0,32505737 0,32690509 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,32785232 0,32957183 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,32785232 0,32942785 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,33063586 0,33207969 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,33063586 0,33193474 ! calcium ion transport GO:0006816 167 99 0,000 0,33616888 0,33734225 ! extracellular structure organization GO:0043062 156 99 0,000 0,33616888 0,33719513 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,33616888 0,33704814 ! regulation of translation GO:0006417 151 100 0,000 0,33891846 0,33965684 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,33891846 0,33950891 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,33891846 0,3393611 ! divalent metal ion transport GO:0070838 171 100 0,000 0,33891846 0,33921343 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,33891846 0,33906588 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,33891846 0,33891846