pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6935-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of phosphorylation GO:0042326 41 23 5,000 2,427E-08 5,582E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 6,000 3,145E-08 3,617E-05 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 4,201E-08 3,221E-05 GO:0045936|negative regulation of phosphate metabolic process, ! induction of positive chemotaxis GO:0050930 14 8 3,000 2,929E-07 1,684E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 3,000 2,929E-07 1,347E-04 ! positive regulation of locomotion GO:0040017 35 20 4,000 4,795E-07 1,838E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 4,000 6,252E-07 2,054E-04 ! regulation of behavior GO:0050795 38 22 4,000 8,037E-07 2,311E-04 ! filopodium assembly GO:0046847 19 11 3,000 1,355E-06 3,462E-04 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 1,355E-06 3,116E-04 GO:0050927|positive regulation of positive chemotaxis, ! response to UV GO:0009411 75 46 5,000 1,929E-06 4,034E-04 ! microspike assembly GO:0030035 23 12 3,000 2,019E-06 3,87E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 2,898E-06 5,128E-04 ! nuclear migration GO:0007097 10 5 2,000 5,296E-06 8,7E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 5,296E-06 8,12E-04 GO:0031272|regulation of pseudopodium assembly, ! cell cycle arrest GO:0007050 150 86 6,000 6,627E-06 9,527E-04 ! developmental maturation GO:0021700 75 57 5,000 6,942E-06 9,392E-04 ! establishment or maintenance of cell polarity GO:0007163 61 34 4,000 7,848E-06 1,003E-03 ! regulation of intracellular protein transport GO:0033157 59 35 4,000 9,096E-06 1,101E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 3,000 9,405E-06 1,082E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 2,000 1,053E-05 1,153E-03 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 1,053E-05 1,101E-03 ! ER overload response GO:0006983 7 6 2,000 1,053E-05 1,053E-03 ! macrophage differentiation GO:0030225 10 6 2,000 1,053E-05 1,009E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 1,512E-05 1,391E-03 ! positive regulation of intracellular transport GO:0032388 29 19 3,000 1,512E-05 1,338E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 4,000 1,571E-05 1,339E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 1,784E-05 1,465E-03 ! positive regulation of protein transport GO:0051222 55 40 4,000 1,784E-05 1,415E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,831E-05 1,404E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,831E-05 1,359E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 1,831E-05 1,316E-03 ! positive regulation of inflammatory response GO:0050729 30 20 3,000 1,878E-05 1,309E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 2,276E-05 1,54E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 2,559E-05 1,682E-03 ! vasculogenesis GO:0001570 33 22 3,000 2,8E-05 1,789E-03 ! regulation of inflammatory response GO:0050727 60 44 4,000 2,868E-05 1,783E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,912E-05 1,763E-03 ! negative regulation of transport GO:0051051 116 73 5,000 2,925E-05 1,725E-03 ! cell maturation GO:0048469 60 45 4,000 3,206E-05 1,843E-03 ! response to molecule of bacterial origin GO:0002237 30 23 3,000 3,368E-05 1,889E-03 ! regulation of protein transport GO:0051223 114 76 5,000 3,682E-05 2,016E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 4,342E-05 2,323E-03 ! DNA ligation GO:0006266 14 9 2,000 4,342E-05 2,27E-03 ! nucleus localization GO:0051647 15 9 2,000 4,342E-05 2,219E-03 ! regulation of angiogenesis GO:0045765 94 49 4,000 4,874E-05 2,437E-03 ! regulation of intracellular transport GO:0032386 78 49 4,000 4,874E-05 2,385E-03 ! negative regulation of protein modification process GO:0031400 50 26 3,000 5,579E-05 2,673E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 6,166E-05 2,894E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 2,000 6,166E-05 2,837E-03 ! response to X-ray GO:0010165 16 10 2,000 6,166E-05 2,781E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 6,166E-05 2,727E-03 ! protein sumoylation GO:0016925 12 10 2,000 6,166E-05 2,676E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 2,000 6,166E-05 2,626E-03 ! regulation of protein localization GO:0032880 132 85 5,000 6,936E-05 2,9E-03 ! cell projection assembly GO:0030031 76 53 4,000 7,144E-05 2,934E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 8,428E-05 3,401E-03 ! regulation of leukocyte migration GO:0002685 24 11 2,000 8,428E-05 3,342E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 8,428E-05 3,285E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 1,015E-04 3,893E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 1,104E-04 4,163E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,117E-04 4,144E-03 ! leukocyte chemotaxis GO:0030595 43 31 3,000 1,138E-04 4,153E-03 GO:0060326|cell chemotaxis, ! regulation of response to external stimulus GO:0032101 139 96 5,000 1,366E-04 4,909E-03 ! response to light stimulus GO:0009416 153 96 5,000 1,366E-04 4,833E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 1,405E-04 4,898E-03 ! positive regulation of protein import into nucleus GO:0042307 23 13 2,000 1,443E-04 4,955E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 5,000 1,618E-04 5,473E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 1,639E-04 5,463E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,826E-04 6E-03 ! neuron maturation GO:0042551 21 14 2,000 1,826E-04 5,915E-03 ! regulation of caspase activity GO:0043281 97 65 4,000 1,901E-04 6,072E-03 ! regulation of endopeptidase activity GO:0052548 99 67 4,000 2,194E-04 6,912E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 2,269E-04 7,052E-03 ! activation of protein kinase activity GO:0032147 102 69 4,000 2,52E-04 7,727E-03 ! pigmentation GO:0043473 74 38 3,000 2,553E-04 7,725E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 2,696E-04 8,052E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,776E-04 8,185E-03 ! regulation of peptidase activity GO:0052547 106 72 4,000 3,076E-04 8,955E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 3,076E-04 8,843E-03 GO:0045937|positive regulation of phosphate metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 2,000 3,35E-04 9,514E-03 ! negative regulation of protein catabolic process GO:0042177 26 17 2,000 3,35E-04 9,398E-03 ! response to nutrient GO:0007584 104 75 4,000 3,721E-04 0,01031043 ! regulation of cell shape GO:0008360 78 42 3,000 3,774E-04 0,01033371 ! pancreas development GO:0031016 26 18 2,000 3,997E-04 0,01081413 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 3,997E-04 0,01068838 ! response to retinoic acid GO:0032526 25 18 2,000 3,997E-04 0,01056553 ! regulation of glucose import GO:0046324 21 18 2,000 3,997E-04 0,01044546 GO:0010827|regulation of glucose transport, ! leukocyte migration GO:0050900 60 43 3,000 4,135E-04 0,01068566 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 4,52E-04 0,01155033 ! response to vitamin A GO:0033189 26 19 2,000 4,718E-04 0,0119234 ! apoptotic nuclear changes GO:0030262 24 19 2,000 4,718E-04 0,0117938 ! sex determination GO:0007530 29 19 2,000 4,718E-04 0,01166698 ! positive regulation of cell cycle GO:0045787 77 45 3,000 4,929E-04 0,01206122 ! positive regulation of defense response GO:0031349 59 45 3,000 4,929E-04 0,01193426 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 4,929E-04 0,01180994 ! response to vitamin GO:0033273 29 20 2,000 5,517E-04 0,01308125 ! DNA modification GO:0006304 28 20 2,000 5,517E-04 0,01294777 ! positive regulation of B cell activation GO:0050871 31 20 2,000 5,517E-04 0,01281698 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 5,827E-04 0,01340188 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of defense response GO:0031347 117 84 4,000 6,276E-04 0,01429088 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 6,398E-04 0,0144267 ! cell aging GO:0007569 32 21 2,000 6,398E-04 0,01428664 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 6,398E-04 0,01414926 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 6,398E-04 0,01401451 ! sleep GO:0030431 11 5 1,000 6,538E-04 0,01418627 ! negative regulation of bone resorption GO:0045779 10 5 1,000 6,538E-04 0,01405369 ! regulation of collagen biosynthetic process GO:0032965 6 5 1,000 6,538E-04 0,01392356 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 6,538E-04 0,01379582 ! rhythmic behavior GO:0007622 12 5 1,000 6,538E-04 0,0136704 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 1,000 6,538E-04 0,01354725 ! response to protozoan GO:0001562 9 5 1,000 6,538E-04 0,01342629 ! anagen GO:0042640 6 5 1,000 6,538E-04 0,01330747 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 6,538E-04 0,01319074 ! epithelial cell proliferation GO:0050673 6 5 1,000 6,538E-04 0,01307604 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 6,538E-04 0,01296331 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 6,538E-04 0,01285252 ! neutrophil mediated immunity GO:0002446 6 5 1,000 6,538E-04 0,0127436 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 1,000 6,538E-04 0,01263651 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 1,000 6,538E-04 0,0125312 GO:0030033|microvillus assembly, ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 1,000 6,538E-04 0,01242764 GO:0043088|regulation of Cdc42 GTPase activity, ! early endosome to late endosome transport GO:0045022 11 5 1,000 6,538E-04 0,01232577 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 6,538E-04 0,01222556 ! depyrimidination GO:0045008 8 5 1,000 6,538E-04 0,01212697 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 6,538E-04 0,01202996 GO:0045686|negative regulation of glial cell differentiation, ! centrosome duplication GO:0051298 5 5 1,000 6,538E-04 0,01193448 ! response to UV-C GO:0010225 6 5 1,000 6,538E-04 0,01184051 ! positive regulation of chemokine production GO:0032722 7 5 1,000 6,538E-04 0,011748 ! enteric nervous system development GO:0048484 8 5 1,000 6,538E-04 0,01165693 ! apical protein localization GO:0045176 6 5 1,000 6,538E-04 0,01156726 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 6,538E-04 0,01147897 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 6,988E-04 0,01217542 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 7,364E-04 0,01273459 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 7,364E-04 0,01263956 ! blastocyst development GO:0001824 37 22 2,000 7,364E-04 0,01254593 ! interphase GO:0051325 159 88 4,000 7,758E-04 0,01312098 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 7,96E-04 0,01336371 ! positive regulation of cell migration GO:0030335 92 51 3,000 7,96E-04 0,01326688 ! regulation of protein catabolic process GO:0042176 77 51 3,000 7,96E-04 0,01317143 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 8,418E-04 0,01382954 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 8,418E-04 0,01373146 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 8,418E-04 0,01363476 ! negative regulation of DNA replication GO:0008156 35 23 2,000 8,418E-04 0,01353941 ! negative regulation of catabolic process GO:0009895 34 23 2,000 8,418E-04 0,01344539 ! establishment of organelle localization GO:0051656 85 52 3,000 8,569E-04 0,01359252 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 9,563E-04 0,01506528 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 9,563E-04 0,01496279 ! negative regulation of cell development GO:0010721 56 24 2,000 9,563E-04 0,01486169 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 2,000 9,563E-04 0,01476195 ! regulation of helicase activity GO:0051095 11 6 1,000 9,754E-04 0,01495673 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 9,754E-04 0,01485768 ! male meiosis GO:0007140 7 6 1,000 9,754E-04 0,01475993 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 9,754E-04 0,01466346 ! mRNA stabilization GO:0048255 15 6 1,000 9,754E-04 0,01456825 GO:0043489|RNA stabilization, ! erythrocyte maturation GO:0043249 6 6 1,000 9,754E-04 0,01447426 ! activation of MAPKKK activity GO:0000185 10 6 1,000 9,754E-04 0,01438147 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 9,754E-04 0,01428987 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 9,754E-04 0,01419943 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 9,754E-04 0,01411013 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 9,754E-04 0,01402194 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 9,754E-04 0,01393484 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of collagen metabolic process GO:0010712 7 6 1,000 9,754E-04 0,01384883 ! DNA topological change GO:0006265 8 6 1,000 9,754E-04 0,01376386 ! hair follicle maturation GO:0048820 7 6 1,000 9,754E-04 0,01367994 ! neutrophil homeostasis GO:0001780 6 6 1,000 9,754E-04 0,01359703 ! salivary gland morphogenesis GO:0007435 11 6 1,000 9,754E-04 0,01351512 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 9,754E-04 0,01343419 ! blastocyst growth GO:0001832 15 6 1,000 9,754E-04 0,01335423 ! organ or tissue specific immune response GO:0002251 7 6 1,000 9,754E-04 0,01327521 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 9,754E-04 0,01319712 ! cytokine-mediated signaling pathway GO:0019221 76 54 3,000 9,885E-04 0,01329515 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,08E-03 0,01444515 ! positive regulation of cell motion GO:0051272 99 56 3,000 1,134E-03 0,01507097 ! gonad development GO:0008406 79 57 3,000 1,211E-03 0,01601395 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 2,000 1,214E-03 0,01595373 ! regulation of pH GO:0006885 36 26 2,000 1,214E-03 0,01586309 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,214E-03 0,01577347 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 2,000 1,214E-03 0,01568485 ! response to ionizing radiation GO:0010212 47 27 2,000 1,357E-03 0,01744235 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,357E-03 0,01734545 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,358E-03 0,01726003 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,358E-03 0,0171652 ! negative regulation of muscle cell differentiation GO:0051148 9 7 1,000 1,358E-03 0,0170714 ! microtubule bundle formation GO:0001578 8 7 1,000 1,358E-03 0,01697862 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,358E-03 0,01688684 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 1,000 1,358E-03 0,01679606 ! asymmetric protein localization GO:0008105 8 7 1,000 1,358E-03 0,01670624 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,358E-03 0,01661737 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,358E-03 0,01652945 ! B cell lineage commitment GO:0002326 17 7 1,000 1,358E-03 0,01644245 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,358E-03 0,01635637 ! T cell lineage commitment GO:0002360 12 7 1,000 1,358E-03 0,01627118 ! response to tumor cell GO:0002347 12 7 1,000 1,358E-03 0,01618687 ! neuroblast proliferation GO:0007405 13 7 1,000 1,358E-03 0,01610343 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 1,358E-03 0,01602085 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 1,358E-03 0,01593911 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 1,000 1,358E-03 0,0158582 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,358E-03 0,01577811 ! defense response to Gram-negative bacterium GO:0050829 9 7 1,000 1,358E-03 0,01569883 ! actin filament organization GO:0007015 95 59 3,000 1,378E-03 0,01585134 ! myeloid cell differentiation GO:0030099 85 59 3,000 1,378E-03 0,01577248 ! regulation of homeostatic process GO:0032844 105 60 3,000 1,468E-03 0,0167098 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 1,511E-03 0,01712325 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,511E-03 0,01703932 ! regulation of B cell activation GO:0050864 42 28 2,000 1,511E-03 0,0169562 ! urogenital system development GO:0001655 101 61 3,000 1,561E-03 0,01742507 ! negative regulation of cell growth GO:0030308 106 62 3,000 1,658E-03 0,01842043 ! organelle localization GO:0051640 96 62 3,000 1,658E-03 0,01833187 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,676E-03 0,0184403 ! regulation of transcription factor activity GO:0051090 97 63 3,000 1,759E-03 0,01926658 GO:0090046|regulation of transcription regulator activity, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,801E-03 0,01963551 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,801E-03 0,01954289 ! prostaglandin biosynthetic process GO:0001516 13 8 1,000 1,801E-03 0,01945114 GO:0046457|prostanoid biosynthetic process, ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,801E-03 0,01936025 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,801E-03 0,0192702 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,801E-03 0,01918099 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,801E-03 0,01909259 ! multicellular organism growth GO:0035264 14 8 1,000 1,801E-03 0,01900501 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,801E-03 0,01891823 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 1,000 1,801E-03 0,01883224 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,801E-03 0,01874703 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,801E-03 0,01866258 ! myeloid cell homeostasis GO:0002262 8 8 1,000 1,801E-03 0,01857889 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,801E-03 0,01849595 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 1,000 1,801E-03 0,01841375 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,801E-03 0,01833227 ! negative regulation of cell size GO:0045792 108 64 3,000 1,865E-03 0,01889265 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 1,865E-03 0,01880979 ! reproductive structure development GO:0048608 90 65 3,000 1,974E-03 0,0198305 ! protein oligomerization GO:0051259 100 65 3,000 1,974E-03 0,01974428 ! mammary gland development GO:0030879 57 31 2,000 2,037E-03 0,02028059 ! metanephros development GO:0001656 58 31 2,000 2,037E-03 0,02019317 ! response to mechanical stimulus GO:0009612 43 31 2,000 2,037E-03 0,02010651 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 2,234E-03 0,02196033 ! monovalent inorganic cation homeostasis GO:0055067 45 32 2,000 2,234E-03 0,02186688 ! calcium-mediated signaling GO:0019722 50 32 2,000 2,234E-03 0,02177422 ! lung alveolus development GO:0048286 17 9 1,000 2,304E-03 0,02235569 ! ventral spinal cord development GO:0021517 11 9 1,000 2,304E-03 0,02226175 ! myeloid leukocyte mediated immunity GO:0002444 11 9 1,000 2,304E-03 0,02216861 ! L-serine metabolic process GO:0006563 13 9 1,000 2,304E-03 0,02207624 ! receptor clustering GO:0043113 15 9 1,000 2,304E-03 0,02198464 ! motor axon guidance GO:0008045 14 9 1,000 2,304E-03 0,02189379 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 2,304E-03 0,02180369 ! base-excision repair, AP site formation GO:0006285 12 9 1,000 2,304E-03 0,02171433 ! erythrocyte development GO:0048821 11 9 1,000 2,304E-03 0,0216257 ! postreplication repair GO:0006301 11 9 1,000 2,304E-03 0,02153779 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,304E-03 0,0214506 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,304E-03 0,0213641 ! oocyte differentiation GO:0009994 12 9 1,000 2,304E-03 0,0212783 GO:0048599|oocyte development, ! blastocyst formation GO:0001825 12 9 1,000 2,304E-03 0,02119319 ! defense response to Gram-positive bacterium GO:0050830 10 9 1,000 2,304E-03 0,02110876 ! embryonic placenta development GO:0001892 12 9 1,000 2,304E-03 0,02102499 ! localization within membrane GO:0051668 15 9 1,000 2,304E-03 0,02094189 ! development of primary sexual characteristics GO:0045137 92 68 3,000 2,331E-03 0,02110354 ! cell junction organization GO:0034330 63 33 2,000 2,443E-03 0,02203527 ! nucleus organization GO:0006997 49 33 2,000 2,443E-03 0,02194919 ! cytokinesis GO:0000910 52 33 2,000 2,443E-03 0,02186378 ! response to drug GO:0042493 108 69 3,000 2,458E-03 0,02191667 ! regulation of catabolic process GO:0009894 106 70 3,000 2,591E-03 0,02301012 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 2,664E-03 0,02356212 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 2,664E-03 0,02347185 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 1,000 2,864E-03 0,02514281 ! neuron fate specification GO:0048665 11 10 1,000 2,864E-03 0,02504721 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,864E-03 0,02495233 ! hippocampus development GO:0021766 19 10 1,000 2,864E-03 0,02485817 ! blood vessel remodeling GO:0001974 21 10 1,000 2,864E-03 0,02476472 ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 2,864E-03 0,02467197 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,864E-03 0,02457991 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,864E-03 0,02448853 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,864E-03 0,02439783 ! regulation of bone resorption GO:0045124 24 10 1,000 2,864E-03 0,02430781 ! positive regulation of interleukin-6 production GO:0032755 13 10 1,000 2,864E-03 0,02421844 ! DNA methylation GO:0006306 15 10 1,000 2,864E-03 0,02412973 GO:0006305|DNA alkylation, ! salivary gland development GO:0007431 22 10 1,000 2,864E-03 0,02404166 ! positive regulation of acute inflammatory response GO:0002675 14 10 1,000 2,864E-03 0,02395424 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 2,864E-03 0,02386745 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,864E-03 0,02378128 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 2,896E-03 0,0239593 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to steroid hormone stimulus GO:0048545 114 73 3,000 3,018E-03 0,02488342 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 3,14E-03 0,02579666 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 2,000 3,14E-03 0,02570486 ! negative regulation of growth GO:0045926 123 75 3,000 3,329E-03 0,02714866 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 3,482E-03 0,02829756 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,482E-03 0,02819792 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 3,482E-03 0,02809898 GO:0000725|recombinational repair, ! detection of mechanical stimulus GO:0050982 15 11 1,000 3,482E-03 0,02800073 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 3,482E-03 0,02790317 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 3,482E-03 0,02780628 ! negative regulation of proteolysis GO:0045861 16 11 1,000 3,482E-03 0,02771007 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,482E-03 0,02761452 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 1,000 3,482E-03 0,02751962 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 3,482E-03 0,02742537 ! focal adhesion formation GO:0048041 24 11 1,000 3,482E-03 0,02733177 ! regulation of intracellular pH GO:0051453 17 11 1,000 3,482E-03 0,02723881 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 3,482E-03 0,02714647 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 3,482E-03 0,02705476 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 3,482E-03 0,02696367 ! nitric oxide metabolic process GO:0046209 14 11 1,000 3,482E-03 0,02687319 GO:0006809|nitric oxide biosynthetic process, ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 1,000 3,482E-03 0,02678331 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 3,482E-03 0,02669403 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 3,482E-03 0,02660535 GO:0042130|negative regulation of T cell proliferation, ! regulation of cell morphogenesis GO:0022604 140 76 3,000 3,492E-03 0,02659169 ! regulation of DNA binding GO:0051101 119 77 3,000 3,66E-03 0,02778134 ! gland development GO:0048732 148 77 3,000 3,66E-03 0,02768995 ! sex differentiation GO:0007548 105 77 3,000 3,66E-03 0,02759917 ! regulation of T cell proliferation GO:0042129 58 38 2,000 3,667E-03 0,02755939 ! mesenchymal cell development GO:0014031 64 38 2,000 3,667E-03 0,02746962 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of protein modification process GO:0031401 107 78 3,000 3,834E-03 0,02862752 ! male sex differentiation GO:0046661 53 39 2,000 3,949E-03 0,02939081 ! developmental growth GO:0048589 62 39 2,000 3,949E-03 0,02929601 ! histone acetylation GO:0016573 23 12 1,000 4,156E-03 0,03073463 ! autonomic nervous system development GO:0048483 23 12 1,000 4,156E-03 0,03063612 ! gland morphogenesis GO:0022612 23 12 1,000 4,156E-03 0,03053824 ! peptidyl-lysine modification GO:0018205 18 12 1,000 4,156E-03 0,03044099 ! regulation of mRNA stability GO:0043488 27 12 1,000 4,156E-03 0,03034435 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 4,156E-03 0,03024832 ! response to cold GO:0009409 14 12 1,000 4,156E-03 0,0301529 ! double-strand break repair GO:0006302 67 40 2,000 4,243E-03 0,03069158 ! epithelial cell differentiation GO:0030855 55 41 2,000 4,551E-03 0,0328152 ! positive regulation of DNA binding GO:0043388 57 41 2,000 4,551E-03 0,03271265 ! regulation of T cell differentiation GO:0045580 59 41 2,000 4,551E-03 0,03261074 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 4,885E-03 0,03489445 ! regulation of chemokine production GO:0032642 17 13 1,000 4,885E-03 0,03478642 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 4,885E-03 0,03467905 ! endocrine pancreas development GO:0031018 19 13 1,000 4,885E-03 0,03457235 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 4,885E-03 0,0344663 ! deoxyribonucleotide catabolic process GO:0009264 16 13 1,000 4,885E-03 0,0343609 ! exocrine system development GO:0035272 27 13 1,000 4,885E-03 0,03425614 ! bone mineralization GO:0030282 15 13 1,000 4,885E-03 0,03415202 ! regulation of cellular pH GO:0030641 20 13 1,000 4,885E-03 0,03404852 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,885E-03 0,03394566 ! cellular pigmentation GO:0033059 24 13 1,000 4,885E-03 0,03384341 ! regulation of acute inflammatory response GO:0002673 19 13 1,000 4,885E-03 0,03374178 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 1,000 4,885E-03 0,03364076 ! regulation of RNA stability GO:0043487 28 13 1,000 4,885E-03 0,03354034 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 4,994E-03 0,03418696 ! activation of caspase activity GO:0006919 65 43 2,000 5,207E-03 0,03553612 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 5,207E-03 0,03543098 ! response to insulin stimulus GO:0032868 63 43 2,000 5,207E-03 0,03532647 ! positive regulation of binding GO:0051099 59 43 2,000 5,207E-03 0,03522256 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 5,208E-03 0,03512853 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 5,208E-03 0,03502582 ! regulation of cell projection organization GO:0031344 83 44 2,000 5,555E-03 0,03724746 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 5,555E-03 0,03713918 ! skeletal muscle tissue development GO:0007519 123 87 3,000 5,654E-03 0,03769507 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 5,654E-03 0,03758612 ! regulation of S phase GO:0033261 18 14 1,000 5,669E-03 0,03757546 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,669E-03 0,03746748 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 5,669E-03 0,03736012 ! limbic system development GO:0021761 25 14 1,000 5,669E-03 0,03725338 ! activation of MAPKK activity GO:0000186 21 14 1,000 5,669E-03 0,03714725 ! cellular response to starvation GO:0009267 21 14 1,000 5,669E-03 0,03704171 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 5,669E-03 0,03693678 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 5,669E-03 0,03683244 ! G1/S transition checkpoint GO:0031575 33 14 1,000 5,669E-03 0,03672868 ! DNA unwinding during replication GO:0006268 21 14 1,000 5,669E-03 0,03662551 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 1,000 5,669E-03 0,03652292 ! regulation of T-helper 2 type immune response GO:0002828 21 14 1,000 5,669E-03 0,0364209 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 5,669E-03 0,03631945 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 5,669E-03 0,03621856 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 1,000 5,669E-03 0,03611824 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,669E-03 0,03601846 ! peptide hormone secretion GO:0030072 23 14 1,000 5,669E-03 0,03591924 ! reproductive developmental process GO:0003006 127 89 3,000 6,125E-03 0,03870285 ! leukocyte differentiation GO:0002521 143 90 3,000 6,37E-03 0,04014023 ! protein modification by small protein conjugation GO:0032446 140 90 3,000 6,37E-03 0,04003055 ! negative regulation of hormone secretion GO:0046888 20 15 1,000 6,506E-03 0,0407748 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 6,506E-03 0,04066399 ! lipid phosphorylation GO:0046834 23 15 1,000 6,506E-03 0,04055379 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 6,506E-03 0,04044419 ! regulation of neurotransmitter secretion GO:0046928 26 15 1,000 6,506E-03 0,04033517 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 6,506E-03 0,04022675 ! myoblast differentiation GO:0045445 27 15 1,000 6,506E-03 0,0401189 ! centrosome cycle GO:0007098 16 15 1,000 6,506E-03 0,04001163 ! regulation of survival gene product expression GO:0045884 20 15 1,000 6,506E-03 0,03990493 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 6,506E-03 0,0397988 ! peptide secretion GO:0002790 27 15 1,000 6,506E-03 0,03969324 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 6,506E-03 0,03958823 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 6,506E-03 0,03948377 ! biomineral formation GO:0031214 18 15 1,000 6,506E-03 0,03937987 ! regulation of T-helper cell differentiation GO:0045622 23 15 1,000 6,506E-03 0,03927651 ! dopamine metabolic process GO:0042417 30 15 1,000 6,506E-03 0,03917369 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 6,506E-03 0,03907141 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 6,506E-03 0,03896966 ! defense response to virus GO:0051607 27 15 1,000 6,506E-03 0,03886844 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 6,506E-03 0,03876775 ! response to estrogen stimulus GO:0043627 74 47 2,000 6,681E-03 0,03970541 ! cell fate commitment GO:0045165 141 92 3,000 6,879E-03 0,04077921 ! positive regulation of caspase activity GO:0043280 72 48 2,000 7,084E-03 0,0418857 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 7,084E-03 0,0417783 ! regulation of DNA replication GO:0006275 75 48 2,000 7,084E-03 0,04167145 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 7,084E-03 0,04156515 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 7,144E-03 0,0418078 ! hormone secretion GO:0046879 25 16 1,000 7,396E-03 0,0431749 ! protein amino acid acetylation GO:0006473 28 16 1,000 7,396E-03 0,04306559 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 1,000 7,396E-03 0,04295684 ! oogenesis GO:0048477 23 16 1,000 7,396E-03 0,04284864 ! neural crest cell migration GO:0001755 24 16 1,000 7,396E-03 0,04274098 ! response to oxidative stress GO:0006979 141 94 3,000 7,415E-03 0,04274147 ! germ cell development GO:0007281 68 49 2,000 7,502E-03 0,0431341 ! cartilage development GO:0051216 70 49 2,000 7,502E-03 0,04302653 ! regulation of binding GO:0051098 151 95 3,000 7,692E-03 0,04401151 ! skeletal muscle fiber development GO:0048741 73 50 2,000 7,933E-03 0,04527682 ! membrane fusion GO:0006944 80 50 2,000 7,933E-03 0,04516475 ! in utero embryonic development GO:0001701 147 96 3,000 7,977E-03 0,04530115 ! protein modification by small protein conjugation or removal GO:0070647 148 96 3,000 7,977E-03 0,04518957 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 8,268E-03 0,04672485 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 8,338E-03 0,04700069 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 1,000 8,338E-03 0,04688578 GO:0019692|deoxyribose phosphate metabolic process, ! signal complex assembly GO:0007172 29 17 1,000 8,338E-03 0,04677142 ! regulation of viral genome replication GO:0045069 24 17 1,000 8,338E-03 0,04665762 ! DNA duplex unwinding GO:0032508 25 17 1,000 8,338E-03 0,04654438 GO:0032392|DNA geometric change, ! cell-substrate junction assembly GO:0007044 39 17 1,000 8,338E-03 0,04643168 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 8,338E-03 0,04631952 ! actin filament bundle formation GO:0051017 26 17 1,000 8,338E-03 0,04620791 ! neuromuscular junction development GO:0007528 23 17 1,000 8,338E-03 0,04609683 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 8,338E-03 0,04598629 ! peptidyl-serine modification GO:0018209 27 17 1,000 8,338E-03 0,04587628 ! cell-cell junction organization GO:0045216 25 17 1,000 8,338E-03 0,04576679 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 8,338E-03 0,04565782 ! proximal/distal pattern formation GO:0009954 25 17 1,000 8,338E-03 0,04554937 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 8,338E-03 0,04544143 ! positive regulation of secretion GO:0051047 71 51 2,000 8,379E-03 0,04556156 ! muscle fiber development GO:0048747 74 51 2,000 8,379E-03 0,0454541 ! aging GO:0007568 79 52 2,000 8,84E-03 0,04783958 ! nucleotide-excision repair GO:0006289 64 52 2,000 8,84E-03 0,04772728 ! regulation of bone remodeling GO:0046850 90 53 2,000 9,315E-03 0,05017478 ! kidney development GO:0001822 90 53 2,000 9,315E-03 0,05005754 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 9,33E-03 0,05001962 ! positive regulation of translation GO:0045727 28 18 1,000 9,33E-03 0,0499033 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 9,33E-03 0,04978751 ! pigmentation during development GO:0048066 31 18 1,000 9,33E-03 0,04967226 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 9,33E-03 0,04955755 ! prostaglandin metabolic process GO:0006693 31 18 1,000 9,33E-03 0,04944336 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 1,000 9,33E-03 0,0493297 ! cellular response to nutrient levels GO:0031669 27 18 1,000 9,33E-03 0,04921656 ! hormone transport GO:0009914 27 18 1,000 9,33E-03 0,04910393 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 9,33E-03 0,04899182 ! gut development GO:0048565 26 18 1,000 9,33E-03 0,04888022 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 9,33E-03 0,04876913 ! negative regulation of T cell activation GO:0050868 25 18 1,000 9,33E-03 0,04865854 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 9,33E-03 0,04854846 ! regulation of protein complex assembly GO:0043254 81 54 2,000 9,805E-03 0,05090557 ! DNA catabolic process GO:0006308 67 54 2,000 9,805E-03 0,05079092 ! regulation of tissue remodeling GO:0034103 91 54 2,000 9,805E-03 0,05067678 ! mesoderm development GO:0007498 76 55 2,000 0,01030941 0,05316511 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01037186 0,05336753 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01037186 0,05324841 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 0,01037186 0,05312982 ! response to alkaloid GO:0043279 32 19 1,000 0,01037186 0,05301175 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,01037186 0,05289421 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01037186 0,05277718 ! D-ribose metabolic process GO:0006014 25 19 1,000 0,01037186 0,05266068 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 0,01037186 0,05254469 ! response to starvation GO:0042594 30 19 1,000 0,01037186 0,0524292 ! response to lipopolysaccharide GO:0032496 26 19 1,000 0,01037186 0,05231423 ! plasma membrane fusion GO:0045026 23 19 1,000 0,01037186 0,05219975 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01037186 0,05208578 ! regulation of interleukin-6 production GO:0032675 22 19 1,000 0,01037186 0,0519723 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 0,01037186 0,05185932 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 0,01037186 0,05174683 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 0,01037186 0,05163482 ! protein stabilization GO:0050821 26 19 1,000 0,01037186 0,0515233 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 0,01082879 0,05367721 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 0,01082879 0,05356177 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 0,01082879 0,05344683 ! chromosome segregation GO:0007059 83 57 2,000 0,01136309 0,05596381 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 0,01136309 0,05584423 ! regulation of neurotransmitter transport GO:0051588 35 20 1,000 0,01146299 0,05621511 ! spinal cord development GO:0021510 31 20 1,000 0,01146299 0,05609551 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01146299 0,05597641 ! chromosome condensation GO:0030261 31 20 1,000 0,01146299 0,05585781 ! pallium development GO:0021543 38 20 1,000 0,01146299 0,05573972 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 0,01146299 0,05562213 ! collagen catabolic process GO:0030574 25 20 1,000 0,01146299 0,05550503 ! lung development GO:0030324 94 59 2,000 0,01247668 0,06028649 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01260228 0,06076571 ! gluconeogenesis GO:0006094 25 21 1,000 0,01260228 0,06063858 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01260228 0,06051199 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01260228 0,06038592 ! dendrite development GO:0016358 35 21 1,000 0,01260228 0,06026038 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01260228 0,06013536 ! deoxyribonucleotide metabolic process GO:0009262 27 21 1,000 0,01260228 0,06001085 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01260228 0,05988686 ! regulation of insulin secretion GO:0050796 26 21 1,000 0,01260228 0,05976339 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 0,01260228 0,05964042 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01260228 0,05951795 ! platelet activation GO:0030168 28 21 1,000 0,01260228 0,05939599 ! positive regulation of protein secretion GO:0050714 26 21 1,000 0,01260228 0,05927452 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01260228 0,05915356 ! regulation of heart contraction GO:0008016 91 60 2,000 0,01305611 0,06115897 ! meiosis GO:0007126 96 61 2,000 0,0136507 0,06381426 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 0,0136507 0,06368482 ! homeostasis of number of cells GO:0048872 84 61 2,000 0,0136507 0,0635559 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01378887 0,06406949 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 0,01378887 0,06394032 ! molting cycle process GO:0022404 40 22 1,000 0,01378887 0,06381166 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01378887 0,06368353 GO:0051297|centrosome organization, ! ureteric bud development GO:0001657 32 22 1,000 0,01378887 0,06355591 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01378887 0,06342879 ! protein tetramerization GO:0051262 39 22 1,000 0,01378887 0,06330219 ! respiratory tube development GO:0030323 99 62 2,000 0,01426051 0,06533699 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01426051 0,0652071 ! neuron fate commitment GO:0048663 32 23 1,000 0,01502192 0,06855242 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01502192 0,06841668 ! pentose metabolic process GO:0019321 31 23 1,000 0,01502192 0,06828147 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01502192 0,06814679 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01502192 0,06801264 ! myelination GO:0042552 35 23 1,000 0,01502192 0,06787902 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01502192 0,06774592 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01502192 0,06761335 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01502192 0,06748129 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01502192 0,06734975 ! respiratory system development GO:0060541 100 64 2,000 0,01552595 0,06947411 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,01630061 0,07279886 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01630061 0,07265777 ! fat cell differentiation GO:0045444 37 24 1,000 0,01630061 0,07251724 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01630061 0,07237724 ! receptor metabolic process GO:0043112 37 24 1,000 0,01630061 0,07223779 ! neural crest cell development GO:0014032 39 24 1,000 0,01630061 0,07209887 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,01630061 0,07196048 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,01630061 0,07182263 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01630061 0,0716853 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01630061 0,0715485 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,01685277 0,07383118 ! regulation of Rho protein signal transduction GO:0035023 111 66 2,000 0,01685277 0,07369081 ! peptide transport GO:0015833 43 25 1,000 0,01762412 0,07691743 ! male gonad development GO:0008584 33 25 1,000 0,01762412 0,07677175 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01762412 0,07662663 ! regulation of peptide secretion GO:0002791 34 25 1,000 0,01762412 0,07648205 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01762412 0,07633801 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01762412 0,07619452 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01762412 0,07605157 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01762412 0,07590915 ! circadian rhythm GO:0007623 42 26 1,000 0,01899165 0,08164632 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 0,01899165 0,081494 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01899165 0,08134224 ! catechol metabolic process GO:0009712 43 27 1,000 0,02040238 0,08722207 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! acute-phase response GO:0006953 42 27 1,000 0,02040238 0,08706024 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,02040238 0,08689902 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,02040238 0,0867384 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 0,02040238 0,08657836 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,02040238 0,08641892 GO:0043433|negative regulation of transcription factor activity, ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,02043985 0,08641846 ! response to hypoxia GO:0001666 132 72 2,000 0,02120371 0,08948353 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,02120371 0,08931964 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02185554 0,09189714 ! phenol metabolic process GO:0018958 44 28 1,000 0,02185554 0,09172945 ! icosanoid biosynthetic process GO:0046456 42 28 1,000 0,02185554 0,09156236 ! cell junction assembly GO:0034329 56 28 1,000 0,02185554 0,09139589 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02185554 0,09123001 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02185554 0,09106474 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,02185554 0,09090007 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02185554 0,09073599 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,02185554 0,0905725 ! placenta development GO:0001890 37 28 1,000 0,02185554 0,0904096 ! mitochondrion organization GO:0007005 104 73 2,000 0,02198307 0,09077391 ! response to oxygen levels GO:0070482 137 74 2,000 0,02277795 0,09388761 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 0,02277795 0,09371965 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,02277795 0,0935523 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,02335034 0,09573225 ! mismatch repair GO:0006298 34 29 1,000 0,02335034 0,0955619 ! telencephalon development GO:0021537 52 29 1,000 0,02335034 0,09539217 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,02335034 0,09522303 ! tissue homeostasis GO:0001894 42 29 1,000 0,02335034 0,0950545 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,02488603 0,10112697 ! collagen metabolic process GO:0032963 40 30 1,000 0,02488603 0,10094861 ! spindle organization GO:0007051 37 30 1,000 0,02488603 0,10077089 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02488603 0,10059378 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,02488603 0,1004173 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,02488603 0,10024144 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02646183 0,10640247 ! negative regulation of secretion GO:0051048 49 31 1,000 0,02646183 0,10621677 ! glial cell differentiation GO:0010001 55 31 1,000 0,02646183 0,10603173 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,02646183 0,10584732 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,02646183 0,10566356 ! segmentation GO:0035282 41 31 1,000 0,02646183 0,10548044 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02646183 0,10529794 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 1,000 0,02646183 0,10511608 ! cell fate specification GO:0001708 37 31 1,000 0,02646183 0,10493485 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,028077 0,11114821 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,028077 0,11095724 ! meiosis I GO:0007127 52 32 1,000 0,028077 0,11076691 ! peripheral nervous system development GO:0007422 53 32 1,000 0,028077 0,11057724 ! regulation of protein stability GO:0031647 48 32 1,000 0,028077 0,11038822 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,028077 0,11019985 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,028077 0,11001211 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02877593 0,11255891 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,02877593 0,1123678 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 2,000 0,0296946 0,1157586 GO:0060348|bone development, ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02973081 0,11570366 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02973081 0,11550821 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02973081 0,11531342 ! ear morphogenesis GO:0042471 42 33 1,000 0,02973081 0,11511929 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02973081 0,11492582 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02973081 0,11473299 ! female gonad development GO:0008585 49 33 1,000 0,02973081 0,1145408 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02973081 0,11434927 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,02973081 0,11415836 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02973081 0,1139681 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02973081 0,11377847 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,02973081 0,11358947 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 1,000 0,02973081 0,1134011 ! regulation of cell adhesion GO:0030155 159 83 2,000 0,03062866 0,11663231 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,03142251 0,11945749 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,03142251 0,11926036 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,03142251 0,11906389 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,03142251 0,11886806 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,03142251 0,11867287 ! female gamete generation GO:0007292 43 34 1,000 0,03142251 0,11847833 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,03254283 0,12250166 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,03254283 0,1223015 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,0331514 0,12438533 ! maintenance of protein location GO:0045185 65 35 1,000 0,0331514 0,12418275 ! glycogen metabolic process GO:0005977 48 35 1,000 0,0331514 0,12398083 ! protein homooligomerization GO:0051260 52 35 1,000 0,0331514 0,12377956 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,03491674 0,13015966 ! negative regulation of binding GO:0051100 58 36 1,000 0,03491674 0,12994905 ! tissue remodeling GO:0048771 62 36 1,000 0,03491674 0,12973912 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,03491674 0,12952986 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,03491674 0,12932128 ! glucan metabolic process GO:0044042 49 36 1,000 0,03491674 0,12911336 GO:0006073|cellular glucan metabolic process, ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,03552872 0,13116541 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,03655442 0,13473585 ! regulation of T cell activation GO:0050863 128 89 2,000 0,03655442 0,13452028 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,03671786 0,13490586 ! learning GO:0007612 67 37 1,000 0,03671786 0,1346907 ! regulation of protein secretion GO:0050708 51 37 1,000 0,03671786 0,13447623 ! gliogenesis GO:0042063 71 38 1,000 0,03855404 0,14097661 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,03855404 0,14075284 ! phagocytosis GO:0006909 60 38 1,000 0,03855404 0,14052977 ! maintenance of location in cell GO:0051651 69 38 1,000 0,03855404 0,14030742 ! response to virus GO:0009615 122 91 2,000 0,03865119 0,14043876 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04024009 0,14598141 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04024009 0,14575151 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04024009 0,14552234 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04024009 0,14529389 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04024009 0,14506616 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04024009 0,14483914 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04024009 0,14461283 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04024009 0,14438722 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04024009 0,14416232 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04024009 0,14393812 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04024009 0,14371461 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04024009 0,1434918 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04024009 0,14326968 ! tongue development GO:0043586 6 5 0,000 0,04024009 0,14304824 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04024009 0,14282749 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04024009 0,14260741 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04024009 0,14238802 ! cobalt ion transport GO:0006824 9 5 0,000 0,04024009 0,1421693 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04024009 0,14195124 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04024009 0,14173386 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04024009 0,14151714 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04024009 0,14130109 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04024009 0,14108569 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04024009 0,14087095 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04024009 0,14065686 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04024009 0,14044342 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04024009 0,14023062 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04024009 0,14001847 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04024009 0,13980697 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04024009 0,1395961 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04024009 0,13938586 ! malate metabolic process GO:0006108 7 5 0,000 0,04024009 0,13917626 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04024009 0,13896728 ! behavioral response to pain GO:0048266 7 5 0,000 0,04024009 0,13875894 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04024009 0,13855121 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04024009 0,13834411 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04024009 0,13813763 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04024009 0,13793176 ! mating behavior GO:0007617 6 5 0,000 0,04024009 0,1377265 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04024009 0,13752186 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04024009 0,13731782 ! copulation GO:0007620 7 5 0,000 0,04024009 0,13711439 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04024009 0,13691155 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04024009 0,13670932 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04024009 0,13650769 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04024009 0,13630664 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04024009 0,13610619 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04024009 0,13590633 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04024009 0,13570705 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04024009 0,13550836 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,04024009 0,13531025 ! lymph vessel development GO:0001945 7 5 0,000 0,04024009 0,13511272 ! endochondral ossification GO:0001958 12 5 0,000 0,04024009 0,13491576 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04024009 0,13471938 ! parathyroid gland development GO:0060017 8 5 0,000 0,04024009 0,13452356 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04024009 0,13432832 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04024009 0,13413364 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04024009 0,13393952 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04024009 0,13374597 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04024009 0,13355297 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04024009 0,13336053 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04024009 0,13316865 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04024009 0,13297731 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04024009 0,13278653 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04024009 0,13259629 ! ovulation GO:0030728 6 5 0,000 0,04024009 0,1324066 ! valine metabolic process GO:0006573 8 5 0,000 0,04024009 0,13221744 ! response to pH GO:0009268 9 5 0,000 0,04024009 0,13202883 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04024009 0,13184076 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04024009 0,13165322 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04024009 0,13146621 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04024009 0,13127973 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04024009 0,13109378 ! polyol catabolic process GO:0046174 7 5 0,000 0,04024009 0,13090836 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04024009 0,13072346 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04024009 0,13053908 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04024009 0,13035523 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04024009 0,13017189 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04024009 0,12998906 ! urea metabolic process GO:0019627 6 5 0,000 0,04024009 0,12980675 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04024009 0,12962495 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04024009 0,12944365 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04024009 0,12926286 ! neutrophil activation GO:0042119 5 5 0,000 0,04024009 0,12908258 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04024009 0,1289028 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04024009 0,12872352 ! response to food GO:0032094 5 5 0,000 0,04024009 0,12854474 ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04024009 0,12836645 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04024009 0,12818866 ! forebrain neuron development GO:0021884 7 5 0,000 0,04024009 0,12801136 ! melanosome organization GO:0032438 7 5 0,000 0,04024009 0,12783455 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04024009 0,12765822 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04024009 0,12748238 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04024009 0,12730703 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04024009 0,12713216 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,04024009 0,12695777 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04024009 0,12678385 ! nucleoside transport GO:0015858 6 5 0,000 0,04024009 0,12661041 ! nucleoside salvage GO:0043174 7 5 0,000 0,04024009 0,12643745 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04024009 0,12626495 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04024009 0,12609293 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04024009 0,12592138 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04024009 0,12575029 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04024009 0,12557966 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04024009 0,1254095 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04024009 0,1252398 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04024009 0,12507056 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04024009 0,12490177 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04024009 0,12473344 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04024009 0,12456556 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,04024009 0,12439813 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04024009 0,12423116 ! monocyte differentiation GO:0030224 8 5 0,000 0,04024009 0,12406463 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04024009 0,12389854 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04024009 0,1237329 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04024009 0,12356771 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04024009 0,12340295 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04024009 0,12323863 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04024009 0,12307475 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04024009 0,1229113 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04024009 0,12274829 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04024009 0,12258571 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04024009 0,12242356 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04024009 0,12226184 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04024009 0,12210054 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04024009 0,12193967 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04024009 0,12177923 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04024009 0,1216192 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04024009 0,12145959 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04024009 0,12130041 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04024009 0,12114164 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04024009 0,12098328 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04024009 0,12082534 ! neural tube patterning GO:0021532 6 5 0,000 0,04024009 0,12066781 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04024009 0,12051069 ! histone demethylation GO:0016577 9 5 0,000 0,04024009 0,12035398 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04024009 0,12019768 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04024009 0,12004178 GO:0032374|regulation of cholesterol transport, ! establishment of planar polarity GO:0001736 6 5 0,000 0,04024009 0,11988628 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04024009 0,11973119 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04024009 0,1195765 ! transcription termination GO:0006353 8 5 0,000 0,04024009 0,11942221 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04024009 0,11926831 ! plasminogen activation GO:0031639 5 5 0,000 0,04024009 0,11911481 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04024009 0,11896171 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04024009 0,118809 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04024009 0,11865668 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04024009 0,11850475 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04024009 0,11835321 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04024009 0,11820206 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04024009 0,11805129 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04024009 0,11790091 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04024009 0,1177509 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04024009 0,11760128 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04024009 0,11745204 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04024009 0,11730318 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04024009 0,1171547 ! glial cell migration GO:0008347 10 5 0,000 0,04024009 0,11700659 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04024009 0,11685885 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,04024009 0,11671149 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04024009 0,1165645 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04024009 0,11641788 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04024009 0,11627162 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04024009 0,11612574 ! neural plate development GO:0001840 6 5 0,000 0,04024009 0,11598021 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04024009 0,11583506 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04024009 0,11569026 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04024009 0,11554583 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,04024009 0,11540176 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04024009 0,11525805 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04024009 0,11511469 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04024009 0,11497169 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04024009 0,11482905 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04024009 0,11468675 ! spindle assembly GO:0051225 5 5 0,000 0,04024009 0,11454482 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04024009 0,11440323 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04024009 0,11426199 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04024009 0,1141211 ! organ regeneration GO:0031100 7 5 0,000 0,04024009 0,11398056 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04024009 0,11384036 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04024009 0,1137005 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04024009 0,113561 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04024009 0,11342183 GO:0055081|anion homeostasis, ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,0404246 0,11380243 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,0404246 0,11366331 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,0404246 0,11352452 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,0404246 0,11338608 ! synapse organization GO:0050808 55 39 1,000 0,0404246 0,11324797 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,04232887 0,11843846 ! B cell differentiation GO:0030183 62 40 1,000 0,04232887 0,11829454 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,04232887 0,11815098 ! T cell differentiation GO:0030217 65 40 1,000 0,04232887 0,11800777 ! angiogenesis GO:0001525 149 95 2,000 0,04302474 0,11980254 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,04415531 0,12280196 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,04426618 0,12296162 ! glucose transport GO:0015758 52 41 1,000 0,04426618 0,1228133 ! endosome transport GO:0016197 71 41 1,000 0,04426618 0,12266533 ! biopolymer methylation GO:0043414 62 41 1,000 0,04426618 0,12251772 ! mitochondrial transport GO:0006839 60 42 1,000 0,04623587 0,12781552 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,04623587 0,12766208 ! cellular component disassembly GO:0022411 64 42 1,000 0,04623587 0,127509 ! hexose transport GO:0008645 54 42 1,000 0,04623587 0,1273563 GO:0015749|monosaccharide transport, ! icosanoid metabolic process GO:0006690 61 42 1,000 0,04623587 0,12720396 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,04623587 0,12705198 ! tRNA transcription GO:0009304 11 6 0,000 0,04809302 0,13199756 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04809302 0,13184023 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04809302 0,13168328 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04809302 0,1315267 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04809302 0,13137049 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04809302 0,13121465 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04809302 0,13105918 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04809302 0,13090408 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04809302 0,13074935 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04809302 0,13059498 ! prostate gland development GO:0030850 9 6 0,000 0,04809302 0,13044098 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04809302 0,13028734 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04809302 0,13013406 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04809302 0,12998114 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04809302 0,12982858 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04809302 0,12967638 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04809302 0,12952453 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04809302 0,12937304 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,04809302 0,12922191 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04809302 0,12907112 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04809302 0,12892069 ! signal peptide processing GO:0006465 8 6 0,000 0,04809302 0,12877061 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04809302 0,12862087 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04809302 0,12847149 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04809302 0,12832245 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04809302 0,12817376 ! opsonization GO:0008228 8 6 0,000 0,04809302 0,12802541 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04809302 0,1278774 GO:0042069|regulation of catecholamine metabolic process, ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04809302 0,12772974 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04809302 0,12758241 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04809302 0,12743543 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04809302 0,12728878 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04809302 0,12714247 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04809302 0,1269965 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04809302 0,12685086 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04809302 0,12670556 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04809302 0,12656058 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04809302 0,12641594 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04809302 0,12627163 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04809302 0,12612765 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04809302 0,125984 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04809302 0,12584067 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04809302 0,12569767 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04809302 0,125555 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04809302 0,12541264 ! thymic T cell selection GO:0045061 12 6 0,000 0,04809302 0,12527061 ! protein lipoylation GO:0009249 10 6 0,000 0,04809302 0,1251289 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04809302 0,12498752 ! pigment granule organization GO:0048753 11 6 0,000 0,04809302 0,12484645 ! drug transport GO:0015893 6 6 0,000 0,04809302 0,12470569 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04809302 0,12456526 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04809302 0,12442514 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04809302 0,12428534 ! histidine metabolic process GO:0006547 6 6 0,000 0,04809302 0,12414585 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04809302 0,12400667 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04809302 0,12386781 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04809302 0,12372925 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04809302 0,12359101 ! adenohypophysis development GO:0021984 10 6 0,000 0,04809302 0,12345307 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04809302 0,12331544 ! hyperosmotic response GO:0006972 8 6 0,000 0,04809302 0,12317812 ! microtubule nucleation GO:0007020 10 6 0,000 0,04809302 0,1230411 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04809302 0,12290439 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04809302 0,12276798 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04809302 0,12263188 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04809302 0,12249607 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04809302 0,12236057 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04809302 0,12222536 ! response to dietary excess GO:0002021 7 6 0,000 0,04809302 0,12209045 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04809302 0,12195584 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04809302 0,12182153 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04809302 0,12168752 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04809302 0,12155379 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04809302 0,12142036 ! neuron apoptosis GO:0051402 8 6 0,000 0,04809302 0,12128723 ! organic alcohol transport GO:0015850 9 6 0,000 0,04809302 0,12115438 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04809302 0,12102183 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04809302 0,12088956 ! male sex determination GO:0030238 9 6 0,000 0,04809302 0,12075759 ! carnitine transport GO:0015879 8 6 0,000 0,04809302 0,1206259 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04809302 0,1204945 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04809302 0,12036339 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04809302 0,12023256 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04809302 0,12010201 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04809302 0,11997175 ! parturition GO:0007567 12 6 0,000 0,04809302 0,11984177 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04809302 0,11971207 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04809302 0,11958265 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04809302 0,11945351 ! spindle checkpoint GO:0031577 14 6 0,000 0,04809302 0,11932465 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04809302 0,11919607 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04809302 0,11906776 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04809302 0,11893973 ! astrocyte development GO:0014002 14 6 0,000 0,04809302 0,11881198 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04809302 0,1186845 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04809302 0,11855729 ! interaction with symbiont GO:0051702 8 6 0,000 0,04809302 0,11843035 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04809302 0,11830369 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04809302 0,1181773 ! eating behavior GO:0042755 6 6 0,000 0,04809302 0,11805118 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04809302 0,11792532 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04809302 0,11779974 ! response to copper ion GO:0046688 9 6 0,000 0,04809302 0,11767442 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04809302 0,11754936 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04809302 0,11742458 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04809302 0,11730005 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04809302 0,1171758 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04809302 0,1170518 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04809302 0,11692807 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04809302 0,11680459 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04809302 0,11668138 ! gas homeostasis GO:0033483 11 6 0,000 0,04809302 0,11655843 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04809302 0,11643574 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04809302 0,1163133 ! Schwann cell development GO:0014044 14 6 0,000 0,04809302 0,11619113 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04809302 0,1160692 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04809302 0,11594754 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04809302 0,11582613 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04809302 0,11570497 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04809302 0,11558407 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04809302 0,11546341 ! histone ubiquitination GO:0016574 7 6 0,000 0,04809302 0,11534301 ! regulation of meiosis GO:0040020 10 6 0,000 0,04809302 0,11522287 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04809302 0,11510297 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04809302 0,11498332 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04809302 0,11486392 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04809302 0,11474476 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04809302 0,11462586 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04809302 0,1145072 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04809302 0,11438878 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04809302 0,11427061 ! receptor internalization GO:0031623 9 6 0,000 0,04809302 0,11415268 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04809302 0,114035 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04809302 0,11391756 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,04809302 0,11380036 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04809302 0,1136834 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04809302 0,11356669 ! axonal fasciculation GO:0007413 9 6 0,000 0,04809302 0,11345021 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04809302 0,11333397 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04809302 0,11321796 ! midbrain development GO:0030901 6 6 0,000 0,04809302 0,1131022 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04809302 0,11298667 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04809302 0,11287138 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04809302 0,11275632 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04809302 0,1126415 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04809302 0,11252691 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04809302 0,11241255 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04809302 0,11229843 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04809302 0,11218453 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04809302 0,11207087 ! adult feeding behavior GO:0008343 6 6 0,000 0,04809302 0,11195744 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04809302 0,11184424 ! pigment granule transport GO:0051904 12 6 0,000 0,04809302 0,11173126 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04809302 0,11161852 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04809302 0,111506 ! catecholamine transport GO:0051937 7 6 0,000 0,04809302 0,11139371 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04809302 0,11128164 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04809302 0,1111698 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04809302 0,11105818 ! protein prenylation GO:0018342 10 6 0,000 0,04809302 0,11094679 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04809302 0,11083562 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04809302 0,11072468 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04809302 0,11061395 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04809302 0,11050345 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,04823729 0,11072432 ! neuromuscular process GO:0050905 79 43 1,000 0,04823729 0,11061393 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,04823729 0,11050375 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,04823729 0,1103938 ! methylation GO:0032259 64 43 1,000 0,04823729 0,11028407 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,04882455 0,11151585 ! regulation of action potential GO:0001508 71 44 1,000 0,05026979 0,1147029 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,05026979 0,11458922 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,05026979 0,11447577 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,05026979 0,11436254 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,05026979 0,11424953 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,05233275 0,11882065 ! regulation of ossification GO:0030278 71 46 1,000 0,05442553 0,12345041 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,05442553 0,12332878 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,05442553 0,12320739 ! histone modification GO:0016570 68 46 1,000 0,05442553 0,12308624 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,05442553 0,12296533 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05588214 0,12613242 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05588214 0,12600876 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05588214 0,12588534 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05588214 0,12576216 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05588214 0,12563923 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05588214 0,12551654 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05588214 0,12539408 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05588214 0,12527186 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05588214 0,12514989 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05588214 0,12502814 ! reproductive behavior GO:0019098 12 7 0,000 0,05588214 0,12490664 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05588214 0,12478537 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05588214 0,12466434 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,05588214 0,12454354 ! oligopeptide transport GO:0006857 11 7 0,000 0,05588214 0,12442297 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05588214 0,12430264 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05588214 0,12418254 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05588214 0,12406268 ! RNA methylation GO:0001510 11 7 0,000 0,05588214 0,12394304 ! pericardium development GO:0060039 8 7 0,000 0,05588214 0,12382363 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05588214 0,12370446 ! fibril organization GO:0043206 13 7 0,000 0,05588214 0,12358551 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,05588214 0,12346679 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05588214 0,1233483 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05588214 0,12323004 ! lipoprotein transport GO:0042953 9 7 0,000 0,05588214 0,123112 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05588214 0,12299419 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05588214 0,12287661 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05588214 0,12275925 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05588214 0,12264211 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05588214 0,1225252 ! chemosensory behavior GO:0007635 9 7 0,000 0,05588214 0,12240851 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05588214 0,12229204 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05588214 0,12217579 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05588214 0,12205976 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05588214 0,12194396 ! reflex GO:0060004 12 7 0,000 0,05588214 0,12182837 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05588214 0,121713 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05588214 0,12159785 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05588214 0,12148292 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05588214 0,12136821 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05588214 0,12125371 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05588214 0,12113943 ! spinal cord patterning GO:0021511 7 7 0,000 0,05588214 0,12102536 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05588214 0,12091151 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05588214 0,12079787 ! adrenal gland development GO:0030325 17 7 0,000 0,05588214 0,12068444 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05588214 0,12057123 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05588214 0,12045823 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05588214 0,12034544 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05588214 0,12023286 ! endosome organization GO:0007032 10 7 0,000 0,05588214 0,1201205 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05588214 0,12000834 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05588214 0,11989639 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05588214 0,11978465 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05588214 0,11967312 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05588214 0,1195618 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05588214 0,11945068 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05588214 0,11933977 ! galactose metabolic process GO:0006012 10 7 0,000 0,05588214 0,11922907 ! vesicle fusion GO:0006906 15 7 0,000 0,05588214 0,11911857 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05588214 0,11900827 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,05588214 0,11889818 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05588214 0,11878829 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05588214 0,11867861 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05588214 0,11856913 ! retinol metabolic process GO:0042572 9 7 0,000 0,05588214 0,11845985 ! behavioral fear response GO:0001662 13 7 0,000 0,05588214 0,11835077 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05588214 0,11824189 ! rRNA modification GO:0000154 12 7 0,000 0,05588214 0,11813321 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05588214 0,11802473 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05588214 0,11791645 ! response to UV-B GO:0010224 11 7 0,000 0,05588214 0,11780837 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05588214 0,11770049 ! intermediate filament organization GO:0045109 11 7 0,000 0,05588214 0,1175928 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05588214 0,11748531 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05588214 0,11737802 ! fibrinolysis GO:0042730 9 7 0,000 0,05588214 0,11727092 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05588214 0,11716402 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05588214 0,11705732 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05588214 0,1169508 ! response to tropane GO:0014073 13 7 0,000 0,05588214 0,11684448 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05588214 0,11673836 ! melanosome localization GO:0032400 10 7 0,000 0,05588214 0,11663242 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05588214 0,11652668 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05588214 0,11642113 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05588214 0,11631578 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05588214 0,11621061 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05588214 0,11610563 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05588214 0,11600084 ! mast cell activation GO:0045576 9 7 0,000 0,05588214 0,11589624 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05588214 0,11579183 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05588214 0,11568761 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05588214 0,11558357 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05588214 0,11547972 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05588214 0,11537606 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05588214 0,11527258 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05588214 0,11516929 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05588214 0,11506619 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05588214 0,11496327 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05588214 0,11486053 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05588214 0,11475798 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05588214 0,1146556 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,05588214 0,11455342 ! diuresis GO:0030146 12 7 0,000 0,05588214 0,11445141 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05588214 0,11434958 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05588214 0,11424794 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05588214 0,11414648 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05588214 0,11404519 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05588214 0,11394409 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05588214 0,11384316 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05588214 0,11374242 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05588214 0,11364185 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05588214 0,11354146 ! lymph node development GO:0048535 9 7 0,000 0,05588214 0,11344125 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05588214 0,11334121 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05588214 0,11324135 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05588214 0,11314167 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05588214 0,11304216 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05588214 0,11294282 ! ATP catabolic process GO:0006200 10 7 0,000 0,05588214 0,11284366 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05588214 0,11274468 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05588214 0,11264587 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05588214 0,11254723 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05588214 0,11244876 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05588214 0,11235047 ! muscle adaptation GO:0043500 12 7 0,000 0,05588214 0,11225234 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05588214 0,11215439 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05588214 0,11205661 ! retina homeostasis GO:0001895 9 7 0,000 0,05588214 0,111959 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05588214 0,11186156 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05588214 0,11176429 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05588214 0,11166719 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05588214 0,11157025 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05588214 0,11147349 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05588214 0,11137689 ! endocrine system development GO:0035270 83 47 1,000 0,05654751 0,11260543 ! covalent chromatin modification GO:0016569 75 47 1,000 0,05654751 0,11250802 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,05654751 0,11241078 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,05654751 0,11231371 ! response to temperature stimulus GO:0009266 62 48 1,000 0,05869809 0,11648457 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,05869809 0,11638415 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,05869809 0,1162839 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,05869809 0,11618383 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,06087667 0,12039238 ! maintenance of location GO:0051235 84 49 1,000 0,06087667 0,12028895 ! ear development GO:0043583 72 50 1,000 0,06308264 0,12454084 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,06308264 0,12443403 ! lipid modification GO:0030258 73 50 1,000 0,06308264 0,1243274 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06360797 0,12525543 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06360797 0,12514828 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,06360797 0,12504131 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,06360797 0,12493453 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06360797 0,12482793 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06360797 0,12472152 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06360797 0,12461528 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06360797 0,12450922 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06360797 0,12440335 ! phosphate transport GO:0006817 10 8 0,000 0,06360797 0,12429765 ! N-glycan processing GO:0006491 12 8 0,000 0,06360797 0,12419214 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06360797 0,1240868 ! UTP metabolic process GO:0046051 8 8 0,000 0,06360797 0,12398164 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06360797 0,12387666 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06360797 0,12377186 ! succinate metabolic process GO:0006105 14 8 0,000 0,06360797 0,12366723 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,06360797 0,12356279 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06360797 0,12345851 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06360797 0,12335442 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06360797 0,1232505 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06360797 0,12314675 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06360797 0,12304318 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06360797 0,12293978 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06360797 0,12283656 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06360797 0,1227335 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06360797 0,12263063 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06360797 0,12252792 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06360797 0,12242539 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06360797 0,12232302 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06360797 0,12222083 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06360797 0,12211881 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06360797 0,12201696 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06360797 0,12191528 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06360797 0,12181377 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06360797 0,12171243 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06360797 0,12161125 ! melanin metabolic process GO:0006582 12 8 0,000 0,06360797 0,12151025 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06360797 0,12140941 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06360797 0,12130874 ! macrophage activation GO:0042116 12 8 0,000 0,06360797 0,12120823 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06360797 0,1211079 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06360797 0,12100772 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06360797 0,12090772 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06360797 0,12080788 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06360797 0,1207082 ! ruffle organization GO:0031529 11 8 0,000 0,06360797 0,12060869 ! osteoblast development GO:0002076 13 8 0,000 0,06360797 0,12050934 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06360797 0,12041015 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06360797 0,12031113 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06360797 0,12021227 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06360797 0,12011358 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06360797 0,12001504 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06360797 0,11991667 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06360797 0,11981846 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06360797 0,11972041 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06360797 0,11962252 ! brain morphogenesis GO:0048854 20 8 0,000 0,06360797 0,11952479 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06360797 0,11942721 ! segment specification GO:0007379 10 8 0,000 0,06360797 0,1193298 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,06360797 0,11923255 ! cellular extravasation GO:0045123 11 8 0,000 0,06360797 0,11913545 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06360797 0,11903852 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06360797 0,11894174 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06360797 0,11884512 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06360797 0,11874865 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06360797 0,11865234 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,06360797 0,11855619 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06360797 0,11846019 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,06360797 0,11836435 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06360797 0,11826866 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06360797 0,11817313 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06360797 0,11807775 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06360797 0,11798253 ! icosanoid secretion GO:0032309 12 8 0,000 0,06360797 0,11788746 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06360797 0,11779254 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06360797 0,11769778 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06360797 0,11760317 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06360797 0,1175087 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06360797 0,1174144 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06360797 0,11732024 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06360797 0,11722623 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06360797 0,11713238 ! sterol catabolic process GO:0016127 9 8 0,000 0,06360797 0,11703867 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06360797 0,11694511 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06360797 0,11685171 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06360797 0,11675845 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06360797 0,11666534 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06360797 0,11657238 ! prophase GO:0051324 11 8 0,000 0,06360797 0,11647957 ! S phase GO:0051320 8 8 0,000 0,06360797 0,1163869 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06360797 0,11629439 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,06360797 0,11620202 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06360797 0,11610979 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06360797 0,11601771 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06360797 0,11592578 ! hormone catabolic process GO:0042447 13 8 0,000 0,06360797 0,115834 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06360797 0,11574236 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06360797 0,11565086 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06360797 0,11555951 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06360797 0,1154683 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06360797 0,11537724 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06360797 0,11528632 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06360797 0,11519554 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06360797 0,11510491 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06360797 0,11501442 ! regulation of embryonic development GO:0045995 16 8 0,000 0,06360797 0,11492407 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06360797 0,11483386 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06360797 0,11474379 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,06531543 0,11773157 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,06531543 0,11763938 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,06531543 0,11754733 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,06757445 0,12151777 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,06985913 0,12552813 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,07127102 0,12796514 ! regulation of developmental growth GO:0048638 13 9 0,000 0,07127102 0,12786532 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,07127102 0,12776566 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07127102 0,12766615 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07127102 0,1275668 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07127102 0,12746761 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07127102 0,12736856 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,07127102 0,12726968 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,07127102 0,12717094 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07127102 0,12707236 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07127102 0,12697393 ! GTP metabolic process GO:0046039 9 9 0,000 0,07127102 0,12687565 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07127102 0,12677753 ! social behavior GO:0035176 14 9 0,000 0,07127102 0,12667955 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07127102 0,12658173 ! artery development GO:0060840 19 9 0,000 0,07127102 0,12648406 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,07127102 0,12638654 ! regulation of glycolysis GO:0006110 15 9 0,000 0,07127102 0,12628917 ! response to pain GO:0048265 16 9 0,000 0,07127102 0,12619195 ! protein complex disassembly GO:0043241 17 9 0,000 0,07127102 0,12609488 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,07127102 0,12599796 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07127102 0,12590118 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07127102 0,12580456 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07127102 0,12570808 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,07127102 0,12561176 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07127102 0,12551558 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07127102 0,12541954 ! protein targeting to ER GO:0045047 19 9 0,000 0,07127102 0,12532366 ! T cell selection GO:0045058 18 9 0,000 0,07127102 0,12522792 ! endoderm development GO:0007492 12 9 0,000 0,07127102 0,12513232 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07127102 0,12503687 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07127102 0,12494157 ! arginine catabolic process GO:0006527 10 9 0,000 0,07127102 0,12484641 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,07127102 0,1247514 GO:0010833|telomere maintenance via telomere lengthening, ! phosphagen metabolic process GO:0006599 12 9 0,000 0,07127102 0,12465653 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,07127102 0,12456181 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07127102 0,12446723 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07127102 0,12437279 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07127102 0,1242785 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07127102 0,12418435 ! mannose metabolic process GO:0006013 9 9 0,000 0,07127102 0,12409034 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,07127102 0,12399648 ! epithelial cell development GO:0002064 10 9 0,000 0,07127102 0,12390275 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07127102 0,12380917 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07127102 0,12371573 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,07127102 0,12362243 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07127102 0,12352927 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07127102 0,12343625 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,07127102 0,12334337 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07127102 0,12325063 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07127102 0,12315803 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07127102 0,12306557 ! response to amine stimulus GO:0014075 13 9 0,000 0,07127102 0,12297325 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07127102 0,12288107 ! renal water homeostasis GO:0003091 14 9 0,000 0,07127102 0,12278902 ! mRNA cleavage GO:0006379 13 9 0,000 0,07127102 0,12269711 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07127102 0,12260534 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07127102 0,12251371 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07127102 0,12242221 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07127102 0,12233085 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07127102 0,12223963 ! acid secretion GO:0046717 14 9 0,000 0,07127102 0,12214854 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07127102 0,12205759 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07127102 0,12196677 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07127102 0,12187609 ! purine base metabolic process GO:0006144 18 9 0,000 0,07127102 0,12178554 ! thymus development GO:0048538 15 9 0,000 0,07127102 0,12169513 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07127102 0,12160485 ! spleen development GO:0048536 15 9 0,000 0,07127102 0,12151471 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07127102 0,1214247 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07127102 0,12133482 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07127102 0,12124508 ! detection of calcium ion GO:0005513 13 9 0,000 0,07127102 0,12115546 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07127102 0,12106598 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07127102 0,12097664 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07127102 0,12088742 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,07127102 0,12079834 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07127102 0,12070938 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07127102 0,12062056 ! prepulse inhibition GO:0060134 14 9 0,000 0,07127102 0,12053187 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07127102 0,12044331 ! insulin secretion GO:0030073 17 9 0,000 0,07127102 0,12035488 ! sequestering of metal ion GO:0051238 11 9 0,000 0,07127102 0,12026658 ! response to nicotine GO:0035094 16 9 0,000 0,07127102 0,1201784 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07127102 0,12009036 ! regulation of synapse organization GO:0050807 12 9 0,000 0,07127102 0,12000245 ! regulation of mitosis GO:0007088 84 54 1,000 0,07216891 0,12142538 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,07216891 0,12133662 ! detection of external stimulus GO:0009581 66 54 1,000 0,07216891 0,12124799 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,07216891 0,12115948 ! exocytosis GO:0006887 74 55 1,000 0,07450323 0,12498719 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07887179 0,13221947 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07887179 0,13212317 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07887179 0,13202701 ! thyroid gland development GO:0030878 19 10 0,000 0,07887179 0,13193099 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07887179 0,13183511 ! synapsis GO:0007129 13 10 0,000 0,07887179 0,13173937 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07887179 0,13164377 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07887179 0,1315483 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07887179 0,13145298 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07887179 0,13135779 ! sulfate transport GO:0008272 12 10 0,000 0,07887179 0,13126274 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07887179 0,13116783 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,07887179 0,13107306 ! phospholipid efflux GO:0033700 16 10 0,000 0,07887179 0,13097842 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07887179 0,13088392 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07887179 0,13078955 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07887179 0,13069533 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07887179 0,13060123 ! pathogenesis GO:0009405 13 10 0,000 0,07887179 0,13050728 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07887179 0,13041345 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07887179 0,13031976 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07887179 0,13022621 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07887179 0,13013279 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07887179 0,13003951 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07887179 0,12994636 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07887179 0,12985334 ! B cell proliferation GO:0042100 14 10 0,000 0,07887179 0,12976045 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07887179 0,1296677 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07887179 0,12957508 ! forebrain cell migration GO:0021885 17 10 0,000 0,07887179 0,12948259 ! lipid digestion GO:0044241 15 10 0,000 0,07887179 0,12939024 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07887179 0,12929801 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07887179 0,12920592 ! UV protection GO:0009650 14 10 0,000 0,07887179 0,12911396 ! entry into host cell GO:0030260 20 10 0,000 0,07887179 0,12902213 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07887179 0,12893043 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07887179 0,12883886 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07887179 0,12874742 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07887179 0,12865611 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07887179 0,12856493 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07887179 0,12847388 ! regulation of organ growth GO:0046620 11 10 0,000 0,07887179 0,12838295 ! response to dsRNA GO:0043331 18 10 0,000 0,07887179 0,12829216 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07887179 0,12820149 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07887179 0,12811096 ! embryonic axis specification GO:0000578 12 10 0,000 0,07887179 0,12802055 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07887179 0,12793026 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07887179 0,12784011 ! cranial nerve development GO:0021545 12 10 0,000 0,07887179 0,12775008 ! fucose catabolic process GO:0019317 16 10 0,000 0,07887179 0,12766018 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07887179 0,1275704 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07887179 0,12748075 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07887179 0,12739123 ! zymogen activation GO:0031638 14 10 0,000 0,07887179 0,12730183 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07887179 0,12721256 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07887179 0,12712341 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07887179 0,12703439 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07887179 0,1269455 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07887179 0,12685672 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07887179 0,12676807 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07887179 0,12667955 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07887179 0,12659115 ! detection of bacterium GO:0016045 10 10 0,000 0,07887179 0,12650287 ! embryonic gut development GO:0048566 11 10 0,000 0,07887179 0,12641471 ! activation of innate immune response GO:0002218 10 10 0,000 0,07887179 0,12632668 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07887179 0,12623877 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07887179 0,12615098 ! developmental induction GO:0031128 13 10 0,000 0,07887179 0,12606332 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07887179 0,12597577 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07887179 0,12588835 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07887179 0,12580105 ! carbohydrate transport GO:0008643 74 57 1,000 0,07924331 0,12630603 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,07924331 0,12621856 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,07924331 0,12613121 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,08164798 0,12986885 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,08164798 0,1297791 ! rRNA transcription GO:0009303 17 11 0,000 0,08641078 0,1372547 ! respiratory burst GO:0045730 14 11 0,000 0,08641078 0,13715997 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08641078 0,13706538 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08641078 0,13697092 ! virus-host interaction GO:0019048 17 11 0,000 0,08641078 0,13687659 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08641078 0,13678238 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08641078 0,13668831 ! mating GO:0007618 14 11 0,000 0,08641078 0,13659437 ! T cell proliferation GO:0042098 20 11 0,000 0,08641078 0,13650055 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08641078 0,13640687 ! bone resorption GO:0045453 16 11 0,000 0,08641078 0,13631331 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08641078 0,13621988 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08641078 0,13612658 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! syncytium formation GO:0006949 15 11 0,000 0,08641078 0,1360334 ! plasma membrane organization GO:0007009 18 11 0,000 0,08641078 0,13594036 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08641078 0,13584744 ! mitotic spindle organization GO:0007052 15 11 0,000 0,08641078 0,13575465 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08641078 0,13566198 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08641078 0,13556944 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08641078 0,13547703 ! adult heart development GO:0007512 11 11 0,000 0,08641078 0,13538474 ! temperature homeostasis GO:0001659 16 11 0,000 0,08641078 0,13529258 ! L-glutamate transport GO:0015813 16 11 0,000 0,08641078 0,13520055 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08641078 0,13510864 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08641078 0,13501685 ! stem cell development GO:0048864 29 11 0,000 0,08641078 0,13492519 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08641078 0,13483365 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08641078 0,13474224 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08641078 0,13465095 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08641078 0,13455979 ! vasoconstriction GO:0042310 15 11 0,000 0,08641078 0,13446874 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08641078 0,13437782 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08641078 0,13428703 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08641078 0,13419636 ! ribosome assembly GO:0042255 13 11 0,000 0,08641078 0,1341058 ! histone deacetylation GO:0016575 13 11 0,000 0,08641078 0,13401538 ! chromatin silencing GO:0006342 19 11 0,000 0,08641078 0,13392507 ! nucleosome positioning GO:0016584 13 11 0,000 0,08641078 0,13383488 ! T cell homeostasis GO:0043029 20 11 0,000 0,08641078 0,13374482 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08641078 0,13365488 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08641078 0,13356506 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08641078 0,13347535 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08641078 0,13338577 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08641078 0,13329631 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08641078 0,13320697 ! male genitalia development GO:0030539 13 11 0,000 0,08641078 0,13311775 ! cholesterol efflux GO:0033344 19 11 0,000 0,08641078 0,13302865 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,08641078 0,13293967 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08641078 0,1328508 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08641078 0,13276206 ! germ cell migration GO:0008354 18 11 0,000 0,08641078 0,13267343 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08641078 0,13258493 ! defense response to fungus GO:0050832 12 11 0,000 0,08641078 0,13249654 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08641078 0,13240826 ! lysogeny GO:0030069 18 11 0,000 0,08641078 0,13232011 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08641078 0,13223207 ! acrosome reaction GO:0007340 13 11 0,000 0,08641078 0,13214415 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08641078 0,13205635 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,08652397 0,13214153 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,08652397 0,13205384 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,08652397 0,13196627 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 92 61 1,000 0,08899425 0,13564399 ! lactation GO:0007595 20 12 0,000 0,0938885 0,14300898 ! reproductive cellular process GO:0048610 14 12 0,000 0,0938885 0,14291434 ! tRNA modification GO:0006400 14 12 0,000 0,0938885 0,14281981 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,0938885 0,14272542 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,0938885 0,14263115 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,0938885 0,142537 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,0938885 0,14244298 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,0938885 0,14234908 ! non-recombinational repair GO:0000726 19 12 0,000 0,0938885 0,14225531 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,0938885 0,14216166 ! peroxisomal transport GO:0043574 21 12 0,000 0,0938885 0,14206813 ! cartilage condensation GO:0001502 18 12 0,000 0,0938885 0,14197473 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,0938885 0,14188145 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,0938885 0,14178829 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,0938885 0,14169525 ! heart looping GO:0001947 15 12 0,000 0,0938885 0,14160233 ! palate development GO:0060021 15 12 0,000 0,0938885 0,14150954 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,0938885 0,14141687 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,0938885 0,14132432 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,0938885 0,14123189 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,0938885 0,14113958 ! arginine metabolic process GO:0006525 13 12 0,000 0,0938885 0,14104739 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,0938885 0,14095533 ! methionine metabolic process GO:0006555 13 12 0,000 0,0938885 0,14086338 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,0938885 0,14077155 ! Golgi organization GO:0007030 18 12 0,000 0,0938885 0,14067984 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,0938885 0,14058826 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,0938885 0,14049679 ! monoamine transport GO:0015844 13 12 0,000 0,0938885 0,14040544 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0938885 0,1403142 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,0938885 0,14022309 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,0938885 0,1401321 ! L-amino acid transport GO:0015807 20 12 0,000 0,0938885 0,14004122 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,0938885 0,13995046 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,0938885 0,13985982 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,0938885 0,13976929 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,0938885 0,13967889 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,0938885 0,1395886 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,0938885 0,13949842 ! cerebellum development GO:0021549 13 12 0,000 0,0938885 0,13940837 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,0938885 0,13931843 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,0938885 0,1392286 ! histone methylation GO:0016571 15 12 0,000 0,0938885 0,13913889 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,0938885 0,1390493 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,0938885 0,13895982 ! regulation of epidermis development GO:0045682 17 12 0,000 0,0938885 0,13887046 ! intestinal absorption GO:0050892 19 12 0,000 0,0938885 0,13878121 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,0938885 0,13869207 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,0938885 0,13860306 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,0938885 0,13851415 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,0938885 0,13842536 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,0938885 0,13833668 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,0938885 0,13824812 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,09399685 0,1383191 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,09399685 0,13823066 ! viral reproduction GO:0016032 92 63 1,000 0,09399685 0,13814233 ! regulation of lipase activity GO:0060191 109 63 1,000 0,09399685 0,13805412 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,09652817 0,14168142 ! appendage morphogenesis GO:0035107 93 64 1,000 0,09652817 0,14159106 GO:0035108|limb morphogenesis, ! adaptive immune response GO:0002250 94 64 1,000 0,09652817 0,14150082 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 1,000 0,09907885 0,14514736 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,09907885 0,14505497 ! defense response to bacterium GO:0042742 73 65 1,000 0,09907885 0,14496269 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,09907885 0,14487054 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,09907885 0,1447785 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,10130544 0,14793811 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,10130544 0,14784424 ! cGMP metabolic process GO:0046068 16 13 0,000 0,10130544 0,14775049 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,10130544 0,14765686 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,10130544 0,14756335 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,10130544 0,14746995 ! lipid localization GO:0010876 24 13 0,000 0,10130544 0,14737667 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,10130544 0,14728352 ! organelle fusion GO:0048284 28 13 0,000 0,10130544 0,14719048 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,10130544 0,14709755 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,10130544 0,14700475 ! response to hexose stimulus GO:0009746 19 13 0,000 0,10130544 0,14691206 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,10130544 0,14681948 ! glutamate metabolic process GO:0006536 18 13 0,000 0,10130544 0,14672703 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,10130544 0,14663469 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,10130544 0,14654247 ! NAD metabolic process GO:0019674 21 13 0,000 0,10130544 0,14645036 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,10130544 0,14635837 ! regulation of exocytosis GO:0017157 17 13 0,000 0,10130544 0,14626649 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,10130544 0,14617473 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,10130544 0,14608309 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,10130544 0,14599156 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,10130544 0,14590014 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,10130544 0,14580884 ! genitalia development GO:0048806 15 13 0,000 0,10130544 0,14571765 ! tissue regeneration GO:0042246 21 13 0,000 0,10130544 0,14562658 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,10130544 0,14553562 ! cofactor transport GO:0051181 19 13 0,000 0,10130544 0,14544477 ! NADP metabolic process GO:0006739 18 13 0,000 0,10130544 0,14535404 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,10130544 0,14526342 ! gas transport GO:0015669 18 13 0,000 0,10130544 0,14517291 ! heme biosynthetic process GO:0006783 20 13 0,000 0,10130544 0,14508252 ! regulation of axon extension GO:0030516 23 13 0,000 0,10130544 0,14499224 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,10130544 0,14490207 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,10130544 0,14481201 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,10130544 0,14472206 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,10130544 0,14463223 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,10130544 0,14454251 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,10130544 0,1444529 ! axon guidance GO:0007411 99 66 1,000 0,10164842 0,14485214 ! regulation of immune effector process GO:0002697 101 66 1,000 0,10164842 0,14476245 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,10423639 0,14835625 ! acute inflammatory response GO:0002526 92 68 1,000 0,1068423 0,15197112 ! learning or memory GO:0007611 123 68 1,000 0,1068423 0,15187719 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,1068423 0,15178338 ! rhythmic process GO:0048511 105 68 1,000 0,1068423 0,15168969 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,10866209 0,15417817 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,10866209 0,15408312 ! superoxide anion generation GO:0042554 18 14 0,000 0,10866209 0,15398818 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10866209 0,15389336 ! myotube differentiation GO:0014902 21 14 0,000 0,10866209 0,15379866 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,10866209 0,15370407 ! inositol metabolic process GO:0006020 20 14 0,000 0,10866209 0,1536096 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10866209 0,15351524 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10866209 0,15342101 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10866209 0,15332688 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10866209 0,15323287 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10866209 0,15313898 ! response to cAMP GO:0051591 19 14 0,000 0,10866209 0,1530452 ! startle response GO:0001964 21 14 0,000 0,10866209 0,15295154 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,10866209 0,15285799 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10866209 0,15276456 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10866209 0,15267124 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10866209 0,15257803 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,10866209 0,15248494 ! glycine metabolic process GO:0006544 22 14 0,000 0,10866209 0,15239196 ! pituitary gland development GO:0021983 23 14 0,000 0,10866209 0,1522991 ! lysosomal transport GO:0007041 20 14 0,000 0,10866209 0,15220634 ! regulation of heart rate GO:0002027 23 14 0,000 0,10866209 0,15211371 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10866209 0,15202118 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10866209 0,15192876 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,10866209 0,15183646 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,10866209 0,15174427 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10866209 0,1516522 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,10866209 0,15156023 ! axon cargo transport GO:0008088 27 14 0,000 0,10866209 0,15146837 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10866209 0,15137663 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,10866209 0,151285 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,10866209 0,15119348 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10866209 0,15110207 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10866209 0,15101077 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10866209 0,15091958 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10866209 0,1508285 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10866209 0,15073753 ! muscle maintenance GO:0046716 19 14 0,000 0,10866209 0,15064667 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,10866209 0,15055591 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10866209 0,15046527 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10866209 0,15037474 ! cell killing GO:0001906 20 14 0,000 0,10866209 0,15028432 ! cilium assembly GO:0042384 20 14 0,000 0,10866209 0,150194 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,11210611 0,1548613 ! humoral immune response GO:0006959 86 70 1,000 0,11210611 0,15476835 ! eye development GO:0001654 111 70 1,000 0,11210611 0,1546755 ! muscle cell differentiation GO:0042692 104 71 1,000 0,11476311 0,15824649 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,11476311 0,15815168 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,11476311 0,15805698 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,11595894 0,15960836 ! positive regulation of cell size GO:0045793 20 15 0,000 0,11595894 0,1595129 ! metencephalon development GO:0022037 19 15 0,000 0,11595894 0,15941755 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,11595894 0,15932232 ! skin development GO:0043588 25 15 0,000 0,11595894 0,1592272 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,11595894 0,1591322 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,11595894 0,15903731 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,11595894 0,15894253 ! bile acid metabolic process GO:0008206 22 15 0,000 0,11595894 0,15884787 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,11595894 0,15875331 ! adult walking behavior GO:0007628 25 15 0,000 0,11595894 0,15865887 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,11595894 0,15856455 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,11595894 0,15847033 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,11595894 0,15837623 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,11595894 0,15828223 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,11595894 0,15818835 ! cerebral cortex development GO:0021987 29 15 0,000 0,11595894 0,15809459 ! response to osmotic stress GO:0006970 22 15 0,000 0,11595894 0,15800093 ! vesicle coating GO:0006901 25 15 0,000 0,11595894 0,15790738 ! DNA integration GO:0015074 22 15 0,000 0,11595894 0,15781394 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,11595894 0,15772062 ! regulation of vasodilation GO:0042312 24 15 0,000 0,11595894 0,1576274 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,11595894 0,1575343 ! neuron recognition GO:0008038 22 15 0,000 0,11595894 0,1574413 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,11595894 0,15734842 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,11595894 0,15725564 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,11595894 0,15716297 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,11595894 0,15707042 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,11595894 0,15697797 ! organic cation transport GO:0015695 19 15 0,000 0,11595894 0,15688563 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,11595894 0,1567934 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,11595894 0,15670127 ! peptide hormone processing GO:0016486 19 15 0,000 0,11595894 0,15660926 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,11743623 0,15851135 ! regulation of blood pressure GO:0008217 107 73 1,000 0,12012506 0,16204553 ! tube morphogenesis GO:0035239 118 73 1,000 0,12012506 0,16195054 ! protein import into nucleus GO:0006606 118 74 1,000 0,12282914 0,16549914 ! protein secretion GO:0009306 27 16 0,000 0,12319647 0,16589688 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,12319647 0,16579981 ! bone remodeling GO:0046849 24 16 0,000 0,12319647 0,16570285 ! endothelial cell migration GO:0043542 22 16 0,000 0,12319647 0,16560601 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,12319647 0,16550927 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,12319647 0,16541265 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,12319647 0,16531615 ! glial cell development GO:0021782 24 16 0,000 0,12319647 0,16521975 ! patterning of blood vessels GO:0001569 24 16 0,000 0,12319647 0,16512347 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,12319647 0,1650273 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,12319647 0,16493124 ! protein polyubiquitination GO:0000209 26 16 0,000 0,12319647 0,1648353 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,12319647 0,16473946 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,12319647 0,16464374 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,12319647 0,16454813 ! fructose metabolic process GO:0006000 20 16 0,000 0,12319647 0,16445263 ! regulation of protein binding GO:0043393 27 16 0,000 0,12319647 0,16435724 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,12319647 0,16426196 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,12319647 0,16416679 ! protein export from nucleus GO:0006611 24 16 0,000 0,12319647 0,16407173 ! negative regulation of immune response GO:0050777 28 16 0,000 0,12319647 0,16397678 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,12319647 0,16388194 ! DNA replication initiation GO:0006270 25 16 0,000 0,12319647 0,16378721 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,12319647 0,16369259 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,12319647 0,16359808 ! diencephalon development GO:0021536 25 16 0,000 0,12319647 0,16350368 ! G1 phase GO:0051318 27 16 0,000 0,12319647 0,16340939 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,12319647 0,1633152 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,12319647 0,16322113 ! steroid catabolic process GO:0006706 22 16 0,000 0,12319647 0,16312716 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,12319647 0,1630333 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,12319647 0,16293955 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,12319647 0,16284591 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,12319647 0,16275237 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,12319647 0,16265894 ! sperm-egg recognition GO:0035036 16 16 0,000 0,12319647 0,16256562 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,12319647 0,16247241 ! nerve development GO:0021675 18 16 0,000 0,12319647 0,1623793 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,12319647 0,1622863 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,12319647 0,1621934 ! negative regulation of translation GO:0017148 22 16 0,000 0,12319647 0,16210062 ! blood coagulation GO:0007596 116 75 1,000 0,12554807 0,16510037 GO:0050817|coagulation, ! nuclear import GO:0051170 121 75 1,000 0,12554807 0,16500603 ! amine biosynthetic process GO:0009309 97 76 1,000 0,12828141 0,16850214 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,13037515 0,1711546 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,13037515 0,17105696 ! negative regulation of defense response GO:0031348 19 17 0,000 0,13037515 0,17095944 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,13037515 0,17086202 ! glycerol metabolic process GO:0006071 20 17 0,000 0,13037515 0,17076472 ! zinc ion transport GO:0006829 20 17 0,000 0,13037515 0,17066753 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,13037515 0,17057045 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,13037515 0,17047348 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,13037515 0,17037662 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,13037515 0,17027987 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,13037515 0,17018323 ! memory GO:0007613 25 17 0,000 0,13037515 0,1700867 ! keratinization GO:0031424 17 17 0,000 0,13037515 0,16999028 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,13037515 0,16989397 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,13037515 0,16979776 ! retinoid metabolic process GO:0001523 22 17 0,000 0,13037515 0,16970167 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,13037515 0,16960568 ! vacuolar transport GO:0007034 24 17 0,000 0,13037515 0,16950981 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,13037515 0,16941404 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,13037515 0,16931838 ! membrane budding GO:0006900 29 17 0,000 0,13037515 0,16922283 ! heme metabolic process GO:0042168 27 17 0,000 0,13037515 0,16912738 ! body fluid secretion GO:0007589 27 17 0,000 0,13037515 0,16903205 ! stem cell differentiation GO:0048863 36 17 0,000 0,13037515 0,16893682 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,13037515 0,1688417 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,13037515 0,16874668 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,13037515 0,16865177 ! sensory perception of pain GO:0019233 23 17 0,000 0,13037515 0,16855697 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,13037515 0,16846228 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,13037515 0,16836769 ! synaptogenesis GO:0007416 24 17 0,000 0,13037515 0,1682732 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,13037515 0,16817883 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,13037515 0,16808456 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,13037515 0,16799039 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,13037515 0,16789633 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,13037515 0,16780238 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,13102877 0,16854931 ! protein ubiquitination GO:0016567 125 77 1,000 0,13102877 0,1684551 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,13102877 0,16836099 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,13102877 0,16826698 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,13102877 0,16817309 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,13378972 0,17162095 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,13656388 0,17508189 ! T cell activation GO:0042110 134 79 1,000 0,13656388 0,17498435 ! regulation of lyase activity GO:0051339 133 79 1,000 0,13656388 0,17488692 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,13749547 0,17598196 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,13749547 0,17588408 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,13749547 0,17578632 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,13749547 0,17568866 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13749547 0,17559111 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13749547 0,17549366 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13749547 0,17539633 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13749547 0,1752991 ! axis specification GO:0009798 26 18 0,000 0,13749547 0,17520198 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13749547 0,17510497 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,13749547 0,17500807 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13749547 0,17491127 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13749547 0,17481458 ! central nervous system neuron development GO:0021954 30 18 0,000 0,13749547 0,174718 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13749547 0,17462153 ! fucose metabolic process GO:0006004 26 18 0,000 0,13749547 0,17452516 ! response to fungus GO:0009620 19 18 0,000 0,13749547 0,17442889 ! peptide cross-linking GO:0018149 31 18 0,000 0,13749547 0,17433274 ! heart process GO:0003015 27 18 0,000 0,13749547 0,17423668 GO:0060047|heart contraction, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,13749547 0,17414074 ! visual learning GO:0008542 35 18 0,000 0,13749547 0,1740449 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13749547 0,17394916 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13749547 0,17385354 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,13749547 0,17375801 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13749547 0,17366259 ! vitamin transport GO:0051180 24 18 0,000 0,13749547 0,17356728 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,13749547 0,17347207 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13749547 0,17337696 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,13749547 0,17328196 ! cell-cell recognition GO:0009988 20 18 0,000 0,13749547 0,17318707 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13749547 0,17309227 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13749547 0,17299758 ! protein localization in nucleus GO:0034504 133 80 1,000 0,13935083 0,17523614 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,13935083 0,17514039 ! forebrain development GO:0030900 131 80 1,000 0,13935083 0,17504473 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,14215019 0,17846367 ! hemostasis GO:0007599 125 81 1,000 0,14215019 0,17836631 ! regulation of neurological system process GO:0031644 122 81 1,000 0,14215019 0,17826905 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,14455789 0,18118973 ! positive regulation of ossification GO:0045778 30 19 0,000 0,14455789 0,18109104 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,14455789 0,18099246 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,14455789 0,18089399 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,14455789 0,18079562 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,14455789 0,18069737 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,14455789 0,18059921 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,14455789 0,18050117 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,14455789 0,18040323 ! regeneration GO:0031099 32 19 0,000 0,14455789 0,1803054 ! sensory perception of taste GO:0050909 23 19 0,000 0,14455789 0,18020767 ! smooth muscle contraction GO:0006939 36 19 0,000 0,14455789 0,18011005 ! peroxisome organization GO:0007031 29 19 0,000 0,14455789 0,18001254 ! digestive system process GO:0022600 30 19 0,000 0,14455789 0,17991513 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,14455789 0,17981782 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,14455789 0,17972062 ! cytolysis GO:0019835 20 19 0,000 0,14455789 0,17962353 ! renal system process GO:0003014 35 19 0,000 0,14455789 0,17952654 ! vasodilation GO:0042311 33 19 0,000 0,14455789 0,17942966 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,14455789 0,17933288 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,14455789 0,1792362 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,14455789 0,17913963 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,14455789 0,17904316 ! sarcomere organization GO:0045214 23 19 0,000 0,14455789 0,1789468 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,14455789 0,17885054 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,14455789 0,17875438 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,14455789 0,17865833 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,14455789 0,17856238 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,14455789 0,17846653 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,14455789 0,17837079 ! detection of stimulus GO:0051606 108 82 1,000 0,14496158 0,178773 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,14778462 0,18215682 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,14778462 0,18205925 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,15156289 0,18661383 ! iron ion transport GO:0006826 37 20 0,000 0,15156289 0,18651399 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,15156289 0,18641425 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,15156289 0,18631461 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,15156289 0,18621509 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,15156289 0,18611567 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,15156289 0,18601635 ! response to ethanol GO:0045471 37 20 0,000 0,15156289 0,18591714 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,15156289 0,18581804 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,15156289 0,18571904 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,15156289 0,18562015 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,15156289 0,18552136 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,15156289 0,18542268 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,15156289 0,1853241 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,15156289 0,18522563 ! collagen fibril organization GO:0030199 45 20 0,000 0,15156289 0,18512727 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,15156289 0,185029 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,15156289 0,18493084 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,15156289 0,18483279 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,15156289 0,18473484 ! alditol metabolic process GO:0019400 24 20 0,000 0,15156289 0,18463699 ! actin filament-based movement GO:0030048 34 20 0,000 0,15156289 0,18453925 ! rRNA metabolic process GO:0016072 107 85 1,000 0,15346413 0,18675529 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,15346413 0,18665653 ! regulation of membrane potential GO:0042391 128 85 1,000 0,15346413 0,18655788 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,15631988 0,18992906 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,15851092 0,1924895 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,15851092 0,19238792 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,15851092 0,19228645 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,15851092 0,19218509 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,15851092 0,19208383 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,15851092 0,19198268 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,15851092 0,19188164 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,15851092 0,1917807 ! vesicle docking GO:0048278 27 21 0,000 0,15851092 0,19167987 ! phototransduction GO:0007602 25 21 0,000 0,15851092 0,19157914 ! visual behavior GO:0007632 39 21 0,000 0,15851092 0,19147852 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,15851092 0,19137801 ! ovarian follicle development GO:0001541 30 21 0,000 0,15851092 0,1912776 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,15851092 0,1911773 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,15851092 0,1910771 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,15851092 0,19097701 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,15851092 0,19087702 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,15851092 0,19077714 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,15851092 0,19067736 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,15851092 0,19057769 ! fatty acid transport GO:0015908 30 21 0,000 0,15851092 0,19047811 ! immunoglobulin production GO:0002377 33 21 0,000 0,15851092 0,19037865 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,15851092 0,19027929 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,15851092 0,19018003 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,15851092 0,19008087 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,15851092 0,18998182 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,15851092 0,18988287 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,15851092 0,18978402 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,15851092 0,18968528 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,15851092 0,18958664 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,15851092 0,1894881 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,15851092 0,18938967 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,15851092 0,18929134 ! cellular defense response GO:0006968 102 87 1,000 0,1591858 0,18999862 ! female pregnancy GO:0007565 130 87 1,000 0,1591858 0,18990007 ! protein processing GO:0016485 114 88 1,000 0,16206154 0,19323046 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,16494677 0,19656868 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,16540244 0,19700964 ! viral genome replication GO:0019079 29 22 0,000 0,16540244 0,19690767 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,16540244 0,19680581 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,16540244 0,19670404 ! leukocyte adhesion GO:0007159 38 22 0,000 0,16540244 0,19660239 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,16540244 0,19650084 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,16540244 0,19639939 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,16540244 0,19629805 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,16540244 0,19619681 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,16540244 0,19609568 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,16540244 0,19599465 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,16540244 0,19589373 ! lysosome organization GO:0007040 37 22 0,000 0,16540244 0,19579291 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,16540244 0,19569219 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,16540244 0,19559158 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,16540244 0,19549107 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,16540244 0,19539066 ! membrane depolarization GO:0051899 35 22 0,000 0,16540244 0,19529036 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,16540244 0,19519016 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,16540244 0,19509006 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,16540244 0,19499007 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,16540244 0,19489018 ! neural tube closure GO:0001843 33 22 0,000 0,16540244 0,19479038 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,16540244 0,1946907 ! embryonic pattern specification GO:0009880 31 23 0,000 0,17223792 0,20263285 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,17223792 0,20252925 ! vesicle targeting GO:0006903 32 23 0,000 0,17223792 0,20242576 ! osteoblast differentiation GO:0001649 40 23 0,000 0,17223792 0,20232238 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,17223792 0,2022191 ! interaction with host GO:0051701 37 23 0,000 0,17223792 0,20211593 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,17223792 0,20201286 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,17223792 0,2019099 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,17223792 0,20180704 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,17223792 0,20170429 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,17223792 0,20160164 ! cell fate determination GO:0001709 45 23 0,000 0,17223792 0,2014991 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,17223792 0,20139666 ! spermatid development GO:0007286 33 23 0,000 0,17223792 0,20129432 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,17223792 0,20119209 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,17223792 0,20108996 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,17223792 0,20098794 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,17223792 0,20088602 ! telomere organization GO:0032200 32 23 0,000 0,17223792 0,2007842 GO:0000723|telomere maintenance, ! regulation of amine transport GO:0051952 38 23 0,000 0,17223792 0,20068248 ! liver development GO:0001889 40 23 0,000 0,17223792 0,20058087 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,17365586 0,2021298 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,17365586 0,20202756 ! DNA recombination GO:0006310 146 92 1,000 0,17365586 0,20192542 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,1765756 0,20521671 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,1765756 0,20511307 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,17901781 0,207845 ! initiation of viral infection GO:0019059 42 24 0,000 0,17901781 0,20774014 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,17901781 0,20763538 ! superoxide metabolic process GO:0006801 32 24 0,000 0,17901781 0,20753072 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,17901781 0,20742617 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,17901781 0,20732173 ! sperm motility GO:0030317 27 24 0,000 0,17901781 0,20721739 ! vacuole organization GO:0007033 39 24 0,000 0,17901781 0,20711316 ! primary neural tube formation GO:0014020 35 24 0,000 0,17901781 0,20700903 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,17901781 0,206905 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,17901781 0,20680108 ! glutathione metabolic process GO:0006749 29 24 0,000 0,17901781 0,20669727 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,17901781 0,20659355 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,17901781 0,20648995 ! protein maturation GO:0051604 129 96 1,000 0,18538034 0,21372169 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,18574254 0,21403199 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,18574254 0,21392481 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,18574254 0,21381774 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,18574254 0,21371078 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,18574254 0,21360392 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,18574254 0,21349717 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,18574254 0,21339053 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,18574254 0,213284 ! phospholipid transport GO:0015914 35 25 0,000 0,18574254 0,21317757 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,18574254 0,21307125 ! detection of light stimulus GO:0009583 30 25 0,000 0,18574254 0,21296503 ! leukocyte proliferation GO:0070661 39 25 0,000 0,18574254 0,21285892 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,19241258 0,22039289 ! translational initiation GO:0006413 43 26 0,000 0,19241258 0,22028319 ! post-embryonic development GO:0009791 42 26 0,000 0,19241258 0,2201736 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,19241258 0,22006411 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,19241258 0,21995474 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,19241258 0,21984547 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,19241258 0,21973631 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,19241258 0,21962726 ! regulation of coagulation GO:0050818 39 26 0,000 0,19241258 0,21951832 ! extracellular structure organization GO:0043062 156 99 1,000 0,19424683 0,2215011 ! protein import GO:0017038 156 99 1,000 0,19424683 0,22139133 ! regulation of translation GO:0006417 151 100 1,000 0,19721463 0,22466253 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,19721463 0,22455131 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,19721463 0,22444021 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,19721463 0,22432921 ! protein localization in organelle GO:0033365 161 100 1,000 0,19721463 0,22421832 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,19902835 0,22616859 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,19902835 0,2260569 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,19902835 0,22594532 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,19902835 0,22583385 ! membrane docking GO:0022406 39 27 0,000 0,19902835 0,22572249 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,19902835 0,22561125 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,19902835 0,22550011 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,19902835 0,22538908 ! myofibril assembly GO:0030239 36 27 0,000 0,19902835 0,22527816 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,19902835 0,22516735 ! natural killer cell activation GO:0030101 35 27 0,000 0,19902835 0,22505665 ! lipid oxidation GO:0034440 38 27 0,000 0,19902835 0,22494605 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,19902835 0,22483557 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,19902835 0,22472519 ! gene silencing GO:0016458 41 27 0,000 0,19902835 0,22461492 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,20559031 0,23190668 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,20559031 0,231793 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,20559031 0,23167943 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,20559031 0,23156597 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,20559031 0,23145263 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,20559031 0,23133939 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,20559031 0,23122627 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,20559031 0,23111325 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,20559031 0,23100035 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,20559031 0,23088756 ! mesoderm formation GO:0001707 46 28 0,000 0,20559031 0,23077487 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,20559031 0,2306623 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,20559031 0,23054984 ! BMP signaling pathway GO:0030509 40 28 0,000 0,20559031 0,23043748 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,20559031 0,23032524 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,20559031 0,2302131 ! neural tube formation GO:0001841 41 28 0,000 0,20559031 0,23010108 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,21209888 0,23727015 ! regulation of innate immune response GO:0045088 38 29 0,000 0,21209888 0,2371548 ! ovulation cycle process GO:0022602 41 29 0,000 0,21209888 0,23703957 ! protein targeting to membrane GO:0006612 53 29 0,000 0,21209888 0,23692444 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,21209888 0,23680943 ! muscle cell development GO:0055001 38 29 0,000 0,21209888 0,23669453 ! formation of primary germ layer GO:0001704 48 29 0,000 0,21209888 0,23657974 ! eye morphogenesis GO:0048592 51 29 0,000 0,21209888 0,23646506 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,21209888 0,2363505 ! organic anion transport GO:0015711 51 30 0,000 0,2185545 0,24342632 ! cholesterol transport GO:0030301 46 30 0,000 0,2185545 0,24330849 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,2185545 0,24319078 ! spliceosome assembly GO:0000245 49 30 0,000 0,2185545 0,24307318 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,2185545 0,2429557 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,2185545 0,24283833 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,2185545 0,24272107 ! ceramide metabolic process GO:0006672 43 30 0,000 0,2185545 0,24260393 ! ovulation cycle GO:0042698 43 30 0,000 0,2185545 0,2424869 ! hindbrain development GO:0030902 45 30 0,000 0,2185545 0,24236998 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,2185545 0,24225318 ! adult locomotory behavior GO:0008344 47 30 0,000 0,2185545 0,24213649 ! response to heat GO:0009408 41 30 0,000 0,2185545 0,24201991 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,2185545 0,24190344 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,2185545 0,24178708 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,22495759 0,24875118 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,22495759 0,24863164 ! odontogenesis GO:0042476 50 31 0,000 0,22495759 0,24851222 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,22495759 0,24839292 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,22495759 0,24827373 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,22495759 0,24815465 ! RNA modification GO:0009451 40 31 0,000 0,22495759 0,24803569 ! regulation of muscle development GO:0048634 48 32 0,000 0,23130857 0,25491601 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,23130857 0,25479393 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,23130857 0,25467196 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,23130857 0,2545501 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 44 32 0,000 0,23130857 0,25442837 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,23130857 0,25430675 ! vesicle localization GO:0051648 47 32 0,000 0,23130857 0,25418524 ! RNA export from nucleus GO:0006405 44 33 0,000 0,23760788 0,26098286 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,23760788 0,26085829 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,23760788 0,26073384 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,23760788 0,2606095 ! actomyosin structure organization GO:0031032 43 33 0,000 0,23760788 0,26048528 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,23760788 0,26036118 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,23760788 0,2602372 ! positive regulation of cell development GO:0010720 54 33 0,000 0,23760788 0,26011334 ! lipid homeostasis GO:0055088 55 33 0,000 0,23760788 0,25998959 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,23760788 0,25986596 ! mRNA catabolic process GO:0006402 48 34 0,000 0,24385592 0,26657253 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,24385592 0,2664459 ! feeding behavior GO:0007631 45 34 0,000 0,24385592 0,26631938 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,24385592 0,26619298 ! neuron migration GO:0001764 46 34 0,000 0,24385592 0,2660667 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,24385592 0,26594055 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,24385592 0,26581451 ! polyol metabolic process GO:0019751 44 34 0,000 0,24385592 0,26568859 ! aerobic respiration GO:0009060 47 34 0,000 0,24385592 0,26556279 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,24385592 0,26543711 ! embryonic organ development GO:0048568 45 34 0,000 0,24385592 0,26531155 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,24385592 0,26518611 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,25005311 0,27179686 ! Notch signaling pathway GO:0007219 56 35 0,000 0,25005311 0,27166847 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,25005311 0,27154021 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,25005311 0,27141206 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,25005311 0,27128404 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,25005311 0,27115613 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,25005311 0,27102835 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,25005311 0,27090069 ! pigment metabolic process GO:0042440 61 35 0,000 0,25005311 0,27077314 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,25619986 0,27729868 ! organic ether metabolic process GO:0018904 46 36 0,000 0,25619986 0,27716824 ! neural tube development GO:0021915 50 36 0,000 0,25619986 0,27703793 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,25619986 0,27690775 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,25619986 0,27677768 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,26229659 0,28323106 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,26229659 0,28309815 ! ion transmembrane transport GO:0034220 56 37 0,000 0,26229659 0,28296536 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,26229659 0,2828327 ! amino acid activation GO:0043038 52 37 0,000 0,26229659 0,28270016 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,26229659 0,28256775 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,26834368 0,28894685 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,26834368 0,28881164 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,26834368 0,28867655 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,27434155 0,29499092 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,27434155 0,29485307 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,27434155 0,29471535 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,27434155 0,29457776 ! chromatin remodeling GO:0006338 68 39 0,000 0,27434155 0,2944403 ! JNK cascade GO:0007254 54 39 0,000 0,27434155 0,29430297 ! cell growth GO:0016049 61 39 0,000 0,27434155 0,29416577 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,2802906 0,30040465 ! response to calcium ion GO:0051592 58 40 0,000 0,2802906 0,30026473 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,2802906 0,30012494 ! regulation of tube size GO:0035150 60 40 0,000 0,2802906 0,29998528 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,2802906 0,29984575 ! peptide metabolic process GO:0006518 56 40 0,000 0,2802906 0,29970636 ! inner ear development GO:0048839 57 40 0,000 0,2802906 0,29956709 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,2802906 0,29942795 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,2802906 0,29928894 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,2802906 0,29915006 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,28619121 0,30530602 ! striated muscle contraction GO:0006941 62 41 0,000 0,28619121 0,30516448 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,28619121 0,30502307 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,28619121 0,30488179 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,29204378 0,31097254 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,29204378 0,31082864 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,29204378 0,31068487 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,29204378 0,31054123 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,29204378 0,31039773 ! excretion GO:0007588 63 42 0,000 0,29204378 0,31025436 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,29204378 0,31011112 ! tRNA processing GO:0008033 49 43 0,000 0,29784869 0,31612921 ! vesicle organization GO:0016050 79 43 0,000 0,29784869 0,31598339 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,30360634 0,3219431 ! glycolysis GO:0006096 53 44 0,000 0,30360634 0,32179474 ! regulation of ion transport GO:0043269 57 44 0,000 0,30360634 0,32164651 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,30360634 0,32149843 ! RNA catabolic process GO:0006401 64 45 0,000 0,3093171 0,327395 ! regulation of translational initiation GO:0006446 64 45 0,000 0,3093171 0,32724441 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,3093171 0,32709395 ! cell recognition GO:0008037 58 45 0,000 0,3093171 0,32694363 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,31498136 0,33277774 ! cell redox homeostasis GO:0045454 63 46 0,000 0,31498136 0,33262495 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,32059949 0,3384024 ! viral infectious cycle GO:0019058 71 47 0,000 0,32059949 0,33824717 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,32059949 0,33809208 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,32059949 0,33793713 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,32059949 0,33778233 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,32059949 0,33762767 ! chloride transport GO:0006821 67 48 0,000 0,32617186 0,3433388 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,32617186 0,34318174 ! gastrulation GO:0007369 73 48 0,000 0,32617186 0,34302482 ! heart morphogenesis GO:0003007 65 48 0,000 0,32617186 0,34286804 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,32617186 0,34271141 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,32617186 0,34255492 ! regulation of endocytosis GO:0030100 63 48 0,000 0,32617186 0,34239857 ! nuclear export GO:0051168 69 48 0,000 0,32617186 0,34224237 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,33169884 0,34788296 ! sensory perception of smell GO:0007608 61 49 0,000 0,33169884 0,3477244 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,33169884 0,34756598 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,33169884 0,34740771 ! RNA elongation GO:0006354 62 49 0,000 0,33169884 0,34724958 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,33169884 0,3470916 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,33169884 0,34693376 ! regulation of actin filament length GO:0030832 72 50 0,000 0,3371808 0,35250721 ! positive regulation of growth GO:0045927 67 50 0,000 0,3371808 0,35234705 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,3371808 0,35218704 ! proton transport GO:0015992 75 50 0,000 0,3371808 0,35202717 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,3371808 0,35186745 ! hydrogen transport GO:0006818 77 51 0,000 0,34261811 0,35737944 ! adult behavior GO:0030534 80 51 0,000 0,34261811 0,35721743 ! transition metal ion transport GO:0000041 74 52 0,000 0,34801113 0,36267584 ! regulation of cellular component size GO:0032535 74 52 0,000 0,34801113 0,36251159 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,34801113 0,36234748 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,3533602 0,36775044 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,3533602 0,36758411 ! single fertilization GO:0007338 59 53 0,000 0,3533602 0,36741793 ! amino acid transport GO:0006865 84 54 0,000 0,3586657 0,37276598 ! glucose catabolic process GO:0006007 66 54 0,000 0,3586657 0,37259761 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,3586657 0,37242939 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,36392797 0,37772307 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,36392797 0,37755269 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,37432421 0,38816307 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,37432421 0,38798814 ! secondary metabolic process GO:0019748 84 57 0,000 0,37432421 0,38781337 ! viral reproductive process GO:0022415 87 58 0,000 0,37945888 0,39295607 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,37945888 0,39277922 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,38455171 0,39787176 ! activation of MAPK activity GO:0000187 84 59 0,000 0,38455171 0,39769286 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,38455171 0,39751413 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,38960303 0,40255479 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,38960303 0,40237403 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,38960303 0,40219343 ! fertilization GO:0009566 68 60 0,000 0,38960303 0,40201299 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,39461317 0,40700013 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,39461317 0,4068177 ! extracellular matrix organization GO:0030198 103 61 0,000 0,39461317 0,40663544 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,39461317 0,40645334 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,39461317 0,4062714 ! amine catabolic process GO:0009310 90 62 0,000 0,39958248 0,41120345 ! neurotransmitter transport GO:0006836 81 62 0,000 0,39958248 0,41101955 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,39958248 0,41083581 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,39958248 0,41065224 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,39958248 0,41046883 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,4093999 0,42036597 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,4093999 0,42017839 ! hexose catabolic process GO:0019320 82 64 0,000 0,4093999 0,41999098 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,41424867 0,42477572 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,41424867 0,42458643 ! activation of immune response GO:0002253 83 65 0,000 0,41424867 0,4243973 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,4190579 0,4291332 ! antigen processing and presentation GO:0019882 96 66 0,000 0,4190579 0,42894222 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,42382793 0,43363178 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,42855906 0,43827738 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,42855906 0,43808259 ! inorganic anion transport GO:0015698 93 68 0,000 0,42855906 0,43788797 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,4332516 0,4424861 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,4332516 0,4422897 ! response to metal ion GO:0010038 103 70 0,000 0,43790589 0,44684274 ! amine transport GO:0015837 101 70 0,000 0,43790589 0,44664459 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,43790589 0,4464466 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,44252221 0,45095307 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,44252221 0,45075336 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,44252221 0,45055382 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,45164222 0,45963589 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,45614651 0,46401458 ! digestion GO:0007586 97 74 0,000 0,45614651 0,46380945 ! response to inorganic substance GO:0010035 115 75 0,000 0,46061405 0,46814508 ! regulation of ligase activity GO:0051340 114 75 0,000 0,46061405 0,46793831 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,46061405 0,46773171 ! tRNA metabolic process GO:0006399 95 76 0,000 0,46504516 0,47202289 ! response to unfolded protein GO:0006986 99 76 0,000 0,46504516 0,47181467 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,46944011 0,4760636 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,4737992 0,48027244 ! cellular respiration GO:0045333 107 79 0,000 0,47812273 0,48444154 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,47812273 0,48422822 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,47812273 0,48401509 ! chromatin assembly GO:0031497 102 80 0,000 0,48241099 0,48814134 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,48241099 0,48792668 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,48241099 0,48771221 GO:0010498|proteasomal protein catabolic process, ! mRNA transport GO:0051028 121 81 0,000 0,48666425 0,49179603 ! response to protein stimulus GO:0051789 111 81 0,000 0,48666425 0,49158005 ! vitamin metabolic process GO:0006766 103 81 0,000 0,48666425 0,49136425 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,4992169 0,50381697 ! sterol metabolic process GO:0016125 120 84 0,000 0,4992169 0,50359599 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,503333 0,50752561 ! nucleosome organization GO:0034728 114 87 0,000 0,51146469 0,51549903 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,51146469 0,51527323 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,51548082 0,51909189 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,51548082 0,51886472 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,51548082 0,51863775 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,51946416 0,52241695 ! hormone metabolic process GO:0042445 121 90 0,000 0,52341498 0,52616017 ! RNA localization GO:0006403 135 91 0,000 0,52733355 0,5298677 ! ATP metabolic process GO:0046034 137 91 0,000 0,52733355 0,52963631 ! positive regulation of immune response GO:0050778 121 92 0,000 0,53122011 0,53330697 ! sulfur metabolic process GO:0006790 118 92 0,000 0,53122011 0,53307429 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,53507495 0,53670841 ! electron transport chain GO:0022900 123 94 0,000 0,5388983 0,5403078 ! carboxylic acid transport GO:0046942 147 95 0,000 0,54269043 0,54387276 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,54645159 0,54740359 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,55018203 0,55090059 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,55755174 0,55803699 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,56119151 0,56143561 ! divalent metal ion transport GO:0070838 171 100 0,000 0,56119151 0,56119151