pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1096-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 5,000 5,012E-10 1,153E-06 ! protein amino acid autophosphorylation GO:0046777 80 45 5,000 9,523E-08 1,095E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 1,136E-07 8,706E-05 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 4,000 1,136E-07 6,53E-05 ! positive regulation of cellular catabolic process GO:0031331 22 12 3,000 2,877E-07 1,323E-04 ! regulation of protein complex assembly GO:0043254 81 54 5,000 2,912E-07 1,116E-04 ! Ras protein signal transduction GO:0007265 162 100 6,000 7,043E-07 2,314E-04 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 7,146E-07 2,054E-04 ! regulation of vasodilation GO:0042312 24 15 3,000 7,842E-07 2,004E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 1,224E-06 2,814E-04 ! nuclear migration GO:0007097 10 5 2,000 1,224E-06 2,558E-04 ! positive regulation of vasoconstriction GO:0045907 9 5 2,000 1,224E-06 2,345E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 1,224E-06 2,165E-04 GO:0031272|regulation of pseudopodium assembly, ! positive regulation of microtubule polymerization GO:0031116 9 5 2,000 1,224E-06 2,01E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 1,357E-06 2,081E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 4,000 1,45E-06 2,084E-04 ! positive regulation of DNA replication GO:0045740 29 18 3,000 1,738E-06 2,351E-04 ! response to insulin stimulus GO:0032868 63 43 4,000 2,385E-06 3,048E-04 ! positive regulation of protein ubiquitination GO:0031398 8 6 2,000 2,438E-06 2,952E-04 ! macrophage differentiation GO:0030225 10 6 2,000 2,438E-06 2,804E-04 ! gas homeostasis GO:0033483 11 6 2,000 2,438E-06 2,67E-04 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 2,000 2,438E-06 2,549E-04 ! regulation of microtubule polymerization GO:0031113 11 6 2,000 2,438E-06 2,438E-04 ! positive regulation of cell cycle GO:0045787 77 45 4,000 3,004E-06 2,879E-04 ! myeloid leukocyte differentiation GO:0002573 33 21 3,000 3,36E-06 3,091E-04 ! vasculogenesis GO:0001570 33 22 3,000 4,091E-06 3,619E-04 ! regulation of DNA replication GO:0006275 75 48 4,000 4,16E-06 3,544E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 4,251E-06 3,492E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 4,251E-06 3,372E-04 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 4,251E-06 3,259E-04 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 2,000 4,251E-06 3,154E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 4,251E-06 3,056E-04 ! muscle adaptation GO:0043500 12 7 2,000 4,251E-06 2,963E-04 ! regulation of cellular catabolic process GO:0031329 36 24 3,000 5,897E-06 3,989E-04 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 2,000 6,777E-06 4,454E-04 GO:0046579|positive regulation of Ras protein signal transduction, ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 6,777E-06 4,33E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 6,777E-06 4,213E-04 ! regulation of cellular component biogenesis GO:0044087 158 96 5,000 8,83E-06 5,344E-04 ! regulation of lipid metabolic process GO:0019216 84 56 4,000 8,992E-06 5,303E-04 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 9,818E-06 5,645E-04 ! positive regulation of glucose metabolic process GO:0010907 15 9 2,000 1,013E-05 5,682E-04 ! regulation of epithelial cell differentiation GO:0030856 13 9 2,000 1,013E-05 5,547E-04 ! regulation of glycolysis GO:0006110 15 9 2,000 1,013E-05 5,418E-04 ! positive regulation of protein polymerization GO:0032273 15 9 2,000 1,013E-05 5,295E-04 ! nucleus localization GO:0051647 15 9 2,000 1,013E-05 5,177E-04 ! positive regulation of catabolic process GO:0009896 40 28 3,000 1,119E-05 5,595E-04 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,442E-05 7,055E-04 ! negative regulation of MAPKKK cascade GO:0043409 20 10 2,000 1,442E-05 6,908E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 1,442E-05 6,767E-04 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 1,609E-05 7,404E-04 ! mammary gland development GO:0030879 57 31 3,000 1,7E-05 7,666E-04 ! protein oligomerization GO:0051259 100 65 4,000 1,876E-05 8,3E-04 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 1,975E-05 8,571E-04 ! filopodium assembly GO:0046847 19 11 2,000 1,975E-05 8,413E-04 ! positive regulation of DNA metabolic process GO:0051054 54 33 3,000 2,194E-05 9,174E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 2,000 2,624E-05 1,078E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! gland morphogenesis GO:0022612 23 12 2,000 2,624E-05 1,059E-03 ! microspike assembly GO:0030035 23 12 2,000 2,624E-05 1,041E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 2,696E-05 1,051E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 3,092E-05 1,185E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 4,000 3,092E-05 1,166E-03 ! positive regulation of protein complex assembly GO:0031334 19 13 2,000 3,399E-05 1,261E-03 ! lipid localization GO:0010876 24 13 2,000 3,399E-05 1,241E-03 GO:0019915|lipid storage, ! regulation of cytokine production during immune response GO:0002718 18 13 2,000 3,399E-05 1,221E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 3,399E-05 1,203E-03 ! response to oxygen levels GO:0070482 137 74 4,000 3,532E-05 1,231E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 3,532E-05 1,212E-03 ! cell growth GO:0016049 61 39 3,000 4,309E-05 1,458E-03 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 2,000 4,31E-05 1,437E-03 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 2,000 4,31E-05 1,416E-03 ! regulation of protein ubiquitination GO:0031396 19 15 2,000 5,368E-05 1,739E-03 ! regulation of JAK-STAT cascade GO:0046425 61 42 3,000 5,797E-05 1,852E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 6,582E-05 2,074E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 6,582E-05 2,046E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 6,582E-05 2,019E-03 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 6,886E-05 2,084E-03 ! skeletal muscle tissue development GO:0007519 123 87 4,000 7,696E-05 2,299E-03 GO:0060538|skeletal muscle organ development, ! inactivation of MAPK activity GO:0000188 27 17 2,000 7,964E-05 2,348E-03 ! regulation of protein polymerization GO:0032271 71 47 3,000 9,063E-05 2,638E-03 ! positive regulation of anti-apoptosis GO:0045768 29 18 2,000 9,522E-05 2,738E-03 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 9,522E-05 2,704E-03 ! positive regulation of cytoskeleton organization GO:0051495 33 18 2,000 9,522E-05 2,671E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 3,000 9,849E-05 2,729E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 1,127E-04 3,085E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 1,127E-04 3,048E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,127E-04 3,013E-03 ! sex determination GO:0007530 29 19 2,000 1,127E-04 2,978E-03 ! regulation of fatty acid metabolic process GO:0019217 28 19 2,000 1,127E-04 2,945E-03 ! regulation of interleukin-2 production GO:0032663 31 19 2,000 1,127E-04 2,911E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 1,127E-04 2,879E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 1,25E-04 3,16E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,25E-04 3,126E-03 ! positive regulation of organelle organization GO:0010638 82 51 3,000 1,25E-04 3,092E-03 ! aging GO:0007568 79 52 3,000 1,349E-04 3,302E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,535E-04 3,717E-03 ! cell aging GO:0007569 32 21 2,000 1,535E-04 3,678E-03 ! regulation of vasoconstriction GO:0019229 31 21 2,000 1,535E-04 3,64E-03 ! regulation of anti-apoptosis GO:0045767 36 22 2,000 1,771E-04 4,157E-03 ! regulation of smooth muscle contraction GO:0006940 36 22 2,000 1,771E-04 4,115E-03 ! membrane depolarization GO:0051899 35 22 2,000 1,771E-04 4,073E-03 ! regulation of blood coagulation GO:0030193 34 22 2,000 1,771E-04 4,033E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 1,803E-04 4,065E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 1,932E-04 4,313E-03 ! cellular response to oxidative stress GO:0034599 33 23 2,000 2,029E-04 4,488E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 2,067E-04 4,527E-03 ! myeloid cell differentiation GO:0030099 85 59 3,000 2,209E-04 4,792E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 2,311E-04 4,967E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 2,311E-04 4,921E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 2,311E-04 4,876E-03 ! protein maturation by protein folding GO:0022417 12 5 1,000 2,481E-04 5,187E-03 ! lipoprotein particle clearance GO:0034381 9 5 1,000 2,481E-04 5,14E-03 ! anagen GO:0042640 6 5 1,000 2,481E-04 5,094E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 1,000 2,481E-04 5,049E-03 ! response to food GO:0032094 5 5 1,000 2,481E-04 5,005E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 2,481E-04 4,961E-03 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 1,000 2,481E-04 4,919E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,481E-04 4,876E-03 ! regulation of muscle cell apoptosis GO:0010660 8 5 1,000 2,481E-04 4,835E-03 ! porphyrin catabolic process GO:0006787 12 5 1,000 2,481E-04 4,795E-03 GO:0033015|tetrapyrrole catabolic process, ! somatic stem cell maintenance GO:0035019 13 5 1,000 2,481E-04 4,755E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 2,513E-04 4,777E-03 ! regulation of cellular ketone metabolic process GO:0010565 34 25 2,000 2,616E-04 4,932E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 2,947E-04 5,51E-03 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 2,947E-04 5,466E-03 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 2,947E-04 5,422E-03 ! regulation of coagulation GO:0050818 39 26 2,000 2,947E-04 5,379E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 3,025E-04 5,478E-03 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 2,000 3,303E-04 5,935E-03 ! negative regulation of neuron apoptosis GO:0043524 42 27 2,000 3,303E-04 5,889E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 3,686E-04 6,522E-03 ! cholesterol homeostasis GO:0042632 46 28 2,000 3,686E-04 6,472E-03 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 2,000 3,686E-04 6,423E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 3,686E-04 6,374E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 3,709E-04 6,366E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,709E-04 6,319E-03 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 3,709E-04 6,272E-03 GO:0031958|corticosteroid receptor signaling pathway, ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 3,709E-04 6,226E-03 ! male sex determination GO:0030238 9 6 1,000 3,709E-04 6,181E-03 ! positive regulation of cytokine production during immune response GO:0002720 8 6 1,000 3,709E-04 6,137E-03 ! hair follicle maturation GO:0048820 7 6 1,000 3,709E-04 6,093E-03 ! regulation of interleukin-13 production GO:0032656 11 6 1,000 3,709E-04 6,05E-03 ! regulation of meiosis GO:0040020 10 6 1,000 3,709E-04 6,007E-03 GO:0051445|regulation of meiotic cell cycle, ! regulation of mast cell activation GO:0033003 6 6 1,000 3,709E-04 5,965E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 3,709E-04 5,924E-03 GO:0043011|myeloid dendritic cell differentiation, ! regulation of myoblast differentiation GO:0045661 8 6 1,000 3,709E-04 5,883E-03 ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 3,709E-04 5,843E-03 ! regulation of catabolic process GO:0009894 106 70 3,000 4,266E-04 6,675E-03 ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 4,503E-04 6,999E-03 ! cholesterol transport GO:0030301 46 30 2,000 4,535E-04 7,001E-03 GO:0015918|sterol transport, ! regulation of microtubule-based process GO:0032886 58 30 2,000 4,535E-04 6,954E-03 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 1,000 5,175E-04 7,883E-03 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 5,175E-04 7,831E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! vesicle fusion GO:0006906 15 7 1,000 5,175E-04 7,78E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 5,175E-04 7,729E-03 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 1,000 5,175E-04 7,679E-03 ! regulation of interleukin-10 production GO:0032653 11 7 1,000 5,175E-04 7,63E-03 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 5,175E-04 7,582E-03 ! neuroblast proliferation GO:0007405 13 7 1,000 5,175E-04 7,534E-03 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 5,175E-04 7,486E-03 ! neutral lipid metabolic process GO:0006638 41 32 2,000 5,5E-04 7,907E-03 GO:0006639|acylglycerol metabolic process, ! lipid homeostasis GO:0055088 55 33 2,000 6,028E-04 8,612E-03 ! cytokinesis GO:0000910 52 33 2,000 6,028E-04 8,559E-03 ! gland development GO:0048732 148 77 3,000 6,13E-04 8,65E-03 ! regulation of DNA binding GO:0051101 119 77 3,000 6,13E-04 8,597E-03 ! positive regulation of protein modification process GO:0031401 107 78 3,000 6,437E-04 8,973E-03 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 6,588E-04 9,128E-03 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 6,588E-04 9,073E-03 ! glycerol ether metabolic process GO:0006662 44 34 2,000 6,588E-04 9,019E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 6,878E-04 9,36E-03 ! multicellular organism growth GO:0035264 14 8 1,000 6,878E-04 9,305E-03 ! positive regulation of vasodilation GO:0045909 12 8 1,000 6,878E-04 9,251E-03 ! regulation of interleukin-4 production GO:0032673 16 8 1,000 6,878E-04 9,197E-03 ! induction of an organ GO:0001759 11 8 1,000 6,878E-04 9,144E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 6,878E-04 9,091E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 6,878E-04 9,039E-03 ! protein homooligomerization GO:0051260 52 35 2,000 7,179E-04 9,382E-03 ! response to reactive oxygen species GO:0000302 55 36 2,000 7,804E-04 0,01014043 ! organic ether metabolic process GO:0018904 46 36 2,000 7,804E-04 0,01008346 ! tissue remodeling GO:0048771 62 36 2,000 7,804E-04 0,01002713 ! regulation of developmental growth GO:0048638 13 9 1,000 8,814E-04 0,01126227 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 8,814E-04 0,01120005 ! sequestering of metal ion GO:0051238 11 9 1,000 8,814E-04 0,01113851 ! response to nicotine GO:0035094 16 9 1,000 8,814E-04 0,01107764 ! localization within membrane GO:0051668 15 9 1,000 8,814E-04 0,01101744 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 8,896E-04 0,01106023 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 2,000 9,88E-04 0,0122177 ! developmental growth GO:0048589 62 39 2,000 9,88E-04 0,01215236 ! inner ear development GO:0048839 57 40 2,000 1,064E-03 0,01302049 ! JAK-STAT cascade GO:0007259 53 40 2,000 1,064E-03 0,0129516 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 1,098E-03 0,01329326 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 1,098E-03 0,01322367 ! sulfate transport GO:0008272 12 10 1,000 1,098E-03 0,01315479 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 1,098E-03 0,01308663 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 1,098E-03 0,01301918 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,098E-03 0,01295241 ! glucan biosynthetic process GO:0009250 13 10 1,000 1,098E-03 0,01288633 GO:0005978|glycogen biosynthetic process, ! developmental induction GO:0031128 13 10 1,000 1,098E-03 0,01282092 GO:0045168|cell-cell signaling involved in cell fate specification, ! negative regulation of immune effector process GO:0002698 16 10 1,000 1,098E-03 0,01275616 ! leukocyte differentiation GO:0002521 143 90 3,000 1,101E-03 0,01273051 ! positive regulation of DNA binding GO:0043388 57 41 2,000 1,144E-03 0,01315772 ! regulation of leukocyte mediated immunity GO:0002703 62 41 2,000 1,144E-03 0,01309226 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 2,000 1,228E-03 0,01397878 ! regulation of cytoskeleton organization GO:0051493 154 93 3,000 1,244E-03 0,01409798 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 1,244E-03 0,01402887 ! positive regulation of binding GO:0051099 59 43 2,000 1,315E-03 0,0147537 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 1,315E-03 0,01468208 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 1,315E-03 0,01461115 ! vesicle organization GO:0016050 79 43 2,000 1,315E-03 0,01454091 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 1,338E-03 0,01472199 ! virus-host interaction GO:0019048 17 11 1,000 1,338E-03 0,01465189 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 1,000 1,338E-03 0,01458245 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! stem cell development GO:0048864 29 11 1,000 1,338E-03 0,01451366 GO:0019827|stem cell maintenance, ! regulation of phagocytosis GO:0050764 14 11 1,000 1,338E-03 0,01444552 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 1,338E-03 0,01437802 ! T cell homeostasis GO:0043029 20 11 1,000 1,338E-03 0,01431115 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,338E-03 0,01424489 ! regulation of binding GO:0051098 151 95 3,000 1,346E-03 0,01427088 ! response to light stimulus GO:0009416 153 96 3,000 1,4E-03 0,01476668 ! regulation of cell projection organization GO:0031344 83 44 2,000 1,406E-03 0,01476745 ! negative regulation of cell migration GO:0030336 92 44 2,000 1,406E-03 0,01470033 ! response to UV GO:0009411 75 46 2,000 1,6E-03 0,01665187 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 1,000 1,6E-03 0,0165775 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 1,6E-03 0,01650316 ! histone acetylation GO:0016573 23 12 1,000 1,6E-03 0,01642949 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,6E-03 0,01635647 ! regulation of translation GO:0006417 151 100 3,000 1,627E-03 0,01655931 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 1,703E-03 0,01725448 ! regulation of muscle contraction GO:0006937 69 48 2,000 1,81E-03 0,01825782 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,885E-03 0,01893066 ! regulation of chemokine production GO:0032642 17 13 1,000 1,885E-03 0,01884835 ! organelle fusion GO:0048284 28 13 1,000 1,885E-03 0,01876676 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 1,885E-03 0,01868587 ! regulation of exocytosis GO:0017157 17 13 1,000 1,885E-03 0,01860567 ! tissue regeneration GO:0042246 21 13 1,000 1,885E-03 0,01852616 ! lymphocyte homeostasis GO:0002260 24 13 1,000 1,885E-03 0,01844732 ! ear development GO:0043583 72 50 2,000 2,036E-03 0,0198444 ! positive regulation of growth GO:0045927 67 50 2,000 2,036E-03 0,01976067 ! negative regulation of cell motion GO:0051271 104 51 2,000 2,156E-03 0,02083197 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 2,192E-03 0,02109255 ! myotube differentiation GO:0014902 21 14 1,000 2,192E-03 0,02100467 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,192E-03 0,02091751 ! water homeostasis GO:0030104 24 14 1,000 2,192E-03 0,02083107 ! establishment of organelle localization GO:0051656 85 52 2,000 2,279E-03 0,02157431 ! cell projection assembly GO:0030031 76 53 2,000 2,407E-03 0,02269281 ! lipid phosphorylation GO:0046834 23 15 1,000 2,521E-03 0,02366401 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 2,521E-03 0,02356782 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 1,000 2,521E-03 0,0234724 ! myoblast differentiation GO:0045445 27 15 1,000 2,521E-03 0,02337776 ! positive regulation of proteolysis GO:0045862 19 15 1,000 2,521E-03 0,02328387 ! regulation of survival gene product expression GO:0045884 20 15 1,000 2,521E-03 0,02319073 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 2,521E-03 0,02309834 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 2,521E-03 0,02300668 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 2,521E-03 0,02291574 ! regulation of T-helper cell differentiation GO:0045622 23 15 1,000 2,521E-03 0,02282552 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,871E-03 0,0258992 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 1,000 2,871E-03 0,02579803 ! protein export from nucleus GO:0006611 24 16 1,000 2,871E-03 0,02569765 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 2,871E-03 0,02559805 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 1,000 2,871E-03 0,02549921 ! negative regulation of translation GO:0017148 22 16 1,000 2,871E-03 0,02540114 ! regulation of cytokine biosynthetic process GO:0042035 76 58 2,000 3,114E-03 0,02744286 ! signal complex assembly GO:0007172 29 17 1,000 3,244E-03 0,02847499 ! heme metabolic process GO:0042168 27 17 1,000 3,244E-03 0,02836672 ! stem cell differentiation GO:0048863 36 17 1,000 3,244E-03 0,02825927 ! peptidyl-serine modification GO:0018209 27 17 1,000 3,244E-03 0,02815263 ! lung development GO:0030324 94 59 2,000 3,269E-03 0,02826723 ! regulation of vesicle-mediated transport GO:0060627 79 60 2,000 3,429E-03 0,02953667 ! cell-matrix adhesion GO:0007160 114 61 2,000 3,593E-03 0,03083696 ! homeostasis of number of cells GO:0048872 84 61 2,000 3,593E-03 0,03072232 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 3,637E-03 0,0309838 ! visual learning GO:0008542 35 18 1,000 3,637E-03 0,03086947 ! somitogenesis GO:0001756 24 18 1,000 3,637E-03 0,03075598 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 3,637E-03 0,03064332 ! cellular response to nutrient levels GO:0031669 27 18 1,000 3,637E-03 0,03053148 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 3,637E-03 0,03042046 ! respiratory tube development GO:0030323 99 62 2,000 3,762E-03 0,03135227 ! organelle localization GO:0051640 96 62 2,000 3,762E-03 0,03123908 ! regulation of transcription factor activity GO:0051090 97 63 2,000 3,936E-03 0,03256529 GO:0090046|regulation of transcription regulator activity, ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 4,052E-03 0,03340263 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 4,052E-03 0,03328333 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 4,052E-03 0,03316489 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 4,052E-03 0,03304728 ! regeneration GO:0031099 32 19 1,000 4,052E-03 0,03293051 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 4,052E-03 0,03281455 ! response to alkaloid GO:0043279 32 19 1,000 4,052E-03 0,03269941 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 4,052E-03 0,03258508 ! response to lipopolysaccharide GO:0032496 26 19 1,000 4,052E-03 0,03247154 ! protein stabilization GO:0050821 26 19 1,000 4,052E-03 0,0323588 ! respiratory system development GO:0060541 100 64 2,000 4,115E-03 0,032748 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 4,298E-03 0,03409098 ! cell-substrate adhesion GO:0031589 121 66 2,000 4,487E-03 0,03546347 ! regulation of Rho protein signal transduction GO:0035023 111 66 2,000 4,487E-03 0,03534202 ! regulation of immune effector process GO:0002697 101 66 2,000 4,487E-03 0,0352214 ! collagen catabolic process GO:0030574 25 20 1,000 4,487E-03 0,03510567 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 4,944E-03 0,03854348 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 4,944E-03 0,03841327 ! protein amino acid acylation GO:0043543 37 21 1,000 4,944E-03 0,03828393 ! vesicle docking GO:0048278 27 21 1,000 4,944E-03 0,03815546 ! visual behavior GO:0007632 39 21 1,000 4,944E-03 0,03802785 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 4,944E-03 0,03790109 ! platelet activation GO:0030168 28 21 1,000 4,944E-03 0,03777518 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 4,944E-03 0,03765009 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 4,944E-03 0,03752584 ! porphyrin metabolic process GO:0006778 35 21 1,000 4,944E-03 0,03740239 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 1,000 4,944E-03 0,03727976 ! activation of protein kinase activity GO:0032147 102 69 2,000 5,082E-03 0,03819889 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 5,42E-03 0,04060791 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 5,42E-03 0,04047606 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 5,42E-03 0,04034507 ! molting cycle process GO:0022404 40 22 1,000 5,42E-03 0,04021493 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 38 22 1,000 5,42E-03 0,04008562 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 5,42E-03 0,03995714 GO:0010810|regulation of cell-substrate adhesion, ! proteoglycan biosynthetic process GO:0030166 32 22 1,000 5,42E-03 0,03982948 ! leukocyte homeostasis GO:0001776 33 22 1,000 5,42E-03 0,03970263 ! protein tetramerization GO:0051262 39 22 1,000 5,42E-03 0,03957659 ! muscle cell differentiation GO:0042692 104 71 2,000 5,504E-03 0,04006154 ! regulation of peptidase activity GO:0052547 106 72 2,000 5,723E-03 0,04152163 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 5,917E-03 0,04279709 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 5,917E-03 0,04266293 ! interaction with host GO:0051701 37 23 1,000 5,917E-03 0,04252961 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 5,917E-03 0,04239712 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 5,917E-03 0,04226545 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 6,434E-03 0,04581543 ! base-excision repair GO:0006284 31 24 1,000 6,434E-03 0,04567402 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 6,434E-03 0,04553349 GO:0002708|positive regulation of lymphocyte mediated immunity, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 6,971E-03 0,04918059 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 6,971E-03 0,04903019 GO:0045936|negative regulation of phosphate metabolic process, ! iron ion homeostasis GO:0055072 39 25 1,000 6,971E-03 0,04888071 ! positive regulation of nuclear division GO:0051785 39 25 1,000 6,971E-03 0,04873214 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 6,971E-03 0,04858446 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 7,527E-03 0,05230352 ! negative regulation of protein modification process GO:0031400 50 26 1,000 7,527E-03 0,05214598 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 7,527E-03 0,05198938 ! chromatin assembly GO:0031497 102 80 2,000 7,66E-03 0,05274802 GO:0006334|nucleosome assembly, ! forebrain development GO:0030900 131 80 2,000 7,66E-03 0,05259057 ! regulation of cell cycle process GO:0010564 122 81 2,000 7,926E-03 0,05425533 ! proteoglycan metabolic process GO:0006029 41 27 1,000 8,103E-03 0,05530173 ! membrane docking GO:0022406 39 27 1,000 8,103E-03 0,05513811 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 8,103E-03 0,05497547 ! cofactor catabolic process GO:0051187 45 27 1,000 8,103E-03 0,05481377 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 8,103E-03 0,05465303 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 8,103E-03 0,05449322 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of endocytosis GO:0045807 33 28 1,000 8,698E-03 0,05832378 ! response to organic cyclic substance GO:0014070 47 28 1,000 8,698E-03 0,05815424 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 8,698E-03 0,05798567 ! myeloid leukocyte activation GO:0002274 39 28 1,000 8,698E-03 0,05781809 ! placenta development GO:0001890 37 28 1,000 8,698E-03 0,05765146 ! protein-DNA complex assembly GO:0065004 107 84 2,000 8,757E-03 0,05787478 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 9,045E-03 0,05960576 ! regulation of membrane potential GO:0042391 128 85 2,000 9,045E-03 0,05943546 ! response to hydrogen peroxide GO:0042542 42 29 1,000 9,312E-03 0,06101744 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 9,338E-03 0,0610143 ! nucleosome organization GO:0034728 114 87 2,000 9,637E-03 0,06278852 ! interphase GO:0051325 159 88 2,000 9,941E-03 0,06458868 ! collagen metabolic process GO:0032963 40 30 1,000 9,945E-03 0,06442932 ! negative regulation of cell activation GO:0050866 44 30 1,000 9,945E-03 0,06424834 ! response to heat GO:0009408 41 30 1,000 9,945E-03 0,06406837 ! positive regulation of immune effector process GO:0002699 40 30 1,000 9,945E-03 0,06388941 ! reproductive developmental process GO:0003006 127 89 2,000 0,01025097 0,06567471 ! regulation of T cell activation GO:0050863 128 89 2,000 0,01025097 0,06549228 ! negative regulation of secretion GO:0051048 49 31 1,000 0,01059585 0,0675082 ! glial cell differentiation GO:0010001 55 31 1,000 0,01059585 0,06732172 ! segmentation GO:0035282 41 31 1,000 0,01059585 0,06713626 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01059585 0,06695182 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01059585 0,06676839 ! cell fate specification GO:0001708 37 31 1,000 0,01059585 0,06658596 ! regulation of muscle development GO:0048634 48 32 1,000 0,01126557 0,07060169 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,01126557 0,07040983 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,01126557 0,07021902 ! regulation of protein stability GO:0031647 48 32 1,000 0,01126557 0,07002924 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01126557 0,06984048 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01126557 0,06965274 ! response to oxidative stress GO:0006979 141 94 2,000 0,01188457 0,07328288 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,01195349 0,07351077 ! actomyosin structure organization GO:0031032 43 33 1,000 0,01195349 0,07331475 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 0,01195349 0,07311976 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,01195349 0,07292581 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01195349 0,07273288 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,01195349 0,07254098 ! regulation of proteolysis GO:0030162 50 33 1,000 0,01195349 0,07235008 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,01257752 0,07592726 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,01265941 0,07622158 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01265941 0,07602257 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,01338314 0,0801594 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,01338314 0,0799512 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01338314 0,07974407 ! pigment metabolic process GO:0042440 61 35 1,000 0,01338314 0,07953801 ! calcium ion transport GO:0006816 167 99 2,000 0,01365962 0,080972 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,01365962 0,08076385 ! divalent metal ion transport GO:0070838 171 100 2,000 0,01403176 0,08275142 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01412447 0,08308514 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 0,01412447 0,08287319 ! glucan metabolic process GO:0044042 49 36 1,000 0,01412447 0,08266232 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,01488324 0,08688183 ! learning GO:0007612 67 37 1,000 0,01488324 0,08666188 ! gliogenesis GO:0042063 71 38 1,000 0,01565923 0,09095007 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,01565923 0,09072097 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,01645227 0,09507591 ! male sex differentiation GO:0046661 53 39 1,000 0,01645227 0,09483763 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,01645227 0,09460053 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,01726216 0,0990099 ! response to calcium ion GO:0051592 58 40 1,000 0,01726216 0,0987636 ! induction of apoptosis by intracellular signals GO:0008629 67 40 1,000 0,01726216 0,09851853 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,01808872 0,10298036 ! glucose transport GO:0015758 52 41 1,000 0,01808872 0,10272609 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01808872 0,10247307 ! cellular component disassembly GO:0022411 64 42 1,000 0,01893178 0,10698547 ! hexose transport GO:0008645 54 42 1,000 0,01893178 0,10672325 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,01893178 0,10646231 ! excretion GO:0007588 63 42 1,000 0,01893178 0,10620265 ! regulation of cell shape GO:0008360 78 42 1,000 0,01893178 0,10594424 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,01979113 0,11048447 ! regulation of translational initiation GO:0006446 64 45 1,000 0,02155803 0,1200568 ! histone modification GO:0016570 68 46 1,000 0,02246521 0,12480671 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,02246521 0,12450597 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,02338798 0,12930852 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02338798 0,12899842 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,02338798 0,12868982 ! response to temperature stimulus GO:0009266 62 48 1,000 0,02432615 0,13353258 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,02432615 0,13321464 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,02432615 0,13289822 ! heart morphogenesis GO:0003007 65 48 1,000 0,02432615 0,13258329 ! regulation of endocytosis GO:0030100 63 48 1,000 0,02432615 0,13226986 ! nuclear export GO:0051168 69 48 1,000 0,02432615 0,1319579 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,02432615 0,13164741 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,02432615 0,13133838 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02491945 0,13422656 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02491945 0,13391295 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02491945 0,1336008 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02491945 0,1332901 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02491945 0,13298084 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02491945 0,13267302 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02491945 0,13236661 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02491945 0,13206162 ! sleep GO:0030431 11 5 0,000 0,02491945 0,13175803 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02491945 0,13145583 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02491945 0,13115502 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02491945 0,13085558 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02491945 0,1305575 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02491945 0,13026078 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02491945 0,1299654 ! tongue development GO:0043586 6 5 0,000 0,02491945 0,12967136 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02491945 0,12937865 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02491945 0,12908726 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02491945 0,12879717 ! cobalt ion transport GO:0006824 9 5 0,000 0,02491945 0,12850839 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02491945 0,1282209 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02491945 0,12793469 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02491945 0,12764976 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02491945 0,12736609 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02491945 0,12708369 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02491945 0,12680253 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02491945 0,12652261 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02491945 0,12624393 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02491945 0,12596647 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02491945 0,12569023 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02491945 0,12541519 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02491945 0,12514136 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02491945 0,12486872 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02491945 0,12459727 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02491945 0,12432699 ! malate metabolic process GO:0006108 7 5 0,000 0,02491945 0,12405788 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02491945 0,12378994 ! behavioral response to pain GO:0048266 7 5 0,000 0,02491945 0,12352315 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02491945 0,12325751 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02491945 0,12299301 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02491945 0,12272964 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02491945 0,1224674 ! mating behavior GO:0007617 6 5 0,000 0,02491945 0,12220627 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02491945 0,12194626 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02491945 0,12168735 ! rhythmic behavior GO:0007622 12 5 0,000 0,02491945 0,12142954 ! copulation GO:0007620 7 5 0,000 0,02491945 0,12117282 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02491945 0,12091718 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02491945 0,12066262 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02491945 0,12040912 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02491945 0,12015669 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02491945 0,11990532 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02491945 0,119655 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02491945 0,11940571 ! response to protozoan GO:0001562 9 5 0,000 0,02491945 0,11915747 ! lymph vessel development GO:0001945 7 5 0,000 0,02491945 0,11891025 ! endochondral ossification GO:0001958 12 5 0,000 0,02491945 0,11866406 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02491945 0,11841889 ! parathyroid gland development GO:0060017 8 5 0,000 0,02491945 0,11817473 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02491945 0,11793157 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02491945 0,11768941 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02491945 0,11744824 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02491945 0,11720806 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02491945 0,11696886 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02491945 0,11673064 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02491945 0,11649338 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02491945 0,11625708 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02491945 0,11602175 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02491945 0,11578736 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02491945 0,11555392 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02491945 0,11532141 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02491945 0,11508984 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02491945 0,1148592 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02491945 0,11462949 ! ovulation GO:0030728 6 5 0,000 0,02491945 0,11440068 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02491945 0,11417279 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02491945 0,11394581 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02491945 0,11371973 ! response to pH GO:0009268 9 5 0,000 0,02491945 0,11349454 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02491945 0,11327024 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02491945 0,11304683 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02491945 0,1128243 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02491945 0,11260264 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02491945 0,11238185 ! polyol catabolic process GO:0046174 7 5 0,000 0,02491945 0,11216192 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02491945 0,11194286 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02491945 0,11172464 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02491945 0,11150728 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02491945 0,11129076 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02491945 0,11107508 ! urea metabolic process GO:0019627 6 5 0,000 0,02491945 0,11086024 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02491945 0,11064622 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02491945 0,11043303 ! neutrophil activation GO:0042119 5 5 0,000 0,02491945 0,11022066 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02491945 0,1100091 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02491945 0,10979836 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02491945 0,10958842 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02491945 0,10937928 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02491945 0,10917094 ! forebrain neuron development GO:0021884 7 5 0,000 0,02491945 0,10896339 ! melanosome organization GO:0032438 7 5 0,000 0,02491945 0,10875663 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02491945 0,10855065 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02491945 0,10834545 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02491945 0,10814102 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02491945 0,10793737 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02491945 0,10773448 ! nucleoside transport GO:0015858 6 5 0,000 0,02491945 0,10753235 ! nucleoside salvage GO:0043174 7 5 0,000 0,02491945 0,10733098 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02491945 0,10713036 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02491945 0,10693049 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02491945 0,10673136 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02491945 0,10653298 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02491945 0,10633533 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02491945 0,10613841 ! depyrimidination GO:0045008 8 5 0,000 0,02491945 0,10594222 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02491945 0,10574676 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02491945 0,10555201 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02491945 0,10535798 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02491945 0,10516467 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02491945 0,10497206 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02491945 0,10478015 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02491945 0,10458895 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02491945 0,10439844 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02491945 0,10420862 ! monocyte differentiation GO:0030224 8 5 0,000 0,02491945 0,1040195 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02491945 0,10383106 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02491945 0,1036433 ! centrosome duplication GO:0051298 5 5 0,000 0,02491945 0,10345621 ! response to UV-C GO:0010225 6 5 0,000 0,02491945 0,10326981 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02491945 0,10308407 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02491945 0,102899 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02491945 0,10271459 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02491945 0,10253085 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02491945 0,10234775 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02491945 0,10216532 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02491945 0,10198353 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02491945 0,10180238 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02491945 0,10162188 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02491945 0,10144202 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02491945 0,1012628 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02491945 0,1010842 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02491945 0,10090624 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02491945 0,1007289 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02491945 0,10055218 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02491945 0,10037608 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02491945 0,1002006 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02491945 0,10002573 ! neural tube patterning GO:0021532 6 5 0,000 0,02491945 0,09985147 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02491945 0,09967781 ! histone demethylation GO:0016577 9 5 0,000 0,02491945 0,09950476 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02491945 0,09933231 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02491945 0,09916045 ! enteric nervous system development GO:0048484 8 5 0,000 0,02491945 0,09898919 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02491945 0,09881852 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02491945 0,09864844 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02491945 0,09847894 ! transcription termination GO:0006353 8 5 0,000 0,02491945 0,09831002 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02491945 0,09814168 ! plasminogen activation GO:0031639 5 5 0,000 0,02491945 0,09797392 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02491945 0,09780673 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02491945 0,09764011 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02491945 0,09747405 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02491945 0,09730856 ! apical protein localization GO:0045176 6 5 0,000 0,02491945 0,09714363 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02491945 0,09697926 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02491945 0,09681544 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02491945 0,09665218 GO:0006681|galactosylceramide metabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02491945 0,09648947 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02491945 0,0963273 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02491945 0,09616568 ! glial cell migration GO:0008347 10 5 0,000 0,02491945 0,09600459 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02491945 0,09584405 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02491945 0,09568404 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02491945 0,09552457 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02491945 0,09536563 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02491945 0,09520721 ! neural plate development GO:0001840 6 5 0,000 0,02491945 0,09504932 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02491945 0,09489196 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02491945 0,09473511 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02491945 0,09457878 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02491945 0,09442297 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02491945 0,09426767 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02491945 0,09411288 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02491945 0,09395859 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02491945 0,09380482 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02491945 0,09365154 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02491945 0,09349876 ! spindle assembly GO:0051225 5 5 0,000 0,02491945 0,09334649 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02491945 0,0931947 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02491945 0,09304341 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02491945 0,09289261 ! organ regeneration GO:0031100 7 5 0,000 0,02491945 0,0927423 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02491945 0,09259248 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02491945 0,09244313 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02491945 0,09229427 GO:0055081|anion homeostasis, ! regulation of angiogenesis GO:0045765 94 49 1,000 0,02527956 0,09347749 ! sulfur compound biosynthetic process GO:0044272 62 49 1,000 0,02527956 0,09332744 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,02527956 0,09317788 ! germ cell development GO:0007281 68 49 1,000 0,02527956 0,0930288 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,02527956 0,09288019 ! maintenance of location GO:0051235 84 49 1,000 0,02527956 0,09273205 ! regulation of actin filament length GO:0030832 72 50 1,000 0,02624804 0,09613135 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,02624804 0,09597851 ! membrane fusion GO:0006944 80 50 1,000 0,02624804 0,09582617 ! lipid modification GO:0030258 73 50 1,000 0,02624804 0,0956743 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,02624804 0,09552292 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,0272314 0,09894505 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,0272314 0,09878899 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,0272314 0,09863342 ! regulation of cellular component size GO:0032535 74 52 1,000 0,02822948 0,10208774 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,02822948 0,10192748 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,02822948 0,10176772 ! tRNA transcription GO:0009304 11 6 0,000 0,02982917 0,10736633 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02982917 0,10719857 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02982917 0,10703134 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02982917 0,10686462 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02982917 0,10669842 ! regulation of helicase activity GO:0051095 11 6 0,000 0,02982917 0,10653274 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02982917 0,10636758 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02982917 0,10620292 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02982917 0,10603877 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02982917 0,10587513 ! prostate gland development GO:0030850 9 6 0,000 0,02982917 0,105712 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02982917 0,10554936 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02982917 0,10538723 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02982917 0,10522559 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02982917 0,10506445 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02982917 0,1049038 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02982917 0,10474364 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02982917 0,10458397 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02982917 0,10442479 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02982917 0,10426609 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02982917 0,10410787 ! neuron adhesion GO:0007158 9 6 0,000 0,02982917 0,10395013 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02982917 0,10379287 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02982917 0,10363608 ! signal peptide processing GO:0006465 8 6 0,000 0,02982917 0,10347977 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02982917 0,10332393 ! mRNA stabilization GO:0048255 15 6 0,000 0,02982917 0,10316855 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02982917 0,10301364 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02982917 0,1028592 ! opsonization GO:0008228 8 6 0,000 0,02982917 0,10270522 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02982917 0,1025517 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02982917 0,10239864 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02982917 0,10224603 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02982917 0,10209388 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02982917 0,10194218 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02982917 0,10179093 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02982917 0,10164013 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02982917 0,10148977 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02982917 0,10133986 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02982917 0,10119039 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02982917 0,10104137 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02982917 0,10089277 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02982917 0,10074462 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02982917 0,1005969 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02982917 0,10044961 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02982917 0,10030276 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02982917 0,10015633 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02982917 0,10001033 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02982917 0,09986476 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02982917 0,0997196 ! thymic T cell selection GO:0045061 12 6 0,000 0,02982917 0,09957487 ! protein lipoylation GO:0009249 10 6 0,000 0,02982917 0,09943056 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02982917 0,09928667 ! pigment granule organization GO:0048753 11 6 0,000 0,02982917 0,09914319 ! drug transport GO:0015893 6 6 0,000 0,02982917 0,09900013 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02982917 0,09885747 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,02982917 0,09871523 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02982917 0,0985734 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02982917 0,09843198 ! histidine metabolic process GO:0006547 6 6 0,000 0,02982917 0,09829096 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02982917 0,09815034 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02982917 0,09801012 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02982917 0,09787031 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02982917 0,09773089 ! adenohypophysis development GO:0021984 10 6 0,000 0,02982917 0,09759187 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02982917 0,09745325 ! hyperosmotic response GO:0006972 8 6 0,000 0,02982917 0,09731502 ! microtubule nucleation GO:0007020 10 6 0,000 0,02982917 0,09717718 ! ER overload response GO:0006983 7 6 0,000 0,02982917 0,09703973 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02982917 0,09690267 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02982917 0,09676599 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02982917 0,0966297 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02982917 0,09649379 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02982917 0,09635827 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02982917 0,09622312 ! response to dietary excess GO:0002021 7 6 0,000 0,02982917 0,09608836 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02982917 0,09595397 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02982917 0,09581995 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02982917 0,09568631 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02982917 0,09555305 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02982917 0,09542015 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02982917 0,09528762 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02982917 0,09515546 ! neuron apoptosis GO:0051402 8 6 0,000 0,02982917 0,09502367 ! organic alcohol transport GO:0015850 9 6 0,000 0,02982917 0,09489224 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02982917 0,09476117 ! carnitine transport GO:0015879 8 6 0,000 0,02982917 0,09463046 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02982917 0,09450012 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02982917 0,09437013 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02982917 0,0942405 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02982917 0,09411123 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02982917 0,09398231 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02982917 0,09385374 ! parturition GO:0007567 12 6 0,000 0,02982917 0,09372553 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02982917 0,09359766 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02982917 0,09347015 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02982917 0,09334298 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02982917 0,09321615 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02982917 0,09308967 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02982917 0,09296353 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02982917 0,09283774 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02982917 0,09271228 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02982917 0,09258716 ! astrocyte development GO:0014002 14 6 0,000 0,02982917 0,09246238 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02982917 0,09233794 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02982917 0,09221383 ! interaction with symbiont GO:0051702 8 6 0,000 0,02982917 0,09209005 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02982917 0,0919666 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02982917 0,09184349 ! eating behavior GO:0042755 6 6 0,000 0,02982917 0,0917207 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02982917 0,09159825 ! response to copper ion GO:0046688 9 6 0,000 0,02982917 0,09147612 ! DNA topological change GO:0006265 8 6 0,000 0,02982917 0,09135431 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02982917 0,09123283 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02982917 0,09111167 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02982917 0,09099083 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02982917 0,09087031 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02982917 0,09075012 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02982917 0,09063023 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02982917 0,09051067 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02982917 0,09039142 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02982917 0,09027248 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02982917 0,09015386 ! Schwann cell development GO:0014044 14 6 0,000 0,02982917 0,09003555 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02982917 0,08991755 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02982917 0,08979985 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02982917 0,08968247 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02982917 0,08956539 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02982917 0,08944861 ! histone ubiquitination GO:0016574 7 6 0,000 0,02982917 0,08933214 ! G2 phase GO:0051319 13 6 0,000 0,02982917 0,08921598 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02982917 0,08910011 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02982917 0,08898455 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02982917 0,08886928 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02982917 0,08875432 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02982917 0,08863965 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02982917 0,08852527 ! receptor internalization GO:0031623 9 6 0,000 0,02982917 0,08841119 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02982917 0,08829741 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02982917 0,08818392 ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02982917 0,08807072 ! protein deubiquitination GO:0016579 8 6 0,000 0,02982917 0,0879578 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02982917 0,08784518 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,02982917 0,08773285 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02982917 0,0876208 ! axonal fasciculation GO:0007413 9 6 0,000 0,02982917 0,08750904 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02982917 0,08739756 ! midbrain development GO:0030901 6 6 0,000 0,02982917 0,08728637 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02982917 0,08717546 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02982917 0,08706483 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02982917 0,08695448 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02982917 0,08684441 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02982917 0,08673462 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02982917 0,08662511 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02982917 0,08651587 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02982917 0,08640691 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02982917 0,08629822 ! adult feeding behavior GO:0008343 6 6 0,000 0,02982917 0,08618981 ! blastocyst growth GO:0001832 15 6 0,000 0,02982917 0,08608166 ! pigment granule transport GO:0051904 12 6 0,000 0,02982917 0,08597379 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02982917 0,08586619 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02982917 0,08575886 ! catecholamine transport GO:0051937 7 6 0,000 0,02982917 0,08565179 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02982917 0,085545 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02982917 0,08543846 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02982917 0,0853322 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02982917 0,0852262 ! protein prenylation GO:0018342 10 6 0,000 0,02982917 0,08512046 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02982917 0,08501498 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02982917 0,08490976 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02982917 0,0848048 ! regulation of mitosis GO:0007088 84 54 1,000 0,03026912 0,08594936 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,03026912 0,08584338 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,03026912 0,08573766 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,03026912 0,0856322 ! mesoderm development GO:0007498 76 55 1,000 0,03131035 0,08846904 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,03236562 0,09133856 ! carbohydrate transport GO:0008643 74 57 1,000 0,03343478 0,09424018 ! developmental maturation GO:0021700 75 57 1,000 0,03343478 0,09412484 ! gonad development GO:0008406 79 57 1,000 0,03343478 0,09400977 ! viral reproductive process GO:0022415 87 58 1,000 0,03451766 0,09693603 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,03451766 0,09681782 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03471444 0,09725118 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03471444 0,09713287 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03471444 0,09701484 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03471444 0,09689711 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03471444 0,09677965 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03471444 0,09666249 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03471444 0,0965456 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03471444 0,096429 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03471444 0,09631268 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03471444 0,09619664 ! reproductive behavior GO:0019098 12 7 0,000 0,03471444 0,09608088 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03471444 0,0959654 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03471444 0,0958502 ! oligopeptide transport GO:0006857 11 7 0,000 0,03471444 0,09573527 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03471444 0,09562062 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03471444 0,09550624 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,03471444 0,09539213 ! pericardium development GO:0060039 8 7 0,000 0,03471444 0,0952783 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03471444 0,09516474 ! fibril organization GO:0043206 13 7 0,000 0,03471444 0,09505145 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03471444 0,09493842 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03471444 0,09482567 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,03471444 0,09471319 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03471444 0,09460097 ! lipoprotein transport GO:0042953 9 7 0,000 0,03471444 0,09448901 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03471444 0,09437732 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03471444 0,0942659 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03471444 0,09415473 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03471444 0,09404383 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03471444 0,09393319 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03471444 0,09382281 ! chemosensory behavior GO:0007635 9 7 0,000 0,03471444 0,09371269 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03471444 0,09360283 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,03471444 0,09349323 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03471444 0,09338388 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03471444 0,09327478 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03471444 0,09316595 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03471444 0,09305736 ! reflex GO:0060004 12 7 0,000 0,03471444 0,09294903 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03471444 0,09284095 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03471444 0,09273312 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03471444 0,09262554 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03471444 0,09251821 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03471444 0,09241113 ! spinal cord patterning GO:0021511 7 7 0,000 0,03471444 0,0923043 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03471444 0,09219771 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03471444 0,09209137 ! adrenal gland development GO:0030325 17 7 0,000 0,03471444 0,09198527 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03471444 0,09187942 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03471444 0,09177381 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03471444 0,09166844 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03471444 0,09156332 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03471444 0,09145844 ! endosome organization GO:0007032 10 7 0,000 0,03471444 0,09135379 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03471444 0,09124939 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03471444 0,09114522 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03471444 0,09104129 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03471444 0,0909376 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03471444 0,09083415 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03471444 0,09073093 ! galactose metabolic process GO:0006012 10 7 0,000 0,03471444 0,09062794 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03471444 0,09052519 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03471444 0,09042267 ! organ growth GO:0035265 11 7 0,000 0,03471444 0,09032038 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03471444 0,09021832 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,03471444 0,0901165 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03471444 0,0900149 ! retinol metabolic process GO:0042572 9 7 0,000 0,03471444 0,08991353 ! behavioral fear response GO:0001662 13 7 0,000 0,03471444 0,08981239 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03471444 0,08971148 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03471444 0,08961079 ! rRNA modification GO:0000154 12 7 0,000 0,03471444 0,08951033 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03471444 0,0894101 ! response to UV-B GO:0010224 11 7 0,000 0,03471444 0,08931008 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03471444 0,0892103 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03471444 0,08911073 ! intermediate filament organization GO:0045109 11 7 0,000 0,03471444 0,08901139 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03471444 0,08891227 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03471444 0,08881337 ! fibrinolysis GO:0042730 9 7 0,000 0,03471444 0,08871468 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03471444 0,08861622 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03471444 0,08851798 ! B cell lineage commitment GO:0002326 17 7 0,000 0,03471444 0,08841995 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03471444 0,08832214 ! response to tropane GO:0014073 13 7 0,000 0,03471444 0,08822455 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03471444 0,08812717 ! melanosome localization GO:0032400 10 7 0,000 0,03471444 0,08803001 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03471444 0,08793306 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03471444 0,08783632 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03471444 0,0877398 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03471444 0,08764349 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03471444 0,08754739 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03471444 0,0874515 ! mast cell activation GO:0045576 9 7 0,000 0,03471444 0,08735582 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03471444 0,08726034 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03471444 0,08716508 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03471444 0,08707003 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03471444 0,08697518 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03471444 0,08688054 ! T cell lineage commitment GO:0002360 12 7 0,000 0,03471444 0,0867861 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03471444 0,08669187 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03471444 0,08659785 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03471444 0,08650403 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03471444 0,08641041 ! response to tumor cell GO:0002347 12 7 0,000 0,03471444 0,08631699 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03471444 0,08622377 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03471444 0,08613076 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03471444 0,08603795 ! diuresis GO:0030146 12 7 0,000 0,03471444 0,08594533 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03471444 0,08585292 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03471444 0,0857607 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03471444 0,08566869 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03471444 0,08557687 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03471444 0,08548524 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03471444 0,08539381 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03471444 0,08530258 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03471444 0,08521154 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03471444 0,0851207 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03471444 0,08503005 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03471444 0,08493959 ! lymph node development GO:0048535 9 7 0,000 0,03471444 0,08484933 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03471444 0,08475925 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03471444 0,08466937 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03471444 0,08457968 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03471444 0,08449017 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03471444 0,08440086 ! ATP catabolic process GO:0006200 10 7 0,000 0,03471444 0,08431174 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03471444 0,0842228 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03471444 0,08413405 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03471444 0,08404549 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03471444 0,08395711 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03471444 0,08386892 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03471444 0,08378092 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03471444 0,0836931 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03471444 0,08360546 ! retina homeostasis GO:0001895 9 7 0,000 0,03471444 0,08351801 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03471444 0,08343074 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03471444 0,08334365 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03471444 0,08325674 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03471444 0,08317002 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03471444 0,08308347 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03471444 0,08299711 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03471444 0,08291092 ! activation of MAPK activity GO:0000187 84 59 1,000 0,0356141 0,08497139 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03672393 0,08752854 ! urogenital system development GO:0001655 101 61 1,000 0,03784701 0,09011193 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03957539 0,09412968 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03957539 0,09403244 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,03957539 0,0939354 ! axon extension GO:0048675 11 8 0,000 0,03957539 0,09383856 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03957539 0,09374192 ! associative learning GO:0008306 15 8 0,000 0,03957539 0,09364548 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03957539 0,09354923 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03957539 0,09345319 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,03957539 0,09335734 ! phosphate transport GO:0006817 10 8 0,000 0,03957539 0,09326168 ! N-glycan processing GO:0006491 12 8 0,000 0,03957539 0,09316623 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03957539 0,09307097 ! UTP metabolic process GO:0046051 8 8 0,000 0,03957539 0,0929759 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03957539 0,09288102 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03957539 0,09278634 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03957539 0,09269186 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03957539 0,09259756 ! succinate metabolic process GO:0006105 14 8 0,000 0,03957539 0,09250346 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,03957539 0,09240955 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03957539 0,09231583 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03957539 0,09222229 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03957539 0,09212895 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03957539 0,0920358 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03957539 0,09194283 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03957539 0,09185005 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03957539 0,09175746 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03957539 0,09166506 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03957539 0,09157284 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03957539 0,09148081 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03957539 0,09138896 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03957539 0,0912973 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03957539 0,09120582 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03957539 0,09111452 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03957539 0,0910234 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03957539 0,09093247 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03957539 0,09084172 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03957539 0,09075115 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03957539 0,09066076 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03957539 0,09057055 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03957539 0,09048052 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03957539 0,09039067 ! melanin metabolic process GO:0006582 12 8 0,000 0,03957539 0,090301 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03957539 0,0902115 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03957539 0,09012218 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03957539 0,09003304 ! macrophage activation GO:0042116 12 8 0,000 0,03957539 0,08994407 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03957539 0,08985529 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03957539 0,08976667 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03957539 0,08967823 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03957539 0,08958996 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03957539 0,08950187 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03957539 0,08941395 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03957539 0,08932621 ! ruffle organization GO:0031529 11 8 0,000 0,03957539 0,08923863 ! osteoblast development GO:0002076 13 8 0,000 0,03957539 0,08915123 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03957539 0,089064 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03957539 0,08897693 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03957539 0,08889004 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03957539 0,08880332 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03957539 0,08871677 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03957539 0,08863038 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03957539 0,08854417 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03957539 0,08845812 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03957539 0,08837224 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03957539 0,08828652 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03957539 0,08820097 ! segment specification GO:0007379 10 8 0,000 0,03957539 0,08811559 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03957539 0,08803037 ! cellular extravasation GO:0045123 11 8 0,000 0,03957539 0,08794532 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03957539 0,08786043 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03957539 0,0877757 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03957539 0,08769114 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03957539 0,08760674 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03957539 0,0875225 GO:0016180|snRNA processing, ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03957539 0,08743843 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03957539 0,08735451 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03957539 0,08727076 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03957539 0,08718717 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03957539 0,08710374 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03957539 0,08702046 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03957539 0,08693735 ! icosanoid secretion GO:0032309 12 8 0,000 0,03957539 0,08685439 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03957539 0,0867716 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03957539 0,08668896 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03957539 0,08660647 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03957539 0,08652415 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03957539 0,08644198 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03957539 0,08635997 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03957539 0,08627811 ! sterol catabolic process GO:0016127 9 8 0,000 0,03957539 0,08619641 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03957539 0,08611486 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03957539 0,08603346 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03957539 0,08595222 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03957539 0,08587114 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03957539 0,0857902 ! prophase GO:0051324 11 8 0,000 0,03957539 0,08570942 ! S phase GO:0051320 8 8 0,000 0,03957539 0,08562879 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03957539 0,08554831 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03957539 0,08546798 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03957539 0,08538781 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03957539 0,08530778 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03957539 0,08522791 ! hormone catabolic process GO:0042447 13 8 0,000 0,03957539 0,08514818 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03957539 0,0850686 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03957539 0,08498917 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03957539 0,08490989 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03957539 0,08483076 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03957539 0,08475177 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03957539 0,08467293 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03957539 0,08459424 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03957539 0,0845157 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03957539 0,08443729 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03957539 0,08435904 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03957539 0,08428093 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03957539 0,08420296 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03957539 0,08412514 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03957539 0,08404746 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,04013225 0,08515145 ! viral reproduction GO:0016032 92 63 1,000 0,04013225 0,08507297 ! regulation of lipase activity GO:0060191 109 63 1,000 0,04013225 0,08499464 ! negative regulation of cell size GO:0045792 108 64 1,000 0,0412941 0,08737482 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,0412941 0,08729452 ! reproductive structure development GO:0048608 90 65 1,000 0,04246857 0,08969486 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,04246857 0,08961257 ! defense response to bacterium GO:0042742 73 65 1,000 0,04246857 0,08953043 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,04365549 0,09194838 ! antigen processing and presentation GO:0019882 96 66 1,000 0,04365549 0,09186426 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04441214 0,09337105 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04441214 0,09328578 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04441214 0,09320066 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04441214 0,0931157 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04441214 0,0930309 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04441214 0,09294625 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04441214 0,09286175 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04441214 0,09277741 ! GTP metabolic process GO:0046039 9 9 0,000 0,04441214 0,09269322 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04441214 0,09260918 ! social behavior GO:0035176 14 9 0,000 0,04441214 0,0925253 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04441214 0,09244156 ! artery development GO:0060840 19 9 0,000 0,04441214 0,09235798 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04441214 0,09227455 ! response to pain GO:0048265 16 9 0,000 0,04441214 0,09219127 ! protein complex disassembly GO:0043241 17 9 0,000 0,04441214 0,09210814 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04441214 0,09202516 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04441214 0,09194233 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04441214 0,09185965 ! lung alveolus development GO:0048286 17 9 0,000 0,04441214 0,09177711 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04441214 0,09169473 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04441214 0,09161249 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04441214 0,0915304 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04441214 0,09144846 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04441214 0,09136666 ! protein targeting to ER GO:0045047 19 9 0,000 0,04441214 0,09128501 ! T cell selection GO:0045058 18 9 0,000 0,04441214 0,09120351 ! endoderm development GO:0007492 12 9 0,000 0,04441214 0,09112215 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04441214 0,09104093 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04441214 0,09095986 ! arginine catabolic process GO:0006527 10 9 0,000 0,04441214 0,09087894 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04441214 0,09079816 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04441214 0,09071752 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04441214 0,09063703 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04441214 0,09055667 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04441214 0,09047646 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04441214 0,0903964 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04441214 0,09031647 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04441214 0,09023669 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04441214 0,09015704 ! mannose metabolic process GO:0006013 9 9 0,000 0,04441214 0,09007754 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04441214 0,08999817 ! receptor clustering GO:0043113 15 9 0,000 0,04441214 0,08991895 ! epithelial cell development GO:0002064 10 9 0,000 0,04441214 0,08983987 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04441214 0,08976092 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04441214 0,08968211 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04441214 0,08960345 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04441214 0,08952492 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04441214 0,08944652 ! motor axon guidance GO:0008045 14 9 0,000 0,04441214 0,08936827 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04441214 0,08929015 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04441214 0,08921216 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04441214 0,08913432 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04441214 0,08905661 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04441214 0,08897903 ! DNA ligation GO:0006266 14 9 0,000 0,04441214 0,08890159 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04441214 0,08882429 ! response to amine stimulus GO:0014075 13 9 0,000 0,04441214 0,08874711 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04441214 0,08867008 ! erythrocyte development GO:0048821 11 9 0,000 0,04441214 0,08859317 ! renal water homeostasis GO:0003091 14 9 0,000 0,04441214 0,0885164 ! postreplication repair GO:0006301 11 9 0,000 0,04441214 0,08843976 ! mRNA cleavage GO:0006379 13 9 0,000 0,04441214 0,08836326 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04441214 0,08828689 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04441214 0,08821065 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04441214 0,08813454 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04441214 0,08805856 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04441214 0,08798271 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04441214 0,087907 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04441214 0,08783141 ! acid secretion GO:0046717 14 9 0,000 0,04441214 0,08775595 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04441214 0,08768063 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04441214 0,08760543 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04441214 0,08753036 ! purine base metabolic process GO:0006144 18 9 0,000 0,04441214 0,08745542 ! oocyte differentiation GO:0009994 12 9 0,000 0,04441214 0,08738061 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,04441214 0,08730592 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04441214 0,08723136 ! spleen development GO:0048536 15 9 0,000 0,04441214 0,08715694 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04441214 0,08708263 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04441214 0,08700846 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04441214 0,08693441 ! detection of calcium ion GO:0005513 13 9 0,000 0,04441214 0,08686048 ! blastocyst formation GO:0001825 12 9 0,000 0,04441214 0,08678669 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04441214 0,08671301 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04441214 0,08663946 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04441214 0,08656604 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04441214 0,08649274 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04441214 0,08641957 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04441214 0,08634652 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04441214 0,08627359 ! prepulse inhibition GO:0060134 14 9 0,000 0,04441214 0,08620078 ! embryonic placenta development GO:0001892 12 9 0,000 0,04441214 0,0861281 ! insulin secretion GO:0030073 17 9 0,000 0,04441214 0,08605554 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04441214 0,0859831 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04441214 0,08591079 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,04485473 0,08669402 ! learning or memory GO:0007611 123 68 1,000 0,04606612 0,08896061 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,04606612 0,08888598 ! inorganic anion transport GO:0015698 93 68 1,000 0,04606612 0,08881147 ! response to metal ion GO:0010038 103 70 1,000 0,04852479 0,09347322 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,04852479 0,093395 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04922481 0,0946631 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04922481 0,09458401 ! neuron fate specification GO:0048665 11 10 0,000 0,04922481 0,09450506 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04922481 0,09442624 ! thyroid gland development GO:0030878 19 10 0,000 0,04922481 0,09434755 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,04922481 0,09426899 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04922481 0,09419057 ! synapsis GO:0007129 13 10 0,000 0,04922481 0,09411227 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04922481 0,09403411 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04922481 0,09395607 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04922481 0,09387816 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04922481 0,09380038 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,04922481 0,09372273 ! phospholipid efflux GO:0033700 16 10 0,000 0,04922481 0,09364521 ! hippocampus development GO:0021766 19 10 0,000 0,04922481 0,09356782 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,04922481 0,09349056 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04922481 0,09341342 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04922481 0,09333641 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04922481 0,09325952 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04922481 0,09318277 ! pathogenesis GO:0009405 13 10 0,000 0,04922481 0,09310614 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04922481 0,09302963 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04922481 0,09295325 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04922481 0,092877 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04922481 0,09280087 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04922481 0,09272487 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04922481 0,09264899 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04922481 0,09257323 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04922481 0,0924976 ! response to X-ray GO:0010165 16 10 0,000 0,04922481 0,09242209 ! B cell proliferation GO:0042100 14 10 0,000 0,04922481 0,09234671 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04922481 0,09227144 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04922481 0,09219631 ! forebrain cell migration GO:0021885 17 10 0,000 0,04922481 0,09212129 ! lipid digestion GO:0044241 15 10 0,000 0,04922481 0,09204639 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04922481 0,09197162 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04922481 0,09189697 ! UV protection GO:0009650 14 10 0,000 0,04922481 0,09182244 ! entry into host cell GO:0030260 20 10 0,000 0,04922481 0,09174802 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04922481 0,09167373 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04922481 0,09159957 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04922481 0,09152552 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04922481 0,09145159 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,04922481 0,09137777 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04922481 0,09130408 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04922481 0,09123051 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04922481 0,09115706 ! regulation of organ growth GO:0046620 11 10 0,000 0,04922481 0,09108372 ! response to dsRNA GO:0043331 18 10 0,000 0,04922481 0,0910105 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04922481 0,0909374 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04922481 0,09086442 ! embryonic axis specification GO:0000578 12 10 0,000 0,04922481 0,09079155 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04922481 0,0907188 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04922481 0,09064617 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04922481 0,09057365 ! cranial nerve development GO:0021545 12 10 0,000 0,04922481 0,09050125 ! fucose catabolic process GO:0019317 16 10 0,000 0,04922481 0,09042896 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,04922481 0,09035679 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04922481 0,09028474 ! protein sumoylation GO:0016925 12 10 0,000 0,04922481 0,0902128 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04922481 0,09014097 ! zymogen activation GO:0031638 14 10 0,000 0,04922481 0,09006926 ! salivary gland development GO:0007431 22 10 0,000 0,04922481 0,08999766 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04922481 0,08992618 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04922481 0,08985481 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04922481 0,08978355 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04922481 0,08971241 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04922481 0,08964138 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04922481 0,08957046 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04922481 0,08949965 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04922481 0,08942896 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04922481 0,08935838 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04922481 0,0892879 ! detection of bacterium GO:0016045 10 10 0,000 0,04922481 0,08921754 ! embryonic gut development GO:0048566 11 10 0,000 0,04922481 0,08914729 ! activation of innate immune response GO:0002218 10 10 0,000 0,04922481 0,08907715 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04922481 0,08900712 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04922481 0,08893721 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04922481 0,0888674 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04922481 0,0887977 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04922481 0,08872811 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,05103031 0,09191051 ! negative regulation of transport GO:0051051 116 73 1,000 0,05230028 0,09412413 ! regulation of blood pressure GO:0008217 107 73 1,000 0,05230028 0,09405054 ! tube morphogenesis GO:0035239 118 73 1,000 0,05230028 0,09397706 ! mitochondrion organization GO:0007005 104 73 1,000 0,05230028 0,0939037 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,05230028 0,09383045 ! protein import into nucleus GO:0006606 118 74 1,000 0,05358152 0,09605416 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,05358152 0,09597935 ! rRNA transcription GO:0009303 17 11 0,000 0,05401351 0,09667788 ! respiratory burst GO:0045730 14 11 0,000 0,05401351 0,09660271 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05401351 0,09652765 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,05401351 0,0964527 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,05401351 0,09637787 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,05401351 0,09630316 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05401351 0,09622857 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,05401351 0,09615409 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,05401351 0,09607972 ! mating GO:0007618 14 11 0,000 0,05401351 0,09600547 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,05401351 0,09593134 ! T cell proliferation GO:0042098 20 11 0,000 0,05401351 0,09585731 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,05401351 0,09578341 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,05401351 0,09570961 ! bone resorption GO:0045453 16 11 0,000 0,05401351 0,09563593 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05401351 0,09556237 ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,05401351 0,09548892 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,05401351 0,09541558 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05401351 0,09534235 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05401351 0,09526923 ! syncytium formation GO:0006949 15 11 0,000 0,05401351 0,09519623 ! plasma membrane organization GO:0007009 18 11 0,000 0,05401351 0,09512334 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05401351 0,09505056 ! focal adhesion formation GO:0048041 24 11 0,000 0,05401351 0,09497789 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05401351 0,09490533 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05401351 0,09483288 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,05401351 0,09476055 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,05401351 0,09468832 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05401351 0,09461621 ! adult heart development GO:0007512 11 11 0,000 0,05401351 0,0945442 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,05401351 0,0944723 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,05401351 0,09440052 ! temperature homeostasis GO:0001659 16 11 0,000 0,05401351 0,09432884 ! L-glutamate transport GO:0015813 16 11 0,000 0,05401351 0,09425727 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,05401351 0,09418581 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05401351 0,09411445 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05401351 0,09404321 ! protein homotetramerization GO:0051289 18 11 0,000 0,05401351 0,09397207 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,05401351 0,09390104 ! vasoconstriction GO:0042310 15 11 0,000 0,05401351 0,09383012 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05401351 0,09375931 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05401351 0,0936886 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,05401351 0,09361799 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05401351 0,0935475 ! ribosome assembly GO:0042255 13 11 0,000 0,05401351 0,09347711 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05401351 0,09340683 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,05401351 0,09333665 ! chromatin silencing GO:0006342 19 11 0,000 0,05401351 0,09326658 ! nucleosome positioning GO:0016584 13 11 0,000 0,05401351 0,09319661 ! regulation of isotype switching GO:0045191 19 11 0,000 0,05401351 0,09312675 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,05401351 0,09305699 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,05401351 0,09298733 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,05401351 0,09291779 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05401351 0,09284834 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05401351 0,092779 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,05401351 0,09270976 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,05401351 0,09264063 ! male genitalia development GO:0030539 13 11 0,000 0,05401351 0,09257159 ! cholesterol efflux GO:0033344 19 11 0,000 0,05401351 0,09250267 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,05401351 0,09243384 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05401351 0,09236511 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05401351 0,09229649 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,05401351 0,09222797 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,05401351 0,09215955 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05401351 0,09209124 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,05401351 0,09202302 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,05401351 0,09195491 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05401351 0,09188689 ! lysogeny GO:0030069 18 11 0,000 0,05401351 0,09181898 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05401351 0,09175117 ! acrosome reaction GO:0007340 13 11 0,000 0,05401351 0,09168345 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,05401351 0,09161584 ! blood coagulation GO:0007596 116 75 1,000 0,0548739 0,0930066 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,0548739 0,09293811 ! response to nutrient GO:0007584 104 75 1,000 0,0548739 0,09286973 ! nuclear import GO:0051170 121 75 1,000 0,0548739 0,09280144 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,05617727 0,09493586 ! sex differentiation GO:0007548 105 77 1,000 0,05749149 0,09708548 ! protein ubiquitination GO:0016567 125 77 1,000 0,05749149 0,09701425 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,05749149 0,09694313 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,05749149 0,09687211 ! lactation GO:0007595 20 12 0,000 0,05877837 0,09896797 ! reproductive cellular process GO:0048610 14 12 0,000 0,05877837 0,09889557 ! tRNA modification GO:0006400 14 12 0,000 0,05877837 0,09882328 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05877837 0,0987511 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05877837 0,09867901 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05877837 0,09860704 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05877837 0,09853517 ! non-recombinational repair GO:0000726 19 12 0,000 0,05877837 0,0984634 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05877837 0,09839174 ! peroxisomal transport GO:0043574 21 12 0,000 0,05877837 0,09832018 ! cartilage condensation GO:0001502 18 12 0,000 0,05877837 0,09824873 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05877837 0,09817738 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05877837 0,09810613 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05877837 0,09803499 ! heart looping GO:0001947 15 12 0,000 0,05877837 0,09796395 ! palate development GO:0060021 15 12 0,000 0,05877837 0,09789301 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,05877837 0,09782218 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05877837 0,09775145 ! arginine metabolic process GO:0006525 13 12 0,000 0,05877837 0,09768082 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05877837 0,09761029 ! methionine metabolic process GO:0006555 13 12 0,000 0,05877837 0,09753986 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05877837 0,09746954 ! Golgi organization GO:0007030 18 12 0,000 0,05877837 0,09739932 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05877837 0,09732919 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05877837 0,09725917 ! monoamine transport GO:0015844 13 12 0,000 0,05877837 0,09718925 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05877837 0,09711943 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05877837 0,09704971 ! L-amino acid transport GO:0015807 20 12 0,000 0,05877837 0,09698009 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05877837 0,09691057 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05877837 0,09684115 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05877837 0,09677183 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05877837 0,09670261 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05877837 0,09663349 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05877837 0,09656446 ! cerebellum development GO:0021549 13 12 0,000 0,05877837 0,09649554 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05877837 0,09642671 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05877837 0,09635798 ! histone methylation GO:0016571 15 12 0,000 0,05877837 0,09628935 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05877837 0,09622082 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05877837 0,09615238 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05877837 0,09608404 ! response to gamma radiation GO:0010332 20 12 0,000 0,05877837 0,0960158 ! regulation of epidermis development GO:0045682 17 12 0,000 0,05877837 0,09594766 ! intestinal absorption GO:0050892 19 12 0,000 0,05877837 0,09587961 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05877837 0,09581166 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05877837 0,0957438 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,05877837 0,09567604 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05877837 0,09560838 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,05877837 0,09554081 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05877837 0,09547334 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05877837 0,09540596 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05877837 0,09533868 ! response to cold GO:0009409 14 12 0,000 0,05877837 0,09527149 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,05881642 0,09526604 ! T cell activation GO:0042110 134 79 1,000 0,06015194 0,09736063 ! protein localization in nucleus GO:0034504 133 80 1,000 0,06149788 0,09946915 ! hemostasis GO:0007599 125 81 1,000 0,06285414 0,10159136 ! regulation of neurological system process GO:0031644 122 81 1,000 0,06285414 0,10152002 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,06285414 0,10144878 GO:0002696|positive regulation of leukocyte activation, ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,0635195 0,1024508 ! cGMP metabolic process GO:0046068 16 13 0,000 0,0635195 0,10237901 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,0635195 0,10230731 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,0635195 0,10223572 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,0635195 0,10216423 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,0635195 0,10209283 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,0635195 0,10202154 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,0635195 0,10195034 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,0635195 0,10187925 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,0635195 0,10180825 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,0635195 0,10173736 ! response to hexose stimulus GO:0009746 19 13 0,000 0,0635195 0,10166656 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,0635195 0,10159586 ! glutamate metabolic process GO:0006536 18 13 0,000 0,0635195 0,10152526 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,0635195 0,10145475 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,0635195 0,10138435 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,0635195 0,10131404 ! NAD metabolic process GO:0019674 21 13 0,000 0,0635195 0,10124383 ! exocrine system development GO:0035272 27 13 0,000 0,0635195 0,10117371 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,0635195 0,1011037 ! bone mineralization GO:0030282 15 13 0,000 0,0635195 0,10103378 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,0635195 0,10096396 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,0635195 0,10089423 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,0635195 0,1008246 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,0635195 0,10075506 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,0635195 0,10068563 ! genitalia development GO:0048806 15 13 0,000 0,0635195 0,10061628 ! regulation of cellular pH GO:0030641 20 13 0,000 0,0635195 0,10054704 ! cellular pigmentation GO:0033059 24 13 0,000 0,0635195 0,10047788 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,0635195 0,10040883 ! cofactor transport GO:0051181 19 13 0,000 0,0635195 0,10033987 ! NADP metabolic process GO:0006739 18 13 0,000 0,0635195 0,100271 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,0635195 0,10020222 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,0635195 0,10013355 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0635195 0,10006496 ! gas transport GO:0015669 18 13 0,000 0,0635195 0,09999647 ! regulation of RNA stability GO:0043487 28 13 0,000 0,0635195 0,09992807 ! heme biosynthetic process GO:0006783 20 13 0,000 0,0635195 0,09985977 ! regulation of axon extension GO:0030516 23 13 0,000 0,0635195 0,09979156 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,0635195 0,09972344 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,0635195 0,09965542 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,0635195 0,09958749 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,0635195 0,09951965 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,0635195 0,0994519 ! ossification GO:0001503 134 82 1,000 0,06422055 0,10048114 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,065597 0,10256499 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,06823701 0,10662033 ! superoxide anion generation GO:0042554 18 14 0,000 0,06823701 0,10654795 ! neuron maturation GO:0042551 21 14 0,000 0,06823701 0,10647566 ! regulation of S phase GO:0033261 18 14 0,000 0,06823701 0,10640348 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,06823701 0,10633139 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,06823701 0,1062594 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,06823701 0,1061875 ! inositol metabolic process GO:0006020 20 14 0,000 0,06823701 0,10611571 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,06823701 0,10604401 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,06823701 0,1059724 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,06823701 0,1059009 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,06823701 0,10582949 ! gene silencing by RNA GO:0031047 20 14 0,000 0,06823701 0,10575817 ! response to cAMP GO:0051591 19 14 0,000 0,06823701 0,10568696 ! limbic system development GO:0021761 25 14 0,000 0,06823701 0,10561583 ! startle response GO:0001964 21 14 0,000 0,06823701 0,10554481 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,06823701 0,10547388 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,06823701 0,10540304 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,06823701 0,1053323 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,06823701 0,10526166 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,06823701 0,10519111 ! glycine metabolic process GO:0006544 22 14 0,000 0,06823701 0,10512065 ! pituitary gland development GO:0021983 23 14 0,000 0,06823701 0,10505029 ! cellular response to starvation GO:0009267 21 14 0,000 0,06823701 0,10498002 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,06823701 0,10490985 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,06823701 0,10483977 ! regulation of heart rate GO:0002027 23 14 0,000 0,06823701 0,10476978 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,06823701 0,10469989 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,06823701 0,10463009 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,06823701 0,10456038 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,06823701 0,10449077 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,06823701 0,10442124 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,06823701 0,10435182 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,06823701 0,10428248 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,06823701 0,10421323 ! axon cargo transport GO:0008088 27 14 0,000 0,06823701 0,10414408 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,06823701 0,10407502 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,06823701 0,10400605 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,06823701 0,10393717 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,06823701 0,10386839 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06823701 0,10379969 ! mRNA splice site selection GO:0006376 26 14 0,000 0,06823701 0,10373108 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,06823701 0,10366257 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,06823701 0,10359415 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,06823701 0,10352581 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,06823701 0,10345757 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,06823701 0,10338941 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,06823701 0,10332135 ! muscle maintenance GO:0046716 19 14 0,000 0,06823701 0,10325338 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,06823701 0,10318549 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,06823701 0,10311769 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,06823701 0,10304999 ! cell killing GO:0001906 20 14 0,000 0,06823701 0,10298237 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,06823701 0,10291484 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,06823701 0,1028474 ! cilium assembly GO:0042384 20 14 0,000 0,06823701 0,10278005 ! peptide hormone secretion GO:0030072 23 14 0,000 0,06823701 0,10271278 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,06837947 0,10285989 ! cell cycle arrest GO:0007050 150 86 1,000 0,06978522 0,10490589 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,07120048 0,10696349 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,07262512 0,10903249 ! positive regulation of cell size GO:0045793 20 15 0,000 0,07293103 0,10942034 ! metencephalon development GO:0022037 19 15 0,000 0,07293103 0,10934901 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,07293103 0,10927777 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,07293103 0,10920663 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,07293103 0,10913557 ! skin development GO:0043588 25 15 0,000 0,07293103 0,10906461 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,07293103 0,10899375 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,07293103 0,10892297 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,07293103 0,10885229 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,07293103 0,1087817 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,07293103 0,1087112 ! bile acid metabolic process GO:0008206 22 15 0,000 0,07293103 0,10864079 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,07293103 0,10857047 ! adult walking behavior GO:0007628 25 15 0,000 0,07293103 0,10850024 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,07293103 0,10843011 ! centrosome cycle GO:0007098 16 15 0,000 0,07293103 0,10836006 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,07293103 0,10829011 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,07293103 0,10822024 ! cerebral cortex development GO:0021987 29 15 0,000 0,07293103 0,10815047 ! response to osmotic stress GO:0006970 22 15 0,000 0,07293103 0,10808078 ! vesicle coating GO:0006901 25 15 0,000 0,07293103 0,10801119 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,07293103 0,10794168 ! DNA integration GO:0015074 22 15 0,000 0,07293103 0,10787227 ! peptide secretion GO:0002790 27 15 0,000 0,07293103 0,10780294 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,07293103 0,1077337 ! neuron recognition GO:0008038 22 15 0,000 0,07293103 0,10766455 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,07293103 0,10759549 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,07293103 0,10752652 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,07293103 0,10745764 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,07293103 0,10738885 ! biomineral formation GO:0031214 18 15 0,000 0,07293103 0,10732014 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,07293103 0,10725152 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,07293103 0,10718299 ! dopamine metabolic process GO:0042417 30 15 0,000 0,07293103 0,10711454 ! organic cation transport GO:0015695 19 15 0,000 0,07293103 0,10704619 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,07293103 0,10697792 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,07293103 0,10690974 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,07293103 0,10684164 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,07293103 0,10677363 ! defense response to virus GO:0051607 27 15 0,000 0,07293103 0,10670571 ! peptide hormone processing GO:0016486 19 15 0,000 0,07293103 0,10663787 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,07293103 0,10657012 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,07405901 0,10814966 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,07550202 0,11018696 ! protein secretion GO:0009306 27 16 0,000 0,07760167 0,11317936 ! hormone secretion GO:0046879 25 16 0,000 0,07760167 0,11310764 ! bone remodeling GO:0046849 24 16 0,000 0,07760167 0,113036 ! endothelial cell migration GO:0043542 22 16 0,000 0,07760167 0,11296446 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,07760167 0,11289301 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,07760167 0,11282165 ! glial cell development GO:0021782 24 16 0,000 0,07760167 0,11275038 ! patterning of blood vessels GO:0001569 24 16 0,000 0,07760167 0,1126792 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,07760167 0,11260811 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,07760167 0,1125371 ! protein polyubiquitination GO:0000209 26 16 0,000 0,07760167 0,11246619 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,07760167 0,11239537 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,07760167 0,11232464 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,07760167 0,11225399 ! fructose metabolic process GO:0006000 20 16 0,000 0,07760167 0,11218344 ! regulation of protein binding GO:0043393 27 16 0,000 0,07760167 0,11211297 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,07760167 0,11204259 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,07760167 0,1119723 ! negative regulation of immune response GO:0050777 28 16 0,000 0,07760167 0,1119021 ! DNA replication initiation GO:0006270 25 16 0,000 0,07760167 0,11183199 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,07760167 0,11176196 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,07760167 0,11169202 ! diencephalon development GO:0021536 25 16 0,000 0,07760167 0,11162217 ! oogenesis GO:0048477 23 16 0,000 0,07760167 0,11155241 ! neural crest cell migration GO:0001755 24 16 0,000 0,07760167 0,11148273 ! G1 phase GO:0051318 27 16 0,000 0,07760167 0,11141314 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,07760167 0,11134364 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,07760167 0,11127422 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,07760167 0,11120489 ! steroid catabolic process GO:0006706 22 16 0,000 0,07760167 0,11113565 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,07760167 0,11106649 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,07760167 0,11099742 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,07760167 0,11092843 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,07760167 0,11085953 ! sperm-egg recognition GO:0035036 16 16 0,000 0,07760167 0,11079072 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,07760167 0,11072199 ! nerve development GO:0021675 18 16 0,000 0,07760167 0,11065335 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,07760167 0,11058479 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,07841491 0,11167449 ! cell fate commitment GO:0045165 141 92 1,000 0,07841491 0,11160538 ! positive regulation of immune response GO:0050778 121 92 1,000 0,07841491 0,11153636 ! sulfur metabolic process GO:0006790 118 92 1,000 0,07841491 0,11146743 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,07988455 0,11348638 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,08224905 0,11677334 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,08224905 0,1167013 ! negative regulation of defense response GO:0031348 19 17 0,000 0,08224905 0,11662935 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,08224905 0,11655749 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,08224905 0,11648572 ! glycerol metabolic process GO:0006071 20 17 0,000 0,08224905 0,11641404 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,08224905 0,11634244 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,08224905 0,11627093 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,08224905 0,11619952 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,08224905 0,11612818 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,08224905 0,11605694 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,08224905 0,11598578 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,08224905 0,11591471 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,08224905 0,11584373 ! memory GO:0007613 25 17 0,000 0,08224905 0,11577283 ! keratinization GO:0031424 17 17 0,000 0,08224905 0,11570202 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,08224905 0,1156313 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,08224905 0,11556067 ! retinoid metabolic process GO:0001523 22 17 0,000 0,08224905 0,11549012 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,08224905 0,11541965 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,08224905 0,11534927 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,08224905 0,11527898 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,08224905 0,11520878 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,08224905 0,11513866 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,08224905 0,11506862 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,08224905 0,11499867 ! membrane budding GO:0006900 29 17 0,000 0,08224905 0,1149288 ! actin filament bundle formation GO:0051017 26 17 0,000 0,08224905 0,11485902 ! neuromuscular junction development GO:0007528 23 17 0,000 0,08224905 0,11478933 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,08224905 0,11471972 ! body fluid secretion GO:0007589 27 17 0,000 0,08224905 0,11465019 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,08224905 0,11458075 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,08224905 0,11451139 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,08224905 0,11444211 ! sensory perception of pain GO:0019233 23 17 0,000 0,08224905 0,11437292 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,08224905 0,11430381 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,08224905 0,11423479 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,08224905 0,11416585 ! synaptogenesis GO:0007416 24 17 0,000 0,08224905 0,11409699 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,08224905 0,11402822 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,08224905 0,11395952 ! cell-cell junction organization GO:0045216 25 17 0,000 0,08224905 0,11389092 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,08224905 0,11382239 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,08224905 0,11375395 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,08224905 0,11368558 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,08224905 0,1136173 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,08224905 0,11354911 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,08224905 0,11348099 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,08434472 0,11630267 ! protein maturation GO:0051604 129 96 1,000 0,08434472 0,11623299 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,08584814 0,11823396 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,08687327 0,11957422 ! positive regulation of translation GO:0045727 28 18 0,000 0,08687327 0,11950271 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,08687327 0,11943128 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,08687327 0,11935993 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,08687327 0,11928867 ! cAMP metabolic process GO:0046058 33 18 0,000 0,08687327 0,1192175 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,08687327 0,11914641 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,08687327 0,1190754 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,08687327 0,11900448 ! axis specification GO:0009798 26 18 0,000 0,08687327 0,11893365 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,08687327 0,1188629 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,08687327 0,11879223 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,08687327 0,11872164 ! glutamine metabolic process GO:0006541 23 18 0,000 0,08687327 0,11865114 ! response to retinoic acid GO:0032526 25 18 0,000 0,08687327 0,11858073 ! pigmentation during development GO:0048066 31 18 0,000 0,08687327 0,1185104 ! central nervous system neuron development GO:0021954 30 18 0,000 0,08687327 0,11844015 ! fucose metabolic process GO:0006004 26 18 0,000 0,08687327 0,11836998 ! response to fungus GO:0009620 19 18 0,000 0,08687327 0,1182999 ! peptide cross-linking GO:0018149 31 18 0,000 0,08687327 0,1182299 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,08687327 0,11815998 ! heart process GO:0003015 27 18 0,000 0,08687327 0,11809015 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,08687327 0,11802039 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,08687327 0,11795072 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,08687327 0,11788114 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,08687327 0,11781163 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,08687327 0,11774221 ! vitamin transport GO:0051180 24 18 0,000 0,08687327 0,11767287 ! hormone transport GO:0009914 27 18 0,000 0,08687327 0,11760361 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,08687327 0,11753443 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,08687327 0,11746533 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,08687327 0,11739631 ! cell-cell recognition GO:0009988 20 18 0,000 0,08687327 0,11732738 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,08687327 0,11725853 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,08687327 0,11718975 ! regulation of glucose import GO:0046324 21 18 0,000 0,08687327 0,11712106 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,08687327 0,11705245 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,08687327 0,11698392 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,08687327 0,11691546 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,08687327 0,11684709 ! protein import GO:0017038 156 99 1,000 0,08887929 0,11947537 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,09040679 0,12145772 ! protein localization in organelle GO:0033365 161 100 1,000 0,09040679 0,12138681 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,09147446 0,12274869 ! positive regulation of ossification GO:0045778 30 19 0,000 0,09147446 0,12267712 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,09147446 0,12260563 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,09147446 0,12253422 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,09147446 0,1224629 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,09147446 0,12239166 ! sensory perception of taste GO:0050909 23 19 0,000 0,09147446 0,1223205 ! smooth muscle contraction GO:0006939 36 19 0,000 0,09147446 0,12224943 ! peroxisome organization GO:0007031 29 19 0,000 0,09147446 0,12217843 ! digestive system process GO:0022600 30 19 0,000 0,09147446 0,12210752 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,09147446 0,12203669 ! response to vitamin A GO:0033189 26 19 0,000 0,09147446 0,12196595 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,09147446 0,12189528 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,09147446 0,1218247 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,09147446 0,1217542 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,09147446 0,12168378 ! response to starvation GO:0042594 30 19 0,000 0,09147446 0,12161345 ! plasma membrane fusion GO:0045026 23 19 0,000 0,09147446 0,12154319 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,09147446 0,12147301 ! cytolysis GO:0019835 20 19 0,000 0,09147446 0,12140292 ! renal system process GO:0003014 35 19 0,000 0,09147446 0,12133291 ! vasodilation GO:0042311 33 19 0,000 0,09147446 0,12126297 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,09147446 0,12119312 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,09147446 0,12112335 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,09147446 0,12105366 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,09147446 0,12098405 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,09147446 0,12091452 ! sarcomere organization GO:0045214 23 19 0,000 0,09147446 0,12084507 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,09147446 0,12077569 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,09147446 0,1207064 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,09147446 0,12063719 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,09147446 0,12056806 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,09147446 0,120499 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,09147446 0,12043003 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,09147446 0,12036113 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,09605273 0,12631291 ! iron ion transport GO:0006826 37 20 0,000 0,09605273 0,12624073 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,09605273 0,12616863 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,09605273 0,12609662 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,09605273 0,12602468 ! response to vitamin GO:0033273 29 20 0,000 0,09605273 0,12595283 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,09605273 0,12588107 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,09605273 0,12580938 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,09605273 0,12573778 ! spinal cord development GO:0021510 31 20 0,000 0,09605273 0,12566625 ! response to ethanol GO:0045471 37 20 0,000 0,09605273 0,12559481 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,09605273 0,12552345 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,09605273 0,12545217 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,09605273 0,12538097 ! chromosome condensation GO:0030261 31 20 0,000 0,09605273 0,12530985 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,09605273 0,12523882 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,09605273 0,12516786 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,09605273 0,12509698 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,09605273 0,12502619 ! pallium development GO:0021543 38 20 0,000 0,09605273 0,12495547 ! DNA modification GO:0006304 28 20 0,000 0,09605273 0,12488483 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,09605273 0,12481428 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,09605273 0,1247438 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,09605273 0,1246734 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,09605273 0,12460309 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,09605273 0,12453285 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,09605273 0,12446269 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,09605273 0,12439261 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,09605273 0,12432261 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,09605273 0,12425268 ! alditol metabolic process GO:0019400 24 20 0,000 0,09605273 0,12418284 ! actin filament-based movement GO:0030048 34 20 0,000 0,09605273 0,12411307 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,10060818 0,12992634 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,10060818 0,12985343 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,10060818 0,1297806 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,10060818 0,12970786 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,10060818 0,12963519 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,10060818 0,12956261 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,10060818 0,12949011 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,10060818 0,12941768 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,10060818 0,12934534 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,10060818 0,12927308 ! phototransduction GO:0007602 25 21 0,000 0,10060818 0,1292009 ! dendrite development GO:0016358 35 21 0,000 0,10060818 0,1291288 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,10060818 0,12905679 ! ovarian follicle development GO:0001541 30 21 0,000 0,10060818 0,12898485 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,10060818 0,12891299 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,10060818 0,12884121 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,10060818 0,12876951 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,10060818 0,1286979 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,10060818 0,12862636 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,10060818 0,1285549 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,10060818 0,12848352 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,10060818 0,12841222 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,10060818 0,128341 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,10060818 0,12826985 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,10060818 0,12819879 ! fatty acid transport GO:0015908 30 21 0,000 0,10060818 0,12812781 ! immunoglobulin production GO:0002377 33 21 0,000 0,10060818 0,1280569 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,10060818 0,12798607 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,10060818 0,12791532 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,10060818 0,12784465 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,10060818 0,12777406 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,10060818 0,12770354 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,10060818 0,1276331 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,10060818 0,12756274 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,10060818 0,12749246 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,10060818 0,12742226 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,10060818 0,12735213 ! viral genome replication GO:0019079 29 22 0,000 0,10514094 0,13301659 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,10514094 0,13294346 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,10514094 0,13287042 ! leukocyte adhesion GO:0007159 38 22 0,000 0,10514094 0,13279745 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,10514094 0,13272457 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,10514094 0,13265176 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,10514094 0,13257904 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,10514094 0,13250639 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,10514094 0,13243382 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,10514094 0,13236134 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,10514094 0,13228893 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,10514094 0,1322166 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,10514094 0,13214435 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,10514094 0,13207218 ! regulation of behavior GO:0050795 38 22 0,000 0,10514094 0,13200009 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,10514094 0,13192807 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,10514094 0,13185614 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,10514094 0,13178428 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,10514094 0,13171251 ! blastocyst development GO:0001824 37 22 0,000 0,10514094 0,13164081 ! neural tube closure GO:0001843 33 22 0,000 0,10514094 0,13156918 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,10514094 0,13149764 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,10965111 0,13706389 ! neuron fate commitment GO:0048663 32 23 0,000 0,10965111 0,13698944 ! embryonic pattern specification GO:0009880 31 23 0,000 0,10965111 0,13691507 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,10965111 0,13684078 ! myelination GO:0042552 35 23 0,000 0,10965111 0,13676657 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,10965111 0,13669244 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,10965111 0,13661839 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,10965111 0,13654443 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,10965111 0,13647054 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,10965111 0,13639673 ! vesicle targeting GO:0006903 32 23 0,000 0,10965111 0,136323 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,10965111 0,13624935 ! osteoblast differentiation GO:0001649 40 23 0,000 0,10965111 0,13617579 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,10965111 0,1361023 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,10965111 0,13602889 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,10965111 0,13595556 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,10965111 0,1358823 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,10965111 0,13580913 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,10965111 0,13573604 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,10965111 0,13566302 ! cell fate determination GO:0001709 45 23 0,000 0,10965111 0,13559008 ! pentose metabolic process GO:0019321 31 23 0,000 0,10965111 0,13551722 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,10965111 0,13544444 ! spermatid development GO:0007286 33 23 0,000 0,10965111 0,13537174 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,10965111 0,13529912 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,10965111 0,13522657 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,10965111 0,1351541 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,10965111 0,13508171 ! telomere organization GO:0032200 32 23 0,000 0,10965111 0,1350094 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,10965111 0,13493716 ! regulation of amine transport GO:0051952 38 23 0,000 0,10965111 0,134865 ! liver development GO:0001889 40 23 0,000 0,10965111 0,13479292 ! initiation of viral infection GO:0019059 42 24 0,000 0,11413881 0,14023465 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,11413881 0,14015977 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,11413881 0,14008498 ! superoxide metabolic process GO:0006801 32 24 0,000 0,11413881 0,14001027 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,11413881 0,13993564 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,11413881 0,13986109 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,11413881 0,13978661 ! sperm motility GO:0030317 27 24 0,000 0,11413881 0,13971222 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,11413881 0,1396379 ! vacuole organization GO:0007033 39 24 0,000 0,11413881 0,13956367 ! receptor metabolic process GO:0043112 37 24 0,000 0,11413881 0,13948951 ! neural crest cell development GO:0014032 39 24 0,000 0,11413881 0,13941543 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,11413881 0,13934143 ! primary neural tube formation GO:0014020 35 24 0,000 0,11413881 0,13926751 ! negative regulation of cell development GO:0010721 56 24 0,000 0,11413881 0,13919367 GO:0050768|negative regulation of neurogenesis, ! glutathione metabolic process GO:0006749 29 24 0,000 0,11413881 0,1391199 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,11413881 0,13904622 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,11413881 0,13897261 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,11413881 0,13889908 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,11860414 0,14425676 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,11860414 0,14418051 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,11860414 0,14410434 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,11860414 0,14402826 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,11860414 0,14395226 ! peptide transport GO:0015833 43 25 0,000 0,11860414 0,14387633 ! male gonad development GO:0008584 33 25 0,000 0,11860414 0,14380049 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,11860414 0,14372472 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,11860414 0,14364904 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,11860414 0,14357343 ! phospholipid transport GO:0015914 35 25 0,000 0,11860414 0,14349791 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,11860414 0,14342246 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,11860414 0,1433471 ! detection of light stimulus GO:0009583 30 25 0,000 0,11860414 0,14327181 ! leukocyte proliferation GO:0070661 39 25 0,000 0,11860414 0,1431966 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,11860414 0,14312147 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,12304722 0,14840514 ! translational initiation GO:0006413 43 26 0,000 0,12304722 0,14832736 ! regulation of pH GO:0006885 36 26 0,000 0,12304722 0,14824966 ! circadian rhythm GO:0007623 42 26 0,000 0,12304722 0,14817205 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,12304722 0,14809451 ! post-embryonic development GO:0009791 42 26 0,000 0,12304722 0,14801705 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,12304722 0,14793968 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,12304722 0,14786239 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,12304722 0,14778517 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,12304722 0,14770804 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,12746816 0,15293519 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,12746816 0,15285545 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,12746816 0,1527758 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inner ear morphogenesis GO:0042472 35 27 0,000 0,12746816 0,15269623 ! catechol metabolic process GO:0009712 43 27 0,000 0,12746816 0,15261674 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,12746816 0,15253733 ! acute-phase response GO:0006953 42 27 0,000 0,12746816 0,15245801 ! myofibril assembly GO:0030239 36 27 0,000 0,12746816 0,15237877 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,12746816 0,15229961 ! response to ionizing radiation GO:0010212 47 27 0,000 0,12746816 0,15222054 ! natural killer cell activation GO:0030101 35 27 0,000 0,12746816 0,15214155 ! lipid oxidation GO:0034440 38 27 0,000 0,12746816 0,15206263 GO:0019395|fatty acid oxidation, ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,12746816 0,1519838 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,12746816 0,15190506 ! gene silencing GO:0016458 41 27 0,000 0,12746816 0,15182639 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,13186706 0,15698459 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,13186706 0,15690338 ! phenol metabolic process GO:0018958 44 28 0,000 0,13186706 0,15682225 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,13186706 0,1567412 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,13186706 0,15666024 ! cell junction assembly GO:0034329 56 28 0,000 0,13186706 0,15657936 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,13186706 0,15649857 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,13186706 0,15641786 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,13186706 0,15633723 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,13186706 0,15625669 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,13186706 0,15617622 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,13186706 0,15609585 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,13186706 0,15601555 ! mesoderm formation GO:0001707 46 28 0,000 0,13186706 0,15593534 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,13186706 0,1558552 ! ensheathment of neurons GO:0007272 43 28 0,000 0,13186706 0,15577516 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,13186706 0,15569519 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,13186706 0,1556153 ! neural tube formation GO:0001841 41 28 0,000 0,13186706 0,1555355 ! regulation of B cell activation GO:0050864 42 28 0,000 0,13186706 0,15545578 ! regulation of innate immune response GO:0045088 38 29 0,000 0,13624403 0,16053344 ! ovulation cycle process GO:0022602 41 29 0,000 0,13624403 0,16045124 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,13624403 0,16036912 ! protein targeting to membrane GO:0006612 53 29 0,000 0,13624403 0,16028709 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,13624403 0,16020515 ! mismatch repair GO:0006298 34 29 0,000 0,13624403 0,16012328 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,13624403 0,16004151 ! muscle cell development GO:0055001 38 29 0,000 0,13624403 0,15995981 ! formation of primary germ layer GO:0001704 48 29 0,000 0,13624403 0,1598782 ! telencephalon development GO:0021537 52 29 0,000 0,13624403 0,15979667 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,13624403 0,15971522 ! eye morphogenesis GO:0048592 51 29 0,000 0,13624403 0,15963386 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,13624403 0,15955258 ! tissue homeostasis GO:0001894 42 29 0,000 0,13624403 0,15947138 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,14059918 0,16448531 ! organic anion transport GO:0015711 51 30 0,000 0,14059918 0,16440169 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,14059918 0,16431815 ! spliceosome assembly GO:0000245 49 30 0,000 0,14059918 0,1642347 ! spindle organization GO:0007051 37 30 0,000 0,14059918 0,16415133 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,14059918 0,16406805 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,14059918 0,16398485 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,14059918 0,16390174 ! ceramide metabolic process GO:0006672 43 30 0,000 0,14059918 0,16381871 ! ovulation cycle GO:0042698 43 30 0,000 0,14059918 0,16373576 ! hindbrain development GO:0030902 45 30 0,000 0,14059918 0,1636529 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,14059918 0,16357012 ! adult locomotory behavior GO:0008344 47 30 0,000 0,14059918 0,16348742 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,14059918 0,16340481 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,14059918 0,16332229 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,14493263 0,1682711 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,14493263 0,1681862 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,14493263 0,16810139 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,14493263 0,16801666 ! odontogenesis GO:0042476 50 31 0,000 0,14493263 0,16793201 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,14493263 0,16784746 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,14493263 0,16776298 ! metanephros development GO:0001656 58 31 0,000 0,14493263 0,1676786 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,14493263 0,16759429 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,14493263 0,16751007 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,14493263 0,16742594 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,14493263 0,16734189 ! RNA modification GO:0009451 40 31 0,000 0,14493263 0,16725793 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,14924447 0,17214758 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,14924447 0,17206129 ! meiosis I GO:0007127 52 32 0,000 0,14924447 0,17197509 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,14924447 0,17188897 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,14924447 0,17180294 ! peripheral nervous system development GO:0007422 53 32 0,000 0,14924447 0,171717 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,14924447 0,17163114 ! cytokine production GO:0001816 44 32 0,000 0,14924447 0,17154537 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,14924447 0,17145968 ! vesicle localization GO:0051648 47 32 0,000 0,14924447 0,17137408 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,15353481 0,17621261 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,15353481 0,17612472 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,15353481 0,17603692 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,15353481 0,17594921 ! sister chromatid segregation GO:0000819 46 33 0,000 0,15353481 0,17586159 ! ear morphogenesis GO:0042471 42 33 0,000 0,15353481 0,17577405 ! cell junction organization GO:0034330 63 33 0,000 0,15353481 0,1756866 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,15353481 0,17559924 ! nucleus organization GO:0006997 49 33 0,000 0,15353481 0,17551196 ! female gonad development GO:0008585 49 33 0,000 0,15353481 0,17542477 ! positive regulation of cell development GO:0010720 54 33 0,000 0,15353481 0,17533767 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,15353481 0,17525065 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,15353481 0,17516372 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,15353481 0,17507688 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,15353481 0,17499012 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,15353481 0,17490345 ! mRNA catabolic process GO:0006402 48 34 0,000 0,15780376 0,17967755 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,15780376 0,17958865 ! feeding behavior GO:0007631 45 34 0,000 0,15780376 0,17949983 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,15780376 0,1794111 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,15780376 0,17932246 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,15780376 0,17923391 ! neuron migration GO:0001764 46 34 0,000 0,15780376 0,17914544 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,15780376 0,17905706 ! female gamete generation GO:0007292 43 34 0,000 0,15780376 0,17896877 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,15780376 0,17888056 ! polyol metabolic process GO:0019751 44 34 0,000 0,15780376 0,17879244 ! aerobic respiration GO:0009060 47 34 0,000 0,15780376 0,17870441 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,15780376 0,17861647 ! embryonic organ development GO:0048568 45 34 0,000 0,15780376 0,17852861 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,15780376 0,17844083 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,16205143 0,18315395 ! Notch signaling pathway GO:0007219 56 35 0,000 0,16205143 0,18306399 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,16205143 0,18297412 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,16205143 0,18288434 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,16205143 0,18279465 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,16205143 0,18270504 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,16205143 0,18261553 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,16205143 0,1825261 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,16205143 0,18243675 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,16205143 0,1823475 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,16627791 0,18701184 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,16627791 0,18692043 ! neural tube development GO:0021915 50 36 0,000 0,16627791 0,18682912 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,16627791 0,18673789 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,16627791 0,18664676 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,16627791 0,18655571 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,16627791 0,18646475 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,17048332 0,19108754 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,17048332 0,19099447 ! ion transmembrane transport GO:0034220 56 37 0,000 0,17048332 0,19090148 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,17048332 0,19080858 ! regulation of protein secretion GO:0050708 51 37 0,000 0,17048332 0,19071578 ! amino acid activation GO:0043038 52 37 0,000 0,17048332 0,19062306 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,17048332 0,19053044 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,17466776 0,19511211 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,17466776 0,1950174 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,17466776 0,19492278 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,17466776 0,19482824 ! phagocytosis GO:0006909 60 38 0,000 0,17466776 0,19473381 ! mesenchymal cell development GO:0014031 64 38 0,000 0,17466776 0,19463946 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,17466776 0,1945452 ! maintenance of location in cell GO:0051651 69 38 0,000 0,17466776 0,19445104 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,17883132 0,19898986 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,17883132 0,19889364 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,17883132 0,19879751 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,17883132 0,19870147 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,17883132 0,19860552 ! chromatin remodeling GO:0006338 68 39 0,000 0,17883132 0,19850967 ! JNK cascade GO:0007254 54 39 0,000 0,17883132 0,19841391 ! synapse organization GO:0050808 55 39 0,000 0,17883132 0,19831825 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,18297412 0,20281469 ! regulation of tube size GO:0035150 60 40 0,000 0,18297412 0,20271699 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,18297412 0,20261939 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,18297412 0,20252189 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,18297412 0,20242447 ! peptide metabolic process GO:0006518 56 40 0,000 0,18297412 0,20232715 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,18297412 0,20222993 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,18297412 0,2021328 ! double-strand break repair GO:0006302 67 40 0,000 0,18297412 0,20203576 ! B cell differentiation GO:0030183 62 40 0,000 0,18297412 0,20193881 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,18297412 0,20184196 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,18297412 0,2017452 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,18297412 0,20164853 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,18709626 0,20609262 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,18709626 0,20599396 ! endosome transport GO:0016197 71 41 0,000 0,18709626 0,2058954 ! striated muscle contraction GO:0006941 62 41 0,000 0,18709626 0,20579693 ! biopolymer methylation GO:0043414 62 41 0,000 0,18709626 0,20569856 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,18709626 0,20560028 ! mitochondrial transport GO:0006839 60 42 0,000 0,19119783 0,21000717 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,19119783 0,20990692 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,19119783 0,20980678 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,19119783 0,20970673 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,19119783 0,20960677 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,19119783 0,20950691 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,19119783 0,20940715 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,19119783 0,20930748 ! leukocyte migration GO:0050900 60 43 0,000 0,19527894 0,21367344 ! neuromuscular process GO:0050905 79 43 0,000 0,19527894 0,21357183 ! activation of caspase activity GO:0006919 65 43 0,000 0,19527894 0,21347033 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,19527894 0,21336891 ! tRNA processing GO:0008033 49 43 0,000 0,19527894 0,2132676 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,19527894 0,21316638 ! methylation GO:0032259 64 43 0,000 0,19527894 0,21306526 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,19933969 0,21739274 ! glycolysis GO:0006096 53 44 0,000 0,19933969 0,21728971 ! regulation of action potential GO:0001508 71 44 0,000 0,19933969 0,21718678 ! regulation of ion transport GO:0043269 57 44 0,000 0,19933969 0,21708395 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,19933969 0,21698121 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,19933969 0,21687857 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,19933969 0,21677603 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,19933969 0,21667358 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,19933969 0,21657123 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,19933969 0,21646898 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,19933969 0,21636682 ! RNA catabolic process GO:0006401 64 45 0,000 0,20338019 0,22064831 ! positive regulation of defense response GO:0031349 59 45 0,000 0,20338019 0,22054428 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,20338019 0,22044035 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,20338019 0,22033652 ! cell recognition GO:0008037 58 45 0,000 0,20338019 0,22023278 ! cell maturation GO:0048469 60 45 0,000 0,20338019 0,22012914 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,20740052 0,22437497 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,20740052 0,22426948 ! cell redox homeostasis GO:0045454 63 46 0,000 0,20740052 0,22416409 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,20740052 0,2240588 ! regulation of ossification GO:0030278 71 46 0,000 0,20740052 0,22395361 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,21140079 0,22816603 ! viral infectious cycle GO:0019058 71 47 0,000 0,21140079 0,22805901 ! endocrine system development GO:0035270 83 47 0,000 0,21140079 0,2279521 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,21140079 0,22784528 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,21140079 0,22773856 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,21140079 0,22763194 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,21140079 0,22752542 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! chloride transport GO:0006821 67 48 0,000 0,2153811 0,23170091 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,2153811 0,23159258 GO:0010952|positive regulation of peptidase activity, ! gastrulation GO:0007369 73 48 0,000 0,2153811 0,23148436 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,2153811 0,23137624 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,2153811 0,23126822 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,21934155 0,2354109 ! sensory perception of smell GO:0007608 61 49 0,000 0,21934155 0,2353011 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,21934155 0,23519141 ! RNA elongation GO:0006354 62 49 0,000 0,21934155 0,23508181 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,21934155 0,23497232 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,21934155 0,23486293 ! cartilage development GO:0051216 70 49 0,000 0,21934155 0,23475364 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,22328224 0,23886007 ! proton transport GO:0015992 75 50 0,000 0,22328224 0,23874902 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,22328224 0,23863808 ! positive regulation of secretion GO:0051047 71 51 0,000 0,22720325 0,24271597 ! hydrogen transport GO:0006818 77 51 0,000 0,22720325 0,24260329 ! adult behavior GO:0030534 80 51 0,000 0,22720325 0,24249071 ! transition metal ion transport GO:0000041 74 52 0,000 0,2311047 0,24654026 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,2311047 0,24642596 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,23498667 0,25044919 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,23498667 0,25033318 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,23498667 0,25021729 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,23498667 0,2501015 ! kidney development GO:0001822 90 53 0,000 0,23498667 0,24998582 ! single fertilization GO:0007338 59 53 0,000 0,23498667 0,24987025 ! amino acid transport GO:0006865 84 54 0,000 0,23884927 0,25386013 ! glucose catabolic process GO:0006007 66 54 0,000 0,23884927 0,25374287 ! DNA catabolic process GO:0006308 67 54 0,000 0,23884927 0,25362572 ! detection of external stimulus GO:0009581 66 54 0,000 0,23884927 0,25350868 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,23884927 0,25339175 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,23884927 0,25327493 ! exocytosis GO:0006887 74 55 0,000 0,24269258 0,25723177 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,24269258 0,25711328 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,24269258 0,2569949 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,24651671 0,26092426 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,25032174 0,26482981 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,25032174 0,26470805 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,25032174 0,2645864 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,25032174 0,26446486 ! camera-type eye development GO:0043010 88 57 0,000 0,25032174 0,26434344 ! secondary metabolic process GO:0019748 84 57 0,000 0,25032174 0,26422212 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,25410778 0,26809536 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,25787491 0,27194511 ! actin filament organization GO:0007015 95 59 0,000 0,25787491 0,27182048 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,25787491 0,27169597 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,26162323 0,27551897 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,26162323 0,27539288 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,26162323 0,27526689 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,26162323 0,27514103 ! regulation of heart contraction GO:0008016 91 60 0,000 0,26162323 0,27501528 ! fertilization GO:0009566 68 60 0,000 0,26162323 0,27488964 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,26162323 0,27476412 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,26535284 0,27855387 ! meiosis GO:0007126 96 61 0,000 0,26535284 0,27842679 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,26535284 0,27829983 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,26535284 0,27817298 ! extracellular matrix organization GO:0030198 103 61 0,000 0,26535284 0,27804625 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,26535284 0,27791964 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,26535284 0,27779314 ! amine catabolic process GO:0009310 90 62 0,000 0,26906381 0,28154994 ! neurotransmitter transport GO:0006836 81 62 0,000 0,26906381 0,28142191 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,26906381 0,28129399 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,26906381 0,28116618 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,26906381 0,2810385 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,26906381 0,28091093 ! meiotic cell cycle GO:0051321 97 62 0,000 0,26906381 0,28078347 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,27275626 0,28450766 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,27643026 0,28820925 ! appendage morphogenesis GO:0035107 93 64 0,000 0,27643026 0,28807866 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,27643026 0,28794819 ! hexose catabolic process GO:0019320 82 64 0,000 0,27643026 0,28781784 ! adaptive immune response GO:0002250 94 64 0,000 0,27643026 0,2876876 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of caspase activity GO:0043281 97 65 0,000 0,28008591 0,29136029 ! appendage development GO:0048736 94 65 0,000 0,28008591 0,29122857 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,28008591 0,29109697 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,28008591 0,29096549 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,28008591 0,29083413 ! activation of immune response GO:0002253 83 65 0,000 0,28008591 0,29070289 ! axon guidance GO:0007411 99 66 0,000 0,2837233 0,29434533 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,28734252 0,29796565 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,28734252 0,29783137 ! acute inflammatory response GO:0002526 92 68 0,000 0,29094366 0,30142812 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,29094366 0,3012924 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,29094366 0,30115681 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,29094366 0,30102133 ! rhythmic process GO:0048511 105 68 0,000 0,29094366 0,30088598 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,29452681 0,30445468 ! response to drug GO:0042493 108 69 0,000 0,29452681 0,30431791 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,29452681 0,30418126 ! humoral immune response GO:0006959 86 70 0,000 0,29809206 0,3077252 ! eye development GO:0001654 111 70 0,000 0,29809206 0,30758714 ! amine transport GO:0015837 101 70 0,000 0,29809206 0,30744921 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,29809206 0,3073114 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,30163949 0,31082923 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,30163949 0,31069003 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,30163949 0,31055095 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,30163949 0,31041201 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,30163949 0,31027318 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,3051692 0,31376359 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,30868127 0,31723276 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,31217578 0,3206808 ! digestion GO:0007586 97 74 0,000 0,31217578 0,32053764 ! negative regulation of growth GO:0045926 123 75 0,000 0,31565284 0,3239632 ! regulation of ligase activity GO:0051340 114 75 0,000 0,31565284 0,3238187 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,31565284 0,32367433 ! amine biosynthetic process GO:0009309 97 76 0,000 0,31911251 0,3270761 ! tRNA metabolic process GO:0006399 95 76 0,000 0,31911251 0,32693041 ! response to unfolded protein GO:0006986 99 76 0,000 0,31911251 0,32678485 ! regulation of protein transport GO:0051223 114 76 0,000 0,31911251 0,32663942 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,32255489 0,33001613 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,32255489 0,32986939 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,32255489 0,32972278 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,32598007 0,33307604 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,32938812 0,33640883 ! cellular respiration GO:0045333 107 79 0,000 0,32938812 0,33625951 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,32938812 0,33611033 ! regulation of lyase activity GO:0051339 133 79 0,000 0,32938812 0,33596128 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,32938812 0,33581236 ! alcohol catabolic process GO:0046164 104 80 0,000 0,33277914 0,33911919 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,33277914 0,33896901 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,33277914 0,33881895 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,3361532 0,34210281 ! mRNA transport GO:0051028 121 81 0,000 0,3361532 0,34195151 ! response to protein stimulus GO:0051789 111 81 0,000 0,3361532 0,34180034 ! vitamin metabolic process GO:0006766 103 81 0,000 0,3361532 0,3416493 ! detection of stimulus GO:0051606 108 82 0,000 0,33951039 0,34490897 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,3428508 0,34814871 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,3428508 0,34799507 ! regulation of defense response GO:0031347 117 84 0,000 0,3461745 0,35121366 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,3461745 0,3510588 ! sterol metabolic process GO:0016125 120 84 0,000 0,3461745 0,35090408 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,34948159 0,35410029 ! rRNA metabolic process GO:0016072 107 85 0,000 0,34948159 0,35394436 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,34948159 0,35378858 ! regulation of protein localization GO:0032880 132 85 0,000 0,34948159 0,35363293 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,35277213 0,35680559 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,35604622 0,35995882 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,35604622 0,35980066 ! female pregnancy GO:0007565 130 87 0,000 0,35604622 0,35964265 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,35930394 0,36277395 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,35930394 0,36261477 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,35930394 0,36245573 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,35930394 0,36229682 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,36254536 0,36540505 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,36254536 0,36524499 ! hormone metabolic process GO:0042445 121 90 0,000 0,36577056 0,36833288 ! RNA localization GO:0006403 135 91 0,000 0,36897963 0,37140182 ! ATP metabolic process GO:0046034 137 91 0,000 0,36897963 0,37123935 ! response to virus GO:0009615 122 91 0,000 0,36897963 0,37107703 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,37217265 0,37412461 ! DNA recombination GO:0006310 146 92 0,000 0,37217265 0,37396116 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,3753497 0,37698878 ! electron transport chain GO:0022900 123 94 0,000 0,37851085 0,3799978 ! angiogenesis GO:0001525 149 95 0,000 0,38165618 0,38298831 ! carboxylic acid transport GO:0046942 147 95 0,000 0,38165618 0,38282129 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,38478577 0,38579219 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,38478577 0,38562409 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,38789971 0,38857549 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! extracellular structure organization GO:0043062 156 99 0,000 0,3940809 0,39459559 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,39714832 0,39749397 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,39714832 0,39732107 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,39714832 0,39714832