pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6937-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of cell migration GO:0030335 36 36 5,000 4,894E-07 9,02E-04 ! positive regulation of cell motion GO:0051272 39 39 5,000 8,037E-07 7,406E-04 ! regulation of cell migration GO:0030334 71 71 6,000 2,054E-06 1,262E-03 ! regulation of locomotion GO:0040012 79 79 6,000 4,246E-06 1,956E-03 ! regulation of cell motion GO:0051270 79 79 6,000 4,246E-06 1,565E-03 ! response to hypoxia GO:0001666 53 53 5,000 5,154E-06 1,583E-03 ! response to oxygen levels GO:0070482 55 54 5,000 5,76E-06 1,517E-03 ! positive regulation of glucose metabolic process GO:0010907 5 5 2,000 5,919E-06 1,364E-03 ! positive regulation of catabolic process GO:0009896 16 16 3,000 8,223E-06 1,684E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 4,000 1,041E-05 1,918E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 2,000 1,177E-05 1,971E-03 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! blood vessel development GO:0001568 95 94 6,000 1,357E-05 2,084E-03 ! vasculature development GO:0001944 97 96 6,000 1,559E-05 2,21E-03 ! placenta development GO:0001890 19 19 3,000 1,718E-05 2,261E-03 ! positive regulation of cellular catabolic process GO:0031331 7 7 2,000 2,046E-05 2,514E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 2,000 2,046E-05 2,357E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! G1/S transition of mitotic cell cycle GO:0000082 21 21 3,000 2,619E-05 2,839E-03 ! negative regulation of protein transport GO:0051224 21 21 3,000 2,619E-05 2,681E-03 ! negative regulation of bone remodeling GO:0046851 8 8 2,000 3,254E-05 3,157E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 2,000 3,254E-05 2,999E-03 ! cytoplasmic sequestering of protein GO:0051220 8 8 2,000 3,254E-05 2,856E-03 ! regulation of catabolic process GO:0009894 48 47 4,000 4,546E-05 3,808E-03 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 2,000 4,852E-05 3,888E-03 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 2,000 4,852E-05 3,726E-03 ! negative regulation of tissue remodeling GO:0034104 9 9 2,000 4,852E-05 3,577E-03 ! defense response to virus GO:0051607 9 9 2,000 4,852E-05 3,439E-03 ! regulation of intracellular protein transport GO:0033157 25 25 3,000 5,395E-05 3,683E-03 ! skeletal muscle tissue development GO:0007519 50 49 4,000 5,577E-05 3,671E-03 GO:0060538|skeletal muscle organ development, ! cell cycle arrest GO:0007050 49 49 4,000 5,577E-05 3,544E-03 ! positive regulation of MAP kinase activity GO:0043406 50 49 4,000 5,577E-05 3,426E-03 ! interphase of mitotic cell cycle GO:0051329 52 51 4,000 6,781E-05 4,031E-03 GO:0051325|interphase, ! regulation of glucose metabolic process GO:0010906 10 10 2,000 6,889E-05 3,968E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 2,000 6,889E-05 3,847E-03 ! myoblast differentiation GO:0045445 10 10 2,000 6,889E-05 3,734E-03 ! negative regulation of homeostatic process GO:0032845 10 10 2,000 6,889E-05 3,628E-03 ! blood vessel morphogenesis GO:0048514 84 83 5,000 6,947E-05 3,556E-03 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 3,000 7,39E-05 3,681E-03 ! positive regulation of protein kinase activity GO:0045860 89 86 5,000 8,483E-05 4,114E-03 ! protein amino acid autophosphorylation GO:0046777 28 28 3,000 8,566E-05 4,048E-03 ! heart development GO:0007507 90 87 5,000 9,051E-05 4,17E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 9,415E-05 4,232E-03 ! regulation of monooxygenase activity GO:0032768 11 11 2,000 9,415E-05 4,131E-03 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 2,000 9,415E-05 4,035E-03 GO:0006109|regulation of carbohydrate metabolic process, ! positive regulation of transferase activity GO:0051347 91 88 5,000 9,649E-05 4,042E-03 GO:0033674|positive regulation of kinase activity, ! regulation of epithelial cell proliferation GO:0050678 29 29 3,000 9,874E-05 4,044E-03 ! regulation of binding GO:0051098 60 57 4,000 1,162E-04 4,656E-03 ! regulation of protein localization GO:0032880 58 57 4,000 1,162E-04 4,557E-03 ! skeletal muscle fiber development GO:0048741 31 31 3,000 1,291E-04 4,959E-03 ! regulation of intracellular transport GO:0032386 31 31 3,000 1,291E-04 4,857E-03 ! muscle fiber development GO:0048747 32 32 3,000 1,467E-04 5,406E-03 ! vasculogenesis GO:0001570 13 13 2,000 1,612E-04 5,825E-03 ! mitochondrial membrane organization GO:0007006 13 13 2,000 1,612E-04 5,713E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 2,000 1,612E-04 5,606E-03 ! response to corticosteroid stimulus GO:0031960 13 13 2,000 1,612E-04 5,502E-03 GO:0051384|response to glucocorticoid stimulus, ! negative regulation of phosphorylation GO:0042326 13 13 2,000 1,612E-04 5,402E-03 ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 2,000 1,612E-04 5,305E-03 ! negative regulation of intracellular transport GO:0032387 13 13 2,000 1,612E-04 5,212E-03 ! tissue homeostasis GO:0001894 13 13 2,000 1,612E-04 5,122E-03 GO:0048871|multicellular organismal homeostasis, ! angiogenesis GO:0001525 65 64 4,000 2,022E-04 6,315E-03 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 2,039E-04 6,264E-03 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 2,000 2,039E-04 6,161E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of MAP kinase activity GO:0043405 67 66 4,000 2,339E-04 6,952E-03 ! striated muscle tissue development GO:0014706 69 67 4,000 2,511E-04 7,345E-03 ! regulation of transcription factor import into nucleus GO:0042990 15 15 2,000 2,533E-04 7,296E-03 ! negative regulation of growth GO:0045926 37 37 3,000 2,609E-04 7,397E-03 ! regulation of mitotic cell cycle GO:0007346 72 69 4,000 2,884E-04 8,053E-03 ! regulation of homeostatic process GO:0032844 38 38 3,000 2,897E-04 7,969E-03 ! muscle tissue development GO:0060537 72 70 4,000 3,086E-04 8,363E-03 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 2,000 3,74E-04 9,991E-03 ! tissue remodeling GO:0048771 17 17 2,000 3,74E-04 9,848E-03 ! regulation of oxidoreductase activity GO:0051341 17 17 2,000 3,74E-04 9,709E-03 ! regulation of cellular catabolic process GO:0031329 18 18 2,000 4,461E-04 0,01141925 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 2,000 4,461E-04 0,01126282 ! negative regulation of DNA binding GO:0043392 19 18 2,000 4,461E-04 0,01111062 ! regulation of endothelial cell proliferation GO:0001936 19 19 2,000 5,265E-04 0,0129388 ! multicellular organismal metabolic process GO:0044236 19 19 2,000 5,265E-04 0,01276855 ! regulation of protein stability GO:0031647 19 19 2,000 5,265E-04 0,01260272 ! regulation of DNA binding GO:0051101 47 45 3,000 5,592E-04 0,01321342 ! regulation of membrane potential GO:0042391 46 46 3,000 6,086E-04 0,01419781 ! negative regulation of binding GO:0051100 21 20 2,000 6,157E-04 0,01418399 ! hemoglobin biosynthetic process GO:0042541 5 5 1,000 7,111E-04 0,01618052 ! metencephalon development GO:0022037 5 5 1,000 7,111E-04 0,0159832 ! mRNA stabilization GO:0048255 5 5 1,000 7,111E-04 0,01579063 GO:0043489|RNA stabilization, ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 7,111E-04 0,01560265 ! heart looping GO:0001947 5 5 1,000 7,111E-04 0,01541909 ! pituitary gland development GO:0021983 5 5 1,000 7,111E-04 0,0152398 ! vesicle fusion GO:0006906 5 5 1,000 7,111E-04 0,01506463 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 7,111E-04 0,01489344 ! receptor clustering GO:0043113 5 5 1,000 7,111E-04 0,0147261 ! fear response GO:0042596 5 5 1,000 7,111E-04 0,01456247 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 7,111E-04 0,01440245 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 1,000 7,111E-04 0,0142459 ! protein heterooligomerization GO:0051291 5 5 1,000 7,111E-04 0,01409272 ! response to UV-B GO:0010224 5 5 1,000 7,111E-04 0,01394279 ! decidualization GO:0046697 5 5 1,000 7,111E-04 0,01379603 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 7,111E-04 0,01365232 ! positive regulation of monooxygenase activity GO:0032770 5 5 1,000 7,111E-04 0,01351157 ! cellular pigmentation GO:0033059 5 5 1,000 7,111E-04 0,0133737 ! T cell lineage commitment GO:0002360 5 5 1,000 7,111E-04 0,01323861 ! regulation of hormone metabolic process GO:0032350 5 5 1,000 7,111E-04 0,01310623 ! cellular response to nutrient GO:0031670 5 5 1,000 7,111E-04 0,01297646 ! peptidyl-lysine modification GO:0018205 5 5 1,000 7,111E-04 0,01284924 ! positive regulation of erythrocyte differentiation GO:0045648 5 5 1,000 7,111E-04 0,01272449 ! oocyte differentiation GO:0009994 5 5 1,000 7,111E-04 0,01260214 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 7,111E-04 0,01248212 ! spleen development GO:0048536 5 5 1,000 7,111E-04 0,01236436 ! blastocyst formation GO:0001825 5 5 1,000 7,111E-04 0,01224881 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 7,111E-04 0,01213539 ! response to nicotine GO:0035094 5 5 1,000 7,111E-04 0,01202406 ! regulation of protein import into nucleus GO:0042306 21 21 2,000 7,139E-04 0,01196178 ! actin filament organization GO:0007015 50 48 3,000 7,165E-04 0,01189611 ! gland development GO:0048732 51 49 3,000 7,752E-04 0,01275631 ! response to nutrient GO:0007584 49 49 3,000 7,752E-04 0,01264342 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 4,000 7,998E-04 0,01292967 ! maintenance of protein location in cell GO:0032507 23 22 2,000 8,216E-04 0,01316781 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 2,000 8,216E-04 0,01305429 ! negative regulation of transport GO:0051051 51 50 3,000 8,373E-04 0,01318868 ! anatomical structure homeostasis GO:0060249 51 50 3,000 8,373E-04 0,01307691 ! mitotic cell cycle checkpoint GO:0007093 24 23 2,000 9,392E-04 0,01454511 ! positive regulation of growth GO:0045927 23 23 2,000 9,392E-04 0,0144239 ! cell fate commitment GO:0045165 52 52 3,000 9,718E-04 0,01480136 ! brain development GO:0007420 91 90 4,000 9,833E-04 0,01485397 ! negative regulation of cell cycle GO:0045786 92 91 4,000 1,034E-03 0,01548843 ! regulation of protein transport GO:0051223 53 53 3,000 1,044E-03 0,0155231 GO:0070201|regulation of establishment of protein localization, ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 1,061E-03 0,01564073 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 1,061E-03 0,0155166 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 1,061E-03 0,01539442 GO:0050927|positive regulation of positive chemotaxis, ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 1,000 1,061E-03 0,01527415 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 1,000 1,061E-03 0,01515575 ! oligodendrocyte differentiation GO:0048709 6 6 1,000 1,061E-03 0,01503916 ! focal adhesion formation GO:0048041 7 6 1,000 1,061E-03 0,01492436 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 1,061E-03 0,0148113 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 1,061E-03 0,01469994 ! peptidyl-serine phosphorylation GO:0018105 6 6 1,000 1,061E-03 0,01459023 ! negative regulation of ossification GO:0030279 6 6 1,000 1,061E-03 0,01448216 ! regulation of bone resorption GO:0045124 6 6 1,000 1,061E-03 0,01437567 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 1,000 1,061E-03 0,01427074 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 1,061E-03 0,01416733 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 1,061E-03 0,01406541 ! diencephalon development GO:0021536 6 6 1,000 1,061E-03 0,01396494 ! thymus development GO:0048538 6 6 1,000 1,061E-03 0,0138659 ! maternal placenta development GO:0001893 6 6 1,000 1,061E-03 0,01376825 ! regulation of embryonic development GO:0045995 6 6 1,000 1,061E-03 0,01367197 ! localization within membrane GO:0051668 6 6 1,000 1,061E-03 0,01357702 ! mitochondrial transport GO:0006839 24 24 2,000 1,067E-03 0,01355949 ! glucose homeostasis GO:0042593 24 24 2,000 1,067E-03 0,01346662 GO:0033500|carbohydrate homeostasis, ! T cell differentiation GO:0030217 24 24 2,000 1,067E-03 0,01337501 ! maintenance of protein location GO:0045185 25 24 2,000 1,067E-03 0,01328464 ! androgen receptor signaling pathway GO:0030521 24 24 2,000 1,067E-03 0,01319548 ! regulation of cell adhesion GO:0030155 56 55 3,000 1,201E-03 0,01475684 ! regulation of gene-specific transcription GO:0032583 25 25 2,000 1,205E-03 0,01470646 ! endosome transport GO:0016197 25 25 2,000 1,205E-03 0,01460971 ! heart morphogenesis GO:0003007 25 25 2,000 1,205E-03 0,01451422 ! regulation of cell growth GO:0001558 97 96 4,000 1,315E-03 0,01573799 ! negative regulation of cell migration GO:0030336 26 26 2,000 1,354E-03 0,01609742 ! germ cell development GO:0007281 27 26 2,000 1,354E-03 0,01599423 ! maintenance of location in cell GO:0051651 27 26 2,000 1,354E-03 0,01589235 ! posttranscriptional regulation of gene expression GO:0010608 98 98 4,000 1,442E-03 0,016822 ! regulation of chemokine production GO:0032642 7 7 1,000 1,477E-03 0,01711976 ! hair follicle morphogenesis GO:0031069 7 7 1,000 1,477E-03 0,01701276 ! axis specification GO:0009798 7 7 1,000 1,477E-03 0,01690709 ! digestive system development GO:0055123 7 7 1,000 1,477E-03 0,01680272 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 1,000 1,477E-03 0,01669964 ! regulation of mRNA processing GO:0050684 7 7 1,000 1,477E-03 0,01659781 ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 1,477E-03 0,01649722 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 1,477E-03 0,01639784 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 1,477E-03 0,01629965 ! response to gamma radiation GO:0010332 8 7 1,000 1,477E-03 0,01620263 ! regulation of mRNA stability GO:0043488 7 7 1,000 1,477E-03 0,01610675 ! negative regulation of T cell activation GO:0050868 7 7 1,000 1,477E-03 0,01601201 ! mesenchymal cell development GO:0014031 29 27 2,000 1,514E-03 0,01631557 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! peptidyl-amino acid modification GO:0018193 61 59 3,000 1,562E-03 0,01674194 ! muscle organ development GO:0007517 102 100 4,000 1,578E-03 0,01681169 ! cartilage development GO:0051216 29 28 2,000 1,685E-03 0,0178495 ! response to UV GO:0009411 29 29 2,000 1,868E-03 0,01967531 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 1,958E-03 0,02050793 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 1,000 1,958E-03 0,02039206 ! organelle fusion GO:0048284 8 8 1,000 1,958E-03 0,0202775 ! T cell selection GO:0045058 8 8 1,000 1,958E-03 0,02016422 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 1,000 1,958E-03 0,0200522 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 1,958E-03 0,01994141 ! sex determination GO:0007530 8 8 1,000 1,958E-03 0,01983184 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 1,958E-03 0,01972347 ! alpha-beta T cell activation GO:0046631 8 8 1,000 1,958E-03 0,01961628 ! T cell homeostasis GO:0043029 8 8 1,000 1,958E-03 0,01951025 ! peptidyl-serine modification GO:0018209 8 8 1,000 1,958E-03 0,01940535 ! positive regulation of leukocyte migration GO:0002687 8 8 1,000 1,958E-03 0,01930158 ! regulation of RNA stability GO:0043487 8 8 1,000 1,958E-03 0,01919891 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 1,000 1,958E-03 0,01909733 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 1,958E-03 0,01899682 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 2,063E-03 0,01990876 ! vesicle organization GO:0016050 30 30 2,000 2,063E-03 0,01980507 ! negative regulation of cell motion GO:0051271 31 31 2,000 2,27E-03 0,0216813 ! negative regulation of cell growth GO:0030308 32 32 2,000 2,49E-03 0,02365675 ! maintenance of location GO:0051235 33 32 2,000 2,49E-03 0,02353544 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 2,504E-03 0,02354644 ! response to alkaloid GO:0043279 10 9 1,000 2,504E-03 0,02342692 ! response to ethanol GO:0045471 9 9 1,000 2,504E-03 0,0233086 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 1,000 2,504E-03 0,02319147 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 2,504E-03 0,02307551 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 2,504E-03 0,02296071 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 9 9 1,000 2,504E-03 0,02284704 ! positive regulation of protein import into nucleus GO:0042307 9 9 1,000 2,504E-03 0,0227345 ! T cell differentiation in the thymus GO:0033077 9 9 1,000 2,504E-03 0,02262305 ! histone acetylation GO:0016573 9 9 1,000 2,504E-03 0,0225127 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 1,000 2,504E-03 0,02240341 ! positive regulation of oxidoreductase activity GO:0051353 9 9 1,000 2,504E-03 0,02229518 ! regulation of leukocyte migration GO:0002685 9 9 1,000 2,504E-03 0,02218799 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 2,504E-03 0,02208183 ! negative regulation of cell size GO:0045792 33 33 2,000 2,723E-03 0,02389425 ! response to nutrient levels GO:0031667 69 69 3,000 2,785E-03 0,02432631 ! regulation of angiogenesis GO:0045765 35 34 2,000 2,968E-03 0,02580227 ! regulation of bone remodeling GO:0046850 34 34 2,000 2,968E-03 0,02568113 ! response to metal ion GO:0010038 34 34 2,000 2,968E-03 0,02556112 ! muscle cell differentiation GO:0042692 35 34 2,000 2,968E-03 0,02544224 ! regulation of protein catabolic process GO:0042176 35 34 2,000 2,968E-03 0,02532445 ! response to peptide hormone stimulus GO:0043434 36 34 2,000 2,968E-03 0,02520775 ! negative regulation of signal transduction GO:0009968 71 71 3,000 3,091E-03 0,02612907 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 3,113E-03 0,02619698 ! neuron maturation GO:0042551 10 10 1,000 3,113E-03 0,0260779 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 3,113E-03 0,0259599 ! regulation of survival gene product expression GO:0045884 10 10 1,000 3,113E-03 0,02584296 ! epidermis morphogenesis GO:0048730 10 10 1,000 3,113E-03 0,02572707 ! cell-substrate junction assembly GO:0007044 11 10 1,000 3,113E-03 0,02561222 ! cell structure disassembly during apoptosis GO:0006921 10 10 1,000 3,113E-03 0,02549839 ! neuromuscular junction development GO:0007528 10 10 1,000 3,113E-03 0,02538556 ! regulation of protein binding GO:0043393 11 10 1,000 3,113E-03 0,02527373 ! protein export from nucleus GO:0006611 10 10 1,000 3,113E-03 0,02516288 ! gland morphogenesis GO:0022612 10 10 1,000 3,113E-03 0,025053 ! regulation of erythrocyte differentiation GO:0045646 10 10 1,000 3,113E-03 0,02494408 ! lymphocyte homeostasis GO:0002260 10 10 1,000 3,113E-03 0,02483609 ! epithelial to mesenchymal transition GO:0001837 10 10 1,000 3,113E-03 0,02472904 ! gut development GO:0048565 10 10 1,000 3,113E-03 0,02462291 ! protein stabilization GO:0050821 10 10 1,000 3,113E-03 0,02451768 ! multicellular organism reproduction GO:0032504 36 35 2,000 3,227E-03 0,02530514 GO:0048609|reproductive process in a multicellular organism, ! regulation of tissue remodeling GO:0034103 35 35 2,000 3,227E-03 0,02519791 ! response to steroid hormone stimulus GO:0048545 35 35 2,000 3,227E-03 0,02509159 ! response to extracellular stimulus GO:0009991 72 72 3,000 3,252E-03 0,02518082 ! response to inorganic substance GO:0010035 36 36 2,000 3,499E-03 0,02697943 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 2,000 3,499E-03 0,02686702 ! regulation of mitosis GO:0007088 37 36 2,000 3,499E-03 0,02675554 GO:0051783|regulation of nuclear division, ! female pregnancy GO:0007565 37 36 2,000 3,499E-03 0,02664498 ! response to oxidative stress GO:0006979 76 75 3,000 3,769E-03 0,02858792 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 1,000 3,784E-03 0,02857991 ! signal complex assembly GO:0007172 11 11 1,000 3,784E-03 0,02846326 ! protein amino acid acetylation GO:0006473 11 11 1,000 3,784E-03 0,02834756 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 1,000 3,784E-03 0,02823279 GO:0032388|positive regulation of intracellular transport, ! regulation of viral genome replication GO:0045069 11 11 1,000 3,784E-03 0,02811895 ! activation of MAPKK activity GO:0000186 12 11 1,000 3,784E-03 0,02800602 ! mitotic spindle organization GO:0007052 11 11 1,000 3,784E-03 0,027894 ! apoptotic nuclear changes GO:0030262 11 11 1,000 3,784E-03 0,02778286 ! G1/S transition checkpoint GO:0031575 12 11 1,000 3,784E-03 0,02767262 ! interaction with host GO:0051701 11 11 1,000 3,784E-03 0,02756324 ! oogenesis GO:0048477 11 11 1,000 3,784E-03 0,02745472 ! muscle maintenance GO:0046716 12 11 1,000 3,784E-03 0,02734706 ! hindbrain development GO:0030902 11 11 1,000 3,784E-03 0,02724023 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 3,784E-03 0,02713424 ! regulation of transcription factor activity GO:0051090 38 37 2,000 3,784E-03 0,02703337 GO:0090046|regulation of transcription regulator activity, ! negative regulation of protein kinase activity GO:0006469 37 37 2,000 3,784E-03 0,026929 ! response to drug GO:0042493 37 37 2,000 3,784E-03 0,02682542 ! lung development GO:0030324 38 37 2,000 3,784E-03 0,02672264 ! negative regulation of cell communication GO:0010648 76 76 3,000 3,954E-03 0,0278108 ! negative regulation of kinase activity GO:0033673 38 38 2,000 4,084E-03 0,02861851 ! steroid hormone receptor signaling pathway GO:0030518 38 38 2,000 4,084E-03 0,02851011 ! cell morphogenesis involved in differentiation GO:0000904 82 77 3,000 4,144E-03 0,02881922 ! activation of MAPK activity GO:0000187 39 39 2,000 4,398E-03 0,03046852 ! respiratory tube development GO:0030323 40 39 2,000 4,398E-03 0,03035441 ! respiratory system development GO:0060541 40 39 2,000 4,398E-03 0,03024115 ! lymphocyte differentiation GO:0030098 39 39 2,000 4,398E-03 0,03012872 ! limb development GO:0060173 39 39 2,000 4,398E-03 0,03001714 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! positive regulation of protein catabolic process GO:0045732 12 12 1,000 4,516E-03 0,03070927 ! positive regulation of angiogenesis GO:0045766 12 12 1,000 4,516E-03 0,03059637 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 1,000 4,516E-03 0,03048429 ! collagen metabolic process GO:0032963 12 12 1,000 4,516E-03 0,03037303 ! hindlimb morphogenesis GO:0035137 12 12 1,000 4,516E-03 0,03026259 ! male gonad development GO:0008584 12 12 1,000 4,516E-03 0,03015294 ! renal system process GO:0003014 12 12 1,000 4,516E-03 0,03004408 ! cell fate determination GO:0001709 12 12 1,000 4,516E-03 0,02993601 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 4,516E-03 0,02982871 ! somitogenesis GO:0001756 13 12 1,000 4,516E-03 0,02972218 ! spermatid differentiation GO:0048515 13 12 1,000 4,516E-03 0,02961641 GO:0007286|spermatid development, ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 1,000 4,516E-03 0,02951139 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 4,516E-03 0,02940711 ! negative regulation of translation GO:0017148 12 12 1,000 4,516E-03 0,02930356 ! DNA catabolic process GO:0006308 41 40 2,000 4,725E-03 0,03055733 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 2,000 4,725E-03 0,03045049 ! negative regulation of transferase activity GO:0051348 40 40 2,000 4,725E-03 0,03034439 ! MAPKKK cascade GO:0000165 82 81 3,000 4,967E-03 0,03178498 ! tube development GO:0035295 83 81 3,000 4,967E-03 0,03167499 ! cell cycle checkpoint GO:0000075 42 41 2,000 5,068E-03 0,03220568 ! positive regulation of DNA replication GO:0045740 14 13 1,000 5,307E-03 0,03361279 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 5,307E-03 0,03349768 ! G2/M transition of mitotic cell cycle GO:0000086 13 13 1,000 5,307E-03 0,03338335 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 1,000 5,307E-03 0,03326981 GO:0019692|deoxyribose phosphate metabolic process, ! regeneration GO:0031099 13 13 1,000 5,307E-03 0,03315703 ! post-embryonic development GO:0009791 14 13 1,000 5,307E-03 0,03304501 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 1,000 5,307E-03 0,03293375 ! receptor metabolic process GO:0043112 14 13 1,000 5,307E-03 0,03282323 ! negative regulation of protein catabolic process GO:0042177 13 13 1,000 5,307E-03 0,03271345 ! ureteric bud development GO:0001657 13 13 1,000 5,307E-03 0,03260441 ! cell aging GO:0007569 13 13 1,000 5,307E-03 0,03249609 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 5,307E-03 0,03238849 ! regulation of viral reproduction GO:0050792 13 13 1,000 5,307E-03 0,03228159 ! positive regulation of locomotion GO:0040017 13 13 1,000 5,307E-03 0,0321754 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! neural crest cell migration GO:0001755 14 13 1,000 5,307E-03 0,03206991 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 5,307E-03 0,03196511 ! regulation of cell-substrate adhesion GO:0010810 14 13 1,000 5,307E-03 0,03186099 GO:0001952|regulation of cell-matrix adhesion, ! response to cytokine stimulus GO:0034097 13 13 1,000 5,307E-03 0,03175754 ! activation of JUN kinase activity GO:0007257 13 13 1,000 5,307E-03 0,03165477 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 1,000 5,307E-03 0,03155265 ! blastocyst development GO:0001824 13 13 1,000 5,307E-03 0,0314512 ! protein tetramerization GO:0051262 13 13 1,000 5,307E-03 0,03135039 ! forebrain development GO:0030900 43 42 2,000 5,425E-03 0,03194048 ! mitochondrion organization GO:0007005 44 43 2,000 5,796E-03 0,03402015 ! regulation of cellular localization GO:0060341 86 85 3,000 5,894E-03 0,03448201 ! positive regulation of cell differentiation GO:0045597 87 85 3,000 5,894E-03 0,03437289 ! cellular iron ion homeostasis GO:0006879 14 14 1,000 6,158E-03 0,03580097 ! protein amino acid acylation GO:0043543 14 14 1,000 6,158E-03 0,03568838 ! hair cycle GO:0042633 14 14 1,000 6,158E-03 0,03557651 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! negative regulation of epithelial cell proliferation GO:0050680 14 14 1,000 6,158E-03 0,03546533 ! multicellular organismal response to stress GO:0033555 14 14 1,000 6,158E-03 0,03535485 ! D-ribose metabolic process GO:0006014 14 14 1,000 6,158E-03 0,03524505 ! regulation of behavior GO:0050795 14 14 1,000 6,158E-03 0,03513593 ! response to organic cyclic substance GO:0014070 15 14 1,000 6,158E-03 0,03502749 ! positive regulation of inflammatory response GO:0050729 14 14 1,000 6,158E-03 0,03491971 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 2,000 7,001E-03 0,03958126 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 2,000 7,001E-03 0,03946022 ! insulin receptor signaling pathway GO:0008286 17 15 1,000 7,066E-03 0,03970444 ! ovarian follicle development GO:0001541 15 15 1,000 7,066E-03 0,03958376 ! deoxyribonucleotide metabolic process GO:0009262 15 15 1,000 7,066E-03 0,03946381 ! response to ionizing radiation GO:0010212 16 15 1,000 7,066E-03 0,03934459 ! leukocyte homeostasis GO:0001776 15 15 1,000 7,066E-03 0,03922608 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 1,000 7,066E-03 0,03910828 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 7,066E-03 0,03899119 GO:0090048|negative regulation of transcription regulator activity, ! negative regulation of cell activation GO:0050866 15 15 1,000 7,066E-03 0,0388748 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 2,000 7,881E-03 0,04323076 ! regulation of cell cycle process GO:0010564 50 48 2,000 7,881E-03 0,04310247 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 8,031E-03 0,0437926 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! segmentation GO:0035282 17 16 1,000 8,031E-03 0,04366342 ! triglyceride metabolic process GO:0006641 16 16 1,000 8,031E-03 0,043535 ! iron ion homeostasis GO:0055072 16 16 1,000 8,031E-03 0,04340733 ! positive regulation of cell development GO:0010720 16 16 1,000 8,031E-03 0,04328041 ! lymphocyte proliferation GO:0046651 16 16 1,000 8,031E-03 0,04315422 ! pentose metabolic process GO:0019321 16 16 1,000 8,031E-03 0,04302877 ! cellular response to nutrient levels GO:0031669 16 16 1,000 8,031E-03 0,04290405 ! regulation of JUN kinase activity GO:0043506 17 16 1,000 8,031E-03 0,04278005 GO:0043507|positive regulation of JUN kinase activity, ! leukocyte differentiation GO:0002521 50 49 2,000 8,345E-03 0,04432183 ! regulation of ligase activity GO:0051340 50 49 2,000 8,345E-03 0,04419447 ! T cell activation GO:0042110 51 50 2,000 8,824E-03 0,04659846 ! transcription initiation GO:0006352 50 50 2,000 8,824E-03 0,04646532 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 9,052E-03 0,04753154 ! myelination GO:0042552 17 17 1,000 9,052E-03 0,04739651 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 1,000 9,052E-03 0,04726224 ! glucose transport GO:0015758 17 17 1,000 9,052E-03 0,04712873 ! cell junction assembly GO:0034329 18 17 1,000 9,052E-03 0,04699598 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 9,052E-03 0,04686397 ! neural crest cell development GO:0014032 19 17 1,000 9,052E-03 0,04673269 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 18 17 1,000 9,052E-03 0,04660216 ! pigmentation GO:0043473 17 17 1,000 9,052E-03 0,04647235 ! embryonic organ development GO:0048568 17 17 1,000 9,052E-03 0,04634326 ! response to light stimulus GO:0009416 53 52 2,000 9,83E-03 0,05018616 ! anti-apoptosis GO:0006916 100 99 3,000 0,01002867 0,05105754 ! mononuclear cell proliferation GO:0032943 18 18 1,000 0,01012819 0,05142216 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 1,000 0,01012819 0,05128089 ! hexose transport GO:0008645 18 18 1,000 0,01012819 0,0511404 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 1,000 0,01012819 0,05100067 GO:0055092|sterol homeostasis, ! neutral lipid metabolic process GO:0006638 18 18 1,000 0,01012819 0,0508617 GO:0006639|acylglycerol metabolic process, ! B cell differentiation GO:0030183 18 18 1,000 0,01012819 0,05072349 ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 0,01012819 0,05058603 ! ensheathment of neurons GO:0007272 18 18 1,000 0,01012819 0,05044931 GO:0008366|axon ensheathment, ! negative regulation of catabolic process GO:0009895 18 18 1,000 0,01012819 0,05031333 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 0,01012819 0,05017808 ! response to hormone stimulus GO:0009725 102 100 3,000 0,01038077 0,05129159 ! hemopoiesis GO:0030097 104 100 3,000 0,01038077 0,05115445 ! response to virus GO:0009615 54 54 2,000 0,01090076 0,05357361 ! negative regulation of multicellular organismal process GO:0051241 55 54 2,000 0,01090076 0,05343112 ! glial cell differentiation GO:0010001 19 19 1,000 0,01125779 0,05503477 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 0,01125779 0,05488918 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 0,01125779 0,05474435 ! metanephros development GO:0001656 19 19 1,000 0,01125779 0,05460028 ! cellular response to oxidative stress GO:0034599 19 19 1,000 0,01125779 0,05445698 ! peripheral nervous system development GO:0007422 19 19 1,000 0,01125779 0,05431442 ! dorsal/ventral pattern formation GO:0009953 19 19 1,000 0,01125779 0,05417261 ! regulation of cell shape GO:0008360 21 19 1,000 0,01125779 0,05403153 ! response to heat GO:0009408 19 19 1,000 0,01125779 0,05389119 ! microtubule cytoskeleton organization GO:0000226 55 55 2,000 0,01146036 0,05471877 ! in utero embryonic development GO:0001701 55 55 2,000 0,01146036 0,05457737 ! reproductive developmental process GO:0003006 56 56 2,000 0,01203631 0,05717248 ! regulation of muscle development GO:0048634 21 20 1,000 0,01244025 0,05893926 ! negative regulation of cell adhesion GO:0007162 21 20 1,000 0,01244025 0,05878814 ! organic ether metabolic process GO:0018904 20 20 1,000 0,01244025 0,05863778 GO:0006662|glycerol ether metabolic process, ! nucleus organization GO:0006997 20 20 1,000 0,01244025 0,0584882 ! positive regulation of gene-specific transcription GO:0043193 20 20 1,000 0,01244025 0,05833937 ! chromatin remodeling GO:0006338 20 20 1,000 0,01244025 0,0581913 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 0,01244025 0,05804398 ! female gamete generation GO:0007292 20 20 1,000 0,01244025 0,05789741 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 0,01244025 0,05775157 ! single fertilization GO:0007338 21 20 1,000 0,01244025 0,05760647 ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 0,01367459 0,0631636 ! mammary gland development GO:0030879 23 21 1,000 0,01367459 0,06300569 ! receptor-mediated endocytosis GO:0006898 21 21 1,000 0,01367459 0,06284857 ! regulation of action potential in neuron GO:0019228 21 21 1,000 0,01367459 0,06269223 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 0,01367459 0,06253667 ! cellular response to insulin stimulus GO:0032869 23 21 1,000 0,01367459 0,06238187 ! immune effector process GO:0002252 59 59 2,000 0,01386303 0,06308534 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 0,01495989 0,06790905 GO:0090047|positive regulation of transcription regulator activity, ! RNA export from nucleus GO:0006405 22 22 1,000 0,01495989 0,0677422 ! positive regulation of DNA metabolic process GO:0051054 23 22 1,000 0,01495989 0,06757616 ! sister chromatid segregation GO:0000819 22 22 1,000 0,01495989 0,06741094 ! cell junction organization GO:0034330 23 22 1,000 0,01495989 0,06724652 ! ovulation cycle process GO:0022602 22 22 1,000 0,01495989 0,06708291 ! spindle organization GO:0007051 22 22 1,000 0,01495989 0,06692008 ! male sex differentiation GO:0046661 22 22 1,000 0,01495989 0,06675805 ! cytokine production GO:0001816 22 22 1,000 0,01495989 0,0665968 ! cytokinesis GO:0000910 23 22 1,000 0,01495989 0,06643632 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 1,000 0,01495989 0,06627662 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 2,000 0,01516388 0,06701927 ! axonogenesis GO:0007409 66 62 2,000 0,01583939 0,06983731 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,0162952 0,07167553 ! response to estrogen stimulus GO:0043627 23 23 1,000 0,0162952 0,07150487 ! endocrine system development GO:0035270 23 23 1,000 0,0162952 0,07133503 ! female gonad development GO:0008585 23 23 1,000 0,0162952 0,07116599 ! lipid homeostasis GO:0055088 23 23 1,000 0,0162952 0,07099775 ! calcium-mediated signaling GO:0019722 23 23 1,000 0,0162952 0,0708303 ! regulation of JNK cascade GO:0046328 25 23 1,000 0,0162952 0,07066364 ! cell projection assembly GO:0030031 25 23 1,000 0,0162952 0,07049776 ! regulation of response to external stimulus GO:0032101 65 64 2,000 0,0172408 0,07441402 ! regulation of action potential GO:0001508 24 24 1,000 0,0176796 0,07612966 ! gliogenesis GO:0042063 24 24 1,000 0,0176796 0,0759522 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 1,000 0,0176796 0,07577557 ! ovulation cycle GO:0042698 24 24 1,000 0,0176796 0,07559975 ! fertilization GO:0009566 25 24 1,000 0,0176796 0,07542475 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,0176796 0,07525056 ! negative regulation of protein metabolic process GO:0051248 66 66 2,000 0,01870964 0,07945131 ! cellular component disassembly GO:0022411 26 25 1,000 0,01911218 0,08097411 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,01911218 0,08078839 GO:0046660|female sex differentiation, ! regulation of T cell proliferation GO:0042129 25 25 1,000 0,01911218 0,08060352 ! positive regulation of DNA binding GO:0043388 26 25 1,000 0,01911218 0,0804195 ! negative regulation of immune system process GO:0002683 25 25 1,000 0,01911218 0,08023631 ! positive regulation of cytokine production GO:0001819 25 25 1,000 0,01911218 0,08005395 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 0,01946943 0,08136544 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! response to radiation GO:0009314 70 68 2,000 0,02024616 0,08442007 ! regulation of cell size GO:0008361 68 68 2,000 0,02024616 0,0842295 ! positive regulation of binding GO:0051099 27 26 1,000 0,02059204 0,08547551 ! positive regulation of defense response GO:0031349 26 26 1,000 0,02059204 0,08528343 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 0,02059204 0,08509221 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 1,000 0,02059204 0,08490185 ! regulation of T cell differentiation GO:0045580 26 26 1,000 0,02059204 0,08471233 ! pigment metabolic process GO:0042440 26 26 1,000 0,02059204 0,08452367 ! response to insulin stimulus GO:0032868 28 26 1,000 0,02059204 0,08433583 ! synapse organization GO:0050808 26 26 1,000 0,02059204 0,08414884 ! regionalization GO:0003002 70 69 2,000 0,02103984 0,08578857 ! cell part morphogenesis GO:0032990 75 70 2,000 0,0218505 0,0888973 ! wound healing GO:0042060 74 70 2,000 0,0218505 0,08870149 ! learning or memory GO:0007611 28 27 1,000 0,0221183 0,08959125 ! cAMP-mediated signaling GO:0019933 27 27 1,000 0,0221183 0,08939478 ! stress-activated protein kinase signaling pathway GO:0031098 28 28 1,000 0,02369007 0,09553786 GO:0007254|JNK cascade, ! carbohydrate transport GO:0008643 28 28 1,000 0,02369007 0,09532927 ! histone modification GO:0016570 28 28 1,000 0,02369007 0,09512158 ! developmental growth GO:0048589 28 28 1,000 0,02369007 0,09491479 ! regulation of mast cell proliferation GO:0070666 28 28 1,000 0,02369007 0,0947089 ! positive regulation of cell cycle GO:0045787 29 29 1,000 0,0253065 0,10095214 ! viral reproductive process GO:0022415 29 29 1,000 0,0253065 0,1007341 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,0253065 0,100517 ! regulation of lymphocyte proliferation GO:0050670 29 29 1,000 0,0253065 0,10030083 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! covalent chromatin modification GO:0016569 29 29 1,000 0,0253065 0,10008559 ! positive regulation of protein transport GO:0051222 29 29 1,000 0,0253065 0,09987128 ! response to reactive oxygen species GO:0000302 31 30 1,000 0,02696674 0,10619593 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 1,000 0,02696674 0,1059695 ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,02696674 0,10574403 GO:0010863|positive regulation of phospholipase C activity, ! response to temperature stimulus GO:0009266 30 30 1,000 0,02696674 0,10551952 ! regulation of ossification GO:0030278 30 30 1,000 0,02696674 0,10529596 ! vascular process in circulatory system GO:0003018 31 30 1,000 0,02696674 0,10507335 ! regulation of inflammatory response GO:0050727 30 30 1,000 0,02696674 0,10485168 ! positive regulation of multicellular organismal process GO:0051240 76 76 2,000 0,02707107 0,10503575 ! membrane fusion GO:0006944 31 31 1,000 0,02866993 0,11100562 ! B cell activation GO:0042113 31 31 1,000 0,02866993 0,1107729 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,02866993 0,11054116 ! aging GO:0007568 32 31 1,000 0,02866993 0,11031039 ! nucleoside metabolic process GO:0009116 31 31 1,000 0,02866993 0,11008057 ! regulation of DNA replication GO:0006275 32 31 1,000 0,02866993 0,10985171 ! regulation of myeloid cell differentiation GO:0045637 32 31 1,000 0,02866993 0,10962381 ! regulation of protein modification process GO:0031399 79 78 2,000 0,02894697 0,11045395 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,03041524 0,11581672 ! cell maturation GO:0048469 32 32 1,000 0,03041524 0,11557792 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 1,000 0,03041524 0,11534011 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,03041524 0,11510327 ! nuclear export GO:0051168 32 32 1,000 0,03041524 0,1148674 ! regulation of lymphocyte differentiation GO:0045619 32 32 1,000 0,03041524 0,1146325 ! kidney development GO:0001822 32 32 1,000 0,03041524 0,11439856 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,03041524 0,11416556 ! neuron projection development GO:0031175 85 80 2,000 0,03089049 0,11571378 ! lymphocyte activation GO:0046649 82 81 2,000 0,03188755 0,11920641 ! regulation of cellular response to stress GO:0080135 35 33 1,000 0,03220186 0,12013772 ! activation of protein kinase activity GO:0032147 35 33 1,000 0,03220186 0,11989502 ! regulation of neuron differentiation GO:0045664 34 33 1,000 0,03220186 0,11965329 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,03220186 0,11941254 ! ear development GO:0043583 34 34 1,000 0,03402898 0,12593455 ! secondary metabolic process GO:0019748 34 34 1,000 0,03402898 0,12568218 ! viral reproduction GO:0016032 34 34 1,000 0,03402898 0,12543081 ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,03589579 0,13204777 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 0,03589579 0,13178473 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,03604364 0,13206447 ! embryonic limb morphogenesis GO:0030326 36 36 1,000 0,0378015 0,13823048 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 0,0378015 0,13795675 GO:0045937|positive regulation of phosphate metabolic process, ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 1,000 0,0378015 0,13768411 ! gonad development GO:0008406 36 36 1,000 0,0378015 0,13741254 ! regulation of lipase activity GO:0060191 36 36 1,000 0,0378015 0,13714205 ! male gamete generation GO:0048232 90 88 2,000 0,03933577 0,14242793 GO:0007283|spermatogenesis, ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 0,03974533 0,14362872 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! ATP synthesis coupled electron transport GO:0042773 37 37 1,000 0,03974533 0,14334765 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! adaptive immune response GO:0002250 37 37 1,000 0,03974533 0,14306767 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 2,000 0,04046623 0,14537868 ! cell-matrix adhesion GO:0007160 39 38 1,000 0,04172652 0,14961475 ! chromosome segregation GO:0007059 38 38 1,000 0,04172652 0,14932423 ! urogenital system development GO:0001655 38 38 1,000 0,04172652 0,14903485 ! RNA elongation GO:0006354 38 38 1,000 0,04172652 0,14874658 ! axon guidance GO:0007411 39 38 1,000 0,04172652 0,14845942 ! rRNA transcription GO:0009303 5 5 0,000 0,04216083 0,14971562 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,04216083 0,1494277 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,04216083 0,1491409 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,04216083 0,14885518 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,04216083 0,14857057 ! reproductive cellular process GO:0048610 5 5 0,000 0,04216083 0,14828703 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,04216083 0,14800458 ! prostate gland development GO:0030850 5 5 0,000 0,04216083 0,14772321 ! water transport GO:0006833 5 5 0,000 0,04216083 0,1474429 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,04216083 0,14716365 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,04216083 0,14688546 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,04216083 0,14660831 ! glycerol metabolic process GO:0006071 5 5 0,000 0,04216083 0,14633222 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,04216083 0,14605715 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,04216083 0,14578313 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,04216083 0,14551012 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,04216083 0,14523814 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,04216083 0,14496718 ! filopodium assembly GO:0046847 7 5 0,000 0,04216083 0,14469722 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,04216083 0,14442826 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,04216083 0,14416031 ! GTP metabolic process GO:0046039 5 5 0,000 0,04216083 0,14389335 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,04216083 0,14362737 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,04216083 0,14336237 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,04216083 0,14309835 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,04216083 0,14283531 ! social behavior GO:0035176 5 5 0,000 0,04216083 0,14257322 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,04216083 0,1423121 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,04216083 0,14205193 ! memory GO:0007613 5 5 0,000 0,04216083 0,14179271 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,04216083 0,14153444 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,04216083 0,1412771 ! response to lipid GO:0033993 5 5 0,000 0,04216083 0,1410207 ! erythrocyte maturation GO:0043249 5 5 0,000 0,04216083 0,14076523 ! hippocampus development GO:0021766 6 5 0,000 0,04216083 0,14051068 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,04216083 0,14025705 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,04216083 0,14000434 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,04216083 0,13975253 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,04216083 0,13950163 ! mechanosensory behavior GO:0007638 5 5 0,000 0,04216083 0,13925162 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,04216083 0,13900252 ! response to interferon-gamma GO:0034341 5 5 0,000 0,04216083 0,1387543 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,04216083 0,13850696 ! endocrine pancreas development GO:0031018 5 5 0,000 0,04216083 0,13826051 ! pH reduction GO:0045851 5 5 0,000 0,04216083 0,13801493 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,04216083 0,13777022 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,04216083 0,13752638 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,04216083 0,1372834 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,04216083 0,13704128 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,04216083 0,13680001 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,04216083 0,13655959 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,04216083 0,13632001 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,04216083 0,13608127 ! adrenal gland development GO:0030325 5 5 0,000 0,04216083 0,13584337 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,04216083 0,13560629 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,04216083 0,13537005 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,04216083 0,13513462 ! astrocyte differentiation GO:0048708 5 5 0,000 0,04216083 0,13490001 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,04216083 0,13466622 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,04216083 0,13443323 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,04216083 0,13420105 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,04216083 0,13396967 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,04216083 0,13373908 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,04216083 0,13350929 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,04216083 0,13328029 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,04216083 0,13305207 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,04216083 0,13282463 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,04216083 0,13259796 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,04216083 0,13237207 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,04216083 0,13214695 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,04216083 0,13192259 ! response to ATP GO:0033198 5 5 0,000 0,04216083 0,13169899 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,04216083 0,13147615 ! regulation of appetite GO:0032098 5 5 0,000 0,04216083 0,13125406 GO:0032095|regulation of response to food, ! paraxial mesoderm development GO:0048339 5 5 0,000 0,04216083 0,13103273 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,04216083 0,13081213 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,04216083 0,13059228 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04216083 0,13037316 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,04216083 0,13015478 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,04216083 0,12993713 ! retinol metabolic process GO:0042572 5 5 0,000 0,04216083 0,12972021 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,04216083 0,12950401 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,04216083 0,12928853 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,04216083 0,12907376 ! parturition GO:0007567 5 5 0,000 0,04216083 0,12885971 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,04216083 0,12864637 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,04216083 0,12843373 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,04216083 0,12822179 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,04216083 0,12801055 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,04216083 0,12780001 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,04216083 0,12759016 ! oligodendrocyte development GO:0014003 5 5 0,000 0,04216083 0,12738099 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,04216083 0,12717251 ! activated T cell proliferation GO:0050798 5 5 0,000 0,04216083 0,12696472 ! interaction with symbiont GO:0051702 5 5 0,000 0,04216083 0,1267576 ! cellular extravasation GO:0045123 5 5 0,000 0,04216083 0,12655115 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,04216083 0,12634538 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,04216083 0,12614027 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,04216083 0,12593583 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,04216083 0,12573205 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,04216083 0,12552893 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,04216083 0,12532646 ! response to amine stimulus GO:0014075 5 5 0,000 0,04216083 0,12512465 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,04216083 0,12492348 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,04216083 0,12472296 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,04216083 0,12452309 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,04216083 0,12432385 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,04216083 0,12412525 ! neuron recognition GO:0008038 5 5 0,000 0,04216083 0,12392728 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,04216083 0,12372995 ! hair follicle maturation GO:0048820 5 5 0,000 0,04216083 0,12353324 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,04216083 0,12333715 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,04216083 0,12314169 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,04216083 0,12294685 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,04216083 0,12275262 ! postreplication repair GO:0006301 5 5 0,000 0,04216083 0,122559 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,04216083 0,12236599 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,04216083 0,12217359 ! DNA methylation GO:0006306 5 5 0,000 0,04216083 0,1219818 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04216083 0,12179061 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,04216083 0,12160001 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,04216083 0,12141001 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,04216083 0,1212206 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,04216083 0,12103179 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,04216083 0,12084356 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,04216083 0,12065591 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,04216083 0,12046885 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,04216083 0,12028236 ! sterol catabolic process GO:0016127 5 5 0,000 0,04216083 0,12009645 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,04216083 0,11991112 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,04216083 0,11972636 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,04216083 0,11954216 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,04216083 0,11935854 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,04216083 0,11917547 ! zymogen activation GO:0031638 5 5 0,000 0,04216083 0,11899297 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,04216083 0,11881102 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,04216083 0,11862963 GO:0002820|negative regulation of adaptive immune response, ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 0,04216083 0,11844879 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,04216083 0,1182685 ! nucleosome positioning GO:0016584 5 5 0,000 0,04216083 0,11808876 ! regulation of isotype switching GO:0045191 5 5 0,000 0,04216083 0,11790957 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,04216083 0,11773092 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,04216083 0,11755281 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,04216083 0,11737524 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,04216083 0,1171982 ! NADPH regeneration GO:0006740 5 5 0,000 0,04216083 0,1170217 GO:0006098|pentose-phosphate shunt, ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,04216083 0,11684572 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,04216083 0,11667028 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,04216083 0,11649536 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,04216083 0,11632097 ! sarcomere organization GO:0045214 5 5 0,000 0,04216083 0,11614709 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,04216083 0,11597374 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,04216083 0,1158009 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,04216083 0,11562858 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,04216083 0,11545677 GO:0045622|regulation of T-helper cell differentiation, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,04216083 0,11528547 ! male genitalia development GO:0030539 5 5 0,000 0,04216083 0,11511468 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,04216083 0,11494439 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,04216083 0,1147746 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,04216083 0,11460532 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,04216083 0,11443653 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,04216083 0,11426824 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,04216083 0,11410045 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,04216083 0,11393315 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,04216083 0,11376633 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,04216083 0,11360001 ! ATP catabolic process GO:0006200 5 5 0,000 0,04216083 0,11343417 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04216083 0,11326881 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,04216083 0,11310394 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,04216083 0,11293954 ! embryonic gut development GO:0048566 5 5 0,000 0,04216083 0,11277563 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,04216083 0,11261218 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,04216083 0,11244921 ! activation of innate immune response GO:0002218 5 5 0,000 0,04216083 0,11228671 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,04216083 0,11212468 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,04216083 0,11196312 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,04216083 0,11180202 ! muscle adaptation GO:0043500 5 5 0,000 0,04216083 0,11164139 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,04216083 0,11148121 ! embryonic heart tube development GO:0035050 5 5 0,000 0,04216083 0,1113215 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,04216083 0,11116224 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,04216083 0,11100344 ! defense response to fungus GO:0050832 5 5 0,000 0,04216083 0,11084509 ! lysogeny GO:0030069 5 5 0,000 0,04216083 0,11068719 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,04216083 0,11052974 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,04216083 0,11037274 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,04216083 0,11021618 ! establishment of cell polarity GO:0030010 5 5 0,000 0,04216083 0,11006007 ! mitochondrion localization GO:0051646 5 5 0,000 0,04216083 0,10990439 ! nucleus localization GO:0051647 5 5 0,000 0,04216083 0,10974916 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,04216083 0,10959437 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 2,000 0,04277645 0,11103802 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,04374431 0,11339066 ! nucleotide-excision repair GO:0006289 40 39 1,000 0,04374431 0,1132314 ! regulation of MAPKKK cascade GO:0043408 41 39 1,000 0,04374431 0,11307259 ! developmental maturation GO:0021700 39 39 1,000 0,04374431 0,11291423 ! protein oligomerization GO:0051259 39 39 1,000 0,04374431 0,1127563 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,04579794 0,11788491 ! regulation of response to stress GO:0080134 97 94 2,000 0,04636409 0,11917575 ! pattern specification process GO:0007389 96 94 2,000 0,04636409 0,11900977 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,04788667 0,12274705 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! respiratory electron transport chain GO:0022904 43 42 1,000 0,05000978 0,12801114 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,05000978 0,12783359 ! cell-substrate adhesion GO:0031589 43 42 1,000 0,05000978 0,12765653 ! development of primary sexual characteristics GO:0045137 42 42 1,000 0,05000978 0,12747997 ! protein ubiquitination GO:0016567 43 42 1,000 0,05000978 0,12730389 ! negative regulation of ligase activity GO:0051352 43 42 1,000 0,05000978 0,1271283 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! response to protein stimulus GO:0051789 42 42 1,000 0,05000978 0,12695319 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 1,000 0,05000978 0,12677857 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,05038083 0,12754378 ! axon extension GO:0048675 7 6 0,000 0,05038083 0,12736882 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,05038083 0,12719434 ! tRNA modification GO:0006400 6 6 0,000 0,05038083 0,12702034 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,05038083 0,12684682 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,05038083 0,12667376 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,05038083 0,12650118 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,05038083 0,12632907 ! regulation of S phase GO:0033261 6 6 0,000 0,05038083 0,12615743 ! myotube differentiation GO:0014902 6 6 0,000 0,05038083 0,12598625 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,05038083 0,12581554 ! bone remodeling GO:0046849 6 6 0,000 0,05038083 0,12564529 ! N-glycan processing GO:0006491 6 6 0,000 0,05038083 0,1254755 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,05038083 0,12530617 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,05038083 0,12513729 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,05038083 0,12496887 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,05038083 0,1248009 ! RNA methylation GO:0001510 6 6 0,000 0,05038083 0,12463338 ! cartilage condensation GO:0001502 7 6 0,000 0,05038083 0,12446631 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,05038083 0,12429969 ! succinate metabolic process GO:0006105 7 6 0,000 0,05038083 0,12413352 ! artery development GO:0060840 6 6 0,000 0,05038083 0,12396778 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,05038083 0,12380249 ! bile acid metabolic process GO:0008206 6 6 0,000 0,05038083 0,12363764 ! androgen metabolic process GO:0008209 6 6 0,000 0,05038083 0,12347323 ! estrogen metabolic process GO:0008210 6 6 0,000 0,05038083 0,12330926 ! limbic system development GO:0021761 7 6 0,000 0,05038083 0,12314572 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,05038083 0,12298261 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,05038083 0,12281993 ! pathogenesis GO:0009405 6 6 0,000 0,05038083 0,12265769 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,05038083 0,12249587 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,05038083 0,12233448 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,05038083 0,12217351 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,05038083 0,12201297 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,05038083 0,12185285 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,05038083 0,12169314 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,05038083 0,12153386 ! arginine metabolic process GO:0006525 6 6 0,000 0,05038083 0,12137499 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,05038083 0,12121654 ! glutamate catabolic process GO:0006538 7 6 0,000 0,05038083 0,1210585 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,05038083 0,12090087 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,05038083 0,12074365 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,05038083 0,12058684 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,05038083 0,12043044 ! ER overload response GO:0006983 6 6 0,000 0,05038083 0,12027444 ! V(D)J recombination GO:0033151 6 6 0,000 0,05038083 0,12011885 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,05038083 0,11996366 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,05038083 0,11980886 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,05038083 0,11965447 ! regulation of heart rate GO:0002027 6 6 0,000 0,05038083 0,11950048 ! lipid digestion GO:0044241 6 6 0,000 0,05038083 0,11934688 ! asymmetric protein localization GO:0008105 6 6 0,000 0,05038083 0,11919367 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,05038083 0,11904086 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,05038083 0,11888844 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,05038083 0,11873641 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,05038083 0,11858476 ! ruffle organization GO:0031529 6 6 0,000 0,05038083 0,11843351 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,05038083 0,11828264 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,05038083 0,11813215 ! neutral amino acid transport GO:0015804 6 6 0,000 0,05038083 0,11798204 ! L-amino acid transport GO:0015807 6 6 0,000 0,05038083 0,11783232 ! bone mineralization GO:0030282 6 6 0,000 0,05038083 0,11768298 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,05038083 0,11753401 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,05038083 0,11738542 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,05038083 0,11723721 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,05038083 0,11708937 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 0,05038083 0,1169419 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,05038083 0,1167948 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,05038083 0,11664808 ! regulation of organ growth GO:0046620 6 6 0,000 0,05038083 0,11650172 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,05038083 0,11635573 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,05038083 0,1162101 ! response to dsRNA GO:0043331 6 6 0,000 0,05038083 0,11606484 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,05038083 0,11591994 ! genitalia development GO:0048806 6 6 0,000 0,05038083 0,1157754 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,05038083 0,11563122 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,05038083 0,1154874 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,05038083 0,11534394 ! multicellular organismal aging GO:0010259 6 6 0,000 0,05038083 0,11520083 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,05038083 0,11505808 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,05038083 0,11491568 ! erythrocyte development GO:0048821 6 6 0,000 0,05038083 0,11477363 ! renal water homeostasis GO:0003091 6 6 0,000 0,05038083 0,11463194 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,05038083 0,11449059 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,05038083 0,11434959 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,05038083 0,11420894 ! ribosome assembly GO:0042255 6 6 0,000 0,05038083 0,11406864 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,05038083 0,11392867 ! fucose catabolic process GO:0019317 6 6 0,000 0,05038083 0,11378906 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,05038083 0,11364978 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,05038083 0,11351084 ! regulation of lipid transport GO:0032368 6 6 0,000 0,05038083 0,11337225 ! regulation of cell division GO:0051302 6 6 0,000 0,05038083 0,11323399 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,05038083 0,11309606 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,05038083 0,11295848 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,05038083 0,11282123 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,05038083 0,11268431 ! neuroblast proliferation GO:0007405 6 6 0,000 0,05038083 0,11254772 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,05038083 0,11241146 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,05038083 0,11227554 ! regulation of glucose transport GO:0010827 6 6 0,000 0,05038083 0,11213994 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,05038083 0,11200467 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,05038083 0,11186972 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,05038083 0,1117351 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,05038083 0,1116008 ! lymph node development GO:0048535 6 6 0,000 0,05038083 0,11146683 ! organic cation transport GO:0015695 6 6 0,000 0,05038083 0,11133318 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,05038083 0,11119984 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,05038083 0,11106683 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,05038083 0,11093413 ! sperm-egg recognition GO:0035036 7 6 0,000 0,05038083 0,11080175 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,05038083 0,11066969 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,05038083 0,11053794 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,05038083 0,1104065 ! alditol metabolic process GO:0019400 6 6 0,000 0,05038083 0,11027538 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,05038083 0,11014457 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,05038083 0,11001406 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,05038083 0,10988387 ! blood circulation GO:0008015 99 98 2,000 0,05137307 0,11191556 GO:0003013|circulatory system process, ! reproductive structure development GO:0048608 43 43 1,000 0,05216654 0,11350995 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 1,000 0,05216654 0,1133761 ! homeostasis of number of cells GO:0048872 44 43 1,000 0,05216654 0,11324256 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,05216654 0,11310933 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 2,000 0,05397284 0,1168883 ! response to other organism GO:0051707 101 100 2,000 0,05397284 0,11675111 ! humoral immune response GO:0006959 44 44 1,000 0,05435624 0,11744262 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 1,000 0,05435624 0,1173051 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,05435624 0,1171679 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 0,05657819 0,12181495 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 1,000 0,05657819 0,12167281 ! Wnt receptor signaling pathway GO:0016055 46 45 1,000 0,05657819 0,121531 ! respiratory burst GO:0045730 7 7 0,000 0,05853147 0,12558033 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,05853147 0,12543431 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,05853147 0,12528863 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,05853147 0,12514328 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,05853147 0,12499827 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,05853147 0,1248536 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,05853147 0,12470926 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,05853147 0,12456525 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,05853147 0,12442158 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,05853147 0,12427823 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,05853147 0,12413522 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,05853147 0,12399254 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,05853147 0,12385018 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,05853147 0,12370815 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,05853147 0,12356645 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,05853147 0,12342507 ! visual behavior GO:0007632 7 7 0,000 0,05853147 0,12328401 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,05853147 0,12314327 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,05853147 0,12300286 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,05853147 0,12286276 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,05853147 0,12272299 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,05853147 0,12258353 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,05853147 0,12244439 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,05853147 0,12230556 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,05853147 0,12216705 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,05853147 0,12202885 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,05853147 0,12189097 ! protein targeting to ER GO:0045047 8 7 0,000 0,05853147 0,12175339 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,05853147 0,12161613 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,05853147 0,12147917 ! endoderm development GO:0007492 7 7 0,000 0,05853147 0,12134253 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,05853147 0,12120619 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,05853147 0,12107015 GO:0006688|glycosphingolipid biosynthetic process, ! response to hexose stimulus GO:0009746 7 7 0,000 0,05853147 0,12093443 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,05853147 0,120799 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,05853147 0,12066388 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,05853147 0,12052906 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,05853147 0,12039454 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,05853147 0,12026032 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,05853147 0,1201264 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,05853147 0,11999278 ! response to X-ray GO:0010165 7 7 0,000 0,05853147 0,11985945 ! regulation of intracellular pH GO:0051453 7 7 0,000 0,05853147 0,11972642 ! UV protection GO:0009650 7 7 0,000 0,05853147 0,11959369 ! DNA integration GO:0015074 7 7 0,000 0,05853147 0,11946125 ! myofibril assembly GO:0030239 7 7 0,000 0,05853147 0,1193291 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,05853147 0,11919725 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,05853147 0,11906568 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,05853147 0,11893441 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,05853147 0,11880342 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,05853147 0,11867273 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,05853147 0,11854232 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,05853147 0,11841219 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,05853147 0,11828235 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,05853147 0,1181528 ! axon cargo transport GO:0008088 7 7 0,000 0,05853147 0,11802353 ! eating behavior GO:0042755 7 7 0,000 0,05853147 0,11789454 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,05853147 0,11776584 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,05853147 0,11763741 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,05853147 0,11750927 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,05853147 0,1173814 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,05853147 0,11725381 ! cranial nerve development GO:0021545 7 7 0,000 0,05853147 0,1171265 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,05853147 0,11699947 ! induction of an organ GO:0001759 7 7 0,000 0,05853147 0,11687271 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,05853147 0,11674622 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,05853147 0,11662001 ! autonomic nervous system development GO:0048483 7 7 0,000 0,05853147 0,11649407 ! intracellular lipid transport GO:0032365 7 7 0,000 0,05853147 0,1163684 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,05853147 0,116243 ! platelet activation GO:0030168 8 7 0,000 0,05853147 0,11611788 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,05853147 0,11599302 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,05853147 0,11586843 ! natural killer cell activation GO:0030101 7 7 0,000 0,05853147 0,11574411 ! NADP metabolic process GO:0006739 7 7 0,000 0,05853147 0,11562005 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,05853147 0,11549626 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,05853147 0,11537274 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,05853147 0,11524947 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,05853147 0,11512648 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,05853147 0,11500374 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,05853147 0,11488126 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,05853147 0,11475905 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,05853147 0,1146371 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,05853147 0,1145154 ! cell-cell recognition GO:0009988 8 7 0,000 0,05853147 0,11439396 ! hormone catabolic process GO:0042447 7 7 0,000 0,05853147 0,11427278 ! dopamine metabolic process GO:0042417 7 7 0,000 0,05853147 0,11415186 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,05853147 0,11403119 ! oxygen transport GO:0015671 7 7 0,000 0,05853147 0,11391078 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,05853147 0,11379062 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,05853147 0,11367071 ! regulation of axon extension GO:0030516 7 7 0,000 0,05853147 0,11355106 ! cell killing GO:0001906 7 7 0,000 0,05853147 0,11343166 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,05853147 0,11331251 ! adult feeding behavior GO:0008343 7 7 0,000 0,05853147 0,11319361 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,05853147 0,11307496 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,05853147 0,11295655 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,05853147 0,1128384 ! response to cold GO:0009409 7 7 0,000 0,05853147 0,11272049 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 1,000 0,05883168 0,11318036 ! tube morphogenesis GO:0035239 47 46 1,000 0,05883168 0,11306234 ! positive regulation of ligase activity GO:0051351 47 46 1,000 0,05883168 0,11294457 ! cellular response to hormone stimulus GO:0032870 48 46 1,000 0,05883168 0,11282704 ! sex differentiation GO:0007548 47 47 1,000 0,06111604 0,11708613 ! rhythmic process GO:0048511 47 47 1,000 0,06111604 0,11696454 ! ossification GO:0001503 50 49 1,000 0,06577465 0,12574968 GO:0060348|bone development, ! cellular lipid catabolic process GO:0044242 50 49 1,000 0,06577465 0,12561937 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,06661334 0,12708942 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,06661334 0,12695799 ! positive regulation of translation GO:0045727 8 8 0,000 0,06661334 0,12682684 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,06661334 0,12669596 ! superoxide anion generation GO:0042554 8 8 0,000 0,06661334 0,12656534 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,06661334 0,126435 ! cGMP metabolic process GO:0046068 8 8 0,000 0,06661334 0,12630492 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,06661334 0,12617511 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,06661334 0,12604557 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,06661334 0,12591629 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,06661334 0,12578728 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,06661334 0,12565853 ! zinc ion transport GO:0006829 8 8 0,000 0,06661334 0,12553004 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,06661334 0,12540182 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,06661334 0,12527386 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,06661334 0,12514616 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,06661334 0,12501872 ! lipid localization GO:0010876 8 8 0,000 0,06661334 0,12489154 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,06661334 0,12476461 ! response to cAMP GO:0051591 8 8 0,000 0,06661334 0,12463795 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,06661334 0,12451154 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,06661334 0,12438539 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,06661334 0,12425949 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,06661334 0,12413385 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,06661334 0,12400847 ! sensory perception of taste GO:0050909 8 8 0,000 0,06661334 0,12388333 ! pancreas development GO:0031016 8 8 0,000 0,06661334 0,12375845 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,06661334 0,12363382 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,06661334 0,12350944 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,06661334 0,12338531 ! sperm motility GO:0030317 8 8 0,000 0,06661334 0,12326143 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,06661334 0,12313779 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,06661334 0,12301441 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,06661334 0,12289127 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,06661334 0,12276838 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,06661334 0,12264573 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,06661334 0,12252333 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,06661334 0,12240118 ! Golgi organization GO:0007030 8 8 0,000 0,06661334 0,12227926 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,06661334 0,12215759 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,06661334 0,12203616 ! fructose metabolic process GO:0006000 8 8 0,000 0,06661334 0,12191498 ! mannose metabolic process GO:0006013 9 8 0,000 0,06661334 0,12179403 ! NAD metabolic process GO:0019674 8 8 0,000 0,06661334 0,12167332 ! plasma membrane fusion GO:0045026 8 8 0,000 0,06661334 0,12155285 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,06661334 0,12143262 ! response to fungus GO:0009620 8 8 0,000 0,06661334 0,12131263 ! stem cell differentiation GO:0048863 8 8 0,000 0,06661334 0,12119287 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,06661334 0,12107335 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,06661334 0,12095407 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,06661334 0,12083502 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,06661334 0,1207162 ! regulation of vasodilation GO:0042312 8 8 0,000 0,06661334 0,12059762 ! vasoconstriction GO:0042310 8 8 0,000 0,06661334 0,12047927 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,06661334 0,12036116 ! muscle cell development GO:0055001 8 8 0,000 0,06661334 0,12024327 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,06661334 0,12012562 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,06661334 0,12000819 ! sensory perception of pain GO:0019233 8 8 0,000 0,06661334 0,119891 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,06661334 0,11977403 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,06661334 0,11965729 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,06661334 0,11954078 ! chromatin silencing GO:0006342 8 8 0,000 0,06661334 0,11942449 ! tissue regeneration GO:0042246 8 8 0,000 0,06661334 0,11930844 ! salivary gland development GO:0007431 8 8 0,000 0,06661334 0,1191926 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,06661334 0,11907699 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,06661334 0,11896161 ! water homeostasis GO:0030104 8 8 0,000 0,06661334 0,11884645 ! cofactor transport GO:0051181 8 8 0,000 0,06661334 0,11873151 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,06661334 0,11861679 ! acid secretion GO:0046717 8 8 0,000 0,06661334 0,1185023 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,06661334 0,11838802 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,06661334 0,11827397 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,06661334 0,11816014 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,06661334 0,11804652 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,06661334 0,11793312 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,06661334 0,11781994 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,06661334 0,11770698 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,06661334 0,11759423 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,06661334 0,1174817 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,06661334 0,11736939 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,06661334 0,11725729 ! developmental induction GO:0031128 8 8 0,000 0,06661334 0,1171454 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,06661334 0,11703373 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,06661334 0,11692227 ! actin filament polymerization GO:0030041 9 8 0,000 0,06661334 0,11681102 ! peptide hormone processing GO:0016486 8 8 0,000 0,06661334 0,11669998 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,06661334 0,11658916 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,06661334 0,11647854 ! regulation of defense response GO:0031347 50 50 1,000 0,06814759 0,11904835 ! regulation of DNA metabolic process GO:0051052 51 50 1,000 0,06814759 0,11893562 ! RNA transport GO:0050658 50 50 1,000 0,06814759 0,1188231 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 1,000 0,06814759 0,11871079 ! regulation of neurogenesis GO:0050767 51 50 1,000 0,06814759 0,11859869 ! anterior/posterior pattern formation GO:0009952 51 50 1,000 0,06814759 0,11848681 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,07054875 0,12254604 ! RNA localization GO:0006403 52 52 1,000 0,07297749 0,12664549 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 1,000 0,07297749 0,12652635 ! lactation GO:0007595 10 9 0,000 0,07462699 0,12926461 ! embryonic pattern specification GO:0009880 10 9 0,000 0,07462699 0,12914323 ! positive regulation of cell size GO:0045793 9 9 0,000 0,07462699 0,12902208 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,07462699 0,12890116 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,07462699 0,12878047 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,07462699 0,12866 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,07462699 0,12853976 ! viral genome replication GO:0019079 9 9 0,000 0,07462699 0,12841974 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,07462699 0,12829994 ! copper ion transport GO:0006825 9 9 0,000 0,07462699 0,12818037 ! lipid phosphorylation GO:0046834 9 9 0,000 0,07462699 0,12806102 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,07462699 0,1279419 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,07462699 0,12782299 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,07462699 0,12770431 ! RNA polyadenylation GO:0043631 9 9 0,000 0,07462699 0,12758584 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,07462699 0,1274676 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,07462699 0,12734957 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,07462699 0,12723177 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,07462699 0,12711418 ! phospholipid efflux GO:0033700 9 9 0,000 0,07462699 0,12699681 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,07462699 0,12687965 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,07462699 0,12676271 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,07462699 0,12664599 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,07462699 0,12652948 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,07462699 0,12641318 ! methionine metabolic process GO:0006555 9 9 0,000 0,07462699 0,1262971 ! glutamine metabolic process GO:0006541 9 9 0,000 0,07462699 0,12618123 ! cerebral cortex development GO:0021987 9 9 0,000 0,07462699 0,12606557 ! response to osmotic stress GO:0006970 9 9 0,000 0,07462699 0,12595013 ! pigmentation during development GO:0048066 9 9 0,000 0,07462699 0,12583489 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,07462699 0,12571987 ! central nervous system neuron development GO:0021954 10 9 0,000 0,07462699 0,12560506 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,07462699 0,12549046 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,07462699 0,12537606 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,07462699 0,12526188 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,07462699 0,1251479 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,07462699 0,12503413 ! L-glutamate transport GO:0015813 9 9 0,000 0,07462699 0,12492056 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,07462699 0,12480721 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,07462699 0,12469405 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,07462699 0,12458111 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,07462699 0,12446836 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,07462699 0,12435582 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,07462699 0,12424349 ! DNA replication initiation GO:0006270 9 9 0,000 0,07462699 0,12413135 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,07462699 0,12401942 GO:0006692|prostanoid metabolic process, ! regulation of cellular pH GO:0030641 9 9 0,000 0,07462699 0,12390769 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,07462699 0,12379617 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,07462699 0,12368484 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,07462699 0,12357371 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,07462699 0,12346278 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,07462699 0,12335205 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,07462699 0,12324152 ! collagen catabolic process GO:0030574 9 9 0,000 0,07462699 0,12313119 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,07462699 0,12302106 ! purine base metabolic process GO:0006144 9 9 0,000 0,07462699 0,12291112 ! gas transport GO:0015669 9 9 0,000 0,07462699 0,12280138 ! cholesterol efflux GO:0033344 9 9 0,000 0,07462699 0,12269183 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,07462699 0,12258248 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,07462699 0,12247332 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,07462699 0,12236436 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,07462699 0,12225559 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,07462699 0,12214702 ! actin filament-based movement GO:0030048 9 9 0,000 0,07462699 0,12203863 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,07462699 0,12193044 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 1,000 0,07543318 0,12313848 ! regulation of T cell activation GO:0050863 53 53 1,000 0,07543318 0,12302951 ! protein amino acid dephosphorylation GO:0006470 55 54 1,000 0,07791519 0,12696526 ! protein modification by small protein conjugation or removal GO:0070647 56 55 1,000 0,08042292 0,13093591 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,08257299 0,13431777 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,08257299 0,13419932 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,08257299 0,13408108 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,08257299 0,13396305 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,08257299 0,13384523 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,08257299 0,13372762 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,08257299 0,13361021 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,08257299 0,13349301 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,08257299 0,13337601 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,08257299 0,13325922 ! hormone secretion GO:0046879 10 10 0,000 0,08257299 0,13314263 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,08257299 0,13302625 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,08257299 0,13291007 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inositol metabolic process GO:0006020 10 10 0,000 0,08257299 0,13279409 ! cAMP metabolic process GO:0046058 10 10 0,000 0,08257299 0,13267832 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,08257299 0,13256274 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,08257299 0,13244737 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,08257299 0,1323322 ! glial cell development GO:0021782 10 10 0,000 0,08257299 0,13221723 ! phototransduction GO:0007602 11 10 0,000 0,08257299 0,13210246 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,08257299 0,13198788 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,08257299 0,13187351 ! fat cell differentiation GO:0045444 10 10 0,000 0,08257299 0,13175933 ! centrosome cycle GO:0007098 10 10 0,000 0,08257299 0,13164535 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,08257299 0,13153157 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,08257299 0,13141799 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,08257299 0,1313046 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,08257299 0,1311914 ! protein polyubiquitination GO:0000209 10 10 0,000 0,08257299 0,13107841 ! glutamate metabolic process GO:0006536 11 10 0,000 0,08257299 0,1309656 ! plasma membrane organization GO:0007009 10 10 0,000 0,08257299 0,13085299 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,08257299 0,13074058 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,08257299 0,13062835 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,08257299 0,13051632 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,08257299 0,13040448 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,08257299 0,13029283 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,08257299 0,13018138 ! exocrine system development GO:0035272 10 10 0,000 0,08257299 0,13007011 ! embryo implantation GO:0007566 11 10 0,000 0,08257299 0,12995903 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,08257299 0,12984815 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,08257299 0,12973745 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,08257299 0,12962694 ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,08257299 0,12951662 ! negative regulation of immune response GO:0050777 10 10 0,000 0,08257299 0,12940649 ! cytolysis GO:0019835 10 10 0,000 0,08257299 0,12929654 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,08257299 0,12918678 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,08257299 0,12907721 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,08257299 0,12896782 ! histone deacetylation GO:0016575 10 10 0,000 0,08257299 0,12885862 ! mRNA splice site selection GO:0006376 11 10 0,000 0,08257299 0,1287496 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,08257299 0,12864077 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,08257299 0,12853212 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,08257299 0,12842365 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,08257299 0,12831537 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,08257299 0,12820727 ! regulation of epidermis development GO:0045682 10 10 0,000 0,08257299 0,12809935 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,08257299 0,12799161 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,08257299 0,12788406 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,08257299 0,12777668 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,08257299 0,12766949 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,08257299 0,12756247 ! nerve development GO:0021675 10 10 0,000 0,08257299 0,12745564 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,08257299 0,12734898 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,08257299 0,1272425 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,08257299 0,1271362 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,08257299 0,12703007 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,08257299 0,12692413 ! extracellular structure organization GO:0043062 56 56 1,000 0,08295576 0,12740622 ! regulation of nervous system development GO:0051960 57 56 1,000 0,08295576 0,12730014 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 1,000 0,08551311 0,13111536 ! protein secretion GO:0009306 11 11 0,000 0,09045192 0,13857264 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,09045192 0,13845754 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,09045192 0,13834264 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,09045192 0,13822793 ! negative regulation of defense response GO:0031348 11 11 0,000 0,09045192 0,13811341 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,09045192 0,13799907 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,09045192 0,13788493 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,09045192 0,13777098 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,09045192 0,13765721 ! skin development GO:0043588 11 11 0,000 0,09045192 0,13754363 ! microtubule-based transport GO:0010970 11 11 0,000 0,09045192 0,13743024 ! endothelial cell migration GO:0043542 11 11 0,000 0,09045192 0,13731704 ! peroxisomal transport GO:0043574 11 11 0,000 0,09045192 0,13720402 ! protein amino acid methylation GO:0006479 11 11 0,000 0,09045192 0,13709119 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,09045192 0,13697854 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,09045192 0,13686608 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,09045192 0,1367538 ! T cell proliferation GO:0042098 11 11 0,000 0,09045192 0,13664171 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,09045192 0,1365298 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,09045192 0,13641807 ! spinal cord development GO:0021510 11 11 0,000 0,09045192 0,13630653 ! smooth muscle contraction GO:0006939 11 11 0,000 0,09045192 0,13619517 ! cellular response to starvation GO:0009267 11 11 0,000 0,09045192 0,13608399 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,09045192 0,13597299 ! digestive system process GO:0022600 11 11 0,000 0,09045192 0,13586217 ! fucose metabolic process GO:0006004 11 11 0,000 0,09045192 0,13575153 ! membrane budding GO:0006900 11 11 0,000 0,09045192 0,13564108 ! monoamine transport GO:0015844 11 11 0,000 0,09045192 0,1355308 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,09045192 0,1354207 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,09045192 0,13531078 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,09045192 0,13520104 ! body fluid secretion GO:0007589 11 11 0,000 0,09045192 0,13509148 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,09045192 0,13498209 ! intermediate filament-based process GO:0045103 11 11 0,000 0,09045192 0,13487288 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,09045192 0,13476385 GO:0060415|muscle tissue morphogenesis, ! membrane depolarization GO:0051899 11 11 0,000 0,09045192 0,13465499 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,09045192 0,13454631 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,09045192 0,13443781 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,09045192 0,13432948 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,09045192 0,13422132 ! vitamin transport GO:0051180 11 11 0,000 0,09045192 0,13411334 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,09045192 0,13400553 ! steroid catabolic process GO:0006706 11 11 0,000 0,09045192 0,1338979 ! endocrine process GO:0050886 11 11 0,000 0,09045192 0,13379044 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,09045192 0,13368315 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,09045192 0,13357603 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,09045192 0,13346908 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,09045192 0,13336231 ! dephosphorylation GO:0016311 60 59 1,000 0,09069899 0,13361969 ! regulation of cell development GO:0060284 60 59 1,000 0,09069899 0,13351297 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 1,000 0,09332636 0,13727094 ! cellular respiration GO:0045333 62 61 1,000 0,09597594 0,14105555 ! proteasomal protein catabolic process GO:0010498 62 61 1,000 0,09597594 0,14094315 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! translational initiation GO:0006413 12 12 0,000 0,09826431 0,14418879 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,09826431 0,14407409 ! initiation of viral infection GO:0019059 12 12 0,000 0,09826431 0,14395956 ! iron ion transport GO:0006826 13 12 0,000 0,09826431 0,14384521 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,09826431 0,14373105 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,09826431 0,14361707 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,09826431 0,14350327 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,09826431 0,14338965 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,09826431 0,14327621 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,09826431 0,14316294 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,09826431 0,14304986 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,09826431 0,14293696 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,09826431 0,14282423 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,09826431 0,14271168 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,09826431 0,14259931 ! actomyosin structure organization GO:0031032 12 12 0,000 0,09826431 0,14248712 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,09826431 0,1423751 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,09826431 0,14226326 ! retinoid metabolic process GO:0001523 12 12 0,000 0,09826431 0,14215159 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,09826431 0,1420401 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,09826431 0,14192878 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,09826431 0,14181764 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,09826431 0,14170667 ! acute-phase response GO:0006953 12 12 0,000 0,09826431 0,14159588 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,09826431 0,14148525 ! vacuolar transport GO:0007034 12 12 0,000 0,09826431 0,1413748 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,09826431 0,14126453 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,09826431 0,14115442 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,09826431 0,14104449 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,09826431 0,14093473 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,09826431 0,14082514 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,09826431 0,14071571 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,09826431 0,14060646 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,09826431 0,14049738 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,09826431 0,14038847 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,09826431 0,14027973 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,09826431 0,14017115 ! pallium development GO:0021543 13 12 0,000 0,09826431 0,14006274 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,09826431 0,1399545 ! G1 phase GO:0051318 13 12 0,000 0,09826431 0,13984643 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,09826431 0,13973852 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,09826431 0,13963078 ! detection of light stimulus GO:0009583 13 12 0,000 0,09826431 0,13952321 ! synaptogenesis GO:0007416 12 12 0,000 0,09826431 0,1394158 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,09826431 0,13930856 ! hormone transport GO:0009914 12 12 0,000 0,09826431 0,13920148 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,09826431 0,13909457 ! heme biosynthetic process GO:0006783 12 12 0,000 0,09826431 0,13898782 ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,09826431 0,13888123 ! neural tube closure GO:0001843 13 12 0,000 0,09826431 0,13877481 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,09826431 0,13866855 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,09826431 0,13856245 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,09864716 0,13899596 GO:0060429|epithelium development, ! regulation of lymphocyte activation GO:0051249 62 62 1,000 0,09864716 0,13888977 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,10133947 0,14257148 ! glycerolipid metabolic process GO:0046486 65 64 1,000 0,10405233 0,14627646 ! positive regulation of protein metabolic process GO:0051247 64 64 1,000 0,10405233 0,14616497 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,10601073 0,14880257 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,10601073 0,14868933 ! phenol metabolic process GO:0018958 13 13 0,000 0,10601073 0,14857626 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! gluconeogenesis GO:0006094 13 13 0,000 0,10601073 0,14846336 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,10601073 0,14835063 ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,10601073 0,14823807 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,10601073 0,14812568 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,10601073 0,14801347 ! keratinization GO:0031424 13 13 0,000 0,10601073 0,14790142 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,10601073 0,14778954 ! patterning of blood vessels GO:0001569 13 13 0,000 0,10601073 0,14767783 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,10601073 0,1475663 ! regulation of innate immune response GO:0045088 13 13 0,000 0,10601073 0,14745492 ! negative regulation of DNA replication GO:0008156 13 13 0,000 0,10601073 0,14734372 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,10601073 0,14723269 ! autophagy GO:0006914 13 13 0,000 0,10601073 0,14712182 ! actin filament bundle formation GO:0051017 13 13 0,000 0,10601073 0,14701112 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,10601073 0,14690058 ! response to endoplasmic reticulum stress GO:0034976 13 13 0,000 0,10601073 0,14679021 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,10601073 0,14668001 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,10601073 0,14656997 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,10601073 0,1464601 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,10601073 0,14635039 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,10601073 0,14624085 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,10601073 0,14613147 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,10601073 0,14602225 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,10601073 0,1459132 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,10601073 0,14580431 ! vasodilation GO:0042311 14 13 0,000 0,10601073 0,14569558 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,10601073 0,14558702 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,10601073 0,14547861 GO:0006664|glycolipid metabolic process, ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,10601073 0,14537037 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,10601073 0,14526229 ! immunoglobulin production GO:0002377 13 13 0,000 0,10601073 0,14515437 GO:0002440|production of molecular mediator of immune response, ! cell-cell junction organization GO:0045216 13 13 0,000 0,10601073 0,1450466 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,10601073 0,144939 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,10601073 0,14483156 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,10601073 0,14472428 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,10601073 0,14461715 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,10601073 0,14451019 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,10601073 0,14440338 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,10601073 0,14429673 ! telomere organization GO:0032200 13 13 0,000 0,10601073 0,14419024 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,10601073 0,14408391 ! regulation of amine transport GO:0051952 13 13 0,000 0,10601073 0,14397773 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,10601073 0,14387171 ! nucleoside triphosphate metabolic process GO:0009141 66 66 1,000 0,10953756 0,14854873 ! Golgi vesicle transport GO:0048193 67 67 1,000 0,11230889 0,15219506 ! Ras protein signal transduction GO:0007265 69 67 1,000 0,11230889 0,15208324 ! neuron fate commitment GO:0048663 14 14 0,000 0,11369172 0,15384276 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,11369172 0,15372989 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,11369172 0,15361719 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,11369172 0,15350465 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,11369172 0,15339227 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,11369172 0,15328006 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,11369172 0,15316801 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,11369172 0,15305613 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,11369172 0,15294441 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,11369172 0,15283285 ! vesicle docking GO:0048278 14 14 0,000 0,11369172 0,15272146 ! superoxide metabolic process GO:0006801 15 14 0,000 0,11369172 0,15261023 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,11369172 0,15249916 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,11369172 0,15238825 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,11369172 0,1522775 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,11369172 0,15216692 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,11369172 0,15205649 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,11369172 0,15194622 GO:0033189|response to vitamin A, ! lysosome organization GO:0007040 14 14 0,000 0,11369172 0,15183612 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,11369172 0,15172617 ! peptide transport GO:0015833 14 14 0,000 0,11369172 0,15161638 ! primary neural tube formation GO:0014020 15 14 0,000 0,11369172 0,15150676 ! peptide cross-linking GO:0018149 14 14 0,000 0,11369172 0,15139728 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,11369172 0,15128797 ! base-excision repair GO:0006284 14 14 0,000 0,11369172 0,15117882 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,11369172 0,15106982 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,11369172 0,15096098 ! formation of primary germ layer GO:0001704 14 14 0,000 0,11369172 0,1508523 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,11369172 0,15074377 ! collagen fibril organization GO:0030199 14 14 0,000 0,11369172 0,1506354 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,11369172 0,15052719 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,11369172 0,15041913 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,11369172 0,15031122 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,11369172 0,15020347 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,11369172 0,15009588 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,11369172 0,14998843 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,11369172 0,14988115 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,11369172 0,14977401 ! regulation of translation GO:0006417 69 69 1,000 0,1179064 0,15521535 ! regulation of leukocyte activation GO:0002694 69 69 1,000 0,1179064 0,15510456 ! positive regulation of transport GO:0051050 71 70 1,000 0,12073157 0,15870776 ! growth GO:0040007 70 70 1,000 0,12073157 0,15859464 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,12130783 0,15923812 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,12130783 0,15912479 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,12130783 0,15901161 ! positive regulation of ossification GO:0045778 15 15 0,000 0,12130783 0,1588986 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,12130783 0,15878574 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,12130783 0,15867305 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,12130783 0,15856052 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,12130783 0,15844814 ! response to vitamin GO:0033273 15 15 0,000 0,12130783 0,15833593 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,12130783 0,15822387 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,12130783 0,15811197 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,12130783 0,15800023 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,12130783 0,15788865 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,12130783 0,15777722 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,12130783 0,15766596 ! ER-nuclear signaling pathway GO:0006984 15 15 0,000 0,12130783 0,15755485 ! heme metabolic process GO:0042168 15 15 0,000 0,12130783 0,15744389 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,12130783 0,15733309 ! chromosome condensation GO:0030261 15 15 0,000 0,12130783 0,15722245 ! response to starvation GO:0042594 15 15 0,000 0,12130783 0,15711197 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,12130783 0,15700163 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,12130783 0,15689146 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,12130783 0,15678144 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,12130783 0,15667157 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,12130783 0,15656185 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,12130783 0,15645229 ! phospholipid transport GO:0015914 15 15 0,000 0,12130783 0,15634289 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,12130783 0,15623363 ! glutathione metabolic process GO:0006749 16 15 0,000 0,12130783 0,15612453 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,12130783 0,15601558 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,12130783 0,15590678 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,12130783 0,15579814 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,12130783 0,15568964 ! protein homooligomerization GO:0051260 15 15 0,000 0,12130783 0,1555813 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,12130783 0,15547311 ! oxidative phosphorylation GO:0006119 71 71 1,000 0,1235737 0,15826708 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,1235737 0,15815717 GO:0006874|cellular calcium ion homeostasis, ! regulation of cell activation GO:0050865 71 71 1,000 0,1235737 0,15804742 ! positive regulation of hydrolase activity GO:0051345 72 72 1,000 0,1264323 0,16159135 ! sensory organ development GO:0007423 72 72 1,000 0,1264323 0,16147937 ! regulation of cytokine production GO:0001817 72 72 1,000 0,1264323 0,16136754 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,12885959 0,16435171 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,12885959 0,16423805 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,12885959 0,16412455 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,12885959 0,1640112 ! learning GO:0007612 16 16 0,000 0,12885959 0,16389801 ! circadian rhythm GO:0007623 16 16 0,000 0,12885959 0,16378498 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,12885959 0,1636721 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,12885959 0,16355938 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,12885959 0,16344681 ! vacuole organization GO:0007033 16 16 0,000 0,12885959 0,1633344 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,12885959 0,16322215 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,12885959 0,16311004 ! vesicle targeting GO:0006903 17 16 0,000 0,12885959 0,16299809 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,12885959 0,1628863 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,12885959 0,16277466 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,12885959 0,16266317 ! cell fate specification GO:0001708 16 16 0,000 0,12885959 0,16255183 ! fatty acid transport GO:0015908 16 16 0,000 0,12885959 0,16244064 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,12885959 0,16232961 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,12885959 0,16221873 ! cofactor catabolic process GO:0051187 16 16 0,000 0,12885959 0,162108 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,12885959 0,16199742 ! polyol metabolic process GO:0019751 16 16 0,000 0,12885959 0,161887 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,12885959 0,16177672 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,12885959 0,16166659 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,12885959 0,16155661 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,12885959 0,16144679 GO:0001841|neural tube formation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,12885959 0,16133711 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,12885959 0,16122758 ! regulation of coagulation GO:0050818 17 16 0,000 0,12885959 0,1611182 ! electron transport chain GO:0022900 75 74 1,000 0,132197 0,16517903 ! regulation of fibroblast proliferation GO:0048145 17 17 0,000 0,13634754 0,17024967 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,13634754 0,1701344 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,13634754 0,17001929 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,13634754 0,16990434 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,13634754 0,16978954 ! leukocyte adhesion GO:0007159 17 17 0,000 0,13634754 0,16967489 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,13634754 0,1695604 ! sensory perception of smell GO:0007608 17 17 0,000 0,13634754 0,16944606 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,13634754 0,16933188 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,13634754 0,16921785 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,13634754 0,16910398 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,13634754 0,16899026 ! negative regulation of cell development GO:0010721 18 17 0,000 0,13634754 0,16887669 GO:0050768|negative regulation of neurogenesis, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,13634754 0,16876327 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,13634754 0,16865001 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,13634754 0,1685369 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,13634754 0,16842394 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,13634754 0,16831113 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,13634754 0,16819847 ! adult locomotory behavior GO:0008344 17 17 0,000 0,13634754 0,16808596 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,13634754 0,1679736 ! liver development GO:0001889 17 17 0,000 0,13634754 0,1678614 ! gene silencing GO:0016458 17 17 0,000 0,13634754 0,16774934 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,14095582 0,17330325 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,14377221 0,17664812 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,14377221 0,17653043 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,14377221 0,1764129 ! meiosis I GO:0007127 18 18 0,000 0,14377221 0,17629553 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,14377221 0,17617831 ! membrane docking GO:0022406 18 18 0,000 0,14377221 0,17606125 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,14377221 0,17594434 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,14377221 0,17582759 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 0,000 0,14377221 0,17571099 ! striated muscle contraction GO:0006941 18 18 0,000 0,14377221 0,17559455 ! ceramide metabolic process GO:0006672 18 18 0,000 0,14377221 0,17547826 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,14377221 0,17536213 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,14377221 0,17524615 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,14377221 0,17513032 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,14377221 0,17501465 ! BMP signaling pathway GO:0030509 18 18 0,000 0,14377221 0,17489913 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,14377221 0,17478376 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,14377221 0,17466854 ! positive regulation of protein kinase cascade GO:0010740 79 78 1,000 0,14390342 0,17471278 ! metal ion homeostasis GO:0055065 78 78 1,000 0,14390342 0,17459777 ! nuclear transport GO:0051169 79 79 1,000 0,14686428 0,17807294 GO:0006913|nucleocytoplasmic transport, ! DNA damage checkpoint GO:0000077 19 19 0,000 0,15113412 0,18312964 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,15113412 0,18300932 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,15113412 0,18288915 GO:0006956|complement activation, ! negative regulation of DNA metabolic process GO:0051053 19 19 0,000 0,15113412 0,18276915 ! regulation of pH GO:0006885 19 19 0,000 0,15113412 0,1826493 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,15113412 0,18252961 ! feeding behavior GO:0007631 19 19 0,000 0,15113412 0,18241007 ! peroxisome organization GO:0007031 19 19 0,000 0,15113412 0,18229069 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,15113412 0,18217147 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,15113412 0,1820524 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,15113412 0,18193349 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,15113412 0,18181474 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,15113412 0,18169614 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,15113412 0,18157769 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,15113412 0,1814594 ! eye morphogenesis GO:0048592 19 19 0,000 0,15113412 0,18134126 ! vesicle localization GO:0051648 20 19 0,000 0,15113412 0,18122328 ! lipid catabolic process GO:0016042 82 81 1,000 0,15282406 0,18313052 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,1584338 0,18972936 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,1584338 0,18960616 ! neural tube development GO:0021915 21 20 0,000 0,1584338 0,18948312 ! phagocytosis GO:0006909 21 20 0,000 0,1584338 0,18936024 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,1584338 0,18923751 ! protein targeting to membrane GO:0006612 22 20 0,000 0,1584338 0,18911495 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,1584338 0,18899255 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,1584338 0,1888703 ! lipid oxidation GO:0034440 20 20 0,000 0,1584338 0,18874821 GO:0019395|fatty acid oxidation, ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,1584338 0,18862628 ! RNA modification GO:0009451 20 20 0,000 0,1584338 0,18850451 ! regulation of B cell activation GO:0050864 20 20 0,000 0,1584338 0,18838289 ! mRNA catabolic process GO:0006402 21 21 0,000 0,16567176 0,19686205 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,16567176 0,19673521 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,16567176 0,19660853 ! Notch signaling pathway GO:0007219 22 21 0,000 0,16567176 0,19648201 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,16567176 0,19635566 ! ear morphogenesis GO:0042471 21 21 0,000 0,16567176 0,19622946 ! organic anion transport GO:0015711 21 21 0,000 0,16567176 0,19610343 ! cholesterol transport GO:0030301 21 21 0,000 0,16567176 0,19597756 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,16567176 0,19585186 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,16567176 0,19572631 GO:0032313|regulation of Rab GTPase activity, ! DNA integrity checkpoint GO:0031570 21 21 0,000 0,16567176 0,19560093 ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,16567176 0,1954757 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,16567176 0,19535064 ! regulation of proteolysis GO:0030162 21 21 0,000 0,16567176 0,19522573 ! negative regulation of hydrolase activity GO:0051346 21 21 0,000 0,16567176 0,19510099 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,16567176 0,1949764 ! organophosphate metabolic process GO:0019637 87 86 1,000 0,16792597 0,19750324 GO:0006644|phospholipid metabolic process, ! cellular amide metabolic process GO:0043603 22 22 0,000 0,17284851 0,20316314 ! regulation of ion transport GO:0043269 22 22 0,000 0,17284851 0,20303366 ! odontogenesis GO:0042476 22 22 0,000 0,17284851 0,20290433 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,17284851 0,20277518 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! hormone-mediated signaling GO:0009755 22 22 0,000 0,17284851 0,20264619 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,17284851 0,20251736 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,17284851 0,20238869 ! cell chemotaxis GO:0060326 23 22 0,000 0,17284851 0,20226019 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,17284851 0,20213186 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,17284851 0,20200368 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,17284851 0,20187567 ! biopolymer methylation GO:0043414 22 22 0,000 0,17284851 0,20174782 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,17284851 0,20162013 ! detection of external stimulus GO:0009581 23 22 0,000 0,17284851 0,2014926 ! neuron migration GO:0001764 22 22 0,000 0,17284851 0,20136524 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,17284851 0,20123803 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,17284851 0,20111099 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,17284851 0,2009841 ! aerobic respiration GO:0009060 22 22 0,000 0,17284851 0,20085738 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,17996457 0,20899477 ! viral infectious cycle GO:0019058 23 23 0,000 0,17996457 0,20886316 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,17996457 0,20873172 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,17996457 0,20860044 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,17996457 0,20846933 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,17996457 0,20833838 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,17996457 0,2082076 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,17996457 0,20807698 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,17996457 0,20794652 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,17996457 0,20781623 ! fatty acid metabolic process GO:0006631 93 92 1,000 0,18637336 0,21508209 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 1,000 0,18637336 0,21494749 ! positive regulation of immune system process GO:0002684 92 92 1,000 0,18637336 0,21481307 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,18702044 0,21542417 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,18702044 0,21528961 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,18702044 0,21515522 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,18702044 0,215021 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,18702044 0,21488695 ! glucan metabolic process GO:0044042 25 24 0,000 0,18702044 0,21475307 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! tissue morphogenesis GO:0048729 94 93 1,000 0,18947712 0,21743857 ! epidermis development GO:0008544 94 94 1,000 0,19258828 0,22087131 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,19401662 0,22237104 ! negative regulation of secretion GO:0051048 26 25 0,000 0,19401662 0,22223283 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,19401662 0,2220948 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,19401662 0,22195694 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,19401662 0,22181925 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,19401662 0,22168173 ! excretion GO:0007588 25 25 0,000 0,19401662 0,22154438 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,19401662 0,2214072 ! gastrulation GO:0007369 25 25 0,000 0,19401662 0,22127019 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,19401662 0,22113335 ! regulation of endocytosis GO:0030100 25 25 0,000 0,19401662 0,22099668 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,19401662 0,22086018 ! glycolysis GO:0006096 26 26 0,000 0,2009536 0,22861573 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,2009536 0,2284747 ! induction of apoptosis by intracellular signals GO:0008629 26 26 0,000 0,2009536 0,22833384 ! cellular defense response GO:0006968 26 26 0,000 0,2009536 0,22819315 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,2009536 0,22805264 ! double-strand break repair GO:0006302 27 26 0,000 0,2009536 0,2279123 ! regulation of protein secretion GO:0050708 26 26 0,000 0,2009536 0,22777213 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,2009536 0,22763214 GO:0035150|regulation of tube size, ! endocytosis GO:0006897 99 98 1,000 0,20509989 0,23218618 GO:0010324|membrane invagination, ! glycoprotein metabolic process GO:0009100 99 98 1,000 0,20509989 0,23204365 ! chloride transport GO:0006821 27 27 0,000 0,20783188 0,23499028 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,20783188 0,2348462 ! energy reserve metabolic process GO:0006112 28 27 0,000 0,20783188 0,2347023 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,20783188 0,23455858 ! peptide metabolic process GO:0006518 29 27 0,000 0,20783188 0,23441503 ! activation of caspase activity GO:0006919 27 27 0,000 0,20783188 0,23427166 ! inner ear development GO:0048839 27 27 0,000 0,20783188 0,23412846 ! defense response to bacterium GO:0042742 27 27 0,000 0,20783188 0,23398543 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,20783188 0,23384259 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,20783188 0,23369991 ! cell growth GO:0016049 27 27 0,000 0,20783188 0,23355741 ! ectoderm development GO:0007398 99 99 1,000 0,20824288 0,23387668 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,21465195 0,24092786 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! neuromuscular process GO:0050905 28 28 0,000 0,21465195 0,24078122 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,21465195 0,24063476 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,21465195 0,24048847 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,21465195 0,24034237 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,21465195 0,24019644 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,22141429 0,24761318 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,22141429 0,24746302 ! leukocyte migration GO:0050900 30 29 0,000 0,22141429 0,24731305 ! antigen processing and presentation GO:0019882 29 29 0,000 0,22141429 0,24716325 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,22141429 0,24701364 ! tRNA processing GO:0008033 29 29 0,000 0,22141429 0,2468642 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,22141429 0,24671495 ! adult behavior GO:0030534 30 29 0,000 0,22141429 0,24656588 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,22141429 0,24641699 ! transition metal ion transport GO:0000041 31 30 0,000 0,22811937 0,25372601 ! RNA catabolic process GO:0006401 30 30 0,000 0,22811937 0,25357298 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,22811937 0,25342014 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,22811937 0,25326747 GO:0043280|positive regulation of caspase activity, ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,22811937 0,25311499 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,22811937 0,2529627 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,22811937 0,25281059 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,22811937 0,25265866 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,22811937 0,25250691 GO:0019724|B cell mediated immunity, ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,22811937 0,25235535 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,22811937 0,25220396 ! establishment of organelle localization GO:0051656 31 30 0,000 0,22811937 0,25205276 ! regulation of translational initiation GO:0006446 31 31 0,000 0,23476769 0,25924317 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,23476769 0,25908793 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,23476769 0,25893288 ! ion transmembrane transport GO:0034220 31 31 0,000 0,23476769 0,25877802 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,23476769 0,25862334 ! digestion GO:0007586 31 31 0,000 0,23476769 0,25846885 ! regulation of heart contraction GO:0008016 31 31 0,000 0,23476769 0,25831454 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,23476769 0,25816041 ! camera-type eye development GO:0043010 31 31 0,000 0,23476769 0,25800647 ! extracellular matrix organization GO:0030198 31 31 0,000 0,23476769 0,25785271 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,23476769 0,25769914 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,23476769 0,25754574 ! cell redox homeostasis GO:0045454 32 32 0,000 0,2413597 0,26461983 ! glucose catabolic process GO:0006007 32 32 0,000 0,2413597 0,2644625 ! lipid modification GO:0030258 32 32 0,000 0,2413597 0,26430537 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,2413597 0,26414842 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,2413597 0,26399165 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,2413597 0,26383507 ! amino acid transport GO:0006865 33 33 0,000 0,24789588 0,27081927 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,24789588 0,27065884 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,24789588 0,27049859 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,24789588 0,27033853 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,24789588 0,27017866 ! regulation of actin filament length GO:0030832 34 34 0,000 0,2543767 0,27707817 ! cellular polysaccharide metabolic process GO:0044264 35 34 0,000 0,2543767 0,27691451 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,2543767 0,27675104 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,2543767 0,27658776 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,2543767 0,27642468 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,2543767 0,27626179 ! detection of stimulus GO:0051606 36 34 0,000 0,2543767 0,27609909 ! acute inflammatory response GO:0002526 35 35 0,000 0,26080261 0,28290713 ! regulation of cellular component size GO:0032535 35 35 0,000 0,26080261 0,28274071 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,26080261 0,28257449 ! mesoderm development GO:0007498 35 35 0,000 0,26080261 0,28240847 ! inorganic anion transport GO:0015698 35 35 0,000 0,26080261 0,28224264 ! regulation of immune effector process GO:0002697 35 35 0,000 0,26080261 0,282077 ! hydrogen transport GO:0006818 36 36 0,000 0,26717407 0,28879872 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,26717407 0,28862943 ! positive regulation of organelle organization GO:0010638 36 36 0,000 0,26717407 0,28846035 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,26717407 0,28829146 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,26717407 0,28812277 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,26717407 0,28795428 ! activation of immune response GO:0002253 36 36 0,000 0,26717407 0,28778598 ! coagulation GO:0050817 39 36 0,000 0,26717407 0,28761788 GO:0007596|blood coagulation, ! meiosis GO:0007126 37 37 0,000 0,27349153 0,29424688 GO:0051327|M phase of meiotic cell cycle, ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,27349153 0,2940752 ! eye development GO:0001654 37 37 0,000 0,27349153 0,29390373 ! DNA damage response, signal transduction GO:0042770 37 37 0,000 0,27349153 0,29373246 ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,27349153 0,29356139 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,27349153 0,29339051 ! positive regulation of secretion GO:0051047 39 38 0,000 0,27975545 0,2999356 ! neurotransmitter transport GO:0006836 40 38 0,000 0,27975545 0,29976122 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,27975545 0,29958704 ! exocytosis GO:0006887 40 38 0,000 0,27975545 0,29941307 ! hexose catabolic process GO:0019320 38 38 0,000 0,27975545 0,29923929 ! meiotic cell cycle GO:0051321 38 38 0,000 0,27975545 0,29906572 ! regulation of neurological system process GO:0031644 38 38 0,000 0,27975545 0,29889235 ! hemostasis GO:0007599 42 39 0,000 0,28596627 0,30535101 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,28596627 0,3051742 ! response to unfolded protein GO:0006986 39 39 0,000 0,28596627 0,30499759 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,28596627 0,30482119 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,28596627 0,304645 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,28596627 0,304469 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,28596627 0,30429321 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,28596627 0,30411762 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,29212444 0,31048751 ! organelle localization GO:0051640 41 40 0,000 0,29212444 0,31030855 ! amine catabolic process GO:0009310 42 41 0,000 0,29823038 0,31661209 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,29823038 0,31642982 ! regulation of caspase activity GO:0043281 41 41 0,000 0,29823038 0,31624775 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,29823038 0,31606589 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,29823038 0,31588425 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,29823038 0,31570281 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,29823038 0,31552158 ! regulation of endopeptidase activity GO:0052548 42 42 0,000 0,30428454 0,32174206 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,30428454 0,32155757 ! one-carbon metabolic process GO:0006730 42 42 0,000 0,30428454 0,3213733 ! alcohol catabolic process GO:0046164 43 43 0,000 0,31028735 0,32752554 ! mRNA transport GO:0051028 44 44 0,000 0,31623924 0,33361701 ! protein import into nucleus GO:0006606 44 44 0,000 0,31623924 0,33342615 ! vitamin metabolic process GO:0006766 44 44 0,000 0,31623924 0,33323551 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,31623924 0,33304509 ! amine biosynthetic process GO:0009309 46 45 0,000 0,32214062 0,33906635 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,32214062 0,33887281 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,32214062 0,3386795 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,32214062 0,33848641 ! nuclear import GO:0051170 45 45 0,000 0,32214062 0,33829355 ! protein processing GO:0016485 45 45 0,000 0,32214062 0,33810089 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,32799193 0,34404618 ! regulation of peptidase activity GO:0052547 46 46 0,000 0,32799193 0,34385048 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,33379358 0,3497337 ! regulation of blood pressure GO:0008217 48 47 0,000 0,33379358 0,34953499 ! amine transport GO:0015837 47 47 0,000 0,33379358 0,3493365 ! calcium ion transport GO:0006816 48 48 0,000 0,33954599 0,35515508 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,33954599 0,35495363 ! protein localization in nucleus GO:0034504 48 48 0,000 0,33954599 0,35475241 ! DNA recombination GO:0006310 48 48 0,000 0,33954599 0,35455142 ! divalent metal ion transport GO:0070838 49 49 0,000 0,34524956 0,36030291 ! response to bacterium GO:0009617 50 49 0,000 0,34524956 0,360099 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,34524956 0,35989533 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,34524956 0,35969188 GO:0002696|positive regulation of leukocyte activation, ! chromatin assembly GO:0031497 50 50 0,000 0,3509047 0,36537704 GO:0006334|nucleosome assembly, ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,3509047 0,36517073 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,35651182 0,37079644 ! positive regulation of immune response GO:0050778 51 51 0,000 0,35651182 0,3705873 ! rRNA metabolic process GO:0016072 51 51 0,000 0,35651182 0,3703784 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,35651182 0,37016974 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,35651182 0,36996131 ! protein maturation GO:0051604 51 51 0,000 0,35651182 0,36975311 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,36207132 0,37530789 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,36207132 0,37509693 ! regulation of body fluid levels GO:0050878 55 52 0,000 0,36207132 0,3748862 ! sodium ion transport GO:0006814 53 53 0,000 0,36758359 0,38037987 ! tRNA metabolic process GO:0006399 53 53 0,000 0,36758359 0,38016642 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,36758359 0,3799532 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,36758359 0,37974022 ! hormone metabolic process GO:0042445 55 54 0,000 0,37304903 0,38517051 ! sulfur metabolic process GO:0006790 55 54 0,000 0,37304903 0,38495485 ! nucleosome organization GO:0034728 55 55 0,000 0,37846803 0,39032825 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,37846803 0,39010995 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,38384098 0,39542701 ! ATP metabolic process GO:0046034 57 57 0,000 0,38916827 0,40069112 ! innate immune response GO:0045087 58 58 0,000 0,39445026 0,40590276 ! carboxylic acid transport GO:0046942 59 59 0,000 0,39968735 0,41106238 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 0,000 0,39968735 0,41083313 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,39968735 0,41060412 ! protein localization in organelle GO:0033365 59 59 0,000 0,39968735 0,41037537 ! potassium ion transport GO:0006813 60 60 0,000 0,40487991 0,41547532 ! protein polymerization GO:0051258 65 60 0,000 0,40487991 0,41524412 ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,41002831 0,42029042 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,41002831 0,4200568 ! lipid transport GO:0006869 62 62 0,000 0,41513292 0,42504999 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,41513292 0,42481398 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,41513292 0,42457823 ! protein import GO:0017038 62 62 0,000 0,41513292 0,42434275 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,41513292 0,42410753 ! regulation of secretion GO:0051046 65 63 0,000 0,42019411 0,4290403 ! glucose metabolic process GO:0006006 63 63 0,000 0,42019411 0,42880273 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,42019411 0,42856543 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,42019411 0,4283284 ! regulation of cytoskeleton organization GO:0051493 66 64 0,000 0,42521223 0,43320406 ! anion transport GO:0006820 65 65 0,000 0,43018765 0,43803085 ! positive regulation of cellular component organization GO:0051130 65 65 0,000 0,43018765 0,43778898 ! regulation of hormone levels GO:0010817 66 65 0,000 0,43018765 0,43754738 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,43512073 0,44232074 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! DNA packaging GO:0006323 66 66 0,000 0,43512073 0,44207691 ! polysaccharide metabolic process GO:0005976 69 66 0,000 0,43512073 0,44183334 ! muscle contraction GO:0006936 67 67 0,000 0,44001182 0,44655385 ! negative regulation of cell differentiation GO:0045596 68 67 0,000 0,44001182 0,44630808 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,44486127 0,45097872 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,44486127 0,4507308 ! sensory perception of sound GO:0007605 71 69 0,000 0,44966943 0,45535206 GO:0050954|sensory perception of mechanical stimulus, ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,45443664 0,45992682 GO:0016053|organic acid biosynthetic process, ! translational elongation GO:0006414 71 71 0,000 0,45916326 0,46445548 ! ribosome biogenesis GO:0042254 71 71 0,000 0,45916326 0,4642007 ! secretion by cell GO:0032940 75 72 0,000 0,46384961 0,46868138 ! muscle system process GO:0003012 72 72 0,000 0,46384961 0,46842456 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,47310287 0,47750744 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,47767045 0,48185366 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,47767045 0,48159006 ! microtubule-based movement GO:0007018 82 78 0,000 0,4911409 0,49490032 ! regulation of immune response GO:0050776 78 78 0,000 0,4911409 0,49462988 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,49993087 0,50320731 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,51283664 0,5159159 ! ncRNA processing GO:0034470 83 83 0,000 0,51283664 0,51563444 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,51706537 0,51960277 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,521258 0,52353052 ! hexose metabolic process GO:0019318 87 86 0,000 0,52541485 0,52741806 ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,53362238 0,5353653 ! chemotaxis GO:0006935 90 89 0,000 0,53767366 0,53913632 GO:0042330|taxis, ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,54169034 0,54286856 ! DNA replication GO:0006260 91 91 0,000 0,5456727 0,54656239 ! visual perception GO:0007601 93 92 0,000 0,54962105 0,55021814 GO:0050953|sensory perception of light stimulus, ! cofactor metabolic process GO:0051186 95 94 0,000 0,55741681 0,55771942 ! regulation of system process GO:0044057 98 98 0,000 0,57261248 0,57261248