pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6902-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cellular response to hormone stimulus GO:0032870 182 85 10,000 8,591E-13 2,099E-09 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 7,000 1,315E-12 1,606E-09 ! positive regulation of MAP kinase activity GO:0043406 174 93 10,000 2,368E-12 1,928E-09 ! insulin receptor signaling pathway GO:0008286 66 27 6,000 7,508E-11 4,585E-08 ! organ growth GO:0035265 15 7 4,000 7,534E-11 3,681E-08 ! positive regulation of cell migration GO:0030335 137 58 7,000 7,1E-10 2,891E-07 ! cellular response to insulin stimulus GO:0032869 85 38 6,000 1,017E-09 3,548E-07 ! response to peptide hormone stimulus GO:0043434 129 64 7,000 1,596E-09 4,875E-07 ! positive regulation of cell motion GO:0051272 157 65 7,000 1,812E-09 4,92E-07 ! activation of MAPK activity GO:0000187 124 67 7,000 2,321E-09 5,671E-07 ! response to insulin stimulus GO:0032868 98 47 6,000 4,87E-09 1,082E-06 ! response to hypoxia GO:0001666 178 81 7,000 1,076E-08 2,191E-06 ! response to oxygen levels GO:0070482 183 83 7,000 1,308E-08 2,458E-06 ! negative regulation of transport GO:0051051 164 85 7,000 1,582E-08 2,76E-06 ! negative regulation of hormone secretion GO:0046888 26 17 4,000 2,128E-08 3,466E-06 ! regulation of protein export from nucleus GO:0046825 10 7 3,000 2,456E-08 3,75E-06 ! negative regulation of peptide secretion GO:0002792 10 7 3,000 2,456E-08 3,53E-06 GO:0046676|negative regulation of insulin secretion, ! negative regulation of secretion GO:0051048 68 35 5,000 2,624E-08 3,561E-06 ! positive regulation of hormone secretion GO:0046887 35 19 4,000 3,965E-08 5,099E-06 ! DNA integrity checkpoint GO:0031570 82 38 5,000 4,406E-08 5,381E-06 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 3,000 4,892E-08 5,692E-06 ! regulation of growth hormone secretion GO:0060123 16 8 3,000 4,892E-08 5,433E-06 ! induction of positive chemotaxis GO:0050930 17 9 3,000 8,771E-08 9,316E-06 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 3,000 8,771E-08 8,928E-06 ! cell cycle checkpoint GO:0000075 145 71 6,000 9,271E-08 9,059E-06 ! negative regulation of phosphorylation GO:0042326 52 24 4,000 1,419E-07 1,333E-05 ! positive regulation of cell cycle GO:0045787 96 48 5,000 1,876E-07 1,697E-05 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 4,000 2,178E-07 1,9E-05 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of nuclear division GO:0051785 41 26 4,000 2,178E-07 1,835E-05 GO:0045840|positive regulation of mitosis, ! regulation of positive chemotaxis GO:0050926 22 12 3,000 3,404E-07 2,772E-05 GO:0050927|positive regulation of positive chemotaxis, ! regulation of angiogenesis GO:0045765 125 54 5,000 3,847E-07 3,031E-05 ! regulation of multicellular organism growth GO:0040014 90 55 5,000 4,299E-07 3,282E-05 ! regulation of cell cycle process GO:0010564 161 90 6,000 4,793E-07 3,548E-05 ! cell junction assembly GO:0034329 85 31 4,000 5,508E-07 3,958E-05 ! negative regulation of multicellular organismal process GO:0051241 174 95 6,000 6,935E-07 4,841E-05 ! triglyceride metabolic process GO:0006641 46 33 4,000 7,629E-07 5,177E-05 ! regulation of mitosis GO:0007088 112 63 5,000 9,734E-07 6,427E-05 GO:0051783|regulation of nuclear division, ! DNA damage checkpoint GO:0000077 78 35 4,000 1,035E-06 6,652E-05 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 1,377E-06 8,624E-05 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 4,000 1,378E-06 8,415E-05 ! cell junction organization GO:0034330 96 37 4,000 1,378E-06 8,209E-05 ! neutral lipid metabolic process GO:0006638 54 38 4,000 1,58E-06 9,189E-05 GO:0006639|acylglycerol metabolic process, ! neutrophil chemotaxis GO:0030593 29 17 3,000 1,603E-06 9,11E-05 ! negative regulation of blood coagulation GO:0030195 25 17 3,000 1,603E-06 8,903E-05 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 1,674E-06 9,086E-05 ! carbohydrate homeostasis GO:0033500 59 39 4,000 1,805E-06 9,584E-05 GO:0042593|glucose homeostasis, ! cell-substrate junction assembly GO:0007044 56 18 3,000 2,053E-06 1,067E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 3,000 2,053E-06 1,045E-04 ! glycerol ether metabolic process GO:0006662 57 40 4,000 2,054E-06 1,024E-04 ! regulation of hormone secretion GO:0046883 69 41 4,000 2,329E-06 1,138E-04 ! organic ether metabolic process GO:0018904 59 42 4,000 2,633E-06 1,261E-04 ! neural nucleus development GO:0048857 19 6 2,000 2,743E-06 1,289E-04 ! negative regulation of coagulation GO:0050819 30 20 3,000 3,225E-06 1,486E-04 ! branching morphogenesis of a tube GO:0048754 102 45 4,000 3,734E-06 1,689E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 3,734E-06 1,658E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 3,000 3,967E-06 1,731E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 4,171E-06 1,788E-04 ! positive regulation of phosphorylation GO:0042327 149 81 5,000 4,303E-06 1,812E-04 ! wound healing, spreading of epidermal cells GO:0035313 16 7 2,000 4,781E-06 1,98E-04 ! fibrinolysis GO:0042730 11 7 2,000 4,781E-06 1,947E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 4,781E-06 1,915E-04 ! positive regulation of locomotion GO:0040017 44 22 3,000 4,829E-06 1,903E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of phosphorus metabolic process GO:0010562 156 83 5,000 4,961E-06 1,924E-04 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of chemotaxis GO:0050920 45 23 3,000 5,822E-06 2,222E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 7,621E-06 2,864E-04 ! positive regulation of endothelial cell migration GO:0010595 19 8 2,000 7,621E-06 2,821E-04 ! morphogenesis of a branching structure GO:0001763 116 52 4,000 7,712E-06 2,812E-04 ! regulation of insulin secretion GO:0050796 42 25 3,000 8,25E-06 2,964E-04 ! regulation of behavior GO:0050795 48 25 3,000 8,25E-06 2,921E-04 ! regulation of blood coagulation GO:0030193 46 26 3,000 9,71E-06 3,389E-04 ! response to UV GO:0009411 120 55 4,000 1,019E-05 3,507E-04 ! regulation of membrane potential GO:0042391 179 94 5,000 1,021E-05 3,463E-04 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 2,000 1,139E-05 3,811E-04 GO:0010469|regulation of receptor activity, ! middle ear morphogenesis GO:0042474 14 9 2,000 1,139E-05 3,759E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,139E-05 3,709E-04 ! regulation of protein localization GO:0032880 188 97 5,000 1,223E-05 3,931E-04 ! positive regulation of organelle organization GO:0010638 108 58 4,000 1,326E-05 4,206E-04 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 3,000 1,524E-05 4,773E-04 ! regulation of peptide secretion GO:0002791 52 29 3,000 1,524E-05 4,712E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,621E-05 4,949E-04 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 1,621E-05 4,888E-04 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 1,621E-05 4,828E-04 ! positive regulation of secretion GO:0051047 110 61 4,000 1,7E-05 5,003E-04 ! regulation of heart contraction GO:0008016 123 61 4,000 1,7E-05 4,943E-04 ! regulation of coagulation GO:0050818 52 30 3,000 1,751E-05 5,033E-04 ! DNA damage response, signal transduction GO:0042770 136 62 4,000 1,841E-05 5,23E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 2,22E-05 6,233E-04 ! negative regulation of glucose import GO:0046325 18 11 2,000 2,22E-05 6,162E-04 GO:0010829|negative regulation of glucose transport, ! multicellular organism reproduction GO:0032504 123 65 4,000 2,32E-05 6,369E-04 GO:0048609|reproductive process in a multicellular organism, ! leukocyte chemotaxis GO:0030595 55 33 3,000 2,583E-05 7,012E-04 GO:0060326|cell chemotaxis, ! negative regulation of cell growth GO:0030308 142 67 4,000 2,69E-05 7,223E-04 ! regulation of B cell proliferation GO:0030888 22 12 2,000 2,948E-05 7,829E-04 ! focal adhesion formation GO:0048041 37 12 2,000 2,948E-05 7,745E-04 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 2,948E-05 7,662E-04 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of cell size GO:0045792 144 69 4,000 3,105E-05 7,984E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 4,000 3,105E-05 7,9E-04 ! negative regulation of kinase activity GO:0033673 145 70 4,000 3,329E-05 8,385E-04 ! negative regulation of transferase activity GO:0051348 155 74 4,000 4,357E-05 1,086E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 4,841E-05 1,195E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 2,000 4,841E-05 1,183E-03 GO:0060675|ureteric bud morphogenesis, ! cell-matrix adhesion GO:0007160 181 76 4,000 4,956E-05 1,199E-03 ! nucleus organization GO:0006997 73 40 3,000 5,607E-05 1,343E-03 ! negative regulation of bone remodeling GO:0046851 34 15 2,000 6,028E-05 1,43E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 6,028E-05 1,416E-03 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 6,812E-05 1,585E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 7,137E-05 1,645E-03 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 2,000 7,39E-05 1,687E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 2,000 7,39E-05 1,672E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 7,39E-05 1,656E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! hormone-mediated signaling GO:0009755 84 43 3,000 7,48E-05 1,661E-03 ! positive regulation of response to external stimulus GO:0032103 88 44 3,000 8,195E-05 1,804E-03 ! negative regulation of growth GO:0045926 168 85 4,000 8,472E-05 1,848E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 8,94E-05 1,933E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 8,94E-05 1,916E-03 ! regulation of protein transport GO:0051223 165 87 4,000 9,464E-05 2,011E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 9,771E-05 2,058E-03 ! leukocyte migration GO:0050900 75 46 3,000 9,771E-05 2,04E-03 ! negative regulation of cell migration GO:0030336 122 46 3,000 9,771E-05 2,023E-03 ! tube morphogenesis GO:0035239 194 89 4,000 1,054E-04 2,164E-03 ! response to retinoic acid GO:0032526 31 18 2,000 1,069E-04 2,176E-03 ! defense response to virus GO:0051607 43 18 2,000 1,069E-04 2,158E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 1,253E-04 2,51E-03 ! response to vitamin A GO:0033189 32 19 2,000 1,264E-04 2,511E-03 ! regulation of endothelial cell migration GO:0010594 45 19 2,000 1,264E-04 2,491E-03 ! response to vitamin GO:0033273 36 20 2,000 1,482E-04 2,896E-03 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 1,482E-04 2,873E-03 ! regulation of glucose import GO:0046324 30 20 2,000 1,482E-04 2,85E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 1,482E-04 2,828E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 1,661E-04 3,146E-03 ! positive regulation of growth GO:0045927 96 53 3,000 1,704E-04 3,203E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 1,704E-04 3,178E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 3,000 1,704E-04 3,154E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 1,722E-04 3,163E-03 ! plasma membrane fusion GO:0045026 33 21 2,000 1,722E-04 3,139E-03 ! regulation of vasoconstriction GO:0019229 40 21 2,000 1,722E-04 3,116E-03 ! negative regulation of angiogenesis GO:0016525 49 21 2,000 1,722E-04 3,093E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 1,722E-04 3,071E-03 ! hormone metabolic process GO:0042445 171 100 4,000 1,826E-04 3,233E-03 ! activation of phospholipase C activity GO:0007202 110 54 3,000 1,833E-04 3,222E-03 GO:0010863|positive regulation of phospholipase C activity, ! regulation of muscle contraction GO:0006937 94 54 3,000 1,833E-04 3,199E-03 ! positive regulation of phospholipase activity GO:0010518 111 55 3,000 1,969E-04 3,412E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 1,969E-04 3,388E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 1,986E-04 3,393E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 1,986E-04 3,37E-03 ! ureteric bud development GO:0001657 50 22 2,000 1,986E-04 3,346E-03 ! renal system process GO:0003014 42 22 2,000 1,986E-04 3,323E-03 ! response to cytokine stimulus GO:0034097 69 22 2,000 1,986E-04 3,301E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 3,000 2,262E-04 3,734E-03 ! regulation of phospholipase activity GO:0010517 113 57 3,000 2,262E-04 3,709E-03 ! regulation of intracellular transport GO:0032386 108 57 3,000 2,262E-04 3,684E-03 ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 2,275E-04 3,681E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 2,275E-04 3,657E-03 ! positive regulation of lipase activity GO:0060193 115 58 3,000 2,42E-04 3,864E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 2,59E-04 4,109E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 2,59E-04 4,083E-03 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 1,000 2,667E-04 4,176E-03 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 1,000 2,667E-04 4,15E-03 GO:0045844|positive regulation of striated muscle development, ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,667E-04 4,123E-03 ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 2,667E-04 4,097E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 2,667E-04 4,072E-03 ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 1,000 2,667E-04 4,047E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,667E-04 4,022E-03 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 1,000 2,667E-04 3,997E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 2,667E-04 3,973E-03 ! microvillus organization GO:0032528 8 5 1,000 2,667E-04 3,948E-03 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 1,000 2,667E-04 3,925E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 1,000 2,667E-04 3,901E-03 ! muscle cell migration GO:0014812 8 5 1,000 2,667E-04 3,878E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 2,667E-04 3,855E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,667E-04 3,832E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,667E-04 3,81E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,667E-04 3,788E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,667E-04 3,766E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,667E-04 3,744E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 2,667E-04 3,723E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,667E-04 3,702E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,667E-04 3,681E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 2,667E-04 3,66E-03 ! stem cell division GO:0017145 11 5 1,000 2,667E-04 3,64E-03 GO:0048103|somatic stem cell division, ! myelination GO:0042552 50 26 2,000 3,302E-04 4,482E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 3,302E-04 4,457E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 3,537E-04 4,748E-03 ! mitochondrial membrane organization GO:0007006 60 27 2,000 3,701E-04 4,941E-03 ! response to toxin GO:0009636 49 27 2,000 3,701E-04 4,914E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 3,701E-04 4,887E-03 ! ear development GO:0043583 114 66 3,000 3,98E-04 5,227E-03 ! toxin metabolic process GO:0009404 11 6 1,000 3,986E-04 5,208E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 1,000 3,986E-04 5,18E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! vascular smooth muscle contraction GO:0014829 13 6 1,000 3,986E-04 5,153E-03 ! positive regulation of muscle hypertrophy GO:0014742 10 6 1,000 3,986E-04 5,126E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! neuron apoptosis GO:0051402 15 6 1,000 3,986E-04 5,099E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 3,986E-04 5,072E-03 GO:0051653|spindle localization, ! purine base biosynthetic process GO:0009113 17 6 1,000 3,986E-04 5,046E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 3,986E-04 5,02E-03 ! progesterone metabolic process GO:0042448 12 6 1,000 3,986E-04 4,994E-03 ! triglyceride catabolic process GO:0019433 10 6 1,000 3,986E-04 4,969E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 3,986E-04 4,944E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 4,129E-04 5,095E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 4,129E-04 5,069E-03 ! regulation of lipase activity GO:0060191 137 68 3,000 4,461E-04 5,449E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 5,078E-04 6,172E-03 ! regulation of B cell activation GO:0050864 55 30 2,000 5,078E-04 6,142E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 5,562E-04 6,694E-03 ! mRNA stabilization GO:0048255 18 7 1,000 5,562E-04 6,661E-03 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 5,562E-04 6,628E-03 ! positive regulation of heart rate GO:0010460 11 7 1,000 5,562E-04 6,596E-03 ! regulation of granule cell precursor proliferation GO:0021936 12 7 1,000 5,562E-04 6,564E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! phasic smooth muscle contraction GO:0014821 12 7 1,000 5,562E-04 6,533E-03 ! maintenance of protein location in nucleus GO:0051457 19 7 1,000 5,562E-04 6,501E-03 ! glycerol ether catabolic process GO:0044269 12 7 1,000 5,562E-04 6,47E-03 GO:0046464|acylglycerol catabolic process, ! male sex determination GO:0030238 15 7 1,000 5,562E-04 6,44E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 5,562E-04 6,409E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 5,562E-04 6,379E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 5,562E-04 6,349E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 5,562E-04 6,32E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 5,562E-04 6,291E-03 ! diuresis GO:0030146 12 7 1,000 5,562E-04 6,262E-03 GO:0030147|natriuresis, ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 5,562E-04 6,233E-03 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 1,000 5,562E-04 6,205E-03 ! ensheathment of neurons GO:0007272 64 31 2,000 5,601E-04 6,22E-03 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 5,601E-04 6,192E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 3,000 6,152E-04 6,77E-03 ! metanephros development GO:0001656 81 32 2,000 6,157E-04 6,745E-03 ! hindbrain development GO:0030902 65 32 2,000 6,157E-04 6,715E-03 ! phosphoinositide-mediated signaling GO:0048015 141 75 3,000 6,472E-04 7,027E-03 ! response to ionizing radiation GO:0010212 74 33 2,000 6,747E-04 7,293E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 7,371E-04 7,933E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 7,391E-04 7,919E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 7,391E-04 7,884E-03 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 7,391E-04 7,85E-03 ! succinate metabolic process GO:0006105 17 8 1,000 7,391E-04 7,816E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 7,391E-04 7,782E-03 ! glycerolipid catabolic process GO:0046503 14 8 1,000 7,391E-04 7,749E-03 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 7,391E-04 7,716E-03 ! pigment granule organization GO:0048753 17 8 1,000 7,391E-04 7,683E-03 ! regulation of pigmentation during development GO:0048070 25 8 1,000 7,391E-04 7,65E-03 ! melanin metabolic process GO:0006582 17 8 1,000 7,391E-04 7,618E-03 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 1,000 7,391E-04 7,586E-03 ! regulation of muscle hypertrophy GO:0014743 12 8 1,000 7,391E-04 7,554E-03 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 7,391E-04 7,523E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 7,391E-04 7,492E-03 ! response to UV-B GO:0010224 17 8 1,000 7,391E-04 7,461E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 7,391E-04 7,43E-03 ! positive regulation of smooth muscle contraction GO:0045987 15 8 1,000 7,391E-04 7,4E-03 ! negative regulation of DNA replication initiation GO:0032297 10 8 1,000 7,391E-04 7,369E-03 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 7,391E-04 7,339E-03 ! blood coagulation GO:0007596 151 79 3,000 7,872E-04 7,786E-03 GO:0050817|coagulation, ! regulation of striated muscle tissue development GO:0016202 81 35 2,000 8,032E-04 7,912E-03 ! calcium-mediated signaling GO:0019722 67 35 2,000 8,032E-04 7,88E-03 ! activation of protein kinase activity GO:0032147 170 80 3,000 8,253E-04 8,065E-03 ! regulation of muscle development GO:0048634 82 36 2,000 8,728E-04 8,495E-03 ! mitotic sister chromatid segregation GO:0000070 63 36 2,000 8,728E-04 8,462E-03 ! sister chromatid segregation GO:0000819 65 37 2,000 9,462E-04 9,137E-03 ! negative regulation of cell activation GO:0050866 69 37 2,000 9,462E-04 9,101E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 9,47E-04 9,072E-03 ! neutral lipid catabolic process GO:0046461 14 9 1,000 9,47E-04 9,037E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 9,47E-04 9,002E-03 ! T cell selection GO:0045058 27 9 1,000 9,47E-04 8,967E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 9,47E-04 8,932E-03 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 9,47E-04 8,898E-03 ! renal water homeostasis GO:0003091 15 9 1,000 9,47E-04 8,864E-03 ! purine base metabolic process GO:0006144 25 9 1,000 9,47E-04 8,83E-03 ! regulation of muscle adaptation GO:0043502 14 9 1,000 9,47E-04 8,796E-03 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 1,000 9,47E-04 8,763E-03 ! response to nutrient GO:0007584 135 84 3,000 9,908E-04 9,134E-03 ! embryonic skeletal system morphogenesis GO:0048704 68 38 2,000 1,023E-03 9,399E-03 ! regulation of protein stability GO:0031647 77 38 2,000 1,023E-03 9,364E-03 ! pigment metabolic process GO:0042440 87 38 2,000 1,023E-03 9,329E-03 ! hemostasis GO:0007599 165 85 3,000 1,036E-03 9,404E-03 ! mitochondrion organization GO:0007005 159 87 3,000 1,129E-03 0,01021734 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 1,000 1,18E-03 0,01063424 ! regulation of developmental growth GO:0048638 16 10 1,000 1,18E-03 0,01059515 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,18E-03 0,01055634 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 1,000 1,18E-03 0,01051781 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 1,18E-03 0,01047956 ! positive regulation of heart contraction GO:0045823 17 10 1,000 1,18E-03 0,01044159 ! lung alveolus development GO:0048286 26 10 1,000 1,18E-03 0,0104039 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,18E-03 0,01036647 GO:0006600|creatine metabolic process, ! B cell proliferation GO:0042100 19 10 1,000 1,18E-03 0,01032932 ! nucleobase biosynthetic process GO:0046112 26 10 1,000 1,18E-03 0,01029243 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,18E-03 0,0102558 ! motor axon guidance GO:0008045 22 10 1,000 1,18E-03 0,01021943 ! regulation of bone resorption GO:0045124 25 10 1,000 1,18E-03 0,01018332 ! protein heterooligomerization GO:0051291 17 10 1,000 1,18E-03 0,01014746 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,18E-03 0,01011186 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 1,18E-03 0,0100765 ! multicellular organismal water homeostasis GO:0050891 16 10 1,000 1,18E-03 0,01004139 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,18E-03 0,01000653 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 1,18E-03 9,972E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 1,18E-03 9,938E-03 ! mammary gland development GO:0030879 93 40 2,000 1,19E-03 9,986E-03 ! regulation of action potential in neuron GO:0019228 80 40 2,000 1,19E-03 9,952E-03 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 2,000 1,279E-03 0,01066022 ! mesenchymal cell development GO:0014031 94 41 2,000 1,279E-03 0,01062396 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of protein modification process GO:0031401 156 90 3,000 1,281E-03 0,01060591 ! gland development GO:0048732 220 91 3,000 1,334E-03 0,01101162 ! ear morphogenesis GO:0042471 64 42 2,000 1,372E-03 0,01128252 ! regulation of T cell differentiation GO:0045580 78 42 2,000 1,372E-03 0,01124466 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 1,372E-03 0,01120705 ! regulation of cell adhesion GO:0030155 241 92 3,000 1,389E-03 0,01131299 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,437E-03 0,01166195 ! blood vessel remodeling GO:0001974 30 11 1,000 1,437E-03 0,01162333 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,437E-03 0,01158497 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,437E-03 0,01154686 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,437E-03 0,01150901 ! behavioral fear response GO:0001662 27 11 1,000 1,437E-03 0,0114714 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 1,000 1,437E-03 0,01143403 ! negative regulation of ossification GO:0030279 27 11 1,000 1,437E-03 0,01139691 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,437E-03 0,01136002 ! vasoconstriction GO:0042310 20 11 1,000 1,437E-03 0,01132338 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,437E-03 0,01128697 ! thymus development GO:0048538 29 11 1,000 1,437E-03 0,01125079 ! oocyte development GO:0048599 20 11 1,000 1,437E-03 0,01121485 ! regulation of embryonic development GO:0045995 35 11 1,000 1,437E-03 0,01117913 ! glucose transport GO:0015758 66 43 2,000 1,469E-03 0,01139213 ! regulation of T cell proliferation GO:0042129 80 43 2,000 1,469E-03 0,01135608 ! response to reactive oxygen species GO:0000302 75 44 2,000 1,57E-03 0,01210236 ! hexose transport GO:0008645 68 44 2,000 1,57E-03 0,0120643 GO:0015749|monosaccharide transport, ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 1,676E-03 0,01283651 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,718E-03 0,01311841 ! virus-host interaction GO:0019048 30 12 1,000 1,718E-03 0,01307754 ! cranial nerve development GO:0021545 23 12 1,000 1,718E-03 0,01303693 ! histone acetylation GO:0016573 27 12 1,000 1,718E-03 0,01299657 ! autonomic nervous system development GO:0048483 24 12 1,000 1,718E-03 0,01295645 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,718E-03 0,01291659 ! T cell homeostasis GO:0043029 28 12 1,000 1,718E-03 0,01287697 ! regulation of leukocyte migration GO:0002685 29 12 1,000 1,718E-03 0,01283759 ! oocyte differentiation GO:0009994 21 12 1,000 1,718E-03 0,01279845 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 1,718E-03 0,01275955 ! localization within membrane GO:0051668 26 12 1,000 1,718E-03 0,01272088 ! regulation of JNK cascade GO:0046328 104 47 2,000 1,901E-03 0,0140293 ! positive regulation of defense response GO:0031349 88 48 2,000 2,02E-03 0,01486282 ! mitochondrial transport GO:0006839 94 48 2,000 2,02E-03 0,01481818 ! cellular component disassembly GO:0022411 89 48 2,000 2,02E-03 0,01477382 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 2,000 2,02E-03 0,01472972 ! vascular process in circulatory system GO:0003018 85 48 2,000 2,02E-03 0,01468588 ! regulation of inflammatory response GO:0050727 84 48 2,000 2,02E-03 0,0146423 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,024E-03 0,01462776 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 1,000 2,024E-03 0,01458461 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,024E-03 0,01454172 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,024E-03 0,01449907 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,024E-03 0,01445668 ! histone methylation GO:0016571 29 13 1,000 2,024E-03 0,01441453 ! gland morphogenesis GO:0022612 31 13 1,000 2,024E-03 0,01437263 ! spleen development GO:0048536 24 13 1,000 2,024E-03 0,01433097 ! regulation of mRNA stability GO:0043488 32 13 1,000 2,024E-03 0,01428955 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,024E-03 0,01424837 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 2,143E-03 0,01504683 ! regulation of action potential GO:0001508 102 50 2,000 2,272E-03 0,01590078 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 2,272E-03 0,01585535 ! hair follicle morphogenesis GO:0031069 27 14 1,000 2,353E-03 0,01637751 ! cell-cell junction assembly GO:0007043 32 14 1,000 2,353E-03 0,01633098 ! regulation of heart rate GO:0002027 25 14 1,000 2,353E-03 0,01628472 ! fear response GO:0042596 34 14 1,000 2,353E-03 0,01623871 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 2,353E-03 0,01619297 ! cell wall macromolecule catabolic process GO:0016998 16 14 1,000 2,353E-03 0,01614749 ! response to gamma radiation GO:0010332 30 14 1,000 2,353E-03 0,01610225 ! regulation of RNA stability GO:0043487 33 14 1,000 2,353E-03 0,01605728 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 2,353E-03 0,01601255 ! negative regulation of immune system process GO:0002683 101 51 2,000 2,404E-03 0,01631616 ! histone modification GO:0016570 104 52 2,000 2,542E-03 0,0172016 ! chromatin remodeling GO:0006338 122 53 2,000 2,684E-03 0,01811431 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,706E-03 0,01821001 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,706E-03 0,01815999 ! G1/S transition checkpoint GO:0031575 37 15 1,000 2,706E-03 0,01811023 ! water homeostasis GO:0030104 28 15 1,000 2,706E-03 0,01806075 ! cAMP biosynthetic process GO:0006171 25 15 1,000 2,706E-03 0,01801154 ! lymphocyte homeostasis GO:0002260 33 15 1,000 2,706E-03 0,01796259 ! cell wall macromolecule metabolic process GO:0044036 17 15 1,000 2,706E-03 0,01791392 ! embryonic skeletal system development GO:0048706 101 54 2,000 2,831E-03 0,01869395 ! membrane fusion GO:0006944 122 54 2,000 2,831E-03 0,01864357 ! covalent chromatin modification GO:0016569 115 54 2,000 2,831E-03 0,01859345 ! regulation of cell shape GO:0008360 142 54 2,000 2,831E-03 0,0185436 ! epithelial tube morphogenesis GO:0060562 114 54 2,000 2,831E-03 0,01849402 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 2,000 2,983E-03 0,01943481 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,082E-03 0,0200233 ! positive regulation of cell size GO:0045793 29 16 1,000 3,082E-03 0,01997019 ! heterophilic cell adhesion GO:0007157 43 16 1,000 3,082E-03 0,01991736 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 1,000 3,082E-03 0,01986481 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! DNA replication initiation GO:0006270 28 16 1,000 3,082E-03 0,01981253 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 1,000 3,082E-03 0,01976053 ! regulation of DNA replication GO:0006275 105 56 2,000 3,14E-03 0,02008215 ! regulation of bone remodeling GO:0046850 143 57 2,000 3,302E-03 0,02106232 ! aging GO:0007568 112 58 2,000 3,469E-03 0,02206935 ! regulation of tissue remodeling GO:0034103 146 58 2,000 3,469E-03 0,02201203 ! metencephalon development GO:0022037 32 17 1,000 3,481E-03 0,02202973 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 3,481E-03 0,02197281 ! signal complex assembly GO:0007172 47 17 1,000 3,481E-03 0,02191618 ! regulation of muscle cell differentiation GO:0051147 36 17 1,000 3,481E-03 0,02185984 ! activation of MAPKK activity GO:0000186 43 17 1,000 3,481E-03 0,02180379 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 3,481E-03 0,02174802 ! regulation of survival gene product expression GO:0045884 38 17 1,000 3,481E-03 0,02169254 ! regulation of protein binding GO:0043393 33 17 1,000 3,481E-03 0,02163734 ! nucleobase metabolic process GO:0009112 43 17 1,000 3,481E-03 0,02158243 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 3,481E-03 0,02152779 ! DNA catabolic process GO:0006308 94 60 2,000 3,818E-03 0,02355421 ! kidney development GO:0001822 133 60 2,000 3,818E-03 0,02349488 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 3,902E-03 0,02395421 GO:0050886|endocrine process, ! patterning of blood vessels GO:0001569 43 18 1,000 3,902E-03 0,02389418 ! regulation of viral genome replication GO:0045069 30 18 1,000 3,902E-03 0,02383444 ! epidermis morphogenesis GO:0048730 43 18 1,000 3,902E-03 0,023775 ! glutamine metabolic process GO:0006541 29 18 1,000 3,902E-03 0,02371586 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 3,902E-03 0,02365701 ! nerve development GO:0021675 34 18 1,000 3,902E-03 0,02359846 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 4E-03 0,02413028 ! regulation of homeostatic process GO:0032844 148 62 2,000 4,188E-03 0,025199 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 1,000 4,347E-03 0,02609106 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 4,347E-03 0,02602712 ! memory GO:0007613 34 19 1,000 4,347E-03 0,02596348 ! mitotic chromosome condensation GO:0007076 37 19 1,000 4,347E-03 0,02590015 ! neuromuscular junction development GO:0007528 43 19 1,000 4,347E-03 0,02583714 ! peptide cross-linking GO:0018149 39 19 1,000 4,347E-03 0,02577442 ! cellular pigmentation GO:0033059 37 19 1,000 4,347E-03 0,02571202 ! peptide hormone secretion GO:0030072 32 19 1,000 4,347E-03 0,02564991 ! mesoderm development GO:0007498 128 63 2,000 4,381E-03 0,02578715 ! skeletal system morphogenesis GO:0048705 118 63 2,000 4,381E-03 0,02572516 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 2,000 4,782E-03 0,0280152 ! nucleoside monophosphate metabolic process GO:0009123 117 65 2,000 4,782E-03 0,02794818 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 4,813E-03 0,02806382 ! protein amino acid acetylation GO:0006473 41 20 1,000 4,813E-03 0,027997 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 4,813E-03 0,0279305 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 1,000 4,813E-03 0,02786432 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 4,813E-03 0,02779844 ! actin filament bundle formation GO:0051017 47 20 1,000 4,813E-03 0,02773288 ! body fluid secretion GO:0007589 33 20 1,000 4,813E-03 0,02766763 ! peptide secretion GO:0002790 38 20 1,000 4,813E-03 0,02760268 ! cell-cell junction organization GO:0045216 43 20 1,000 4,813E-03 0,02753804 ! negative regulation of translation GO:0017148 32 20 1,000 4,813E-03 0,0274737 ! chromosome segregation GO:0007059 127 67 2,000 5,205E-03 0,02964006 ! secondary metabolic process GO:0019748 125 67 2,000 5,205E-03 0,02957113 ! hormone secretion GO:0046879 39 21 1,000 5,302E-03 0,03005156 ! lipid phosphorylation GO:0046834 43 21 1,000 5,302E-03 0,029982 ! cAMP metabolic process GO:0046058 41 21 1,000 5,302E-03 0,02991276 ! C21-steroid hormone metabolic process GO:0008207 38 21 1,000 5,302E-03 0,02984383 ! ovarian follicle development GO:0001541 39 21 1,000 5,302E-03 0,02977523 ! smooth muscle contraction GO:0006939 48 21 1,000 5,302E-03 0,02970694 ! regulation of cellular response to stress GO:0080135 142 68 2,000 5,425E-03 0,03032531 ! lung development GO:0030324 165 69 2,000 5,65E-03 0,03151178 ! urogenital system development GO:0001655 149 69 2,000 5,65E-03 0,03144 ! glutamate signaling pathway GO:0007215 48 22 1,000 5,812E-03 0,03227028 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 5,812E-03 0,03219711 ! cell aging GO:0007569 48 22 1,000 5,812E-03 0,03212426 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 5,812E-03 0,03205175 ! peptidyl-serine modification GO:0018209 50 22 1,000 5,812E-03 0,03197956 ! positive regulation of B cell activation GO:0050871 42 22 1,000 5,812E-03 0,0319077 ! gut development GO:0048565 44 22 1,000 5,812E-03 0,03183615 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 5,812E-03 0,03176493 ! positive regulation of DNA replication GO:0045740 44 23 1,000 6,344E-03 0,03459434 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 6,344E-03 0,03451729 ! regeneration GO:0031099 42 23 1,000 6,344E-03 0,03444059 ! response to ethanol GO:0045471 47 23 1,000 6,344E-03 0,03436422 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 6,344E-03 0,03428819 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 6,344E-03 0,0342125 ! hormone transport GO:0009914 41 23 1,000 6,344E-03 0,03413714 ! carbohydrate transport GO:0008643 114 72 2,000 6,358E-03 0,03413972 ! respiratory tube development GO:0030323 171 72 2,000 6,358E-03 0,03406485 ! actin filament organization GO:0007015 167 72 2,000 6,358E-03 0,03399031 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 6,358E-03 0,0339161 ! respiratory system development GO:0060541 175 74 2,000 6,859E-03 0,03650657 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 6,897E-03 0,03662971 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 6,897E-03 0,03655025 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 6,897E-03 0,03647114 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 6,897E-03 0,03639236 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 6,897E-03 0,03631393 ! sex determination GO:0007530 48 24 1,000 6,897E-03 0,03623584 ! regulation of viral reproduction GO:0050792 41 24 1,000 6,897E-03 0,03615808 ! membrane depolarization GO:0051899 45 24 1,000 6,897E-03 0,03608065 ! oogenesis GO:0048477 44 24 1,000 6,897E-03 0,03600356 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 6,897E-03 0,03592679 ! platelet activation GO:0030168 41 24 1,000 6,897E-03 0,03585035 ! regulation of transcription factor activity GO:0051090 137 75 2,000 7,118E-03 0,03691895 GO:0090046|regulation of transcription regulator activity, ! learning or memory GO:0007611 161 76 2,000 7,382E-03 0,03821001 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 7,471E-03 0,03858892 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 7,471E-03 0,0385075 ! leukocyte adhesion GO:0007159 55 25 1,000 7,471E-03 0,03842644 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 7,471E-03 0,03834571 ! vasculogenesis GO:0001570 49 25 1,000 7,471E-03 0,03826532 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 7,471E-03 0,03818527 ! negative regulation of DNA replication GO:0008156 45 25 1,000 7,471E-03 0,03810555 ! chromosome condensation GO:0030261 48 25 1,000 7,471E-03 0,03802616 ! interaction with host GO:0051701 66 25 1,000 7,471E-03 0,0379471 ! lymphocyte proliferation GO:0046651 55 25 1,000 7,471E-03 0,03786838 ! leukocyte homeostasis GO:0001776 50 25 1,000 7,471E-03 0,03778997 ! protein tetramerization GO:0051262 57 25 1,000 7,471E-03 0,0377119 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 8,066E-03 0,0406317 ! molting cycle process GO:0022404 52 26 1,000 8,066E-03 0,0405481 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein amino acid alkylation GO:0008213 59 26 1,000 8,066E-03 0,04046484 GO:0006479|protein amino acid methylation, ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 8,066E-03 0,04038192 ! multicellular organismal response to stress GO:0033555 61 26 1,000 8,066E-03 0,04029933 ! neural crest cell development GO:0014032 59 26 1,000 8,066E-03 0,04021709 GO:0014033|neural crest cell differentiation, ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 1,000 8,066E-03 0,04013518 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 8,066E-03 0,04005361 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 2,000 8,211E-03 0,04068695 ! regulation of synaptic transmission GO:0050804 159 79 2,000 8,211E-03 0,04060459 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 8,682E-03 0,04284961 ! cellular response to oxidative stress GO:0034599 43 27 1,000 8,682E-03 0,04276322 ! regulation of chromosome organization GO:0033044 49 27 1,000 8,682E-03 0,04267717 ! leukocyte proliferation GO:0070661 59 27 1,000 8,682E-03 0,04259148 GO:0032943|mononuclear cell proliferation, ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 9,318E-03 0,04562032 ! spliceosomal snRNP biogenesis GO:0000387 40 28 1,000 9,318E-03 0,04552908 ! protein amino acid acylation GO:0043543 59 28 1,000 9,318E-03 0,0454382 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 1,000 9,318E-03 0,04534769 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 9,318E-03 0,04525753 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 9,318E-03 0,04516774 ! T cell activation GO:0042110 189 84 2,000 9,708E-03 0,04696486 ! regulation of ligase activity GO:0051340 147 84 2,000 9,708E-03 0,04687204 ! respiratory gaseous exchange GO:0007585 61 29 1,000 9,975E-03 0,04806267 ! response to organic cyclic substance GO:0014070 58 29 1,000 9,975E-03 0,04796806 ! somitogenesis GO:0001756 52 29 1,000 9,975E-03 0,04787382 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 9,975E-03 0,04777995 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,01002554 0,04793034 ! regulation of transmission of nerve impulse GO:0051969 167 85 2,000 0,01002554 0,04783673 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 1,000 0,01065072 0,05072069 ! acute-phase response GO:0006953 50 30 1,000 0,01065072 0,05062201 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,01065072 0,05052372 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 0,01065072 0,0504258 GO:0048871|multicellular organismal homeostasis, ! ovulation cycle process GO:0022602 55 31 1,000 0,01134663 0,05361665 ! peptide transport GO:0015833 60 31 1,000 0,01134663 0,05351315 ! male gonad development GO:0008584 56 31 1,000 0,01134663 0,05341004 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,01134663 0,05330733 ! response to heat GO:0009408 54 31 1,000 0,01134663 0,05320501 ! regulation of neurological system process GO:0031644 175 89 2,000 0,0113547 0,05314088 ! regulation of DNA binding GO:0051101 167 89 2,000 0,0113547 0,05303927 ! ossification GO:0001503 205 91 2,000 0,01205553 0,05620547 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,01206202 0,05612862 ! spindle organization GO:0007051 50 32 1,000 0,01206202 0,05602191 ! mesoderm formation GO:0001707 73 32 1,000 0,01206202 0,0559156 ! ovulation cycle GO:0042698 57 32 1,000 0,01206202 0,0558097 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01206202 0,0557042 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01206202 0,0555991 ! bone development GO:0060348 206 92 2,000 0,01241507 0,05711868 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 0,01278071 0,05869038 ! regulation of pH GO:0006885 56 33 1,000 0,01279669 0,0586535 ! pigment biosynthetic process GO:0046148 73 33 1,000 0,01279669 0,05854366 ! female pregnancy GO:0007565 166 94 2,000 0,01315247 0,06005886 ! regulation of defense response GO:0031347 171 95 2,000 0,01353036 0,06166917 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01355041 0,06164555 ! post-embryonic development GO:0009791 76 34 1,000 0,01355041 0,06153097 ! inner ear morphogenesis GO:0042472 51 34 1,000 0,01355041 0,06141681 ! formation of primary germ layer GO:0001704 76 34 1,000 0,01355041 0,06130307 ! cell fate specification GO:0001708 56 34 1,000 0,01355041 0,06118976 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01355041 0,06107686 ! regulation of T cell activation GO:0050863 175 96 2,000 0,0139144 0,06260198 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 0,01430459 0,06423918 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01432297 0,06420372 ! regulation of synaptic plasticity GO:0048167 78 35 1,000 0,01432297 0,06408613 ! mesoderm morphogenesis GO:0048332 80 35 1,000 0,01432297 0,06396897 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,01511416 0,06737936 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,01511416 0,06725663 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01511416 0,06713434 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01551222 0,06877743 GO:0060538|skeletal muscle organ development, ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01592375 0,07047415 ! tissue remodeling GO:0048771 78 37 1,000 0,01592375 0,07034671 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,01592375 0,07021973 ! female gonad development GO:0008585 71 37 1,000 0,01592375 0,0700932 ! hormone biosynthetic process GO:0042446 62 37 1,000 0,01592375 0,06996714 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,01675155 0,07347223 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 0,01675155 0,07334056 ! meiosis I GO:0007127 74 38 1,000 0,01675155 0,07320936 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,01675155 0,07307863 ! cyclic nucleotide metabolic process GO:0009187 69 38 1,000 0,01675155 0,07294837 ! negative regulation of binding GO:0051100 71 39 1,000 0,01759733 0,07649518 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,01759733 0,07635931 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01759733 0,07622392 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! learning GO:0007612 82 40 1,000 0,0184609 0,07982299 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,0184609 0,07968196 GO:0046660|female sex differentiation, ! cellular amide metabolic process GO:0043603 73 41 1,000 0,01934205 0,08333798 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01934205 0,08319126 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,01934205 0,08304505 ! maintenance of protein location GO:0045185 95 41 1,000 0,01934205 0,08289936 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,02024057 0,08659846 ! T cell differentiation GO:0030217 93 42 1,000 0,02024057 0,08644706 ! regulation of protein secretion GO:0050708 77 42 1,000 0,02024057 0,0862962 ! cytokinesis GO:0000910 84 42 1,000 0,02024057 0,08614585 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02115626 0,08988653 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 76 43 1,000 0,02115626 0,08973048 GO:0050880|regulation of blood vessel size, ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,02115626 0,08957496 ! segmentation GO:0035282 78 43 1,000 0,02115626 0,08941999 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 0,02208893 0,09320077 ! receptor-mediated endocytosis GO:0006898 98 45 1,000 0,02303836 0,09703915 ! biopolymer methylation GO:0043414 91 45 1,000 0,02303836 0,09687213 ! B cell differentiation GO:0030183 124 45 1,000 0,02303836 0,09670568 ! female gamete generation GO:0007292 71 45 1,000 0,02303836 0,0965398 ! developmental growth GO:0048589 88 45 1,000 0,02303836 0,0963745 ! maintenance of location in cell GO:0051651 101 45 1,000 0,02303836 0,09620975 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,02400436 0,10007279 ! pigmentation GO:0043473 103 46 1,000 0,02400436 0,0999023 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02575602 0,10701014 ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02575602 0,10682846 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02575602 0,10664739 ! neuron fate determination GO:0048664 7 5 0,000 0,02575602 0,10646694 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02575602 0,1062871 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02575602 0,10610786 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02575602 0,10592923 ! polyol transport GO:0015791 12 5 0,000 0,02575602 0,1057512 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02575602 0,10557376 ! response to superoxide GO:0000303 10 5 0,000 0,02575602 0,10539692 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02575602 0,10522067 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02575602 0,10504501 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02575602 0,10486994 ! female meiosis GO:0007143 10 5 0,000 0,02575602 0,10469544 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02575602 0,10452153 ! hypothalamus development GO:0021854 9 5 0,000 0,02575602 0,1043482 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02575602 0,10417543 ! cobalt ion transport GO:0006824 11 5 0,000 0,02575602 0,10400324 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02575602 0,10383162 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02575602 0,10366056 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02575602 0,10349007 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02575602 0,10332014 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02575602 0,10315076 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02575602 0,10298193 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02575602 0,10281366 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02575602 0,10264594 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02575602 0,10247877 ! transposition GO:0032196 9 5 0,000 0,02575602 0,10231213 ! negative chemotaxis GO:0050919 16 5 0,000 0,02575602 0,10214604 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02575602 0,10198049 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02575602 0,10181547 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02575602 0,10165099 ! behavioral response to pain GO:0048266 10 5 0,000 0,02575602 0,10148704 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02575602 0,10132361 ! Notch receptor processing GO:0007220 11 5 0,000 0,02575602 0,10116071 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02575602 0,10099833 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! micturition GO:0060073 9 5 0,000 0,02575602 0,10083648 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02575602 0,10067514 ! copulation GO:0007620 9 5 0,000 0,02575602 0,10051432 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02575602 0,10035401 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02575602 0,10019421 ! bioluminescence GO:0008218 9 5 0,000 0,02575602 0,10003492 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02575602 0,09987613 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02575602 0,09971785 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02575602 0,09956007 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02575602 0,09940278 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02575602 0,099246 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02575602 0,0990897 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02575602 0,0989339 ! grooming behavior GO:0007625 6 5 0,000 0,02575602 0,09877859 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02575602 0,09862377 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02575602 0,09846942 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02575602 0,09831557 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02575602 0,09816219 ! response to protozoan GO:0001562 13 5 0,000 0,02575602 0,09800929 ! lymph vessel development GO:0001945 10 5 0,000 0,02575602 0,09785686 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02575602 0,09770491 ! endochondral ossification GO:0001958 17 5 0,000 0,02575602 0,09755343 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02575602 0,09740242 ! single strand break repair GO:0000012 8 5 0,000 0,02575602 0,09725187 ! parathyroid gland development GO:0060017 14 5 0,000 0,02575602 0,09710179 ! anagen GO:0042640 7 5 0,000 0,02575602 0,09695218 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02575602 0,09680302 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02575602 0,09665432 ! cytokine secretion GO:0050663 15 5 0,000 0,02575602 0,09650608 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02575602 0,09635829 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02575602 0,09621095 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02575602 0,09606406 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02575602 0,09591763 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02575602 0,09577163 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02575602 0,09562608 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02575602 0,09548097 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02575602 0,09533631 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02575602 0,09519208 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02575602 0,09504828 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02575602 0,09490492 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02575602 0,09476199 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02575602 0,09461949 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02575602 0,09447742 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02575602 0,09433578 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02575602 0,09419455 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02575602 0,09405376 ! polyol catabolic process GO:0046174 9 5 0,000 0,02575602 0,09391338 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02575602 0,09377342 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02575602 0,09363387 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02575602 0,09349474 ! mitochondrial fission GO:0000266 8 5 0,000 0,02575602 0,09335603 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02575602 0,09321772 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02575602 0,09307983 ! mRNA transcription GO:0009299 10 5 0,000 0,02575602 0,09294234 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02575602 0,09280525 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02575602 0,09266857 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02575602 0,0925323 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02575602 0,09239642 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02575602 0,09226094 ! monocyte activation GO:0042117 10 5 0,000 0,02575602 0,09212586 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02575602 0,09199117 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02575602 0,09185688 ! response to food GO:0032094 6 5 0,000 0,02575602 0,09172298 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02575602 0,09158946 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02575602 0,09145634 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02575602 0,0913236 ! forebrain neuron development GO:0021884 13 5 0,000 0,02575602 0,09119125 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02575602 0,09105928 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02575602 0,09092769 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02575602 0,09079648 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02575602 0,09066565 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02575602 0,0905352 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02575602 0,09040512 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02575602 0,09027541 ! lipid glycosylation GO:0030259 7 5 0,000 0,02575602 0,09014608 ! nucleobase transport GO:0015851 6 5 0,000 0,02575602 0,09001711 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02575602 0,08988852 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02575602 0,08976029 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02575602 0,08963242 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02575602 0,08950492 ! basic amino acid transport GO:0015802 12 5 0,000 0,02575602 0,08937779 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02575602 0,08925101 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02575602 0,08912459 ! actin nucleation GO:0045010 11 5 0,000 0,02575602 0,08899853 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02575602 0,08887283 ! depurination GO:0045007 5 5 0,000 0,02575602 0,08874748 ! depyrimidination GO:0045008 10 5 0,000 0,02575602 0,08862248 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02575602 0,08849784 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02575602 0,08837354 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02575602 0,0882496 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02575602 0,088126 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02575602 0,08800274 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02575602 0,08787984 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02575602 0,08775727 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02575602 0,08763504 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02575602 0,08751316 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02575602 0,08739161 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02575602 0,08727041 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02575602 0,08714953 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02575602 0,08702899 ! response to arsenic GO:0046685 11 5 0,000 0,02575602 0,08690879 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02575602 0,08678891 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02575602 0,08666937 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02575602 0,08655015 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02575602 0,08643127 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02575602 0,08631271 ! response to mercury ion GO:0046689 8 5 0,000 0,02575602 0,08619447 ! response to cadmium ion GO:0046686 7 5 0,000 0,02575602 0,08607656 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02575602 0,08595896 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02575602 0,08584169 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02575602 0,08572474 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02575602 0,08560811 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02575602 0,0854918 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02575602 0,0853758 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02575602 0,08526011 ! decidualization GO:0046697 11 5 0,000 0,02575602 0,08514474 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02575602 0,08502968 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02575602 0,08491493 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02575602 0,08480049 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02575602 0,08468636 ! embryonic cleavage GO:0040016 6 5 0,000 0,02575602 0,08457253 ! peroxisome fission GO:0016559 5 5 0,000 0,02575602 0,08445901 ! histone demethylation GO:0016577 13 5 0,000 0,02575602 0,08434579 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02575602 0,08423288 ! mitotic recombination GO:0006312 9 5 0,000 0,02575602 0,08412027 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02575602 0,08400796 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02575602 0,08389595 ! metaphase plate congression GO:0051310 7 5 0,000 0,02575602 0,08378424 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02575602 0,08367282 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02575602 0,0835617 ! enteric nervous system development GO:0048484 8 5 0,000 0,02575602 0,08345088 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02575602 0,08334035 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02575602 0,08323011 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02575602 0,08312016 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02575602 0,0830105 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02575602 0,08290114 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02575602 0,08279206 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02575602 0,08268326 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02575602 0,08257475 ! metaphase GO:0051323 11 5 0,000 0,02575602 0,08246653 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02575602 0,08235859 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02575602 0,08225093 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02575602 0,08214355 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02575602 0,08203646 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02575602 0,08192964 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02575602 0,0818231 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02575602 0,08171683 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02575602 0,08161085 ! response to redox state GO:0051775 6 5 0,000 0,02575602 0,08150513 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02575602 0,08139969 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02575602 0,08129452 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02575602 0,08118963 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02575602 0,081085 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02575602 0,08098065 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02575602 0,08087656 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02575602 0,08077274 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02575602 0,08066918 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02575602 0,08056589 ! striatum development GO:0021756 14 5 0,000 0,02575602 0,08046287 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02575602 0,08036011 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02575602 0,0802576 ! glial cell migration GO:0008347 10 5 0,000 0,02575602 0,08015537 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02575602 0,08005339 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02575602 0,07995167 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02575602 0,07985021 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02575602 0,079749 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02575602 0,07964805 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02575602 0,07954736 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02575602 0,07944692 ! neuroprotection GO:0043526 8 5 0,000 0,02575602 0,07934674 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02575602 0,0792468 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02575602 0,07914712 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02575602 0,07904769 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02575602 0,07894851 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02575602 0,07884958 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02575602 0,07875089 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02575602 0,07865245 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02575602 0,07855426 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02575602 0,07845631 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02575602 0,07835861 ! spindle assembly GO:0051225 6 5 0,000 0,02575602 0,07826115 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02575602 0,07816393 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02575602 0,07806695 ! protein palmitoylation GO:0018345 12 5 0,000 0,02575602 0,07797021 ! drug metabolic process GO:0017144 7 5 0,000 0,02575602 0,07787372 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02575602 0,07777746 ! organ regeneration GO:0031100 7 5 0,000 0,02575602 0,07768143 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02575602 0,07758565 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02575602 0,0774901 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,0259853 0,07808375 ! endosome transport GO:0016197 127 48 1,000 0,0259853 0,07798783 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,0259853 0,07789214 ! male sex differentiation GO:0046661 93 48 1,000 0,0259853 0,07779668 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,0259853 0,07770146 ! methylation GO:0032259 97 48 1,000 0,0259853 0,07760647 ! JNK cascade GO:0007254 106 49 1,000 0,02699985 0,08053802 ! activation of caspase activity GO:0006919 95 50 1,000 0,0280302 0,08350948 ! regulation of ossification GO:0030278 123 50 1,000 0,0280302 0,08340776 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,02907615 0,08641488 ! peptide metabolic process GO:0006518 80 51 1,000 0,02907615 0,08630988 ! response to temperature stimulus GO:0009266 84 51 1,000 0,02907615 0,08620514 ! positive regulation of binding GO:0051099 88 52 1,000 0,03013752 0,08924359 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,03013752 0,08913555 ! excretion GO:0007588 87 52 1,000 0,03013752 0,08902777 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,03013752 0,08892025 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,0308275 0,09084629 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,0308275 0,09073684 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,0308275 0,09062765 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,0308275 0,09051872 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,0308275 0,09041005 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,0308275 0,09030165 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,0308275 0,0901935 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,0308275 0,09008562 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,0308275 0,08997799 ! response to oxygen radical GO:0000305 11 6 0,000 0,0308275 0,08987061 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,0308275 0,0897635 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,0308275 0,08965664 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,0308275 0,08955003 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,0308275 0,08944368 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,0308275 0,08933757 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,0308275 0,08923172 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,0308275 0,08912612 ! forebrain regionalization GO:0021871 9 6 0,000 0,0308275 0,08902077 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,0308275 0,08891567 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,0308275 0,08881082 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,0308275 0,08870621 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,0308275 0,08860185 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,0308275 0,08849774 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,0308275 0,08839387 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,0308275 0,08829024 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,0308275 0,08818686 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,0308275 0,08808371 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,0308275 0,08798081 ! malate metabolic process GO:0006108 13 6 0,000 0,0308275 0,08787815 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,0308275 0,08777573 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,0308275 0,08767354 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,0308275 0,0875716 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,0308275 0,08746989 ! protein refolding GO:0042026 15 6 0,000 0,0308275 0,08736842 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,0308275 0,08726718 ! opsonization GO:0008228 8 6 0,000 0,0308275 0,08716617 ! mating behavior GO:0007617 7 6 0,000 0,0308275 0,0870654 ! erythrocyte maturation GO:0043249 8 6 0,000 0,0308275 0,08696487 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,0308275 0,08686456 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,0308275 0,08676449 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,0308275 0,08666464 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,0308275 0,08656503 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,0308275 0,08646564 ! response to interferon-gamma GO:0034341 16 6 0,000 0,0308275 0,08636648 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,0308275 0,08626755 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,0308275 0,08616885 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,0308275 0,08607037 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,0308275 0,08597212 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,0308275 0,08587409 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,0308275 0,08577628 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,0308275 0,0856787 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,0308275 0,08558133 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,0308275 0,08548419 ! thymic T cell selection GO:0045061 16 6 0,000 0,0308275 0,08538727 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,0308275 0,08529057 ! protein lipoylation GO:0009249 10 6 0,000 0,0308275 0,08519409 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,0308275 0,08509782 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,0308275 0,08500178 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,0308275 0,08490595 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,0308275 0,08481033 ! glutamate catabolic process GO:0006538 12 6 0,000 0,0308275 0,08471493 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,0308275 0,08461975 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,0308275 0,08452478 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,0308275 0,08443002 ! hyperosmotic response GO:0006972 10 6 0,000 0,0308275 0,08433547 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,0308275 0,08424113 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,0308275 0,08414701 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,0308275 0,0840531 ! urea metabolic process GO:0019627 7 6 0,000 0,0308275 0,08395939 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,0308275 0,0838659 ! neutrophil activation GO:0042119 7 6 0,000 0,0308275 0,08377261 ! regulation of appetite GO:0032098 10 6 0,000 0,0308275 0,08367953 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,0308275 0,08358665 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,0308275 0,08349399 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,0308275 0,08340152 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,0308275 0,08330926 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,0308275 0,08321721 ! T cell mediated immunity GO:0002456 17 6 0,000 0,0308275 0,08312536 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,0308275 0,08303371 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,0308275 0,08294226 ! carnitine transport GO:0015879 10 6 0,000 0,0308275 0,08285102 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0308275 0,08275997 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,0308275 0,08266913 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,0308275 0,08257848 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,0308275 0,08248803 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,0308275 0,08239778 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,0308275 0,08230773 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,0308275 0,08221788 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,0308275 0,08212822 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,0308275 0,08203875 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,0308275 0,08194948 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,0308275 0,08186041 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,0308275 0,08177153 ! astrocyte development GO:0014002 16 6 0,000 0,0308275 0,08168284 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,0308275 0,08159434 ! interaction with symbiont GO:0051702 14 6 0,000 0,0308275 0,08150603 ! regulation of dendrite development GO:0050773 16 6 0,000 0,0308275 0,08141792 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,0308275 0,08132999 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,0308275 0,08124226 ! response to copper ion GO:0046688 10 6 0,000 0,0308275 0,08115471 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,0308275 0,08106736 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,0308275 0,08098019 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0308275 0,08089321 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,0308275 0,08080641 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,0308275 0,0807198 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,0308275 0,08063338 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,0308275 0,08054714 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,0308275 0,08046108 ! hair follicle maturation GO:0048820 8 6 0,000 0,0308275 0,08037521 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,0308275 0,08028953 ! Schwann cell development GO:0014044 15 6 0,000 0,0308275 0,08020402 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,0308275 0,0801187 ! response to pheromone GO:0019236 6 6 0,000 0,0308275 0,08003355 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,0308275 0,07994859 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,0308275 0,07986381 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,0308275 0,07977921 ! subpallium development GO:0021544 15 6 0,000 0,0308275 0,07969479 ! neural tube patterning GO:0021532 8 6 0,000 0,0308275 0,07961054 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,0308275 0,07952648 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,0308275 0,07944259 ! maintenance of organ identity GO:0048496 9 6 0,000 0,0308275 0,07935888 ! G2 phase GO:0051319 16 6 0,000 0,0308275 0,07927534 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,0308275 0,07919198 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,0308275 0,0791088 ! oxygen homeostasis GO:0032364 10 6 0,000 0,0308275 0,07902579 ! establishment of planar polarity GO:0001736 7 6 0,000 0,0308275 0,07894295 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,0308275 0,07886029 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,0308275 0,0787778 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,0308275 0,07869548 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,0308275 0,07861333 ! receptor internalization GO:0031623 11 6 0,000 0,0308275 0,07853136 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,0308275 0,07844956 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,0308275 0,07836792 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,0308275 0,07828646 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0308275 0,07820517 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,0308275 0,07812404 ! protein deubiquitination GO:0016579 16 6 0,000 0,0308275 0,07804308 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,0308275 0,07796229 ! protein destabilization GO:0031648 9 6 0,000 0,0308275 0,07788167 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,0308275 0,07780121 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,0308275 0,07772092 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,0308275 0,0776408 ! regulation of viral transcription GO:0046782 11 6 0,000 0,0308275 0,07756084 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,0308275 0,07748104 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,0308275 0,07740141 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,0308275 0,07732195 ! determination of adult lifespan GO:0008340 17 6 0,000 0,0308275 0,07724264 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,0308275 0,0771635 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,0308275 0,07708452 ! neural plate development GO:0001840 9 6 0,000 0,0308275 0,0770057 ! catecholamine transport GO:0051937 9 6 0,000 0,0308275 0,07692704 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,0308275 0,07684855 ! sensory cilium assembly GO:0035058 10 6 0,000 0,0308275 0,07677021 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,0308275 0,07669203 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,0308275 0,07661401 ! maternal placenta development GO:0001893 12 6 0,000 0,0308275 0,07653615 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,0308275 0,07645845 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,0308275 0,07638091 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,0308275 0,07630352 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,0308275 0,07622629 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,0308275 0,07614922 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,0308275 0,0760723 GO:0055081|anion homeostasis, ! inner ear development GO:0048839 89 53 1,000 0,03121412 0,07694864 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,03121412 0,07687107 ! vesicle organization GO:0016050 127 53 1,000 0,03121412 0,07679366 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,03121412 0,0767164 ! synapse organization GO:0050808 102 53 1,000 0,03121412 0,0766393 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,03230577 0,07923996 ! glutamine family amino acid metabolic process GO:0009064 85 54 1,000 0,03230577 0,07916048 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,03453347 0,08453434 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,03566916 0,08722699 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,03566916 0,08713976 ! heart morphogenesis GO:0003007 105 57 1,000 0,03566916 0,08705271 ! tRNA transcription GO:0009304 17 7 0,000 0,03587271 0,08746211 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03587271 0,08737491 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03587271 0,08728789 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03587271 0,08720103 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03587271 0,08711435 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03587271 0,08702784 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03587271 0,08694151 ! sleep GO:0030431 16 7 0,000 0,03587271 0,08685534 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03587271 0,08676935 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03587271 0,08668352 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03587271 0,08659786 ! prostate gland development GO:0030850 14 7 0,000 0,03587271 0,08651238 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03587271 0,08642706 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03587271 0,08634191 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03587271 0,08625693 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03587271 0,08617211 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03587271 0,08608746 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03587271 0,08600298 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03587271 0,08591867 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03587271 0,08583451 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03587271 0,08575053 ! glycolipid transport GO:0046836 11 7 0,000 0,03587271 0,08566671 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03587271 0,08558305 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03587271 0,08549955 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03587271 0,08541622 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03587271 0,08533305 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03587271 0,08525004 ! pericardium development GO:0060039 16 7 0,000 0,03587271 0,08516719 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03587271 0,0850845 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03587271 0,08500198 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03587271 0,08491961 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03587271 0,0848374 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03587271 0,08475536 ! lipoprotein transport GO:0042953 14 7 0,000 0,03587271 0,08467347 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03587271 0,08459174 ! rhythmic behavior GO:0007622 17 7 0,000 0,03587271 0,08451016 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03587271 0,08442875 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03587271 0,08434749 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03587271 0,08426638 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03587271 0,08418544 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03587271 0,08410464 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03587271 0,08402401 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03587271 0,08394352 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03587271 0,0838632 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03587271 0,08378302 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03587271 0,083703 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03587271 0,08362313 GO:0045911|positive regulation of DNA recombination, ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03587271 0,08354341 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03587271 0,08346385 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03587271 0,08338443 ! spinal cord patterning GO:0021511 14 7 0,000 0,03587271 0,08330517 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03587271 0,08322606 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03587271 0,0831471 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03587271 0,08306828 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03587271 0,08298962 ! adrenal gland development GO:0030325 17 7 0,000 0,03587271 0,08291111 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03587271 0,08283274 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03587271 0,08275452 ! ovulation GO:0030728 10 7 0,000 0,03587271 0,08267645 ! adenohypophysis development GO:0021984 11 7 0,000 0,03587271 0,08259853 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03587271 0,08252075 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03587271 0,08244312 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03587271 0,08236564 ! microtubule nucleation GO:0007020 21 7 0,000 0,03587271 0,0822883 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03587271 0,08221111 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03587271 0,08213406 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03587271 0,08205715 ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03587271 0,08198039 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03587271 0,08190377 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03587271 0,0818273 ! galactose metabolic process GO:0006012 13 7 0,000 0,03587271 0,08175097 ! vesicle fusion GO:0006906 20 7 0,000 0,03587271 0,08167478 ! response to dietary excess GO:0002021 8 7 0,000 0,03587271 0,08159873 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03587271 0,08152283 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,03587271 0,08144706 ! nucleoside transport GO:0015858 11 7 0,000 0,03587271 0,08137144 ! nucleoside salvage GO:0043174 11 7 0,000 0,03587271 0,08129595 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03587271 0,08122061 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03587271 0,08114541 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03587271 0,08107034 ! parturition GO:0007567 16 7 0,000 0,03587271 0,08099542 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03587271 0,08092063 ! rRNA modification GO:0000154 14 7 0,000 0,03587271 0,08084598 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03587271 0,08077146 ! spindle checkpoint GO:0031577 16 7 0,000 0,03587271 0,08069709 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03587271 0,08062285 ! monocyte differentiation GO:0030224 16 7 0,000 0,03587271 0,08054875 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03587271 0,08047478 ! centrosome duplication GO:0051298 14 7 0,000 0,03587271 0,08040095 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03587271 0,08032726 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03587271 0,0802537 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03587271 0,08018027 ! eating behavior GO:0042755 8 7 0,000 0,03587271 0,08010698 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03587271 0,08003383 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03587271 0,0799608 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03587271 0,07988791 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03587271 0,07981515 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03587271 0,07974253 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03587271 0,07967004 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03587271 0,07959767 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03587271 0,07952544 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03587271 0,07945334 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03587271 0,07938138 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03587271 0,07930954 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03587271 0,07923783 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03587271 0,07916625 ! histone ubiquitination GO:0016574 9 7 0,000 0,03587271 0,0790948 ! regulation of meiosis GO:0040020 12 7 0,000 0,03587271 0,07902348 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03587271 0,07895229 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03587271 0,07888122 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03587271 0,07881029 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03587271 0,07873948 ! transcription termination GO:0006353 14 7 0,000 0,03587271 0,0786688 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03587271 0,07859824 ! anaphase GO:0051322 18 7 0,000 0,03587271 0,07852781 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03587271 0,07845751 ! axonal fasciculation GO:0007413 19 7 0,000 0,03587271 0,07838733 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03587271 0,07831728 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03587271 0,07824736 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03587271 0,07817756 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03587271 0,07810788 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03587271 0,07803833 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03587271 0,0779689 ! antibiotic transport GO:0042891 9 7 0,000 0,03587271 0,07789959 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03587271 0,07783041 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03587271 0,07776135 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03587271 0,07769241 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03587271 0,0776236 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03587271 0,0775549 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03587271 0,07748633 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03587271 0,07741788 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03587271 0,07734955 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03587271 0,07728134 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03587271 0,07721325 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03587271 0,07714528 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03587271 0,07707743 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03587271 0,0770097 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03587271 0,07694209 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03587271 0,0768746 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03587271 0,07680722 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03587271 0,07673996 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03587271 0,07667283 ! muscle adaptation GO:0043500 13 7 0,000 0,03587271 0,0766058 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03587271 0,0765389 ! retina homeostasis GO:0001895 12 7 0,000 0,03587271 0,07647211 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03587271 0,07640544 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03587271 0,07633888 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03587271 0,07627244 ! gastrulation GO:0007369 122 58 1,000 0,03681917 0,07821672 ! maintenance of location GO:0051235 124 58 1,000 0,03681917 0,07814877 ! establishment of organelle localization GO:0051656 122 59 1,000 0,03798332 0,08054969 ! lipid modification GO:0030258 112 60 1,000 0,03916143 0,08297604 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04089181 0,08656732 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04089181 0,08649237 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04089181 0,08641755 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04089181 0,08634286 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04089181 0,0862683 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04089181 0,08619386 ! male meiosis GO:0007140 9 8 0,000 0,04089181 0,08611956 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04089181 0,08604538 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04089181 0,08597133 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04089181 0,08589741 ! meiotic prophase I GO:0007128 14 8 0,000 0,04089181 0,08582361 ! response to zinc ion GO:0010043 12 8 0,000 0,04089181 0,08574995 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04089181 0,0856764 ! oligopeptide transport GO:0006857 16 8 0,000 0,04089181 0,08560299 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04089181 0,0855297 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04089181 0,08545653 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04089181 0,08538349 ! signal peptide processing GO:0006465 12 8 0,000 0,04089181 0,08531058 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04089181 0,08523779 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04089181 0,08516512 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04089181 0,08509258 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04089181 0,08502016 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04089181 0,08494786 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,04089181 0,08487569 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04089181 0,08480364 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04089181 0,08473171 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04089181 0,0846599 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04089181 0,08458822 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04089181 0,08451665 ! reflex GO:0060004 17 8 0,000 0,04089181 0,08444521 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04089181 0,08437389 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04089181 0,08430269 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04089181 0,08423161 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04089181 0,08416065 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04089181 0,0840898 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04089181 0,08401908 ! histidine catabolic process GO:0006548 10 8 0,000 0,04089181 0,08394848 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04089181 0,08387799 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04089181 0,08380762 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04089181 0,08373737 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,04089181 0,08366724 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04089181 0,08359723 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04089181 0,08352733 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04089181 0,08345755 ! macrophage activation GO:0042116 13 8 0,000 0,04089181 0,08338788 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04089181 0,08331834 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04089181 0,08324891 ! purine salvage GO:0043101 12 8 0,000 0,04089181 0,08317959 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04089181 0,08311039 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04089181 0,0830413 ! osteoblast development GO:0002076 17 8 0,000 0,04089181 0,08297233 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04089181 0,08290347 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04089181 0,08283473 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04089181 0,0827661 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04089181 0,08269759 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04089181 0,08262919 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04089181 0,0825609 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04089181 0,08249272 ! intermediate filament organization GO:0045109 12 8 0,000 0,04089181 0,08242466 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04089181 0,08235671 ! cellular extravasation GO:0045123 13 8 0,000 0,04089181 0,08228887 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04089181 0,08222114 ! response to antibiotic GO:0046677 11 8 0,000 0,04089181 0,08215352 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04089181 0,08208602 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04089181 0,08201863 ! DNA topological change GO:0006265 12 8 0,000 0,04089181 0,08195134 ! response to tropane GO:0014073 15 8 0,000 0,04089181 0,08188417 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04089181 0,08181711 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04089181 0,08175015 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04089181 0,08168331 ! mast cell activation GO:0045576 14 8 0,000 0,04089181 0,08161657 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04089181 0,08154995 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04089181 0,08148343 ! gas homeostasis GO:0033483 14 8 0,000 0,04089181 0,08141702 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04089181 0,08135072 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04089181 0,08128453 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04089181 0,08121844 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04089181 0,08115247 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04089181 0,0810866 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04089181 0,08102083 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04089181 0,08095518 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04089181 0,08088962 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04089181 0,08082418 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04089181 0,08075884 ! response to tumor cell GO:0002347 16 8 0,000 0,04089181 0,08069361 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04089181 0,08062848 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04089181 0,08056346 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04089181 0,08049854 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04089181 0,08043372 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04089181 0,08036902 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04089181 0,08030441 ! hormone catabolic process GO:0042447 17 8 0,000 0,04089181 0,08023991 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04089181 0,08017551 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04089181 0,08011122 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04089181 0,08004702 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04089181 0,07998294 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04089181 0,07991895 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04089181 0,07985506 ! adult feeding behavior GO:0008343 10 8 0,000 0,04089181 0,07979128 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04089181 0,0797276 ! ATP catabolic process GO:0006200 11 8 0,000 0,04089181 0,07966402 ! blastocyst growth GO:0001832 19 8 0,000 0,04089181 0,07960055 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04089181 0,07953717 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04089181 0,0794739 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04089181 0,07941072 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04089181 0,07934765 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04089181 0,07928467 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04089181 0,0792218 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04089181 0,07915902 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04089181 0,07909635 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04089181 0,07903377 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04089181 0,07897129 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04089181 0,07890891 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04089181 0,07884663 ! protein prenylation GO:0018342 21 8 0,000 0,04089181 0,07878445 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04089181 0,07872237 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04089181 0,07866038 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04089181 0,07859849 ! viral reproductive process GO:0022415 132 62 1,000 0,04155885 0,07981783 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,04401005 0,08445919 ! axon extension GO:0048675 16 9 0,000 0,04588491 0,0879881 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04588491 0,08791909 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04588491 0,08785019 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04588491 0,0877814 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04588491 0,08771271 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,04588491 0,08764413 ! reproductive behavior GO:0019098 22 9 0,000 0,04588491 0,08757566 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04588491 0,08750729 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04588491 0,08743904 ! UTP metabolic process GO:0046051 10 9 0,000 0,04588491 0,08737088 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04588491 0,08730284 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04588491 0,0872349 ! artery development GO:0060840 25 9 0,000 0,04588491 0,08716706 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04588491 0,08709934 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,04588491 0,08703171 ! equilibrioception GO:0050957 20 9 0,000 0,04588491 0,08696419 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,04588491 0,08689678 ! chemosensory behavior GO:0007635 21 9 0,000 0,04588491 0,08682947 ! microtubule bundle formation GO:0001578 22 9 0,000 0,04588491 0,08676226 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04588491 0,08669516 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04588491 0,08662816 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04588491 0,08656127 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04588491 0,08649448 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04588491 0,08642779 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04588491 0,08636121 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04588491 0,08629472 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04588491 0,08622834 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04588491 0,08616206 ! protein targeting to ER GO:0045047 25 9 0,000 0,04588491 0,08609589 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04588491 0,08602981 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04588491 0,08596384 ! glycine catabolic process GO:0006546 15 9 0,000 0,04588491 0,08589796 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04588491 0,08583219 ! endosome organization GO:0007032 20 9 0,000 0,04588491 0,08576652 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04588491 0,08570095 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04588491 0,08563548 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04588491 0,08557011 ! mannose metabolic process GO:0006013 13 9 0,000 0,04588491 0,08550484 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04588491 0,08543967 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04588491 0,0853746 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04588491 0,08530962 ! receptor clustering GO:0043113 20 9 0,000 0,04588491 0,08524475 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04588491 0,08517997 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04588491 0,0851153 ! retinol metabolic process GO:0042572 20 9 0,000 0,04588491 0,08505072 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04588491 0,08498624 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04588491 0,08492185 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,04588491 0,08485757 ! macrophage differentiation GO:0030225 15 9 0,000 0,04588491 0,08479338 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04588491 0,08472929 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,04588491 0,08466529 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04588491 0,08460139 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04588491 0,08453759 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04588491 0,08447388 ! response to amine stimulus GO:0014075 13 9 0,000 0,04588491 0,08441027 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04588491 0,08434676 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04588491 0,08428334 ! erythrocyte development GO:0048821 17 9 0,000 0,04588491 0,08422002 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04588491 0,08415679 ! postreplication repair GO:0006301 25 9 0,000 0,04588491 0,08409366 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04588491 0,08403062 ! icosanoid secretion GO:0032309 15 9 0,000 0,04588491 0,08396767 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04588491 0,08390482 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04588491 0,08384207 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04588491 0,08377941 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04588491 0,08371684 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04588491 0,08365436 ! sterol catabolic process GO:0016127 14 9 0,000 0,04588491 0,08359198 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04588491 0,08352969 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04588491 0,08346749 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04588491 0,08340539 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,04588491 0,08334338 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,04588491 0,08328146 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04588491 0,08321963 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,04588491 0,0831579 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04588491 0,08309625 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04588491 0,0830347 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04588491 0,08297324 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04588491 0,08291187 ! pigment granule transport GO:0051904 17 9 0,000 0,04588491 0,08285059 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,04588491 0,0827894 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04588491 0,0827283 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04588491 0,08266729 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04588491 0,08260637 ! mitochondrion localization GO:0051646 18 9 0,000 0,04588491 0,08254554 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,04651365 0,08361505 ! gonad development GO:0008406 115 66 1,000 0,04651365 0,08355357 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,04906833 0,08807784 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 142 68 1,000 0,04906833 0,08801317 ! adaptive immune response GO:0002250 126 68 1,000 0,04906833 0,0879486 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,04906833 0,08788412 ! cellular hormone metabolic process GO:0034754 120 69 1,000 0,05036441 0,09013938 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,05036441 0,09007339 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,05036441 0,0900075 ! single fertilization GO:0007338 83 69 1,000 0,05036441 0,08994171 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05085217 0,09074641 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05085217 0,09068018 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05085217 0,09061403 ! associative learning GO:0008306 21 10 0,000 0,05085217 0,09054799 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05085217 0,09048204 ! phosphate transport GO:0006817 24 10 0,000 0,05085217 0,09041619 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05085217 0,09035043 ! CTP metabolic process GO:0046036 11 10 0,000 0,05085217 0,09028477 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,05085217 0,0902192 ! GTP metabolic process GO:0046039 11 10 0,000 0,05085217 0,09015373 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05085217 0,09008835 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05085217 0,09002307 ! social behavior GO:0035176 29 10 0,000 0,05085217 0,08995789 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05085217 0,08989279 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05085217 0,08982779 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05085217 0,08976289 ! androgen metabolic process GO:0008209 17 10 0,000 0,05085217 0,08969808 ! phospholipid efflux GO:0033700 19 10 0,000 0,05085217 0,08963336 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05085217 0,08956874 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05085217 0,08950421 ! pathogenesis GO:0009405 17 10 0,000 0,05085217 0,08943977 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05085217 0,08937542 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,05085217 0,08931117 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05085217 0,08924701 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,05085217 0,08918294 ! endoderm development GO:0007492 18 10 0,000 0,05085217 0,08911897 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05085217 0,08905508 ! arginine catabolic process GO:0006527 17 10 0,000 0,05085217 0,08899129 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05085217 0,08892759 ! proline metabolic process GO:0006560 13 10 0,000 0,05085217 0,08886398 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05085217 0,08880046 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05085217 0,08873703 ! V(D)J recombination GO:0033151 34 10 0,000 0,05085217 0,08867369 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05085217 0,08861044 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,05085217 0,08854728 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05085217 0,08848422 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05085217 0,08842124 ! multicellular organism growth GO:0035264 19 10 0,000 0,05085217 0,08835835 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05085217 0,08829555 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05085217 0,08823284 ! ruffle organization GO:0031529 17 10 0,000 0,05085217 0,08817022 ! epithelial cell development GO:0002064 21 10 0,000 0,05085217 0,08810769 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05085217 0,08804524 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05085217 0,08798289 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05085217 0,08792062 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05085217 0,08785844 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05085217 0,08779635 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05085217 0,08773435 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,05085217 0,08767243 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,05085217 0,08761061 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,05085217 0,08754887 ! segment specification GO:0007379 15 10 0,000 0,05085217 0,08748721 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05085217 0,08742564 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05085217 0,08736416 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05085217 0,08730277 ! response to dsRNA GO:0043331 23 10 0,000 0,05085217 0,08724146 ! DNA ligation GO:0006266 18 10 0,000 0,05085217 0,08718024 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05085217 0,0871191 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05085217 0,08705805 ! melanosome localization GO:0032400 16 10 0,000 0,05085217 0,08699709 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05085217 0,08693621 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05085217 0,08687541 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05085217 0,0868147 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05085217 0,08675408 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05085217 0,08669354 ! induction of an organ GO:0001759 17 10 0,000 0,05085217 0,08663308 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05085217 0,08657271 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05085217 0,08651242 ! protein sumoylation GO:0016925 17 10 0,000 0,05085217 0,08645222 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05085217 0,0863921 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05085217 0,08633206 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05085217 0,08627211 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05085217 0,08621224 ! salivary gland development GO:0007431 28 10 0,000 0,05085217 0,08615246 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05085217 0,08609275 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05085217 0,08603313 ! midbrain development GO:0030901 14 10 0,000 0,05085217 0,08597359 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05085217 0,08591414 GO:0050879|multicellular organismal movement, ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05085217 0,08585476 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05085217 0,08579547 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05085217 0,08573626 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05085217 0,08567713 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05085217 0,08561808 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05085217 0,08555912 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05085217 0,08550023 ! detection of calcium ion GO:0005513 24 10 0,000 0,05085217 0,08544143 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05085217 0,08538271 ! blastocyst formation GO:0001825 18 10 0,000 0,05085217 0,08532407 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05085217 0,0852655 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05085217 0,08520702 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05085217 0,08514862 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05085217 0,0850903 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05085217 0,08503206 ! germ cell development GO:0007281 133 70 1,000 0,05167277 0,08634512 ! B cell activation GO:0042113 179 72 1,000 0,05432566 0,09071605 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,05432566 0,09065409 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,05432566 0,09059221 ! humoral immune response GO:0006959 115 73 1,000 0,05566988 0,09277047 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,0557937 0,09291343 ! respiratory burst GO:0045730 17 11 0,000 0,0557937 0,09285014 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,0557937 0,09278693 ! neuron fate specification GO:0048665 18 11 0,000 0,0557937 0,09272381 ! telencephalon cell migration GO:0022029 23 11 0,000 0,0557937 0,09266077 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,0557937 0,09259783 ! thyroid gland development GO:0030878 26 11 0,000 0,0557937 0,09253496 ! synapsis GO:0007129 14 11 0,000 0,0557937 0,09247218 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,0557937 0,09240949 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,0557937 0,09234688 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,0557937 0,09228436 ! response to pain GO:0048265 27 11 0,000 0,0557937 0,09222192 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,0557937 0,09215957 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,0557937 0,0920973 ! bone resorption GO:0045453 16 11 0,000 0,0557937 0,09203511 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,0557937 0,09197301 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,0557937 0,09191099 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,0557937 0,09184906 ! melanocyte differentiation GO:0030318 20 11 0,000 0,0557937 0,09178721 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,0557937 0,09172544 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,0557937 0,09166375 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,0557937 0,09160215 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,0557937 0,09154063 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,0557937 0,09147919 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,0557937 0,09141784 ! UV protection GO:0009650 20 11 0,000 0,0557937 0,09135657 ! adult heart development GO:0007512 16 11 0,000 0,0557937 0,09129538 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,0557937 0,09123427 ! macroautophagy GO:0016236 19 11 0,000 0,0557937 0,09117324 ! temperature homeostasis GO:0001659 18 11 0,000 0,0557937 0,0911123 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,0557937 0,09105144 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,0557937 0,09099065 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,0557937 0,09092995 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,0557937 0,09086933 ! regulation of organ growth GO:0046620 14 11 0,000 0,0557937 0,09080879 ! pigment granule localization GO:0051875 20 11 0,000 0,0557937 0,09074834 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,0557937 0,09068796 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,0557937 0,09062766 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,0557937 0,09056744 ! embryonic axis specification GO:0000578 19 11 0,000 0,0557937 0,0905073 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,0557937 0,09044725 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,0557937 0,09038727 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,0557937 0,09032737 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,0557937 0,09026755 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,0557937 0,09020781 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,0557937 0,09014815 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,0557937 0,09008857 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,0557937 0,09002906 ! prophase GO:0051324 17 11 0,000 0,0557937 0,08996964 ! neuroblast proliferation GO:0007405 25 11 0,000 0,0557937 0,08991029 ! nucleosome positioning GO:0016584 15 11 0,000 0,0557937 0,08985102 ! regulation of isotype switching GO:0045191 24 11 0,000 0,0557937 0,08979183 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,0557937 0,08973272 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,0557937 0,08967368 ! apical protein localization GO:0045176 18 11 0,000 0,0557937 0,08961473 ! acid secretion GO:0046717 20 11 0,000 0,0557937 0,08955585 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,0557937 0,08949705 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,0557937 0,08943832 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,0557937 0,08937967 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,0557937 0,0893211 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,0557937 0,08926261 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,0557937 0,08920419 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,0557937 0,08914585 ! germ cell migration GO:0008354 26 11 0,000 0,0557937 0,08908758 ! embryonic gut development GO:0048566 19 11 0,000 0,0557937 0,08902939 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,0557937 0,08897128 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,0557937 0,08891324 ! activation of innate immune response GO:0002218 16 11 0,000 0,0557937 0,08885528 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,0557937 0,08879739 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,0557937 0,08873958 ! lysogeny GO:0030069 22 11 0,000 0,0557937 0,08868185 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,0557937 0,08862419 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,0557937 0,0885666 ! sequestering of metal ion GO:0051238 15 11 0,000 0,0557937 0,08850909 ! nucleus localization GO:0051647 22 11 0,000 0,0557937 0,08845165 ! acute inflammatory response GO:0002526 118 74 1,000 0,05702574 0,09034622 ! amino acid transport GO:0006865 148 74 1,000 0,05702574 0,09028767 ! regulation of caspase activity GO:0043281 136 74 1,000 0,05702574 0,09022919 ! organelle localization GO:0051640 155 74 1,000 0,05702574 0,09017079 ! reproductive structure development GO:0048608 131 75 1,000 0,05839308 0,09227315 ! axon guidance GO:0007411 162 75 1,000 0,05839308 0,0922135 ! rhythmic process GO:0048511 142 75 1,000 0,05839308 0,09215393 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,05977175 0,0942688 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,05977175 0,09420798 ! regulation of blood pressure GO:0008217 134 76 1,000 0,05977175 0,09414724 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,05977175 0,09408658 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06070964 0,09550138 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06070964 0,09543993 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06070964 0,09537855 ! mating GO:0007618 17 12 0,000 0,06070964 0,09531725 ! protein complex disassembly GO:0043241 28 12 0,000 0,06070964 0,09525603 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06070964 0,09519489 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,06070964 0,09513383 ! hippocampus development GO:0021766 29 12 0,000 0,06070964 0,09507285 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,06070964 0,09501194 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06070964 0,09495112 ! T cell proliferation GO:0042098 32 12 0,000 0,06070964 0,09489037 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06070964 0,0948297 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06070964 0,0947691 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06070964 0,09470859 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06070964 0,09464815 ! drug transport GO:0015893 16 12 0,000 0,06070964 0,09458778 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06070964 0,0945275 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06070964 0,09446729 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06070964 0,09440716 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06070964 0,0943471 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06070964 0,09428712 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06070964 0,09422722 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06070964 0,09416739 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06070964 0,09410764 ! lipid digestion GO:0044241 21 12 0,000 0,06070964 0,09404797 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06070964 0,09398837 ! entry into host cell GO:0030260 34 12 0,000 0,06070964 0,09392884 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06070964 0,0938694 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06070964 0,09381002 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06070964 0,09375072 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06070964 0,0936915 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06070964 0,09363235 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06070964 0,09357328 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06070964 0,09351428 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06070964 0,09345535 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06070964 0,0933965 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06070964 0,09333773 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06070964 0,09327902 ! fucose catabolic process GO:0019317 25 12 0,000 0,06070964 0,09322039 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06070964 0,09316184 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06070964 0,09310336 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,06070964 0,09304495 ! zymogen activation GO:0031638 18 12 0,000 0,06070964 0,09298661 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06070964 0,09292835 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06070964 0,09287016 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06070964 0,09281204 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06070964 0,092754 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06070964 0,09269603 ! defense response to fungus GO:0050832 15 12 0,000 0,06070964 0,09263813 ! developmental induction GO:0031128 22 12 0,000 0,06070964 0,0925803 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,06070964 0,09252255 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06070964 0,09246487 ! response to cold GO:0009409 17 12 0,000 0,06070964 0,09240726 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06070964 0,09234972 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06070964 0,09229225 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,06116159 0,09292149 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,06116159 0,09286374 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,06116159 0,09280606 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,06116159 0,09274845 ! regulation of catabolic process GO:0009894 173 77 1,000 0,06116159 0,09269092 ! fertilization GO:0009566 99 78 1,000 0,06256245 0,09475516 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,06256245 0,09469645 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,06397419 0,09677333 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,06397419 0,09671345 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,06397419 0,09665364 ! protein oligomerization GO:0051259 149 79 1,000 0,06397419 0,0965939 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,06539664 0,09868066 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,06539664 0,09861975 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,06560012 0,09886558 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06560012 0,09880462 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,06560012 0,09874375 ! regulation of chemokine production GO:0032642 18 13 0,000 0,06560012 0,09868294 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,06560012 0,09862222 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,06560012 0,09856156 ! peroxisomal transport GO:0043574 28 13 0,000 0,06560012 0,09850098 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,06560012 0,09844048 ! cartilage condensation GO:0001502 22 13 0,000 0,06560012 0,09838005 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,06560012 0,09831969 ! organelle fusion GO:0048284 36 13 0,000 0,06560012 0,09825941 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,06560012 0,0981992 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,06560012 0,09813907 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,06560012 0,09807901 ! endocrine pancreas development GO:0031018 25 13 0,000 0,06560012 0,09801902 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,06560012 0,09795911 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,06560012 0,09789927 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,06560012 0,0978395 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,06560012 0,09777981 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,06560012 0,09772018 ! methionine metabolic process GO:0006555 31 13 0,000 0,06560012 0,09766063 ! plasma membrane organization GO:0007009 27 13 0,000 0,06560012 0,09760116 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,06560012 0,09754175 ! Golgi organization GO:0007030 25 13 0,000 0,06560012 0,09748242 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,06560012 0,09742316 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,06560012 0,09736397 ! cytokine metabolic process GO:0042107 24 13 0,000 0,06560012 0,09730486 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,06560012 0,09724581 ! exocrine system development GO:0035272 34 13 0,000 0,06560012 0,09718684 ! asymmetric protein localization GO:0008105 24 13 0,000 0,06560012 0,09712794 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,06560012 0,09706911 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,06560012 0,09701035 ! L-glutamate transport GO:0015813 30 13 0,000 0,06560012 0,09695166 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,06560012 0,09689305 ! protein homotetramerization GO:0051289 24 13 0,000 0,06560012 0,0968345 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,06560012 0,09677603 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,06560012 0,09671762 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,06560012 0,09665929 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,06560012 0,09660103 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,06560012 0,09654283 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06560012 0,09648471 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,06560012 0,09642666 ! chromatin silencing GO:0006342 29 13 0,000 0,06560012 0,09636867 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,06560012 0,09631076 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,06560012 0,09625291 ! regulation of epidermis development GO:0045682 19 13 0,000 0,06560012 0,09619514 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,06560012 0,09613743 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,06560012 0,0960798 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,06560012 0,09602223 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,06560012 0,09596473 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,06560012 0,0959073 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,06560012 0,09584994 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,06560012 0,09579265 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,06560012 0,09573542 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,06560012 0,09567827 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,06560012 0,09562118 ! insulin secretion GO:0030073 24 13 0,000 0,06560012 0,09556416 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,06560012 0,09550721 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,06560012 0,09545033 ! acrosome reaction GO:0007340 19 13 0,000 0,06560012 0,09539351 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,06560012 0,09533676 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,06560012 0,09528008 ! meiosis GO:0007126 143 81 1,000 0,06682967 0,09700825 GO:0051327|M phase of meiotic cell cycle, ! regulation of peptidase activity GO:0052547 150 82 1,000 0,06827312 0,09904468 ! meiotic cell cycle GO:0051321 144 82 1,000 0,06827312 0,0989859 ! response to drug GO:0042493 149 83 1,000 0,06972686 0,10103364 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,06972686 0,10097375 ! rRNA transcription GO:0009303 28 14 0,000 0,07046528 0,10198263 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07046528 0,10192225 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07046528 0,10186194 ! water transport GO:0006833 21 14 0,000 0,07046528 0,10180171 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07046528 0,10174154 ! non-recombinational repair GO:0000726 29 14 0,000 0,07046528 0,10168144 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07046528 0,10162142 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07046528 0,10156147 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07046528 0,10150158 ! lipid localization GO:0010876 32 14 0,000 0,07046528 0,10144177 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,07046528 0,10138203 ! regulated secretory pathway GO:0045055 24 14 0,000 0,07046528 0,10132236 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07046528 0,10126276 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07046528 0,10120322 ! arginine metabolic process GO:0006525 21 14 0,000 0,07046528 0,10114376 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07046528 0,10108437 ! organic alcohol transport GO:0015850 29 14 0,000 0,07046528 0,10102505 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07046528 0,1009658 ! embryo implantation GO:0007566 30 14 0,000 0,07046528 0,10090662 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07046528 0,1008475 ! bone mineralization GO:0030282 18 14 0,000 0,07046528 0,10078846 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07046528 0,10072948 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07046528 0,10067058 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07046528 0,10061174 ! regulation of cellular pH GO:0030641 27 14 0,000 0,07046528 0,10055297 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07046528 0,10049427 ! ribosome assembly GO:0042255 18 14 0,000 0,07046528 0,10043564 ! cerebellum development GO:0021549 23 14 0,000 0,07046528 0,10037708 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07046528 0,10031858 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07046528 0,10026015 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07046528 0,1002018 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07046528 0,10014351 ! NADP metabolic process GO:0006739 24 14 0,000 0,07046528 0,10008528 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07046528 0,10002713 ! oxygen transport GO:0015671 22 14 0,000 0,07046528 0,09996904 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07046528 0,09991102 ! male genitalia development GO:0030539 26 14 0,000 0,07046528 0,09985307 ! regulation of axon extension GO:0030516 43 14 0,000 0,07046528 0,09979518 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07046528 0,09973736 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,07046528 0,09967961 ! response to metal ion GO:0010038 158 84 1,000 0,07119073 0,10064754 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,07414829 0,10476824 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,07414829 0,10470768 GO:0002696|positive regulation of leukocyte activation, ! lactation GO:0007595 30 15 0,000 0,07530525 0,10628002 ! reproductive cellular process GO:0048610 22 15 0,000 0,07530525 0,10621866 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,07530525 0,10615737 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,07530525 0,10609615 ! superoxide anion generation GO:0042554 22 15 0,000 0,07530525 0,106035 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,07530525 0,10597392 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,07530525 0,10591291 ! copper ion transport GO:0006825 22 15 0,000 0,07530525 0,10585197 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,07530525 0,1057911 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,07530525 0,1057303 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,07530525 0,10566957 ! sulfate transport GO:0008272 27 15 0,000 0,07530525 0,10560891 ! response to cAMP GO:0051591 25 15 0,000 0,07530525 0,10554832 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,07530525 0,1054878 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,07530525 0,10542735 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,07530525 0,10536696 ! response to hexose stimulus GO:0009746 25 15 0,000 0,07530525 0,10530665 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,07530525 0,10524641 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,07530525 0,10518623 ! vesicle coating GO:0006901 38 15 0,000 0,07530525 0,10512612 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,07530525 0,10506609 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,07530525 0,10500612 ! regulation of exocytosis GO:0017157 26 15 0,000 0,07530525 0,10494622 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,07530525 0,10488638 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,07530525 0,10482662 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,07530525 0,10476692 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,07530525 0,1047073 ! regulation of vasodilation GO:0042312 27 15 0,000 0,07530525 0,10464773 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,07530525 0,10458824 ! histone deacetylation GO:0016575 24 15 0,000 0,07530525 0,10452882 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,07530525 0,10446946 ! cofactor transport GO:0051181 30 15 0,000 0,07530525 0,10441017 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,07530525 0,10435095 ! muscle maintenance GO:0046716 26 15 0,000 0,07530525 0,10429179 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,07530525 0,1042327 ! intestinal absorption GO:0050892 31 15 0,000 0,07530525 0,10417368 ! dopamine metabolic process GO:0042417 35 15 0,000 0,07530525 0,10411472 ! heme biosynthetic process GO:0006783 33 15 0,000 0,07530525 0,10405584 ! cell killing GO:0001906 32 15 0,000 0,07530525 0,10399701 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,07530525 0,10393826 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,07530525 0,10387957 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,07530525 0,10382095 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,07530525 0,10376239 ! actin filament polymerization GO:0030041 27 15 0,000 0,07530525 0,1037039 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,0771447 0,10617718 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,07865711 0,10819781 ! protein localization in nucleus GO:0034504 192 89 1,000 0,07865711 0,10813693 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,08012015 0,11008634 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,08012015 0,11002446 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,08012015 0,10996265 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,08012015 0,10990091 ! bone remodeling GO:0046849 28 16 0,000 0,08012015 0,10983923 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,08012015 0,10977763 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08012015 0,1097161 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,08012015 0,10965463 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,08012015 0,10959323 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,08012015 0,10953191 ! startle response GO:0001964 28 16 0,000 0,08012015 0,10947065 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,08012015 0,10940945 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,08012015 0,10934833 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,08012015 0,10928728 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,08012015 0,10922629 ! protein polyubiquitination GO:0000209 41 16 0,000 0,08012015 0,10916537 ! glutamate metabolic process GO:0006536 25 16 0,000 0,08012015 0,10910452 ! pituitary gland development GO:0021983 30 16 0,000 0,08012015 0,10904374 ! response to osmotic stress GO:0006970 27 16 0,000 0,08012015 0,10898303 ! lysosomal transport GO:0007041 31 16 0,000 0,08012015 0,10892238 ! fructose metabolic process GO:0006000 25 16 0,000 0,08012015 0,1088618 ! L-amino acid transport GO:0015807 33 16 0,000 0,08012015 0,10880129 ! stem cell development GO:0048864 46 16 0,000 0,08012015 0,10874084 GO:0019827|stem cell maintenance, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08012015 0,10868046 ! intermediate filament-based process GO:0045103 36 16 0,000 0,08012015 0,10862015 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,08012015 0,10855991 ! negative regulation of immune response GO:0050777 38 16 0,000 0,08012015 0,10849973 ! axon cargo transport GO:0008088 46 16 0,000 0,08012015 0,10843962 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,08012015 0,10837958 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,08012015 0,1083196 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,08012015 0,10825969 ! neuron recognition GO:0008038 40 16 0,000 0,08012015 0,10819984 ! mRNA splice site selection GO:0006376 44 16 0,000 0,08012015 0,10814006 ! tissue regeneration GO:0042246 27 16 0,000 0,08012015 0,10808035 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,08012015 0,1080207 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,08012015 0,10796112 ! biomineral formation GO:0031214 22 16 0,000 0,08012015 0,10790161 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,08012015 0,10784216 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,08012015 0,10778277 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08012015 0,10772345 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,08012015 0,1076642 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,08012015 0,10760501 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,08012015 0,10754589 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,08012015 0,10748683 ! peptide hormone processing GO:0016486 27 16 0,000 0,08012015 0,10742783 ! response to inorganic substance GO:0010035 173 90 1,000 0,08017881 0,10744753 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,08170967 0,109439 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! amine transport GO:0015837 181 93 1,000 0,08479832 0,11351359 ! vitamin metabolic process GO:0006766 153 93 1,000 0,08479832 0,11345142 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,08491011 0,1135388 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,08491011 0,11347669 ! filopodium assembly GO:0046847 42 17 0,000 0,08491011 0,11341465 ! endothelial cell migration GO:0043542 31 17 0,000 0,08491011 0,11335267 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08491011 0,11329077 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08491011 0,11322893 ! glial cell development GO:0021782 28 17 0,000 0,08491011 0,11316715 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,08491011 0,11310545 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08491011 0,11304381 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,08491011 0,11298224 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08491011 0,11292074 ! myoblast differentiation GO:0045445 50 17 0,000 0,08491011 0,1128593 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08491011 0,11279793 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,08491011 0,11273663 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08491011 0,11267539 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08491011 0,11261422 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,08491011 0,11255312 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,08491011 0,11249208 ! membrane budding GO:0006900 42 17 0,000 0,08491011 0,11243111 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08491011 0,1123702 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08491011 0,11230936 ! genitalia development GO:0048806 32 17 0,000 0,08491011 0,11224859 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08491011 0,11218788 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,08491011 0,11212724 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08491011 0,11206666 ! steroid catabolic process GO:0006706 34 17 0,000 0,08491011 0,11200615 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,08491011 0,11194571 ! gas transport GO:0015669 26 17 0,000 0,08491011 0,11188532 ! organic cation transport GO:0015695 32 17 0,000 0,08491011 0,11182501 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08491011 0,11176476 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,08491011 0,11170457 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,08792198 0,11560462 ! sex differentiation GO:0007548 171 96 1,000 0,08949661 0,11761173 ! response to protein stimulus GO:0051789 158 96 1,000 0,08949661 0,1175485 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,08967526 0,11771986 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,08967526 0,11765664 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,08967526 0,11759349 ! limbic system development GO:0021761 40 18 0,000 0,08967526 0,1175304 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,08967526 0,11746738 ! adult walking behavior GO:0007628 36 18 0,000 0,08967526 0,11740443 ! heart looping GO:0001947 34 18 0,000 0,08967526 0,11734154 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,08967526 0,11727873 ! centrosome cycle GO:0007098 26 18 0,000 0,08967526 0,11721598 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,08967526 0,1171533 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,08967526 0,11709068 ! glycine metabolic process GO:0006544 30 18 0,000 0,08967526 0,11702813 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,08967526 0,11696565 ! DNA integration GO:0015074 32 18 0,000 0,08967526 0,11690324 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,08967526 0,11684089 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,08967526 0,11677861 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,08967526 0,11671639 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,08967526 0,11665424 ! neural crest cell migration GO:0001755 41 18 0,000 0,08967526 0,11659216 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,08967526 0,11653014 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,08967526 0,11646819 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,08967526 0,1164063 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,08967526 0,11634448 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,08967526 0,11628273 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,08967526 0,11622104 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,08967526 0,11615942 ! detection of bacterium GO:0016045 22 18 0,000 0,08967526 0,11609786 ! microspike assembly GO:0030035 46 18 0,000 0,08967526 0,11603637 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,08967526 0,11597494 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,08967526 0,11591358 ! leukocyte differentiation GO:0002521 232 98 1,000 0,09267082 0,11972227 ! forebrain development GO:0030900 210 98 1,000 0,09267082 0,11965899 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,09267082 0,11959578 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,09441574 0,12178334 ! positive regulation of translation GO:0045727 31 19 0,000 0,09441574 0,12171907 ! negative regulation of defense response GO:0031348 27 19 0,000 0,09441574 0,12165487 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,09441574 0,12159074 ! neuron maturation GO:0042551 46 19 0,000 0,09441574 0,12152668 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,09441574 0,12146269 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,09441574 0,12139876 GO:0019692|deoxyribose phosphate metabolic process, ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,09441574 0,1213349 ! inositol metabolic process GO:0006020 33 19 0,000 0,09441574 0,1212711 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,09441574 0,12120738 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,09441574 0,12114372 GO:0042744|hydrogen peroxide catabolic process, ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,09441574 0,12108013 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,09441574 0,1210166 ! cerebral cortex development GO:0021987 40 19 0,000 0,09441574 0,12095314 ! pigmentation during development GO:0048066 42 19 0,000 0,09441574 0,12088975 ! heme metabolic process GO:0042168 40 19 0,000 0,09441574 0,12082642 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,09441574 0,12076316 ! response to fungus GO:0009620 26 19 0,000 0,09441574 0,12069997 ! protein export from nucleus GO:0006611 40 19 0,000 0,09441574 0,12063684 ! heart process GO:0003015 32 19 0,000 0,09441574 0,12057378 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,09441574 0,12051078 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,09441574 0,12044785 ! visual learning GO:0008542 38 19 0,000 0,09441574 0,12038499 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,09441574 0,12032219 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,09441574 0,12025946 ! vitamin transport GO:0051180 31 19 0,000 0,09441574 0,12019679 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,09441574 0,12013419 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,09441574 0,12007165 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,09441574 0,12000918 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,09441574 0,11994677 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,09441574 0,11988443 ! cilium assembly GO:0042384 38 19 0,000 0,09441574 0,11982215 ! protein secretion GO:0009306 45 20 0,000 0,09913166 0,12574176 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,09913166 0,12567651 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,09913166 0,12561133 ! positive regulation of ossification GO:0045778 50 20 0,000 0,09913166 0,12554621 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,09913166 0,12548116 ! skin development GO:0043588 42 20 0,000 0,09913166 0,12541618 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,09913166 0,12535126 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,09913166 0,12528641 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,09913166 0,12522163 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,09913166 0,12515692 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,09913166 0,12509227 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,09913166 0,12502769 ! bile acid metabolic process GO:0008206 34 20 0,000 0,09913166 0,12496318 ! retinoid metabolic process GO:0001523 34 20 0,000 0,09913166 0,12489873 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,09913166 0,12483435 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,09913166 0,12477003 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,09913166 0,12470579 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,09913166 0,1246416 GO:0030968|endoplasmic reticulum unfolded protein response, ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,09913166 0,12457749 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,09913166 0,12451344 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,09913166 0,12444945 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,09913166 0,12438553 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,09913166 0,12432168 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,09913166 0,12425789 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,09913166 0,12419417 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,09913166 0,12413052 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,09913166 0,12406692 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,09913166 0,1240034 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,09913166 0,12393994 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,09913166 0,12387654 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,09913166 0,12381321 ! regulation of cell killing GO:0031341 46 21 0,000 0,10382315 0,12960652 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,10382315 0,12954033 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,10382315 0,1294742 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,10382315 0,12940814 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,10382315 0,12934215 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,10382315 0,12927623 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,10382315 0,12921037 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,10382315 0,12914458 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,10382315 0,12907886 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,10382315 0,1290132 ! diencephalon development GO:0021536 36 21 0,000 0,10382315 0,12894761 ! collagen fibril organization GO:0030199 62 21 0,000 0,10382315 0,12888209 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,10382315 0,12881664 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,10382315 0,12875125 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,10382315 0,12868592 ! collagen catabolic process GO:0030574 29 21 0,000 0,10382315 0,12862067 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,10382315 0,12855548 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,10382315 0,12849035 ! sperm-egg recognition GO:0035036 23 21 0,000 0,10382315 0,12842529 ! actin filament-based movement GO:0030048 47 21 0,000 0,10382315 0,1283603 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,10382315 0,12829538 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,10849034 0,1339949 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,10849034 0,13392719 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,10849034 0,13385955 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,10849034 0,13379198 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,10849034 0,13372448 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,10849034 0,13365704 ! microtubule-based transport GO:0010970 59 22 0,000 0,10849034 0,13358967 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,10849034 0,13352237 ! cellular response to starvation GO:0009267 37 22 0,000 0,10849034 0,13345514 ! vacuolar transport GO:0007034 41 22 0,000 0,10849034 0,13338798 ! central nervous system neuron development GO:0021954 47 22 0,000 0,10849034 0,13332088 ! fucose metabolic process GO:0006004 44 22 0,000 0,10849034 0,13325385 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,10849034 0,13318689 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,10849034 0,13312 ! stem cell differentiation GO:0048863 57 22 0,000 0,10849034 0,13305317 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,10849034 0,13298641 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,10849034 0,13291971 ! cytolysis GO:0019835 27 22 0,000 0,10849034 0,13285309 ! vasodilation GO:0042311 40 22 0,000 0,10849034 0,13278653 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,10849034 0,13272004 ! G1 phase GO:0051318 44 22 0,000 0,10849034 0,13265361 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,10849034 0,13258725 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,10849034 0,13252096 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,10849034 0,13245473 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,10849034 0,13238857 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,10849034 0,13232247 ! sarcomere organization GO:0045214 32 22 0,000 0,10849034 0,13225644 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,10849034 0,13219048 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,10849034 0,13212458 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,10849034 0,13205875 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,10849034 0,13199298 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,10849034 0,13192728 ! protein stabilization GO:0050821 41 22 0,000 0,10849034 0,13186165 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11313336 0,1374365 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11313336 0,13736819 ! gluconeogenesis GO:0006094 38 23 0,000 0,11313336 0,13729995 ! glycerol metabolic process GO:0006071 40 23 0,000 0,11313336 0,13723178 ! viral genome replication GO:0019079 44 23 0,000 0,11313336 0,13716367 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,11313336 0,13709564 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11313336 0,13702767 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11313336 0,13695976 ! axis specification GO:0009798 43 23 0,000 0,11313336 0,13689193 ! visual behavior GO:0007632 46 23 0,000 0,11313336 0,13682416 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,11313336 0,13675646 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11313336 0,13668882 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11313336 0,13662126 ! peroxisome organization GO:0007031 43 23 0,000 0,11313336 0,13655376 ! lysosome organization GO:0007040 47 23 0,000 0,11313336 0,13648632 ! vesicle targeting GO:0006903 49 23 0,000 0,11313336 0,13641896 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,11313336 0,13635165 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11313336 0,13628442 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11313336 0,13621725 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11313336 0,13615015 ! DNA modification GO:0006304 36 23 0,000 0,11313336 0,13608311 ! fatty acid transport GO:0015908 47 23 0,000 0,11313336 0,13601614 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,11313336 0,13594924 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,11313336 0,1358824 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11313336 0,13581563 ! cell-cell recognition GO:0009988 28 23 0,000 0,11313336 0,13574892 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,11313336 0,13568228 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,11313336 0,1356157 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11313336 0,13554919 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,11775233 0,14101419 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,11775233 0,1409451 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,11775233 0,14087607 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,11775233 0,14080712 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,11775233 0,14073823 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,11775233 0,14066941 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,11775233 0,14060065 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,11775233 0,14053197 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,11775233 0,14046335 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,11775233 0,1403948 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,11775233 0,14032631 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,11775233 0,14025789 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,11775233 0,14018954 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,11775233 0,14012126 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,11775233 0,14005304 ! pallium development GO:0021543 56 24 0,000 0,11775233 0,13998489 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,11775233 0,1399168 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,11775233 0,13984878 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,11775233 0,13978083 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,11775233 0,13971294 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,11775233 0,13964512 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,11775233 0,13957736 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,11775233 0,13950967 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,11775233 0,13944205 ! regulation of amine transport GO:0051952 41 24 0,000 0,11775233 0,13937449 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,11775233 0,13930699 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,12234737 0,1446731 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,12234737 0,14460311 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,12234737 0,14453318 ! phototransduction GO:0007602 37 25 0,000 0,12234737 0,14446333 ! keratinization GO:0031424 37 25 0,000 0,12234737 0,14439354 ! vacuole organization GO:0007033 49 25 0,000 0,12234737 0,14432382 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,12234737 0,14425416 ! receptor metabolic process GO:0043112 53 25 0,000 0,12234737 0,14418457 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,12234737 0,14411505 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,12234737 0,1440456 ! immunoglobulin production GO:0002377 62 25 0,000 0,12234737 0,14397622 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,12234737 0,1439069 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,12234737 0,14383764 ! liver development GO:0001889 55 25 0,000 0,12234737 0,14376846 ! initiation of viral infection GO:0019059 60 26 0,000 0,12691861 0,14906834 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,12691861 0,14899671 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,12691861 0,14892515 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,12691861 0,14885365 ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,12691861 0,14878222 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,12691861 0,14871086 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,12691861 0,14863957 ! digestive system process GO:0022600 49 26 0,000 0,12691861 0,14856835 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,12691861 0,1484972 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,12691861 0,14842611 ! osteoblast differentiation GO:0001649 63 26 0,000 0,12691861 0,1483551 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,12691861 0,14828415 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,12691861 0,14821327 ! negative regulation of cell development GO:0010721 83 26 0,000 0,12691861 0,14814245 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,12691861 0,14807171 ! pentose metabolic process GO:0019321 43 26 0,000 0,12691861 0,14800103 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,12691861 0,14793042 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,12691861 0,14785987 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,12691861 0,1477894 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,12691861 0,14771899 ! blastocyst development GO:0001824 50 26 0,000 0,12691861 0,14764864 ! telomere organization GO:0032200 46 26 0,000 0,12691861 0,14757837 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,12691861 0,14750816 ! neural tube closure GO:0001843 58 26 0,000 0,12691861 0,14743802 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,12691861 0,14736794 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,12691861 0,14729793 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,13146616 0,15250324 ! embryonic pattern specification GO:0009880 49 27 0,000 0,13146616 0,15243086 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,13146616 0,15235855 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,13146616 0,15228631 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,13146616 0,15221414 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,13146616 0,15214203 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,13146616 0,15206999 ! iron ion transport GO:0006826 65 27 0,000 0,13146616 0,15199803 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,13146616 0,15192613 ! superoxide metabolic process GO:0006801 41 27 0,000 0,13146616 0,15185429 ! tube lumen formation GO:0035148 59 27 0,000 0,13146616 0,15178253 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,13146616 0,15171083 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,13146616 0,1516392 ! response to starvation GO:0042594 47 27 0,000 0,13146616 0,15156764 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,13146616 0,15149615 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,13146616 0,15142472 ! neuron fate commitment GO:0048663 52 28 0,000 0,13599016 0,15656171 ! vesicle docking GO:0048278 55 28 0,000 0,13599016 0,15648797 ! circadian rhythm GO:0007623 56 28 0,000 0,13599016 0,15641429 ! dendrite development GO:0016358 67 28 0,000 0,13599016 0,15634068 ! fat cell differentiation GO:0045444 57 28 0,000 0,13599016 0,15626715 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,13599016 0,15619368 ! sperm motility GO:0030317 37 28 0,000 0,13599016 0,15612028 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,13599016 0,15604695 ! base-excision repair GO:0006284 41 28 0,000 0,13599016 0,15597369 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,13599016 0,15590049 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,13599016 0,15582737 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,13599016 0,15575431 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,13599016 0,15568133 ! glutathione metabolic process GO:0006749 42 28 0,000 0,13599016 0,15560841 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,13599016 0,15553556 ! lipid oxidation GO:0034440 48 28 0,000 0,13599016 0,15546278 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,13599016 0,15539006 ! translational initiation GO:0006413 66 29 0,000 0,14049071 0,1604576 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,14049071 0,16038262 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,14049071 0,16030771 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,14049071 0,16023287 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,14049071 0,1601581 ! autophagy GO:0006914 47 29 0,000 0,14049071 0,1600834 ! primary neural tube formation GO:0014020 61 29 0,000 0,14049071 0,16000877 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,14049071 0,15993421 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,14049071 0,15985972 ! synaptogenesis GO:0007416 46 29 0,000 0,14049071 0,1597853 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,14049071 0,15971094 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,14049071 0,15963666 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,14049071 0,15956244 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,14496796 0,16457096 ! phenol metabolic process GO:0018958 56 30 0,000 0,14496796 0,16449453 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,14496796 0,16441816 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,14496796 0,16434186 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,14496796 0,16426564 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,14496796 0,16418948 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,14496796 0,1641134 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,14496796 0,16403739 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,14496796 0,16396144 ! myofibril assembly GO:0030239 50 30 0,000 0,14496796 0,16388557 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,14496796 0,16380977 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,14496796 0,16373403 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,14496796 0,16365837 ! cell fate determination GO:0001709 64 30 0,000 0,14496796 0,16358278 ! phospholipid transport GO:0015914 65 30 0,000 0,14496796 0,16350726 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,14496796 0,1634318 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,14496796 0,16335642 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,14496796 0,1632811 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,149422 0,16822025 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,149422 0,16814277 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,149422 0,16806535 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,149422 0,16798801 ! regulation of innate immune response GO:0045088 57 31 0,000 0,149422 0,16791074 ! iron ion homeostasis GO:0055072 60 31 0,000 0,149422 0,16783354 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,149422 0,16775641 ! detection of light stimulus GO:0009583 44 31 0,000 0,149422 0,16767935 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,149422 0,16760236 ! natural killer cell activation GO:0030101 50 31 0,000 0,149422 0,16752544 ! cofactor catabolic process GO:0051187 54 31 0,000 0,149422 0,1674486 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,149422 0,16737182 ! eye morphogenesis GO:0048592 65 31 0,000 0,149422 0,16729512 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,149422 0,16721848 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,15385297 0,17209835 ! collagen metabolic process GO:0032963 49 32 0,000 0,15385297 0,17201959 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,15385297 0,1719409 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,15385297 0,17186228 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,15385297 0,17178373 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,15385297 0,17170525 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,15385297 0,17162685 ! muscle cell development GO:0055001 52 32 0,000 0,15385297 0,17154852 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,15385297 0,17147025 ! BMP signaling pathway GO:0030509 71 32 0,000 0,15385297 0,17139206 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,15385297 0,17131395 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,15385297 0,1712359 ! gene silencing GO:0016458 71 32 0,000 0,15385297 0,17115792 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,15826098 0,17598159 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,15826098 0,17590153 GO:0055092|sterol homeostasis, ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,15826098 0,17582154 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,15826098 0,17574162 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,15826098 0,17566177 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,15826098 0,175582 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,15826098 0,1755023 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,15826098 0,17542267 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,15826098 0,17534311 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,15826098 0,17526363 ! glial cell differentiation GO:0010001 67 34 0,000 0,16264614 0,1800383 ! cholesterol transport GO:0030301 62 34 0,000 0,16264614 0,17995676 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,16264614 0,1798753 ! spliceosome assembly GO:0000245 75 34 0,000 0,16264614 0,1797939 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,16264614 0,17971259 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,16264614 0,17963134 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,16264614 0,17955017 ! adult locomotory behavior GO:0008344 62 34 0,000 0,16264614 0,17946907 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,16700859 0,18419954 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,16700859 0,18411642 ! membrane docking GO:0022406 69 35 0,000 0,16700859 0,18403337 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,16700859 0,1839504 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,16700859 0,1838675 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,16700859 0,18378468 ! ceramide metabolic process GO:0006672 72 35 0,000 0,16700859 0,18370193 ! telencephalon development GO:0021537 81 35 0,000 0,16700859 0,18361926 ! sterol transport GO:0015918 63 35 0,000 0,16700859 0,18353666 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,16700859 0,18345413 ! placenta development GO:0001890 53 35 0,000 0,16700859 0,18337168 ! vesicle localization GO:0051648 70 35 0,000 0,16700859 0,1832893 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,17134843 0,18796777 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,17134843 0,1878834 ! protein targeting to membrane GO:0006612 75 36 0,000 0,17134843 0,18779911 ! regulation of proteolysis GO:0030162 77 36 0,000 0,17134843 0,1877149 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,17134843 0,18763076 ! aerobic respiration GO:0009060 56 36 0,000 0,17134843 0,18754669 ! cytokine production GO:0001816 68 36 0,000 0,17134843 0,1874627 ! embryonic organ development GO:0048568 67 36 0,000 0,17134843 0,18737879 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,17134843 0,18729495 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,17134843 0,18721119 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,17566578 0,19184243 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,17566578 0,19175671 ! odontogenesis GO:0042476 74 37 0,000 0,17566578 0,19167106 ! actomyosin structure organization GO:0031032 68 37 0,000 0,17566578 0,19158549 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,17566578 0,1915 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,17566578 0,19141459 ! organic anion transport GO:0015711 82 38 0,000 0,17996076 0,1960072 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,17996076 0,19591985 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,17996076 0,19583258 ! spermatid development GO:0007286 69 38 0,000 0,17996076 0,19574539 ! glycogen metabolic process GO:0005977 63 38 0,000 0,17996076 0,19565827 ! neural tube formation GO:0001841 79 38 0,000 0,17996076 0,19557124 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,18423348 0,20012557 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,18423348 0,20003662 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,18423348 0,19994776 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,18423348 0,19985897 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,18423348 0,19977026 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,18423348 0,19968163 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,18423348 0,19959308 ! glucan metabolic process GO:0044042 64 39 0,000 0,18423348 0,19950461 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,18848406 0,20401709 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,18848406 0,20392673 ! lipid homeostasis GO:0055088 75 40 0,000 0,18848406 0,20383646 ! mismatch repair GO:0006298 58 40 0,000 0,18848406 0,20374627 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,18848406 0,20365615 ! RNA export from nucleus GO:0006405 61 41 0,000 0,19271261 0,20813303 ! mRNA catabolic process GO:0006402 79 41 0,000 0,19271261 0,20804106 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,19271261 0,20794917 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,19271261 0,20785736 ! gliogenesis GO:0042063 91 41 0,000 0,19271261 0,20776563 ! feeding behavior GO:0007631 69 41 0,000 0,19271261 0,20767398 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,19271261 0,20758241 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,19271261 0,20749093 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,19271261 0,20739952 ! RNA modification GO:0009451 64 41 0,000 0,19271261 0,2073082 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,19691925 0,2117402 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,19691925 0,21164704 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,19691925 0,21155397 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,19691925 0,21146098 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,20110408 0,21585996 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,20110408 0,21576516 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,20110408 0,21567044 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,20110408 0,21557581 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,20110408 0,21548126 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,20110408 0,21538679 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,20110408 0,21529241 ! ion transmembrane transport GO:0034220 79 43 0,000 0,20110408 0,2151981 ! neuron migration GO:0001764 85 43 0,000 0,20110408 0,21510388 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,20110408 0,21500975 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,20526722 0,21936475 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,20526722 0,21926884 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,20526722 0,219173 ! striated muscle contraction GO:0006941 85 44 0,000 0,20526722 0,21907725 ! phagocytosis GO:0006909 105 44 0,000 0,20526722 0,21898158 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,20526722 0,218886 ! double-strand break repair GO:0006302 85 44 0,000 0,20526722 0,2187905 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,20940879 0,22310758 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,20940879 0,22301032 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,20940879 0,22291315 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,20940879 0,22281606 ! polyol metabolic process GO:0019751 77 45 0,000 0,20940879 0,22271906 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,21352889 0,22700221 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,21352889 0,22690347 ! glycolysis GO:0006096 71 46 0,000 0,21352889 0,22680481 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,21352889 0,22670625 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,21352889 0,22660776 ! cell growth GO:0016049 90 46 0,000 0,21352889 0,22650937 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,21352889 0,22641106 ! neural tube development GO:0021915 91 47 0,000 0,21762763 0,23065696 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,22170513 0,23487668 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,22170513 0,23477487 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,22170513 0,23467315 ! response to calcium ion GO:0051592 94 49 0,000 0,22576149 0,23886328 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,22576149 0,23875988 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,22576149 0,23865656 ! protein homooligomerization GO:0051260 84 49 0,000 0,22576149 0,23855334 ! regulation of ion transport GO:0043269 86 50 0,000 0,22979682 0,24271233 ! endocrine system development GO:0035270 109 50 0,000 0,22979682 0,24260745 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,22979682 0,24250265 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,22979682 0,24239794 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,22979682 0,24229332 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,22979682 0,2421888 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,22979682 0,24208436 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,22979682 0,24198001 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,23381123 0,24610118 ! viral infectious cycle GO:0019058 104 51 0,000 0,23381123 0,24599519 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,23381123 0,2458893 ! Notch signaling pathway GO:0007219 111 52 0,000 0,23780483 0,24998159 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,23780483 0,24987407 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,23780483 0,24976664 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,23780483 0,24965931 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,23780483 0,24955207 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,23780483 0,24944492 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,23780483 0,24933786 ! amino acid activation GO:0043038 98 52 0,000 0,23780483 0,24923089 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,24177773 0,25328602 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,24177773 0,25317745 ! regulation of translational initiation GO:0006446 87 54 0,000 0,24573003 0,25720586 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,24573003 0,25709571 ! neuromuscular process GO:0050905 107 54 0,000 0,24573003 0,25698565 ! RNA catabolic process GO:0006401 103 55 0,000 0,24966184 0,26098583 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,24966184 0,2608742 ! cell recognition GO:0008037 98 55 0,000 0,24966184 0,26076267 ! cell maturation GO:0048469 107 55 0,000 0,24966184 0,26065123 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,24966184 0,26053989 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,25357327 0,26450875 ! glucose catabolic process GO:0006007 88 56 0,000 0,25357327 0,26439586 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,25357327 0,26428306 ! RNA elongation GO:0006354 90 56 0,000 0,25357327 0,26417036 ! chloride transport GO:0006821 102 57 0,000 0,25746441 0,26810979 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,25746441 0,26799555 ! regulation of actin filament length GO:0030832 118 58 0,000 0,26133538 0,271909 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,26133538 0,27179325 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,26133538 0,27167759 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,26133538 0,27156203 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,26133538 0,27144657 ! nuclear export GO:0051168 110 59 0,000 0,26518628 0,2753294 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,26901721 0,27918821 ! regulation of endocytosis GO:0030100 104 60 0,000 0,26901721 0,27906966 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,26901721 0,27895121 ! adult behavior GO:0030534 104 60 0,000 0,26901721 0,27883286 ! regulation of cellular component size GO:0032535 125 61 0,000 0,27282827 0,28266305 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,27282827 0,28254323 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,27282827 0,28242351 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,27282827 0,28230389 ! camera-type eye development GO:0043010 126 61 0,000 0,27282827 0,28218437 ! proton transport GO:0015992 117 61 0,000 0,27282827 0,28206495 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,27661958 0,28586363 ! tRNA processing GO:0008033 102 62 0,000 0,27661958 0,28574276 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,28039122 0,28951638 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,28039122 0,28939406 ! hydrogen transport GO:0006818 121 64 0,000 0,2841433 0,29314277 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,2841433 0,29301903 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,28787592 0,29674299 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,28787592 0,29661783 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,29158919 0,3003172 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,29158919 0,30019064 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,2952832 0,30386556 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,2952832 0,30373762 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,2952832 0,30360979 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,2952832 0,30348206 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,29895805 0,30712973 ! hexose catabolic process GO:0019320 113 68 0,000 0,29895805 0,30700063 ! extracellular matrix organization GO:0030198 146 68 0,000 0,29895805 0,30687164 ! detection of external stimulus GO:0009581 102 68 0,000 0,29895805 0,30674276 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,29895805 0,30661398 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,29895805 0,30648532 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,30261383 0,31010302 ! developmental maturation GO:0021700 128 69 0,000 0,30261383 0,309973 ! cell redox homeostasis GO:0045454 114 70 0,000 0,30625066 0,31356679 ! activation of immune response GO:0002253 120 70 0,000 0,30625066 0,31343543 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,30625066 0,31330417 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,30986863 0,31687277 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,30986863 0,31674019 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,30986863 0,31660772 ! appendage morphogenesis GO:0035107 150 72 0,000 0,31346782 0,32015129 GO:0035108|limb morphogenesis, ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,31346782 0,3200175 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,31346782 0,31988383 ! appendage development GO:0048736 151 73 0,000 0,31704835 0,32340255 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,31704835 0,32326758 ! regulation of immune effector process GO:0002697 156 73 0,000 0,31704835 0,32313271 ! transition metal ion transport GO:0000041 143 75 0,000 0,32415378 0,33023673 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,32415378 0,33009907 ! eye development GO:0001654 155 75 0,000 0,32415378 0,32996153 ! amine catabolic process GO:0009310 136 77 0,000 0,33118568 0,33697901 ! neurotransmitter transport GO:0006836 142 77 0,000 0,33118568 0,33683872 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,33118568 0,33669855 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,33118568 0,33655849 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,33467429 0,33996228 ! antigen processing and presentation GO:0019882 117 78 0,000 0,33467429 0,33982099 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,34159731 0,34670637 ! muscle cell differentiation GO:0042692 178 81 0,000 0,34503191 0,35004691 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,34503191 0,3499016 ! protein import into nucleus GO:0006606 174 82 0,000 0,34844869 0,35321997 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,35184773 0,35651763 ! exocytosis GO:0006887 153 83 0,000 0,35184773 0,35636982 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,35184773 0,35622213 ! nuclear import GO:0051170 177 83 0,000 0,35184773 0,35607457 ! inorganic anion transport GO:0015698 156 83 0,000 0,35184773 0,35592713 ! digestion GO:0007586 130 84 0,000 0,35522914 0,359199 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,35859301 0,36245044 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,35859301 0,36230054 ! regulation of lyase activity GO:0051339 169 86 0,000 0,36193941 0,36553038 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,36526846 0,36874002 ! alcohol catabolic process GO:0046164 142 87 0,000 0,36526846 0,36858771 ! nucleosome assembly GO:0006334 126 87 0,000 0,36526846 0,36843552 ! cellular respiration GO:0045333 143 88 0,000 0,36858022 0,37162257 ! amine biosynthetic process GO:0009309 146 88 0,000 0,36858022 0,37146926 ! sensory perception of smell GO:0007608 117 88 0,000 0,36858022 0,37131608 ! chromatin assembly GO:0031497 128 88 0,000 0,36858022 0,37116302 ! cellular defense response GO:0006968 123 89 0,000 0,3718748 0,37432639 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,37515229 0,37746995 ! response to unfolded protein GO:0006986 139 90 0,000 0,37515229 0,37731455 ! defense response to bacterium GO:0042742 112 91 0,000 0,37841276 0,38043719 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,38165631 0,38354026 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,38488303 0,38662387 GO:0010498|proteasomal protein catabolic process, ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,388093 0,38968812 ! sterol metabolic process GO:0016125 166 94 0,000 0,388093 0,38952802 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,388093 0,38936805 ! nucleosome organization GO:0034728 143 95 0,000 0,39128631 0,39241069 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,39128631 0,39224967 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,39128631 0,39208878 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,39128631 0,39192802 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,39762329 0,39811217 ! transcription initiation GO:0006352 171 97 0,000 0,39762329 0,39794907 ! mRNA transport GO:0051028 185 100 0,000 0,40700593 0,4071726 ! positive regulation of immune response GO:0050778 175 100 0,000 0,40700593 0,40700593