pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6937-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 1,185E-09 2,726E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 7,000 4,942E-09 5,683E-06 ! interphase of mitotic cell cycle GO:0051329 156 86 8,000 2,076E-08 1,592E-05 ! interphase GO:0051325 159 88 8,000 2,546E-08 1,464E-05 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 3,000 5,041E-08 2,319E-05 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 3,000 2,324E-07 8,91E-05 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 7,671E-07 2,52E-04 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 3,000 1,076E-06 3,094E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 1,196E-06 3,057E-04 GO:0045936|negative regulation of phosphate metabolic process, ! response to UV GO:0009411 75 46 5,000 1,379E-06 3,171E-04 ! positive regulation of cellular catabolic process GO:0031331 22 12 3,000 1,605E-06 3,355E-04 ! germ cell development GO:0007281 68 49 5,000 2,019E-06 3,87E-04 ! positive regulation of catabolic process GO:0009896 40 28 4,000 2,172E-06 3,843E-04 ! regulation of monooxygenase activity GO:0032768 26 13 3,000 2,304E-06 3,785E-04 ! positive regulation of cell migration GO:0030335 92 51 5,000 2,568E-06 3,938E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 4,453E-06 6,401E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 4,453E-06 6,025E-04 ! positive regulation of cell motion GO:0051272 99 56 5,000 4,486E-06 5,732E-04 ! cell cycle arrest GO:0007050 150 86 6,000 4,531E-06 5,484E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 7,487E-06 8,61E-04 ! cytokinesis during cell cycle GO:0033205 9 6 2,000 8,856E-06 9,699E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 2,000 8,856E-06 9,258E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 9,569E-06 9,569E-04 ! negative regulation of cell size GO:0045792 108 64 5,000 9,848E-06 9,437E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 4,000 1,189E-05 1,094E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 1,497E-05 1,324E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,541E-05 1,313E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 1,541E-05 1,266E-03 ! positive regulation of monooxygenase activity GO:0032770 11 7 2,000 1,541E-05 1,222E-03 ! regulation of catabolic process GO:0009894 106 70 5,000 1,658E-05 1,271E-03 ! response to hypoxia GO:0001666 132 72 5,000 1,951E-05 1,448E-03 ! vasculogenesis GO:0001570 33 22 3,000 2,233E-05 1,605E-03 ! response to oxygen levels GO:0070482 137 74 5,000 2,284E-05 1,592E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 2,43E-05 1,644E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 2,452E-05 1,611E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,452E-05 1,566E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,452E-05 1,524E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,452E-05 1,484E-03 ! negative regulation of growth GO:0045926 123 75 5,000 2,467E-05 1,455E-03 ! regulation of cellular catabolic process GO:0031329 36 24 3,000 3,205E-05 1,843E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 3,205E-05 1,798E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 3,000 3,205E-05 1,755E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 2,000 3,657E-05 1,956E-03 ! regulation of glycolysis GO:0006110 15 9 2,000 3,657E-05 1,911E-03 ! oocyte differentiation GO:0009994 12 9 2,000 3,657E-05 1,869E-03 GO:0048599|oocyte development, ! embryonic placenta development GO:0001892 12 9 2,000 3,657E-05 1,828E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 5,194E-05 2,542E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 5,194E-05 2,489E-03 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 2,000 5,194E-05 2,438E-03 ! negative regulation of protein transport GO:0051224 49 27 3,000 5,2E-05 2,392E-03 ! placenta development GO:0001890 37 28 3,000 6,03E-05 2,72E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 7,102E-05 3,141E-03 ! T cell homeostasis GO:0043029 20 11 2,000 7,102E-05 3,082E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 7,102E-05 3,025E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 7,734E-05 3,234E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 7,734E-05 3,176E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 8,411E-05 3,394E-03 ! actin filament organization GO:0007015 95 59 4,000 9,134E-05 3,622E-03 ! regulation of binding GO:0051098 151 95 5,000 9,389E-05 3,66E-03 ! angiogenesis GO:0001525 149 95 5,000 9,389E-05 3,599E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 2,000 9,415E-05 3,55E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! response to gamma radiation GO:0010332 20 12 2,000 9,415E-05 3,493E-03 ! response to light stimulus GO:0009416 153 96 5,000 9,952E-05 3,633E-03 ! regulation of protein stability GO:0031647 48 32 3,000 1,034E-04 3,716E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 1,072E-04 3,793E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 1,159E-04 4,039E-03 ! negative regulation of DNA binding GO:0043392 54 33 3,000 1,17E-04 4,015E-03 ! cytokinesis GO:0000910 52 33 3,000 1,17E-04 3,956E-03 ! lymphocyte homeostasis GO:0002260 24 13 2,000 1,217E-04 4,057E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 1,318E-04 4,33E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 1,479E-04 4,791E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 1,54E-04 4,92E-03 ! negative regulation of binding GO:0051100 58 36 3,000 1,654E-04 5,211E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 1,915E-04 5,95E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 1,915E-04 5,871E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,915E-04 5,794E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,915E-04 5,719E-03 ! positive regulation of oxidoreductase activity GO:0051353 21 15 2,000 1,915E-04 5,645E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 1,915E-04 5,574E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,915E-04 5,504E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 2,000 1,915E-04 5,436E-03 ! developmental growth GO:0048589 62 39 3,000 2,268E-04 6,362E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 2,343E-04 6,493E-03 ! oogenesis GO:0048477 23 16 2,000 2,343E-04 6,415E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 2,343E-04 6,34E-03 ! mitochondrion organization GO:0007005 104 73 4,000 2,514E-04 6,723E-03 ! endosome transport GO:0016197 71 41 3,000 2,76E-04 7,296E-03 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 2,829E-04 7,394E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,829E-04 7,311E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 2,829E-04 7,23E-03 ! response to nutrient GO:0007584 104 75 4,000 2,853E-04 7,211E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 3,032E-04 7,58E-03 ! regulation of DNA binding GO:0051101 119 77 4,000 3,226E-04 7,978E-03 ! gland development GO:0048732 148 77 4,000 3,226E-04 7,894E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 3,323E-04 8,045E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 3,376E-04 8,088E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 3,634E-04 8,616E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 3,964E-04 9,304E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 3,986E-04 9,261E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 3,986E-04 9,168E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 3,986E-04 9,077E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 3,986E-04 8,988E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 3,986E-04 8,901E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 3,986E-04 8,815E-03 ! sex determination GO:0007530 29 19 2,000 3,986E-04 8,731E-03 ! regulation of cell cycle process GO:0010564 122 81 4,000 4,082E-04 8,857E-03 ! regulation of cell adhesion GO:0030155 159 83 4,000 4,569E-04 9,821E-03 ! hindlimb morphogenesis GO:0035137 32 20 2,000 4,663E-04 9,931E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 4,69E-04 9,896E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 5,099E-04 0,01066083 ! regulation of protein localization GO:0032880 132 85 4,000 5,099E-04 0,01056479 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 5,41E-04 0,01110907 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 5,41E-04 0,01101076 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 5,41E-04 0,01091418 ! cell aging GO:0007569 32 21 2,000 5,41E-04 0,01081927 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 2,000 5,41E-04 0,010726 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 5,41E-04 0,01063433 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 5,41E-04 0,01054421 ! regulation of intracellular transport GO:0032386 78 49 3,000 5,505E-04 0,01063942 ! embryonic hemopoiesis GO:0035162 10 5 1,000 5,83E-04 0,01117393 ! response to food GO:0032094 5 5 1,000 5,83E-04 0,01108159 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 5,83E-04 0,01099075 ! response to UV-C GO:0010225 6 5 1,000 5,83E-04 0,0109014 ! positive regulation of chemokine production GO:0032722 7 5 1,000 5,83E-04 0,01081348 ! regulation of respiratory burst GO:0060263 8 5 1,000 5,83E-04 0,01072698 ! triglyceride catabolic process GO:0019433 6 5 1,000 5,83E-04 0,01064184 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 5,83E-04 0,01055805 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 5,83E-04 0,01047556 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 5,83E-04 0,01039436 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,83E-04 0,0103144 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 5,83E-04 0,01023566 ! anagen GO:0042640 6 5 1,000 5,83E-04 0,01015812 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 5,83E-04 0,01008174 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,83E-04 0,01000651 ! microvillus organization GO:0032528 7 5 1,000 5,83E-04 9,932E-03 GO:0030033|microvillus assembly, ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 5,83E-04 9,859E-03 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 5,83E-04 9,787E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,83E-04 9,716E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 5,83E-04 9,647E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 5,83E-04 9,578E-03 GO:0045686|negative regulation of glial cell differentiation, ! centrosome duplication GO:0051298 5 5 1,000 5,83E-04 9,51E-03 ! regulation of dendrite development GO:0050773 12 5 1,000 5,83E-04 9,443E-03 ! positive regulation of growth GO:0045927 67 50 3,000 5,948E-04 9,567E-03 ! molting cycle process GO:0022404 40 22 2,000 6,229E-04 9,948E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 6,229E-04 9,88E-03 GO:0010810|regulation of cell-substrate adhesion, ! leukocyte homeostasis GO:0001776 33 22 2,000 6,229E-04 9,812E-03 ! blastocyst development GO:0001824 37 22 2,000 6,229E-04 9,745E-03 ! reproductive developmental process GO:0003006 127 89 4,000 6,295E-04 9,783E-03 ! regulation of protein catabolic process GO:0042176 77 51 3,000 6,416E-04 9,904E-03 ! aging GO:0007568 79 52 3,000 6,909E-04 0,01059403 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 7,122E-04 0,01084884 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 7,122E-04 0,01077746 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 7,691E-04 0,01156146 ! DNA catabolic process GO:0006308 67 54 3,000 7,976E-04 0,01191148 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 8,094E-04 0,01201076 ! mitochondrial membrane organization GO:0007006 39 24 2,000 8,094E-04 0,01193377 ! activation of MAPKKK activity GO:0000185 10 6 1,000 8,701E-04 0,01274601 ! pigment granule organization GO:0048753 11 6 1,000 8,701E-04 0,01266534 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 8,701E-04 0,01258568 ! glycerol ether catabolic process GO:0044269 8 6 1,000 8,701E-04 0,01250702 GO:0046464|acylglycerol catabolic process, ! neuron apoptosis GO:0051402 8 6 1,000 8,701E-04 0,01242934 ! spindle checkpoint GO:0031577 14 6 1,000 8,701E-04 0,01235262 ! hair follicle maturation GO:0048820 7 6 1,000 8,701E-04 0,01227683 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 8,701E-04 0,01220198 ! blastocyst growth GO:0001832 15 6 1,000 8,701E-04 0,01212802 ! negative regulation of B cell activation GO:0050869 9 6 1,000 8,701E-04 0,01205496 ! male meiosis GO:0007140 7 6 1,000 8,701E-04 0,01198278 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 8,701E-04 0,01191145 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 8,701E-04 0,01184097 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 8,701E-04 0,01177132 ! mRNA stabilization GO:0048255 15 6 1,000 8,701E-04 0,01170248 GO:0043489|RNA stabilization, ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 1,000 8,701E-04 0,01163444 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 8,701E-04 0,01156719 ! male sex determination GO:0030238 9 6 1,000 8,701E-04 0,01150071 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 8,701E-04 0,01143499 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! deoxyribonucleoside metabolic process GO:0009120 7 6 1,000 8,701E-04 0,01137002 ! gas homeostasis GO:0033483 11 6 1,000 8,701E-04 0,01130578 ! male gonad development GO:0008584 33 25 2,000 9,146E-04 0,01181817 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 9,146E-04 0,01175215 ! developmental maturation GO:0021700 75 57 3,000 9,786E-04 0,01250374 ! gonad development GO:0008406 79 57 3,000 9,786E-04 0,01243466 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,028E-03 0,0129926 ! response to ionizing radiation GO:0010212 47 27 2,000 1,15E-03 0,01445511 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,15E-03 0,01437655 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 1,15E-03 0,01429884 GO:0043433|negative regulation of transcription factor activity, ! regulation of homeostatic process GO:0032844 105 60 3,000 1,187E-03 0,01467375 ! neutral lipid catabolic process GO:0046461 9 7 1,000 1,212E-03 0,01490586 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,212E-03 0,01482658 ! glycerolipid catabolic process GO:0046503 9 7 1,000 1,212E-03 0,01474813 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,212E-03 0,01467051 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,212E-03 0,0145937 ! vesicle fusion GO:0006906 15 7 1,000 1,212E-03 0,01451769 ! organ growth GO:0035265 11 7 1,000 1,212E-03 0,01444247 ! behavioral fear response GO:0001662 13 7 1,000 1,212E-03 0,01436802 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,212E-03 0,01429434 ! protein heterooligomerization GO:0051291 10 7 1,000 1,212E-03 0,01422141 ! response to UV-B GO:0010224 11 7 1,000 1,212E-03 0,01414922 ! B cell lineage commitment GO:0002326 17 7 1,000 1,212E-03 0,01407776 ! T cell lineage commitment GO:0002360 12 7 1,000 1,212E-03 0,01400702 ! neuroblast proliferation GO:0007405 13 7 1,000 1,212E-03 0,01393698 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,212E-03 0,01386764 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,212E-03 0,01379899 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,212E-03 0,01373102 ! homeostasis of number of cells GO:0048872 84 61 3,000 1,262E-03 0,01423307 ! response to organic cyclic substance GO:0014070 47 28 2,000 1,281E-03 0,0143711 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 1,281E-03 0,01430134 ! regulation of B cell activation GO:0050864 42 28 2,000 1,281E-03 0,01423225 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,421E-03 0,0157094 ! tissue homeostasis GO:0001894 42 29 2,000 1,421E-03 0,01563423 GO:0048871|multicellular organismal homeostasis, ! regulation of transcription factor activity GO:0051090 97 63 3,000 1,424E-03 0,01559561 GO:0090046|regulation of transcription regulator activity, ! cell cycle checkpoint GO:0000075 108 64 3,000 1,51E-03 0,01645847 ! appendage morphogenesis GO:0035107 93 64 3,000 1,51E-03 0,01638083 GO:0035108|limb morphogenesis, ! negative regulation of cell activation GO:0050866 44 30 2,000 1,57E-03 0,01694946 ! response to heat GO:0009408 41 30 2,000 1,57E-03 0,01687026 ! reproductive structure development GO:0048608 90 65 3,000 1,599E-03 0,01710956 ! appendage development GO:0048736 94 65 3,000 1,599E-03 0,01703035 GO:0060173|limb development, ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,608E-03 0,01704024 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,608E-03 0,01696208 ! Golgi to endosome transport GO:0006895 16 8 1,000 1,608E-03 0,01688462 ! induction of positive chemotaxis GO:0050930 14 8 1,000 1,608E-03 0,01680788 ! melanin metabolic process GO:0006582 12 8 1,000 1,608E-03 0,01673182 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,608E-03 0,01665645 ! multicellular organism growth GO:0035264 14 8 1,000 1,608E-03 0,01658176 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,608E-03 0,01650774 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,608E-03 0,01643437 GO:0045685|regulation of glial cell differentiation, ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,608E-03 0,01636165 ! regulation of embryonic development GO:0045995 16 8 1,000 1,608E-03 0,01628957 ! mammary gland development GO:0030879 57 31 2,000 1,728E-03 0,01743253 ! maintenance of protein location in cell GO:0032507 60 31 2,000 1,728E-03 0,0173564 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 1,728E-03 0,01728094 ! metanephros development GO:0001656 58 31 2,000 1,728E-03 0,01720613 ! regulation of neuron differentiation GO:0045664 107 67 3,000 1,789E-03 0,01773868 ! development of primary sexual characteristics GO:0045137 92 68 3,000 1,89E-03 0,01865547 ! regulation of muscle development GO:0048634 48 32 2,000 1,896E-03 0,01863752 ! regulation of developmental growth GO:0048638 13 9 1,000 2,057E-03 0,0201285 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 2,057E-03 0,02004321 ! lung alveolus development GO:0048286 17 9 1,000 2,057E-03 0,01995864 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 2,057E-03 0,01987478 ! T cell selection GO:0045058 18 9 1,000 2,057E-03 0,01979163 ! receptor clustering GO:0043113 15 9 1,000 2,057E-03 0,01970916 ! motor axon guidance GO:0008045 14 9 1,000 2,057E-03 0,01962738 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 2,057E-03 0,01954628 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,057E-03 0,01946584 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,057E-03 0,01938606 ! thymus development GO:0048538 15 9 1,000 2,057E-03 0,01930693 ! spleen development GO:0048536 15 9 1,000 2,057E-03 0,01922845 ! blastocyst formation GO:0001825 12 9 1,000 2,057E-03 0,0191506 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 1,000 2,057E-03 0,01907338 ! response to nicotine GO:0035094 16 9 1,000 2,057E-03 0,01899678 ! localization within membrane GO:0051668 15 9 1,000 2,057E-03 0,01892079 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 2,074E-03 0,01900556 ! carbohydrate homeostasis GO:0033500 39 33 2,000 2,074E-03 0,01893014 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 2,000 2,074E-03 0,01885532 ! female gonad development GO:0008585 49 33 2,000 2,074E-03 0,01878109 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 2,074E-03 0,01870743 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 2,215E-03 0,01990078 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 2,262E-03 0,02024404 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 2,262E-03 0,02016557 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 2,262E-03 0,02008771 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 2,000 2,262E-03 0,02001045 ! female gamete generation GO:0007292 43 34 2,000 2,262E-03 0,01993378 ! negative regulation of transport GO:0051051 116 73 3,000 2,452E-03 0,02152578 ! tube morphogenesis GO:0035239 118 73 3,000 2,452E-03 0,02144394 ! response to steroid hormone stimulus GO:0048545 114 73 3,000 2,452E-03 0,02136271 ! maintenance of protein location GO:0045185 65 35 2,000 2,46E-03 0,02135315 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,558E-03 0,0221161 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 2,558E-03 0,02203326 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,558E-03 0,02195105 ! hippocampus development GO:0021766 19 10 1,000 2,558E-03 0,02186945 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,558E-03 0,02178845 ! blood vessel remodeling GO:0001974 21 10 1,000 2,558E-03 0,02170805 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,558E-03 0,02162824 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,558E-03 0,02154902 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,558E-03 0,02147037 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,558E-03 0,0213923 ! glucan biosynthetic process GO:0009250 13 10 1,000 2,558E-03 0,02131479 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 2,558E-03 0,02123784 ! B cell proliferation GO:0042100 14 10 1,000 2,558E-03 0,02116144 ! fear response GO:0042596 16 10 1,000 2,558E-03 0,0210856 ! negative regulation of ossification GO:0030279 19 10 1,000 2,558E-03 0,02101029 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 2,558E-03 0,02093552 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,558E-03 0,02086128 ! regulation of bone resorption GO:0045124 24 10 1,000 2,558E-03 0,02078757 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,558E-03 0,02071437 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 1,000 2,558E-03 0,02064169 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,558E-03 0,02056952 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 2,577E-03 0,02065092 ! tissue remodeling GO:0048771 62 36 2,000 2,669E-03 0,02131396 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 2,669E-03 0,02124021 GO:0046660|female sex differentiation, ! regulation of ligase activity GO:0051340 114 75 3,000 2,706E-03 0,0214612 ! regulation of protein transport GO:0051223 114 76 3,000 2,839E-03 0,02244237 GO:0070201|regulation of establishment of protein localization, ! sex differentiation GO:0007548 105 77 3,000 2,977E-03 0,02345178 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 3,11E-03 0,02441601 ! virus-host interaction GO:0019048 17 11 1,000 3,11E-03 0,02433296 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 3,11E-03 0,02425048 GO:0000725|recombinational repair, ! regulation of positive chemotaxis GO:0050926 17 11 1,000 3,11E-03 0,02416855 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 3,11E-03 0,02408717 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,11E-03 0,02400634 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 1,000 3,11E-03 0,02392606 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 3,11E-03 0,0238463 ! focal adhesion formation GO:0048041 24 11 1,000 3,11E-03 0,02376708 ! mitotic spindle organization GO:0007052 15 11 1,000 3,11E-03 0,02368838 ! adult heart development GO:0007512 11 11 1,000 3,11E-03 0,0236102 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 3,11E-03 0,02353253 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 3,11E-03 0,02345538 ! regulation of leukocyte migration GO:0002685 24 11 1,000 3,11E-03 0,02337873 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,11E-03 0,02330258 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of T cell proliferation GO:0042129 58 38 2,000 3,118E-03 0,02328453 ! mesenchymal cell development GO:0014031 64 38 2,000 3,118E-03 0,02320918 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 2,000 3,118E-03 0,02313431 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 3,359E-03 0,02484179 ! male sex differentiation GO:0046661 53 39 2,000 3,359E-03 0,02476217 ! forebrain development GO:0030900 131 80 3,000 3,418E-03 0,02511947 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 3,611E-03 0,02645061 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 3,611E-03 0,02636664 ! T cell differentiation GO:0030217 65 40 2,000 3,611E-03 0,02628321 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 3,714E-03 0,02694435 ! heart looping GO:0001947 15 12 1,000 3,714E-03 0,02685961 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 3,714E-03 0,02677542 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 1,000 3,714E-03 0,02669174 ! histone acetylation GO:0016573 23 12 1,000 3,714E-03 0,02660859 ! gland morphogenesis GO:0022612 23 12 1,000 3,714E-03 0,02652595 ! peptidyl-lysine modification GO:0018205 18 12 1,000 3,714E-03 0,02644383 ! regulation of mRNA stability GO:0043488 27 12 1,000 3,714E-03 0,02636221 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 3,714E-03 0,0262811 ! glucose transport GO:0015758 52 41 2,000 3,874E-03 0,0273346 ! regulation of T cell differentiation GO:0045580 59 41 2,000 3,874E-03 0,02725101 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 4,073E-03 0,02856043 ! mitochondrial transport GO:0006839 60 42 2,000 4,149E-03 0,02900579 ! cellular component disassembly GO:0022411 64 42 2,000 4,149E-03 0,0289179 ! hexose transport GO:0008645 54 42 2,000 4,149E-03 0,02883053 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 2,000 4,149E-03 0,02874369 ! regulation of cell shape GO:0008360 78 42 2,000 4,149E-03 0,02865737 ! regulation of membrane potential GO:0042391 128 85 3,000 4,249E-03 0,02925904 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 4,367E-03 0,0299804 ! regulation of chemokine production GO:0032642 17 13 1,000 4,367E-03 0,02989117 ! organelle fusion GO:0048284 28 13 1,000 4,367E-03 0,02980248 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 4,367E-03 0,0297143 ! bone mineralization GO:0030282 15 13 1,000 4,367E-03 0,02962665 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 4,367E-03 0,02953951 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,367E-03 0,02945289 ! cellular pigmentation GO:0033059 24 13 1,000 4,367E-03 0,02936677 ! regulation of RNA stability GO:0043487 28 13 1,000 4,367E-03 0,02928115 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 1,000 4,367E-03 0,02919603 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 4,435E-03 0,02956899 ! vesicle organization GO:0016050 79 43 2,000 4,435E-03 0,02948353 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 4,435E-03 0,02939856 ! skeletal muscle tissue development GO:0007519 123 87 3,000 4,616E-03 0,03050865 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 3,000 4,616E-03 0,03042123 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,733E-03 0,03110453 ! anatomical structure homeostasis GO:0060249 136 88 3,000 4,807E-03 0,03150172 ! regulation of neurogenesis GO:0050767 153 89 3,000 5,004E-03 0,03269688 ! cell maturation GO:0048469 60 45 2,000 5,043E-03 0,03285855 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 5,069E-03 0,03293304 ! neuron maturation GO:0042551 21 14 1,000 5,069E-03 0,03284027 ! regulation of S phase GO:0033261 18 14 1,000 5,069E-03 0,03274802 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,069E-03 0,03265629 ! limbic system development GO:0021761 25 14 1,000 5,069E-03 0,03256507 ! activation of MAPKK activity GO:0000186 21 14 1,000 5,069E-03 0,03247436 ! epidermis morphogenesis GO:0048730 29 14 1,000 5,069E-03 0,03238415 ! pituitary gland development GO:0021983 23 14 1,000 5,069E-03 0,03229445 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 5,069E-03 0,03220524 GO:0060675|ureteric bud morphogenesis, ! G1/S transition checkpoint GO:0031575 33 14 1,000 5,069E-03 0,03211652 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 5,069E-03 0,03202828 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 5,069E-03 0,03194054 ! muscle maintenance GO:0046716 19 14 1,000 5,069E-03 0,03185327 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 5,069E-03 0,03176647 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,069E-03 0,03168015 ! response to estrogen stimulus GO:0043627 74 47 2,000 5,699E-03 0,03551979 ! negative regulation of immune system process GO:0002683 73 47 2,000 5,699E-03 0,03542379 ! metencephalon development GO:0022037 19 15 1,000 5,819E-03 0,03607584 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,819E-03 0,03597886 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 5,819E-03 0,0358824 ! lipid phosphorylation GO:0046834 23 15 1,000 5,819E-03 0,03578646 ! myoblast differentiation GO:0045445 27 15 1,000 5,819E-03 0,03569103 ! centrosome cycle GO:0007098 16 15 1,000 5,819E-03 0,03559611 ! positive regulation of proteolysis GO:0045862 19 15 1,000 5,819E-03 0,03550169 ! neuron recognition GO:0008038 22 15 1,000 5,819E-03 0,03540777 ! biomineral formation GO:0031214 18 15 1,000 5,819E-03 0,03531434 ! response to temperature stimulus GO:0009266 62 48 2,000 6,045E-03 0,03658582 ! heart morphogenesis GO:0003007 65 48 2,000 6,045E-03 0,03648979 ! regulation of DNA replication GO:0006275 75 48 2,000 6,045E-03 0,03639427 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 6,045E-03 0,03629925 ! response to oxidative stress GO:0006979 141 94 3,000 6,068E-03 0,03634622 ! regulation of angiogenesis GO:0045765 94 49 2,000 6,403E-03 0,03825125 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 6,403E-03 0,03815216 ! cartilage development GO:0051216 70 49 2,000 6,403E-03 0,03805357 ! maintenance of location GO:0051235 84 49 2,000 6,403E-03 0,03795549 ! in utero embryonic development GO:0001701 147 96 3,000 6,533E-03 0,0386267 ! protein amino acid acetylation GO:0006473 28 16 1,000 6,617E-03 0,03902351 ! patterning of blood vessels GO:0001569 24 16 1,000 6,617E-03 0,03892371 ! regulation of protein binding GO:0043393 27 16 1,000 6,617E-03 0,03882441 ! protein export from nucleus GO:0006611 24 16 1,000 6,617E-03 0,03872562 ! ribosomal small subunit biogenesis GO:0042274 18 16 1,000 6,617E-03 0,03862734 ! diencephalon development GO:0021536 25 16 1,000 6,617E-03 0,03852954 ! neural crest cell migration GO:0001755 24 16 1,000 6,617E-03 0,03843225 ! negative regulation of translation GO:0017148 22 16 1,000 6,617E-03 0,03833544 ! skeletal muscle fiber development GO:0048741 73 50 2,000 6,774E-03 0,03914426 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 6,774E-03 0,03904616 ! muscle fiber development GO:0048747 74 51 2,000 7,157E-03 0,04115226 ! negative regulation of cell motion GO:0051271 104 51 2,000 7,157E-03 0,04104963 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 1,000 7,462E-03 0,04269064 GO:0019692|deoxyribose phosphate metabolic process, ! signal complex assembly GO:0007172 29 17 1,000 7,462E-03 0,0425847 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 7,462E-03 0,0424793 ! forelimb morphogenesis GO:0035136 19 17 1,000 7,462E-03 0,04237441 ! regulation of viral genome replication GO:0045069 24 17 1,000 7,462E-03 0,04227004 ! cell-substrate junction assembly GO:0007044 39 17 1,000 7,462E-03 0,04216618 ! neuromuscular junction development GO:0007528 23 17 1,000 7,462E-03 0,04206283 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,462E-03 0,04195999 ! nucleotide-excision repair GO:0006289 64 52 2,000 7,553E-03 0,04236932 ! regulation of bone remodeling GO:0046850 90 53 2,000 7,961E-03 0,04455277 ! kidney development GO:0001822 90 53 2,000 7,961E-03 0,04444463 ! positive regulation of DNA replication GO:0045740 29 18 1,000 8,352E-03 0,0465128 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 8,352E-03 0,04640045 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 8,352E-03 0,04628865 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 8,352E-03 0,04617737 ! axis specification GO:0009798 26 18 1,000 8,352E-03 0,04606664 ! somitogenesis GO:0001756 24 18 1,000 8,352E-03 0,04595643 ! cellular response to nutrient levels GO:0031669 27 18 1,000 8,352E-03 0,04584675 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 8,352E-03 0,04573759 ! activation of JUN kinase activity GO:0007257 23 18 1,000 8,352E-03 0,04562895 ! gut development GO:0048565 26 18 1,000 8,352E-03 0,04552082 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 8,352E-03 0,04541321 ! regulation of mitosis GO:0007088 84 54 2,000 8,383E-03 0,04547267 GO:0051783|regulation of nuclear division, ! regulation of tissue remodeling GO:0034103 91 54 2,000 8,383E-03 0,04536568 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 9,288E-03 0,05014531 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 9,288E-03 0,05002788 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 9,288E-03 0,04991099 ! regeneration GO:0031099 32 19 1,000 9,288E-03 0,04979465 ! response to alkaloid GO:0043279 32 19 1,000 9,288E-03 0,04967885 ! D-ribose metabolic process GO:0006014 25 19 1,000 9,288E-03 0,04956358 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 9,288E-03 0,04944885 ! renal system process GO:0003014 35 19 1,000 9,288E-03 0,04933465 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 9,288E-03 0,04922098 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 9,288E-03 0,04910783 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 1,000 9,288E-03 0,04899519 ! protein stabilization GO:0050821 26 19 1,000 9,288E-03 0,04888308 ! carbohydrate transport GO:0008643 74 57 2,000 9,725E-03 0,05106565 ! multicellular organism reproduction GO:0032504 83 57 2,000 9,725E-03 0,05094933 GO:0048609|reproductive process in a multicellular organism, ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 0,01019812 0,05330837 ! response to ethanol GO:0045471 37 20 1,000 0,01026795 0,05355166 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01026795 0,0534305 ! pallium development GO:0021543 38 20 1,000 0,01026795 0,05330989 ! positive regulation of locomotion GO:0040017 35 20 1,000 0,01026795 0,05318982 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 1,000 0,01026795 0,05307029 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01026795 0,0529513 ! actin filament-based movement GO:0030048 34 20 1,000 0,01026795 0,05283284 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 0,01068477 0,05485482 ! activation of MAPK activity GO:0000187 84 59 2,000 0,01068477 0,05473265 ! lung development GO:0030324 94 59 2,000 0,01068477 0,05461102 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,01118467 0,05703931 GO:0035113|embryonic appendage morphogenesis, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 0,01129184 0,05745849 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01129184 0,05733165 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01129184 0,05720536 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01129184 0,05707964 ! ovarian follicle development GO:0001541 30 21 1,000 0,01129184 0,05695446 ! deoxyribonucleotide metabolic process GO:0009262 27 21 1,000 0,01129184 0,05682984 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01129184 0,05670575 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 1,000 0,01129184 0,05658221 ! urogenital system development GO:0001655 101 61 2,000 0,01169789 0,05848943 ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01169789 0,05836255 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! respiratory tube development GO:0030323 99 62 2,000 0,01222448 0,06085781 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01235874 0,06139331 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01235874 0,061261 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01235874 0,06112925 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01235874 0,06099807 ! ureteric bud development GO:0001657 32 22 1,000 0,01235874 0,06086746 ! regulation of behavior GO:0050795 38 22 1,000 0,01235874 0,0607374 ! neural tube closure GO:0001843 33 22 1,000 0,01235874 0,0606079 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01235874 0,06047894 ! protein tetramerization GO:0051262 39 22 1,000 0,01235874 0,06035054 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01276451 0,06219994 ! respiratory system development GO:0060541 100 64 2,000 0,01331802 0,06475991 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01346793 0,06535071 ! myelination GO:0042552 35 23 1,000 0,01346793 0,06521313 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01346793 0,06507613 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,01346793 0,0649397 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01346793 0,06480385 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01346793 0,06466856 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01346793 0,06453383 ! interaction with host GO:0051701 37 23 1,000 0,01346793 0,06439966 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01346793 0,06426606 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01346793 0,064133 ! pentose metabolic process GO:0019321 31 23 1,000 0,01346793 0,06400049 ! spermatid development GO:0007286 33 23 1,000 0,01346793 0,06386853 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01346793 0,06373712 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01388505 0,06557619 ! receptor metabolic process GO:0043112 37 24 1,000 0,0146187 0,06889963 ! neural crest cell development GO:0014032 39 24 1,000 0,0146187 0,06875873 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,0146187 0,0686184 ! primary neural tube formation GO:0014020 35 24 1,000 0,0146187 0,06847865 ! negative regulation of cell development GO:0010721 56 24 1,000 0,0146187 0,06833947 GO:0050768|negative regulation of neurogenesis, ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,0146187 0,06820085 ! learning or memory GO:0007611 123 68 2,000 0,01566769 0,07294675 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,01581036 0,07346229 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01581036 0,07331418 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01581036 0,07316667 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01581036 0,07301975 GO:0032943|mononuclear cell proliferation, ! response to drug GO:0042493 108 69 2,000 0,01628921 0,07508053 ! response to metal ion GO:0010038 103 70 2,000 0,01692443 0,07785237 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 2,000 0,01692443 0,07769698 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01704222 0,07808187 ! translational initiation GO:0006413 43 26 1,000 0,01704222 0,07792664 ! post-embryonic development GO:0009791 42 26 1,000 0,01704222 0,07777202 ! spermatid differentiation GO:0048515 36 26 1,000 0,01704222 0,07761802 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,01757337 0,07987896 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01831358 0,08307938 ! cell junction assembly GO:0034329 56 28 1,000 0,01962379 0,08884787 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,01962379 0,08867332 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 0,01962379 0,08849945 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01962379 0,08832626 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01962379 0,08815375 ! response to inorganic substance GO:0010035 115 75 2,000 0,02030679 0,09104409 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02097217 0,09384434 ! ovulation cycle process GO:0022602 41 29 1,000 0,02097217 0,09366212 ! telencephalon development GO:0021537 52 29 1,000 0,02097217 0,0934806 ! regulation of cell morphogenesis GO:0022604 140 76 2,000 0,02102463 0,09353315 ! protein ubiquitination GO:0016567 125 77 2,000 0,02175627 0,09660121 ! collagen metabolic process GO:0032963 40 30 1,000 0,02235806 0,09908197 ! spindle organization GO:0007051 37 30 1,000 0,02235806 0,09889143 ! ovulation cycle GO:0042698 43 30 1,000 0,02235806 0,09870162 ! hindbrain development GO:0030902 45 30 1,000 0,02235806 0,09851254 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02235806 0,09832418 ! T cell activation GO:0042110 134 79 2,000 0,02326101 0,10209984 ! glial cell differentiation GO:0010001 55 31 1,000 0,02378082 0,10418264 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,02378082 0,10398457 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 1,000 0,02378082 0,10378726 ! segmentation GO:0035282 41 31 1,000 0,02378082 0,10359069 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02378082 0,10339487 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,0252398 0,10953119 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,0252398 0,10932492 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,0252398 0,10911942 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,0252398 0,10891469 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 1,000 0,0252398 0,10871073 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,0252398 0,10850753 ! cytokine production GO:0001816 44 32 1,000 0,0252398 0,10830509 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,0252398 0,10810341 ! ossification GO:0001503 134 82 2,000 0,02562169 0,10953509 GO:0060348|bone development, ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02673436 0,11407982 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 1,000 0,02673436 0,11386856 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02673436 0,11365808 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02673436 0,11344838 ! cell junction organization GO:0034330 63 33 1,000 0,02673436 0,11323945 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02673436 0,11303129 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02673436 0,1128239 ! lipid homeostasis GO:0055088 55 33 1,000 0,02673436 0,11261726 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02673436 0,11241138 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 1,000 0,02673436 0,11220625 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 0,02810647 0,11775025 ! Golgi vesicle transport GO:0048193 138 85 2,000 0,02810647 0,11753616 ! rRNA metabolic process GO:0016072 107 85 2,000 0,02810647 0,11732284 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 2,000 0,02810647 0,1171103 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,02810647 0,11689853 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,02826388 0,11734101 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 0,02826388 0,11712958 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,02826388 0,11691892 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02826388 0,11670901 ! neuron migration GO:0001764 46 34 1,000 0,02826388 0,11649985 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,02826388 0,11629144 ! embryonic organ development GO:0048568 45 34 1,000 0,02826388 0,11608378 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,02982773 0,12228839 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02982773 0,12207079 ! glycogen metabolic process GO:0005977 48 35 1,000 0,02982773 0,12185397 ! pigment metabolic process GO:0042440 61 35 1,000 0,02982773 0,12163792 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02982773 0,12142263 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03142531 0,12770003 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,03142531 0,12747481 ! organic ether metabolic process GO:0018904 46 36 1,000 0,03142531 0,12725039 ! neural tube development GO:0021915 50 36 1,000 0,03142531 0,12702675 ! glucan metabolic process GO:0044042 49 36 1,000 0,03142531 0,12680389 GO:0006073|cellular glucan metabolic process, ! regulation of T cell activation GO:0050863 128 89 2,000 0,03161186 0,12733324 ! leukocyte differentiation GO:0002521 143 90 2,000 0,03252241 0,13077192 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,03252241 0,1305437 ! learning GO:0007612 67 37 1,000 0,03305601 0,1324544 ! response to virus GO:0009615 122 91 2,000 0,03344658 0,13378633 ! cell fate commitment GO:0045165 141 92 2,000 0,03438435 0,13729863 ! gliogenesis GO:0042063 71 38 1,000 0,03471923 0,13839553 ! pigmentation GO:0043473 74 38 1,000 0,03471923 0,1381561 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03641437 0,14465122 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,03641437 0,14440182 ! chromatin remodeling GO:0006338 68 39 1,000 0,03641437 0,14415328 ! JNK cascade GO:0007254 54 39 1,000 0,03641437 0,1439056 ! synapse organization GO:0050808 55 39 1,000 0,03641437 0,14365876 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03802369 0,14975081 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03802369 0,14949483 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03802369 0,14923972 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03802369 0,14898548 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03802369 0,1487321 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03802369 0,14847959 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03802369 0,14822792 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03802369 0,14797712 ! sleep GO:0030431 11 5 0,000 0,03802369 0,14772715 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03802369 0,14747804 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03802369 0,14722976 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03802369 0,14698231 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03802369 0,1467357 ! tongue development GO:0043586 6 5 0,000 0,03802369 0,14648991 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03802369 0,14624494 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03802369 0,14600079 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03802369 0,14575746 ! cobalt ion transport GO:0006824 9 5 0,000 0,03802369 0,14551493 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03802369 0,14527322 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03802369 0,1450323 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03802369 0,14479218 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03802369 0,14455285 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03802369 0,14431432 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03802369 0,14407657 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03802369 0,1438396 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03802369 0,14360341 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03802369 0,14336799 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03802369 0,14313335 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03802369 0,14289947 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03802369 0,14266636 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03802369 0,142434 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03802369 0,1422024 ! malate metabolic process GO:0006108 7 5 0,000 0,03802369 0,14197155 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03802369 0,14174145 ! behavioral response to pain GO:0048266 7 5 0,000 0,03802369 0,1415121 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03802369 0,14128348 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03802369 0,14105561 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03802369 0,14082846 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03802369 0,14060205 ! mating behavior GO:0007617 6 5 0,000 0,03802369 0,14037637 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03802369 0,1401514 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03802369 0,13992716 ! rhythmic behavior GO:0007622 12 5 0,000 0,03802369 0,13970364 ! copulation GO:0007620 7 5 0,000 0,03802369 0,13948082 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03802369 0,13925872 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03802369 0,13903732 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03802369 0,13881663 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03802369 0,13859663 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03802369 0,13837733 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03802369 0,13815873 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03802369 0,13794081 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03802369 0,13772358 ! response to protozoan GO:0001562 9 5 0,000 0,03802369 0,13750704 ! lymph vessel development GO:0001945 7 5 0,000 0,03802369 0,13729117 ! endochondral ossification GO:0001958 12 5 0,000 0,03802369 0,13707598 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03802369 0,13686146 ! parathyroid gland development GO:0060017 8 5 0,000 0,03802369 0,13664762 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03802369 0,13643444 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03802369 0,13622192 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03802369 0,13601007 ! nuclear migration GO:0007097 10 5 0,000 0,03802369 0,13579888 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03802369 0,13558833 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03802369 0,13537845 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03802369 0,13516921 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03802369 0,13496061 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03802369 0,13475266 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03802369 0,13454535 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03802369 0,13433867 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03802369 0,13413263 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03802369 0,13392722 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03802369 0,13372244 ! ovulation GO:0030728 6 5 0,000 0,03802369 0,13351828 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03802369 0,13331475 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03802369 0,13311184 ! response to pH GO:0009268 9 5 0,000 0,03802369 0,13290954 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03802369 0,13270785 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03802369 0,13250678 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03802369 0,13230632 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03802369 0,13210646 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03802369 0,1319072 ! polyol catabolic process GO:0046174 7 5 0,000 0,03802369 0,13170855 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03802369 0,13151049 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03802369 0,13131303 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03802369 0,13111616 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03802369 0,13091987 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03802369 0,13072418 ! urea metabolic process GO:0019627 6 5 0,000 0,03802369 0,13052907 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03802369 0,13033454 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03802369 0,13014059 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03802369 0,12994721 ! neutrophil activation GO:0042119 5 5 0,000 0,03802369 0,12975441 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03802369 0,12956219 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03802369 0,12937053 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03802369 0,12917943 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03802369 0,1289889 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03802369 0,12879893 ! forebrain neuron development GO:0021884 7 5 0,000 0,03802369 0,12860952 ! melanosome organization GO:0032438 7 5 0,000 0,03802369 0,12842067 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03802369 0,12823237 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03802369 0,12804462 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03802369 0,12785742 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03802369 0,12767077 ! nucleoside transport GO:0015858 6 5 0,000 0,03802369 0,12748466 ! nucleoside salvage GO:0043174 7 5 0,000 0,03802369 0,12729909 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03802369 0,12711406 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03802369 0,12692957 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03802369 0,12674562 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03802369 0,12656219 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03802369 0,1263793 ! depyrimidination GO:0045008 8 5 0,000 0,03802369 0,12619693 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03802369 0,12601509 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03802369 0,12583378 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03802369 0,12565298 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03802369 0,12547271 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03802369 0,12529295 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03802369 0,1251137 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03802369 0,12493497 ! monocyte differentiation GO:0030224 8 5 0,000 0,03802369 0,12475674 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03802369 0,12457903 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03802369 0,12440181 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03802369 0,12422511 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03802369 0,1240489 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03802369 0,1238732 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03802369 0,12369799 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03802369 0,12352327 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03802369 0,12334905 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03802369 0,12317532 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03802369 0,12300208 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03802369 0,12282932 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03802369 0,12265705 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03802369 0,12248526 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03802369 0,12231395 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03802369 0,12214312 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03802369 0,12197277 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03802369 0,12180289 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03802369 0,12163348 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03802369 0,12146455 ! neural tube patterning GO:0021532 6 5 0,000 0,03802369 0,12129608 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03802369 0,12112808 ! histone demethylation GO:0016577 9 5 0,000 0,03802369 0,12096055 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03802369 0,12079347 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03802369 0,12062686 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03802369 0,12046071 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03802369 0,12029501 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03802369 0,12012977 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03802369 0,11996499 ! transcription termination GO:0006353 8 5 0,000 0,03802369 0,11980065 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03802369 0,11963677 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03802369 0,11947333 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03802369 0,11931034 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03802369 0,11914779 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03802369 0,11898568 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03802369 0,11882402 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03802369 0,11866279 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03802369 0,118502 ! apical protein localization GO:0045176 6 5 0,000 0,03802369 0,11834165 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03802369 0,11818172 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03802369 0,11802223 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03802369 0,11786317 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03802369 0,11770454 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03802369 0,11754634 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03802369 0,11738856 ! glial cell migration GO:0008347 10 5 0,000 0,03802369 0,1172312 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03802369 0,11707426 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03802369 0,11691775 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03802369 0,11676165 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03802369 0,11660597 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03802369 0,1164507 ! neural plate development GO:0001840 6 5 0,000 0,03802369 0,11629585 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03802369 0,1161414 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03802369 0,11598737 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03802369 0,11583374 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03802369 0,11568052 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03802369 0,11552771 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03802369 0,1153753 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03802369 0,11522329 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03802369 0,11507168 ! spindle assembly GO:0051225 5 5 0,000 0,03802369 0,11492047 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03802369 0,11476965 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03802369 0,11461923 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03802369 0,11446921 ! organ regeneration GO:0031100 7 5 0,000 0,03802369 0,11431958 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03802369 0,11417033 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03802369 0,11402148 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03802369 0,11387302 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03802369 0,11372494 GO:0055081|anion homeostasis, ! response to calcium ion GO:0051592 58 40 1,000 0,03814086 0,11392725 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,03814086 0,11377948 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03814086 0,1136321 ! ATP synthesis coupled electron transport GO:0042773 48 40 1,000 0,03814086 0,1134851 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 1,000 0,03814086 0,11333848 ! B cell differentiation GO:0030183 62 40 1,000 0,03814086 0,11319223 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03814086 0,11304637 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03814086 0,11290088 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,0382707 0,11313961 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,0382707 0,11299437 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03989812 0,11764829 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,03989812 0,11749766 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03989812 0,1173474 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,03989812 0,11719753 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,04168557 0,12229185 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,04168557 0,12213606 ! regulation of translation GO:0006417 151 100 2,000 0,04237161 0,12398816 ! positive regulation of binding GO:0051099 59 43 1,000 0,04350265 0,12713609 ! activation of caspase activity GO:0006919 65 43 1,000 0,04350265 0,12697475 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04350265 0,12681381 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,04534881 0,13202819 ! regulation of action potential GO:0001508 71 44 1,000 0,04534881 0,13186127 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,04534881 0,13169478 ! tRNA transcription GO:0009304 11 6 0,000 0,04545441 0,13183499 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04545441 0,13166895 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04545441 0,13150333 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04545441 0,13133812 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04545441 0,13117333 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04545441 0,13100895 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04545441 0,13084499 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04545441 0,13068143 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04545441 0,13051828 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04545441 0,13035554 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04545441 0,13019321 ! prostate gland development GO:0030850 9 6 0,000 0,04545441 0,13003128 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04545441 0,12986975 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04545441 0,12970862 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04545441 0,12954789 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04545441 0,12938756 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04545441 0,12922762 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04545441 0,12906808 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04545441 0,12890893 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,04545441 0,12875018 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04545441 0,12859182 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04545441 0,12843384 ! signal peptide processing GO:0006465 8 6 0,000 0,04545441 0,12827625 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04545441 0,12811905 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04545441 0,12796224 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04545441 0,1278058 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04545441 0,12764975 ! opsonization GO:0008228 8 6 0,000 0,04545441 0,12749408 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04545441 0,12733879 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04545441 0,12718388 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04545441 0,12702934 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04545441 0,12687518 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04545441 0,12672139 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04545441 0,12656797 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04545441 0,12641493 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04545441 0,12626225 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04545441 0,12610995 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04545441 0,12595801 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04545441 0,12580643 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04545441 0,12565522 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04545441 0,12550438 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04545441 0,12535389 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04545441 0,12520377 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04545441 0,125054 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04545441 0,1249046 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04545441 0,12475554 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04545441 0,12460685 ! thymic T cell selection GO:0045061 12 6 0,000 0,04545441 0,12445851 ! protein lipoylation GO:0009249 10 6 0,000 0,04545441 0,12431052 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04545441 0,12416288 ! drug transport GO:0015893 6 6 0,000 0,04545441 0,12401559 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04545441 0,12386866 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04545441 0,12372207 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04545441 0,12357582 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04545441 0,12342992 ! histidine metabolic process GO:0006547 6 6 0,000 0,04545441 0,12328437 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04545441 0,12313916 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04545441 0,12299429 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04545441 0,12284976 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04545441 0,12270557 ! adenohypophysis development GO:0021984 10 6 0,000 0,04545441 0,12256172 ! hyperosmotic response GO:0006972 8 6 0,000 0,04545441 0,1224182 ! microtubule nucleation GO:0007020 10 6 0,000 0,04545441 0,12227502 ! ER overload response GO:0006983 7 6 0,000 0,04545441 0,12213218 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04545441 0,12198967 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04545441 0,12184749 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04545441 0,12170564 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04545441 0,12156412 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04545441 0,12142293 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04545441 0,12128207 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04545441 0,12114154 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04545441 0,12100133 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04545441 0,12086144 ! purine salvage GO:0043101 8 6 0,000 0,04545441 0,12072188 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04545441 0,12058264 ! organic alcohol transport GO:0015850 9 6 0,000 0,04545441 0,12044372 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04545441 0,12030512 ! carnitine transport GO:0015879 8 6 0,000 0,04545441 0,12016683 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04545441 0,12002887 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04545441 0,11989122 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04545441 0,11975389 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04545441 0,11961687 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04545441 0,11948017 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04545441 0,11934377 ! parturition GO:0007567 12 6 0,000 0,04545441 0,11920769 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04545441 0,11907192 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04545441 0,11893646 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04545441 0,1188013 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04545441 0,11866645 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04545441 0,11853191 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04545441 0,11839767 ! macrophage differentiation GO:0030225 10 6 0,000 0,04545441 0,11826374 ! astrocyte development GO:0014002 14 6 0,000 0,04545441 0,11813011 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04545441 0,11799678 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04545441 0,11786375 ! interaction with symbiont GO:0051702 8 6 0,000 0,04545441 0,11773102 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04545441 0,11759859 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04545441 0,11746646 ! eating behavior GO:0042755 6 6 0,000 0,04545441 0,11733462 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04545441 0,11720308 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04545441 0,11707183 ! response to copper ion GO:0046688 9 6 0,000 0,04545441 0,11694088 ! DNA topological change GO:0006265 8 6 0,000 0,04545441 0,11681022 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04545441 0,11667985 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04545441 0,11654977 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04545441 0,11641998 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04545441 0,11629049 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04545441 0,11616127 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04545441 0,11603235 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04545441 0,11590371 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04545441 0,11577536 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04545441 0,11564729 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04545441 0,1155195 ! Schwann cell development GO:0014044 14 6 0,000 0,04545441 0,11539199 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04545441 0,11526477 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04545441 0,11513783 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04545441 0,11501116 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04545441 0,11488478 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04545441 0,11475867 ! histone ubiquitination GO:0016574 7 6 0,000 0,04545441 0,11463284 ! regulation of meiosis GO:0040020 10 6 0,000 0,04545441 0,11450728 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04545441 0,114382 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04545441 0,11425699 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04545441 0,11413226 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04545441 0,11400779 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04545441 0,1138836 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04545441 0,11375968 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04545441 0,11363603 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04545441 0,11351264 ! receptor internalization GO:0031623 9 6 0,000 0,04545441 0,11338953 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04545441 0,11326668 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04545441 0,1131441 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04545441 0,11302178 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04545441 0,11289973 ! protein deubiquitination GO:0016579 8 6 0,000 0,04545441 0,11277794 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04545441 0,11265641 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04545441 0,11253514 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04545441 0,11241414 ! axonal fasciculation GO:0007413 9 6 0,000 0,04545441 0,11229339 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04545441 0,1121729 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04545441 0,11205268 ! midbrain development GO:0030901 6 6 0,000 0,04545441 0,1119327 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04545441 0,11181299 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04545441 0,11169353 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04545441 0,11157433 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04545441 0,11145538 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04545441 0,11133668 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04545441 0,11121824 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04545441 0,11110005 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04545441 0,11098211 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04545441 0,11086442 ! adult feeding behavior GO:0008343 6 6 0,000 0,04545441 0,11074698 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04545441 0,11062978 ! pigment granule transport GO:0051904 12 6 0,000 0,04545441 0,11051284 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04545441 0,11039614 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04545441 0,11027969 ! catecholamine transport GO:0051937 7 6 0,000 0,04545441 0,11016348 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04545441 0,11004752 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04545441 0,1099318 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04545441 0,10981633 ! protein prenylation GO:0018342 10 6 0,000 0,04545441 0,1097011 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04545441 0,10958611 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04545441 0,10947136 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04545441 0,10935685 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04545441 0,10924258 ! positive regulation of defense response GO:0031349 59 45 1,000 0,0472235 0,11337583 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,0472235 0,11325761 ! cell recognition GO:0008037 58 45 1,000 0,0472235 0,11313963 ! regulation of ossification GO:0030278 71 46 1,000 0,04912617 0,11757563 ! histone modification GO:0016570 68 46 1,000 0,04912617 0,11745341 ! respiratory electron transport chain GO:0022904 59 47 1,000 0,05105628 0,12194127 ! endocrine system development GO:0035270 83 47 1,000 0,05105628 0,12181477 ! covalent chromatin modification GO:0016569 75 47 1,000 0,05105628 0,12168854 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,05105628 0,12156257 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,05105628 0,12143686 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05282816 0,12552146 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05282816 0,12539192 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05282816 0,12526265 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05282816 0,12513365 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05282816 0,12500491 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05282816 0,12487643 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05282816 0,12474822 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05282816 0,12462028 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05282816 0,12449259 ! reproductive behavior GO:0019098 12 7 0,000 0,05282816 0,12436517 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05282816 0,12423801 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05282816 0,1241111 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05282816 0,12398446 ! oligopeptide transport GO:0006857 11 7 0,000 0,05282816 0,12385807 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05282816 0,12373195 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05282816 0,12360607 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05282816 0,12348046 ! RNA methylation GO:0001510 11 7 0,000 0,05282816 0,1233551 ! pericardium development GO:0060039 8 7 0,000 0,05282816 0,12322999 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05282816 0,12310514 ! fibril organization GO:0043206 13 7 0,000 0,05282816 0,12298054 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,05282816 0,12285619 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05282816 0,12273209 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,05282816 0,12260825 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05282816 0,12248465 ! lipoprotein transport GO:0042953 9 7 0,000 0,05282816 0,1223613 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05282816 0,1222382 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05282816 0,12211535 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05282816 0,12199274 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05282816 0,12187038 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05282816 0,12174827 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05282816 0,1216264 ! chemosensory behavior GO:0007635 9 7 0,000 0,05282816 0,12150477 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05282816 0,12138339 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05282816 0,12126225 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05282816 0,12114135 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05282816 0,12102069 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05282816 0,12090027 ! reflex GO:0060004 12 7 0,000 0,05282816 0,12078009 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05282816 0,12066015 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05282816 0,12054045 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05282816 0,12042098 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05282816 0,12030175 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05282816 0,12018276 ! spinal cord patterning GO:0021511 7 7 0,000 0,05282816 0,120064 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05282816 0,11994548 ! adrenal gland development GO:0030325 17 7 0,000 0,05282816 0,11982719 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05282816 0,11970913 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05282816 0,11959131 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05282816 0,11947372 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05282816 0,11935636 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05282816 0,11923923 ! endosome organization GO:0007032 10 7 0,000 0,05282816 0,11912232 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05282816 0,11900565 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05282816 0,11888921 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05282816 0,11877299 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05282816 0,118657 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05282816 0,11854124 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05282816 0,1184257 ! galactose metabolic process GO:0006012 10 7 0,000 0,05282816 0,11831039 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05282816 0,1181953 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05282816 0,11808044 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05282816 0,1179658 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05282816 0,11785138 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05282816 0,11773718 ! retinol metabolic process GO:0042572 9 7 0,000 0,05282816 0,11762321 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05282816 0,11750945 ! rRNA modification GO:0000154 12 7 0,000 0,05282816 0,11739591 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05282816 0,1172826 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,05282816 0,1171695 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05282816 0,11705662 ! intermediate filament organization GO:0045109 11 7 0,000 0,05282816 0,11694396 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05282816 0,11683151 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05282816 0,11671928 ! fibrinolysis GO:0042730 9 7 0,000 0,05282816 0,11660727 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05282816 0,11649547 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05282816 0,11638388 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05282816 0,11627251 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05282816 0,11616135 ! response to tropane GO:0014073 13 7 0,000 0,05282816 0,1160504 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05282816 0,11593967 ! melanosome localization GO:0032400 10 7 0,000 0,05282816 0,11582914 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05282816 0,11571883 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05282816 0,11560873 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05282816 0,11549883 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05282816 0,11538915 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05282816 0,11527967 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05282816 0,1151704 ! mast cell activation GO:0045576 9 7 0,000 0,05282816 0,11506134 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05282816 0,11495248 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05282816 0,11484383 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05282816 0,11473538 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05282816 0,11462714 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05282816 0,11451911 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05282816 0,11441127 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05282816 0,11430364 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05282816 0,11419621 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05282816 0,11408899 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05282816 0,11398196 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05282816 0,11387514 ! response to tumor cell GO:0002347 12 7 0,000 0,05282816 0,11376851 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05282816 0,11366209 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05282816 0,11355586 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05282816 0,11344983 ! diuresis GO:0030146 12 7 0,000 0,05282816 0,113344 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05282816 0,11323837 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05282816 0,11313293 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05282816 0,11302769 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05282816 0,11292265 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05282816 0,1128178 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05282816 0,11271315 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05282816 0,11260868 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05282816 0,11250442 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05282816 0,11240034 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05282816 0,11229646 ! lymph node development GO:0048535 9 7 0,000 0,05282816 0,11219277 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05282816 0,11208927 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05282816 0,11198596 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05282816 0,11188285 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05282816 0,11177992 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05282816 0,11167718 ! ATP catabolic process GO:0006200 10 7 0,000 0,05282816 0,11157463 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05282816 0,11147227 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05282816 0,11137009 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05282816 0,11126811 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05282816 0,1111663 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05282816 0,11106469 ! muscle adaptation GO:0043500 12 7 0,000 0,05282816 0,11096326 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05282816 0,11086202 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05282816 0,11076096 ! retina homeostasis GO:0001895 9 7 0,000 0,05282816 0,11066008 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05282816 0,11055939 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05282816 0,11045888 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05282816 0,11035856 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05282816 0,11025841 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05282816 0,11015845 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05282816 0,11005867 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05282816 0,10995907 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,05301331 0,11024467 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,05301331 0,11014508 ! nuclear export GO:0051168 69 48 1,000 0,05301331 0,11004567 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,05301331 0,10994645 ! RNA elongation GO:0006354 62 49 1,000 0,05499673 0,11395718 ! ear development GO:0043583 72 50 1,000 0,05700602 0,11801427 ! membrane fusion GO:0006944 80 50 1,000 0,05700602 0,11790814 ! lipid modification GO:0030258 73 50 1,000 0,05700602 0,1178022 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05904068 0,12189728 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06014537 0,12406668 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06014537 0,12395551 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,06014537 0,12384454 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06014537 0,12373376 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06014537 0,12362319 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06014537 0,12351281 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06014537 0,12340263 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06014537 0,12329265 ! phosphate transport GO:0006817 10 8 0,000 0,06014537 0,12318286 ! N-glycan processing GO:0006491 12 8 0,000 0,06014537 0,12307326 ! UTP metabolic process GO:0046051 8 8 0,000 0,06014537 0,12296386 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06014537 0,12285466 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06014537 0,12274565 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06014537 0,12263683 ! succinate metabolic process GO:0006105 14 8 0,000 0,06014537 0,12252821 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,06014537 0,12241978 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,06014537 0,12231154 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06014537 0,12220349 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,06014537 0,12209563 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06014537 0,12198796 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,06014537 0,12188048 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06014537 0,12177319 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06014537 0,12166609 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06014537 0,12155918 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06014537 0,12145246 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06014537 0,12134592 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06014537 0,12123957 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06014537 0,1211334 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06014537 0,12102743 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06014537 0,12092163 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06014537 0,12081602 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06014537 0,1207106 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06014537 0,12060536 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06014537 0,1205003 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06014537 0,12039543 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06014537 0,12029074 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06014537 0,12018623 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06014537 0,1200819 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06014537 0,11997775 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06014537 0,11987378 ! macrophage activation GO:0042116 12 8 0,000 0,06014537 0,11977 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06014537 0,11966639 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06014537 0,11956296 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06014537 0,11945971 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06014537 0,11935664 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06014537 0,11925375 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06014537 0,11915103 ! ruffle organization GO:0031529 11 8 0,000 0,06014537 0,11904849 ! osteoblast development GO:0002076 13 8 0,000 0,06014537 0,11894613 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06014537 0,11884394 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06014537 0,11874193 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06014537 0,11864009 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06014537 0,11853843 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06014537 0,11843694 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06014537 0,11833563 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06014537 0,11823449 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06014537 0,11813352 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06014537 0,11803272 ! brain morphogenesis GO:0048854 20 8 0,000 0,06014537 0,1179321 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06014537 0,11783164 ! segment specification GO:0007379 10 8 0,000 0,06014537 0,11773136 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,06014537 0,11763125 ! cellular extravasation GO:0045123 11 8 0,000 0,06014537 0,11753131 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06014537 0,11743153 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06014537 0,11733193 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06014537 0,1172325 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06014537 0,11713323 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06014537 0,11703414 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,06014537 0,11693521 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06014537 0,11683644 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06014537 0,11673785 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06014537 0,11663942 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06014537 0,11654115 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06014537 0,11644305 ! icosanoid secretion GO:0032309 12 8 0,000 0,06014537 0,11634512 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06014537 0,11624735 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06014537 0,11614975 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06014537 0,11605231 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06014537 0,11595503 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06014537 0,11585791 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06014537 0,11576096 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06014537 0,11566417 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06014537 0,11556754 ! sterol catabolic process GO:0016127 9 8 0,000 0,06014537 0,11547107 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06014537 0,11537477 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06014537 0,11527862 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06014537 0,11518264 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06014537 0,11508681 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06014537 0,11499115 ! prophase GO:0051324 11 8 0,000 0,06014537 0,11489564 ! S phase GO:0051320 8 8 0,000 0,06014537 0,11480029 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06014537 0,1147051 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,06014537 0,11461006 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06014537 0,11451519 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06014537 0,11442047 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06014537 0,11432591 ! hormone catabolic process GO:0042447 13 8 0,000 0,06014537 0,1142315 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06014537 0,11413725 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06014537 0,11404316 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06014537 0,11394922 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06014537 0,11385543 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06014537 0,1137618 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,06014537 0,11366832 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06014537 0,113575 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06014537 0,11348183 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06014537 0,11338881 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06014537 0,11329594 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06014537 0,11320323 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06014537 0,11311067 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06014537 0,11301826 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06014537 0,112926 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,0611002 0,11462516 ! single fertilization GO:0007338 59 53 1,000 0,06318407 0,11843795 ! cell projection assembly GO:0030031 76 53 1,000 0,06318407 0,1183415 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,06529181 0,12218972 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,06529181 0,12209038 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06740646 0,12594221 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06740646 0,12583999 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06740646 0,12573793 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06740646 0,12563603 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06740646 0,1255343 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06740646 0,12543274 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06740646 0,12533134 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06740646 0,1252301 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06740646 0,12512903 ! GTP metabolic process GO:0046039 9 9 0,000 0,06740646 0,12502812 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06740646 0,12492737 ! social behavior GO:0035176 14 9 0,000 0,06740646 0,12482678 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06740646 0,12472636 ! artery development GO:0060840 19 9 0,000 0,06740646 0,1246261 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06740646 0,124526 ! response to pain GO:0048265 16 9 0,000 0,06740646 0,12442606 ! protein complex disassembly GO:0043241 17 9 0,000 0,06740646 0,12432628 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06740646 0,12422666 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06740646 0,12412719 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06740646 0,12402789 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06740646 0,12392875 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06740646 0,12382977 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06740646 0,12373094 ! protein targeting to ER GO:0045047 19 9 0,000 0,06740646 0,12363227 ! endoderm development GO:0007492 12 9 0,000 0,06740646 0,12353376 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06740646 0,1234354 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06740646 0,1233372 ! arginine catabolic process GO:0006527 10 9 0,000 0,06740646 0,12323916 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06740646 0,12314128 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06740646 0,12304354 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06740646 0,12294597 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06740646 0,12284855 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06740646 0,12275128 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06740646 0,12265417 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06740646 0,12255721 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06740646 0,1224604 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06740646 0,12236375 ! mannose metabolic process GO:0006013 9 9 0,000 0,06740646 0,12226724 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06740646 0,1221709 ! epithelial cell development GO:0002064 10 9 0,000 0,06740646 0,1220747 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06740646 0,12197865 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06740646 0,12188276 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06740646 0,12178701 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06740646 0,12169142 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06740646 0,12159597 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06740646 0,12150068 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06740646 0,12140553 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06740646 0,12131054 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06740646 0,12121569 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06740646 0,12112099 ! DNA ligation GO:0006266 14 9 0,000 0,06740646 0,12102644 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06740646 0,12093203 ! response to amine stimulus GO:0014075 13 9 0,000 0,06740646 0,12083778 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06740646 0,12074367 ! erythrocyte development GO:0048821 11 9 0,000 0,06740646 0,1206497 ! renal water homeostasis GO:0003091 14 9 0,000 0,06740646 0,12055588 ! postreplication repair GO:0006301 11 9 0,000 0,06740646 0,12046221 ! mRNA cleavage GO:0006379 13 9 0,000 0,06740646 0,12036869 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06740646 0,1202753 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06740646 0,12018207 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06740646 0,12008897 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06740646 0,11999603 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06740646 0,11990322 ! acid secretion GO:0046717 14 9 0,000 0,06740646 0,11981056 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06740646 0,11971804 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06740646 0,11962567 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06740646 0,11953344 ! purine base metabolic process GO:0006144 18 9 0,000 0,06740646 0,11944135 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06740646 0,1193494 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06740646 0,11925759 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06740646 0,11916592 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06740646 0,1190744 ! detection of calcium ion GO:0005513 13 9 0,000 0,06740646 0,11898301 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06740646 0,11889177 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06740646 0,11880066 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06740646 0,1187097 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06740646 0,11861887 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06740646 0,11852819 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06740646 0,11843764 ! prepulse inhibition GO:0060134 14 9 0,000 0,06740646 0,11834723 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06740646 0,11825695 ! insulin secretion GO:0030073 17 9 0,000 0,06740646 0,11816682 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06740646 0,11807682 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06740646 0,11798696 ! nucleus localization GO:0051647 15 9 0,000 0,06740646 0,11789724 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06740646 0,11780765 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,06742293 0,11774696 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,06957696 0,12141654 ! chromosome segregation GO:0007059 83 57 1,000 0,0717534 0,12511965 ! camera-type eye development GO:0043010 88 57 1,000 0,0717534 0,12502487 ! secondary metabolic process GO:0019748 84 57 1,000 0,0717534 0,12493022 ! viral reproductive process GO:0022415 87 58 1,000 0,0739518 0,12866048 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07461187 0,12971074 ! neuron fate specification GO:0048665 11 10 0,000 0,07461187 0,12961277 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07461187 0,12951495 ! thyroid gland development GO:0030878 19 10 0,000 0,07461187 0,12941728 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07461187 0,12931975 ! synapsis GO:0007129 13 10 0,000 0,07461187 0,12922237 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07461187 0,12912514 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07461187 0,12902805 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07461187 0,12893111 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,07461187 0,12883432 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07461187 0,12873767 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07461187 0,12864116 ! androgen metabolic process GO:0008209 13 10 0,000 0,07461187 0,1285448 ! phospholipid efflux GO:0033700 16 10 0,000 0,07461187 0,12844858 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07461187 0,12835251 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07461187 0,12825658 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07461187 0,1281608 ! pathogenesis GO:0009405 13 10 0,000 0,07461187 0,12806516 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07461187 0,12796966 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07461187 0,1278743 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07461187 0,12777908 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07461187 0,12768401 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07461187 0,12758908 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07461187 0,12749429 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07461187 0,12739964 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07461187 0,12730513 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07461187 0,12721076 ! forebrain cell migration GO:0021885 17 10 0,000 0,07461187 0,12711653 ! lipid digestion GO:0044241 15 10 0,000 0,07461187 0,12702243 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07461187 0,12692848 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07461187 0,12683467 ! UV protection GO:0009650 14 10 0,000 0,07461187 0,126741 ! entry into host cell GO:0030260 20 10 0,000 0,07461187 0,12664746 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07461187 0,12655406 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07461187 0,1264608 ! regulation of organ growth GO:0046620 11 10 0,000 0,07461187 0,12636768 ! response to dsRNA GO:0043331 18 10 0,000 0,07461187 0,12627469 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07461187 0,12618185 ! embryonic axis specification GO:0000578 12 10 0,000 0,07461187 0,12608913 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07461187 0,12599656 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07461187 0,12590412 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07461187 0,12581181 ! cranial nerve development GO:0021545 12 10 0,000 0,07461187 0,12571964 ! fucose catabolic process GO:0019317 16 10 0,000 0,07461187 0,12562761 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07461187 0,12553571 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07461187 0,12544394 ! protein sumoylation GO:0016925 12 10 0,000 0,07461187 0,12535231 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07461187 0,12526081 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07461187 0,12516945 ! zymogen activation GO:0031638 14 10 0,000 0,07461187 0,12507821 ! salivary gland development GO:0007431 22 10 0,000 0,07461187 0,12498712 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07461187 0,12489615 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07461187 0,12480532 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07461187 0,12471461 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07461187 0,12462404 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07461187 0,12453361 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07461187 0,1244433 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07461187 0,12435312 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07461187 0,12426308 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07461187 0,12417316 ! detection of bacterium GO:0016045 10 10 0,000 0,07461187 0,12408338 ! embryonic gut development GO:0048566 11 10 0,000 0,07461187 0,12399372 ! activation of innate immune response GO:0002218 10 10 0,000 0,07461187 0,12390419 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07461187 0,1238148 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07461187 0,12372553 ! developmental induction GO:0031128 13 10 0,000 0,07461187 0,12363639 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07461187 0,12354738 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07461187 0,1234585 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07461187 0,12336974 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,07841263 0,1295611 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07841263 0,12946809 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,07841263 0,12937522 ! fertilization GO:0009566 68 60 1,000 0,07841263 0,12928248 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,08067415 0,13291586 ! meiosis GO:0007126 96 61 1,000 0,08067415 0,13282072 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,08067415 0,13272571 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,08067415 0,13263084 ! rRNA transcription GO:0009303 17 11 0,000 0,08176202 0,13432332 ! respiratory burst GO:0045730 14 11 0,000 0,08176202 0,13422745 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08176202 0,13413171 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,08176202 0,1340361 ! filopodium assembly GO:0046847 19 11 0,000 0,08176202 0,13394063 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08176202 0,1338453 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08176202 0,13375011 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,08176202 0,13365505 ! mating GO:0007618 14 11 0,000 0,08176202 0,13356012 ! T cell proliferation GO:0042098 20 11 0,000 0,08176202 0,13346533 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08176202 0,13337067 ! bone resorption GO:0045453 16 11 0,000 0,08176202 0,13327615 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08176202 0,13318176 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08176202 0,13308751 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,08176202 0,13299339 ! syncytium formation GO:0006949 15 11 0,000 0,08176202 0,1328994 ! plasma membrane organization GO:0007009 18 11 0,000 0,08176202 0,13280554 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08176202 0,13271182 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08176202 0,13261823 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,08176202 0,13252477 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08176202 0,13243144 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08176202 0,13233825 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,08176202 0,13224518 ! temperature homeostasis GO:0001659 16 11 0,000 0,08176202 0,13215225 ! L-glutamate transport GO:0015813 16 11 0,000 0,08176202 0,13205945 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08176202 0,13196677 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08176202 0,13187423 ! stem cell development GO:0048864 29 11 0,000 0,08176202 0,13178182 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08176202 0,13168953 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08176202 0,13159738 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08176202 0,13150535 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08176202 0,13141345 ! vasoconstriction GO:0042310 15 11 0,000 0,08176202 0,13132168 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08176202 0,13123004 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08176202 0,13113853 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08176202 0,13104714 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08176202 0,13095589 ! ribosome assembly GO:0042255 13 11 0,000 0,08176202 0,13086475 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08176202 0,13077375 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08176202 0,13068287 ! chromatin silencing GO:0006342 19 11 0,000 0,08176202 0,13059212 ! nucleosome positioning GO:0016584 13 11 0,000 0,08176202 0,13050149 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08176202 0,13041099 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08176202 0,13032062 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08176202 0,13023037 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08176202 0,13014024 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08176202 0,13005024 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08176202 0,12996037 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08176202 0,12987062 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08176202 0,12978099 ! male genitalia development GO:0030539 13 11 0,000 0,08176202 0,12969148 ! cholesterol efflux GO:0033344 19 11 0,000 0,08176202 0,1296021 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08176202 0,12951285 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08176202 0,12942371 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,08176202 0,1293347 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,08176202 0,12924581 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08176202 0,12915704 ! defense response to fungus GO:0050832 12 11 0,000 0,08176202 0,12906839 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08176202 0,12897987 ! lysogeny GO:0030069 18 11 0,000 0,08176202 0,12889147 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08176202 0,12880319 ! acrosome reaction GO:0007340 13 11 0,000 0,08176202 0,12871502 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08176202 0,12862698 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,08295581 0,13041583 ! meiotic cell cycle GO:0051321 97 62 1,000 0,08295581 0,13032674 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,08525716 0,13385083 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,08525716 0,13375953 ! viral reproduction GO:0016032 92 63 1,000 0,08525716 0,13366835 ! regulation of lipase activity GO:0060191 109 63 1,000 0,08525716 0,13357729 ! adaptive immune response GO:0002250 94 64 1,000 0,08757778 0,13711973 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! lactation GO:0007595 20 12 0,000 0,08885733 0,13902848 ! reproductive cellular process GO:0048610 14 12 0,000 0,08885733 0,13893396 ! tRNA modification GO:0006400 14 12 0,000 0,08885733 0,13883958 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08885733 0,13874532 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08885733 0,13865119 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08885733 0,13855719 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08885733 0,13846332 ! non-recombinational repair GO:0000726 19 12 0,000 0,08885733 0,13836957 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08885733 0,13827595 ! peroxisomal transport GO:0043574 21 12 0,000 0,08885733 0,13818246 ! cartilage condensation GO:0001502 18 12 0,000 0,08885733 0,13808909 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08885733 0,13799585 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08885733 0,13790274 ! palate development GO:0060021 15 12 0,000 0,08885733 0,13780975 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08885733 0,13771689 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08885733 0,13762415 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08885733 0,13753153 ! arginine metabolic process GO:0006525 13 12 0,000 0,08885733 0,13743904 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08885733 0,13734668 ! methionine metabolic process GO:0006555 13 12 0,000 0,08885733 0,13725444 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08885733 0,13716232 ! Golgi organization GO:0007030 18 12 0,000 0,08885733 0,13707033 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08885733 0,13697846 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08885733 0,13688671 ! monoamine transport GO:0015844 13 12 0,000 0,08885733 0,13679509 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08885733 0,13670359 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08885733 0,13661221 ! L-amino acid transport GO:0015807 20 12 0,000 0,08885733 0,13652095 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08885733 0,13642981 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08885733 0,1363388 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08885733 0,13624791 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08885733 0,13615714 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08885733 0,13606648 ! cerebellum development GO:0021549 13 12 0,000 0,08885733 0,13597595 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08885733 0,13588555 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08885733 0,13579526 ! histone methylation GO:0016571 15 12 0,000 0,08885733 0,13570509 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08885733 0,13561504 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08885733 0,13552511 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08885733 0,13543529 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08885733 0,1353456 ! intestinal absorption GO:0050892 19 12 0,000 0,08885733 0,13525603 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08885733 0,13516657 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08885733 0,13507724 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08885733 0,13498802 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08885733 0,13489892 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08885733 0,13480993 ! microspike assembly GO:0030035 23 12 0,000 0,08885733 0,13472107 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08885733 0,13463232 ! response to cold GO:0009409 14 12 0,000 0,08885733 0,13454369 ! regulation of caspase activity GO:0043281 97 65 1,000 0,08991723 0,13605896 ! B cell activation GO:0042113 104 65 1,000 0,08991723 0,13596951 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,08991723 0,13588018 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08991723 0,13579096 ! protein oligomerization GO:0051259 100 65 1,000 0,08991723 0,13570185 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,09227509 0,13916899 ! axon guidance GO:0007411 99 66 1,000 0,09227509 0,13907779 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,09465094 0,14256527 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09589822 0,14434941 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09589822 0,144255 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09589822 0,14416072 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,09589822 0,14406655 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09589822 0,14397252 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09589822 0,1438786 ! lipid localization GO:0010876 24 13 0,000 0,09589822 0,14378481 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09589822 0,14369114 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09589822 0,14359759 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09589822 0,14350416 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09589822 0,14341086 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,09589822 0,14331767 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09589822 0,14322461 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09589822 0,14313166 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09589822 0,14303884 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,09589822 0,14294614 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09589822 0,14285356 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09589822 0,1427611 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09589822 0,14266875 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09589822 0,14257653 ! NAD metabolic process GO:0019674 21 13 0,000 0,09589822 0,14248443 ! exocrine system development GO:0035272 27 13 0,000 0,09589822 0,14239244 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09589822 0,14230058 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09589822 0,14220883 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09589822 0,1421172 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09589822 0,14202569 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09589822 0,1419343 ! genitalia development GO:0048806 15 13 0,000 0,09589822 0,14184302 ! regulation of cellular pH GO:0030641 20 13 0,000 0,09589822 0,14175186 ! tissue regeneration GO:0042246 21 13 0,000 0,09589822 0,14166082 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09589822 0,14156989 ! cofactor transport GO:0051181 19 13 0,000 0,09589822 0,14147909 ! NADP metabolic process GO:0006739 18 13 0,000 0,09589822 0,14138839 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09589822 0,14129782 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09589822 0,14120736 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09589822 0,14111702 ! gas transport GO:0015669 18 13 0,000 0,09589822 0,14102679 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09589822 0,14093667 ! regulation of axon extension GO:0030516 23 13 0,000 0,09589822 0,14084668 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09589822 0,14075679 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09589822 0,14066702 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09589822 0,14057737 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09589822 0,14048783 ! rhythmic process GO:0048511 105 68 1,000 0,09704438 0,14207643 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,09945498 0,14551301 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,09945498 0,1454205 ! humoral immune response GO:0006959 86 70 1,000 0,10188235 0,14887509 ! eye development GO:0001654 111 70 1,000 0,10188235 0,14878057 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,10188235 0,14868617 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,10288509 0,15005435 ! superoxide anion generation GO:0042554 18 14 0,000 0,10288509 0,14995926 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10288509 0,14986429 ! myotube differentiation GO:0014902 21 14 0,000 0,10288509 0,14976944 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,10288509 0,14967471 ! inositol metabolic process GO:0006020 20 14 0,000 0,10288509 0,1495801 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10288509 0,1494856 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10288509 0,14939123 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10288509 0,14929698 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10288509 0,14920284 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10288509 0,14910883 ! response to cAMP GO:0051591 19 14 0,000 0,10288509 0,14901493 ! startle response GO:0001964 21 14 0,000 0,10288509 0,14892115 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,10288509 0,14882749 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10288509 0,14873395 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10288509 0,14864052 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10288509 0,14854721 ! glycine metabolic process GO:0006544 22 14 0,000 0,10288509 0,14845402 ! cellular response to starvation GO:0009267 21 14 0,000 0,10288509 0,14836095 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,10288509 0,14826799 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,10288509 0,14817515 ! regulation of heart rate GO:0002027 23 14 0,000 0,10288509 0,14808242 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10288509 0,14798981 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10288509 0,14789732 ! embryo implantation GO:0007566 27 14 0,000 0,10288509 0,14780494 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,10288509 0,14771268 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10288509 0,14762053 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,10288509 0,1475285 ! axon cargo transport GO:0008088 27 14 0,000 0,10288509 0,14743658 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10288509 0,14734478 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,10288509 0,14725309 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,10288509 0,14716151 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10288509 0,14707005 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10288509 0,1469787 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10288509 0,14688747 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10288509 0,14679635 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10288509 0,14670534 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10288509 0,14661444 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10288509 0,14652366 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10288509 0,14643299 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,10288509 0,14634243 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10288509 0,14625198 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10288509 0,14616165 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10288509 0,14607143 ! cell killing GO:0001906 20 14 0,000 0,10288509 0,14598131 ! cilium assembly GO:0042384 20 14 0,000 0,10288509 0,14589131 ! peptide hormone secretion GO:0030072 23 14 0,000 0,10288509 0,14580142 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,10432609 0,14775246 ! muscle cell differentiation GO:0042692 104 71 1,000 0,10432609 0,14766154 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,1067858 0,15105003 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,1067858 0,15095719 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,1067858 0,15086446 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,1067858 0,15077185 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,1092611 0,15417211 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10981837 0,15486343 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10981837 0,15476854 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10981837 0,15467376 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10981837 0,1545791 ! skin development GO:0043588 25 15 0,000 0,10981837 0,15448456 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10981837 0,15439013 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10981837 0,15429582 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10981837 0,15420162 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10981837 0,15410754 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10981837 0,15401357 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10981837 0,15391971 ! adult walking behavior GO:0007628 25 15 0,000 0,10981837 0,15382598 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10981837 0,15373235 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10981837 0,15363884 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10981837 0,15354544 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10981837 0,15345216 ! cerebral cortex development GO:0021987 29 15 0,000 0,10981837 0,15335899 ! response to osmotic stress GO:0006970 22 15 0,000 0,10981837 0,15326593 ! vesicle coating GO:0006901 25 15 0,000 0,10981837 0,15317298 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10981837 0,15308015 ! DNA integration GO:0015074 22 15 0,000 0,10981837 0,15298743 ! peptide secretion GO:0002790 27 15 0,000 0,10981837 0,15289483 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10981837 0,15280233 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10981837 0,15270995 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10981837 0,15261767 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10981837 0,15252551 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10981837 0,15243347 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10981837 0,15234153 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10981837 0,1522497 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10981837 0,15215798 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10981837 0,15206638 ! organic cation transport GO:0015695 19 15 0,000 0,10981837 0,15197488 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10981837 0,15188349 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10981837 0,15179222 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,10981837 0,15170105 ! peptide hormone processing GO:0016486 19 15 0,000 0,10981837 0,15160999 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10981837 0,15151905 ! protein import into nucleus GO:0006606 118 74 1,000 0,11175161 0,15409395 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,11175161 0,15400163 ! nuclear import GO:0051170 121 75 1,000 0,11425695 0,15735987 ! protein secretion GO:0009306 27 16 0,000 0,11669846 0,16062625 ! hormone secretion GO:0046879 25 16 0,000 0,11669846 0,16053018 ! bone remodeling GO:0046849 24 16 0,000 0,11669846 0,16043422 ! endothelial cell migration GO:0043542 22 16 0,000 0,11669846 0,16033839 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11669846 0,16024266 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11669846 0,16014705 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11669846 0,16005155 ! glial cell development GO:0021782 24 16 0,000 0,11669846 0,15995617 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11669846 0,1598609 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11669846 0,15976575 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11669846 0,15967071 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11669846 0,15957578 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11669846 0,15948096 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11669846 0,15938626 ! fructose metabolic process GO:0006000 20 16 0,000 0,11669846 0,15929167 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11669846 0,15919719 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11669846 0,15910282 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11669846 0,15900856 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11669846 0,15891442 ! DNA replication initiation GO:0006270 25 16 0,000 0,11669846 0,15882039 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11669846 0,15872647 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11669846 0,15863266 ! G1 phase GO:0051318 27 16 0,000 0,11669846 0,15853896 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11669846 0,15844537 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11669846 0,15835189 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11669846 0,15825852 ! steroid catabolic process GO:0006706 22 16 0,000 0,11669846 0,15816527 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,11669846 0,15807212 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11669846 0,15797908 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11669846 0,15788615 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11669846 0,15779333 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11669846 0,15770062 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11669846 0,15760802 ! nerve development GO:0021675 18 16 0,000 0,11669846 0,15751553 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11669846 0,15742314 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11669846 0,15733087 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,11931062 0,16075831 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,11931062 0,16066419 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,11931062 0,16057018 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,12185823 0,16390288 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12352576 0,16604866 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,12352576 0,16595167 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12352576 0,16585479 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,12352576 0,16575803 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12352576 0,16566138 ! glycerol metabolic process GO:0006071 20 17 0,000 0,12352576 0,16556484 ! zinc ion transport GO:0006829 20 17 0,000 0,12352576 0,16546841 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12352576 0,16537209 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12352576 0,16527589 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,12352576 0,1651798 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12352576 0,16508382 ! memory GO:0007613 25 17 0,000 0,12352576 0,16498795 ! keratinization GO:0031424 17 17 0,000 0,12352576 0,1648922 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12352576 0,16479655 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,12352576 0,16470102 ! retinoid metabolic process GO:0001523 22 17 0,000 0,12352576 0,1646056 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,12352576 0,16451028 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12352576 0,16441508 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12352576 0,16431999 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12352576 0,164225 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12352576 0,16413013 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,12352576 0,16403537 ! membrane budding GO:0006900 29 17 0,000 0,12352576 0,16394071 ! heme metabolic process GO:0042168 27 17 0,000 0,12352576 0,16384617 ! actin filament bundle formation GO:0051017 26 17 0,000 0,12352576 0,16375173 ! body fluid secretion GO:0007589 27 17 0,000 0,12352576 0,16365741 ! stem cell differentiation GO:0048863 36 17 0,000 0,12352576 0,16356319 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12352576 0,16346908 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12352576 0,16337508 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12352576 0,16328118 ! sensory perception of pain GO:0019233 23 17 0,000 0,12352576 0,1631874 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,12352576 0,16309372 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12352576 0,16300015 ! synaptogenesis GO:0007416 24 17 0,000 0,12352576 0,16290668 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12352576 0,16281333 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,12352576 0,16272008 ! cell-cell junction organization GO:0045216 25 17 0,000 0,12352576 0,16262694 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,12352576 0,1625339 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,12352576 0,16244097 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12352576 0,16234815 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,12352576 0,16225543 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,12352576 0,16216282 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,12441919 0,16324252 ! cellular respiration GO:0045333 107 79 1,000 0,12441919 0,16314945 ! oxidative phosphorylation GO:0006119 105 79 1,000 0,12441919 0,16305649 ! regulation of lyase activity GO:0051339 133 79 1,000 0,12441919 0,16296364 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,12699317 0,16624035 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,12699317 0,16614579 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,12957981 0,16943352 ! response to protein stimulus GO:0051789 111 81 1,000 0,12957981 0,16933725 ! regulation of neurological system process GO:0031644 122 81 1,000 0,12957981 0,16924109 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,12957981 0,16914504 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of translation GO:0045727 28 18 0,000 0,13030069 0,16998955 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,13030069 0,16989319 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,13030069 0,16979693 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13030069 0,16970078 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13030069 0,16960474 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13030069 0,16950881 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13030069 0,16941299 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13030069 0,16931728 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,13030069 0,16922167 ! pancreas development GO:0031016 26 18 0,000 0,13030069 0,16912617 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13030069 0,16903078 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13030069 0,1689355 ! response to retinoic acid GO:0032526 25 18 0,000 0,13030069 0,16884033 ! pigmentation during development GO:0048066 31 18 0,000 0,13030069 0,16874526 ! central nervous system neuron development GO:0021954 30 18 0,000 0,13030069 0,1686503 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13030069 0,16855544 ! fucose metabolic process GO:0006004 26 18 0,000 0,13030069 0,1684607 ! response to fungus GO:0009620 19 18 0,000 0,13030069 0,16836606 ! peptide cross-linking GO:0018149 31 18 0,000 0,13030069 0,16827152 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,13030069 0,16817709 ! heart process GO:0003015 27 18 0,000 0,13030069 0,16808277 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,13030069 0,16798855 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,13030069 0,16789444 ! visual learning GO:0008542 35 18 0,000 0,13030069 0,16780044 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13030069 0,16770654 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13030069 0,16761274 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,13030069 0,16751905 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13030069 0,16742546 ! vitamin transport GO:0051180 24 18 0,000 0,13030069 0,16733198 ! hormone transport GO:0009914 27 18 0,000 0,13030069 0,1672386 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13030069 0,16714533 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,13030069 0,16705216 ! cell-cell recognition GO:0009988 20 18 0,000 0,13030069 0,1669591 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13030069 0,16686614 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13030069 0,16677328 ! regulation of glucose import GO:0046324 21 18 0,000 0,13030069 0,16668052 GO:0010827|regulation of glucose transport, ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,13030069 0,16658787 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,13478969 0,17223127 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13702363 0,17498853 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13702363 0,17489142 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13702363 0,17479442 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13702363 0,17469753 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13702363 0,17460074 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13702363 0,17450406 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13702363 0,17440749 ! sensory perception of taste GO:0050909 23 19 0,000 0,13702363 0,17431103 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13702363 0,17421467 ! peroxisome organization GO:0007031 29 19 0,000 0,13702363 0,17411842 ! digestive system process GO:0022600 30 19 0,000 0,13702363 0,17402227 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13702363 0,17392624 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13702363 0,1738303 ! response to vitamin A GO:0033189 26 19 0,000 0,13702363 0,17373448 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13702363 0,17363875 ! response to starvation GO:0042594 30 19 0,000 0,13702363 0,17354314 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13702363 0,17344763 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13702363 0,17335222 ! cytolysis GO:0019835 20 19 0,000 0,13702363 0,17325692 ! vasodilation GO:0042311 33 19 0,000 0,13702363 0,17316173 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13702363 0,17306663 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13702363 0,17297165 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13702363 0,17287676 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13702363 0,17278198 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13702363 0,17268731 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13702363 0,17259274 ! sarcomere organization GO:0045214 23 19 0,000 0,13702363 0,17249827 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13702363 0,17240391 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13702363 0,17230964 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13702363 0,17221549 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13702363 0,17212143 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13702363 0,17202748 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,13702363 0,17193363 ! regulation of defense response GO:0031347 117 84 1,000 0,13741226 0,17232726 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,14004613 0,17553466 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,14269098 0,17875232 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,14369498 0,17991206 ! iron ion transport GO:0006826 37 20 0,000 0,14369498 0,17981417 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,14369498 0,17971639 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,14369498 0,17961872 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,14369498 0,17952116 ! response to vitamin GO:0033273 29 20 0,000 0,14369498 0,1794237 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,14369498 0,17932634 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,14369498 0,17922909 ! spinal cord development GO:0021510 31 20 0,000 0,14369498 0,17913195 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,14369498 0,17903491 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,14369498 0,17893798 ! chromosome condensation GO:0030261 31 20 0,000 0,14369498 0,17884115 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,14369498 0,17874443 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,14369498 0,17864781 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,14369498 0,1785513 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,14369498 0,17845489 ! DNA modification GO:0006304 28 20 0,000 0,14369498 0,17835858 ! collagen fibril organization GO:0030199 45 20 0,000 0,14369498 0,17826238 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,14369498 0,17816628 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,14369498 0,17807028 ! collagen catabolic process GO:0030574 25 20 0,000 0,14369498 0,17797439 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,14369498 0,17787861 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,14369498 0,17778292 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,14369498 0,17768734 ! alditol metabolic process GO:0019400 24 20 0,000 0,14369498 0,17759186 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,14534649 0,17953649 ! establishment of RNA localization GO:0051236 128 88 1,000 0,14801234 0,18273129 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,15031513 0,18547468 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,15031513 0,18537523 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,15031513 0,18527589 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,15031513 0,18517665 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,15031513 0,18507752 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,15031513 0,1849785 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,15031513 0,18487958 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,15031513 0,18478076 GO:0034105|positive regulation of tissue remodeling, ! vesicle docking GO:0048278 27 21 0,000 0,15031513 0,18468206 ! phototransduction GO:0007602 25 21 0,000 0,15031513 0,18458345 ! dendrite development GO:0016358 35 21 0,000 0,15031513 0,18448496 ! visual behavior GO:0007632 39 21 0,000 0,15031513 0,18438656 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,15031513 0,18428828 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,15031513 0,1841901 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,15031513 0,18409202 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,15031513 0,18399404 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,15031513 0,18389617 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,15031513 0,18379841 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,15031513 0,18370075 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,15031513 0,18360319 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,15031513 0,18350574 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,15031513 0,18340839 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,15031513 0,18331114 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,15031513 0,183214 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,15031513 0,18311695 ! fatty acid transport GO:0015908 30 21 0,000 0,15031513 0,18302002 ! immunoglobulin production GO:0002377 33 21 0,000 0,15031513 0,18292318 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,15031513 0,18282645 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,15031513 0,18272981 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,15031513 0,18263329 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,15031513 0,18253686 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,15031513 0,18244053 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,15031513 0,18234431 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,15031513 0,18224819 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,15031513 0,18215216 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,15031513 0,18205624 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,15031513 0,18196043 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,15068822 0,1823161 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,15068822 0,18222024 ! RNA localization GO:0006403 135 91 1,000 0,1560688 0,18862755 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,15688449 0,18951382 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15688449 0,18941434 ! viral genome replication GO:0019079 29 22 0,000 0,15688449 0,18931496 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15688449 0,18921569 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15688449 0,18911652 ! leukocyte adhesion GO:0007159 38 22 0,000 0,15688449 0,18901745 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,15688449 0,18891849 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,15688449 0,18881963 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15688449 0,18872088 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,15688449 0,18862223 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15688449 0,18852368 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15688449 0,18842523 ! lysosome organization GO:0007040 37 22 0,000 0,15688449 0,18832689 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15688449 0,18822865 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15688449 0,18813051 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15688449 0,18803247 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15688449 0,18793454 ! membrane depolarization GO:0051899 35 22 0,000 0,15688449 0,18783671 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15688449 0,18773898 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15688449 0,18764135 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15688449 0,18754382 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15688449 0,1874464 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,1587729 0,18960419 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,1587729 0,18950579 ! DNA recombination GO:0006310 146 92 1,000 0,1587729 0,1894075 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,1614858 0,19254398 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,16340342 0,19472947 ! neuron fate commitment GO:0048663 32 23 0,000 0,16340342 0,19462862 ! embryonic pattern specification GO:0009880 31 23 0,000 0,16340342 0,19452788 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,16340342 0,19442725 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,16340342 0,19432672 ! vesicle targeting GO:0006903 32 23 0,000 0,16340342 0,19422629 ! osteoblast differentiation GO:0001649 40 23 0,000 0,16340342 0,19412596 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,16340342 0,19402574 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,16340342 0,19392563 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,16340342 0,19382562 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16340342 0,19372571 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16340342 0,1936259 ! cell fate determination GO:0001709 45 23 0,000 0,16340342 0,19352619 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,16340342 0,19342659 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16340342 0,19332709 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,16340342 0,1932277 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16340342 0,1931284 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,16340342 0,19302921 ! telomere organization GO:0032200 32 23 0,000 0,16340342 0,19293012 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16340342 0,19283113 ! regulation of amine transport GO:0051952 38 23 0,000 0,16340342 0,19273224 ! liver development GO:0001889 40 23 0,000 0,16340342 0,19263345 ! electron transport chain GO:0022900 123 94 1,000 0,16420722 0,19348187 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,16967444 0,19982141 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16987232 0,19995207 ! initiation of viral infection GO:0019059 42 24 0,000 0,16987232 0,19984979 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16987232 0,19974762 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,16987232 0,19964555 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16987232 0,19954359 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16987232 0,19944173 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,16987232 0,19933997 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16987232 0,19923832 ! sperm motility GO:0030317 27 24 0,000 0,16987232 0,19913677 ! vacuole organization GO:0007033 39 24 0,000 0,16987232 0,19903532 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16987232 0,19893398 ! base-excision repair GO:0006284 31 24 0,000 0,16987232 0,19883274 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16987232 0,19873161 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16987232 0,19863057 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16987232 0,19852964 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,16987232 0,19842882 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,16987232 0,19832809 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,17241967 0,20120002 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17629157 0,2056139 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17629157 0,20550969 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17629157 0,20540558 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17629157 0,20530157 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,17629157 0,20519768 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17629157 0,20509388 ! peptide transport GO:0015833 43 25 0,000 0,17629157 0,2049902 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,17629157 0,20488661 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17629157 0,20478314 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,17629157 0,20467976 ! phospholipid transport GO:0015914 35 25 0,000 0,17629157 0,20457649 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17629157 0,20447333 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17629157 0,20437027 ! detection of light stimulus GO:0009583 30 25 0,000 0,17629157 0,20426731 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,17629157 0,20416446 GO:0045840|positive regulation of mitosis, ! extracellular structure organization GO:0043062 156 99 1,000 0,17793199 0,20596053 ! protein import GO:0017038 156 99 1,000 0,17793199 0,20585693 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,17793199 0,20575343 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,18069853 0,20884754 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,18069853 0,20874265 ! protein localization in organelle GO:0033365 161 100 1,000 0,18069853 0,20863786 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,18266154 0,21079857 ! regulation of pH GO:0006885 36 26 0,000 0,18266154 0,21069285 ! circadian rhythm GO:0007623 42 26 0,000 0,18266154 0,21058724 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,18266154 0,21048174 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,18266154 0,21037634 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,18266154 0,21027105 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,18266154 0,21016586 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,18266154 0,21006078 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,18266154 0,2099558 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,18266154 0,20985092 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,18266154 0,20974616 ! regulation of coagulation GO:0050818 39 26 0,000 0,18266154 0,20964149 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18898262 0,21678804 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,18898262 0,21667997 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18898262 0,21657201 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18898262 0,21646416 ! membrane docking GO:0022406 39 27 0,000 0,18898262 0,21635641 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18898262 0,21624877 ! catechol metabolic process GO:0009712 43 27 0,000 0,18898262 0,21614124 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18898262 0,21603381 ! acute-phase response GO:0006953 42 27 0,000 0,18898262 0,21592649 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18898262 0,21581928 ! myofibril assembly GO:0030239 36 27 0,000 0,18898262 0,21571217 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18898262 0,21560517 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,18898262 0,21549828 ! natural killer cell activation GO:0030101 35 27 0,000 0,18898262 0,21539149 ! lipid oxidation GO:0034440 38 27 0,000 0,18898262 0,21528481 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18898262 0,21517823 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18898262 0,21507176 ! gene silencing GO:0016458 41 27 0,000 0,18898262 0,21496539 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,19525517 0,22199055 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,19525517 0,22188087 ! phenol metabolic process GO:0018958 44 28 0,000 0,19525517 0,2217713 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,19525517 0,22166184 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,19525517 0,22155249 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,19525517 0,22144324 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,19525517 0,2213341 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,19525517 0,22122507 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,19525517 0,22111614 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,19525517 0,22100733 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,19525517 0,22089862 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,19525517 0,22079001 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,19525517 0,22068152 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,19525517 0,22057313 ! mesoderm formation GO:0001707 46 28 0,000 0,19525517 0,22046484 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,19525517 0,22035667 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,19525517 0,2202486 ! BMP signaling pathway GO:0030509 40 28 0,000 0,19525517 0,22014063 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,19525517 0,22003277 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,19525517 0,21992502 ! regulation of innate immune response GO:0045088 38 29 0,000 0,20147956 0,22682476 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,20147956 0,22671379 ! protein targeting to membrane GO:0006612 53 29 0,000 0,20147956 0,22660293 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,20147956 0,22649218 ! mismatch repair GO:0006298 34 29 0,000 0,20147956 0,22638153 ! muscle cell development GO:0055001 38 29 0,000 0,20147956 0,22627099 ! formation of primary germ layer GO:0001704 48 29 0,000 0,20147956 0,22616056 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,20147956 0,22605024 ! eye morphogenesis GO:0048592 51 29 0,000 0,20147956 0,22594002 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,20147956 0,22582992 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20765616 0,23263964 ! organic anion transport GO:0015711 51 30 0,000 0,20765616 0,23252638 ! cholesterol transport GO:0030301 46 30 0,000 0,20765616 0,23241323 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,20765616 0,23230018 ! spliceosome assembly GO:0000245 49 30 0,000 0,20765616 0,23218725 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20765616 0,23207443 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20765616 0,23196172 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,20765616 0,23184912 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20765616 0,23173662 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20765616 0,23162424 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20765616 0,23151196 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,20765616 0,2313998 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,20765616 0,23128774 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,20765616 0,23117579 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,21378534 0,23788403 ! negative regulation of secretion GO:0051048 49 31 0,000 0,21378534 0,237769 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,21378534 0,23765408 ! odontogenesis GO:0042476 50 31 0,000 0,21378534 0,23753927 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,21378534 0,23742457 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,21378534 0,23730998 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,21378534 0,23719551 ! cell fate specification GO:0001708 37 31 0,000 0,21378534 0,23708114 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,21378534 0,23696689 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,21378534 0,23685274 ! RNA modification GO:0009451 40 31 0,000 0,21378534 0,2367387 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,21986746 0,24335667 ! meiosis I GO:0007127 52 32 0,000 0,21986746 0,24323961 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,21986746 0,24312267 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,21986746 0,24300584 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,21986746 0,24288912 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,21986746 0,24277252 ! vesicle localization GO:0051648 47 32 0,000 0,21986746 0,24265602 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,22590287 0,24919741 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,22590287 0,24907795 ! ear morphogenesis GO:0042471 42 33 0,000 0,22590287 0,2489586 ! actomyosin structure organization GO:0031032 43 33 0,000 0,22590287 0,24883936 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,22590287 0,24872025 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,22590287 0,24860124 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,22590287 0,24848235 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,22590287 0,24836357 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,22590287 0,24824491 ! mRNA catabolic process GO:0006402 48 34 0,000 0,23189193 0,2547046 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,23189193 0,25458302 ! feeding behavior GO:0007631 45 34 0,000 0,23189193 0,25446156 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,23189193 0,25434022 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,23189193 0,25421899 ! polyol metabolic process GO:0019751 44 34 0,000 0,23189193 0,25409787 ! aerobic respiration GO:0009060 47 34 0,000 0,23189193 0,25397687 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,23189193 0,25385599 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,23783499 0,2602381 ! Notch signaling pathway GO:0007219 56 35 0,000 0,23783499 0,26011435 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,23783499 0,25999072 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,23783499 0,25986721 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,23783499 0,25974382 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,23783499 0,25962054 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,23783499 0,25949738 ! protein homooligomerization GO:0051260 52 35 0,000 0,23783499 0,25937434 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,24373241 0,26567988 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,24373241 0,26555402 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,24373241 0,26542829 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,24373241 0,26530267 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,24373241 0,26517717 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,24958453 0,2714158 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,24958453 0,27128754 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,24958453 0,27115939 ! ion transmembrane transport GO:0034220 56 37 0,000 0,24958453 0,27103136 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,24958453 0,27090346 ! regulation of protein secretion GO:0050708 51 37 0,000 0,24958453 0,27077567 ! amino acid activation GO:0043038 52 37 0,000 0,24958453 0,27064801 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,24958453 0,27052046 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,2553917 0,27668437 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,2553917 0,2765541 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,2553917 0,27642396 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,2553917 0,27629394 ! phagocytosis GO:0006909 60 38 0,000 0,2553917 0,27616404 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,26115426 0,2822626 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,26115426 0,28213002 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,26115426 0,28199756 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,26115426 0,28186523 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,26115426 0,28173302 ! cell growth GO:0016049 61 39 0,000 0,26115426 0,28160094 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,26687256 0,28763209 ! regulation of tube size GO:0035150 60 40 0,000 0,26687256 0,28749737 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,26687256 0,28736277 ! peptide metabolic process GO:0006518 56 40 0,000 0,26687256 0,2872283 ! inner ear development GO:0048839 57 40 0,000 0,26687256 0,28709396 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,26687256 0,28695974 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,26687256 0,28682565 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,27254692 0,29278744 ! striated muscle contraction GO:0006941 62 41 0,000 0,27254692 0,29265075 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,27254692 0,29251419 ! biopolymer methylation GO:0043414 62 41 0,000 0,27254692 0,29237776 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,27817768 0,2982791 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,27817768 0,29814011 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,27817768 0,29800124 ! excretion GO:0007588 63 42 0,000 0,27817768 0,29786251 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,27817768 0,2977239 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,27817768 0,29758543 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,27817768 0,29744708 ! leukocyte migration GO:0050900 60 43 0,000 0,28376518 0,30328063 ! neuromuscular process GO:0050905 79 43 0,000 0,28376518 0,30313977 ! tRNA processing GO:0008033 49 43 0,000 0,28376518 0,30299904 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,28376518 0,30285843 ! methylation GO:0032259 64 43 0,000 0,28376518 0,30271796 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,28930975 0,30848977 ! glycolysis GO:0006096 53 44 0,000 0,28930975 0,30834681 ! regulation of ion transport GO:0043269 57 44 0,000 0,28930975 0,308204 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,28930975 0,30806131 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,28930975 0,30791875 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,28930975 0,30777633 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,28930975 0,30763404 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,28930975 0,30749188 ! RNA catabolic process GO:0006401 64 45 0,000 0,29481171 0,31319489 ! regulation of translational initiation GO:0006446 64 45 0,000 0,29481171 0,31305029 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,29481171 0,31290583 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,30027139 0,3185536 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,30027139 0,31840673 ! cell redox homeostasis GO:0045454 63 46 0,000 0,30027139 0,31826 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,30027139 0,3181134 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,30027139 0,31796694 ! viral infectious cycle GO:0019058 71 47 0,000 0,30568911 0,32355497 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,30568911 0,32340614 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,30568911 0,32325745 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,30568911 0,32310889 ! chloride transport GO:0006821 67 48 0,000 0,31106519 0,3286403 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,31106519 0,32848941 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,31106519 0,32833866 ! gastrulation GO:0007369 73 48 0,000 0,31106519 0,32818804 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,31106519 0,32803757 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,31106519 0,32788723 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,31106519 0,32773703 ! regulation of endocytosis GO:0030100 63 48 0,000 0,31106519 0,32758697 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,31639995 0,33305258 ! sensory perception of smell GO:0007608 61 49 0,000 0,31639995 0,33290022 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,31639995 0,332748 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,31639995 0,33259593 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,31639995 0,33244399 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,31639995 0,33229218 ! regulation of actin filament length GO:0030832 72 50 0,000 0,3216937 0,33769763 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,3216937 0,33754358 ! proton transport GO:0015992 75 50 0,000 0,3216937 0,33738966 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,3216937 0,33723588 ! positive regulation of secretion GO:0051047 71 51 0,000 0,32694676 0,34258659 ! hydrogen transport GO:0006818 77 51 0,000 0,32694676 0,34243058 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,32694676 0,34227472 ! adult behavior GO:0030534 80 51 0,000 0,32694676 0,342119 ! transition metal ion transport GO:0000041 74 52 0,000 0,33215944 0,34741551 ! regulation of cellular component size GO:0032535 74 52 0,000 0,33215944 0,3472576 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,33215944 0,34709983 ! establishment of organelle localization GO:0051656 85 52 0,000 0,33215944 0,3469422 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,33733205 0,35218507 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,33733205 0,35202527 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,33733205 0,35186563 ! amino acid transport GO:0006865 84 54 0,000 0,34246488 0,35705767 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,34246488 0,35689589 ! glucose catabolic process GO:0006007 66 54 0,000 0,34246488 0,35673425 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,34246488 0,35657276 ! detection of external stimulus GO:0009581 66 54 0,000 0,34246488 0,35641141 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,34246488 0,35625021 ! exocytosis GO:0006887 74 55 0,000 0,34755825 0,36138516 ! mesoderm development GO:0007498 76 55 0,000 0,34755825 0,36122186 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,34755825 0,3610587 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,35261245 0,36614386 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,35261245 0,36597863 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,35762779 0,37101666 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,35762779 0,37084938 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,36260457 0,3758407 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,36260457 0,3756714 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,36754306 0,38061641 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,36754306 0,38044512 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,37244358 0,38534423 ! regulation of heart contraction GO:0008016 91 60 0,000 0,37244358 0,38517097 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,37244358 0,38499786 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,3773064 0,38984938 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,3773064 0,38967433 ! extracellular matrix organization GO:0030198 103 61 0,000 0,3773064 0,38949943 ! amine catabolic process GO:0009310 90 62 0,000 0,38213182 0,39430381 ! neurotransmitter transport GO:0006836 81 62 0,000 0,38213182 0,39412699 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,38213182 0,39395033 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,38213182 0,39377383 ! organelle localization GO:0051640 96 62 0,000 0,38213182 0,39359749 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,39167159 0,40324291 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,39167159 0,40306249 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,39167159 0,40288223 ! hexose catabolic process GO:0019320 82 64 0,000 0,39167159 0,40270213 ! defense response to bacterium GO:0042742 73 65 0,000 0,3963865 0,40736772 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,3963865 0,40718578 ! activation of immune response GO:0002253 83 65 0,000 0,3963865 0,407004 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,40106514 0,41162419 ! antigen processing and presentation GO:0019882 96 66 0,000 0,40106514 0,4114406 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,40106514 0,41125716 ! regulation of immune effector process GO:0002697 101 66 0,000 0,40106514 0,41107389 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,40570778 0,41564717 ! acute inflammatory response GO:0002526 92 68 0,000 0,41031469 0,42017979 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,41031469 0,41999279 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,41031469 0,41980596 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,41031469 0,4196193 ! inorganic anion transport GO:0015698 93 68 0,000 0,41031469 0,4194328 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,41488616 0,42391745 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,41942245 0,42836218 ! amine transport GO:0015837 101 70 0,000 0,41942245 0,42817205 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,42392382 0,43257533 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,42392382 0,4323835 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,42392382 0,43219184 ! regulation of blood pressure GO:0008217 107 73 0,000 0,43282291 0,44106898 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,43722115 0,44535369 ! digestion GO:0007586 97 74 0,000 0,43722115 0,44515655 ! blood coagulation GO:0007596 116 75 0,000 0,44158553 0,4494012 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,44158553 0,44920244 ! amine biosynthetic process GO:0009309 97 76 0,000 0,44591631 0,45340739 ! tRNA metabolic process GO:0006399 95 76 0,000 0,44591631 0,45320703 ! response to unfolded protein GO:0006986 99 76 0,000 0,44591631 0,45300686 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,45021376 0,4571707 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,45021376 0,45696895 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,45447811 0,46109381 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,45447811 0,4608905 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,45870964 0,46497672 ! chromatin assembly GO:0031497 102 80 0,000 0,46290858 0,46902632 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,46290858 0,46881979 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,46290858 0,46861344 ! hemostasis GO:0007599 125 81 0,000 0,46707519 0,47262338 ! mRNA transport GO:0051028 121 81 0,000 0,46707519 0,47241554 ! vitamin metabolic process GO:0006766 103 81 0,000 0,46707519 0,47220789 ! detection of stimulus GO:0051606 108 82 0,000 0,47120971 0,47617853 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,4753124 0,48011353 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,47938348 0,48401318 ! sterol metabolic process GO:0016125 120 84 0,000 0,47938348 0,4838008 ! nucleosome organization GO:0034728 114 87 0,000 0,49140957 0,49572018 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,49140957 0,49550285 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,49140957 0,49528571 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,49535666 0,49904526 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,49535666 0,49882676 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,49535666 0,49860845 ! hormone metabolic process GO:0042445 121 90 0,000 0,50315986 0,50624133 ! ATP metabolic process GO:0046034 137 91 0,000 0,50701643 0,50989846 ! positive regulation of immune response GO:0050778 121 92 0,000 0,51084328 0,51352253 ! sulfur metabolic process GO:0006790 118 92 0,000 0,51084328 0,51329818 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,51464064 0,51688798 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,51464064 0,51666236 ! carboxylic acid transport GO:0046942 147 95 0,000 0,52214781 0,52397031 GO:0015849|organic acid transport, ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,52585805 0,52746337 ! protein maturation GO:0051604 129 96 0,000 0,52585805 0,52723344 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,5295397 0,53069338 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,53681809 0,53775331 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,54041525 0,54112106 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,54041525 0,54088559 ! divalent metal ion transport GO:0070838 171 100 0,000 0,54041525 0,54065032 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,54041525 0,54041525