pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6906-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of cell migration GO:0030335 92 51 9,000 4,401E-11 1,012E-07 ! positive regulation of cell motion GO:0051272 99 56 9,000 1,177E-10 1,354E-07 ! negative regulation of phosphorylation GO:0042326 41 23 6,000 1,379E-09 1,057E-06 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 6,000 2,661E-09 1,53E-06 GO:0045936|negative regulation of phosphate metabolic process, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 4,000 1,816E-08 8,355E-06 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 3,000 3,987E-08 1,528E-05 ! induction of positive chemotaxis GO:0050930 14 8 3,000 5,458E-07 1,793E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 5,805E-07 1,669E-04 ! positive regulation of locomotion GO:0040017 35 20 4,000 1,034E-06 2,643E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 4,000 1,347E-06 3,098E-04 ! protein sumoylation GO:0016925 12 10 3,000 1,613E-06 3,373E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 4,000 1,73E-06 3,315E-04 ! regulation of behavior GO:0050795 38 22 4,000 1,73E-06 3,06E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 2,037E-06 3,347E-04 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 2,516E-06 3,858E-04 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of endothelial cell proliferation GO:0001938 18 11 3,000 2,516E-06 3,617E-04 ! focal adhesion formation GO:0048041 24 11 3,000 2,516E-06 3,404E-04 ! regulation of mRNA stability GO:0043488 27 12 3,000 3,746E-06 4,786E-04 ! regulation of RNA stability GO:0043487 28 13 3,000 5,37E-06 6,501E-04 ! response to hypoxia GO:0001666 132 72 6,000 5,595E-06 6,435E-04 ! response to oxygen levels GO:0070482 137 74 6,000 6,727E-06 7,368E-04 ! negative regulation of growth GO:0045926 123 75 6,000 7,36E-06 7,695E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 7,463E-06 7,463E-04 ! negative regulation of survival gene product expression GO:0008634 6 5 2,000 8,443E-06 8,091E-04 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 2,000 8,443E-06 7,767E-04 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 3,000 1,01E-05 8,935E-04 ! regulation of protein stability GO:0031647 48 32 4,000 1,224E-05 1,043E-03 ! nucleus organization GO:0006997 49 33 4,000 1,432E-05 1,176E-03 ! prostate gland development GO:0030850 9 6 2,000 1,677E-05 1,33E-03 ! ER overload response GO:0006983 7 6 2,000 1,677E-05 1,285E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 1,677E-05 1,244E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 3,000 1,735E-05 1,247E-03 ! cell-substrate junction assembly GO:0007044 39 17 3,000 1,735E-05 1,209E-03 ! cell cycle arrest GO:0007050 150 86 6,000 1,825E-05 1,234E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 6,000 1,825E-05 1,199E-03 ! interphase GO:0051325 159 88 6,000 2,122E-05 1,356E-03 ! regulation of homeostatic process GO:0032844 105 60 5,000 2,269E-05 1,411E-03 ! cell-matrix adhesion GO:0007160 114 61 5,000 2,497E-05 1,511E-03 ! negative regulation of cell growth GO:0030308 106 62 5,000 2,743E-05 1,618E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 3,000 2,784E-05 1,601E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 3,000 2,784E-05 1,562E-03 ! apoptotic nuclear changes GO:0030262 24 19 3,000 2,784E-05 1,524E-03 ! positive regulation of intracellular transport GO:0032388 29 19 3,000 2,784E-05 1,489E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 2,914E-05 1,523E-03 ! B cell lineage commitment GO:0002326 17 7 2,000 2,914E-05 1,489E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 2,914E-05 1,457E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 2,914E-05 1,426E-03 ! pigmentation GO:0043473 74 38 4,000 2,914E-05 1,396E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 5,000 3,008E-05 1,412E-03 ! peptidyl-amino acid modification GO:0018193 147 93 6,000 3,042E-05 1,4E-03 ! negative regulation of cell size GO:0045792 108 64 5,000 3,293E-05 1,485E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 3,761E-05 1,664E-03 ! cell-substrate adhesion GO:0031589 121 66 5,000 3,928E-05 1,705E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 3,000 4,235E-05 1,804E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 3,000 4,235E-05 1,771E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 3,000 4,235E-05 1,739E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 4,629E-05 1,868E-03 ! middle ear morphogenesis GO:0042474 9 8 2,000 4,629E-05 1,836E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 4,629E-05 1,804E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 2,000 4,629E-05 1,774E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 4,629E-05 1,745E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 4,629E-05 1,717E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 4,629E-05 1,69E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 5,377E-05 1,932E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 6,173E-05 2,184E-03 ! regulation of glycolysis GO:0006110 15 9 2,000 6,895E-05 2,403E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 6,895E-05 2,367E-03 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 2,000 6,895E-05 2,332E-03 ! mitochondrion organization GO:0007005 104 73 5,000 6,966E-05 2,322E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 3,000 7,352E-05 2,416E-03 ! mitochondrial membrane organization GO:0007006 39 24 3,000 7,352E-05 2,382E-03 ! response to toxin GO:0009636 38 24 3,000 7,352E-05 2,349E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 8,688E-05 2,737E-03 ! regulation of DNA replication GO:0006275 75 48 4,000 9,203E-05 2,861E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 9,78E-05 2,999E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 2,000 9,78E-05 2,96E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 9,78E-05 2,921E-03 GO:0043470|regulation of carbohydrate catabolic process, ! cartilage development GO:0051216 70 49 4,000 1,017E-04 2,999E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 1,234E-04 3,592E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 1,335E-04 3,839E-03 ! actin cytoskeleton reorganization GO:0031532 21 11 2,000 1,335E-04 3,792E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 1,335E-04 3,745E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,335E-04 3,7E-03 GO:0042130|negative regulation of T cell proliferation, ! cell junction assembly GO:0034329 56 28 3,000 1,375E-04 3,765E-03 ! skeletal system morphogenesis GO:0048705 78 53 4,000 1,484E-04 4,016E-03 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 1,629E-04 4,356E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,768E-04 4,674E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 2,000 1,768E-04 4,621E-03 ! negative regulation of cell activation GO:0050866 44 30 3,000 1,813E-04 4,686E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 2,1E-04 5,367E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 2,281E-04 5,764E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 2,282E-04 5,706E-03 ! positive regulation of protein import into nucleus GO:0042307 23 13 2,000 2,282E-04 5,644E-03 ! cellular pigmentation GO:0033059 24 13 2,000 2,282E-04 5,584E-03 ! lung development GO:0030324 94 59 4,000 2,473E-04 5,987E-03 ! actin filament organization GO:0007015 95 59 4,000 2,473E-04 5,924E-03 ! cell junction organization GO:0034330 63 33 3,000 2,648E-04 6,279E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 2,884E-04 6,769E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 2,884E-04 6,701E-03 GO:0060675|ureteric bud morphogenesis, ! G1/S transition checkpoint GO:0031575 33 14 2,000 2,884E-04 6,634E-03 ! axon cargo transport GO:0008088 27 14 2,000 2,884E-04 6,568E-03 ! negative regulation of blood coagulation GO:0030195 19 14 2,000 2,884E-04 6,504E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 2,884E-04 6,441E-03 ! urogenital system development GO:0001655 101 61 4,000 2,894E-04 6,399E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 2,894E-04 6,338E-03 ! mitotic cell cycle checkpoint GO:0007093 63 34 3,000 2,979E-04 6,463E-03 ! respiratory tube development GO:0030323 99 62 4,000 3,123E-04 6,714E-03 ! regulation of response to external stimulus GO:0032101 139 96 5,000 3,167E-04 6,744E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 3,338E-04 7,044E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 3,58E-04 7,486E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 3,58E-04 7,418E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 3,58E-04 7,352E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 3,58E-04 7,287E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 3,58E-04 7,223E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 2,000 3,58E-04 7,16E-03 ! cell cycle checkpoint GO:0000075 108 64 4,000 3,624E-04 7,186E-03 ! respiratory system development GO:0060541 100 64 4,000 3,624E-04 7,124E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 4,376E-04 8,529E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 4,376E-04 8,457E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 4,376E-04 8,386E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 5,276E-04 0,01002869 ! actin filament bundle formation GO:0051017 26 17 2,000 5,276E-04 9,946E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 5,276E-04 9,866E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 5,276E-04 9,786E-03 ! negative regulation of coagulation GO:0050819 23 17 2,000 5,276E-04 9,708E-03 ! positive regulation of protein transport GO:0051222 55 40 3,000 5,615E-04 0,0102487 ! positive regulation of DNA replication GO:0045740 29 18 2,000 6,287E-04 0,01138568 ! cellular response to nutrient levels GO:0031669 27 18 2,000 6,287E-04 0,01129673 ! regulation of glucose import GO:0046324 21 18 2,000 6,287E-04 0,01120916 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 6,287E-04 0,01112293 ! tube morphogenesis GO:0035239 118 73 4,000 6,664E-04 0,01169957 ! mitochondrial transport GO:0006839 60 42 3,000 6,775E-04 0,01180522 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 6,775E-04 0,01171646 ! cellular component disassembly GO:0022411 64 42 3,000 6,775E-04 0,01162903 ! branching morphogenesis of a tube GO:0048754 72 42 3,000 6,775E-04 0,01154288 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 7,413E-04 0,01253748 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 32 19 2,000 7,413E-04 0,01244597 ! regulation of endothelial cell migration GO:0010594 40 19 2,000 7,413E-04 0,01235578 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 7,413E-04 0,01226689 ! activation of caspase activity GO:0006919 65 43 3,000 7,415E-04 0,01218164 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 7,415E-04 0,01209525 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 8,096E-04 0,01311358 ! gland development GO:0048732 148 77 4,000 8,501E-04 0,0136732 ! microtubule-based transport GO:0010970 37 20 2,000 8,661E-04 0,01383319 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 8,661E-04 0,01373779 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 8,821E-04 0,01389534 ! negative regulation of bone resorption GO:0045779 10 5 1,000 8,901E-04 0,01392705 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 8,901E-04 0,01383294 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 8,901E-04 0,01374011 ! embryonic hemopoiesis GO:0035162 10 5 1,000 8,901E-04 0,01364851 ! positive regulation of glycolysis GO:0045821 11 5 1,000 8,901E-04 0,01355812 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 8,901E-04 0,01346892 ! epithelial cell proliferation GO:0050673 6 5 1,000 8,901E-04 0,01338089 ! microvillus organization GO:0032528 7 5 1,000 8,901E-04 0,013294 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 1,000 8,901E-04 0,01320823 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 8,901E-04 0,01312356 ! early endosome to late endosome transport GO:0045022 11 5 1,000 8,901E-04 0,01303997 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 8,901E-04 0,01295744 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 8,901E-04 0,01287595 ! positive regulation of chemokine production GO:0032722 7 5 1,000 8,901E-04 0,01279547 ! apical protein localization GO:0045176 6 5 1,000 8,901E-04 0,012716 ! triglyceride catabolic process GO:0019433 6 5 1,000 8,901E-04 0,01263751 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 8,901E-04 0,01255997 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 8,901E-04 0,01248339 ! response to UV GO:0009411 75 46 3,000 9,589E-04 0,01336692 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,003E-03 0,01390206 ! cell aging GO:0007569 32 21 2,000 1,003E-03 0,01381882 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 1,003E-03 0,01373656 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 1,04E-03 0,01415936 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of caspase activity GO:0043280 72 48 3,000 1,127E-03 0,01524252 GO:0010952|positive regulation of peptidase activity, ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 1,154E-03 0,01551734 GO:0010810|regulation of cell-substrate adhesion, ! ureteric bud development GO:0001657 32 22 2,000 1,154E-03 0,01542713 ! regulation of blood coagulation GO:0030193 34 22 2,000 1,154E-03 0,01533795 ! regulation of angiogenesis GO:0045765 94 49 3,000 1,218E-03 0,01609636 ! regulation of intracellular transport GO:0032386 78 49 3,000 1,218E-03 0,01600438 ! morphogenesis of a branching structure GO:0001763 86 49 3,000 1,218E-03 0,01591344 ! ear development GO:0043583 72 50 3,000 1,314E-03 0,01707278 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,317E-03 0,01702354 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 1,317E-03 0,01692843 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,317E-03 0,01683439 ! cellular response to oxidative stress GO:0034599 33 23 2,000 1,317E-03 0,01674138 ! regulation of helicase activity GO:0051095 11 6 1,000 1,327E-03 0,01676721 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,327E-03 0,01667559 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,327E-03 0,01658496 ! mRNA stabilization GO:0048255 15 6 1,000 1,327E-03 0,01649531 GO:0043489|RNA stabilization, ! pigment granule organization GO:0048753 11 6 1,000 1,327E-03 0,01640662 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,327E-03 0,01631889 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 1,327E-03 0,01623209 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,327E-03 0,0161462 ! glycerol ether catabolic process GO:0044269 8 6 1,000 1,327E-03 0,01606122 GO:0046464|acylglycerol catabolic process, ! neuron apoptosis GO:0051402 8 6 1,000 1,327E-03 0,01597713 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 1,327E-03 0,01589392 ! purine base biosynthetic process GO:0009113 14 6 1,000 1,327E-03 0,01581157 ! gas homeostasis GO:0033483 11 6 1,000 1,327E-03 0,01573006 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,327E-03 0,0156494 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,327E-03 0,01556955 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,327E-03 0,01549052 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 1,328E-03 0,01542197 ! regulation of protein localization GO:0032880 132 85 4,000 1,328E-03 0,01534447 ! negative regulation of multicellular organismal process GO:0051241 133 85 4,000 1,328E-03 0,01526775 ! negative regulation of cell motion GO:0051271 104 51 3,000 1,415E-03 0,0161936 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 1,495E-03 0,01702434 ! aging GO:0007568 79 52 3,000 1,522E-03 0,01724233 ! reproductive developmental process GO:0003006 127 89 4,000 1,629E-03 0,01837163 ! iron ion homeostasis GO:0055072 39 25 2,000 1,687E-03 0,01892981 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,687E-03 0,01883792 ! DNA catabolic process GO:0006308 67 54 3,000 1,752E-03 0,01946297 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 1,846E-03 0,02041097 ! neutral lipid catabolic process GO:0046461 9 7 1,000 1,846E-03 0,02031331 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,846E-03 0,02021658 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,846E-03 0,02012076 ! microtubule bundle formation GO:0001578 8 7 1,000 1,846E-03 0,02002585 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,846E-03 0,01993183 ! glycerolipid catabolic process GO:0046503 9 7 1,000 1,846E-03 0,0198387 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,846E-03 0,01974642 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,846E-03 0,019655 ! asymmetric protein localization GO:0008105 8 7 1,000 1,846E-03 0,01956443 ! organ growth GO:0035265 11 7 1,000 1,846E-03 0,01947468 ! synaptic transmission, glutamatergic GO:0035249 13 7 1,000 1,846E-03 0,01938576 ! behavioral fear response GO:0001662 13 7 1,000 1,846E-03 0,01929764 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 1,846E-03 0,01921032 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,846E-03 0,01912379 ! fibrinolysis GO:0042730 9 7 1,000 1,846E-03 0,01903803 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,846E-03 0,01895304 ! response to tumor cell GO:0002347 12 7 1,000 1,846E-03 0,0188688 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,846E-03 0,01878531 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,846E-03 0,01870256 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 1,000 1,846E-03 0,01862053 ! cell fate commitment GO:0045165 141 92 4,000 1,887E-03 0,0189513 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,894E-03 0,01894002 ! regulation of coagulation GO:0050818 39 26 2,000 1,894E-03 0,01885802 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,894E-03 0,01877674 ! response to oxidative stress GO:0006979 141 94 4,000 2,074E-03 0,0204755 ! response to ionizing radiation GO:0010212 47 27 2,000 2,116E-03 0,02079739 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 2,116E-03 0,02070889 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 2,116E-03 0,02062114 GO:0043433|negative regulation of transcription factor activity, ! regulation of binding GO:0051098 151 95 4,000 2,173E-03 0,02108692 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,353E-03 0,02274212 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 2,353E-03 0,02264697 ! regulation of B cell activation GO:0050864 42 28 2,000 2,353E-03 0,02255261 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,446E-03 0,02334088 ! succinate metabolic process GO:0006105 14 8 1,000 2,446E-03 0,02324443 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,446E-03 0,02314878 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,446E-03 0,02305391 ! melanin metabolic process GO:0006582 12 8 1,000 2,446E-03 0,02295981 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,446E-03 0,02286648 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,446E-03 0,0227739 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,446E-03 0,02268207 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 2,607E-03 0,02407687 ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 2,876E-03 0,02645969 ! spindle organization GO:0007051 37 30 2,000 2,876E-03 0,02635428 ! hindbrain development GO:0030902 45 30 2,000 2,876E-03 0,0262497 ! regulation of transcription factor activity GO:0051090 97 63 3,000 3,087E-03 0,02806753 GO:0090046|regulation of transcription regulator activity, ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,125E-03 0,0282954 ! lung alveolus development GO:0048286 17 9 1,000 3,125E-03 0,02818444 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 3,125E-03 0,02807434 ! T cell selection GO:0045058 18 9 1,000 3,125E-03 0,02796511 ! phosphagen metabolic process GO:0006599 12 9 1,000 3,125E-03 0,02785671 GO:0006600|creatine metabolic process, ! substrate-bound cell migration GO:0006929 10 9 1,000 3,125E-03 0,02774916 ! receptor clustering GO:0043113 15 9 1,000 3,125E-03 0,02764243 ! epithelial cell development GO:0002064 10 9 1,000 3,125E-03 0,02753652 ! motor axon guidance GO:0008045 14 9 1,000 3,125E-03 0,02743142 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 3,125E-03 0,02732712 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 3,125E-03 0,02722361 ! purine base metabolic process GO:0006144 18 9 1,000 3,125E-03 0,02712088 ! oocyte differentiation GO:0009994 12 9 1,000 3,125E-03 0,02701892 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 3,125E-03 0,02691772 ! spleen development GO:0048536 15 9 1,000 3,125E-03 0,02681728 ! embryonic placenta development GO:0001892 12 9 1,000 3,125E-03 0,02671759 ! response to nicotine GO:0035094 16 9 1,000 3,125E-03 0,02661864 ! DNA damage checkpoint GO:0000077 53 31 2,000 3,162E-03 0,02683667 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 3,162E-03 0,02673801 ! metanephros development GO:0001656 58 31 2,000 3,162E-03 0,02664007 ! positive regulation of gene-specific transcription GO:0043193 47 31 2,000 3,162E-03 0,02654284 ! leukocyte chemotaxis GO:0030595 43 31 2,000 3,162E-03 0,02644632 GO:0060326|cell chemotaxis, ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 3,269E-03 0,02724247 ! reproductive structure development GO:0048608 90 65 3,000 3,458E-03 0,02871193 ! regulation of caspase activity GO:0043281 97 65 3,000 3,458E-03 0,02860865 ! regulation of muscle development GO:0048634 48 32 2,000 3,465E-03 0,02856384 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 3,785E-03 0,03109049 ! ear morphogenesis GO:0042471 42 33 2,000 3,785E-03 0,03097985 ! carbohydrate homeostasis GO:0033500 39 33 2,000 3,785E-03 0,03086999 GO:0042593|glucose homeostasis, ! negative regulation of DNA binding GO:0043392 54 33 2,000 3,785E-03 0,03076091 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 3,858E-03 0,03124061 ! negative regulation of muscle development GO:0048635 12 10 1,000 3,882E-03 0,03132475 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,882E-03 0,03121522 ! regulation of cell projection assembly GO:0060491 20 10 1,000 3,882E-03 0,03110646 ! blood vessel remodeling GO:0001974 21 10 1,000 3,882E-03 0,03099845 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 3,882E-03 0,03089119 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 3,882E-03 0,03078467 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,882E-03 0,03067888 ! response to X-ray GO:0010165 16 10 1,000 3,882E-03 0,03057381 ! B cell proliferation GO:0042100 14 10 1,000 3,882E-03 0,03046947 ! nucleobase biosynthetic process GO:0046112 21 10 1,000 3,882E-03 0,03036583 ! fear response GO:0042596 16 10 1,000 3,882E-03 0,03026289 ! negative regulation of ossification GO:0030279 19 10 1,000 3,882E-03 0,03016066 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 3,882E-03 0,0300591 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,882E-03 0,02995823 ! regulation of bone resorption GO:0045124 24 10 1,000 3,882E-03 0,02985804 ! alpha-beta T cell activation GO:0046631 16 10 1,000 3,882E-03 0,02975851 ! cranial nerve development GO:0021545 12 10 1,000 3,882E-03 0,02965965 ! DNA methylation GO:0006306 15 10 1,000 3,882E-03 0,02956144 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 1,000 3,882E-03 0,02946387 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 3,882E-03 0,02936695 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 3,882E-03 0,02927067 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 4,122E-03 0,03098525 ! DNA integrity checkpoint GO:0031570 57 34 2,000 4,122E-03 0,03088432 ! response to drug GO:0042493 108 69 3,000 4,287E-03 0,03201584 ! pigment metabolic process GO:0042440 61 35 2,000 4,478E-03 0,03332814 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 4,514E-03 0,03349007 ! regulation of catabolic process GO:0009894 106 70 3,000 4,514E-03 0,03338238 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,714E-03 0,03475386 ! RNA polyadenylation GO:0043631 19 11 1,000 4,714E-03 0,03464282 ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,714E-03 0,0345325 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 4,714E-03 0,03442287 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 4,714E-03 0,03431394 ! regulation of intracellular pH GO:0051453 17 11 1,000 4,714E-03 0,03420569 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 4,714E-03 0,03409812 ! nitric oxide metabolic process GO:0046209 14 11 1,000 4,714E-03 0,03399123 GO:0006809|nitric oxide biosynthetic process, ! T cell homeostasis GO:0043029 20 11 1,000 4,714E-03 0,03388501 ! regulation of leukocyte migration GO:0002685 24 11 1,000 4,714E-03 0,03377945 ! male genitalia development GO:0030539 13 11 1,000 4,714E-03 0,03367455 ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,714E-03 0,03357029 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! mRNA 3'-end processing GO:0031124 19 11 1,000 4,714E-03 0,03346668 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 4,748E-03 0,03360369 ! response to reactive oxygen species GO:0000302 55 36 2,000 4,851E-03 0,03422291 ! negative regulation of binding GO:0051100 58 36 2,000 4,851E-03 0,03411825 ! tissue remodeling GO:0048771 62 36 2,000 4,851E-03 0,03401423 ! regulation of peptidase activity GO:0052547 106 72 3,000 4,991E-03 0,03489056 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 4,991E-03 0,03478484 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 3,000 5,242E-03 0,03642174 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 5,622E-03 0,03894734 ! cartilage condensation GO:0001502 18 12 1,000 5,622E-03 0,03883038 ! heart looping GO:0001947 15 12 1,000 5,622E-03 0,03871412 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 5,622E-03 0,03859856 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,622E-03 0,03848368 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 5,622E-03 0,03836949 ! autonomic nervous system development GO:0048483 23 12 1,000 5,622E-03 0,03825597 ! gland morphogenesis GO:0022612 23 12 1,000 5,622E-03 0,03814312 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,622E-03 0,03803093 ! regulation of fatty acid oxidation GO:0046320 18 12 1,000 5,622E-03 0,03791941 ! RNA 3'-end processing GO:0031123 20 12 1,000 5,622E-03 0,03780853 ! regulation of T cell proliferation GO:0042129 58 38 2,000 5,652E-03 0,03789969 ! mesenchymal cell development GO:0014031 64 38 2,000 5,652E-03 0,03778952 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! response to nutrient GO:0007584 104 75 3,000 5,768E-03 0,03845309 ! regulation of ligase activity GO:0051340 114 75 3,000 5,768E-03 0,03834195 ! regulation of protein transport GO:0051223 114 76 3,000 6,044E-03 0,04006046 GO:0070201|regulation of establishment of protein localization, ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 6,081E-03 0,04018771 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 6,081E-03 0,04007256 ! male sex differentiation GO:0046661 53 39 2,000 6,081E-03 0,03995807 ! cell growth GO:0016049 61 39 2,000 6,081E-03 0,03984422 ! regulation of DNA binding GO:0051101 119 77 3,000 6,328E-03 0,04135097 ! sex differentiation GO:0007548 105 77 3,000 6,328E-03 0,04123382 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 2,000 6,528E-03 0,04241403 ! T cell differentiation GO:0030217 65 40 2,000 6,528E-03 0,04229455 ! B cell differentiation GO:0030183 62 40 2,000 6,528E-03 0,04217574 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 6,528E-03 0,0420576 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 6,603E-03 0,04241922 ! regulation of chemokine production GO:0032642 17 13 1,000 6,603E-03 0,04230106 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 1,000 6,603E-03 0,04218356 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 6,603E-03 0,0420667 ! genitalia development GO:0048806 15 13 1,000 6,603E-03 0,0419505 ! regulation of cellular pH GO:0030641 20 13 1,000 6,603E-03 0,04183493 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,603E-03 0,04172 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 1,000 6,603E-03 0,0416057 ! lymphocyte homeostasis GO:0002260 24 13 1,000 6,603E-03 0,04149202 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 1,000 6,603E-03 0,04137897 ! positive regulation of protein modification process GO:0031401 107 78 3,000 6,622E-03 0,04138657 ! regulation of T cell differentiation GO:0045580 59 41 2,000 6,995E-03 0,04359835 ! embryonic skeletal system development GO:0048706 56 42 2,000 7,481E-03 0,0465012 ! regulation of cell shape GO:0008360 78 42 2,000 7,481E-03 0,04637586 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 7,655E-03 0,04732937 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 7,655E-03 0,04720249 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 7,655E-03 0,04707628 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 7,655E-03 0,04695074 ! epidermis morphogenesis GO:0048730 29 14 1,000 7,655E-03 0,04682587 ! cellular response to starvation GO:0009267 21 14 1,000 7,655E-03 0,04670166 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 7,655E-03 0,04657811 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 7,655E-03 0,04645522 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 1,000 7,655E-03 0,04633297 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 7,655E-03 0,04621136 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 7,655E-03 0,04609038 ! muscle maintenance GO:0046716 19 14 1,000 7,655E-03 0,04597004 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 7,655E-03 0,04585033 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 7,986E-03 0,04770895 ! leukocyte migration GO:0050900 60 43 2,000 7,986E-03 0,04758535 ! regulation of cell adhesion GO:0030155 159 83 3,000 8,224E-03 0,04887631 ! negative regulation of cell migration GO:0030336 92 44 2,000 8,511E-03 0,05045281 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 8,511E-03 0,05032311 ! regulation of inflammatory response GO:0050727 60 44 2,000 8,511E-03 0,05019407 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 8,572E-03 0,05042478 ! metencephalon development GO:0022037 19 15 1,000 8,778E-03 0,05150138 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 8,778E-03 0,05137033 ! lipid phosphorylation GO:0046834 23 15 1,000 8,778E-03 0,05123995 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 8,778E-03 0,05111023 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 8,778E-03 0,05098116 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 8,778E-03 0,05085275 ! regulation of membrane potential GO:0042391 128 85 3,000 8,93E-03 0,05160536 ! positive regulation of defense response GO:0031349 59 45 2,000 9,056E-03 0,05220312 ! protein amino acid acetylation GO:0006473 28 16 1,000 9,969E-03 0,05732212 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 1,000 9,969E-03 0,05717918 ! regulation of protein binding GO:0043393 27 16 1,000 9,969E-03 0,05703694 ! oogenesis GO:0048477 23 16 1,000 9,969E-03 0,05689541 ! neural crest cell migration GO:0001755 24 16 1,000 9,969E-03 0,05675458 ! G1 phase GO:0051318 27 16 1,000 9,969E-03 0,05661444 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 9,969E-03 0,056475 ! nerve development GO:0021675 18 16 1,000 9,969E-03 0,05633624 ! negative regulation of immune system process GO:0002683 73 47 2,000 0,01020607 0,0575342 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 0,01020607 0,05739353 ! regulation of neurogenesis GO:0050767 153 89 3,000 0,01045811 0,05866743 ! regulation of muscle contraction GO:0006937 69 48 2,000 0,01081136 0,06050155 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 0,01081136 0,0603547 ! protein modification by small protein conjugation GO:0032446 140 90 3,000 0,01086489 0,06050666 ! signal complex assembly GO:0007172 29 17 1,000 0,01122793 0,06237738 ! forelimb morphogenesis GO:0035136 19 17 1,000 0,01122793 0,06222707 ! regulation of viral genome replication GO:0045069 24 17 1,000 0,01122793 0,06207748 ! neuromuscular junction development GO:0007528 23 17 1,000 0,01122793 0,06192862 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 0,01122793 0,06178046 ! nucleobase metabolic process GO:0009112 31 17 1,000 0,01122793 0,06163302 ! positive regulation of growth GO:0045927 67 50 2,000 0,0120832 0,06616988 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,0120832 0,06601271 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 0,01255283 0,06841591 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 0,01255283 0,06825417 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 0,01255283 0,0680932 ! glutamine metabolic process GO:0006541 23 18 1,000 0,01255283 0,06793298 ! response to retinoic acid GO:0032526 25 18 1,000 0,01255283 0,06777351 ! pigmentation during development GO:0048066 31 18 1,000 0,01255283 0,06761479 ! somitogenesis GO:0001756 24 18 1,000 0,01255283 0,06745681 ! gut development GO:0048565 26 18 1,000 0,01255283 0,06729957 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,01255283 0,06714306 ! angiogenesis GO:0001525 149 95 3,000 0,01305179 0,06964995 ! in utero embryonic development GO:0001701 147 96 3,000 0,01352036 0,07198338 ! protein modification by small protein conjugation or removal GO:0070647 148 96 3,000 0,01352036 0,07181714 ! response to light stimulus GO:0009416 153 96 3,000 0,01352036 0,07165166 ! regeneration GO:0031099 32 19 1,000 0,01394242 0,07371854 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,01394242 0,07354946 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 0,01394242 0,07338115 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01394242 0,07321362 ! response to vitamin A GO:0033189 26 19 1,000 0,01394242 0,07304684 ! response to starvation GO:0042594 30 19 1,000 0,01394242 0,07288083 ! renal system process GO:0003014 35 19 1,000 0,01394242 0,07271557 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 0,01394242 0,07255105 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 0,01394242 0,07238728 ! protein stabilization GO:0050821 26 19 1,000 0,01394242 0,07222424 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 0,0139995 0,07235696 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01414559 0,07294811 ! kidney development GO:0001822 90 53 2,000 0,01414559 0,07278491 ! cell projection assembly GO:0030031 76 53 2,000 0,01414559 0,07262245 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01487464 0,07619528 ! extracellular structure organization GO:0043062 156 99 3,000 0,01498983 0,07661467 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 0,01498983 0,07644479 ! response to vitamin GO:0033273 29 20 1,000 0,01539535 0,07833915 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01539535 0,07816622 ! response to ethanol GO:0045471 37 20 1,000 0,01539535 0,07799404 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01539535 0,07782263 ! DNA modification GO:0006304 28 20 1,000 0,01539535 0,07765196 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01539535 0,07748205 ! Ras protein signal transduction GO:0007265 162 100 3,000 0,01550116 0,07784424 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 0,01639556 0,08215641 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 0,01639556 0,08197781 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 0,01639556 0,08179998 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01691029 0,08418543 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01691029 0,08400361 ! dendrite development GO:0016358 35 21 1,000 0,01691029 0,08382256 ! ovarian follicle development GO:0001541 30 21 1,000 0,01691029 0,0836423 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01691029 0,08346281 ! cholesterol biosynthetic process GO:0006695 29 21 1,000 0,01691029 0,08328409 ! platelet activation GO:0030168 28 21 1,000 0,01691029 0,08310613 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01691029 0,08292893 ! nerve-nerve synaptic transmission GO:0007270 36 21 1,000 0,01691029 0,08275249 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01691029 0,08257679 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 1,000 0,01691029 0,08240184 ! secondary metabolic process GO:0019748 84 57 2,000 0,01718754 0,08357577 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 0,01718754 0,08339945 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01848595 0,08951093 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01848595 0,08932288 ! molting cycle process GO:0022404 40 22 1,000 0,01848595 0,08913562 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01848595 0,08894914 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01848595 0,08876345 ! vasculogenesis GO:0001570 33 22 1,000 0,01848595 0,08857852 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01848595 0,08839437 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01848595 0,08821098 ! neural tube closure GO:0001843 33 22 1,000 0,01848595 0,08802834 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein tetramerization GO:0051262 39 22 1,000 0,01848595 0,08784647 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 0,01883475 0,08931944 ! regulation of heart contraction GO:0008016 91 60 2,000 0,01969005 0,09318339 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,02012105 0,09502753 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,02012105 0,0948328 ! myelination GO:0042552 35 23 1,000 0,02012105 0,09463886 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,02012105 0,09444572 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,02012105 0,09425337 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,02012105 0,0940618 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,02012105 0,093871 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,02012105 0,09368098 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 1,000 0,02012105 0,09349173 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,02012105 0,09330324 ! fatty acid biosynthetic process GO:0006633 92 61 2,000 0,02056652 0,09517707 ! extracellular matrix organization GO:0030198 103 61 2,000 0,02056652 0,09498595 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 0,02146417 0,09893305 ! meiotic cell cycle GO:0051321 97 62 2,000 0,02146417 0,09873519 ! positive regulation of cell projection organization GO:0031346 39 24 1,000 0,02181431 0,10014552 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,02181431 0,09994602 ! receptor metabolic process GO:0043112 37 24 1,000 0,02181431 0,09974732 ! neural crest cell development GO:0014032 39 24 1,000 0,02181431 0,09954941 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 1,000 0,02181431 0,09935228 ! negative regulation of cell development GO:0010721 56 24 1,000 0,02181431 0,09915594 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,02181431 0,09896036 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,02181431 0,09876556 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,02181431 0,09857152 ! glutathione metabolic process GO:0006749 29 24 1,000 0,02181431 0,09837824 ! adaptive immune response GO:0002250 94 64 2,000 0,02332304 0,10497648 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 0,02356449 0,10585609 ! male gonad development GO:0008584 33 25 1,000 0,02356449 0,10564975 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,02356449 0,1054442 ! leukocyte proliferation GO:0070661 39 25 1,000 0,02356449 0,10523946 GO:0032943|mononuclear cell proliferation, ! B cell activation GO:0042113 104 65 2,000 0,02428425 0,10824376 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 0,02428425 0,10803439 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,02428425 0,10782583 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,02537036 0,11243127 ! regulation of pH GO:0006885 36 26 1,000 0,02537036 0,11221506 ! post-embryonic development GO:0009791 42 26 1,000 0,02537036 0,11199967 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,02537036 0,11178512 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,0262702 0,11552859 ! inner ear morphogenesis GO:0042472 35 27 1,000 0,02723072 0,11952414 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02723072 0,11929648 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02723072 0,11906968 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,02729488 0,11912379 ! positive regulation of ligase activity GO:0051351 99 69 2,000 0,02834068 0,12345373 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02914436 0,12671462 ! complement activation, classical pathway GO:0006958 36 28 1,000 0,02914436 0,12647554 ! triglyceride metabolic process GO:0006641 34 28 1,000 0,02914436 0,12623736 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02914436 0,12600007 ! mesoderm formation GO:0001707 46 28 1,000 0,02914436 0,12576367 ! sterol biosynthetic process GO:0016126 40 28 1,000 0,02914436 0,12552816 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02914436 0,12529353 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,02914436 0,12505977 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,02914436 0,12482688 ! placenta development GO:0001890 37 28 1,000 0,02914436 0,12459486 ! humoral immune response GO:0006959 86 70 2,000 0,02940755 0,12548678 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,03049546 0,12988807 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,03049546 0,12964798 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,03111013 0,13201714 ! ovulation cycle process GO:0022602 41 29 1,000 0,03111013 0,13177401 ! formation of primary germ layer GO:0001704 48 29 1,000 0,03111013 0,13153178 ! tissue homeostasis GO:0001894 42 29 1,000 0,03111013 0,13129044 GO:0048871|multicellular organismal homeostasis, ! collagen metabolic process GO:0032963 40 30 1,000 0,03312684 0,13954532 ! pigment biosynthetic process GO:0046148 50 30 1,000 0,03312684 0,13929021 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,03312684 0,13903603 ! ovulation cycle GO:0042698 43 30 1,000 0,03312684 0,13878277 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,03312684 0,13853044 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,03312684 0,13827902 ! response to heat GO:0009408 41 30 1,000 0,03312684 0,13802852 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 0,03388491 0,1409318 ! mammary gland development GO:0030879 57 31 1,000 0,03519338 0,14610971 ! glial cell differentiation GO:0010001 55 31 1,000 0,03519338 0,14584645 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,03519338 0,14558413 ! odontogenesis GO:0042476 50 31 1,000 0,03519338 0,14532276 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,03519338 0,14506232 ! segmentation GO:0035282 41 31 1,000 0,03519338 0,14480282 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,03519338 0,14454424 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03519338 0,14428659 ! cell fate specification GO:0001708 37 31 1,000 0,03519338 0,14402985 ! regulation of cell morphogenesis GO:0022604 140 76 2,000 0,03624874 0,14808545 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,03730861 0,15214505 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03730861 0,15187577 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,03730861 0,15160743 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,03730861 0,15134005 ! peripheral nervous system development GO:0007422 53 32 1,000 0,03730861 0,15107361 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,03947143 0,1595506 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,03947143 0,15927068 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,03947143 0,15899175 ! female gonad development GO:0008585 49 33 1,000 0,03947143 0,15871379 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03947143 0,15843681 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,03947143 0,15816078 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,03947143 0,15788572 ! T cell activation GO:0042110 134 79 2,000 0,03994945 0,15952037 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,04168075 0,16614509 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,04168075 0,16585764 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,04168075 0,16557118 ! neuron migration GO:0001764 46 34 1,000 0,04168075 0,16528572 ! female gamete generation GO:0007292 43 34 1,000 0,04168075 0,16500123 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,04168075 0,16471772 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,04168075 0,16443519 ! embryonic organ development GO:0048568 45 34 1,000 0,04168075 0,16415362 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,04393548 0,1727378 ! maintenance of protein location GO:0045185 65 35 1,000 0,04393548 0,17244303 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,04393548 0,17214926 ! glycogen metabolic process GO:0005977 48 35 1,000 0,04393548 0,17185649 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,04393548 0,17156471 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04623459 0,18023653 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,04623459 0,17993156 ! organic ether metabolic process GO:0018904 46 36 1,000 0,04623459 0,17962762 ! neural tube development GO:0021915 50 36 1,000 0,04623459 0,17932471 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04623459 0,17902281 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,04623459 0,17872194 ! glucan metabolic process GO:0044042 49 36 1,000 0,04623459 0,17842207 GO:0006073|cellular glucan metabolic process, ! regulation of defense response GO:0031347 117 84 2,000 0,04652501 0,17924209 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04686481 0,18024927 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04686481 0,17994836 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04686481 0,17964844 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04686481 0,17934953 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04686481 0,1790516 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04686481 0,17875467 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04686481 0,17845872 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04686481 0,17816375 ! sleep GO:0030431 11 5 0,000 0,04686481 0,17786975 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04686481 0,17757672 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04686481 0,17728465 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04686481 0,17699354 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04686481 0,17670339 ! tongue development GO:0043586 6 5 0,000 0,04686481 0,17641418 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04686481 0,17612592 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04686481 0,17583861 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04686481 0,17555222 ! cobalt ion transport GO:0006824 9 5 0,000 0,04686481 0,17526677 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04686481 0,17498225 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04686481 0,17469865 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04686481 0,17441596 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04686481 0,17413419 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04686481 0,17385333 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04686481 0,17357338 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04686481 0,17329432 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04686481 0,17301616 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04686481 0,17273889 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04686481 0,17246251 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04686481 0,17218701 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04686481 0,17191239 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04686481 0,17163864 ! malate metabolic process GO:0006108 7 5 0,000 0,04686481 0,17136576 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04686481 0,17109376 ! behavioral response to pain GO:0048266 7 5 0,000 0,04686481 0,17082261 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04686481 0,17055232 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04686481 0,17028288 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04686481 0,1700143 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04686481 0,16974656 ! mating behavior GO:0007617 6 5 0,000 0,04686481 0,16947966 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04686481 0,1692136 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04686481 0,16894838 ! rhythmic behavior GO:0007622 12 5 0,000 0,04686481 0,16868398 ! copulation GO:0007620 7 5 0,000 0,04686481 0,16842042 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04686481 0,16815767 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04686481 0,16789574 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04686481 0,16763463 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04686481 0,16737433 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04686481 0,16711483 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04686481 0,16685614 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04686481 0,16659825 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04686481 0,16634115 ! response to protozoan GO:0001562 9 5 0,000 0,04686481 0,16608485 ! lymph vessel development GO:0001945 7 5 0,000 0,04686481 0,16582933 ! endochondral ossification GO:0001958 12 5 0,000 0,04686481 0,1655746 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04686481 0,16532065 ! parathyroid gland development GO:0060017 8 5 0,000 0,04686481 0,16506748 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04686481 0,16481509 ! anagen GO:0042640 6 5 0,000 0,04686481 0,16456346 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04686481 0,1643126 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04686481 0,16406251 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04686481 0,16381317 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04686481 0,16356459 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04686481 0,16331677 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04686481 0,16306969 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04686481 0,16282336 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04686481 0,16257778 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04686481 0,16233293 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04686481 0,16208882 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04686481 0,16184544 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04686481 0,1616028 ! ovulation GO:0030728 6 5 0,000 0,04686481 0,16136088 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04686481 0,16111968 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 9 5 0,000 0,04686481 0,1608792 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04686481 0,16063944 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04686481 0,1604004 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04686481 0,16016206 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04686481 0,15992443 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04686481 0,15968751 ! polyol catabolic process GO:0046174 7 5 0,000 0,04686481 0,15945128 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04686481 0,15921575 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04686481 0,15898092 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04686481 0,15874678 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04686481 0,15851333 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04686481 0,15828057 ! urea metabolic process GO:0019627 6 5 0,000 0,04686481 0,15804848 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04686481 0,15781708 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04686481 0,15758635 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04686481 0,1573563 ! neutrophil activation GO:0042119 5 5 0,000 0,04686481 0,15712692 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04686481 0,1568982 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04686481 0,15667015 ! response to food GO:0032094 5 5 0,000 0,04686481 0,15644277 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04686481 0,15621604 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04686481 0,15598997 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04686481 0,15576455 ! forebrain neuron development GO:0021884 7 5 0,000 0,04686481 0,15553978 ! melanosome organization GO:0032438 7 5 0,000 0,04686481 0,15531566 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04686481 0,15509218 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04686481 0,15486935 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04686481 0,15464715 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04686481 0,1544256 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04686481 0,15420467 ! nucleoside transport GO:0015858 6 5 0,000 0,04686481 0,15398438 ! nucleoside salvage GO:0043174 7 5 0,000 0,04686481 0,15376472 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04686481 0,15354568 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04686481 0,15332726 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04686481 0,15310947 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04686481 0,15289229 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04686481 0,15267573 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04686481 0,15245978 ! depyrimidination GO:0045008 8 5 0,000 0,04686481 0,15224444 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04686481 0,15202971 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04686481 0,15181559 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04686481 0,15160206 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04686481 0,15138914 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04686481 0,15117681 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04686481 0,15096508 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,04686481 0,15075394 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04686481 0,15054339 ! monocyte differentiation GO:0030224 8 5 0,000 0,04686481 0,15033343 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04686481 0,15012405 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04686481 0,14991525 ! centrosome duplication GO:0051298 5 5 0,000 0,04686481 0,14970704 ! response to UV-C GO:0010225 6 5 0,000 0,04686481 0,1494994 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04686481 0,14929234 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04686481 0,14908585 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04686481 0,14887993 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04686481 0,14867457 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04686481 0,14846979 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04686481 0,14826557 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04686481 0,1480619 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04686481 0,1478588 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04686481 0,14765625 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04686481 0,14745426 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04686481 0,14725282 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04686481 0,14705193 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04686481 0,14685159 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04686481 0,14665179 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04686481 0,14645254 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04686481 0,14625382 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04686481 0,14605565 ! neural tube patterning GO:0021532 6 5 0,000 0,04686481 0,14585801 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04686481 0,1456609 ! histone demethylation GO:0016577 9 5 0,000 0,04686481 0,14546433 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04686481 0,14526828 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04686481 0,14507277 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,04686481 0,14487778 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04686481 0,14468331 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04686481 0,14448936 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04686481 0,14429594 ! transcription termination GO:0006353 8 5 0,000 0,04686481 0,14410303 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04686481 0,14391064 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04686481 0,14371875 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04686481 0,14352738 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04686481 0,14333652 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04686481 0,14314617 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04686481 0,14295632 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04686481 0,14276697 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04686481 0,14257813 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04686481 0,14238978 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04686481 0,14220193 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04686481 0,14201458 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04686481 0,14182772 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04686481 0,14164135 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04686481 0,14145547 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04686481 0,14127007 ! glial cell migration GO:0008347 10 5 0,000 0,04686481 0,14108516 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04686481 0,14090074 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04686481 0,1407168 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04686481 0,14053333 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04686481 0,14035035 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04686481 0,14016784 ! neural plate development GO:0001840 6 5 0,000 0,04686481 0,1399858 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04686481 0,13980424 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04686481 0,13962314 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04686481 0,13944252 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04686481 0,13926236 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04686481 0,13908267 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04686481 0,13890344 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04686481 0,13872467 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04686481 0,13854636 ! spindle assembly GO:0051225 5 5 0,000 0,04686481 0,13836851 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04686481 0,13819111 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04686481 0,13801417 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04686481 0,13783768 ! organ regeneration GO:0031100 7 5 0,000 0,04686481 0,13766164 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04686481 0,13748605 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04686481 0,13731091 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04686481 0,13713622 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04686481 0,13696196 GO:0055081|anion homeostasis, ! rRNA metabolic process GO:0016072 107 85 2,000 0,04790044 0,13981093 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 2,000 0,04790044 0,13963373 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,04790044 0,13945698 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,04857701 0,14124796 GO:0006956|complement activation, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,04857701 0,14106961 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 0,04857701 0,14089172 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,05071078 0,14689521 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,05071078 0,14671043 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,05096174 0,14725125 ! gliogenesis GO:0042063 71 38 1,000 0,05096174 0,14706649 ! maintenance of location in cell GO:0051651 69 38 1,000 0,05096174 0,1468822 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,05214547 0,15010585 ! protein processing GO:0016485 114 88 2,000 0,05214547 0,14991822 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,05338775 0,15329815 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,05338775 0,153107 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,05338775 0,15291633 ! chromatin remodeling GO:0006338 68 39 1,000 0,05338775 0,15272614 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,05338775 0,15253642 ! developmental growth GO:0048589 62 39 1,000 0,05338775 0,15234717 ! synapse organization GO:0050808 55 39 1,000 0,05338775 0,15215838 ! regulation of T cell activation GO:0050863 128 89 2,000 0,05359968 0,15257334 ! leukocyte differentiation GO:0002521 143 90 2,000 0,05507329 0,15657425 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,05585404 0,1585979 ! peptide metabolic process GO:0006518 56 40 1,000 0,05585404 0,15840235 ! inner ear development GO:0048839 57 40 1,000 0,05585404 0,15820727 ! double-strand break repair GO:0006302 67 40 1,000 0,05585404 0,15801267 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,05585404 0,15781855 ! tRNA transcription GO:0009304 11 6 0,000 0,05597241 0,15795896 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05597241 0,15776538 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05597241 0,15757228 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05597241 0,15737965 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05597241 0,15718749 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05597241 0,1569958 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05597241 0,15680457 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05597241 0,15661381 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05597241 0,15642351 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05597241 0,15623368 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05597241 0,15604431 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05597241 0,15585539 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05597241 0,15566693 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05597241 0,15547893 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05597241 0,15529138 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05597241 0,15510428 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05597241 0,15491763 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05597241 0,15473143 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05597241 0,15454568 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05597241 0,15436038 ! neuron adhesion GO:0007158 9 6 0,000 0,05597241 0,15417551 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05597241 0,15399109 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05597241 0,15380711 ! signal peptide processing GO:0006465 8 6 0,000 0,05597241 0,15362357 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05597241 0,15344047 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05597241 0,1532578 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05597241 0,15307557 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05597241 0,15289377 ! opsonization GO:0008228 8 6 0,000 0,05597241 0,1527124 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05597241 0,15253146 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05597241 0,15235095 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05597241 0,15217087 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05597241 0,15199121 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05597241 0,15181197 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05597241 0,15163316 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05597241 0,15145477 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05597241 0,1512768 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05597241 0,15109924 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05597241 0,1509221 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05597241 0,15074538 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05597241 0,15056907 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05597241 0,15039317 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05597241 0,15021768 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05597241 0,1500426 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05597241 0,14986793 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05597241 0,14969367 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05597241 0,14951981 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05597241 0,14934635 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05597241 0,14917329 ! thymic T cell selection GO:0045061 12 6 0,000 0,05597241 0,14900064 ! protein lipoylation GO:0009249 10 6 0,000 0,05597241 0,14882838 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05597241 0,14865653 ! drug transport GO:0015893 6 6 0,000 0,05597241 0,14848507 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05597241 0,148314 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05597241 0,14814333 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05597241 0,14797305 ! histidine metabolic process GO:0006547 6 6 0,000 0,05597241 0,14780316 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05597241 0,14763366 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05597241 0,14746455 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,05597241 0,14729583 ! adenohypophysis development GO:0021984 10 6 0,000 0,05597241 0,14712749 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05597241 0,14695954 ! hyperosmotic response GO:0006972 8 6 0,000 0,05597241 0,14679196 ! microtubule nucleation GO:0007020 10 6 0,000 0,05597241 0,14662478 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05597241 0,14645797 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05597241 0,14629154 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05597241 0,14612549 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05597241 0,14595981 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05597241 0,14579451 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05597241 0,14562958 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05597241 0,14546503 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,05597241 0,14530085 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05597241 0,14513704 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05597241 0,1449736 ! purine salvage GO:0043101 8 6 0,000 0,05597241 0,14481052 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05597241 0,14464781 ! organic alcohol transport GO:0015850 9 6 0,000 0,05597241 0,14448547 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05597241 0,14432349 ! male sex determination GO:0030238 9 6 0,000 0,05597241 0,14416187 ! carnitine transport GO:0015879 8 6 0,000 0,05597241 0,14400062 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05597241 0,14383972 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05597241 0,14367919 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05597241 0,14351901 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05597241 0,14335919 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05597241 0,14319972 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05597241 0,14304061 ! parturition GO:0007567 12 6 0,000 0,05597241 0,14288186 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05597241 0,14272345 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05597241 0,1425654 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05597241 0,14240769 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05597241 0,14225033 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05597241 0,14209333 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05597241 0,14193666 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,05597241 0,14178034 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05597241 0,14162437 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05597241 0,14146874 ! macrophage differentiation GO:0030225 10 6 0,000 0,05597241 0,14131345 ! astrocyte development GO:0014002 14 6 0,000 0,05597241 0,1411585 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05597241 0,14100389 ! interaction with symbiont GO:0051702 8 6 0,000 0,05597241 0,14084962 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05597241 0,14069569 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05597241 0,14054209 ! eating behavior GO:0042755 6 6 0,000 0,05597241 0,14038883 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05597241 0,1402359 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05597241 0,1400833 ! response to copper ion GO:0046688 9 6 0,000 0,05597241 0,13993104 ! DNA topological change GO:0006265 8 6 0,000 0,05597241 0,1397791 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05597241 0,1396275 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,05597241 0,13947622 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05597241 0,13932527 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05597241 0,13917465 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05597241 0,13902436 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05597241 0,13887438 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05597241 0,13872473 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05597241 0,13857541 ! hair follicle maturation GO:0048820 7 6 0,000 0,05597241 0,1384264 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05597241 0,13827772 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05597241 0,13812935 ! Schwann cell development GO:0014044 14 6 0,000 0,05597241 0,1379813 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05597241 0,13783357 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05597241 0,13768615 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05597241 0,13753905 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05597241 0,13739227 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05597241 0,13724579 ! histone ubiquitination GO:0016574 7 6 0,000 0,05597241 0,13709963 ! regulation of meiosis GO:0040020 10 6 0,000 0,05597241 0,13695378 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05597241 0,13680824 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05597241 0,13666301 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05597241 0,13651808 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05597241 0,13637347 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05597241 0,13622916 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05597241 0,13608515 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05597241 0,13594145 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05597241 0,13579805 ! receptor internalization GO:0031623 9 6 0,000 0,05597241 0,13565496 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05597241 0,13551216 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05597241 0,13536967 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05597241 0,13522747 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05597241 0,13508557 ! protein deubiquitination GO:0016579 8 6 0,000 0,05597241 0,13494398 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05597241 0,13480267 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05597241 0,13466167 ! axonal fasciculation GO:0007413 9 6 0,000 0,05597241 0,13452095 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05597241 0,13438054 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05597241 0,13424041 ! midbrain development GO:0030901 6 6 0,000 0,05597241 0,13410058 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05597241 0,13396103 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05597241 0,13382178 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05597241 0,13368282 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05597241 0,13354414 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05597241 0,13340575 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05597241 0,13326765 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05597241 0,13312984 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05597241 0,13299231 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05597241 0,13285506 ! adult feeding behavior GO:0008343 6 6 0,000 0,05597241 0,1327181 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05597241 0,13258141 ! blastocyst growth GO:0001832 15 6 0,000 0,05597241 0,13244501 ! pigment granule transport GO:0051904 12 6 0,000 0,05597241 0,13230889 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05597241 0,13217305 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05597241 0,13203749 ! catecholamine transport GO:0051937 7 6 0,000 0,05597241 0,13190221 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05597241 0,1317672 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05597241 0,13163247 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05597241 0,13149801 ! protein prenylation GO:0018342 10 6 0,000 0,05597241 0,13136383 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05597241 0,13122992 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05597241 0,13109629 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05597241 0,13096292 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05597241 0,13082983 ! response to virus GO:0009615 122 91 2,000 0,05656618 0,13208347 ! sulfur metabolic process GO:0006790 118 92 2,000 0,05807823 0,1354766 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,05835965 0,13599514 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,05835965 0,13585749 ! endosome transport GO:0016197 71 41 1,000 0,05835965 0,13572012 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,05835965 0,13558303 ! biopolymer methylation GO:0043414 62 41 1,000 0,05835965 0,13544622 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,05835965 0,13530968 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,0609036 0,14106575 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,0609036 0,14092383 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,0609036 0,1407822 ! positive regulation of binding GO:0051099 59 43 1,000 0,06348495 0,14660179 ! vesicle organization GO:0016050 79 43 1,000 0,06348495 0,14645474 ! response to insulin stimulus GO:0032868 63 43 1,000 0,06348495 0,14630799 ! methylation GO:0032259 64 43 1,000 0,06348495 0,14616154 ! protein maturation GO:0051604 129 96 2,000 0,06431533 0,14792526 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,06499351 0,14933573 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06499351 0,14918669 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06499351 0,14903795 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06499351 0,14888951 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06499351 0,14874136 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06499351 0,1485935 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06499351 0,14844594 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06499351 0,14829868 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06499351 0,1481517 ! reproductive behavior GO:0019098 12 7 0,000 0,06499351 0,14800501 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06499351 0,14785862 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,06499351 0,14771251 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06499351 0,1475667 ! oligopeptide transport GO:0006857 11 7 0,000 0,06499351 0,14742117 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06499351 0,14727593 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06499351 0,14713097 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06499351 0,1469863 ! RNA methylation GO:0001510 11 7 0,000 0,06499351 0,14684191 ! pericardium development GO:0060039 8 7 0,000 0,06499351 0,14669781 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06499351 0,14655399 ! fibril organization GO:0043206 13 7 0,000 0,06499351 0,14641045 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06499351 0,14626719 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06499351 0,14612421 ! lipoprotein transport GO:0042953 9 7 0,000 0,06499351 0,14598151 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06499351 0,14583909 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06499351 0,14569694 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06499351 0,14555508 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06499351 0,14541349 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06499351 0,14527217 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06499351 0,14513113 ! chemosensory behavior GO:0007635 9 7 0,000 0,06499351 0,14499036 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06499351 0,14484987 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06499351 0,14470965 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06499351 0,1445697 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06499351 0,14443001 ! reflex GO:0060004 12 7 0,000 0,06499351 0,1442906 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06499351 0,14415146 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06499351 0,14401259 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06499351 0,14387398 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06499351 0,14373564 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06499351 0,14359756 ! spinal cord patterning GO:0021511 7 7 0,000 0,06499351 0,14345976 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06499351 0,14332221 ! adrenal gland development GO:0030325 17 7 0,000 0,06499351 0,14318493 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06499351 0,14304791 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06499351 0,14291115 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06499351 0,14277466 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06499351 0,14263842 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06499351 0,14250244 ! endosome organization GO:0007032 10 7 0,000 0,06499351 0,14236673 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06499351 0,14223127 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06499351 0,14209607 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06499351 0,14196113 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06499351 0,14182644 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06499351 0,141692 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06499351 0,14155783 ! galactose metabolic process GO:0006012 10 7 0,000 0,06499351 0,1414239 ! vesicle fusion GO:0006906 15 7 0,000 0,06499351 0,14129023 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06499351 0,14115681 GO:0045851|pH reduction, ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06499351 0,14102365 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06499351 0,14089073 ! retinol metabolic process GO:0042572 9 7 0,000 0,06499351 0,14075806 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06499351 0,14062565 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06499351 0,14049348 ! rRNA modification GO:0000154 12 7 0,000 0,06499351 0,14036156 ! protein heterooligomerization GO:0051291 10 7 0,000 0,06499351 0,14022989 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06499351 0,14009847 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06499351 0,13996729 ! intermediate filament organization GO:0045109 11 7 0,000 0,06499351 0,13983636 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06499351 0,13970567 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06499351 0,13957522 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06499351 0,13944502 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06499351 0,13931507 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06499351 0,13918535 ! response to tropane GO:0014073 13 7 0,000 0,06499351 0,13905587 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06499351 0,13892664 ! melanosome localization GO:0032400 10 7 0,000 0,06499351 0,13879765 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06499351 0,13866889 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06499351 0,13854038 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06499351 0,1384121 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06499351 0,13828406 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06499351 0,13815625 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06499351 0,13802868 ! mast cell activation GO:0045576 9 7 0,000 0,06499351 0,13790135 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06499351 0,13777425 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,06499351 0,13764739 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06499351 0,13752076 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06499351 0,13739436 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06499351 0,1372682 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06499351 0,13714226 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06499351 0,13701656 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06499351 0,13689108 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06499351 0,13676584 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06499351 0,13664083 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06499351 0,13651604 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06499351 0,13639148 ! neuroblast proliferation GO:0007405 13 7 0,000 0,06499351 0,13626715 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06499351 0,13614305 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06499351 0,13601917 ! diuresis GO:0030146 12 7 0,000 0,06499351 0,13589551 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06499351 0,13577208 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06499351 0,13564888 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06499351 0,1355259 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06499351 0,13540314 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06499351 0,1352806 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06499351 0,13515829 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06499351 0,13503619 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06499351 0,13491432 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06499351 0,13479266 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06499351 0,13467123 ! lymph node development GO:0048535 9 7 0,000 0,06499351 0,13455001 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06499351 0,13442902 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06499351 0,13430823 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06499351 0,13418767 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06499351 0,13406732 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06499351 0,13394719 ! ATP catabolic process GO:0006200 10 7 0,000 0,06499351 0,13382727 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06499351 0,13370757 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06499351 0,13358808 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06499351 0,13346881 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06499351 0,13334975 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06499351 0,1332309 ! muscle adaptation GO:0043500 12 7 0,000 0,06499351 0,13311226 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06499351 0,13299383 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06499351 0,13287561 ! retina homeostasis GO:0001895 9 7 0,000 0,06499351 0,13275761 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06499351 0,13263981 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06499351 0,13252222 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06499351 0,13240484 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06499351 0,13228767 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06499351 0,1321707 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06499351 0,13205394 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06499351 0,13193739 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,06610275 0,13407083 ! regulation of action potential GO:0001508 71 44 1,000 0,06610275 0,1339527 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,06610275 0,13383479 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,06875608 0,13908442 ! cell maturation GO:0048469 60 45 1,000 0,06875608 0,1389622 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,07144404 0,14426803 ! regulation of ossification GO:0030278 71 46 1,000 0,07144404 0,14414147 ! histone modification GO:0016570 68 46 1,000 0,07144404 0,14401515 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0739289 0,14889359 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0739289 0,14876333 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0739289 0,14863329 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0739289 0,14850348 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0739289 0,14837389 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0739289 0,14824453 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0739289 0,1481154 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0739289 0,14798649 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0739289 0,14785781 ! phosphate transport GO:0006817 10 8 0,000 0,0739289 0,14772935 ! N-glycan processing GO:0006491 12 8 0,000 0,0739289 0,14760111 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0739289 0,1474731 ! UTP metabolic process GO:0046051 8 8 0,000 0,0739289 0,1473453 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0739289 0,14721773 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0739289 0,14709038 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0739289 0,14696325 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0739289 0,14683634 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0739289 0,14670965 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0739289 0,14658317 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0739289 0,14645692 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0739289 0,14633088 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0739289 0,14620506 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0739289 0,14607945 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0739289 0,14595406 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0739289 0,14582889 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0739289 0,14570393 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0739289 0,14557918 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0739289 0,14545465 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0739289 0,14533033 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0739289 0,14520622 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0739289 0,14508232 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0739289 0,14495864 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0739289 0,14483516 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0739289 0,1447119 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0739289 0,14458884 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0739289 0,144466 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0739289 0,14434336 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0739289 0,14422093 ! macrophage activation GO:0042116 12 8 0,000 0,0739289 0,14409871 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0739289 0,1439767 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0739289 0,14385489 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,0739289 0,14373329 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0739289 0,14361189 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0739289 0,1434907 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0739289 0,14336971 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0739289 0,14324893 ! ruffle organization GO:0031529 11 8 0,000 0,0739289 0,14312835 ! osteoblast development GO:0002076 13 8 0,000 0,0739289 0,14300797 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0739289 0,1428878 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0739289 0,14276783 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0739289 0,14264805 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0739289 0,14252848 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0739289 0,14240911 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0739289 0,14228994 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0739289 0,14217097 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0739289 0,1420522 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0739289 0,14193362 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0739289 0,14181525 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0739289 0,14169707 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0739289 0,14157908 ! segment specification GO:0007379 10 8 0,000 0,0739289 0,1414613 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0739289 0,14134371 ! cellular extravasation GO:0045123 11 8 0,000 0,0739289 0,14122631 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0739289 0,14110911 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0739289 0,14099211 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0739289 0,14087529 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0739289 0,14075868 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0739289 0,14064225 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0739289 0,14052602 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0739289 0,14040998 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0739289 0,14029413 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0739289 0,14017847 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0739289 0,140063 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0739289 0,13994772 ! icosanoid secretion GO:0032309 12 8 0,000 0,0739289 0,13983263 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0739289 0,13971773 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0739289 0,13960302 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0739289 0,1394885 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0739289 0,13937416 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0739289 0,13926002 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0739289 0,13914606 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0739289 0,13903228 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0739289 0,13891869 ! sterol catabolic process GO:0016127 9 8 0,000 0,0739289 0,13880529 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0739289 0,13869207 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0739289 0,13857904 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0739289 0,13846619 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0739289 0,13835352 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0739289 0,13824104 ! prophase GO:0051324 11 8 0,000 0,0739289 0,13812874 ! S phase GO:0051320 8 8 0,000 0,0739289 0,13801662 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0739289 0,13790469 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0739289 0,13779293 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0739289 0,13768136 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0739289 0,13756997 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0739289 0,13745876 ! hormone catabolic process GO:0042447 13 8 0,000 0,0739289 0,13734772 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0739289 0,13723687 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0739289 0,13712619 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0739289 0,1370157 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0739289 0,13690538 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0739289 0,13679524 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0739289 0,13668527 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0739289 0,13657549 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0739289 0,13646588 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0739289 0,13635644 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0739289 0,13624718 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0739289 0,1361381 ! regulation of embryonic development GO:0045995 16 8 0,000 0,0739289 0,13602918 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0739289 0,13592045 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0739289 0,13581189 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,07416572 0,1361382 ! covalent chromatin modification GO:0016569 75 47 1,000 0,07416572 0,13602964 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,07416572 0,13592124 ! glutamine family amino acid metabolic process GO:0009064 59 47 1,000 0,07416572 0,13581303 ! response to temperature stimulus GO:0009266 62 48 1,000 0,07692026 0,14074511 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,07692026 0,14063323 ! gastrulation GO:0007369 73 48 1,000 0,07692026 0,14052152 ! heart morphogenesis GO:0003007 65 48 1,000 0,07692026 0,14041 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,07692026 0,14029865 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,07692026 0,14018748 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,07692026 0,14007648 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,07970678 0,14503607 ! RNA elongation GO:0006354 62 49 1,000 0,07970678 0,14492142 ! germ cell development GO:0007281 68 49 1,000 0,07970678 0,14480695 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,07970678 0,14469266 ! maintenance of location GO:0051235 84 49 1,000 0,07970678 0,14457854 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,08252443 0,14957146 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,08252443 0,14945369 ! lipid modification GO:0030258 73 50 1,000 0,08252443 0,1493361 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,08277942 0,14967977 ! regulation of developmental growth GO:0048638 13 9 0,000 0,08277942 0,14956219 ! telencephalon cell migration GO:0022029 16 9 0,000 0,08277942 0,14944479 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08277942 0,14932758 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08277942 0,14921055 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08277942 0,14909371 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,08277942 0,14897704 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,08277942 0,14886056 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,08277942 0,14874427 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,08277942 0,14862815 ! GTP metabolic process GO:0046039 9 9 0,000 0,08277942 0,14851222 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08277942 0,14839646 ! social behavior GO:0035176 14 9 0,000 0,08277942 0,14828089 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,08277942 0,1481655 ! artery development GO:0060840 19 9 0,000 0,08277942 0,14805028 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,08277942 0,14793525 ! response to pain GO:0048265 16 9 0,000 0,08277942 0,14782039 ! protein complex disassembly GO:0043241 17 9 0,000 0,08277942 0,14770571 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08277942 0,14759121 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,08277942 0,14747689 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,08277942 0,14736274 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08277942 0,14724877 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08277942 0,14713498 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08277942 0,14702136 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08277942 0,14690792 ! protein targeting to ER GO:0045047 19 9 0,000 0,08277942 0,14679465 ! endoderm development GO:0007492 12 9 0,000 0,08277942 0,14668156 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08277942 0,14656864 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,08277942 0,14645589 ! arginine catabolic process GO:0006527 10 9 0,000 0,08277942 0,14634332 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,08277942 0,14623092 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08277942 0,1461187 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,08277942 0,14600664 ! V(D)J recombination GO:0033151 12 9 0,000 0,08277942 0,14589476 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,08277942 0,14578305 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08277942 0,14567151 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08277942 0,14556014 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08277942 0,14544894 ! mannose metabolic process GO:0006013 9 9 0,000 0,08277942 0,14533791 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08277942 0,14522705 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08277942 0,14511636 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08277942 0,14500584 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08277942 0,14489548 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08277942 0,14478529 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08277942 0,14467527 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,08277942 0,14456542 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08277942 0,14445574 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08277942 0,14434622 ! DNA ligation GO:0006266 14 9 0,000 0,08277942 0,14423686 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,08277942 0,14412768 ! response to amine stimulus GO:0014075 13 9 0,000 0,08277942 0,14401865 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08277942 0,1439098 ! erythrocyte development GO:0048821 11 9 0,000 0,08277942 0,1438011 ! renal water homeostasis GO:0003091 14 9 0,000 0,08277942 0,14369257 ! postreplication repair GO:0006301 11 9 0,000 0,08277942 0,14358421 ! mRNA cleavage GO:0006379 13 9 0,000 0,08277942 0,14347601 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08277942 0,14336797 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08277942 0,14326009 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,08277942 0,14315238 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,08277942 0,14304482 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08277942 0,14293743 ! acid secretion GO:0046717 14 9 0,000 0,08277942 0,1428302 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08277942 0,14272313 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08277942 0,14261623 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,08277942 0,14250948 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08277942 0,14240289 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08277942 0,14229646 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08277942 0,14219019 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,08277942 0,14208408 ! detection of calcium ion GO:0005513 13 9 0,000 0,08277942 0,14197812 ! blastocyst formation GO:0001825 12 9 0,000 0,08277942 0,14187233 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08277942 0,14176669 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08277942 0,14166121 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08277942 0,14155588 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08277942 0,14145071 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08277942 0,1413457 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08277942 0,14124085 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08277942 0,14113615 ! prepulse inhibition GO:0060134 14 9 0,000 0,08277942 0,1410316 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,08277942 0,14092721 ! insulin secretion GO:0030073 17 9 0,000 0,08277942 0,14082297 ! sequestering of metal ion GO:0051238 11 9 0,000 0,08277942 0,14071889 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08277942 0,14061496 ! nucleus localization GO:0051647 15 9 0,000 0,08277942 0,14051119 ! regulation of synapse organization GO:0050807 12 9 0,000 0,08277942 0,14040757 ! localization within membrane GO:0051668 15 9 0,000 0,08277942 0,1403041 ! muscle fiber development GO:0048747 74 51 1,000 0,08537237 0,14459238 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,08537237 0,14448598 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,08824977 0,14924593 ! single fertilization GO:0007338 59 53 1,000 0,09115581 0,1540473 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09154585 0,15459284 ! neuron fate specification GO:0048665 11 10 0,000 0,09154585 0,15447942 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09154585 0,15436617 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,09154585 0,15425308 ! thyroid gland development GO:0030878 19 10 0,000 0,09154585 0,15414015 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,09154585 0,1540274 ! synapsis GO:0007129 13 10 0,000 0,09154585 0,1539148 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,09154585 0,15380238 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,09154585 0,15369011 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09154585 0,15357801 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,09154585 0,15346607 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09154585 0,1533543 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,09154585 0,15324269 ! phospholipid efflux GO:0033700 16 10 0,000 0,09154585 0,15313124 ! hippocampus development GO:0021766 19 10 0,000 0,09154585 0,15301995 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,09154585 0,15290882 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09154585 0,15279786 ! pathogenesis GO:0009405 13 10 0,000 0,09154585 0,15268706 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09154585 0,15257641 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09154585 0,15246593 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09154585 0,15235561 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,09154585 0,15224545 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09154585 0,15213544 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09154585 0,1520256 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,09154585 0,15191591 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09154585 0,15180638 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09154585 0,15169701 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09154585 0,1515878 ! forebrain cell migration GO:0021885 17 10 0,000 0,09154585 0,15147874 ! lipid digestion GO:0044241 15 10 0,000 0,09154585 0,15136984 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09154585 0,1512611 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09154585 0,15115251 ! UV protection GO:0009650 14 10 0,000 0,09154585 0,15104408 ! entry into host cell GO:0030260 20 10 0,000 0,09154585 0,15093581 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09154585 0,15082769 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09154585 0,15071972 ! regulation of organ growth GO:0046620 11 10 0,000 0,09154585 0,15061191 ! response to dsRNA GO:0043331 18 10 0,000 0,09154585 0,15050425 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09154585 0,15039675 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09154585 0,1502894 ! embryonic axis specification GO:0000578 12 10 0,000 0,09154585 0,15018221 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,09154585 0,15007516 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09154585 0,14996827 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09154585 0,14986153 ! fucose catabolic process GO:0019317 16 10 0,000 0,09154585 0,14975494 GO:0042355|L-fucose catabolic process, ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09154585 0,14964851 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,09154585 0,14954222 ! zymogen activation GO:0031638 14 10 0,000 0,09154585 0,14943609 ! salivary gland development GO:0007431 22 10 0,000 0,09154585 0,14933011 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09154585 0,14922427 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09154585 0,14911859 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09154585 0,14901306 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09154585 0,14890767 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09154585 0,14880244 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09154585 0,14869735 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09154585 0,14859241 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,09154585 0,14848762 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09154585 0,14838298 ! detection of bacterium GO:0016045 10 10 0,000 0,09154585 0,14827849 ! embryonic gut development GO:0048566 11 10 0,000 0,09154585 0,14817414 ! activation of innate immune response GO:0002218 10 10 0,000 0,09154585 0,14806994 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09154585 0,14796588 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,09154585 0,14786197 ! developmental induction GO:0031128 13 10 0,000 0,09154585 0,14775821 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,09154585 0,14765459 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,09154585 0,14755112 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,09154585 0,1474478 ! amino acid transport GO:0006865 84 54 1,000 0,0940897 0,15143899 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,0940897 0,15133309 ! detection of external stimulus GO:0009581 66 54 1,000 0,0940897 0,15122734 ! mesoderm development GO:0007498 76 55 1,000 0,09705065 0,15587744 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,09705065 0,15576867 ! rRNA transcription GO:0009303 17 11 0,000 0,10022899 0,16075779 ! respiratory burst GO:0045730 14 11 0,000 0,10022899 0,16064577 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,10022899 0,1605339 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,10022899 0,16042218 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,10022899 0,16031062 ! virus-host interaction GO:0019048 17 11 0,000 0,10022899 0,16019922 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,10022899 0,16008797 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,10022899 0,15997687 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,10022899 0,15986593 ! mating GO:0007618 14 11 0,000 0,10022899 0,15975515 ! T cell proliferation GO:0042098 20 11 0,000 0,10022899 0,15964451 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,10022899 0,15953403 ! bone resorption GO:0045453 16 11 0,000 0,10022899 0,1594237 ! regulated secretory pathway GO:0045055 14 11 0,000 0,10022899 0,15931353 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,10022899 0,15920351 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,10022899 0,15909363 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,10022899 0,15898391 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,10022899 0,15887435 ! syncytium formation GO:0006949 15 11 0,000 0,10022899 0,15876493 ! plasma membrane organization GO:0007009 18 11 0,000 0,10022899 0,15865566 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,10022899 0,15854654 ! mitotic spindle organization GO:0007052 15 11 0,000 0,10022899 0,15843758 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,10022899 0,15832876 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,10022899 0,15822009 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,10022899 0,15811157 ! adult heart development GO:0007512 11 11 0,000 0,10022899 0,15800321 ! temperature homeostasis GO:0001659 16 11 0,000 0,10022899 0,15789498 ! L-glutamate transport GO:0015813 16 11 0,000 0,10022899 0,15778691 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,10022899 0,15767899 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,10022899 0,15757121 ! stem cell development GO:0048864 29 11 0,000 0,10022899 0,15746358 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,10022899 0,15735609 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,10022899 0,15724876 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,10022899 0,15714157 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,10022899 0,15703452 ! vasoconstriction GO:0042310 15 11 0,000 0,10022899 0,15692762 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,10022899 0,15682087 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,10022899 0,15671426 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,10022899 0,1566078 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,10022899 0,15650148 ! ribosome assembly GO:0042255 13 11 0,000 0,10022899 0,1563953 ! histone deacetylation GO:0016575 13 11 0,000 0,10022899 0,15628927 ! chromatin silencing GO:0006342 19 11 0,000 0,10022899 0,15618339 ! nucleosome positioning GO:0016584 13 11 0,000 0,10022899 0,15607764 ! regulation of isotype switching GO:0045191 19 11 0,000 0,10022899 0,15597204 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,10022899 0,15586658 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,10022899 0,15576127 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,10022899 0,15565609 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,10022899 0,15555106 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,10022899 0,15544617 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,10022899 0,15534143 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,10022899 0,15523682 ! cholesterol efflux GO:0033344 19 11 0,000 0,10022899 0,15513235 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,10022899 0,15502803 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,10022899 0,15492384 ! germ cell migration GO:0008354 18 11 0,000 0,10022899 0,1548198 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,10022899 0,15471589 ! defense response to fungus GO:0050832 12 11 0,000 0,10022899 0,15461212 ! lysogeny GO:0030069 18 11 0,000 0,10022899 0,1545085 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,10022899 0,15440501 ! acrosome reaction GO:0007340 13 11 0,000 0,10022899 0,15430166 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,10022899 0,15419845 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,10305062 0,15843343 GO:0048609|reproductive process in a multicellular organism, ! developmental maturation GO:0021700 75 57 1,000 0,10305062 0,1583276 ! gonad development GO:0008406 79 57 1,000 0,10305062 0,15822191 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,10608812 0,16277696 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,10608812 0,16266845 ! lactation GO:0007595 20 12 0,000 0,10882963 0,16676092 ! reproductive cellular process GO:0048610 14 12 0,000 0,10882963 0,1666499 ! tRNA modification GO:0006400 14 12 0,000 0,10882963 0,16653902 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,10882963 0,16642829 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10882963 0,1663177 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10882963 0,16620727 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10882963 0,16609698 ! non-recombinational repair GO:0000726 19 12 0,000 0,10882963 0,16598683 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10882963 0,16587684 ! peroxisomal transport GO:0043574 21 12 0,000 0,10882963 0,16576698 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,10882963 0,16565728 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,10882963 0,16554772 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,10882963 0,1654383 ! palate development GO:0060021 15 12 0,000 0,10882963 0,16532903 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,10882963 0,1652199 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10882963 0,16511091 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10882963 0,16500207 ! arginine metabolic process GO:0006525 13 12 0,000 0,10882963 0,16489338 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,10882963 0,16478482 ! methionine metabolic process GO:0006555 13 12 0,000 0,10882963 0,16467641 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10882963 0,16456814 ! Golgi organization GO:0007030 18 12 0,000 0,10882963 0,16446002 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10882963 0,16435203 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10882963 0,16424419 ! monoamine transport GO:0015844 13 12 0,000 0,10882963 0,16413649 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10882963 0,16402893 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10882963 0,16392151 ! L-amino acid transport GO:0015807 20 12 0,000 0,10882963 0,16381423 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10882963 0,16370709 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10882963 0,1636001 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10882963 0,16349324 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,10882963 0,16338652 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10882963 0,16327994 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10882963 0,1631735 ! cerebellum development GO:0021549 13 12 0,000 0,10882963 0,1630672 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10882963 0,16296103 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,10882963 0,16285501 ! histone methylation GO:0016571 15 12 0,000 0,10882963 0,16274912 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10882963 0,16264337 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10882963 0,16253776 ! regulation of epidermis development GO:0045682 17 12 0,000 0,10882963 0,16243228 ! intestinal absorption GO:0050892 19 12 0,000 0,10882963 0,16232694 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10882963 0,16222174 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,10882963 0,16211667 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10882963 0,16201174 ! microspike assembly GO:0030035 23 12 0,000 0,10882963 0,16190695 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,10882963 0,16180229 ! response to cold GO:0009409 14 12 0,000 0,10882963 0,16169777 ! activation of MAPK activity GO:0000187 84 59 1,000 0,10914964 0,16206854 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,10914964 0,16196398 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,11223445 0,16643407 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,11223445 0,16632683 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,11223445 0,16621973 GO:0035113|embryonic appendage morphogenesis, ! fertilization GO:0009566 68 60 1,000 0,11223445 0,16611277 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,11534184 0,17060208 ! meiosis GO:0007126 96 61 1,000 0,11534184 0,17049244 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 1,000 0,11534184 0,17038294 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,11534184 0,17027358 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,11534184 0,17016436 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,11734854 0,17301388 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11734854 0,17290304 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11734854 0,17279235 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,11734854 0,1726818 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11734854 0,17257139 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11734854 0,17246112 ! lipid localization GO:0010876 24 13 0,000 0,11734854 0,17235099 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11734854 0,172241 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11734854 0,17213115 ! organelle fusion GO:0048284 28 13 0,000 0,11734854 0,17202145 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11734854 0,17191188 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11734854 0,17180245 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,11734854 0,17169316 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11734854 0,17158401 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11734854 0,171475 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11734854 0,17136613 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11734854 0,17125739 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11734854 0,1711488 ! cytokine metabolic process GO:0042107 17 13 0,000 0,11734854 0,17104034 ! NAD metabolic process GO:0019674 21 13 0,000 0,11734854 0,17093201 ! exocrine system development GO:0035272 27 13 0,000 0,11734854 0,17082383 ! bone mineralization GO:0030282 15 13 0,000 0,11734854 0,17071578 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11734854 0,17060787 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11734854 0,1705001 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11734854 0,17039246 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11734854 0,17028495 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11734854 0,17017759 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,11734854 0,17007035 ! tissue regeneration GO:0042246 21 13 0,000 0,11734854 0,16996326 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11734854 0,16985629 ! cofactor transport GO:0051181 19 13 0,000 0,11734854 0,16974947 ! NADP metabolic process GO:0006739 18 13 0,000 0,11734854 0,16964277 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11734854 0,16953621 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11734854 0,16942979 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11734854 0,16932349 ! gas transport GO:0015669 18 13 0,000 0,11734854 0,16921734 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11734854 0,16911131 ! regulation of axon extension GO:0030516 23 13 0,000 0,11734854 0,16900542 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11734854 0,16889966 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11734854 0,16879403 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11734854 0,16868853 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,1184711 0,17019583 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,12162152 0,17461268 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,12162152 0,17450375 ! appendage morphogenesis GO:0035107 93 64 1,000 0,12479244 0,17894178 GO:0035108|limb morphogenesis, ! superoxide anion generation GO:0042554 18 14 0,000 0,12578651 0,18025481 ! neuron maturation GO:0042551 21 14 0,000 0,12578651 0,18014257 ! regulation of S phase GO:0033261 18 14 0,000 0,12578651 0,18003047 ! myotube differentiation GO:0014902 21 14 0,000 0,12578651 0,17991851 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,12578651 0,17980669 ! inositol metabolic process GO:0006020 20 14 0,000 0,12578651 0,17969501 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,12578651 0,17958347 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,12578651 0,17947206 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,12578651 0,1793608 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,12578651 0,17924967 ! gene silencing by RNA GO:0031047 20 14 0,000 0,12578651 0,17913868 ! response to cAMP GO:0051591 19 14 0,000 0,12578651 0,17902783 ! limbic system development GO:0021761 25 14 0,000 0,12578651 0,17891711 ! startle response GO:0001964 21 14 0,000 0,12578651 0,17880653 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,12578651 0,17869609 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,12578651 0,17858578 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,12578651 0,17847561 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,12578651 0,17836558 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,12578651 0,17825568 ! glycine metabolic process GO:0006544 22 14 0,000 0,12578651 0,17814592 ! pituitary gland development GO:0021983 23 14 0,000 0,12578651 0,17803629 ! lysosomal transport GO:0007041 20 14 0,000 0,12578651 0,17792679 ! regulation of heart rate GO:0002027 23 14 0,000 0,12578651 0,17781744 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,12578651 0,17770821 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,12578651 0,17759912 ! embryo implantation GO:0007566 27 14 0,000 0,12578651 0,17749016 ! intermediate filament-based process GO:0045103 24 14 0,000 0,12578651 0,17738134 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,12578651 0,17727265 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,12578651 0,1771641 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,12578651 0,17705567 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,12578651 0,17694738 ! mRNA splice site selection GO:0006376 26 14 0,000 0,12578651 0,17683922 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,12578651 0,1767312 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,12578651 0,1766233 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,12578651 0,17651554 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,12578651 0,17640791 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,12578651 0,17630041 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,12578651 0,17619304 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,12578651 0,1760858 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,12578651 0,17597869 ! cell killing GO:0001906 20 14 0,000 0,12578651 0,17587171 ! cilium assembly GO:0042384 20 14 0,000 0,12578651 0,17576487 ! peptide hormone secretion GO:0030072 23 14 0,000 0,12578651 0,17565815 ! appendage development GO:0048736 94 65 1,000 0,12798318 0,1786173 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,12798318 0,17850898 ! activation of immune response GO:0002253 83 65 1,000 0,12798318 0,1784008 ! protein oligomerization GO:0051259 100 65 1,000 0,12798318 0,17829274 ! axon guidance GO:0007411 99 66 1,000 0,13119307 0,18265379 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,13414429 0,18664964 ! positive regulation of cell size GO:0045793 20 15 0,000 0,13414429 0,18653679 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,13414429 0,18642408 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,13414429 0,18631151 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,13414429 0,18619907 ! skin development GO:0043588 25 15 0,000 0,13414429 0,18608676 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,13414429 0,1859746 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,13414429 0,18586256 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,13414429 0,18575067 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,13414429 0,1856389 ! bile acid metabolic process GO:0008206 22 15 0,000 0,13414429 0,18552727 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,13414429 0,18541578 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,13414429 0,18530442 ! adult walking behavior GO:0007628 25 15 0,000 0,13414429 0,18519319 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,13414429 0,1850821 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,13414429 0,18497114 ! myoblast differentiation GO:0045445 27 15 0,000 0,13414429 0,18486031 ! centrosome cycle GO:0007098 16 15 0,000 0,13414429 0,18474961 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,13414429 0,18463905 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,13414429 0,18452862 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,13414429 0,18441832 ! cerebral cortex development GO:0021987 29 15 0,000 0,13414429 0,18430816 ! response to osmotic stress GO:0006970 22 15 0,000 0,13414429 0,18419812 ! vesicle coating GO:0006901 25 15 0,000 0,13414429 0,18408822 ! DNA integration GO:0015074 22 15 0,000 0,13414429 0,18397845 ! peptide secretion GO:0002790 27 15 0,000 0,13414429 0,18386881 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,13414429 0,18375929 ! regulation of vasodilation GO:0042312 24 15 0,000 0,13414429 0,18364991 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,13414429 0,18354066 ! neuron recognition GO:0008038 22 15 0,000 0,13414429 0,18343154 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,13414429 0,18332255 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,13414429 0,18321369 ! biomineral formation GO:0031214 18 15 0,000 0,13414429 0,18310496 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,13414429 0,18299636 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,13414429 0,18288788 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,13414429 0,18277954 ! dopamine metabolic process GO:0042417 30 15 0,000 0,13414429 0,18267132 ! organic cation transport GO:0015695 19 15 0,000 0,13414429 0,18256323 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,13414429 0,18245527 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,13414429 0,18234743 ! peptide hormone processing GO:0016486 19 15 0,000 0,13414429 0,18223973 ! acute inflammatory response GO:0002526 92 68 1,000 0,13766773 0,18691604 ! learning or memory GO:0007611 123 68 1,000 0,13766773 0,18680577 ! rhythmic process GO:0048511 105 68 1,000 0,13766773 0,18669562 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,14093122 0,19100873 ! protein secretion GO:0009306 27 16 0,000 0,14242263 0,19291641 ! hormone secretion GO:0046879 25 16 0,000 0,14242263 0,19280286 ! bone remodeling GO:0046849 24 16 0,000 0,14242263 0,19268944 ! endothelial cell migration GO:0043542 22 16 0,000 0,14242263 0,19257616 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,14242263 0,19246302 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14242263 0,19235 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14242263 0,19223712 ! glial cell development GO:0021782 24 16 0,000 0,14242263 0,19212437 ! patterning of blood vessels GO:0001569 24 16 0,000 0,14242263 0,19201176 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,14242263 0,19189927 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,14242263 0,19178692 ! protein polyubiquitination GO:0000209 26 16 0,000 0,14242263 0,1916747 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14242263 0,19156261 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,14242263 0,19145065 GO:0030968|endoplasmic reticulum unfolded protein response, ! fructose metabolic process GO:0006000 20 16 0,000 0,14242263 0,19133882 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,14242263 0,19122712 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,14242263 0,19111555 ! protein export from nucleus GO:0006611 24 16 0,000 0,14242263 0,19100411 ! negative regulation of immune response GO:0050777 28 16 0,000 0,14242263 0,19089281 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,14242263 0,19078163 ! DNA replication initiation GO:0006270 25 16 0,000 0,14242263 0,19067058 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14242263 0,19055966 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,14242263 0,19044887 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,14242263 0,19033821 ! diencephalon development GO:0021536 25 16 0,000 0,14242263 0,19022767 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14242263 0,19011727 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,14242263 0,19000699 ! steroid catabolic process GO:0006706 22 16 0,000 0,14242263 0,18989684 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14242263 0,18978682 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,14242263 0,18967693 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14242263 0,18956716 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14242263 0,18945752 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14242263 0,18934801 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,14242263 0,18923862 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,14242263 0,18912936 ! negative regulation of translation GO:0017148 22 16 0,000 0,14242263 0,18902023 ! response to metal ion GO:0010038 103 70 1,000 0,14421133 0,19128377 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,14421133 0,19117352 ! amine transport GO:0015837 101 70 1,000 0,14421133 0,1910634 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,14421133 0,1909534 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,14750744 0,19520547 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,14750744 0,19509322 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,1506223 0,19909845 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,1506223 0,19898409 ! negative regulation of defense response GO:0031348 19 17 0,000 0,1506223 0,19886986 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,1506223 0,19875576 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,1506223 0,1986418 ! glycerol metabolic process GO:0006071 20 17 0,000 0,1506223 0,19852796 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,1506223 0,19841426 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,1506223 0,19830068 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,1506223 0,19818724 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,1506223 0,19807393 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,1506223 0,19796074 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,1506223 0,19784768 ! memory GO:0007613 25 17 0,000 0,1506223 0,19773476 ! keratinization GO:0031424 17 17 0,000 0,1506223 0,19762196 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,1506223 0,19750929 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,1506223 0,19739675 ! retinoid metabolic process GO:0001523 22 17 0,000 0,1506223 0,19728434 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,1506223 0,19717205 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,1506223 0,19705989 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,1506223 0,19694787 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,1506223 0,19683596 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,1506223 0,19672419 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,1506223 0,19661254 ! membrane budding GO:0006900 29 17 0,000 0,1506223 0,19650102 ! heme metabolic process GO:0042168 27 17 0,000 0,1506223 0,19638962 ! body fluid secretion GO:0007589 27 17 0,000 0,1506223 0,19627835 ! stem cell differentiation GO:0048863 36 17 0,000 0,1506223 0,19616721 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,1506223 0,19605619 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,1506223 0,1959453 ! sensory perception of pain GO:0019233 23 17 0,000 0,1506223 0,19583454 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,1506223 0,1957239 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,1506223 0,19561338 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,1506223 0,19550299 ! synaptogenesis GO:0007416 24 17 0,000 0,1506223 0,19539272 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,1506223 0,19528258 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,1506223 0,19517256 ! cell-cell junction organization GO:0045216 25 17 0,000 0,1506223 0,19506267 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,1506223 0,1949529 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,1506223 0,19484325 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,1506223 0,19473372 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,1506223 0,19462432 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,15081896 0,19476901 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,15414529 0,19895296 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,15414529 0,19884137 ! protein import into nucleus GO:0006606 118 74 1,000 0,15748586 0,2030367 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,15748586 0,20292295 ! positive regulation of translation GO:0045727 28 18 0,000 0,15874404 0,20442961 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,15874404 0,20431521 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,15874404 0,20420094 ! cAMP metabolic process GO:0046058 33 18 0,000 0,15874404 0,2040868 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,15874404 0,20397278 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,15874404 0,2038589 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,15874404 0,20374514 ! axis specification GO:0009798 26 18 0,000 0,15874404 0,2036315 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,15874404 0,20351799 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,15874404 0,20340461 ! pancreas development GO:0031016 26 18 0,000 0,15874404 0,20329136 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,15874404 0,20317823 ! central nervous system neuron development GO:0021954 30 18 0,000 0,15874404 0,20306523 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,15874404 0,20295235 ! fucose metabolic process GO:0006004 26 18 0,000 0,15874404 0,2028396 ! response to fungus GO:0009620 19 18 0,000 0,15874404 0,20272698 ! peptide cross-linking GO:0018149 31 18 0,000 0,15874404 0,20261447 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,15874404 0,2025021 ! heart process GO:0003015 27 18 0,000 0,15874404 0,20238985 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,15874404 0,20227772 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,15874404 0,20216572 ! visual learning GO:0008542 35 18 0,000 0,15874404 0,20205384 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,15874404 0,20194208 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,15874404 0,20183045 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,15874404 0,20171894 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,15874404 0,20160755 ! vitamin transport GO:0051180 24 18 0,000 0,15874404 0,20149629 ! hormone transport GO:0009914 27 18 0,000 0,15874404 0,20138515 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,15874404 0,20127414 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,15874404 0,20116324 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,15874404 0,20105247 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,15874404 0,20094182 ! cell-cell recognition GO:0009988 20 18 0,000 0,15874404 0,20083129 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,15874404 0,20072088 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,15874404 0,20061059 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,15874404 0,20050043 ! blood coagulation GO:0007596 116 75 1,000 0,16084009 0,20303633 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,16084009 0,20292496 ! nuclear import GO:0051170 121 75 1,000 0,16084009 0,20281371 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,16678857 0,21019929 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,16678857 0,21008418 ! positive regulation of ossification GO:0045778 30 19 0,000 0,16678857 0,20996919 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,16678857 0,20985433 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,16678857 0,20973959 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,16678857 0,20962498 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,16678857 0,20951049 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,16678857 0,20939613 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,16678857 0,20928189 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,16678857 0,20916778 ! sensory perception of taste GO:0050909 23 19 0,000 0,16678857 0,20905379 ! smooth muscle contraction GO:0006939 36 19 0,000 0,16678857 0,20893993 ! peroxisome organization GO:0007031 29 19 0,000 0,16678857 0,20882619 ! digestive system process GO:0022600 30 19 0,000 0,16678857 0,20871257 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,16678857 0,20859908 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,16678857 0,20848571 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,16678857 0,20837247 ! sex determination GO:0007530 29 19 0,000 0,16678857 0,20825934 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,16678857 0,20814634 ! plasma membrane fusion GO:0045026 23 19 0,000 0,16678857 0,20803347 ! cytolysis GO:0019835 20 19 0,000 0,16678857 0,20792071 ! vasodilation GO:0042311 33 19 0,000 0,16678857 0,20780808 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,16678857 0,20769557 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,16678857 0,20758318 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,16678857 0,20747091 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,16678857 0,20735876 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,16678857 0,20724674 ! sarcomere organization GO:0045214 23 19 0,000 0,16678857 0,20713483 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,16678857 0,20702305 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,16678857 0,20691139 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,16678857 0,20679984 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,16678857 0,20668842 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,16678857 0,20657712 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,16678857 0,20646594 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,1675873 0,20734309 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,1675873 0,20723161 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,1675873 0,20712026 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,1709792 0,2111988 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,17438257 0,21528712 ! regulation of lyase activity GO:0051339 133 79 1,000 0,17438257 0,21517163 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,17475663 0,21551757 ! iron ion transport GO:0006826 37 20 0,000 0,17475663 0,21540207 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,17475663 0,21528669 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,17475663 0,21517144 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,17475663 0,21505632 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,17475663 0,21494131 ! spinal cord development GO:0021510 31 20 0,000 0,17475663 0,21482643 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,17475663 0,21471168 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,17475663 0,21459704 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,17475663 0,21448253 ! chromosome condensation GO:0030261 31 20 0,000 0,17475663 0,21436814 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,17475663 0,21425387 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,17475663 0,21413972 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,17475663 0,2140257 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,17475663 0,21391179 ! pallium development GO:0021543 38 20 0,000 0,17475663 0,21379801 ! collagen fibril organization GO:0030199 45 20 0,000 0,17475663 0,21368435 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,17475663 0,21357081 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,17475663 0,21345739 ! collagen catabolic process GO:0030574 25 20 0,000 0,17475663 0,21334409 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,17475663 0,21323091 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,17475663 0,21311785 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,17475663 0,21300491 ! alditol metabolic process GO:0019400 24 20 0,000 0,17475663 0,21289209 ! actin filament-based movement GO:0030048 34 20 0,000 0,17475663 0,21277939 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,17779689 0,21636659 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,17779689 0,21625217 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,17779689 0,21613787 ! forebrain development GO:0030900 131 80 1,000 0,17779689 0,21602369 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,18122165 0,22006853 ! hemostasis GO:0007599 125 81 1,000 0,18122165 0,2199524 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,18122165 0,21983639 ! response to protein stimulus GO:0051789 111 81 1,000 0,18122165 0,2197205 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,18122165 0,21960474 GO:0002696|positive regulation of leukocyte activation, ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,18264895 0,22121779 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,18264895 0,22110136 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,18264895 0,22098505 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,18264895 0,22086887 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,18264895 0,22075281 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,18264895 0,22063686 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,18264895 0,22052104 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,18264895 0,22040535 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,18264895 0,22028977 ! vesicle docking GO:0048278 27 21 0,000 0,18264895 0,22017431 ! phototransduction GO:0007602 25 21 0,000 0,18264895 0,22005898 ! visual behavior GO:0007632 39 21 0,000 0,18264895 0,21994376 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,18264895 0,21982867 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,18264895 0,2197137 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,18264895 0,21959884 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,18264895 0,21948411 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,18264895 0,2193695 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,18264895 0,219255 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,18264895 0,21914063 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,18264895 0,21902638 GO:0060415|muscle tissue morphogenesis, ! leukotriene metabolic process GO:0006691 28 21 0,000 0,18264895 0,21891224 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,18264895 0,21879822 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,18264895 0,21868433 ! fatty acid transport GO:0015908 30 21 0,000 0,18264895 0,21857055 ! immunoglobulin production GO:0002377 33 21 0,000 0,18264895 0,21845688 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,18264895 0,21834334 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,18264895 0,21822992 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,18264895 0,21811661 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,18264895 0,21800342 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,18264895 0,21789035 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,18264895 0,21777739 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,18264895 0,21766455 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,18264895 0,21755183 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,18264895 0,21743923 ! ossification GO:0001503 134 82 1,000 0,18465634 0,21971525 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,18465634 0,21960164 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,18810045 0,22358193 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,19046624 0,22627704 ! viral genome replication GO:0019079 29 22 0,000 0,19046624 0,22616022 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,19046624 0,22604352 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,19046624 0,22592694 ! leukocyte adhesion GO:0007159 38 22 0,000 0,19046624 0,22581049 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,19046624 0,22569415 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,19046624 0,22557793 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,19046624 0,22546184 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,19046624 0,22534586 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,19046624 0,22523 ! lysosome organization GO:0007040 37 22 0,000 0,19046624 0,22511426 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,19046624 0,22499864 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,19046624 0,22488313 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,19046624 0,22476775 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,19046624 0,22465248 ! membrane depolarization GO:0051899 35 22 0,000 0,19046624 0,22453734 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,19046624 0,22442231 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,19046624 0,2243074 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,19046624 0,2241926 ! blastocyst development GO:0001824 37 22 0,000 0,19046624 0,22407793 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,19046624 0,22396337 ! sterol metabolic process GO:0016125 120 84 1,000 0,19155351 0,22512677 ! neuron fate commitment GO:0048663 32 23 0,000 0,1982092 0,23283001 ! embryonic pattern specification GO:0009880 31 23 0,000 0,1982092 0,23271116 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,1982092 0,23259243 ! vesicle targeting GO:0006903 32 23 0,000 0,1982092 0,23247382 ! osteoblast differentiation GO:0001649 40 23 0,000 0,1982092 0,23235533 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,1982092 0,23223696 ! interaction with host GO:0051701 37 23 0,000 0,1982092 0,23211872 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,1982092 0,23200059 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,1982092 0,23188258 ! glycolipid metabolic process GO:0006664 36 23 0,000 0,1982092 0,2317647 ! cell fate determination GO:0001709 45 23 0,000 0,1982092 0,23164693 ! pentose metabolic process GO:0019321 31 23 0,000 0,1982092 0,23152928 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,1982092 0,23141176 ! spermatid development GO:0007286 33 23 0,000 0,1982092 0,23129435 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,1982092 0,23117706 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,1982092 0,23105989 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,1982092 0,23094284 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,1982092 0,2308259 ! telomere organization GO:0032200 32 23 0,000 0,1982092 0,23070909 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,1982092 0,23059239 ! regulation of amine transport GO:0051952 38 23 0,000 0,1982092 0,23047581 ! liver development GO:0001889 40 23 0,000 0,1982092 0,23035935 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,19848454 0,23056285 ! female pregnancy GO:0007565 130 87 1,000 0,20196157 0,2344834 ! initiation of viral infection GO:0019059 42 24 0,000 0,20587854 0,23891052 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,20587854 0,23879004 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,20587854 0,23866968 ! superoxide metabolic process GO:0006801 32 24 0,000 0,20587854 0,23854945 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,20587854 0,23842933 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,20587854 0,23830934 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,20587854 0,23818946 ! sperm motility GO:0030317 27 24 0,000 0,20587854 0,23806971 ! vacuole organization GO:0007033 39 24 0,000 0,20587854 0,23795008 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,20587854 0,23783056 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,20587854 0,23771117 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,20587854 0,2375919 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,20587854 0,23747274 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,20587854 0,23735371 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,20893638 0,24075835 ! hormone metabolic process GO:0042445 121 90 1,000 0,21243327 0,24466525 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,21347496 0,24574195 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,21347496 0,24561902 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,21347496 0,24549621 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,21347496 0,24537352 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,21347496 0,24525096 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,21347496 0,24512851 ! peptide transport GO:0015833 43 25 0,000 0,21347496 0,24500619 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,21347496 0,244884 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,21347496 0,24476192 ! phospholipid transport GO:0015914 35 25 0,000 0,21347496 0,24463997 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,21347496 0,24451813 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,21347496 0,24439642 ! detection of light stimulus GO:0009583 30 25 0,000 0,21347496 0,24427483 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,21347496 0,24415336 GO:0045840|positive regulation of mitosis, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,21944385 0,25085529 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,21944385 0,25073067 ! positive regulation of immune response GO:0050778 121 92 1,000 0,21944385 0,25060618 ! DNA recombination GO:0006310 146 92 1,000 0,21944385 0,25048181 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,22099915 0,25213196 ! translational initiation GO:0006413 43 26 0,000 0,22099915 0,25200696 ! circadian rhythm GO:0007623 42 26 0,000 0,22099915 0,25188208 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,22099915 0,25175732 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,22099915 0,25163269 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,22099915 0,25150818 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,22099915 0,2513838 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,22099915 0,25125953 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,22099915 0,25113539 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,22099915 0,25101138 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,22295669 0,25310977 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,22295669 0,2529849 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,22845178 0,25909225 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,22845178 0,25896456 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,22845178 0,25883699 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,22845178 0,25870955 ! membrane docking GO:0022406 39 27 0,000 0,22845178 0,25858223 ! catechol metabolic process GO:0009712 43 27 0,000 0,22845178 0,25845504 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,22845178 0,25832797 ! acute-phase response GO:0006953 42 27 0,000 0,22845178 0,25820103 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,22845178 0,25807421 ! myofibril assembly GO:0030239 36 27 0,000 0,22845178 0,25794752 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,22845178 0,25782095 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,22845178 0,2576945 ! natural killer cell activation GO:0030101 35 27 0,000 0,22845178 0,25756818 ! lipid oxidation GO:0034440 38 27 0,000 0,22845178 0,25744198 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,22845178 0,25731591 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,22845178 0,25718996 ! gene silencing GO:0016458 41 27 0,000 0,22845178 0,25706413 ! carboxylic acid transport GO:0046942 147 95 1,000 0,22999545 0,25867459 GO:0015849|organic acid transport, ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,23352056 0,26251089 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,23583353 0,2649815 ! phenol metabolic process GO:0018958 44 28 0,000 0,23583353 0,26485211 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,23583353 0,26472285 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,23583353 0,26459372 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,23583353 0,26446471 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,23583353 0,26433583 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,23583353 0,26420708 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,23583353 0,26407845 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,23583353 0,26394994 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,23583353 0,26382156 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,23583353 0,26369331 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,23583353 0,26356517 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,23583353 0,26343717 ! BMP signaling pathway GO:0030509 40 28 0,000 0,23583353 0,26330929 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,23583353 0,26318153 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,23583353 0,26305389 ! regulation of innate immune response GO:0045088 38 29 0,000 0,24314509 0,27107789 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,24314509 0,27094656 ! protein targeting to membrane GO:0006612 53 29 0,000 0,24314509 0,27081535 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,24314509 0,27068427 ! mismatch repair GO:0006298 34 29 0,000 0,24314509 0,27055331 ! muscle cell development GO:0055001 38 29 0,000 0,24314509 0,27042248 ! telencephalon development GO:0021537 52 29 0,000 0,24314509 0,27029178 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,24314509 0,27016121 ! eye morphogenesis GO:0048592 51 29 0,000 0,24314509 0,27003076 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,24314509 0,26990043 ! protein import GO:0017038 156 99 1,000 0,24411416 0,27084543 ! regulation of translation GO:0006417 151 100 1,000 0,2476502 0,27463619 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,2476502 0,27450384 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,2476502 0,27437161 ! protein localization in organelle GO:0033365 161 100 1,000 0,2476502 0,27423951 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,25038709 0,27713682 ! organic anion transport GO:0015711 51 30 0,000 0,25038709 0,27700352 ! cholesterol transport GO:0030301 46 30 0,000 0,25038709 0,27687034 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,25038709 0,2767373 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,25038709 0,27660438 ! ceramide metabolic process GO:0006672 43 30 0,000 0,25038709 0,27647159 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,25038709 0,27633892 ! adult locomotory behavior GO:0008344 47 30 0,000 0,25038709 0,27620639 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,25038709 0,27607398 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,25038709 0,27594169 ! negative regulation of secretion GO:0051048 49 31 0,000 0,25756022 0,28371097 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,25756022 0,28357516 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,25756022 0,28343947 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,25756022 0,28330392 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,25756022 0,2831685 ! RNA modification GO:0009451 40 31 0,000 0,25756022 0,28303321 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,26466511 0,29070189 ! meiosis I GO:0007127 52 32 0,000 0,26466511 0,29056313 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,26466511 0,2904245 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,26466511 0,290286 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,26466511 0,29014764 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,26466511 0,29000941 ! cytokine production GO:0001816 44 32 0,000 0,26466511 0,28987131 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,26466511 0,28973334 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,26466511 0,2895955 ! vesicle localization GO:0051648 47 32 0,000 0,26466511 0,2894578 ! RNA export from nucleus GO:0006405 44 33 0,000 0,27170241 0,29701309 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,27170241 0,29687199 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,27170241 0,29673103 ! sister chromatid segregation GO:0000819 46 33 0,000 0,27170241 0,2965902 ! actomyosin structure organization GO:0031032 43 33 0,000 0,27170241 0,2964495 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,27170241 0,29630893 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,27170241 0,2961685 ! lipid homeostasis GO:0055088 55 33 0,000 0,27170241 0,29602821 ! regulation of proteolysis GO:0030162 50 33 0,000 0,27170241 0,29588804 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,27170241 0,29574801 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,27170241 0,29560811 ! cytokinesis GO:0000910 52 33 0,000 0,27170241 0,29546834 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,27170241 0,29532871 ! mRNA catabolic process GO:0006402 48 34 0,000 0,27867276 0,3027621 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,27867276 0,30261915 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,27867276 0,30247634 ! feeding behavior GO:0007631 45 34 0,000 0,27867276 0,30233366 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,27867276 0,30219112 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,27867276 0,30204871 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,27867276 0,30190643 ! polyol metabolic process GO:0019751 44 34 0,000 0,27867276 0,30176429 ! aerobic respiration GO:0009060 47 34 0,000 0,27867276 0,30162229 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,27867276 0,30148041 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,2855768 0,30880425 ! Notch signaling pathway GO:0007219 56 35 0,000 0,2855768 0,30865914 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,2855768 0,30851416 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,2855768 0,30836932 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,2855768 0,30822461 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,2855768 0,30808004 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,2855768 0,3079356 GO:0015986|ATP synthesis coupled proton transport, ! protein homooligomerization GO:0051260 52 35 0,000 0,2855768 0,3077913 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,29241515 0,31501398 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,29241515 0,3148665 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,29241515 0,31471916 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,29918843 0,32185846 ! learning GO:0007612 67 37 0,000 0,29918843 0,32170799 ! ion transmembrane transport GO:0034220 56 37 0,000 0,29918843 0,32155766 ! regulation of protein secretion GO:0050708 51 37 0,000 0,29918843 0,32140747 ! amino acid activation GO:0043038 52 37 0,000 0,29918843 0,32125742 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,29918843 0,32110751 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,30589726 0,32815471 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,30589726 0,32800173 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,30589726 0,32784888 ! phagocytosis GO:0006909 60 38 0,000 0,30589726 0,32769618 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,31254225 0,33465883 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,31254225 0,3345031 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,31254225 0,33434752 ! JNK cascade GO:0007254 54 39 0,000 0,31254225 0,33419208 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,319124 0,34107119 ! response to calcium ion GO:0051592 58 40 0,000 0,319124 0,34091277 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,319124 0,3407545 ! regulation of tube size GO:0035150 60 40 0,000 0,319124 0,34059638 GO:0050880|regulation of blood vessel size, ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,319124 0,3404384 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,319124 0,34028057 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,32564311 0,34707097 ! glucose transport GO:0015758 52 41 0,000 0,32564311 0,34691021 ! striated muscle contraction GO:0006941 62 41 0,000 0,32564311 0,3467496 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,32564311 0,34658915 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,33210017 0,35329805 ! hexose transport GO:0008645 54 42 0,000 0,33210017 0,35313471 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,33210017 0,35297153 ! excretion GO:0007588 63 42 0,000 0,33210017 0,35280849 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,33210017 0,35264561 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,33210017 0,35248287 ! neuromuscular process GO:0050905 79 43 0,000 0,33849577 0,35910529 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,33849577 0,35893973 ! tRNA processing GO:0008033 49 43 0,000 0,33849577 0,35877432 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,33849577 0,35860906 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,34483049 0,36515199 ! glycolysis GO:0006096 53 44 0,000 0,34483049 0,36498395 ! regulation of ion transport GO:0043269 57 44 0,000 0,34483049 0,36481606 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,34483049 0,36464833 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,34483049 0,36448076 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,34483049 0,36431333 ! positive regulation of cell cycle GO:0045787 77 45 0,000 0,35110491 0,37077194 ! RNA catabolic process GO:0006401 64 45 0,000 0,35110491 0,37060178 ! regulation of translational initiation GO:0006446 64 45 0,000 0,35110491 0,37043178 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,35110491 0,37026194 ! cell recognition GO:0008037 58 45 0,000 0,35110491 0,37009225 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,35731959 0,37647048 ! cell redox homeostasis GO:0045454 63 46 0,000 0,35731959 0,37629811 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,35731959 0,37612589 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,35731959 0,37595383 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,36347511 0,38225549 ! viral infectious cycle GO:0019058 71 47 0,000 0,36347511 0,38208079 ! endocrine system development GO:0035270 83 47 0,000 0,36347511 0,38190624 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,36347511 0,38173185 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,36347511 0,38155763 ! chloride transport GO:0006821 67 48 0,000 0,36957202 0,38778086 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,36957202 0,38760404 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,36957202 0,38742737 ! regulation of endocytosis GO:0030100 63 48 0,000 0,36957202 0,38725087 ! nuclear export GO:0051168 69 48 0,000 0,36957202 0,38707452 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,37561088 0,39322031 ! sensory perception of smell GO:0007608 61 49 0,000 0,37561088 0,39304142 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,37561088 0,39286268 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,37561088 0,39268411 ! regulation of actin filament length GO:0030832 72 50 0,000 0,38159224 0,39875609 ! membrane fusion GO:0006944 80 50 0,000 0,38159224 0,398575 ! proton transport GO:0015992 75 50 0,000 0,38159224 0,39839408 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,38159224 0,39821332 ! positive regulation of secretion GO:0051047 71 51 0,000 0,38751664 0,40421236 ! hydrogen transport GO:0006818 77 51 0,000 0,38751664 0,40402913 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,38751664 0,40384606 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,38751664 0,40366316 ! adult behavior GO:0030534 80 51 0,000 0,38751664 0,40348043 ! transition metal ion transport GO:0000041 74 52 0,000 0,39338461 0,4094048 ! regulation of cellular component size GO:0032535 74 52 0,000 0,39338461 0,40921964 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,39338461 0,40903464 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,39338461 0,4088498 ! establishment of organelle localization GO:0051656 85 52 0,000 0,39338461 0,40866514 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,39919671 0,41451577 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,39919671 0,41432871 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,40495344 0,42011408 ! regulation of mitosis GO:0007088 84 54 0,000 0,40495344 0,41992467 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,40495344 0,41973543 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,40495344 0,41954636 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,40495344 0,41935746 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,40495344 0,41916873 ! exocytosis GO:0006887 74 55 0,000 0,41065535 0,42487958 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,41065535 0,42468853 ! carbohydrate transport GO:0008643 74 57 0,000 0,42189673 0,43611797 ! chromosome segregation GO:0007059 83 57 0,000 0,42189673 0,43592205 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,42189673 0,4357263 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,42189673 0,43553073 ! camera-type eye development GO:0043010 88 57 0,000 0,42189673 0,43533534 ! viral reproductive process GO:0022415 87 58 0,000 0,42743723 0,44085454 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,42743723 0,44065694 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,43292495 0,44611442 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,43836038 0,45151315 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,43836038 0,45131104 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,43836038 0,45110912 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,44374402 0,4564451 ! amine catabolic process GO:0009310 90 62 0,000 0,44907636 0,46172358 ! neurotransmitter transport GO:0006836 81 62 0,000 0,44907636 0,46151726 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,44907636 0,46131114 ! organelle localization GO:0051640 96 62 0,000 0,44907636 0,4611052 ! viral reproduction GO:0016032 92 63 0,000 0,45435789 0,46632002 ! regulation of lipase activity GO:0060191 109 63 0,000 0,45435789 0,46611202 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,45958909 0,47126835 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,45958909 0,47105834 ! hexose catabolic process GO:0019320 82 64 0,000 0,45958909 0,47084851 ! defense response to bacterium GO:0042742 73 65 0,000 0,46477043 0,47594479 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,46477043 0,47573298 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,46990239 0,48077202 ! antigen processing and presentation GO:0019882 96 66 0,000 0,46990239 0,48055825 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,46990239 0,48034467 ! regulation of immune effector process GO:0002697 101 66 0,000 0,46990239 0,48013128 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,47498544 0,48510946 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,48002003 0,49003376 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,48002003 0,48981636 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,48002003 0,48959914 ! inorganic anion transport GO:0015698 93 68 0,000 0,48002003 0,48938212 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,48500663 0,4942469 ! eye development GO:0001654 111 70 0,000 0,48994569 0,49905894 ! muscle cell differentiation GO:0042692 104 71 0,000 0,49483767 0,50381879 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,49483767 0,50359586 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,499683 0,50830204 ! regulation of blood pressure GO:0008217 107 73 0,000 0,50448214 0,51295708 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,50923551 0,5175615 ! digestion GO:0007586 97 74 0,000 0,50923551 0,5173329 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,51394356 0,52188529 ! amine biosynthetic process GO:0009309 97 76 0,000 0,51860671 0,52638809 ! tRNA metabolic process GO:0006399 95 76 0,000 0,51860671 0,5261559 ! response to unfolded protein GO:0006986 99 76 0,000 0,51860671 0,52592391 ! protein ubiquitination GO:0016567 125 77 0,000 0,52322538 0,5303739 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,52322538 0,53014025 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,52322538 0,52990682 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,52780001 0,53430459 ! cellular respiration GO:0045333 107 79 0,000 0,532331 0,53865433 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,532331 0,53841746 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,532331 0,53818079 ! chromatin assembly GO:0031497 102 80 0,000 0,53681877 0,54247943 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,53681877 0,54224119 ! mRNA transport GO:0051028 121 81 0,000 0,54126374 0,54649104 ! regulation of neurological system process GO:0031644 122 81 0,000 0,54126374 0,54625125 ! vitamin metabolic process GO:0006766 103 81 0,000 0,54126374 0,54601167 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,55002686 0,55460841 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,55434581 0,55871839 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,55862356 0,56278326 ! nucleosome organization GO:0034728 114 87 0,000 0,56705699 0,57102937 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,56705699 0,57077946 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,56705699 0,57052978 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,57121344 0,57446039 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,57121344 0,57420932 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,57121344 0,57395846 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,57533023 0,57784259 ! RNA localization GO:0006403 135 91 0,000 0,5834463 0,58573832 ! ATP metabolic process GO:0046034 137 91 0,000 0,5834463 0,58548276 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,59140817 0,5932136 ! electron transport chain GO:0022900 123 94 0,000 0,59533219 0,59688929 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,60306821 0,60438208 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,60688091 0,60793819 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,61439744 0,61519987 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,61810195 0,6186399 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,61810195 0,61837081 ! divalent metal ion transport GO:0070838 171 100 0,000 0,61810195 0,61810195