pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1087-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of glycolysis GO:0045821 13 5 2,000 6,678E-08 1,632E-04 ! nuclear migration GO:0007097 13 6 2,000 1,334E-07 1,629E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 1,334E-07 1,086E-04 GO:0031272|regulation of pseudopodium assembly, ! regulation of protein complex assembly GO:0043254 132 63 4,000 1,423E-07 8,69E-05 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 3,725E-07 1,82E-04 ! gas homeostasis GO:0033483 14 8 2,000 3,725E-07 1,517E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 3,725E-07 1,3E-04 ! positive regulation of glucose metabolic process GO:0010907 18 9 2,000 5,579E-07 1,704E-04 ! regulation of glycolysis GO:0006110 20 9 2,000 5,579E-07 1,514E-04 ! macrophage differentiation GO:0030225 15 9 2,000 5,579E-07 1,363E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 2,000 7,959E-07 1,768E-04 GO:0043470|regulation of carbohydrate catabolic process, ! nucleus localization GO:0051647 22 11 2,000 1,093E-06 2,225E-04 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 1,455E-06 2,735E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 1,455E-06 2,539E-04 ! regulation of gene-specific transcription GO:0032583 102 46 3,000 1,881E-06 3,064E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 2,000 1,889E-06 2,885E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 2,997E-06 4,307E-04 ! regulation of glucose metabolic process GO:0010906 28 16 2,000 3,684E-06 5E-04 ! filopodium assembly GO:0046847 42 17 2,000 4,467E-06 5,744E-04 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 5,353E-06 6,539E-04 ! microspike assembly GO:0030035 46 18 2,000 5,353E-06 6,228E-04 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 7,458E-06 8,282E-04 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of lipid metabolic process GO:0019216 132 66 3,000 8,073E-06 8,575E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 8,689E-06 8,845E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 9,642E-06 9,422E-04 ! inactivation of MAPK activity GO:0000188 45 22 2,000 1,005E-05 9,441E-04 ! negative regulation of kinase activity GO:0033673 145 70 3,000 1,021E-05 9,24E-04 ! negative regulation of transferase activity GO:0051348 155 74 3,000 1,274E-05 1,112E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 1,317E-05 1,109E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 1,494E-05 1,217E-03 ! vasculogenesis GO:0001570 49 25 2,000 1,494E-05 1,178E-03 ! interaction with host GO:0051701 66 25 2,000 1,494E-05 1,141E-03 ! protein tetramerization GO:0051262 57 25 2,000 1,494E-05 1,106E-03 ! protein oligomerization GO:0051259 149 79 3,000 1,652E-05 1,187E-03 ! response to hypoxia GO:0001666 178 81 3,000 1,824E-05 1,273E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 1,895E-05 1,286E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 1,895E-05 1,251E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 1,895E-05 1,219E-03 ! response to oxygen levels GO:0070482 183 83 3,000 2,009E-05 1,258E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 2,62E-05 1,6E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 3,192E-05 1,902E-03 ! positive regulation of gene-specific transcription GO:0043193 70 33 2,000 3,507E-05 2,04E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 3,593E-05 2,041E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 3,593E-05 1,995E-03 ! mRNA transcription GO:0009299 10 5 1,000 3,593E-05 1,951E-03 ! positive regulation of vasoconstriction GO:0045907 10 5 1,000 3,593E-05 1,908E-03 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 1,000 3,593E-05 1,868E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 3,593E-05 1,829E-03 ! regulation of hair follicle development GO:0051797 10 5 1,000 3,593E-05 1,791E-03 GO:0042634|regulation of hair cycle, ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 3,841E-05 1,877E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 3,841E-05 1,84E-03 ! leukocyte differentiation GO:0002521 232 98 3,000 3,864E-05 1,816E-03 ! tissue remodeling GO:0048771 78 37 2,000 4,966E-05 2,289E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 5,383E-05 2,435E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 5,383E-05 2,391E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 5,383E-05 2,348E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 5,383E-05 2,307E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 5,383E-05 2,267E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 5,385E-05 2,23E-03 ! carbohydrate homeostasis GO:0033500 59 39 2,000 5,825E-05 2,372E-03 GO:0042593|glucose homeostasis, ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 6,776E-05 2,714E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 6,776E-05 2,67E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of helicase activity GO:0051095 16 7 1,000 7,527E-05 2,919E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 7,527E-05 2,873E-03 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 1,000 7,527E-05 2,829E-03 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 1,000 7,527E-05 2,786E-03 ! vesicle fusion GO:0006906 20 7 1,000 7,527E-05 2,744E-03 ! male sex determination GO:0030238 15 7 1,000 7,527E-05 2,704E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 7,527E-05 2,665E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 7,527E-05 2,627E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 7,527E-05 2,59E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 7,527E-05 2,554E-03 ! positive regulation of microtubule polymerization GO:0031116 15 7 1,000 7,527E-05 2,519E-03 ! hemoglobin metabolic process GO:0020027 14 8 1,000 1,002E-04 3,309E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,002E-04 3,265E-03 ! ER overload response GO:0006983 13 8 1,000 1,002E-04 3,222E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 1,002E-04 3,18E-03 ! response to tumor cell GO:0002347 16 8 1,000 1,002E-04 3,139E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,002E-04 3,099E-03 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 1,002E-04 3,061E-03 ! positive regulation of epidermis development GO:0045684 13 8 1,000 1,002E-04 3,023E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 1,002E-04 2,986E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 1,000 1,002E-04 2,95E-03 ! regulation of microtubule polymerization GO:0031113 17 8 1,000 1,002E-04 2,915E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 1,022E-04 2,938E-03 ! positive regulation of DNA binding GO:0043388 83 48 2,000 1,089E-04 3,094E-03 ! regulation of epithelial cell differentiation GO:0030856 18 9 1,000 1,287E-04 3,614E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,287E-04 3,573E-03 ! regulation of cell projection organization GO:0031344 135 51 2,000 1,306E-04 3,584E-03 ! positive regulation of binding GO:0051099 88 52 2,000 1,384E-04 3,756E-03 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 1,465E-04 3,933E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 1,607E-04 4,267E-03 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 1,607E-04 4,221E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,607E-04 4,176E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 1,607E-04 4,132E-03 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 1,607E-04 4,089E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 1,607E-04 4,047E-03 ! regulation of protein polymerization GO:0032271 117 55 2,000 1,636E-04 4,079E-03 ! regulation of DNA replication GO:0006275 105 56 2,000 1,726E-04 4,26E-03 ! heart morphogenesis GO:0003007 105 57 2,000 1,82E-04 4,446E-03 ! positive regulation of cell migration GO:0030335 137 58 2,000 1,916E-04 4,635E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,961E-04 4,698E-03 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,961E-04 4,652E-03 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,961E-04 4,608E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,961E-04 4,564E-03 ! regulation of intracellular pH GO:0051453 21 11 1,000 1,961E-04 4,521E-03 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 1,961E-04 4,478E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 1,961E-04 4,437E-03 ! establishment of organelle localization GO:0051656 122 59 2,000 2,016E-04 4,519E-03 ! viral reproductive process GO:0022415 132 62 2,000 2,336E-04 5,188E-03 ! virus-host interaction GO:0019048 30 12 1,000 2,351E-04 5,174E-03 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 1,000 2,351E-04 5,128E-03 ! entry into host cell GO:0030260 34 12 1,000 2,351E-04 5,082E-03 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 2,351E-04 5,038E-03 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 2,351E-04 4,994E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,351E-04 4,951E-03 ! embryonic placenta development GO:0001892 21 12 1,000 2,351E-04 4,909E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 2,566E-04 5,314E-03 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 2,566E-04 5,269E-03 ! positive regulation of cell motion GO:0051272 157 65 2,000 2,687E-04 5,47E-03 ! regulation of chemokine production GO:0032642 18 13 1,000 2,775E-04 5,603E-03 ! organelle fusion GO:0048284 36 13 1,000 2,775E-04 5,557E-03 ! endocrine pancreas development GO:0031018 25 13 1,000 2,775E-04 5,511E-03 ! response to X-ray GO:0010165 28 13 1,000 2,775E-04 5,467E-03 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 2,775E-04 5,423E-03 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,775E-04 5,38E-03 ! gland morphogenesis GO:0022612 31 13 1,000 2,775E-04 5,338E-03 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 2,775E-04 5,296E-03 ! regulation of epidermis development GO:0045682 19 13 1,000 2,775E-04 5,255E-03 ! myeloid cell differentiation GO:0030099 126 67 2,000 2,939E-04 5,523E-03 ! viral reproduction GO:0016032 142 68 2,000 3,07E-04 5,726E-03 ! cell projection assembly GO:0030031 138 68 2,000 3,07E-04 5,682E-03 ! lipid localization GO:0010876 32 14 1,000 3,233E-04 5,939E-03 GO:0019915|lipid storage, ! regulation of cellular pH GO:0030641 27 14 1,000 3,233E-04 5,895E-03 ! response to gamma radiation GO:0010332 30 14 1,000 3,233E-04 5,851E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 3,233E-04 5,808E-03 ! positive regulation of protein polymerization GO:0032273 27 14 1,000 3,233E-04 5,766E-03 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 3,726E-04 6,596E-03 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 3,726E-04 6,549E-03 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3,726E-04 6,502E-03 ! regulation of vasodilation GO:0042312 27 15 1,000 3,726E-04 6,456E-03 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 3,726E-04 6,411E-03 ! muscle maintenance GO:0046716 26 15 1,000 3,726E-04 6,366E-03 ! organelle localization GO:0051640 155 74 2,000 3,939E-04 6,683E-03 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 4,253E-04 7,166E-03 ! regulation of catabolic process GO:0009894 173 77 2,000 4,427E-04 7,407E-03 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 4,814E-04 8,001E-03 ! regulation of peptidase activity GO:0052547 150 82 2,000 5,323E-04 8,786E-03 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 5,409E-04 8,869E-03 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 5,409E-04 8,81E-03 ! heart looping GO:0001947 34 18 1,000 5,409E-04 8,752E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 5,409E-04 8,694E-03 ! neural crest cell migration GO:0001755 41 18 1,000 5,409E-04 8,637E-03 ! negative regulation of growth GO:0045926 168 85 2,000 5,912E-04 9,379E-03 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 5,912E-04 9,318E-03 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 1,000 6,038E-04 9,456E-03 GO:0019692|deoxyribose phosphate metabolic process, ! positive regulation of angiogenesis GO:0045766 50 20 1,000 6,701E-04 0,01042721 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 6,701E-04 0,01036122 ! protein amino acid acetylation GO:0006473 41 20 1,000 6,701E-04 0,01029605 ! pancreas development GO:0031016 40 20 1,000 6,701E-04 0,0102317 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 6,701E-04 0,01016815 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 6,701E-04 0,01010538 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 6,701E-04 0,01004339 ! regulation of DNA binding GO:0051101 167 89 2,000 6,761E-04 0,01007101 ! lipid phosphorylation GO:0046834 43 21 1,000 7,397E-04 0,01095249 ! regulation of vasoconstriction GO:0019229 40 21 1,000 7,397E-04 0,01088651 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 7,397E-04 0,01082132 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 8,127E-04 0,01181799 ! cellular response to starvation GO:0009267 37 22 1,000 8,127E-04 0,01174806 ! D-ribose metabolic process GO:0006014 36 22 1,000 8,127E-04 0,01167896 ! cell aging GO:0007569 48 22 1,000 8,127E-04 0,01161066 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 1,000 8,127E-04 0,01154315 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 8,682E-04 0,01226046 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 8,89E-04 0,01248176 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of DNA replication GO:0045740 44 23 1,000 8,89E-04 0,01241043 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 8,89E-04 0,01233992 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 8,89E-04 0,0122702 ! deoxyribonucleotide metabolic process GO:0009262 37 23 1,000 8,89E-04 0,01220127 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 8,89E-04 0,0121331 ! skeletal muscle tissue development GO:0007519 223 100 2,000 9,483E-04 0,0128706 GO:0060538|skeletal muscle organ development, ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 9,686E-04 0,0130737 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 9,686E-04 0,01300187 ! sex determination GO:0007530 48 24 1,000 9,686E-04 0,01293082 ! membrane depolarization GO:0051899 45 24 1,000 9,686E-04 0,01286054 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 9,686E-04 0,01279102 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 9,686E-04 0,01272226 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 1,052E-03 0,01373761 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 1,052E-03 0,01366454 ! negative regulation of DNA replication GO:0008156 45 25 1,000 1,052E-03 0,01359224 ! initiation of viral infection GO:0019059 60 26 1,000 1,138E-03 0,01462935 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 1,138E-03 0,01455276 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 1,138E-03 0,01447696 ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 1,138E-03 0,01440195 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 1,138E-03 0,01432771 ! neural crest cell development GO:0014032 59 26 1,000 1,138E-03 0,01425424 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 1,000 1,138E-03 0,01418151 GO:0050768|negative regulation of neurogenesis, ! pentose metabolic process GO:0019321 43 26 1,000 1,138E-03 0,01410953 ! regulation of blood coagulation GO:0030193 46 26 1,000 1,138E-03 0,01403827 ! mitochondrial membrane organization GO:0007006 60 27 1,000 1,227E-03 0,01506652 ! response to starvation GO:0042594 47 27 1,000 1,227E-03 0,01499119 ! response to toxin GO:0009636 49 27 1,000 1,227E-03 0,01491661 ! cellular response to oxidative stress GO:0034599 43 27 1,000 1,227E-03 0,01484276 ! cellular response to nutrient levels GO:0031669 45 27 1,000 1,227E-03 0,01476965 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 1,32E-03 0,01580828 ! protein amino acid acylation GO:0043543 59 28 1,000 1,32E-03 0,01573116 ! vesicle docking GO:0048278 55 28 1,000 1,32E-03 0,0156548 ! base-excision repair GO:0006284 41 28 1,000 1,32E-03 0,01557917 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 1,32E-03 0,01550427 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 1,416E-03 0,01655261 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 1,416E-03 0,01647379 ! somitogenesis GO:0001756 52 29 1,000 1,416E-03 0,01639572 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 1,416E-03 0,01631838 ! complement activation, classical pathway GO:0006958 51 30 1,000 1,515E-03 0,01738043 ! negative regulation of protein kinase cascade GO:0010741 72 30 1,000 1,515E-03 0,01729921 ! regulation of coagulation GO:0050818 52 30 1,000 1,515E-03 0,01721875 ! iron ion homeostasis GO:0055072 60 31 1,000 1,618E-03 0,01829844 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 1,618E-03 0,01821411 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 1,618E-03 0,01813056 ! collagen metabolic process GO:0032963 49 32 1,000 1,724E-03 0,01922722 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 1,000 1,724E-03 0,01913982 ! regulation of pH GO:0006885 56 33 1,000 1,833E-03 0,02025745 ! cholesterol homeostasis GO:0042632 60 33 1,000 1,833E-03 0,0201662 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 46 33 1,000 1,833E-03 0,02007577 ! response to ionizing radiation GO:0010212 74 33 1,000 1,833E-03 0,01998615 ! cholesterol transport GO:0030301 62 34 1,000 1,945E-03 0,02111484 ! DNA damage checkpoint GO:0000077 78 35 1,000 2,06E-03 0,02226795 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 2,06E-03 0,02216985 ! membrane docking GO:0022406 69 35 1,000 2,06E-03 0,02207262 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 2,06E-03 0,02197623 ! sterol transport GO:0015918 63 35 1,000 2,06E-03 0,02188068 ! placenta development GO:0001890 53 35 1,000 2,06E-03 0,02178596 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 2,178E-03 0,02293975 ! embryonic organ development GO:0048568 67 36 1,000 2,178E-03 0,0228413 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 1,000 2,178E-03 0,02274369 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 2,3E-03 0,02391151 ! regulation of microtubule-based process GO:0032886 86 37 1,000 2,3E-03 0,02381019 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 2,425E-03 0,0249961 ! neutral lipid metabolic process GO:0006638 54 38 1,000 2,425E-03 0,02489107 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 1,000 2,425E-03 0,02478692 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 2,553E-03 0,02598584 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 1,000 2,684E-03 0,02720646 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 1,000 2,684E-03 0,02709404 ! lipid homeostasis GO:0055088 75 40 1,000 2,684E-03 0,02698254 ! glycerol ether metabolic process GO:0006662 57 40 1,000 2,684E-03 0,02687196 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 2,818E-03 0,02810005 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 2,818E-03 0,02798582 ! organic ether metabolic process GO:0018904 59 42 1,000 2,955E-03 0,02923011 ! T cell differentiation GO:0030217 93 42 1,000 2,955E-03 0,02911224 ! cytokinesis GO:0000910 84 42 1,000 2,955E-03 0,02899533 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 3,096E-03 0,0302508 GO:0090047|positive regulation of transcription regulator activity, ! segmentation GO:0035282 78 43 1,000 3,096E-03 0,03013028 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 3,096E-03 0,03001071 ! double-strand break repair GO:0006302 85 44 1,000 3,239E-03 0,03127697 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 3,386E-03 0,03256272 ! B cell differentiation GO:0030183 124 45 1,000 3,386E-03 0,03243502 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 3,535E-03 0,03373531 ! mitochondrial transport GO:0006839 94 48 1,000 3,843E-03 0,03653346 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 3,843E-03 0,03639186 ! JNK cascade GO:0007254 106 49 1,000 4,002E-03 0,03774746 ! protein homooligomerization GO:0051260 84 49 1,000 4,002E-03 0,03760228 ! immunoglobulin mediated immune response GO:0016064 89 50 1,000 4,163E-03 0,03897097 GO:0019724|B cell mediated immunity, ! endocrine system development GO:0035270 109 50 1,000 4,163E-03 0,03882223 ! activation of caspase activity GO:0006919 95 50 1,000 4,163E-03 0,03867461 ! positive regulation of cytokine production GO:0001819 94 50 1,000 4,163E-03 0,03852812 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 4,328E-03 0,03990024 ! viral infectious cycle GO:0019058 104 51 1,000 4,328E-03 0,03975024 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 4,496E-03 0,04113476 ! histone modification GO:0016570 104 52 1,000 4,496E-03 0,04098128 ! positive regulation of growth GO:0045927 96 53 1,000 4,666E-03 0,04237789 ! vesicle organization GO:0016050 127 53 1,000 4,666E-03 0,04222094 ! cartilage development GO:0051216 99 53 1,000 4,666E-03 0,04206514 ! regulation of angiogenesis GO:0045765 125 54 1,000 4,84E-03 0,04346892 ! regulation of muscle contraction GO:0006937 94 54 1,000 4,84E-03 0,0433097 ! membrane fusion GO:0006944 122 54 1,000 4,84E-03 0,04315163 ! covalent chromatin modification GO:0016569 115 54 1,000 4,84E-03 0,04299472 ! regulation of cell shape GO:0008360 142 54 1,000 4,84E-03 0,04283894 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 5,016E-03 0,04424056 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 5,016E-03 0,04408142 ! response to UV GO:0009411 120 55 1,000 5,016E-03 0,04392343 ! positive regulation of caspase activity GO:0043280 108 57 1,000 5,378E-03 0,04692245 GO:0010952|positive regulation of peptidase activity, ! nucleotide-excision repair GO:0006289 91 57 1,000 5,378E-03 0,04675546 ! regulation of actin filament length GO:0030832 118 58 1,000 5,563E-03 0,04819429 ! aging GO:0007568 112 58 1,000 5,563E-03 0,04802399 ! positive regulation of organelle organization GO:0010638 108 58 1,000 5,563E-03 0,04785489 ! lipid modification GO:0030258 112 60 1,000 5,942E-03 0,0509369 ! regulation of cellular component size GO:0032535 125 61 1,000 6,136E-03 0,05241498 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 6,333E-03 0,05390714 ! regulation of homeostatic process GO:0032844 148 62 1,000 6,333E-03 0,05371996 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 6,94E-03 0,05866804 ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 6,94E-03 0,05846573 ! negative regulation of cell growth GO:0030308 142 67 1,000 7,359E-03 0,06178245 ! activation of MAPK activity GO:0000187 124 67 1,000 7,359E-03 0,06157087 ! adaptive immune response GO:0002250 126 68 1,000 7,573E-03 0,06314257 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of cell size GO:0045792 144 69 1,000 7,789E-03 0,06472673 ! lung development GO:0030324 165 69 1,000 7,789E-03 0,06450732 ! activation of immune response GO:0002253 120 70 1,000 8,009E-03 0,06609907 ! protein maturation by peptide bond cleavage GO:0051605 118 70 1,000 8,009E-03 0,06587651 ! cell cycle checkpoint GO:0000075 145 71 1,000 8,231E-03 0,06747564 ! respiratory tube development GO:0030323 171 72 1,000 8,456E-03 0,06908657 ! B cell activation GO:0042113 179 72 1,000 8,456E-03 0,06885628 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 8,456E-03 0,06862752 ! humoral immune response GO:0006959 115 73 1,000 8,683E-03 0,07024081 ! acute inflammatory response GO:0002526 118 74 1,000 8,913E-03 0,07186547 ! regulation of caspase activity GO:0043281 136 74 1,000 8,913E-03 0,07162907 ! respiratory system development GO:0060541 175 74 1,000 8,913E-03 0,07139422 ! regulation of transcription factor activity GO:0051090 137 75 1,000 9,146E-03 0,07302089 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 9,146E-03 0,07278304 ! leukocyte mediated immunity GO:0002443 136 75 1,000 9,146E-03 0,07254673 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 9,382E-03 0,0741753 ! lymphocyte differentiation GO:0030098 193 76 1,000 9,382E-03 0,07393602 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 9,53E-03 0,07485802 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 9,53E-03 0,07461809 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 9,53E-03 0,07437969 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 9,53E-03 0,07414281 ! positive regulation of helicase activity GO:0051096 12 5 0,000 9,53E-03 0,07390744 ! neuron fate determination GO:0048664 7 5 0,000 9,53E-03 0,07367356 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 9,53E-03 0,07344115 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 9,53E-03 0,0732102 ! polyol transport GO:0015791 12 5 0,000 9,53E-03 0,0729807 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 9,53E-03 0,07275264 ! response to superoxide GO:0000303 10 5 0,000 9,53E-03 0,07252599 ! negative regulation of bone resorption GO:0045779 10 5 0,000 9,53E-03 0,07230076 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 9,53E-03 0,07207692 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 9,53E-03 0,07185446 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 9,53E-03 0,07163336 ! female meiosis GO:0007143 10 5 0,000 9,53E-03 0,07141363 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 9,53E-03 0,07119524 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 9,53E-03 0,07097818 ! hypothalamus development GO:0021854 9 5 0,000 9,53E-03 0,07076244 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 9,53E-03 0,07054801 ! cobalt ion transport GO:0006824 11 5 0,000 9,53E-03 0,07033487 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 9,53E-03 0,07012302 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 9,53E-03 0,06991244 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 9,53E-03 0,06970312 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 9,53E-03 0,06949506 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 9,53E-03 0,06928822 ! embryonic camera-type eye development GO:0031076 12 5 0,000 9,53E-03 0,06908262 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 9,53E-03 0,06887824 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 9,53E-03 0,06867505 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 9,53E-03 0,06847307 ! transposition GO:0032196 9 5 0,000 9,53E-03 0,06827227 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 9,53E-03 0,06807264 ! negative chemotaxis GO:0050919 16 5 0,000 9,53E-03 0,06787418 ! positive regulation of histone modification GO:0031058 6 5 0,000 9,53E-03 0,06767687 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 9,53E-03 0,06748071 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 9,53E-03 0,06728568 ! behavioral response to pain GO:0048266 10 5 0,000 9,53E-03 0,06709177 ! clathrin coat assembly GO:0048268 15 5 0,000 9,53E-03 0,06689898 ! Notch receptor processing GO:0007220 11 5 0,000 9,53E-03 0,06670729 ! regulation of dopamine uptake GO:0051584 9 5 0,000 9,53E-03 0,0665167 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 9,53E-03 0,06632719 ! micturition GO:0060073 9 5 0,000 9,53E-03 0,06613876 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 9,53E-03 0,0659514 ! copulation GO:0007620 9 5 0,000 9,53E-03 0,06576509 ! glial cell fate commitment GO:0021781 14 5 0,000 9,53E-03 0,06557984 ! protein maturation by protein folding GO:0022417 14 5 0,000 9,53E-03 0,06539563 ! bioluminescence GO:0008218 9 5 0,000 9,53E-03 0,06521245 ! spermidine metabolic process GO:0008216 7 5 0,000 9,53E-03 0,06503029 ! regulation of potassium ion transport GO:0043266 10 5 0,000 9,53E-03 0,06484915 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 9,53E-03 0,06466901 ! apoptotic cell clearance GO:0043277 23 5 0,000 9,53E-03 0,06448987 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 9,53E-03 0,06431172 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 9,53E-03 0,06413456 ! lipoprotein particle clearance GO:0034381 10 5 0,000 9,53E-03 0,06395836 ! grooming behavior GO:0007625 6 5 0,000 9,53E-03 0,06378313 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 9,53E-03 0,06360886 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 9,53E-03 0,06343554 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 9,53E-03 0,06326316 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 9,53E-03 0,06309172 ! response to protozoan GO:0001562 13 5 0,000 9,53E-03 0,0629212 ! lymph vessel development GO:0001945 10 5 0,000 9,53E-03 0,0627516 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 9,53E-03 0,06258291 ! endochondral ossification GO:0001958 17 5 0,000 9,53E-03 0,06241513 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 9,53E-03 0,06224824 ! single strand break repair GO:0000012 8 5 0,000 9,53E-03 0,06208225 ! parathyroid gland development GO:0060017 14 5 0,000 9,53E-03 0,06191714 ! anagen GO:0042640 7 5 0,000 9,53E-03 0,0617529 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 9,53E-03 0,06158953 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 9,53E-03 0,06142703 ! cytokine secretion GO:0050663 15 5 0,000 9,53E-03 0,06126538 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 9,53E-03 0,06110458 ! ceramide catabolic process GO:0046514 7 5 0,000 9,53E-03 0,06094462 ! skeletal myofibril assembly GO:0014866 12 5 0,000 9,53E-03 0,06078549 ! smooth muscle tissue development GO:0048745 32 5 0,000 9,53E-03 0,0606272 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 9,53E-03 0,06046972 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 9,53E-03 0,06031307 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 9,53E-03 0,06015722 ! cardiac muscle fiber development GO:0048739 12 5 0,000 9,53E-03 0,06000217 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 9,53E-03 0,05984793 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 9,53E-03 0,05969447 ! neutrophil mediated immunity GO:0002446 7 5 0,000 9,53E-03 0,0595418 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 9,53E-03 0,05938991 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 9,53E-03 0,05923879 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 9,53E-03 0,05908844 ! glycine biosynthetic process GO:0006545 7 5 0,000 9,53E-03 0,05893884 ! microvillus organization GO:0032528 8 5 0,000 9,53E-03 0,05879001 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 9,53E-03 0,05864192 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 9,53E-03 0,05849458 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 9,53E-03 0,05834798 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 9,53E-03 0,05820211 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 9,53E-03 0,05805697 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 9,53E-03 0,05791255 ! polyol catabolic process GO:0046174 9 5 0,000 9,53E-03 0,05776884 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 9,53E-03 0,05762585 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 9,53E-03 0,05748356 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 9,53E-03 0,05734198 ! muscle cell migration GO:0014812 8 5 0,000 9,53E-03 0,05720109 ! mitochondrial fission GO:0000266 8 5 0,000 9,53E-03 0,05706089 ! sister chromatid cohesion GO:0007062 15 5 0,000 9,53E-03 0,05692138 ! response to tumor necrosis factor GO:0034612 10 5 0,000 9,53E-03 0,05678255 ! nerve growth factor processing GO:0032455 9 5 0,000 9,53E-03 0,05664439 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 9,53E-03 0,0565069 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 9,53E-03 0,05637008 ! anaerobic glycolysis GO:0019642 6 5 0,000 9,53E-03 0,05623392 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 9,53E-03 0,05609842 ! monocyte activation GO:0042117 10 5 0,000 9,53E-03 0,05596357 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 9,53E-03 0,05582936 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 9,53E-03 0,0556958 ! response to food GO:0032094 6 5 0,000 9,53E-03 0,05556287 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 9,53E-03 0,05543058 ! positive regulation of transporter activity GO:0032411 8 5 0,000 9,53E-03 0,05529892 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 9,53E-03 0,05516788 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 9,53E-03 0,05503746 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 9,53E-03 0,05490765 ! forebrain neuron development GO:0021884 13 5 0,000 9,53E-03 0,05477846 ! lipoprotein catabolic process GO:0042159 11 5 0,000 9,53E-03 0,05464987 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 9,53E-03 0,05452188 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 9,53E-03 0,05439449 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 9,53E-03 0,0542677 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 9,53E-03 0,0541415 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 9,53E-03 0,05401588 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 9,53E-03 0,05389084 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 9,53E-03 0,05376638 ! lipid glycosylation GO:0030259 7 5 0,000 9,53E-03 0,0536425 ! nucleobase transport GO:0015851 6 5 0,000 9,53E-03 0,05351918 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 9,53E-03 0,05339643 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 9,53E-03 0,05327424 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 9,53E-03 0,05315261 ! basic amino acid transport GO:0015802 12 5 0,000 9,53E-03 0,05303153 ! cellular glucose homeostasis GO:0001678 6 5 0,000 9,53E-03 0,05291101 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 9,53E-03 0,05279103 ! actin nucleation GO:0045010 11 5 0,000 9,53E-03 0,05267159 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 9,53E-03 0,05255269 ! depurination GO:0045007 5 5 0,000 9,53E-03 0,05243433 ! depyrimidination GO:0045008 10 5 0,000 9,53E-03 0,0523165 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 9,53E-03 0,0521992 ! regulation of centrosome cycle GO:0046605 7 5 0,000 9,53E-03 0,05208242 ! G2/M transition checkpoint GO:0031576 8 5 0,000 9,53E-03 0,05196617 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 9,53E-03 0,05185043 ! zinc ion homeostasis GO:0055069 9 5 0,000 9,53E-03 0,05173521 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 9,53E-03 0,0516205 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 9,53E-03 0,05150629 ! forebrain morphogenesis GO:0048853 13 5 0,000 9,53E-03 0,05139259 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 9,53E-03 0,05127939 ! activated T cell proliferation GO:0050798 16 5 0,000 9,53E-03 0,05116669 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 9,53E-03 0,05105448 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 9,53E-03 0,05094276 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 9,53E-03 0,05083154 ! positive regulation of organ growth GO:0046622 6 5 0,000 9,53E-03 0,05072079 ! gamma-delta T cell activation GO:0046629 6 5 0,000 9,53E-03 0,05061053 ! response to arsenic GO:0046685 11 5 0,000 9,53E-03 0,05050075 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 9,53E-03 0,05039144 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 9,53E-03 0,0502826 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 9,53E-03 0,05017423 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 9,53E-03 0,05006633 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 9,53E-03 0,04995889 ! response to mercury ion GO:0046689 8 5 0,000 9,53E-03 0,04985191 ! response to cadmium ion GO:0046686 7 5 0,000 9,53E-03 0,04974539 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 9,53E-03 0,04963933 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 9,53E-03 0,04953371 ! bile acid biosynthetic process GO:0006699 7 5 0,000 9,53E-03 0,04942854 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 9,53E-03 0,04932382 ! ganglioside catabolic process GO:0006689 12 5 0,000 9,53E-03 0,04921954 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 9,53E-03 0,0491157 ! decidualization GO:0046697 11 5 0,000 9,53E-03 0,0490123 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 9,53E-03 0,04890934 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 9,53E-03 0,0488068 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 9,53E-03 0,04870469 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 9,53E-03 0,04860301 ! embryonic cleavage GO:0040016 6 5 0,000 9,53E-03 0,04850176 ! peroxisome fission GO:0016559 5 5 0,000 9,53E-03 0,04840092 ! histone demethylation GO:0016577 13 5 0,000 9,53E-03 0,04830051 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 9,53E-03 0,0482005 ! mitotic recombination GO:0006312 9 5 0,000 9,53E-03 0,04810092 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 9,53E-03 0,04800174 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 9,53E-03 0,04790297 ! metaphase plate congression GO:0051310 7 5 0,000 9,53E-03 0,04780461 ! regulation of sterol transport GO:0032371 7 5 0,000 9,53E-03 0,04770665 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 9,53E-03 0,04760909 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 9,53E-03 0,04751193 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 9,53E-03 0,04741516 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 9,53E-03 0,04731879 ! muscle cell proliferation GO:0033002 12 5 0,000 9,53E-03 0,04722281 ! skeletal muscle regeneration GO:0043403 8 5 0,000 9,53E-03 0,04712721 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 9,53E-03 0,04703201 ! B cell homeostasis GO:0001782 13 5 0,000 9,53E-03 0,04693718 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 9,53E-03 0,04684274 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 9,53E-03 0,04674868 ! metaphase GO:0051323 11 5 0,000 9,53E-03 0,046655 ! melatonin biosynthetic process GO:0030187 7 5 0,000 9,53E-03 0,04656169 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 9,53E-03 0,04646875 ! cellular response to nutrient GO:0031670 8 5 0,000 9,53E-03 0,04637618 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 9,53E-03 0,04628398 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 9,53E-03 0,04619215 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 9,53E-03 0,04610068 ! definitive hemopoiesis GO:0060216 14 5 0,000 9,53E-03 0,04600957 ! response to redox state GO:0051775 6 5 0,000 9,53E-03 0,04591882 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 9,53E-03 0,04582843 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 9,53E-03 0,0457384 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 9,53E-03 0,04564871 ! brown fat cell differentiation GO:0050873 7 5 0,000 9,53E-03 0,04555938 ! regulation of telomerase activity GO:0051972 7 5 0,000 9,53E-03 0,0454704 ! galactolipid metabolic process GO:0019374 7 5 0,000 9,53E-03 0,04538176 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 9,53E-03 0,04529347 ! porphyrin catabolic process GO:0006787 12 5 0,000 9,53E-03 0,04520552 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 9,53E-03 0,04511791 ! striatum development GO:0021756 14 5 0,000 9,53E-03 0,04503065 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 9,53E-03 0,04494371 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 9,53E-03 0,04485712 ! glial cell migration GO:0008347 10 5 0,000 9,53E-03 0,04477085 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 9,53E-03 0,04468492 ! neural plate morphogenesis GO:0001839 7 5 0,000 9,53E-03 0,04459932 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 9,53E-03 0,04451404 ! somatic stem cell maintenance GO:0035019 15 5 0,000 9,53E-03 0,04442909 ! T cell activation during immune response GO:0002286 9 5 0,000 9,53E-03 0,04434446 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 9,53E-03 0,04426016 ! negative regulation of lipase activity GO:0060192 8 5 0,000 9,53E-03 0,04417617 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 9,53E-03 0,04409251 ! neuroprotection GO:0043526 8 5 0,000 9,53E-03 0,04400916 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 9,53E-03 0,04392612 ! regulation of sensory perception GO:0051931 8 5 0,000 9,53E-03 0,0438434 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 9,53E-03 0,04376098 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 9,53E-03 0,04367888 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 9,53E-03 0,04359709 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 9,53E-03 0,0435156 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 9,53E-03 0,04343441 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 9,53E-03 0,04335353 ! sequestering of calcium ion GO:0051208 7 5 0,000 9,53E-03 0,04327294 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 9,53E-03 0,04319266 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 9,53E-03 0,04311267 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 9,53E-03 0,04303298 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 9,53E-03 0,04295359 ! spindle assembly GO:0051225 6 5 0,000 9,53E-03 0,04287448 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 9,53E-03 0,04279567 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 9,53E-03 0,04271714 ! protein palmitoylation GO:0018345 12 5 0,000 9,53E-03 0,04263891 ! drug metabolic process GO:0017144 7 5 0,000 9,53E-03 0,04256096 ! stem cell division GO:0017145 11 5 0,000 9,53E-03 0,04248329 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 9,53E-03 0,04240591 ! organ regeneration GO:0031100 7 5 0,000 9,53E-03 0,04232881 ! carnitine metabolic process GO:0009437 8 5 0,000 9,53E-03 0,04225198 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 9,53E-03 0,04217544 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 9,62E-03 0,04250006 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 9,62E-03 0,04242335 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,01010517 0,04448096 ! protein import into nucleus GO:0006606 174 82 1,000 0,01085236 0,047684 ! response to drug GO:0042493 149 83 1,000 0,0111067 0,04871394 ! nuclear import GO:0051170 177 83 1,000 0,0111067 0,04862664 ! T cell activation GO:0042110 189 84 1,000 0,01136366 0,04966267 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01142477 0,04984056 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01142477 0,04975172 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01142477 0,04966319 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01142477 0,04957498 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01142477 0,04948708 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01142477 0,04939949 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01142477 0,04931221 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01142477 0,04922524 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01142477 0,04913858 ! response to oxygen radical GO:0000305 11 6 0,000 0,01142477 0,04905222 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01142477 0,04896616 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01142477 0,04888041 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01142477 0,04879495 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01142477 0,04870979 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01142477 0,04862493 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01142477 0,04854037 ! forebrain regionalization GO:0021871 9 6 0,000 0,01142477 0,0484561 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01142477 0,04837212 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01142477 0,04828843 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01142477 0,04820503 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01142477 0,04812192 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01142477 0,04803909 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01142477 0,04795655 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01142477 0,04787429 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01142477 0,04779232 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01142477 0,04771062 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01142477 0,0476292 ! malate metabolic process GO:0006108 13 6 0,000 0,01142477 0,04754806 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01142477 0,0474672 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01142477 0,04738661 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01142477 0,04730629 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01142477 0,04722625 ! protein refolding GO:0042026 15 6 0,000 0,01142477 0,04714647 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01142477 0,04706697 ! opsonization GO:0008228 8 6 0,000 0,01142477 0,04698773 ! mating behavior GO:0007617 7 6 0,000 0,01142477 0,04690876 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01142477 0,04683005 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01142477 0,04675161 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01142477 0,04667343 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01142477 0,04659551 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01142477 0,04651785 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01142477 0,04644045 ! toxin metabolic process GO:0009404 11 6 0,000 0,01142477 0,04636331 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01142477 0,04628642 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01142477 0,04620979 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01142477 0,04613341 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01142477 0,04605728 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01142477 0,0459814 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01142477 0,04590578 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01142477 0,0458304 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01142477 0,04575527 ! thymic T cell selection GO:0045061 16 6 0,000 0,01142477 0,04568038 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01142477 0,04560574 ! protein lipoylation GO:0009249 10 6 0,000 0,01142477 0,04553134 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01142477 0,04545719 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01142477 0,04538327 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01142477 0,0453096 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01142477 0,04523616 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01142477 0,04516296 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01142477 0,04509 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01142477 0,04501728 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01142477 0,04494479 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01142477 0,04487253 ! hyperosmotic response GO:0006972 10 6 0,000 0,01142477 0,0448005 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01142477 0,04472871 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01142477 0,04465714 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01142477 0,0445858 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01142477 0,04451469 ! urea metabolic process GO:0019627 7 6 0,000 0,01142477 0,04444381 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01142477 0,04437315 ! neutrophil activation GO:0042119 7 6 0,000 0,01142477 0,04430272 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01142477 0,04423251 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01142477 0,04416252 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01142477 0,04409275 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01142477 0,04402321 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01142477 0,04395388 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01142477 0,04388477 ! neuron apoptosis GO:0051402 15 6 0,000 0,01142477 0,04381587 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01142477 0,0437472 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01142477 0,04367874 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01142477 0,04361049 ! carnitine transport GO:0015879 10 6 0,000 0,01142477 0,04354245 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01142477 0,04347463 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01142477 0,04340702 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01142477 0,04333962 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01142477 0,04327242 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01142477 0,04320544 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01142477 0,04313866 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01142477 0,04307209 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01142477 0,04300572 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01142477 0,04293956 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01142477 0,0428736 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01142477 0,04280784 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01142477 0,04274229 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01142477 0,04267693 ! response to UV-C GO:0010225 14 6 0,000 0,01142477 0,04261177 ! astrocyte development GO:0014002 16 6 0,000 0,01142477 0,04254682 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01142477 0,04248206 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01142477 0,0424175 ! interaction with symbiont GO:0051702 14 6 0,000 0,01142477 0,04235313 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01142477 0,04228896 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01142477 0,04222498 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01142477 0,0421612 ! response to copper ion GO:0046688 10 6 0,000 0,01142477 0,04209761 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01142477 0,04203421 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01142477 0,041971 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01142477 0,04190798 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01142477 0,04184515 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01142477 0,0417825 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01142477 0,04172005 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01142477 0,04165778 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01142477 0,0415957 ! hair follicle maturation GO:0048820 8 6 0,000 0,01142477 0,0415338 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01142477 0,04147208 ! Schwann cell development GO:0014044 15 6 0,000 0,01142477 0,04141055 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01142477 0,0413492 ! response to pheromone GO:0019236 6 6 0,000 0,01142477 0,04128804 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01142477 0,04122705 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01142477 0,04116624 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01142477 0,04110561 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01142477 0,04104517 ! subpallium development GO:0021544 15 6 0,000 0,01142477 0,04098489 ! neural tube patterning GO:0021532 8 6 0,000 0,01142477 0,0409248 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01142477 0,04086488 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01142477 0,04080513 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01142477 0,04074557 ! G2 phase GO:0051319 16 6 0,000 0,01142477 0,04068617 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01142477 0,04062695 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01142477 0,0405679 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01142477 0,04050902 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01142477 0,04045031 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01142477 0,04039177 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01142477 0,0403334 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01142477 0,0402752 ! receptor internalization GO:0031623 11 6 0,000 0,01142477 0,04021716 ! plasminogen activation GO:0031639 9 6 0,000 0,01142477 0,0401593 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01142477 0,0401016 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01142477 0,04004406 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01142477 0,03998669 ! protein deubiquitination GO:0016579 16 6 0,000 0,01142477 0,03992949 ! protein destabilization GO:0031648 9 6 0,000 0,01142477 0,03987245 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01142477 0,03981557 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01142477 0,03975885 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01142477 0,03970229 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01142477 0,0396459 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01142477 0,03958966 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01142477 0,03953359 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01142477 0,03947767 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01142477 0,03942191 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01142477 0,03936631 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01142477 0,03931086 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01142477 0,03925557 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01142477 0,03920044 ! neural plate development GO:0001840 9 6 0,000 0,01142477 0,03914546 ! catecholamine transport GO:0051937 9 6 0,000 0,01142477 0,03909063 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01142477 0,03903596 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01142477 0,03898144 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01142477 0,03892707 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01142477 0,03887286 ! maternal placenta development GO:0001893 12 6 0,000 0,01142477 0,03881879 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01142477 0,03876488 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01142477 0,03871111 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01142477 0,0386575 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01142477 0,03860403 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01142477 0,03855071 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01142477 0,03849753 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01142477 0,03844451 GO:0055081|anion homeostasis, ! mitochondrion organization GO:0007005 159 87 1,000 0,01215019 0,04082931 ! protein localization in nucleus GO:0034504 192 89 1,000 0,01268746 0,04257617 ! gland development GO:0048732 220 91 1,000 0,01323496 0,04435255 ! tRNA transcription GO:0009304 17 7 0,000 0,01331635 0,04456418 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01331635 0,04450322 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01331635 0,04444242 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01331635 0,04438179 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01331635 0,04432132 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01331635 0,04426102 ! sleep GO:0030431 16 7 0,000 0,01331635 0,04420089 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01331635 0,04414091 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01331635 0,0440811 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01331635 0,04402145 ! prostate gland development GO:0030850 14 7 0,000 0,01331635 0,04396196 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01331635 0,04390263 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01331635 0,04384347 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01331635 0,04378446 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01331635 0,04372561 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01331635 0,04366692 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01331635 0,04360838 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01331635 0,04355 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01331635 0,04349178 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01331635 0,04343371 ! glycolipid transport GO:0046836 11 7 0,000 0,01331635 0,0433758 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01331635 0,04331805 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,01331635 0,04326044 ! neuron adhesion GO:0007158 14 7 0,000 0,01331635 0,04320299 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01331635 0,04314569 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01331635 0,04308855 ! mRNA stabilization GO:0048255 18 7 0,000 0,01331635 0,04303155 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01331635 0,04297471 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01331635 0,04291801 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01331635 0,04286147 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01331635 0,04280507 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01331635 0,04274882 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01331635 0,04269272 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01331635 0,04263677 ! lipoprotein transport GO:0042953 14 7 0,000 0,01331635 0,04258096 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01331635 0,0425253 ! rhythmic behavior GO:0007622 17 7 0,000 0,01331635 0,04246978 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01331635 0,04241441 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01331635 0,04235918 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01331635 0,0423041 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01331635 0,04224916 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01331635 0,04219436 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01331635 0,0421397 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01331635 0,04208519 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01331635 0,04203082 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01331635 0,04197658 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01331635 0,04192249 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01331635 0,04186854 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01331635 0,04181472 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01331635 0,04176104 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01331635 0,0417075 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01331635 0,0416541 ! spinal cord patterning GO:0021511 14 7 0,000 0,01331635 0,04160083 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01331635 0,0415477 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01331635 0,04149471 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01331635 0,04144185 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01331635 0,04138912 ! adrenal gland development GO:0030325 17 7 0,000 0,01331635 0,04133653 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01331635 0,04128408 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01331635 0,04123175 ! ovulation GO:0030728 10 7 0,000 0,01331635 0,04117956 ! adenohypophysis development GO:0021984 11 7 0,000 0,01331635 0,0411275 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01331635 0,04107557 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01331635 0,04102377 ! microtubule nucleation GO:0007020 21 7 0,000 0,01331635 0,04097211 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01331635 0,04092057 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01331635 0,04086916 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01331635 0,04081788 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01331635 0,04076673 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01331635 0,04071571 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01331635 0,04066482 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01331635 0,04061405 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01331635 0,04056341 ! galactose metabolic process GO:0006012 13 7 0,000 0,01331635 0,04051289 ! response to dietary excess GO:0002021 8 7 0,000 0,01331635 0,0404625 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01331635 0,04041224 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01331635 0,0403621 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01331635 0,04031208 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01331635 0,04026219 ! organ growth GO:0035265 15 7 0,000 0,01331635 0,04021243 ! nucleoside transport GO:0015858 11 7 0,000 0,01331635 0,04016278 ! nucleoside salvage GO:0043174 11 7 0,000 0,01331635 0,04011326 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01331635 0,04006386 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01331635 0,04001458 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01331635 0,03996542 ! parturition GO:0007567 16 7 0,000 0,01331635 0,03991638 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01331635 0,03986747 ! rRNA modification GO:0000154 14 7 0,000 0,01331635 0,03981867 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01331635 0,03976999 ! spindle checkpoint GO:0031577 16 7 0,000 0,01331635 0,03972143 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01331635 0,03967299 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01331635 0,03962467 ! monocyte differentiation GO:0030224 16 7 0,000 0,01331635 0,03957646 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01331635 0,03952837 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01331635 0,0394804 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01331635 0,03943255 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01331635 0,03938481 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01331635 0,03933719 ! fibrinolysis GO:0042730 11 7 0,000 0,01331635 0,03928968 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01331635 0,03924228 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01331635 0,039195 ! eating behavior GO:0042755 8 7 0,000 0,01331635 0,03914784 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01331635 0,03910078 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01331635 0,03905384 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01331635 0,03900702 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01331635 0,0389603 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01331635 0,0389137 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01331635 0,03886721 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01331635 0,03882083 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01331635 0,03877456 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01331635 0,0387284 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01331635 0,03868235 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01331635 0,0386364 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01331635 0,03859057 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01331635 0,03854485 ! histone ubiquitination GO:0016574 9 7 0,000 0,01331635 0,03849923 ! regulation of meiosis GO:0040020 12 7 0,000 0,01331635 0,03845373 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01331635 0,03840833 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01331635 0,03836303 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01331635 0,03831785 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01331635 0,03827277 ! transcription termination GO:0006353 14 7 0,000 0,01331635 0,03822779 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01331635 0,03818293 ! anaphase GO:0051322 18 7 0,000 0,01331635 0,03813816 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01331635 0,0380935 ! axonal fasciculation GO:0007413 19 7 0,000 0,01331635 0,03804895 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01331635 0,0380045 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01331635 0,03796015 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01331635 0,03791591 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01331635 0,03787177 ! diuresis GO:0030146 12 7 0,000 0,01331635 0,03782774 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01331635 0,0377838 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01331635 0,03773997 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01331635 0,03769624 ! antibiotic transport GO:0042891 9 7 0,000 0,01331635 0,03765261 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01331635 0,03760908 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01331635 0,03756565 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01331635 0,03752232 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01331635 0,03747909 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01331635 0,03743596 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01331635 0,03739293 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01331635 0,03735 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01331635 0,03730717 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01331635 0,03726444 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01331635 0,0372218 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01331635 0,03717926 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01331635 0,03713682 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01331635 0,03709447 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01331635 0,03705222 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01331635 0,03701007 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01331635 0,03696801 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01331635 0,03692605 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01331635 0,03688419 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01331635 0,03684241 ! muscle adaptation GO:0043500 13 7 0,000 0,01331635 0,03680074 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01331635 0,03675916 ! retina homeostasis GO:0001895 12 7 0,000 0,01331635 0,03671767 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01331635 0,03667627 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01331635 0,03663497 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01331635 0,03659376 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,01351252 0,03709112 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,01379262 0,03781747 ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,01379262 0,03777507 ! regulation of membrane potential GO:0042391 179 94 1,000 0,01407523 0,03850591 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,01436034 0,03924197 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,01520437 0,04150199 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,01520437 0,04145567 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,01520437 0,04140945 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,01520437 0,04136334 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,01520437 0,04131733 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,01520437 0,04127142 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,01520437 0,04122562 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,01520437 0,04117991 ! male meiosis GO:0007140 9 8 0,000 0,01520437 0,04113431 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,01520437 0,0410888 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,01520437 0,0410434 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,01520437 0,0409981 ! meiotic prophase I GO:0007128 14 8 0,000 0,01520437 0,0409529 ! response to zinc ion GO:0010043 12 8 0,000 0,01520437 0,0409078 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,01520437 0,04086279 ! oligopeptide transport GO:0006857 16 8 0,000 0,01520437 0,04081789 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,01520437 0,04077308 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,01520437 0,04072838 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,01520437 0,04068377 ! signal peptide processing GO:0006465 12 8 0,000 0,01520437 0,04063926 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,01520437 0,04059484 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,01520437 0,04055052 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,01520437 0,0405063 ! succinate metabolic process GO:0006105 17 8 0,000 0,01520437 0,04046218 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,01520437 0,04041815 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01520437 0,04037422 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,01520437 0,04033038 ! estrogen metabolic process GO:0008210 17 8 0,000 0,01520437 0,04028664 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,01520437 0,04024299 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,01520437 0,04019944 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,01520437 0,04015598 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,01520437 0,04011261 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01520437 0,04006934 ! reflex GO:0060004 17 8 0,000 0,01520437 0,04002616 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,01520437 0,03998308 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,01520437 0,03994009 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,01520437 0,03989719 ! pigment granule organization GO:0048753 17 8 0,000 0,01520437 0,03985438 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,01520437 0,03981166 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,01520437 0,03976904 ! astrocyte differentiation GO:0048708 19 8 0,000 0,01520437 0,0397265 ! histidine catabolic process GO:0006548 10 8 0,000 0,01520437 0,03968406 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,01520437 0,03964171 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,01520437 0,03959945 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,01520437 0,03955727 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,01520437 0,03951519 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,01520437 0,0394732 ! melanin metabolic process GO:0006582 17 8 0,000 0,01520437 0,03943129 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,01520437 0,03938948 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,01520437 0,03934775 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,01520437 0,03930612 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,01520437 0,03926457 ! macrophage activation GO:0042116 13 8 0,000 0,01520437 0,0392231 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,01520437 0,03918173 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,01520437 0,03914044 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,01520437 0,03909924 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,01520437 0,03905813 ! purine salvage GO:0043101 12 8 0,000 0,01520437 0,0390171 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,01520437 0,03897616 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01520437 0,0389353 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,01520437 0,03889453 ! osteoblast development GO:0002076 17 8 0,000 0,01520437 0,03885385 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,01520437 0,03881325 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,01520437 0,03877273 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,01520437 0,0387323 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,01520437 0,03869196 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,01520437 0,0386517 ! response to UV-B GO:0010224 17 8 0,000 0,01520437 0,03861152 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,01520437 0,03857142 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,01520437 0,03853141 ! intermediate filament organization GO:0045109 12 8 0,000 0,01520437 0,03849148 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,01520437 0,03845164 ! cellular extravasation GO:0045123 13 8 0,000 0,01520437 0,03841187 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,01520437 0,03837219 ! response to antibiotic GO:0046677 11 8 0,000 0,01520437 0,03833259 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,01520437 0,03829307 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,01520437 0,03825364 ! DNA topological change GO:0006265 12 8 0,000 0,01520437 0,03821428 ! response to tropane GO:0014073 15 8 0,000 0,01520437 0,038175 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,01520437 0,03813581 ! melanosome transport GO:0032402 13 8 0,000 0,01520437 0,0380967 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,01520437 0,03805766 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,01520437 0,03801871 ! mast cell activation GO:0045576 14 8 0,000 0,01520437 0,03797984 ! multicellular organismal aging GO:0010259 20 8 0,000 0,01520437 0,03794104 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,01520437 0,03790233 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,01520437 0,03786369 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,01520437 0,03782513 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,01520437 0,03778665 ! nucleosome disassembly GO:0006337 14 8 0,000 0,01520437 0,03774825 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,01520437 0,03770993 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,01520437 0,03767168 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,01520437 0,03763352 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,01520437 0,03759542 ! intracellular lipid transport GO:0032365 16 8 0,000 0,01520437 0,03755741 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,01520437 0,03751947 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,01520437 0,03748161 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,01520437 0,03744383 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,01520437 0,03740612 ! hormone catabolic process GO:0042447 17 8 0,000 0,01520437 0,03736849 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,01520437 0,03733093 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,01520437 0,03729345 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,01520437 0,03725605 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,01520437 0,03721872 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,01520437 0,03718146 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,01520437 0,03714428 ! adult feeding behavior GO:0008343 10 8 0,000 0,01520437 0,03710717 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,01520437 0,03707014 ! ATP catabolic process GO:0006200 11 8 0,000 0,01520437 0,03703318 ! blastocyst growth GO:0001832 19 8 0,000 0,01520437 0,03699629 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,01520437 0,03695948 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,01520437 0,03692274 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,01520437 0,03688608 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,01520437 0,03684948 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,01520437 0,03681296 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,01520437 0,03677651 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,01520437 0,03674014 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,01520437 0,03670383 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,01520437 0,0366676 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,01520437 0,03663144 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,01520437 0,03659535 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,01520437 0,03655933 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,01520437 0,03652338 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,01520437 0,0364875 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,01520437 0,0364517 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,01520437 0,03641596 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,01520437 0,03638029 ! positive regulation of immune response GO:0050778 175 100 1,000 0,01582317 0,03782388 ! axon extension GO:0048675 16 9 0,000 0,01708883 0,04080939 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,01708883 0,04076954 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,01708883 0,04072977 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,01708883 0,04069007 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,01708883 0,04065045 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,01708883 0,04061091 ! reproductive behavior GO:0019098 22 9 0,000 0,01708883 0,04057144 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,01708883 0,04053205 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,01708883 0,04049274 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,01708883 0,0404535 ! UTP metabolic process GO:0046051 10 9 0,000 0,01708883 0,04041434 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,01708883 0,04037525 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,01708883 0,04033624 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,01708883 0,04029731 ! artery development GO:0060840 25 9 0,000 0,01708883 0,04025845 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,01708883 0,04021966 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,01708883 0,04018095 ! equilibrioception GO:0050957 20 9 0,000 0,01708883 0,04014232 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,01708883 0,04010376 ! chemosensory behavior GO:0007635 21 9 0,000 0,01708883 0,04006527 ! microtubule bundle formation GO:0001578 22 9 0,000 0,01708883 0,04002686 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,01708883 0,03998852 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,01708883 0,03995025 ! leukocyte degranulation GO:0043299 16 9 0,000 0,01708883 0,03991206 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,01708883 0,03987394 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,01708883 0,03983589 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,01708883 0,03979791 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,01708883 0,03976001 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,01708883 0,03972218 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,01708883 0,03968442 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,01708883 0,03964673 ! protein targeting to ER GO:0045047 25 9 0,000 0,01708883 0,03960912 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,01708883 0,03957157 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,01708883 0,0395341 ! T cell selection GO:0045058 27 9 0,000 0,01708883 0,0394967 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,01708883 0,03945937 ! glycine catabolic process GO:0006546 15 9 0,000 0,01708883 0,03942211 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,01708883 0,03938492 ! endosome organization GO:0007032 20 9 0,000 0,01708883 0,0393478 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,01708883 0,03931074 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,01708883 0,03927376 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,01708883 0,03923685 ! mannose metabolic process GO:0006013 13 9 0,000 0,01708883 0,03920001 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,01708883 0,03916324 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,01708883 0,03912653 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,01708883 0,0390899 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,01708883 0,03905333 ! receptor clustering GO:0043113 20 9 0,000 0,01708883 0,03901683 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,01708883 0,0389804 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,01708883 0,03894404 ! retinol metabolic process GO:0042572 20 9 0,000 0,01708883 0,03890775 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,01708883 0,03887152 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,01708883 0,03883536 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,01708883 0,03879927 ! oligodendrocyte development GO:0014003 11 9 0,000 0,01708883 0,03876324 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,01708883 0,03872728 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,01708883 0,03869139 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,01708883 0,03865557 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,01708883 0,03861981 ! response to amine stimulus GO:0014075 13 9 0,000 0,01708883 0,03858411 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,01708883 0,03854849 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,01708883 0,03851293 ! erythrocyte development GO:0048821 17 9 0,000 0,01708883 0,03847743 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,01708883 0,038442 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,01708883 0,03840663 ! renal water homeostasis GO:0003091 15 9 0,000 0,01708883 0,03837133 ! postreplication repair GO:0006301 25 9 0,000 0,01708883 0,0383361 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,01708883 0,03830093 ! icosanoid secretion GO:0032309 15 9 0,000 0,01708883 0,03826582 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,01708883 0,03823078 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,01708883 0,0381958 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,01708883 0,03816089 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,01708883 0,03812604 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,01708883 0,03809125 ! sterol catabolic process GO:0016127 14 9 0,000 0,01708883 0,03805653 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,01708883 0,03802187 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,01708883 0,03798727 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,01708883 0,03795274 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,01708883 0,03791827 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,01708883 0,03788386 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,01708883 0,03784951 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,01708883 0,03781523 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,01708883 0,03778101 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,01708883 0,03774685 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,01708883 0,03771275 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,01708883 0,03767871 ! purine base metabolic process GO:0006144 25 9 0,000 0,01708883 0,03764473 ! pigment granule transport GO:0051904 17 9 0,000 0,01708883 0,03761082 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,01708883 0,03757697 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,01708883 0,03754318 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,01708883 0,03750944 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,01708883 0,03747577 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,01708883 0,03744216 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,01708883 0,03740861 ! mitochondrion localization GO:0051646 18 9 0,000 0,01708883 0,03737512 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,01896973 0,04145175 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,01896973 0,04141471 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,01896973 0,04137773 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,01896973 0,04134082 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,01896973 0,04130398 ! associative learning GO:0008306 21 10 0,000 0,01896973 0,0412672 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,01896973 0,04123048 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,01896973 0,04119383 ! phosphate transport GO:0006817 24 10 0,000 0,01896973 0,04115725 ! cell volume homeostasis GO:0006884 17 10 0,000 0,01896973 0,04112073 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,01896973 0,04108427 ! CTP metabolic process GO:0046036 11 10 0,000 0,01896973 0,04104788 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,01896973 0,04101156 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,01896973 0,0409753 ! GTP metabolic process GO:0046039 11 10 0,000 0,01896973 0,0409391 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,01896973 0,04090297 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,01896973 0,0408669 ! social behavior GO:0035176 29 10 0,000 0,01896973 0,04083089 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,01896973 0,04079495 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,01896973 0,04075907 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,01896973 0,04072325 ! androgen metabolic process GO:0008209 17 10 0,000 0,01896973 0,0406875 ! phospholipid efflux GO:0033700 19 10 0,000 0,01896973 0,04065181 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,01896973 0,04061618 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,01896973 0,04058061 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,01896973 0,04054511 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,01896973 0,04050967 ! lung alveolus development GO:0048286 26 10 0,000 0,01896973 0,04047429 ! pathogenesis GO:0009405 17 10 0,000 0,01896973 0,04043897 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01896973 0,04040372 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,01896973 0,04036852 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,01896973 0,04033339 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,01896973 0,04029831 ! endoderm development GO:0007492 18 10 0,000 0,01896973 0,0402633 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,01896973 0,04022835 ! arginine catabolic process GO:0006527 17 10 0,000 0,01896973 0,04019346 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,01896973 0,04015863 ! proline metabolic process GO:0006560 13 10 0,000 0,01896973 0,04012386 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,01896973 0,04008915 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,01896973 0,0400545 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,01896973 0,04001992 ! V(D)J recombination GO:0033151 34 10 0,000 0,01896973 0,03998539 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,01896973 0,03995092 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,01896973 0,0399165 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,01896973 0,03988215 ! B cell proliferation GO:0042100 19 10 0,000 0,01896973 0,03984786 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,01896973 0,03981363 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,01896973 0,03977945 ! multicellular organism growth GO:0035264 19 10 0,000 0,01896973 0,03974534 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,01896973 0,03971128 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,01896973 0,03967728 ! ruffle organization GO:0031529 17 10 0,000 0,01896973 0,03964334 ! epithelial cell development GO:0002064 21 10 0,000 0,01896973 0,03960945 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,01896973 0,03957563 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,01896973 0,03954186 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,01896973 0,03950815 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,01896973 0,0394745 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,01896973 0,0394409 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 22 10 0,000 0,01896973 0,03940737 ! copper ion homeostasis GO:0055070 13 10 0,000 0,01896973 0,03937388 ! regulation of bone resorption GO:0045124 25 10 0,000 0,01896973 0,03934046 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,01896973 0,03930709 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,01896973 0,03927378 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,01896973 0,03924053 ! segment specification GO:0007379 15 10 0,000 0,01896973 0,03920733 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,01896973 0,03917419 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,01896973 0,0391411 ! blastoderm segmentation GO:0007350 19 10 0,000 0,01896973 0,03910807 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,01896973 0,03907509 ! response to dsRNA GO:0043331 23 10 0,000 0,01896973 0,03904217 ! DNA ligation GO:0006266 18 10 0,000 0,01896973 0,03900931 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,01896973 0,0389765 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,01896973 0,03894375 ! melanosome localization GO:0032400 16 10 0,000 0,01896973 0,03891105 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,01896973 0,03887841 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,01896973 0,03884582 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,01896973 0,03881328 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,01896973 0,0387808 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,01896973 0,03874838 ! induction of an organ GO:0001759 17 10 0,000 0,01896973 0,03871601 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,01896973 0,03868369 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,01896973 0,03865143 ! protein sumoylation GO:0016925 17 10 0,000 0,01896973 0,03861922 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,01896973 0,03858706 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,01896973 0,03855496 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,01896973 0,03852291 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,01896973 0,03849092 ! salivary gland development GO:0007431 28 10 0,000 0,01896973 0,03845897 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,01896973 0,03842708 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,01896973 0,03839525 ! midbrain development GO:0030901 14 10 0,000 0,01896973 0,03836346 ! musculoskeletal movement GO:0050881 16 10 0,000 0,01896973 0,03833173 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,01896973 0,03830005 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,01896973 0,03826842 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,01896973 0,03823685 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,01896973 0,03820533 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,01896973 0,03817386 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,01896973 0,03814244 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,01896973 0,03811107 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,01896973 0,03807975 ! detection of calcium ion GO:0005513 24 10 0,000 0,01896973 0,03804849 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,01896973 0,03801728 ! blastocyst formation GO:0001825 18 10 0,000 0,01896973 0,03798612 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,01896973 0,03795501 ! cerebellar cortex development GO:0021695 16 10 0,000 0,01896973 0,03792395 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,01896973 0,03789294 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,01896973 0,03786198 ! response to nicotine GO:0035094 20 10 0,000 0,01896973 0,03783107 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,01896973 0,03780021 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,02084709 0,04150729 ! respiratory burst GO:0045730 17 11 0,000 0,02084709 0,04147349 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,02084709 0,04143975 ! neuron fate specification GO:0048665 18 11 0,000 0,02084709 0,04140606 ! telencephalon cell migration GO:0022029 23 11 0,000 0,02084709 0,04137242 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,02084709 0,04133884 ! thyroid gland development GO:0030878 26 11 0,000 0,02084709 0,04130531 ! synapsis GO:0007129 14 11 0,000 0,02084709 0,04127184 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,02084709 0,04123842 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,02084709 0,04120506 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,02084709 0,04117175 ! response to pain GO:0048265 27 11 0,000 0,02084709 0,04113849 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,02084709 0,04110529 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,02084709 0,04107214 ! blood vessel remodeling GO:0001974 30 11 0,000 0,02084709 0,04103904 ! bone resorption GO:0045453 16 11 0,000 0,02084709 0,041006 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,02084709 0,04097301 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,02084709 0,04094007 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,02084709 0,04090719 ! melanocyte differentiation GO:0030318 20 11 0,000 0,02084709 0,04087436 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,02084709 0,04084158 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,02084709 0,04080885 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,02084709 0,04077618 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,02084709 0,04074356 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,02084709 0,04071099 ! UV protection GO:0009650 20 11 0,000 0,02084709 0,04067847 ! adult heart development GO:0007512 16 11 0,000 0,02084709 0,04064601 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,02084709 0,0406136 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,02084709 0,04058123 ! macroautophagy GO:0016236 19 11 0,000 0,02084709 0,04054892 ! temperature homeostasis GO:0001659 18 11 0,000 0,02084709 0,04051667 ! behavioral fear response GO:0001662 27 11 0,000 0,02084709 0,04048446 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,02084709 0,0404523 ! negative regulation of ossification GO:0030279 27 11 0,000 0,02084709 0,0404202 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,02084709 0,04038814 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,02084709 0,04035614 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,02084709 0,04032419 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,02084709 0,04029229 ! regulation of organ growth GO:0046620 14 11 0,000 0,02084709 0,04026043 ! pigment granule localization GO:0051875 20 11 0,000 0,02084709 0,04022863 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,02084709 0,04019688 ! vasoconstriction GO:0042310 20 11 0,000 0,02084709 0,04016518 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,02084709 0,04013353 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,02084709 0,04010193 ! embryonic axis specification GO:0000578 19 11 0,000 0,02084709 0,04007038 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,02084709 0,04003887 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,02084709 0,04000742 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,02084709 0,03997602 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,02084709 0,03994467 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,02084709 0,03991336 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,02084709 0,03988211 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,02084709 0,0398509 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,02084709 0,03981974 ! prophase GO:0051324 17 11 0,000 0,02084709 0,03978863 ! neuroblast proliferation GO:0007405 25 11 0,000 0,02084709 0,03975757 ! nucleosome positioning GO:0016584 15 11 0,000 0,02084709 0,03972656 ! regulation of isotype switching GO:0045191 24 11 0,000 0,02084709 0,0396956 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,02084709 0,03966468 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,02084709 0,03963381 ! apical protein localization GO:0045176 18 11 0,000 0,02084709 0,03960299 ! acid secretion GO:0046717 20 11 0,000 0,02084709 0,03957222 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,02084709 0,0395415 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,02084709 0,03951082 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,02084709 0,03948019 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,02084709 0,03944961 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,02084709 0,03941908 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,02084709 0,03938859 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,02084709 0,03935815 ! cholesterol efflux GO:0033344 21 11 0,000 0,02084709 0,03932776 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,02084709 0,03929741 ! oocyte development GO:0048599 20 11 0,000 0,02084709 0,03926712 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,02084709 0,03923686 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,02084709 0,03920666 ! embryonic gut development GO:0048566 19 11 0,000 0,02084709 0,0391765 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,02084709 0,03914639 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,02084709 0,03911632 ! activation of innate immune response GO:0002218 16 11 0,000 0,02084709 0,0390863 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,02084709 0,03905633 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,02084709 0,0390264 ! lysogeny GO:0030069 22 11 0,000 0,02084709 0,03899652 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,02084709 0,03896668 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,02084709 0,03893689 ! sequestering of metal ion GO:0051238 15 11 0,000 0,02084709 0,03890714 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,02272091 0,0423719 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,02272091 0,04233958 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,02272091 0,04230731 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,02272091 0,04227509 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,02272091 0,04224291 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,02272091 0,04221079 ! protein complex disassembly GO:0043241 28 12 0,000 0,02272091 0,04217871 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,02272091 0,04214669 ! hippocampus development GO:0021766 29 12 0,000 0,02272091 0,04211471 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,02272091 0,04208278 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,02272091 0,0420509 ! T cell proliferation GO:0042098 32 12 0,000 0,02272091 0,04201907 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,02272091 0,04198728 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,02272091 0,04195555 ! ventral spinal cord development GO:0021517 25 12 0,000 0,02272091 0,04192386 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,02272091 0,04189222 ! drug transport GO:0015893 16 12 0,000 0,02272091 0,04186062 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,02272091 0,04182908 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,02272091 0,04179758 ! polyamine metabolic process GO:0006595 18 12 0,000 0,02272091 0,04176613 ! focal adhesion formation GO:0048041 37 12 0,000 0,02272091 0,04173473 ! mitotic spindle organization GO:0007052 23 12 0,000 0,02272091 0,04170337 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,02272091 0,04167206 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,02272091 0,0416408 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,02272091 0,04160959 ! lipid digestion GO:0044241 21 12 0,000 0,02272091 0,04157842 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,02272091 0,0415473 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02272091 0,04151622 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,02272091 0,04148519 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,02272091 0,04145421 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,02272091 0,04142327 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,02272091 0,04139238 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,02272091 0,04136154 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,02272091 0,04133074 ! snRNA metabolic process GO:0016073 30 12 0,000 0,02272091 0,04129999 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,02272091 0,04126928 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,02272091 0,04123862 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,02272091 0,04120801 ! cranial nerve development GO:0021545 23 12 0,000 0,02272091 0,04117744 ! fucose catabolic process GO:0019317 25 12 0,000 0,02272091 0,04114691 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,02272091 0,04111644 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,02272091 0,041086 ! autonomic nervous system development GO:0048483 24 12 0,000 0,02272091 0,04105561 ! zymogen activation GO:0031638 18 12 0,000 0,02272091 0,04102527 ! T cell homeostasis GO:0043029 28 12 0,000 0,02272091 0,04099497 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,02272091 0,04096471 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,02272091 0,0409345 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,02272091 0,04090434 ! oocyte differentiation GO:0009994 21 12 0,000 0,02272091 0,04087422 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,02272091 0,04084414 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,02272091 0,04081411 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,02272091 0,04078412 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,02272091 0,04075418 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,02272091 0,04072428 ! defense response to fungus GO:0050832 15 12 0,000 0,02272091 0,04069442 ! developmental induction GO:0031128 22 12 0,000 0,02272091 0,04066461 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,02272091 0,04063484 ! response to cold GO:0009409 17 12 0,000 0,02272091 0,04060511 ! establishment of cell polarity GO:0030010 21 12 0,000 0,02272091 0,04057543 ! regulation of synapse organization GO:0050807 18 12 0,000 0,02272091 0,04054579 ! localization within membrane GO:0051668 26 12 0,000 0,02272091 0,0405162 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,0245912 0,04381933 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0245912 0,04378739 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,0245912 0,04375549 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0245912 0,04372365 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,0245912 0,04369185 ! peroxisomal transport GO:0043574 28 13 0,000 0,0245912 0,0436601 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,0245912 0,04362839 ! cartilage condensation GO:0001502 22 13 0,000 0,0245912 0,04359673 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,0245912 0,04356512 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,0245912 0,04353355 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,0245912 0,04350202 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,0245912 0,04347055 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,0245912 0,04343911 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,0245912 0,04340773 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,0245912 0,04337639 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,0245912 0,04334509 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,0245912 0,04331384 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,0245912 0,04328263 ! methionine metabolic process GO:0006555 31 13 0,000 0,0245912 0,04325147 ! plasma membrane organization GO:0007009 27 13 0,000 0,0245912 0,04322036 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,0245912 0,04318928 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,0245912 0,04315826 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,0245912 0,04312728 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,0245912 0,04309634 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,0245912 0,04306544 ! exocrine system development GO:0035272 34 13 0,000 0,0245912 0,04303459 ! asymmetric protein localization GO:0008105 24 13 0,000 0,0245912 0,04300379 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,0245912 0,04297303 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,0245912 0,04294231 ! L-glutamate transport GO:0015813 30 13 0,000 0,0245912 0,04291164 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,0245912 0,04288101 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,0245912 0,04285042 ! protein homotetramerization GO:0051289 24 13 0,000 0,0245912 0,04281988 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,0245912 0,04278938 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,0245912 0,04275893 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,0245912 0,04272852 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,0245912 0,04269815 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,0245912 0,04266782 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0245912 0,04263754 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,0245912 0,0426073 ! histone methylation GO:0016571 29 13 0,000 0,0245912 0,0425771 ! chromatin silencing GO:0006342 29 13 0,000 0,0245912 0,04254695 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,0245912 0,04251684 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,0245912 0,04248677 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,0245912 0,04245675 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,0245912 0,04242676 ! spleen development GO:0048536 24 13 0,000 0,0245912 0,04239682 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,0245912 0,04236692 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,0245912 0,04233706 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,0245912 0,04230725 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,0245912 0,04227748 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,0245912 0,04224775 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,0245912 0,04221806 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,0245912 0,04218841 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,0245912 0,0421588 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,0245912 0,04212924 ! insulin secretion GO:0030073 24 13 0,000 0,0245912 0,04209972 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,0245912 0,04207023 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,0245912 0,04204079 ! acrosome reaction GO:0007340 19 13 0,000 0,0245912 0,04201139 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,0245912 0,04198204 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,0245912 0,04195272 ! rRNA transcription GO:0009303 28 14 0,000 0,02645796 0,04510592 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,02645796 0,04507447 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,02645796 0,04504306 ! water transport GO:0006833 21 14 0,000 0,02645796 0,04501169 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,02645796 0,04498037 ! non-recombinational repair GO:0000726 29 14 0,000 0,02645796 0,04494909 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,02645796 0,04491785 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,02645796 0,04488666 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,02645796 0,04485551 ! RNA polyadenylation GO:0043631 32 14 0,000 0,02645796 0,0448244 ! palate development GO:0060021 32 14 0,000 0,02645796 0,04479334 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,02645796 0,04476232 ! regulated secretory pathway GO:0045055 24 14 0,000 0,02645796 0,04473134 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,02645796 0,04470041 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,02645796 0,04466951 ! arginine metabolic process GO:0006525 21 14 0,000 0,02645796 0,04463866 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,02645796 0,04460786 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,02645796 0,04457709 ! regulation of heart rate GO:0002027 25 14 0,000 0,02645796 0,04454637 ! fear response GO:0042596 34 14 0,000 0,02645796 0,04451569 ! organic alcohol transport GO:0015850 29 14 0,000 0,02645796 0,04448506 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,02645796 0,04445446 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,02645796 0,04442391 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,02645796 0,0443934 ! neutral amino acid transport GO:0015804 28 14 0,000 0,02645796 0,04436293 ! bone mineralization GO:0030282 18 14 0,000 0,02645796 0,0443325 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,02645796 0,04430211 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,02645796 0,04427177 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,02645796 0,04424147 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,02645796 0,04421121 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,02645796 0,04418099 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,02645796 0,04415081 ! ribosome assembly GO:0042255 18 14 0,000 0,02645796 0,04412067 ! cerebellum development GO:0021549 23 14 0,000 0,02645796 0,04409058 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,02645796 0,04406052 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,02645796 0,04403051 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,02645796 0,04400053 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,02645796 0,0439706 ! NADP metabolic process GO:0006739 24 14 0,000 0,02645796 0,04394071 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,02645796 0,04391086 ! oxygen transport GO:0015671 22 14 0,000 0,02645796 0,04388105 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,02645796 0,04385128 ! male genitalia development GO:0030539 26 14 0,000 0,02645796 0,04382155 ! regulation of RNA stability GO:0043487 33 14 0,000 0,02645796 0,04379186 ! regulation of axon extension GO:0030516 43 14 0,000 0,02645796 0,04376221 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,02645796 0,0437326 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,02832119 0,04678071 ! lactation GO:0007595 30 15 0,000 0,02832119 0,04674911 ! reproductive cellular process GO:0048610 22 15 0,000 0,02832119 0,04671754 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,02832119 0,04668602 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,02832119 0,04665454 ! superoxide anion generation GO:0042554 22 15 0,000 0,02832119 0,0466231 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,02832119 0,0465917 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,02832119 0,04656035 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,02832119 0,04652904 ! copper ion transport GO:0006825 22 15 0,000 0,02832119 0,04649777 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,02832119 0,04646654 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,02832119 0,04643535 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,02832119 0,04640421 ! sulfate transport GO:0008272 27 15 0,000 0,02832119 0,04637311 ! response to cAMP GO:0051591 25 15 0,000 0,02832119 0,04634205 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,02832119 0,04631103 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,02832119 0,04628005 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,02832119 0,04624912 ! response to hexose stimulus GO:0009746 25 15 0,000 0,02832119 0,04621822 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,02832119 0,04618737 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,02832119 0,04615656 ! vesicle coating GO:0006901 38 15 0,000 0,02832119 0,04612578 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,02832119 0,04609505 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,02832119 0,04606437 ! regulation of exocytosis GO:0017157 26 15 0,000 0,02832119 0,04603372 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,02832119 0,04600311 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,02832119 0,04597254 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,02832119 0,04594202 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,02832119 0,04591153 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,02832119 0,04588109 ! histone deacetylation GO:0016575 24 15 0,000 0,02832119 0,04585068 ! water homeostasis GO:0030104 28 15 0,000 0,02832119 0,04582032 ! cofactor transport GO:0051181 30 15 0,000 0,02832119 0,04578999 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,02832119 0,04575971 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,02832119 0,04572946 ! intestinal absorption GO:0050892 31 15 0,000 0,02832119 0,04569926 ! dopamine metabolic process GO:0042417 35 15 0,000 0,02832119 0,04566909 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,02832119 0,04563897 ! heme biosynthetic process GO:0006783 33 15 0,000 0,02832119 0,04560888 ! cell killing GO:0001906 32 15 0,000 0,02832119 0,04557884 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,02832119 0,04554883 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,02832119 0,04551887 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,02832119 0,04548894 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,02832119 0,04545905 ! actin filament polymerization GO:0030041 27 15 0,000 0,02832119 0,0454292 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,02832119 0,04539939 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,03018092 0,04834884 ! positive regulation of cell size GO:0045793 29 16 0,000 0,03018092 0,04831716 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,03018092 0,04828552 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,03018092 0,04825392 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,03018092 0,04822236 ! bone remodeling GO:0046849 28 16 0,000 0,03018092 0,04819084 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,03018092 0,04815936 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,03018092 0,04812793 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03018092 0,04809653 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,03018092 0,04806518 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,03018092 0,04803387 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,03018092 0,04800259 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,03018092 0,04797136 ! startle response GO:0001964 28 16 0,000 0,03018092 0,04794017 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,03018092 0,04790902 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,03018092 0,04787791 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,03018092 0,04784684 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,03018092 0,04781581 ! protein polyubiquitination GO:0000209 41 16 0,000 0,03018092 0,04778482 ! glutamate metabolic process GO:0006536 25 16 0,000 0,03018092 0,04775388 ! pituitary gland development GO:0021983 30 16 0,000 0,03018092 0,04772297 ! response to osmotic stress GO:0006970 27 16 0,000 0,03018092 0,0476921 ! lysosomal transport GO:0007041 31 16 0,000 0,03018092 0,04766127 ! fructose metabolic process GO:0006000 25 16 0,000 0,03018092 0,04763048 ! L-amino acid transport GO:0015807 33 16 0,000 0,03018092 0,04759973 ! stem cell development GO:0048864 46 16 0,000 0,03018092 0,04756902 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,03018092 0,04753835 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,03018092 0,04750772 ! intermediate filament-based process GO:0045103 36 16 0,000 0,03018092 0,04747713 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,03018092 0,04744658 ! negative regulation of immune response GO:0050777 38 16 0,000 0,03018092 0,04741607 ! axon cargo transport GO:0008088 46 16 0,000 0,03018092 0,04738559 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,03018092 0,04735516 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,03018092 0,04732477 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,03018092 0,04729441 ! DNA replication initiation GO:0006270 28 16 0,000 0,03018092 0,04726409 ! neuron recognition GO:0008038 40 16 0,000 0,03018092 0,04723381 ! mRNA splice site selection GO:0006376 44 16 0,000 0,03018092 0,04720358 ! tissue regeneration GO:0042246 27 16 0,000 0,03018092 0,04717337 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,03018092 0,04714321 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,03018092 0,04711309 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,03018092 0,047083 ! biomineral formation GO:0031214 22 16 0,000 0,03018092 0,04705296 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,03018092 0,04702295 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,03018092 0,04699298 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,03018092 0,04696305 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,03018092 0,04693315 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,03018092 0,0469033 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,03018092 0,04687348 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,03018092 0,0468437 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,03018092 0,04681396 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 27 16 0,000 0,03018092 0,04678425 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,03203714 0,04963014 ! metencephalon development GO:0022037 32 17 0,000 0,03203714 0,04959868 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,03203714 0,04956727 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,03203714 0,0495359 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,03203714 0,04950457 ! signal complex assembly GO:0007172 47 17 0,000 0,03203714 0,04947328 ! endothelial cell migration GO:0043542 31 17 0,000 0,03203714 0,04944202 ! gene silencing by RNA GO:0031047 38 17 0,000 0,03203714 0,04941081 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,03203714 0,04937964 ! glial cell development GO:0021782 28 17 0,000 0,03203714 0,0493485 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,03203714 0,04931741 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,03203714 0,04928635 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,03203714 0,04925533 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,03203714 0,04922435 ! myoblast differentiation GO:0045445 50 17 0,000 0,03203714 0,04919342 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,03203714 0,04916252 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,03203714 0,04913165 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,03203714 0,04910083 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,03203714 0,04907005 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,03203714 0,0490393 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,03203714 0,04900859 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,03203714 0,04897792 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,03203714 0,04894729 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,03203714 0,0489167 ! membrane budding GO:0006900 42 17 0,000 0,03203714 0,04888615 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,03203714 0,04885563 ! regulation of protein binding GO:0043393 33 17 0,000 0,03203714 0,04882516 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,03203714 0,04879472 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,03203714 0,04876431 ! genitalia development GO:0048806 32 17 0,000 0,03203714 0,04873395 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,03203714 0,04870362 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,03203714 0,04867334 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,03203714 0,04864309 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,03203714 0,04861287 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,03203714 0,0485827 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,03203714 0,04855256 ! steroid catabolic process GO:0006706 34 17 0,000 0,03203714 0,04852246 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,03203714 0,04849239 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,03203714 0,04846237 ! gas transport GO:0015669 26 17 0,000 0,03203714 0,04843238 ! organic cation transport GO:0015695 32 17 0,000 0,03203714 0,04840243 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,03203714 0,04837251 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,03203714 0,04834263 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,03203714 0,04831279 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,03388985 0,05107521 ! limbic system development GO:0021761 40 18 0,000 0,03388985 0,05104372 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,03388985 0,05101227 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,03388985 0,05098086 ! adult walking behavior GO:0007628 36 18 0,000 0,03388985 0,05094948 ! patterning of blood vessels GO:0001569 43 18 0,000 0,03388985 0,05091815 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,03388985 0,05088685 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,03388985 0,0508556 ! centrosome cycle GO:0007098 26 18 0,000 0,03388985 0,05082438 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,03388985 0,0507932 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,03388985 0,05076205 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,03388985 0,05073095 ! glycine metabolic process GO:0006544 30 18 0,000 0,03388985 0,05069988 ! glutamine metabolic process GO:0006541 29 18 0,000 0,03388985 0,05066886 ! response to retinoic acid GO:0032526 31 18 0,000 0,03388985 0,05063787 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,03388985 0,05060691 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,03388985 0,050576 ! DNA integration GO:0015074 32 18 0,000 0,03388985 0,05054512 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,03388985 0,05051428 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,03388985 0,05048348 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,03388985 0,05045272 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,03388985 0,05042199 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,03388985 0,0503913 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,03388985 0,05036065 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,03388985 0,05033004 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,03388985 0,05029946 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,03388985 0,05026892 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,03388985 0,05023842 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,03388985 0,05020795 ! detection of bacterium GO:0016045 22 18 0,000 0,03388985 0,05017752 ! nerve development GO:0021675 34 18 0,000 0,03388985 0,05014713 ! defense response to virus GO:0051607 43 18 0,000 0,03388985 0,05011677 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,03388985 0,05008646 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,03388985 0,05005617 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,03573908 0,05275563 ! positive regulation of translation GO:0045727 31 19 0,000 0,03573908 0,05272377 ! negative regulation of defense response GO:0031348 27 19 0,000 0,03573908 0,05269195 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,03573908 0,05266017 ! neuron maturation GO:0042551 46 19 0,000 0,03573908 0,05262843 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,03573908 0,05259672 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,03573908 0,05256506 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,03573908 0,05253343 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,03573908 0,05250184 ! inositol metabolic process GO:0006020 33 19 0,000 0,03573908 0,05247029 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,03573908 0,05243878 ! memory GO:0007613 34 19 0,000 0,03573908 0,0524073 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,03573908 0,05237586 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,03573908 0,05234446 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,03573908 0,0523131 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,03573908 0,05228177 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,03573908 0,05225049 ! cerebral cortex development GO:0021987 40 19 0,000 0,03573908 0,05221924 ! pigmentation during development GO:0048066 42 19 0,000 0,03573908 0,05218802 ! response to vitamin A GO:0033189 32 19 0,000 0,03573908 0,05215685 ! heme metabolic process GO:0042168 40 19 0,000 0,03573908 0,05212571 ! neuromuscular junction development GO:0007528 43 19 0,000 0,03573908 0,05209461 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,03573908 0,05206354 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,03573908 0,05203252 ! response to fungus GO:0009620 26 19 0,000 0,03573908 0,05200153 ! peptide cross-linking GO:0018149 39 19 0,000 0,03573908 0,05197057 ! protein export from nucleus GO:0006611 40 19 0,000 0,03573908 0,05193966 ! heart process GO:0003015 32 19 0,000 0,03573908 0,05190878 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,03573908 0,05187793 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,03573908 0,05184713 ! visual learning GO:0008542 38 19 0,000 0,03573908 0,05181636 ! cellular pigmentation GO:0033059 37 19 0,000 0,03573908 0,05178562 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,03573908 0,05175493 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,03573908 0,05172427 ! vitamin transport GO:0051180 31 19 0,000 0,03573908 0,05169364 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,03573908 0,05166305 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,03573908 0,0516325 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,03573908 0,05160199 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,03573908 0,05157151 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,03573908 0,05154106 ! cilium assembly GO:0042384 38 19 0,000 0,03573908 0,05151066 ! peptide hormone secretion GO:0030072 32 19 0,000 0,03573908 0,05148028 ! protein secretion GO:0009306 45 20 0,000 0,03758481 0,05410707 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,03758481 0,0540752 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,03758481 0,05404337 ! positive regulation of ossification GO:0045778 50 20 0,000 0,03758481 0,05401158 ! skin development GO:0043588 42 20 0,000 0,03758481 0,05397983 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,03758481 0,05394812 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,03758481 0,05391644 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,03758481 0,0538848 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,03758481 0,05385319 ! response to vitamin GO:0033273 36 20 0,000 0,03758481 0,05382163 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,03758481 0,0537901 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,03758481 0,0537586 ! bile acid metabolic process GO:0008206 34 20 0,000 0,03758481 0,05372715 ! response to alkaloid GO:0043279 38 20 0,000 0,03758481 0,05369573 ! retinoid metabolic process GO:0001523 34 20 0,000 0,03758481 0,05366434 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,03758481 0,053633 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,03758481 0,05360169 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,03758481 0,05357042 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,03758481 0,05353918 ! actin filament bundle formation GO:0051017 47 20 0,000 0,03758481 0,05350798 ! body fluid secretion GO:0007589 33 20 0,000 0,03758481 0,05347682 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,03758481 0,05344569 ! peptide secretion GO:0002790 38 20 0,000 0,03758481 0,0534146 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,03758481 0,05338354 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,03758481 0,05335252 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,03758481 0,05332154 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,03758481 0,05329059 ! cell-cell junction organization GO:0045216 43 20 0,000 0,03758481 0,05325968 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,03758481 0,05322881 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,03758481 0,05319797 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,03758481 0,05316716 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,03758481 0,0531364 ! regulation of glucose import GO:0046324 30 20 0,000 0,03758481 0,05310566 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,03758481 0,05307497 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,03758481 0,05304431 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,03758481 0,05301368 ! negative regulation of translation GO:0017148 32 20 0,000 0,03758481 0,05298309 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,03758481 0,05295253 ! regulation of cell killing GO:0031341 46 21 0,000 0,03942707 0,05551603 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,03942707 0,05548406 ! hormone secretion GO:0046879 39 21 0,000 0,03942707 0,05545211 ! cAMP metabolic process GO:0046058 41 21 0,000 0,03942707 0,05542021 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,03942707 0,05538834 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,03942707 0,05535651 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,03942707 0,05532471 ! ovarian follicle development GO:0001541 39 21 0,000 0,03942707 0,05529295 ! smooth muscle contraction GO:0006939 48 21 0,000 0,03942707 0,05526123 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,03942707 0,05522954 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,03942707 0,05519789 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,03942707 0,05516628 ! plasma membrane fusion GO:0045026 33 21 0,000 0,03942707 0,0551347 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,03942707 0,05510316 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,03942707 0,05507165 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,03942707 0,05504018 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,03942707 0,05500875 ! diencephalon development GO:0021536 36 21 0,000 0,03942707 0,05497735 ! collagen fibril organization GO:0030199 62 21 0,000 0,03942707 0,05494599 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,03942707 0,05491466 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,03942707 0,05488337 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,03942707 0,05485212 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,03942707 0,0548209 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,03942707 0,05478972 ! collagen catabolic process GO:0030574 29 21 0,000 0,03942707 0,05475857 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,03942707 0,05472745 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,03942707 0,05469638 ! sperm-egg recognition GO:0035036 23 21 0,000 0,03942707 0,05466534 ! actin filament-based movement GO:0030048 47 21 0,000 0,03942707 0,05463433 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,04126584 0,05714992 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,04126584 0,05711754 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,04126584 0,0570852 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,04126584 0,05705289 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,04126584 0,05702062 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,04126584 0,05698839 ! microtubule-based transport GO:0010970 59 22 0,000 0,04126584 0,05695619 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,04126584 0,05692403 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,04126584 0,05689191 ! vacuolar transport GO:0007034 41 22 0,000 0,04126584 0,05685982 ! central nervous system neuron development GO:0021954 47 22 0,000 0,04126584 0,05682777 ! fucose metabolic process GO:0006004 44 22 0,000 0,04126584 0,05679575 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,04126584 0,05676377 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,04126584 0,05673183 ! ureteric bud development GO:0001657 50 22 0,000 0,04126584 0,05669992 ! stem cell differentiation GO:0048863 57 22 0,000 0,04126584 0,05666805 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,04126584 0,05663621 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,04126584 0,05660441 ! cytolysis GO:0019835 27 22 0,000 0,04126584 0,05657265 ! renal system process GO:0003014 42 22 0,000 0,04126584 0,05654092 ! vasodilation GO:0042311 40 22 0,000 0,04126584 0,05650923 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,04126584 0,05647757 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,04126584 0,05644595 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,04126584 0,05641436 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,04126584 0,05638281 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,04126584 0,05635129 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,04126584 0,05631981 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,04126584 0,05628836 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,04126584 0,05625695 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,04126584 0,05622558 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,04126584 0,05619424 ! sarcomere organization GO:0045214 32 22 0,000 0,04126584 0,05616293 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,04126584 0,05613166 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,04126584 0,05610042 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,04126584 0,05606922 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,04126584 0,05603805 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,04126584 0,05600692 ! gut development GO:0048565 44 22 0,000 0,04126584 0,05597582 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,04126584 0,05594476 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,04126584 0,05591373 ! protein stabilization GO:0050821 41 22 0,000 0,04126584 0,05588274 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,04310116 0,0583358 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,04310116 0,0583035 ! gluconeogenesis GO:0006094 38 23 0,000 0,04310116 0,05827124 ! glycerol metabolic process GO:0006071 40 23 0,000 0,04310116 0,05823901 ! viral genome replication GO:0019079 44 23 0,000 0,04310116 0,05820681 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,04310116 0,05817465 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,04310116 0,05814253 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,04310116 0,05811044 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,04310116 0,05807839 ! regeneration GO:0031099 42 23 0,000 0,04310116 0,05804637 ! axis specification GO:0009798 43 23 0,000 0,04310116 0,05801439 ! visual behavior GO:0007632 46 23 0,000 0,04310116 0,05798245 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,04310116 0,05795054 ! response to ethanol GO:0045471 47 23 0,000 0,04310116 0,05791866 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,04310116 0,05788682 ! peroxisome organization GO:0007031 43 23 0,000 0,04310116 0,05785501 ! lysosome organization GO:0007040 47 23 0,000 0,04310116 0,05782324 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,04310116 0,05779151 ! vesicle targeting GO:0006903 49 23 0,000 0,04310116 0,0577598 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,04310116 0,05772814 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,04310116 0,05769651 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,04310116 0,05766491 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,04310116 0,05763335 ! DNA modification GO:0006304 36 23 0,000 0,04310116 0,05760182 ! fatty acid transport GO:0015908 47 23 0,000 0,04310116 0,05757032 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,04310116 0,05753887 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,04310116 0,05750744 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,04310116 0,05747605 ! hormone transport GO:0009914 41 23 0,000 0,04310116 0,05744469 ! cell-cell recognition GO:0009988 28 23 0,000 0,04310116 0,05741337 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,04310116 0,05738208 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,04310116 0,05735083 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,04310116 0,05731961 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,04493301 0,05972325 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,04493301 0,05969077 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,04493301 0,05965833 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,04493301 0,05962593 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,04493301 0,05959356 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,04493301 0,05956122 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,04493301 0,05952892 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,04493301 0,05949666 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,04493301 0,05946443 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,04493301 0,05943223 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,04493301 0,05940007 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,04493301 0,05936795 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,04493301 0,05933585 GO:0042278|purine nucleoside metabolic process, ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,04493301 0,0593038 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,04493301 0,05927178 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,04493301 0,05923979 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,04493301 0,05920784 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,04493301 0,05917592 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,04493301 0,05914404 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,04493301 0,05911219 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,04493301 0,05908037 ! pallium development GO:0021543 56 24 0,000 0,04493301 0,05904859 ! oogenesis GO:0048477 44 24 0,000 0,04493301 0,05901685 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,04493301 0,05898513 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,04493301 0,05895345 ! platelet activation GO:0030168 41 24 0,000 0,04493301 0,05892181 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,04493301 0,0588902 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,04493301 0,05885862 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,04493301 0,05882708 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,04493301 0,05879557 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,04493301 0,0587641 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,04493301 0,05873265 ! regulation of amine transport GO:0051952 41 24 0,000 0,04493301 0,05870125 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,0467614 0,06105724 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,0467614 0,06102463 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,0467614 0,06099204 ! leukocyte adhesion GO:0007159 55 25 0,000 0,0467614 0,0609595 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,0467614 0,06092699 ! phototransduction GO:0007602 37 25 0,000 0,0467614 0,06089451 ! keratinization GO:0031424 37 25 0,000 0,0467614 0,06086207 ! vacuole organization GO:0007033 49 25 0,000 0,0467614 0,06082966 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,0467614 0,06079728 ! receptor metabolic process GO:0043112 53 25 0,000 0,0467614 0,06076495 ! chromosome condensation GO:0030261 48 25 0,000 0,0467614 0,06073264 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,0467614 0,06070037 ! regulation of behavior GO:0050795 48 25 0,000 0,0467614 0,06066814 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,0467614 0,06063593 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,0467614 0,06060377 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,0467614 0,06057163 ! immunoglobulin production GO:0002377 62 25 0,000 0,0467614 0,06053953 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,0467614 0,06050747 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,0467614 0,06047544 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,0467614 0,06044344 ! liver development GO:0001889 55 25 0,000 0,0467614 0,06041147 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,04858634 0,06273596 ! myelination GO:0042552 50 26 0,000 0,04858634 0,06270282 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,04858634 0,06266971 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,04858634 0,06263664 ! molting cycle process GO:0022404 52 26 0,000 0,04858634 0,06260361 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,04858634 0,06257061 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,04858634 0,06253764 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,04858634 0,06250471 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,04858634 0,06247181 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,04858634 0,06243895 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,04858634 0,06240612 ! digestive system process GO:0022600 49 26 0,000 0,04858634 0,06237333 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,04858634 0,06234057 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,04858634 0,06230784 GO:0045936|negative regulation of phosphate metabolic process, ! osteoblast differentiation GO:0001649 63 26 0,000 0,04858634 0,06227515 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,04858634 0,0622425 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,04858634 0,06220987 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,04858634 0,06217729 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! response to estradiol stimulus GO:0032355 43 26 0,000 0,04858634 0,06214473 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,04858634 0,06211221 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,04858634 0,06207973 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,04858634 0,06204728 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,04858634 0,06201486 ! blastocyst development GO:0001824 50 26 0,000 0,04858634 0,06198247 ! telomere organization GO:0032200 46 26 0,000 0,04858634 0,06195012 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,04858634 0,06191781 ! neural tube closure GO:0001843 58 26 0,000 0,04858634 0,06188553 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,04858634 0,06185328 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,04858634 0,06182106 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,04858634 0,06178888 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,05040785 0,06407199 ! embryonic pattern specification GO:0009880 49 27 0,000 0,05040785 0,06403867 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,05040785 0,06400539 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,05040785 0,06397214 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,05040785 0,06393893 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,05040785 0,06390574 ! iron ion transport GO:0006826 65 27 0,000 0,05040785 0,0638726 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,05040785 0,06383949 ! superoxide metabolic process GO:0006801 41 27 0,000 0,05040785 0,06380641 ! tube lumen formation GO:0035148 59 27 0,000 0,05040785 0,06377337 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,05040785 0,06374036 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,05040785 0,06370738 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,05040785 0,06367444 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,05040785 0,06364153 ! leukocyte proliferation GO:0070661 59 27 0,000 0,05040785 0,06360866 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,05040785 0,06357582 ! neuron fate commitment GO:0048663 52 28 0,000 0,05222591 0,06583483 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,05222591 0,06580088 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,05222591 0,06576696 ! circadian rhythm GO:0007623 56 28 0,000 0,05222591 0,06573308 ! dendrite development GO:0016358 67 28 0,000 0,05222591 0,06569923 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,05222591 0,06566542 ! fat cell differentiation GO:0045444 57 28 0,000 0,05222591 0,06563164 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,05222591 0,0655979 ! sperm motility GO:0030317 37 28 0,000 0,05222591 0,06556419 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,05222591 0,06553051 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,05222591 0,06549687 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,05222591 0,06546327 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,05222591 0,0654297 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,05222591 0,06539616 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,05222591 0,06536266 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,05222591 0,06532919 ! glutathione metabolic process GO:0006749 42 28 0,000 0,05222591 0,06529576 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,05222591 0,06526236 ! lipid oxidation GO:0034440 48 28 0,000 0,05222591 0,06522899 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,05222591 0,06519566 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,05222591 0,06516236 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,05404055 0,06739207 ! translational initiation GO:0006413 66 29 0,000 0,05404055 0,06735769 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,05404055 0,06732334 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,05404055 0,06728902 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,05404055 0,06725474 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,05404055 0,0672205 ! primary neural tube formation GO:0014020 61 29 0,000 0,05404055 0,06718629 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,05404055 0,06715212 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,05404055 0,06711798 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,05404055 0,06708387 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,05404055 0,0670498 ! synaptogenesis GO:0007416 46 29 0,000 0,05404055 0,06701577 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,05404055 0,06698177 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,05404055 0,0669478 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,05404055 0,06691387 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,05585176 0,06912151 ! phenol metabolic process GO:0018958 56 30 0,000 0,05585176 0,06908651 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,05585176 0,06905155 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,05585176 0,06901662 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,05585176 0,06898173 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,05585176 0,06894687 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,05585176 0,06891205 ! acute-phase response GO:0006953 50 30 0,000 0,05585176 0,06887726 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,05585176 0,06884251 ! myofibril assembly GO:0030239 50 30 0,000 0,05585176 0,0688078 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,05585176 0,06877311 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,05585176 0,06873847 ! cell fate determination GO:0001709 64 30 0,000 0,05585176 0,06870386 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,05585176 0,06866928 ! phospholipid transport GO:0015914 65 30 0,000 0,05585176 0,06863474 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,05585176 0,06860023 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,05585176 0,06856576 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,05585176 0,06853132 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,05585176 0,06849692 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,05585176 0,06846255 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,05585176 0,06842821 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,05765956 0,07060767 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,05765956 0,0705723 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,05765956 0,07053696 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,05765956 0,07050165 ! cell junction assembly GO:0034329 85 31 0,000 0,05765956 0,07046639 ! regulation of innate immune response GO:0045088 57 31 0,000 0,05765956 0,07043115 ! ovulation cycle process GO:0022602 55 31 0,000 0,05765956 0,07039595 ! peptide transport GO:0015833 60 31 0,000 0,05765956 0,07036079 ! male gonad development GO:0008584 56 31 0,000 0,05765956 0,07032566 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,05765956 0,07029057 ! detection of light stimulus GO:0009583 44 31 0,000 0,05765956 0,07025551 ! natural killer cell activation GO:0030101 50 31 0,000 0,05765956 0,07022049 ! ensheathment of neurons GO:0007272 64 31 0,000 0,05765956 0,0701855 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,05765956 0,07015055 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,05765956 0,07011563 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,05765956 0,07008075 ! eye morphogenesis GO:0048592 65 31 0,000 0,05765956 0,0700459 ! response to heat GO:0009408 54 31 0,000 0,05765956 0,07001109 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,05765956 0,06997631 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,05946395 0,0721303 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,05946395 0,0720945 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,05946395 0,07205874 ! spindle organization GO:0007051 50 32 0,000 0,05946395 0,07202301 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,05946395 0,07198732 ! metanephros development GO:0001656 81 32 0,000 0,05946395 0,07195167 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,05946395 0,07191605 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,05946395 0,07188046 ! muscle cell development GO:0055001 52 32 0,000 0,05946395 0,07184492 ! mesoderm formation GO:0001707 73 32 0,000 0,05946395 0,0718094 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,05946395 0,07177392 ! ovulation cycle GO:0042698 57 32 0,000 0,05946395 0,07173848 ! peripheral nervous system development GO:0007422 68 32 0,000 0,05946395 0,07170307 ! BMP signaling pathway GO:0030509 71 32 0,000 0,05946395 0,0716677 ! hindbrain development GO:0030902 65 32 0,000 0,05946395 0,07163236 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,05946395 0,07159705 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,05946395 0,07156178 ! gene silencing GO:0016458 71 32 0,000 0,05946395 0,07152655 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,06126493 0,0736566 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,06126493 0,07362037 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,06126493 0,07358418 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,06126493 0,07354802 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,06126493 0,07351189 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,06126493 0,07347581 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,06126493 0,07343975 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,06126493 0,07340374 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,06126493 0,07336775 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,06126493 0,07333181 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,06306251 0,07544648 ! glial cell differentiation GO:0010001 67 34 0,000 0,06306251 0,07540955 ! post-embryonic development GO:0009791 76 34 0,000 0,06306251 0,07537266 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,06306251 0,0753358 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,06306251 0,07529898 ! spliceosome assembly GO:0000245 75 34 0,000 0,06306251 0,07526219 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,06306251 0,07522545 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,06306251 0,07518873 ! formation of primary germ layer GO:0001704 76 34 0,000 0,06306251 0,07515206 ! cell fate specification GO:0001708 56 34 0,000 0,06306251 0,07511541 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,06306251 0,07507881 ! adult locomotory behavior GO:0008344 62 34 0,000 0,06306251 0,07504224 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,0648567 0,07713969 ! negative regulation of secretion GO:0051048 68 35 0,000 0,0648567 0,07710215 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,0648567 0,07706465 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,0648567 0,07702719 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,0648567 0,07698976 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,0648567 0,07695237 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,0648567 0,07691501 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,0648567 0,07687769 ! ceramide metabolic process GO:0006672 72 35 0,000 0,0648567 0,07684041 ! telencephalon development GO:0021537 81 35 0,000 0,0648567 0,07680316 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,0648567 0,07676595 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,0648567 0,07672878 ! vesicle localization GO:0051648 70 35 0,000 0,0648567 0,07669164 ! regulation of muscle development GO:0048634 82 36 0,000 0,06664751 0,0787711 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,06664751 0,07873301 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,06664751 0,07869496 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,06664751 0,07865694 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,06664751 0,07861896 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,06664751 0,07858102 ! positive regulation of cell development GO:0010720 85 36 0,000 0,06664751 0,07854311 ! protein targeting to membrane GO:0006612 75 36 0,000 0,06664751 0,07850524 ! regulation of proteolysis GO:0030162 77 36 0,000 0,06664751 0,0784674 ! aerobic respiration GO:0009060 56 36 0,000 0,06664751 0,07842961 ! cytokine production GO:0001816 68 36 0,000 0,06664751 0,07839185 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,06664751 0,07835412 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,06843494 0,08041681 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,06843494 0,08037815 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,06843494 0,08033952 ! sister chromatid segregation GO:0000819 65 37 0,000 0,06843494 0,08030094 ! odontogenesis GO:0042476 74 37 0,000 0,06843494 0,08026239 ! actomyosin structure organization GO:0031032 68 37 0,000 0,06843494 0,08022387 ! cell junction organization GO:0034330 96 37 0,000 0,06843494 0,08018539 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,06843494 0,08014696 ! female gonad development GO:0008585 71 37 0,000 0,06843494 0,08010855 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,06843494 0,08007019 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,06843494 0,08003186 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,06843494 0,07999356 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,07021899 0,08203969 ! meiosis I GO:0007127 74 38 0,000 0,07021899 0,08200047 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,07021899 0,0819613 ! organic anion transport GO:0015711 82 38 0,000 0,07021899 0,08192216 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,07021899 0,08188305 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,07021899 0,08184399 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,07021899 0,08180496 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,07021899 0,08176596 ! regulation of protein stability GO:0031647 77 38 0,000 0,07021899 0,08172701 ! spermatid development GO:0007286 69 38 0,000 0,07021899 0,08168809 ! glycogen metabolic process GO:0005977 63 38 0,000 0,07021899 0,08164921 ! pigment metabolic process GO:0042440 87 38 0,000 0,07021899 0,08161037 ! neural tube formation GO:0001841 79 38 0,000 0,07021899 0,08157156 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,07199968 0,08360039 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,07199968 0,08356067 ! negative regulation of binding GO:0051100 71 39 0,000 0,07199968 0,08352099 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,07199968 0,08348135 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,07199968 0,08344175 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,07199968 0,08340219 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,07199968 0,08336266 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,07199968 0,08332317 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,07199968 0,08328372 ! glucan metabolic process GO:0044042 64 39 0,000 0,07199968 0,0832443 GO:0006073|cellular glucan metabolic process, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,07377701 0,08525886 ! learning GO:0007612 82 40 0,000 0,07377701 0,08521855 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,07377701 0,08517827 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,07377701 0,08513804 ! mismatch repair GO:0006298 58 40 0,000 0,07377701 0,08509784 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,07377701 0,08505768 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,07377701 0,08501756 ! RNA export from nucleus GO:0006405 61 41 0,000 0,07555098 0,08702077 ! mRNA catabolic process GO:0006402 79 41 0,000 0,07555098 0,08697976 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,07555098 0,08693879 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,07555098 0,08689785 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,07555098 0,08685696 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,07555098 0,08681611 ! gliogenesis GO:0042063 91 41 0,000 0,07555098 0,08677529 ! feeding behavior GO:0007631 69 41 0,000 0,07555098 0,08673451 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,07555098 0,08669377 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,07555098 0,08665307 ! spermatid differentiation GO:0048515 73 41 0,000 0,07555098 0,08661241 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,07555098 0,08657178 ! RNA modification GO:0009451 64 41 0,000 0,07555098 0,0865312 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,07732161 0,08851766 ! ear morphogenesis GO:0042471 64 42 0,000 0,07732161 0,0884762 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,07732161 0,08843478 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,07732161 0,08839339 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,07732161 0,08835205 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,07732161 0,08831074 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,07732161 0,08826948 ! regulation of protein secretion GO:0050708 77 42 0,000 0,07732161 0,08822825 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,07732161 0,08818706 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,07732161 0,08814591 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,07908889 0,09011854 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,07908889 0,09007653 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,07908889 0,09003456 ! regulation of tube size GO:0035150 76 43 0,000 0,07908889 0,08999262 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,07908889 0,08995073 ! glucose transport GO:0015758 66 43 0,000 0,07908889 0,08990887 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,07908889 0,08986705 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,07908889 0,08982527 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,07908889 0,08978353 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,07908889 0,08974183 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,07908889 0,08970017 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,07908889 0,08965854 ! ion transmembrane transport GO:0034220 79 43 0,000 0,07908889 0,08961696 ! neuron migration GO:0001764 85 43 0,000 0,07908889 0,08957541 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,08085284 0,09153081 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,08085284 0,09148841 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,08085284 0,09144606 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,08085284 0,09140374 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,08085284 0,09136146 ! hexose transport GO:0008645 68 44 0,000 0,08085284 0,09131923 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,08085284 0,09127703 ! striated muscle contraction GO:0006941 85 44 0,000 0,08085284 0,09123487 ! phagocytosis GO:0006909 105 44 0,000 0,08085284 0,09119275 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,08085284 0,09115066 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,08261346 0,09309256 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,08261346 0,09304965 ! regulation of epithelial cell proliferation GO:0050678 122 45 0,000 0,08261346 0,09300677 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,08261346 0,09296392 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,08261346 0,09292112 ! biopolymer methylation GO:0043414 91 45 0,000 0,08261346 0,09287836 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,08261346 0,09283564 ! female gamete generation GO:0007292 71 45 0,000 0,08261346 0,09279296 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,08261346 0,09275031 ! polyol metabolic process GO:0019751 77 45 0,000 0,08261346 0,09270771 ! developmental growth GO:0048589 88 45 0,000 0,08261346 0,09266514 ! maintenance of location in cell GO:0051651 101 45 0,000 0,08261346 0,09262262 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,08437076 0,09454943 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 0,000 0,08437076 0,09450608 ! glycolysis GO:0006096 71 46 0,000 0,08437076 0,09446277 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,08437076 0,09441949 ! leukocyte migration GO:0050900 75 46 0,000 0,08437076 0,09437626 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,08437076 0,09433307 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,08437076 0,09428992 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,08437076 0,0942468 ! pigmentation GO:0043473 103 46 0,000 0,08437076 0,09420373 ! cell growth GO:0016049 90 46 0,000 0,08437076 0,09416069 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,08437076 0,0941177 ! neural tube development GO:0021915 91 47 0,000 0,08612474 0,09603046 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,08612474 0,09598665 ! positive regulation of cell cycle GO:0045787 96 48 0,000 0,08787541 0,09789312 ! positive regulation of defense response GO:0031349 88 48 0,000 0,08787541 0,0978485 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,08787541 0,09780393 ! cellular component disassembly GO:0022411 89 48 0,000 0,08787541 0,09775939 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,08787541 0,09771489 ! endosome transport GO:0016197 127 48 0,000 0,08787541 0,09767044 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,08787541 0,09762602 ! male sex differentiation GO:0046661 93 48 0,000 0,08787541 0,09758164 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,08787541 0,09753731 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,08787541 0,09749301 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,08787541 0,09744876 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,08787541 0,09740454 ! methylation GO:0032259 97 48 0,000 0,08787541 0,09736037 ! response to calcium ion GO:0051592 94 49 0,000 0,08962277 0,09925133 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,08962277 0,09920636 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,08962277 0,09916143 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,08962277 0,09911654 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,08962277 0,09907169 ! regulation of action potential GO:0001508 102 50 0,000 0,09136684 0,10095395 ! regulation of ion transport GO:0043269 86 50 0,000 0,09136684 0,10090831 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,09136684 0,10086271 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,09136684 0,10081716 ! regulation of ossification GO:0030278 123 50 0,000 0,09136684 0,10077164 ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,09136684 0,10072617 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,09136684 0,10068073 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,09136684 0,10063534 ! peptide metabolic process GO:0006518 80 51 0,000 0,09310761 0,10250649 ! response to temperature stimulus GO:0009266 84 51 0,000 0,09310761 0,10246031 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,09310761 0,10241418 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,09310761 0,10236809 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,0948451 0,10423148 ! Notch signaling pathway GO:0007219 111 52 0,000 0,0948451 0,10418461 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,0948451 0,10413779 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,0948451 0,10409101 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,0948451 0,10404427 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,0948451 0,10399757 ! excretion GO:0007588 87 52 0,000 0,0948451 0,10395091 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,0948451 0,1039043 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,0948451 0,10385772 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,0948451 0,10381119 ! amino acid activation GO:0043038 98 52 0,000 0,0948451 0,1037647 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,09657931 0,10561471 ! inner ear development GO:0048839 89 53 0,000 0,09657931 0,10556745 ! chromatin remodeling GO:0006338 122 53 0,000 0,09657931 0,10552024 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,09657931 0,10547307 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,09657931 0,10542594 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,09657931 0,10537885 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! synapse organization GO:0050808 102 53 0,000 0,09657931 0,10533181 ! regulation of translational initiation GO:0006446 87 54 0,000 0,09831024 0,10717177 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,09831024 0,10712396 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,09831024 0,1070762 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,09831024 0,10702849 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,09831024 0,10698081 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,09831024 0,10693318 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,09831024 0,10688559 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,09831024 0,10683805 ! RNA catabolic process GO:0006401 103 55 0,000 0,10003791 0,10866724 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,10003791 0,10861894 ! cell recognition GO:0008037 98 55 0,000 0,10003791 0,10857069 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,10003791 0,10852248 ! cell maturation GO:0048469 107 55 0,000 0,10003791 0,10847431 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,10003791 0,10842618 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,10176232 0,11024627 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,10176232 0,1101974 ! glucose catabolic process GO:0006007 88 56 0,000 0,10176232 0,11014858 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,10176232 0,1100998 ! RNA elongation GO:0006354 90 56 0,000 0,10176232 0,11005106 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 0,000 0,10348347 0,11186288 ! chloride transport GO:0006821 102 57 0,000 0,10348347 0,11181341 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,10348347 0,11176397 ! muscle fiber development GO:0048747 131 57 0,000 0,10348347 0,11171459 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,10348347 0,11166524 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,10348347 0,11161594 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,10520137 0,11341877 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,10520137 0,11336874 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,10520137 0,11331876 ! gastrulation GO:0007369 122 58 0,000 0,10520137 0,11326881 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,10520137 0,11321892 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,10520137 0,11316906 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,10520137 0,11311925 ! maintenance of location GO:0051235 124 58 0,000 0,10520137 0,11306948 ! nuclear export GO:0051168 110 59 0,000 0,10691602 0,11486185 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,10862744 0,11664916 ! DNA catabolic process GO:0006308 94 60 0,000 0,10862744 0,11659791 ! regulation of endocytosis GO:0030100 104 60 0,000 0,10862744 0,1165467 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,10862744 0,11649554 ! adult behavior GO:0030534 104 60 0,000 0,10862744 0,11644442 ! kidney development GO:0001822 133 60 0,000 0,10862744 0,11639335 ! positive regulation of secretion GO:0051047 110 61 0,000 0,11033563 0,11817183 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,11033563 0,11812005 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,11033563 0,11806831 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,11033563 0,11801661 ! regulation of heart contraction GO:0008016 123 61 0,000 0,11033563 0,11796497 ! camera-type eye development GO:0043010 126 61 0,000 0,11033563 0,11791336 ! proton transport GO:0015992 117 61 0,000 0,11033563 0,1178618 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,11033563 0,11781029 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,11204059 0,11957849 ! tRNA processing GO:0008033 102 62 0,000 0,11204059 0,11952627 ! regulation of mitosis GO:0007088 112 63 0,000 0,11374234 0,12128875 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,11374234 0,12123583 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,11374234 0,12118296 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,11374234 0,12113013 ! hydrogen transport GO:0006818 121 64 0,000 0,11544087 0,12288542 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,11544087 0,1228319 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,11544087 0,12277842 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,11713619 0,12452729 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,11713619 0,12447312 GO:0048609|reproductive process in a multicellular organism, ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,11713619 0,124419 ! ear development GO:0043583 114 66 0,000 0,11882831 0,12616148 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,11882831 0,12610667 ! gonad development GO:0008406 115 66 0,000 0,11882831 0,12605191 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,11882831 0,1259972 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,12051723 0,12773258 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,12051723 0,12767719 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,12051723 0,12762185 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,12051723 0,12756655 ! secondary metabolic process GO:0019748 125 67 0,000 0,12051723 0,1275113 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,12220297 0,1292389 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,12220297 0,12918297 ! hexose catabolic process GO:0019320 113 68 0,000 0,12220297 0,1291271 ! extracellular matrix organization GO:0030198 146 68 0,000 0,12220297 0,12907127 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,12220297 0,12901549 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,12220297 0,12895976 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,12220297 0,12890408 ! regulation of lipase activity GO:0060191 137 68 0,000 0,12220297 0,12884845 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,12220297 0,12879286 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,12388552 0,13050984 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,12388552 0,13045359 ! urogenital system development GO:0001655 149 69 0,000 0,12388552 0,13039738 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,12388552 0,13034122 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 0,000 0,12388552 0,13028512 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,12388552 0,13022905 ! developmental maturation GO:0021700 128 69 0,000 0,12388552 0,13017304 ! single fertilization GO:0007338 83 69 0,000 0,12388552 0,13011708 ! cell redox homeostasis GO:0045454 114 70 0,000 0,12556489 0,13182425 ! germ cell development GO:0007281 133 70 0,000 0,12556489 0,13176763 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,12724109 0,1334693 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,12724109 0,13341201 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,12724109 0,13335478 ! appendage morphogenesis GO:0035107 150 72 0,000 0,12891413 0,13505027 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,12891413 0,13499238 ! actin filament organization GO:0007015 167 72 0,000 0,12891413 0,13493454 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,12891413 0,13487675 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,12891413 0,13481902 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,12891413 0,13476133 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,12891413 0,13470369 ! appendage development GO:0048736 151 73 0,000 0,13058401 0,13639022 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,13058401 0,13633194 ! regulation of immune effector process GO:0002697 156 73 0,000 0,13058401 0,1362737 ! amino acid transport GO:0006865 148 74 0,000 0,13225073 0,13795411 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,13225073 0,13789523 ! transition metal ion transport GO:0000041 143 75 0,000 0,1339143 0,13957024 ! reproductive structure development GO:0048608 131 75 0,000 0,1339143 0,13951072 ! eye development GO:0001654 155 75 0,000 0,1339143 0,13945125 ! axon guidance GO:0007411 162 75 0,000 0,1339143 0,13939184 ! rhythmic process GO:0048511 142 75 0,000 0,1339143 0,13933247 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,13557473 0,14100003 ! learning or memory GO:0007611 161 76 0,000 0,13557473 0,14094003 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,13557473 0,14088008 ! regulation of blood pressure GO:0008217 134 76 0,000 0,13557473 0,14082018 ! amine catabolic process GO:0009310 136 77 0,000 0,13723203 0,14248102 ! neurotransmitter transport GO:0006836 142 77 0,000 0,13723203 0,14242049 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,13723203 0,14236002 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,13723203 0,14229959 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,13723203 0,14223922 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,13723203 0,1421789 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,13888619 0,14383169 ! antigen processing and presentation GO:0019882 117 78 0,000 0,13888619 0,14377075 ! fertilization GO:0009566 99 78 0,000 0,13888619 0,14370985 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,13888619 0,14364901 ! blood coagulation GO:0007596 151 79 0,000 0,14053723 0,14529516 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,14053723 0,14523369 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,14053723 0,14517228 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,14053723 0,14511093 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,14053723 0,14504962 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,14218515 0,14668848 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,14218515 0,14662656 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,14218515 0,14656469 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,14218515 0,14650288 ! meiosis GO:0007126 143 81 0,000 0,14382996 0,14813515 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,14382996 0,14807273 ! positive regulation of phosphorylation GO:0042327 149 81 0,000 0,14382996 0,14801035 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,14382996 0,14794803 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,14547165 0,14957376 ! meiotic cell cycle GO:0051321 144 82 0,000 0,14547165 0,14951083 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,14711025 0,15113135 ! exocytosis GO:0006887 153 83 0,000 0,14711025 0,15106782 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,14711025 0,15100435 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 0,000 0,14711025 0,15094093 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,14711025 0,15087756 ! inorganic anion transport GO:0015698 156 83 0,000 0,14711025 0,15081424 ! response to metal ion GO:0010038 158 84 0,000 0,14874575 0,15242696 ! response to nutrient GO:0007584 135 84 0,000 0,14874575 0,15236305 ! digestion GO:0007586 130 84 0,000 0,14874575 0,15229919 ! regulation of ligase activity GO:0051340 147 84 0,000 0,14874575 0,15223539 ! hemostasis GO:0007599 165 85 0,000 0,15037816 0,15384165 ! negative regulation of transport GO:0051051 164 85 0,000 0,15037816 0,15377725 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,15037816 0,15371291 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,15037816 0,15364862 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,15037816 0,15358439 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,15037816 0,15352021 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,15200749 0,15511875 ! regulation of lyase activity GO:0051339 169 86 0,000 0,15200749 0,15505399 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,15200749 0,15498927 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,15363374 0,15658207 ! alcohol catabolic process GO:0046164 142 87 0,000 0,15363374 0,15651677 ! nucleosome assembly GO:0006334 126 87 0,000 0,15363374 0,15645153 ! regulation of protein transport GO:0051223 165 87 0,000 0,15363374 0,15638634 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,15525691 0,15797278 ! amine biosynthetic process GO:0009309 146 88 0,000 0,15525691 0,15790701 ! sensory perception of smell GO:0007608 117 88 0,000 0,15525691 0,1578413 ! chromatin assembly GO:0031497 128 88 0,000 0,15525691 0,15777564 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,15525691 0,15771004 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,15687702 0,15928951 ! tube morphogenesis GO:0035239 194 89 0,000 0,15687702 0,15922333 ! cellular defense response GO:0006968 123 89 0,000 0,15687702 0,15915721 ! regulation of neurological system process GO:0031644 175 89 0,000 0,15687702 0,15909114 ! response to inorganic substance GO:0010035 173 90 0,000 0,15849407 0,16066432 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,15849407 0,16059768 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,15849407 0,1605311 ! response to unfolded protein GO:0006986 139 90 0,000 0,15849407 0,16046457 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,15849407 0,1603981 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,16010806 0,16196438 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,16010806 0,16189734 ! defense response to bacterium GO:0042742 112 91 0,000 0,16010806 0,16183036 ! bone development GO:0060348 206 92 0,000 0,161719 0,16339103 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,161719 0,16332348 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,16332689 0,16487917 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,16332689 0,16481107 ! vitamin metabolic process GO:0006766 153 93 0,000 0,16332689 0,16474302 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,16493175 0,16629313 ! female pregnancy GO:0007565 166 94 0,000 0,16493175 0,16622453 ! sterol metabolic process GO:0016125 166 94 0,000 0,16493175 0,16615598 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,16493175 0,16608749 ! regulation of defense response GO:0031347 171 95 0,000 0,16653357 0,16763144 ! nucleosome organization GO:0034728 143 95 0,000 0,16653357 0,1675624 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,16653357 0,16749342 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,16653357 0,16742449 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,16653357 0,16735562 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,16653357 0,16728681 ! sex differentiation GO:0007548 171 96 0,000 0,16813237 0,16882342 ! response to protein stimulus GO:0051789 158 96 0,000 0,16813237 0,16875406 ! regulation of T cell activation GO:0050863 175 96 0,000 0,16813237 0,16868475 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,16972814 0,17021587 ! transcription initiation GO:0006352 171 97 0,000 0,16972814 0,17014602 ! regulation of protein localization GO:0032880 188 97 0,000 0,16972814 0,17007623 ! interphase of mitotic cell cycle GO:0051329 224 98 0,000 0,1713209 0,17160187 ! forebrain development GO:0030900 210 98 0,000 0,1713209 0,17153154 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,1713209 0,17146127 ! mRNA transport GO:0051028 185 100 0,000 0,17449739 0,17456884 ! hormone metabolic process GO:0042445 171 100 0,000 0,17449739 0,17449739