pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6906-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of cell migration GO:0030335 137 58 9,000 4,783E-12 1,168E-08 ! positive regulation of cell motion GO:0051272 157 65 9,000 1,577E-11 1,926E-08 ! negative regulation of phosphorylation GO:0042326 52 24 6,000 1,496E-10 1,218E-07 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 6,000 2,812E-10 1,717E-07 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of mitochondrial membrane permeability GO:0046902 15 5 3,000 8,952E-09 4,374E-06 ! induction of apoptosis by intracellular signals GO:0008629 95 45 6,000 1,745E-08 7,104E-06 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 4,000 6,729E-08 2,348E-05 ! apoptotic mitochondrial changes GO:0008637 42 20 4,000 1,659E-07 5,066E-05 ! induction of positive chemotaxis GO:0050930 17 9 3,000 2,21E-07 5,998E-05 ! inactivation of MAPK activity GO:0000188 45 22 4,000 2,788E-07 6,811E-05 ! positive regulation of locomotion GO:0040017 44 22 4,000 2,788E-07 6,192E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 45 23 4,000 3,543E-07 7,214E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 6,000 3,63E-07 6,822E-05 ! protein sumoylation GO:0016925 17 10 3,000 3,664E-07 6,394E-05 ! negative regulation of kinase activity GO:0033673 145 70 6,000 4,011E-07 6,532E-05 ! regulation of behavior GO:0050795 48 25 4,000 5,535E-07 8,452E-05 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 3,000 5,728E-07 8,231E-05 ! negative regulation of transferase activity GO:0051348 155 74 6,000 5,889E-07 7,992E-05 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 8,548E-07 1,099E-04 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 37 12 3,000 8,548E-07 1,044E-04 ! regulation of fibroblast proliferation GO:0048145 56 28 4,000 1,008E-06 1,172E-04 ! response to hypoxia GO:0001666 178 81 6,000 1,094E-06 1,215E-04 ! regulation of mRNA stability GO:0043488 32 13 3,000 1,228E-06 1,305E-04 ! response to oxygen levels GO:0070482 183 83 6,000 1,292E-06 1,316E-04 ! negative regulation of growth GO:0045926 168 85 6,000 1,519E-06 1,485E-04 ! regulation of RNA stability GO:0043487 33 14 3,000 1,711E-06 1,607E-04 ! release of cytochrome c from mitochondria GO:0001836 31 14 3,000 1,711E-06 1,548E-04 ! cellular response to extracellular stimulus GO:0031668 52 31 4,000 1,714E-06 1,496E-04 ! negative regulation of survival gene product expression GO:0008634 9 5 2,000 2,754E-06 2,32E-04 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 2,000 2,754E-06 2,243E-04 ! negative regulation of MAP kinase activity GO:0043407 78 34 4,000 2,763E-06 2,177E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 6,000 3,962E-06 3,025E-04 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 3,000 4,005E-06 2,965E-04 ! regulation of protein stability GO:0031647 77 38 4,000 4,879E-06 3,505E-04 ! cell-substrate junction assembly GO:0007044 56 18 3,000 5,123E-06 3,576E-04 ! negative regulation of cell growth GO:0030308 142 67 5,000 5,316E-06 3,608E-04 ! neural nucleus development GO:0048857 19 6 2,000 5,481E-06 3,619E-04 ! negative regulation of cell size GO:0045792 144 69 5,000 6,317E-06 4,061E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 6,317E-06 3,957E-04 ! nucleus organization GO:0006997 73 40 4,000 6,328E-06 3,865E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 3,000 8,028E-06 4,784E-04 ! prostate gland development GO:0030850 14 7 2,000 9,546E-06 5,552E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 9,546E-06 5,423E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 9,546E-06 5,3E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 9,546E-06 5,182E-04 ! cell structure disassembly during apoptosis GO:0006921 32 21 3,000 9,866E-06 5,24E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 1,022E-05 5,314E-04 ! cell-matrix adhesion GO:0007160 181 76 5,000 1,109E-05 5,643E-04 ! apoptotic nuclear changes GO:0030262 34 22 3,000 1,2E-05 5,981E-04 ! positive regulation of intracellular transport GO:0032388 42 22 3,000 1,2E-05 5,862E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 1,277E-05 6,115E-04 ! pigmentation GO:0043473 103 46 4,000 1,277E-05 5,998E-04 ! ER overload response GO:0006983 13 8 2,000 1,52E-05 7,006E-04 ! positive regulation of endothelial cell migration GO:0010595 19 8 2,000 1,52E-05 6,876E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,52E-05 6,751E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,52E-05 6,631E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 1,52E-05 6,514E-04 ! cell-substrate adhesion GO:0031589 189 82 5,000 1,719E-05 7,24E-04 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 3,000 1,725E-05 7,142E-04 ! positive regulation of fibroblast proliferation GO:0048146 48 25 3,000 2,043E-05 8,318E-04 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 3,000 2,043E-05 8,182E-04 ! regulation of glycolysis GO:0006110 20 9 2,000 2,269E-05 8,94E-04 ! middle ear morphogenesis GO:0042474 14 9 2,000 2,269E-05 8,798E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,269E-05 8,661E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 2,402E-05 9,027E-04 ! mitochondrion organization GO:0007005 159 87 5,000 2,412E-05 8,929E-04 ! cartilage development GO:0051216 99 53 4,000 2,575E-05 9,388E-04 ! regulation of endothelial cell proliferation GO:0001936 60 27 3,000 2,805E-05 1,008E-03 ! mitochondrial membrane organization GO:0007006 60 27 3,000 2,805E-05 9,932E-04 ! response to toxin GO:0009636 49 27 3,000 2,805E-05 9,79E-04 ! cellular response to nutrient levels GO:0031669 45 27 3,000 2,805E-05 9,652E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 3,226E-05 1,094E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 3,226E-05 1,079E-03 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 3,226E-05 1,065E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 2,000 3,226E-05 1,051E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 3,226E-05 1,037E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 3,256E-05 1,033E-03 ! regulation of DNA replication GO:0006275 105 56 4,000 3,373E-05 1,056E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 4,000 3,678E-05 1,137E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 4,414E-05 1,348E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 4,414E-05 1,331E-03 GO:0010829|negative regulation of glucose transport, ! regulation of DNA metabolic process GO:0051052 188 97 5,000 4,47E-05 1,332E-03 ! cell junction assembly GO:0034329 85 31 3,000 4,927E-05 1,45E-03 ! regulation of homeostatic process GO:0032844 148 62 4,000 5,534E-05 1,61E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 5,856E-05 1,683E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 2,000 5,856E-05 1,664E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 5,856E-05 1,644E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 2,000 5,856E-05 1,626E-03 ! skeletal system morphogenesis GO:0048705 118 63 4,000 5,98E-05 1,641E-03 ! lung development GO:0030324 165 69 4,000 9,261E-05 2,514E-03 ! urogenital system development GO:0001655 149 69 4,000 9,261E-05 2,486E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 9,596E-05 2,548E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 2,000 9,596E-05 2,521E-03 GO:0060675|ureteric bud morphogenesis, ! response to gamma radiation GO:0010332 30 14 2,000 9,596E-05 2,494E-03 ! cell junction organization GO:0034330 96 37 3,000 1,003E-04 2,579E-03 ! negative regulation of cell activation GO:0050866 69 37 3,000 1,003E-04 2,552E-03 ! cell cycle checkpoint GO:0000075 145 71 4,000 1,062E-04 2,674E-03 ! respiratory tube development GO:0030323 171 72 4,000 1,135E-04 2,829E-03 ! actin filament organization GO:0007015 167 72 4,000 1,135E-04 2,8E-03 ! negative regulation of bone remodeling GO:0046851 34 15 2,000 1,194E-04 2,916E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 1,194E-04 2,887E-03 ! actin cytoskeleton reorganization GO:0031532 38 15 2,000 1,194E-04 2,859E-03 ! G1/S transition checkpoint GO:0031575 37 15 2,000 1,194E-04 2,831E-03 ! mitotic cell cycle checkpoint GO:0007093 76 39 3,000 1,236E-04 2,904E-03 ! carbohydrate homeostasis GO:0033500 59 39 3,000 1,236E-04 2,876E-03 GO:0042593|glucose homeostasis, ! respiratory system development GO:0060541 175 74 4,000 1,293E-04 2,979E-03 ! regulation of glucose metabolic process GO:0010906 28 16 2,000 1,462E-04 3,338E-03 ! axon cargo transport GO:0008088 46 16 2,000 1,462E-04 3,307E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 1,462E-04 3,277E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 2,000 1,462E-04 3,247E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,462E-04 3,218E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of intracellular protein transport GO:0033157 86 42 3,000 1,656E-04 3,613E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 1,767E-04 3,82E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 1,767E-04 3,786E-03 ! negative regulation of blood coagulation GO:0030195 25 17 2,000 1,767E-04 3,753E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 1,767E-04 3,721E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 2,11E-04 4,405E-03 ! defense response to virus GO:0051607 43 18 2,000 2,11E-04 4,368E-03 ! branching morphogenesis of a tube GO:0048754 102 45 3,000 2,171E-04 4,457E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 2,366E-04 4,816E-03 ! positive regulation of protein transport GO:0051222 80 46 3,000 2,366E-04 4,777E-03 ! regulation of endothelial cell migration GO:0010594 45 19 2,000 2,493E-04 4,993E-03 ! cellular pigmentation GO:0033059 37 19 2,000 2,493E-04 4,952E-03 ! mitochondrial transport GO:0006839 94 48 3,000 2,792E-04 5,501E-03 ! cellular component disassembly GO:0022411 89 48 3,000 2,792E-04 5,457E-03 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 2,919E-04 5,66E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 2,000 2,919E-04 5,615E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 2,919E-04 5,572E-03 ! actin filament bundle formation GO:0051017 47 20 2,000 2,919E-04 5,528E-03 ! regulation of glucose import GO:0046324 30 20 2,000 2,919E-04 5,486E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 2,919E-04 5,444E-03 ! negative regulation of coagulation GO:0050819 30 20 2,000 2,919E-04 5,403E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 3,025E-04 5,556E-03 ! tube morphogenesis GO:0035239 194 89 4,000 3,076E-04 5,608E-03 ! activation of caspase activity GO:0006919 95 50 3,000 3,271E-04 5,92E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 3,389E-04 6,088E-03 ! gland development GO:0048732 220 91 4,000 3,41E-04 6,081E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 3,771E-04 6,675E-03 ! morphogenesis of a branching structure GO:0001763 116 52 3,000 3,806E-04 6,689E-03 ! microtubule-based transport GO:0010970 59 22 2,000 3,906E-04 6,815E-03 ! cellular response to starvation GO:0009267 37 22 2,000 3,906E-04 6,767E-03 ! ureteric bud development GO:0001657 50 22 2,000 3,906E-04 6,719E-03 ! cell aging GO:0007569 48 22 2,000 3,906E-04 6,672E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 3,906E-04 6,626E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 4,096E-04 6,901E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of multicellular organismal process GO:0051241 174 95 4,000 4,159E-04 6,96E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 4,223E-04 7,019E-03 GO:0045844|positive regulation of striated muscle development, ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 4,223E-04 6,972E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,223E-04 6,925E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 4,223E-04 6,879E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 4,223E-04 6,833E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 4,223E-04 6,788E-03 ! microvillus organization GO:0032528 8 5 1,000 4,223E-04 6,744E-03 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 1,000 4,223E-04 6,7E-03 ! mRNA transcription GO:0009299 10 5 1,000 4,223E-04 6,657E-03 ! positive regulation of filopodium assembly GO:0051491 16 5 1,000 4,223E-04 6,614E-03 GO:0051489|regulation of filopodium assembly, ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 4,223E-04 6,572E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 4,223E-04 6,53E-03 ! cellular glucose homeostasis GO:0001678 6 5 1,000 4,223E-04 6,489E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 4,223E-04 6,449E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 4,223E-04 6,409E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 4,223E-04 6,369E-03 ! B cell homeostasis GO:0001782 13 5 1,000 4,223E-04 6,33E-03 ! cellular response to nutrient GO:0031670 8 5 1,000 4,223E-04 6,291E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 4,223E-04 6,253E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 4,223E-04 6,216E-03 ! stem cell division GO:0017145 11 5 1,000 4,223E-04 6,178E-03 GO:0048103|somatic stem cell division, ! regulation of angiogenesis GO:0045765 125 54 3,000 4,401E-04 6,4E-03 ! epithelial tube morphogenesis GO:0060562 114 54 3,000 4,401E-04 6,362E-03 ! positive regulation of DNA replication GO:0045740 44 23 2,000 4,47E-04 6,423E-03 ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 4,47E-04 6,386E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 4,47E-04 6,348E-03 ! regulation of protein localization GO:0032880 188 97 4,000 4,578E-04 6,464E-03 ! response to UV GO:0009411 120 55 3,000 4,722E-04 6,63E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 4,722E-04 6,592E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 5,084E-04 7,056E-03 ! positive regulation of caspase activity GO:0043280 108 57 3,000 5,413E-04 7,471E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 3,000 5,413E-04 7,429E-03 ! aging GO:0007568 112 58 3,000 5,785E-04 7,895E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 6,308E-04 8,561E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 6,308E-04 8,514E-03 ! toxin metabolic process GO:0009404 11 6 1,000 6,308E-04 8,467E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 6,308E-04 8,421E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 1,000 6,308E-04 8,375E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! neuron apoptosis GO:0051402 15 6 1,000 6,308E-04 8,33E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 6,308E-04 8,285E-03 ! negative regulation of platelet activation GO:0010544 9 6 1,000 6,308E-04 8,241E-03 GO:0010543|regulation of platelet activation, ! early endosome to late endosome transport GO:0045022 16 6 1,000 6,308E-04 8,197E-03 ! purine base biosynthetic process GO:0009113 17 6 1,000 6,308E-04 8,153E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 6,308E-04 8,11E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 6,308E-04 8,068E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 6,308E-04 8,026E-03 ! triglyceride catabolic process GO:0019433 10 6 1,000 6,308E-04 7,984E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 6,308E-04 7,943E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 6,467E-04 8,103E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 6,467E-04 8,061E-03 ! regulation of blood coagulation GO:0030193 46 26 2,000 6,467E-04 8,02E-03 ! DNA catabolic process GO:0006308 94 60 3,000 6,581E-04 8,12E-03 ! response to starvation GO:0042594 47 27 2,000 7,241E-04 8,889E-03 ! cellular response to oxidative stress GO:0034599 43 27 2,000 7,241E-04 8,845E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 7,241E-04 8,801E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 8,071E-04 9,761E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 8,071E-04 9,713E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 8,401E-04 0,01006085 ! regulation of helicase activity GO:0051095 16 7 1,000 8,793E-04 0,01047835 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 8,793E-04 0,01042749 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 8,793E-04 0,01037711 ! mRNA stabilization GO:0048255 18 7 1,000 8,793E-04 0,01032722 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 8,793E-04 0,01027781 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 8,793E-04 0,01022887 ! glycerol ether catabolic process GO:0044269 12 7 1,000 8,793E-04 0,01018039 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 1,000 8,793E-04 0,01013237 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 8,793E-04 0,0100848 ! fibrinolysis GO:0042730 11 7 1,000 8,793E-04 0,01003768 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 8,793E-04 9,991E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 8,793E-04 9,945E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 8,793E-04 9,899E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 8,793E-04 9,853E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 8,958E-04 9,993E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 8,958E-04 9,948E-03 ! ear development GO:0043583 114 66 3,000 9,433E-04 0,01042735 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 9,906E-04 0,01090101 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 9,906E-04 0,01085212 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 2,000 9,906E-04 0,01080367 ! regulation of coagulation GO:0050818 52 30 2,000 9,906E-04 0,01075566 ! iron ion homeostasis GO:0055072 60 31 2,000 1,091E-03 0,0117983 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 1,091E-03 0,01174632 ! succinate metabolic process GO:0006105 17 8 1,000 1,167E-03 0,01250748 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,167E-03 0,01245287 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,167E-03 0,01239872 ! glycerolipid catabolic process GO:0046503 14 8 1,000 1,167E-03 0,01234505 ! hemoglobin metabolic process GO:0020027 14 8 1,000 1,167E-03 0,01229184 ! pigment granule organization GO:0048753 17 8 1,000 1,167E-03 0,01223908 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,167E-03 0,01218678 ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,167E-03 0,01213492 ! melanin metabolic process GO:0006582 17 8 1,000 1,167E-03 0,0120835 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,167E-03 0,01203252 ! synaptic transmission, glutamatergic GO:0035249 24 8 1,000 1,167E-03 0,01198196 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,167E-03 0,01193183 ! response to UV-B GO:0010224 17 8 1,000 1,167E-03 0,01188211 ! gas homeostasis GO:0033483 14 8 1,000 1,167E-03 0,01183281 ! response to tumor cell GO:0002347 16 8 1,000 1,167E-03 0,01178391 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 1,167E-03 0,01173542 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 1,000 1,167E-03 0,01168732 ! spindle organization GO:0007051 50 32 2,000 1,199E-03 0,0119514 ! metanephros development GO:0001656 81 32 2,000 1,199E-03 0,01190282 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 1,199E-03 0,01185463 ! hindbrain development GO:0030902 65 32 2,000 1,199E-03 0,01180683 ! positive regulation of gene-specific transcription GO:0043193 70 33 2,000 1,312E-03 0,01287313 ! response to ionizing radiation GO:0010212 74 33 2,000 1,312E-03 0,01282164 ! leukocyte chemotaxis GO:0030595 55 33 2,000 1,312E-03 0,01277056 GO:0060326|cell chemotaxis, ! regulation of caspase activity GO:0043281 136 74 3,000 1,446E-03 0,0140157 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 3,000 1,446E-03 0,0139603 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,494E-03 0,01437261 ! neutral lipid catabolic process GO:0046461 14 9 1,000 1,494E-03 0,01431625 ! microtubule bundle formation GO:0001578 22 9 1,000 1,494E-03 0,01426032 ! T cell selection GO:0045058 27 9 1,000 1,494E-03 0,01420484 ! receptor clustering GO:0043113 20 9 1,000 1,494E-03 0,01414978 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,494E-03 0,01409515 ! purine base metabolic process GO:0006144 25 9 1,000 1,494E-03 0,01404093 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,494E-03 0,01398714 ! regulation of transcription factor activity GO:0051090 137 75 3,000 1,519E-03 0,01416786 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 3,000 1,519E-03 0,01411399 ! DNA damage checkpoint GO:0000077 78 35 2,000 1,559E-03 0,01442543 ! regulation of striated muscle tissue development GO:0016202 81 35 2,000 1,559E-03 0,014371 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 1,675E-03 0,01537974 ! regulation of catabolic process GO:0009894 173 77 3,000 1,675E-03 0,01532214 ! regulation of muscle development GO:0048634 82 36 2,000 1,692E-03 0,01542746 ! negative regulation of DNA binding GO:0043392 67 36 2,000 1,692E-03 0,01537011 ! tissue remodeling GO:0048771 78 37 2,000 1,833E-03 0,01658429 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 3,000 1,84E-03 0,01659083 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 1,000 1,86E-03 0,01670443 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,86E-03 0,01664324 ! lung alveolus development GO:0048286 26 10 1,000 1,86E-03 0,0165825 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 1,86E-03 0,0165222 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,86E-03 0,01646233 GO:0006600|creatine metabolic process, ! B cell proliferation GO:0042100 19 10 1,000 1,86E-03 0,0164029 ! nucleobase biosynthetic process GO:0046112 26 10 1,000 1,86E-03 0,0163439 ! epithelial cell development GO:0002064 21 10 1,000 1,86E-03 0,01628532 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 1,86E-03 0,01622716 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,86E-03 0,01616941 ! motor axon guidance GO:0008045 22 10 1,000 1,86E-03 0,01611207 ! regulation of bone resorption GO:0045124 25 10 1,000 1,86E-03 0,01605514 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,86E-03 0,01599861 ! response to nicotine GO:0035094 20 10 1,000 1,86E-03 0,01594247 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 1,98E-03 0,01691685 ! embryonic skeletal system morphogenesis GO:0048704 68 38 2,000 1,98E-03 0,0168579 ! DNA integrity checkpoint GO:0031570 82 38 2,000 1,98E-03 0,01679937 ! pigment metabolic process GO:0042440 87 38 2,000 1,98E-03 0,01674124 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 2,017E-03 0,01699378 ! regulation of peptidase activity GO:0052547 150 82 3,000 2,11E-03 0,01771352 ! negative regulation of binding GO:0051100 71 39 2,000 2,135E-03 0,01786383 ! response to drug GO:0042493 149 83 3,000 2,206E-03 0,0183896 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 2,206E-03 0,01832705 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of muscle development GO:0048635 27 11 1,000 2,263E-03 0,0187435 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,263E-03 0,01868018 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 2,263E-03 0,01861728 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,263E-03 0,01855481 ! blood vessel remodeling GO:0001974 30 11 1,000 2,263E-03 0,01849275 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 2,263E-03 0,01843111 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,263E-03 0,01836988 ! regulation of intracellular pH GO:0051453 21 11 1,000 2,263E-03 0,01830905 ! substrate-bound cell migration GO:0006929 14 11 1,000 2,263E-03 0,01824862 ! behavioral fear response GO:0001662 27 11 1,000 2,263E-03 0,0181886 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 2,263E-03 0,01812896 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 2,263E-03 0,01806972 ! alpha-beta T cell activation GO:0046631 26 11 1,000 2,263E-03 0,01801086 ! nitric oxide metabolic process GO:0046209 17 11 1,000 2,263E-03 0,01795238 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 1,000 2,263E-03 0,01789428 GO:0006305|DNA alkylation, ! apical protein localization GO:0045176 18 11 1,000 2,263E-03 0,01783656 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 2,263E-03 0,01777921 ! thymus development GO:0048538 29 11 1,000 2,263E-03 0,01772222 ! oocyte development GO:0048599 20 11 1,000 2,263E-03 0,0176656 ! response to nutrient GO:0007584 135 84 3,000 2,304E-03 0,01792632 ! regulation of ligase activity GO:0051340 147 84 3,000 2,304E-03 0,01786941 ! negative regulation of transport GO:0051051 164 85 3,000 2,406E-03 0,01859772 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 2,467E-03 0,01900985 ! mesenchymal cell development GO:0014031 94 41 2,000 2,467E-03 0,01895007 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of protein transport GO:0051223 165 87 3,000 2,618E-03 0,02004784 GO:0070201|regulation of establishment of protein localization, ! ear morphogenesis GO:0042471 64 42 2,000 2,644E-03 0,02018294 ! T cell differentiation GO:0030217 93 42 2,000 2,644E-03 0,02012007 ! regulation of T cell differentiation GO:0045580 78 42 2,000 2,644E-03 0,02005758 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,704E-03 0,02045383 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 2,704E-03 0,0203907 ! regulation of cell projection assembly GO:0060491 33 12 1,000 2,704E-03 0,02032796 ! oligodendrocyte differentiation GO:0048709 17 12 1,000 2,704E-03 0,0202656 ! cranial nerve development GO:0021545 23 12 1,000 2,704E-03 0,02020363 ! histone acetylation GO:0016573 27 12 1,000 2,704E-03 0,02014203 ! mRNA polyadenylation GO:0006378 24 12 1,000 2,704E-03 0,02008081 ! autonomic nervous system development GO:0048483 24 12 1,000 2,704E-03 0,02001996 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 2,704E-03 0,01995947 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,704E-03 0,01989935 ! T cell homeostasis GO:0043029 28 12 1,000 2,704E-03 0,0198396 ! regulation of leukocyte migration GO:0002685 29 12 1,000 2,704E-03 0,0197802 ! oocyte differentiation GO:0009994 21 12 1,000 2,704E-03 0,01972115 ! embryonic placenta development GO:0001892 21 12 1,000 2,704E-03 0,01966246 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 2,000 2,828E-03 0,02050339 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 2,828E-03 0,02044273 ! regulation of T cell proliferation GO:0042129 80 43 2,000 2,828E-03 0,02038243 ! regulation of DNA binding GO:0051101 167 89 3,000 2,842E-03 0,02042402 ! positive regulation of protein modification process GO:0031401 156 90 3,000 2,96E-03 0,02120335 ! response to reactive oxygen species GO:0000302 75 44 2,000 3,021E-03 0,02157802 ! regulation of chemokine production GO:0032642 18 13 1,000 3,182E-03 0,0226651 ! cartilage condensation GO:0001502 22 13 1,000 3,182E-03 0,02259922 ! negative regulation of lipid metabolic process GO:0045833 20 13 1,000 3,182E-03 0,02253371 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,182E-03 0,02246859 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 1,000 3,182E-03 0,02240383 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! response to X-ray GO:0010165 28 13 1,000 3,182E-03 0,02233946 ! asymmetric protein localization GO:0008105 24 13 1,000 3,182E-03 0,02227545 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 3,182E-03 0,0222118 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 3,182E-03 0,02214852 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,182E-03 0,0220856 ! gland morphogenesis GO:0022612 31 13 1,000 3,182E-03 0,02202303 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 3,182E-03 0,02196082 ! spleen development GO:0048536 24 13 1,000 3,182E-03 0,02189896 ! digestive tract morphogenesis GO:0048546 31 13 1,000 3,182E-03 0,02183745 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 1,000 3,182E-03 0,02177628 ! regulation of fatty acid oxidation GO:0046320 34 13 1,000 3,182E-03 0,02171545 ! mRNA 3'-end processing GO:0031124 25 13 1,000 3,182E-03 0,02165496 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 3,182E-03 0,02159481 ! regulation of cell adhesion GO:0030155 241 92 3,000 3,204E-03 0,0216805 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 3,221E-03 0,02173733 ! B cell differentiation GO:0030183 124 45 2,000 3,221E-03 0,02167745 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 3,429E-03 0,02301534 ! leukocyte migration GO:0050900 75 46 2,000 3,429E-03 0,02295229 ! negative regulation of cell migration GO:0030336 122 46 2,000 3,429E-03 0,02288958 ! cell growth GO:0016049 90 46 2,000 3,429E-03 0,02282721 ! regulation of membrane potential GO:0042391 179 94 3,000 3,461E-03 0,02297733 ! hair follicle morphogenesis GO:0031069 27 14 1,000 3,697E-03 0,02447357 ! RNA polyadenylation GO:0043631 32 14 1,000 3,697E-03 0,02440743 ! fear response GO:0042596 34 14 1,000 3,697E-03 0,02434164 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 3,697E-03 0,0242762 ! regulation of cellular pH GO:0030641 27 14 1,000 3,697E-03 0,02421112 ! male genitalia development GO:0030539 26 14 1,000 3,697E-03 0,02414638 ! sex differentiation GO:0007548 171 96 3,000 3,732E-03 0,0243151 ! positive regulation of defense response GO:0031349 88 48 2,000 3,87E-03 0,02514411 ! male sex differentiation GO:0046661 93 48 2,000 3,87E-03 0,02507741 ! regulation of inflammatory response GO:0050727 84 48 2,000 3,87E-03 0,02501107 ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 4,103E-03 0,02644477 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 4,247E-03 0,02730323 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 4,247E-03 0,02723157 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 4,247E-03 0,02716029 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 4,247E-03 0,02708937 ! synaptic transmission, cholinergic GO:0007271 24 15 1,000 4,247E-03 0,02701883 ! muscle maintenance GO:0046716 26 15 1,000 4,247E-03 0,02694865 ! lymphocyte homeostasis GO:0002260 33 15 1,000 4,247E-03 0,02687883 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 4,247E-03 0,02680938 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 1,000 4,247E-03 0,02674028 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 4,344E-03 0,0272784 ! negative regulation of immune system process GO:0002683 101 51 2,000 4,593E-03 0,02877072 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 1,000 4,833E-03 0,03019534 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 4,833E-03 0,03011831 ! positive regulation of growth GO:0045927 96 53 2,000 5,117E-03 0,03181076 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 5,117E-03 0,03173002 ! embryonic skeletal system development GO:0048706 101 54 2,000 5,392E-03 0,03335133 ! regulation of muscle contraction GO:0006937 94 54 2,000 5,392E-03 0,03326711 ! regulation of cell shape GO:0008360 142 54 2,000 5,392E-03 0,03318331 ! metencephalon development GO:0022037 32 17 1,000 5,454E-03 0,03347491 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 5,454E-03 0,03339101 ! signal complex assembly GO:0007172 47 17 1,000 5,454E-03 0,03330753 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 5,454E-03 0,03322447 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 1,000 5,454E-03 0,03314182 ! nucleobase metabolic process GO:0009112 43 17 1,000 5,454E-03 0,03305959 ! genitalia development GO:0048806 32 17 1,000 5,454E-03 0,03297776 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 5,454E-03 0,03289633 ! RNA 3'-end processing GO:0031123 37 17 1,000 5,454E-03 0,0328153 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 5,676E-03 0,03407187 ! heart looping GO:0001947 34 18 1,000 6,109E-03 0,03657833 ! regulation of viral genome replication GO:0045069 30 18 1,000 6,109E-03 0,0364889 ! epidermis morphogenesis GO:0048730 43 18 1,000 6,109E-03 0,0363999 ! glutamine metabolic process GO:0006541 29 18 1,000 6,109E-03 0,03631134 ! response to retinoic acid GO:0032526 31 18 1,000 6,109E-03 0,0362232 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 1,000 6,109E-03 0,0361355 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 6,109E-03 0,03604821 ! neural crest cell migration GO:0001755 41 18 1,000 6,109E-03 0,03596135 ! nerve development GO:0021675 34 18 1,000 6,109E-03 0,0358749 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 6,109E-03 0,03578887 ! regulation of bone remodeling GO:0046850 143 57 2,000 6,271E-03 0,03664805 ! regulation of tissue remodeling GO:0034103 146 58 2,000 6,581E-03 0,03837083 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 6,798E-03 0,03954299 ! regulation of lipid biosynthetic process GO:0046890 28 19 1,000 6,798E-03 0,03944907 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 6,798E-03 0,03935559 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 6,798E-03 0,03926255 ! pigmentation during development GO:0048066 42 19 1,000 6,798E-03 0,03916995 ! response to vitamin A GO:0033189 32 19 1,000 6,798E-03 0,03907778 ! neuromuscular junction development GO:0007528 43 19 1,000 6,798E-03 0,03898605 ! kidney development GO:0001822 133 60 2,000 7,229E-03 0,04135951 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 7,521E-03 0,04293027 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 7,521E-03 0,0428302 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 7,521E-03 0,0427306 ! protein amino acid acetylation GO:0006473 41 20 1,000 7,521E-03 0,04263145 ! response to vitamin GO:0033273 36 20 1,000 7,521E-03 0,04253277 ! forelimb morphogenesis GO:0035136 35 20 1,000 7,521E-03 0,04243454 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 7,521E-03 0,04233677 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 7,521E-03 0,04223944 ! regulation of heart contraction GO:0008016 123 61 2,000 7,567E-03 0,04239781 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 7,567E-03 0,04230079 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 7,914E-03 0,04413886 ! lipid phosphorylation GO:0046834 43 21 1,000 8,277E-03 0,04606178 ! ovarian follicle development GO:0001541 39 21 1,000 8,277E-03 0,04595709 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 8,277E-03 0,04585288 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 8,635E-03 0,04772715 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 2,000 9,01E-03 0,04968592 ! hindlimb morphogenesis GO:0035137 47 22 1,000 9,066E-03 0,04988248 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 9,066E-03 0,04977038 ! renal system process GO:0003014 42 22 1,000 9,066E-03 0,04965879 ! cholesterol biosynthetic process GO:0006695 39 22 1,000 9,066E-03 0,0495477 ! G1 phase GO:0051318 44 22 1,000 9,066E-03 0,0494371 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 9,066E-03 0,04932699 ! positive regulation of B cell activation GO:0050871 42 22 1,000 9,066E-03 0,04921738 ! response to cytokine stimulus GO:0034097 69 22 1,000 9,066E-03 0,04910825 ! gut development GO:0048565 44 22 1,000 9,066E-03 0,0489996 ! protein stabilization GO:0050821 41 22 1,000 9,066E-03 0,04889144 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 9,394E-03 0,05054904 ! fatty acid biosynthetic process GO:0006633 139 67 2,000 9,787E-03 0,05255102 ! secondary metabolic process GO:0019748 125 67 2,000 9,787E-03 0,05243578 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 9,887E-03 0,05285151 ! regeneration GO:0031099 42 23 1,000 9,887E-03 0,05273612 ! response to ethanol GO:0045471 47 23 1,000 9,887E-03 0,05262122 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 9,887E-03 0,05250683 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 9,887E-03 0,05239293 ! DNA modification GO:0006304 36 23 1,000 9,887E-03 0,05227953 ! nerve-nerve synaptic transmission GO:0007270 59 23 1,000 9,887E-03 0,05216661 ! extracellular matrix organization GO:0030198 146 68 2,000 0,01019047 0,05365372 ! adaptive immune response GO:0002250 126 68 2,000 0,01019047 0,05353833 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 2,000 0,01019047 0,05342344 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 2,000 0,01060303 0,05546723 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 0,01073925 0,05605979 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01073925 0,05594026 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 0,01073925 0,05582124 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 0,01073925 0,05570272 ! regulation of viral reproduction GO:0050792 41 24 1,000 0,01073925 0,05558471 ! oogenesis GO:0048477 44 24 1,000 0,01073925 0,05546719 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 0,01073925 0,05535017 ! platelet activation GO:0030168 41 24 1,000 0,01073925 0,05523364 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 1,000 0,01073925 0,05511761 ! negative regulation of catabolic process GO:0009895 52 24 1,000 0,01073925 0,05500206 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 0,01073925 0,05488699 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 0,0116231 0,05928026 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 0,0116231 0,05915676 ! vasculogenesis GO:0001570 49 25 1,000 0,0116231 0,05903377 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 0,0116231 0,0589113 ! negative regulation of DNA replication GO:0008156 45 25 1,000 0,0116231 0,05878933 ! receptor metabolic process GO:0043112 53 25 1,000 0,0116231 0,05866786 ! lymphocyte proliferation GO:0046651 55 25 1,000 0,0116231 0,0585469 ! leukocyte homeostasis GO:0001776 50 25 1,000 0,0116231 0,05842643 ! protein tetramerization GO:0051262 57 25 1,000 0,0116231 0,05830646 ! B cell activation GO:0042113 179 72 2,000 0,0118982 0,05956414 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 2,000 0,0118982 0,05944234 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 2,000 0,0118982 0,05932103 ! humoral immune response GO:0006959 115 73 2,000 0,01234921 0,06144425 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,0125378 0,06225579 ! myelination GO:0042552 50 26 1,000 0,0125378 0,06212951 ! molting cycle process GO:0022404 52 26 1,000 0,0125378 0,06200374 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,0125378 0,06187848 ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 0,0125378 0,06175373 ! neural crest cell development GO:0014032 59 26 1,000 0,0125378 0,06162947 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 1,000 0,0125378 0,06150572 GO:0050768|negative regulation of neurogenesis, ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 1,000 0,0125378 0,06138246 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! neural tube closure GO:0001843 58 26 1,000 0,0125378 0,0612597 GO:0060606|tube closure, ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,01328036 0,06475832 ! positive regulation of cell projection organization GO:0031346 66 27 1,000 0,0134829 0,06561499 ! tube lumen formation GO:0035148 59 27 1,000 0,0134829 0,06548454 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,0134829 0,06535461 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 0,0134829 0,06522519 ! regulation of chromosome organization GO:0033044 49 27 1,000 0,0134829 0,06509629 ! leukocyte proliferation GO:0070661 59 27 1,000 0,0134829 0,06496789 GO:0032943|mononuclear cell proliferation, ! lymphocyte differentiation GO:0030098 193 76 2,000 0,01376055 0,06617524 ! positive regulation of ligase activity GO:0051351 130 77 2,000 0,01425052 0,06839691 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01445796 0,06925648 ! dendrite development GO:0016358 67 28 1,000 0,01445796 0,06912095 ! base-excision repair GO:0006284 41 28 1,000 0,01445796 0,06898595 ! glutathione metabolic process GO:0006749 42 28 1,000 0,01445796 0,06885147 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01546256 0,07349231 ! primary neural tube formation GO:0014020 61 29 1,000 0,01546256 0,0733496 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01546256 0,07320745 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01546256 0,07306585 ! somitogenesis GO:0001756 52 29 1,000 0,01546256 0,0729248 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01546256 0,07278429 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01577934 0,07413257 ! complement activation, classical pathway GO:0006958 51 30 1,000 0,01649628 0,07735202 ! sterol biosynthetic process GO:0016126 56 30 1,000 0,01649628 0,07720384 ! tissue homeostasis GO:0001894 50 30 1,000 0,01649628 0,07705622 GO:0048871|multicellular organismal homeostasis, ! meiotic cell cycle GO:0051321 144 82 2,000 0,01684785 0,07854826 ! ovulation cycle process GO:0022602 55 31 1,000 0,01755868 0,08170638 ! male gonad development GO:0008584 56 31 1,000 0,01755868 0,08155105 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01755868 0,0813963 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01755868 0,08124214 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 1,000 0,01755868 0,08108857 ! T cell activation GO:0042110 189 84 2,000 0,01795593 0,08276666 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,01852484 0,08522822 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 0,01852484 0,08506802 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,01864935 0,08547912 ! collagen metabolic process GO:0032963 49 32 1,000 0,01864935 0,08531904 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 1,000 0,01864935 0,08515957 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01864935 0,08500069 ! mesoderm formation GO:0001707 73 32 1,000 0,01864935 0,0848424 ! ovulation cycle GO:0042698 57 32 1,000 0,01864935 0,0846847 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01864935 0,08452759 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01864935 0,08437105 ! regulation of pH GO:0006885 56 33 1,000 0,01976789 0,08926608 ! pigment biosynthetic process GO:0046148 73 33 1,000 0,01976789 0,08910138 ! triglyceride metabolic process GO:0006641 46 33 1,000 0,01976789 0,08893729 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,01976789 0,0887738 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,02091387 0,09374787 ! glial cell differentiation GO:0010001 67 34 1,000 0,02091387 0,09357617 ! post-embryonic development GO:0009791 76 34 1,000 0,02091387 0,09340509 ! inner ear morphogenesis GO:0042472 51 34 1,000 0,02091387 0,09323465 ! formation of primary germ layer GO:0001704 76 34 1,000 0,02091387 0,09306482 ! cell fate specification GO:0001708 56 34 1,000 0,02091387 0,09289561 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,0220869 0,09792795 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 0,0220869 0,09775054 ! mesoderm morphogenesis GO:0048332 80 35 1,000 0,0220869 0,09757378 ! placenta development GO:0001890 53 35 1,000 0,0220869 0,09739765 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,02328658 0,1025029 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02328658 0,10231854 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,02328658 0,10213484 ! embryonic organ development GO:0048568 67 36 1,000 0,02328658 0,10195181 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 0,02343412 0,10241423 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,0245125 0,10693579 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,0245125 0,10674517 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,0245125 0,10655524 ! xenobiotic metabolic process GO:0006805 55 37 1,000 0,0245125 0,10636597 ! odontogenesis GO:0042476 74 37 1,000 0,0245125 0,10617738 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,0245125 0,10598946 ! female gonad development GO:0008585 71 37 1,000 0,0245125 0,1058022 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,0245125 0,1056156 ! regulation of defense response GO:0031347 171 95 2,000 0,02476097 0,10649832 ! regulation of T cell activation GO:0050863 175 96 2,000 0,02543931 0,10922361 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,02576428 0,11042481 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,02576428 0,11023143 GO:0006639|acylglycerol metabolic process, ! glycogen metabolic process GO:0005977 63 38 1,000 0,02576428 0,11003871 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 0,02576428 0,10984667 ! neural tube formation GO:0001841 79 38 1,000 0,02576428 0,1096553 ! transcription initiation GO:0006352 171 97 2,000 0,02612759 0,11100818 ! leukocyte differentiation GO:0002521 232 98 2,000 0,0268258 0,11377679 ! nucleotide catabolic process GO:0009166 70 39 1,000 0,02704153 0,114493 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02704153 0,11429492 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 0,02704153 0,11409752 GO:0006073|cellular glucan metabolic process, ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,02825197 0,11899926 GO:0060538|skeletal muscle organ development, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 1,000 0,02834386 0,11918083 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 1,000 0,02834386 0,11897605 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,02834386 0,11877197 GO:0046660|female sex differentiation, ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02834386 0,1185686 ! glycerol ether metabolic process GO:0006662 57 40 1,000 0,02834386 0,11836592 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,02834386 0,11816393 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,0296709 0,12348553 ! gliogenesis GO:0042063 91 41 1,000 0,0296709 0,12327552 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,0296709 0,12306622 ! maintenance of protein location GO:0045185 95 41 1,000 0,0296709 0,12285764 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,0296709 0,12264976 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,03102226 0,12801922 ! organic ether metabolic process GO:0018904 59 42 1,000 0,03102226 0,12780334 ! ribonucleoside metabolic process GO:0009119 64 42 1,000 0,03102226 0,12758818 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,03102226 0,12737375 ! response to xenobiotic stimulus GO:0009410 63 42 1,000 0,03102226 0,12716003 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,03235117 0,1323851 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03235117 0,13216372 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03235117 0,13194308 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03235117 0,13172317 ! neuron fate determination GO:0048664 7 5 0,000 0,03235117 0,131504 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03235117 0,13128555 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03235117 0,13106783 ! polyol transport GO:0015791 12 5 0,000 0,03235117 0,13085083 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03235117 0,13063455 ! response to superoxide GO:0000303 10 5 0,000 0,03235117 0,13041898 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03235117 0,13020412 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,03235117 0,12998997 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03235117 0,12977652 ! female meiosis GO:0007143 10 5 0,000 0,03235117 0,12956378 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,03235117 0,12935172 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03235117 0,12914036 ! hypothalamus development GO:0021854 9 5 0,000 0,03235117 0,12892969 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03235117 0,12871971 ! cobalt ion transport GO:0006824 11 5 0,000 0,03235117 0,12851041 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03235117 0,12830179 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03235117 0,12809385 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03235117 0,12788657 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03235117 0,12767997 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03235117 0,12747404 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03235117 0,12726876 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03235117 0,12706415 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03235117 0,1268602 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03235117 0,1266569 ! transposition GO:0032196 9 5 0,000 0,03235117 0,12645424 ! negative chemotaxis GO:0050919 16 5 0,000 0,03235117 0,12625224 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03235117 0,12605088 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03235117 0,12585016 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03235117 0,12565008 ! behavioral response to pain GO:0048266 10 5 0,000 0,03235117 0,12545064 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03235117 0,12525183 ! Notch receptor processing GO:0007220 11 5 0,000 0,03235117 0,12505364 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03235117 0,12485609 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03235117 0,12465915 ! micturition GO:0060073 9 5 0,000 0,03235117 0,12446284 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03235117 0,12426714 ! copulation GO:0007620 9 5 0,000 0,03235117 0,12407206 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03235117 0,12387759 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03235117 0,12368373 ! bioluminescence GO:0008218 9 5 0,000 0,03235117 0,12349047 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03235117 0,12329782 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03235117 0,12310577 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03235117 0,12291431 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03235117 0,12272345 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03235117 0,12253318 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03235117 0,1223435 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03235117 0,12215441 ! grooming behavior GO:0007625 6 5 0,000 0,03235117 0,1219659 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03235117 0,12177797 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03235117 0,12159062 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03235117 0,12140384 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03235117 0,12121764 ! response to protozoan GO:0001562 13 5 0,000 0,03235117 0,12103201 ! lymph vessel development GO:0001945 10 5 0,000 0,03235117 0,12084695 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03235117 0,12066245 ! endochondral ossification GO:0001958 17 5 0,000 0,03235117 0,12047851 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03235117 0,12029513 ! single strand break repair GO:0000012 8 5 0,000 0,03235117 0,12011231 ! parathyroid gland development GO:0060017 14 5 0,000 0,03235117 0,11993005 ! anagen GO:0042640 7 5 0,000 0,03235117 0,11974834 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03235117 0,11956718 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03235117 0,11938656 ! cytokine secretion GO:0050663 15 5 0,000 0,03235117 0,11920649 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03235117 0,11902696 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03235117 0,11884797 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03235117 0,11866952 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03235117 0,11849161 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03235117 0,11831423 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03235117 0,11813737 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03235117 0,11796105 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03235117 0,11778525 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03235117 0,11760997 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03235117 0,11743522 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03235117 0,11726098 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03235117 0,11708726 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03235117 0,11691406 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03235117 0,11674136 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03235117 0,11656918 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03235117 0,1163975 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03235117 0,11622633 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03235117 0,11605566 ! polyol catabolic process GO:0046174 9 5 0,000 0,03235117 0,11588549 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03235117 0,11571582 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03235117 0,11554664 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03235117 0,11537796 ! muscle cell migration GO:0014812 8 5 0,000 0,03235117 0,11520977 ! mitochondrial fission GO:0000266 8 5 0,000 0,03235117 0,11504207 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03235117 0,11487486 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03235117 0,11470813 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03235117 0,11454189 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03235117 0,11437613 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03235117 0,11421084 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03235117 0,11404604 ! monocyte activation GO:0042117 10 5 0,000 0,03235117 0,1138817 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03235117 0,11371785 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03235117 0,11355446 ! response to food GO:0032094 6 5 0,000 0,03235117 0,11339154 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03235117 0,11322909 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03235117 0,1130671 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03235117 0,11290558 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,03235117 0,11274451 ! forebrain neuron development GO:0021884 13 5 0,000 0,03235117 0,11258391 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03235117 0,11242376 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,03235117 0,11226407 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03235117 0,11210483 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03235117 0,11194604 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03235117 0,1117877 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03235117 0,11162981 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03235117 0,11147236 ! lipid glycosylation GO:0030259 7 5 0,000 0,03235117 0,11131536 ! nucleobase transport GO:0015851 6 5 0,000 0,03235117 0,11115879 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03235117 0,11100267 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03235117 0,11084699 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,03235117 0,11069174 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03235117 0,11053693 ! basic amino acid transport GO:0015802 12 5 0,000 0,03235117 0,11038255 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03235117 0,1102286 ! actin nucleation GO:0045010 11 5 0,000 0,03235117 0,11007507 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03235117 0,10992198 ! depurination GO:0045007 5 5 0,000 0,03235117 0,10976931 ! depyrimidination GO:0045008 10 5 0,000 0,03235117 0,10961706 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03235117 0,10946524 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03235117 0,10931384 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03235117 0,10916285 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,03235117 0,10901228 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03235117 0,10886213 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03235117 0,10871238 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03235117 0,10856305 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03235117 0,10841413 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03235117 0,10826562 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03235117 0,10811751 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03235117 0,10796981 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03235117 0,10782251 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03235117 0,10767562 ! response to arsenic GO:0046685 11 5 0,000 0,03235117 0,10752912 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,03235117 0,10738302 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03235117 0,10723732 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03235117 0,10709201 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03235117 0,10694709 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03235117 0,10680257 ! response to mercury ion GO:0046689 8 5 0,000 0,03235117 0,10665844 ! response to cadmium ion GO:0046686 7 5 0,000 0,03235117 0,10651469 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03235117 0,10637134 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03235117 0,10622836 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03235117 0,10608578 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03235117 0,10594357 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03235117 0,10580174 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03235117 0,1056603 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03235117 0,10551923 ! decidualization GO:0046697 11 5 0,000 0,03235117 0,10537854 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03235117 0,10523822 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03235117 0,10509827 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03235117 0,1049587 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03235117 0,1048195 ! embryonic cleavage GO:0040016 6 5 0,000 0,03235117 0,10468067 ! peroxisome fission GO:0016559 5 5 0,000 0,03235117 0,1045422 ! histone demethylation GO:0016577 13 5 0,000 0,03235117 0,1044041 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03235117 0,10426636 ! mitotic recombination GO:0006312 9 5 0,000 0,03235117 0,10412899 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03235117 0,10399198 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03235117 0,10385533 ! metaphase plate congression GO:0051310 7 5 0,000 0,03235117 0,10371903 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03235117 0,1035831 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03235117 0,10344752 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03235117 0,10331229 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03235117 0,10317742 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03235117 0,1030429 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03235117 0,10290873 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03235117 0,10277491 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,03235117 0,10264143 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03235117 0,1025083 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03235117 0,10237552 ! metaphase GO:0051323 11 5 0,000 0,03235117 0,10224308 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03235117 0,10211099 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03235117 0,10197923 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03235117 0,10184781 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03235117 0,10171673 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03235117 0,10158599 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03235117 0,10145559 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03235117 0,10132552 ! response to redox state GO:0051775 6 5 0,000 0,03235117 0,10119578 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03235117 0,10106637 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03235117 0,1009373 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03235117 0,10080855 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03235117 0,10068013 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03235117 0,10055204 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03235117 0,10042427 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03235117 0,10029683 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03235117 0,10016971 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03235117 0,10004291 ! striatum development GO:0021756 14 5 0,000 0,03235117 0,09991644 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,03235117 0,09979028 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03235117 0,09966444 ! glial cell migration GO:0008347 10 5 0,000 0,03235117 0,09953892 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03235117 0,09941371 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03235117 0,09928882 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03235117 0,09916424 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03235117 0,09903998 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03235117 0,09891602 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03235117 0,09879238 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03235117 0,09866904 ! neuroprotection GO:0043526 8 5 0,000 0,03235117 0,09854601 ! regulation of sensory perception GO:0051931 8 5 0,000 0,03235117 0,09842329 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03235117 0,09830087 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03235117 0,09817876 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03235117 0,09805695 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03235117 0,09793544 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03235117 0,09781424 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03235117 0,09769333 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,03235117 0,09757272 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,03235117 0,09745241 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03235117 0,09733239 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03235117 0,09721267 ! spindle assembly GO:0051225 6 5 0,000 0,03235117 0,09709325 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03235117 0,09697411 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03235117 0,09685527 ! protein palmitoylation GO:0018345 12 5 0,000 0,03235117 0,09673672 ! drug metabolic process GO:0017144 7 5 0,000 0,03235117 0,09661846 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03235117 0,09650049 ! organ regeneration GO:0031100 7 5 0,000 0,03235117 0,09638281 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03235117 0,09626541 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03235117 0,0961483 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,03239757 0,09616922 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,03239757 0,09605251 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 1,000 0,03239757 0,09593608 ! segmentation GO:0035282 78 43 1,000 0,03239757 0,09581994 ! neuron migration GO:0001764 85 43 1,000 0,03239757 0,09570407 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,03239757 0,09558849 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,03379647 0,09959563 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,03379647 0,09947563 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,03379647 0,09935592 ! double-strand break repair GO:0006302 85 44 1,000 0,03379647 0,09923651 ! biopolymer methylation GO:0043414 91 45 1,000 0,03521858 0,10328811 ! female gamete generation GO:0007292 71 45 1,000 0,03521858 0,10316427 ! developmental growth GO:0048589 88 45 1,000 0,03521858 0,10304072 ! maintenance of location in cell GO:0051651 101 45 1,000 0,03521858 0,10291746 ! neural tube development GO:0021915 91 47 1,000 0,03813102 0,11129521 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,03813102 0,1111624 ! response to insulin stimulus GO:0032868 98 47 1,000 0,03813102 0,11102991 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03869525 0,11253867 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03869525 0,11240486 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03869525 0,11227136 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03869525 0,11213818 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03869525 0,11200531 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03869525 0,11187276 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03869525 0,11174053 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03869525 0,1116086 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03869525 0,11147699 ! response to oxygen radical GO:0000305 11 6 0,000 0,03869525 0,11134568 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03869525 0,11121469 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03869525 0,111084 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03869525 0,11095362 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03869525 0,11082355 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03869525 0,11069378 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03869525 0,11056431 ! forebrain regionalization GO:0021871 9 6 0,000 0,03869525 0,11043515 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03869525 0,11030628 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03869525 0,11017772 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03869525 0,11004946 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03869525 0,10992149 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03869525 0,10979383 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03869525 0,10966646 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03869525 0,10953938 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03869525 0,1094126 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03869525 0,10928611 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03869525 0,10915991 ! malate metabolic process GO:0006108 13 6 0,000 0,03869525 0,10903401 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03869525 0,10890839 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03869525 0,10878307 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03869525 0,10865803 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03869525 0,10853328 ! protein refolding GO:0042026 15 6 0,000 0,03869525 0,10840881 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03869525 0,10828463 ! opsonization GO:0008228 8 6 0,000 0,03869525 0,10816074 ! mating behavior GO:0007617 7 6 0,000 0,03869525 0,10803713 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03869525 0,1079138 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03869525 0,10779075 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03869525 0,10766798 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03869525 0,10754549 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03869525 0,10742328 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03869525 0,10730134 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03869525 0,10717969 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03869525 0,10705831 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03869525 0,1069372 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03869525 0,10681637 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03869525 0,10669581 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03869525 0,10657552 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03869525 0,1064555 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03869525 0,10633575 ! thymic T cell selection GO:0045061 16 6 0,000 0,03869525 0,10621627 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03869525 0,10609706 ! protein lipoylation GO:0009249 10 6 0,000 0,03869525 0,10597812 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03869525 0,10585945 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03869525 0,10574103 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03869525 0,10562289 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03869525 0,10550501 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03869525 0,10538739 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03869525 0,10527003 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03869525 0,10515293 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03869525 0,10503609 ! hyperosmotic response GO:0006972 10 6 0,000 0,03869525 0,10491952 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03869525 0,1048032 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03869525 0,10468714 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03869525 0,10457133 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03869525 0,10445578 ! urea metabolic process GO:0019627 7 6 0,000 0,03869525 0,10434049 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03869525 0,10422545 ! neutrophil activation GO:0042119 7 6 0,000 0,03869525 0,10411067 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03869525 0,10399613 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03869525 0,10388185 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03869525 0,10376782 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03869525 0,10365404 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03869525 0,10354051 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03869525 0,10342723 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03869525 0,10331419 ! folic acid transport GO:0015884 14 6 0,000 0,03869525 0,1032014 ! carnitine transport GO:0015879 10 6 0,000 0,03869525 0,10308886 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03869525 0,10297656 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03869525 0,10286451 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03869525 0,1027527 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03869525 0,10264113 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03869525 0,10252981 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03869525 0,10241873 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03869525 0,10230788 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03869525 0,10219728 ! establishment of spindle localization GO:0051293 16 6 0,000 0,03869525 0,10208692 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03869525 0,10197679 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03869525 0,1018669 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,03869525 0,10175725 ! astrocyte development GO:0014002 16 6 0,000 0,03869525 0,10164783 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03869525 0,10153865 ! interaction with symbiont GO:0051702 14 6 0,000 0,03869525 0,1014297 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03869525 0,10132099 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03869525 0,10121251 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03869525 0,10110426 ! response to copper ion GO:0046688 10 6 0,000 0,03869525 0,10099624 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03869525 0,10088846 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03869525 0,1007809 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03869525 0,10067357 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03869525 0,10056647 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03869525 0,1004596 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03869525 0,10035296 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03869525 0,10024654 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03869525 0,10014034 ! hair follicle maturation GO:0048820 8 6 0,000 0,03869525 0,10003438 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03869525 0,09992863 ! Schwann cell development GO:0014044 15 6 0,000 0,03869525 0,09982311 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03869525 0,09971781 ! response to pheromone GO:0019236 6 6 0,000 0,03869525 0,09961273 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03869525 0,09950788 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03869525 0,09940324 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03869525 0,09929883 ! subpallium development GO:0021544 15 6 0,000 0,03869525 0,09919463 ! neural tube patterning GO:0021532 8 6 0,000 0,03869525 0,09909065 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03869525 0,09898689 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03869525 0,09888335 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03869525 0,09878003 ! G2 phase GO:0051319 16 6 0,000 0,03869525 0,09867692 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03869525 0,09857402 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03869525 0,09847134 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03869525 0,09836887 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03869525 0,09826662 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03869525 0,09816457 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03869525 0,09806274 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03869525 0,09796112 ! receptor internalization GO:0031623 11 6 0,000 0,03869525 0,09785971 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03869525 0,09775852 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03869525 0,09765753 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03869525 0,09755674 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03869525 0,09745617 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03869525 0,0973558 ! protein deubiquitination GO:0016579 16 6 0,000 0,03869525 0,09725564 ! protein destabilization GO:0031648 9 6 0,000 0,03869525 0,09715569 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03869525 0,09705594 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03869525 0,09695639 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03869525 0,09685705 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03869525 0,09675792 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03869525 0,09665898 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03869525 0,09656025 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03869525 0,09646172 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03869525 0,09636339 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03869525 0,09626526 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03869525 0,09616733 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03869525 0,0960696 ! neural plate development GO:0001840 9 6 0,000 0,03869525 0,09597207 ! catecholamine transport GO:0051937 9 6 0,000 0,03869525 0,09587473 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03869525 0,09577759 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03869525 0,09568065 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03869525 0,09558391 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03869525 0,09548736 ! maternal placenta development GO:0001893 12 6 0,000 0,03869525 0,095391 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03869525 0,09529484 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03869525 0,09519888 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03869525 0,0951031 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03869525 0,09500752 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03869525 0,09491213 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03869525 0,09481694 GO:0055081|anion homeostasis, ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,03962064 0,09698719 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,03962064 0,09689011 ! endosome transport GO:0016197 127 48 1,000 0,03962064 0,09679322 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03962064 0,09669652 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,03962064 0,09660002 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,03962064 0,09650371 ! methylation GO:0032259 97 48 1,000 0,03962064 0,09640759 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,04113205 0,09998566 ! regulation of action potential GO:0001508 102 50 1,000 0,0426649 0,1036087 ! regulation of ossification GO:0030278 123 50 1,000 0,0426649 0,10350581 ! immunoglobulin mediated immune response GO:0016064 89 50 1,000 0,0426649 0,10340312 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,0426649 0,10330064 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,0426649 0,10319836 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,04421886 0,1068513 ! peptide metabolic process GO:0006518 80 51 1,000 0,04421886 0,10674572 ! response to temperature stimulus GO:0009266 84 51 1,000 0,04421886 0,10664034 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,04421886 0,10653517 ! tRNA transcription GO:0009304 17 7 0,000 0,04499791 0,10830531 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04499791 0,10819871 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,04499791 0,10809232 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04499791 0,10798614 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,04499791 0,10788017 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04499791 0,1077744 ! sleep GO:0030431 16 7 0,000 0,04499791 0,10766884 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04499791 0,10756349 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04499791 0,10745835 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04499791 0,10735341 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04499791 0,10724867 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04499791 0,10714414 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04499791 0,10703981 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04499791 0,10693569 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04499791 0,10683177 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04499791 0,10672805 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04499791 0,10662453 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04499791 0,10652121 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04499791 0,10641809 ! glycolipid transport GO:0046836 11 7 0,000 0,04499791 0,10631517 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04499791 0,10621245 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04499791 0,10610993 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04499791 0,10600761 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04499791 0,10590548 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04499791 0,10580355 ! pericardium development GO:0060039 16 7 0,000 0,04499791 0,10570182 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04499791 0,10560028 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04499791 0,10549893 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04499791 0,10539778 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04499791 0,10529683 ! lipoprotein transport GO:0042953 14 7 0,000 0,04499791 0,10519607 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04499791 0,1050955 ! rhythmic behavior GO:0007622 17 7 0,000 0,04499791 0,10499512 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04499791 0,10489493 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04499791 0,10479494 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04499791 0,10469513 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04499791 0,10459552 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04499791 0,10449609 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04499791 0,10439685 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04499791 0,10429781 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04499791 0,10419895 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04499791 0,10410027 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04499791 0,10400179 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04499791 0,10390349 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04499791 0,10380537 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04499791 0,10370744 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04499791 0,1036097 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04499791 0,10351214 ! spinal cord patterning GO:0021511 14 7 0,000 0,04499791 0,10341476 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04499791 0,10331756 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04499791 0,10322055 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04499791 0,10312372 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04499791 0,10302707 ! adrenal gland development GO:0030325 17 7 0,000 0,04499791 0,10293061 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04499791 0,10283432 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04499791 0,10273821 ! ovulation GO:0030728 10 7 0,000 0,04499791 0,10264229 ! adenohypophysis development GO:0021984 11 7 0,000 0,04499791 0,10254654 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04499791 0,10245097 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04499791 0,10235558 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04499791 0,10226036 ! microtubule nucleation GO:0007020 21 7 0,000 0,04499791 0,10216532 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04499791 0,10207046 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04499791 0,10197578 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04499791 0,10188127 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04499791 0,10178693 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04499791 0,10169277 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04499791 0,10159879 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04499791 0,10150498 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04499791 0,10141134 ! galactose metabolic process GO:0006012 13 7 0,000 0,04499791 0,10131787 ! vesicle fusion GO:0006906 20 7 0,000 0,04499791 0,10122457 ! response to dietary excess GO:0002021 8 7 0,000 0,04499791 0,10113145 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04499791 0,1010385 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04499791 0,10094572 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,04499791 0,10085311 ! nucleoside transport GO:0015858 11 7 0,000 0,04499791 0,10076067 ! nucleoside salvage GO:0043174 11 7 0,000 0,04499791 0,1006684 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04499791 0,10057629 ! male sex determination GO:0030238 15 7 0,000 0,04499791 0,10048436 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04499791 0,10039259 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04499791 0,10030099 ! parturition GO:0007567 16 7 0,000 0,04499791 0,10020956 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04499791 0,1001183 ! rRNA modification GO:0000154 14 7 0,000 0,04499791 0,1000272 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04499791 0,09993626 ! spindle checkpoint GO:0031577 16 7 0,000 0,04499791 0,09984549 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04499791 0,09975489 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04499791 0,09966445 ! monocyte differentiation GO:0030224 16 7 0,000 0,04499791 0,09957417 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04499791 0,09948406 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04499791 0,09939411 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04499791 0,09930433 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04499791 0,0992147 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04499791 0,09912524 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04499791 0,09903594 ! eating behavior GO:0042755 8 7 0,000 0,04499791 0,09894679 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04499791 0,09885781 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04499791 0,09876899 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04499791 0,09868033 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04499791 0,09859183 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,04499791 0,09850348 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04499791 0,0984153 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04499791 0,09832727 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04499791 0,0982394 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04499791 0,09815169 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04499791 0,09806413 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04499791 0,09797673 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04499791 0,09788948 ! histone ubiquitination GO:0016574 9 7 0,000 0,04499791 0,09780239 ! regulation of meiosis GO:0040020 12 7 0,000 0,04499791 0,09771546 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04499791 0,09762868 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04499791 0,09754205 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04499791 0,09745557 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04499791 0,09736925 ! transcription termination GO:0006353 14 7 0,000 0,04499791 0,09728309 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04499791 0,09719707 ! anaphase GO:0051322 18 7 0,000 0,04499791 0,09711121 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04499791 0,0970255 ! axonal fasciculation GO:0007413 19 7 0,000 0,04499791 0,09693994 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04499791 0,09685453 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04499791 0,09676927 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04499791 0,09668416 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04499791 0,0965992 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04499791 0,09651439 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04499791 0,09642973 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04499791 0,09634521 ! antibiotic transport GO:0042891 9 7 0,000 0,04499791 0,09626085 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04499791 0,09617663 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04499791 0,09609256 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04499791 0,09600864 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04499791 0,09592486 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04499791 0,09584123 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04499791 0,09575774 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04499791 0,0956744 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04499791 0,09559121 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04499791 0,09550816 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04499791 0,09542525 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04499791 0,09534249 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04499791 0,09525987 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04499791 0,09517739 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04499791 0,09509506 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04499791 0,09501287 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04499791 0,09493082 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04499791 0,09484891 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04499791 0,09476715 ! muscle adaptation GO:0043500 13 7 0,000 0,04499791 0,09468552 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04499791 0,09460403 ! retina homeostasis GO:0001895 12 7 0,000 0,04499791 0,09452269 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04499791 0,09444148 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04499791 0,09436042 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04499791 0,09427949 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04499791 0,0941987 ! positive regulation of binding GO:0051099 88 52 1,000 0,04579358 0,09578228 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,04579358 0,09570035 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,04579358 0,09561855 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,04579358 0,0955369 ! histone modification GO:0016570 104 52 1,000 0,04579358 0,09545538 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,04579358 0,095374 ! inner ear development GO:0048839 89 53 1,000 0,04738872 0,09861214 ! chromatin remodeling GO:0006338 122 53 1,000 0,04738872 0,09852821 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,04738872 0,09844443 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,04738872 0,09836079 ! vesicle organization GO:0016050 127 53 1,000 0,04738872 0,09827729 ! synapse organization GO:0050808 102 53 1,000 0,04738872 0,09819394 ! covalent chromatin modification GO:0016569 115 54 1,000 0,04900396 0,10145482 ! glutamine family amino acid metabolic process GO:0009064 85 54 1,000 0,04900396 0,10136891 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 0,05063897 0,10466244 ! cell maturation GO:0048469 107 55 1,000 0,05063897 0,10457397 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,05125942 0,10576585 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,05125942 0,1056766 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,05125942 0,1055875 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,05125942 0,10549854 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,05125942 0,10540974 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,05125942 0,10532109 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05125942 0,10523258 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05125942 0,10514422 ! male meiosis GO:0007140 9 8 0,000 0,05125942 0,10505602 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,05125942 0,10496796 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,05125942 0,10488004 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,05125942 0,10479228 ! meiotic prophase I GO:0007128 14 8 0,000 0,05125942 0,10470466 ! response to zinc ion GO:0010043 12 8 0,000 0,05125942 0,10461719 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,05125942 0,10452986 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05125942 0,10444268 ! oligopeptide transport GO:0006857 16 8 0,000 0,05125942 0,10435564 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,05125942 0,10426875 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,05125942 0,10418201 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,05125942 0,1040954 ! signal peptide processing GO:0006465 12 8 0,000 0,05125942 0,10400895 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,05125942 0,10392263 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,05125942 0,10383646 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05125942 0,10375043 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,05125942 0,10366455 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,05125942 0,1035788 ! estrogen metabolic process GO:0008210 17 8 0,000 0,05125942 0,1034932 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,05125942 0,10340774 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,05125942 0,10332242 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05125942 0,10323724 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05125942 0,1031522 ! reflex GO:0060004 17 8 0,000 0,05125942 0,1030673 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05125942 0,10298254 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05125942 0,10289792 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,05125942 0,10281344 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,05125942 0,1027291 ! astrocyte differentiation GO:0048708 19 8 0,000 0,05125942 0,10264489 ! histidine catabolic process GO:0006548 10 8 0,000 0,05125942 0,10256083 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05125942 0,1024769 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,05125942 0,10239311 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,05125942 0,10230945 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,05125942 0,10222594 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,05125942 0,10214255 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,05125942 0,10205931 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,05125942 0,1019762 ! macrophage activation GO:0042116 13 8 0,000 0,05125942 0,10189322 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05125942 0,10181038 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,05125942 0,10172768 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05125942 0,10164511 ! purine salvage GO:0043101 12 8 0,000 0,05125942 0,10156267 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,05125942 0,10148037 ! osteoblast development GO:0002076 17 8 0,000 0,05125942 0,1013982 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,05125942 0,10131616 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,05125942 0,10123425 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,05125942 0,10115248 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,05125942 0,10107084 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05125942 0,10098933 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,05125942 0,10090795 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05125942 0,10082671 ! intermediate filament organization GO:0045109 12 8 0,000 0,05125942 0,10074559 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,05125942 0,10066461 ! cellular extravasation GO:0045123 13 8 0,000 0,05125942 0,10058375 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,05125942 0,10050303 ! response to antibiotic GO:0046677 11 8 0,000 0,05125942 0,10042243 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,05125942 0,10034196 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,05125942 0,10026163 ! DNA topological change GO:0006265 12 8 0,000 0,05125942 0,10018142 ! response to tropane GO:0014073 15 8 0,000 0,05125942 0,10010134 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05125942 0,10002138 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,05125942 0,09994156 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05125942 0,09986186 ! mast cell activation GO:0045576 14 8 0,000 0,05125942 0,09978229 ! multicellular organismal aging GO:0010259 20 8 0,000 0,05125942 0,09970284 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,05125942 0,09962353 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,05125942 0,09954433 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,05125942 0,09946527 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,05125942 0,09938633 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05125942 0,09930751 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05125942 0,09922882 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,05125942 0,09915025 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05125942 0,09907181 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,05125942 0,0989935 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,05125942 0,0989153 ! intracellular lipid transport GO:0032365 16 8 0,000 0,05125942 0,09883723 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05125942 0,09875928 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,05125942 0,09868146 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,05125942 0,09860376 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05125942 0,09852618 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,05125942 0,09844872 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,05125942 0,09837138 ! hormone catabolic process GO:0042447 17 8 0,000 0,05125942 0,09829417 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,05125942 0,09821708 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,05125942 0,0981401 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,05125942 0,09806325 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,05125942 0,09798652 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05125942 0,09790991 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,05125942 0,09783342 ! adult feeding behavior GO:0008343 10 8 0,000 0,05125942 0,09775704 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,05125942 0,09768079 ! ATP catabolic process GO:0006200 11 8 0,000 0,05125942 0,09760465 ! blastocyst growth GO:0001832 19 8 0,000 0,05125942 0,09752864 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05125942 0,09745274 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05125942 0,09737696 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,05125942 0,0973013 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05125942 0,09722575 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,05125942 0,09715033 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,05125942 0,09707502 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,05125942 0,09699982 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,05125942 0,09692475 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,05125942 0,09684978 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05125942 0,09677494 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,05125942 0,09670021 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,05125942 0,0966256 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05125942 0,0965511 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,05125942 0,09647671 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,05125942 0,09640244 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,05125942 0,09632829 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,05125942 0,09625424 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,05125942 0,09618032 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,05229341 0,09804513 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,05229341 0,09796995 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,05229341 0,09789487 ! RNA elongation GO:0006354 90 56 1,000 0,05229341 0,09781992 ! muscle fiber development GO:0048747 131 57 1,000 0,05396697 0,10087323 ! heart morphogenesis GO:0003007 105 57 1,000 0,05396697 0,10079611 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,05396697 0,10071911 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,05565933 0,10379828 ! gastrulation GO:0007369 122 58 1,000 0,05565933 0,1037191 ! maintenance of location GO:0051235 124 58 1,000 0,05565933 0,10364005 ! axon extension GO:0048675 16 9 0,000 0,05748006 0,10694881 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05748006 0,10686742 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,05748006 0,10678615 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05748006 0,10670501 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05748006 0,10662398 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,05748006 0,10654309 ! reproductive behavior GO:0019098 22 9 0,000 0,05748006 0,10646231 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05748006 0,10638166 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,05748006 0,10630113 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05748006 0,10622072 ! UTP metabolic process GO:0046051 10 9 0,000 0,05748006 0,10614043 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05748006 0,10606026 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,05748006 0,10598022 ! artery development GO:0060840 25 9 0,000 0,05748006 0,10590029 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,05748006 0,10582049 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,05748006 0,1057408 ! equilibrioception GO:0050957 20 9 0,000 0,05748006 0,10566124 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,05748006 0,1055818 ! chemosensory behavior GO:0007635 21 9 0,000 0,05748006 0,10550247 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05748006 0,10542326 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05748006 0,10534418 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,05748006 0,10526521 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05748006 0,10518636 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05748006 0,10510763 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,05748006 0,10502901 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05748006 0,10495051 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05748006 0,10487213 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05748006 0,10479387 ! protein targeting to ER GO:0045047 25 9 0,000 0,05748006 0,10471573 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05748006 0,1046377 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05748006 0,10455978 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,05748006 0,10448198 ! glycine catabolic process GO:0006546 15 9 0,000 0,05748006 0,1044043 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05748006 0,10432674 ! endosome organization GO:0007032 20 9 0,000 0,05748006 0,10424929 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05748006 0,10417195 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05748006 0,10409473 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05748006 0,10401762 ! mannose metabolic process GO:0006013 13 9 0,000 0,05748006 0,10394063 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05748006 0,10386375 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05748006 0,10378698 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,05748006 0,10371033 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05748006 0,10363379 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05748006 0,10355737 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05748006 0,10348105 ! retinol metabolic process GO:0042572 20 9 0,000 0,05748006 0,10340485 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05748006 0,10332876 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,05748006 0,10325278 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05748006 0,10317692 ! macrophage differentiation GO:0030225 15 9 0,000 0,05748006 0,10310117 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05748006 0,10302552 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,05748006 0,10294999 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05748006 0,10287457 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05748006 0,10279926 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05748006 0,10272406 ! response to amine stimulus GO:0014075 13 9 0,000 0,05748006 0,10264897 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05748006 0,10257399 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05748006 0,10249911 ! erythrocyte development GO:0048821 17 9 0,000 0,05748006 0,10242435 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05748006 0,1023497 ! renal water homeostasis GO:0003091 15 9 0,000 0,05748006 0,10227515 ! postreplication repair GO:0006301 25 9 0,000 0,05748006 0,10220072 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05748006 0,10212639 ! icosanoid secretion GO:0032309 15 9 0,000 0,05748006 0,10205217 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05748006 0,10197806 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05748006 0,10190405 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05748006 0,10183016 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05748006 0,10175637 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05748006 0,10168268 ! sterol catabolic process GO:0016127 14 9 0,000 0,05748006 0,10160911 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05748006 0,10153564 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05748006 0,10146227 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05748006 0,10138902 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05748006 0,10131586 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,05748006 0,10124282 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,05748006 0,10116988 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,05748006 0,10109704 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,05748006 0,10102431 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05748006 0,10095168 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05748006 0,10087916 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05748006 0,10080674 ! pigment granule transport GO:0051904 17 9 0,000 0,05748006 0,10073442 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05748006 0,10066221 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05748006 0,10059011 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05748006 0,1005181 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05748006 0,1004462 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05748006 0,1003744 ! mitochondrion localization GO:0051646 18 9 0,000 0,05748006 0,10030271 ! lipid modification GO:0030258 112 60 1,000 0,05909917 0,10305444 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,06084603 0,10602487 ! nucleoside metabolic process GO:0009116 91 62 1,000 0,06261045 0,10902162 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,06366008 0,11077036 ! regulation of developmental growth GO:0048638 16 10 0,000 0,06366008 0,11069152 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,06366008 0,11061279 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06366008 0,11053418 ! associative learning GO:0008306 21 10 0,000 0,06366008 0,11045567 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06366008 0,11037728 ! phosphate transport GO:0006817 24 10 0,000 0,06366008 0,110299 ! cell volume homeostasis GO:0006884 17 10 0,000 0,06366008 0,11022083 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,06366008 0,11014277 ! CTP metabolic process GO:0046036 11 10 0,000 0,06366008 0,11006482 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,06366008 0,10998698 ! GTP metabolic process GO:0046039 11 10 0,000 0,06366008 0,10990925 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,06366008 0,10983163 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,06366008 0,10975412 ! social behavior GO:0035176 29 10 0,000 0,06366008 0,10967672 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,06366008 0,10959943 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,06366008 0,10952224 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,06366008 0,10944517 ! androgen metabolic process GO:0008209 17 10 0,000 0,06366008 0,1093682 ! phospholipid efflux GO:0033700 19 10 0,000 0,06366008 0,10929135 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,06366008 0,1092146 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,06366008 0,10913795 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,06366008 0,10906142 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,06366008 0,10898499 ! pathogenesis GO:0009405 17 10 0,000 0,06366008 0,10890867 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06366008 0,10883246 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,06366008 0,10875635 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,06366008 0,10868035 ! endoderm development GO:0007492 18 10 0,000 0,06366008 0,10860446 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,06366008 0,10852867 ! arginine catabolic process GO:0006527 17 10 0,000 0,06366008 0,10845299 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06366008 0,10837741 ! proline metabolic process GO:0006560 13 10 0,000 0,06366008 0,10830194 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,06366008 0,10822657 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,06366008 0,10815131 ! V(D)J recombination GO:0033151 34 10 0,000 0,06366008 0,10807615 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,06366008 0,1080011 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,06366008 0,10792615 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,06366008 0,10785131 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,06366008 0,10777657 ! multicellular organism growth GO:0035264 19 10 0,000 0,06366008 0,10770193 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,06366008 0,10762739 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,06366008 0,10755296 ! ruffle organization GO:0031529 17 10 0,000 0,06366008 0,10747864 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,06366008 0,10740441 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06366008 0,10733029 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,06366008 0,10725627 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,06366008 0,10718235 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,06366008 0,10710853 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,06366008 0,10703481 ! protein heterooligomerization GO:0051291 17 10 0,000 0,06366008 0,1069612 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,06366008 0,10688769 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,06366008 0,10681428 ! segment specification GO:0007379 15 10 0,000 0,06366008 0,10674096 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,06366008 0,10666775 ! blastoderm segmentation GO:0007350 19 10 0,000 0,06366008 0,10659464 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,06366008 0,10652163 ! response to dsRNA GO:0043331 23 10 0,000 0,06366008 0,10644872 ! DNA ligation GO:0006266 18 10 0,000 0,06366008 0,10637591 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,06366008 0,1063032 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06366008 0,10623059 ! melanosome localization GO:0032400 16 10 0,000 0,06366008 0,10615808 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,06366008 0,10608567 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,06366008 0,10601335 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,06366008 0,10594113 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06366008 0,10586902 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,06366008 0,105797 ! induction of an organ GO:0001759 17 10 0,000 0,06366008 0,10572508 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,06366008 0,10565325 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,06366008 0,10558152 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,06366008 0,1055099 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,06366008 0,10543836 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06366008 0,10536693 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,06366008 0,10529559 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,06366008 0,10522435 ! salivary gland development GO:0007431 28 10 0,000 0,06366008 0,1051532 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,06366008 0,10508215 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,06366008 0,1050112 ! midbrain development GO:0030901 14 10 0,000 0,06366008 0,10494034 ! musculoskeletal movement GO:0050881 16 10 0,000 0,06366008 0,10486958 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,06366008 0,10479891 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,06366008 0,10472834 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,06366008 0,10465786 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,06366008 0,10458748 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,06366008 0,10451719 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06366008 0,104447 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06366008 0,1043769 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,06366008 0,1043069 ! detection of calcium ion GO:0005513 24 10 0,000 0,06366008 0,10423699 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06366008 0,10416717 ! blastocyst formation GO:0001825 18 10 0,000 0,06366008 0,10409745 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,06366008 0,10402782 ! cerebellar cortex development GO:0021695 16 10 0,000 0,06366008 0,10395828 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,06366008 0,10388883 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,06366008 0,10381948 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,06366008 0,10375022 ! mesoderm development GO:0007498 128 63 1,000 0,06439212 0,10487329 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,06619073 0,10773082 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,068006 0,11061162 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,068006 0,11053803 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 0,068006 0,11046453 ! respiratory burst GO:0045730 17 11 0,000 0,06979976 0,11330286 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,06979976 0,11322763 ! neuron fate specification GO:0048665 18 11 0,000 0,06979976 0,1131525 ! telencephalon cell migration GO:0022029 23 11 0,000 0,06979976 0,11307746 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06979976 0,11300253 ! thyroid gland development GO:0030878 26 11 0,000 0,06979976 0,11292769 ! synapsis GO:0007129 14 11 0,000 0,06979976 0,11285295 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06979976 0,11277831 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,06979976 0,11270377 ! response to pain GO:0048265 27 11 0,000 0,06979976 0,11262933 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06979976 0,11255499 ! bone resorption GO:0045453 16 11 0,000 0,06979976 0,11248075 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06979976 0,1124066 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06979976 0,11233255 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06979976 0,1122586 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06979976 0,11218474 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06979976 0,11211099 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06979976 0,11203733 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,06979976 0,11196376 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,06979976 0,1118903 ! UV protection GO:0009650 20 11 0,000 0,06979976 0,11181693 ! adult heart development GO:0007512 16 11 0,000 0,06979976 0,11174365 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06979976 0,11167047 ! macroautophagy GO:0016236 19 11 0,000 0,06979976 0,11159739 ! temperature homeostasis GO:0001659 18 11 0,000 0,06979976 0,1115244 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06979976 0,11145151 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,06979976 0,11137871 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06979976 0,11130601 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,06979976 0,11123341 ! regulation of organ growth GO:0046620 14 11 0,000 0,06979976 0,11116089 ! pigment granule localization GO:0051875 20 11 0,000 0,06979976 0,11108848 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06979976 0,11101615 ! vasoconstriction GO:0042310 20 11 0,000 0,06979976 0,11094392 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06979976 0,11087179 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06979976 0,11079975 ! embryonic axis specification GO:0000578 19 11 0,000 0,06979976 0,1107278 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06979976 0,11065594 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06979976 0,11058418 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06979976 0,11051252 ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06979976 0,11044094 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06979976 0,11036946 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06979976 0,11029807 ! prophase GO:0051324 17 11 0,000 0,06979976 0,11022677 ! neuroblast proliferation GO:0007405 25 11 0,000 0,06979976 0,11015556 ! nucleosome positioning GO:0016584 15 11 0,000 0,06979976 0,11008445 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06979976 0,11001343 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06979976 0,1099425 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06979976 0,10987166 ! acid secretion GO:0046717 20 11 0,000 0,06979976 0,10980091 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06979976 0,10973025 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06979976 0,10965969 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06979976 0,10958921 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06979976 0,10951883 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06979976 0,10944853 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,06979976 0,10937833 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06979976 0,10930821 ! germ cell migration GO:0008354 26 11 0,000 0,06979976 0,10923819 ! embryonic gut development GO:0048566 19 11 0,000 0,06979976 0,10916825 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,06979976 0,10909841 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,06979976 0,10902865 ! activation of innate immune response GO:0002218 16 11 0,000 0,06979976 0,10895898 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06979976 0,10888941 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,06979976 0,10881992 ! lysogeny GO:0030069 22 11 0,000 0,06979976 0,10875052 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06979976 0,10868121 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06979976 0,10861198 ! sequestering of metal ion GO:0051238 15 11 0,000 0,06979976 0,10854285 ! regulation of embryonic development GO:0045995 35 11 0,000 0,06979976 0,1084738 ! nucleus localization GO:0051647 22 11 0,000 0,06979976 0,10840484 ! gonad development GO:0008406 115 66 1,000 0,06983763 0,10839474 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,06983763 0,10832592 ! activation of MAPK activity GO:0000187 124 67 1,000 0,07168533 0,11112135 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,07168533 0,11105089 GO:0035113|embryonic appendage morphogenesis, ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,07354881 0,11386549 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,07354881 0,11379337 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,07354881 0,11372135 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,07354881 0,11364942 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,07354881 0,11357758 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,07542779 0,11640561 ! developmental maturation GO:0021700 128 69 1,000 0,07542779 0,11633212 ! single fertilization GO:0007338 83 69 1,000 0,07542779 0,11625873 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,07589935 0,11691179 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,07589935 0,11683812 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,07589935 0,11676455 ! virus-host interaction GO:0019048 30 12 0,000 0,07589935 0,11669107 ! mating GO:0007618 17 12 0,000 0,07589935 0,11661768 ! protein complex disassembly GO:0043241 28 12 0,000 0,07589935 0,11654438 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 29 12 0,000 0,07589935 0,11647117 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,07589935 0,11639806 ! T cell proliferation GO:0042098 32 12 0,000 0,07589935 0,11632503 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,07589935 0,1162521 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,07589935 0,11617926 ! ventral spinal cord development GO:0021517 25 12 0,000 0,07589935 0,11610651 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,07589935 0,11603386 ! drug transport GO:0015893 16 12 0,000 0,07589935 0,11596129 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,07589935 0,11588882 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,07589935 0,11581643 ! polyamine metabolic process GO:0006595 18 12 0,000 0,07589935 0,11574413 ! mitotic spindle organization GO:0007052 23 12 0,000 0,07589935 0,11567193 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,07589935 0,11559982 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,07589935 0,11552779 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,07589935 0,11545586 ! lipid digestion GO:0044241 21 12 0,000 0,07589935 0,11538401 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,07589935 0,11531225 ! entry into host cell GO:0030260 34 12 0,000 0,07589935 0,11524059 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07589935 0,11516901 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,07589935 0,11509752 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,07589935 0,11502612 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,07589935 0,11495481 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,07589935 0,11488358 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,07589935 0,11481245 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,07589935 0,1147414 ! snRNA metabolic process GO:0016073 30 12 0,000 0,07589935 0,11467044 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,07589935 0,11459957 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,07589935 0,11452879 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,07589935 0,11445809 ! fucose catabolic process GO:0019317 25 12 0,000 0,07589935 0,11438748 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,07589935 0,11431696 ! zymogen activation GO:0031638 18 12 0,000 0,07589935 0,11424652 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,07589935 0,11417617 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,07589935 0,11410591 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,07589935 0,11403573 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,07589935 0,11396564 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,07589935 0,11389564 ! defense response to fungus GO:0050832 15 12 0,000 0,07589935 0,11382572 ! developmental induction GO:0031128 22 12 0,000 0,07589935 0,11375589 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,07589935 0,11368615 ! response to cold GO:0009409 17 12 0,000 0,07589935 0,11361649 ! establishment of cell polarity GO:0030010 21 12 0,000 0,07589935 0,11354691 ! regulation of synapse organization GO:0050807 18 12 0,000 0,07589935 0,11347742 ! localization within membrane GO:0051668 26 12 0,000 0,07589935 0,11340801 ! germ cell development GO:0007281 133 70 1,000 0,07732198 0,11546308 ! activation of immune response GO:0002253 120 70 1,000 0,07732198 0,11539255 ! protein maturation by peptide bond cleavage GO:0051605 118 70 1,000 0,07732198 0,1153221 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,07923112 0,11809739 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,07923112 0,11802538 ! appendage morphogenesis GO:0035107 150 72 1,000 0,08115491 0,12081746 GO:0035108|limb morphogenesis, ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,08115491 0,12074388 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,08195911 0,12186616 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08195911 0,12179203 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,08195911 0,121718 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,08195911 0,12164405 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,08195911 0,12157019 ! peroxisomal transport GO:0043574 28 13 0,000 0,08195911 0,12149642 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,08195911 0,12142274 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,08195911 0,12134915 ! organelle fusion GO:0048284 36 13 0,000 0,08195911 0,12127565 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,08195911 0,12120224 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,08195911 0,12112892 ! endocrine pancreas development GO:0031018 25 13 0,000 0,08195911 0,12105568 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,08195911 0,12098254 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,08195911 0,12090948 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,08195911 0,12083651 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,08195911 0,12076363 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,08195911 0,12069084 ! methionine metabolic process GO:0006555 31 13 0,000 0,08195911 0,12061813 ! plasma membrane organization GO:0007009 27 13 0,000 0,08195911 0,12054552 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,08195911 0,12047299 ! Golgi organization GO:0007030 25 13 0,000 0,08195911 0,12040054 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,08195911 0,12032819 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,08195911 0,12025592 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,08195911 0,12018373 ! exocrine system development GO:0035272 34 13 0,000 0,08195911 0,12011164 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,08195911 0,12003963 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,08195911 0,11996771 ! L-glutamate transport GO:0015813 30 13 0,000 0,08195911 0,11989587 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,08195911 0,11982412 ! protein homotetramerization GO:0051289 24 13 0,000 0,08195911 0,11975245 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,08195911 0,11968087 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,08195911 0,11960938 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,08195911 0,11953797 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,08195911 0,11946665 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,08195911 0,11939541 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,08195911 0,11932426 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,08195911 0,11925319 ! histone methylation GO:0016571 29 13 0,000 0,08195911 0,1191822 ! chromatin silencing GO:0006342 29 13 0,000 0,08195911 0,1191113 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,08195911 0,11904049 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08195911 0,11896976 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,08195911 0,11889911 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,08195911 0,11882855 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,08195911 0,11875807 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,08195911 0,11868767 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,08195911 0,11861736 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,08195911 0,11854713 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,08195911 0,11847698 ! insulin secretion GO:0030073 24 13 0,000 0,08195911 0,11840692 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,08195911 0,11833694 ! acrosome reaction GO:0007340 19 13 0,000 0,08195911 0,11826704 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,08195911 0,11819723 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,08195911 0,11812749 ! appendage development GO:0048736 151 73 1,000 0,0830931 0,1196913 GO:0060173|limb development, ! acute inflammatory response GO:0002526 118 74 1,000 0,08504541 0,12243132 ! amino acid transport GO:0006865 148 74 1,000 0,08504541 0,12235921 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,08701158 0,12511435 ! axon guidance GO:0007411 162 75 1,000 0,08701158 0,12504076 ! rhythmic process GO:0048511 142 75 1,000 0,08701158 0,12496725 ! rRNA transcription GO:0009303 28 14 0,000 0,0879793 0,12628287 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,0879793 0,12620871 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,0879793 0,12613465 ! water transport GO:0006833 21 14 0,000 0,0879793 0,12606067 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,0879793 0,12598677 ! non-recombinational repair GO:0000726 29 14 0,000 0,0879793 0,12591297 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,0879793 0,12583925 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,0879793 0,12576562 ! lipid localization GO:0010876 32 14 0,000 0,0879793 0,12569207 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,0879793 0,12561861 ! regulated secretory pathway GO:0045055 24 14 0,000 0,0879793 0,12554523 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,0879793 0,12547194 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,0879793 0,12539874 ! arginine metabolic process GO:0006525 21 14 0,000 0,0879793 0,12532562 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,0879793 0,12525259 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,0879793 0,12517964 ! regulation of heart rate GO:0002027 25 14 0,000 0,0879793 0,12510677 ! organic alcohol transport GO:0015850 29 14 0,000 0,0879793 0,12503399 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,0879793 0,1249613 ! embryo implantation GO:0007566 30 14 0,000 0,0879793 0,12488869 ! neutral amino acid transport GO:0015804 28 14 0,000 0,0879793 0,12481617 ! bone mineralization GO:0030282 18 14 0,000 0,0879793 0,12474372 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,0879793 0,12467137 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,0879793 0,12459909 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,0879793 0,1245269 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,0879793 0,1244548 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,0879793 0,12438278 ! ribosome assembly GO:0042255 18 14 0,000 0,0879793 0,12431084 ! cerebellum development GO:0021549 23 14 0,000 0,0879793 0,12423898 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,0879793 0,12416721 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,0879793 0,12409552 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,0879793 0,12402391 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,0879793 0,12395239 ! NADP metabolic process GO:0006739 24 14 0,000 0,0879793 0,12388094 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,0879793 0,12380958 ! oxygen transport GO:0015671 22 14 0,000 0,0879793 0,12373831 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,0879793 0,12366711 ! regulation of axon extension GO:0030516 43 14 0,000 0,0879793 0,123596 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,0879793 0,12352496 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,0879793 0,12345401 ! learning or memory GO:0007611 161 76 1,000 0,08899134 0,12480243 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,09098442 0,12752435 ! fertilization GO:0009566 99 78 1,000 0,09299059 0,13026147 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,09299059 0,13018682 ! lactation GO:0007595 30 15 0,000 0,09396019 0,13146892 ! reproductive cellular process GO:0048610 22 15 0,000 0,09396019 0,13139367 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,09396019 0,1313185 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,09396019 0,13124342 ! superoxide anion generation GO:0042554 22 15 0,000 0,09396019 0,13116842 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,09396019 0,13109351 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,09396019 0,13101869 ! copper ion transport GO:0006825 22 15 0,000 0,09396019 0,13094395 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,09396019 0,13086929 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,09396019 0,13079472 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,09396019 0,13072024 ! sulfate transport GO:0008272 27 15 0,000 0,09396019 0,13064584 ! response to cAMP GO:0051591 25 15 0,000 0,09396019 0,13057152 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,09396019 0,13049729 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,09396019 0,13042315 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,09396019 0,13034908 ! response to hexose stimulus GO:0009746 25 15 0,000 0,09396019 0,13027511 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,09396019 0,13020121 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,09396019 0,1301274 ! vesicle coating GO:0006901 38 15 0,000 0,09396019 0,13005368 ! regulation of exocytosis GO:0017157 26 15 0,000 0,09396019 0,12998003 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,09396019 0,12990647 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,09396019 0,129833 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,09396019 0,1297596 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,09396019 0,12968629 ! regulation of vasodilation GO:0042312 27 15 0,000 0,09396019 0,12961306 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,09396019 0,12953992 ! histone deacetylation GO:0016575 24 15 0,000 0,09396019 0,12946686 ! water homeostasis GO:0030104 28 15 0,000 0,09396019 0,12939388 ! cofactor transport GO:0051181 30 15 0,000 0,09396019 0,12932098 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,09396019 0,12924816 ! intestinal absorption GO:0050892 31 15 0,000 0,09396019 0,12917543 ! dopamine metabolic process GO:0042417 35 15 0,000 0,09396019 0,12910278 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,09396019 0,12903021 ! heme biosynthetic process GO:0006783 33 15 0,000 0,09396019 0,12895772 ! cell killing GO:0001906 32 15 0,000 0,09396019 0,12888531 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,09396019 0,12881298 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,09396019 0,12874074 ! actin filament polymerization GO:0030041 27 15 0,000 0,09396019 0,12866857 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,09396019 0,12859649 ! blood coagulation GO:0007596 151 79 1,000 0,09500956 0,12995989 GO:0050817|coagulation, ! steroid biosynthetic process GO:0006694 146 79 1,000 0,09500956 0,12988717 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,09500956 0,12981452 ! protein oligomerization GO:0051259 149 79 1,000 0,09500956 0,12974196 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,09704111 0,13244214 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,09704111 0,13236819 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,09704111 0,13229432 ! meiosis GO:0007126 143 81 1,000 0,09908497 0,13500534 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,09908497 0,13493009 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,09990202 0,13596692 ! positive regulation of cell size GO:0045793 29 16 0,000 0,09990202 0,13589122 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,09990202 0,1358156 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,09990202 0,13574006 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,09990202 0,13566461 ! bone remodeling GO:0046849 28 16 0,000 0,09990202 0,13558924 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,09990202 0,13551395 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,09990202 0,13543875 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09990202 0,13536363 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,09990202 0,1352886 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,09990202 0,13521364 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,09990202 0,13513878 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,09990202 0,13506399 ! startle response GO:0001964 28 16 0,000 0,09990202 0,13498929 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,09990202 0,13491466 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,09990202 0,13484013 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,09990202 0,13476567 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,09990202 0,1346913 ! protein polyubiquitination GO:0000209 41 16 0,000 0,09990202 0,134617 ! glutamate metabolic process GO:0006536 25 16 0,000 0,09990202 0,13454279 ! pituitary gland development GO:0021983 30 16 0,000 0,09990202 0,13446867 ! response to osmotic stress GO:0006970 27 16 0,000 0,09990202 0,13439462 ! lysosomal transport GO:0007041 31 16 0,000 0,09990202 0,13432065 ! fructose metabolic process GO:0006000 25 16 0,000 0,09990202 0,13424677 ! L-amino acid transport GO:0015807 33 16 0,000 0,09990202 0,13417297 ! stem cell development GO:0048864 46 16 0,000 0,09990202 0,13409925 GO:0019827|stem cell maintenance, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,09990202 0,13402561 ! intermediate filament-based process GO:0045103 36 16 0,000 0,09990202 0,13395205 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,09990202 0,13387857 ! negative regulation of immune response GO:0050777 38 16 0,000 0,09990202 0,13380517 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,09990202 0,13373185 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,09990202 0,13365861 ! DNA replication initiation GO:0006270 28 16 0,000 0,09990202 0,13358546 ! neuron recognition GO:0008038 40 16 0,000 0,09990202 0,13351238 ! mRNA splice site selection GO:0006376 44 16 0,000 0,09990202 0,13343938 ! tissue regeneration GO:0042246 27 16 0,000 0,09990202 0,13336646 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,09990202 0,13329363 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,09990202 0,13322087 ! biomineral formation GO:0031214 22 16 0,000 0,09990202 0,13314819 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,09990202 0,13307559 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,09990202 0,13300307 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,09990202 0,13293063 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,09990202 0,13285826 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,09990202 0,13278598 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,09990202 0,13271377 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,09990202 0,13264165 ! peptide hormone processing GO:0016486 27 16 0,000 0,09990202 0,1325696 ! protein import into nucleus GO:0006606 174 82 1,000 0,1011409 0,13414072 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,10320865 0,13680886 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,10320865 0,13673467 ! nuclear import GO:0051170 177 83 1,000 0,10320865 0,13666056 ! response to metal ion GO:0010038 158 84 1,000 0,10528798 0,13933832 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,10580505 0,13994679 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,10580505 0,13987107 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,10580505 0,13979542 ! filopodium assembly GO:0046847 42 17 0,000 0,10580505 0,13971985 ! endothelial cell migration GO:0043542 31 17 0,000 0,10580505 0,13964437 ! gene silencing by RNA GO:0031047 38 17 0,000 0,10580505 0,13956897 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,10580505 0,13949365 ! glial cell development GO:0021782 28 17 0,000 0,10580505 0,13941841 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,10580505 0,13934325 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,10580505 0,13926817 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,10580505 0,13919318 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,10580505 0,13911826 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,10580505 0,13904343 ! myoblast differentiation GO:0045445 50 17 0,000 0,10580505 0,13896867 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,10580505 0,138894 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,10580505 0,1388194 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,10580505 0,13874489 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,10580505 0,13867046 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,10580505 0,1385961 ! NAD metabolic process GO:0019674 33 17 0,000 0,10580505 0,13852183 ! membrane budding GO:0006900 42 17 0,000 0,10580505 0,13844763 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,10580505 0,13837352 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,10580505 0,13829948 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,10580505 0,13822552 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,10580505 0,13815165 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,10580505 0,13807785 ! steroid catabolic process GO:0006706 34 17 0,000 0,10580505 0,13800413 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,10580505 0,13793049 ! gas transport GO:0015669 26 17 0,000 0,10580505 0,13785692 ! organic cation transport GO:0015695 32 17 0,000 0,10580505 0,13778344 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,10580505 0,13771003 ! hemostasis GO:0007599 165 85 1,000 0,10737866 0,13968374 ! cholesterol metabolic process GO:0008203 148 85 1,000 0,10737866 0,1396094 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,10737866 0,13953514 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,10948045 0,14219071 ! regulation of lyase activity GO:0051339 169 86 1,000 0,10948045 0,14211516 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,10948045 0,14203969 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,11166953 0,1448029 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,11166953 0,14472608 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,11166953 0,14464934 ! limbic system development GO:0021761 40 18 0,000 0,11166953 0,14457268 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,11166953 0,14449611 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,11166953 0,14441962 ! adult walking behavior GO:0007628 36 18 0,000 0,11166953 0,1443432 ! patterning of blood vessels GO:0001569 43 18 0,000 0,11166953 0,14426687 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,11166953 0,14419062 ! centrosome cycle GO:0007098 26 18 0,000 0,11166953 0,14411445 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,11166953 0,14403836 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,11166953 0,14396235 ! glycine metabolic process GO:0006544 30 18 0,000 0,11166953 0,14388642 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 0,11166953 0,14381057 ! DNA integration GO:0015074 32 18 0,000 0,11166953 0,1437348 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,11166953 0,14365911 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,11166953 0,1435835 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,11166953 0,14350797 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,11166953 0,14343252 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,11166953 0,14335715 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,11166953 0,14328186 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,11166953 0,14320664 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,11166953 0,14313151 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,11166953 0,14305645 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,11166953 0,14298148 ! detection of bacterium GO:0016045 22 18 0,000 0,11166953 0,14290658 ! microspike assembly GO:0030035 46 18 0,000 0,11166953 0,14283176 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,11166953 0,14275702 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,1137164 0,14529769 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,11585012 0,1479466 ! protein localization in nucleus GO:0034504 192 89 1,000 0,11585012 0,1478693 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,11749571 0,1498914 ! positive regulation of translation GO:0045727 31 19 0,000 0,11749571 0,14981316 ! negative regulation of defense response GO:0031348 27 19 0,000 0,11749571 0,14973501 ! neuron maturation GO:0042551 46 19 0,000 0,11749571 0,14965695 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,11749571 0,14957896 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,11749571 0,14950105 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,11749571 0,14942323 ! inositol metabolic process GO:0006020 33 19 0,000 0,11749571 0,14934549 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,11749571 0,14926782 ! memory GO:0007613 34 19 0,000 0,11749571 0,14919024 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,11749571 0,14911274 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,11749571 0,14903532 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,11749571 0,14895798 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,11749571 0,14888072 ! cerebral cortex development GO:0021987 40 19 0,000 0,11749571 0,14880354 ! heme metabolic process GO:0042168 40 19 0,000 0,11749571 0,14872644 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,11749571 0,14864942 ! response to fungus GO:0009620 26 19 0,000 0,11749571 0,14857248 ! peptide cross-linking GO:0018149 39 19 0,000 0,11749571 0,14849561 ! protein export from nucleus GO:0006611 40 19 0,000 0,11749571 0,14841883 ! heart process GO:0003015 32 19 0,000 0,11749571 0,14834213 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,11749571 0,14826551 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,11749571 0,14818896 ! visual learning GO:0008542 38 19 0,000 0,11749571 0,1481125 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,11749571 0,14803611 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,11749571 0,14795981 ! vitamin transport GO:0051180 31 19 0,000 0,11749571 0,14788358 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,11749571 0,14780743 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,11749571 0,14773136 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,11749571 0,14765536 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,11749571 0,14757945 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,11749571 0,14750361 ! cilium assembly GO:0042384 38 19 0,000 0,11749571 0,14742785 ! peptide hormone secretion GO:0030072 32 19 0,000 0,11749571 0,14735217 ! response to inorganic substance GO:0010035 173 90 1,000 0,11799402 0,14790117 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,11799402 0,14782533 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,12014788 0,15044658 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 1,000 0,12014788 0,15036951 ! bone development GO:0060348 206 92 1,000 0,12231149 0,15299896 ! protein secretion GO:0009306 45 20 0,000 0,12328385 0,15413635 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,12328385 0,15405751 ! positive regulation of ossification GO:0045778 50 20 0,000 0,12328385 0,15397875 ! skin development GO:0043588 42 20 0,000 0,12328385 0,15390007 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,12328385 0,15382147 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,12328385 0,15374295 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,12328385 0,15366451 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,12328385 0,15358615 ! bile acid metabolic process GO:0008206 34 20 0,000 0,12328385 0,15350787 ! retinoid metabolic process GO:0001523 34 20 0,000 0,12328385 0,15342967 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,12328385 0,15335155 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,12328385 0,1532735 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,12328385 0,15319554 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,12328385 0,15311766 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,12328385 0,15303986 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,12328385 0,15296213 ! peptide secretion GO:0002790 38 20 0,000 0,12328385 0,15288449 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,12328385 0,15280692 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,12328385 0,15272943 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,12328385 0,15265202 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,12328385 0,15257469 ! cell-cell junction organization GO:0045216 43 20 0,000 0,12328385 0,15249744 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,12328385 0,15242026 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,12328385 0,15234316 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,12328385 0,15226615 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,12328385 0,15218921 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,12328385 0,15211234 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,12328385 0,15203556 ! negative regulation of translation GO:0017148 32 20 0,000 0,12328385 0,15195885 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,12448462 0,15336153 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 1,000 0,12448462 0,15328423 ! female pregnancy GO:0007565 166 94 1,000 0,12666705 0,155893 ! sterol metabolic process GO:0016125 166 94 1,000 0,12666705 0,15581451 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,12885858 0,15843056 ! regulation of cell killing GO:0031341 46 21 0,000 0,12903418 0,15856665 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,12903418 0,15848693 ! hormone secretion GO:0046879 39 21 0,000 0,12903418 0,15840729 ! cAMP metabolic process GO:0046058 41 21 0,000 0,12903418 0,15832773 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,12903418 0,15824824 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,12903418 0,15816884 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,12903418 0,15808952 ! smooth muscle contraction GO:0006939 48 21 0,000 0,12903418 0,15801028 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 0,12903418 0,15793111 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,12903418 0,15785203 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,12903418 0,15777302 ! plasma membrane fusion GO:0045026 33 21 0,000 0,12903418 0,1576941 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,12903418 0,15761525 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,12903418 0,15753648 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,12903418 0,15745779 ! sensory perception of pain GO:0019233 33 21 0,000 0,12903418 0,15737918 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,12903418 0,15730065 ! diencephalon development GO:0021536 36 21 0,000 0,12903418 0,1572222 ! collagen fibril organization GO:0030199 62 21 0,000 0,12903418 0,15714382 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,12903418 0,15706552 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,12903418 0,1569873 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,12903418 0,15690916 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,12903418 0,1568311 ! collagen catabolic process GO:0030574 29 21 0,000 0,12903418 0,15675311 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,12903418 0,1566752 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,12903418 0,15659737 ! sperm-egg recognition GO:0035036 23 21 0,000 0,12903418 0,15651961 ! actin filament-based movement GO:0030048 47 21 0,000 0,12903418 0,15644194 ! response to protein stimulus GO:0051789 158 96 1,000 0,13105899 0,15881801 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,13474696 0,16320616 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,13474696 0,16312528 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,13474696 0,16304449 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,13474696 0,16296377 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,13474696 0,16288314 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,13474696 0,16280258 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,13474696 0,16272211 ! vacuolar transport GO:0007034 41 22 0,000 0,13474696 0,16264171 ! central nervous system neuron development GO:0021954 47 22 0,000 0,13474696 0,16256139 ! fucose metabolic process GO:0006004 44 22 0,000 0,13474696 0,16248116 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,13474696 0,162401 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,13474696 0,16232092 ! stem cell differentiation GO:0048863 57 22 0,000 0,13474696 0,16224092 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,13474696 0,162161 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,13474696 0,16208115 ! cytolysis GO:0019835 27 22 0,000 0,13474696 0,16200139 ! vasodilation GO:0042311 40 22 0,000 0,13474696 0,1619217 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,13474696 0,1618421 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,13474696 0,16176257 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,13474696 0,16168311 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,13474696 0,16160374 ! sarcomere organization GO:0045214 32 22 0,000 0,13474696 0,16152445 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,13474696 0,16144523 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,13474696 0,16136609 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,13474696 0,16128703 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,13474696 0,16120804 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,13474696 0,16112913 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,13474696 0,1610503 ! forebrain development GO:0030900 210 98 1,000 0,13548562 0,16185397 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,13548562 0,16177486 ! positive regulation of immune response GO:0050778 175 100 1,000 0,1399453 0,16701825 ! hormone metabolic process GO:0042445 171 100 1,000 0,1399453 0,1669367 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,14042243 0,1674241 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,14042243 0,16734243 ! gluconeogenesis GO:0006094 38 23 0,000 0,14042243 0,16726084 ! glycerol metabolic process GO:0006071 40 23 0,000 0,14042243 0,16717933 ! viral genome replication GO:0019079 44 23 0,000 0,14042243 0,1670979 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,14042243 0,16701655 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,14042243 0,16693527 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,14042243 0,16685408 ! axis specification GO:0009798 43 23 0,000 0,14042243 0,16677296 ! visual behavior GO:0007632 46 23 0,000 0,14042243 0,16669193 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,14042243 0,16661097 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,14042243 0,16653009 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,14042243 0,16644929 ! peroxisome organization GO:0007031 43 23 0,000 0,14042243 0,16636857 ! lysosome organization GO:0007040 47 23 0,000 0,14042243 0,16628792 ! vesicle targeting GO:0006903 49 23 0,000 0,14042243 0,16620736 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,14042243 0,16612687 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,14042243 0,16604646 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,14042243 0,16596613 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,14042243 0,16588587 ! fatty acid transport GO:0015908 47 23 0,000 0,14042243 0,1658057 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,14042243 0,1657256 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,14042243 0,16564558 ! hormone transport GO:0009914 41 23 0,000 0,14042243 0,16556563 ! cell-cell recognition GO:0009988 28 23 0,000 0,14042243 0,16548576 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,14042243 0,16540597 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,14042243 0,16532626 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,14042243 0,16524662 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,14606083 0,17179904 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,14606083 0,17171636 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,14606083 0,17163377 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,14606083 0,17155125 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,14606083 0,17146881 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,14606083 0,17138645 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,14606083 0,17130418 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,14606083 0,17122198 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,14606083 0,17113985 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,14606083 0,17105781 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,14606083 0,17097585 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,14606083 0,17089396 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,14606083 0,17081216 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,14606083 0,17073043 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,14606083 0,17064878 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,14606083 0,17056721 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,14606083 0,17048571 ! membrane depolarization GO:0051899 45 24 0,000 0,14606083 0,1704043 ! pallium development GO:0021543 56 24 0,000 0,14606083 0,17032296 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,14606083 0,1702417 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,14606083 0,17016051 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,14606083 0,17007941 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,14606083 0,16999838 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,14606083 0,16991743 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,14606083 0,16983655 GO:0033013|tetrapyrrole metabolic process, ! regulation of amine transport GO:0051952 41 24 0,000 0,14606083 0,16975576 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,1516624 0,17618223 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,1516624 0,1760985 ! leukocyte adhesion GO:0007159 55 25 0,000 0,1516624 0,17601484 ! phototransduction GO:0007602 37 25 0,000 0,1516624 0,17593126 ! keratinization GO:0031424 37 25 0,000 0,1516624 0,17584776 ! vacuole organization GO:0007033 49 25 0,000 0,1516624 0,17576434 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,1516624 0,175681 ! chromosome condensation GO:0030261 48 25 0,000 0,1516624 0,17559774 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,1516624 0,17551456 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,1516624 0,17543146 ! interaction with host GO:0051701 66 25 0,000 0,1516624 0,17534843 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,1516624 0,17526549 ! immunoglobulin production GO:0002377 62 25 0,000 0,1516624 0,17518262 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,1516624 0,17509983 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,1516624 0,17501712 ! liver development GO:0001889 55 25 0,000 0,1516624 0,17493448 ! initiation of viral infection GO:0019059 60 26 0,000 0,15722738 0,18126781 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,15722738 0,18118231 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,15722738 0,18109688 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,15722738 0,18101154 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,15722738 0,18092628 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,15722738 0,1808411 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,15722738 0,180756 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,15722738 0,18067097 ! digestive system process GO:0022600 49 26 0,000 0,15722738 0,18058603 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,15722738 0,18050117 ! osteoblast differentiation GO:0001649 63 26 0,000 0,15722738 0,18041639 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,15722738 0,18033169 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,15722738 0,18024706 ! pentose metabolic process GO:0019321 43 26 0,000 0,15722738 0,18016252 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,15722738 0,18007806 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,15722738 0,17999367 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,15722738 0,17990936 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,15722738 0,17982514 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,15722738 0,17974099 ! blastocyst development GO:0001824 50 26 0,000 0,15722738 0,17965692 ! telomere organization GO:0032200 46 26 0,000 0,15722738 0,17957293 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,15722738 0,17948902 ! alditol metabolic process GO:0019400 44 26 0,000 0,15722738 0,17940518 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,15722738 0,17932143 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,15722738 0,17923775 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,16275602 0,1854538 ! embryonic pattern specification GO:0009880 49 27 0,000 0,16275602 0,18536734 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,16275602 0,18528096 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,16275602 0,18519466 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,16275602 0,18510845 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,16275602 0,18502231 ! iron ion transport GO:0006826 65 27 0,000 0,16275602 0,18493625 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,16275602 0,18485028 ! superoxide metabolic process GO:0006801 41 27 0,000 0,16275602 0,18476438 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,16275602 0,18467856 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,16275602 0,18459283 ! neuron fate commitment GO:0048663 52 28 0,000 0,16824854 0,19073372 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,16824854 0,19064526 ! vesicle docking GO:0048278 55 28 0,000 0,16824854 0,19055687 ! circadian rhythm GO:0007623 56 28 0,000 0,16824854 0,19046857 ! fat cell differentiation GO:0045444 57 28 0,000 0,16824854 0,19038035 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,16824854 0,19029221 ! sperm motility GO:0030317 37 28 0,000 0,16824854 0,19020415 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,16824854 0,19011618 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,16824854 0,19002828 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,16824854 0,18994047 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,16824854 0,18985274 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,16824854 0,18976508 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,16824854 0,18967751 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,16824854 0,18959002 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,16824854 0,18950262 ! lipid oxidation GO:0034440 48 28 0,000 0,16824854 0,18941529 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,16824854 0,18932804 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,16824854 0,18924087 ! translational initiation GO:0006413 66 29 0,000 0,17370518 0,19528843 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,17370518 0,1951986 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,17370518 0,19510885 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,17370518 0,19501919 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,17370518 0,1949296 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,17370518 0,19484011 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,17370518 0,19475069 ! synaptogenesis GO:0007416 46 29 0,000 0,17370518 0,19466135 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,17370518 0,1945721 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,17370518 0,19448293 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,17370518 0,19439384 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,17912617 0,2003687 ! phenol metabolic process GO:0018958 56 30 0,000 0,17912617 0,200277 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,17912617 0,20018538 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,17912617 0,20009385 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,17912617 0,2000024 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,17912617 0,19991103 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,17912617 0,19981975 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,17912617 0,19972855 ! acute-phase response GO:0006953 50 30 0,000 0,17912617 0,19963743 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,17912617 0,19954639 ! myofibril assembly GO:0030239 50 30 0,000 0,17912617 0,19945544 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,17912617 0,19936458 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,17912617 0,19927379 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,17912617 0,19918309 ! cell fate determination GO:0001709 64 30 0,000 0,17912617 0,19909247 ! phospholipid transport GO:0015914 65 30 0,000 0,17912617 0,19900193 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,17912617 0,19891147 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,17912617 0,1988211 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,18451176 0,20470582 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,18451176 0,2046129 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,18451176 0,20452007 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,18451176 0,20442731 ! regulation of innate immune response GO:0045088 57 31 0,000 0,18451176 0,20433464 ! peptide transport GO:0015833 60 31 0,000 0,18451176 0,20424206 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,18451176 0,20414956 ! detection of light stimulus GO:0009583 44 31 0,000 0,18451176 0,20405714 ! natural killer cell activation GO:0030101 50 31 0,000 0,18451176 0,20396481 ! cofactor catabolic process GO:0051187 54 31 0,000 0,18451176 0,20387256 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,18451176 0,20378039 ! eye morphogenesis GO:0048592 65 31 0,000 0,18451176 0,20368831 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,18451176 0,20359631 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,18986216 0,20940553 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,18986216 0,20931103 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,18986216 0,20921662 ! muscle cell development GO:0055001 52 32 0,000 0,18986216 0,2091223 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,18986216 0,20902805 ! BMP signaling pathway GO:0030509 71 32 0,000 0,18986216 0,2089339 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,18986216 0,20883982 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,18986216 0,20874584 ! gene silencing GO:0016458 71 32 0,000 0,18986216 0,20865193 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,1951776 0,21439698 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,1951776 0,21430062 GO:0055092|sterol homeostasis, ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,1951776 0,21420435 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,1951776 0,21410817 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,1951776 0,21401207 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,1951776 0,21391605 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,1951776 0,21382013 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,1951776 0,21372429 ! cholesterol transport GO:0030301 62 34 0,000 0,20045832 0,21940846 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,20045832 0,2193102 ! spliceosome assembly GO:0000245 75 34 0,000 0,20045832 0,21921203 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,20045832 0,21911395 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,20045832 0,21901596 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,20045832 0,21891805 ! adult locomotory behavior GO:0008344 62 34 0,000 0,20045832 0,21882023 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,20045832 0,2187225 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,20570454 0,22434651 ! negative regulation of secretion GO:0051048 68 35 0,000 0,20570454 0,2242464 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,20570454 0,22414638 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,20570454 0,22404645 ! membrane docking GO:0022406 69 35 0,000 0,20570454 0,22394661 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,20570454 0,22384686 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,20570454 0,22374719 ! ceramide metabolic process GO:0006672 72 35 0,000 0,20570454 0,22364762 ! telencephalon development GO:0021537 81 35 0,000 0,20570454 0,22354813 ! sterol transport GO:0015918 63 35 0,000 0,20570454 0,22344873 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,20570454 0,22334942 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,20570454 0,2232502 ! vesicle localization GO:0051648 70 35 0,000 0,20570454 0,22315106 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,21091648 0,22870349 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,21091648 0,22860203 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,21091648 0,22850065 ! protein targeting to membrane GO:0006612 75 36 0,000 0,21091648 0,22839936 ! regulation of proteolysis GO:0030162 77 36 0,000 0,21091648 0,22829817 ! aerobic respiration GO:0009060 56 36 0,000 0,21091648 0,22819706 ! cytokine production GO:0001816 68 36 0,000 0,21091648 0,22809605 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,21091648 0,22799512 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,21091648 0,22789428 ! sister chromatid segregation GO:0000819 65 37 0,000 0,21609437 0,23338574 ! actomyosin structure organization GO:0031032 68 37 0,000 0,21609437 0,23328261 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,21609437 0,23317957 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,21609437 0,23307662 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,22123843 0,23851963 ! meiosis I GO:0007127 74 38 0,000 0,22123843 0,23841441 ! organic anion transport GO:0015711 82 38 0,000 0,22123843 0,23830929 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,22123843 0,23820427 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,22123843 0,23809933 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,22123843 0,23799449 ! spermatid development GO:0007286 69 38 0,000 0,22123843 0,23788974 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,22634887 0,24327774 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,22634887 0,24317075 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,22634887 0,24306387 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,22634887 0,24295707 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,22634887 0,24285037 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,22634887 0,24274376 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,23142592 0,24807965 ! learning GO:0007612 82 40 0,000 0,23142592 0,24797085 ! lipid homeostasis GO:0055088 75 40 0,000 0,23142592 0,24786214 ! mismatch repair GO:0006298 58 40 0,000 0,23142592 0,24775352 ! RNA export from nucleus GO:0006405 61 41 0,000 0,2364698 0,25304237 ! mRNA catabolic process GO:0006402 79 41 0,000 0,2364698 0,25293158 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,2364698 0,25282088 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,2364698 0,25271029 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,2364698 0,25259979 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,2364698 0,25248939 ! feeding behavior GO:0007631 69 41 0,000 0,2364698 0,25237908 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,2364698 0,25226887 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,2364698 0,25215876 ! RNA modification GO:0009451 64 41 0,000 0,2364698 0,25204874 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,24148071 0,25727753 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,24148071 0,25716538 ! regulation of protein secretion GO:0050708 77 42 0,000 0,24148071 0,25705333 ! cytokinesis GO:0000910 84 42 0,000 0,24148071 0,25694137 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,24645888 0,2621241 ! regulation of tube size GO:0035150 76 43 0,000 0,24645888 0,26201003 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,24645888 0,26189607 ! glucose transport GO:0015758 66 43 0,000 0,24645888 0,2617822 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,24645888 0,26166843 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,24645888 0,26155476 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,24645888 0,26144119 ! ion transmembrane transport GO:0034220 79 43 0,000 0,24645888 0,26132772 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,25140452 0,26645607 ! hexose transport GO:0008645 68 44 0,000 0,25140452 0,26634052 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 0,000 0,25140452 0,26622508 ! phagocytosis GO:0006909 105 44 0,000 0,25140452 0,26610973 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,25140452 0,26599448 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,25631784 0,27107553 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,25631784 0,27095824 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,25631784 0,27084104 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,25631784 0,27072394 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,25631784 0,27060695 ! polyol metabolic process GO:0019751 77 45 0,000 0,25631784 0,27049006 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,26119905 0,27552214 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,26119905 0,27540322 ! glycolysis GO:0006096 71 46 0,000 0,26119905 0,27528441 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,26119905 0,2751657 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,26119905 0,2750471 ! positive regulation of cell cycle GO:0045787 96 48 0,000 0,27086596 0,28510364 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,27086596 0,28498085 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,27086596 0,28485818 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,27086596 0,2847356 ! response to calcium ion GO:0051592 94 49 0,000 0,27565208 0,28964217 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,27565208 0,28951765 ! JNK cascade GO:0007254 106 49 0,000 0,27565208 0,28939323 ! protein homooligomerization GO:0051260 84 49 0,000 0,27565208 0,28926892 ! regulation of ion transport GO:0043269 86 50 0,000 0,28040693 0,2941323 ! endocrine system development GO:0035270 109 50 0,000 0,28040693 0,29400606 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,28040693 0,29387993 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,28040693 0,29375391 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,28040693 0,293628 ! viral infectious cycle GO:0019058 104 51 0,000 0,28513069 0,29844656 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,28513069 0,29831874 ! Notch signaling pathway GO:0007219 111 52 0,000 0,28982357 0,30309888 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,28982357 0,30296918 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,28982357 0,3028396 ! excretion GO:0007588 87 52 0,000 0,28982357 0,30271013 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,28982357 0,30258076 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,28982357 0,30245151 ! amino acid activation GO:0043038 98 52 0,000 0,28982357 0,30232237 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,29448578 0,30705453 ! regulation of translational initiation GO:0006446 87 54 0,000 0,29911751 0,31175089 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,29911751 0,31161795 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,29911751 0,31148512 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,29911751 0,3113524 ! membrane fusion GO:0006944 122 54 0,000 0,29911751 0,3112198 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,29911751 0,31108731 ! RNA catabolic process GO:0006401 103 55 0,000 0,30371897 0,31573848 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,30371897 0,31560418 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,30371897 0,31547 ! cell recognition GO:0008037 98 55 0,000 0,30371897 0,31533593 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,30371897 0,31520197 ! glucose catabolic process GO:0006007 88 56 0,000 0,30829034 0,31981032 ! chloride transport GO:0006821 102 57 0,000 0,31283183 0,32438377 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,31283183 0,32424614 ! regulation of actin filament length GO:0030832 118 58 0,000 0,31734363 0,32878307 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,31734363 0,3286437 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,31734363 0,32850444 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,31734363 0,3283653 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,31734363 0,32822628 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,31734363 0,32808738 ! nuclear export GO:0051168 110 59 0,000 0,32182593 0,33258069 ! establishment of organelle localization GO:0051656 122 59 0,000 0,32182593 0,33244006 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,32627892 0,33689747 ! regulation of endocytosis GO:0030100 104 60 0,000 0,32627892 0,33675514 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,32627892 0,33661293 ! adult behavior GO:0030534 104 60 0,000 0,32627892 0,33647084 ! positive regulation of secretion GO:0051047 110 61 0,000 0,33070281 0,34088901 ! regulation of cellular component size GO:0032535 125 61 0,000 0,33070281 0,34074524 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,33070281 0,34060158 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,33070281 0,34045805 ! camera-type eye development GO:0043010 126 61 0,000 0,33070281 0,34031464 ! proton transport GO:0015992 117 61 0,000 0,33070281 0,34017135 ! viral reproductive process GO:0022415 132 62 0,000 0,33509776 0,34454707 ! tRNA processing GO:0008033 102 62 0,000 0,33509776 0,34440212 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,33946398 0,34874285 ! regulation of mitosis GO:0007088 112 63 0,000 0,33946398 0,34859626 GO:0051783|regulation of nuclear division, ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,33946398 0,34844979 ! hydrogen transport GO:0006818 121 64 0,000 0,34380165 0,35275407 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,34380165 0,35260598 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,34811096 0,35687582 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,35239209 0,3611132 ! chromosome segregation GO:0007059 127 67 0,000 0,35664522 0,36531835 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,35664522 0,36516525 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,35664522 0,36501226 ! hexose catabolic process GO:0019320 113 68 0,000 0,36087054 0,36918205 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,36087054 0,36902751 ! viral reproduction GO:0016032 142 68 0,000 0,36087054 0,36887311 ! regulation of lipase activity GO:0060191 137 68 0,000 0,36087054 0,36871883 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,36506823 0,37285187 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,36506823 0,37269606 ! cell redox homeostasis GO:0045454 114 70 0,000 0,36923846 0,37679598 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,37338143 0,38086464 ! carbohydrate transport GO:0008643 114 72 0,000 0,37749729 0,38490229 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,37749729 0,38474171 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,37749729 0,38458127 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,38158624 0,3885849 ! regulation of immune effector process GO:0002697 156 73 0,000 0,38158624 0,38842299 ! organelle localization GO:0051640 155 74 0,000 0,38564844 0,39239448 ! transition metal ion transport GO:0000041 143 75 0,000 0,38968408 0,39633564 ! eye development GO:0001654 155 75 0,000 0,38968408 0,3961707 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,39369331 0,40008018 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,39369331 0,39991383 ! regulation of blood pressure GO:0008217 134 76 0,000 0,39369331 0,39974761 ! amine catabolic process GO:0009310 136 77 0,000 0,39767632 0,40362412 ! neurotransmitter transport GO:0006836 142 77 0,000 0,39767632 0,4034565 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,39767632 0,40328902 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,39767632 0,40312168 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,39767632 0,40295448 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,40163328 0,40679523 ! antigen processing and presentation GO:0019882 117 78 0,000 0,40163328 0,40662665 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,40556435 0,4104365 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,40556435 0,41026655 ! muscle cell differentiation GO:0042692 178 81 0,000 0,41334952 0,41796891 ! exocytosis GO:0006887 153 83 0,000 0,42103316 0,42556227 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,42103316 0,42538627 ! inorganic anion transport GO:0015698 156 83 0,000 0,42103316 0,42521042 ! digestion GO:0007586 130 84 0,000 0,42483732 0,42887503 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,42861659 0,43251149 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,43610111 0,43988233 ! alcohol catabolic process GO:0046164 142 87 0,000 0,43610111 0,43970079 ! nucleosome assembly GO:0006334 126 87 0,000 0,43610111 0,43951939 ! cellular respiration GO:0045333 143 88 0,000 0,43980668 0,44307122 ! amine biosynthetic process GO:0009309 146 88 0,000 0,43980668 0,44288859 ! sensory perception of smell GO:0007608 117 88 0,000 0,43980668 0,44270611 ! chromatin assembly GO:0031497 128 88 0,000 0,43980668 0,44252377 ! cellular defense response GO:0006968 123 89 0,000 0,443488 0,44604413 ! regulation of neurological system process GO:0031644 175 89 0,000 0,443488 0,44586057 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,44714524 0,44935246 ! response to unfolded protein GO:0006986 139 90 0,000 0,44714524 0,44916769 ! defense response to bacterium GO:0042742 112 91 0,000 0,45077854 0,45263131 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,45438807 0,45606823 ! vitamin metabolic process GO:0006766 153 93 0,000 0,45797398 0,45947862 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,46153642 0,46286267 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,46153642 0,46267274 ! nucleosome organization GO:0034728 143 95 0,000 0,46507555 0,46602935 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,46507555 0,46583828 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,46507555 0,46564736 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,46507555 0,4654566 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,47208446 0,47227778 ! mRNA transport GO:0051028 185 100 0,000 0,48242675 0,48242675