pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6932-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of positive chemotaxis GO:0050930 14 8 3,000 2,394E-07 5,507E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 2,394E-07 2,754E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 3,000 2,394E-07 1,836E-04 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 7,957E-07 4,575E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 9,988E-07 4,595E-04 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 3,000 1,108E-06 4,249E-04 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 1,108E-06 3,642E-04 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 1,241E-06 3,567E-04 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of cellular catabolic process GO:0031331 22 12 3,000 1,653E-06 4,223E-04 ! regulation of angiogenesis GO:0045765 94 49 5,000 2,108E-06 4,849E-04 ! positive regulation of catabolic process GO:0009896 40 28 4,000 2,252E-06 4,71E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 2,373E-06 4,548E-04 ! regulation of monooxygenase activity GO:0032768 26 13 3,000 2,373E-06 4,198E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 4,553E-06 7,48E-04 ! positive regulation of viral genome replication GO:0045070 8 5 2,000 4,553E-06 6,981E-04 ! cranial nerve morphogenesis GO:0021602 6 5 2,000 4,553E-06 6,545E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 5,000 5,199E-06 7,034E-04 ! negative regulation of kinase activity GO:0033673 100 58 5,000 5,762E-06 7,362E-04 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 6,143E-06 7,436E-04 ! regulation of homeostatic process GO:0032844 105 60 5,000 7,037E-06 8,092E-04 ! regulation of intracellular protein transport GO:0033157 59 35 4,000 7,122E-06 7,8E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 7,709E-06 8,06E-04 ! urogenital system development GO:0001655 101 61 5,000 7,755E-06 7,755E-04 ! negative regulation of transferase activity GO:0051348 105 61 5,000 7,755E-06 7,432E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 9,054E-06 8,33E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 2,000 9,054E-06 8,01E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 9,054E-06 7,713E-04 ! sex determination GO:0007530 29 19 3,000 1,24E-05 1,019E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 1,399E-05 1,11E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 1,541E-05 1,182E-03 ! positive regulation of locomotion GO:0040017 35 20 3,000 1,541E-05 1,143E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,575E-05 1,132E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,575E-05 1,098E-03 ! positive regulation of monooxygenase activity GO:0032770 11 7 2,000 1,575E-05 1,066E-03 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 1,729E-05 1,136E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 1,787E-05 1,141E-03 ! regulation of chemotaxis GO:0050920 36 21 3,000 1,892E-05 1,176E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 2,009E-05 1,216E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 5,000 2,035E-05 1,2E-03 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of behavior GO:0050795 38 22 3,000 2,299E-05 1,322E-03 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 2,382E-05 1,336E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 2,506E-05 1,373E-03 ! positive regulation of cell cycle GO:0045787 77 45 4,000 2,518E-05 1,347E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 2,518E-05 1,316E-03 ! regulation of cellular catabolic process GO:0031329 36 24 3,000 3,3E-05 1,686E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 3,000 3,3E-05 1,65E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 3,000 3,3E-05 1,615E-03 ! regulation of developmental growth GO:0048638 13 9 2,000 3,738E-05 1,791E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 2,000 3,738E-05 1,755E-03 ! regulation of glycolysis GO:0006110 15 9 2,000 3,738E-05 1,72E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 3,738E-05 1,686E-03 ! regulation of intracellular transport GO:0032386 78 49 4,000 3,834E-05 1,696E-03 ! negative regulation of protein modification process GO:0031400 50 26 3,000 4,586E-05 1,99E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 4,664E-05 1,987E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 4,664E-05 1,951E-03 ! regulation of bone resorption GO:0045124 24 10 2,000 5,31E-05 2,181E-03 ! cranial nerve development GO:0021545 12 10 2,000 5,31E-05 2,143E-03 ! positive regulation of viral reproduction GO:0048524 15 10 2,000 5,31E-05 2,106E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 5,31E-05 2,07E-03 GO:0043470|regulation of carbohydrate catabolic process, ! negative regulation of MAP kinase activity GO:0043407 54 28 3,000 6,206E-05 2,379E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 7,259E-05 2,737E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 7,259E-05 2,693E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 7,259E-05 2,65E-03 GO:0010829|negative regulation of glucose transport, ! positive regulation of cell motion GO:0051272 99 56 4,000 7,352E-05 2,642E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 8,009E-05 2,834E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 8,686E-05 3,027E-03 ! metanephros development GO:0001656 58 31 3,000 9,366E-05 3,215E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 2,000 9,624E-05 3,255E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! autonomic nervous system development GO:0048483 23 12 2,000 9,624E-05 3,208E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 2,000 9,624E-05 3,162E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 5,000 1,229E-04 3,982E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 1,295E-04 4,138E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 1,396E-04 4,399E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 1,574E-04 4,893E-03 ! learning or memory GO:0007611 123 68 4,000 1,862E-04 5,711E-03 ! negative regulation of cell cycle process GO:0010948 24 15 2,000 1,957E-04 5,922E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 1,957E-04 5,845E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 1,957E-04 5,77E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,957E-04 5,697E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,957E-04 5,625E-03 ! positive regulation of oxidoreductase activity GO:0051353 21 15 2,000 1,957E-04 5,556E-03 ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 1,957E-04 5,488E-03 ! regulation of catabolic process GO:0009894 106 70 4,000 2,135E-04 5,917E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 2,333E-04 6,389E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 2,395E-04 6,479E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,395E-04 6,404E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 2,395E-04 6,33E-03 ! nerve development GO:0021675 18 16 2,000 2,395E-04 6,258E-03 ! response to hypoxia GO:0001666 132 72 4,000 2,438E-04 6,301E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 2,577E-04 6,586E-03 ! negative regulation of transport GO:0051051 116 73 4,000 2,601E-04 6,575E-03 ! response to oxygen levels GO:0070482 137 74 4,000 2,772E-04 6,931E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 2,891E-04 7,15E-03 ! regulation of viral genome replication GO:0045069 24 17 2,000 2,891E-04 7,074E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,891E-04 7E-03 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 2,891E-04 6,927E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,891E-04 6,855E-03 ! regulation of cell morphogenesis GO:0022604 140 76 4,000 3,14E-04 7,371E-03 ! regulation of protein transport GO:0051223 114 76 4,000 3,14E-04 7,296E-03 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 148 77 4,000 3,338E-04 7,677E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 3,418E-04 7,783E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 3,45E-04 7,779E-03 ! response to retinoic acid GO:0032526 25 18 2,000 3,45E-04 7,703E-03 ! peptide cross-linking GO:0018149 31 18 2,000 3,45E-04 7,629E-03 ! regulation of glucose import GO:0046324 21 18 2,000 3,45E-04 7,556E-03 GO:0010827|regulation of glucose transport, ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 2,000 3,45E-04 7,485E-03 ! positive regulation of protein modification process GO:0031401 107 78 4,000 3,544E-04 7,619E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 3,737E-04 7,958E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 3,737E-04 7,885E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 4,073E-04 8,517E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 4,073E-04 8,44E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 4,073E-04 8,365E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 4,073E-04 8,291E-03 ! response to vitamin A GO:0033189 26 19 2,000 4,073E-04 8,218E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 4,073E-04 8,146E-03 ! regulation of endothelial cell migration GO:0010594 40 19 2,000 4,073E-04 8,076E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 4,073E-04 8,007E-03 ! response to UV GO:0009411 75 46 3,000 4,438E-04 8,651E-03 ! ossification GO:0001503 134 82 4,000 4,469E-04 8,637E-03 GO:0060348|bone development, ! response to vitamin GO:0033273 29 20 2,000 4,765E-04 9,133E-03 ! spinal cord development GO:0021510 31 20 2,000 4,765E-04 9,057E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 4,765E-04 8,983E-03 ! camera-type eye morphogenesis GO:0048593 34 20 2,000 4,765E-04 8,91E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 4,822E-04 8,945E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 5,273E-04 9,703E-03 ! anterior/posterior pattern formation GO:0009952 124 85 4,000 5,273E-04 9,626E-03 ! regulation of protein localization GO:0032880 132 85 4,000 5,273E-04 9,55E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 5,527E-04 9,932E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 5,564E-04 9,921E-03 ! cartilage development GO:0051216 70 49 3,000 5,66E-04 0,01001373 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,916E-04 0,01038724 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 5,916E-04 0,01030855 ! forebrain regionalization GO:0021871 6 5 1,000 5,916E-04 0,01023104 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 5,916E-04 0,01015469 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,916E-04 0,01007947 ! embryonic hemopoiesis GO:0035162 10 5 1,000 5,916E-04 0,01000536 ! anagen GO:0042640 6 5 1,000 5,916E-04 9,932E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 5,916E-04 9,86E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! regulation of retroviral genome replication GO:0045091 6 5 1,000 5,916E-04 9,789E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,916E-04 9,719E-03 ! microvillus organization GO:0032528 7 5 1,000 5,916E-04 9,651E-03 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 1,000 5,916E-04 9,583E-03 ! response to food GO:0032094 5 5 1,000 5,916E-04 9,516E-03 ! paraxial mesoderm development GO:0048339 9 5 1,000 5,916E-04 9,45E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 5,916E-04 9,384E-03 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 1,000 5,916E-04 9,32E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 5,916E-04 9,257E-03 GO:0045686|negative regulation of glial cell differentiation, ! forebrain morphogenesis GO:0048853 13 5 1,000 5,916E-04 9,194E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 5,916E-04 9,132E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 5,916E-04 9,072E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 5,916E-04 9,011E-03 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 5,916E-04 8,952E-03 GO:0007439|ectodermal gut development, ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 5,916E-04 8,894E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 5,916E-04 8,836E-03 GO:0022011|myelination in the peripheral nervous system, ! positive regulation of growth GO:0045927 67 50 3,000 6,115E-04 9,074E-03 ! interphase GO:0051325 159 88 4,000 6,182E-04 9,115E-03 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 6,364E-04 9,323E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 6,364E-04 9,264E-03 ! vasculogenesis GO:0001570 33 22 2,000 6,364E-04 9,206E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 6,364E-04 9,148E-03 GO:0010810|regulation of cell-substrate adhesion, ! reproductive developmental process GO:0003006 127 89 4,000 6,51E-04 9,299E-03 ! regulation of neurogenesis GO:0050767 153 89 4,000 6,51E-04 9,242E-03 ! negative regulation of cell motion GO:0051271 104 51 3,000 6,596E-04 9,307E-03 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 7,277E-04 0,01020543 ! myelination GO:0042552 35 23 2,000 7,277E-04 0,01014358 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 7,277E-04 0,01008247 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 7,277E-04 0,0100221 ! regulation of viral reproduction GO:0050792 32 23 2,000 7,277E-04 9,962E-03 ! regulation of bone remodeling GO:0046850 90 53 3,000 7,637E-04 0,01039338 ! skeletal system morphogenesis GO:0048705 78 53 3,000 7,637E-04 0,01033224 ! kidney development GO:0001822 90 53 3,000 7,637E-04 0,01027182 ! regulation of mitosis GO:0007088 84 54 3,000 8,199E-04 0,01096313 GO:0051783|regulation of nuclear division, ! regulation of tissue remodeling GO:0034103 91 54 3,000 8,199E-04 0,01089976 ! negative regulation of cell development GO:0010721 56 24 2,000 8,269E-04 0,01093074 GO:0050768|negative regulation of neurogenesis, ! mesoderm development GO:0007498 76 55 3,000 8,789E-04 0,01155085 ! prostate gland development GO:0030850 9 6 1,000 8,829E-04 0,01153796 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 8,829E-04 0,01147277 ! neuron adhesion GO:0007158 9 6 1,000 8,829E-04 0,01140832 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 8,829E-04 0,01134458 ! mRNA stabilization GO:0048255 15 6 1,000 8,829E-04 0,01128156 GO:0043489|RNA stabilization, ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 8,829E-04 0,01121923 ! activation of MAPKKK activity GO:0000185 10 6 1,000 8,829E-04 0,01115759 ! ER overload response GO:0006983 7 6 1,000 8,829E-04 0,01109662 ! male sex determination GO:0030238 9 6 1,000 8,829E-04 0,01103631 ! spindle checkpoint GO:0031577 14 6 1,000 8,829E-04 0,01097665 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 8,829E-04 0,01091764 ! astrocyte development GO:0014002 14 6 1,000 8,829E-04 0,01085925 ! DNA topological change GO:0006265 8 6 1,000 8,829E-04 0,01080149 ! gas homeostasis GO:0033483 11 6 1,000 8,829E-04 0,01074434 ! hair follicle maturation GO:0048820 7 6 1,000 8,829E-04 0,01068779 ! Schwann cell development GO:0014044 14 6 1,000 8,829E-04 0,01063184 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 8,829E-04 0,01057646 ! axonal fasciculation GO:0007413 9 6 1,000 8,829E-04 0,01052166 ! negative regulation of axon extension GO:0030517 13 6 1,000 8,829E-04 0,01046743 ! response to light stimulus GO:0009416 153 96 4,000 9,18E-04 0,01082728 ! iron ion homeostasis GO:0055072 39 25 2,000 9,344E-04 0,01096459 ! regulation of chromosome organization GO:0033044 35 25 2,000 9,344E-04 0,01090893 ! positive regulation of nuclear division GO:0051785 39 25 2,000 9,344E-04 0,01085383 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 9,344E-04 0,01079929 ! camera-type eye development GO:0043010 88 57 3,000 1,006E-03 0,01156646 ! lung development GO:0030324 94 59 3,000 1,145E-03 0,01310253 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,175E-03 0,01337711 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,23E-03 0,01393329 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,23E-03 0,01386499 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,23E-03 0,01379736 ! microtubule bundle formation GO:0001578 8 7 1,000 1,23E-03 0,01373038 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,23E-03 0,01366405 ! spinal cord patterning GO:0021511 7 7 1,000 1,23E-03 0,01359836 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,23E-03 0,01353329 ! adrenal gland development GO:0030325 17 7 1,000 1,23E-03 0,01346885 ! regulation of defense response to virus by virus GO:0050690 16 7 1,000 1,23E-03 0,01340502 ! protein heterooligomerization GO:0051291 10 7 1,000 1,23E-03 0,01334179 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,23E-03 0,01327915 ! regulation of synaptogenesis GO:0051963 10 7 1,000 1,23E-03 0,0132171 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 1,308E-03 0,01399679 ! ensheathment of neurons GO:0007272 43 28 2,000 1,308E-03 0,01393199 GO:0008366|axon ensheathment, ! placenta development GO:0001890 37 28 2,000 1,308E-03 0,01386779 ! respiratory tube development GO:0030323 99 62 3,000 1,378E-03 0,01454377 ! regulation of axonogenesis GO:0050770 51 29 2,000 1,451E-03 0,01523994 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,451E-03 0,01517067 ! telencephalon development GO:0021537 52 29 2,000 1,451E-03 0,01510202 ! eye morphogenesis GO:0048592 51 29 2,000 1,451E-03 0,01503399 ! respiratory system development GO:0060541 100 64 3,000 1,551E-03 0,01600107 ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 1,603E-03 0,01646166 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,631E-03 0,01667583 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,631E-03 0,01660205 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,631E-03 0,01652891 ! succinate metabolic process GO:0006105 14 8 1,000 1,631E-03 0,01645641 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,631E-03 0,01638455 ! smoothened signaling pathway GO:0007224 8 8 1,000 1,631E-03 0,01631332 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,631E-03 0,01624269 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,631E-03 0,01617268 ! astrocyte differentiation GO:0048708 16 8 1,000 1,631E-03 0,01610327 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,631E-03 0,01603446 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,631E-03 0,01596622 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,631E-03 0,01589857 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,631E-03 0,01583149 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 1,000 1,631E-03 0,01576497 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,631E-03 0,01569901 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 1,631E-03 0,01563359 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,631E-03 0,01556872 ! regulation of embryonic development GO:0045995 16 8 1,000 1,631E-03 0,01550439 ! reproductive structure development GO:0048608 90 65 3,000 1,643E-03 0,0155537 ! mammary gland development GO:0030879 57 31 2,000 1,765E-03 0,01663693 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,765E-03 0,01656902 GO:0060326|cell chemotaxis, ! regulation of neuron differentiation GO:0045664 107 67 3,000 1,838E-03 0,01718692 ! peripheral nervous system development GO:0007422 53 32 2,000 1,937E-03 0,01803252 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 2,087E-03 0,01935288 ! artery development GO:0060840 19 9 1,000 2,087E-03 0,01927516 GO:0048844|artery morphogenesis, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 2,087E-03 0,01919806 ! lung alveolus development GO:0048286 17 9 1,000 2,087E-03 0,01912157 ! ventral spinal cord development GO:0021517 11 9 1,000 2,087E-03 0,0190457 ! phosphagen metabolic process GO:0006599 12 9 1,000 2,087E-03 0,01897042 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 14 9 1,000 2,087E-03 0,01889573 ! DNA ligation GO:0006266 14 9 1,000 2,087E-03 0,01882163 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,087E-03 0,01874811 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,087E-03 0,01867516 ! embryonic placenta development GO:0001892 12 9 1,000 2,087E-03 0,01860277 ! regulation of synapse organization GO:0050807 12 9 1,000 2,087E-03 0,01853095 ! localization within membrane GO:0051668 15 9 1,000 2,087E-03 0,01845967 ! carbohydrate homeostasis GO:0033500 39 33 2,000 2,118E-03 0,01866573 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 2,000 2,118E-03 0,01859448 ! eye development GO:0001654 111 70 3,000 2,16E-03 0,01888909 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 2,31E-03 0,02012514 ! regulation of neuron projection development GO:0010975 63 34 2,000 2,31E-03 0,0200492 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 2,31E-03 0,01997383 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 2,31E-03 0,01989902 ! embryonic organ development GO:0048568 45 34 2,000 2,31E-03 0,01982477 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 2,000 2,31E-03 0,01975107 ! negative regulation of organelle organization GO:0010639 115 72 3,000 2,395E-03 0,02039967 ! regulation of action potential in neuron GO:0019228 54 35 2,000 2,512E-03 0,02132224 ! glycogen metabolic process GO:0005977 48 35 2,000 2,512E-03 0,02124385 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 2,512E-03 0,02116603 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! neuron fate specification GO:0048665 11 10 1,000 2,595E-03 0,02178417 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,595E-03 0,02170496 ! blood vessel remodeling GO:0001974 21 10 1,000 2,595E-03 0,02162631 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,595E-03 0,02154824 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,595E-03 0,02147073 ! glucan biosynthetic process GO:0009250 13 10 1,000 2,595E-03 0,02139377 GO:0005978|glycogen biosynthetic process, ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 2,595E-03 0,02131737 ! negative regulation of axonogenesis GO:0050771 23 10 1,000 2,595E-03 0,0212415 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,595E-03 0,02116618 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,595E-03 0,02109139 ! embryonic gut development GO:0048566 11 10 1,000 2,595E-03 0,02101712 ! regulation of synapse structure and activity GO:0050803 13 10 1,000 2,595E-03 0,02094338 ! tissue remodeling GO:0048771 62 36 2,000 2,725E-03 0,02191627 ! glucan metabolic process GO:0044042 49 36 2,000 2,725E-03 0,02183991 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 67 37 2,000 2,949E-03 0,02355082 ! sex differentiation GO:0007548 105 77 3,000 3,057E-03 0,02433277 ! virus-host interaction GO:0019048 17 11 1,000 3,156E-03 0,02502818 ! detection of mechanical stimulus GO:0050982 15 11 1,000 3,156E-03 0,02494218 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,156E-03 0,02485676 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 3,156E-03 0,02477192 ! T cell homeostasis GO:0043029 20 11 1,000 3,156E-03 0,02468766 ! regulation of leukocyte migration GO:0002685 24 11 1,000 3,156E-03 0,02460398 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,156E-03 0,02452085 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 3,156E-03 0,02443829 GO:0042130|negative regulation of T cell proliferation, ! gliogenesis GO:0042063 71 38 2,000 3,184E-03 0,02457206 ! regulation of T cell proliferation GO:0042129 58 38 2,000 3,184E-03 0,02448988 ! pigmentation GO:0043473 74 38 2,000 3,184E-03 0,02440825 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 3,43E-03 0,02620584 ! male sex differentiation GO:0046661 53 39 2,000 3,43E-03 0,02611907 ! developmental growth GO:0048589 62 39 2,000 3,43E-03 0,02603287 ! regulation of cell cycle process GO:0010564 122 81 3,000 3,67E-03 0,02776903 ! T cell differentiation GO:0030217 65 40 2,000 3,687E-03 0,02780153 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 3,687E-03 0,02771067 ! positive regulation of protein transport GO:0051222 55 40 2,000 3,687E-03 0,02762041 ! negative regulation of cell projection organization GO:0031345 26 12 1,000 3,768E-03 0,02813486 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 3,768E-03 0,02804381 ! cytokine biosynthetic process GO:0042089 16 12 1,000 3,768E-03 0,02795334 ! heart looping GO:0001947 15 12 1,000 3,768E-03 0,02786346 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 1,000 3,768E-03 0,02777416 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 3,768E-03 0,02768542 ! histone acetylation GO:0016573 23 12 1,000 3,768E-03 0,02759725 ! peptidyl-lysine modification GO:0018205 18 12 1,000 3,768E-03 0,02750964 ! regulation of mRNA stability GO:0043488 27 12 1,000 3,768E-03 0,02742258 ! epithelial cell differentiation GO:0030855 55 41 2,000 3,955E-03 0,02869829 ! energy reserve metabolic process GO:0006112 59 41 2,000 3,955E-03 0,02860804 ! regulation of cell adhesion GO:0030155 159 83 3,000 4,006E-03 0,02888287 ! regulation of defense response GO:0031347 117 84 3,000 4,181E-03 0,03005278 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 4,181E-03 0,02995916 ! embryonic skeletal system development GO:0048706 56 42 2,000 4,236E-03 0,0302546 ! regulation of cell shape GO:0008360 78 42 2,000 4,236E-03 0,03016093 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 4,43E-03 0,03144773 ! regulation of chemokine production GO:0032642 17 13 1,000 4,43E-03 0,03135097 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 4,43E-03 0,0312548 ! cytokine metabolic process GO:0042107 17 13 1,000 4,43E-03 0,03115922 ! bone mineralization GO:0030282 15 13 1,000 4,43E-03 0,03106423 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 4,43E-03 0,03096981 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,43E-03 0,03087596 ! regulation of RNA stability GO:0043487 28 13 1,000 4,43E-03 0,03078268 ! regulation of axon extension GO:0030516 23 13 1,000 4,43E-03 0,03068996 ! lymphocyte homeostasis GO:0002260 24 13 1,000 4,43E-03 0,0305978 ! positive regulation of binding GO:0051099 59 43 2,000 4,528E-03 0,03117867 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 4,528E-03 0,03108559 ! leukocyte migration GO:0050900 60 43 2,000 4,528E-03 0,03099308 ! cell cycle arrest GO:0007050 150 86 3,000 4,547E-03 0,03103512 ! regulation of cell projection organization GO:0031344 83 44 2,000 4,832E-03 0,03287799 ! regulation of action potential GO:0001508 71 44 2,000 4,832E-03 0,03278101 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 4,832E-03 0,03268459 ! regulation of inflammatory response GO:0050727 60 44 2,000 4,832E-03 0,03258874 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 5,142E-03 0,03458157 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 5,142E-03 0,03448075 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,142E-03 0,03438051 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 5,142E-03 0,03428086 ! heterophilic cell adhesion GO:0007157 29 14 1,000 5,142E-03 0,03418178 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 5,142E-03 0,03408327 ! activation of MAPKK activity GO:0000186 21 14 1,000 5,142E-03 0,03398533 ! regulation of defense response to virus GO:0050688 24 14 1,000 5,142E-03 0,03388795 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 5,142E-03 0,03379113 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 5,142E-03 0,03369486 GO:0060675|ureteric bud morphogenesis, ! positive regulation of axonogenesis GO:0050772 19 14 1,000 5,142E-03 0,03359914 ! muscle maintenance GO:0046716 19 14 1,000 5,142E-03 0,03350395 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 5,142E-03 0,03340931 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,142E-03 0,0333152 ! positive regulation of defense response GO:0031349 59 45 2,000 5,148E-03 0,03325717 ! cell recognition GO:0008037 58 45 2,000 5,148E-03 0,03316401 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 5,816E-03 0,03736712 ! lipid phosphorylation GO:0046834 23 15 1,000 5,903E-03 0,03781945 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 1,000 5,903E-03 0,03771439 ! positive regulation of proteolysis GO:0045862 19 15 1,000 5,903E-03 0,03760992 ! cerebral cortex development GO:0021987 29 15 1,000 5,903E-03 0,03750603 ! neuron recognition GO:0008038 22 15 1,000 5,903E-03 0,03740271 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 5,903E-03 0,03729995 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,903E-03 0,03719776 ! biomineral formation GO:0031214 18 15 1,000 5,903E-03 0,03709613 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 5,903E-03 0,03699505 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 5,903E-03 0,03689452 ! regulation of muscle contraction GO:0006937 69 48 2,000 6,169E-03 0,03845278 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 6,169E-03 0,03834885 ! heart morphogenesis GO:0003007 65 48 2,000 6,169E-03 0,03824548 ! regulation of binding GO:0051098 151 95 3,000 6,462E-03 0,03995356 ! germ cell development GO:0007281 68 49 2,000 6,535E-03 0,0402937 ! regulation of response to external stimulus GO:0032101 139 96 3,000 6,703E-03 0,04122228 ! protein secretion GO:0009306 27 16 1,000 6,712E-03 0,04116827 ! protein amino acid acetylation GO:0006473 28 16 1,000 6,712E-03 0,04105878 ! glial cell development GO:0021782 24 16 1,000 6,712E-03 0,04094987 ! regulation of protein binding GO:0043393 27 16 1,000 6,712E-03 0,04084154 ! neural crest cell migration GO:0001755 24 16 1,000 6,712E-03 0,04073378 ! G1 phase GO:0051318 27 16 1,000 6,712E-03 0,04062658 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 6,712E-03 0,04051995 ! negative regulation of translation GO:0017148 22 16 1,000 6,712E-03 0,04041388 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 6,913E-03 0,04151203 ! regulation of protein catabolic process GO:0042176 77 51 2,000 7,303E-03 0,04374474 ! positive regulation of organelle organization GO:0010638 82 51 2,000 7,303E-03 0,04363112 ! memory GO:0007613 25 17 1,000 7,569E-03 0,04509807 ! cell-substrate junction assembly GO:0007044 39 17 1,000 7,569E-03 0,04498154 ! neuromuscular junction development GO:0007528 23 17 1,000 7,569E-03 0,0448656 ! proximal/distal pattern formation GO:0009954 25 17 1,000 7,569E-03 0,04475027 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 7,569E-03 0,04463552 ! positive regulation of synaptic transmission GO:0050806 24 17 1,000 7,569E-03 0,04452137 ! regulation of translation GO:0006417 151 100 3,000 7,727E-03 0,04533551 ! positive regulation of DNA replication GO:0045740 29 18 1,000 8,472E-03 0,04957928 ! positive regulation of translation GO:0045727 28 18 1,000 8,472E-03 0,04945345 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 8,472E-03 0,04932825 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 8,472E-03 0,04920368 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 8,472E-03 0,04907975 ! visual learning GO:0008542 35 18 1,000 8,472E-03 0,04895643 ! somitogenesis GO:0001756 24 18 1,000 8,472E-03 0,04883373 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 1,000 8,472E-03 0,04871165 ! gut development GO:0048565 26 18 1,000 8,472E-03 0,04859017 ! negative regulation of T cell activation GO:0050868 25 18 1,000 8,472E-03 0,0484693 ! DNA catabolic process GO:0006308 67 54 2,000 8,553E-03 0,04881582 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 9,42E-03 0,05363058 ! response to alkaloid GO:0043279 32 19 1,000 9,42E-03 0,05349816 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 9,42E-03 0,05336639 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 9,42E-03 0,05323527 ! plasma membrane fusion GO:0045026 23 19 1,000 9,42E-03 0,05310479 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 9,42E-03 0,05297495 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 9,42E-03 0,05284575 ! positive regulation of neurological system process GO:0031646 28 19 1,000 9,42E-03 0,05271717 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 9,42E-03 0,05258921 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 9,42E-03 0,05246188 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 9,42E-03 0,05233516 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 9,452E-03 0,05238515 ! chromosome segregation GO:0007059 83 57 2,000 9,921E-03 0,05485358 ! gonad development GO:0008406 79 57 2,000 9,921E-03 0,05472204 ! chromosome condensation GO:0030261 31 20 1,000 0,01041409 0,05730241 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 0,01041409 0,05716565 ! pallium development GO:0021543 38 20 1,000 0,01041409 0,05702954 ! collagen fibril organization GO:0030199 45 20 1,000 0,01041409 0,05689408 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01041409 0,05675926 ! activation of MAPK activity GO:0000187 84 59 2,000 0,01089995 0,05926685 ! regulation of heart contraction GO:0008016 91 60 2,000 0,01140944 0,06189085 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01145213 0,06197621 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01145213 0,06183073 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01145213 0,06168593 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01145213 0,0615418 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01145213 0,06139835 ! dendrite development GO:0016358 35 21 1,000 0,01145213 0,06125556 ! visual behavior GO:0007632 39 21 1,000 0,01145213 0,06111344 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01145213 0,06097197 ! cholesterol biosynthetic process GO:0006695 29 21 1,000 0,01145213 0,06083116 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01145213 0,06069099 ! regulation of multi-organism process GO:0043900 32 21 1,000 0,01145213 0,06055147 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 0,01193249 0,0629466 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,0125337 0,06596685 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 0,0125337 0,06581624 ! leukocyte adhesion GO:0007159 38 22 1,000 0,0125337 0,06566631 ! molting cycle process GO:0022404 40 22 1,000 0,0125337 0,06551707 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,0125337 0,06536851 ! glutamate signaling pathway GO:0007215 34 22 1,000 0,0125337 0,06522062 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,0125337 0,06507339 ! ureteric bud development GO:0001657 32 22 1,000 0,0125337 0,06492683 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,0125337 0,06478093 ! protein tetramerization GO:0051262 39 22 1,000 0,0125337 0,06463568 ! cell cycle checkpoint GO:0000075 108 64 2,000 0,01358343 0,06989236 ! negative regulation of cell size GO:0045792 108 64 2,000 0,01358343 0,06973635 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01365808 0,06996345 ! neuron fate commitment GO:0048663 32 23 1,000 0,01365808 0,06980798 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01365808 0,06965319 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01365808 0,06949909 ! osteoblast differentiation GO:0001649 40 23 1,000 0,01365808 0,06934567 ! interaction with host GO:0051701 37 23 1,000 0,01365808 0,06919293 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01365808 0,06904086 ! regulation of response to biotic stimulus GO:0002831 35 23 1,000 0,01365808 0,06888945 ! liver development GO:0001889 40 23 1,000 0,01365808 0,06873871 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01416118 0,07111508 ! axon guidance GO:0007411 99 66 2,000 0,01475271 0,07392428 ! positive regulation of cell projection organization GO:0031346 39 24 1,000 0,01482455 0,07412275 ! neural crest cell development GO:0014032 39 24 1,000 0,01482455 0,07396197 GO:0014033|neural crest cell differentiation, ! glutathione metabolic process GO:0006749 29 24 1,000 0,01482455 0,07380188 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01482455 0,07364248 ! neurotransmitter secretion GO:0007269 32 24 1,000 0,01482455 0,07348376 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01597731 0,07902754 ! regulation of Ras GTPase activity GO:0032318 110 68 2,000 0,01597731 0,07885795 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,01603239 0,07896039 ! male gonad development GO:0008584 33 25 1,000 0,01603239 0,07879167 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01603239 0,07862367 ! activation of protein kinase activity GO:0032147 102 69 2,000 0,01661042 0,08128506 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,0172809 0,08438657 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,0172809 0,08420779 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,0172809 0,08402976 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,0172809 0,08385248 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01791844 0,08676298 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,01791844 0,08658071 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,01791844 0,0863992 ! acute-phase response GO:0006953 42 27 1,000 0,01856939 0,0893506 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01856939 0,08916407 ! mitochondrion organization GO:0007005 104 73 2,000 0,01928231 0,0923944 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01989715 0,09514232 ! cell junction assembly GO:0034329 56 28 1,000 0,01989715 0,09494493 ! mesoderm formation GO:0001707 46 28 1,000 0,01989715 0,09474836 ! sterol biosynthetic process GO:0016126 40 28 1,000 0,01989715 0,0945526 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01989715 0,09435764 ! protein import into nucleus GO:0006606 118 74 2,000 0,01998523 0,0945803 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,01998523 0,09438609 ! negative regulation of growth GO:0045926 123 75 2,000 0,02070215 0,09757163 ! response to nutrient GO:0007584 104 75 2,000 0,02070215 0,09737209 ! regulation of ligase activity GO:0051340 114 75 2,000 0,02070215 0,09717337 ! nuclear import GO:0051170 121 75 2,000 0,02070215 0,09697546 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,02126353 0,09940267 ! formation of primary germ layer GO:0001704 48 29 1,000 0,02126353 0,09920105 ! tissue homeostasis GO:0001894 42 29 1,000 0,02126353 0,09900023 GO:0048871|multicellular organismal homeostasis, ! protein ubiquitination GO:0016567 125 77 2,000 0,02217805 0,10304953 ! collagen metabolic process GO:0032963 40 30 1,000 0,02266784 0,10511295 ! spindle organization GO:0007051 37 30 1,000 0,02266784 0,10490146 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,02266784 0,10469081 ! hindbrain development GO:0030902 45 30 1,000 0,02266784 0,10448101 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,02266784 0,10427205 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,02266784 0,10406392 ! response to heat GO:0009408 41 30 1,000 0,02266784 0,10385662 ! T cell activation GO:0042110 134 79 2,000 0,02371003 0,10841564 ! glial cell differentiation GO:0010001 55 31 1,000 0,02410941 0,11002312 ! odontogenesis GO:0042476 50 31 1,000 0,02410941 0,10980525 ! segmentation GO:0035282 41 31 1,000 0,02410941 0,10958825 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02410941 0,10937209 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,02410941 0,1091568 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02410941 0,10894234 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02410941 0,10872873 ! cell fate specification GO:0001708 37 31 1,000 0,02410941 0,10851595 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,02449705 0,11004532 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 2,000 0,02449705 0,10983081 ! regulation of GTPase activity GO:0043087 129 80 2,000 0,02449705 0,10961713 ! forebrain development GO:0030900 131 80 2,000 0,02449705 0,10940428 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,02529807 0,11276272 GO:0002696|positive regulation of leukocyte activation, ! regulation of muscle development GO:0048634 48 32 1,000 0,02558761 0,11383268 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02558761 0,11361292 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02558761 0,11339401 ! meiosis I GO:0007127 52 32 1,000 0,02558761 0,11317595 ! regulation of ARF protein signal transduction GO:0032012 51 32 1,000 0,02558761 0,11295872 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02558761 0,11274232 ! cytokine production GO:0001816 44 32 1,000 0,02558761 0,11252676 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02558761 0,11231201 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02710176 0,11873154 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02710176 0,11850581 ! ear morphogenesis GO:0042471 42 33 1,000 0,02710176 0,11828094 ! cell junction organization GO:0034330 63 33 1,000 0,02710176 0,11805693 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02710176 0,11783376 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02710176 0,11761143 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02710176 0,11738994 ! cytokinesis GO:0000910 52 33 1,000 0,02710176 0,11716928 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 0,02864207 0,12359617 ! transcription initiation GO:0006352 118 85 2,000 0,02864207 0,12336472 ! regulation of membrane potential GO:0042391 128 85 2,000 0,02864207 0,12313413 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02865125 0,12294379 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,02865125 0,12271484 ! neuron migration GO:0001764 46 34 1,000 0,02865125 0,12248675 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,03023543 0,12901944 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,03023543 0,12878052 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,03039778 0,12923269 GO:0060538|skeletal muscle organ development, ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,03129648 0,13280796 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03185367 0,13492347 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,03185367 0,13467545 ! neural tube development GO:0021915 50 36 1,000 0,03185367 0,13442834 ! regulation of T cell activation GO:0050863 128 89 2,000 0,03220906 0,1356792 ! leukocyte differentiation GO:0002521 143 90 2,000 0,03313548 0,13932651 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,03313548 0,13907226 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,03350537 0,14036858 ! amino acid activation GO:0043038 52 37 1,000 0,03350537 0,14011336 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cell fate commitment GO:0045165 141 92 2,000 0,03502971 0,14622201 ! sulfur metabolic process GO:0006790 118 92 2,000 0,03502971 0,14595711 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03518991 0,14635947 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,03599745 0,1494479 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,03690668 0,15294662 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,03690668 0,15267153 ! cell growth GO:0016049 61 39 1,000 0,03690668 0,15239744 ! synapse organization GO:0050808 55 39 1,000 0,03690668 0,15212432 ! angiogenesis GO:0001525 149 95 2,000 0,03797401 0,15624371 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03830096 0,15730751 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03830096 0,15702711 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03830096 0,1567477 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03830096 0,15646928 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03830096 0,15619186 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03830096 0,15591541 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03830096 0,15563994 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03830096 0,15536544 ! sleep GO:0030431 11 5 0,000 0,03830096 0,15509191 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03830096 0,15481934 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03830096 0,15454773 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03830096 0,15427707 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 0,03830096 0,15400736 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03830096 0,15373858 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03830096 0,15347074 ! cobalt ion transport GO:0006824 9 5 0,000 0,03830096 0,15320384 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03830096 0,15293786 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03830096 0,1526728 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03830096 0,15240866 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03830096 0,15214544 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03830096 0,15188312 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03830096 0,1516217 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03830096 0,15136118 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03830096 0,15110156 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03830096 0,15084282 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03830096 0,15058497 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03830096 0,150328 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03830096 0,1500719 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03830096 0,14981668 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03830096 0,14956232 ! malate metabolic process GO:0006108 7 5 0,000 0,03830096 0,14930883 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03830096 0,14905619 ! behavioral response to pain GO:0048266 7 5 0,000 0,03830096 0,1488044 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03830096 0,14855347 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03830096 0,14830338 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03830096 0,14805413 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03830096 0,14780572 ! mating behavior GO:0007617 6 5 0,000 0,03830096 0,14755814 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03830096 0,14731138 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03830096 0,14706545 ! rhythmic behavior GO:0007622 12 5 0,000 0,03830096 0,14682035 ! copulation GO:0007620 7 5 0,000 0,03830096 0,14657605 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03830096 0,14633257 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03830096 0,1460899 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03830096 0,14584803 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03830096 0,14560695 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03830096 0,14536668 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03830096 0,14512719 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03830096 0,1448885 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03830096 0,14465059 ! response to protozoan GO:0001562 9 5 0,000 0,03830096 0,14441345 ! lymph vessel development GO:0001945 7 5 0,000 0,03830096 0,1441771 ! endochondral ossification GO:0001958 12 5 0,000 0,03830096 0,14394151 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03830096 0,1437067 ! parathyroid gland development GO:0060017 8 5 0,000 0,03830096 0,14347265 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03830096 0,14323936 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03830096 0,14300683 ! nuclear migration GO:0007097 10 5 0,000 0,03830096 0,14277505 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03830096 0,14254402 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03830096 0,14231374 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03830096 0,14208421 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03830096 0,14185541 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03830096 0,14162734 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03830096 0,14140001 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03830096 0,14117341 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03830096 0,14094753 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03830096 0,14072238 ! ovulation GO:0030728 6 5 0,000 0,03830096 0,14049794 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03830096 0,14027422 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 9 5 0,000 0,03830096 0,1400512 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03830096 0,1398289 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03830096 0,1396073 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03830096 0,1393864 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03830096 0,1391662 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03830096 0,1389467 ! polyol catabolic process GO:0046174 7 5 0,000 0,03830096 0,13872789 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03830096 0,13850976 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03830096 0,13829232 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03830096 0,13807556 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03830096 0,13785948 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03830096 0,13764407 ! urea metabolic process GO:0019627 6 5 0,000 0,03830096 0,13742934 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03830096 0,13721528 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03830096 0,13700188 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03830096 0,13678914 ! neutrophil activation GO:0042119 5 5 0,000 0,03830096 0,13657707 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03830096 0,13636565 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03830096 0,13615488 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03830096 0,13594476 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03830096 0,1357353 ! forebrain neuron development GO:0021884 7 5 0,000 0,03830096 0,13552647 ! melanosome organization GO:0032438 7 5 0,000 0,03830096 0,13531829 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03830096 0,13511075 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03830096 0,13490384 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03830096 0,13469756 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03830096 0,13449192 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03830096 0,1342869 ! nucleoside transport GO:0015858 6 5 0,000 0,03830096 0,13408251 ! nucleoside salvage GO:0043174 7 5 0,000 0,03830096 0,13387873 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03830096 0,13367558 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03830096 0,13347304 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03830096 0,13327112 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03830096 0,1330698 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03830096 0,13286909 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03830096 0,13266899 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03830096 0,13246948 ! depyrimidination GO:0045008 8 5 0,000 0,03830096 0,13227058 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03830096 0,13207227 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03830096 0,13187456 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03830096 0,13167744 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03830096 0,13148091 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03830096 0,13128496 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03830096 0,13108959 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03830096 0,13089481 ! monocyte differentiation GO:0030224 8 5 0,000 0,03830096 0,1307006 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03830096 0,13050697 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 5 5 0,000 0,03830096 0,13031392 ! response to UV-C GO:0010225 6 5 0,000 0,03830096 0,13012143 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03830096 0,12992951 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03830096 0,12973815 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03830096 0,12954736 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03830096 0,12935713 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03830096 0,12916746 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03830096 0,12897834 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03830096 0,12878978 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03830096 0,12860176 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03830096 0,1284143 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03830096 0,12822738 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03830096 0,128041 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03830096 0,12785516 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03830096 0,12766987 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03830096 0,1274851 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03830096 0,12730088 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03830096 0,12711718 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03830096 0,12693402 ! neural tube patterning GO:0021532 6 5 0,000 0,03830096 0,12675138 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03830096 0,12656926 ! histone demethylation GO:0016577 9 5 0,000 0,03830096 0,12638767 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03830096 0,1262066 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03830096 0,12602605 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03830096 0,12584601 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03830096 0,12566649 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03830096 0,12548747 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03830096 0,12530897 ! transcription termination GO:0006353 8 5 0,000 0,03830096 0,12513098 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03830096 0,12495349 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03830096 0,1247765 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03830096 0,12460001 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03830096 0,12442402 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03830096 0,12424853 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03830096 0,12407353 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03830096 0,12389903 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03830096 0,12372501 ! apical protein localization GO:0045176 6 5 0,000 0,03830096 0,12355148 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03830096 0,12337844 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03830096 0,12320588 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03830096 0,12303381 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03830096 0,12286221 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03830096 0,1226911 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03830096 0,12252045 ! glial cell migration GO:0008347 10 5 0,000 0,03830096 0,12235029 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03830096 0,12218059 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03830096 0,12201137 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03830096 0,12184261 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03830096 0,12167432 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03830096 0,12150649 ! neural plate development GO:0001840 6 5 0,000 0,03830096 0,12133913 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03830096 0,12117222 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03830096 0,12100578 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03830096 0,12083979 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03830096 0,12067426 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03830096 0,12050918 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03830096 0,12034455 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03830096 0,12018036 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03830096 0,12001663 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03830096 0,11985334 ! spindle assembly GO:0051225 5 5 0,000 0,03830096 0,1196905 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03830096 0,1195281 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03830096 0,11936613 ! organ regeneration GO:0031100 7 5 0,000 0,03830096 0,11920461 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03830096 0,11904352 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03830096 0,11888287 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03830096 0,11872265 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03830096 0,11856286 GO:0055081|anion homeostasis, ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,0386551 0,1194983 ! peptide metabolic process GO:0006518 56 40 1,000 0,0386551 0,1193379 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,0386551 0,11917793 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,0386551 0,11901839 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,03898275 0,11986676 ! glucose transport GO:0015758 52 41 1,000 0,04043458 0,12416492 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,04043458 0,12399937 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,04043458 0,12383425 ! extracellular structure organization GO:0043062 156 99 2,000 0,04209028 0,12873357 ! protein import GO:0017038 156 99 2,000 0,04209028 0,12856261 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,04224452 0,1288626 ! cellular component disassembly GO:0022411 64 42 1,000 0,04224452 0,12869192 ! hexose transport GO:0008645 54 42 1,000 0,04224452 0,12852169 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,04224452 0,12835192 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,04224452 0,12818259 ! protein localization in organelle GO:0033365 161 100 2,000 0,04315307 0,13076688 ! activation of caspase activity GO:0006919 65 43 1,000 0,04408437 0,13341322 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,04408437 0,13323791 ! tRNA transcription GO:0009304 11 6 0,000 0,04578457 0,1381949 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04578457 0,13801378 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04578457 0,13783313 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04578457 0,13765296 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04578457 0,13747325 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04578457 0,13729402 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04578457 0,13711525 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04578457 0,13693695 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04578457 0,13675911 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04578457 0,13658173 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04578457 0,13640481 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04578457 0,13622835 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04578457 0,13605234 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04578457 0,13587679 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04578457 0,13570169 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04578457 0,13552704 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04578457 0,13535284 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04578457 0,13517909 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04578457 0,13500579 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04578457 0,13483292 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04578457 0,1346605 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04578457 0,13448852 ! signal peptide processing GO:0006465 8 6 0,000 0,04578457 0,13431698 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04578457 0,13414588 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04578457 0,13397521 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04578457 0,13380497 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04578457 0,13363517 ! opsonization GO:0008228 8 6 0,000 0,04578457 0,1334658 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04578457 0,13329685 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04578457 0,13312833 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04578457 0,13296024 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04578457 0,13279258 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04578457 0,13262533 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04578457 0,13245851 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04578457 0,1322921 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04578457 0,13212611 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04578457 0,13196054 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04578457 0,13179538 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04578457 0,13163064 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04578457 0,13146631 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04578457 0,13130238 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04578457 0,13113887 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04578457 0,13097576 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04578457 0,13081306 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04578457 0,13065076 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04578457 0,13048886 ! thymic T cell selection GO:0045061 12 6 0,000 0,04578457 0,13032737 ! protein lipoylation GO:0009249 10 6 0,000 0,04578457 0,13016627 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04578457 0,13000557 ! pigment granule organization GO:0048753 11 6 0,000 0,04578457 0,12984527 ! drug transport GO:0015893 6 6 0,000 0,04578457 0,12968536 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04578457 0,12952585 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04578457 0,12936672 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04578457 0,12920799 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04578457 0,12904965 ! histidine metabolic process GO:0006547 6 6 0,000 0,04578457 0,12889169 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04578457 0,12873412 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04578457 0,12857694 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04578457 0,12842014 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04578457 0,12826372 ! adenohypophysis development GO:0021984 10 6 0,000 0,04578457 0,12810768 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04578457 0,12795202 ! hyperosmotic response GO:0006972 8 6 0,000 0,04578457 0,12779674 ! microtubule nucleation GO:0007020 10 6 0,000 0,04578457 0,12764183 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04578457 0,1274873 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04578457 0,12733315 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04578457 0,12717936 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04578457 0,12702595 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04578457 0,12687291 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04578457 0,12672023 ! response to dietary excess GO:0002021 7 6 0,000 0,04578457 0,12656792 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04578457 0,12641598 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04578457 0,1262644 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04578457 0,12611319 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04578457 0,12596234 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04578457 0,12581184 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04578457 0,12566171 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04578457 0,12551193 ! neuron apoptosis GO:0051402 8 6 0,000 0,04578457 0,12536251 ! organic alcohol transport GO:0015850 9 6 0,000 0,04578457 0,12521345 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04578457 0,12506474 ! carnitine transport GO:0015879 8 6 0,000 0,04578457 0,12491638 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04578457 0,12476838 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04578457 0,12462072 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04578457 0,12447342 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04578457 0,12432646 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04578457 0,12417985 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04578457 0,12403358 ! parturition GO:0007567 12 6 0,000 0,04578457 0,12388766 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04578457 0,12374208 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04578457 0,12359685 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04578457 0,12345195 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04578457 0,12330739 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04578457 0,12316317 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04578457 0,12301929 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04578457 0,12287574 ! macrophage differentiation GO:0030225 10 6 0,000 0,04578457 0,12273253 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04578457 0,12258965 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04578457 0,12244711 ! interaction with symbiont GO:0051702 8 6 0,000 0,04578457 0,12230489 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04578457 0,12216301 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04578457 0,12202145 ! eating behavior GO:0042755 6 6 0,000 0,04578457 0,12188022 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04578457 0,12173932 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04578457 0,12159874 ! response to copper ion GO:0046688 9 6 0,000 0,04578457 0,12145849 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04578457 0,12131856 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04578457 0,12117896 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04578457 0,12103967 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04578457 0,1209007 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04578457 0,12076206 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04578457 0,12062373 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04578457 0,12048571 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04578457 0,12034801 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04578457 0,12021063 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04578457 0,12007356 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04578457 0,1199368 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04578457 0,11980036 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04578457 0,11966422 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04578457 0,11952839 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04578457 0,11939287 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04578457 0,11925766 ! histone ubiquitination GO:0016574 7 6 0,000 0,04578457 0,11912275 ! regulation of meiosis GO:0040020 10 6 0,000 0,04578457 0,11898815 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04578457 0,11885385 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04578457 0,11871986 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04578457 0,11858616 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04578457 0,11845277 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04578457 0,11831968 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04578457 0,11818688 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04578457 0,11805439 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04578457 0,11792219 ! receptor internalization GO:0031623 9 6 0,000 0,04578457 0,11779028 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04578457 0,11765867 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04578457 0,11752736 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04578457 0,11739633 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04578457 0,1172656 ! protein deubiquitination GO:0016579 8 6 0,000 0,04578457 0,11713516 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04578457 0,11700501 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04578457 0,11687515 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04578457 0,11674558 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04578457 0,11661629 ! midbrain development GO:0030901 6 6 0,000 0,04578457 0,11648729 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04578457 0,11635858 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04578457 0,11623015 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04578457 0,116102 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04578457 0,11597413 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04578457 0,11584655 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04578457 0,11571924 GO:0046479|glycosphingolipid catabolic process, ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04578457 0,11559222 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04578457 0,11546547 ! adult feeding behavior GO:0008343 6 6 0,000 0,04578457 0,11533901 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04578457 0,11521281 ! blastocyst growth GO:0001832 15 6 0,000 0,04578457 0,1150869 ! pigment granule transport GO:0051904 12 6 0,000 0,04578457 0,11496126 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04578457 0,11483589 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04578457 0,1147108 ! catecholamine transport GO:0051937 7 6 0,000 0,04578457 0,11458598 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04578457 0,11446143 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04578457 0,11433715 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04578457 0,11421314 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04578457 0,1140894 ! protein prenylation GO:0018342 10 6 0,000 0,04578457 0,11396592 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04578457 0,11384272 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04578457 0,11371978 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04578457 0,1135971 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04578457 0,11347469 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,04595355 0,11377089 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04595355 0,11364855 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,0478515 0,11821529 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,04977766 0,12284187 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04977766 0,12271021 ! regulation of ossification GO:0030278 71 46 1,000 0,04977766 0,12257883 ! histone modification GO:0016570 68 46 1,000 0,04977766 0,12244773 ! endocrine system development GO:0035270 83 47 1,000 0,0517315 0,12711801 ! covalent chromatin modification GO:0016569 75 47 1,000 0,0517315 0,12698234 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,0517315 0,12684697 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,0517315 0,12671188 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05321037 0,13019559 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05321037 0,13005723 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05321037 0,12991917 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05321037 0,12978139 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05321037 0,12964391 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05321037 0,12950672 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05321037 0,12936983 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05321037 0,12923322 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05321037 0,12909689 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05321037 0,12896086 ! reproductive behavior GO:0019098 12 7 0,000 0,05321037 0,12882511 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05321037 0,12868965 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05321037 0,12855447 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05321037 0,12841957 ! oligopeptide transport GO:0006857 11 7 0,000 0,05321037 0,12828496 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05321037 0,12815063 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05321037 0,12801658 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05321037 0,12788282 ! RNA methylation GO:0001510 11 7 0,000 0,05321037 0,12774933 ! pericardium development GO:0060039 8 7 0,000 0,05321037 0,12761612 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05321037 0,12748318 ! fibril organization GO:0043206 13 7 0,000 0,05321037 0,12735053 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05321037 0,12721814 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05321037 0,12708604 ! lipoprotein transport GO:0042953 9 7 0,000 0,05321037 0,12695421 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05321037 0,12682265 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05321037 0,12669136 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05321037 0,12656035 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05321037 0,1264296 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05321037 0,12629913 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05321037 0,12616892 ! chemosensory behavior GO:0007635 9 7 0,000 0,05321037 0,12603899 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05321037 0,12590932 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05321037 0,12577991 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05321037 0,12565077 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05321037 0,1255219 ! reflex GO:0060004 12 7 0,000 0,05321037 0,12539329 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05321037 0,12526495 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05321037 0,12513687 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05321037 0,12500904 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05321037 0,12488148 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05321037 0,12475418 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05321037 0,12462714 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05321037 0,12450036 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05321037 0,12437384 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05321037 0,12424757 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05321037 0,12412156 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05321037 0,1239958 ! endosome organization GO:0007032 10 7 0,000 0,05321037 0,1238703 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05321037 0,12374505 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05321037 0,12362006 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05321037 0,12349531 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05321037 0,12337082 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05321037 0,12324658 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05321037 0,12312259 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05321037 0,12299885 ! galactose metabolic process GO:0006012 10 7 0,000 0,05321037 0,12287536 ! vesicle fusion GO:0006906 15 7 0,000 0,05321037 0,12275211 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05321037 0,12262911 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05321037 0,12250636 ! organ growth GO:0035265 11 7 0,000 0,05321037 0,12238385 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05321037 0,12226159 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05321037 0,12213958 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05321037 0,1220178 ! retinol metabolic process GO:0042572 9 7 0,000 0,05321037 0,12189627 ! behavioral fear response GO:0001662 13 7 0,000 0,05321037 0,12177498 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05321037 0,12165393 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05321037 0,12153312 ! rRNA modification GO:0000154 12 7 0,000 0,05321037 0,12141255 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05321037 0,12129222 ! response to UV-B GO:0010224 11 7 0,000 0,05321037 0,12117213 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,05321037 0,12105228 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05321037 0,12093266 ! intermediate filament organization GO:0045109 11 7 0,000 0,05321037 0,12081328 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05321037 0,12069414 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05321037 0,12057523 ! fibrinolysis GO:0042730 9 7 0,000 0,05321037 0,12045655 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05321037 0,12033811 ! B cell lineage commitment GO:0002326 17 7 0,000 0,05321037 0,1202199 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05321037 0,12010192 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05321037 0,11998417 ! response to tropane GO:0014073 13 7 0,000 0,05321037 0,11986666 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05321037 0,11974937 ! melanosome localization GO:0032400 10 7 0,000 0,05321037 0,11963231 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05321037 0,11951548 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05321037 0,11939888 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05321037 0,11928251 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05321037 0,11916636 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05321037 0,11905044 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05321037 0,11893475 ! mast cell activation GO:0045576 9 7 0,000 0,05321037 0,11881928 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05321037 0,11870403 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05321037 0,11858901 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05321037 0,11847421 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05321037 0,11835963 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05321037 0,11824527 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05321037 0,11813113 ! T cell lineage commitment GO:0002360 12 7 0,000 0,05321037 0,11801722 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05321037 0,11790352 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05321037 0,11779004 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05321037 0,11767678 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05321037 0,11756374 ! response to tumor cell GO:0002347 12 7 0,000 0,05321037 0,11745092 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05321037 0,11733831 ! neuroblast proliferation GO:0007405 13 7 0,000 0,05321037 0,11722591 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05321037 0,11711374 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05321037 0,11700177 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,05321037 0,11689002 ! diuresis GO:0030146 12 7 0,000 0,05321037 0,11677849 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05321037 0,11666716 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05321037 0,11655605 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05321037 0,11644515 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05321037 0,11633446 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05321037 0,11622398 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05321037 0,11611371 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05321037 0,11600365 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05321037 0,1158938 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05321037 0,11578416 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05321037 0,11567472 ! lymph node development GO:0048535 9 7 0,000 0,05321037 0,11556549 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05321037 0,11545647 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05321037 0,11534765 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05321037 0,11523903 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05321037 0,11513063 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05321037 0,11502242 ! ATP catabolic process GO:0006200 10 7 0,000 0,05321037 0,11491442 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05321037 0,11480662 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05321037 0,11469902 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05321037 0,11459162 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05321037 0,11448443 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05321037 0,11437743 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05321037 0,11427064 ! muscle adaptation GO:0043500 12 7 0,000 0,05321037 0,11416404 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05321037 0,11405765 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05321037 0,11395145 ! retina homeostasis GO:0001895 9 7 0,000 0,05321037 0,11384545 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05321037 0,11373964 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05321037 0,11363403 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05321037 0,11352862 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05321037 0,11342341 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05321037 0,11331838 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05321037 0,11321356 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05321037 0,11310892 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,05371247 0,11407081 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,05371247 0,11396558 ! gastrulation GO:0007369 73 48 1,000 0,05371247 0,11386054 ! regulation of DNA replication GO:0006275 75 48 1,000 0,05371247 0,1137557 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,05371247 0,11365105 ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,05371247 0,11354659 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,05371247 0,11344232 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,05371247 0,11333825 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,05572004 0,11746664 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,05572004 0,11735907 ! ear development GO:0043583 72 50 1,000 0,05775368 0,12153108 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05775368 0,12142 ! membrane fusion GO:0006944 80 50 1,000 0,05775368 0,12130911 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,05775368 0,12119843 ! lipid modification GO:0030258 73 50 1,000 0,05775368 0,12108794 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05981288 0,12529109 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,05981288 0,12517709 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06057881 0,12666478 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06057881 0,12654973 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,06057881 0,12643489 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06057881 0,12632027 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06057881 0,12620585 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06057881 0,12609163 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06057881 0,12597763 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06057881 0,12586382 ! phosphate transport GO:0006817 10 8 0,000 0,06057881 0,12575023 ! N-glycan processing GO:0006491 12 8 0,000 0,06057881 0,12563684 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06057881 0,12552365 ! UTP metabolic process GO:0046051 8 8 0,000 0,06057881 0,12541067 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06057881 0,12529789 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06057881 0,12518531 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06057881 0,12507294 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06057881 0,12496077 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06057881 0,12484879 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06057881 0,12473702 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06057881 0,12462545 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06057881 0,12451408 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06057881 0,12440291 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06057881 0,12429193 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06057881 0,12418115 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06057881 0,12407057 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06057881 0,12396019 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06057881 0,12385 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06057881 0,12374001 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06057881 0,12363022 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06057881 0,12352061 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06057881 0,12341121 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06057881 0,12330199 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06057881 0,12319297 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06057881 0,12308415 ! melanin metabolic process GO:0006582 12 8 0,000 0,06057881 0,12297551 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06057881 0,12286707 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06057881 0,12275881 ! macrophage activation GO:0042116 12 8 0,000 0,06057881 0,12265075 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06057881 0,12254288 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06057881 0,1224352 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,06057881 0,1223277 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06057881 0,1222204 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06057881 0,12211328 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06057881 0,12200635 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06057881 0,12189961 ! ruffle organization GO:0031529 11 8 0,000 0,06057881 0,12179305 ! osteoblast development GO:0002076 13 8 0,000 0,06057881 0,12168668 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06057881 0,1215805 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06057881 0,1214745 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06057881 0,12136869 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06057881 0,12126306 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06057881 0,12115761 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06057881 0,12105235 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06057881 0,12094727 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06057881 0,12084237 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06057881 0,12073765 ! segment specification GO:0007379 10 8 0,000 0,06057881 0,12063312 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,06057881 0,12052877 ! cellular extravasation GO:0045123 11 8 0,000 0,06057881 0,12042459 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06057881 0,1203206 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06057881 0,12021678 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06057881 0,12011315 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06057881 0,12000969 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06057881 0,11990641 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,06057881 0,11980331 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06057881 0,11970039 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,06057881 0,11959764 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06057881 0,11949507 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06057881 0,11939268 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06057881 0,11929046 ! icosanoid secretion GO:0032309 12 8 0,000 0,06057881 0,11918841 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06057881 0,11908654 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06057881 0,11898485 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06057881 0,11888332 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06057881 0,11878197 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06057881 0,1186808 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06057881 0,11857979 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06057881 0,11847896 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06057881 0,1183783 ! sterol catabolic process GO:0016127 9 8 0,000 0,06057881 0,1182778 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06057881 0,11817748 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06057881 0,11807733 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06057881 0,11797735 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06057881 0,11787754 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06057881 0,1177779 ! prophase GO:0051324 11 8 0,000 0,06057881 0,11767842 ! S phase GO:0051320 8 8 0,000 0,06057881 0,11757912 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06057881 0,11747998 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,06057881 0,11738101 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06057881 0,1172822 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06057881 0,11718356 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06057881 0,11708509 ! hormone catabolic process GO:0042447 13 8 0,000 0,06057881 0,11698678 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06057881 0,11688864 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06057881 0,11679066 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06057881 0,11669284 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06057881 0,11659519 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06057881 0,1164977 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06057881 0,11640038 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06057881 0,11630322 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06057881 0,11620622 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06057881 0,11610938 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06057881 0,1160127 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06057881 0,11591618 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06057881 0,11581983 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06057881 0,11572363 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,06189711 0,11814386 ! establishment of organelle localization GO:0051656 85 52 1,000 0,06189711 0,11804589 ! regulation of neurotransmitter levels GO:0001505 73 53 1,000 0,06400587 0,12196644 ! cell projection assembly GO:0030031 76 53 1,000 0,06400587 0,12186547 ! detection of external stimulus GO:0009581 66 54 1,000 0,06613865 0,12582209 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,06613865 0,1257181 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,06613865 0,12561429 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,06613865 0,12551065 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06789031 0,12872854 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06789031 0,1286225 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06789031 0,12851664 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06789031 0,12841095 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06789031 0,12830544 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06789031 0,1282001 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06789031 0,12809493 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06789031 0,12798994 ! GTP metabolic process GO:0046039 9 9 0,000 0,06789031 0,12788511 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06789031 0,12778046 ! social behavior GO:0035176 14 9 0,000 0,06789031 0,12767598 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06789031 0,12757167 ! regulation of histone modification GO:0031056 11 9 0,000 0,06789031 0,12746753 ! response to pain GO:0048265 16 9 0,000 0,06789031 0,12736356 ! protein complex disassembly GO:0043241 17 9 0,000 0,06789031 0,12725976 GO:0043624|cellular protein complex disassembly, ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06789031 0,12715612 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06789031 0,12705266 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06789031 0,12694937 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06789031 0,12684624 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06789031 0,12674328 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06789031 0,12664049 ! protein targeting to ER GO:0045047 19 9 0,000 0,06789031 0,12653786 ! T cell selection GO:0045058 18 9 0,000 0,06789031 0,1264354 ! endoderm development GO:0007492 12 9 0,000 0,06789031 0,12633311 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06789031 0,12623098 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06789031 0,12612902 ! arginine catabolic process GO:0006527 10 9 0,000 0,06789031 0,12602722 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06789031 0,12592558 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06789031 0,12582411 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06789031 0,1257228 ! V(D)J recombination GO:0033151 12 9 0,000 0,06789031 0,12562166 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06789031 0,12552068 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06789031 0,12541986 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06789031 0,1253192 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06789031 0,1252187 ! mannose metabolic process GO:0006013 9 9 0,000 0,06789031 0,12511837 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06789031 0,12501819 ! receptor clustering GO:0043113 15 9 0,000 0,06789031 0,12491818 ! epithelial cell development GO:0002064 10 9 0,000 0,06789031 0,12481832 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06789031 0,12471863 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06789031 0,12461909 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06789031 0,12451971 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06789031 0,12442049 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06789031 0,12432143 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06789031 0,12422253 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06789031 0,12412378 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06789031 0,1240252 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06789031 0,12392676 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06789031 0,12382849 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06789031 0,12373037 ! response to amine stimulus GO:0014075 13 9 0,000 0,06789031 0,1236324 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06789031 0,12353459 ! erythrocyte development GO:0048821 11 9 0,000 0,06789031 0,12343693 ! renal water homeostasis GO:0003091 14 9 0,000 0,06789031 0,12333943 ! postreplication repair GO:0006301 11 9 0,000 0,06789031 0,12324208 ! mRNA cleavage GO:0006379 13 9 0,000 0,06789031 0,12314489 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06789031 0,12304785 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06789031 0,12295096 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06789031 0,12285423 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06789031 0,12275764 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06789031 0,12266121 ! acid secretion GO:0046717 14 9 0,000 0,06789031 0,12256493 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06789031 0,1224688 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06789031 0,12237282 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06789031 0,12227699 ! purine base metabolic process GO:0006144 18 9 0,000 0,06789031 0,12218132 ! oocyte differentiation GO:0009994 12 9 0,000 0,06789031 0,12208579 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,06789031 0,12199041 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06789031 0,12189518 ! spleen development GO:0048536 15 9 0,000 0,06789031 0,12180009 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06789031 0,12170516 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06789031 0,12161037 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06789031 0,12151574 ! detection of calcium ion GO:0005513 13 9 0,000 0,06789031 0,12142124 ! blastocyst formation GO:0001825 12 9 0,000 0,06789031 0,1213269 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06789031 0,1212327 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06789031 0,12113865 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06789031 0,12104474 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06789031 0,12095098 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06789031 0,12085737 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06789031 0,1207639 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06789031 0,12067057 ! prepulse inhibition GO:0060134 14 9 0,000 0,06789031 0,12057739 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06789031 0,12048435 ! insulin secretion GO:0030073 17 9 0,000 0,06789031 0,12039146 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06789031 0,12029871 ! response to nicotine GO:0035094 16 9 0,000 0,06789031 0,1202061 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06789031 0,12011363 ! nucleus localization GO:0051647 15 9 0,000 0,06789031 0,12002131 ! exocytosis GO:0006887 74 55 1,000 0,06829498 0,12064397 ! carbohydrate transport GO:0008643 74 57 1,000 0,07267627 0,12828505 ! developmental maturation GO:0021700 75 57 1,000 0,07267627 0,12818667 ! viral reproductive process GO:0022415 87 58 1,000 0,07490028 0,13200816 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,07490028 0,13190708 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07514533 0,13223738 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07514533 0,13213628 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07514533 0,13203534 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07514533 0,13193455 ! thyroid gland development GO:0030878 19 10 0,000 0,07514533 0,13183391 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07514533 0,13173343 ! synapsis GO:0007129 13 10 0,000 0,07514533 0,1316331 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07514533 0,13153292 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07514533 0,1314329 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07514533 0,13133302 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07514533 0,1312333 ! sulfate transport GO:0008272 12 10 0,000 0,07514533 0,13113373 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07514533 0,13103431 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07514533 0,13093505 ! androgen metabolic process GO:0008209 13 10 0,000 0,07514533 0,13083593 ! phospholipid efflux GO:0033700 16 10 0,000 0,07514533 0,13073696 ! hippocampus development GO:0021766 19 10 0,000 0,07514533 0,13063814 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07514533 0,13053947 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07514533 0,13044095 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07514533 0,13034258 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07514533 0,13024436 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07514533 0,13014628 ! pathogenesis GO:0009405 13 10 0,000 0,07514533 0,13004835 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07514533 0,12995057 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07514533 0,12985294 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07514533 0,12975545 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07514533 0,12965811 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07514533 0,12956092 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07514533 0,12946387 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07514533 0,12936696 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07514533 0,1292702 ! response to X-ray GO:0010165 16 10 0,000 0,07514533 0,12917359 ! B cell proliferation GO:0042100 14 10 0,000 0,07514533 0,12907712 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07514533 0,12898079 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07514533 0,12888461 ! forebrain cell migration GO:0021885 17 10 0,000 0,07514533 0,12878857 ! lipid digestion GO:0044241 15 10 0,000 0,07514533 0,12869267 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07514533 0,12859692 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07514533 0,12850131 ! UV protection GO:0009650 14 10 0,000 0,07514533 0,12840584 ! entry into host cell GO:0030260 20 10 0,000 0,07514533 0,12831051 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07514533 0,12821533 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07514533 0,12812028 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07514533 0,12802538 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,07514533 0,12793061 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07514533 0,12783599 ! regulation of organ growth GO:0046620 11 10 0,000 0,07514533 0,12774151 ! response to dsRNA GO:0043331 18 10 0,000 0,07514533 0,12764716 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07514533 0,12755296 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07514533 0,12745889 ! embryonic axis specification GO:0000578 12 10 0,000 0,07514533 0,12736497 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07514533 0,12727118 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07514533 0,12717753 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07514533 0,12708402 ! fucose catabolic process GO:0019317 16 10 0,000 0,07514533 0,12699064 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07514533 0,1268974 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07514533 0,1268043 ! protein sumoylation GO:0016925 12 10 0,000 0,07514533 0,12671133 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07514533 0,12661851 ! zymogen activation GO:0031638 14 10 0,000 0,07514533 0,12652581 ! salivary gland development GO:0007431 22 10 0,000 0,07514533 0,12643326 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07514533 0,12634083 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07514533 0,12624855 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07514533 0,12615639 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07514533 0,12606438 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07514533 0,12597249 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07514533 0,12588074 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07514533 0,12578913 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07514533 0,12569764 ! detection of bacterium GO:0016045 10 10 0,000 0,07514533 0,12560629 ! activation of innate immune response GO:0002218 10 10 0,000 0,07514533 0,12551508 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07514533 0,12542399 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07514533 0,12533304 ! developmental induction GO:0031128 13 10 0,000 0,07514533 0,12524222 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07514533 0,12515153 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07514533 0,12506097 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07514533 0,12497054 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07941268 0,13197194 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,07941268 0,13187665 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,07941268 0,1317815 ! meiosis GO:0007126 96 61 1,000 0,08170015 0,13547969 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,08170015 0,13538208 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,08170015 0,13528462 ! extracellular matrix organization GO:0030198 103 61 1,000 0,08170015 0,13518729 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,08170015 0,1350901 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! rRNA transcription GO:0009303 17 11 0,000 0,08234429 0,13605738 ! respiratory burst GO:0045730 14 11 0,000 0,08234429 0,13595971 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08234429 0,13586217 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,08234429 0,13576478 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08234429 0,13566753 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,08234429 0,13557041 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,08234429 0,13547344 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08234429 0,1353766 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08234429 0,13527991 ! mating GO:0007618 14 11 0,000 0,08234429 0,13518335 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,08234429 0,13508693 ! T cell proliferation GO:0042098 20 11 0,000 0,08234429 0,13499064 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08234429 0,13489449 ! bone resorption GO:0045453 16 11 0,000 0,08234429 0,13479848 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08234429 0,13470261 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08234429 0,13460687 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,08234429 0,13451127 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08234429 0,13441581 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,08234429 0,13432047 ! syncytium formation GO:0006949 15 11 0,000 0,08234429 0,13422528 ! plasma membrane organization GO:0007009 18 11 0,000 0,08234429 0,13413022 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08234429 0,13403529 ! focal adhesion formation GO:0048041 24 11 0,000 0,08234429 0,1339405 ! mitotic spindle organization GO:0007052 15 11 0,000 0,08234429 0,13384584 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08234429 0,13375132 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,08234429 0,13365693 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08234429 0,13356267 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08234429 0,13346855 ! adult heart development GO:0007512 11 11 0,000 0,08234429 0,13337456 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,08234429 0,1332807 ! temperature homeostasis GO:0001659 16 11 0,000 0,08234429 0,13318697 ! L-glutamate transport GO:0015813 16 11 0,000 0,08234429 0,13309337 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08234429 0,13299991 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08234429 0,13290658 ! stem cell development GO:0048864 29 11 0,000 0,08234429 0,13281337 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08234429 0,1327203 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08234429 0,13262736 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08234429 0,13253455 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08234429 0,13244187 ! vasoconstriction GO:0042310 15 11 0,000 0,08234429 0,13234931 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08234429 0,13225689 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08234429 0,1321646 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08234429 0,13207243 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08234429 0,1319804 ! ribosome assembly GO:0042255 13 11 0,000 0,08234429 0,13188849 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08234429 0,13179671 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08234429 0,13170506 ! chromatin silencing GO:0006342 19 11 0,000 0,08234429 0,13161353 ! nucleosome positioning GO:0016584 13 11 0,000 0,08234429 0,13152213 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08234429 0,13143086 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08234429 0,13133972 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08234429 0,1312487 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08234429 0,1311578 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08234429 0,13106704 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08234429 0,1309764 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08234429 0,13088588 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08234429 0,13079549 ! male genitalia development GO:0030539 13 11 0,000 0,08234429 0,13070522 ! cholesterol efflux GO:0033344 19 11 0,000 0,08234429 0,13061508 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08234429 0,13052507 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08234429 0,13043517 ! germ cell migration GO:0008354 18 11 0,000 0,08234429 0,1303454 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08234429 0,13025576 ! defense response to fungus GO:0050832 12 11 0,000 0,08234429 0,13016623 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08234429 0,13007683 ! lysogeny GO:0030069 18 11 0,000 0,08234429 0,12998756 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08234429 0,1298984 ! acrosome reaction GO:0007340 13 11 0,000 0,08234429 0,12980937 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08234429 0,12972046 ! neurotransmitter transport GO:0006836 81 62 1,000 0,08400785 0,13225054 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,08400785 0,13216009 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,08400785 0,13206975 ! meiotic cell cycle GO:0051321 97 62 1,000 0,08400785 0,13197954 ! organelle localization GO:0051640 96 62 1,000 0,08400785 0,13188945 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,08633533 0,13545107 GO:0090046|regulation of transcription regulator activity, ! viral reproduction GO:0016032 92 63 1,000 0,08633533 0,13535874 ! regulation of lipase activity GO:0060191 109 63 1,000 0,08633533 0,13526653 ! appendage morphogenesis GO:0035107 93 64 1,000 0,08868217 0,13884887 GO:0035108|limb morphogenesis, ! adaptive immune response GO:0002250 94 64 1,000 0,08868217 0,13875442 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! lactation GO:0007595 20 12 0,000 0,08948762 0,13991947 ! reproductive cellular process GO:0048610 14 12 0,000 0,08948762 0,13982441 ! tRNA modification GO:0006400 14 12 0,000 0,08948762 0,13972949 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08948762 0,13963469 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08948762 0,13954002 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08948762 0,13944549 ! non-recombinational repair GO:0000726 19 12 0,000 0,08948762 0,13935107 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08948762 0,13925679 ! peroxisomal transport GO:0043574 21 12 0,000 0,08948762 0,13916263 ! cartilage condensation GO:0001502 18 12 0,000 0,08948762 0,13906861 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08948762 0,1389747 ! palate development GO:0060021 15 12 0,000 0,08948762 0,13888093 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08948762 0,13878728 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08948762 0,13869376 ! arginine metabolic process GO:0006525 13 12 0,000 0,08948762 0,13860036 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08948762 0,13850709 ! methionine metabolic process GO:0006555 13 12 0,000 0,08948762 0,13841394 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08948762 0,13832092 ! Golgi organization GO:0007030 18 12 0,000 0,08948762 0,13822803 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08948762 0,13813526 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08948762 0,13804261 ! monoamine transport GO:0015844 13 12 0,000 0,08948762 0,13795009 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08948762 0,13785769 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08948762 0,13776542 ! L-amino acid transport GO:0015807 20 12 0,000 0,08948762 0,13767327 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08948762 0,13758124 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08948762 0,13748934 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08948762 0,13739755 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08948762 0,13730589 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08948762 0,13721436 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08948762 0,13712294 ! cerebellum development GO:0021549 13 12 0,000 0,08948762 0,13703165 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08948762 0,13694048 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08948762 0,13684943 ! histone methylation GO:0016571 15 12 0,000 0,08948762 0,1367585 ! gland morphogenesis GO:0022612 23 12 0,000 0,08948762 0,13666769 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08948762 0,136577 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08948762 0,13648643 ! response to gamma radiation GO:0010332 20 12 0,000 0,08948762 0,13639598 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08948762 0,13630565 ! intestinal absorption GO:0050892 19 12 0,000 0,08948762 0,13621544 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08948762 0,13612535 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08948762 0,13603538 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08948762 0,13594553 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08948762 0,1358558 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08948762 0,13576618 ! microspike assembly GO:0030035 23 12 0,000 0,08948762 0,13567669 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08948762 0,13558731 ! response to cold GO:0009409 14 12 0,000 0,08948762 0,13549805 ! regulation of caspase activity GO:0043281 97 65 1,000 0,09104792 0,13776987 ! appendage development GO:0048736 94 65 1,000 0,09104792 0,13767929 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,09104792 0,13758884 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,09104792 0,13749849 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,09104792 0,13740827 ! protein oligomerization GO:0051259 100 65 1,000 0,09104792 0,13731817 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,09343214 0,14082171 ! regulation of immune effector process GO:0002697 101 66 1,000 0,09343214 0,14072949 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,09583442 0,14425338 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09657576 0,14527419 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09657576 0,14517924 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09657576 0,14508442 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,09657576 0,14498971 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09657576 0,14489514 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09657576 0,14480068 ! lipid localization GO:0010876 24 13 0,000 0,09657576 0,14470635 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09657576 0,14461214 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09657576 0,14451805 ! organelle fusion GO:0048284 28 13 0,000 0,09657576 0,14442408 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09657576 0,14433024 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09657576 0,14423652 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09657576 0,14414292 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09657576 0,14404944 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,09657576 0,14395609 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09657576 0,14386285 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09657576 0,14376974 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09657576 0,14367674 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! NAD metabolic process GO:0019674 21 13 0,000 0,09657576 0,14358387 ! exocrine system development GO:0035272 27 13 0,000 0,09657576 0,14349111 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09657576 0,14339848 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09657576 0,14330596 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09657576 0,14321357 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09657576 0,14312129 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09657576 0,14302913 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09657576 0,14293709 ! genitalia development GO:0048806 15 13 0,000 0,09657576 0,14284517 ! regulation of cellular pH GO:0030641 20 13 0,000 0,09657576 0,14275337 ! cellular pigmentation GO:0033059 24 13 0,000 0,09657576 0,14266168 ! tissue regeneration GO:0042246 21 13 0,000 0,09657576 0,14257012 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09657576 0,14247867 ! cofactor transport GO:0051181 19 13 0,000 0,09657576 0,14238733 ! NADP metabolic process GO:0006739 18 13 0,000 0,09657576 0,14229612 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09657576 0,14220502 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09657576 0,14211404 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09657576 0,14202317 ! gas transport GO:0015669 18 13 0,000 0,09657576 0,14193242 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09657576 0,14184179 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09657576 0,14175127 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09657576 0,14166087 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09657576 0,14157058 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09657576 0,14148041 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09657576 0,14139035 ! acute inflammatory response GO:0002526 92 68 1,000 0,09825433 0,14375634 ! response to drug GO:0042493 108 69 1,000 0,10069146 0,14722846 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,10069146 0,14713492 ! humoral immune response GO:0006959 86 70 1,000 0,10314541 0,15062504 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,10314541 0,15052946 ! superoxide anion generation GO:0042554 18 14 0,000 0,10360911 0,15111031 ! neuron maturation GO:0042551 21 14 0,000 0,10360911 0,15101455 ! regulation of S phase GO:0033261 18 14 0,000 0,10360911 0,15091891 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10360911 0,15082339 ! myotube differentiation GO:0014902 21 14 0,000 0,10360911 0,150728 ! inositol metabolic process GO:0006020 20 14 0,000 0,10360911 0,15063272 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10360911 0,15053756 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10360911 0,15044253 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10360911 0,15034761 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10360911 0,15025281 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10360911 0,15015814 ! response to cAMP GO:0051591 19 14 0,000 0,10360911 0,15006358 ! limbic system development GO:0021761 25 14 0,000 0,10360911 0,14996914 ! startle response GO:0001964 21 14 0,000 0,10360911 0,14987482 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10360911 0,14978062 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10360911 0,14968653 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,10360911 0,14959257 ! glycine metabolic process GO:0006544 22 14 0,000 0,10360911 0,14949872 ! pituitary gland development GO:0021983 23 14 0,000 0,10360911 0,14940499 ! cellular response to starvation GO:0009267 21 14 0,000 0,10360911 0,14931138 ! lysosomal transport GO:0007041 20 14 0,000 0,10360911 0,14921788 ! regulation of heart rate GO:0002027 23 14 0,000 0,10360911 0,14912451 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10360911 0,14903125 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10360911 0,1489381 ! embryo implantation GO:0007566 27 14 0,000 0,10360911 0,14884507 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,10360911 0,14875216 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,10360911 0,14865936 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10360911 0,14856668 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,10360911 0,14847412 ! axon cargo transport GO:0008088 27 14 0,000 0,10360911 0,14838167 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,10360911 0,14828933 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,10360911 0,14819712 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,10360911 0,14810501 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10360911 0,14801302 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10360911 0,14792114 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10360911 0,14782938 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10360911 0,14773773 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10360911 0,1476462 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10360911 0,14755477 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10360911 0,14746347 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10360911 0,14737227 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,10360911 0,14728119 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10360911 0,14719022 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10360911 0,14709936 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10360911 0,14700861 ! cell killing GO:0001906 20 14 0,000 0,10360911 0,14691798 ! cilium assembly GO:0042384 20 14 0,000 0,10360911 0,14682746 ! peptide hormone secretion GO:0030072 23 14 0,000 0,10360911 0,14673704 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,10561575 0,14948691 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,10810211 0,15291196 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,10810211 0,15281797 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,11058811 0,15623628 ! positive regulation of cell size GO:0045793 20 15 0,000 0,11058811 0,15614037 ! metencephalon development GO:0022037 19 15 0,000 0,11058811 0,15604458 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,11058811 0,1559489 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,11058811 0,15585335 ! skin development GO:0043588 25 15 0,000 0,11058811 0,15575791 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,11058811 0,15566258 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,11058811 0,15556738 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,11058811 0,15547229 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,11058811 0,15537731 ! bile acid metabolic process GO:0008206 22 15 0,000 0,11058811 0,15528245 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,11058811 0,15518771 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,11058811 0,15509309 ! adult walking behavior GO:0007628 25 15 0,000 0,11058811 0,15499857 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,11058811 0,15490418 ! myoblast differentiation GO:0045445 27 15 0,000 0,11058811 0,1548099 ! centrosome cycle GO:0007098 16 15 0,000 0,11058811 0,15471573 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,11058811 0,15462168 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,11058811 0,15452774 ! response to osmotic stress GO:0006970 22 15 0,000 0,11058811 0,15443392 ! vesicle coating GO:0006901 25 15 0,000 0,11058811 0,15434021 ! DNA integration GO:0015074 22 15 0,000 0,11058811 0,15424661 ! peptide secretion GO:0002790 27 15 0,000 0,11058811 0,15415313 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,11058811 0,15405976 ! regulation of vasodilation GO:0042312 24 15 0,000 0,11058811 0,1539665 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,11058811 0,15387336 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,11058811 0,15378033 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,11058811 0,15368741 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,11058811 0,1535946 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,11058811 0,15350191 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,11058811 0,15340932 ! dopamine metabolic process GO:0042417 30 15 0,000 0,11058811 0,15331685 ! organic cation transport GO:0015695 19 15 0,000 0,11058811 0,15322449 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,11058811 0,15313225 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,11058811 0,15304011 ! defense response to virus GO:0051607 27 15 0,000 0,11058811 0,15294808 ! peptide hormone processing GO:0016486 19 15 0,000 0,11058811 0,15285617 ! tube morphogenesis GO:0035239 118 73 1,000 0,11060407 0,15278641 ! hormone secretion GO:0046879 25 16 0,000 0,11751317 0,16223307 ! bone remodeling GO:0046849 24 16 0,000 0,11751317 0,16213575 ! endothelial cell migration GO:0043542 22 16 0,000 0,11751317 0,16203855 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11751317 0,16194146 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11751317 0,16184449 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11751317 0,16174763 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11751317 0,1616509 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11751317 0,16155427 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11751317 0,16145776 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11751317 0,16136137 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11751317 0,16126509 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11751317 0,16116893 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11751317 0,16107288 ! fructose metabolic process GO:0006000 20 16 0,000 0,11751317 0,16097695 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11751317 0,16088113 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11751317 0,16078542 ! protein export from nucleus GO:0006611 24 16 0,000 0,11751317 0,16068983 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11751317 0,16059435 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11751317 0,16049899 ! DNA replication initiation GO:0006270 25 16 0,000 0,11751317 0,16040374 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11751317 0,1603086 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11751317 0,16021357 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11751317 0,16011866 ! diencephalon development GO:0021536 25 16 0,000 0,11751317 0,16002386 ! oogenesis GO:0048477 23 16 0,000 0,11751317 0,15992917 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11751317 0,15983459 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11751317 0,15974013 ! steroid catabolic process GO:0006706 22 16 0,000 0,11751317 0,15964577 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11751317 0,15955153 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11751317 0,1594574 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11751317 0,15936338 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11751317 0,15926947 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11751317 0,15917568 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11751317 0,15908199 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11751317 0,15898841 ! tRNA metabolic process GO:0006399 95 76 1,000 0,11819978 0,15982334 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,12076036 0,16318968 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,12076036 0,16309386 ! regulation of DNA binding GO:0051101 119 77 1,000 0,12076036 0,16299814 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,12076036 0,16290254 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,12076036 0,16280706 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,12333466 0,16618027 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12438471 0,16749697 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,12438471 0,16739896 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12438471 0,16730107 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,12438471 0,16720329 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12438471 0,16710562 ! glycerol metabolic process GO:0006071 20 17 0,000 0,12438471 0,16700807 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,12438471 0,16691063 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,12438471 0,16681331 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12438471 0,1667161 ! signal complex assembly GO:0007172 29 17 0,000 0,12438471 0,166619 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12438471 0,16652202 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,12438471 0,16642514 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12438471 0,16632839 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,12438471 0,16623174 ! keratinization GO:0031424 17 17 0,000 0,12438471 0,16613521 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12438471 0,16603878 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,12438471 0,16594247 ! retinoid metabolic process GO:0001523 22 17 0,000 0,12438471 0,16584627 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12438471 0,16575019 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12438471 0,16565421 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12438471 0,16555835 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12438471 0,16546259 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,12438471 0,16536695 ! membrane budding GO:0006900 29 17 0,000 0,12438471 0,16527142 ! heme metabolic process GO:0042168 27 17 0,000 0,12438471 0,165176 ! actin filament bundle formation GO:0051017 26 17 0,000 0,12438471 0,16508068 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,12438471 0,16498548 ! body fluid secretion GO:0007589 27 17 0,000 0,12438471 0,16489039 ! stem cell differentiation GO:0048863 36 17 0,000 0,12438471 0,16479541 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12438471 0,16470053 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12438471 0,16460577 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12438471 0,16451111 ! sensory perception of pain GO:0019233 23 17 0,000 0,12438471 0,16441657 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,12438471 0,16432213 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12438471 0,1642278 ! synaptogenesis GO:0007416 24 17 0,000 0,12438471 0,16413358 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12438471 0,16403946 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,12438471 0,16394546 ! cell-cell junction organization GO:0045216 25 17 0,000 0,12438471 0,16385156 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,12438471 0,16375777 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12438471 0,16366409 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,12438471 0,16357051 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,12592231 0,1654979 ! regulation of lyase activity GO:0051339 133 79 1,000 0,12592231 0,16540338 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,13113625 0,17215375 ! regulation of neurological system process GO:0031644 122 81 1,000 0,13113625 0,17205555 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,13120312 0,17204515 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,13120312 0,17194712 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13120312 0,1718492 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13120312 0,17175139 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13120312 0,17165369 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13120312 0,1715561 ! axis specification GO:0009798 26 18 0,000 0,13120312 0,17145863 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13120312 0,17136126 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,13120312 0,17126401 ! pancreas development GO:0031016 26 18 0,000 0,13120312 0,17116687 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13120312 0,17106983 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13120312 0,17097291 ! pigmentation during development GO:0048066 31 18 0,000 0,13120312 0,1708761 ! central nervous system neuron development GO:0021954 30 18 0,000 0,13120312 0,17077939 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13120312 0,1706828 ! fucose metabolic process GO:0006004 26 18 0,000 0,13120312 0,17058631 ! response to fungus GO:0009620 19 18 0,000 0,13120312 0,17048994 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,13120312 0,17039367 ! heart process GO:0003015 27 18 0,000 0,13120312 0,17029751 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,13120312 0,17020146 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,13120312 0,17010552 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13120312 0,17000968 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13120312 0,16991396 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,13120312 0,16981834 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,13120312 0,16972283 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13120312 0,16962742 ! vitamin transport GO:0051180 24 18 0,000 0,13120312 0,16953213 ! hormone transport GO:0009914 27 18 0,000 0,13120312 0,16943694 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,13120312 0,16934186 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,13120312 0,16924688 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13120312 0,16915201 ! cell-cell recognition GO:0009988 20 18 0,000 0,13120312 0,16905725 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13120312 0,16896259 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13120312 0,16886804 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,13120312 0,16877359 ! detection of stimulus GO:0051606 108 82 1,000 0,13376183 0,17196881 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,13639935 0,17526174 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13796884 0,17717941 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13796884 0,17708054 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13796884 0,17698177 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13796884 0,17688312 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,13796884 0,17678458 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13796884 0,17668615 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13796884 0,17658783 ! regeneration GO:0031099 32 19 0,000 0,13796884 0,17648961 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13796884 0,17639151 ! sensory perception of taste GO:0050909 23 19 0,000 0,13796884 0,17629351 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13796884 0,17619563 ! peroxisome organization GO:0007031 29 19 0,000 0,13796884 0,17609785 ! digestive system process GO:0022600 30 19 0,000 0,13796884 0,17600018 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13796884 0,17590262 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13796884 0,17580516 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13796884 0,17570782 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13796884 0,17561058 ! response to starvation GO:0042594 30 19 0,000 0,13796884 0,17551345 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13796884 0,17541643 ! cytolysis GO:0019835 20 19 0,000 0,13796884 0,17531951 ! renal system process GO:0003014 35 19 0,000 0,13796884 0,17522271 ! vasodilation GO:0042311 33 19 0,000 0,13796884 0,17512601 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13796884 0,17502941 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13796884 0,17493292 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13796884 0,17483654 ! sarcomere organization GO:0045214 23 19 0,000 0,13796884 0,17474027 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13796884 0,1746441 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13796884 0,17454803 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13796884 0,17445207 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13796884 0,17435622 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13796884 0,17426047 ! protein stabilization GO:0050821 26 19 0,000 0,13796884 0,17416483 ! sterol metabolic process GO:0016125 120 84 1,000 0,13904848 0,17543144 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,14170888 0,17868992 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,14170888 0,17859201 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,14438021 0,18185897 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,14468224 0,18213966 ! iron ion transport GO:0006826 37 20 0,000 0,14468224 0,18204002 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,14468224 0,18194049 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,14468224 0,18184107 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,14468224 0,18174176 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,14468224 0,18164255 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,14468224 0,18154346 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,14468224 0,18144447 ! response to ethanol GO:0045471 37 20 0,000 0,14468224 0,18134559 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,14468224 0,18124682 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,14468224 0,18114815 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,14468224 0,1810496 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,14468224 0,18095115 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,14468224 0,1808528 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,14468224 0,18075457 ! DNA modification GO:0006304 28 20 0,000 0,14468224 0,18065644 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,14468224 0,18055842 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,14468224 0,1804605 ! collagen catabolic process GO:0030574 25 20 0,000 0,14468224 0,18036269 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,14468224 0,18026498 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,14468224 0,18016738 ! alditol metabolic process GO:0019400 24 20 0,000 0,14468224 0,18006989 ! actin filament-based movement GO:0030048 34 20 0,000 0,14468224 0,1799725 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,14706215 0,18283402 ! protein processing GO:0016485 114 88 1,000 0,14975437 0,18608053 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,15134375 0,1879539 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,15134375 0,18785247 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,15134375 0,18775115 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,15134375 0,18764993 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,15134375 0,18754883 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,15134375 0,18744783 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,15134375 0,18734694 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,15134375 0,18724617 ! vesicle docking GO:0048278 27 21 0,000 0,15134375 0,1871455 ! phototransduction GO:0007602 25 21 0,000 0,15134375 0,18704493 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,15134375 0,18694448 ! ovarian follicle development GO:0001541 30 21 0,000 0,15134375 0,18684413 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,15134375 0,1867439 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,15134375 0,18664377 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,15134375 0,18654374 ! cell aging GO:0007569 32 21 0,000 0,15134375 0,18644383 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,15134375 0,18634402 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,15134375 0,18624431 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,15134375 0,18614472 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,15134375 0,18604523 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,15134375 0,18594585 GO:0060415|muscle tissue morphogenesis, ! leukotriene metabolic process GO:0006691 28 21 0,000 0,15134375 0,18584657 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,15134375 0,1857474 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,15134375 0,18564833 ! fatty acid transport GO:0015908 30 21 0,000 0,15134375 0,18554937 ! immunoglobulin production GO:0002377 33 21 0,000 0,15134375 0,18545052 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,15134375 0,18535177 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,15134375 0,18525313 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,15134375 0,18515459 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,15134375 0,18505615 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,15134375 0,18495782 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,15134375 0,1848596 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,15134375 0,18476148 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,15134375 0,18466346 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,15134375 0,18456555 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,15134375 0,18446774 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,15134375 0,18437003 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,15134375 0,18427243 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,15134375 0,18417493 GO:0006099|tricarboxylic acid cycle, ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,15245656 0,18543104 ! viral genome replication GO:0019079 29 22 0,000 0,15795375 0,19201566 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15795375 0,19191423 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15795375 0,1918129 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15795375 0,19171168 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,15795375 0,19161056 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,15795375 0,19150956 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15795375 0,19140866 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15795375 0,19130786 ! lysosome organization GO:0007040 37 22 0,000 0,15795375 0,19120717 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15795375 0,19110659 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15795375 0,19100611 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15795375 0,19090574 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15795375 0,19080548 ! membrane depolarization GO:0051899 35 22 0,000 0,15795375 0,19070532 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15795375 0,19060526 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15795375 0,19050531 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15795375 0,19040547 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15795375 0,19030572 ! blastocyst development GO:0001824 37 22 0,000 0,15795375 0,19020609 ! neural tube closure GO:0001843 33 22 0,000 0,15795375 0,19010656 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,15795375 0,19000713 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,16061981 0,19311321 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,16335876 0,19630363 ! embryonic pattern specification GO:0009880 31 23 0,000 0,16451265 0,19758699 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,16451265 0,19748386 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,16451265 0,19738085 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,16451265 0,19727794 ! vesicle targeting GO:0006903 32 23 0,000 0,16451265 0,19717514 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,16451265 0,19707244 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,16451265 0,19696985 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,16451265 0,19686737 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,16451265 0,19676499 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,16451265 0,19666273 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16451265 0,19656056 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16451265 0,19645851 ! cell fate determination GO:0001709 45 23 0,000 0,16451265 0,19635656 ! pentose metabolic process GO:0019321 31 23 0,000 0,16451265 0,19625471 ! spermatid development GO:0007286 33 23 0,000 0,16451265 0,19615297 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16451265 0,19605134 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,16451265 0,19594981 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16451265 0,19584839 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,16451265 0,19574707 ! telomere organization GO:0032200 32 23 0,000 0,16451265 0,19564586 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,16451265 0,19554475 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16451265 0,19544374 ! regulation of amine transport GO:0051952 38 23 0,000 0,16451265 0,19534284 ! response to oxidative stress GO:0006979 141 94 1,000 0,16610615 0,1971332 ! initiation of viral infection GO:0019059 42 24 0,000 0,17102082 0,20286121 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,17102082 0,20275665 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,17102082 0,20265219 ! superoxide metabolic process GO:0006801 32 24 0,000 0,17102082 0,20254783 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,17102082 0,20244359 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,17102082 0,20233945 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,17102082 0,20223542 ! sperm motility GO:0030317 27 24 0,000 0,17102082 0,2021315 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,17102082 0,20202768 ! vacuole organization GO:0007033 39 24 0,000 0,17102082 0,20192397 ! receptor metabolic process GO:0043112 37 24 0,000 0,17102082 0,20182037 ! response to toxin GO:0009636 38 24 0,000 0,17102082 0,20171687 ! primary neural tube formation GO:0014020 35 24 0,000 0,17102082 0,20161348 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,17102082 0,20151019 ! base-excision repair GO:0006284 31 24 0,000 0,17102082 0,20140701 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,17102082 0,20130394 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,17102082 0,20120097 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,17102082 0,20109811 ! in utero embryonic development GO:0001701 147 96 1,000 0,17162506 0,20170549 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,17162506 0,20160247 ! protein maturation GO:0051604 129 96 1,000 0,17162506 0,20149956 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17747867 0,20826579 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17747867 0,20815959 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17747867 0,20805349 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17747867 0,2079475 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,17747867 0,20784163 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17747867 0,20773585 ! peptide transport GO:0015833 43 25 0,000 0,17747867 0,20763019 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,17747867 0,20752463 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17747867 0,20741918 ! phospholipid transport GO:0015914 35 25 0,000 0,17747867 0,20731384 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17747867 0,20720861 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17747867 0,20710348 ! detection of light stimulus GO:0009583 30 25 0,000 0,17747867 0,20699845 ! leukocyte proliferation GO:0070661 39 25 0,000 0,17747867 0,20689354 GO:0032943|mononuclear cell proliferation, ! homophilic cell adhesion GO:0007156 149 100 1,000 0,18275144 0,21293228 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,18275144 0,21282447 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,18388659 0,21403803 ! translational initiation GO:0006413 43 26 0,000 0,18388659 0,21392977 ! regulation of pH GO:0006885 36 26 0,000 0,18388659 0,21382161 ! circadian rhythm GO:0007623 42 26 0,000 0,18388659 0,21371357 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,18388659 0,21360563 ! post-embryonic development GO:0009791 42 26 0,000 0,18388659 0,2134978 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,18388659 0,21339008 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,18388659 0,21328247 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,18388659 0,21317497 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,18388659 0,21306758 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,18388659 0,2129603 ! regulation of coagulation GO:0050818 39 26 0,000 0,18388659 0,21285312 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,19024494 0,22010229 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,19024494 0,21999163 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,19024494 0,21988109 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,19024494 0,21977065 ! membrane docking GO:0022406 39 27 0,000 0,19024494 0,21966032 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,19024494 0,21955011 ! catechol metabolic process GO:0009712 43 27 0,000 0,19024494 0,21944 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,19024494 0,21933001 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,19024494 0,21922012 ! myofibril assembly GO:0030239 36 27 0,000 0,19024494 0,21911035 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,19024494 0,21900068 ! response to ionizing radiation GO:0010212 47 27 0,000 0,19024494 0,21889113 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,19024494 0,21878168 ! natural killer cell activation GO:0030101 35 27 0,000 0,19024494 0,21867234 ! lipid oxidation GO:0034440 38 27 0,000 0,19024494 0,21856312 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,19024494 0,218454 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,19024494 0,21834499 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,19024494 0,21823609 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,19024494 0,2181273 ! gene silencing GO:0016458 41 27 0,000 0,19024494 0,21801862 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,19655412 0,22513669 ! phenol metabolic process GO:0018958 44 28 0,000 0,19655412 0,22502462 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,19655412 0,22491267 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,19655412 0,22480083 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,19655412 0,2246891 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,19655412 0,22457748 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,19655412 0,22446597 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,19655412 0,22435457 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,19655412 0,22424329 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,19655412 0,22413211 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,19655412 0,22402104 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,19655412 0,22391009 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,19655412 0,22379924 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,19655412 0,2236885 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,19655412 0,22357788 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,19655412 0,22346736 ! BMP signaling pathway GO:0030509 40 28 0,000 0,19655412 0,22335695 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,19655412 0,22324665 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,19655412 0,22313646 ! neural tube formation GO:0001841 41 28 0,000 0,19655412 0,22302638 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,20281449 0,23001644 ! regulation of innate immune response GO:0045088 38 29 0,000 0,20281449 0,22990307 ! ovulation cycle process GO:0022602 41 29 0,000 0,20281449 0,22978982 ! protein targeting to membrane GO:0006612 53 29 0,000 0,20281449 0,22967668 ! mismatch repair GO:0006298 34 29 0,000 0,20281449 0,22956365 ! muscle cell development GO:0055001 38 29 0,000 0,20281449 0,22945073 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,20281449 0,22933792 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,20281449 0,22922523 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20902645 0,23613007 ! organic anion transport GO:0015711 51 30 0,000 0,20902645 0,23601415 ! cholesterol transport GO:0030301 46 30 0,000 0,20902645 0,23589835 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,20902645 0,23578265 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20902645 0,23566707 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20902645 0,23555161 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20902645 0,23543625 ! ovulation cycle GO:0042698 43 30 0,000 0,20902645 0,23532101 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20902645 0,23520589 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20902645 0,23509087 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,20902645 0,23497597 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,20902645 0,23486118 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,20902645 0,2347465 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,21519035 0,24155091 ! negative regulation of secretion GO:0051048 49 31 0,000 0,21519035 0,24143308 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,21519035 0,24131536 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,21519035 0,24119776 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,21519035 0,24108027 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,21519035 0,2409629 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,21519035 0,24084565 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,21519035 0,2407285 ! RNA modification GO:0009451 40 31 0,000 0,21519035 0,24061148 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,22130657 0,24732998 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,22130657 0,24720986 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,22130657 0,24708986 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,22130657 0,24696997 ! regulation of protein stability GO:0031647 48 32 0,000 0,22130657 0,2468502 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,22130657 0,24673054 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,22130657 0,246611 ! vesicle localization GO:0051648 47 32 0,000 0,22130657 0,24649158 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,22737547 0,25312855 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,22737547 0,25300608 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,22737547 0,25288374 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,22737547 0,25276152 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,22737547 0,25263941 ! actomyosin structure organization GO:0031032 43 33 0,000 0,22737547 0,25251742 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,22737547 0,25239555 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,22737547 0,25227379 ! female gonad development GO:0008585 49 33 0,000 0,22737547 0,25215216 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,22737547 0,25203064 ! lipid homeostasis GO:0055088 55 33 0,000 0,22737547 0,25190924 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,22737547 0,25178795 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,22737547 0,25166678 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,22737547 0,25154573 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,22737547 0,2514248 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,22737547 0,25130398 ! mRNA catabolic process GO:0006402 48 34 0,000 0,23339741 0,25783576 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,23339741 0,25771198 ! feeding behavior GO:0007631 45 34 0,000 0,23339741 0,25758832 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,23339741 0,25746477 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,23339741 0,25734135 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,23339741 0,25721804 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,23339741 0,25709485 ! female gamete generation GO:0007292 43 34 0,000 0,23339741 0,25697178 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,23339741 0,25684883 ! polyol metabolic process GO:0019751 44 34 0,000 0,23339741 0,25672599 ! aerobic respiration GO:0009060 47 34 0,000 0,23339741 0,25660327 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,23937277 0,263047 ! Notch signaling pathway GO:0007219 56 35 0,000 0,23937277 0,26292138 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,23937277 0,26279588 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,23937277 0,2626705 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,23937277 0,26254524 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,23937277 0,2624201 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,23937277 0,26229507 ! pigment metabolic process GO:0042440 61 35 0,000 0,23937277 0,26217017 ! protein homooligomerization GO:0051260 52 35 0,000 0,23937277 0,26204539 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,24530188 0,26840834 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,24530188 0,26828071 ! negative regulation of binding GO:0051100 58 36 0,000 0,24530188 0,2681532 ! organic ether metabolic process GO:0018904 46 36 0,000 0,24530188 0,26802581 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,24530188 0,26789854 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,24530188 0,2677714 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,24530188 0,26764437 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,24530188 0,26751746 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,25118512 0,27380368 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,25118512 0,27367398 ! ion transmembrane transport GO:0034220 56 37 0,000 0,25118512 0,2735444 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,25118512 0,27341494 ! regulation of protein secretion GO:0050708 51 37 0,000 0,25118512 0,27328561 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,25118512 0,27315639 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,25702283 0,27937264 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,25702283 0,27924067 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,25702283 0,27910883 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,25702283 0,27897711 ! phagocytosis GO:0006909 60 38 0,000 0,25702283 0,27884552 ! maintenance of location in cell GO:0051651 69 38 0,000 0,25702283 0,27871405 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,26281536 0,28486113 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,26281536 0,28472695 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,26281536 0,2845929 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,26281536 0,28445898 ! chromatin remodeling GO:0006338 68 39 0,000 0,26281536 0,28432518 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,26281536 0,2841915 ! JNK cascade GO:0007254 54 39 0,000 0,26281536 0,28405795 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,26856306 0,29013388 ! response to calcium ion GO:0051592 58 40 0,000 0,26856306 0,28999767 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,26856306 0,28986158 ! regulation of tube size GO:0035150 60 40 0,000 0,26856306 0,28972562 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,26856306 0,28958979 ! inner ear development GO:0048839 57 40 0,000 0,26856306 0,28945409 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,26856306 0,28931852 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,26856306 0,28918307 ! B cell differentiation GO:0030183 62 40 0,000 0,26856306 0,28904774 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,27426627 0,2950479 ! endosome transport GO:0016197 71 41 0,000 0,27426627 0,29490997 ! striated muscle contraction GO:0006941 62 41 0,000 0,27426627 0,29477216 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,27426627 0,29463448 ! biopolymer methylation GO:0043414 62 41 0,000 0,27426627 0,29449693 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,27426627 0,2943595 ! mitochondrial transport GO:0006839 60 42 0,000 0,27992534 0,30029304 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,27992534 0,30015304 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,27992534 0,30001317 ! excretion GO:0007588 63 42 0,000 0,27992534 0,29987344 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,27992534 0,29973383 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,27992534 0,29959436 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,27992534 0,29945501 ! neuromuscular process GO:0050905 79 43 0,000 0,2855406 0,30532002 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,2855406 0,30517815 ! tRNA processing GO:0008033 49 43 0,000 0,2855406 0,3050364 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,2855406 0,30489479 ! vesicle organization GO:0016050 79 43 0,000 0,2855406 0,30475331 ! methylation GO:0032259 64 43 0,000 0,2855406 0,30461195 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,29111239 0,31041191 ! glycolysis GO:0006096 53 44 0,000 0,29111239 0,31026807 ! regulation of ion transport GO:0043269 57 44 0,000 0,29111239 0,31012436 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,29111239 0,30998078 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,29111239 0,30983734 ! RNA catabolic process GO:0006401 64 45 0,000 0,29664105 0,31557558 ! regulation of translational initiation GO:0006446 64 45 0,000 0,29664105 0,31542968 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,29664105 0,31528392 ! cell maturation GO:0048469 60 45 0,000 0,29664105 0,31513829 ! cell redox homeostasis GO:0045454 63 46 0,000 0,3021269 0,32081804 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,3021269 0,32066999 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,3021269 0,32052208 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,30757028 0,32614644 ! viral infectious cycle GO:0019058 71 47 0,000 0,30757028 0,32599615 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,30757028 0,32584599 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,30757028 0,32569597 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,30757028 0,32554608 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,30757028 0,32539634 ! chloride transport GO:0006821 67 48 0,000 0,31297151 0,33095837 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,31297151 0,33080628 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,31297151 0,33065432 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 0,000 0,31297151 0,33050251 ! nuclear export GO:0051168 69 48 0,000 0,31297151 0,33035083 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,31833091 0,33585371 ! sensory perception of smell GO:0007608 61 49 0,000 0,31833091 0,33569972 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,31833091 0,33554587 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,31833091 0,33539217 ! RNA elongation GO:0006354 62 49 0,000 0,31833091 0,3352386 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,31833091 0,33508517 ! maintenance of location GO:0051235 84 49 0,000 0,31833091 0,33493188 ! regulation of actin filament length GO:0030832 72 50 0,000 0,32364881 0,34037141 ! proton transport GO:0015992 75 50 0,000 0,32364881 0,34021585 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,32364881 0,34006043 ! positive regulation of secretion GO:0051047 71 51 0,000 0,32892553 0,34544691 ! hydrogen transport GO:0006818 77 51 0,000 0,32892553 0,34528924 ! adult behavior GO:0030534 80 51 0,000 0,32892553 0,34513172 ! transition metal ion transport GO:0000041 74 52 0,000 0,33416138 0,35046566 ! regulation of cellular component size GO:0032535 74 52 0,000 0,33416138 0,35030592 ! aging GO:0007568 79 52 0,000 0,33416138 0,35014633 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,33416138 0,34998688 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,33416138 0,34982758 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,33935668 0,35510481 ! single fertilization GO:0007338 59 53 0,000 0,33935668 0,35494333 ! amino acid transport GO:0006865 84 54 0,000 0,34451174 0,36017137 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,34451174 0,36000773 ! glucose catabolic process GO:0006007 66 54 0,000 0,34451174 0,35984423 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,34451174 0,35968089 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,34962687 0,36485562 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,34962687 0,36469015 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,35470237 0,36981661 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,35470237 0,36964905 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,35973855 0,37472765 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,35973855 0,37455802 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,35973855 0,37438853 ! secondary metabolic process GO:0019748 84 57 0,000 0,35973855 0,3742192 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,36473571 0,37924599 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,36473571 0,37907462 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,36969415 0,38405445 ! actin filament organization GO:0007015 95 59 0,000 0,36969415 0,38388106 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,36969415 0,38370783 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,36969415 0,38353476 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,37461418 0,38846376 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,37461418 0,38828869 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,37461418 0,38811379 ! fertilization GO:0009566 68 60 0,000 0,37461418 0,38793904 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,37949608 0,39281772 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,37949608 0,39264102 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,37949608 0,39246447 ! amine catabolic process GO:0009310 90 62 0,000 0,38434015 0,39729543 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,38434015 0,39711696 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,38434015 0,39693864 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,38914668 0,40172233 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,38914668 0,40154211 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,39391596 0,40628103 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,39391596 0,40609892 ! hexose catabolic process GO:0019320 82 64 0,000 0,39391596 0,40591698 ! B cell activation GO:0042113 104 65 0,000 0,39864827 0,4106095 ! defense response to bacterium GO:0042742 73 65 0,000 0,39864827 0,4104257 ! activation of immune response GO:0002253 83 65 0,000 0,39864827 0,41024207 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,4033439 0,41488863 ! antigen processing and presentation GO:0019882 96 66 0,000 0,4033439 0,41470316 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,4033439 0,41451786 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,40800314 0,4191189 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,41262625 0,42367874 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,41262625 0,42348968 ! rhythmic process GO:0048511 105 68 0,000 0,41262625 0,42330079 ! inorganic anion transport GO:0015698 93 68 0,000 0,41262625 0,42311207 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,41721353 0,42762528 ! response to metal ion GO:0010038 103 70 0,000 0,42176524 0,43209802 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,42176524 0,43190563 ! amine transport GO:0015837 101 70 0,000 0,42176524 0,43171342 ! muscle cell differentiation GO:0042692 104 71 0,000 0,42628166 0,43614227 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,42628166 0,43594834 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,42628166 0,43575459 ! regulation of blood pressure GO:0008217 107 73 0,000 0,43520972 0,44468341 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,43520972 0,44448595 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,43520972 0,44428866 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,43962189 0,44859376 ! digestion GO:0007586 97 74 0,000 0,43962189 0,44839483 ! blood coagulation GO:0007596 116 75 0,000 0,44399984 0,45265941 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,44399984 0,45245886 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,44399984 0,45225848 ! amine biosynthetic process GO:0009309 97 76 0,000 0,44834384 0,45648111 ! response to unfolded protein GO:0006986 99 76 0,000 0,44834384 0,45627913 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,45265415 0,46046199 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,45693103 0,46460715 ! cellular respiration GO:0045333 107 79 0,000 0,46117473 0,46871493 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,46117473 0,4685079 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,46117473 0,46830105 ! chromatin assembly GO:0031497 102 80 0,000 0,46538551 0,47236835 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,46538551 0,47215998 ! hemostasis GO:0007599 125 81 0,000 0,46956363 0,47618886 ! mRNA transport GO:0051028 121 81 0,000 0,46956363 0,475979 ! response to protein stimulus GO:0051789 111 81 0,000 0,46956363 0,47576931 ! vitamin metabolic process GO:0006766 103 81 0,000 0,46956363 0,47555982 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,47782286 0,48371153 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,48190448 0,48762882 ! rRNA metabolic process GO:0016072 107 85 0,000 0,48595443 0,49151064 GO:0006364|rRNA processing, ! nucleosome organization GO:0034728 114 87 0,000 0,49396029 0,49938842 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,49396029 0,49916901 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,49396029 0,49894978 ! female pregnancy GO:0007565 130 87 0,000 0,49396029 0,49873075 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,49791668 0,50250476 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,49791668 0,50228437 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,49791668 0,50206416 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,50184236 0,5058008 ! hormone metabolic process GO:0042445 121 90 0,000 0,50573757 0,50950347 ! RNA localization GO:0006403 135 91 0,000 0,50960255 0,51317245 ! ATP metabolic process GO:0046034 137 91 0,000 0,50960255 0,51294786 ! response to virus GO:0009615 122 91 0,000 0,50960255 0,51272348 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,51343753 0,51635606 ! positive regulation of immune response GO:0050778 121 92 0,000 0,51343753 0,51613038 ! DNA recombination GO:0006310 146 92 0,000 0,51343753 0,5159049 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,51724273 0,51950143 ! electron transport chain GO:0022900 123 94 0,000 0,52101839 0,52306517 ! carboxylic acid transport GO:0046942 147 95 0,000 0,52476474 0,52659638 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,528482 0,53009533 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,5321704 0,5335623 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,5321704 0,53332981 ! calcium ion transport GO:0006816 167 99 0,000 0,53946148 0,54040131 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,54306461 0,54377388 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,54306461 0,54353726 ! divalent metal ion transport GO:0070838 171 100 0,000 0,54306461 0,54330083 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,54306461 0,54306461