pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6935-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of transferase activity GO:0051347 91 88 7,000 7,723E-07 1,423E-03 GO:0033674|positive regulation of kinase activity, ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 3,000 1,648E-06 1,519E-03 GO:0032388|positive regulation of intracellular transport, ! regulation of intracellular protein transport GO:0033157 25 25 4,000 1,979E-06 1,216E-03 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 4,000 2,967E-06 1,367E-03 ! positive regulation of protein transport GO:0051222 29 29 4,000 4,307E-06 1,588E-03 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 3,000 4,902E-06 1,506E-03 ! response to molecule of bacterial origin GO:0002237 14 14 3,000 4,902E-06 1,291E-03 ! regulation of protein transport GO:0051223 53 53 5,000 5,693E-06 1,312E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of intracellular transport GO:0032386 31 31 4,000 6,081E-06 1,245E-03 ! positive regulation of protein kinase activity GO:0045860 89 86 6,000 8,419E-06 1,552E-03 ! regulation of protein localization GO:0032880 58 57 5,000 8,759E-06 1,468E-03 ! regulation of angiogenesis GO:0045765 35 34 4,000 9,76E-06 1,499E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 2,000 1,238E-05 1,755E-03 ! ER overload response GO:0006983 6 6 2,000 1,238E-05 1,63E-03 ! regulation of cell migration GO:0030334 71 71 5,000 3,145E-05 3,865E-03 ! positive regulation of leukocyte migration GO:0002687 8 8 2,000 3,424E-05 3,944E-03 ! positive regulation of protein import into nucleus GO:0042307 9 9 2,000 5,104E-05 5,533E-03 ! regulation of leukocyte migration GO:0002685 9 9 2,000 5,104E-05 5,226E-03 ! regulation of locomotion GO:0040012 79 79 5,000 5,784E-05 5,61E-03 ! regulation of cell motion GO:0051270 79 79 5,000 5,784E-05 5,33E-03 ! regulation of cellular localization GO:0060341 86 85 5,000 8,74E-05 7,67E-03 ! protein amino acid autophosphorylation GO:0046777 28 28 3,000 9,153E-05 7,667E-03 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 5,000 9,332E-05 7,478E-03 ! regulation of epithelial cell proliferation GO:0050678 29 29 3,000 1,055E-04 8,1E-03 ! response to UV GO:0009411 29 29 3,000 1,055E-04 7,776E-03 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 2,000 1,695E-04 0,01201514 ! vasculogenesis GO:0001570 13 13 2,000 1,695E-04 0,01157013 ! negative regulation of protein catabolic process GO:0042177 13 13 2,000 1,695E-04 0,01115691 ! response to endoplasmic reticulum stress GO:0034976 13 13 2,000 1,695E-04 0,01077219 ! positive regulation of locomotion GO:0040017 13 13 2,000 1,695E-04 0,01041312 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! activation of protein kinase activity GO:0032147 35 33 3,000 1,771E-04 0,01052652 ! regulation of protein catabolic process GO:0042176 35 34 3,000 1,994E-04 0,01148229 ! response to retinoic acid GO:0032526 14 14 2,000 2,144E-04 0,01197357 GO:0033189|response to vitamin A, ! regulation of behavior GO:0050795 14 14 2,000 2,144E-04 0,01162141 ! base-excision repair GO:0006284 14 14 2,000 2,144E-04 0,01128937 ! DNA modification GO:0006304 14 14 2,000 2,144E-04 0,01097577 ! positive regulation of cell migration GO:0030335 36 36 3,000 2,5E-04 0,01245047 ! response to vitamin GO:0033273 15 15 2,000 2,663E-04 0,0129171 ! regulation of transcription factor import into nucleus GO:0042990 15 15 2,000 2,663E-04 0,01258589 ! ER-nuclear signaling pathway GO:0006984 15 15 2,000 2,663E-04 0,01227124 ! regulation of transcription factor activity GO:0051090 38 37 3,000 2,784E-04 0,01251605 GO:0090046|regulation of transcription regulator activity, ! response to radiation GO:0009314 70 68 4,000 2,915E-04 0,01279114 ! chromosome segregation GO:0007059 38 38 3,000 3,092E-04 0,01325145 ! response to nutrient levels GO:0031667 69 69 4,000 3,122E-04 0,01307628 ! positive regulation of transport GO:0051050 71 70 4,000 3,34E-04 0,01367788 ! cytokine-mediated signaling pathway GO:0019221 39 39 3,000 3,423E-04 0,01371347 ! developmental maturation GO:0021700 39 39 3,000 3,423E-04 0,01342169 ! protein oligomerization GO:0051259 39 39 3,000 3,423E-04 0,01314208 ! positive regulation of cell motion GO:0051272 39 39 3,000 3,423E-04 0,01287387 ! response to extracellular stimulus GO:0009991 72 72 4,000 3,81E-04 0,0140428 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 2,000 3,931E-04 0,01420628 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 2,000 4,688E-04 0,01661621 ! negative regulation of catabolic process GO:0009895 18 18 2,000 4,688E-04 0,01630269 ! regulation of DNA binding GO:0051101 47 45 3,000 5,963E-04 0,02035226 ! establishment or maintenance of cell polarity GO:0007163 21 20 2,000 6,469E-04 0,02167688 ! regulation of catabolic process GO:0009894 48 47 3,000 7,047E-04 0,02319087 ! neuron fate specification GO:0048665 5 5 1,000 7,354E-04 0,02377931 ! filopodium assembly GO:0046847 7 5 1,000 7,354E-04 0,02336932 GO:0030035|microspike assembly, ! mRNA stabilization GO:0048255 5 5 1,000 7,354E-04 0,02297323 GO:0043489|RNA stabilization, ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 7,354E-04 0,02259034 ! erythrocyte maturation GO:0043249 5 5 1,000 7,354E-04 0,02222001 ! amyloid precursor protein catabolic process GO:0042987 5 5 1,000 7,354E-04 0,02186162 ! endocrine pancreas development GO:0031018 5 5 1,000 7,354E-04 0,02151461 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 1,000 7,354E-04 0,02117845 GO:0033135|regulation of peptidyl-serine phosphorylation, ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 7,354E-04 0,02085262 ! receptor clustering GO:0043113 5 5 1,000 7,354E-04 0,02053667 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 7,354E-04 0,02023016 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 1,000 7,354E-04 0,01993265 ! decidualization GO:0046697 5 5 1,000 7,354E-04 0,01964378 ! hair follicle maturation GO:0048820 5 5 1,000 7,354E-04 0,01936315 ! positive regulation of interleukin-6 production GO:0032755 5 5 1,000 7,354E-04 0,01909043 ! postreplication repair GO:0006301 5 5 1,000 7,354E-04 0,01882528 ! spinal cord motor neuron differentiation GO:0021522 5 5 1,000 7,354E-04 0,0185674 GO:0021517|ventral spinal cord development, ! DNA methylation GO:0006306 5 5 1,000 7,354E-04 0,01831649 GO:0006305|DNA alkylation, ! T cell lineage commitment GO:0002360 5 5 1,000 7,354E-04 0,01807227 ! peptidyl-lysine modification GO:0018205 5 5 1,000 7,354E-04 0,01783448 ! negative regulation of neuroblast proliferation GO:0007406 5 5 1,000 7,354E-04 0,01760286 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 1,000 7,354E-04 0,01737719 GO:0002688|regulation of leukocyte chemotaxis, ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 1,000 7,354E-04 0,01715722 ! positive regulation of T-helper cell differentiation GO:0045624 5 5 1,000 7,354E-04 0,01694276 GO:0045622|regulation of T-helper cell differentiation, ! positive regulation of viral reproduction GO:0048524 5 5 1,000 7,354E-04 0,01673359 ! myeloid cell homeostasis GO:0002262 5 5 1,000 7,354E-04 0,01652952 ! blastocyst formation GO:0001825 5 5 1,000 7,354E-04 0,01633037 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 7,354E-04 0,01613596 ! nucleus localization GO:0051647 5 5 1,000 7,354E-04 0,01594612 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 2,000 7,5E-04 0,01607362 ! regulation of protein import into nucleus GO:0042306 21 21 2,000 7,5E-04 0,01588887 ! negative regulation of protein transport GO:0051224 21 21 2,000 7,5E-04 0,01570831 ! actin filament organization GO:0007015 50 48 3,000 7,637E-04 0,01581557 ! cell cycle arrest GO:0007050 49 49 3,000 8,263E-04 0,01691989 ! response to nutrient GO:0007584 49 49 3,000 8,263E-04 0,01673396 ! response to bacterium GO:0009617 50 49 3,000 8,263E-04 0,01655207 ! positive regulation of MAP kinase activity GO:0043406 50 49 3,000 8,263E-04 0,01637409 ! positive regulation of transcription factor activity GO:0051091 22 22 2,000 8,631E-04 0,01692234 GO:0090047|positive regulation of transcription regulator activity, ! cell junction organization GO:0034330 23 22 2,000 8,631E-04 0,01674421 ! negative regulation of transport GO:0051051 51 50 3,000 8,923E-04 0,01713023 ! calcium-mediated signaling GO:0019722 23 23 2,000 9,864E-04 0,01874226 ! cell projection assembly GO:0030031 25 23 2,000 9,864E-04 0,01855102 ! response to light stimulus GO:0009416 53 52 3,000 1,035E-03 0,01927522 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 1,097E-03 0,02021721 GO:0018409|peptide or protein amino-terminal blocking, ! regulation of lipid kinase activity GO:0043550 6 6 1,000 1,097E-03 0,02001704 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 1,097E-03 0,0198208 GO:0050927|positive regulation of positive chemotaxis, ! regulation of chemokine biosynthetic process GO:0045073 6 6 1,000 1,097E-03 0,01962836 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 1,000 1,097E-03 0,01943963 ! oligodendrocyte differentiation GO:0048709 6 6 1,000 1,097E-03 0,01925449 ! L-serine metabolic process GO:0006563 6 6 1,000 1,097E-03 0,01907284 ! focal adhesion formation GO:0048041 7 6 1,000 1,097E-03 0,01889459 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 1,097E-03 0,01871964 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 1,097E-03 0,0185479 ! peptidyl-serine phosphorylation GO:0018105 6 6 1,000 1,097E-03 0,01837929 ! regulation of bone resorption GO:0045124 6 6 1,000 1,097E-03 0,01821371 ! G1 DNA damage checkpoint GO:0031571 6 6 1,000 1,097E-03 0,01805108 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 1,097E-03 0,01789134 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 1,097E-03 0,0177344 ! erythrocyte development GO:0048821 6 6 1,000 1,097E-03 0,01758019 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 1,000 1,097E-03 0,01742863 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! nitric oxide metabolic process GO:0046209 6 6 1,000 1,097E-03 0,01727967 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 1,000 1,097E-03 0,01713323 ! regulation of T-helper 2 type immune response GO:0002828 6 6 1,000 1,097E-03 0,01698926 ! salivary gland morphogenesis GO:0007435 6 6 1,000 1,097E-03 0,01684768 ! serine family amino acid biosynthetic process GO:0009070 6 6 1,000 1,097E-03 0,01670844 ! maternal placenta development GO:0001893 6 6 1,000 1,097E-03 0,01657149 ! localization within membrane GO:0051668 6 6 1,000 1,097E-03 0,01643676 ! regulation of T cell proliferation GO:0042129 25 25 2,000 1,265E-03 0,01880613 ! positive regulation of DNA binding GO:0043388 26 25 2,000 1,265E-03 0,01865568 ! positive regulation of binding GO:0051099 27 26 2,000 1,422E-03 0,02079248 ! regulation of T cell differentiation GO:0045580 26 26 2,000 1,422E-03 0,02062876 ! regulation of binding GO:0051098 60 57 3,000 1,463E-03 0,02105852 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 1,000 1,527E-03 0,02181811 ! regulation of chemokine production GO:0032642 7 7 1,000 1,527E-03 0,02165028 ! negative regulation of muscle cell differentiation GO:0051148 7 7 1,000 1,527E-03 0,02148501 ! amyloid precursor protein metabolic process GO:0042982 7 7 1,000 1,527E-03 0,02132224 ! cell differentiation in spinal cord GO:0021515 7 7 1,000 1,527E-03 0,02116193 ! regulation of mRNA processing GO:0050684 7 7 1,000 1,527E-03 0,021004 ! membrane protein ectodomain proteolysis GO:0006509 7 7 1,000 1,527E-03 0,02084842 GO:0033619|membrane protein proteolysis, ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 1,527E-03 0,02069512 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! response to X-ray GO:0010165 7 7 1,000 1,527E-03 0,02054406 ! regulation of intracellular pH GO:0051453 7 7 1,000 1,527E-03 0,02039519 ! platelet activation GO:0030168 8 7 1,000 1,527E-03 0,02024846 ! response to gamma radiation GO:0010332 8 7 1,000 1,527E-03 0,02010383 ! synaptic transmission, cholinergic GO:0007271 7 7 1,000 1,527E-03 0,01996125 ! positive regulation of acute inflammatory response GO:0002675 7 7 1,000 1,527E-03 0,01982068 ! regulation of mRNA stability GO:0043488 7 7 1,000 1,527E-03 0,01968207 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 1,000 1,527E-03 0,01954539 ! negative regulation of T cell activation GO:0050868 7 7 1,000 1,527E-03 0,01941059 ! response to cold GO:0009409 7 7 1,000 1,527E-03 0,01927765 ! peptidyl-amino acid modification GO:0018193 61 59 3,000 1,663E-03 0,02085532 ! hemopoiesis GO:0030097 104 100 4,000 1,702E-03 0,02119428 ! regulation of mast cell proliferation GO:0070666 28 28 2,000 1,769E-03 0,02188187 ! positive regulation of cell cycle GO:0045787 29 29 2,000 1,961E-03 0,02409445 ! regulation of lymphocyte proliferation GO:0050670 29 29 2,000 1,961E-03 0,02393488 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! very-long-chain fatty acid metabolic process GO:0000038 8 8 1,000 2,025E-03 0,02455054 ! positive regulation of translation GO:0045727 8 8 1,000 2,025E-03 0,02439007 ! negative regulation of bone remodeling GO:0046851 8 8 1,000 2,025E-03 0,0242317 ! pancreas development GO:0031016 8 8 1,000 2,025E-03 0,02407536 ! negative regulation of proteolysis GO:0045861 8 8 1,000 2,025E-03 0,02392103 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 1,000 2,025E-03 0,02376867 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 2,025E-03 0,02361824 ! sex determination GO:0007530 8 8 1,000 2,025E-03 0,02346969 ! plasma membrane fusion GO:0045026 8 8 1,000 2,025E-03 0,02332301 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 1,000 2,025E-03 0,02317815 ! base-excision repair, AP site formation GO:0006285 8 8 1,000 2,025E-03 0,02303507 ! salivary gland development GO:0007431 8 8 1,000 2,025E-03 0,02289375 ! peptidyl-serine modification GO:0018209 8 8 1,000 2,025E-03 0,02275415 ! regulation of acute inflammatory response GO:0002673 8 8 1,000 2,025E-03 0,02261625 ! regulation of immunoglobulin production GO:0002637 8 8 1,000 2,025E-03 0,02248001 ! regulation of RNA stability GO:0043487 8 8 1,000 2,025E-03 0,0223454 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 2,025E-03 0,02221239 ! peptide hormone secretion GO:0030072 8 8 1,000 2,025E-03 0,02208095 ! cytoplasmic sequestering of protein GO:0051220 8 8 1,000 2,025E-03 0,02195107 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 2,165E-03 0,02333907 ! regulation of inflammatory response GO:0050727 30 30 2,000 2,165E-03 0,02320337 ! establishment of organelle localization GO:0051656 31 30 2,000 2,165E-03 0,02306925 ! regulation of response to external stimulus GO:0032101 65 64 3,000 2,248E-03 0,02381364 ! membrane fusion GO:0006944 31 31 2,000 2,383E-03 0,02509342 ! regulation of MAP kinase activity GO:0043405 67 66 3,000 2,517E-03 0,026362 ! positive regulation of cell projection organization GO:0031346 9 9 1,000 2,589E-03 0,02695481 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 1,000 2,589E-03 0,02680337 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 2,589E-03 0,02665363 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 2,589E-03 0,02650556 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 1,000 2,589E-03 0,02635912 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 1,000 2,589E-03 0,02621429 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 1,000 2,589E-03 0,02607104 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 1,000 2,589E-03 0,02592935 ! pigmentation during development GO:0048066 9 9 1,000 2,589E-03 0,02578919 ! peptide secretion GO:0002790 9 9 1,000 2,589E-03 0,02565054 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 1,000 2,589E-03 0,02551337 ! prostaglandin metabolic process GO:0006693 9 9 1,000 2,589E-03 0,02537766 GO:0006692|prostanoid metabolic process, ! regulation of cellular pH GO:0030641 9 9 1,000 2,589E-03 0,02524339 ! histone acetylation GO:0016573 9 9 1,000 2,589E-03 0,02511053 ! negative regulation of tissue remodeling GO:0034104 9 9 1,000 2,589E-03 0,02497906 ! collagen catabolic process GO:0030574 9 9 1,000 2,589E-03 0,02484896 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 2,589E-03 0,02472021 ! defense response to virus GO:0051607 9 9 1,000 2,589E-03 0,02459279 ! negative regulation of cell growth GO:0030308 32 32 2,000 2,613E-03 0,02469624 ! cell maturation GO:0048469 32 32 2,000 2,613E-03 0,02457024 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 2,000 2,613E-03 0,02444552 ! regulation of lymphocyte differentiation GO:0045619 32 32 2,000 2,613E-03 0,02432205 ! negative regulation of cell size GO:0045792 33 33 2,000 2,857E-03 0,02645583 ! regulation of bone remodeling GO:0046850 34 34 2,000 3,114E-03 0,02869321 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 3,218E-03 0,0295043 ! neuron maturation GO:0042551 10 10 1,000 3,218E-03 0,02935824 ! positive regulation of anti-apoptosis GO:0045768 10 10 1,000 3,218E-03 0,02921362 GO:0045767|regulation of anti-apoptosis, ! hormone secretion GO:0046879 10 10 1,000 3,218E-03 0,02907042 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 1,000 3,218E-03 0,02892861 ! calcium-independent cell-cell adhesion GO:0016338 10 10 1,000 3,218E-03 0,02878818 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 3,218E-03 0,02864911 ! cell-substrate junction assembly GO:0007044 11 10 1,000 3,218E-03 0,02851137 ! exocrine system development GO:0035272 10 10 1,000 3,218E-03 0,02837495 ! neuromuscular junction development GO:0007528 10 10 1,000 3,218E-03 0,02823983 ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 1,000 3,218E-03 0,028106 ! mismatch repair GO:0006298 10 10 1,000 3,218E-03 0,02797342 ! gland morphogenesis GO:0022612 10 10 1,000 3,218E-03 0,02784209 ! epithelial to mesenchymal transition GO:0001837 10 10 1,000 3,218E-03 0,02771199 ! positive regulation of neuron apoptosis GO:0043525 10 10 1,000 3,218E-03 0,02758309 ! negative regulation of homeostatic process GO:0032845 10 10 1,000 3,218E-03 0,02745539 ! protein stabilization GO:0050821 10 10 1,000 3,218E-03 0,02732887 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 2,000 3,385E-03 0,02861468 ! mesoderm development GO:0007498 35 35 2,000 3,385E-03 0,02848401 ! positive regulation of phosphorylation GO:0042327 35 35 2,000 3,385E-03 0,02835454 ! regulation of tissue remodeling GO:0034103 35 35 2,000 3,385E-03 0,02822624 ! response to steroid hormone stimulus GO:0048545 35 35 2,000 3,385E-03 0,0280991 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 2,000 3,67E-03 0,0303283 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 1,000 3,911E-03 0,03217711 ! myeloid leukocyte differentiation GO:0002573 12 11 1,000 3,911E-03 0,0320341 ! signal complex assembly GO:0007172 11 11 1,000 3,911E-03 0,03189235 ! protein amino acid acetylation GO:0006473 11 11 1,000 3,911E-03 0,03175186 ! regulation of viral genome replication GO:0045069 11 11 1,000 3,911E-03 0,0316126 ! spinal cord development GO:0021510 11 11 1,000 3,911E-03 0,03147455 ! activation of MAPKK activity GO:0000186 12 11 1,000 3,911E-03 0,0313377 ! cellular response to starvation GO:0009267 11 11 1,000 3,911E-03 0,03120204 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 1,000 3,911E-03 0,03106755 ! apoptotic nuclear changes GO:0030262 11 11 1,000 3,911E-03 0,03093421 ! response to lipopolysaccharide GO:0032496 11 11 1,000 3,911E-03 0,03080202 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 1,000 3,911E-03 0,03067095 ! G1/S transition checkpoint GO:0031575 12 11 1,000 3,911E-03 0,03054098 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 1,000 3,911E-03 0,03041212 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 3,911E-03 0,03028434 ! negative regulation of angiogenesis GO:0016525 11 11 1,000 3,911E-03 0,03015762 ! proximal/distal pattern formation GO:0009954 11 11 1,000 3,911E-03 0,03003197 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 3,911E-03 0,02990735 ! negative regulation of protein kinase activity GO:0006469 37 37 2,000 3,969E-03 0,03022598 ! response to drug GO:0042493 37 37 2,000 3,969E-03 0,03010159 ! lung development GO:0030324 38 37 2,000 3,969E-03 0,02997822 ! negative regulation of growth GO:0045926 37 37 2,000 3,969E-03 0,02985586 ! response to oxidative stress GO:0006979 76 75 3,000 4,006E-03 0,03000986 ! negative regulation of kinase activity GO:0033673 38 38 2,000 4,283E-03 0,03195473 ! cell-matrix adhesion GO:0007160 39 38 2,000 4,283E-03 0,03182588 ! cell morphogenesis involved in differentiation GO:0000904 82 77 3,000 4,403E-03 0,03258673 ! positive regulation of protein kinase cascade GO:0010740 79 78 3,000 4,611E-03 0,03399068 ! respiratory tube development GO:0030323 40 39 2,000 4,611E-03 0,03385651 ! respiratory system development GO:0060541 40 39 2,000 4,611E-03 0,03372216 ! positive regulation of protein catabolic process GO:0045732 12 12 1,000 4,667E-03 0,03399544 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 1,000 4,667E-03 0,0338616 ! collagen metabolic process GO:0032963 12 12 1,000 4,667E-03 0,03372881 ! xenobiotic metabolic process GO:0006805 12 12 1,000 4,667E-03 0,03359706 ! regulation of muscle cell differentiation GO:0051147 13 12 1,000 4,667E-03 0,03346633 ! glycoprotein catabolic process GO:0006516 13 12 1,000 4,667E-03 0,03333661 ! acute-phase response GO:0006953 12 12 1,000 4,667E-03 0,0332079 ! deoxyribonucleotide catabolic process GO:0009264 12 12 1,000 4,667E-03 0,03308018 ! regulation of alpha-beta T cell activation GO:0046634 12 12 1,000 4,667E-03 0,03295343 ! regulation of interleukin-6 production GO:0032675 12 12 1,000 4,667E-03 0,03282766 ! regulation of chromosome organization GO:0033044 12 12 1,000 4,667E-03 0,03270284 ! somitogenesis GO:0001756 13 12 1,000 4,667E-03 0,03257896 ! hormone transport GO:0009914 12 12 1,000 4,667E-03 0,03245602 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 4,667E-03 0,03233401 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 1,000 4,667E-03 0,03221291 ! negative regulation of transferase activity GO:0051348 40 40 2,000 4,954E-03 0,03406921 ! myeloid cell differentiation GO:0030099 42 40 2,000 4,954E-03 0,03394256 ! organelle localization GO:0051640 41 40 2,000 4,954E-03 0,03381685 ! neuron projection development GO:0031175 85 80 3,000 5,047E-03 0,03432165 ! regulation of caspase activity GO:0043281 41 41 2,000 5,312E-03 0,03599579 ! negative regulation of hormone secretion GO:0046888 13 13 1,000 5,484E-03 0,03702505 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 1,000 5,484E-03 0,03688992 GO:0019692|deoxyribose phosphate metabolic process, ! positive regulation of JAK-STAT cascade GO:0046427 13 13 1,000 5,484E-03 0,03675577 ! mitochondrial membrane organization GO:0007006 13 13 1,000 5,484E-03 0,0366226 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 1,000 5,484E-03 0,03649039 ! negative regulation of DNA replication GO:0008156 13 13 1,000 5,484E-03 0,03635913 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 1,000 5,484E-03 0,03622881 ! response to corticosteroid stimulus GO:0031960 13 13 1,000 5,484E-03 0,03609942 GO:0051384|response to glucocorticoid stimulus, ! multicellular organismal catabolic process GO:0044243 13 13 1,000 5,484E-03 0,03597095 ! receptor metabolic process GO:0043112 14 13 1,000 5,484E-03 0,0358434 ! actin filament bundle formation GO:0051017 13 13 1,000 5,484E-03 0,03571674 ! cell aging GO:0007569 13 13 1,000 5,484E-03 0,03559098 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 1,000 5,484E-03 0,0354661 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 5,484E-03 0,03534209 ! regulation of viral reproduction GO:0050792 13 13 1,000 5,484E-03 0,03521895 ! negative regulation of phosphorylation GO:0042326 13 13 1,000 5,484E-03 0,03509666 ! negative regulation of intracellular transport GO:0032387 13 13 1,000 5,484E-03 0,03497522 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 5,484E-03 0,03485461 ! cell-cell junction organization GO:0045216 13 13 1,000 5,484E-03 0,03473484 ! blastocyst development GO:0001824 13 13 1,000 5,484E-03 0,03461588 ! tissue homeostasis GO:0001894 13 13 1,000 5,484E-03 0,03449774 GO:0048871|multicellular organismal homeostasis, ! protein tetramerization GO:0051262 13 13 1,000 5,484E-03 0,0343804 ! regulation of endopeptidase activity GO:0052548 42 42 2,000 5,686E-03 0,03552285 ! cell-substrate adhesion GO:0031589 43 42 2,000 5,686E-03 0,03540284 ! blood vessel morphogenesis GO:0048514 84 83 3,000 5,751E-03 0,03568968 ! homeostasis of number of cells GO:0048872 44 43 2,000 6,075E-03 0,03757053 ! neuron fate commitment GO:0048663 14 14 1,000 6,363E-03 0,03921947 ! protein amino acid acylation GO:0043543 14 14 1,000 6,363E-03 0,03908874 ! hair cycle GO:0042633 14 14 1,000 6,363E-03 0,03895888 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! D-ribose metabolic process GO:0006014 14 14 1,000 6,363E-03 0,03882988 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 1,000 6,363E-03 0,03870172 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 1,000 6,363E-03 0,03857442 ! positive regulation of inflammatory response GO:0050729 14 14 1,000 6,363E-03 0,03844794 ! positive regulation of osteoblast differentiation GO:0045669 14 14 1,000 6,363E-03 0,0383223 ! phosphoinositide-mediated signaling GO:0048015 45 45 2,000 6,9E-03 0,04142005 ! Wnt receptor signaling pathway GO:0016055 46 45 2,000 6,9E-03 0,04128557 ! protein import into nucleus, translocation GO:0000060 15 15 1,000 7,301E-03 0,04354435 ! negative regulation of protein complex assembly GO:0031333 15 15 1,000 7,301E-03 0,04340388 ! insulin receptor signaling pathway GO:0008286 17 15 1,000 7,301E-03 0,04326432 ! deoxyribonucleotide metabolic process GO:0009262 15 15 1,000 7,301E-03 0,04312565 ! chromosome condensation GO:0030261 15 15 1,000 7,301E-03 0,04298787 ! response to starvation GO:0042594 15 15 1,000 7,301E-03 0,04285096 ! response to ionizing radiation GO:0010212 16 15 1,000 7,301E-03 0,04271493 ! response to mechanical stimulus GO:0009612 15 15 1,000 7,301E-03 0,04257976 ! regulation of production of molecular mediator of immune response GO:0002700 15 15 1,000 7,301E-03 0,04244543 ! leukocyte homeostasis GO:0001776 15 15 1,000 7,301E-03 0,04231196 ! positive regulation of B cell activation GO:0050871 15 15 1,000 7,301E-03 0,04217932 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 7,301E-03 0,04204751 GO:0090048|negative regulation of transcription regulator activity, ! negative regulation of cell activation GO:0050866 15 15 1,000 7,301E-03 0,04191652 ! protein homooligomerization GO:0051260 15 15 1,000 7,301E-03 0,04178634 ! regulation of peptidase activity GO:0052547 46 46 2,000 7,336E-03 0,04185659 ! negative regulation of cell cycle GO:0045786 92 91 3,000 7,945E-03 0,04519192 ! DNA replication GO:0006260 91 91 3,000 7,945E-03 0,04505287 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 1,000 8,297E-03 0,04690677 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 8,297E-03 0,04676332 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of synaptic plasticity GO:0048167 16 16 1,000 8,297E-03 0,04662075 ! positive regulation of mitosis GO:0045840 16 16 1,000 8,297E-03 0,04647905 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 1,000 8,297E-03 0,0463382 ! cellular response to reactive oxygen species GO:0034614 16 16 1,000 8,297E-03 0,04619821 ! segmentation GO:0035282 17 16 1,000 8,297E-03 0,04605905 ! cell fate specification GO:0001708 16 16 1,000 8,297E-03 0,04592074 ! pentose metabolic process GO:0019321 16 16 1,000 8,297E-03 0,04578325 ! positive regulation of MAPKKK cascade GO:0043410 17 16 1,000 8,297E-03 0,04564659 ! cellular response to nutrient levels GO:0031669 16 16 1,000 8,297E-03 0,04551073 ! serine family amino acid metabolic process GO:0009069 16 16 1,000 8,297E-03 0,04537569 ! positive regulation of catabolic process GO:0009896 16 16 1,000 8,297E-03 0,04524144 ! response to xenobiotic stimulus GO:0009410 16 16 1,000 8,297E-03 0,04510798 ! leukocyte differentiation GO:0002521 50 49 2,000 8,741E-03 0,04737937 ! gland development GO:0048732 51 49 2,000 8,741E-03 0,04724042 ! skeletal muscle tissue development GO:0007519 50 49 2,000 8,741E-03 0,04710229 GO:0060538|skeletal muscle organ development, ! blood vessel development GO:0001568 95 94 3,000 8,892E-03 0,04777612 ! regulation of defense response GO:0031347 50 50 2,000 9,242E-03 0,04951235 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 2,000 9,242E-03 0,04936884 ! regulation of neurogenesis GO:0050767 51 50 2,000 9,242E-03 0,04922615 ! anatomical structure homeostasis GO:0060249 51 50 2,000 9,242E-03 0,04908429 ! anterior/posterior pattern formation GO:0009952 51 50 2,000 9,242E-03 0,04894325 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 1,000 9,351E-03 0,04938076 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 9,351E-03 0,04923967 ! myelination GO:0042552 17 17 1,000 9,351E-03 0,04909938 ! negative regulation of cell development GO:0010721 18 17 1,000 9,351E-03 0,0489599 GO:0050768|negative regulation of neurogenesis, ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 9,351E-03 0,0488212 ! positive regulation of protein secretion GO:0050714 17 17 1,000 9,351E-03 0,04868329 ! regulation of fibroblast proliferation GO:0048145 17 17 1,000 9,351E-03 0,04854615 ! glucose transport GO:0015758 17 17 1,000 9,351E-03 0,04840979 ! cell junction assembly GO:0034329 18 17 1,000 9,351E-03 0,04827419 ! tissue remodeling GO:0048771 17 17 1,000 9,351E-03 0,04813934 ! response to toxin GO:0009636 18 17 1,000 9,351E-03 0,04800525 ! regulation of osteoblast differentiation GO:0045667 17 17 1,000 9,351E-03 0,0478719 ! pigmentation GO:0043473 17 17 1,000 9,351E-03 0,04773929 ! vasculature development GO:0001944 97 96 3,000 9,562E-03 0,04868279 ! protein modification by small protein conjugation GO:0032446 52 51 2,000 9,759E-03 0,04954809 ! rRNA metabolic process GO:0016072 51 51 2,000 9,759E-03 0,04941197 GO:0006364|rRNA processing, ! interphase of mitotic cell cycle GO:0051329 52 51 2,000 9,759E-03 0,0492766 GO:0051325|interphase, ! posttranscriptional regulation of gene expression GO:0010608 98 98 3,000 0,01026506 0,05168989 ! blood circulation GO:0008015 99 98 3,000 0,01026506 0,05154905 GO:0003013|circulatory system process, ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 2,000 0,01029317 0,05154975 ! cell fate commitment GO:0045165 52 52 2,000 0,01029317 0,05141005 ! regulation of cell projection organization GO:0031344 19 18 1,000 0,01046127 0,05210842 ! icosanoid biosynthetic process GO:0046456 18 18 1,000 0,01046127 0,05196796 ! meiosis I GO:0007127 18 18 1,000 0,01046127 0,05182826 ! hexose transport GO:0008645 18 18 1,000 0,01046127 0,05168931 GO:0015749|monosaccharide transport, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 0,01046127 0,05155111 ! negative regulation of DNA binding GO:0043392 19 18 1,000 0,01046127 0,05141364 ! B cell differentiation GO:0030183 18 18 1,000 0,01046127 0,0512769 ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 0,01046127 0,05114089 ! ensheathment of neurons GO:0007272 18 18 1,000 0,01046127 0,05100559 GO:0008366|axon ensheathment, ! response to hypoxia GO:0001666 53 53 2,000 0,010844 0,05273215 ! regulation of T cell activation GO:0050863 53 53 2,000 0,010844 0,05259338 ! response to hormone stimulus GO:0009725 102 100 3,000 0,01100069 0,05321329 ! response to other organism GO:0051707 101 100 3,000 0,01100069 0,05307399 ! response to oxygen levels GO:0070482 55 54 2,000 0,01141165 0,05491296 ! negative regulation of multicellular organismal process GO:0051241 55 54 2,000 0,01141165 0,05476996 ! DNA damage checkpoint GO:0000077 19 19 1,000 0,01162691 0,05565818 ! negative regulation of DNA metabolic process GO:0051053 19 19 1,000 0,01162691 0,05551398 ! glial cell differentiation GO:0010001 19 19 1,000 0,01162691 0,05537054 ! regulation of pH GO:0006885 19 19 1,000 0,01162691 0,05522783 ! regulation of JAK-STAT cascade GO:0046425 19 19 1,000 0,01162691 0,05508586 ! regulation of endothelial cell proliferation GO:0001936 19 19 1,000 0,01162691 0,05494461 ! positive regulation of T cell proliferation GO:0042102 19 19 1,000 0,01162691 0,05480409 ! multicellular organismal metabolic process GO:0044236 19 19 1,000 0,01162691 0,05466428 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 0,01162691 0,05452519 ! cellular response to oxidative stress GO:0034599 19 19 1,000 0,01162691 0,0543868 ! positive regulation of T cell differentiation GO:0045582 19 19 1,000 0,01162691 0,05424911 ! peripheral nervous system development GO:0007422 19 19 1,000 0,01162691 0,05411212 ! regulation of protein stability GO:0031647 19 19 1,000 0,01162691 0,05397581 ! regulation of cell shape GO:0008360 21 19 1,000 0,01162691 0,0538402 ! placenta development GO:0001890 19 19 1,000 0,01162691 0,05370526 ! in utero embryonic development GO:0001701 55 55 2,000 0,01199621 0,05527253 ! regulation of cell adhesion GO:0030155 56 55 2,000 0,01199621 0,05513469 ! protein modification by small protein conjugation or removal GO:0070647 56 55 2,000 0,01199621 0,05499754 ! regulation of nervous system development GO:0051960 57 56 2,000 0,01259776 0,05761209 ! negative regulation of cell adhesion GO:0007162 21 20 1,000 0,01284691 0,05860609 ! negative regulation of binding GO:0051100 21 20 1,000 0,01284691 0,05846139 ! nucleus organization GO:0006997 20 20 1,000 0,01284691 0,05831739 ! phagocytosis GO:0006909 21 20 1,000 0,01284691 0,05817411 ! positive regulation of gene-specific transcription GO:0043193 20 20 1,000 0,01284691 0,05803152 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 1,000 0,01284691 0,05788964 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 0,01284691 0,05774844 ! regulation of B cell activation GO:0050864 20 20 1,000 0,01284691 0,05760794 ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 0,01412027 0,06316421 ! mammary gland development GO:0030879 23 21 1,000 0,01412027 0,06301127 ! Notch signaling pathway GO:0007219 22 21 1,000 0,01412027 0,06285907 ! DNA integrity checkpoint GO:0031570 21 21 1,000 0,01412027 0,0627076 ! regulation of action potential in neuron GO:0019228 21 21 1,000 0,01412027 0,06255686 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 1,000 0,01412027 0,06240684 ! regulation of proteolysis GO:0030162 21 21 1,000 0,01412027 0,06225755 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 0,01412027 0,06210896 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 1,000 0,01412027 0,06196108 ! cellular response to insulin stimulus GO:0032869 23 21 1,000 0,01412027 0,06181391 ! regulation of cell development GO:0060284 60 59 2,000 0,01450511 0,06334815 ! sister chromatid segregation GO:0000819 22 22 1,000 0,01544598 0,06729775 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 1,000 0,01544598 0,06713903 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! maintenance of protein location in cell GO:0032507 23 22 1,000 0,01544598 0,06698106 ! spindle organization GO:0007051 22 22 1,000 0,01544598 0,06682383 ! cell chemotaxis GO:0060326 23 22 1,000 0,01544598 0,06666733 GO:0030595|leukocyte chemotaxis, ! erythrocyte differentiation GO:0030218 23 22 1,000 0,01544598 0,06651156 ! male sex differentiation GO:0046661 22 22 1,000 0,01544598 0,06635653 ! biopolymer methylation GO:0043414 22 22 1,000 0,01544598 0,06620221 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 1,000 0,01544598 0,06604861 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 1,000 0,01544598 0,06589572 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 1,000 0,01544598 0,06574353 ! cytokinesis GO:0000910 23 22 1,000 0,01544598 0,06559205 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 1,000 0,01544598 0,06544126 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 2,000 0,01586289 0,06705344 ! axonogenesis GO:0007409 66 62 2,000 0,0165678 0,06987288 ! regulation of lymphocyte activation GO:0051249 62 62 2,000 0,0165678 0,06971335 ! regulation of hormone secretion GO:0046883 23 23 1,000 0,01682308 0,0706263 ! response to estrogen stimulus GO:0043627 23 23 1,000 0,01682308 0,07046578 ! mitotic cell cycle checkpoint GO:0007093 24 23 1,000 0,01682308 0,070306 ! endocrine system development GO:0035270 23 23 1,000 0,01682308 0,07014693 ! monovalent inorganic cation homeostasis GO:0055067 23 23 1,000 0,01682308 0,06998859 ! negative regulation of cellular component organization GO:0051129 65 63 2,000 0,01729011 0,07176955 ! angiogenesis GO:0001525 65 64 2,000 0,01802988 0,07467205 ! positive regulation of protein metabolic process GO:0051247 64 64 2,000 0,01802988 0,07450463 ! mitochondrial transport GO:0006839 24 24 1,000 0,0182506 0,07524801 ! regulation of action potential GO:0001508 24 24 1,000 0,0182506 0,07508004 ! gliogenesis GO:0042063 24 24 1,000 0,0182506 0,07491283 ! cellular amino acid biosynthetic process GO:0008652 24 24 1,000 0,0182506 0,07474636 ! T cell differentiation GO:0030217 24 24 1,000 0,0182506 0,07458062 ! nucleotide catabolic process GO:0009166 24 24 1,000 0,0182506 0,07441562 ! erythrocyte homeostasis GO:0034101 25 24 1,000 0,0182506 0,07425135 ! maintenance of protein location GO:0045185 25 24 1,000 0,0182506 0,0740878 ! androgen receptor signaling pathway GO:0030521 24 24 1,000 0,0182506 0,07392497 ! glucan metabolic process GO:0044042 25 24 1,000 0,0182506 0,07376285 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! positive regulation of cellular component organization GO:0051130 65 65 2,000 0,01878712 0,07576511 ! negative regulation of protein metabolic process GO:0051248 66 66 2,000 0,01956186 0,07871727 ! negative regulation of secretion GO:0051048 26 25 1,000 0,01972758 0,07921119 ! regulation of gene-specific transcription GO:0032583 25 25 1,000 0,01972758 0,079039 ! endosome transport GO:0016197 25 25 1,000 0,01972758 0,07886754 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 1,000 0,01972758 0,07869684 ! icosanoid metabolic process GO:0006690 25 25 1,000 0,01972758 0,07852686 ! negative regulation of immune system process GO:0002683 25 25 1,000 0,01972758 0,07835763 ! positive regulation of cytokine production GO:0001819 25 25 1,000 0,01972758 0,07818911 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 0,02035413 0,08049929 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! striated muscle tissue development GO:0014706 69 67 2,000 0,02035413 0,08032691 ! negative regulation of cell differentiation GO:0045596 68 67 2,000 0,02035413 0,08015527 ! regulation of cell size GO:0008361 68 68 2,000 0,02116395 0,08316666 ! positive regulation of defense response GO:0031349 26 26 1,000 0,02125309 0,08333925 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 0,02125309 0,0831623 ! negative regulation of cell migration GO:0030336 26 26 1,000 0,02125309 0,08298611 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 0,02125309 0,08281067 ! double-strand break repair GO:0006302 27 26 1,000 0,02125309 0,08263596 ! regulation of protein secretion GO:0050708 26 26 1,000 0,02125309 0,08246199 ! response to insulin stimulus GO:0032868 28 26 1,000 0,02125309 0,08228875 ! maintenance of location in cell GO:0051651 27 26 1,000 0,02125309 0,08211624 ! synapse organization GO:0050808 26 26 1,000 0,02125309 0,08194445 ! regionalization GO:0003002 70 69 2,000 0,02199133 0,08461381 ! regulation of leukocyte activation GO:0002694 69 69 2,000 0,02199133 0,08443753 ! regulation of mitotic cell cycle GO:0007346 72 69 2,000 0,02199133 0,08426198 ! energy reserve metabolic process GO:0006112 28 27 1,000 0,02282619 0,0872794 ! cAMP-mediated signaling GO:0019933 27 27 1,000 0,02282619 0,08709869 ! activation of caspase activity GO:0006919 27 27 1,000 0,02282619 0,08691874 ! mesenchymal cell development GO:0014031 29 27 1,000 0,02282619 0,08673952 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! defense response to bacterium GO:0042742 27 27 1,000 0,02282619 0,08656105 ! cell part morphogenesis GO:0032990 75 70 2,000 0,02283627 0,08642145 ! wound healing GO:0042060 74 70 2,000 0,02283627 0,08624435 ! muscle tissue development GO:0060537 72 70 2,000 0,02283627 0,08606798 ! carboxylic acid biosynthetic process GO:0046394 70 70 2,000 0,02283627 0,08589233 GO:0016053|organic acid biosynthetic process, ! ribosome biogenesis GO:0042254 71 71 2,000 0,02369878 0,0889549 ! regulation of cell activation GO:0050865 71 71 2,000 0,02369878 0,0887741 ! neuromuscular process GO:0050905 28 28 1,000 0,02444597 0,09138726 ! carbohydrate transport GO:0008643 28 28 1,000 0,02444597 0,09120227 ! unsaturated fatty acid metabolic process GO:0033559 28 28 1,000 0,02444597 0,09101802 ! histone modification GO:0016570 28 28 1,000 0,02444597 0,09083452 ! developmental growth GO:0048589 28 28 1,000 0,02444597 0,09065175 ! secretion by cell GO:0032940 75 72 2,000 0,02457887 0,09096155 ! positive regulation of hydrolase activity GO:0051345 72 72 2,000 0,02457887 0,09077926 ! leukocyte migration GO:0050900 30 29 1,000 0,02611152 0,09624706 ! regulation of gene expression, epigenetic GO:0040029 29 29 1,000 0,02611152 0,09605496 ! covalent chromatin modification GO:0016569 29 29 1,000 0,02611152 0,09586361 ! response to reactive oxygen species GO:0000302 31 30 1,000 0,02782195 0,10194007 ! positive regulation of peptidase activity GO:0010952 30 30 1,000 0,02782195 0,10173781 GO:0043280|positive regulation of caspase activity, ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,02782195 0,10153635 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 1,000 0,02782195 0,10133569 ! response to temperature stimulus GO:0009266 30 30 1,000 0,02782195 0,10113581 ! regulation of ossification GO:0030278 30 30 1,000 0,02782195 0,10093673 ! vascular process in circulatory system GO:0003018 31 30 1,000 0,02782195 0,10073842 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,02957638 0,10688093 ! B cell activation GO:0042113 31 31 1,000 0,02957638 0,10667177 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,02957638 0,10646342 ! aging GO:0007568 32 31 1,000 0,02957638 0,10625589 ! regulation of DNA replication GO:0006275 32 31 1,000 0,02957638 0,10604917 ! negative regulation of cell motion GO:0051271 31 31 1,000 0,02957638 0,10584325 ! regulation of protein modification process GO:0031399 79 78 2,000 0,03022782 0,10796486 ! muscle fiber development GO:0048747 32 32 1,000 0,03137394 0,11184173 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,03137394 0,11162582 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,03137394 0,11141074 ! protein maturation by peptide bond cleavage GO:0051605 32 32 1,000 0,03137394 0,11119649 ! maintenance of location GO:0051235 33 32 1,000 0,03137394 0,11098306 ! regulation of protein complex assembly GO:0043254 33 33 1,000 0,03321377 0,11726624 ! regulation of neuron differentiation GO:0045664 34 33 1,000 0,03321377 0,11704202 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,03321377 0,11681866 ! regulation of synaptic transmission GO:0050804 33 33 1,000 0,03321377 0,11659615 ! tube development GO:0035295 83 81 2,000 0,03328823 0,11663536 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 0,03509502 0,12273268 ! regulation of lipid metabolic process GO:0019216 34 34 1,000 0,03509502 0,12250023 ! response to peptide hormone stimulus GO:0043434 36 34 1,000 0,03509502 0,12226866 ! viral reproduction GO:0016032 34 34 1,000 0,03509502 0,12203797 ! ncRNA processing GO:0034470 83 83 2,000 0,0354153 0,12291976 ! acute inflammatory response GO:0002526 35 35 1,000 0,03701686 0,12823697 ! regulation of cytokine biosynthetic process GO:0042035 35 35 1,000 0,03701686 0,12799638 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,03701686 0,12775668 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,03701686 0,12751789 ! regulation of immune effector process GO:0002697 35 35 1,000 0,03701686 0,12727998 ! nitrogen compound biosynthetic process GO:0044271 86 85 2,000 0,03761141 0,12908347 ! positive regulation of cell differentiation GO:0045597 87 85 2,000 0,03761141 0,12884354 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,03761141 0,1286045 ! regulation of mitosis GO:0007088 37 36 1,000 0,03897846 0,13303203 GO:0051783|regulation of nuclear division, ! embryonic limb morphogenesis GO:0030326 36 36 1,000 0,03897846 0,13278613 GO:0035113|embryonic appendage morphogenesis, ! female pregnancy GO:0007565 37 36 1,000 0,03897846 0,13254114 ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,03897846 0,13229705 ! heterocycle catabolic process GO:0046700 36 36 1,000 0,03897846 0,13205385 ! regulation of transmission of nerve impulse GO:0051969 36 36 1,000 0,03897846 0,13181155 ! gonad development GO:0008406 36 36 1,000 0,03897846 0,13157014 ! regulation of lipase activity GO:0060191 36 36 1,000 0,03897846 0,13132961 ! coagulation GO:0050817 39 36 1,000 0,03897846 0,13108996 GO:0007596|blood coagulation, ! heart development GO:0007507 90 87 2,000 0,03987615 0,13386476 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 0,040979 0,13731691 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! meiosis GO:0007126 37 37 1,000 0,040979 0,1370677 GO:0051327|M phase of meiotic cell cycle, ! DNA damage response, signal transduction GO:0042770 37 37 1,000 0,040979 0,13681939 ! regulation of Rho protein signal transduction GO:0035023 37 37 1,000 0,040979 0,13657198 ! adaptive immune response GO:0002250 37 37 1,000 0,040979 0,13632546 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! chemotaxis GO:0006935 90 89 2,000 0,04220908 0,14016458 GO:0042330|taxis, ! rRNA transcription GO:0009303 5 5 0,000 0,04286295 0,1420799 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,04286295 0,14182482 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,04286295 0,14157065 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,04286295 0,14131739 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,04286295 0,14106504 ! reproductive cellular process GO:0048610 5 5 0,000 0,04286295 0,14081359 ! positive regulation of glucose metabolic process GO:0010907 5 5 0,000 0,04286295 0,14056303 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,04286295 0,14031336 ! prostate gland development GO:0030850 5 5 0,000 0,04286295 0,14006458 ! metencephalon development GO:0022037 5 5 0,000 0,04286295 0,13981668 ! water transport GO:0006833 5 5 0,000 0,04286295 0,13956965 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,04286295 0,1393235 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,04286295 0,13907821 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,04286295 0,13883378 ! glycerol metabolic process GO:0006071 5 5 0,000 0,04286295 0,13859022 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,04286295 0,1383475 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,04286295 0,13810563 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,04286295 0,13786461 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,04286295 0,13762443 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,04286295 0,13738508 ! CTP metabolic process GO:0046036 5 5 0,000 0,04286295 0,13714657 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,04286295 0,13690888 ! GTP metabolic process GO:0046039 5 5 0,000 0,04286295 0,13667201 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,04286295 0,13643596 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,04286295 0,13620073 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,04286295 0,1359663 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,04286295 0,13573269 ! social behavior GO:0035176 5 5 0,000 0,04286295 0,13549987 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,04286295 0,13526785 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,04286295 0,13503662 ! memory GO:0007613 5 5 0,000 0,04286295 0,13480618 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,04286295 0,13457653 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,04286295 0,13434766 ! response to lipid GO:0033993 5 5 0,000 0,04286295 0,13411956 ! hippocampus development GO:0021766 6 5 0,000 0,04286295 0,13389224 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,04286295 0,13366569 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,04286295 0,1334399 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,04286295 0,13321488 ! mechanosensory behavior GO:0007638 5 5 0,000 0,04286295 0,13299061 ! heart looping GO:0001947 5 5 0,000 0,04286295 0,1327671 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,04286295 0,13254433 ! response to interferon-gamma GO:0034341 5 5 0,000 0,04286295 0,13232232 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,04286295 0,13210104 ! pH reduction GO:0045851 5 5 0,000 0,04286295 0,13188051 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,04286295 0,13166071 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,04286295 0,13144164 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,04286295 0,13122329 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,04286295 0,13100568 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,04286295 0,13078878 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,04286295 0,1305726 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,04286295 0,13035713 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,04286295 0,13014238 ! adrenal gland development GO:0030325 5 5 0,000 0,04286295 0,12992833 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,04286295 0,12971498 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,04286295 0,12950233 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,04286295 0,12929038 ! astrocyte differentiation GO:0048708 5 5 0,000 0,04286295 0,12907912 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,04286295 0,12886855 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,04286295 0,12865867 ! tyrosine metabolic process GO:0006570 5 5 0,000 0,04286295 0,12844947 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,04286295 0,12824095 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,04286295 0,1280331 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,04286295 0,12782593 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,04286295 0,12761942 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,04286295 0,12741359 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,04286295 0,12720841 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,04286295 0,1270039 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,04286295 0,12680004 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,04286295 0,12659683 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,04286295 0,12639428 ! response to ATP GO:0033198 5 5 0,000 0,04286295 0,12619237 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,04286295 0,12599111 ! regulation of appetite GO:0032098 5 5 0,000 0,04286295 0,12579048 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,04286295 0,1255905 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,04286295 0,12539115 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,04286295 0,12519243 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,04286295 0,12499434 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04286295 0,12479688 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,04286295 0,12460004 ! fear response GO:0042596 5 5 0,000 0,04286295 0,12440382 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,04286295 0,12420821 ! retinol metabolic process GO:0042572 5 5 0,000 0,04286295 0,12401322 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,04286295 0,12381884 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,04286295 0,12362508 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,04286295 0,12343191 ! parturition GO:0007567 5 5 0,000 0,04286295 0,12323935 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,04286295 0,12304739 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,04286295 0,12285602 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,04286295 0,12266525 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,04286295 0,12247507 ! protein heterooligomerization GO:0051291 5 5 0,000 0,04286295 0,12228548 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,04286295 0,12209648 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,04286295 0,12190806 ! response to UV-B GO:0010224 5 5 0,000 0,04286295 0,12172022 ! oligodendrocyte development GO:0014003 5 5 0,000 0,04286295 0,12153296 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,04286295 0,12134627 ! activated T cell proliferation GO:0050798 5 5 0,000 0,04286295 0,12116016 ! interaction with symbiont GO:0051702 5 5 0,000 0,04286295 0,12097461 ! cellular extravasation GO:0045123 5 5 0,000 0,04286295 0,12078964 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,04286295 0,12060523 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,04286295 0,12042138 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,04286295 0,12023809 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,04286295 0,12005535 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,04286295 0,11987318 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,04286295 0,11969155 ! response to amine stimulus GO:0014075 5 5 0,000 0,04286295 0,11951047 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,04286295 0,11932994 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,04286295 0,11914996 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,04286295 0,11897052 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,04286295 0,11879161 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,04286295 0,11861325 ! neuron recognition GO:0008038 5 5 0,000 0,04286295 0,11843542 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,04286295 0,11825812 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,04286295 0,11808135 ! regulation of mitochondrial membrane potential GO:0051881 5 5 0,000 0,04286295 0,11790511 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,04286295 0,11772939 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,04286295 0,1175542 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,04286295 0,11737953 ! cellular pigmentation GO:0033059 5 5 0,000 0,04286295 0,11720538 ! histone methylation GO:0016571 5 5 0,000 0,04286295 0,11703174 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04286295 0,11685861 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,04286295 0,116686 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,04286295 0,1165139 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,04286295 0,1163423 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,04286295 0,11617121 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,04286295 0,11600062 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,04286295 0,11583053 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,04286295 0,11566094 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,04286295 0,11549185 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,04286295 0,11532325 ! sterol catabolic process GO:0016127 5 5 0,000 0,04286295 0,11515514 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,04286295 0,11498752 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,04286295 0,11482038 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,04286295 0,11465373 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,04286295 0,11448757 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,04286295 0,11432189 ! zymogen activation GO:0031638 5 5 0,000 0,04286295 0,11415668 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,04286295 0,11399195 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,04286295 0,1138277 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,04286295 0,11366392 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,04286295 0,11350061 ! nucleosome positioning GO:0016584 5 5 0,000 0,04286295 0,11333777 ! regulation of isotype switching GO:0045191 5 5 0,000 0,04286295 0,11317539 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,04286295 0,11301348 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,04286295 0,11285203 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,04286295 0,11269105 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,04286295 0,11253052 ! NADPH regeneration GO:0006740 5 5 0,000 0,04286295 0,11237045 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,04286295 0,11221083 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,04286295 0,11205166 ! musculoskeletal movement GO:0050881 5 5 0,000 0,04286295 0,11189295 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,04286295 0,11173469 ! sarcomere organization GO:0045214 5 5 0,000 0,04286295 0,11157687 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,04286295 0,1114195 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,04286295 0,11126257 GO:0046325|negative regulation of glucose import, ! oocyte differentiation GO:0009994 5 5 0,000 0,04286295 0,11110608 GO:0048599|oocyte development, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,04286295 0,11095003 ! regulation of protein homodimerization activity GO:0043496 6 5 0,000 0,04286295 0,11079442 ! spleen development GO:0048536 5 5 0,000 0,04286295 0,11063925 ! male genitalia development GO:0030539 5 5 0,000 0,04286295 0,11048451 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,04286295 0,1103302 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,04286295 0,11017632 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,04286295 0,11002287 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,04286295 0,10986985 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,04286295 0,10971725 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,04286295 0,10956508 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,04286295 0,10941333 ! ATP catabolic process GO:0006200 5 5 0,000 0,04286295 0,109262 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04286295 0,10911108 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,04286295 0,10896058 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,04286295 0,1088105 ! embryonic gut development GO:0048566 5 5 0,000 0,04286295 0,10866083 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,04286295 0,10851157 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,04286295 0,10836272 ! activation of innate immune response GO:0002218 5 5 0,000 0,04286295 0,10821428 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,04286295 0,10806624 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,04286295 0,10791861 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,04286295 0,10777138 ! muscle adaptation GO:0043500 5 5 0,000 0,04286295 0,10762455 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,04286295 0,10747813 ! embryonic heart tube development GO:0035050 5 5 0,000 0,04286295 0,1073321 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,04286295 0,10718646 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,04286295 0,10704122 ! defense response to fungus GO:0050832 5 5 0,000 0,04286295 0,10689638 ! lysogeny GO:0030069 5 5 0,000 0,04286295 0,10675192 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,04286295 0,10660786 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,04286295 0,10646418 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,04286295 0,10632089 ! response to nicotine GO:0035094 5 5 0,000 0,04286295 0,10617799 ! establishment of cell polarity GO:0030010 5 5 0,000 0,04286295 0,10603547 ! mitochondrion localization GO:0051646 5 5 0,000 0,04286295 0,10589333 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,04286295 0,10575157 ! positive regulation of secretion GO:0051047 39 38 1,000 0,04301769 0,10599145 ! exocytosis GO:0006887 40 38 1,000 0,04301769 0,10584994 ! urogenital system development GO:0001655 38 38 1,000 0,04301769 0,10570881 ! meiotic cell cycle GO:0051321 38 38 1,000 0,04301769 0,10556805 ! axon guidance GO:0007411 39 38 1,000 0,04301769 0,10542767 ! regulation of neurological system process GO:0031644 38 38 1,000 0,04301769 0,10528766 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 0,04301769 0,10514802 ! regulation of homeostatic process GO:0032844 38 38 1,000 0,04301769 0,10500875 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,04509373 0,10993088 ! hemostasis GO:0007599 42 39 1,000 0,04509373 0,10978567 ! positive regulation of protein modification process GO:0031401 39 39 1,000 0,04509373 0,10964083 ! fatty acid biosynthetic process GO:0006633 39 39 1,000 0,04509373 0,10949638 ! nucleotide-excision repair GO:0006289 40 39 1,000 0,04509373 0,1093523 ! regulation of MAPKKK cascade GO:0043408 41 39 1,000 0,04509373 0,10920861 ! positive regulation of T cell activation GO:0050870 39 39 1,000 0,04509373 0,10906529 ! lymphocyte differentiation GO:0030098 39 39 1,000 0,04509373 0,10892234 ! limb development GO:0060173 39 39 1,000 0,04509373 0,10877978 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! positive regulation of immune system process GO:0002684 92 92 2,000 0,04583522 0,11042393 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,04720634 0,1135787 ! DNA catabolic process GO:0006308 41 40 1,000 0,04720634 0,11343062 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 0,04720634 0,11328292 ! regulation of response to stress GO:0080134 97 94 2,000 0,04833633 0,11584375 ! pattern specification process GO:0007389 96 94 2,000 0,04833633 0,11569331 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,04935474 0,11797768 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cell cycle checkpoint GO:0000075 42 41 1,000 0,04935474 0,11782486 ! leukocyte mediated immunity GO:0002443 41 41 1,000 0,04935474 0,11767244 ! regulation of cell growth GO:0001558 97 96 2,000 0,05090368 0,12120864 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,05121615 0,12179531 ! axon extension GO:0048675 7 6 0,000 0,05121615 0,12163835 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,05121615 0,12148181 ! tRNA modification GO:0006400 6 6 0,000 0,05121615 0,12132566 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,05121615 0,12116991 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,05121615 0,12101457 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,05121615 0,12085962 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,05121615 0,12070507 ! virus-host interaction GO:0019048 6 6 0,000 0,05121615 0,12055091 ! regulation of S phase GO:0033261 6 6 0,000 0,05121615 0,12039715 ! myotube differentiation GO:0014902 6 6 0,000 0,05121615 0,12024377 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,05121615 0,12009079 ! bone remodeling GO:0046849 6 6 0,000 0,05121615 0,1199382 ! N-glycan processing GO:0006491 6 6 0,000 0,05121615 0,11978599 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,05121615 0,11963417 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,05121615 0,11948274 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,05121615 0,11933169 ! RNA methylation GO:0001510 6 6 0,000 0,05121615 0,11918101 ! cartilage condensation GO:0001502 7 6 0,000 0,05121615 0,11903072 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,05121615 0,11888081 ! succinate metabolic process GO:0006105 7 6 0,000 0,05121615 0,11873127 ! artery development GO:0060840 6 6 0,000 0,05121615 0,11858211 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,05121615 0,11843333 ! bile acid metabolic process GO:0008206 6 6 0,000 0,05121615 0,11828492 ! androgen metabolic process GO:0008209 6 6 0,000 0,05121615 0,11813688 ! estrogen metabolic process GO:0008210 6 6 0,000 0,05121615 0,1179892 ! limbic system development GO:0021761 7 6 0,000 0,05121615 0,1178419 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,05121615 0,11769497 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,05121615 0,1175484 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,05121615 0,11740219 ! pathogenesis GO:0009405 6 6 0,000 0,05121615 0,11725635 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,05121615 0,11711087 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,05121615 0,11696575 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,05121615 0,11682099 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,05121615 0,11667659 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,05121615 0,11653255 ! arginine metabolic process GO:0006525 6 6 0,000 0,05121615 0,11638886 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,05121615 0,11624552 ! glutamate catabolic process GO:0006538 7 6 0,000 0,05121615 0,11610254 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,05121615 0,11595991 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,05121615 0,11581762 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,05121615 0,11567569 GO:0005978|glycogen biosynthetic process, ! V(D)J recombination GO:0033151 6 6 0,000 0,05121615 0,1155341 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,05121615 0,11539286 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,05121615 0,11525197 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,05121615 0,11511142 ! regulation of heart rate GO:0002027 6 6 0,000 0,05121615 0,11497121 ! lipid digestion GO:0044241 6 6 0,000 0,05121615 0,11483134 ! asymmetric protein localization GO:0008105 6 6 0,000 0,05121615 0,11469181 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,05121615 0,11455263 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,05121615 0,11441377 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,05121615 0,11427526 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,05121615 0,11413708 ! ruffle organization GO:0031529 6 6 0,000 0,05121615 0,11399923 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,05121615 0,11386172 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,05121615 0,11372453 ! neutral amino acid transport GO:0015804 6 6 0,000 0,05121615 0,11358768 ! L-amino acid transport GO:0015807 6 6 0,000 0,05121615 0,11345116 ! bone mineralization GO:0030282 6 6 0,000 0,05121615 0,11331496 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,05121615 0,11317909 ! negative regulation of ossification GO:0030279 6 6 0,000 0,05121615 0,11304355 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,05121615 0,11290833 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,05121615 0,11277343 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,05121615 0,11263886 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,05121615 0,1125046 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,05121615 0,11237067 ! regulation of organ growth GO:0046620 6 6 0,000 0,05121615 0,11223706 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,05121615 0,11210376 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,05121615 0,11197078 ! response to dsRNA GO:0043331 6 6 0,000 0,05121615 0,11183811 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,05121615 0,11170576 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,05121615 0,11157372 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,05121615 0,11144199 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,05121615 0,11131057 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,05121615 0,11117946 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,05121615 0,11104866 ! multicellular organismal aging GO:0010259 6 6 0,000 0,05121615 0,11091817 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,05121615 0,11078799 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,05121615 0,1106581 ! renal water homeostasis GO:0003091 6 6 0,000 0,05121615 0,11052853 ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,05121615 0,11039926 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,05121615 0,11027028 ! ribosome assembly GO:0042255 6 6 0,000 0,05121615 0,11014161 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,05121615 0,11001324 ! diencephalon development GO:0021536 6 6 0,000 0,05121615 0,10988517 ! fucose catabolic process GO:0019317 6 6 0,000 0,05121615 0,1097574 GO:0042355|L-fucose catabolic process, ! regulation of lipid transport GO:0032368 6 6 0,000 0,05121615 0,10962992 ! regulation of cell division GO:0051302 6 6 0,000 0,05121615 0,10950274 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,05121615 0,10937586 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,05121615 0,10924926 ! neuroblast proliferation GO:0007405 6 6 0,000 0,05121615 0,10912296 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,05121615 0,10899696 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,05121615 0,10887124 ! regulation of glucose transport GO:0010827 6 6 0,000 0,05121615 0,10874581 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,05121615 0,10862067 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,05121615 0,10849582 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,05121615 0,10837126 ! thymus development GO:0048538 6 6 0,000 0,05121615 0,10824698 ! lymph node development GO:0048535 6 6 0,000 0,05121615 0,10812298 ! organic cation transport GO:0015695 6 6 0,000 0,05121615 0,10799927 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,05121615 0,10787584 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,05121615 0,1077527 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 0,000 0,05121615 0,10762983 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,05121615 0,10750725 ! sperm-egg recognition GO:0035036 7 6 0,000 0,05121615 0,10738494 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,05121615 0,10726291 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,05121615 0,10714116 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,05121615 0,10701969 ! alditol metabolic process GO:0019400 6 6 0,000 0,05121615 0,10689849 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,05121615 0,10677756 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,05121615 0,10665691 ! regulation of embryonic development GO:0045995 6 6 0,000 0,05121615 0,10653653 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,05121615 0,10641642 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,05153818 0,10696495 ! development of primary sexual characteristics GO:0045137 42 42 1,000 0,05153818 0,10684463 ! protein ubiquitination GO:0016567 43 42 1,000 0,05153818 0,10672458 ! one-carbon metabolic process GO:0006730 42 42 1,000 0,05153818 0,1066048 ! endocytosis GO:0006897 99 98 2,000 0,05353665 0,11061439 GO:0010324|membrane invagination, ! reproductive structure development GO:0048608 43 43 1,000 0,05375591 0,11094304 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 1,000 0,05375591 0,11081894 ! mitochondrion organization GO:0007005 44 43 1,000 0,05375591 0,11069512 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,05375591 0,11057158 ! humoral immune response GO:0006959 44 44 1,000 0,05600717 0,11507381 ! protein import into nucleus GO:0006606 44 44 1,000 0,05600717 0,11494567 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,05600717 0,11481781 ! positive regulation of lymphocyte activation GO:0051251 44 44 1,000 0,05600717 0,11469024 ! muscle organ development GO:0007517 102 100 2,000 0,05623453 0,11502802 ! amine biosynthetic process GO:0009309 46 45 1,000 0,05829124 0,11910284 ! homophilic cell adhesion GO:0007156 45 45 1,000 0,05829124 0,11897094 ! nuclear import GO:0051170 45 45 1,000 0,05829124 0,11883933 ! protein processing GO:0016485 45 45 1,000 0,05829124 0,11870802 ! respiratory burst GO:0045730 7 7 0,000 0,05949765 0,12103109 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,05949765 0,12089765 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,05949765 0,1207645 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,05949765 0,12063165 ! positive regulation of cellular catabolic process GO:0031331 7 7 0,000 0,05949765 0,12049909 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,05949765 0,12036681 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,05949765 0,12023483 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,05949765 0,12010314 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,05949765 0,11997174 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,05949765 0,11984062 GO:0043241|protein complex disassembly, ! hair follicle morphogenesis GO:0031069 7 7 0,000 0,05949765 0,11970979 ! gene silencing by RNA GO:0031047 7 7 0,000 0,05949765 0,11957925 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,05949765 0,11944898 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,05949765 0,11931901 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,05949765 0,11918931 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,05949765 0,1190599 ! axis specification GO:0009798 7 7 0,000 0,05949765 0,11893077 ! visual behavior GO:0007632 7 7 0,000 0,05949765 0,11880192 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,05949765 0,11867334 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,05949765 0,11854505 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,05949765 0,11841703 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,05949765 0,11828929 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,05949765 0,11816182 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,05949765 0,11803463 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,05949765 0,11790771 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,05949765 0,11778106 ! digestive system development GO:0055123 7 7 0,000 0,05949765 0,11765469 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,05949765 0,11752858 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,05949765 0,11740275 ! protein targeting to ER GO:0045047 8 7 0,000 0,05949765 0,11727718 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,05949765 0,11715189 ! endoderm development GO:0007492 7 7 0,000 0,05949765 0,11702686 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,05949765 0,1169021 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,05949765 0,1167776 GO:0006688|glycosphingolipid biosynthetic process, ! response to hexose stimulus GO:0009746 7 7 0,000 0,05949765 0,11665337 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,05949765 0,1165294 ! regulation of skeletal muscle fiber development GO:0048742 7 7 0,000 0,05949765 0,1164057 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,05949765 0,11628226 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,05949765 0,11615908 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,05949765 0,11603616 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,05949765 0,1159135 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,05949765 0,1157911 ! UV protection GO:0009650 7 7 0,000 0,05949765 0,11566895 ! DNA integration GO:0015074 7 7 0,000 0,05949765 0,11554707 ! myofibril assembly GO:0030239 7 7 0,000 0,05949765 0,11542544 GO:0055002|striated muscle cell development, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 0,000 0,05949765 0,11530407 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,05949765 0,11518295 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,05949765 0,11506209 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,05949765 0,11494148 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,05949765 0,11482112 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,05949765 0,11470101 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,05949765 0,11458116 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,05949765 0,11446155 GO:0019827|stem cell maintenance, ! alpha-beta T cell differentiation GO:0046632 7 7 0,000 0,05949765 0,1143422 ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,05949765 0,11422309 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,05949765 0,11410423 ! axon cargo transport GO:0008088 7 7 0,000 0,05949765 0,11398562 ! eating behavior GO:0042755 7 7 0,000 0,05949765 0,11386726 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,05949765 0,11374914 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,05949765 0,11363126 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,05949765 0,11351363 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,05949765 0,11339624 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,05949765 0,1132791 ! cranial nerve development GO:0021545 7 7 0,000 0,05949765 0,1131622 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,05949765 0,11304553 ! induction of an organ GO:0001759 7 7 0,000 0,05949765 0,11292911 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,05949765 0,11281293 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,05949765 0,11269699 ! autonomic nervous system development GO:0048483 7 7 0,000 0,05949765 0,11258128 ! intracellular lipid transport GO:0032365 7 7 0,000 0,05949765 0,11246581 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,05949765 0,11235058 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,05949765 0,11223559 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,05949765 0,11212083 ! natural killer cell activation GO:0030101 7 7 0,000 0,05949765 0,1120063 ! NADP metabolic process GO:0006739 7 7 0,000 0,05949765 0,11189201 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,05949765 0,11177795 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,05949765 0,11166412 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,05949765 0,11155053 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,05949765 0,11143716 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,05949765 0,11132403 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,05949765 0,11121112 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,05949765 0,11109845 ! cell-cell recognition GO:0009988 8 7 0,000 0,05949765 0,110986 ! hormone catabolic process GO:0042447 7 7 0,000 0,05949765 0,11087378 ! dopamine metabolic process GO:0042417 7 7 0,000 0,05949765 0,11076179 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,05949765 0,11065002 ! oxygen transport GO:0015671 7 7 0,000 0,05949765 0,11053848 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,05949765 0,11042716 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,05949765 0,11031606 ! regulation of axon extension GO:0030516 7 7 0,000 0,05949765 0,11020519 ! cell killing GO:0001906 7 7 0,000 0,05949765 0,11009455 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,05949765 0,10998412 ! adult feeding behavior GO:0008343 7 7 0,000 0,05949765 0,10987392 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,05949765 0,10976393 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,05949765 0,10965417 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 1,000 0,0606074 0,11158786 ! cellular response to hormone stimulus GO:0032870 48 46 1,000 0,0606074 0,11147649 ! regulation of membrane potential GO:0042391 46 46 1,000 0,0606074 0,11136535 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 1,000 0,06295494 0,1155637 ! regulation of blood pressure GO:0008217 48 47 1,000 0,06295494 0,11544871 ! sex differentiation GO:0007548 47 47 1,000 0,06295494 0,11533395 ! regulation of cell cycle process GO:0010564 50 48 1,000 0,06533315 0,119572 ! protein localization in nucleus GO:0034504 48 48 1,000 0,06533315 0,11945337 ! regulation of skeletal muscle tissue development GO:0048641 8 8 0,000 0,06770806 0,1236729 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,06770806 0,12355045 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,06770806 0,12342824 ! superoxide anion generation GO:0042554 8 8 0,000 0,06770806 0,12330628 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,06770806 0,12318455 ! cGMP metabolic process GO:0046068 8 8 0,000 0,06770806 0,12306307 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,06770806 0,12294182 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,06770806 0,12282082 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,06770806 0,12270005 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,06770806 0,12257952 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,06770806 0,12245923 ! zinc ion transport GO:0006829 8 8 0,000 0,06770806 0,12233917 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,06770806 0,12221935 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,06770806 0,12209976 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,06770806 0,1219804 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,06770806 0,12186128 ! lipid localization GO:0010876 8 8 0,000 0,06770806 0,12174239 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,06770806 0,12162373 ! response to cAMP GO:0051591 8 8 0,000 0,06770806 0,12150531 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,06770806 0,12138711 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,06770806 0,12126915 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,06770806 0,12115141 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,06770806 0,1210339 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,06770806 0,12091662 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,06770806 0,12079957 ! sensory perception of taste GO:0050909 8 8 0,000 0,06770806 0,12068274 ! organelle fusion GO:0048284 8 8 0,000 0,06770806 0,12056614 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,06770806 0,12044976 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! T cell selection GO:0045058 8 8 0,000 0,06770806 0,12033361 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,06770806 0,12021768 ! sperm motility GO:0030317 8 8 0,000 0,06770806 0,12010197 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,06770806 0,11998649 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,06770806 0,11987123 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,06770806 0,11975619 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,06770806 0,11964137 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,06770806 0,11952677 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,06770806 0,11941239 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,06770806 0,11929823 ! Golgi organization GO:0007030 8 8 0,000 0,06770806 0,11918429 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,06770806 0,11907056 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,06770806 0,11895706 ! fructose metabolic process GO:0006000 8 8 0,000 0,06770806 0,11884376 ! mannose metabolic process GO:0006013 9 8 0,000 0,06770806 0,11873069 ! NAD metabolic process GO:0019674 8 8 0,000 0,06770806 0,11861782 ! negative regulation of mitotic cell cycle GO:0045930 9 8 0,000 0,06770806 0,11850518 ! response to fungus GO:0009620 8 8 0,000 0,06770806 0,11839274 ! stem cell differentiation GO:0048863 8 8 0,000 0,06770806 0,11828052 ! alpha-beta T cell activation GO:0046631 8 8 0,000 0,06770806 0,11816851 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,06770806 0,11805672 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,06770806 0,11794513 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,06770806 0,11783376 ! regulation of vasodilation GO:0042312 8 8 0,000 0,06770806 0,1177226 ! vasoconstriction GO:0042310 8 8 0,000 0,06770806 0,11761164 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,06770806 0,1175009 ! muscle cell development GO:0055001 8 8 0,000 0,06770806 0,11739036 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,06770806 0,11728003 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,06770806 0,11716991 ! sensory perception of pain GO:0019233 8 8 0,000 0,06770806 0,11705999 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,06770806 0,11695028 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,06770806 0,11684078 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,06770806 0,11673148 ! chromatin silencing GO:0006342 8 8 0,000 0,06770806 0,11662238 ! tissue regeneration GO:0042246 8 8 0,000 0,06770806 0,11651349 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,06770806 0,11640481 ! T cell homeostasis GO:0043029 8 8 0,000 0,06770806 0,11629632 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,06770806 0,11618804 ! water homeostasis GO:0030104 8 8 0,000 0,06770806 0,11607995 ! cofactor transport GO:0051181 8 8 0,000 0,06770806 0,11597207 ! acid secretion GO:0046717 8 8 0,000 0,06770806 0,11586439 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,06770806 0,11575691 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,06770806 0,11564963 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,06770806 0,11554255 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,06770806 0,11543566 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,06770806 0,11532898 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 0,000 0,06770806 0,11522249 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,06770806 0,11511619 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,06770806 0,11501009 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,06770806 0,11490419 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,06770806 0,11479848 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,06770806 0,11469297 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,06770806 0,11458765 ! developmental induction GO:0031128 8 8 0,000 0,06770806 0,11448252 GO:0045168|cell-cell signaling involved in cell fate specification, ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,06770806 0,11437759 ! actin filament polymerization GO:0030041 9 8 0,000 0,06770806 0,11427285 ! peptide hormone processing GO:0016486 8 8 0,000 0,06770806 0,1141683 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,06770806 0,11406394 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,06770806 0,11395977 ! ossification GO:0001503 50 49 1,000 0,06774134 0,11391177 GO:0060348|bone development, ! positive regulation of cell activation GO:0050867 49 49 1,000 0,06774134 0,11380793 GO:0002696|positive regulation of leukocyte activation, ! regulation of DNA metabolic process GO:0051052 51 50 1,000 0,07017883 0,11779562 ! T cell activation GO:0042110 51 50 1,000 0,07017883 0,11768844 ! protein maturation GO:0051604 51 51 1,000 0,07264495 0,12171331 ! regulation of body fluid levels GO:0050878 55 52 1,000 0,07513902 0,12577767 ! lactation GO:0007595 10 9 0,000 0,07584798 0,1268492 ! embryonic pattern specification GO:0009880 10 9 0,000 0,07584798 0,1267342 ! positive regulation of cell size GO:0045793 9 9 0,000 0,07584798 0,1266194 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,07584798 0,12650481 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,07584798 0,12639043 ! viral genome replication GO:0019079 9 9 0,000 0,07584798 0,12627626 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,07584798 0,12616229 ! copper ion transport GO:0006825 9 9 0,000 0,07584798 0,12604853 ! lipid phosphorylation GO:0046834 9 9 0,000 0,07584798 0,12593497 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,07584798 0,12582162 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,07584798 0,12570847 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,07584798 0,12559553 ! RNA polyadenylation GO:0043631 9 9 0,000 0,07584798 0,12548278 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,07584798 0,12537024 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,07584798 0,1252579 ! phospholipid efflux GO:0033700 9 9 0,000 0,07584798 0,12514577 ! response to alkaloid GO:0043279 10 9 0,000 0,07584798 0,12503383 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,07584798 0,12492209 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,07584798 0,12481055 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,07584798 0,12469922 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,07584798 0,12458808 ! response to ethanol GO:0045471 9 9 0,000 0,07584798 0,12447713 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,07584798 0,12436639 ! activation of pro-apoptotic gene products GO:0008633 9 9 0,000 0,07584798 0,12425584 ! methionine metabolic process GO:0006555 9 9 0,000 0,07584798 0,12414549 ! glutamine metabolic process GO:0006541 9 9 0,000 0,07584798 0,12403533 ! cerebral cortex development GO:0021987 9 9 0,000 0,07584798 0,12392537 ! response to osmotic stress GO:0006970 9 9 0,000 0,07584798 0,12381561 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,07584798 0,12370604 ! central nervous system neuron development GO:0021954 10 9 0,000 0,07584798 0,12359666 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,07584798 0,12348747 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,07584798 0,12337848 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,07584798 0,12326968 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,07584798 0,12316108 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,07584798 0,12305266 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 0,000 0,07584798 0,12294443 GO:0060675|ureteric bud morphogenesis, ! L-glutamate transport GO:0015813 9 9 0,000 0,07584798 0,1228364 GO:0015800|acidic amino acid transport, ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,07584798 0,12272855 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,07584798 0,1226209 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,07584798 0,12251343 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,07584798 0,12240615 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,07584798 0,12229906 ! DNA replication initiation GO:0006270 9 9 0,000 0,07584798 0,12219215 ! T cell differentiation in the thymus GO:0033077 9 9 0,000 0,07584798 0,12208543 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,07584798 0,1219789 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,07584798 0,12187255 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,07584798 0,12176639 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,07584798 0,12166042 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,07584798 0,12155463 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,07584798 0,12144902 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,07584798 0,12134359 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,07584798 0,12123835 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,07584798 0,12113329 ! purine base metabolic process GO:0006144 9 9 0,000 0,07584798 0,12102842 ! gas transport GO:0015669 9 9 0,000 0,07584798 0,12092372 ! cholesterol efflux GO:0033344 9 9 0,000 0,07584798 0,12081921 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,07584798 0,12071487 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,07584798 0,12061072 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,07584798 0,12050674 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,07584798 0,12040295 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,07584798 0,12029933 ! actin filament-based movement GO:0030048 9 9 0,000 0,07584798 0,12019589 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,07584798 0,12009263 ! response to virus GO:0009615 54 54 1,000 0,08020842 0,12688766 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,08278247 0,13084742 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,083918 0,1325286 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,083918 0,13241513 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,083918 0,13230186 ! regulation of glucose metabolic process GO:0010906 10 10 0,000 0,083918 0,13218878 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,083918 0,13207589 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,083918 0,1319632 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,083918 0,1318507 ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,083918 0,13173839 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,083918 0,13162627 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,083918 0,13151435 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,083918 0,13140261 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,083918 0,13129106 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inositol metabolic process GO:0006020 10 10 0,000 0,083918 0,1311797 ! cAMP metabolic process GO:0046058 10 10 0,000 0,083918 0,13106853 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,083918 0,13095755 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,083918 0,13084676 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,083918 0,13073615 ! glial cell development GO:0021782 10 10 0,000 0,083918 0,13062574 ! phototransduction GO:0007602 11 10 0,000 0,083918 0,1305155 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,083918 0,13040546 ! fat cell differentiation GO:0045444 10 10 0,000 0,083918 0,13029559 ! myoblast differentiation GO:0045445 10 10 0,000 0,083918 0,13018592 ! centrosome cycle GO:0007098 10 10 0,000 0,083918 0,13007643 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,083918 0,12996712 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,083918 0,12985799 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,083918 0,12974905 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,083918 0,12964029 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,083918 0,12953172 ! epidermis morphogenesis GO:0048730 10 10 0,000 0,083918 0,12942332 ! protein polyubiquitination GO:0000209 10 10 0,000 0,083918 0,12931511 ! glutamate metabolic process GO:0006536 11 10 0,000 0,083918 0,12920708 ! plasma membrane organization GO:0007009 10 10 0,000 0,083918 0,12909922 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,083918 0,12899155 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,083918 0,12888406 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,083918 0,12877675 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,083918 0,12866961 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,083918 0,12856265 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,083918 0,12845587 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,083918 0,12834927 ! embryo implantation GO:0007566 11 10 0,000 0,083918 0,12824285 ! regulation of protein binding GO:0043393 11 10 0,000 0,083918 0,1281366 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,083918 0,12803052 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,083918 0,12792462 GO:0070585|protein localization in mitochondrion, ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,083918 0,1278189 ! protein export from nucleus GO:0006611 10 10 0,000 0,083918 0,12771335 ! negative regulation of immune response GO:0050777 10 10 0,000 0,083918 0,12760798 ! cytolysis GO:0019835 10 10 0,000 0,083918 0,12750278 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,083918 0,12739775 GO:0030501|positive regulation of bone mineralization, ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,083918 0,1272929 ! histone deacetylation GO:0016575 10 10 0,000 0,083918 0,12718822 ! mRNA splice site selection GO:0006376 11 10 0,000 0,083918 0,12708371 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,083918 0,12697937 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,083918 0,1268752 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,083918 0,12677121 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,083918 0,12666738 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,083918 0,12656372 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,083918 0,12646024 ! regulation of epidermis development GO:0045682 10 10 0,000 0,083918 0,12635692 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,083918 0,12625377 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,083918 0,12615079 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,083918 0,12604798 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,083918 0,12594533 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,083918 0,12584286 ! lymphocyte homeostasis GO:0002260 10 10 0,000 0,083918 0,12574055 ! nerve development GO:0021675 10 10 0,000 0,083918 0,1256384 ! gut development GO:0048565 10 10 0,000 0,083918 0,12553642 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,083918 0,12543461 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,083918 0,12533296 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,083918 0,12523147 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,083918 0,12513015 ! reproductive developmental process GO:0003006 56 56 1,000 0,0853819 0,12721006 ! extracellular structure organization GO:0043062 56 56 1,000 0,0853819 0,1271073 ! protein secretion GO:0009306 11 11 0,000 0,09191871 0,13672816 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,09191871 0,1366179 ! negative regulation of defense response GO:0031348 11 11 0,000 0,09191871 0,13650781 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,09191871 0,1363979 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,09191871 0,13628817 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,09191871 0,13617861 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,09191871 0,13606923 ! skin development GO:0043588 11 11 0,000 0,09191871 0,13596002 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,09191871 0,135851 ! microtubule-based transport GO:0010970 11 11 0,000 0,09191871 0,13574214 ! endothelial cell migration GO:0043542 11 11 0,000 0,09191871 0,13563346 ! peroxisomal transport GO:0043574 11 11 0,000 0,09191871 0,13552495 ! protein amino acid methylation GO:0006479 11 11 0,000 0,09191871 0,13541662 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,09191871 0,13530846 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,09191871 0,13520047 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,09191871 0,13509266 ! T cell proliferation GO:0042098 11 11 0,000 0,09191871 0,13498501 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,09191871 0,13487754 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,09191871 0,13477024 ! smooth muscle contraction GO:0006939 11 11 0,000 0,09191871 0,13466311 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,09191871 0,13455615 ! digestive system process GO:0022600 11 11 0,000 0,09191871 0,13444936 ! mitotic spindle organization GO:0007052 11 11 0,000 0,09191871 0,13434274 ! fucose metabolic process GO:0006004 11 11 0,000 0,09191871 0,13423628 ! membrane budding GO:0006900 11 11 0,000 0,09191871 0,13413 ! monoamine transport GO:0015844 11 11 0,000 0,09191871 0,13402389 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,09191871 0,13391794 ! body fluid secretion GO:0007589 11 11 0,000 0,09191871 0,13381216 ! intermediate filament-based process GO:0045103 11 11 0,000 0,09191871 0,13370654 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,09191871 0,1336011 GO:0060415|muscle tissue morphogenesis, ! interaction with host GO:0051701 11 11 0,000 0,09191871 0,13349582 ! membrane depolarization GO:0051899 11 11 0,000 0,09191871 0,1333907 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,09191871 0,13328575 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,09191871 0,13318097 ! oogenesis GO:0048477 11 11 0,000 0,09191871 0,13307635 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,09191871 0,13297189 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 0,000 0,09191871 0,1328676 GO:0006109|regulation of carbohydrate metabolic process, ! vitamin transport GO:0051180 11 11 0,000 0,09191871 0,13276347 ! muscle maintenance GO:0046716 12 11 0,000 0,09191871 0,13265951 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,09191871 0,13255571 ! hindbrain development GO:0030902 11 11 0,000 0,09191871 0,13245206 ! steroid catabolic process GO:0006706 11 11 0,000 0,09191871 0,13234859 ! endocrine process GO:0050886 11 11 0,000 0,09191871 0,13224527 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,09191871 0,13214211 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,09191871 0,13203912 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,09191871 0,13193629 ! protein localization in organelle GO:0033365 59 59 1,000 0,09332636 0,13385252 ! immune effector process GO:0002252 59 59 1,000 0,09332636 0,13374843 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 1,000 0,09602123 0,13750359 ! positive regulation of cellular protein metabolic process GO:0032270 61 61 1,000 0,09873846 0,14128492 ! translational initiation GO:0006413 12 12 0,000 0,09985071 0,1427656 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,09985071 0,14265493 ! initiation of viral infection GO:0019059 12 12 0,000 0,09985071 0,14254443 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,09985071 0,1424341 ! iron ion transport GO:0006826 13 12 0,000 0,09985071 0,14232394 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,09985071 0,14221396 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,09985071 0,14210414 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,09985071 0,14199449 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,09985071 0,14188501 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,09985071 0,1417757 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,09985071 0,14166656 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,09985071 0,14155758 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,09985071 0,14144878 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,09985071 0,14134014 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,09985071 0,14123166 ! actomyosin structure organization GO:0031032 12 12 0,000 0,09985071 0,14112336 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,09985071 0,14101522 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,09985071 0,14090724 ! retinoid metabolic process GO:0001523 12 12 0,000 0,09985071 0,14079943 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,09985071 0,14069179 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,09985071 0,14058431 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,09985071 0,14047699 GO:0006505|GPI anchor metabolic process, ! vacuolar transport GO:0007034 12 12 0,000 0,09985071 0,14036984 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,09985071 0,14026285 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,09985071 0,14015602 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,09985071 0,14004936 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,09985071 0,13994286 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,09985071 0,13983652 ! male gonad development GO:0008584 12 12 0,000 0,09985071 0,13973034 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,09985071 0,13962432 ! renal system process GO:0003014 12 12 0,000 0,09985071 0,13951847 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,09985071 0,13941277 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,09985071 0,13930724 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,09985071 0,13920186 ! pallium development GO:0021543 13 12 0,000 0,09985071 0,13909664 ! cell fate determination GO:0001709 12 12 0,000 0,09985071 0,13899159 ! positive regulation of multicellular organism growth GO:0040018 12 12 0,000 0,09985071 0,13888669 ! G1 phase GO:0051318 13 12 0,000 0,09985071 0,13878194 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,09985071 0,13867736 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,09985071 0,13857294 ! detection of light stimulus GO:0009583 13 12 0,000 0,09985071 0,13846867 ! synaptogenesis GO:0007416 12 12 0,000 0,09985071 0,13836456 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,09985071 0,1382606 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,09985071 0,1381568 ! heme biosynthetic process GO:0006783 12 12 0,000 0,09985071 0,13805316 ! spermatid differentiation GO:0048515 13 12 0,000 0,09985071 0,13794967 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,09985071 0,13784634 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,09985071 0,13774316 ! neural tube closure GO:0001843 13 12 0,000 0,09985071 0,13764013 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! negative regulation of translation GO:0017148 12 12 0,000 0,09985071 0,13753726 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,09985071 0,13743455 ! regulation of cellular component biogenesis GO:0044087 63 62 1,000 0,10147748 0,1395694 ! protein import GO:0017038 62 62 1,000 0,10147748 0,13946532 ! regulation of secretion GO:0051046 65 63 1,000 0,10423772 0,1431521 ! positive regulation of DNA replication GO:0045740 14 13 0,000 0,10771457 0,14781679 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,10771457 0,1477068 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,10771457 0,14759698 ! phenol metabolic process GO:0018958 13 13 0,000 0,10771457 0,14748733 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,10771457 0,14737784 ! gluconeogenesis GO:0006094 13 13 0,000 0,10771457 0,1472685 ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,10771457 0,14715934 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,10771457 0,14705033 ! regeneration GO:0031099 13 13 0,000 0,10771457 0,14694148 ! keratinization GO:0031424 13 13 0,000 0,10771457 0,1468328 ! post-embryonic development GO:0009791 14 13 0,000 0,10771457 0,14672427 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,10771457 0,14661591 ! patterning of blood vessels GO:0001569 13 13 0,000 0,10771457 0,14650771 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,10771457 0,14639966 ! regulation of innate immune response GO:0045088 13 13 0,000 0,10771457 0,14629178 ! autophagy GO:0006914 13 13 0,000 0,10771457 0,14618405 ! ureteric bud development GO:0001657 13 13 0,000 0,10771457 0,14607649 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,10771457 0,14596908 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,10771457 0,14586183 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,10771457 0,14575473 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,10771457 0,14564779 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,10771457 0,14554101 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,10771457 0,14543439 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,10771457 0,14532792 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,10771457 0,14522161 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,10771457 0,14511546 ! vasodilation GO:0042311 14 13 0,000 0,10771457 0,14500945 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,10771457 0,14490361 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,10771457 0,14479792 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,10771457 0,14469238 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,10771457 0,14458699 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,10771457 0,14448176 ! immunoglobulin production GO:0002377 13 13 0,000 0,10771457 0,14437669 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,10771457 0,14427176 ! regulation of cell-substrate adhesion GO:0010810 14 13 0,000 0,10771457 0,14416699 GO:0001952|regulation of cell-matrix adhesion, ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,10771457 0,14406237 ! response to cytokine stimulus GO:0034097 13 13 0,000 0,10771457 0,1439579 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,10771457 0,14385358 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,10771457 0,14374942 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,10771457 0,1436454 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,10771457 0,14354154 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,10771457 0,14343782 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,10771457 0,14333426 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,10771457 0,14323084 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,10771457 0,14312757 ! telomere organization GO:0032200 13 13 0,000 0,10771457 0,14302446 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,10771457 0,14292149 ! regulation of amine transport GO:0051952 13 13 0,000 0,10771457 0,14281866 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,10771457 0,14271599 ! regulation of hormone levels GO:0010817 66 65 1,000 0,10981962 0,14540055 ! DNA packaging GO:0006323 66 66 1,000 0,11264017 0,14902788 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,11264017 0,14892098 ! Ras protein signal transduction GO:0007265 69 67 1,000 0,11547975 0,15256571 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,11551086 0,1524975 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,11551086 0,15238834 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,11551086 0,15227933 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,11551086 0,15217048 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,11551086 0,15206179 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,11551086 0,15195325 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,11551086 0,15184487 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,11551086 0,15173664 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,11551086 0,15162857 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,11551086 0,15152065 ! vesicle docking GO:0048278 14 14 0,000 0,11551086 0,15141288 ! superoxide metabolic process GO:0006801 15 14 0,000 0,11551086 0,15130526 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,11551086 0,1511978 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,11551086 0,15109049 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,11551086 0,15098334 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,11551086 0,15087633 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,11551086 0,15076948 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,11551086 0,15066278 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! multicellular organismal response to stress GO:0033555 14 14 0,000 0,11551086 0,15055623 ! lysosome organization GO:0007040 14 14 0,000 0,11551086 0,15044983 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,11551086 0,15034358 ! primary neural tube formation GO:0014020 15 14 0,000 0,11551086 0,15023748 ! peptide cross-linking GO:0018149 14 14 0,000 0,11551086 0,15013153 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,11551086 0,15002573 ! response to organic cyclic substance GO:0014070 15 14 0,000 0,11551086 0,14992008 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,11551086 0,14981457 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,11551086 0,14970922 ! formation of primary germ layer GO:0001704 14 14 0,000 0,11551086 0,14960401 GO:0001707|mesoderm formation, ! collagen fibril organization GO:0030199 14 14 0,000 0,11551086 0,14949895 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,11551086 0,14939404 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,11551086 0,14928928 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,11551086 0,14918466 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,11551086 0,14908019 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,11551086 0,14897586 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,11551086 0,14887168 ! regulation of translation GO:0006417 69 69 1,000 0,12121381 0,15611255 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,12324015 0,15861145 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,12324015 0,15850077 ! positive regulation of ossification GO:0045778 15 15 0,000 0,12324015 0,15839024 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,12324015 0,15827986 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,12324015 0,15816964 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,12324015 0,15805957 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,12324015 0,15794965 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,12324015 0,15783989 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,12324015 0,15773028 ! ovarian follicle development GO:0001541 15 15 0,000 0,12324015 0,15762082 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,12324015 0,15751151 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,12324015 0,15740236 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,12324015 0,15729335 ! heme metabolic process GO:0042168 15 15 0,000 0,12324015 0,1571845 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,12324015 0,1570758 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,12324015 0,15696724 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,12324015 0,15685884 GO:0030500|regulation of bone mineralization, ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,12324015 0,15675059 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,12324015 0,15664248 ! phospholipid transport GO:0015914 15 15 0,000 0,12324015 0,15653453 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,12324015 0,15642672 ! glutathione metabolic process GO:0006749 16 15 0,000 0,12324015 0,15631906 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,12324015 0,15621155 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,12324015 0,15610419 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,12324015 0,15599698 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,12324015 0,15588991 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,12324015 0,15578299 ! growth GO:0040007 70 70 1,000 0,12410727 0,15677156 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,12701766 0,16033805 GO:0006874|cellular calcium ion homeostasis, ! regulation of cytokine production GO:0001817 72 72 1,000 0,12994448 0,16392039 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,13090302 0,1650166 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,13090302 0,1649038 ! learning GO:0007612 16 16 0,000 0,13090302 0,16479117 ! circadian rhythm GO:0007623 16 16 0,000 0,13090302 0,16467868 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,13090302 0,16456635 ! vacuole organization GO:0007033 16 16 0,000 0,13090302 0,16445417 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,13090302 0,16434214 ! vesicle targeting GO:0006903 17 16 0,000 0,13090302 0,16423027 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,13090302 0,16411855 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,13090302 0,16400698 ! iron ion homeostasis GO:0055072 16 16 0,000 0,13090302 0,16389556 ! positive regulation of cell development GO:0010720 16 16 0,000 0,13090302 0,16378429 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,13090302 0,16367318 ! lymphocyte proliferation GO:0046651 16 16 0,000 0,13090302 0,16356221 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,13090302 0,1634514 ! fatty acid transport GO:0015908 16 16 0,000 0,13090302 0,16334074 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,13090302 0,16323022 ! cofactor catabolic process GO:0051187 16 16 0,000 0,13090302 0,16311986 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,13090302 0,16300964 ! polyol metabolic process GO:0019751 16 16 0,000 0,13090302 0,16289957 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,13090302 0,16278965 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,13090302 0,16267988 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,13090302 0,16257026 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,13090302 0,16246079 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,13090302 0,16235146 ! regulation of coagulation GO:0050818 17 16 0,000 0,13090302 0,16224228 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,13850002 0,1715427 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,13850002 0,1714275 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,13850002 0,17131244 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,13850002 0,17119755 ! leukocyte adhesion GO:0007159 17 17 0,000 0,13850002 0,1710828 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,13850002 0,17096821 ! sensory perception of smell GO:0007608 17 17 0,000 0,13850002 0,17085378 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,13850002 0,17073949 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,13850002 0,17062536 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,13850002 0,17051138 ! development of primary male sexual characteristics GO:0046546 17 17 0,000 0,13850002 0,17039756 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,13850002 0,17028388 ! neural crest cell development GO:0014032 19 17 0,000 0,13850002 0,17017036 GO:0014033|neural crest cell differentiation, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,13850002 0,17005699 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,13850002 0,16994377 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,13850002 0,1698307 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,13850002 0,16971778 ! adult locomotory behavior GO:0008344 17 17 0,000 0,13850002 0,16960501 ! embryonic organ development GO:0048568 17 17 0,000 0,13850002 0,16949239 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,13850002 0,16937992 ! liver development GO:0001889 17 17 0,000 0,13850002 0,1692676 ! gene silencing GO:0016458 17 17 0,000 0,13850002 0,16915543 ! positive regulation of multicellular organismal process GO:0051240 76 76 1,000 0,1418063 0,17307882 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,144808 0,17662551 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,14603171 0,1780003 ! regulation of cellular catabolic process GO:0031329 18 18 0,000 0,14603171 0,17788265 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,14603171 0,17776516 ! membrane docking GO:0022406 18 18 0,000 0,14603171 0,17764782 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,14603171 0,17753064 ! mononuclear cell proliferation GO:0032943 18 18 0,000 0,14603171 0,17741361 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 0,000 0,14603171 0,17729674 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,14603171 0,17718002 ! cholesterol homeostasis GO:0042632 18 18 0,000 0,14603171 0,17706345 GO:0055092|sterol homeostasis, ! striated muscle contraction GO:0006941 18 18 0,000 0,14603171 0,17694704 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,14603171 0,17683078 GO:0006639|acylglycerol metabolic process, ! ceramide metabolic process GO:0006672 18 18 0,000 0,14603171 0,17671467 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,14603171 0,17659872 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,14603171 0,17648292 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,14603171 0,17636727 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,14603171 0,17625177 ! BMP signaling pathway GO:0030509 18 18 0,000 0,14603171 0,17613642 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,14603171 0,17602122 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 0,000 0,14603171 0,17590617 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,14603171 0,17579128 ! metal ion homeostasis GO:0055065 78 78 1,000 0,14782327 0,17783178 ! regulation of immune response GO:0050776 78 78 1,000 0,14782327 0,17771578 ! nuclear transport GO:0051169 79 79 1,000 0,15085165 0,18123833 GO:0006913|nucleocytoplasmic transport, ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,15349865 0,18429838 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,15349865 0,18417839 GO:0006956|complement activation, ! feeding behavior GO:0007631 19 19 0,000 0,15349865 0,18405856 ! peroxisome organization GO:0007031 19 19 0,000 0,15349865 0,18393889 ! regulation of striated muscle tissue development GO:0016202 20 19 0,000 0,15349865 0,18381937 ! metanephros development GO:0001656 19 19 0,000 0,15349865 0,1837 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,15349865 0,1835808 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,15349865 0,18346174 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,15349865 0,18334284 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,15349865 0,1832241 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,15349865 0,18310551 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,15349865 0,18298707 ! eye morphogenesis GO:0048592 19 19 0,000 0,15349865 0,18286878 ! response to heat GO:0009408 19 19 0,000 0,15349865 0,18275065 ! vesicle localization GO:0051648 20 19 0,000 0,15349865 0,18263267 ! MAPKKK cascade GO:0000165 82 81 1,000 0,15694598 0,18661383 ! lymphocyte activation GO:0046649 82 81 1,000 0,15694598 0,18649352 ! lipid catabolic process GO:0016042 82 81 1,000 0,15694598 0,18637335 ! regulation of muscle development GO:0048634 21 20 0,000 0,16090137 0,19094734 ! organic ether metabolic process GO:0018904 20 20 0,000 0,16090137 0,19082447 GO:0006662|glycerol ether metabolic process, ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,16090137 0,19070175 ! neural tube development GO:0021915 21 20 0,000 0,16090137 0,19057919 ! protein targeting to membrane GO:0006612 22 20 0,000 0,16090137 0,19045679 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,16090137 0,19033455 ! chromatin remodeling GO:0006338 20 20 0,000 0,16090137 0,19021246 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,16090137 0,19009053 ! lipid oxidation GO:0034440 20 20 0,000 0,16090137 0,18996875 GO:0019395|fatty acid oxidation, ! female gamete generation GO:0007292 20 20 0,000 0,16090137 0,18984713 ! negative regulation of neuron apoptosis GO:0043524 21 20 0,000 0,16090137 0,18972567 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,16090137 0,18960436 ! RNA modification GO:0009451 20 20 0,000 0,16090137 0,18948321 ! single fertilization GO:0007338 21 20 0,000 0,16090137 0,18936221 ! mRNA catabolic process GO:0006402 21 21 0,000 0,16824042 0,19787307 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,16824042 0,19774688 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,16824042 0,19762084 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,16824042 0,19749497 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,16824042 0,19736926 ! ear morphogenesis GO:0042471 21 21 0,000 0,16824042 0,1972437 ! organic anion transport GO:0015711 21 21 0,000 0,16824042 0,19711831 ! cholesterol transport GO:0030301 21 21 0,000 0,16824042 0,19699308 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,16824042 0,196868 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,16824042 0,19674309 GO:0032313|regulation of Rab GTPase activity, ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,16824042 0,19661833 ! regulation of multicellular organism growth GO:0040014 21 21 0,000 0,16824042 0,19649373 ! RNA export from nucleus GO:0006405 22 22 0,000 0,17551635 0,20486171 ! positive regulation of DNA metabolic process GO:0051054 23 22 0,000 0,17551635 0,20473205 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,17551635 0,20460255 ! regulation of ion transport GO:0043269 22 22 0,000 0,17551635 0,20447322 ! odontogenesis GO:0042476 22 22 0,000 0,17551635 0,20434405 ! hormone-mediated signaling GO:0009755 22 22 0,000 0,17551635 0,20421505 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,17551635 0,2040862 ! ovulation cycle process GO:0022602 22 22 0,000 0,17551635 0,20395752 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,17551635 0,20382901 ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,17551635 0,20370065 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,17551635 0,20357246 ! detection of external stimulus GO:0009581 23 22 0,000 0,17551635 0,20344442 ! neuron migration GO:0001764 22 22 0,000 0,17551635 0,20331655 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,17551635 0,20318884 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,17551635 0,20306129 ! aerobic respiration GO:0009060 22 22 0,000 0,17551635 0,2029339 ! cytokine production GO:0001816 22 22 0,000 0,17551635 0,20280667 ! male gamete generation GO:0048232 90 88 1,000 0,17862567 0,20627011 GO:0007283|spermatogenesis, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,18176168 0,20976003 ! response to hydrogen peroxide GO:0042542 24 23 0,000 0,18272968 0,21074518 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,18272968 0,21061338 ! viral infectious cycle GO:0019058 23 23 0,000 0,18272968 0,21048175 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,18272968 0,21035028 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,18272968 0,21021898 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,18272968 0,21008784 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,18272968 0,20995686 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,18272968 0,20982604 ! positive regulation of growth GO:0045927 23 23 0,000 0,18272968 0,20969539 ! female gonad development GO:0008585 23 23 0,000 0,18272968 0,2095649 ! lipid homeostasis GO:0055088 23 23 0,000 0,18272968 0,20943458 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,18272968 0,20930441 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,18272968 0,20917441 ! regulation of Ras protein signal transduction GO:0046578 90 90 1,000 0,18490624 0,21153458 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,18805897 0,21500787 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,18988094 0,21695634 ! glucose homeostasis GO:0042593 24 24 0,000 0,18988094 0,21682192 GO:0033500|carbohydrate homeostasis, ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,18988094 0,21668767 ! ovulation cycle GO:0042698 24 24 0,000 0,18988094 0,21655358 ! fertilization GO:0009566 25 24 0,000 0,18988094 0,21641965 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,18988094 0,2162859 ! epithelial tube morphogenesis GO:0060562 25 24 0,000 0,18988094 0,2161523 ! fatty acid metabolic process GO:0006631 93 92 1,000 0,1912195 0,21754169 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 1,000 0,1912195 0,21740749 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,19697067 0,22380823 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,19697067 0,22367033 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,19697067 0,2235326 ! cellular component disassembly GO:0022411 26 25 0,000 0,19697067 0,22339504 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,19697067 0,22325765 ! development of primary female sexual characteristics GO:0046545 25 25 0,000 0,19697067 0,22312043 GO:0046660|female sex differentiation, ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,19697067 0,22298338 ! excretion GO:0007588 25 25 0,000 0,19697067 0,2228465 ! gastrulation GO:0007369 25 25 0,000 0,19697067 0,22270978 ! heart morphogenesis GO:0003007 25 25 0,000 0,19697067 0,22257323 ! regulation of endocytosis GO:0030100 25 25 0,000 0,19697067 0,22243685 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,19697067 0,22230064 ! epidermis development GO:0008544 94 94 1,000 0,19756248 0,2228321 ! glycolysis GO:0006096 26 26 0,000 0,20399937 0,22995159 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,20399937 0,22981103 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,20399937 0,22967064 ! cellular defense response GO:0006968 26 26 0,000 0,20399937 0,22953043 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,20399937 0,22939039 ! germ cell development GO:0007281 27 26 0,000 0,20399937 0,22925051 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,20399937 0,22911081 GO:0035150|regulation of tube size, ! pigment metabolic process GO:0042440 26 26 0,000 0,20399937 0,22897128 ! glycoprotein metabolic process GO:0009100 99 98 1,000 0,21032621 0,23592892 ! regulation of system process GO:0044057 98 98 1,000 0,21032621 0,23578541 ! chloride transport GO:0006821 27 27 0,000 0,21096757 0,23636063 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,21096757 0,23621703 ! learning or memory GO:0007611 28 27 0,000 0,21096757 0,23607361 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,21096757 0,23593036 ! peptide metabolic process GO:0006518 29 27 0,000 0,21096757 0,23578728 ! inner ear development GO:0048839 27 27 0,000 0,21096757 0,23564438 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,21096757 0,23550166 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,21096757 0,2353591 ! cell growth GO:0016049 27 27 0,000 0,21096757 0,23521672 ! anti-apoptosis GO:0006916 100 99 1,000 0,21353134 0,23793123 ! ectoderm development GO:0007398 99 99 1,000 0,21353134 0,23778747 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 1,000 0,21674148 0,24121651 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,21787578 0,24233256 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,21787578 0,2421864 GO:0007254|JNK cascade, ! regulation of muscle contraction GO:0006937 28 28 0,000 0,21787578 0,24204042 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,21787578 0,24189461 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,21787578 0,24174898 ! cartilage development GO:0051216 29 28 0,000 0,21787578 0,24160353 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,2247245 0,24904826 ! viral reproductive process GO:0022415 29 29 0,000 0,2247245 0,24889859 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,2247245 0,2487491 ! branching morphogenesis of a tube GO:0048754 29 29 0,000 0,2247245 0,24859979 ! antigen processing and presentation GO:0019882 29 29 0,000 0,2247245 0,24845066 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,2247245 0,24830171 ! tRNA processing GO:0008033 29 29 0,000 0,2247245 0,24815294 ! adult behavior GO:0030534 30 29 0,000 0,2247245 0,24800435 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,2247245 0,24785593 ! transition metal ion transport GO:0000041 31 30 0,000 0,23151424 0,25519184 ! RNA catabolic process GO:0006401 30 30 0,000 0,23151424 0,2550393 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,23151424 0,25488695 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,23151424 0,25473478 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,23151424 0,25458279 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,23151424 0,25443098 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,23151424 0,25427935 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,23151424 0,25412791 GO:0019724|B cell mediated immunity, ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,23151424 0,25397664 ! vesicle organization GO:0016050 30 30 0,000 0,23151424 0,25382555 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,23151424 0,25367465 ! regulation of translational initiation GO:0006446 31 31 0,000 0,23824551 0,26089511 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,23824551 0,26074018 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,23824551 0,26058544 ! ion transmembrane transport GO:0034220 31 31 0,000 0,23824551 0,26043088 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,23824551 0,26027651 ! digestion GO:0007586 31 31 0,000 0,23824551 0,26012232 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,23824551 0,25996831 ! regulation of heart contraction GO:0008016 31 31 0,000 0,23824551 0,25981448 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,23824551 0,25966083 ! camera-type eye development GO:0043010 31 31 0,000 0,23824551 0,25950737 ! extracellular matrix organization GO:0030198 31 31 0,000 0,23824551 0,25935409 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,23824551 0,25920099 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,23824551 0,25904806 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,23824551 0,25889532 ! cell redox homeostasis GO:0045454 32 32 0,000 0,24491878 0,26599017 ! glucose catabolic process GO:0006007 32 32 0,000 0,24491878 0,26583352 ! lipid modification GO:0030258 32 32 0,000 0,24491878 0,26567706 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,24491878 0,26552077 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,24491878 0,26536468 ! morphogenesis of a branching structure GO:0001763 32 32 0,000 0,24491878 0,26520876 ! nuclear export GO:0051168 32 32 0,000 0,24491878 0,26505303 ! kidney development GO:0001822 32 32 0,000 0,24491878 0,26489749 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,25153456 0,27189337 ! amino acid transport GO:0006865 33 33 0,000 0,25153456 0,271734 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,25153456 0,27157481 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,25153456 0,27141581 ! regulation of actin filament length GO:0030832 34 34 0,000 0,25809334 0,27833003 ! response to metal ion GO:0010038 34 34 0,000 0,25809334 0,27816727 ! ear development GO:0043583 34 34 0,000 0,25809334 0,27800469 ! muscle cell differentiation GO:0042692 35 34 0,000 0,25809334 0,2778423 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,25809334 0,27768011 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,25809334 0,2775181 ! secondary metabolic process GO:0019748 34 34 0,000 0,25809334 0,27735628 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,25809334 0,27719465 ! detection of stimulus GO:0051606 36 34 0,000 0,25809334 0,27703321 ! regulation of cellular component size GO:0032535 35 35 0,000 0,26459559 0,2838473 ! inorganic anion transport GO:0015698 35 35 0,000 0,26459559 0,28368218 ! hydrogen transport GO:0006818 36 36 0,000 0,27104179 0,29042443 GO:0015992|proton transport, ! response to inorganic substance GO:0010035 36 36 0,000 0,27104179 0,29025568 ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,27104179 0,29008712 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 0,000 0,27104179 0,28991876 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,27104179 0,28975059 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,27104179 0,28958262 ! activation of immune response GO:0002253 36 36 0,000 0,27104179 0,28941485 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,27743243 0,29606715 ! eye development GO:0001654 37 37 0,000 0,27743243 0,29589581 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,27743243 0,29572467 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,27743243 0,29555373 ! neurotransmitter transport GO:0006836 40 38 0,000 0,28376796 0,30212845 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,28376796 0,30195401 ! hexose catabolic process GO:0019320 38 38 0,000 0,28376796 0,30177977 ! RNA elongation GO:0006354 38 38 0,000 0,28376796 0,30160574 ! activation of MAPK activity GO:0000187 39 39 0,000 0,29004886 0,30810377 ! response to unfolded protein GO:0006986 39 39 0,000 0,29004886 0,30792629 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,29004886 0,30774902 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,29004886 0,30757195 ! amine catabolic process GO:0009310 42 41 0,000 0,30244861 0,3205364 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,30244861 0,32035218 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,30244861 0,32016817 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,30244861 0,31998438 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,30244861 0,3198008 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,30856838 0,32608459 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,30856838 0,32589772 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,30856838 0,32571107 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! response to protein stimulus GO:0051789 42 42 0,000 0,30856838 0,32552463 ! forebrain development GO:0030900 43 42 0,000 0,30856838 0,3253384 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,30856838 0,32515238 ! alcohol catabolic process GO:0046164 43 43 0,000 0,31463534 0,33135596 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 0,000 0,32064995 0,33749735 ! mRNA transport GO:0051028 44 44 0,000 0,32064995 0,33730471 ! vitamin metabolic process GO:0006766 44 44 0,000 0,32064995 0,3371123 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,32661265 0,34318535 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 0,000 0,32661265 0,34298981 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,32661265 0,34279448 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,33252388 0,34879995 ! tube morphogenesis GO:0035239 47 46 0,000 0,33252388 0,34860154 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 0,000 0,33252388 0,34840336 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,33252388 0,3482054 ! positive regulation of ligase activity GO:0051351 47 46 0,000 0,33252388 0,34800767 ! amine transport GO:0015837 47 47 0,000 0,33838407 0,35393975 ! rhythmic process GO:0048511 47 47 0,000 0,33838407 0,35373899 ! calcium ion transport GO:0006816 48 48 0,000 0,34419366 0,35960823 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 0,000 0,34419366 0,35940449 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,34419366 0,35920098 ! DNA recombination GO:0006310 48 48 0,000 0,34419366 0,35899769 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,34995309 0,36479838 ! divalent metal ion transport GO:0070838 49 49 0,000 0,34995309 0,36459217 ! regulation of ligase activity GO:0051340 50 49 0,000 0,34995309 0,36438618 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,34995309 0,36418043 ! chromatin assembly GO:0031497 50 50 0,000 0,35566277 0,36991336 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,35566277 0,36970473 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,35566277 0,36949632 ! transcription initiation GO:0006352 50 50 0,000 0,35566277 0,36928816 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,36132312 0,37495412 ! positive regulation of immune response GO:0050778 51 51 0,000 0,36132312 0,37474311 ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,36132312 0,37453235 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,36132312 0,37432182 ! RNA localization GO:0006403 52 52 0,000 0,36693458 0,37992159 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,36693458 0,37970827 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,36693458 0,37949519 ! sodium ion transport GO:0006814 53 53 0,000 0,37249754 0,38503251 ! tRNA metabolic process GO:0006399 53 53 0,000 0,37249754 0,38481669 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,37249754 0,3846011 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,37249754 0,38438576 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,37249754 0,38417066 ! protein amino acid dephosphorylation GO:0006470 55 54 0,000 0,37801243 0,38964033 ! hormone metabolic process GO:0042445 55 54 0,000 0,37801243 0,38942253 ! sulfur metabolic process GO:0006790 55 54 0,000 0,37801243 0,38920498 ! nucleosome organization GO:0034728 55 55 0,000 0,38347965 0,39461362 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,38347965 0,39439341 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,38889961 0,39974455 ! ATP metabolic process GO:0046034 57 57 0,000 0,39427271 0,40504158 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,39427271 0,40481593 ! innate immune response GO:0045087 58 58 0,000 0,39959934 0,41005657 ! dephosphorylation GO:0016311 60 59 0,000 0,40487991 0,41524412 ! carboxylic acid transport GO:0046942 59 59 0,000 0,40487991 0,41501317 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 0,000 0,40487991 0,41478248 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,40487991 0,41455204 ! potassium ion transport GO:0006813 60 60 0,000 0,41011481 0,41967884 ! protein polymerization GO:0051258 65 60 0,000 0,41011481 0,41944594 ! cellular respiration GO:0045333 62 61 0,000 0,41530441 0,42451804 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,41530441 0,42428272 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,41530441 0,42404766 GO:0016054|organic acid catabolic process, ! lipid transport GO:0006869 62 62 0,000 0,42044912 0,42906297 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,42044912 0,42882552 ! morphogenesis of an epithelium GO:0002009 63 62 0,000 0,42044912 0,42858834 GO:0060429|epithelium development, ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,42044912 0,42835142 ! glucose metabolic process GO:0006006 63 63 0,000 0,4255493 0,43330793 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,4255493 0,43306867 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,4255493 0,43282967 ! glycerolipid metabolic process GO:0046486 65 64 0,000 0,43060534 0,43773064 ! regulation of cytoskeleton organization GO:0051493 66 64 0,000 0,43060534 0,43748933 ! anion transport GO:0006820 65 65 0,000 0,43561762 0,44233789 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,4405865 0,44713707 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,4405865 0,44689099 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,44551236 0,45163877 ! muscle contraction GO:0006936 67 67 0,000 0,44551236 0,45139048 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,45039557 0,45608738 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,45039557 0,45583692 ! sensory perception of sound GO:0007605 71 69 0,000 0,45523647 0,46048344 GO:0050954|sensory perception of mechanical stimulus, ! translational elongation GO:0006414 71 71 0,000 0,46479284 0,46989205 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,46479284 0,46963444 ! negative regulation of signal transduction GO:0009968 71 71 0,000 0,46479284 0,4693771 ! muscle system process GO:0003012 72 72 0,000 0,46950902 0,47388013 ! sensory organ development GO:0007423 72 72 0,000 0,46950902 0,47362076 ! electron transport chain GO:0022900 75 74 0,000 0,4788191 0,48274814 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,4788191 0,4824842 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,4834137 0,48684779 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,4834137 0,4865819 ! negative regulation of cell communication GO:0010648 76 76 0,000 0,48796847 0,49089841 ! microtubule-based movement GO:0007018 82 78 0,000 0,49695985 0,49967103 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,50579592 0,50827802 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,51876459 0,52102624 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,52301266 0,52500672 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,53139848 0,53313413 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 0,000 0,53139848 0,53284407 ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,53963927 0,54081304 ! brain development GO:0007420 91 90 0,000 0,54773752 0,54863057 ! visual perception GO:0007601 93 92 0,000 0,55569565 0,55629934 GO:0050953|sensory perception of light stimulus, ! tissue morphogenesis GO:0048729 94 93 0,000 0,55962291 0,55992673 ! cofactor metabolic process GO:0051186 95 94 0,000 0,56351604 0,56351604