pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6893-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 1,883E-06 4,331E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 7,749E-06 8,911E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 1,313E-05 0,01006982 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,313E-05 7,552E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 1,498E-05 6,892E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 2,09E-05 8,013E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,09E-05 6,868E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 2,18E-05 6,266E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 3,079E-05 7,868E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 3,119E-05 7,173E-03 ! pyrimidine base metabolic process GO:0006206 14 9 2,000 3,119E-05 6,521E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 5,000 3,989E-05 7,645E-03 ! nucleobase biosynthetic process GO:0046112 21 10 2,000 4,431E-05 7,84E-03 ! interphase GO:0051325 159 88 5,000 4,543E-05 7,464E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 6,005E-05 9,207E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 6,06E-05 8,712E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 6,06E-05 8,199E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 6,06E-05 7,744E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 6,06E-05 7,336E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 6,06E-05 6,97E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of kinase activity GO:0033673 100 58 4,000 6,533E-05 7,155E-03 ! regulation of skeletal muscle fiber development GO:0048742 20 12 2,000 8,037E-05 8,403E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 8,335E-05 8,335E-03 ! regulation of protein stability GO:0031647 48 32 3,000 8,411E-05 8,061E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 9,013E-05 8,292E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,039E-04 9,194E-03 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 2,000 1,039E-04 8,853E-03 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! negative regulation of cell size GO:0045792 108 64 4,000 1,05E-04 8,622E-03 ! regulation of skeletal muscle tissue development GO:0048641 22 14 2,000 1,316E-04 0,01043435 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 2,000 1,316E-04 0,01008653 ! epidermis morphogenesis GO:0048730 29 14 2,000 1,316E-04 9,761E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,316E-04 9,456E-03 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 2,000 1,636E-04 0,01140071 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,636E-04 0,01106539 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,636E-04 0,01074924 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,636E-04 0,01045065 ! regulation of BMP signaling pathway GO:0030510 21 15 2,000 1,636E-04 0,0101682 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,636E-04 9,901E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 2,000 2,002E-04 0,01180949 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,002E-04 0,01151425 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 2,043E-04 0,01146132 ! negative regulation of growth GO:0045926 123 75 4,000 2,228E-04 0,012203 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,419E-04 0,01293666 ! cell-substrate junction assembly GO:0007044 39 17 2,000 2,419E-04 0,01264264 ! nucleobase metabolic process GO:0009112 31 17 2,000 2,419E-04 0,01236169 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,419E-04 0,01209296 ! regulation of glucose import GO:0046324 21 18 2,000 2,887E-04 0,01412696 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 2,887E-04 0,01383265 ! response to alkaloid GO:0043279 32 19 2,000 3,41E-04 0,01600514 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 3,41E-04 0,01568504 ! apoptotic nuclear changes GO:0030262 24 19 2,000 3,41E-04 0,01537749 ! renal system process GO:0003014 35 19 2,000 3,41E-04 0,01508177 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 2,000 3,41E-04 0,01479721 ! regulation of ossification GO:0030278 71 46 3,000 3,527E-04 0,0150206 ! regulation of neuron apoptosis GO:0043523 77 47 3,000 3,833E-04 0,01602862 ! positive regulation of locomotion GO:0040017 35 20 2,000 3,99E-04 0,01638796 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 3,99E-04 0,01610045 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 3,000 4,502E-04 0,01785261 ! cartilage development GO:0051216 70 49 3,000 4,502E-04 0,01755003 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 4,63E-04 0,01774947 ! regulation of chemotaxis GO:0050920 36 21 2,000 4,63E-04 0,0174585 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 4,63E-04 0,01717691 ! cell aging GO:0007569 32 21 2,000 4,63E-04 0,01690426 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 4,63E-04 0,01664013 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 2,000 4,63E-04 0,01638413 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 5,243E-04 0,01827122 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,243E-04 0,01799852 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 5,243E-04 0,01773384 ! peptidyl-histidine phosphorylation GO:0018106 7 5 1,000 5,243E-04 0,01747682 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 1,000 5,243E-04 0,01722715 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 5,243E-04 0,01698452 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 5,243E-04 0,01674862 ! triglyceride catabolic process GO:0019433 6 5 1,000 5,243E-04 0,01651919 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 5,243E-04 0,01629596 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 5,243E-04 0,01607868 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 5,333E-04 0,01613875 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 38 22 2,000 5,333E-04 0,01592916 ! leukocyte homeostasis GO:0001776 33 22 2,000 5,333E-04 0,01572494 ! aging GO:0007568 79 52 3,000 5,656E-04 0,0164665 ! regulation of bone remodeling GO:0046850 90 53 3,000 6,083E-04 0,01748919 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 6,1E-04 0,01732108 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 2,000 6,1E-04 0,01710985 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! regulation of tissue remodeling GO:0034103 91 54 3,000 6,533E-04 0,01810329 ! fat cell differentiation GO:0045444 37 24 2,000 6,934E-04 0,01898681 ! prostate gland development GO:0030850 9 6 1,000 7,827E-04 0,02117851 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 7,827E-04 0,02093225 ! neuron adhesion GO:0007158 9 6 1,000 7,827E-04 0,02069165 ! pigment granule organization GO:0048753 11 6 1,000 7,827E-04 0,02045652 ! ER overload response GO:0006983 7 6 1,000 7,827E-04 0,02022667 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 7,827E-04 0,02000193 ! glycerol ether catabolic process GO:0044269 8 6 1,000 7,827E-04 0,01978213 GO:0046464|acylglycerol catabolic process, ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 7,827E-04 0,0195671 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 7,827E-04 0,0193567 ! neutrophil homeostasis GO:0001780 6 6 1,000 7,827E-04 0,01915078 ! peptidyl-histidine modification GO:0018202 9 6 1,000 7,827E-04 0,01894919 ! axonal fasciculation GO:0007413 9 6 1,000 7,827E-04 0,01875181 ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 7,827E-04 0,01855849 ! negative regulation of B cell activation GO:0050869 9 6 1,000 7,827E-04 0,01836912 ! male gonad development GO:0008584 33 25 2,000 7,838E-04 0,0182093 ! regulation of chromosome organization GO:0033044 35 25 2,000 7,838E-04 0,01802721 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 7,838E-04 0,01784872 ! post-embryonic development GO:0009791 42 26 2,000 8,813E-04 0,0198726 ! negative regulation of protein modification process GO:0031400 50 26 2,000 8,813E-04 0,01967966 ! nucleoside monophosphate metabolic process GO:0009123 95 59 3,000 9,141E-04 0,02021486 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 9,862E-04 0,02160228 ! negative regulation of neuron apoptosis GO:0043524 42 27 2,000 9,862E-04 0,02139849 ! urogenital system development GO:0001655 101 61 3,000 1,036E-03 0,02227663 ! homeostasis of number of cells GO:0048872 84 61 3,000 1,036E-03 0,02207037 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,091E-03 0,02301063 ! neutral lipid catabolic process GO:0046461 9 7 1,000 1,091E-03 0,02280145 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,091E-03 0,02259603 ! pericardium development GO:0060039 8 7 1,000 1,091E-03 0,02239428 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,091E-03 0,0221961 ! glycerolipid catabolic process GO:0046503 9 7 1,000 1,091E-03 0,02200139 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,091E-03 0,02181008 ! organ growth GO:0035265 11 7 1,000 1,091E-03 0,02162206 ! behavioral fear response GO:0001662 13 7 1,000 1,091E-03 0,02143726 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 1,091E-03 0,02125558 ! B cell lineage commitment GO:0002326 17 7 1,000 1,091E-03 0,02107697 ! T cell lineage commitment GO:0002360 12 7 1,000 1,091E-03 0,02090132 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,091E-03 0,02072859 ! diuresis GO:0030146 12 7 1,000 1,091E-03 0,02055868 GO:0030147|natriuresis, ! regulation of synaptogenesis GO:0051963 10 7 1,000 1,091E-03 0,02039154 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,091E-03 0,02022709 ! cell junction assembly GO:0034329 56 28 2,000 1,099E-03 0,02021526 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,099E-03 0,02005482 ! cell cycle checkpoint GO:0000075 108 64 3,000 1,241E-03 0,02246886 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 1,241E-03 0,02229332 ! reproductive structure development GO:0048608 90 65 3,000 1,315E-03 0,02343886 ! spindle organization GO:0007051 37 30 2,000 1,347E-03 0,0238339 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,347E-03 0,02365196 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,447E-03 0,02521353 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,447E-03 0,02502396 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 1,447E-03 0,02483721 GO:0046579|positive regulation of Ras protein signal transduction, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,447E-03 0,02465323 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,447E-03 0,02447196 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,447E-03 0,02429333 ! melanin metabolic process GO:0006582 12 8 1,000 1,447E-03 0,02411729 ! macrophage activation GO:0042116 12 8 1,000 1,447E-03 0,02394379 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,447E-03 0,02377276 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,447E-03 0,02360416 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,447E-03 0,02343793 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,447E-03 0,02327403 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,447E-03 0,02311241 ! myeloid cell homeostasis GO:0002262 8 8 1,000 1,447E-03 0,02295301 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,447E-03 0,0227958 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 1,447E-03 0,02264072 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 1,484E-03 0,02305499 ! metanephros development GO:0001656 58 31 2,000 1,484E-03 0,02290026 ! response to mechanical stimulus GO:0009612 43 31 2,000 1,484E-03 0,02274759 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,484E-03 0,02259694 GO:0060326|cell chemotaxis, ! regulation of muscle development GO:0048634 48 32 2,000 1,628E-03 0,02463885 ! meiosis I GO:0007127 52 32 2,000 1,628E-03 0,02447781 ! response to metal ion GO:0010038 103 70 3,000 1,731E-03 0,02585283 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 1,731E-03 0,02568603 ! cell junction organization GO:0034330 63 33 2,000 1,782E-03 0,02626747 ! nucleus organization GO:0006997 49 33 2,000 1,782E-03 0,02610016 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,782E-03 0,02593497 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 2,000 1,782E-03 0,02577186 ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 1,824E-03 0,02622125 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 1,824E-03 0,02605838 ! regulation of developmental growth GO:0048638 13 9 1,000 1,852E-03 0,02628767 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 1,852E-03 0,0261264 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 1,852E-03 0,02596709 ! T cell selection GO:0045058 18 9 1,000 1,852E-03 0,02580972 ! mannose metabolic process GO:0006013 9 9 1,000 1,852E-03 0,02565424 ! motor axon guidance GO:0008045 14 9 1,000 1,852E-03 0,02550062 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,852E-03 0,02534883 ! renal water homeostasis GO:0003091 14 9 1,000 1,852E-03 0,02519884 ! oocyte differentiation GO:0009994 12 9 1,000 1,852E-03 0,02505061 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,852E-03 0,02490411 ! spleen development GO:0048536 15 9 1,000 1,852E-03 0,02475932 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,852E-03 0,0246162 ! natural killer cell mediated immunity GO:0002228 13 9 1,000 1,852E-03 0,02447473 GO:0042267|natural killer cell mediated cytotoxicity, ! response to nicotine GO:0035094 16 9 1,000 1,852E-03 0,02433488 ! regulation of synapse organization GO:0050807 12 9 1,000 1,852E-03 0,02419661 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 1,921E-03 0,02495659 GO:0045937|positive regulation of phosphate metabolic process, ! development of primary male sexual characteristics GO:0046546 44 34 2,000 1,944E-03 0,02511464 ! neuron migration GO:0001764 46 34 2,000 1,944E-03 0,02497434 ! regulation of blood pressure GO:0008217 107 73 3,000 2,021E-03 0,02581796 ! mitochondrion organization GO:0007005 104 73 3,000 2,021E-03 0,02567531 ! response to inorganic substance GO:0010035 115 75 3,000 2,231E-03 0,02819586 ! regulation of ligase activity GO:0051340 114 75 3,000 2,231E-03 0,02804179 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,303E-03 0,02879225 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 2,303E-03 0,02863662 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,303E-03 0,02848266 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,303E-03 0,02833034 GO:0010812|negative regulation of cell-substrate adhesion, ! B cell proliferation GO:0042100 14 10 1,000 2,303E-03 0,02817965 ! fear response GO:0042596 16 10 1,000 2,303E-03 0,02803055 ! negative regulation of ossification GO:0030279 19 10 1,000 2,303E-03 0,02788302 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,303E-03 0,02773704 ! protein sumoylation GO:0016925 12 10 1,000 2,303E-03 0,02759257 ! multicellular organismal water homeostasis GO:0050891 15 10 1,000 2,303E-03 0,02744961 ! regulation of synapse structure and activity GO:0050803 13 10 1,000 2,303E-03 0,02730811 ! gland development GO:0048732 148 77 3,000 2,456E-03 0,02897337 ! sex differentiation GO:0007548 105 77 3,000 2,456E-03 0,02882555 ! ribonucleoside metabolic process GO:0009119 48 37 2,000 2,484E-03 0,02899851 ! positive regulation of protein modification process GO:0031401 107 78 3,000 2,575E-03 0,0299086 ! striated muscle cell differentiation GO:0051146 54 38 2,000 2,682E-03 0,03100233 ! regulation of T cell proliferation GO:0042129 58 38 2,000 2,682E-03 0,03084732 ! pigmentation GO:0043473 74 38 2,000 2,682E-03 0,03069385 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,802E-03 0,03190139 ! plasma membrane organization GO:0007009 18 11 1,000 2,802E-03 0,03174424 ! T cell homeostasis GO:0043029 20 11 1,000 2,802E-03 0,03158863 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,802E-03 0,03143454 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! leukocyte mediated cytotoxicity GO:0001909 17 11 1,000 2,802E-03 0,03128195 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 2,000 2,89E-03 0,03211663 ! male sex differentiation GO:0046661 53 39 2,000 2,89E-03 0,03196222 ! response to calcium ion GO:0051592 58 40 2,000 3,108E-03 0,03420612 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 3,108E-03 0,03404324 ! regulation of cell adhesion GO:0030155 159 83 3,000 3,225E-03 0,03515746 ! regulation of T cell differentiation GO:0045580 59 41 2,000 3,336E-03 0,03619153 ! cartilage condensation GO:0001502 18 12 1,000 3,346E-03 0,03613111 ! gland morphogenesis GO:0022612 23 12 1,000 3,346E-03 0,03596227 ! response to gamma radiation GO:0010332 20 12 1,000 3,346E-03 0,035795 ! rRNA metabolic process GO:0016072 107 85 3,000 3,514E-03 0,03742019 GO:0006364|rRNA processing, ! cellular component disassembly GO:0022411 64 42 2,000 3,573E-03 0,03787571 ! cell cycle arrest GO:0007050 150 86 3,000 3,665E-03 0,03866846 ! leukocyte migration GO:0050900 60 43 2,000 3,821E-03 0,04013089 ! activation of caspase activity GO:0006919 65 43 2,000 3,821E-03 0,03994848 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 3,821E-03 0,03976772 ! cGMP metabolic process GO:0046068 16 13 1,000 3,936E-03 0,04077353 GO:0006182|cGMP biosynthetic process, ! endocrine pancreas development GO:0031018 19 13 1,000 3,936E-03 0,04059069 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 3,936E-03 0,04040949 ! cellular pigmentation GO:0033059 24 13 1,000 3,936E-03 0,04022989 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,936E-03 0,04005188 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,079E-03 0,04132954 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 4,079E-03 0,04114827 ! regulation of inflammatory response GO:0050727 60 44 2,000 4,079E-03 0,04096858 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 4,079E-03 0,04079046 ! reproductive developmental process GO:0003006 127 89 3,000 4,144E-03 0,04125984 ! positive regulation of cell cycle GO:0045787 77 45 2,000 4,347E-03 0,043098 ! positive regulation of defense response GO:0031349 59 45 2,000 4,347E-03 0,04291303 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,57E-03 0,04491416 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,57E-03 0,04472303 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,57E-03 0,04453353 ! water homeostasis GO:0030104 24 14 1,000 4,57E-03 0,04434562 ! cell killing GO:0001906 20 14 1,000 4,57E-03 0,0441593 ! response to UV GO:0009411 75 46 2,000 4,626E-03 0,04451771 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 4,846E-03 0,04643879 ! negative regulation of immune system process GO:0002683 73 47 2,000 4,915E-03 0,04690897 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 4,915E-03 0,04671514 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of caspase activity GO:0043280 72 48 2,000 5,215E-03 0,04936206 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 5,215E-03 0,04915975 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 5,215E-03 0,0489591 ! metencephalon development GO:0022037 19 15 1,000 5,247E-03 0,04906074 ! skin development GO:0043588 25 15 1,000 5,247E-03 0,04886211 ! regulation of survival gene product expression GO:0045884 20 15 1,000 5,247E-03 0,04866509 ! neuron recognition GO:0008038 22 15 1,000 5,247E-03 0,04846965 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,247E-03 0,04827577 ! embryonic hindlimb morphogenesis GO:0035116 25 15 1,000 5,247E-03 0,04808343 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 5,247E-03 0,04789263 ! regulation of vasodilation GO:0042312 24 15 1,000 5,247E-03 0,04770333 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,247E-03 0,04751552 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,247E-03 0,04732918 ! defense response to virus GO:0051607 27 15 1,000 5,247E-03 0,0471443 ! response to light stimulus GO:0009416 153 96 3,000 5,422E-03 0,04852125 ! regulation of angiogenesis GO:0045765 94 49 2,000 5,526E-03 0,04926253 ! germ cell development GO:0007281 68 49 2,000 5,526E-03 0,04907232 ! ear development GO:0043583 72 50 2,000 5,848E-03 0,05172906 ! cellular response to unfolded protein GO:0034620 19 16 1,000 5,968E-03 0,05259495 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 5,968E-03 0,0523942 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 5,968E-03 0,05219498 ! oogenesis GO:0048477 23 16 1,000 5,968E-03 0,05199728 ! G1 phase GO:0051318 27 16 1,000 5,968E-03 0,05180106 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 5,968E-03 0,05160632 ! negative regulation of translation GO:0017148 22 16 1,000 5,968E-03 0,05141304 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 6,042E-03 0,05185085 ! negative regulation of cell motion GO:0051271 104 51 2,000 6,18E-03 0,05284267 ! regulation of translation GO:0006417 151 100 3,000 6,258E-03 0,05331292 ! Ras protein signal transduction GO:0007265 162 100 3,000 6,258E-03 0,05311619 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 6,732E-03 0,05692432 ! forelimb morphogenesis GO:0035136 19 17 1,000 6,732E-03 0,05671581 ! regulation of viral genome replication GO:0045069 24 17 1,000 6,732E-03 0,05650881 ! actin filament bundle formation GO:0051017 26 17 1,000 6,732E-03 0,05630333 ! neuromuscular junction development GO:0007528 23 17 1,000 6,732E-03 0,05609933 ! body fluid secretion GO:0007589 27 17 1,000 6,732E-03 0,0558968 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 6,732E-03 0,05569574 ! positive regulation of synaptic transmission GO:0050806 24 17 1,000 6,732E-03 0,05549611 ! skeletal system morphogenesis GO:0048705 78 53 2,000 6,879E-03 0,05650605 ! kidney development GO:0001822 90 53 2,000 6,879E-03 0,05630496 ! DNA catabolic process GO:0006308 67 54 2,000 7,245E-03 0,05909218 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 7,537E-03 0,06125741 ! pancreas development GO:0031016 26 18 1,000 7,537E-03 0,06104171 ! visual learning GO:0008542 35 18 1,000 7,537E-03 0,06082753 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 1,000 7,537E-03 0,06061485 ! gut development GO:0048565 26 18 1,000 7,537E-03 0,06040364 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 7,537E-03 0,06019391 ! nucleoside metabolic process GO:0009116 69 55 2,000 7,623E-03 0,06066581 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 8,012E-03 0,06354189 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 8,384E-03 0,06626492 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 8,384E-03 0,06603799 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 8,384E-03 0,0658126 ! regeneration GO:0031099 32 19 1,000 8,384E-03 0,06558875 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 8,384E-03 0,06536641 ! smooth muscle contraction GO:0006939 36 19 1,000 8,384E-03 0,06514558 ! sex determination GO:0007530 29 19 1,000 8,384E-03 0,06492624 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 8,384E-03 0,06470836 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 8,384E-03 0,06449195 ! positive regulation of neurological system process GO:0031646 28 19 1,000 8,384E-03 0,06427697 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 8,384E-03 0,06406343 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 8,412E-03 0,06406742 ! gonad development GO:0008406 79 57 2,000 8,412E-03 0,06385598 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 8,824E-03 0,06676389 ! actin filament organization GO:0007015 95 59 2,000 9,248E-03 0,06974064 ! hindlimb morphogenesis GO:0035137 32 20 1,000 9,271E-03 0,06968526 ! response to ethanol GO:0045471 37 20 1,000 9,271E-03 0,06945827 ! multicellular organismal response to stress GO:0033555 32 20 1,000 9,271E-03 0,06923275 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 9,271E-03 0,0690087 ! collagen fibril organization GO:0030199 45 20 1,000 9,271E-03 0,06878609 ! regulation of heart contraction GO:0008016 91 60 2,000 9,684E-03 0,07161585 ! regulation of homeostatic process GO:0032844 105 60 2,000 9,684E-03 0,07138631 ! meiosis GO:0007126 96 61 2,000 0,01013099 0,07444494 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 0,01013099 0,07420785 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01019834 0,07446408 ! dendrite development GO:0016358 35 21 1,000 0,01019834 0,07422843 ! visual behavior GO:0007632 39 21 1,000 0,01019834 0,07399428 ! ovarian follicle development GO:0001541 30 21 1,000 0,01019834 0,07376159 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01019834 0,07353036 ! regulation of bone mineralization GO:0030500 29 21 1,000 0,01019834 0,07330058 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01019834 0,07307223 ! lymphocyte mediated immunity GO:0002449 88 62 2,000 0,01059011 0,07564362 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 0,01059011 0,07540943 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01059011 0,07517668 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,01106113 0,07827875 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01106113 0,07803863 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01116485 0,07852951 ! molting cycle process GO:0022404 40 22 1,000 0,01116485 0,07829009 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01116485 0,07805213 ! vasculogenesis GO:0001570 33 22 1,000 0,01116485 0,0778156 ! ureteric bud development GO:0001657 32 22 1,000 0,01116485 0,07758051 ! neural tube closure GO:0001843 33 22 1,000 0,01116485 0,07734684 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of caspase activity GO:0043281 97 65 2,000 0,01203908 0,08315277 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 0,01203908 0,08290381 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01203908 0,08265634 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01217007 0,08330703 ! myelination GO:0042552 35 23 1,000 0,01217007 0,08305983 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01217007 0,08281409 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01217007 0,0825698 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01217007 0,08232695 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01217007 0,08208552 ! regulation of biomineral formation GO:0070167 31 23 1,000 0,01217007 0,08184551 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,0125461 0,08412836 ! axon guidance GO:0007411 99 66 2,000 0,0125461 0,0838838 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01306521 0,08710143 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01306521 0,08684969 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,0132134 0,08758162 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,0132134 0,08732995 ! response to toxin GO:0009636 38 24 1,000 0,0132134 0,08707972 ! primary neural tube formation GO:0014020 35 24 1,000 0,0132134 0,08683093 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,0132134 0,08658354 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01359646 0,08884051 ! positive regulation of ligase activity GO:0051351 99 69 2,000 0,01413988 0,09212952 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01429424 0,09287216 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 1,000 0,01429424 0,09261055 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01429424 0,09235041 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 1,000 0,01429424 0,09209172 GO:0032943|mononuclear cell proliferation, ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 2,000 0,0146955 0,09441242 ! humoral immune response GO:0006959 86 70 2,000 0,0146955 0,09414944 ! eye development GO:0001654 111 70 2,000 0,0146955 0,09388791 ! muscle cell differentiation GO:0042692 104 71 2,000 0,01526336 0,09724575 ! leukocyte mediated immunity GO:0002443 99 71 2,000 0,01526336 0,09697712 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01541198 0,09765167 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,01584348 0,10010988 ! regulation of synaptic transmission GO:0050804 109 72 2,000 0,01584348 0,0998356 ! negative regulation of transport GO:0051051 116 73 2,000 0,01643589 0,10328564 ! tube morphogenesis GO:0035239 118 73 2,000 0,01643589 0,1030042 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01656604 0,10353778 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01656604 0,10325719 GO:0043433|negative regulation of transcription factor activity, ! protein import into nucleus GO:0006606 118 74 2,000 0,01704061 0,10592814 ! response to nutrient GO:0007584 104 75 2,000 0,01765767 0,10946807 ! nuclear import GO:0051170 121 75 2,000 0,01765767 0,1091738 ! complement activation, classical pathway GO:0006958 36 28 1,000 0,01775584 0,10948644 ! triglyceride metabolic process GO:0006641 34 28 1,000 0,01775584 0,10919369 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01775584 0,10890251 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01775584 0,10861288 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01775584 0,10832478 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01775584 0,1080382 GO:0008366|axon ensheathment, ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,01775584 0,10775314 ! neural tube formation GO:0001841 41 28 1,000 0,01775584 0,10746958 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01775584 0,10718751 ! regulation of transmission of nerve impulse GO:0051969 116 77 2,000 0,01892887 0,11396965 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,0189808 0,11398393 ! ovulation cycle process GO:0022602 41 29 1,000 0,0189808 0,1136871 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,0189808 0,11339181 ! tissue homeostasis GO:0001894 42 29 1,000 0,0189808 0,11309805 GO:0048871|multicellular organismal homeostasis, ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,02024035 0,12029149 ! ovulation cycle GO:0042698 43 30 1,000 0,02024035 0,11998146 ! hindbrain development GO:0030902 45 30 1,000 0,02024035 0,11967302 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02024035 0,11936617 ! response to heat GO:0009408 41 30 1,000 0,02024035 0,11906088 ! protein localization in nucleus GO:0034504 133 80 2,000 0,02092855 0,12279509 ! forebrain development GO:0030900 131 80 2,000 0,02092855 0,12248264 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02153392 0,12570565 ! mammary gland development GO:0030879 57 31 1,000 0,02153392 0,1253874 ! odontogenesis GO:0042476 50 31 1,000 0,02153392 0,12507077 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02161992 0,12525395 ! response to protein stimulus GO:0051789 111 81 2,000 0,02161992 0,12493924 ! regulation of neurological system process GO:0031644 122 81 2,000 0,02161992 0,12462611 ! ossification GO:0001503 134 82 2,000 0,0223237 0,12836127 GO:0060348|bone development, ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02286096 0,13112274 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,02286096 0,13079656 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,02286096 0,13047201 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 1,000 0,02286096 0,13014906 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,02286096 0,1298277 ! regulation of defense response GO:0031347 117 84 2,000 0,02376849 0,13464907 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02376849 0,13431824 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02422092 0,13653951 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02422092 0,13620568 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02422092 0,13587347 ! ear morphogenesis GO:0042471 42 33 1,000 0,02422092 0,13554287 ! female gonad development GO:0008585 49 33 1,000 0,02422092 0,13521389 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02422092 0,13488649 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02422092 0,13456068 ! cytokinesis GO:0000910 52 33 1,000 0,02422092 0,13423644 ! regulation of protein localization GO:0032880 132 85 2,000 0,0245095 0,13550924 ! regulation of membrane potential GO:0042391 128 85 2,000 0,0245095 0,13518428 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02561325 0,14093416 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02561325 0,1405978 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,02561325 0,14026304 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02561325 0,13992988 ! female gamete generation GO:0007292 43 34 1,000 0,02561325 0,13959829 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,02561325 0,13926827 ! protein processing GO:0016485 114 88 2,000 0,02680691 0,14541485 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02703741 0,14632012 ! cyclic nucleotide metabolic process GO:0009187 58 35 1,000 0,02703741 0,14597664 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02703741 0,14563478 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,02703741 0,14529451 ! glycogen metabolic process GO:0005977 48 35 1,000 0,02703741 0,14495583 ! pigment metabolic process GO:0042440 61 35 1,000 0,02703741 0,14461872 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,02759748 0,14727194 ! regulation of T cell activation GO:0050863 128 89 2,000 0,02759748 0,14693103 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,02849287 0,15134783 ! negative regulation of binding GO:0051100 58 36 1,000 0,02849287 0,1509991 ! organic ether metabolic process GO:0018904 46 36 1,000 0,02849287 0,15065198 ! neural tube development GO:0021915 50 36 1,000 0,02849287 0,15030645 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02849287 0,1499625 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,02849287 0,14962012 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,02997911 0,15706594 GO:0006956|complement activation, ! learning GO:0007612 67 37 1,000 0,02997911 0,15670897 ! DNA recombination GO:0006310 146 92 2,000 0,0300433 0,1566884 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,03149559 0,1638911 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,03149559 0,16352114 ! phagocytosis GO:0006909 60 38 1,000 0,03149559 0,16315285 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03149559 0,16278621 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of binding GO:0051098 151 95 2,000 0,03259989 0,16811604 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,03304181 0,17001381 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03304181 0,16963432 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,03304181 0,16925651 ! developmental growth GO:0048589 62 39 1,000 0,03304181 0,16888039 ! cell growth GO:0016049 61 39 1,000 0,03304181 0,16850593 ! synapse organization GO:0050808 55 39 1,000 0,03304181 0,16813313 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,03347661 0,16996953 ! protein maturation GO:0051604 129 96 2,000 0,03347661 0,16959515 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03461726 0,17498836 ! T cell differentiation GO:0030217 65 40 1,000 0,03461726 0,17460462 ! B cell differentiation GO:0030183 62 40 1,000 0,03461726 0,17422255 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03461726 0,17384215 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03461726 0,17346341 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03608097 0,18040486 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03608097 0,18001353 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03608097 0,17962389 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03608097 0,17923593 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03608097 0,17884965 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03608097 0,17846502 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03608097 0,17808205 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03608097 0,17770072 ! sleep GO:0030431 11 5 0,000 0,03608097 0,17732102 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03608097 0,17694293 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03608097 0,17656646 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03608097 0,17619158 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03608097 0,1758183 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03608097 0,17544659 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03608097 0,17507645 ! tongue development GO:0043586 6 5 0,000 0,03608097 0,17470786 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03608097 0,17434083 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03608097 0,17397534 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03608097 0,17361137 ! cobalt ion transport GO:0006824 9 5 0,000 0,03608097 0,17324893 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03608097 0,17288799 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03608097 0,17252856 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03608097 0,17217061 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03608097 0,17181415 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03608097 0,17145916 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03608097 0,17110564 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03608097 0,17075357 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03608097 0,17040295 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03608097 0,17005376 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03608097 0,169706 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03608097 0,16935966 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03608097 0,16901474 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03608097 0,16867121 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03608097 0,16832908 ! malate metabolic process GO:0006108 7 5 0,000 0,03608097 0,16798833 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03608097 0,16764896 ! behavioral response to pain GO:0048266 7 5 0,000 0,03608097 0,16731096 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03608097 0,16697432 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03608097 0,16663903 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03608097 0,16630508 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03608097 0,16597247 ! mating behavior GO:0007617 6 5 0,000 0,03608097 0,16564119 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03608097 0,16531123 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03608097 0,16498258 ! rhythmic behavior GO:0007622 12 5 0,000 0,03608097 0,16465523 ! copulation GO:0007620 7 5 0,000 0,03608097 0,16432918 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03608097 0,16400442 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03608097 0,16368094 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03608097 0,16335873 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03608097 0,16303779 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03608097 0,16271811 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03608097 0,16239968 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03608097 0,16208249 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03608097 0,16176654 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03608097 0,16145182 ! response to protozoan GO:0001562 9 5 0,000 0,03608097 0,16113832 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03608097 0,16082604 ! lymph vessel development GO:0001945 7 5 0,000 0,03608097 0,16051496 ! endochondral ossification GO:0001958 12 5 0,000 0,03608097 0,16020509 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03608097 0,15989641 ! parathyroid gland development GO:0060017 8 5 0,000 0,03608097 0,15958891 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03608097 0,1592826 ! anagen GO:0042640 6 5 0,000 0,03608097 0,15897746 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03608097 0,15867349 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03608097 0,15837068 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03608097 0,15806902 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03608097 0,15776851 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03608097 0,15746914 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03608097 0,1571709 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03608097 0,15687379 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03608097 0,1565778 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03608097 0,15628293 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03608097 0,15598916 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03608097 0,1556965 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03608097 0,15540494 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03608097 0,15511446 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03608097 0,15482507 ! ovulation GO:0030728 6 5 0,000 0,03608097 0,15453675 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03608097 0,15424951 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03608097 0,15396333 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,03608097 0,15367821 ! response to pH GO:0009268 9 5 0,000 0,03608097 0,15339415 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03608097 0,15311114 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03608097 0,15282916 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03608097 0,15254823 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03608097 0,15226832 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03608097 0,15198944 ! polyol catabolic process GO:0046174 7 5 0,000 0,03608097 0,15171158 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03608097 0,15143474 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03608097 0,1511589 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03608097 0,15088406 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03608097 0,15061023 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03608097 0,15033738 ! urea metabolic process GO:0019627 6 5 0,000 0,03608097 0,15006553 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03608097 0,14979465 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03608097 0,14952475 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03608097 0,14925582 ! neutrophil activation GO:0042119 5 5 0,000 0,03608097 0,14898786 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03608097 0,14872085 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03608097 0,1484548 ! response to food GO:0032094 5 5 0,000 0,03608097 0,14818971 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03608097 0,14792555 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03608097 0,14766234 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03608097 0,14740006 ! forebrain neuron development GO:0021884 7 5 0,000 0,03608097 0,14713872 ! melanosome organization GO:0032438 7 5 0,000 0,03608097 0,14687829 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03608097 0,14661879 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03608097 0,1463602 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03608097 0,14610253 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03608097 0,14584576 GO:0009251|glucan catabolic process, ! nucleoside transport GO:0015858 6 5 0,000 0,03608097 0,14558989 ! nucleoside salvage GO:0043174 7 5 0,000 0,03608097 0,14533491 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03608097 0,14508083 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03608097 0,14482764 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03608097 0,14457532 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03608097 0,14432389 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03608097 0,14407333 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03608097 0,14382363 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03608097 0,1435748 ! depyrimidination GO:0045008 8 5 0,000 0,03608097 0,14332683 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03608097 0,14307972 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03608097 0,14283345 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03608097 0,14258803 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03608097 0,14234346 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03608097 0,14209972 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03608097 0,14185681 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03608097 0,14161474 ! monocyte differentiation GO:0030224 8 5 0,000 0,03608097 0,14137348 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03608097 0,14113305 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03608097 0,14089344 ! centrosome duplication GO:0051298 5 5 0,000 0,03608097 0,14065464 ! response to UV-C GO:0010225 6 5 0,000 0,03608097 0,14041664 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03608097 0,14017945 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03608097 0,13994306 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03608097 0,13970747 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03608097 0,13947266 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03608097 0,13923865 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03608097 0,13900542 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03608097 0,13877297 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03608097 0,13854129 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03608097 0,13831039 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03608097 0,13808026 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03608097 0,13785089 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03608097 0,13762228 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03608097 0,13739443 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03608097 0,13716733 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03608097 0,13694098 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03608097 0,13671538 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03608097 0,13649052 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03608097 0,1362664 ! neural tube patterning GO:0021532 6 5 0,000 0,03608097 0,13604301 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03608097 0,13582035 ! histone demethylation GO:0016577 9 5 0,000 0,03608097 0,13559842 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03608097 0,13537722 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03608097 0,13515674 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03608097 0,13493697 ! enteric nervous system development GO:0048484 8 5 0,000 0,03608097 0,13471791 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03608097 0,13449957 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03608097 0,13428193 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03608097 0,134065 ! transcription termination GO:0006353 8 5 0,000 0,03608097 0,13384877 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03608097 0,13363323 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03608097 0,13341839 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03608097 0,13320423 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03608097 0,13299076 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03608097 0,13277798 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03608097 0,13256587 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03608097 0,13235444 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03608097 0,13214369 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03608097 0,1319336 ! apical protein localization GO:0045176 6 5 0,000 0,03608097 0,13172418 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03608097 0,13151543 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03608097 0,13130733 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03608097 0,1310999 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03608097 0,13089312 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03608097 0,13068699 ! glial cell migration GO:0008347 10 5 0,000 0,03608097 0,1304815 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03608097 0,13027667 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03608097 0,13007247 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03608097 0,12986891 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03608097 0,12966599 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03608097 0,12946371 ! neural plate development GO:0001840 6 5 0,000 0,03608097 0,12926205 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03608097 0,12906102 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03608097 0,12886061 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03608097 0,12866083 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03608097 0,12846167 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03608097 0,12826312 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03608097 0,12806518 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03608097 0,12786785 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03608097 0,12767113 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03608097 0,12747502 ! spindle assembly GO:0051225 5 5 0,000 0,03608097 0,1272795 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03608097 0,12708459 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03608097 0,12689027 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03608097 0,12669654 ! organ regeneration GO:0031100 7 5 0,000 0,03608097 0,12650341 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03608097 0,12631086 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03608097 0,1261189 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03608097 0,12592752 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03608097 0,12573672 GO:0055081|anion homeostasis, ! calcium ion transport GO:0006816 167 99 2,000 0,03617994 0,12589086 ! extracellular structure organization GO:0043062 156 99 2,000 0,03617994 0,12570069 ! protein import GO:0017038 156 99 2,000 0,03617994 0,1255111 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03622143 0,12546581 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,03622143 0,12527714 ! glucose transport GO:0015758 52 41 1,000 0,03622143 0,12508904 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,03622143 0,1249015 ! divalent metal ion transport GO:0070838 171 100 2,000 0,03710534 0,12775792 ! regulation of body fluid levels GO:0050878 154 100 2,000 0,03710534 0,12756695 ! protein localization in organelle GO:0033365 161 100 2,000 0,03710534 0,12737655 ! mitochondrial transport GO:0006839 60 42 1,000 0,03785383 0,12975233 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,03785383 0,12955925 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,03785383 0,12936674 ! hexose transport GO:0008645 54 42 1,000 0,03785383 0,1291748 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,03785383 0,12898343 ! excretion GO:0007588 63 42 1,000 0,03785383 0,12879262 ! vesicle organization GO:0016050 79 43 1,000 0,03951396 0,13424241 ! response to insulin stimulus GO:0032868 63 43 1,000 0,03951396 0,13404441 ! regulation of action potential GO:0001508 71 44 1,000 0,04120134 0,13956271 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04120134 0,13935747 ! regulation of translational initiation GO:0006446 64 45 1,000 0,04291548 0,14494216 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,04291548 0,14472963 ! cell recognition GO:0008037 58 45 1,000 0,04291548 0,14451773 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,04291548 0,14430644 ! tRNA transcription GO:0009304 11 6 0,000 0,04314063 0,14485175 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04314063 0,14464059 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04314063 0,14443006 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04314063 0,14422013 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04314063 0,14401081 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04314063 0,1438021 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04314063 0,14359399 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04314063 0,14338649 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04314063 0,14317958 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04314063 0,14297327 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04314063 0,14276755 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04314063 0,14256243 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04314063 0,14235789 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04314063 0,14215394 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04314063 0,14195057 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04314063 0,14174778 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04314063 0,14154557 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04314063 0,14134394 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04314063 0,14114288 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04314063 0,1409424 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04314063 0,14074248 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04314063 0,14054313 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04314063 0,14034434 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04314063 0,14014611 ! signal peptide processing GO:0006465 8 6 0,000 0,04314063 0,13994845 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04314063 0,13975134 ! mRNA stabilization GO:0048255 15 6 0,000 0,04314063 0,13955478 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04314063 0,13935878 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04314063 0,13916332 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04314063 0,13896841 ! opsonization GO:0008228 8 6 0,000 0,04314063 0,13877405 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04314063 0,13858023 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04314063 0,13838696 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04314063 0,13819422 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04314063 0,13800201 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04314063 0,13781034 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04314063 0,13761921 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04314063 0,1374286 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04314063 0,13723852 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04314063 0,13704896 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04314063 0,13685993 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04314063 0,13667142 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04314063 0,13648342 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04314063 0,13629595 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04314063 0,13610898 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04314063 0,13592253 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04314063 0,13573659 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04314063 0,13555116 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04314063 0,13536623 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04314063 0,13518181 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04314063 0,13499789 ! thymic T cell selection GO:0045061 12 6 0,000 0,04314063 0,13481447 ! protein lipoylation GO:0009249 10 6 0,000 0,04314063 0,13463154 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04314063 0,13444912 ! drug transport GO:0015893 6 6 0,000 0,04314063 0,13426718 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04314063 0,13408574 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04314063 0,13390479 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04314063 0,13372432 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04314063 0,13354434 ! histidine metabolic process GO:0006547 6 6 0,000 0,04314063 0,13336485 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04314063 0,13318584 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04314063 0,1330073 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04314063 0,13282925 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04314063 0,13265167 ! adenohypophysis development GO:0021984 10 6 0,000 0,04314063 0,13247456 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04314063 0,13229793 ! hyperosmotic response GO:0006972 8 6 0,000 0,04314063 0,13212177 ! microtubule nucleation GO:0007020 10 6 0,000 0,04314063 0,13194607 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04314063 0,13177085 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04314063 0,13159608 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04314063 0,13142179 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04314063 0,13124795 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04314063 0,13107457 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04314063 0,13090165 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04314063 0,13072918 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04314063 0,13055717 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04314063 0,13038561 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04314063 0,1302145 ! purine salvage GO:0043101 8 6 0,000 0,04314063 0,13004384 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04314063 0,12987362 ! neuron apoptosis GO:0051402 8 6 0,000 0,04314063 0,12970385 ! organic alcohol transport GO:0015850 9 6 0,000 0,04314063 0,12953453 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04314063 0,12936564 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04314063 0,1291972 ! male sex determination GO:0030238 9 6 0,000 0,04314063 0,12902919 ! carnitine transport GO:0015879 8 6 0,000 0,04314063 0,12886162 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04314063 0,12869449 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04314063 0,12852778 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04314063 0,12836151 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04314063 0,12819567 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04314063 0,12803026 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04314063 0,12786527 ! parturition GO:0007567 12 6 0,000 0,04314063 0,12770071 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04314063 0,12753657 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04314063 0,12737285 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04314063 0,12720955 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04314063 0,12704667 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04314063 0,1268842 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04314063 0,12672216 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04314063 0,12656052 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04314063 0,1263993 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04314063 0,12623848 ! macrophage differentiation GO:0030225 10 6 0,000 0,04314063 0,12607808 ! astrocyte development GO:0014002 14 6 0,000 0,04314063 0,12591808 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04314063 0,12575849 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04314063 0,1255993 ! interaction with symbiont GO:0051702 8 6 0,000 0,04314063 0,12544052 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04314063 0,12528213 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04314063 0,12512415 ! eating behavior GO:0042755 6 6 0,000 0,04314063 0,12496656 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04314063 0,12480937 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04314063 0,12465257 ! response to copper ion GO:0046688 9 6 0,000 0,04314063 0,12449617 ! DNA topological change GO:0006265 8 6 0,000 0,04314063 0,12434016 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04314063 0,12418454 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04314063 0,12402931 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04314063 0,12387447 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04314063 0,12372001 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04314063 0,12356594 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04314063 0,12341225 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04314063 0,12325894 ! gas homeostasis GO:0033483 11 6 0,000 0,04314063 0,12310601 ! hair follicle maturation GO:0048820 7 6 0,000 0,04314063 0,12295347 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04314063 0,1228013 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04314063 0,1226495 ! Schwann cell development GO:0014044 14 6 0,000 0,04314063 0,12249808 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04314063 0,12234704 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04314063 0,12219636 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04314063 0,12204606 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04314063 0,12189613 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04314063 0,12174656 ! histone ubiquitination GO:0016574 7 6 0,000 0,04314063 0,12159736 ! regulation of meiosis GO:0040020 10 6 0,000 0,04314063 0,12144853 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04314063 0,12130006 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04314063 0,12115195 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04314063 0,1210042 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04314063 0,12085682 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04314063 0,12070979 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04314063 0,12056312 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04314063 0,12041681 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04314063 0,12027085 ! receptor internalization GO:0031623 9 6 0,000 0,04314063 0,12012524 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04314063 0,11997999 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04314063 0,11983508 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04314063 0,11969053 ! protein deubiquitination GO:0016579 8 6 0,000 0,04314063 0,11954632 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04314063 0,11940246 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04314063 0,11925895 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04314063 0,11911578 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04314063 0,11897296 ! midbrain development GO:0030901 6 6 0,000 0,04314063 0,11883048 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04314063 0,11868833 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04314063 0,11854653 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04314063 0,11840507 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04314063 0,11826394 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04314063 0,11812315 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04314063 0,1179827 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04314063 0,11784257 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04314063 0,11770279 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04314063 0,11756333 ! adult feeding behavior GO:0008343 6 6 0,000 0,04314063 0,1174242 ! blastocyst growth GO:0001832 15 6 0,000 0,04314063 0,1172854 ! pigment granule transport GO:0051904 12 6 0,000 0,04314063 0,11714693 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04314063 0,11700878 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04314063 0,11687096 ! catecholamine transport GO:0051937 7 6 0,000 0,04314063 0,11673347 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04314063 0,1165963 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04314063 0,11645945 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04314063 0,11632292 ! protein prenylation GO:0018342 10 6 0,000 0,04314063 0,11618671 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04314063 0,11605082 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04314063 0,11591524 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04314063 0,11577999 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04314063 0,11564504 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04314063 0,11551042 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,04642217 0,1241523 ! endocrine system development GO:0035270 83 47 1,000 0,04642217 0,12400811 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04821377 0,12864464 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,04821377 0,12849557 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,04821377 0,12834685 GO:0019724|B cell mediated immunity, ! nuclear export GO:0051168 69 48 1,000 0,04821377 0,12819847 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,05003028 0,13287486 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,05003028 0,13272161 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05014898 0,13288325 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05014898 0,13273034 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05014898 0,13257777 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05014898 0,13242556 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05014898 0,1322737 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05014898 0,13212218 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05014898 0,13197101 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05014898 0,13182019 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05014898 0,13166971 ! reproductive behavior GO:0019098 12 7 0,000 0,05014898 0,13151957 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05014898 0,13136978 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05014898 0,13122032 ! oligopeptide transport GO:0006857 11 7 0,000 0,05014898 0,13107121 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05014898 0,13092243 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05014898 0,13077399 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05014898 0,13062589 ! RNA methylation GO:0001510 11 7 0,000 0,05014898 0,13047813 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05014898 0,13033069 ! fibril organization GO:0043206 13 7 0,000 0,05014898 0,13018359 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,05014898 0,13003682 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05014898 0,12989039 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05014898 0,12974428 ! lipoprotein transport GO:0042953 9 7 0,000 0,05014898 0,1295985 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05014898 0,12945304 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05014898 0,12930792 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05014898 0,12916312 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05014898 0,12901864 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05014898 0,12887448 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05014898 0,12873065 ! chemosensory behavior GO:0007635 9 7 0,000 0,05014898 0,12858714 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05014898 0,12844395 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05014898 0,12830107 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05014898 0,12815851 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05014898 0,12801627 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05014898 0,12787435 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05014898 0,12773274 ! reflex GO:0060004 12 7 0,000 0,05014898 0,12759144 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05014898 0,12745046 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05014898 0,12730978 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05014898 0,12716942 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05014898 0,12702936 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05014898 0,12688962 ! spinal cord patterning GO:0021511 7 7 0,000 0,05014898 0,12675018 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05014898 0,12661105 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05014898 0,12647222 ! adrenal gland development GO:0030325 17 7 0,000 0,05014898 0,12633369 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05014898 0,12619547 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05014898 0,12605756 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05014898 0,12591994 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05014898 0,12578262 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05014898 0,1256456 ! endosome organization GO:0007032 10 7 0,000 0,05014898 0,12550888 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05014898 0,12537246 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05014898 0,12523633 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05014898 0,1251005 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05014898 0,12496497 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05014898 0,12482972 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05014898 0,12469477 ! galactose metabolic process GO:0006012 10 7 0,000 0,05014898 0,12456011 ! vesicle fusion GO:0006906 15 7 0,000 0,05014898 0,12442574 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05014898 0,12429166 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05014898 0,12415787 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05014898 0,12402437 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05014898 0,12389115 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05014898 0,12375822 ! retinol metabolic process GO:0042572 9 7 0,000 0,05014898 0,12362558 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05014898 0,12349322 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05014898 0,12336114 ! rRNA modification GO:0000154 12 7 0,000 0,05014898 0,12322934 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05014898 0,12309783 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05014898 0,12296659 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,05014898 0,12283564 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05014898 0,12270496 ! intermediate filament organization GO:0045109 11 7 0,000 0,05014898 0,12257456 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05014898 0,12244444 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05014898 0,12231459 ! fibrinolysis GO:0042730 9 7 0,000 0,05014898 0,12218502 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05014898 0,12205573 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05014898 0,1219267 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05014898 0,12179795 ! response to tropane GO:0014073 13 7 0,000 0,05014898 0,12166948 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05014898 0,12154127 ! melanosome localization GO:0032400 10 7 0,000 0,05014898 0,12141333 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05014898 0,12128566 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05014898 0,12115826 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05014898 0,12103113 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05014898 0,12090426 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05014898 0,12077766 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05014898 0,12065132 ! mast cell activation GO:0045576 9 7 0,000 0,05014898 0,12052525 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05014898 0,12039944 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05014898 0,12027389 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05014898 0,12014861 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05014898 0,12002358 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05014898 0,11989882 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05014898 0,11977431 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05014898 0,11965007 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05014898 0,11952608 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05014898 0,11940234 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05014898 0,11927887 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05014898 0,11915564 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05014898 0,11903268 ! response to tumor cell GO:0002347 12 7 0,000 0,05014898 0,11890996 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05014898 0,1187875 ! neuroblast proliferation GO:0007405 13 7 0,000 0,05014898 0,11866529 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05014898 0,11854333 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05014898 0,11842163 ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05014898 0,11830017 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05014898 0,11817896 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05014898 0,118058 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05014898 0,11793728 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05014898 0,11781682 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05014898 0,11769659 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05014898 0,11757662 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05014898 0,11745689 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05014898 0,1173374 ! lymph node development GO:0048535 9 7 0,000 0,05014898 0,11721815 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05014898 0,11709915 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05014898 0,11698039 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05014898 0,11686187 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05014898 0,11674359 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05014898 0,11662554 ! ATP catabolic process GO:0006200 10 7 0,000 0,05014898 0,11650774 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05014898 0,11639017 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05014898 0,11627285 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05014898 0,11615575 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05014898 0,1160389 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05014898 0,11592227 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05014898 0,11580589 ! muscle adaptation GO:0043500 12 7 0,000 0,05014898 0,11568973 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05014898 0,11557381 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05014898 0,11545812 ! retina homeostasis GO:0001895 9 7 0,000 0,05014898 0,11534266 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05014898 0,11522744 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05014898 0,11511244 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05014898 0,11499767 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05014898 0,11488313 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05014898 0,11476882 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05014898 0,11465473 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05014898 0,11454088 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05187122 0,11835695 ! positive regulation of growth GO:0045927 67 50 1,000 0,05187122 0,11823965 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,05187122 0,11812258 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05373615 0,12224842 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,05373615 0,12212762 ! positive regulation of cell migration GO:0030335 92 51 1,000 0,05373615 0,12200706 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,05373615 0,12188674 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05562464 0,12604598 ! establishment of organelle localization GO:0051656 85 52 1,000 0,05562464 0,12592192 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0571064 0,12914919 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0571064 0,12902233 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0571064 0,12889571 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0571064 0,12876934 ! associative learning GO:0008306 15 8 0,000 0,0571064 0,12864322 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0571064 0,12851735 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0571064 0,12839172 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,0571064 0,12826634 ! phosphate transport GO:0006817 10 8 0,000 0,0571064 0,1281412 ! N-glycan processing GO:0006491 12 8 0,000 0,0571064 0,12801631 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0571064 0,12789166 ! UTP metabolic process GO:0046051 8 8 0,000 0,0571064 0,12776725 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0571064 0,12764308 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0571064 0,12751916 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0571064 0,12739547 ! succinate metabolic process GO:0006105 14 8 0,000 0,0571064 0,12727203 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0571064 0,12714882 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0571064 0,12702585 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0571064 0,12690312 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0571064 0,12678063 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0571064 0,12665837 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0571064 0,12653635 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0571064 0,12641456 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0571064 0,12629301 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0571064 0,12617169 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0571064 0,12605061 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0571064 0,12592975 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0571064 0,12580913 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0571064 0,12568874 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0571064 0,12556858 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,0571064 0,12544864 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0571064 0,12532894 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0571064 0,12520947 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0571064 0,12509022 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0571064 0,1249712 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0571064 0,12485241 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0571064 0,12473384 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0571064 0,12461549 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0571064 0,12449738 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,0571064 0,12437948 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0571064 0,12426181 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0571064 0,12414436 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,0571064 0,12402713 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0571064 0,12391012 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0571064 0,12379334 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0571064 0,12367677 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0571064 0,12356042 ! ruffle organization GO:0031529 11 8 0,000 0,0571064 0,1234443 ! osteoblast development GO:0002076 13 8 0,000 0,0571064 0,12332839 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0571064 0,12321269 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0571064 0,12309722 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0571064 0,12298196 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0571064 0,12286691 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0571064 0,12275209 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0571064 0,12263747 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0571064 0,12252307 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0571064 0,12240888 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0571064 0,12229491 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0571064 0,12218115 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0571064 0,12206759 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0571064 0,12195425 ! segment specification GO:0007379 10 8 0,000 0,0571064 0,12184112 ! cellular extravasation GO:0045123 11 8 0,000 0,0571064 0,1217282 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0571064 0,12161549 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0571064 0,12150299 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0571064 0,12139069 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0571064 0,12127861 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0571064 0,12116673 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0571064 0,12105505 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0571064 0,12094358 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0571064 0,12083232 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0571064 0,12072126 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0571064 0,1206104 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0571064 0,12049975 ! icosanoid secretion GO:0032309 12 8 0,000 0,0571064 0,1203893 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0571064 0,12027906 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0571064 0,12016901 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0571064 0,12005917 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0571064 0,11994953 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0571064 0,11984008 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0571064 0,11973084 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0571064 0,1196218 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0571064 0,11951295 ! sterol catabolic process GO:0016127 9 8 0,000 0,0571064 0,1194043 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0571064 0,11929585 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0571064 0,1191876 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0571064 0,11907954 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0571064 0,11897168 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0571064 0,11886401 ! prophase GO:0051324 11 8 0,000 0,0571064 0,11875654 ! S phase GO:0051320 8 8 0,000 0,0571064 0,11864926 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0571064 0,11854218 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0571064 0,11843528 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0571064 0,11832859 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0571064 0,11822208 ! hormone catabolic process GO:0042447 13 8 0,000 0,0571064 0,11811577 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0571064 0,11800964 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0571064 0,11790371 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0571064 0,11779796 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0571064 0,11769241 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0571064 0,11758705 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0571064 0,11748187 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0571064 0,11737688 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0571064 0,11727208 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0571064 0,11716747 ! regulation of embryonic development GO:0045995 16 8 0,000 0,0571064 0,11706304 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0571064 0,1169588 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0571064 0,11685474 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0571064 0,11675087 ! regulation of mitosis GO:0007088 84 54 1,000 0,0594705 0,12147616 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0594705 0,12136837 ! detection of external stimulus GO:0009581 66 54 1,000 0,0594705 0,12126078 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0594705 0,12115337 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,06340536 0,12905516 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,06340536 0,12894105 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,06340536 0,12882715 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06401326 0,12994748 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06401326 0,12983289 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06401326 0,1297185 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06401326 0,12960431 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06401326 0,12949032 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06401326 0,12937654 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06401326 0,12926295 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06401326 0,12914956 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06401326 0,12903637 ! GTP metabolic process GO:0046039 9 9 0,000 0,06401326 0,12892338 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06401326 0,12881058 ! social behavior GO:0035176 14 9 0,000 0,06401326 0,12869799 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06401326 0,12858559 ! artery development GO:0060840 19 9 0,000 0,06401326 0,12847338 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06401326 0,12836137 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06401326 0,12824956 ! response to pain GO:0048265 16 9 0,000 0,06401326 0,12813794 ! protein complex disassembly GO:0043241 17 9 0,000 0,06401326 0,12802652 GO:0043624|cellular protein complex disassembly, ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06401326 0,12791529 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06401326 0,12780425 ! lung alveolus development GO:0048286 17 9 0,000 0,06401326 0,12769341 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06401326 0,12758275 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06401326 0,12747229 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06401326 0,12736202 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06401326 0,12725194 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06401326 0,12714205 ! protein targeting to ER GO:0045047 19 9 0,000 0,06401326 0,12703235 ! endoderm development GO:0007492 12 9 0,000 0,06401326 0,12692284 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06401326 0,12681352 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06401326 0,12670439 ! arginine catabolic process GO:0006527 10 9 0,000 0,06401326 0,12659544 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06401326 0,12648668 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06401326 0,12637811 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06401326 0,12626972 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06401326 0,12616152 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06401326 0,12605351 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06401326 0,12594568 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06401326 0,12583803 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06401326 0,12573057 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06401326 0,12562329 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06401326 0,1255162 ! receptor clustering GO:0043113 15 9 0,000 0,06401326 0,12540928 ! epithelial cell development GO:0002064 10 9 0,000 0,06401326 0,12530255 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06401326 0,125196 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06401326 0,12508963 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06401326 0,12498344 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06401326 0,12487744 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06401326 0,12477161 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06401326 0,12466596 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06401326 0,12456049 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06401326 0,1244552 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06401326 0,12435008 ! DNA ligation GO:0006266 14 9 0,000 0,06401326 0,12424515 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06401326 0,12414039 ! response to amine stimulus GO:0014075 13 9 0,000 0,06401326 0,1240358 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06401326 0,12393139 ! erythrocyte development GO:0048821 11 9 0,000 0,06401326 0,12382716 ! postreplication repair GO:0006301 11 9 0,000 0,06401326 0,12372311 ! mRNA cleavage GO:0006379 13 9 0,000 0,06401326 0,12361922 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06401326 0,12351552 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06401326 0,12341198 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06401326 0,12330862 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06401326 0,12320544 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06401326 0,12310242 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06401326 0,12299958 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06401326 0,12289691 ! acid secretion GO:0046717 14 9 0,000 0,06401326 0,12279441 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06401326 0,12269208 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06401326 0,12258992 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06401326 0,12248793 ! purine base metabolic process GO:0006144 18 9 0,000 0,06401326 0,12238612 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06401326 0,12228447 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06401326 0,12218298 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06401326 0,12208167 ! detection of calcium ion GO:0005513 13 9 0,000 0,06401326 0,12198053 ! blastocyst formation GO:0001825 12 9 0,000 0,06401326 0,12187955 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06401326 0,12177874 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06401326 0,1216781 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06401326 0,12157762 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06401326 0,12147731 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06401326 0,12137716 ! prepulse inhibition GO:0060134 14 9 0,000 0,06401326 0,12127718 ! embryonic placenta development GO:0001892 12 9 0,000 0,06401326 0,12117736 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06401326 0,12107771 ! insulin secretion GO:0030073 17 9 0,000 0,06401326 0,12097822 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06401326 0,1208789 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06401326 0,12077973 ! nucleus localization GO:0051647 15 9 0,000 0,06401326 0,12068074 ! localization within membrane GO:0051668 15 9 0,000 0,06401326 0,1205819 ! carbohydrate transport GO:0008643 74 57 1,000 0,06540511 0,1231029 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,06540511 0,12300225 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,06540511 0,12290175 ! camera-type eye development GO:0043010 88 57 1,000 0,06540511 0,12280143 ! secondary metabolic process GO:0019748 84 57 1,000 0,06540511 0,12270126 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,06742585 0,12638911 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,06946717 0,13010951 ! lung development GO:0030324 94 59 1,000 0,06946717 0,13000365 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,06946717 0,12989795 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07086991 0,13241332 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07086991 0,13230584 ! neuron fate specification GO:0048665 11 10 0,000 0,07086991 0,13219854 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07086991 0,13209141 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07086991 0,13198445 ! thyroid gland development GO:0030878 19 10 0,000 0,07086991 0,13187767 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07086991 0,13177106 ! synapsis GO:0007129 13 10 0,000 0,07086991 0,13166462 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07086991 0,13155835 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07086991 0,13145226 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,07086991 0,13134633 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07086991 0,13124058 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07086991 0,131135 ! androgen metabolic process GO:0008209 13 10 0,000 0,07086991 0,13102958 ! phospholipid efflux GO:0033700 16 10 0,000 0,07086991 0,13092434 ! hippocampus development GO:0021766 19 10 0,000 0,07086991 0,13081926 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07086991 0,13071435 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07086991 0,13060961 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07086991 0,13050504 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07086991 0,13040064 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07086991 0,1302964 ! pathogenesis GO:0009405 13 10 0,000 0,07086991 0,13019233 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07086991 0,13008843 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07086991 0,12998469 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07086991 0,12988112 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07086991 0,12977771 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07086991 0,12967446 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07086991 0,12957138 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07086991 0,12946847 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07086991 0,12936571 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07086991 0,12926312 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07086991 0,1291607 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07086991 0,12905843 ! response to X-ray GO:0010165 16 10 0,000 0,07086991 0,12895633 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07086991 0,12885439 ! forebrain cell migration GO:0021885 17 10 0,000 0,07086991 0,12875261 ! lipid digestion GO:0044241 15 10 0,000 0,07086991 0,12865099 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07086991 0,12854953 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07086991 0,12844823 ! UV protection GO:0009650 14 10 0,000 0,07086991 0,12834709 ! entry into host cell GO:0030260 20 10 0,000 0,07086991 0,12824611 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07086991 0,12814528 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07086991 0,12804462 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,07086991 0,12794411 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07086991 0,12784376 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07086991 0,12774357 ! regulation of organ growth GO:0046620 11 10 0,000 0,07086991 0,12764354 ! response to dsRNA GO:0043331 18 10 0,000 0,07086991 0,12754366 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07086991 0,12744394 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07086991 0,12734437 ! embryonic axis specification GO:0000578 12 10 0,000 0,07086991 0,12724496 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07086991 0,12714571 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07086991 0,12704661 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07086991 0,12694766 ! cranial nerve development GO:0021545 12 10 0,000 0,07086991 0,12684887 ! fucose catabolic process GO:0019317 16 10 0,000 0,07086991 0,12675023 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07086991 0,12665175 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07086991 0,12655342 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07086991 0,12645524 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07086991 0,12635721 ! zymogen activation GO:0031638 14 10 0,000 0,07086991 0,12625933 ! salivary gland development GO:0007431 22 10 0,000 0,07086991 0,12616161 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07086991 0,12606404 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07086991 0,12596661 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07086991 0,12586934 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07086991 0,12577222 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07086991 0,12567525 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07086991 0,12557843 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07086991 0,12548175 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07086991 0,12538523 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07086991 0,12528885 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07086991 0,12519263 ! detection of bacterium GO:0016045 10 10 0,000 0,07086991 0,12509655 ! embryonic gut development GO:0048566 11 10 0,000 0,07086991 0,12500061 ! activation of innate immune response GO:0002218 10 10 0,000 0,07086991 0,12490483 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07086991 0,12480919 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07086991 0,1247137 ! developmental induction GO:0031128 13 10 0,000 0,07086991 0,12461835 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07086991 0,12452315 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07086991 0,12442809 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07086991 0,12433318 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,07152866 0,12539324 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,07152866 0,12529774 GO:0035113|embryonic appendage morphogenesis, ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,07360994 0,12884541 ! extracellular matrix organization GO:0030198 103 61 1,000 0,07360994 0,12874743 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,07360994 0,12864959 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,07360994 0,12855191 ! respiratory tube development GO:0030323 99 62 1,000 0,0757106 0,13212017 ! organelle localization GO:0051640 96 62 1,000 0,0757106 0,13202 ! rRNA transcription GO:0009303 17 11 0,000 0,07767673 0,13534581 ! respiratory burst GO:0045730 14 11 0,000 0,07767673 0,13524335 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07767673 0,13514105 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07767673 0,1350389 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07767673 0,13493691 ! virus-host interaction GO:0019048 17 11 0,000 0,07767673 0,13483507 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,07767673 0,13473339 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07767673 0,13463185 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,07767673 0,13453048 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07767673 0,13442925 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07767673 0,13432817 ! mating GO:0007618 14 11 0,000 0,07767673 0,13422725 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07767673 0,13412648 ! T cell proliferation GO:0042098 20 11 0,000 0,07767673 0,13402586 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07767673 0,13392539 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07767673 0,13382507 ! bone resorption GO:0045453 16 11 0,000 0,07767673 0,1337249 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07767673 0,13362489 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07767673 0,13352502 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07767673 0,1334253 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07767673 0,13332572 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07767673 0,1332263 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07767673 0,13312703 ! syncytium formation GO:0006949 15 11 0,000 0,07767673 0,1330279 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07767673 0,13292892 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07767673 0,13283009 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07767673 0,13273141 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,07767673 0,13263287 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07767673 0,13253447 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07767673 0,13243623 ! adult heart development GO:0007512 11 11 0,000 0,07767673 0,13233813 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,07767673 0,13224017 ! temperature homeostasis GO:0001659 16 11 0,000 0,07767673 0,13214236 ! L-glutamate transport GO:0015813 16 11 0,000 0,07767673 0,13204469 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07767673 0,13194717 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07767673 0,13184979 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07767673 0,13175256 ! stem cell development GO:0048864 29 11 0,000 0,07767673 0,13165547 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07767673 0,13155852 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07767673 0,13146172 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07767673 0,13136505 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07767673 0,13126853 ! vasoconstriction GO:0042310 15 11 0,000 0,07767673 0,13117215 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07767673 0,13107591 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07767673 0,13097982 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07767673 0,13088386 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07767673 0,13078805 ! ribosome assembly GO:0042255 13 11 0,000 0,07767673 0,13069237 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07767673 0,13059684 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07767673 0,13050144 ! chromatin silencing GO:0006342 19 11 0,000 0,07767673 0,13040618 ! nucleosome positioning GO:0016584 13 11 0,000 0,07767673 0,13031107 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07767673 0,13021609 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,07767673 0,13012125 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07767673 0,13002654 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07767673 0,12993198 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07767673 0,12983755 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07767673 0,12974326 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07767673 0,12964911 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07767673 0,12955509 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07767673 0,12946121 ! male genitalia development GO:0030539 13 11 0,000 0,07767673 0,12936747 ! cholesterol efflux GO:0033344 19 11 0,000 0,07767673 0,12927386 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07767673 0,12918038 ! germ cell migration GO:0008354 18 11 0,000 0,07767673 0,12908705 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07767673 0,12899384 ! defense response to fungus GO:0050832 12 11 0,000 0,07767673 0,12890077 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07767673 0,12880784 ! lysogeny GO:0030069 18 11 0,000 0,07767673 0,12871504 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07767673 0,12862237 ! acrosome reaction GO:0007340 13 11 0,000 0,07767673 0,12852984 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07767673 0,12843743 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,07783026 0,12859884 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,07783026 0,12850653 ! regulation of lipase activity GO:0060191 109 63 1,000 0,07783026 0,12841434 ! appendage morphogenesis GO:0035107 93 64 1,000 0,07996852 0,13184774 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 1,000 0,07996852 0,13175329 ! adaptive immune response GO:0002250 94 64 1,000 0,07996852 0,13165898 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 1,000 0,08212501 0,13511268 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,08212501 0,1350161 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08212501 0,13491966 ! activation of immune response GO:0002253 83 65 1,000 0,08212501 0,13482336 ! lactation GO:0007595 20 12 0,000 0,08443406 0,13851522 ! reproductive cellular process GO:0048610 14 12 0,000 0,08443406 0,13841649 ! tRNA modification GO:0006400 14 12 0,000 0,08443406 0,13831791 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08443406 0,13821946 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08443406 0,13812115 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08443406 0,13802298 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08443406 0,13792496 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08443406 0,13782707 ! non-recombinational repair GO:0000726 19 12 0,000 0,08443406 0,13772932 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08443406 0,13763171 ! peroxisomal transport GO:0043574 21 12 0,000 0,08443406 0,13753423 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08443406 0,1374369 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08443406 0,1373397 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08443406 0,13724264 ! heart looping GO:0001947 15 12 0,000 0,08443406 0,13714572 ! palate development GO:0060021 15 12 0,000 0,08443406 0,13704893 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08443406 0,13695228 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08443406 0,13685577 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08443406 0,13675939 ! arginine metabolic process GO:0006525 13 12 0,000 0,08443406 0,13666315 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08443406 0,13656705 ! methionine metabolic process GO:0006555 13 12 0,000 0,08443406 0,13647107 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08443406 0,13637524 ! Golgi organization GO:0007030 18 12 0,000 0,08443406 0,13627954 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08443406 0,13618397 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08443406 0,13608853 ! monoamine transport GO:0015844 13 12 0,000 0,08443406 0,13599323 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08443406 0,13589807 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08443406 0,13580303 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08443406 0,13570813 ! L-amino acid transport GO:0015807 20 12 0,000 0,08443406 0,13561337 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08443406 0,13551873 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08443406 0,13542423 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08443406 0,13532985 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08443406 0,13523561 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08443406 0,1351415 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08443406 0,13504752 ! cerebellum development GO:0021549 13 12 0,000 0,08443406 0,13495368 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08443406 0,13485996 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08443406 0,13476637 ! histone acetylation GO:0016573 23 12 0,000 0,08443406 0,13467291 ! histone methylation GO:0016571 15 12 0,000 0,08443406 0,13457958 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08443406 0,13448638 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08443406 0,13439331 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08443406 0,13430037 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08443406 0,13420756 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08443406 0,13411488 ! intestinal absorption GO:0050892 19 12 0,000 0,08443406 0,13402232 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08443406 0,13392989 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08443406 0,13383759 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08443406 0,13374541 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08443406 0,13365336 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08443406 0,13356144 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08443406 0,13346965 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08443406 0,13337798 ! microspike assembly GO:0030035 23 12 0,000 0,08443406 0,13328644 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08443406 0,13319502 ! response to cold GO:0009409 14 12 0,000 0,08443406 0,13310373 ! acute inflammatory response GO:0002526 92 68 1,000 0,0887001 0,13973304 ! learning or memory GO:0007611 123 68 1,000 0,0887001 0,1396374 ! rhythmic process GO:0048511 105 68 1,000 0,0887001 0,13954188 ! response to drug GO:0042493 108 69 1,000 0,09092578 0,14294552 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09114227 0,14318799 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09114227 0,14309025 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09114227 0,14299265 ! regulation of chemokine production GO:0032642 17 13 0,000 0,09114227 0,14289518 ! water transport GO:0006833 17 13 0,000 0,09114227 0,14279784 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09114227 0,14270063 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09114227 0,14260355 ! lipid localization GO:0010876 24 13 0,000 0,09114227 0,14250661 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09114227 0,1424098 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09114227 0,14231312 ! organelle fusion GO:0048284 28 13 0,000 0,09114227 0,14221657 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09114227 0,14212015 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09114227 0,14202386 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09114227 0,14192771 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09114227 0,14183168 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,09114227 0,14173578 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09114227 0,14164002 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09114227 0,14154438 ! cytokine metabolic process GO:0042107 17 13 0,000 0,09114227 0,14144887 ! NAD metabolic process GO:0019674 21 13 0,000 0,09114227 0,14135349 ! exocrine system development GO:0035272 27 13 0,000 0,09114227 0,14125824 ! bone mineralization GO:0030282 15 13 0,000 0,09114227 0,14116311 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09114227 0,14106812 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09114227 0,14097325 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09114227 0,14087851 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09114227 0,1407839 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09114227 0,14068941 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,09114227 0,14059505 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,09114227 0,14050082 ! genitalia development GO:0048806 15 13 0,000 0,09114227 0,14040671 ! regulation of cellular pH GO:0030641 20 13 0,000 0,09114227 0,14031273 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,09114227 0,14021888 ! tissue regeneration GO:0042246 21 13 0,000 0,09114227 0,14012515 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09114227 0,14003155 ! cofactor transport GO:0051181 19 13 0,000 0,09114227 0,13993807 ! NADP metabolic process GO:0006739 18 13 0,000 0,09114227 0,13984471 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09114227 0,13975148 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09114227 0,13965838 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09114227 0,1395654 ! gas transport GO:0015669 18 13 0,000 0,09114227 0,13947254 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09114227 0,1393798 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09114227 0,13928719 ! regulation of axon extension GO:0030516 23 13 0,000 0,09114227 0,1391947 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09114227 0,13910234 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09114227 0,1390101 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09114227 0,13891797 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09114227 0,13882598 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09114227 0,1387341 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,09542595 0,14515852 ! response to hypoxia GO:0001666 132 72 1,000 0,09769973 0,14851909 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,09769973 0,148421 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,09780171 0,14847785 ! superoxide anion generation GO:0042554 18 14 0,000 0,09780171 0,14837991 ! neuron maturation GO:0042551 21 14 0,000 0,09780171 0,1482821 ! regulation of S phase GO:0033261 18 14 0,000 0,09780171 0,14818441 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09780171 0,14808686 ! myotube differentiation GO:0014902 21 14 0,000 0,09780171 0,14798943 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,09780171 0,14789214 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09780171 0,14779497 ! inositol metabolic process GO:0006020 20 14 0,000 0,09780171 0,14769792 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09780171 0,14760101 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09780171 0,14750422 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09780171 0,14740756 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09780171 0,14731103 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09780171 0,14721462 ! response to cAMP GO:0051591 19 14 0,000 0,09780171 0,14711834 ! limbic system development GO:0021761 25 14 0,000 0,09780171 0,14702218 ! startle response GO:0001964 21 14 0,000 0,09780171 0,14692615 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09780171 0,14683025 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09780171 0,14673447 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09780171 0,14663881 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09780171 0,14654328 ! glycine metabolic process GO:0006544 22 14 0,000 0,09780171 0,14644788 ! pituitary gland development GO:0021983 23 14 0,000 0,09780171 0,1463526 ! cellular response to starvation GO:0009267 21 14 0,000 0,09780171 0,14625744 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09780171 0,1461624 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09780171 0,14606749 ! regulation of heart rate GO:0002027 23 14 0,000 0,09780171 0,14597271 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09780171 0,14587804 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09780171 0,1457835 ! embryo implantation GO:0007566 27 14 0,000 0,09780171 0,14568908 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,09780171 0,14559478 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,09780171 0,14550061 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09780171 0,14540655 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09780171 0,14531262 ! axon cargo transport GO:0008088 27 14 0,000 0,09780171 0,14521881 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09780171 0,14512512 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09780171 0,14503155 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09780171 0,14493811 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09780171 0,14484478 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09780171 0,14475157 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09780171 0,14465848 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09780171 0,14456551 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09780171 0,14447267 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09780171 0,14437994 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09780171 0,14428733 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09780171 0,14419483 ! muscle maintenance GO:0046716 19 14 0,000 0,09780171 0,14410246 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09780171 0,1440102 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09780171 0,14391807 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09780171 0,14382605 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09780171 0,14373415 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09780171 0,14364236 ! cilium assembly GO:0042384 20 14 0,000 0,09780171 0,1435507 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09780171 0,14345915 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,09998886 0,14657385 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,09998886 0,14648049 ! response to oxygen levels GO:0070482 137 74 1,000 0,10229297 0,14976056 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,10229297 0,14966529 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10441274 0,15266961 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10441274 0,15257262 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10441274 0,15247574 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10441274 0,152379 ! lipid phosphorylation GO:0046834 23 15 0,000 0,10441274 0,15228237 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,10441274 0,15218587 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10441274 0,15208948 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10441274 0,15199323 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10441274 0,15189709 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10441274 0,15180107 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10441274 0,15170518 ! adult walking behavior GO:0007628 25 15 0,000 0,10441274 0,1516094 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10441274 0,15151375 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10441274 0,15141822 ! myoblast differentiation GO:0045445 27 15 0,000 0,10441274 0,15132281 ! centrosome cycle GO:0007098 16 15 0,000 0,10441274 0,15122752 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10441274 0,15113235 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10441274 0,15103729 ! cerebral cortex development GO:0021987 29 15 0,000 0,10441274 0,15094236 ! response to osmotic stress GO:0006970 22 15 0,000 0,10441274 0,15084755 ! vesicle coating GO:0006901 25 15 0,000 0,10441274 0,15075285 ! DNA integration GO:0015074 22 15 0,000 0,10441274 0,15065828 ! peptide secretion GO:0002790 27 15 0,000 0,10441274 0,15056382 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10441274 0,15046948 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10441274 0,15037526 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10441274 0,15028116 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10441274 0,15018718 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10441274 0,15009331 ! biomineral formation GO:0031214 18 15 0,000 0,10441274 0,14999956 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10441274 0,14990593 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10441274 0,14981241 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10441274 0,14971901 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10441274 0,14962573 ! organic cation transport GO:0015695 19 15 0,000 0,10441274 0,14953256 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10441274 0,14943951 GO:0033014|tetrapyrrole biosynthetic process, ! peptide hormone processing GO:0016486 19 15 0,000 0,10441274 0,14934658 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10441274 0,14925376 ! blood coagulation GO:0007596 116 75 1,000 0,10461175 0,14944536 GO:0050817|coagulation, ! response to unfolded protein GO:0006986 99 76 1,000 0,10694485 0,15268352 ! regulation of protein transport GO:0051223 114 76 1,000 0,10694485 0,1525888 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,10929194 0,15584096 ! regulation of DNA binding GO:0051101 119 77 1,000 0,10929194 0,1557444 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,10929194 0,15564796 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,10929194 0,15555165 ! protein secretion GO:0009306 27 16 0,000 0,11097569 0,1578504 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11097569 0,15775284 ! hormone secretion GO:0046879 25 16 0,000 0,11097569 0,1576554 ! bone remodeling GO:0046849 24 16 0,000 0,11097569 0,15755809 ! endothelial cell migration GO:0043542 22 16 0,000 0,11097569 0,15746089 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11097569 0,15736381 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11097569 0,15726685 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11097569 0,15717001 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11097569 0,15707329 ! glial cell development GO:0021782 24 16 0,000 0,11097569 0,15697669 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11097569 0,15688021 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11097569 0,15678384 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11097569 0,1566876 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11097569 0,15659147 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11097569 0,15649546 ! fructose metabolic process GO:0006000 20 16 0,000 0,11097569 0,15639957 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11097569 0,1563038 ! protein export from nucleus GO:0006611 24 16 0,000 0,11097569 0,15620814 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11097569 0,1561126 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11097569 0,15601717 ! DNA replication initiation GO:0006270 25 16 0,000 0,11097569 0,15592187 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11097569 0,15582668 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11097569 0,1557316 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11097569 0,15563664 ! diencephalon development GO:0021536 25 16 0,000 0,11097569 0,1555418 ! neural crest cell migration GO:0001755 24 16 0,000 0,11097569 0,15544708 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11097569 0,15535246 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11097569 0,15525797 ! steroid catabolic process GO:0006706 22 16 0,000 0,11097569 0,15516359 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,11097569 0,15506932 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11097569 0,15497517 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11097569 0,15488113 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11097569 0,1547872 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11097569 0,15469339 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11097569 0,1545997 ! nerve development GO:0021675 18 16 0,000 0,11097569 0,15450611 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11097569 0,15441264 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11097569 0,15431929 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,1116527 0,1551669 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,11402681 0,15837057 ! T cell activation GO:0042110 134 79 1,000 0,11402681 0,15827499 ! regulation of lyase activity GO:0051339 133 79 1,000 0,11402681 0,15817953 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,11641394 0,16139365 GO:0010498|proteasomal protein catabolic process, ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11749093 0,16278864 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11749093 0,16269063 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11749093 0,16259274 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11749093 0,16249497 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11749093 0,16239732 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11749093 0,16229978 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11749093 0,16220237 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11749093 0,16210506 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11749093 0,16200788 ! signal complex assembly GO:0007172 29 17 0,000 0,11749093 0,16191081 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11749093 0,16181386 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11749093 0,16171702 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11749093 0,1616203 ! memory GO:0007613 25 17 0,000 0,11749093 0,16152369 ! keratinization GO:0031424 17 17 0,000 0,11749093 0,1614272 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11749093 0,16133083 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11749093 0,16123457 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11749093 0,16113843 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11749093 0,1610424 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11749093 0,16094648 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11749093 0,16085068 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,11749093 0,16075499 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11749093 0,16065942 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11749093 0,16056396 ! membrane budding GO:0006900 29 17 0,000 0,11749093 0,16046861 ! heme metabolic process GO:0042168 27 17 0,000 0,11749093 0,16037338 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,11749093 0,16027826 ! stem cell differentiation GO:0048863 36 17 0,000 0,11749093 0,16018325 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11749093 0,16008835 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11749093 0,15999357 ! sensory perception of pain GO:0019233 23 17 0,000 0,11749093 0,1598989 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11749093 0,15980434 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11749093 0,15970989 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,11749093 0,15961556 ! synaptogenesis GO:0007416 24 17 0,000 0,11749093 0,15952133 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11749093 0,15942722 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11749093 0,15933322 ! cell-cell junction organization GO:0045216 25 17 0,000 0,11749093 0,15923933 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11749093 0,15914555 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,11749093 0,15905188 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11749093 0,15895832 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11749093 0,15886487 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,11881379 0,16055918 ! hemostasis GO:0007599 125 81 1,000 0,11881379 0,1604649 ! detection of stimulus GO:0051606 108 82 1,000 0,12122604 0,1636267 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,12365039 0,16680112 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12395879 0,16711912 ! positive regulation of translation GO:0045727 28 18 0,000 0,12395879 0,16702122 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12395879 0,16692343 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12395879 0,16682576 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12395879 0,1667282 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12395879 0,16663075 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12395879 0,16653342 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12395879 0,1664362 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12395879 0,1663391 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12395879 0,16624211 ! axis specification GO:0009798 26 18 0,000 0,12395879 0,16614523 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12395879 0,16604847 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12395879 0,16595181 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12395879 0,16585527 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12395879 0,16575885 ! response to retinoic acid GO:0032526 25 18 0,000 0,12395879 0,16566253 ! pigmentation during development GO:0048066 31 18 0,000 0,12395879 0,16556633 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12395879 0,16547024 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,12395879 0,16537426 ! fucose metabolic process GO:0006004 26 18 0,000 0,12395879 0,16527839 ! response to fungus GO:0009620 19 18 0,000 0,12395879 0,16518263 ! peptide cross-linking GO:0018149 31 18 0,000 0,12395879 0,16508698 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12395879 0,16499144 ! heart process GO:0003015 27 18 0,000 0,12395879 0,16489602 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12395879 0,1648007 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12395879 0,1647055 ! somitogenesis GO:0001756 24 18 0,000 0,12395879 0,1646104 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12395879 0,16451542 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12395879 0,16442054 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12395879 0,16432577 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,12395879 0,16423112 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12395879 0,16413657 ! vitamin transport GO:0051180 24 18 0,000 0,12395879 0,16404213 ! hormone transport GO:0009914 27 18 0,000 0,12395879 0,1639478 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12395879 0,16385357 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12395879 0,16375946 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12395879 0,16366545 ! cell-cell recognition GO:0009988 20 18 0,000 0,12395879 0,16357155 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12395879 0,16347776 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12395879 0,16338408 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,12395879 0,1632905 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,12853418 0,16922072 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,12853418 0,16912392 ! transcription initiation GO:0006352 118 85 1,000 0,12853418 0,16902722 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,12853418 0,16893063 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13037961 0,1712582 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,13037961 0,17116045 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,13037961 0,17106281 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13037961 0,17096529 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13037961 0,17086787 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,13037961 0,17077057 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13037961 0,17067337 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13037961 0,17057629 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13037961 0,17047931 ! sensory perception of taste GO:0050909 23 19 0,000 0,13037961 0,17038245 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,13037961 0,1702857 ! peroxisome organization GO:0007031 29 19 0,000 0,13037961 0,17018905 ! digestive system process GO:0022600 30 19 0,000 0,13037961 0,17009252 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13037961 0,1699961 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13037961 0,16989978 ! response to vitamin A GO:0033189 26 19 0,000 0,13037961 0,16980357 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13037961 0,16970748 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13037961 0,16961149 ! response to starvation GO:0042594 30 19 0,000 0,13037961 0,16951561 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13037961 0,16941984 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13037961 0,16932417 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,13037961 0,16922862 ! cytolysis GO:0019835 20 19 0,000 0,13037961 0,16913317 ! vasodilation GO:0042311 33 19 0,000 0,13037961 0,16903783 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13037961 0,1689426 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13037961 0,16884747 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13037961 0,16875245 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13037961 0,16865754 ! sarcomere organization GO:0045214 23 19 0,000 0,13037961 0,16856274 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13037961 0,16846804 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13037961 0,16837345 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13037961 0,16827896 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13037961 0,16818458 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13037961 0,16809031 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,13037961 0,16799614 ! protein stabilization GO:0050821 26 19 0,000 0,13037961 0,16790208 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,13099302 0,16859761 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,13346276 0,17168029 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 1,000 0,13346276 0,17158433 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,13346276 0,17148847 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,13594313 0,174578 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13675374 0,17552099 ! iron ion transport GO:0006826 37 20 0,000 0,13675374 0,17542309 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13675374 0,17532531 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13675374 0,17522764 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13675374 0,17513007 ! response to vitamin GO:0033273 29 20 0,000 0,13675374 0,17503261 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13675374 0,17493527 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13675374 0,17483803 ! spinal cord development GO:0021510 31 20 0,000 0,13675374 0,17474089 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,13675374 0,17464387 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13675374 0,17454695 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13675374 0,17445014 ! chromosome condensation GO:0030261 31 20 0,000 0,13675374 0,17435344 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13675374 0,17425685 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13675374 0,17416036 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13675374 0,17406398 ! pallium development GO:0021543 38 20 0,000 0,13675374 0,1739677 ! DNA modification GO:0006304 28 20 0,000 0,13675374 0,17387154 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13675374 0,17377547 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13675374 0,17367952 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,13675374 0,17358367 ! collagen catabolic process GO:0030574 25 20 0,000 0,13675374 0,17348793 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13675374 0,17339229 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,13675374 0,17329675 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13675374 0,17320133 ! alditol metabolic process GO:0019400 24 20 0,000 0,13675374 0,173106 ! actin filament-based movement GO:0030048 34 20 0,000 0,13675374 0,17301079 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,13843384 0,17504004 ! leukocyte differentiation GO:0002521 143 90 1,000 0,1409346 0,17810416 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,1409346 0,17800636 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,14308151 0,18061881 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14308151 0,18051974 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14308151 0,18042077 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14308151 0,18032191 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14308151 0,18022315 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14308151 0,18012451 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,14308151 0,18002597 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14308151 0,17992754 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14308151 0,17982922 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14308151 0,17973101 ! protein amino acid acylation GO:0043543 37 21 0,000 0,14308151 0,1796329 ! vesicle docking GO:0048278 27 21 0,000 0,14308151 0,1795349 ! phototransduction GO:0007602 25 21 0,000 0,14308151 0,17943701 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14308151 0,17933923 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14308151 0,17924155 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14308151 0,17914397 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14308151 0,17904651 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,14308151 0,17894915 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14308151 0,17885189 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14308151 0,17875474 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14308151 0,1786577 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14308151 0,17856076 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14308151 0,17846393 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14308151 0,1783672 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14308151 0,17827057 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14308151 0,17817405 ! fatty acid transport GO:0015908 30 21 0,000 0,14308151 0,17807764 ! immunoglobulin production GO:0002377 33 21 0,000 0,14308151 0,17798133 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,14308151 0,17788512 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14308151 0,17778902 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14308151 0,17769302 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14308151 0,17759713 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,14308151 0,17750134 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14308151 0,17740565 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14308151 0,17731006 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14308151 0,17721458 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14308151 0,1771192 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14308151 0,17702393 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14308151 0,17692875 ! response to virus GO:0009615 122 91 1,000 0,14344513 0,17728308 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,14596518 0,1803007 ! cell fate commitment GO:0045165 141 92 1,000 0,14596518 0,18020392 ! positive regulation of immune response GO:0050778 121 92 1,000 0,14596518 0,18010724 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,14849445 0,18312988 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,14936326 0,18410262 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,14936326 0,18400401 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,14936326 0,18390551 ! viral genome replication GO:0019079 29 22 0,000 0,14936326 0,18380711 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14936326 0,18370882 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14936326 0,18361063 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14936326 0,18351255 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,14936326 0,18341457 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14936326 0,1833167 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,14936326 0,18321893 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,14936326 0,18312127 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,14936326 0,18302371 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14936326 0,18292625 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,14936326 0,1828289 ! lysosome organization GO:0007040 37 22 0,000 0,14936326 0,18273165 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,14936326 0,1826345 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,14936326 0,18253746 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14936326 0,18244052 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14936326 0,18234368 ! membrane depolarization GO:0051899 35 22 0,000 0,14936326 0,18224695 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14936326 0,18215032 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,14936326 0,18205379 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14936326 0,18195736 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14936326 0,18186104 ! blastocyst development GO:0001824 37 22 0,000 0,14936326 0,18176481 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14936326 0,18166869 ! protein tetramerization GO:0051262 39 22 0,000 0,14936326 0,18157267 ! response to oxidative stress GO:0006979 141 94 1,000 0,15103269 0,18350512 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,15559931 0,18895376 ! neuron fate commitment GO:0048663 32 23 0,000 0,15559931 0,18885405 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15559931 0,18875444 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15559931 0,18865494 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,15559931 0,18855554 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,15559931 0,18845625 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,15559931 0,18835706 ! vesicle targeting GO:0006903 32 23 0,000 0,15559931 0,18825798 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,15559931 0,188159 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15559931 0,18806013 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15559931 0,18796135 ! interaction with host GO:0051701 37 23 0,000 0,15559931 0,18786269 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,15559931 0,18776412 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15559931 0,18766566 ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15559931 0,18756731 ! cell fate determination GO:0001709 45 23 0,000 0,15559931 0,18746905 ! pentose metabolic process GO:0019321 31 23 0,000 0,15559931 0,1873709 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15559931 0,18727285 ! spermatid development GO:0007286 33 23 0,000 0,15559931 0,18717491 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15559931 0,18707706 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15559931 0,18697932 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15559931 0,18688168 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15559931 0,18678414 ! telomere organization GO:0032200 32 23 0,000 0,15559931 0,18668671 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,15559931 0,18658937 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,15559931 0,18649214 ! regulation of amine transport GO:0051952 38 23 0,000 0,15559931 0,18639501 ! liver development GO:0001889 40 23 0,000 0,15559931 0,18629798 ! in utero embryonic development GO:0001701 147 96 1,000 0,15613501 0,18684211 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,15613501 0,18674495 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,15613501 0,18664789 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16179 0,19330754 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,16179 0,19320717 ! initiation of viral infection GO:0019059 42 24 0,000 0,16179 0,19310691 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16179 0,19300675 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,16179 0,19290669 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16179 0,19280674 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16179 0,19270689 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,16179 0,19260715 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16179 0,19250751 ! sperm motility GO:0030317 27 24 0,000 0,16179 0,19240797 ! vacuole organization GO:0007033 39 24 0,000 0,16179 0,19230853 ! receptor metabolic process GO:0043112 37 24 0,000 0,16179 0,1922092 ! neural crest cell development GO:0014032 39 24 0,000 0,16179 0,19210997 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 56 24 0,000 0,16179 0,19201084 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16179 0,19191182 ! base-excision repair GO:0006284 31 24 0,000 0,16179 0,19181289 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16179 0,19171407 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16179 0,19161535 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,16179 0,19151673 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16179 0,19141822 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,16179 0,1913198 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16179 0,19122149 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,16643587 0,19661145 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,16793566 0,19828133 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,16793566 0,19817959 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16793566 0,19807796 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,16793566 0,19797643 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,16793566 0,19787501 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,16793566 0,19777369 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,16793566 0,19767248 ! peptide transport GO:0015833 43 25 0,000 0,16793566 0,19757137 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16793566 0,19747036 ! phospholipid transport GO:0015914 35 25 0,000 0,16793566 0,19736945 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,16793566 0,19726865 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,16793566 0,19716795 ! detection of light stimulus GO:0009583 30 25 0,000 0,16793566 0,19706736 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,16793566 0,19696686 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17403661 0,20401845 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,17403661 0,20391452 ! translational initiation GO:0006413 43 26 0,000 0,17403661 0,20381069 ! regulation of pH GO:0006885 36 26 0,000 0,17403661 0,20370697 ! circadian rhythm GO:0007623 42 26 0,000 0,17403661 0,20360336 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17403661 0,20349985 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17403661 0,20339644 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17403661 0,20329314 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17403661 0,20318995 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,17403661 0,20308686 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17403661 0,20298387 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17403661 0,20288099 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17403661 0,20277822 ! regulation of coagulation GO:0050818 39 26 0,000 0,17403661 0,20267554 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18009317 0,20962262 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,18009317 0,20951659 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18009317 0,20941066 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18009317 0,20930485 ! membrane docking GO:0022406 39 27 0,000 0,18009317 0,20919914 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18009317 0,20909353 ! catechol metabolic process GO:0009712 43 27 0,000 0,18009317 0,20898804 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18009317 0,20888265 ! acute-phase response GO:0006953 42 27 0,000 0,18009317 0,20877736 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18009317 0,20867219 ! myofibril assembly GO:0030239 36 27 0,000 0,18009317 0,20856711 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18009317 0,20846215 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,18009317 0,20835729 ! natural killer cell activation GO:0030101 35 27 0,000 0,18009317 0,20825253 ! lipid oxidation GO:0034440 38 27 0,000 0,18009317 0,20814788 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18009317 0,20804334 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18009317 0,2079389 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,18009317 0,20783457 ! gene silencing GO:0016458 41 27 0,000 0,18009317 0,20773034 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,18610566 0,21455791 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18610566 0,21445041 ! phenol metabolic process GO:0018958 44 28 0,000 0,18610566 0,21434303 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,18610566 0,21423575 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18610566 0,21412858 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18610566 0,21402151 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18610566 0,21391455 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18610566 0,2138077 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18610566 0,21370096 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18610566 0,21359432 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18610566 0,21348779 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18610566 0,21338137 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18610566 0,21327505 ! mesoderm formation GO:0001707 46 28 0,000 0,18610566 0,21316884 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18610566 0,21306273 ! BMP signaling pathway GO:0030509 40 28 0,000 0,18610566 0,21295673 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18610566 0,21285083 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,18610566 0,21274504 ! placenta development GO:0001890 37 28 0,000 0,18610566 0,21263936 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19207441 0,21935012 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,19207441 0,21924126 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19207441 0,21913251 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,19207441 0,21902387 ! mismatch repair GO:0006298 34 29 0,000 0,19207441 0,21891533 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,19207441 0,2188069 ! muscle cell development GO:0055001 38 29 0,000 0,19207441 0,21869858 ! formation of primary germ layer GO:0001704 48 29 0,000 0,19207441 0,21859037 ! telencephalon development GO:0021537 52 29 0,000 0,19207441 0,21848226 ! eye morphogenesis GO:0048592 51 29 0,000 0,19207441 0,21837426 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19207441 0,21826637 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,19799972 0,22488857 ! collagen metabolic process GO:0032963 40 30 0,000 0,19799972 0,22477757 ! organic anion transport GO:0015711 51 30 0,000 0,19799972 0,22466668 ! cholesterol transport GO:0030301 46 30 0,000 0,19799972 0,2245559 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,19799972 0,22444522 ! spliceosome assembly GO:0000245 49 30 0,000 0,19799972 0,22433466 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19799972 0,2242242 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,19799972 0,22411386 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19799972 0,22400362 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19799972 0,22389349 ! adult locomotory behavior GO:0008344 47 30 0,000 0,19799972 0,22378347 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,19799972 0,22367355 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,19799972 0,22356375 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19799972 0,22345405 ! negative regulation of secretion GO:0051048 49 31 0,000 0,20388191 0,2299796 ! glial cell differentiation GO:0010001 55 31 0,000 0,20388191 0,22986686 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,20388191 0,22975424 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20388191 0,22964172 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,20388191 0,22952932 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,20388191 0,22941703 ! segmentation GO:0035282 41 31 0,000 0,20388191 0,22930484 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,20388191 0,22919277 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,20388191 0,2290808 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20388191 0,22896895 ! cell fate specification GO:0001708 37 31 0,000 0,20388191 0,2288572 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,20388191 0,22874556 ! RNA modification GO:0009451 40 31 0,000 0,20388191 0,22863403 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,2097213 0,23506773 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,2097213 0,23495323 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,2097213 0,23483884 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,2097213 0,23472457 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,2097213 0,2346104 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,2097213 0,23449635 ! cytokine production GO:0001816 44 32 0,000 0,2097213 0,2343824 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,2097213 0,23426857 ! vesicle localization GO:0051648 47 32 0,000 0,2097213 0,23415485 ! RNA export from nucleus GO:0006405 44 33 0,000 0,21551819 0,24051035 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,21551819 0,24039371 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,21551819 0,24027718 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,21551819 0,24016077 ! actomyosin structure organization GO:0031032 43 33 0,000 0,21551819 0,24004447 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,21551819 0,23992828 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,21551819 0,2398122 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,21551819 0,23969624 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,21551819 0,23958039 ! lipid homeostasis GO:0055088 55 33 0,000 0,21551819 0,23946465 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,21551819 0,23934902 ! regulation of proteolysis GO:0030162 50 33 0,000 0,21551819 0,23923351 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,21551819 0,2391181 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,21551819 0,23900281 ! mRNA catabolic process GO:0006402 48 34 0,000 0,22127288 0,24526632 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,22127288 0,24514818 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,22127288 0,24503015 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,22127288 0,24491223 ! feeding behavior GO:0007631 45 34 0,000 0,22127288 0,24479443 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,22127288 0,24467674 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,22127288 0,24455917 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,22127288 0,2444417 ! polyol metabolic process GO:0019751 44 34 0,000 0,22127288 0,24432435 ! aerobic respiration GO:0009060 47 34 0,000 0,22127288 0,24420711 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,22127288 0,24408999 ! embryonic organ development GO:0048568 45 34 0,000 0,22127288 0,24397297 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,22127288 0,24385607 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,22698569 0,25003213 ! Notch signaling pathway GO:0007219 56 35 0,000 0,22698569 0,24991244 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,22698569 0,24979286 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,22698569 0,2496734 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,22698569 0,24955405 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,22698569 0,24943482 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,22698569 0,2493157 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,22698569 0,2491967 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,22698569 0,24907781 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,23265691 0,25517925 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,23265691 0,25505762 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,23265691 0,25493611 ! tissue remodeling GO:0048771 62 36 0,000 0,23265691 0,25481471 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,23265691 0,25469343 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23265691 0,25457226 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,23265691 0,25445121 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,23828685 0,26048467 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23828685 0,26036093 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23828685 0,2602373 ! regulation of protein secretion GO:0050708 51 37 0,000 0,23828685 0,26011379 ! amino acid activation GO:0043038 52 37 0,000 0,23828685 0,2599904 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23828685 0,25986712 ! gliogenesis GO:0042063 71 38 0,000 0,2438758 0,26583618 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,2438758 0,26571025 ! maintenance of location in cell GO:0051651 69 38 0,000 0,2438758 0,26558444 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,24942407 0,27149804 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,24942407 0,27136961 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,24942407 0,2712413 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,24942407 0,27111312 ! chromatin remodeling GO:0006338 68 39 0,000 0,24942407 0,27098505 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,24942407 0,27085711 ! JNK cascade GO:0007254 54 39 0,000 0,24942407 0,27072928 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,25493193 0,2765771 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,25493193 0,2764467 ! regulation of tube size GO:0035150 60 40 0,000 0,25493193 0,27631642 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,25493193 0,27618627 ! peptide metabolic process GO:0006518 56 40 0,000 0,25493193 0,27605624 ! inner ear development GO:0048839 57 40 0,000 0,25493193 0,27592633 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,25493193 0,27579654 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,25493193 0,27566688 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,25493193 0,27553733 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,25493193 0,27540791 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,2603997 0,28118277 ! endosome transport GO:0016197 71 41 0,000 0,2603997 0,28105082 ! striated muscle contraction GO:0006941 62 41 0,000 0,2603997 0,280919 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,2603997 0,28078729 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,2603997 0,28065572 ! biopolymer methylation GO:0043414 62 41 0,000 0,2603997 0,28052426 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,26582764 0,28623763 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,26582764 0,28610369 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,26582764 0,28596987 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,26582764 0,28583618 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,26582764 0,28570261 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,26582764 0,28556916 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,26582764 0,28543584 ! regulation of cell shape GO:0008360 78 42 0,000 0,26582764 0,28530265 ! positive regulation of binding GO:0051099 59 43 0,000 0,27121606 0,29095007 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,27121606 0,29081443 ! neuromuscular process GO:0050905 79 43 0,000 0,27121606 0,29067891 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,27121606 0,29054352 ! tRNA processing GO:0008033 49 43 0,000 0,27121606 0,29040826 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,27121606 0,29027313 ! methylation GO:0032259 64 43 0,000 0,27121606 0,29013811 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,27656524 0,29572295 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,27656524 0,29558553 ! glycolysis GO:0006096 53 44 0,000 0,27656524 0,29544824 ! regulation of ion transport GO:0043269 57 44 0,000 0,27656524 0,29531108 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,27656524 0,29517404 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,27656524 0,29503713 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,27656524 0,29490035 ! RNA catabolic process GO:0006401 64 45 0,000 0,28187547 0,30042334 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28187547 0,30028419 ! cell maturation GO:0048469 60 45 0,000 0,28187547 0,30014517 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,28714701 0,3056169 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,28714701 0,30547554 ! cell redox homeostasis GO:0045454 63 46 0,000 0,28714701 0,30533432 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,28714701 0,30519322 ! histone modification GO:0016570 68 46 0,000 0,28714701 0,30505225 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,28714701 0,30491142 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,29238016 0,31032504 ! viral infectious cycle GO:0019058 71 47 0,000 0,29238016 0,3101819 ! covalent chromatin modification GO:0016569 75 47 0,000 0,29238016 0,3100389 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,29238016 0,30989602 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,29238016 0,30975328 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,29238016 0,30961067 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,29238016 0,30946819 ! chloride transport GO:0006821 67 48 0,000 0,29757519 0,31482196 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,29757519 0,31467721 ! gastrulation GO:0007369 73 48 0,000 0,29757519 0,3145326 ! heart morphogenesis GO:0003007 65 48 0,000 0,29757519 0,31438812 ! regulation of DNA replication GO:0006275 75 48 0,000 0,29757519 0,31424377 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,29757519 0,31409956 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,29757519 0,31395548 ! regulation of endocytosis GO:0030100 63 48 0,000 0,29757519 0,31381152 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,29757519 0,31366771 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,30273238 0,31895761 ! sensory perception of smell GO:0007608 61 49 0,000 0,30273238 0,31881157 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,30273238 0,31866566 ! RNA elongation GO:0006354 62 49 0,000 0,30273238 0,31851988 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,30273238 0,31837424 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,30273238 0,31822873 ! maintenance of location GO:0051235 84 49 0,000 0,30273238 0,31808335 ! regulation of actin filament length GO:0030832 72 50 0,000 0,30785199 0,32331488 ! membrane fusion GO:0006944 80 50 0,000 0,30785199 0,32316731 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,30785199 0,32301988 ! lipid modification GO:0030258 73 50 0,000 0,30785199 0,32287258 ! proton transport GO:0015992 75 50 0,000 0,30785199 0,32272542 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,30785199 0,3225784 ! positive regulation of secretion GO:0051047 71 51 0,000 0,31293431 0,32775451 ! hydrogen transport GO:0006818 77 51 0,000 0,31293431 0,32760533 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,31293431 0,32745628 ! adult behavior GO:0030534 80 51 0,000 0,31293431 0,32730737 ! transition metal ion transport GO:0000041 74 52 0,000 0,31797959 0,33243321 ! regulation of cellular component size GO:0032535 74 52 0,000 0,31797959 0,33228218 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,31797959 0,33213128 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,31797959 0,33198051 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,32298812 0,33705657 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,32298812 0,33690371 ! single fertilization GO:0007338 59 53 0,000 0,32298812 0,33675099 ! cell projection assembly GO:0030031 76 53 0,000 0,32298812 0,3365984 ! amino acid transport GO:0006865 84 54 0,000 0,32796015 0,34162516 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,32796015 0,34147051 ! glucose catabolic process GO:0006007 66 54 0,000 0,32796015 0,34131599 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,32796015 0,34116162 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,32796015 0,34100739 ! exocytosis GO:0006887 74 55 0,000 0,33289595 0,34598314 ! mesoderm development GO:0007498 76 55 0,000 0,33289595 0,34582687 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,33289595 0,34567074 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,3426599 0,35564881 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,3426599 0,35548839 ! developmental maturation GO:0021700 75 57 0,000 0,3426599 0,35532812 ! viral reproductive process GO:0022415 87 58 0,000 0,34748857 0,36017292 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,34748857 0,36001068 ! activation of MAPK activity GO:0000187 84 59 0,000 0,35228204 0,36481256 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,35704057 0,36957395 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,35704057 0,3694077 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,35704057 0,3692416 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,35704057 0,36907565 ! fertilization GO:0009566 68 60 0,000 0,35704057 0,36890984 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,36176441 0,37362288 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,36176441 0,37345519 ! amine catabolic process GO:0009310 90 62 0,000 0,36645382 0,37812642 ! neurotransmitter transport GO:0006836 81 62 0,000 0,36645382 0,37795686 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,36645382 0,37778744 ! viral reproduction GO:0016032 92 63 0,000 0,37110904 0,38241523 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,37573032 0,38700391 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,37573032 0,38683068 ! hexose catabolic process GO:0019320 82 64 0,000 0,37573032 0,3866576 ! defense response to bacterium GO:0042742 73 65 0,000 0,3803179 0,39120357 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,3803179 0,39102869 ! protein oligomerization GO:0051259 100 65 0,000 0,3803179 0,39085396 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,38487203 0,3953576 ! antigen processing and presentation GO:0019882 96 66 0,000 0,38487203 0,3951811 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,38487203 0,39500476 ! regulation of immune effector process GO:0002697 101 66 0,000 0,38487203 0,39482858 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,38939295 0,39928836 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,39388091 0,40371038 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,39388091 0,40353055 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,39388091 0,40335088 ! inorganic anion transport GO:0015698 93 68 0,000 0,39388091 0,40317138 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,39833613 0,40755031 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,39833613 0,4073691 ! amine transport GO:0015837 101 70 0,000 0,40275886 0,41170906 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,40275886 0,41152615 ! regulation of catabolic process GO:0009894 106 70 0,000 0,40275886 0,41134342 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,40714933 0,4156429 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,40714933 0,4154585 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,42012951 0,42851347 ! digestion GO:0007586 97 74 0,000 0,42012951 0,42832353 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,42012951 0,42813375 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,42439327 0,43228721 ! amine biosynthetic process GO:0009309 97 76 0,000 0,42862591 0,43640531 ! tRNA metabolic process GO:0006399 95 76 0,000 0,42862591 0,43621221 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,42862591 0,43601928 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,43282768 0,44009887 ! protein ubiquitination GO:0016567 125 77 0,000 0,43282768 0,4399044 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,43699878 0,44394752 ! cellular respiration GO:0045333 107 79 0,000 0,44113945 0,44795617 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,44113945 0,44775848 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,44113945 0,44756097 ! chromatin assembly GO:0031497 102 80 0,000 0,44524989 0,45153208 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,44524989 0,45133308 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,44524989 0,45113425 ! mRNA transport GO:0051028 121 81 0,000 0,44933035 0,45506816 ! vitamin metabolic process GO:0006766 103 81 0,000 0,44933035 0,45486787 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,44933035 0,45466775 GO:0002696|positive regulation of leukocyte activation, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,45740212 0,46263187 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,46139388 0,46646414 ! sterol metabolic process GO:0016125 120 84 0,000 0,46139388 0,46625919 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,46535649 0,47005706 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,46535649 0,46985072 ! nucleosome organization GO:0034728 114 87 0,000 0,47319515 0,47755544 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,47319515 0,47734598 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,47319515 0,47713671 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,47707161 0,48083466 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,47707161 0,48062405 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,47707161 0,48041362 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,48091977 0,48407679 ! hormone metabolic process GO:0042445 121 90 0,000 0,48473982 0,48770848 ! RNA localization GO:0006403 135 91 0,000 0,48853199 0,49130895 ! ATP metabolic process GO:0046034 137 91 0,000 0,48853199 0,49109422 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,49229646 0,49466223 ! sulfur metabolic process GO:0006790 118 92 0,000 0,49229646 0,49444622 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,49603344 0,49798206 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,49603344 0,49776479 ! electron transport chain GO:0022900 123 94 0,000 0,49974312 0,50126872 ! angiogenesis GO:0001525 149 95 0,000 0,50342571 0,50474243 ! carboxylic acid transport GO:0046942 147 95 0,000 0,50342571 0,5045225 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,5070814 0,50796482 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,51071039 0,5113774 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,51071039 0,51115487 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,52143906 0,52166587 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,52143906 0,52143906