pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6932-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! phosphoinositide 3-kinase cascade GO:0014065 32 8 3,000 7,23E-08 1,74E-04 ! induction of positive chemotaxis GO:0050930 15 9 3,000 1,296E-07 1,559E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 3,000 1,296E-07 1,039E-04 ! negative regulation of phosphorylation GO:0042326 47 24 4,000 2,296E-07 1,381E-04 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 3,000 3,363E-07 1,618E-04 ! insulin receptor signaling pathway GO:0008286 64 26 4,000 3,521E-07 1,412E-04 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 4,000 3,521E-07 1,21E-04 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of phosphorylation GO:0042327 129 79 6,000 3,74E-07 1,125E-04 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 6,000 4,443E-07 1,188E-04 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of cellular catabolic process GO:0031331 31 12 3,000 5,022E-07 1,208E-04 ! regulation of positive chemotaxis GO:0050926 19 12 3,000 5,022E-07 1,098E-04 GO:0050927|positive regulation of positive chemotaxis, ! regulation of angiogenesis GO:0045765 114 52 5,000 5,386E-07 1,08E-04 ! regulation of monooxygenase activity GO:0032768 33 13 3,000 7,221E-07 1,336E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 3,000 1,006E-06 1,73E-04 ! positive regulation of catabolic process GO:0009896 64 32 4,000 1,048E-06 1,681E-04 ! regulation of homeostatic process GO:0032844 134 62 5,000 1,551E-06 2,332E-04 ! positive regulation of glycolysis GO:0045821 14 5 2,000 1,847E-06 2,614E-04 ! positive regulation of viral genome replication GO:0045070 9 5 2,000 1,847E-06 2,469E-04 ! cellular response to insulin stimulus GO:0032869 82 37 4,000 2,217E-06 2,807E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 3,000 2,361E-06 2,84E-04 ! negative regulation of protein kinase activity GO:0006469 130 67 5,000 2,459E-06 2,817E-04 ! negative regulation of kinase activity GO:0033673 131 68 5,000 2,684E-06 2,935E-04 ! urogenital system development GO:0001655 137 69 5,000 2,926E-06 3,06E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 2,000 3,679E-06 3,688E-04 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 5,000 3,759E-06 3,618E-04 ! negative regulation of transferase activity GO:0051348 140 72 5,000 3,759E-06 3,479E-04 ! regulation of intracellular protein transport GO:0033157 80 42 4,000 4,227E-06 3,767E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 3,000 4,742E-06 4,074E-04 ! positive regulation of locomotion GO:0040017 39 21 3,000 5,831E-06 4,838E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 5,987E-06 4,801E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 6,41E-06 4,975E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 6,41E-06 4,82E-04 ! cranial nerve morphogenesis GO:0021602 11 7 2,000 6,41E-06 4,674E-04 ! positive regulation of monooxygenase activity GO:0032770 12 7 2,000 6,41E-06 4,536E-04 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 4,000 6,686E-06 4,596E-04 ! response to insulin stimulus GO:0032868 95 46 4,000 6,686E-06 4,468E-04 ! regulation of chemotaxis GO:0050920 40 22 3,000 7,095E-06 4,614E-04 ! cellular response to hormone stimulus GO:0032870 167 82 5,000 8,035E-06 5,087E-04 ! positive regulation of cell cycle GO:0045787 89 48 4,000 8,275E-06 5,105E-04 ! sex determination GO:0007530 47 23 3,000 8,55E-06 5,143E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 2,000 1,021E-05 5,993E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 1,021E-05 5,851E-04 ! regulation of cellular catabolic process GO:0031329 52 24 3,000 1,021E-05 5,715E-04 ! regulation of behavior GO:0050795 43 24 3,000 1,021E-05 5,585E-04 ! regulation of oxidoreductase activity GO:0051341 46 24 3,000 1,021E-05 5,461E-04 ! positive regulation of protein modification process GO:0031401 136 88 5,000 1,209E-05 6,322E-04 ! regulation of endothelial cell proliferation GO:0001936 57 26 3,000 1,424E-05 7,291E-04 ! regulation of developmental growth GO:0048638 15 9 2,000 1,525E-05 7,647E-04 ! positive regulation of glucose metabolic process GO:0010907 18 9 2,000 1,525E-05 7,49E-04 ! regulation of glycolysis GO:0006110 21 9 2,000 1,525E-05 7,341E-04 ! negative regulation of protein modification process GO:0031400 60 28 3,000 1,933E-05 9,12E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 4,000 1,941E-05 8,979E-04 ! positive regulation of cell migration GO:0030335 126 57 4,000 1,941E-05 8,81E-04 ! regulation of intracellular transport GO:0032386 101 57 4,000 1,941E-05 8,647E-04 ! regulation of bone resorption GO:0045124 25 10 2,000 2,17E-05 9,493E-04 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 2,17E-05 9,323E-04 ! positive regulation of viral reproduction GO:0048524 18 10 2,000 2,17E-05 9,16E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 2,000 2,17E-05 9,002E-04 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 2,17E-05 8,849E-04 ! protein amino acid autophosphorylation GO:0046777 141 60 4,000 2,496E-05 1,001E-03 ! response to peptide hormone stimulus GO:0043434 122 61 4,000 2,707E-05 1,068E-03 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 2,000 2,971E-05 1,153E-03 ! negative regulation of glucose import GO:0046325 17 11 2,000 2,971E-05 1,135E-03 GO:0010829|negative regulation of glucose transport, ! chondrocyte differentiation GO:0002062 24 11 2,000 2,971E-05 1,117E-03 ! metanephros development GO:0001656 74 32 3,000 3,335E-05 1,234E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 3,000 3,335E-05 1,216E-03 ! positive regulation of cell motion GO:0051272 146 64 4,000 3,421E-05 1,229E-03 ! cranial nerve development GO:0021545 20 12 2,000 3,945E-05 1,396E-03 ! autonomic nervous system development GO:0048483 24 12 2,000 3,945E-05 1,376E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 2,000 3,945E-05 1,356E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 4,000 4,274E-05 1,448E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 2,000 5,107E-05 1,706E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! learning or memory GO:0007611 147 73 4,000 6,465E-05 2,131E-03 ! regulation of erythrocyte differentiation GO:0045646 44 14 2,000 6,472E-05 2,104E-03 ! regulation of catabolic process GO:0009894 161 76 4,000 7,842E-05 2,516E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 8,056E-05 2,55E-03 ! positive regulation of oxidoreductase activity GO:0051353 22 15 2,000 8,056E-05 2,517E-03 ! regulation of glucose metabolic process GO:0010906 28 16 2,000 9,873E-05 3,045E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 2,000 9,873E-05 3,007E-03 ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 9,873E-05 2,969E-03 ! response to hypoxia GO:0001666 171 81 4,000 1,063E-04 3,157E-03 ! positive regulation of response to external stimulus GO:0032103 77 43 3,000 1,09E-04 3,197E-03 ! regulation of epithelial cell proliferation GO:0050678 111 43 3,000 1,09E-04 3,158E-03 ! response to oxygen levels GO:0070482 176 83 4,000 1,193E-04 3,418E-03 ! negative regulation of cell cycle process GO:0010948 32 17 2,000 1,194E-04 3,379E-03 ! regulation of viral genome replication GO:0045069 28 17 2,000 1,194E-04 3,34E-03 ! regulation of survival gene product expression GO:0045884 33 17 2,000 1,194E-04 3,301E-03 ! regulation of protein binding GO:0043393 33 17 2,000 1,194E-04 3,264E-03 ! neutrophil chemotaxis GO:0030593 27 17 2,000 1,194E-04 3,227E-03 ! negative regulation of transport GO:0051051 153 84 4,000 1,263E-04 3,376E-03 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 3,000 1,421E-04 3,758E-03 ! negative regulation of cell migration GO:0030336 115 46 3,000 1,421E-04 3,717E-03 ! response to retinoic acid GO:0032526 26 18 2,000 1,427E-04 3,691E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 1,427E-04 3,651E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 2,000 1,427E-04 3,613E-03 ! nerve development GO:0021675 28 18 2,000 1,427E-04 3,575E-03 ! regulation of protein transport GO:0051223 154 87 4,000 1,491E-04 3,697E-03 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 206 88 4,000 1,573E-04 3,862E-03 ! regulation of cell morphogenesis GO:0022604 215 89 4,000 1,659E-04 4,032E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 1,68E-04 4,042E-03 ! response to vitamin A GO:0033189 27 19 2,000 1,687E-04 4,018E-03 ! regulation of endothelial cell migration GO:0010594 44 19 2,000 1,687E-04 3,979E-03 ! peptide cross-linking GO:0018149 37 19 2,000 1,687E-04 3,94E-03 ! ossification GO:0001503 188 90 4,000 1,749E-04 4,045E-03 ! bone development GO:0060348 189 91 4,000 1,842E-04 4,22E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 2,000 1,976E-04 4,486E-03 ! response to vitamin GO:0033273 31 20 2,000 1,976E-04 4,444E-03 ! regulation of carbohydrate metabolic process GO:0006109 38 20 2,000 1,976E-04 4,402E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! apoptotic mitochondrial changes GO:0008637 41 20 2,000 1,976E-04 4,362E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 1,976E-04 4,322E-03 ! camera-type eye morphogenesis GO:0048593 42 20 2,000 1,976E-04 4,283E-03 ! regulation of glucose import GO:0046324 29 20 2,000 1,976E-04 4,245E-03 GO:0010827|regulation of glucose transport, ! positive regulation of MAP kinase activity GO:0043406 160 93 4,000 2,039E-04 4,342E-03 ! positive regulation of binding GO:0051099 78 51 3,000 2,129E-04 4,493E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 2,129E-04 4,454E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! interphase of mitotic cell cycle GO:0051329 209 95 4,000 2,253E-04 4,673E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 2,296E-04 4,721E-03 ! negative regulation of intracellular transport GO:0032387 41 21 2,000 2,296E-04 4,681E-03 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 2,296E-04 4,642E-03 ! positive regulation of growth GO:0045927 90 52 3,000 2,296E-04 4,603E-03 ! cartilage development GO:0051216 90 52 3,000 2,296E-04 4,565E-03 ! response to UV GO:0009411 104 53 3,000 2,472E-04 4,876E-03 ! regulation of protein localization GO:0032880 176 97 4,000 2,483E-04 4,856E-03 ! interphase GO:0051325 213 98 4,000 2,604E-04 5,053E-03 ! positive regulation of protein catabolic process GO:0045732 38 22 2,000 2,647E-04 5,095E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 2,647E-04 5,055E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 2,647E-04 5,015E-03 ! positive regulation of intracellular transport GO:0032388 37 22 2,000 2,647E-04 4,976E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 2,000 2,647E-04 4,937E-03 ! negative regulation of cell motion GO:0051271 134 55 3,000 2,854E-04 5,282E-03 ! positive regulation of cell adhesion GO:0045785 56 23 2,000 3,031E-04 5,567E-03 ! regulation of cell-matrix adhesion GO:0001952 78 23 2,000 3,031E-04 5,525E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 3,031E-04 5,484E-03 ! regulation of viral reproduction GO:0050792 38 23 2,000 3,031E-04 5,443E-03 ! hemoglobin biosynthetic process GO:0042541 7 5 1,000 3,244E-04 5,781E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,244E-04 5,738E-03 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 3,244E-04 5,696E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 3,244E-04 5,655E-03 ! anagen GO:0042640 6 5 1,000 3,244E-04 5,614E-03 ! smooth muscle tissue development GO:0048745 28 5 1,000 3,244E-04 5,574E-03 ! regulation of retroviral genome replication GO:0045091 7 5 1,000 3,244E-04 5,535E-03 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 3,244E-04 5,496E-03 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 1,000 3,244E-04 5,457E-03 ! microvillus organization GO:0032528 7 5 1,000 3,244E-04 5,42E-03 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 10 5 1,000 3,244E-04 5,382E-03 ! mRNA transcription GO:0009299 9 5 1,000 3,244E-04 5,345E-03 ! response to food GO:0032094 6 5 1,000 3,244E-04 5,309E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 3,244E-04 5,273E-03 ! paraxial mesoderm development GO:0048339 14 5 1,000 3,244E-04 5,238E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 3,244E-04 5,203E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 1,000 3,244E-04 5,168E-03 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 1,000 3,244E-04 5,134E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 3,244E-04 5,101E-03 ! forebrain morphogenesis GO:0048853 13 5 1,000 3,244E-04 5,068E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 3,244E-04 5,035E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 3,244E-04 5,003E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 3,244E-04 4,971E-03 GO:0022011|myelination in the peripheral nervous system, ! regulation of bone remodeling GO:0046850 137 57 3,000 3,276E-04 4,989E-03 ! protein import into nucleus, translocation GO:0000060 46 24 2,000 3,45E-04 5,22E-03 ! positive regulation of fibroblast proliferation GO:0048146 43 24 2,000 3,45E-04 5,188E-03 ! spinal cord development GO:0021510 47 24 2,000 3,45E-04 5,155E-03 ! regulation of tissue remodeling GO:0034103 140 58 3,000 3,503E-04 5,202E-03 ! skeletal system morphogenesis GO:0048705 105 59 3,000 3,741E-04 5,522E-03 ! myelination GO:0042552 45 25 2,000 3,904E-04 5,727E-03 ! vasculogenesis GO:0001570 46 25 2,000 3,904E-04 5,692E-03 ! negative regulation of cell development GO:0010721 73 25 2,000 3,904E-04 5,658E-03 GO:0050768|negative regulation of neurogenesis, ! camera-type eye development GO:0043010 116 60 3,000 3,99E-04 5,749E-03 ! kidney development GO:0001822 122 60 3,000 3,99E-04 5,715E-03 ! mesoderm development GO:0007498 119 61 3,000 4,251E-04 6,053E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 2,000 4,394E-04 6,219E-03 ! positive regulation of nuclear division GO:0051785 40 26 2,000 4,394E-04 6,183E-03 GO:0045840|positive regulation of mitosis, ! regulation of mitosis GO:0007088 105 63 3,000 4,81E-04 6,728E-03 GO:0051783|regulation of nuclear division, ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 4,847E-04 6,741E-03 ! forebrain regionalization GO:0021871 8 6 1,000 4,847E-04 6,702E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 1,000 4,847E-04 6,664E-03 ! embryonic hemopoiesis GO:0035162 14 6 1,000 4,847E-04 6,626E-03 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 1,000 4,847E-04 6,589E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 1,000 4,847E-04 6,552E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! activation of MAPKKK activity GO:0000185 12 6 1,000 4,847E-04 6,515E-03 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 1,000 4,847E-04 6,479E-03 ! male sex determination GO:0030238 15 6 1,000 4,847E-04 6,443E-03 ! establishment of spindle localization GO:0051293 12 6 1,000 4,847E-04 6,408E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,847E-04 6,373E-03 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 14 6 1,000 4,847E-04 6,338E-03 ! astrocyte development GO:0014002 15 6 1,000 4,847E-04 6,304E-03 ! hair follicle maturation GO:0048820 7 6 1,000 4,847E-04 6,27E-03 ! Schwann cell development GO:0014044 15 6 1,000 4,847E-04 6,236E-03 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 4,847E-04 6,203E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 4,847E-04 6,17E-03 ! negative regulation of axon extension GO:0030517 21 6 1,000 4,847E-04 6,138E-03 ! ectodermal gut morphogenesis GO:0048567 12 6 1,000 4,847E-04 6,106E-03 GO:0007439|ectodermal gut development, ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 4,923E-04 6,169E-03 ! regulation of chromosome organization GO:0033044 42 27 2,000 4,923E-04 6,137E-03 ! peptidyl-tyrosine modification GO:0018212 50 28 2,000 5,49E-04 6,809E-03 ! lung development GO:0030324 144 67 3,000 6,08E-04 7,501E-03 ! cellular iron ion homeostasis GO:0006879 51 29 2,000 6,098E-04 7,486E-03 ! positive regulation of multicellular organism growth GO:0040018 51 30 2,000 6,747E-04 8,24E-03 ! ensheathment of neurons GO:0007272 57 30 2,000 6,747E-04 8,199E-03 GO:0008366|axon ensheathment, ! eye morphogenesis GO:0048592 60 30 2,000 6,747E-04 8,158E-03 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 1,000 6,76E-04 8,132E-03 ! prostate gland development GO:0030850 13 7 1,000 6,76E-04 8,092E-03 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 6,76E-04 8,052E-03 ! neuron adhesion GO:0007158 12 7 1,000 6,76E-04 8,012E-03 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 6,76E-04 7,973E-03 ! mRNA stabilization GO:0048255 18 7 1,000 6,76E-04 7,934E-03 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 10 7 1,000 6,76E-04 7,896E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 6,76E-04 7,857E-03 ! spinal cord patterning GO:0021511 13 7 1,000 6,76E-04 7,82E-03 ! adrenal gland development GO:0030325 17 7 1,000 6,76E-04 7,782E-03 ! spindle checkpoint GO:0031577 15 7 1,000 6,76E-04 7,745E-03 ! wound healing, spreading of epidermal cells GO:0035313 14 7 1,000 6,76E-04 7,708E-03 ! oxygen homeostasis GO:0032364 12 7 1,000 6,76E-04 7,672E-03 ! regulation of respiratory burst GO:0060263 11 7 1,000 6,76E-04 7,636E-03 ! axonal fasciculation GO:0007413 18 7 1,000 6,76E-04 7,6E-03 ! negative regulation of nuclear division GO:0051784 14 7 1,000 6,76E-04 7,565E-03 GO:0045839|negative regulation of mitosis, ! respiratory tube development GO:0030323 150 70 3,000 7,176E-04 7,993E-03 ! iron ion homeostasis GO:0055072 54 31 2,000 7,439E-04 8,248E-03 ! reproductive structure development GO:0048608 113 71 3,000 7,571E-04 8,356E-03 ! respiratory system development GO:0060541 153 72 3,000 7,981E-04 8,768E-03 ! regulation of axonogenesis GO:0050770 75 32 2,000 8,174E-04 8,939E-03 ! regulation of protein import into nucleus GO:0042306 63 32 2,000 8,174E-04 8,899E-03 ! peripheral nervous system development GO:0007422 64 32 2,000 8,174E-04 8,859E-03 ! eye development GO:0001654 143 74 3,000 8,847E-04 9,545E-03 ! leukocyte chemotaxis GO:0030595 50 33 2,000 8,953E-04 9,617E-03 GO:0060326|cell chemotaxis, ! negative regulation of protein transport GO:0051224 69 33 2,000 8,953E-04 9,574E-03 ! hemoglobin metabolic process GO:0020027 13 8 1,000 8,979E-04 9,56E-03 ! regulation of defense response to virus by virus GO:0050690 18 8 1,000 8,979E-04 9,517E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 8,979E-04 9,476E-03 ! Schwann cell differentiation GO:0014037 19 8 1,000 8,979E-04 9,434E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 8,979E-04 9,393E-03 ! succinate metabolic process GO:0006105 14 8 1,000 8,979E-04 9,353E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 8,979E-04 9,312E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 8,979E-04 9,272E-03 ! astrocyte differentiation GO:0048708 18 8 1,000 8,979E-04 9,233E-03 ! ER overload response GO:0006983 12 8 1,000 8,979E-04 9,193E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 8,979E-04 9,155E-03 ! DNA topological change GO:0006265 12 8 1,000 8,979E-04 9,116E-03 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 1,000 8,979E-04 9,078E-03 ! placenta development GO:0001890 53 34 2,000 9,778E-04 9,844E-03 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 2,000 1,065E-03 0,01067691 ! embryonic skeletal system morphogenesis GO:0048704 59 35 2,000 1,065E-03 0,01063261 ! telencephalon development GO:0021537 68 35 2,000 1,065E-03 0,01058867 ! negative regulation of organelle organization GO:0010639 161 78 3,000 1,077E-03 0,01066734 ! artery development GO:0060840 24 9 1,000 1,15E-03 0,01134121 GO:0048844|artery morphogenesis, ! microtubule bundle formation GO:0001578 21 9 1,000 1,15E-03 0,01129492 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,15E-03 0,01124901 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,15E-03 0,01120347 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 16 9 1,000 1,15E-03 0,01115829 ! protein heterooligomerization GO:0051291 16 9 1,000 1,15E-03 0,01111348 ! gas homeostasis GO:0033483 16 9 1,000 1,15E-03 0,01106902 ! spinal cord motor neuron differentiation GO:0021522 15 9 1,000 1,15E-03 0,01102492 ! positive regulation of erythrocyte differentiation GO:0045648 29 9 1,000 1,15E-03 0,01098117 ! regulation of synaptogenesis GO:0051963 15 9 1,000 1,15E-03 0,01093777 ! regulation of telomere maintenance GO:0032204 14 9 1,000 1,15E-03 0,01089471 ! embryonic organ development GO:0048568 57 36 2,000 1,157E-03 0,01091636 ! regulation of neuron differentiation GO:0045664 167 81 3,000 1,24E-03 0,01165388 ! tissue remodeling GO:0048771 76 37 2,000 1,254E-03 0,01173765 ! glycogen metabolic process GO:0005977 61 37 2,000 1,254E-03 0,01169215 ! regulation of neuron projection development GO:0010975 91 38 2,000 1,356E-03 0,01259226 ! mitotic cell cycle checkpoint GO:0007093 76 38 2,000 1,356E-03 0,01254383 ! carbohydrate homeostasis GO:0033500 53 38 2,000 1,356E-03 0,01249577 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 67 38 2,000 1,356E-03 0,01244808 ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 1,356E-03 0,01240075 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 2,000 1,356E-03 0,01235377 ! glucan metabolic process GO:0044042 62 38 2,000 1,356E-03 0,01230716 GO:0006073|cellular glucan metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 1,000 1,432E-03 0,01295495 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 1,432E-03 0,01290643 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 1,432E-03 0,01285827 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 1,432E-03 0,01281047 ! smoothened signaling pathway GO:0007224 16 10 1,000 1,432E-03 0,01276303 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 1,000 1,432E-03 0,01271593 ! lung alveolus development GO:0048286 26 10 1,000 1,432E-03 0,01266918 ! glucan biosynthetic process GO:0009250 14 10 1,000 1,432E-03 0,01262277 GO:0005978|glycogen biosynthetic process, ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 1,000 1,432E-03 0,0125767 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,432E-03 0,01253097 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 1,000 1,432E-03 0,01248557 ! negative regulation of axonogenesis GO:0050771 32 10 1,000 1,432E-03 0,0124405 ! DNA ligation GO:0006266 19 10 1,000 1,432E-03 0,01239575 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 1,432E-03 0,01235132 ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 1,432E-03 0,0123072 ! localization within membrane GO:0051668 20 10 1,000 1,432E-03 0,01226341 ! mammary gland development GO:0030879 86 39 2,000 1,462E-03 0,01247644 ! learning GO:0007612 77 39 2,000 1,462E-03 0,01243236 ! regulation of action potential in neuron GO:0019228 73 39 2,000 1,462E-03 0,01238858 ! multicellular organismal metabolic process GO:0044236 57 40 2,000 1,574E-03 0,0132901 ! gliogenesis GO:0042063 88 41 2,000 1,691E-03 0,01422927 ! regulation of T cell proliferation GO:0042129 71 41 2,000 1,691E-03 0,01417969 ! T cell differentiation GO:0030217 81 41 2,000 1,691E-03 0,01413045 ! dorsal/ventral pattern formation GO:0009953 68 41 2,000 1,691E-03 0,01408156 ! neuron fate specification GO:0048665 17 11 1,000 1,744E-03 0,01446866 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,744E-03 0,01441894 ! blood vessel remodeling GO:0001974 29 11 1,000 1,744E-03 0,01436956 ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 1,744E-03 0,01432052 ! ventral spinal cord development GO:0021517 21 11 1,000 1,744E-03 0,01427181 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 1,000 1,744E-03 0,01422343 ! regulation of leukocyte migration GO:0002685 26 11 1,000 1,744E-03 0,01417538 ! embryonic gut development GO:0048566 15 11 1,000 1,744E-03 0,01412765 ! regulation of embryonic development GO:0045995 27 11 1,000 1,744E-03 0,01408024 ! regulation of synapse organization GO:0050807 17 11 1,000 1,744E-03 0,01403315 ! regulation of cell adhesion GO:0030155 212 89 3,000 1,756E-03 0,01408515 ! regulation of myeloid cell differentiation GO:0045637 98 42 2,000 1,814E-03 0,01449915 ! regulation of cell cycle process GO:0010564 149 90 3,000 1,83E-03 0,01457786 ! sex differentiation GO:0007548 145 90 3,000 1,83E-03 0,01452974 ! epithelial cell differentiation GO:0030855 79 43 2,000 1,942E-03 0,0153681 ! energy reserve metabolic process GO:0006112 74 43 2,000 1,942E-03 0,01531771 ! regulation of defense response GO:0031347 149 92 3,000 1,983E-03 0,01559392 ! male sex differentiation GO:0046661 76 44 2,000 2,075E-03 0,01626301 ! developmental growth GO:0048589 82 44 2,000 2,075E-03 0,01621021 ! negative regulation of cell projection organization GO:0031345 37 12 1,000 2,085E-03 0,01623337 ! virus-host interaction GO:0019048 29 12 1,000 2,085E-03 0,01618101 ! regulation of B cell proliferation GO:0030888 20 12 1,000 2,085E-03 0,01612898 ! cytokine biosynthetic process GO:0042089 21 12 1,000 2,085E-03 0,01607728 ! histone acetylation GO:0016573 26 12 1,000 2,085E-03 0,01602592 ! regulation of hormone metabolic process GO:0032350 26 12 1,000 2,085E-03 0,01597488 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,085E-03 0,01592417 ! T cell homeostasis GO:0043029 25 12 1,000 2,085E-03 0,01587377 ! digestive tract morphogenesis GO:0048546 26 12 1,000 2,085E-03 0,0158237 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 23 12 1,000 2,085E-03 0,01577394 GO:0042130|negative regulation of T cell proliferation, ! regulation of synapse structure and activity GO:0050803 18 12 1,000 2,085E-03 0,01572449 ! leukocyte migration GO:0050900 68 45 2,000 2,214E-03 0,01664676 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 2,359E-03 0,01767835 ! pigmentation GO:0043473 100 46 2,000 2,359E-03 0,01762345 ! positive regulation of protein transport GO:0051222 72 46 2,000 2,359E-03 0,01756889 ! regulation of chemokine production GO:0032642 18 13 1,000 2,455E-03 0,01822776 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 2,455E-03 0,01817167 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 1,000 2,455E-03 0,01811593 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,455E-03 0,01806053 ! cytokine metabolic process GO:0042107 22 13 1,000 2,455E-03 0,01800547 ! positive regulation of Ras GTPase activity GO:0032320 35 13 1,000 2,455E-03 0,01795074 ! regulation of mRNA stability GO:0043488 31 13 1,000 2,455E-03 0,01789634 ! embryonic placenta development GO:0001892 23 13 1,000 2,455E-03 0,01784228 ! positive regulation of defense response GO:0031349 76 47 2,000 2,509E-03 0,0181816 ! regulation of inflammatory response GO:0050727 75 48 2,000 2,665E-03 0,01925455 ! cell cycle arrest GO:0007050 213 100 3,000 2,686E-03 0,01935133 ! regulation of action potential GO:0001508 95 49 2,000 2,827E-03 0,02030254 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 2,827E-03 0,02024212 ! positive regulation of GTPase activity GO:0043547 36 14 1,000 2,853E-03 0,02036837 ! regulation of mRNA processing GO:0050684 24 14 1,000 2,853E-03 0,02030811 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 2,853E-03 0,0202482 GO:0060675|ureteric bud morphogenesis, ! bone mineralization GO:0030282 17 14 1,000 2,853E-03 0,02018865 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 2,853E-03 0,02012944 ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 2,853E-03 0,02007058 ! regulation of RNA stability GO:0043487 32 14 1,000 2,853E-03 0,02001207 ! regulation of axon extension GO:0030516 37 14 1,000 2,853E-03 0,01995389 ! release of cytochrome c from mitochondria GO:0001836 30 14 1,000 2,853E-03 0,01989606 ! regulation of cell projection organization GO:0031344 121 50 2,000 2,995E-03 0,02082433 ! embryonic skeletal system development GO:0048706 85 51 2,000 3,169E-03 0,02196983 ! regulation of cell shape GO:0008360 125 51 2,000 3,169E-03 0,0219067 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 3,279E-03 0,02260843 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 3,279E-03 0,02254383 ! heterophilic cell adhesion GO:0007157 39 15 1,000 3,279E-03 0,02247961 ! positive regulation of axonogenesis GO:0050772 28 15 1,000 3,279E-03 0,02241574 ! muscle maintenance GO:0046716 26 15 1,000 3,279E-03 0,02235224 ! lymphocyte homeostasis GO:0002260 30 15 1,000 3,279E-03 0,0222891 ! epithelial to mesenchymal transition GO:0001837 28 15 1,000 3,279E-03 0,02222632 ! regulation of muscle contraction GO:0006937 81 52 2,000 3,348E-03 0,02263051 ! regulation of neuron apoptosis GO:0043523 100 53 2,000 3,535E-03 0,02382117 ! cell recognition GO:0008037 85 54 2,000 3,727E-03 0,02504688 ! G1 phase of mitotic cell cycle GO:0000080 35 16 1,000 3,734E-03 0,02502395 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 1,000 3,734E-03 0,02495444 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 1,000 3,734E-03 0,02488532 ! activation of MAPKK activity GO:0000186 35 16 1,000 3,734E-03 0,02481657 ! regulation of defense response to virus GO:0050688 27 16 1,000 3,734E-03 0,02474821 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 3,734E-03 0,02468022 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of protein import into nucleus GO:0042307 30 16 1,000 3,734E-03 0,0246126 ! neuron recognition GO:0008038 35 16 1,000 3,734E-03 0,02454535 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 3,734E-03 0,02447847 ! biomineral formation GO:0031214 20 16 1,000 3,734E-03 0,02441195 ! negative regulation of leukocyte proliferation GO:0070664 31 16 1,000 3,734E-03 0,0243458 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! cellular polysaccharide metabolic process GO:0044264 86 55 2,000 3,925E-03 0,02552564 ! regulation of protein catabolic process GO:0042176 116 55 2,000 3,925E-03 0,02545683 ! heart morphogenesis GO:0003007 97 55 2,000 3,925E-03 0,0253884 ! regulation of multicellular organism growth GO:0040014 85 55 2,000 3,925E-03 0,02532034 ! positive regulation of organelle organization GO:0010638 100 56 2,000 4,13E-03 0,02657061 ! glial cell development GO:0021782 27 17 1,000 4,216E-03 0,02704831 ! heart looping GO:0001947 30 17 1,000 4,216E-03 0,02697637 ! cell differentiation in spinal cord GO:0021515 30 17 1,000 4,216E-03 0,02690481 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 1,000 4,216E-03 0,02683364 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 1,000 4,216E-03 0,02676284 ! neural crest cell migration GO:0001755 37 17 1,000 4,216E-03 0,02669241 ! branched chain family amino acid metabolic process GO:0009081 33 17 1,000 4,216E-03 0,02662235 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 4,216E-03 0,02655266 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 4,216E-03 0,02648333 ! lipid modification GO:0030258 97 57 2,000 4,342E-03 0,02720234 ! positive regulation of anti-apoptosis GO:0045768 39 18 1,000 4,725E-03 0,02952754 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 4,725E-03 0,02945104 ! memory GO:0007613 31 18 1,000 4,725E-03 0,02937494 ! positive regulation of proteolysis GO:0045862 31 18 1,000 4,725E-03 0,02929923 ! cell-substrate junction assembly GO:0007044 54 18 1,000 4,725E-03 0,02922391 ! positive regulation of synaptic transmission GO:0050806 28 18 1,000 4,725E-03 0,02914898 ! DNA catabolic process GO:0006308 86 59 2,000 4,783E-03 0,0294346 ! regulation of heart contraction GO:0008016 110 60 2,000 5,014E-03 0,03077584 ! negative regulation of response to stimulus GO:0048585 100 60 2,000 5,014E-03 0,03069753 ! protein secretion GO:0009306 39 19 1,000 5,261E-03 0,03212634 ! positive regulation of translation GO:0045727 30 19 1,000 5,261E-03 0,03204501 ! positive regulation of angiogenesis GO:0045766 44 19 1,000 5,261E-03 0,03196408 ! lipid phosphorylation GO:0046834 35 19 1,000 5,261E-03 0,03188357 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 5,261E-03 0,03180346 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 1,000 5,261E-03 0,03172375 ! cerebral cortex development GO:0021987 36 19 1,000 5,261E-03 0,03164444 ! neuromuscular junction development GO:0007528 34 19 1,000 5,261E-03 0,03156553 ! plasma membrane fusion GO:0045026 28 19 1,000 5,261E-03 0,03148701 ! visual learning GO:0008542 36 19 1,000 5,261E-03 0,03140888 ! G1 phase GO:0051318 40 19 1,000 5,261E-03 0,03133113 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 1,000 5,261E-03 0,03125377 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 1,000 5,261E-03 0,03117679 ! proximal/distal pattern formation GO:0009954 32 19 1,000 5,261E-03 0,03110019 ! embryonic organ morphogenesis GO:0048562 26 19 1,000 5,261E-03 0,03102396 ! gonad development GO:0008406 98 62 2,000 5,496E-03 0,03232848 ! protein amino acid acetylation GO:0006473 39 20 1,000 5,824E-03 0,03417407 ! response to alkaloid GO:0043279 38 20 1,000 5,824E-03 0,03409092 ! regulation of interleukin-2 production GO:0032663 35 20 1,000 5,824E-03 0,03400817 ! negative regulation of angiogenesis GO:0016525 45 20 1,000 5,824E-03 0,03392583 ! positive regulation of neurological system process GO:0031646 32 20 1,000 5,824E-03 0,03384388 ! negative regulation of T cell activation GO:0050868 40 20 1,000 5,824E-03 0,03376233 ! negative regulation of translation GO:0017148 29 20 1,000 5,824E-03 0,03368117 ! germ cell development GO:0007281 118 65 2,000 6,268E-03 0,03616546 ! cell structure disassembly during apoptosis GO:0006921 30 21 1,000 6,412E-03 0,03690934 ! cholesterol biosynthetic process GO:0006695 37 21 1,000 6,412E-03 0,03682125 ! collagen fibril organization GO:0030199 59 21 1,000 6,412E-03 0,03673358 ! gut development GO:0048565 39 21 1,000 6,412E-03 0,03664633 ! activation of MAPK activity GO:0000187 115 67 2,000 6,817E-03 0,03886798 ! chromosome segregation GO:0007059 113 67 2,000 6,817E-03 0,03877609 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 1,000 7,027E-03 0,03987553 ! glutamate signaling pathway GO:0007215 41 22 1,000 7,027E-03 0,03978171 ! ureteric bud development GO:0001657 43 22 1,000 7,027E-03 0,03968832 ! positive regulation of B cell activation GO:0050871 38 22 1,000 7,027E-03 0,03959538 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 1,000 7,027E-03 0,03950286 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 2,000 7,102E-03 0,03983194 ! cell cycle checkpoint GO:0000075 137 69 2,000 7,394E-03 0,04137279 ! negative regulation of cell size GO:0045792 134 69 2,000 7,394E-03 0,0412768 ! positive regulation of DNA replication GO:0045740 43 23 1,000 7,667E-03 0,04270365 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 1,000 7,667E-03 0,04260503 ! regulation of anti-apoptosis GO:0045767 53 23 1,000 7,667E-03 0,04250686 ! leukocyte adhesion GO:0007159 50 23 1,000 7,667E-03 0,04240914 ! visual behavior GO:0007632 42 23 1,000 7,667E-03 0,04231187 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 2,000 8,312E-03 0,04576453 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 1,000 8,333E-03 0,04577536 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 1,000 8,333E-03 0,04567109 ! pallium development GO:0021543 49 24 1,000 8,333E-03 0,04556729 ! leukocyte homeostasis GO:0001776 44 24 1,000 8,333E-03 0,04546396 ! regulation of multi-organism process GO:0043900 36 24 1,000 8,333E-03 0,0453611 ! protein tetramerization GO:0051262 52 24 1,000 8,333E-03 0,04525871 ! axon guidance GO:0007411 139 73 2,000 8,632E-03 0,04677822 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 1,000 9,024E-03 0,04878962 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 1,000 9,024E-03 0,04868022 ! dicarboxylic acid metabolic process GO:0043648 42 25 1,000 9,024E-03 0,04857132 ! chromosome condensation GO:0030261 45 25 1,000 9,024E-03 0,0484629 ! osteoblast differentiation GO:0001649 60 25 1,000 9,024E-03 0,04835497 ! response to endoplasmic reticulum stress GO:0034976 43 25 1,000 9,024E-03 0,04824751 ! neural crest cell development GO:0014032 54 25 1,000 9,024E-03 0,04814053 GO:0014033|neural crest cell differentiation, ! interaction with host GO:0051701 62 25 1,000 9,024E-03 0,04803403 ! somitogenesis GO:0001756 43 25 1,000 9,024E-03 0,04792799 ! liver development GO:0001889 53 25 1,000 9,024E-03 0,04782242 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 9,294E-03 0,04914753 ! lymphocyte differentiation GO:0030098 167 75 2,000 9,294E-03 0,04903976 ! development of primary sexual characteristics GO:0045137 124 76 2,000 9,636E-03 0,05073184 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 1,000 9,739E-03 0,05116278 ! molting cycle process GO:0022404 50 26 1,000 9,739E-03 0,05105132 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 54 26 1,000 9,739E-03 0,05094034 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 1,000 9,739E-03 0,05082984 ! cellular response to oxidative stress GO:0034599 39 26 1,000 9,739E-03 0,05071982 ! regulation of response to biotic stimulus GO:0002831 44 26 1,000 9,739E-03 0,05061027 ! regulation of osteoblast differentiation GO:0045667 65 26 1,000 9,739E-03 0,0505012 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 9,985E-03 0,05166498 ! neuron fate commitment GO:0048663 48 27 1,000 0,01047897 0,05410388 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 0,01047897 0,05398802 ! positive regulation of cell projection organization GO:0031346 58 27 1,000 0,01047897 0,05387266 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 0,01047897 0,05375779 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01047897 0,05364342 ! male gonad development GO:0008584 44 27 1,000 0,01047897 0,05352952 ! glutathione metabolic process GO:0006749 39 27 1,000 0,01047897 0,05341611 ! negative regulation of lymphocyte activation GO:0051250 53 27 1,000 0,01047897 0,05330318 ! activation of protein kinase activity GO:0032147 147 79 2,000 0,01070506 0,05433832 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 2,000 0,01070506 0,05422392 ! protein import into nucleus GO:0006606 158 80 2,000 0,01107601 0,05598502 ! dendrite development GO:0016358 59 28 1,000 0,01124281 0,05670903 ! ER-nuclear signaling pathway GO:0006984 48 28 1,000 0,01124281 0,05659039 ! lipid oxidation GO:0034440 43 28 1,000 0,01124281 0,05647225 GO:0019395|fatty acid oxidation, ! T cell activation GO:0042110 168 81 2,000 0,01145431 0,05741475 ! nuclear import GO:0051170 161 81 2,000 0,01145431 0,05729538 ! response to nutrient GO:0007584 125 82 2,000 0,01184 0,05910177 ! sterol biosynthetic process GO:0016126 52 29 1,000 0,01203044 0,05992804 ! cellular response to extracellular stimulus GO:0031668 48 29 1,000 0,01203044 0,05980423 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 1,000 0,01203044 0,05968092 ! tissue homeostasis GO:0001894 48 29 1,000 0,01203044 0,05955812 GO:0048871|multicellular organismal homeostasis, ! negative regulation of growth GO:0045926 155 84 2,000 0,01263362 0,0624158 ! regulation of ligase activity GO:0051340 142 84 2,000 0,01263362 0,0622879 ! cell junction assembly GO:0034329 78 30 1,000 0,01284157 0,06318366 ! acute-phase response GO:0006953 49 30 1,000 0,01284157 0,06305471 ! negative regulation of leukocyte activation GO:0002695 56 30 1,000 0,01284157 0,06292629 ! neurotransmitter secretion GO:0007269 48 30 1,000 0,01284157 0,06279839 ! regulation of B cell activation GO:0050864 50 30 1,000 0,01284157 0,06267101 ! response to heat GO:0009408 50 30 1,000 0,01284157 0,06254415 ! negative regulation of protein kinase cascade GO:0010741 68 30 1,000 0,01284157 0,06241779 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,01304159 0,06326223 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 148 86 2,000 0,01345702 0,06514607 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 1,000 0,01367589 0,06607268 ! collagen metabolic process GO:0032963 45 31 1,000 0,01367589 0,06594027 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 1,000 0,01367589 0,06580838 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,01367589 0,06567703 ! mesoderm formation GO:0001707 69 31 1,000 0,01367589 0,0655462 ! fatty acid catabolic process GO:0009062 48 31 1,000 0,01367589 0,06541589 ! protein localization in nucleus GO:0034504 176 87 2,000 0,01387994 0,06626019 ! spindle organization GO:0007051 46 32 1,000 0,01453313 0,06924099 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,01453313 0,06910415 ! regulation of ARF GTPase activity GO:0032312 65 32 1,000 0,01453313 0,06896785 ! hindbrain development GO:0030902 61 32 1,000 0,01453313 0,06883209 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,01541298 0,07285587 ! positive regulation of neurogenesis GO:0050769 67 33 1,000 0,01541298 0,07271301 ! formation of primary germ layer GO:0001704 72 33 1,000 0,01541298 0,07257072 ! cell fate specification GO:0001708 52 33 1,000 0,01541298 0,07242898 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 1,000 0,01631518 0,07651914 ! glial cell differentiation GO:0010001 63 34 1,000 0,01631518 0,07637027 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01631518 0,07622198 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 1,000 0,01631518 0,07607427 ! mesoderm morphogenesis GO:0048332 76 34 1,000 0,01631518 0,07592712 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 0,01631518 0,07578054 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 2,000 0,01657547 0,0768412 GO:0010498|proteasomal protein catabolic process, ! regulation of membrane potential GO:0042391 164 93 2,000 0,01657547 0,07669343 ! transcription initiation GO:0006352 153 94 2,000 0,01705119 0,0787431 ! regulation of T cell activation GO:0050863 158 94 2,000 0,01705119 0,07859225 ! regulation of muscle development GO:0048634 70 35 1,000 0,01723943 0,07930797 ! odontogenesis GO:0042476 66 35 1,000 0,01723943 0,07915662 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,01723943 0,07900585 ! cytokine production GO:0001816 59 35 1,000 0,01723943 0,07885565 ! regulation of microtubule-based process GO:0032886 78 35 1,000 0,01723943 0,07870602 ! forebrain development GO:0030900 188 95 2,000 0,01753449 0,07990149 ! leukocyte differentiation GO:0002521 202 96 2,000 0,0180254 0,08198318 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,01818546 0,08255512 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 1,000 0,01818546 0,08239964 ! cell junction organization GO:0034330 86 36 1,000 0,01818546 0,08224476 ! positive regulation of cell development GO:0010720 80 36 1,000 0,01818546 0,08209045 ! regulation of proteolysis GO:0030162 72 36 1,000 0,01818546 0,08193673 ! negative regulation of cell activation GO:0050866 65 36 1,000 0,01818546 0,08178357 ! regulation of DNA metabolic process GO:0051052 178 97 2,000 0,01852391 0,08315022 ! protein ubiquitination GO:0016567 217 97 2,000 0,01852391 0,08299538 ! meiosis I GO:0007127 65 37 1,000 0,01915298 0,08565442 ! sister chromatid segregation GO:0000819 58 37 1,000 0,01915298 0,0854955 ! skeletal muscle tissue development GO:0007519 186 99 2,000 0,01954377 0,08707835 GO:0060538|skeletal muscle organ development, ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,02014173 0,08957672 ! ear morphogenesis GO:0042471 60 39 1,000 0,02115143 0,09389361 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,02115143 0,09372069 ! segmentation GO:0035282 67 39 1,000 0,02115143 0,09354841 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 1,000 0,0221818 0,09792555 ! mesenchymal cell development GO:0014031 87 40 1,000 0,0221818 0,09774619 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! cytokinesis GO:0000910 72 40 1,000 0,0221818 0,0975675 ! cellular amide metabolic process GO:0043603 67 41 1,000 0,02323259 0,10200296 ! keratinocyte differentiation GO:0030216 62 41 1,000 0,02323259 0,10181716 ! regulation of T cell differentiation GO:0045580 70 41 1,000 0,02323259 0,10163204 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,02430353 0,10612394 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,02430353 0,10593168 ! neuron migration GO:0001764 79 42 1,000 0,02430353 0,10574012 ! glucose transport GO:0015758 65 43 1,000 0,02539435 0,11028663 ! neural tube development GO:0021915 77 43 1,000 0,02539435 0,11008792 ! hexose transport GO:0008645 67 44 1,000 0,02650478 0,11469517 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 1,000 0,02650478 0,11448925 ! JAK-STAT cascade GO:0007259 71 44 1,000 0,02650478 0,11428407 ! regulation of JAK-STAT cascade GO:0046425 70 45 1,000 0,02763459 0,11894243 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,02763459 0,11873003 ! branching morphogenesis of a tube GO:0048754 97 45 1,000 0,02763459 0,11851839 ! polysaccharide biosynthetic process GO:0000271 70 45 1,000 0,02763459 0,1183075 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 1,000 0,02763459 0,11809737 ! cell growth GO:0016049 84 45 1,000 0,02763459 0,11788797 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02839511 0,12091793 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02839511 0,1207043 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02839511 0,12049141 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02839511 0,12027928 ! neuron fate determination GO:0048664 7 5 0,000 0,02839511 0,12006789 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02839511 0,11985725 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02839511 0,11964734 ! polyol transport GO:0015791 12 5 0,000 0,02839511 0,11943817 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02839511 0,11922972 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02839511 0,11902201 ! response to superoxide GO:0000303 10 5 0,000 0,02839511 0,11881501 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02839511 0,11860873 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02839511 0,11840317 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02839511 0,11819832 ! female meiosis GO:0007143 7 5 0,000 0,02839511 0,11799418 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02839511 0,11779074 ! cobalt ion transport GO:0006824 11 5 0,000 0,02839511 0,11758801 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02839511 0,11738596 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02839511 0,11718462 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02839511 0,11698396 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02839511 0,11678398 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02839511 0,11658469 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,02839511 0,11638608 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02839511 0,11618815 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02839511 0,11599088 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02839511 0,11579429 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02839511 0,11559836 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02839511 0,11540309 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02839511 0,11520848 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 0,000 0,02839511 0,11501453 ! negative chemotaxis GO:0050919 14 5 0,000 0,02839511 0,11482123 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02839511 0,11462858 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02839511 0,11443657 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02839511 0,1142452 ! behavioral response to pain GO:0048266 9 5 0,000 0,02839511 0,11405448 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02839511 0,11386439 ! Notch receptor processing GO:0007220 8 5 0,000 0,02839511 0,11367493 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02839511 0,1134861 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02839511 0,1132979 ! micturition GO:0060073 9 5 0,000 0,02839511 0,11311032 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02839511 0,11292336 ! copulation GO:0007620 9 5 0,000 0,02839511 0,11273701 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02839511 0,11255129 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02839511 0,11236617 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02839511 0,11218166 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02839511 0,11199776 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02839511 0,11181445 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02839511 0,11163175 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02839511 0,11144964 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02839511 0,11126813 ! grooming behavior GO:0007625 6 5 0,000 0,02839511 0,11108721 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02839511 0,11090687 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02839511 0,11072712 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02839511 0,11054795 ! response to protozoan GO:0001562 10 5 0,000 0,02839511 0,11036936 ! lymph vessel development GO:0001945 10 5 0,000 0,02839511 0,11019134 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02839511 0,1100139 ! endochondral ossification GO:0001958 16 5 0,000 0,02839511 0,10983703 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02839511 0,10966072 ! parathyroid gland development GO:0060017 13 5 0,000 0,02839511 0,10948499 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02839511 0,10930981 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,02839511 0,10913519 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02839511 0,10896113 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02839511 0,10878763 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02839511 0,10861468 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02839511 0,10844227 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,02839511 0,10827041 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02839511 0,1080991 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02839511 0,10792833 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02839511 0,10775809 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,02839511 0,1075884 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02839511 0,10741923 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02839511 0,1072506 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02839511 0,10708249 ! histidine catabolic process GO:0006548 6 5 0,000 0,02839511 0,10691492 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02839511 0,10674786 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,02839511 0,10658133 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02839511 0,10641531 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02839511 0,10624982 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02839511 0,10608483 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02839511 0,10592036 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02839511 0,10575639 ! polyol catabolic process GO:0046174 7 5 0,000 0,02839511 0,10559294 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02839511 0,10542999 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02839511 0,10526754 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02839511 0,10510559 ! muscle cell migration GO:0014812 8 5 0,000 0,02839511 0,10494413 ! mitochondrial fission GO:0000266 8 5 0,000 0,02839511 0,10478318 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02839511 0,10462271 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02839511 0,10446274 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02839511 0,10430325 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,02839511 0,10414425 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02839511 0,10398574 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02839511 0,10382771 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02839511 0,10367015 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02839511 0,10351308 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02839511 0,10335648 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02839511 0,10320035 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02839511 0,10304469 ! forebrain neuron development GO:0021884 13 5 0,000 0,02839511 0,1028895 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02839511 0,10273478 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02839511 0,10258053 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02839511 0,10242673 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02839511 0,1022734 ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,02839511 0,10212052 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02839511 0,10196811 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02839511 0,10181614 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02839511 0,10166463 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02839511 0,10151357 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02839511 0,10136295 ! basic amino acid transport GO:0015802 11 5 0,000 0,02839511 0,10121279 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02839511 0,10106306 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,02839511 0,10091378 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02839511 0,10076494 ! depyrimidination GO:0045008 10 5 0,000 0,02839511 0,10061654 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02839511 0,10046858 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02839511 0,10032104 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02839511 0,10017395 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02839511 0,10002728 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02839511 0,09988104 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02839511 0,09973523 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02839511 0,09958984 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02839511 0,09944488 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02839511 0,09930034 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02839511 0,09915621 ! response to arsenic GO:0046685 10 5 0,000 0,02839511 0,09901251 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,02839511 0,09886922 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02839511 0,09872635 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02839511 0,09858388 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,02839511 0,09844183 ! response to cadmium ion GO:0046686 7 5 0,000 0,02839511 0,09830019 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02839511 0,09815895 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02839511 0,09801812 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02839511 0,09787769 ! decidualization GO:0046697 11 5 0,000 0,02839511 0,09773767 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02839511 0,09759804 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02839511 0,09745882 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02839511 0,09731999 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02839511 0,09718155 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02839511 0,09704351 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02839511 0,09690586 ! neural tube patterning GO:0021532 7 5 0,000 0,02839511 0,0967686 ! embryonic cleavage GO:0040016 6 5 0,000 0,02839511 0,09663173 ! peroxisome fission GO:0016559 5 5 0,000 0,02839511 0,09649524 ! histone demethylation GO:0016577 10 5 0,000 0,02839511 0,09635914 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02839511 0,09622342 ! mitotic recombination GO:0006312 9 5 0,000 0,02839511 0,09608809 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02839511 0,09595313 ! metaphase plate congression GO:0051310 7 5 0,000 0,02839511 0,09581856 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02839511 0,09568436 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02839511 0,09555053 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02839511 0,09541708 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02839511 0,095284 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02839511 0,0951513 ! muscle cell proliferation GO:0033002 11 5 0,000 0,02839511 0,09501896 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02839511 0,09488699 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,02839511 0,09475538 ! plasminogen activation GO:0031639 5 5 0,000 0,02839511 0,09462414 ! B cell homeostasis GO:0001782 13 5 0,000 0,02839511 0,09449327 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02839511 0,09436275 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02839511 0,09423259 ! metaphase GO:0051323 8 5 0,000 0,02839511 0,0941028 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02839511 0,09397336 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02839511 0,09384427 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02839511 0,09371554 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02839511 0,09358717 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02839511 0,09345914 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02839511 0,09333146 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02839511 0,09320414 ! response to redox state GO:0051775 5 5 0,000 0,02839511 0,09307715 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02839511 0,09295052 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02839511 0,09282423 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02839511 0,09269828 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02839511 0,09257267 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02839511 0,0924474 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02839511 0,09232247 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02839511 0,09219788 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02839511 0,09207363 ! striatum development GO:0021756 9 5 0,000 0,02839511 0,09194971 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,02839511 0,09182612 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02839511 0,09170286 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02839511 0,09157993 ! glial cell migration GO:0008347 11 5 0,000 0,02839511 0,09145734 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02839511 0,09133507 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,02839511 0,09121313 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02839511 0,09109151 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02839511 0,09097021 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02839511 0,09084924 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02839511 0,09072859 ! neuroprotection GO:0043526 6 5 0,000 0,02839511 0,09060826 ! neural plate development GO:0001840 8 5 0,000 0,02839511 0,09048825 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02839511 0,09036856 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02839511 0,09024918 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02839511 0,09013012 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02839511 0,09001137 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02839511 0,08989294 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02839511 0,08977481 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02839511 0,089657 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02839511 0,08953949 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02839511 0,08942229 ! spindle assembly GO:0051225 6 5 0,000 0,02839511 0,0893054 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02839511 0,08918881 GO:0016226|iron-sulfur cluster assembly, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02839511 0,08907253 ! drug metabolic process GO:0017144 6 5 0,000 0,02839511 0,08895655 ! stem cell division GO:0017145 11 5 0,000 0,02839511 0,08884087 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,02839511 0,08872549 ! organ regeneration GO:0031100 7 5 0,000 0,02839511 0,08861042 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02839511 0,08849564 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02839511 0,08838115 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02839511 0,08826697 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 1,000 0,0287835 0,08935883 ! epidermal cell differentiation GO:0009913 68 46 1,000 0,0287835 0,08924368 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,02995126 0,09274482 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,02995126 0,09262561 ! positive regulation of cyclase activity GO:0031281 103 47 1,000 0,02995126 0,09250671 ! cellular component disassembly GO:0022411 86 48 1,000 0,03113762 0,09604759 ! regulation of ARF protein signal transduction GO:0032012 102 48 1,000 0,03113762 0,09592461 ! activation of caspase activity GO:0006919 84 48 1,000 0,03113762 0,09580194 ! positive regulation of lyase activity GO:0051349 104 48 1,000 0,03113762 0,09567959 ! regulation of lymphocyte differentiation GO:0045619 81 48 1,000 0,03113762 0,09555755 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,03234234 0,09912823 ! peptide metabolic process GO:0006518 76 49 1,000 0,03234234 0,09900211 ! response to temperature stimulus GO:0009266 76 49 1,000 0,03234234 0,09887632 ! endocrine system development GO:0035270 104 49 1,000 0,03234234 0,09875084 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,03234234 0,09862568 ! regulation of ossification GO:0030278 117 50 1,000 0,03356515 0,10222502 ! histone modification GO:0016570 91 50 1,000 0,03356515 0,10209578 ! negative regulation of immune system process GO:0002683 95 50 1,000 0,03356515 0,10196687 ! positive regulation of cytokine production GO:0001819 86 50 1,000 0,03356515 0,10183829 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03397719 0,10295859 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03397719 0,10282908 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,03397719 0,1026999 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03397719 0,10257104 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03397719 0,10244251 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,03397719 0,10231429 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,03397719 0,1021864 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03397719 0,10205883 ! sleep GO:0030431 13 6 0,000 0,03397719 0,10193157 ! response to oxygen radical GO:0000305 11 6 0,000 0,03397719 0,10180463 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,03397719 0,10167801 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,03397719 0,1015517 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,03397719 0,10142571 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,03397719 0,10130002 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03397719 0,10117465 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,03397719 0,10104959 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03397719 0,10092484 ! male meiosis GO:0007140 7 6 0,000 0,03397719 0,10080039 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03397719 0,10067626 ! response to zinc ion GO:0010043 9 6 0,000 0,03397719 0,10055242 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03397719 0,10042889 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,03397719 0,10030567 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03397719 0,10018274 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03397719 0,10006012 ! malate metabolic process GO:0006108 11 6 0,000 0,03397719 0,0999378 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,03397719 0,09981578 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,03397719 0,09969405 ! protein refolding GO:0042026 15 6 0,000 0,03397719 0,09957262 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03397719 0,09945148 ! opsonization GO:0008228 8 6 0,000 0,03397719 0,09933064 ! mating behavior GO:0007617 7 6 0,000 0,03397719 0,0992101 ! neuron remodeling GO:0016322 15 6 0,000 0,03397719 0,09908984 ! erythrocyte maturation GO:0043249 7 6 0,000 0,03397719 0,09896988 ! equilibrioception GO:0050957 14 6 0,000 0,03397719 0,09885021 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,03397719 0,09873082 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,03397719 0,09861172 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03397719 0,09849292 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,03397719 0,09837439 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03397719 0,09825615 ! response to interferon-gamma GO:0034341 15 6 0,000 0,03397719 0,0981382 ! toxin metabolic process GO:0009404 11 6 0,000 0,03397719 0,09802053 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03397719 0,09790314 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03397719 0,09778603 ! nuclear migration GO:0007097 12 6 0,000 0,03397719 0,0976692 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,03397719 0,09755265 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,03397719 0,09743638 ! thymic T cell selection GO:0045061 12 6 0,000 0,03397719 0,09732038 ! protein lipoylation GO:0009249 10 6 0,000 0,03397719 0,09720466 ! cysteine metabolic process GO:0006534 10 6 0,000 0,03397719 0,09708922 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03397719 0,09697404 ! glutamate catabolic process GO:0006538 10 6 0,000 0,03397719 0,09685915 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,03397719 0,09674452 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03397719 0,09663017 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,03397719 0,09651608 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,03397719 0,09640226 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03397719 0,09628872 ! hyperosmotic response GO:0006972 9 6 0,000 0,03397719 0,09617544 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,03397719 0,09606242 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,03397719 0,09594967 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03397719 0,09583719 ! urea metabolic process GO:0019627 7 6 0,000 0,03397719 0,09572496 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03397719 0,09561301 ! neutrophil activation GO:0042119 8 6 0,000 0,03397719 0,09550131 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03397719 0,09538987 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,03397719 0,09527869 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03397719 0,09516778 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03397719 0,09505712 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03397719 0,09494671 ! neuron apoptosis GO:0051402 9 6 0,000 0,03397719 0,09483657 ! nucleoside salvage GO:0043174 9 6 0,000 0,03397719 0,09472667 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,03397719 0,09461704 ! T cell mediated immunity GO:0002456 16 6 0,000 0,03397719 0,09450765 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03397719 0,09439852 GO:0010543|regulation of platelet activation, ! carnitine transport GO:0015879 10 6 0,000 0,03397719 0,09428964 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,03397719 0,09418101 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03397719 0,09407264 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,03397719 0,09396451 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,03397719 0,09385662 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,03397719 0,09374899 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03397719 0,0936416 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,03397719 0,09353446 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,03397719 0,09342757 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,03397719 0,09332091 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,03397719 0,0932145 ! monocyte differentiation GO:0030224 12 6 0,000 0,03397719 0,09310834 ! response to UV-C GO:0010225 11 6 0,000 0,03397719 0,09300241 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,03397719 0,09289673 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03397719 0,09279128 ! interaction with symbiont GO:0051702 13 6 0,000 0,03397719 0,09268608 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03397719 0,09258111 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03397719 0,09247638 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,03397719 0,09237189 ! response to copper ion GO:0046688 10 6 0,000 0,03397719 0,09226763 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,03397719 0,09216361 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,03397719 0,09205982 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03397719 0,09195627 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03397719 0,09185294 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03397719 0,09174985 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,03397719 0,091647 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03397719 0,09154437 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,03397719 0,09144197 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03397719 0,0913398 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,03397719 0,09123786 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03397719 0,09113614 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,03397719 0,09103465 ! subpallium development GO:0021544 10 6 0,000 0,03397719 0,09093339 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,03397719 0,09083236 ! histone ubiquitination GO:0016574 8 6 0,000 0,03397719 0,09073154 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,03397719 0,09063095 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03397719 0,09053059 ! G2 phase GO:0051319 16 6 0,000 0,03397719 0,09043044 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,03397719 0,09033052 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03397719 0,09023082 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,03397719 0,09013133 ! membrane to membrane docking GO:0022614 14 6 0,000 0,03397719 0,09003207 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03397719 0,08993303 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,03397719 0,0898342 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03397719 0,08973559 ! receptor internalization GO:0031623 10 6 0,000 0,03397719 0,08963719 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,03397719 0,08953901 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,03397719 0,08944105 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03397719 0,0893433 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,03397719 0,08924576 ! protein deubiquitination GO:0016579 14 6 0,000 0,03397719 0,08914844 ! protein destabilization GO:0031648 9 6 0,000 0,03397719 0,08905133 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,03397719 0,08895443 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03397719 0,08885774 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,03397719 0,08876126 ! progesterone metabolic process GO:0042448 10 6 0,000 0,03397719 0,08866499 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,03397719 0,08856893 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,03397719 0,08847307 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,03397719 0,08837743 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03397719 0,08828199 ! determination of adult lifespan GO:0008340 15 6 0,000 0,03397719 0,08818675 ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,03397719 0,08809172 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03397719 0,0879969 ! catecholamine transport GO:0051937 9 6 0,000 0,03397719 0,08790228 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,03397719 0,08780786 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03397719 0,08771365 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03397719 0,08761964 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,03397719 0,08752582 ! maternal placenta development GO:0001893 12 6 0,000 0,03397719 0,08743221 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,03397719 0,0873388 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03397719 0,08724559 ! negative regulation of B cell activation GO:0050869 13 6 0,000 0,03397719 0,08715258 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,03397719 0,08705977 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03397719 0,08696715 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,03397719 0,08687473 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,03397719 0,08678251 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 1,000 0,03480583 0,0888047 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 0,03480583 0,08871063 ! membrane fusion GO:0006944 110 52 1,000 0,03606413 0,09182041 ! covalent chromatin modification GO:0016569 101 52 1,000 0,03606413 0,09172335 ! morphogenesis of a branching structure GO:0001763 111 52 1,000 0,03606413 0,09162649 ! amino acid activation GO:0043038 92 52 1,000 0,03606413 0,09152984 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! synapse organization GO:0050808 85 52 1,000 0,03606413 0,09143339 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,0386326 0,09784215 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,0386326 0,09773926 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 1,000 0,0386326 0,0976366 ! tRNA transcription GO:0009304 14 7 0,000 0,03952739 0,09979317 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03952739 0,09968856 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03952739 0,09958418 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03952739 0,09948001 ! regulation of helicase activity GO:0051095 15 7 0,000 0,03952739 0,09937606 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,03952739 0,09927233 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03952739 0,09916881 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03952739 0,09906551 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03952739 0,09896243 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03952739 0,09885955 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03952739 0,0987569 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03952739 0,09865445 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03952739 0,09855222 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03952739 0,0984502 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03952739 0,09834839 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03952739 0,09824679 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,03952739 0,0981454 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03952739 0,09804422 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03952739 0,09794325 ! glycolipid transport GO:0046836 10 7 0,000 0,03952739 0,09784248 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03952739 0,09774192 GO:0051923|sulfation, ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03952739 0,09764157 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03952739 0,09754143 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03952739 0,09744149 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03952739 0,09734175 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03952739 0,09724222 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03952739 0,09714289 ! pericardium development GO:0060039 14 7 0,000 0,03952739 0,09704377 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03952739 0,09694484 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03952739 0,09684612 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03952739 0,0967476 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03952739 0,09664928 ! lipoprotein transport GO:0042953 14 7 0,000 0,03952739 0,09655116 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03952739 0,09645324 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03952739 0,09635551 ! rhythmic behavior GO:0007622 15 7 0,000 0,03952739 0,09625799 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03952739 0,09616066 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03952739 0,09606353 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03952739 0,09596659 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03952739 0,09586985 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03952739 0,0957733 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03952739 0,09567695 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03952739 0,09558079 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03952739 0,09548483 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03952739 0,09538906 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03952739 0,09529348 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03952739 0,09519809 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03952739 0,09510289 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03952739 0,09500788 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,03952739 0,09491306 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03952739 0,09481844 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03952739 0,09472399 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03952739 0,09462974 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03952739 0,09453568 ! ovulation GO:0030728 9 7 0,000 0,03952739 0,0944418 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03952739 0,09434811 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03952739 0,0942546 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03952739 0,09416128 ! microtubule nucleation GO:0007020 20 7 0,000 0,03952739 0,09406814 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03952739 0,09397519 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03952739 0,09388242 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,03952739 0,09378983 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03952739 0,09369743 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03952739 0,09360521 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03952739 0,09351317 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03952739 0,09342131 ! galactose metabolic process GO:0006012 13 7 0,000 0,03952739 0,09332963 ! vesicle fusion GO:0006906 17 7 0,000 0,03952739 0,09323813 ! response to dietary excess GO:0002021 8 7 0,000 0,03952739 0,09314681 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03952739 0,09305567 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03952739 0,0929647 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03952739 0,09287392 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03952739 0,09278331 ! organ growth GO:0035265 15 7 0,000 0,03952739 0,09269288 ! purine salvage GO:0043101 10 7 0,000 0,03952739 0,09260262 ! nucleoside transport GO:0015858 8 7 0,000 0,03952739 0,09251254 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03952739 0,09242263 ! parturition GO:0007567 14 7 0,000 0,03952739 0,0923329 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,03952739 0,09224335 ! rRNA modification GO:0000154 14 7 0,000 0,03952739 0,09215396 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03952739 0,09206475 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03952739 0,09197572 ! macrophage differentiation GO:0030225 11 7 0,000 0,03952739 0,09188685 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03952739 0,09179816 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03952739 0,09170963 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,03952739 0,09162128 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03952739 0,0915331 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,03952739 0,09144509 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03952739 0,09135724 ! fibrinolysis GO:0042730 10 7 0,000 0,03952739 0,09126957 ! eating behavior GO:0042755 7 7 0,000 0,03952739 0,09118206 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03952739 0,09109472 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03952739 0,09100755 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03952739 0,09092055 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03952739 0,09083371 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03952739 0,09074703 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03952739 0,09066053 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03952739 0,09057418 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03952739 0,090488 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03952739 0,09040199 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03952739 0,09031614 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03952739 0,09023045 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03952739 0,09014492 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03952739 0,09005956 ! regulation of meiosis GO:0040020 12 7 0,000 0,03952739 0,08997435 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03952739 0,08988931 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03952739 0,08980443 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,03952739 0,08971971 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03952739 0,08963515 ! transcription termination GO:0006353 13 7 0,000 0,03952739 0,08955074 ! response to tumor cell GO:0002347 13 7 0,000 0,03952739 0,0894665 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03952739 0,08938242 ! anaphase GO:0051322 17 7 0,000 0,03952739 0,08929849 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,03952739 0,08921472 ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03952739 0,08913111 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,03952739 0,08904765 ! diuresis GO:0030146 12 7 0,000 0,03952739 0,08896435 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03952739 0,08888121 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03952739 0,08879822 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03952739 0,08871538 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03952739 0,0886327 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03952739 0,08855018 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03952739 0,08846781 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03952739 0,08838559 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03952739 0,08830352 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03952739 0,08822161 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03952739 0,08813984 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03952739 0,08805823 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03952739 0,08797677 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03952739 0,08789546 ! lymph node development GO:0048535 10 7 0,000 0,03952739 0,0878143 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,03952739 0,08773329 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03952739 0,08765243 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,03952739 0,08757172 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03952739 0,08749116 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03952739 0,08741075 ! adult feeding behavior GO:0008343 9 7 0,000 0,03952739 0,08733048 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03952739 0,08725036 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03952739 0,08717039 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03952739 0,08709056 ! muscle adaptation GO:0043500 14 7 0,000 0,03952739 0,08701088 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03952739 0,08693134 ! retina homeostasis GO:0001895 12 7 0,000 0,03952739 0,08685196 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03952739 0,08677271 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03952739 0,08669361 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,03952739 0,08661465 ! protein prenylation GO:0018342 18 7 0,000 0,03952739 0,08653584 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,03952739 0,08645717 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,03952739 0,08637865 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03952739 0,08630026 ! positive regulation of caspase activity GO:0043280 95 55 1,000 0,03994231 0,0871271 GO:0010952|positive regulation of peptidase activity, ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,03994231 0,08704818 ! gastrulation GO:0007369 112 55 1,000 0,03994231 0,0869694 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,04126868 0,08977617 ! regulation of DNA replication GO:0006275 101 56 1,000 0,04126868 0,08969507 ! muscle fiber development GO:0048747 112 57 1,000 0,04261149 0,09252999 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,04261149 0,09244656 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,04397049 0,09530902 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,04504588 0,0975521 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,04504588 0,09746437 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,04504588 0,0973768 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,04504588 0,09728939 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04504588 0,09720213 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04504588 0,09711504 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,04504588 0,09702809 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,04504588 0,09694131 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,04504588 0,09685467 ! meiotic prophase I GO:0007128 13 8 0,000 0,04504588 0,0967682 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04504588 0,09668187 ! oligopeptide transport GO:0006857 15 8 0,000 0,04504588 0,0965957 ! UTP metabolic process GO:0046051 8 8 0,000 0,04504588 0,09650969 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,04504588 0,09642383 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,04504588 0,09633812 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,04504588 0,09625256 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04504588 0,09616715 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04504588 0,0960819 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,04504588 0,09599679 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,04504588 0,09591184 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04504588 0,09582704 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04504588 0,09574239 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,04504588 0,09565788 ! reflex GO:0060004 16 8 0,000 0,04504588 0,09557353 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,04504588 0,09548932 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,04504588 0,09540526 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04504588 0,09532135 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,04504588 0,09523759 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,04504588 0,09515398 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04504588 0,09507051 ! pigment granule organization GO:0048753 16 8 0,000 0,04504588 0,09498719 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04504588 0,09490401 ! histidine metabolic process GO:0006547 16 8 0,000 0,04504588 0,09482098 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04504588 0,09473809 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,04504588 0,09465535 ! glycine catabolic process GO:0006546 13 8 0,000 0,04504588 0,09457276 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,04504588 0,09449031 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,04504588 0,094408 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,04504588 0,09432583 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,04504588 0,09424381 ! melanin metabolic process GO:0006582 15 8 0,000 0,04504588 0,09416193 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,04504588 0,09408019 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04504588 0,0939986 ! macrophage activation GO:0042116 12 8 0,000 0,04504588 0,09391714 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04504588 0,09383583 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,04504588 0,09375465 ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,04504588 0,09367362 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04504588 0,09359273 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,04504588 0,09351198 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,04504588 0,09343136 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,04504588 0,09335089 ! osteoblast development GO:0002076 16 8 0,000 0,04504588 0,09327055 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,04504588 0,09319035 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,04504588 0,09311029 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,04504588 0,09303037 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,04504588 0,09295058 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04504588 0,09287093 ! response to UV-B GO:0010224 16 8 0,000 0,04504588 0,09279142 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,04504588 0,09271204 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04504588 0,0926328 ! intermediate filament organization GO:0045109 12 8 0,000 0,04504588 0,0925537 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,04504588 0,09247473 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,04504588 0,09239589 ! cellular extravasation GO:0045123 12 8 0,000 0,04504588 0,09231719 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,04504588 0,09223862 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,04504588 0,09216019 ! response to antibiotic GO:0046677 11 8 0,000 0,04504588 0,09208189 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,04504588 0,09200372 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,04504588 0,09192568 ! response to tropane GO:0014073 15 8 0,000 0,04504588 0,09184778 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,04504588 0,09177001 ! melanosome transport GO:0032402 13 8 0,000 0,04504588 0,09169237 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,04504588 0,09161486 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04504588 0,09153748 ! mast cell activation GO:0045576 14 8 0,000 0,04504588 0,09146024 ! multicellular organismal aging GO:0010259 18 8 0,000 0,04504588 0,09138312 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,04504588 0,09130613 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,04504588 0,09122928 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,04504588 0,09115255 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04504588 0,09107595 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04504588 0,09099948 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,04504588 0,09092314 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04504588 0,09084692 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04504588 0,09077084 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,04504588 0,09069488 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,04504588 0,09061905 ! intracellular lipid transport GO:0032365 13 8 0,000 0,04504588 0,09054334 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04504588 0,09046776 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04504588 0,09039231 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,04504588 0,09031698 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,04504588 0,09024178 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04504588 0,09016671 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,04504588 0,09009175 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,04504588 0,09001693 ! hormone catabolic process GO:0042447 17 8 0,000 0,04504588 0,08994222 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04504588 0,08986765 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,04504588 0,08979319 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,04504588 0,08971886 ! ATP catabolic process GO:0006200 11 8 0,000 0,04504588 0,08964465 ! blastocyst growth GO:0001832 19 8 0,000 0,04504588 0,08957056 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04504588 0,0894966 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04504588 0,08942276 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,04504588 0,08934904 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04504588 0,08927544 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04504588 0,08920196 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,04504588 0,0891286 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,04504588 0,08905537 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,04504588 0,08898225 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,04504588 0,08890925 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,04504588 0,08883638 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,04504588 0,08876362 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04504588 0,08869098 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,04504588 0,08861846 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04504588 0,08854606 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04504588 0,08847378 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,04504588 0,08840162 ! cytokine-mediated signaling pathway GO:0019221 97 59 1,000 0,04534548 0,08891705 ! integrin-mediated signaling pathway GO:0007229 135 59 1,000 0,04534548 0,08884464 ! establishment of organelle localization GO:0051656 109 59 1,000 0,04534548 0,08877235 ! regulation of neurotransmitter levels GO:0001505 97 60 1,000 0,04673621 0,09142059 ! ear development GO:0043583 103 62 1,000 0,04956404 0,09687333 ! viral reproductive process GO:0022415 126 62 1,000 0,04956404 0,0967947 ! axon extension GO:0048675 15 9 0,000 0,05053284 0,09860667 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,05053284 0,09852676 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,05053284 0,09844698 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,05053284 0,09836733 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05053284 0,09828781 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,05053284 0,09820842 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,05053284 0,09812915 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,05053284 0,09805002 ! phosphate transport GO:0006817 19 9 0,000 0,05053284 0,09797101 ! reproductive behavior GO:0019098 19 9 0,000 0,05053284 0,09789213 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05053284 0,09781337 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,05053284 0,09773474 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05053284 0,09765624 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,05053284 0,09757787 ! GTP metabolic process GO:0046039 9 9 0,000 0,05053284 0,09749962 ! RNA methylation GO:0001510 15 9 0,000 0,05053284 0,09742149 ! elastic fiber assembly GO:0048251 15 9 0,000 0,05053284 0,09734349 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,05053284 0,09726562 ! regulation of histone modification GO:0031056 12 9 0,000 0,05053284 0,09718787 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,05053284 0,09711024 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,05053284 0,09703274 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,05053284 0,09695536 ! chemosensory behavior GO:0007635 20 9 0,000 0,05053284 0,0968781 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,05053284 0,09680097 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05053284 0,09672396 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,05053284 0,09664708 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,05053284 0,09657031 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,05053284 0,09649367 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05053284 0,09641715 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05053284 0,09634075 ! protein targeting to ER GO:0045047 22 9 0,000 0,05053284 0,09626447 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,05053284 0,09618831 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,05053284 0,09611227 ! T cell selection GO:0045058 23 9 0,000 0,05053284 0,09603635 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,05053284 0,09596055 ! endosome organization GO:0007032 17 9 0,000 0,05053284 0,09588487 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05053284 0,09580931 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05053284 0,09573387 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05053284 0,09565855 ! mannose metabolic process GO:0006013 13 9 0,000 0,05053284 0,09558335 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,05053284 0,09550826 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,05053284 0,0954333 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,05053284 0,09535845 ! receptor clustering GO:0043113 18 9 0,000 0,05053284 0,09528372 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,05053284 0,0952091 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05053284 0,0951346 ! ruffle organization GO:0031529 15 9 0,000 0,05053284 0,09506022 ! retinol metabolic process GO:0042572 18 9 0,000 0,05053284 0,09498595 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,05053284 0,0949118 ! behavioral fear response GO:0001662 22 9 0,000 0,05053284 0,09483777 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,05053284 0,09476385 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,05053284 0,09469005 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,05053284 0,09461636 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,05053284 0,09454278 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,05053284 0,09446932 ! segment specification GO:0007379 13 9 0,000 0,05053284 0,09439598 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05053284 0,09432275 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,05053284 0,09424963 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05053284 0,09417662 ! response to amine stimulus GO:0014075 13 9 0,000 0,05053284 0,09410373 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05053284 0,09403095 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,05053284 0,09395828 ! erythrocyte development GO:0048821 15 9 0,000 0,05053284 0,09388573 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05053284 0,09381329 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,05053284 0,09374096 ! renal water homeostasis GO:0003091 14 9 0,000 0,05053284 0,09366874 ! postreplication repair GO:0006301 22 9 0,000 0,05053284 0,09359663 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,05053284 0,09352463 ! icosanoid secretion GO:0032309 15 9 0,000 0,05053284 0,09345274 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,05053284 0,09338097 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05053284 0,0933093 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,05053284 0,09323775 ! regulation of cell division GO:0051302 15 9 0,000 0,05053284 0,0931663 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,05053284 0,09309496 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,05053284 0,09302373 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05053284 0,09295262 ! sterol catabolic process GO:0016127 11 9 0,000 0,05053284 0,0928816 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05053284 0,0928107 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,05053284 0,09273991 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,05053284 0,09266922 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,05053284 0,09259864 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,05053284 0,09252817 ! musculoskeletal movement GO:0050881 14 9 0,000 0,05053284 0,09245781 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,05053284 0,09238755 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,05053284 0,0923174 ! purine base metabolic process GO:0006144 21 9 0,000 0,05053284 0,09224736 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,05053284 0,09217742 ! pigment granule transport GO:0051904 17 9 0,000 0,05053284 0,09210759 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,05053284 0,09203787 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,05053284 0,09196825 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05053284 0,09189873 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05053284 0,09182932 ! mitochondrion localization GO:0051646 15 9 0,000 0,05053284 0,09176002 ! detection of external stimulus GO:0009581 91 63 1,000 0,05100068 0,0925397 ! regulation of cytokine biosynthetic process GO:0042035 95 65 1,000 0,05391836 0,09776004 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,05391836 0,09768642 GO:0035113|embryonic appendage morphogenesis, ! extracellular matrix organization GO:0030198 133 66 1,000 0,05539896 0,10029337 ! developmental maturation GO:0021700 116 66 1,000 0,05539896 0,10021796 ! cell projection assembly GO:0030031 120 66 1,000 0,05539896 0,10014267 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,05598846 0,10113231 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05598846 0,10105645 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,05598846 0,10098069 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05598846 0,10090505 ! synapsis GO:0007129 13 10 0,000 0,05598846 0,10082952 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,05598846 0,10075411 ! N-glycan processing GO:0006491 20 10 0,000 0,05598846 0,10067881 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,05598846 0,10060362 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,05598846 0,10052854 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,05598846 0,10045357 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,05598846 0,10037872 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,05598846 0,10030398 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 17 10 0,000 0,05598846 0,10022935 ! phospholipid efflux GO:0033700 16 10 0,000 0,05598846 0,10015483 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05598846 0,10008042 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,05598846 0,10000612 ! pathogenesis GO:0009405 13 10 0,000 0,05598846 0,09993193 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05598846 0,09985785 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,05598846 0,09978388 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,05598846 0,09971002 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,05598846 0,09963627 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,05598846 0,09956263 ! endoderm development GO:0007492 16 10 0,000 0,05598846 0,0994891 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,05598846 0,09941568 ! arginine catabolic process GO:0006527 13 10 0,000 0,05598846 0,09934236 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05598846 0,09926915 ! proline metabolic process GO:0006560 13 10 0,000 0,05598846 0,09919606 ! L-serine metabolic process GO:0006563 18 10 0,000 0,05598846 0,09912306 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,05598846 0,09905018 ! V(D)J recombination GO:0033151 28 10 0,000 0,05598846 0,0989774 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05598846 0,09890473 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,05598846 0,09883217 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,05598846 0,09875971 ! B cell proliferation GO:0042100 18 10 0,000 0,05598846 0,09868736 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,05598846 0,09861511 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,05598846 0,09854297 ! multicellular organism growth GO:0035264 18 10 0,000 0,05598846 0,09847094 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,05598846 0,09839901 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,05598846 0,09832718 ! epithelial cell development GO:0002064 20 10 0,000 0,05598846 0,09825547 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,05598846 0,09818385 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05598846 0,09811234 ! macroautophagy GO:0016236 17 10 0,000 0,05598846 0,09804093 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,05598846 0,09796963 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,05598846 0,09789843 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,05598846 0,09782734 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 0,000 0,05598846 0,09775634 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05598846 0,09768546 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,05598846 0,09761467 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,05598846 0,09754398 ! blastoderm segmentation GO:0007350 18 10 0,000 0,05598846 0,0974734 ! response to dsRNA GO:0043331 20 10 0,000 0,05598846 0,09740292 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05598846 0,09733255 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05598846 0,09726227 ! melanosome localization GO:0032400 16 10 0,000 0,05598846 0,09719209 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,05598846 0,09712202 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,05598846 0,09705205 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,05598846 0,09698218 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05598846 0,09691241 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,05598846 0,09684273 ! mRNA cleavage GO:0006379 17 10 0,000 0,05598846 0,09677316 ! protein sumoylation GO:0016925 15 10 0,000 0,05598846 0,09670369 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05598846 0,09663432 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05598846 0,09656505 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,05598846 0,09649588 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,05598846 0,0964268 ! salivary gland development GO:0007431 27 10 0,000 0,05598846 0,09635783 ! prophase GO:0051324 15 10 0,000 0,05598846 0,09628895 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05598846 0,09622017 ! apical protein localization GO:0045176 15 10 0,000 0,05598846 0,09615149 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,05598846 0,09608291 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,05598846 0,09601443 ! midbrain development GO:0030901 13 10 0,000 0,05598846 0,09594604 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05598846 0,09587775 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,05598846 0,09580956 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,05598846 0,09574147 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,05598846 0,09567347 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05598846 0,09560557 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05598846 0,09553776 ! detection of calcium ion GO:0005513 23 10 0,000 0,05598846 0,09547005 ! oocyte development GO:0048599 17 10 0,000 0,05598846 0,09540244 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05598846 0,09533492 ! blastocyst formation GO:0001825 17 10 0,000 0,05598846 0,0952675 ! cerebellar cortex development GO:0021695 15 10 0,000 0,05598846 0,09520017 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,05598846 0,09513294 ! activation of innate immune response GO:0002218 12 10 0,000 0,05598846 0,0950658 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,05598846 0,09499876 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,05598846 0,09493181 ! response to nicotine GO:0035094 20 10 0,000 0,05598846 0,09486496 ! establishment of cell polarity GO:0030010 16 10 0,000 0,05598846 0,0947982 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,05598846 0,09473154 ! negative regulation of cell growth GO:0030308 132 67 1,000 0,05689378 0,09619567 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 1,000 0,05689378 0,09612811 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,05689378 0,09606066 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,05689378 0,09599329 ! adaptive immune response GO:0002250 119 67 1,000 0,05689378 0,09592602 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,05840262 0,09840104 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 134 68 1,000 0,05840262 0,09833218 ! regulation of lipase activity GO:0060191 130 68 1,000 0,05840262 0,09826342 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,05992526 0,10075483 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,06141292 0,10318399 ! respiratory burst GO:0045730 17 11 0,000 0,06141292 0,10311199 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,06141292 0,10304008 ! telencephalon cell migration GO:0022029 20 11 0,000 0,06141292 0,10296828 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,06141292 0,10289657 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,06141292 0,10282497 ! thyroid gland development GO:0030878 26 11 0,000 0,06141292 0,10275346 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,06141292 0,10268205 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,06141292 0,10261075 ! response to pain GO:0048265 24 11 0,000 0,06141292 0,10253954 ! T cell proliferation GO:0042098 26 11 0,000 0,06141292 0,10246843 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 0,000 0,06141292 0,10239742 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,06141292 0,10232651 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06141292 0,10225569 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06141292 0,10218498 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,06141292 0,10211436 ! melanocyte differentiation GO:0030318 21 11 0,000 0,06141292 0,10204384 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,06141292 0,10197341 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,06141292 0,10190309 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,06141292 0,10183286 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,06141292 0,10176272 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,06141292 0,10169269 ! lipid digestion GO:0044241 18 11 0,000 0,06141292 0,10162275 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,06141292 0,1015529 ! UV protection GO:0009650 19 11 0,000 0,06141292 0,10148316 ! adult heart development GO:0007512 14 11 0,000 0,06141292 0,1014135 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06141292 0,10134395 ! temperature homeostasis GO:0001659 17 11 0,000 0,06141292 0,10127449 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,06141292 0,10120512 ! negative regulation of ossification GO:0030279 26 11 0,000 0,06141292 0,10113585 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,06141292 0,10106667 ! regulation of organ growth GO:0046620 13 11 0,000 0,06141292 0,10099759 ! pigment granule localization GO:0051875 20 11 0,000 0,06141292 0,1009286 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,06141292 0,10085971 ! vasoconstriction GO:0042310 18 11 0,000 0,06141292 0,10079091 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06141292 0,10072221 ! embryonic axis specification GO:0000578 18 11 0,000 0,06141292 0,10065359 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,06141292 0,10058508 ! snRNA metabolic process GO:0016073 24 11 0,000 0,06141292 0,10051665 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06141292 0,10044832 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,06141292 0,10038008 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,06141292 0,10031193 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,06141292 0,10024388 ! zymogen activation GO:0031638 15 11 0,000 0,06141292 0,10017592 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,06141292 0,10010805 ! neuroblast proliferation GO:0007405 24 11 0,000 0,06141292 0,10004027 ! nucleosome positioning GO:0016584 15 11 0,000 0,06141292 0,09997258 ! regulation of isotype switching GO:0045191 22 11 0,000 0,06141292 0,09990499 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,06141292 0,09983748 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,06141292 0,09977007 ! acid secretion GO:0046717 18 11 0,000 0,06141292 0,09970275 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06141292 0,09963552 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,06141292 0,09956838 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,06141292 0,09950133 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,06141292 0,09943437 ! oocyte differentiation GO:0009994 18 11 0,000 0,06141292 0,0993675 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,06141292 0,09930072 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,06141292 0,09923403 ! cholesterol efflux GO:0033344 19 11 0,000 0,06141292 0,09916743 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,06141292 0,09910092 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06141292 0,0990345 ! germ cell migration GO:0008354 25 11 0,000 0,06141292 0,09896817 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,06141292 0,09890193 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,06141292 0,09883577 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,06141292 0,0987697 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,06141292 0,09870373 ! defense response to fungus GO:0050832 13 11 0,000 0,06141292 0,09863783 ! developmental induction GO:0031128 19 11 0,000 0,06141292 0,09857203 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,06141292 0,09850632 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06141292 0,09844069 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,06141292 0,09837515 ! sequestering of metal ion GO:0051238 14 11 0,000 0,06141292 0,0983097 ! lamellipodium assembly GO:0030032 20 11 0,000 0,06141292 0,09824433 ! nucleus localization GO:0051647 19 11 0,000 0,06141292 0,09817905 ! appendage morphogenesis GO:0035107 135 70 1,000 0,0614615 0,09819147 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 136 71 1,000 0,06301113 0,10060039 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 1,000 0,06301113 0,10053367 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,06301113 0,10046705 ! regulation of immune effector process GO:0002697 137 71 1,000 0,06301113 0,10040052 ! acute inflammatory response GO:0002526 113 72 1,000 0,06457396 0,1028226 ! regulation of caspase activity GO:0043281 122 72 1,000 0,06457396 0,10275459 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,06457396 0,10268668 ! carbohydrate transport GO:0008643 110 72 1,000 0,06457396 0,10261885 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,06457396 0,10255112 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,06680638 0,10602648 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,06680638 0,10595659 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,06680638 0,10588679 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,06680638 0,10581708 ! cartilage condensation GO:0001502 20 12 0,000 0,06680638 0,10574746 ! mating GO:0007618 17 12 0,000 0,06680638 0,10567794 ! protein complex disassembly GO:0043241 27 12 0,000 0,06680638 0,10560851 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06680638 0,10553916 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,06680638 0,10546991 ! hippocampus development GO:0021766 26 12 0,000 0,06680638 0,10540075 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,06680638 0,10533168 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06680638 0,1052627 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,06680638 0,10519381 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,06680638 0,10512501 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,06680638 0,1050563 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,06680638 0,10498769 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,06680638 0,10491916 ! drug transport GO:0015893 16 12 0,000 0,06680638 0,10485071 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,06680638 0,10478236 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,06680638 0,1047141 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,06680638 0,10464593 ! polyamine metabolic process GO:0006595 17 12 0,000 0,06680638 0,10457784 ! focal adhesion formation GO:0048041 35 12 0,000 0,06680638 0,10450985 ! mitotic spindle organization GO:0007052 21 12 0,000 0,06680638 0,10444194 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,06680638 0,10437412 ! forebrain cell migration GO:0021885 21 12 0,000 0,06680638 0,10430639 ! asymmetric protein localization GO:0008105 20 12 0,000 0,06680638 0,10423875 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,06680638 0,10417119 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,06680638 0,10410372 ! entry into host cell GO:0030260 32 12 0,000 0,06680638 0,10403634 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 26 12 0,000 0,06680638 0,10396905 ! monoamine transport GO:0015844 18 12 0,000 0,06680638 0,10390184 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06680638 0,10383472 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,06680638 0,10376769 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,06680638 0,10370074 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,06680638 0,10363388 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06680638 0,1035671 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,06680638 0,10350042 ! protein homotetramerization GO:0051289 21 12 0,000 0,06680638 0,10343381 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,06680638 0,1033673 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,06680638 0,10330086 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06680638 0,10323452 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,06680638 0,10316826 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,06680638 0,10310208 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06680638 0,10303599 ! fucose catabolic process GO:0019317 22 12 0,000 0,06680638 0,10296998 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,06680638 0,10290406 ! histone methylation GO:0016571 26 12 0,000 0,06680638 0,10283823 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,06680638 0,10277247 ! gland morphogenesis GO:0022612 29 12 0,000 0,06680638 0,1027068 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,06680638 0,10264122 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,06680638 0,10257572 ! spleen development GO:0048536 22 12 0,000 0,06680638 0,1025103 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,06680638 0,10244496 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,06680638 0,10237971 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,06680638 0,10231454 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,06680638 0,10224946 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,06680638 0,10218445 ! response to cold GO:0009409 17 12 0,000 0,06680638 0,10211953 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,06680638 0,1020547 ! regulation of transcription factor activity GO:0051090 126 74 1,000 0,06773839 0,10341279 GO:0090046|regulation of transcription regulator activity, ! neurotransmitter transport GO:0006836 123 74 1,000 0,06773839 0,10334722 ! meiosis GO:0007126 121 74 1,000 0,06773839 0,10328173 GO:0051327|M phase of meiotic cell cycle, ! exocytosis GO:0006887 133 74 1,000 0,06773839 0,10321632 ! regulation of endopeptidase activity GO:0052548 125 74 1,000 0,06773839 0,10315099 ! organelle localization GO:0051640 136 74 1,000 0,06773839 0,10308575 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,0693396 0,1054558 ! meiotic cell cycle GO:0051321 122 75 1,000 0,0693396 0,10538918 ! steroid biosynthetic process GO:0006694 131 76 1,000 0,0709532 0,10777362 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07216903 0,10955121 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,07216903 0,10948214 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07216903 0,10941315 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,07216903 0,10934425 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,07216903 0,10927544 ! lipid localization GO:0010876 28 13 0,000 0,07216903 0,10920671 GO:0019915|lipid storage, ! organelle fusion GO:0048284 32 13 0,000 0,07216903 0,10913807 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,07216903 0,10906952 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,07216903 0,10900105 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,07216903 0,10893267 ! endocrine pancreas development GO:0031018 22 13 0,000 0,07216903 0,10886437 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,07216903 0,10879616 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,07216903 0,10872804 ! methionine metabolic process GO:0006555 27 13 0,000 0,07216903 0,10866 ! plasma membrane organization GO:0007009 24 13 0,000 0,07216903 0,10859204 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,07216903 0,10852417 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,07216903 0,10845639 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,07216903 0,10838869 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,07216903 0,10832107 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,07216903 0,10825354 ! response to X-ray GO:0010165 25 13 0,000 0,07216903 0,10818609 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,07216903 0,10811873 ! exocrine system development GO:0035272 32 13 0,000 0,07216903 0,10805145 ! negative regulation of mitotic cell cycle GO:0045930 33 13 0,000 0,07216903 0,10798425 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,07216903 0,10791714 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,07216903 0,10785011 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,07216903 0,10778316 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,07216903 0,1077163 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,07216903 0,10764952 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,07216903 0,10758282 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,07216903 0,10751621 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,07216903 0,10744968 ! regulation of cellular pH GO:0030641 22 13 0,000 0,07216903 0,10738323 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07216903 0,10731686 ! ribosome assembly GO:0042255 17 13 0,000 0,07216903 0,10725057 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,07216903 0,10718437 ! chromatin silencing GO:0006342 26 13 0,000 0,07216903 0,10711825 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,07216903 0,1070522 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07216903 0,10698624 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07216903 0,10692037 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,07216903 0,10685457 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,07216903 0,10678885 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07216903 0,10672322 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,07216903 0,10665766 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,07216903 0,10659219 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,07216903 0,10652679 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,07216903 0,10646148 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,07216903 0,10639625 ! insulin secretion GO:0030073 23 13 0,000 0,07216903 0,10633109 ! actin filament polymerization GO:0030041 24 13 0,000 0,07216903 0,10626602 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,07216903 0,10620102 ! acrosome reaction GO:0007340 18 13 0,000 0,07216903 0,10613611 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,07257902 0,10667387 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 1,000 0,07421685 0,1090145 ! protein oligomerization GO:0051259 139 78 1,000 0,07421685 0,10894798 ! regulation of peptidase activity GO:0052547 134 79 1,000 0,07586651 0,11130172 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,07586651 0,11123389 ! rRNA transcription GO:0009303 25 14 0,000 0,07750103 0,1135612 ! lactation GO:0007595 26 14 0,000 0,07750103 0,11349208 ! reproductive cellular process GO:0048610 20 14 0,000 0,07750103 0,11342304 ! tRNA modification GO:0006400 20 14 0,000 0,07750103 0,11335409 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,07750103 0,11328523 ! regulation of S phase GO:0033261 23 14 0,000 0,07750103 0,11321645 ! water transport GO:0006833 21 14 0,000 0,07750103 0,11314775 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,07750103 0,11307913 ! non-recombinational repair GO:0000726 25 14 0,000 0,07750103 0,1130106 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,07750103 0,11294215 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,07750103 0,11287378 ! hair follicle morphogenesis GO:0031069 26 14 0,000 0,07750103 0,1128055 ! RNA polyadenylation GO:0043631 30 14 0,000 0,07750103 0,11273729 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,07750103 0,11266918 ! palate development GO:0060021 31 14 0,000 0,07750103 0,11260114 ! regulated secretory pathway GO:0045055 23 14 0,000 0,07750103 0,11253318 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,07750103 0,11246531 ! arginine metabolic process GO:0006525 17 14 0,000 0,07750103 0,11239752 ! regulation of heart rate GO:0002027 24 14 0,000 0,07750103 0,11232981 ! organic alcohol transport GO:0015850 29 14 0,000 0,07750103 0,11226218 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,07750103 0,11219464 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,07750103 0,11212717 ! embryo implantation GO:0007566 30 14 0,000 0,07750103 0,11205979 ! neutral amino acid transport GO:0015804 26 14 0,000 0,07750103 0,11199248 ! L-amino acid transport GO:0015807 30 14 0,000 0,07750103 0,11192526 ! stem cell development GO:0048864 43 14 0,000 0,07750103 0,11185812 GO:0019827|stem cell maintenance, ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,07750103 0,11179106 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07750103 0,11172408 ! cerebellum development GO:0021549 21 14 0,000 0,07750103 0,11165718 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,07750103 0,11159036 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,07750103 0,11152362 ! response to gamma radiation GO:0010332 28 14 0,000 0,07750103 0,11145695 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,07750103 0,11139037 ! cofactor transport GO:0051181 26 14 0,000 0,07750103 0,11132387 ! NADP metabolic process GO:0006739 24 14 0,000 0,07750103 0,11125745 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,07750103 0,11119111 ! intestinal absorption GO:0050892 25 14 0,000 0,07750103 0,11112484 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,07750103 0,11105866 ! oxygen transport GO:0015671 21 14 0,000 0,07750103 0,11099255 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07750103 0,11092652 ! male genitalia development GO:0030539 24 14 0,000 0,07750103 0,11086057 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,07750103 0,1107947 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,0775278 0,11076716 ! cellular lipid catabolic process GO:0044242 134 80 1,000 0,0775278 0,11070142 ! cell-substrate adhesion GO:0031589 171 81 1,000 0,07920055 0,11302285 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,08088456 0,11535759 ! cholesterol metabolic process GO:0008203 136 82 1,000 0,08088456 0,11528925 ! response to drug GO:0042493 143 82 1,000 0,08088456 0,11522099 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,08088456 0,11515282 ! regulation of lyase activity GO:0051339 160 83 1,000 0,08257966 0,11749655 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08280258 0,11774409 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,08280258 0,11767454 ! superoxide anion generation GO:0042554 20 15 0,000 0,08280258 0,11760507 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,08280258 0,11753569 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,08280258 0,11746639 ! copper ion transport GO:0006825 20 15 0,000 0,08280258 0,11739717 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,08280258 0,11732803 ! sulfate transport GO:0008272 23 15 0,000 0,08280258 0,11725897 ! response to cAMP GO:0051591 22 15 0,000 0,08280258 0,11719 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,08280258 0,1171211 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,08280258 0,11705229 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,08280258 0,11698356 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,08280258 0,1169149 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,08280258 0,11684633 ! response to hexose stimulus GO:0009746 22 15 0,000 0,08280258 0,11677784 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,08280258 0,11670943 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,08280258 0,1166411 ! pituitary gland development GO:0021983 29 15 0,000 0,08280258 0,11657285 ! vesicle coating GO:0006901 33 15 0,000 0,08280258 0,11650468 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,08280258 0,11643658 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,08280258 0,11636857 ! regulation of exocytosis GO:0017157 22 15 0,000 0,08280258 0,11630064 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,08280258 0,11623279 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,08280258 0,11616501 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,08280258 0,11609732 ! regulation of vasodilation GO:0042312 26 15 0,000 0,08280258 0,1160297 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,08280258 0,11596216 ! histone deacetylation GO:0016575 20 15 0,000 0,08280258 0,1158947 ! mRNA splice site selection GO:0006376 38 15 0,000 0,08280258 0,11582732 ! tissue regeneration GO:0042246 26 15 0,000 0,08280258 0,11576002 ! water homeostasis GO:0030104 27 15 0,000 0,08280258 0,1156928 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08280258 0,11562565 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,08280258 0,11555858 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,08280258 0,11549159 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,08280258 0,11542468 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08280258 0,11535784 ! heme biosynthetic process GO:0006783 29 15 0,000 0,08280258 0,11529109 ! cell killing GO:0001906 29 15 0,000 0,08280258 0,1152244 ! detection of bacterium GO:0016045 18 15 0,000 0,08280258 0,1151578 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,08280258 0,11509127 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,08280258 0,11502482 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,08280258 0,11495845 ! peptide hormone processing GO:0016486 23 15 0,000 0,08280258 0,11489215 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,08428566 0,1168826 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,08428566 0,11681527 ! tube morphogenesis GO:0035239 176 86 1,000 0,08772966 0,12151845 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,08807382 0,12192498 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,08807382 0,12185487 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,08807382 0,12178484 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,08807382 0,12171489 ! bone remodeling GO:0046849 27 16 0,000 0,08807382 0,12164502 ! filopodium assembly GO:0046847 32 16 0,000 0,08807382 0,12157523 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,08807382 0,12150552 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,08807382 0,12143589 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,08807382 0,12136634 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,08807382 0,12129686 ! startle response GO:0001964 28 16 0,000 0,08807382 0,12122747 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,08807382 0,12115816 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,08807382 0,12108893 ! protein polyubiquitination GO:0000209 34 16 0,000 0,08807382 0,12101977 ! glutamate metabolic process GO:0006536 22 16 0,000 0,08807382 0,1209507 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,08807382 0,1208817 ! response to osmotic stress GO:0006970 25 16 0,000 0,08807382 0,12081278 ! lysosomal transport GO:0007041 26 16 0,000 0,08807382 0,12074394 ! fructose metabolic process GO:0006000 25 16 0,000 0,08807382 0,12067518 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08807382 0,1206065 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08807382 0,1205379 ! intermediate filament-based process GO:0045103 32 16 0,000 0,08807382 0,12046937 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,08807382 0,12040092 ! negative regulation of immune response GO:0050777 35 16 0,000 0,08807382 0,12033255 ! axon cargo transport GO:0008088 43 16 0,000 0,08807382 0,12026426 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,08807382 0,12019604 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,08807382 0,1201279 ! DNA replication initiation GO:0006270 27 16 0,000 0,08807382 0,12005984 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,08807382 0,11999186 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,08807382 0,11992395 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,08807382 0,11985612 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,08807382 0,11978837 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,08807382 0,11972069 GO:0046466|membrane lipid catabolic process, ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,08807382 0,11965309 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08807382 0,11958557 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,08807382 0,11951812 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,08807382 0,11945075 ! defense response to virus GO:0051607 37 16 0,000 0,08807382 0,11938345 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,0894673 0,12120401 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of DNA binding GO:0051101 155 88 1,000 0,09121513 0,12350231 ! regulation of neurological system process GO:0031644 148 88 1,000 0,09121513 0,12343285 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,09331495 0,12620336 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,09331495 0,12613246 ! metencephalon development GO:0022037 30 17 0,000 0,09331495 0,12606164 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,09331495 0,1259909 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,09331495 0,12592024 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,09331495 0,12584965 ! signal complex assembly GO:0007172 41 17 0,000 0,09331495 0,12577915 ! endothelial cell migration GO:0043542 28 17 0,000 0,09331495 0,12570872 ! inositol metabolic process GO:0006020 28 17 0,000 0,09331495 0,12563838 ! gene silencing by RNA GO:0031047 36 17 0,000 0,09331495 0,12556811 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,09331495 0,12549792 ! limbic system development GO:0021761 36 17 0,000 0,09331495 0,12542781 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,09331495 0,12535778 ! adult walking behavior GO:0007628 33 17 0,000 0,09331495 0,12528782 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,09331495 0,12521795 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,09331495 0,12514815 ! myoblast differentiation GO:0045445 45 17 0,000 0,09331495 0,12507843 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,09331495 0,12500879 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,09331495 0,12493922 ! glycine metabolic process GO:0006544 28 17 0,000 0,09331495 0,12486973 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,09331495 0,12480032 ! NAD metabolic process GO:0019674 29 17 0,000 0,09331495 0,12473099 ! membrane budding GO:0006900 37 17 0,000 0,09331495 0,12466173 ! DNA integration GO:0015074 29 17 0,000 0,09331495 0,12459255 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,09331495 0,12452345 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,09331495 0,12445442 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,09331495 0,12438547 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,09331495 0,1243166 ! genitalia development GO:0048806 30 17 0,000 0,09331495 0,1242478 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,09331495 0,12417908 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,09331495 0,12411044 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,09331495 0,12404187 ! steroid catabolic process GO:0006706 31 17 0,000 0,09331495 0,12397337 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,09331495 0,12390496 ! gas transport GO:0015669 25 17 0,000 0,09331495 0,12383661 ! organic cation transport GO:0015695 31 17 0,000 0,09331495 0,12376835 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,09331495 0,12370015 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,09331495 0,12363204 ! microspike assembly GO:0030035 36 17 0,000 0,09331495 0,123564 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,09331495 0,12349603 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,0947407 0,12531398 ! sterol metabolic process GO:0016125 152 91 1,000 0,09651809 0,1275948 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,09852613 0,13017786 ! neuron maturation GO:0042551 42 18 0,000 0,09852613 0,13010641 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,09852613 0,13003504 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,09852613 0,12996375 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,09852613 0,12989254 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,09852613 0,1298214 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09852613 0,12975034 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,09852613 0,12967936 ! patterning of blood vessels GO:0001569 39 18 0,000 0,09852613 0,12960846 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,09852613 0,12953764 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,09852613 0,12946689 ! epidermis morphogenesis GO:0048730 40 18 0,000 0,09852613 0,12939622 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09852613 0,12932563 ! response to fungus GO:0009620 21 18 0,000 0,09852613 0,12925511 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,09852613 0,12918467 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,09852613 0,12911431 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,09852613 0,12904403 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,09852613 0,12897382 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,09852613 0,12890369 ! vitamin transport GO:0051180 27 18 0,000 0,09852613 0,12883363 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,09852613 0,12876365 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,09852613 0,12869374 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,09852613 0,12862392 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,09852613 0,12855416 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,09852613 0,12848449 ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,10010125 0,13046783 ! carbohydrate biosynthetic process GO:0016051 141 93 1,000 0,10010125 0,13039719 ! negative regulation of multicellular organismal process GO:0051241 166 93 1,000 0,10010125 0,13032663 ! negative regulation of defense response GO:0031348 25 19 0,000 0,10370753 0,1349488 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,10370753 0,13487585 ! skin development GO:0043588 36 19 0,000 0,10370753 0,13480299 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,10370753 0,1347302 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,10370753 0,13465749 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,10370753 0,13458486 ! bile acid metabolic process GO:0008206 29 19 0,000 0,10370753 0,13451231 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,10370753 0,13443983 ! pigmentation during development GO:0048066 41 19 0,000 0,10370753 0,13436744 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,10370753 0,13429512 GO:0030968|endoplasmic reticulum unfolded protein response, ! heme metabolic process GO:0042168 36 19 0,000 0,10370753 0,13422288 ! actin filament bundle formation GO:0051017 42 19 0,000 0,10370753 0,13415071 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,10370753 0,13407863 ! protein export from nucleus GO:0006611 36 19 0,000 0,10370753 0,13400662 ! heart process GO:0003015 30 19 0,000 0,10370753 0,13393469 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,10370753 0,13386284 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,10370753 0,13379106 ! cellular pigmentation GO:0033059 36 19 0,000 0,10370753 0,13371936 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,10370753 0,13364774 ! cell-cell junction organization GO:0045216 35 19 0,000 0,10370753 0,13357619 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,10370753 0,13350472 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,10370753 0,13343333 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,10370753 0,13336201 ! cilium assembly GO:0042384 37 19 0,000 0,10370753 0,13329077 ! peptide hormone secretion GO:0030072 31 19 0,000 0,10370753 0,13321961 ! detection of stimulus GO:0051606 151 96 1,000 0,10554446 0,13550692 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,10885933 0,13968829 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,10885933 0,13961383 ! positive regulation of ossification GO:0045778 47 20 0,000 0,10885933 0,13953944 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,10885933 0,13946514 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,10885933 0,13939092 ! cAMP metabolic process GO:0046058 36 20 0,000 0,10885933 0,13931677 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,10885933 0,13924271 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,10885933 0,13916872 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,10885933 0,13909481 ! retinoid metabolic process GO:0001523 32 20 0,000 0,10885933 0,13902099 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,10885933 0,13894723 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,10885933 0,13887356 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,10885933 0,13879997 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,10885933 0,13872645 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 0,000 0,10885933 0,13865301 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,10885933 0,13857965 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,10885933 0,13850636 ! body fluid secretion GO:0007589 31 20 0,000 0,10885933 0,13843316 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,10885933 0,13836003 ! peptide secretion GO:0002790 35 20 0,000 0,10885933 0,13828698 ! stem cell differentiation GO:0048863 53 20 0,000 0,10885933 0,138214 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,10885933 0,13814111 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,10885933 0,13806828 ! sensory perception of pain GO:0019233 30 20 0,000 0,10885933 0,13799554 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,10885933 0,13792287 ! diencephalon development GO:0021536 34 20 0,000 0,10885933 0,13785028 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,10885933 0,13777777 GO:0006626|protein targeting to mitochondrion, ! detection of chemical stimulus GO:0009593 37 20 0,000 0,10885933 0,13770533 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,10885933 0,13763297 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,10885933 0,13756068 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,10885933 0,13748847 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,10885933 0,13741634 ! actin filament-based movement GO:0030048 43 20 0,000 0,10885933 0,13734428 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,10885933 0,13727229 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,10885933 0,13720039 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,10885933 0,13712855 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,10885933 0,1370568 ! carboxylic acid catabolic process GO:0046395 156 98 1,000 0,10921702 0,13743523 GO:0016054|organic acid catabolic process, ! Golgi vesicle transport GO:0048193 207 99 1,000 0,11106595 0,13968881 ! regulation of cell killing GO:0031341 42 21 0,000 0,11398167 0,14328104 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,11398167 0,14320622 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,11398167 0,14313148 ! hormone secretion GO:0046879 38 21 0,000 0,11398167 0,14305681 ! glycerol metabolic process GO:0006071 34 21 0,000 0,11398167 0,14298223 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,11398167 0,14290772 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,11398167 0,14283329 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,11398167 0,14275893 ! axis specification GO:0009798 38 21 0,000 0,11398167 0,14268466 ! ovarian follicle development GO:0001541 35 21 0,000 0,11398167 0,14261046 ! smooth muscle contraction GO:0006939 46 21 0,000 0,11398167 0,14253633 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,11398167 0,14246229 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,11398167 0,14238832 ! cell aging GO:0007569 44 21 0,000 0,11398167 0,14231443 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,11398167 0,14224062 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,11398167 0,14216688 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,11398167 0,14209322 ! cytolysis GO:0019835 24 21 0,000 0,11398167 0,14201963 ! vasodilation GO:0042311 39 21 0,000 0,11398167 0,14194612 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,11398167 0,14187269 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,11398167 0,14179933 ! oogenesis GO:0048477 36 21 0,000 0,11398167 0,14172605 ! DNA modification GO:0006304 34 21 0,000 0,11398167 0,14165284 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,11398167 0,14157971 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,11398167 0,14150666 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,11398167 0,14143368 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,11398167 0,14136078 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,11398167 0,14128795 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,11398167 0,14121519 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,11398167 0,14114252 ! collagen catabolic process GO:0030574 28 21 0,000 0,11398167 0,14106991 ! sperm-egg recognition GO:0035036 21 21 0,000 0,11398167 0,14099738 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,11907475 0,14722191 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,11907475 0,1471463 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,11907475 0,14707076 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,11907475 0,1469953 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,11907475 0,14691992 ! regeneration GO:0031099 41 22 0,000 0,11907475 0,14684462 ! keratinization GO:0031424 28 22 0,000 0,11907475 0,14676939 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,11907475 0,14669424 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,11907475 0,14661916 ! sensory perception of taste GO:0050909 28 22 0,000 0,11907475 0,14654417 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 0,000 0,11907475 0,14646925 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,11907475 0,1463944 ! vacuolar transport GO:0007034 36 22 0,000 0,11907475 0,14631963 ! lysosome organization GO:0007040 41 22 0,000 0,11907475 0,14624494 ! central nervous system neuron development GO:0021954 46 22 0,000 0,11907475 0,14617033 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,11907475 0,14609579 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,11907475 0,14602133 ! fucose metabolic process GO:0006004 39 22 0,000 0,11907475 0,14594694 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,11907475 0,14587263 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,11907475 0,14579839 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,11907475 0,14572423 ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,11907475 0,14565015 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,11907475 0,14557614 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,11907475 0,14550221 ! sarcomere organization GO:0045214 30 22 0,000 0,11907475 0,14542835 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,11907475 0,14535456 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,11907475 0,14528085 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,11907475 0,14520722 ! protein stabilization GO:0050821 39 22 0,000 0,11907475 0,14513366 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,12413871 0,15122924 ! gluconeogenesis GO:0006094 33 23 0,000 0,12413871 0,15115271 ! viral genome replication GO:0019079 41 23 0,000 0,12413871 0,15107625 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,12413871 0,15099987 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,12413871 0,15092357 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,12413871 0,15084735 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,12413871 0,1507712 GO:0006044|N-acetylglucosamine metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,12413871 0,15069513 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,12413871 0,15061914 ! response to ethanol GO:0045471 46 23 0,000 0,12413871 0,15054322 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,12413871 0,15046738 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,12413871 0,15039162 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,12413871 0,15031593 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,12413871 0,15024032 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,12413871 0,15016478 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,12413871 0,15008932 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,12413871 0,15001394 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,12413871 0,14993863 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,12413871 0,1498634 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,12413871 0,14978824 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,12413871 0,14971316 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,12413871 0,14963815 ! fatty acid transport GO:0015908 44 23 0,000 0,12413871 0,14956322 ! platelet activation GO:0030168 37 23 0,000 0,12413871 0,14948836 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,12413871 0,14941358 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,12413871 0,14933887 ! hormone transport GO:0009914 40 23 0,000 0,12413871 0,14926424 ! cell-cell recognition GO:0009988 25 23 0,000 0,12413871 0,14918968 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,12413871 0,1491152 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,12413871 0,14904079 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,12413871 0,14896646 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,12413871 0,1488922 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,12413871 0,14881801 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,12917374 0,1547769 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,12917374 0,15469986 ! vesicle docking GO:0048278 47 24 0,000 0,12917374 0,15462289 ! vacuole organization GO:0007033 43 24 0,000 0,12917374 0,154546 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,12917374 0,15446919 ! digestive system process GO:0022600 39 24 0,000 0,12917374 0,15439246 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,12917374 0,1543158 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,12917374 0,15423921 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,12917374 0,15416271 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,12917374 0,15408627 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,12917374 0,15400992 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,12917374 0,15393364 ! membrane depolarization GO:0051899 39 24 0,000 0,12917374 0,15385743 ! pentose metabolic process GO:0019321 35 24 0,000 0,12917374 0,1537813 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,12917374 0,15370525 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,12917374 0,15362927 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,12917374 0,15355337 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,12917374 0,15347754 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,12917374 0,15340178 ! regulation of amine transport GO:0051952 40 24 0,000 0,12917374 0,15332611 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,13417998 0,15918986 ! phototransduction GO:0007602 33 25 0,000 0,13417998 0,15911141 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,13417998 0,15903303 GO:0006479|protein amino acid methylation, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 0,000 0,13417998 0,15895472 ! sperm motility GO:0030317 31 25 0,000 0,13417998 0,1588765 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,13417998 0,15879835 ! negative regulation of DNA replication GO:0008156 42 25 0,000 0,13417998 0,15872028 ! receptor metabolic process GO:0043112 46 25 0,000 0,13417998 0,15864228 ! response to starvation GO:0042594 42 25 0,000 0,13417998 0,15856436 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,13417998 0,15848652 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,13417998 0,15840875 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,13417998 0,15833107 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,13417998 0,15825345 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 0,000 0,13417998 0,15817591 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,13417998 0,15809845 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,13417998 0,15802107 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,13417998 0,15794376 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,13417998 0,15786652 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,13417998 0,15778937 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,13417998 0,15771228 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,13417998 0,15763527 ! telomere organization GO:0032200 43 25 0,000 0,13417998 0,15755834 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,13417998 0,15748148 GO:0060606|tube closure, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,13915761 0,16324389 ! embryonic pattern specification GO:0009880 44 26 0,000 0,13915761 0,16316434 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,13915761 0,16308486 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,13915761 0,16300546 ! initiation of viral infection GO:0019059 57 26 0,000 0,13915761 0,16292614 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,13915761 0,1628469 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,13915761 0,16276773 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,13915761 0,16268864 ! tube lumen formation GO:0035148 50 26 0,000 0,13915761 0,16260963 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,13915761 0,16253069 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,13915761 0,16245183 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,13915761 0,16237305 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,13915761 0,16229434 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,13915761 0,16221571 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,13915761 0,16213715 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,13915761 0,16205867 ! blastocyst development GO:0001824 49 26 0,000 0,13915761 0,16198027 ! leukocyte proliferation GO:0070661 52 26 0,000 0,13915761 0,16190194 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,13915761 0,16182369 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,13915761 0,16174552 ! iron ion transport GO:0006826 59 27 0,000 0,14410679 0,16741716 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,14410679 0,16733636 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,14410679 0,16725564 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,14410679 0,167175 ! fat cell differentiation GO:0045444 50 27 0,000 0,14410679 0,16709443 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,14410679 0,16701394 ! mitochondrial membrane organization GO:0007006 57 27 0,000 0,14410679 0,16693353 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,14410679 0,1668532 ! autophagy GO:0006914 41 27 0,000 0,14410679 0,16677294 ! response to toxin GO:0009636 47 27 0,000 0,14410679 0,16669276 ! primary neural tube formation GO:0014020 51 27 0,000 0,14410679 0,16661266 ! base-excision repair GO:0006284 41 27 0,000 0,14410679 0,16653263 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,14410679 0,16645269 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,14410679 0,16637281 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,14410679 0,16629302 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,14410679 0,1662133 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,14410679 0,16613366 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,14902768 0,17172443 ! circadian rhythm GO:0007623 50 28 0,000 0,14902768 0,17164222 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,14902768 0,1715601 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,14902768 0,17147805 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,14902768 0,17139608 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,14902768 0,17131419 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,14902768 0,17123238 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,14902768 0,17115065 ! synaptogenesis GO:0007416 42 28 0,000 0,14902768 0,17106899 ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,14902768 0,17098741 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,14902768 0,17090591 ! translational initiation GO:0006413 65 29 0,000 0,15392044 0,17643286 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,15392044 0,17634885 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,15392044 0,17626491 ! regulation of pH GO:0006885 43 29 0,000 0,15392044 0,17618106 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,15392044 0,17609728 ! catechol metabolic process GO:0009712 54 29 0,000 0,15392044 0,17601358 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,15392044 0,17592997 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,15392044 0,17584643 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,15392044 0,17576297 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,15392044 0,17567959 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,15392044 0,17559629 ! response to organic cyclic substance GO:0014070 55 29 0,000 0,15392044 0,17551307 ! cell fate determination GO:0001709 60 29 0,000 0,15392044 0,17542993 ! detection of light stimulus GO:0009583 38 29 0,000 0,15392044 0,17534686 ! negative regulation of neuron apoptosis GO:0043524 56 29 0,000 0,15392044 0,17526388 ! regulation of coagulation GO:0050818 46 29 0,000 0,15392044 0,17518097 ! phenol metabolic process GO:0018958 55 30 0,000 0,15878523 0,18063227 ! zinc ion transport GO:0006829 45 30 0,000 0,15878523 0,18054691 ! membrane docking GO:0022406 61 30 0,000 0,15878523 0,18046163 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,15878523 0,18037642 ! regulation of innate immune response GO:0045088 51 30 0,000 0,15878523 0,1802913 ! myofibril assembly GO:0030239 47 30 0,000 0,15878523 0,18020625 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 47 30 0,000 0,15878523 0,18012129 ! phospholipid transport GO:0015914 51 30 0,000 0,15878523 0,18003641 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,15878523 0,17995161 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,15878523 0,17986688 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,16362221 0,18525884 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,16362221 0,1851717 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,16362221 0,18508464 GO:0009799|determination of symmetry, ! inner ear morphogenesis GO:0042472 47 31 0,000 0,16362221 0,18499766 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,16362221 0,18491077 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,16362221 0,18482396 ! ovulation cycle process GO:0022602 49 31 0,000 0,16362221 0,18473723 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,16362221 0,18465058 ! peptide transport GO:0015833 55 31 0,000 0,16362221 0,18456401 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,16362221 0,18447752 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,16362221 0,18439111 ! natural killer cell activation GO:0030101 45 31 0,000 0,16362221 0,18430479 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,16362221 0,18421854 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,16362221 0,18413238 ! negative regulation of transcription regulator activity GO:0090048 58 31 0,000 0,16362221 0,1840463 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,16362221 0,18396029 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,16843153 0,18927897 ! response to hydrogen peroxide GO:0042542 50 32 0,000 0,16843153 0,1891906 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,16843153 0,18910232 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,16843153 0,18901412 ! cholesterol transport GO:0030301 56 32 0,000 0,16843153 0,188926 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,16843153 0,18883796 ! spliceosome assembly GO:0000245 67 32 0,000 0,16843153 0,18875001 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,16843153 0,18866213 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,16843153 0,18857434 ! response to ionizing radiation GO:0010212 65 32 0,000 0,16843153 0,18848664 ! muscle cell development GO:0055001 49 32 0,000 0,16843153 0,18839901 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,16843153 0,18831146 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,16843153 0,188224 ! ovulation cycle GO:0042698 51 32 0,000 0,16843153 0,18813661 ! BMP signaling pathway GO:0030509 64 32 0,000 0,16843153 0,18804931 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,16843153 0,18796209 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,16843153 0,18787495 ! gene silencing GO:0016458 65 32 0,000 0,16843153 0,18778789 ! DNA damage checkpoint GO:0000077 71 33 0,000 0,17321336 0,1930298 ! post-embryonic development GO:0009791 69 33 0,000 0,17321336 0,19294044 ! protein targeting to membrane GO:0006612 68 33 0,000 0,17321336 0,19285116 ! ceramide metabolic process GO:0006672 64 33 0,000 0,17321336 0,19276196 ! sterol transport GO:0015918 57 33 0,000 0,17321336 0,19267284 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,17321336 0,1925838 ! adult locomotory behavior GO:0008344 59 33 0,000 0,17321336 0,19249485 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,17321336 0,19240598 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,17796785 0,19759606 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,17796785 0,19750491 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,17796785 0,19741386 ! mismatch repair GO:0006298 46 34 0,000 0,17796785 0,19732288 ! spermatid development GO:0007286 63 34 0,000 0,17796785 0,19723199 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,17796785 0,19714118 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,17796785 0,19705046 ! negative regulation of secretion GO:0051048 63 35 0,000 0,18269516 0,20219161 ! negative regulation of DNA metabolic process GO:0051053 61 35 0,000 0,18269516 0,20209864 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,18269516 0,20200577 ! negative regulation of cell adhesion GO:0007162 81 35 0,000 0,18269516 0,20191298 ! female gonad development GO:0008585 58 35 0,000 0,18269516 0,20182027 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,18269516 0,20172765 GO:0006639|acylglycerol metabolic process, ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,18269516 0,20163512 ! neural tube formation GO:0001841 67 35 0,000 0,18269516 0,20154266 ! vesicle localization GO:0051648 64 35 0,000 0,18269516 0,2014503 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,18739544 0,20653844 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,18739544 0,20644387 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,18739544 0,20634939 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,18739544 0,20625499 ! DNA integrity checkpoint GO:0031570 75 36 0,000 0,18739544 0,20616068 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,18739544 0,20606646 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,18739544 0,20597232 ! aerobic respiration GO:0009060 55 36 0,000 0,18739544 0,20587827 ! androgen receptor signaling pathway GO:0030521 74 36 0,000 0,18739544 0,20578431 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,18739544 0,20569043 ! RNA export from nucleus GO:0006405 56 37 0,000 0,19206884 0,21072395 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,19206884 0,2106279 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,19206884 0,21053195 ! actomyosin structure organization GO:0031032 62 37 0,000 0,19206884 0,21043608 ! organic anion transport GO:0015711 68 37 0,000 0,19206884 0,21034029 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,19206884 0,2102446 ! negative regulation of DNA binding GO:0043392 68 37 0,000 0,19206884 0,21014899 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,19206884 0,21005346 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,19206884 0,20995803 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,19206884 0,20986268 GO:0015986|ATP synthesis coupled proton transport, ! regulation of protein stability GO:0031647 73 37 0,000 0,19206884 0,20976742 ! pigment metabolic process GO:0042440 80 37 0,000 0,19206884 0,20967224 ! spermatid differentiation GO:0048515 66 37 0,000 0,19206884 0,20957715 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,19671552 0,2145501 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,19671552 0,21445289 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,19671552 0,21435577 ! development of primary female sexual characteristics GO:0046545 67 38 0,000 0,19671552 0,21425873 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 67 38 0,000 0,19671552 0,21416178 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,19671552 0,21406492 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,19671552 0,21396814 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,19671552 0,21387146 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,19671552 0,21377486 ! mRNA catabolic process GO:0006402 71 39 0,000 0,20133562 0,21869684 ! organic ether metabolic process GO:0018904 55 39 0,000 0,20133562 0,21859815 ! ion transmembrane transport GO:0034220 66 39 0,000 0,20133562 0,21849955 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,20133562 0,21840104 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,20133562 0,21830262 ! RNA modification GO:0009451 57 39 0,000 0,20133562 0,21820428 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,20133562 0,21810604 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,20592931 0,22298196 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,20592931 0,22288166 ! feeding behavior GO:0007631 59 40 0,000 0,20592931 0,22278144 ! negative regulation of binding GO:0051100 72 40 0,000 0,20592931 0,22268131 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,20592931 0,22258128 ! maintenance of protein location GO:0045185 91 40 0,000 0,20592931 0,22248133 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,21049673 0,22731379 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,21049673 0,22721181 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,21049673 0,22710992 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,21049673 0,22700813 ! female gamete generation GO:0007292 61 41 0,000 0,21049673 0,22690642 ! polyol metabolic process GO:0019751 66 41 0,000 0,21049673 0,2268048 ! response to reactive oxygen species GO:0000302 67 42 0,000 0,21503803 0,23159422 ! regulation of tube size GO:0035150 71 42 0,000 0,21503803 0,2314906 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,21503803 0,23138707 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,21503803 0,23128363 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,21503803 0,23118029 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,21503803 0,23107704 ! regulation of protein secretion GO:0050708 71 42 0,000 0,21503803 0,23097388 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,21955335 0,23571859 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,21955335 0,23561345 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,21955335 0,23550841 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,21955335 0,23540346 ! striated muscle contraction GO:0006941 77 43 0,000 0,21955335 0,2352986 ! phagocytosis GO:0006909 90 43 0,000 0,21955335 0,23519384 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,21955335 0,23508917 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,22404285 0,23978964 ! double-strand break repair GO:0006302 81 44 0,000 0,22404285 0,23968302 ! biopolymer methylation GO:0043414 84 44 0,000 0,22404285 0,23957649 ! B cell differentiation GO:0030183 107 44 0,000 0,22404285 0,23947006 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,22404285 0,23936372 ! maintenance of location in cell GO:0051651 97 44 0,000 0,22404285 0,23925748 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,22850668 0,24391618 ! glycolysis GO:0006096 65 45 0,000 0,22850668 0,24380801 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,22850668 0,24369994 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,22850668 0,24359197 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,22850668 0,24348409 ! response to calcium ion GO:0051592 81 47 0,000 0,23735788 0,25280348 ! endosome transport GO:0016197 108 47 0,000 0,23735788 0,25269162 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,23735788 0,25257986 ! JNK cascade GO:0007254 91 47 0,000 0,23735788 0,25246819 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,23735788 0,25235663 ! methylation GO:0032259 90 47 0,000 0,23735788 0,25224516 ! protein homooligomerization GO:0051260 76 47 0,000 0,23735788 0,2521338 ! mitochondrial transport GO:0006839 82 48 0,000 0,24174554 0,25668128 ! Notch signaling pathway GO:0007219 96 48 0,000 0,24174554 0,25656805 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,24174554 0,25645493 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,24174554 0,2563419 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,24610811 0,26085291 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,24610811 0,26073805 ! regulation of ion transport GO:0043269 77 49 0,000 0,24610811 0,26062329 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,24610811 0,26050863 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,24610811 0,26039407 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,24610811 0,26027961 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,24610811 0,26016525 ! neuromuscular process GO:0050905 99 50 0,000 0,25044572 0,26463435 ! inner ear development GO:0048839 79 50 0,000 0,25044572 0,26451818 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,25044572 0,26440211 ! viral infectious cycle GO:0019058 99 51 0,000 0,25475852 0,26883728 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,25475852 0,26871942 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,25475852 0,26860166 ! excretion GO:0007588 83 51 0,000 0,25475852 0,26848401 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,25475852 0,26836646 ! chromatin remodeling GO:0006338 109 51 0,000 0,25475852 0,26824901 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,25475852 0,26813167 ! vesicle organization GO:0016050 107 51 0,000 0,25475852 0,26801443 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,26331024 0,27689005 ! RNA catabolic process GO:0006401 93 53 0,000 0,26331024 0,27676908 ! regulation of translational initiation GO:0006446 82 53 0,000 0,26331024 0,27664822 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,26331024 0,27652747 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,26331024 0,27640682 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,26331024 0,27628628 ! cell maturation GO:0048469 100 53 0,000 0,26331024 0,27616584 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,26331024 0,2760455 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,26754944 0,28036757 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,26754944 0,28024551 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,26754944 0,28012356 ! chloride transport GO:0006821 90 55 0,000 0,27176438 0,28441284 ! glucose catabolic process GO:0006007 82 55 0,000 0,27176438 0,28428918 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,27176438 0,28416563 ! aging GO:0007568 103 55 0,000 0,27176438 0,28404218 ! RNA elongation GO:0006354 79 55 0,000 0,27176438 0,28391885 ! nuclear export GO:0051168 97 55 0,000 0,27176438 0,28379562 ! regulation of actin filament length GO:0030832 105 56 0,000 0,27595522 0,28804696 ! sensory perception of smell GO:0007608 80 56 0,000 0,27595522 0,28792205 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,27595522 0,28779725 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,27595522 0,28767255 ! proton transport GO:0015992 94 56 0,000 0,27595522 0,28754796 ! maintenance of location GO:0051235 118 57 0,000 0,28012207 0,2917635 ! hydrogen transport GO:0006818 97 58 0,000 0,28426508 0,29595057 ! regulation of endocytosis GO:0030100 91 58 0,000 0,28426508 0,29582257 ! adult behavior GO:0030534 99 58 0,000 0,28426508 0,29569467 ! positive regulation of secretion GO:0051047 95 59 0,000 0,28838438 0,29984997 ! regulation of cellular component size GO:0032535 109 59 0,000 0,28838438 0,29972044 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,28838438 0,29959103 GO:0032313|regulation of Rab GTPase activity, ! DNA damage response, signal transduction GO:0042770 128 60 0,000 0,29248011 0,30371478 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,29248011 0,30358376 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,29655241 0,30767792 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,29655241 0,3075453 ! tRNA processing GO:0008033 89 61 0,000 0,29655241 0,30741279 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,29655241 0,3072804 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,3006014 0,31134178 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,30462721 0,31537568 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,30462721 0,31524003 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,30462721 0,3151045 ! steroid hormone receptor signaling pathway GO:0030518 129 63 0,000 0,30462721 0,31496909 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,30862999 0,31897069 ! cell redox homeostasis GO:0045454 102 64 0,000 0,30862999 0,31883373 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,30862999 0,31869689 ! multicellular organism reproduction GO:0032504 111 64 0,000 0,30862999 0,31856017 GO:0048609|reproductive process in a multicellular organism, ! single fertilization GO:0007338 75 64 0,000 0,30862999 0,31842357 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,31260986 0,32239148 ! myeloid cell differentiation GO:0030099 111 65 0,000 0,31260986 0,32225335 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,31656695 0,32619276 ! actin filament organization GO:0007015 148 66 0,000 0,31656695 0,32605312 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,31656695 0,3259136 ! secondary metabolic process GO:0019748 116 66 0,000 0,31656695 0,3257742 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,32050139 0,32968207 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,32050139 0,32954118 ! hexose catabolic process GO:0019320 104 67 0,000 0,32050139 0,32940041 ! activation of immune response GO:0002253 105 67 0,000 0,32050139 0,32925976 ! amino acid transport GO:0006865 125 68 0,000 0,32441332 0,33313634 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,32441332 0,33299422 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 0,000 0,32441332 0,33285221 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,32441332 0,33271033 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,32830285 0,33655588 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,32830285 0,33641254 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,32830285 0,33626933 ! antigen processing and presentation GO:0019882 104 69 0,000 0,32830285 0,33612623 ! amine catabolic process GO:0009310 117 71 0,000 0,33601524 0,34387608 ! B cell activation GO:0042113 160 71 0,000 0,33601524 0,34372988 ! regulation of blood pressure GO:0008217 125 73 0,000 0,34363959 0,35137988 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,34363959 0,35123061 ! fertilization GO:0009566 90 73 0,000 0,34363959 0,35108146 ! transition metal ion transport GO:0000041 126 74 0,000 0,34741906 0,35479213 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,34741906 0,3546416 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,34741906 0,3544912 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,35117689 0,35817363 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,35117689 0,35802186 ! rhythmic process GO:0048511 128 75 0,000 0,35117689 0,35787022 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,3549132 0,36152463 ! defense response to bacterium GO:0042742 89 76 0,000 0,3549132 0,36137163 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,3549132 0,36121877 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,35862813 0,36484536 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,35862813 0,36469116 ! blood coagulation GO:0007596 146 78 0,000 0,36232178 0,36829159 GO:0050817|coagulation, ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,36232178 0,36813606 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,36599428 0,37171053 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,36599428 0,37155369 ! response to metal ion GO:0010038 140 80 0,000 0,36964576 0,37510236 ! muscle cell differentiation GO:0042692 159 80 0,000 0,36964576 0,37494422 ! inorganic anion transport GO:0015698 138 80 0,000 0,36964576 0,37478622 ! digestion GO:0007586 112 81 0,000 0,37327632 0,37830785 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,37327632 0,37814856 ! hemostasis GO:0007599 158 84 0,000 0,38404375 0,38889279 ! response to unfolded protein GO:0006986 131 85 0,000 0,38759186 0,39232058 ! nucleosome assembly GO:0006334 122 85 0,000 0,38759186 0,3921556 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,38759186 0,39199076 ! amine biosynthetic process GO:0009309 138 86 0,000 0,39111965 0,39539239 ! response to inorganic substance GO:0010035 153 86 0,000 0,39111965 0,39522633 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,39111965 0,3950604 ! chromatin assembly GO:0031497 124 86 0,000 0,39111965 0,39489462 ! alcohol catabolic process GO:0046164 130 86 0,000 0,39111965 0,39472898 ! amine transport GO:0015837 155 86 0,000 0,39111965 0,39456347 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,39462724 0,39793509 ! cellular respiration GO:0045333 135 88 0,000 0,39811473 0,40128364 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,39811473 0,4011156 ! cellular defense response GO:0006968 114 89 0,000 0,40158225 0,40443989 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,40502991 0,40774141 ! response to protein stimulus GO:0051789 149 91 0,000 0,40845782 0,41102029 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,40845782 0,41084846 ! nucleosome organization GO:0034728 138 92 0,000 0,41186609 0,41410356 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,41186609 0,41393058 ! vitamin metabolic process GO:0006766 139 92 0,000 0,41186609 0,41375775 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,41862417 0,42037135 ! female pregnancy GO:0007565 164 94 0,000 0,41862417 0,42019598 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,42197421 0,42338196 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,42530505 0,42654604 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,42530505 0,42636831 ! positive regulation of immune response GO:0050778 156 96 0,000 0,42530505 0,42619073 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,4286168 0,42933057 ! hormone metabolic process GO:0042445 157 97 0,000 0,4286168 0,4291519 ! response to virus GO:0009615 160 98 0,000 0,43190958 0,43226891 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,43190958 0,43208917 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,4351835 0,4351835