pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6885-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! spindle assembly GO:0051225 6 5 3,000 5,142E-09 1,256E-05 ! induction of positive chemotaxis GO:0050930 17 9 3,000 1,273E-07 1,555E-04 ! positive regulation of locomotion GO:0040017 44 22 4,000 1,407E-07 1,146E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 45 23 4,000 1,79E-07 1,093E-04 ! natural killer cell mediated immunity GO:0002228 19 10 3,000 2,112E-07 1,032E-04 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of behavior GO:0050795 48 25 4,000 2,8E-07 1,14E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 3,000 3,303E-07 1,153E-04 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 4,933E-07 1,506E-04 GO:0050927|positive regulation of positive chemotaxis, ! leukocyte mediated cytotoxicity GO:0001909 28 12 3,000 4,933E-07 1,339E-04 ! cell killing GO:0001906 32 15 3,000 1,342E-06 3,279E-04 ! polyol catabolic process GO:0046174 9 5 2,000 1,82E-06 4,042E-04 GO:0019405|alditol catabolic process, ! ganglioside catabolic process GO:0006689 12 5 2,000 1,82E-06 3,706E-04 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 2,000 1,82E-06 3,42E-04 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 2,000 3,625E-06 6,326E-04 ! peptide cross-linking GO:0018149 39 19 3,000 3,743E-06 6,097E-04 ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 4,658E-06 7,112E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 5,241E-06 7,531E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 5,869E-06 7,965E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 6,317E-06 8,122E-04 ! axonal fasciculation GO:0007413 19 7 2,000 6,317E-06 7,716E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 6,554E-06 7,624E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 1,003E-05 1,114E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 2,000 1,006E-05 1,069E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 2,000 1,006E-05 1,024E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,006E-05 9,835E-04 ! glycolipid catabolic process GO:0019377 16 8 2,000 1,006E-05 9,457E-04 GO:0046479|glycosphingolipid catabolic process, ! myelination GO:0042552 50 26 3,000 1,399E-05 1,266E-03 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 1,399E-05 1,221E-03 GO:0045936|negative regulation of phosphate metabolic process, ! ganglioside metabolic process GO:0001573 22 9 2,000 1,503E-05 1,266E-03 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 2,000 1,503E-05 1,224E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,503E-05 1,185E-03 ! neuromuscular process controlling posture GO:0050884 15 9 2,000 1,503E-05 1,148E-03 ! negative regulation of protein modification process GO:0031400 66 28 3,000 1,899E-05 1,406E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 4,000 1,903E-05 1,367E-03 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 2,139E-05 1,493E-03 ! ensheathment of neurons GO:0007272 64 31 3,000 2,88E-05 1,954E-03 GO:0008366|axon ensheathment, ! regulation of nitric-oxide synthase activity GO:0050999 28 11 2,000 2,928E-05 1,933E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 2,928E-05 1,882E-03 ! neuroblast proliferation GO:0007405 25 11 2,000 2,928E-05 1,834E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 2,000 2,928E-05 1,788E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 2,928E-05 1,745E-03 GO:0010829|negative regulation of glucose transport, ! spindle organization GO:0007051 50 32 3,000 3,277E-05 1,906E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 3,354E-05 1,906E-03 ! regulation of leukocyte migration GO:0002685 29 12 2,000 3,888E-05 2,159E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 2,000 3,888E-05 2,111E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 4,000 4,831E-05 2,566E-03 ! cellular carbohydrate catabolic process GO:0044275 17 13 2,000 5,033E-05 2,616E-03 ! regulation of monooxygenase activity GO:0032768 35 13 2,000 5,033E-05 2,561E-03 ! regulation of RNA splicing GO:0043484 22 13 2,000 5,033E-05 2,509E-03 ! negative regulation of kinase activity GO:0033673 145 70 4,000 5,179E-05 2,53E-03 ! lipid localization GO:0010876 32 14 2,000 6,378E-05 3,055E-03 GO:0019915|lipid storage, ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 6,378E-05 2,997E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 6,378E-05 2,94E-03 ! negative regulation of transferase activity GO:0051348 155 74 4,000 6,766E-05 3,061E-03 ! regulation of mRNA processing GO:0050684 26 15 2,000 7,939E-05 3,526E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 7,939E-05 3,464E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 7,939E-05 3,403E-03 ! regulation of action potential in neuron GO:0019228 80 40 3,000 8,035E-05 3,384E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 3,000 8,864E-05 3,67E-03 ! fructose metabolic process GO:0006000 25 16 2,000 9,73E-05 3,962E-03 ! neuron recognition GO:0008038 40 16 2,000 9,73E-05 3,897E-03 ! positive regulation of phosphorylation GO:0042327 149 81 4,000 1,042E-04 4,106E-03 ! response to oxygen levels GO:0070482 183 83 4,000 1,17E-04 4,537E-03 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 4,000 1,17E-04 4,466E-03 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of survival gene product expression GO:0045884 38 17 2,000 1,177E-04 4,422E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 1,177E-04 4,355E-03 ! adult walking behavior GO:0007628 36 18 2,000 1,406E-04 5,126E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 1,406E-04 5,051E-03 ! sphingolipid catabolic process GO:0030149 32 18 2,000 1,406E-04 4,978E-03 GO:0046466|membrane lipid catabolic process, ! regulation of endothelial cell migration GO:0010594 45 19 2,000 1,663E-04 5,802E-03 ! regulation of action potential GO:0001508 102 50 3,000 1,937E-04 6,663E-03 ! induction of apoptosis by extracellular signals GO:0008624 99 50 3,000 1,937E-04 6,571E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 1,948E-04 6,518E-03 ! regulation of glucose import GO:0046324 30 20 2,000 1,948E-04 6,43E-03 GO:0010827|regulation of glucose transport, ! negative regulation of translation GO:0017148 32 20 2,000 1,948E-04 6,344E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 2,263E-04 7,274E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 2,263E-04 7,179E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 2,554E-04 7,999E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 2,609E-04 8,068E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 2,609E-04 7,967E-03 ! response to UV GO:0009411 120 55 3,000 2,805E-04 8,459E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 2,988E-04 8,902E-03 ! lysosome organization GO:0007040 47 23 2,000 2,988E-04 8,794E-03 ! acetyl-CoA catabolic process GO:0046356 37 23 2,000 2,988E-04 8,69E-03 GO:0006099|tricarboxylic acid cycle, ! response to superoxide GO:0000303 10 5 1,000 3,209E-04 9,224E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,209E-04 9,117E-03 ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 3,209E-04 9,012E-03 ! apoptotic cell clearance GO:0043277 23 5 1,000 3,209E-04 8,909E-03 ! anagen GO:0042640 7 5 1,000 3,209E-04 8,809E-03 ! skeletal myofibril assembly GO:0014866 12 5 1,000 3,209E-04 8,711E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 3,209E-04 8,616E-03 ! microvillus organization GO:0032528 8 5 1,000 3,209E-04 8,522E-03 GO:0030033|microvillus assembly, ! response to food GO:0032094 6 5 1,000 3,209E-04 8,43E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 3,209E-04 8,341E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 3,209E-04 8,253E-03 ! actin nucleation GO:0045010 11 5 1,000 3,209E-04 8,167E-03 ! cardiac myofibril assembly GO:0055003 11 5 1,000 3,209E-04 8,083E-03 ! positive regulation of blood coagulation GO:0030194 12 5 1,000 3,209E-04 8E-03 ! positive regulation of macrophage activation GO:0043032 12 5 1,000 3,209E-04 7,919E-03 ! negative regulation of fibrinolysis GO:0051918 11 5 1,000 3,209E-04 7,84E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 3,209E-04 7,763E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 3,4E-04 8,144E-03 ! glycosphingolipid metabolic process GO:0006687 44 24 2,000 3,4E-04 8,065E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 3,4E-04 7,987E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 3,4E-04 7,911E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 3,443E-04 7,935E-03 ! vacuole organization GO:0007033 49 25 2,000 3,848E-04 8,785E-03 ! coenzyme catabolic process GO:0009109 42 26 2,000 4,331E-04 9,798E-03 ! negative regulation of cell development GO:0010721 83 26 2,000 4,331E-04 9,708E-03 GO:0050768|negative regulation of neurogenesis, ! alditol metabolic process GO:0019400 44 26 2,000 4,331E-04 9,62E-03 ! response to oxygen radical GO:0000305 11 6 1,000 4,796E-04 0,01055508 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 4,796E-04 0,01046083 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,796E-04 0,01036826 GO:0045686|negative regulation of glial cell differentiation, ! hair follicle maturation GO:0048820 8 6 1,000 4,796E-04 0,01027731 ! oxygen homeostasis GO:0032364 10 6 1,000 4,796E-04 0,01018794 ! negative regulation of axon extension GO:0030517 24 6 1,000 4,796E-04 0,01010012 ! removal of superoxide radicals GO:0019430 12 6 1,000 4,796E-04 0,01001379 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 4,796E-04 9,929E-03 ! positive regulation of coagulation GO:0050820 13 6 1,000 4,796E-04 9,845E-03 ! acetyl-CoA metabolic process GO:0006084 41 27 2,000 4,852E-04 9,879E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 4,852E-04 9,797E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 4,852E-04 9,717E-03 ! integrin-mediated signaling pathway GO:0007229 160 64 3,000 5,02E-04 9,971E-03 ! lymphocyte mediated immunity GO:0002449 122 65 3,000 5,326E-04 0,0104921 ! positive regulation of cell motion GO:0051272 157 65 3,000 5,326E-04 0,01040816 ! dendrite development GO:0016358 67 28 2,000 5,412E-04 0,01049307 ! sperm motility GO:0030317 37 28 2,000 5,412E-04 0,01041045 ! glycolipid metabolic process GO:0006664 50 28 2,000 5,412E-04 0,01032912 ! glutathione metabolic process GO:0006749 42 28 2,000 5,412E-04 0,01024905 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 6,011E-04 0,01129613 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 2,000 6,011E-04 0,0112099 ! neuromuscular process controlling balance GO:0050885 67 29 2,000 6,011E-04 0,01112498 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 2,000 6,651E-04 0,01221673 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 6,68E-04 0,01217908 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 6,689E-04 0,01210434 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 6,689E-04 0,01201534 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 6,689E-04 0,01192763 ! neuron adhesion GO:0007158 14 7 1,000 6,689E-04 0,0118412 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 6,689E-04 0,01175601 ! mRNA stabilization GO:0048255 18 7 1,000 6,689E-04 0,01167204 GO:0043489|RNA stabilization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 6,689E-04 0,01158926 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 1,000 6,689E-04 0,01150765 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 1,000 6,689E-04 0,01142717 ! rRNA modification GO:0000154 14 7 1,000 6,689E-04 0,01134782 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 6,689E-04 0,01126956 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 1,000 6,689E-04 0,01119237 ! negative regulation of focal adhesion formation GO:0051895 21 7 1,000 6,689E-04 0,01111623 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 6,689E-04 0,01104112 ! regulation of lipid transport GO:0032368 14 7 1,000 6,689E-04 0,01096702 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 1,000 6,689E-04 0,01089391 ! iron ion homeostasis GO:0055072 60 31 2,000 7,333E-04 0,01186341 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 7,333E-04 0,01178536 ! cofactor catabolic process GO:0051187 54 31 2,000 7,333E-04 0,01170833 ! response to heat GO:0009408 54 31 2,000 7,333E-04 0,0116323 ! hexose biosynthetic process GO:0019319 53 32 2,000 8,057E-04 0,01269941 ! leukocyte chemotaxis GO:0030595 55 33 2,000 8,826E-04 0,01382167 GO:0060326|cell chemotaxis, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 8,885E-04 0,01382538 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 8,885E-04 0,01373788 ! T-helper 1 type immune response GO:0042088 12 8 1,000 8,885E-04 0,01365148 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 1,000 8,885E-04 0,01356616 ! ER overload response GO:0006983 13 8 1,000 8,885E-04 0,0134819 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 8,885E-04 0,01339868 ! regulation of vascular permeability GO:0043114 12 8 1,000 8,885E-04 0,01331648 ! negative regulation of translational initiation GO:0045947 12 8 1,000 8,885E-04 0,01323528 ! cardiac muscle cell development GO:0055013 14 8 1,000 8,885E-04 0,01315506 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 8,885E-04 0,01307582 ! regulation of focal adhesion formation GO:0051893 23 8 1,000 8,885E-04 0,01299752 ! gas homeostasis GO:0033483 14 8 1,000 8,885E-04 0,01292015 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 1,000 8,885E-04 0,0128437 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 8,885E-04 0,01276815 GO:0002688|regulation of leukocyte chemotaxis, ! negative regulation of organic acid transport GO:0032891 13 8 1,000 8,885E-04 0,01269348 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 1,000 8,885E-04 0,01261968 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 8,885E-04 0,01254674 ! leukocyte mediated immunity GO:0002443 136 75 3,000 9,145E-04 0,0128404 ! axon guidance GO:0007411 162 75 3,000 9,145E-04 0,01276702 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 9,64E-04 0,01338035 ! adult locomotory behavior GO:0008344 62 34 2,000 9,64E-04 0,01330476 ! ceramide metabolic process GO:0006672 72 35 2,000 1,05E-03 0,01440976 ! microtubule bundle formation GO:0001578 22 9 1,000 1,138E-03 0,01553218 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,138E-03 0,01544589 ! regulation of macrophage activation GO:0043030 17 9 1,000 1,138E-03 0,01536055 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,138E-03 0,01527615 ! aerobic respiration GO:0009060 56 36 2,000 1,141E-03 0,01522625 ! monosaccharide biosynthetic process GO:0046364 57 36 2,000 1,141E-03 0,0151435 ! response to hypoxia GO:0001666 178 81 3,000 1,219E-03 0,01609731 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 2,000 1,236E-03 0,01623428 ! actomyosin structure organization GO:0031032 68 37 2,000 1,236E-03 0,01614747 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 1,236E-03 0,01606158 ! regulation of microtubule-based process GO:0032886 86 37 2,000 1,236E-03 0,0159766 ! sphingoid metabolic process GO:0046519 78 38 2,000 1,336E-03 0,01718256 ! glycogen metabolic process GO:0005977 63 38 2,000 1,336E-03 0,01709259 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 1,336E-03 0,01700357 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 1,417E-03 0,01793919 ! negative regulation of blood pressure GO:0045776 26 10 1,000 1,417E-03 0,01784672 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,417E-03 0,0177552 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 1,417E-03 0,01766461 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 1,000 1,417E-03 0,01757494 ! lung alveolus development GO:0048286 26 10 1,000 1,417E-03 0,01748618 ! glucan biosynthetic process GO:0009250 14 10 1,000 1,417E-03 0,01739831 GO:0005978|glycogen biosynthetic process, ! phagocytosis, engulfment GO:0006911 33 10 1,000 1,417E-03 0,01731132 ! motor axon guidance GO:0008045 22 10 1,000 1,417E-03 0,01722519 ! regulation of bone resorption GO:0045124 25 10 1,000 1,417E-03 0,01713992 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,417E-03 0,01705549 GO:0045685|regulation of glial cell differentiation, ! regulation of fibrinolysis GO:0051917 20 10 1,000 1,417E-03 0,01697188 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 1,417E-03 0,01688909 ! glucan metabolic process GO:0044042 64 39 2,000 1,442E-03 0,01709687 GO:0006073|cellular glucan metabolic process, ! negative regulation of transport GO:0051051 164 85 3,000 1,457E-03 0,01720104 ! regulation of neuron differentiation GO:0045664 187 85 3,000 1,457E-03 0,01711834 ! mitochondrion organization GO:0007005 159 87 3,000 1,588E-03 0,0185635 ! cellular respiration GO:0045333 143 88 3,000 1,656E-03 0,01926941 ! mesenchymal cell development GO:0014031 94 41 2,000 1,668E-03 0,01930731 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,726E-03 0,01988566 ! blood vessel remodeling GO:0001974 30 11 1,000 1,726E-03 0,0197923 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,726E-03 0,01969981 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,726E-03 0,01960818 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,726E-03 0,0195174 ! negative regulation of axonogenesis GO:0050771 37 11 1,000 1,726E-03 0,01942746 ! regulation of organic acid transport GO:0032890 19 11 1,000 1,726E-03 0,01933834 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 1,000 1,726E-03 0,01925004 ! alcohol biosynthetic process GO:0046165 65 42 2,000 1,788E-03 0,01985857 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 2,000 1,914E-03 0,02116261 ! regulation of cell morphogenesis GO:0022604 243 93 3,000 2,029E-03 0,02232372 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 2,029E-03 0,02222361 ! response to reactive oxygen species GO:0000302 75 44 2,000 2,046E-03 0,02231336 ! energy reserve metabolic process GO:0006112 76 44 2,000 2,046E-03 0,02221419 ! negative regulation of protein complex disassembly GO:0043242 113 44 2,000 2,046E-03 0,0221159 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,063E-03 0,02220227 ! regulation of B cell proliferation GO:0030888 22 12 1,000 2,063E-03 0,02210489 ! hippocampus development GO:0021766 29 12 1,000 2,063E-03 0,02200837 ! negative regulation of endothelial cell migration GO:0010596 26 12 1,000 2,063E-03 0,02191268 ! regulation of interleukin-12 production GO:0032655 19 12 1,000 2,063E-03 0,02181782 ! histone acetylation GO:0016573 27 12 1,000 2,063E-03 0,02172377 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,063E-03 0,02163054 ! T cell homeostasis GO:0043029 28 12 1,000 2,063E-03 0,0215381 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 2,063E-03 0,02144645 GO:0042130|negative regulation of T cell proliferation, ! localization within membrane GO:0051668 26 12 1,000 2,063E-03 0,02135558 ! carbohydrate biosynthetic process GO:0016051 158 94 3,000 2,109E-03 0,02174387 ! regulation of membrane potential GO:0042391 179 94 3,000 2,109E-03 0,02165251 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 2,183E-03 0,02231319 ! polyol metabolic process GO:0019751 77 45 2,000 2,183E-03 0,02222022 ! leukocyte migration GO:0050900 75 46 2,000 2,325E-03 0,02357304 ! negative regulation of cell migration GO:0030336 122 46 2,000 2,325E-03 0,02347563 ! negative regulation of cell projection organization GO:0031345 42 13 1,000 2,429E-03 0,02441938 ! Golgi organization GO:0007030 25 13 1,000 2,429E-03 0,0243193 ! regulation of mRNA stability GO:0043488 32 13 1,000 2,429E-03 0,02422004 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 1,000 2,429E-03 0,02412158 ! response to insulin stimulus GO:0032868 98 47 2,000 2,474E-03 0,02446613 ! positive regulation of cell cycle GO:0045787 96 48 2,000 2,628E-03 0,02588356 ! positive regulation of defense response GO:0031349 88 48 2,000 2,628E-03 0,02577961 ! vascular process in circulatory system GO:0003018 85 48 2,000 2,628E-03 0,02567649 ! regulation of inflammatory response GO:0050727 84 48 2,000 2,628E-03 0,02557419 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 2,787E-03 0,02702083 ! regulated secretory pathway GO:0045055 24 14 1,000 2,823E-03 0,02726057 ! response to gamma radiation GO:0010332 30 14 1,000 2,823E-03 0,02715325 ! regulation of RNA stability GO:0043487 33 14 1,000 2,823E-03 0,02704676 ! regulation of axon extension GO:0030516 43 14 1,000 2,823E-03 0,02694111 ! peptide metabolic process GO:0006518 80 51 2,000 3,124E-03 0,02969882 ! response to temperature stimulus GO:0009266 84 51 2,000 3,124E-03 0,02958371 ! negative regulation of immune system process GO:0002683 101 51 2,000 3,124E-03 0,02946949 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 3,245E-03 0,03049289 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,245E-03 0,03037605 ! sulfate transport GO:0008272 27 15 1,000 3,245E-03 0,03026012 ! response to hexose stimulus GO:0009746 25 15 1,000 3,245E-03 0,03014506 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! intermediate filament cytoskeleton organization GO:0045104 34 15 1,000 3,245E-03 0,03003087 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 3,245E-03 0,02991755 ! lymphocyte homeostasis GO:0002260 33 15 1,000 3,245E-03 0,02980508 ! regulation of protein complex disassembly GO:0043244 127 52 2,000 3,302E-03 0,0302103 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 3,485E-03 0,03177055 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 2,000 3,485E-03 0,03165244 ! cartilage development GO:0051216 99 53 2,000 3,485E-03 0,03153521 ! regulation of angiogenesis GO:0045765 125 54 2,000 3,675E-03 0,03312849 ! neuromuscular process GO:0050905 107 54 2,000 3,675E-03 0,03300669 ! regulation of muscle contraction GO:0006937 94 54 2,000 3,675E-03 0,03288579 ! regulation of cell shape GO:0008360 142 54 2,000 3,675E-03 0,03276577 ! heterophilic cell adhesion GO:0007157 43 16 1,000 3,695E-03 0,03282467 ! intermediate filament-based process GO:0045103 36 16 1,000 3,695E-03 0,03270574 ! axon cargo transport GO:0008088 46 16 1,000 3,695E-03 0,03258767 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,695E-03 0,03247045 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 3,695E-03 0,03235407 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,695E-03 0,03223851 ! cell recognition GO:0008037 98 55 2,000 3,871E-03 0,0336521 ! negative regulation of cell motion GO:0051271 142 55 2,000 3,871E-03 0,03353277 ! negative regulation of cytoskeleton organization GO:0051494 139 56 2,000 4,073E-03 0,03515872 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 4,172E-03 0,03588743 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 4,172E-03 0,03576151 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 4,172E-03 0,03563647 GO:0031114|regulation of microtubule depolymerization, ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 4,172E-03 0,0355123 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 4,172E-03 0,03538899 ! cellular polysaccharide metabolic process GO:0044264 93 58 2,000 4,496E-03 0,03800557 ! limbic system development GO:0021761 40 18 1,000 4,676E-03 0,03939 ! patterning of blood vessels GO:0001569 43 18 1,000 4,676E-03 0,03925464 ! positive regulation of proteolysis GO:0045862 36 18 1,000 4,676E-03 0,03912021 ! cell-substrate junction assembly GO:0007044 56 18 1,000 4,676E-03 0,03898669 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 4,676E-03 0,03885408 ! adult behavior GO:0030534 104 60 2,000 4,945E-03 0,04094912 ! glycosaminoglycan metabolic process GO:0030203 108 61 2,000 5,179E-03 0,0427433 ! regulation of heart contraction GO:0008016 123 61 2,000 5,179E-03 0,04259939 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 5,179E-03 0,04245644 ! positive regulation of translation GO:0045727 31 19 1,000 5,206E-03 0,04253917 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 5,206E-03 0,04239737 ! memory GO:0007613 34 19 1,000 5,206E-03 0,04225651 ! neuromuscular junction development GO:0007528 43 19 1,000 5,206E-03 0,04211659 ! heart process GO:0003015 32 19 1,000 5,206E-03 0,04197759 GO:0060047|heart contraction, ! regulation of homeostatic process GO:0032844 148 62 2,000 5,42E-03 0,04355297 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 5,763E-03 0,04616258 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 5,763E-03 0,04601172 ! protein amino acid acetylation GO:0006473 41 20 1,000 5,763E-03 0,04586185 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 5,763E-03 0,04571294 ! response to alkaloid GO:0043279 38 20 1,000 5,763E-03 0,04556501 ! response to carbohydrate stimulus GO:0009743 33 20 1,000 5,763E-03 0,04541802 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 5,763E-03 0,04527198 ! negative regulation of T cell activation GO:0050868 41 20 1,000 5,763E-03 0,04512688 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 5,921E-03 0,0462138 ! sphingolipid metabolic process GO:0006665 122 65 2,000 6,182E-03 0,04809517 ! lipid phosphorylation GO:0046834 43 21 1,000 6,346E-03 0,04921733 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 6,346E-03 0,04906158 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 6,346E-03 0,04890681 ! leukotriene biosynthetic process GO:0019370 42 21 1,000 6,346E-03 0,04875302 GO:0043450|alkene biosynthetic process, ! actin filament-based movement GO:0030048 47 21 1,000 6,346E-03 0,04860018 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 6,449E-03 0,04923551 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 6,955E-03 0,05292855 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 1,000 6,955E-03 0,05276418 ! microtubule-based transport GO:0010970 59 22 1,000 6,955E-03 0,05260082 ! glutamate signaling pathway GO:0007215 48 22 1,000 6,955E-03 0,05243847 ! apoptotic nuclear changes GO:0030262 34 22 1,000 6,955E-03 0,05227712 ! vasodilation GO:0042311 40 22 1,000 6,955E-03 0,05211677 ! detection of chemical stimulus GO:0009593 42 22 1,000 6,955E-03 0,05195739 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 6,955E-03 0,05179898 ! positive regulation of B cell activation GO:0050871 42 22 1,000 6,955E-03 0,05164154 ! negative regulation of cell size GO:0045792 144 69 2,000 7,293E-03 0,0539877 ! lung development GO:0030324 165 69 2,000 7,293E-03 0,05382459 ! cell redox homeostasis GO:0045454 114 70 2,000 7,588E-03 0,05583286 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 7,588E-03 0,05567162 GO:0010810|regulation of cell-substrate adhesion, ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 7,588E-03 0,05550494 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 1,000 7,588E-03 0,05533925 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 7,588E-03 0,05517455 ! negative regulation of cytokine production GO:0001818 41 23 1,000 7,588E-03 0,05501083 ! aminoglycan metabolic process GO:0006022 121 71 2,000 7,89E-03 0,05702393 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 7,89E-03 0,05685572 ! respiratory tube development GO:0030323 171 72 2,000 8,198E-03 0,05890814 ! actin filament organization GO:0007015 167 72 2,000 8,198E-03 0,05873539 ! membrane lipid metabolic process GO:0006643 132 72 2,000 8,198E-03 0,05856365 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 8,247E-03 0,05874188 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 8,247E-03 0,05857112 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 8,247E-03 0,05840134 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 8,247E-03 0,05823255 ! barbed-end actin filament capping GO:0051016 58 24 1,000 8,247E-03 0,05806474 GO:0051693|actin filament capping, ! leukotriene metabolic process GO:0006691 47 24 1,000 8,247E-03 0,05789788 ! pallium development GO:0021543 56 24 1,000 8,247E-03 0,05773199 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 8,837E-03 0,06168505 ! respiratory system development GO:0060541 175 74 2,000 8,837E-03 0,06150931 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 8,931E-03 0,06198512 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 8,931E-03 0,06180953 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 8,931E-03 0,06163493 ! leukocyte adhesion GO:0007159 55 25 1,000 8,931E-03 0,06146131 ! vasculogenesis GO:0001570 49 25 1,000 8,931E-03 0,06128866 ! leukocyte homeostasis GO:0001776 50 25 1,000 8,931E-03 0,06111699 ! cellular alkene metabolic process GO:0043449 48 25 1,000 8,931E-03 0,06094627 ! molting cycle process GO:0022404 52 26 1,000 9,639E-03 0,06559558 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 9,639E-03 0,06541337 ! regulation of blood coagulation GO:0030193 46 26 1,000 9,639E-03 0,06523217 ! negative regulation of actin filament depolymerization GO:0030835 63 27 1,000 0,01037163 0,06999415 ! negative regulation of actin filament polymerization GO:0030837 61 27 1,000 0,01037163 0,06980133 ! iron ion transport GO:0006826 65 27 1,000 0,01037163 0,06960957 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 1,000 0,01037163 0,06941886 ! superoxide metabolic process GO:0006801 41 27 1,000 0,01037163 0,06922919 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01037163 0,06904055 ! regulation of chromosome organization GO:0033044 49 27 1,000 0,01037163 0,06885294 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 0,01037163 0,06866635 ! activation of protein kinase activity GO:0032147 170 80 2,000 0,01092567 0,07213896 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01092567 0,07194451 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 0,01112781 0,07307863 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 0,01112781 0,07288271 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01112781 0,07268783 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 0,01112781 0,072494 ! negative regulation of protein polymerization GO:0032272 63 28 1,000 0,01112781 0,0723012 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01190757 0,07716232 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01190757 0,07695819 ! somitogenesis GO:0001756 52 29 1,000 0,01190757 0,07675513 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01190757 0,07655314 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01190757 0,07635222 ! exocytosis GO:0006887 153 83 2,000 0,01206757 0,0771756 ! cellular lipid catabolic process GO:0044242 150 83 2,000 0,01206757 0,0769741 ! regulation of actin filament depolymerization GO:0030834 67 30 1,000 0,0127106 0,0808646 ! negative regulation of protein complex assembly GO:0031333 68 30 1,000 0,0127106 0,08065456 ! icosanoid biosynthetic process GO:0046456 60 30 1,000 0,0127106 0,08044561 ! acute-phase response GO:0006953 50 30 1,000 0,0127106 0,08023774 ! myofibril assembly GO:0030239 50 30 1,000 0,0127106 0,08003094 GO:0055002|striated muscle cell development, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,0127106 0,07982521 ! regulation of B cell activation GO:0050864 55 30 1,000 0,0127106 0,07962053 ! regulation of coagulation GO:0050818 52 30 1,000 0,0127106 0,0794169 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 0,01286549 0,08017955 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,0132755 0,08252429 GO:0002696|positive regulation of leukocyte activation, ! cell junction assembly GO:0034329 85 31 1,000 0,01353663 0,08393396 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,01353663 0,08372147 ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 0,01353663 0,08351005 ! alcohol catabolic process GO:0046164 142 87 2,000 0,01369291 0,08426138 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 1,000 0,01438535 0,08830005 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01438535 0,08807874 ! muscle cell development GO:0055001 52 32 1,000 0,01438535 0,08785855 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01438535 0,08763945 ! BMP signaling pathway GO:0030509 71 32 1,000 0,01438535 0,08742144 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01438535 0,08720451 ! positive regulation of protein modification process GO:0031401 156 90 2,000 0,01498966 0,0906429 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 1,000 0,0152565 0,09202871 ! response to ionizing radiation GO:0010212 74 33 1,000 0,0152565 0,09180204 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,0152565 0,09157648 ! ossification GO:0001503 205 91 2,000 0,0154368 0,09243163 ! bone development GO:0060348 206 92 2,000 0,01589141 0,09492109 ! regulation of cell adhesion GO:0030155 241 92 2,000 0,01589141 0,09468957 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01614978 0,09599494 ! post-embryonic development GO:0009791 76 34 1,000 0,01614978 0,09576194 ! telencephalon development GO:0021537 81 35 1,000 0,01706493 0,10094338 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01706493 0,10069956 ! placenta development GO:0001890 53 35 1,000 0,01706493 0,10045691 ! regulation of defense response GO:0031347 171 95 2,000 0,01730018 0,10159697 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,01730018 0,10135333 ! regulation of proteolysis GO:0030162 77 36 1,000 0,01800165 0,10521062 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01895969 0,1105454 ! cell junction organization GO:0034330 96 37 1,000 0,01895969 0,1102822 ! tissue remodeling GO:0048771 78 37 1,000 0,01895969 0,11002025 ! negative regulation of cell activation GO:0050866 69 37 1,000 0,01895969 0,10975954 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01979842 0,11434404 GO:0060538|skeletal muscle organ development, ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 0,01993877 0,11488303 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,02093861 0,12036006 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02093861 0,12007752 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,02093861 0,11979631 ! mammary gland development GO:0030879 93 40 1,000 0,02195896 0,12534049 ! nucleus organization GO:0006997 73 40 1,000 0,02195896 0,12504832 ! RNA modification GO:0009451 64 41 1,000 0,02299954 0,13066948 ! ear morphogenesis GO:0042471 64 42 1,000 0,0240601 0,13637779 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,0240601 0,1360621 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,0240601 0,13574787 ! cytokinesis GO:0000910 84 42 1,000 0,0240601 0,13543509 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02514038 0,14119068 GO:0090047|positive regulation of transcription regulator activity, ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 1,000 0,02514038 0,14086684 ! regulation of tube size GO:0035150 76 43 1,000 0,02514038 0,14054449 GO:0050880|regulation of blood vessel size, ! glucose transport GO:0015758 66 43 1,000 0,02514038 0,14022362 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,02514038 0,1399042 ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,02514038 0,13958624 ! segmentation GO:0035282 78 43 1,000 0,02514038 0,13926971 ! neuron migration GO:0001764 85 43 1,000 0,02514038 0,13895462 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,02514038 0,13864096 ! hexose transport GO:0008645 68 44 1,000 0,02624011 0,14437973 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,02624011 0,14405528 ! phagocytosis GO:0006909 105 44 1,000 0,02624011 0,14373228 ! heterocycle biosynthetic process GO:0018130 76 44 1,000 0,02624011 0,14341074 ! double-strand break repair GO:0006302 85 44 1,000 0,02624011 0,14309062 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,02735905 0,14886006 ! keratinocyte differentiation GO:0030216 81 45 1,000 0,02735905 0,14852926 ! developmental growth GO:0048589 88 45 1,000 0,02735905 0,14819993 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,0282334 0,15259779 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,0282334 0,15226093 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,0282334 0,15192555 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,0282334 0,15159165 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,0282334 0,15125921 ! neuron fate determination GO:0048664 7 5 0,000 0,0282334 0,15092823 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0282334 0,15059869 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,0282334 0,15027059 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,0282334 0,14994392 ! polyol transport GO:0015791 12 5 0,000 0,0282334 0,14961866 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,0282334 0,14929481 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,0282334 0,14897236 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,0282334 0,1486513 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,0282334 0,14833162 ! female meiosis GO:0007143 10 5 0,000 0,0282334 0,14801331 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,0282334 0,14769636 ! hypothalamus development GO:0021854 9 5 0,000 0,0282334 0,14738077 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,0282334 0,14706653 ! cobalt ion transport GO:0006824 11 5 0,000 0,0282334 0,14675362 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,0282334 0,14644204 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,0282334 0,14613178 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,0282334 0,14582284 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,0282334 0,14551519 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,0282334 0,14520885 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,0282334 0,14490379 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,0282334 0,1446 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0282334 0,14429749 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,0282334 0,14399625 ! transposition GO:0032196 9 5 0,000 0,0282334 0,14369625 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,0282334 0,14339751 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,0282334 0,1431 ! negative chemotaxis GO:0050919 16 5 0,000 0,0282334 0,14280373 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,0282334 0,14250868 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,0282334 0,14221485 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,0282334 0,14192223 ! behavioral response to pain GO:0048266 10 5 0,000 0,0282334 0,1416308 ! clathrin coat assembly GO:0048268 15 5 0,000 0,0282334 0,14134058 ! Notch receptor processing GO:0007220 11 5 0,000 0,0282334 0,14105154 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0282334 0,14076368 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,0282334 0,14047699 ! micturition GO:0060073 9 5 0,000 0,0282334 0,14019147 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,0282334 0,1399071 ! copulation GO:0007620 9 5 0,000 0,0282334 0,13962389 ! glial cell fate commitment GO:0021781 14 5 0,000 0,0282334 0,13934182 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,0282334 0,13906089 ! bioluminescence GO:0008218 9 5 0,000 0,0282334 0,13878109 ! spermidine metabolic process GO:0008216 7 5 0,000 0,0282334 0,13850241 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,0282334 0,13822485 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,0282334 0,1379484 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,0282334 0,13767306 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,0282334 0,13739881 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,0282334 0,13712565 ! grooming behavior GO:0007625 6 5 0,000 0,0282334 0,13685357 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,0282334 0,13658258 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,0282334 0,13631265 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,0282334 0,13604379 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0282334 0,13577599 ! response to protozoan GO:0001562 13 5 0,000 0,0282334 0,13550924 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,0282334 0,13524353 ! lymph vessel development GO:0001945 10 5 0,000 0,0282334 0,13497887 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,0282334 0,13471524 ! endochondral ossification GO:0001958 17 5 0,000 0,0282334 0,13445263 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,0282334 0,13419105 ! single strand break repair GO:0000012 8 5 0,000 0,0282334 0,13393049 ! parathyroid gland development GO:0060017 14 5 0,000 0,0282334 0,13367093 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,0282334 0,13341238 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,0282334 0,13315483 ! cytokine secretion GO:0050663 15 5 0,000 0,0282334 0,13289827 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,0282334 0,1326427 ! ceramide catabolic process GO:0046514 7 5 0,000 0,0282334 0,1323881 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,0282334 0,13213449 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,0282334 0,13188184 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,0282334 0,13163016 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,0282334 0,13137943 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,0282334 0,13112966 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,0282334 0,13088084 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,0282334 0,13063296 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,0282334 0,13038601 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,0282334 0,13014 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,0282334 0,12989492 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,0282334 0,12965076 ! valine metabolic process GO:0006573 12 5 0,000 0,0282334 0,12940751 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,0282334 0,12916517 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,0282334 0,12892374 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,0282334 0,12868321 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,0282334 0,12844358 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,0282334 0,12820484 ! polyol biosynthetic process GO:0046173 6 5 0,000 0,0282334 0,12796698 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,0282334 0,12773 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,0282334 0,1274939 ! muscle cell migration GO:0014812 8 5 0,000 0,0282334 0,12725867 ! mitochondrial fission GO:0000266 8 5 0,000 0,0282334 0,12702431 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,0282334 0,12679081 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,0282334 0,12655817 ! mRNA transcription GO:0009299 10 5 0,000 0,0282334 0,12632638 ! nerve growth factor processing GO:0032455 9 5 0,000 0,0282334 0,12609543 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,0282334 0,12586533 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,0282334 0,12563607 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,0282334 0,12540764 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,0282334 0,12518004 ! monocyte activation GO:0042117 10 5 0,000 0,0282334 0,12495326 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,0282334 0,12472731 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,0282334 0,12450217 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,0282334 0,12427784 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,0282334 0,12405432 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,0282334 0,1238316 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0282334 0,12360968 ! forebrain neuron development GO:0021884 13 5 0,000 0,0282334 0,12338855 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,0282334 0,12316822 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,0282334 0,12294867 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,0282334 0,1227299 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0282334 0,1225119 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,0282334 0,12229468 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,0282334 0,12207823 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,0282334 0,12186255 ! lipid glycosylation GO:0030259 7 5 0,000 0,0282334 0,12164762 ! nucleobase transport GO:0015851 6 5 0,000 0,0282334 0,12143345 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0282334 0,12122004 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,0282334 0,12100737 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,0282334 0,12079545 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,0282334 0,12058427 ! basic amino acid transport GO:0015802 12 5 0,000 0,0282334 0,12037383 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,0282334 0,12016411 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,0282334 0,11995513 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0282334 0,11974688 ! depurination GO:0045007 5 5 0,000 0,0282334 0,11953934 ! depyrimidination GO:0045008 10 5 0,000 0,0282334 0,11933253 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,0282334 0,11912643 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0282334 0,11892104 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,0282334 0,11871635 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,0282334 0,11851237 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,0282334 0,11830909 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,0282334 0,11810651 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,0282334 0,11790462 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0282334 0,11770342 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,0282334 0,1175029 ! activated T cell proliferation GO:0050798 16 5 0,000 0,0282334 0,11730306 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,0282334 0,11710391 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,0282334 0,11690543 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0282334 0,11670762 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,0282334 0,11651048 ! response to arsenic GO:0046685 11 5 0,000 0,0282334 0,116314 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,0282334 0,11611818 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,0282334 0,11592303 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,0282334 0,11572853 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,0282334 0,11553468 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,0282334 0,11534147 ! response to mercury ion GO:0046689 8 5 0,000 0,0282334 0,11514892 ! response to cadmium ion GO:0046686 7 5 0,000 0,0282334 0,114957 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,0282334 0,11476573 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,0282334 0,11457509 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,0282334 0,11438508 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,0282334 0,1141957 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,0282334 0,11400695 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,0282334 0,11381881 ! decidualization GO:0046697 11 5 0,000 0,0282334 0,1136313 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,0282334 0,11344441 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,0282334 0,11325813 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,0282334 0,11307246 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,0282334 0,1128874 ! embryonic cleavage GO:0040016 6 5 0,000 0,0282334 0,11270294 ! peroxisome fission GO:0016559 5 5 0,000 0,0282334 0,11251909 ! histone demethylation GO:0016577 13 5 0,000 0,0282334 0,11233583 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,0282334 0,11215317 ! mitotic recombination GO:0006312 9 5 0,000 0,0282334 0,11197111 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,0282334 0,11178963 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,0282334 0,11160874 ! metaphase plate congression GO:0051310 7 5 0,000 0,0282334 0,11142844 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0282334 0,11124871 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,0282334 0,11106957 ! enteric nervous system development GO:0048484 8 5 0,000 0,0282334 0,110891 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,0282334 0,110713 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,0282334 0,11053558 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,0282334 0,11035872 ! muscle cell proliferation GO:0033002 12 5 0,000 0,0282334 0,11018243 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,0282334 0,1100067 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,0282334 0,10983153 ! B cell homeostasis GO:0001782 13 5 0,000 0,0282334 0,10965692 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,0282334 0,10948286 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,0282334 0,10930935 ! metaphase GO:0051323 11 5 0,000 0,0282334 0,1091364 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,0282334 0,10896398 GO:0030186|melatonin metabolic process, ! cellular response to nutrient GO:0031670 8 5 0,000 0,0282334 0,10879212 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,0282334 0,10862079 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,0282334 0,10845 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,0282334 0,10827975 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,0282334 0,10811003 ! response to redox state GO:0051775 6 5 0,000 0,0282334 0,10794085 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,0282334 0,10777219 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,0282334 0,10760406 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,0282334 0,10743645 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,0282334 0,10726937 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,0282334 0,1071028 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0282334 0,10693675 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,0282334 0,10677121 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0282334 0,10660619 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,0282334 0,10644167 ! striatum development GO:0021756 14 5 0,000 0,0282334 0,10627766 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,0282334 0,10611416 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,0282334 0,10595115 ! glial cell migration GO:0008347 10 5 0,000 0,0282334 0,10578865 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,0282334 0,10562665 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,0282334 0,10546514 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,0282334 0,10530412 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,0282334 0,1051436 ! T cell activation during immune response GO:0002286 9 5 0,000 0,0282334 0,10498356 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,0282334 0,10482401 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,0282334 0,10466495 ! neuroprotection GO:0043526 8 5 0,000 0,0282334 0,10450637 ! regulation of sensory perception GO:0051931 8 5 0,000 0,0282334 0,10434826 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,0282334 0,10419064 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,0282334 0,10403349 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,0282334 0,10387681 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,0282334 0,1037206 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,0282334 0,10356487 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,0282334 0,1034096 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,0282334 0,10325479 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,0282334 0,10310045 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,0282334 0,10294657 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,0282334 0,10279315 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,0282334 0,10264018 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,0282334 0,10248767 ! protein palmitoylation GO:0018345 12 5 0,000 0,0282334 0,10233561 ! drug metabolic process GO:0017144 7 5 0,000 0,0282334 0,102184 ! stem cell division GO:0017145 11 5 0,000 0,0282334 0,10203284 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,0282334 0,10188213 ! organ regeneration GO:0031100 7 5 0,000 0,0282334 0,10173186 ! carnitine metabolic process GO:0009437 8 5 0,000 0,0282334 0,10158203 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,0282334 0,10143265 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,02849694 0,10222913 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,02849694 0,10207923 ! polysaccharide biosynthetic process GO:0000271 79 46 1,000 0,02849694 0,10192977 ! pigmentation GO:0043473 103 46 1,000 0,02849694 0,10178075 ! cell growth GO:0016049 90 46 1,000 0,02849694 0,10163217 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,02849694 0,10148402 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,02965354 0,10544918 ! cellular component disassembly GO:0022411 89 48 1,000 0,03082858 0,10946834 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,03082858 0,10930946 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03082858 0,10915104 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,03082858 0,10899308 ! response to calcium ion GO:0051592 94 49 1,000 0,03202183 0,11304815 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,03202183 0,11288502 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,03202183 0,11272236 ! activation of caspase activity GO:0006919 95 50 1,000 0,03323304 0,11681771 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,03323304 0,11664986 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,03323304 0,1164825 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03378417 0,11824458 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03378417 0,11807542 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03378417 0,11790674 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03378417 0,11773854 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03378417 0,11757083 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03378417 0,11740358 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03378417 0,11723682 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03378417 0,11707052 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03378417 0,1169047 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03378417 0,11673935 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03378417 0,11657446 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03378417 0,11641004 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03378417 0,11624608 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03378417 0,11608259 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03378417 0,11591955 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03378417 0,11575697 ! forebrain regionalization GO:0021871 9 6 0,000 0,03378417 0,11559485 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03378417 0,11543317 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03378417 0,11527195 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03378417 0,11511118 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03378417 0,11495086 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03378417 0,11479099 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03378417 0,11463155 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03378417 0,11447257 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03378417 0,11431402 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03378417 0,11415591 ! malate metabolic process GO:0006108 13 6 0,000 0,03378417 0,11399823 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03378417 0,11384099 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03378417 0,11368419 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03378417 0,11352781 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03378417 0,11337187 ! protein refolding GO:0042026 15 6 0,000 0,03378417 0,11321635 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03378417 0,11306126 ! opsonization GO:0008228 8 6 0,000 0,03378417 0,11290659 ! mating behavior GO:0007617 7 6 0,000 0,03378417 0,11275235 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03378417 0,11259853 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,03378417 0,11244512 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03378417 0,11229214 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03378417 0,11213956 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03378417 0,11198741 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03378417 0,11183566 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03378417 0,11168433 ! toxin metabolic process GO:0009404 11 6 0,000 0,03378417 0,1115334 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03378417 0,11138289 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03378417 0,11123278 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03378417 0,11108307 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03378417 0,11093376 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03378417 0,11078486 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03378417 0,11063635 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03378417 0,11048825 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03378417 0,11034053 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03378417 0,11019322 ! thymic T cell selection GO:0045061 16 6 0,000 0,03378417 0,11004629 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03378417 0,10989976 ! protein lipoylation GO:0009249 10 6 0,000 0,03378417 0,10975362 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03378417 0,10960786 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03378417 0,10946249 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03378417 0,10931751 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03378417 0,10917291 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03378417 0,10902869 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03378417 0,10888485 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03378417 0,1087414 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03378417 0,10859831 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03378417 0,10845561 ! hyperosmotic response GO:0006972 10 6 0,000 0,03378417 0,10831328 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03378417 0,10817132 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03378417 0,10802974 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03378417 0,10788852 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03378417 0,10774768 ! urea metabolic process GO:0019627 7 6 0,000 0,03378417 0,1076072 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03378417 0,10746708 ! neutrophil activation GO:0042119 7 6 0,000 0,03378417 0,10732733 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03378417 0,10718795 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03378417 0,10704892 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03378417 0,10691026 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03378417 0,10677195 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03378417 0,106634 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03378417 0,10649641 ! neuron apoptosis GO:0051402 15 6 0,000 0,03378417 0,10635917 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03378417 0,10622229 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03378417 0,10608576 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03378417 0,10594958 ! carnitine transport GO:0015879 10 6 0,000 0,03378417 0,10581374 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03378417 0,10567826 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03378417 0,10554312 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03378417 0,10540833 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03378417 0,10527388 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03378417 0,10513977 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03378417 0,105006 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03378417 0,10487258 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03378417 0,10473949 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03378417 0,10460674 ! establishment of spindle localization GO:0051293 16 6 0,000 0,03378417 0,10447433 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03378417 0,10434225 ! neural nucleus development GO:0048857 19 6 0,000 0,03378417 0,1042105 ! response to UV-C GO:0010225 14 6 0,000 0,03378417 0,10407909 ! astrocyte development GO:0014002 16 6 0,000 0,03378417 0,10394801 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03378417 0,10381726 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03378417 0,10368683 ! interaction with symbiont GO:0051702 14 6 0,000 0,03378417 0,10355674 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03378417 0,10342697 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03378417 0,10329752 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03378417 0,1031684 ! response to copper ion GO:0046688 10 6 0,000 0,03378417 0,1030396 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03378417 0,10291112 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03378417 0,10278296 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03378417 0,10265512 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03378417 0,1025276 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03378417 0,1024004 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03378417 0,10227351 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03378417 0,10214693 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03378417 0,10202067 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03378417 0,10189472 ! Schwann cell development GO:0014044 15 6 0,000 0,03378417 0,10176907 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03378417 0,10164374 ! response to pheromone GO:0019236 6 6 0,000 0,03378417 0,10151872 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03378417 0,101394 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03378417 0,10126959 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,03378417 0,10114549 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03378417 0,10102169 ! subpallium development GO:0021544 15 6 0,000 0,03378417 0,10089819 ! neural tube patterning GO:0021532 8 6 0,000 0,03378417 0,10077499 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03378417 0,1006521 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03378417 0,1005295 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03378417 0,1004072 ! G2 phase GO:0051319 16 6 0,000 0,03378417 0,1002852 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03378417 0,10016349 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03378417 0,10004208 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03378417 0,09992097 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03378417 0,09980014 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03378417 0,09967961 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03378417 0,09955937 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03378417 0,09943942 ! receptor internalization GO:0031623 11 6 0,000 0,03378417 0,09931976 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03378417 0,09920038 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03378417 0,0990813 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03378417 0,09896249 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03378417 0,09884398 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03378417 0,09872574 ! protein deubiquitination GO:0016579 16 6 0,000 0,03378417 0,09860779 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03378417 0,09849012 ! protein destabilization GO:0031648 9 6 0,000 0,03378417 0,09837273 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03378417 0,09825562 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03378417 0,09813879 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03378417 0,09802223 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03378417 0,09790595 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03378417 0,09778995 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03378417 0,09767422 GO:0032862|activation of Rho GTPase activity, ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03378417 0,09755877 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03378417 0,09744359 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03378417 0,09732868 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03378417 0,09721404 ! neural plate development GO:0001840 9 6 0,000 0,03378417 0,09709967 ! catecholamine transport GO:0051937 9 6 0,000 0,03378417 0,09698557 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03378417 0,09687174 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03378417 0,09675817 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03378417 0,09664487 ! maternal placenta development GO:0001893 12 6 0,000 0,03378417 0,09653184 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03378417 0,09641906 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03378417 0,09630656 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,03378417 0,09619431 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03378417 0,09608233 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03378417 0,0959706 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03378417 0,09585914 GO:0055081|anion homeostasis, ! regulation of cell projection organization GO:0031344 135 51 1,000 0,03446196 0,09766889 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,03446196 0,09755571 ! positive regulation of binding GO:0051099 88 52 1,000 0,03570837 0,10096708 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,03570837 0,10085035 ! histone modification GO:0016570 104 52 1,000 0,03570837 0,1007339 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,03570837 0,10061771 ! amino acid activation GO:0043038 98 52 1,000 0,03570837 0,10050179 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 1,000 0,03697202 0,10393861 ! positive regulation of growth GO:0045927 96 53 1,000 0,03697202 0,10381914 ! synapse organization GO:0050808 102 53 1,000 0,03697202 0,10369995 ! regulation of translational initiation GO:0006446 87 54 1,000 0,03825268 0,10716893 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,03825268 0,10704617 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 0,03825268 0,10692369 ! tRNA transcription GO:0009304 17 7 0,000 0,03930338 0,10973504 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03930338 0,10960977 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03930338 0,10948479 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03930338 0,10936009 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03930338 0,10923567 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03930338 0,10911154 ! sleep GO:0030431 16 7 0,000 0,03930338 0,10898769 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03930338 0,10886413 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03930338 0,10874084 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03930338 0,10861783 ! prostate gland development GO:0030850 14 7 0,000 0,03930338 0,10849509 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03930338 0,10837264 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03930338 0,10825046 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03930338 0,10812856 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03930338 0,10800693 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03930338 0,10788557 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03930338 0,10776449 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03930338 0,10764368 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03930338 0,10752313 ! glycolipid transport GO:0046836 11 7 0,000 0,03930338 0,10740286 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03930338 0,10728286 GO:0051923|sulfation, ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03930338 0,10716312 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03930338 0,10704365 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03930338 0,10692445 ! pericardium development GO:0060039 16 7 0,000 0,03930338 0,10680552 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03930338 0,10668684 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03930338 0,10656843 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03930338 0,10645029 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03930338 0,1063324 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03930338 0,10621478 ! lipoprotein transport GO:0042953 14 7 0,000 0,03930338 0,10609741 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03930338 0,10598031 ! rhythmic behavior GO:0007622 17 7 0,000 0,03930338 0,10586346 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03930338 0,10574687 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03930338 0,10563054 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03930338 0,10551446 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03930338 0,10539864 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03930338 0,10528307 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03930338 0,10516775 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03930338 0,10505269 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03930338 0,10493788 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03930338 0,10482332 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03930338 0,10470901 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03930338 0,10459494 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03930338 0,10448113 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03930338 0,10436756 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03930338 0,10425424 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03930338 0,10414117 ! spinal cord patterning GO:0021511 14 7 0,000 0,03930338 0,10402834 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03930338 0,10391576 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03930338 0,10380341 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03930338 0,10369132 ! adrenal gland development GO:0030325 17 7 0,000 0,03930338 0,10357946 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03930338 0,10346784 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03930338 0,10335647 ! ovulation GO:0030728 10 7 0,000 0,03930338 0,10324533 ! adenohypophysis development GO:0021984 11 7 0,000 0,03930338 0,10313443 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03930338 0,10302378 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03930338 0,10291335 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! microtubule nucleation GO:0007020 21 7 0,000 0,03930338 0,10280317 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03930338 0,10269322 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03930338 0,1025835 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03930338 0,10247402 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03930338 0,10236477 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03930338 0,10225576 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03930338 0,10214698 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03930338 0,10203843 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03930338 0,1019301 ! galactose metabolic process GO:0006012 13 7 0,000 0,03930338 0,10182201 ! vesicle fusion GO:0006906 20 7 0,000 0,03930338 0,10171415 ! response to dietary excess GO:0002021 8 7 0,000 0,03930338 0,10160652 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03930338 0,10149911 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03930338 0,10139193 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03930338 0,10128498 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03930338 0,10117825 ! organ growth GO:0035265 15 7 0,000 0,03930338 0,10107175 ! nucleoside transport GO:0015858 11 7 0,000 0,03930338 0,10096547 ! nucleoside salvage GO:0043174 11 7 0,000 0,03930338 0,10085941 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03930338 0,10075358 ! male sex determination GO:0030238 15 7 0,000 0,03930338 0,10064796 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03930338 0,10054257 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03930338 0,1004374 ! parturition GO:0007567 16 7 0,000 0,03930338 0,10033245 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03930338 0,10022772 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03930338 0,10012321 ! spindle checkpoint GO:0031577 16 7 0,000 0,03930338 0,10001891 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03930338 0,09991484 ! monocyte differentiation GO:0030224 16 7 0,000 0,03930338 0,09981098 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03930338 0,09970733 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03930338 0,0996039 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03930338 0,09950068 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03930338 0,09939768 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03930338 0,09929489 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03930338 0,09919231 ! fibrinolysis GO:0042730 11 7 0,000 0,03930338 0,09908995 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03930338 0,09898779 ! eating behavior GO:0042755 8 7 0,000 0,03930338 0,09888585 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03930338 0,09878411 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03930338 0,09868259 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03930338 0,09858127 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03930338 0,09848016 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03930338 0,09837926 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03930338 0,09827857 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03930338 0,09817808 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03930338 0,09807779 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03930338 0,09797771 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03930338 0,09787784 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03930338 0,09777817 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03930338 0,0976787 ! histone ubiquitination GO:0016574 9 7 0,000 0,03930338 0,09757943 ! regulation of meiosis GO:0040020 12 7 0,000 0,03930338 0,09748036 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03930338 0,0973815 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03930338 0,09728284 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03930338 0,09718437 GO:0002714|positive regulation of B cell mediated immunity, ! membrane to membrane docking GO:0022614 14 7 0,000 0,03930338 0,09708611 ! transcription termination GO:0006353 14 7 0,000 0,03930338 0,09698804 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03930338 0,09689017 ! anaphase GO:0051322 18 7 0,000 0,03930338 0,0967925 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03930338 0,09669502 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03930338 0,09659774 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03930338 0,09650066 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03930338 0,09640377 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03930338 0,09630708 ! diuresis GO:0030146 12 7 0,000 0,03930338 0,09621058 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03930338 0,09611427 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03930338 0,09601816 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03930338 0,09592224 ! antibiotic transport GO:0042891 9 7 0,000 0,03930338 0,09582651 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03930338 0,09573097 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03930338 0,09563562 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03930338 0,09554046 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03930338 0,09544549 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03930338 0,0953507 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03930338 0,09525611 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03930338 0,0951617 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03930338 0,09506748 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03930338 0,09497345 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03930338 0,0948796 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03930338 0,09478594 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03930338 0,09469246 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03930338 0,09459917 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03930338 0,09450606 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03930338 0,09441314 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03930338 0,09432039 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03930338 0,09422783 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03930338 0,09413545 ! muscle adaptation GO:0043500 13 7 0,000 0,03930338 0,09404325 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03930338 0,09395123 ! retina homeostasis GO:0001895 12 7 0,000 0,03930338 0,09385939 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03930338 0,09376773 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03930338 0,09367625 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03930338 0,09358495 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03930338 0,09349383 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,03955011 0,09398923 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,03955011 0,09389789 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03955011 0,09380673 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,03955011 0,09371574 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,04086409 0,09673543 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,04086409 0,09664179 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,04219437 0,09969135 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,04219437 0,09959503 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,04219437 0,0994989 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,04219437 0,09940295 ! heart morphogenesis GO:0003007 105 57 1,000 0,04219437 0,09930718 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,04219437 0,0992116 ! regulation of actin filament length GO:0030832 118 58 1,000 0,04354075 0,10227889 ! sulfur compound biosynthetic process GO:0044272 108 58 1,000 0,04354075 0,10218064 ! aging GO:0007568 112 58 1,000 0,04354075 0,10208258 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,04354075 0,1019847 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,04354075 0,10188701 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04479122 0,10471288 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04479122 0,10461277 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04479122 0,10451285 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04479122 0,10441312 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04479122 0,10431359 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04479122 0,10421424 ! male meiosis GO:0007140 9 8 0,000 0,04479122 0,10411509 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04479122 0,10401612 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04479122 0,10391734 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04479122 0,10381874 ! meiotic prophase I GO:0007128 14 8 0,000 0,04479122 0,10372034 ! response to zinc ion GO:0010043 12 8 0,000 0,04479122 0,10362212 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,04479122 0,10352408 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04479122 0,10342623 ! oligopeptide transport GO:0006857 16 8 0,000 0,04479122 0,10332857 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04479122 0,10323109 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04479122 0,10313379 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04479122 0,10303668 ! signal peptide processing GO:0006465 12 8 0,000 0,04479122 0,10293975 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04479122 0,102843 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04479122 0,10274644 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04479122 0,10265005 ! succinate metabolic process GO:0006105 17 8 0,000 0,04479122 0,10255385 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04479122 0,10245782 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04479122 0,10236198 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04479122 0,10226631 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04479122 0,10217083 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04479122 0,10207552 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04479122 0,10198039 ! reflex GO:0060004 17 8 0,000 0,04479122 0,10188543 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04479122 0,10179066 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04479122 0,10169605 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04479122 0,10160163 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04479122 0,10150738 ! pigment granule organization GO:0048753 17 8 0,000 0,04479122 0,1014133 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04479122 0,1013194 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04479122 0,10122567 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04479122 0,10113212 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04479122 0,10103874 ! histidine catabolic process GO:0006548 10 8 0,000 0,04479122 0,10094553 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04479122 0,10085249 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04479122 0,10075963 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04479122 0,10066693 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04479122 0,10057441 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04479122 0,10048205 ! melanin metabolic process GO:0006582 17 8 0,000 0,04479122 0,10038987 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04479122 0,10029785 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04479122 0,100206 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04479122 0,10011432 ! macrophage activation GO:0042116 13 8 0,000 0,04479122 0,10002281 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04479122 0,09993147 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,04479122 0,09984029 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04479122 0,09974927 ! purine salvage GO:0043101 12 8 0,000 0,04479122 0,09965843 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04479122 0,09956775 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04479122 0,09947723 ! osteoblast development GO:0002076 17 8 0,000 0,04479122 0,09938688 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04479122 0,09929669 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04479122 0,09920667 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04479122 0,09911681 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04479122 0,09902711 ! response to UV-B GO:0010224 17 8 0,000 0,04479122 0,09893757 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04479122 0,0988482 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04479122 0,09875898 ! intermediate filament organization GO:0045109 12 8 0,000 0,04479122 0,09866993 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04479122 0,09858104 ! cellular extravasation GO:0045123 13 8 0,000 0,04479122 0,09849231 ! response to antibiotic GO:0046677 11 8 0,000 0,04479122 0,09840374 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04479122 0,09831532 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04479122 0,09822707 ! DNA topological change GO:0006265 12 8 0,000 0,04479122 0,09813897 ! response to tropane GO:0014073 15 8 0,000 0,04479122 0,09805103 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04479122 0,09796325 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04479122 0,09787563 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04479122 0,09778816 ! mast cell activation GO:0045576 14 8 0,000 0,04479122 0,09770085 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04479122 0,0976137 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04479122 0,0975267 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04479122 0,09743985 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04479122 0,09735316 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04479122 0,09726663 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04479122 0,09718024 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04479122 0,09709401 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04479122 0,09700794 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04479122 0,09692201 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04479122 0,09683624 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04479122 0,09675062 ! response to tumor cell GO:0002347 16 8 0,000 0,04479122 0,09666515 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04479122 0,09657984 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04479122 0,09649467 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04479122 0,09640965 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04479122 0,09632478 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04479122 0,09624007 ! hormone catabolic process GO:0042447 17 8 0,000 0,04479122 0,0961555 ! lymph node development GO:0048535 11 8 0,000 0,04479122 0,09607108 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04479122 0,0959868 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04479122 0,09590268 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04479122 0,0958187 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04479122 0,09573487 ! adult feeding behavior GO:0008343 10 8 0,000 0,04479122 0,09565118 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04479122 0,09556765 ! ATP catabolic process GO:0006200 11 8 0,000 0,04479122 0,09548425 ! blastocyst growth GO:0001832 19 8 0,000 0,04479122 0,09540101 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04479122 0,0953179 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04479122 0,09523495 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04479122 0,09515213 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04479122 0,09506947 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04479122 0,09498694 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04479122 0,09490456 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04479122 0,09482232 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04479122 0,09474022 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04479122 0,09465827 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04479122 0,09457645 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04479122 0,09449478 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04479122 0,09441325 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04479122 0,09433186 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04479122 0,09425061 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04479122 0,0941695 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04479122 0,09408852 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04479122 0,09400769 ! lipid modification GO:0030258 112 60 1,000 0,04628085 0,09705074 ! DNA catabolic process GO:0006308 94 60 1,000 0,04628085 0,09696751 ! positive regulation of secretion GO:0051047 110 61 1,000 0,04767414 0,09980113 ! regulation of cellular component size GO:0032535 125 61 1,000 0,04767414 0,09971568 ! axon extension GO:0048675 16 9 0,000 0,05024787 0,10500902 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,05024787 0,10491927 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05024787 0,10482967 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,05024787 0,10474022 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05024787 0,10465093 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05024787 0,10456179 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,05024787 0,1044728 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,05024787 0,10438396 ! reproductive behavior GO:0019098 22 9 0,000 0,05024787 0,10429528 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05024787 0,10420674 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,05024787 0,10411836 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05024787 0,10403012 ! UTP metabolic process GO:0046051 10 9 0,000 0,05024787 0,10394203 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05024787 0,1038541 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,05024787 0,10376631 ! artery development GO:0060840 25 9 0,000 0,05024787 0,10367867 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,05024787 0,10359117 ! regulation of glycolysis GO:0006110 20 9 0,000 0,05024787 0,10350383 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,05024787 0,10341663 ! equilibrioception GO:0050957 20 9 0,000 0,05024787 0,10332958 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,05024787 0,10324268 ! chemosensory behavior GO:0007635 21 9 0,000 0,05024787 0,10315592 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05024787 0,1030693 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05024787 0,10298284 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05024787 0,10289651 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05024787 0,10281034 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05024787 0,1027243 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05024787 0,10263841 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05024787 0,10255267 ! protein targeting to ER GO:0045047 25 9 0,000 0,05024787 0,10246706 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05024787 0,1023816 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05024787 0,10229628 ! T cell selection GO:0045058 27 9 0,000 0,05024787 0,10221111 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,05024787 0,10212607 ! glycine catabolic process GO:0006546 15 9 0,000 0,05024787 0,10204118 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05024787 0,10195643 ! endosome organization GO:0007032 20 9 0,000 0,05024787 0,10187182 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05024787 0,10178735 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05024787 0,10170302 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05024787 0,10161883 ! mannose metabolic process GO:0006013 13 9 0,000 0,05024787 0,10153477 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05024787 0,10145086 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05024787 0,10136709 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,05024787 0,10128345 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05024787 0,10119995 ! receptor clustering GO:0043113 20 9 0,000 0,05024787 0,10111659 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05024787 0,10103337 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05024787 0,10095028 ! retinol metabolic process GO:0042572 20 9 0,000 0,05024787 0,10086733 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05024787 0,10078452 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,05024787 0,10070184 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05024787 0,1006193 ! macrophage differentiation GO:0030225 15 9 0,000 0,05024787 0,10053689 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05024787 0,10045462 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,05024787 0,10037248 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05024787 0,10029047 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05024787 0,10020861 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05024787 0,10012687 ! response to amine stimulus GO:0014075 13 9 0,000 0,05024787 0,10004527 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05024787 0,0999638 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05024787 0,09988246 ! erythrocyte development GO:0048821 17 9 0,000 0,05024787 0,09980125 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05024787 0,09972018 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,05024787 0,09963924 ! renal water homeostasis GO:0003091 15 9 0,000 0,05024787 0,09955843 ! postreplication repair GO:0006301 25 9 0,000 0,05024787 0,09947775 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05024787 0,0993972 ! icosanoid secretion GO:0032309 15 9 0,000 0,05024787 0,09931678 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05024787 0,09923649 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05024787 0,09915633 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05024787 0,0990763 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05024787 0,0989964 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05024787 0,09891663 ! sterol catabolic process GO:0016127 14 9 0,000 0,05024787 0,09883699 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05024787 0,09875747 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05024787 0,09867809 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05024787 0,09859883 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05024787 0,0985197 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,05024787 0,09844069 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,05024787 0,09836181 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05024787 0,09828306 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05024787 0,09820443 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05024787 0,09812593 ! purine base metabolic process GO:0006144 25 9 0,000 0,05024787 0,09804756 ! pigment granule transport GO:0051904 17 9 0,000 0,05024787 0,09796931 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05024787 0,09789118 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05024787 0,09781318 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05024787 0,0977353 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05024787 0,09765755 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05024787 0,09757992 ! mitochondrion localization GO:0051646 18 9 0,000 0,05024787 0,09750242 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,05050609 0,09792569 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,05050609 0,09784803 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,0533971 0,10336696 ! ear development GO:0043583 114 66 1,000 0,05486422 0,10612295 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,0556735 0,10760312 ! regulation of developmental growth GO:0048638 16 10 0,000 0,0556735 0,10751806 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,0556735 0,10743314 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,0556735 0,10734834 ! associative learning GO:0008306 21 10 0,000 0,0556735 0,10726368 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0556735 0,10717916 ! phosphate transport GO:0006817 24 10 0,000 0,0556735 0,10709476 ! cell volume homeostasis GO:0006884 17 10 0,000 0,0556735 0,1070105 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,0556735 0,10692638 ! CTP metabolic process GO:0046036 11 10 0,000 0,0556735 0,10684238 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,0556735 0,10675852 ! GTP metabolic process GO:0046039 11 10 0,000 0,0556735 0,10667478 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,0556735 0,10659118 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,0556735 0,10650771 ! social behavior GO:0035176 29 10 0,000 0,0556735 0,10642437 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,0556735 0,10634116 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,0556735 0,10625809 ! androgen metabolic process GO:0008209 17 10 0,000 0,0556735 0,10617514 ! phospholipid efflux GO:0033700 19 10 0,000 0,0556735 0,10609232 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0556735 0,10600963 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,0556735 0,10592706 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,0556735 0,10584463 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,0556735 0,10576232 ! pathogenesis GO:0009405 17 10 0,000 0,0556735 0,10568015 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0556735 0,1055981 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,0556735 0,10551618 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,0556735 0,10543438 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,0556735 0,10535271 ! endoderm development GO:0007492 18 10 0,000 0,0556735 0,10527117 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,0556735 0,10518975 ! arginine catabolic process GO:0006527 17 10 0,000 0,0556735 0,10510846 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0556735 0,1050273 ! proline metabolic process GO:0006560 13 10 0,000 0,0556735 0,10494626 ! phosphagen metabolic process GO:0006599 17 10 0,000 0,0556735 0,10486534 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,0556735 0,10478455 ! V(D)J recombination GO:0033151 34 10 0,000 0,0556735 0,10470389 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,0556735 0,10462335 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,0556735 0,10454293 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,0556735 0,10446263 ! B cell proliferation GO:0042100 19 10 0,000 0,0556735 0,10438246 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,0556735 0,10430242 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,0556735 0,10422249 ! multicellular organism growth GO:0035264 19 10 0,000 0,0556735 0,10414269 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,0556735 0,10406301 ! ruffle organization GO:0031529 17 10 0,000 0,0556735 0,10398345 ! epithelial cell development GO:0002064 21 10 0,000 0,0556735 0,10390401 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,0556735 0,10382469 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0556735 0,1037455 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,0556735 0,10366643 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,0556735 0,10358747 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,0556735 0,10350864 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,0556735 0,10342992 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,0556735 0,10335133 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0556735 0,10327285 ! protein heterooligomerization GO:0051291 17 10 0,000 0,0556735 0,1031945 ! brain morphogenesis GO:0048854 23 10 0,000 0,0556735 0,10311626 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,0556735 0,10303814 ! segment specification GO:0007379 15 10 0,000 0,0556735 0,10296014 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,0556735 0,10288226 ! blastoderm segmentation GO:0007350 19 10 0,000 0,0556735 0,1028045 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,0556735 0,10272685 ! response to dsRNA GO:0043331 23 10 0,000 0,0556735 0,10264932 ! DNA ligation GO:0006266 18 10 0,000 0,0556735 0,10257191 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,0556735 0,10249461 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0556735 0,10241743 ! melanosome localization GO:0032400 16 10 0,000 0,0556735 0,10234037 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,0556735 0,10226342 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,0556735 0,10218659 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,0556735 0,10210987 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0556735 0,10203327 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,0556735 0,10195678 ! induction of an organ GO:0001759 17 10 0,000 0,0556735 0,10188041 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,0556735 0,10180415 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,0556735 0,10172801 ! protein sumoylation GO:0016925 17 10 0,000 0,0556735 0,10165198 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,0556735 0,10157606 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0556735 0,10150026 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0556735 0,10142457 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0556735 0,10134899 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,0556735 0,10127353 ! salivary gland development GO:0007431 28 10 0,000 0,0556735 0,10119818 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,0556735 0,10112294 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,0556735 0,10104781 ! midbrain development GO:0030901 14 10 0,000 0,0556735 0,10097279 ! musculoskeletal movement GO:0050881 16 10 0,000 0,0556735 0,10089789 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,0556735 0,10082309 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,0556735 0,10074841 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,0556735 0,10067383 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,0556735 0,10059937 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,0556735 0,10052502 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0556735 0,10045078 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0556735 0,10037664 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,0556735 0,10030262 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,0556735 0,1002287 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,0556735 0,1001549 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0556735 0,1000812 ! blastocyst formation GO:0001825 18 10 0,000 0,0556735 0,10000761 ! cerebellar cortex development GO:0021695 16 10 0,000 0,0556735 0,09993413 ! positive regulation of amine transport GO:0051954 17 10 0,000 0,0556735 0,09986076 ! response to nicotine GO:0035094 20 10 0,000 0,0556735 0,09978749 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,0556735 0,09971433 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,05634547 0,10084395 ! activation of MAPK activity GO:0000187 124 67 1,000 0,05634547 0,10077012 ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,05634547 0,10069641 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,05784065 0,10329291 ! detection of external stimulus GO:0009581 102 68 1,000 0,05784065 0,10321746 ! regulation of lipase activity GO:0060191 137 68 1,000 0,05784065 0,10314212 ! adaptive immune response GO:0002250 126 68 1,000 0,05784065 0,10306689 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,05784065 0,10299177 ! cell projection assembly GO:0030031 138 68 1,000 0,05784065 0,10291676 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,05934955 0,1055247 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,05934955 0,10544796 ! developmental maturation GO:0021700 128 69 1,000 0,05934955 0,10537132 ! germ cell development GO:0007281 133 70 1,000 0,06087196 0,10799578 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,06106828 0,10826546 ! respiratory burst GO:0045730 17 11 0,000 0,06106828 0,10818695 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,06106828 0,10810856 ! neuron fate specification GO:0048665 18 11 0,000 0,06106828 0,10803027 ! telencephalon cell migration GO:0022029 23 11 0,000 0,06106828 0,1079521 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06106828 0,10787405 ! thyroid gland development GO:0030878 26 11 0,000 0,06106828 0,1077961 ! synapsis GO:0007129 14 11 0,000 0,06106828 0,10771827 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06106828 0,10764055 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,06106828 0,10756295 ! response to pain GO:0048265 27 11 0,000 0,06106828 0,10748545 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06106828 0,10740807 ! bone resorption GO:0045453 16 11 0,000 0,06106828 0,1073308 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06106828 0,10725364 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06106828 0,10717659 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06106828 0,10709965 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06106828 0,10702282 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06106828 0,1069461 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06106828 0,10686949 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,06106828 0,10679299 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,06106828 0,1067166 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,06106828 0,10664032 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,06106828 0,10656415 ! UV protection GO:0009650 20 11 0,000 0,06106828 0,10648809 ! adult heart development GO:0007512 16 11 0,000 0,06106828 0,10641213 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06106828 0,10633629 ! macroautophagy GO:0016236 19 11 0,000 0,06106828 0,10626055 ! temperature homeostasis GO:0001659 18 11 0,000 0,06106828 0,10618492 ! behavioral fear response GO:0001662 27 11 0,000 0,06106828 0,10610939 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06106828 0,10603398 ! negative regulation of ossification GO:0030279 27 11 0,000 0,06106828 0,10595867 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,06106828 0,10588347 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,06106828 0,10580838 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06106828 0,10573339 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,06106828 0,1056585 ! regulation of organ growth GO:0046620 14 11 0,000 0,06106828 0,10558373 ! pigment granule localization GO:0051875 20 11 0,000 0,06106828 0,10550906 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06106828 0,10543449 ! vasoconstriction GO:0042310 20 11 0,000 0,06106828 0,10536003 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06106828 0,10528568 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06106828 0,10521143 ! embryonic axis specification GO:0000578 19 11 0,000 0,06106828 0,10513729 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06106828 0,10506325 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06106828 0,10498931 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06106828 0,10491548 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,06106828 0,10484175 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,06106828 0,10476812 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06106828 0,1046946 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06106828 0,10462118 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06106828 0,10454787 ! prophase GO:0051324 17 11 0,000 0,06106828 0,10447466 ! nucleosome positioning GO:0016584 15 11 0,000 0,06106828 0,10440155 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06106828 0,10432854 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06106828 0,10425563 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06106828 0,10418283 ! apical protein localization GO:0045176 18 11 0,000 0,06106828 0,10411012 ! acid secretion GO:0046717 20 11 0,000 0,06106828 0,10403752 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06106828 0,10396502 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06106828 0,10389262 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06106828 0,10382033 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06106828 0,10374813 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06106828 0,10367603 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,06106828 0,10360403 ! cholesterol efflux GO:0033344 21 11 0,000 0,06106828 0,10353214 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06106828 0,10346034 ! oocyte development GO:0048599 20 11 0,000 0,06106828 0,10338864 ! germ cell migration GO:0008354 26 11 0,000 0,06106828 0,10331704 ! embryonic gut development GO:0048566 19 11 0,000 0,06106828 0,10324554 ! activation of innate immune response GO:0002218 16 11 0,000 0,06106828 0,10317414 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06106828 0,10310284 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,06106828 0,10303164 ! lysogeny GO:0030069 22 11 0,000 0,06106828 0,10296053 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06106828 0,10288952 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06106828 0,10281861 ! sequestering of metal ion GO:0051238 15 11 0,000 0,06106828 0,1027478 ! regulation of embryonic development GO:0045995 35 11 0,000 0,06106828 0,10267709 ! nucleus localization GO:0051647 22 11 0,000 0,06106828 0,10260647 ! carbohydrate transport GO:0008643 114 72 1,000 0,06395651 0,1073854 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,06395651 0,10731165 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,06395651 0,107238 ! coenzyme biosynthetic process GO:0009108 119 72 1,000 0,06395651 0,10716445 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,06395651 0,107091 ! humoral immune response GO:0006959 115 73 1,000 0,06551826 0,1096309 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,0664324 0,11108442 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0664324 0,11100844 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,0664324 0,11093257 ! virus-host interaction GO:0019048 30 12 0,000 0,0664324 0,11085679 ! mating GO:0007618 17 12 0,000 0,0664324 0,11078112 ! protein complex disassembly GO:0043241 28 12 0,000 0,0664324 0,11070556 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,0664324 0,11063009 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,0664324 0,11055473 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,0664324 0,11047947 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0664324 0,11040432 ! T cell proliferation GO:0042098 32 12 0,000 0,0664324 0,11032926 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0664324 0,11025431 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0664324 0,11017946 ! ventral spinal cord development GO:0021517 25 12 0,000 0,0664324 0,11010471 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0664324 0,11003006 ! drug transport GO:0015893 16 12 0,000 0,0664324 0,10995552 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0664324 0,10988107 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0664324 0,10980673 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0664324 0,10973248 ! polyamine metabolic process GO:0006595 18 12 0,000 0,0664324 0,10965834 ! focal adhesion formation GO:0048041 37 12 0,000 0,0664324 0,1095843 ! mitotic spindle organization GO:0007052 23 12 0,000 0,0664324 0,10951035 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0664324 0,10943651 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0664324 0,10936277 ! lipid digestion GO:0044241 21 12 0,000 0,0664324 0,10928912 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0664324 0,10921558 ! entry into host cell GO:0030260 34 12 0,000 0,0664324 0,10914213 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0664324 0,10906878 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0664324 0,10899553 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0664324 0,10892238 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0664324 0,10884933 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0664324 0,10877637 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0664324 0,10870351 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,0664324 0,10863075 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0664324 0,10855809 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0664324 0,10848552 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,0664324 0,10841306 ! cranial nerve development GO:0021545 23 12 0,000 0,0664324 0,10834068 ! fucose catabolic process GO:0019317 25 12 0,000 0,0664324 0,10826841 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0664324 0,10819623 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0664324 0,10812415 ! autonomic nervous system development GO:0048483 24 12 0,000 0,0664324 0,10805216 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,0664324 0,10798027 ! zymogen activation GO:0031638 18 12 0,000 0,0664324 0,10790847 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0664324 0,10783677 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0664324 0,10776517 ! oocyte differentiation GO:0009994 21 12 0,000 0,0664324 0,10769366 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0664324 0,10762224 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0664324 0,10755092 ! defense response to fungus GO:0050832 15 12 0,000 0,0664324 0,1074797 ! developmental induction GO:0031128 22 12 0,000 0,0664324 0,10740857 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,0664324 0,10733753 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0664324 0,10726659 ! response to cold GO:0009409 17 12 0,000 0,0664324 0,10719574 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0664324 0,10712498 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0664324 0,10705432 ! acute inflammatory response GO:0002526 118 74 1,000 0,06709273 0,10804716 ! regulation of caspase activity GO:0043281 136 74 1,000 0,06709273 0,10797598 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,06867972 0,11045725 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 1,000 0,06867972 0,11038458 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,06867972 0,11031201 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,07027905 0,11280664 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,07027905 0,11273258 ! learning or memory GO:0007611 161 76 1,000 0,07027905 0,1126586 ! regulation of blood pressure GO:0008217 134 76 1,000 0,07027905 0,11258473 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07176602 0,11489147 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07176602 0,11481623 ! regulation of chemokine production GO:0032642 18 13 0,000 0,07176602 0,11474109 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07176602 0,11466604 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,07176602 0,1145911 ! peroxisomal transport GO:0043574 28 13 0,000 0,07176602 0,11451625 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07176602 0,1144415 ! cartilage condensation GO:0001502 22 13 0,000 0,07176602 0,11436685 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,07176602 0,1142923 ! organelle fusion GO:0048284 36 13 0,000 0,07176602 0,11421784 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07176602 0,11414348 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07176602 0,11406921 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07176602 0,11399505 ! endocrine pancreas development GO:0031018 25 13 0,000 0,07176602 0,11392098 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07176602 0,113847 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07176602 0,11377312 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07176602 0,11369934 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,07176602 0,11362565 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07176602 0,11355206 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,07176602 0,11347856 ! methionine metabolic process GO:0006555 31 13 0,000 0,07176602 0,11340516 ! plasma membrane organization GO:0007009 27 13 0,000 0,07176602 0,11333186 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,07176602 0,11325864 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07176602 0,11318553 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,07176602 0,1131125 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,07176602 0,11303958 ! cytokine metabolic process GO:0042107 24 13 0,000 0,07176602 0,11296674 ! exocrine system development GO:0035272 34 13 0,000 0,07176602 0,112894 ! asymmetric protein localization GO:0008105 24 13 0,000 0,07176602 0,11282135 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07176602 0,1127488 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07176602 0,11267634 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,07176602 0,11260397 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,07176602 0,1125317 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,07176602 0,11245951 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07176602 0,11238742 ! protein homotetramerization GO:0051289 24 13 0,000 0,07176602 0,11231543 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07176602 0,11224352 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07176602 0,11217171 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07176602 0,11209999 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07176602 0,11202836 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,07176602 0,11195682 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07176602 0,11188537 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07176602 0,11181402 ! histone methylation GO:0016571 29 13 0,000 0,07176602 0,11174275 ! chromatin silencing GO:0006342 29 13 0,000 0,07176602 0,11167158 ! gland morphogenesis GO:0022612 31 13 0,000 0,07176602 0,1116005 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,07176602 0,1115295 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,07176602 0,1114586 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07176602 0,11138779 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,07176602 0,11131707 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,07176602 0,11124643 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07176602 0,11117589 ! spleen development GO:0048536 24 13 0,000 0,07176602 0,11110544 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,07176602 0,11103507 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07176602 0,1109648 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07176602 0,11089461 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,07176602 0,11082451 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07176602 0,1107545 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,07176602 0,11068458 ! insulin secretion GO:0030073 24 13 0,000 0,07176602 0,11061475 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07176602 0,11054501 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,07176602 0,11047535 ! acrosome reaction GO:0007340 19 13 0,000 0,07176602 0,11040578 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,07176602 0,1103363 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,07176602 0,11026691 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,07189051 0,11038876 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,07189051 0,11031942 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,07189051 0,11025017 ! regulation of catabolic process GO:0009894 173 77 1,000 0,07189051 0,110181 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,07351392 0,11259844 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,0751491 0,11503086 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,0751491 0,11495883 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,0751491 0,11488689 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,0751491 0,11481504 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,07679586 0,11725767 ! rRNA transcription GO:0009303 28 14 0,000 0,07706932 0,11760171 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07706932 0,1175283 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07706932 0,11745498 ! water transport GO:0006833 21 14 0,000 0,07706932 0,11738176 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07706932 0,11730862 ! non-recombinational repair GO:0000726 29 14 0,000 0,07706932 0,11723558 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07706932 0,11716263 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07706932 0,11708976 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,07706932 0,11701699 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07706932 0,11694431 ! palate development GO:0060021 32 14 0,000 0,07706932 0,11687172 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07706932 0,11679922 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07706932 0,11672681 ! arginine metabolic process GO:0006525 21 14 0,000 0,07706932 0,11665449 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07706932 0,11658225 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,07706932 0,11651011 ! regulation of heart rate GO:0002027 25 14 0,000 0,07706932 0,11643806 ! fear response GO:0042596 34 14 0,000 0,07706932 0,11636609 ! organic alcohol transport GO:0015850 29 14 0,000 0,07706932 0,11629422 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07706932 0,11622243 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,07706932 0,11615073 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,07706932 0,11607912 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07706932 0,1160076 ! bone mineralization GO:0030282 18 14 0,000 0,07706932 0,11593617 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07706932 0,11586482 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07706932 0,11579357 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07706932 0,1157224 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,07706932 0,11565131 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07706932 0,11558032 ! regulation of cellular pH GO:0030641 27 14 0,000 0,07706932 0,11550941 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07706932 0,11543859 ! ribosome assembly GO:0042255 18 14 0,000 0,07706932 0,11536785 ! cerebellum development GO:0021549 23 14 0,000 0,07706932 0,11529721 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07706932 0,11522665 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07706932 0,11515617 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07706932 0,11508578 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07706932 0,11501548 ! NADP metabolic process GO:0006739 24 14 0,000 0,07706932 0,11494526 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07706932 0,11487513 ! oxygen transport GO:0015671 22 14 0,000 0,07706932 0,11480508 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07706932 0,11473512 ! male genitalia development GO:0030539 26 14 0,000 0,07706932 0,11466525 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07706932 0,11459546 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,07706932 0,11452575 ! muscle cell differentiation GO:0042692 178 81 1,000 0,078454 0,11651254 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,08012336 0,11891943 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,08012336 0,11884722 ! protein import into nucleus GO:0006606 174 82 1,000 0,08012336 0,11877511 ! nuclear import GO:0051170 177 83 1,000 0,08180375 0,12119258 ! inorganic anion transport GO:0015698 156 83 1,000 0,08180375 0,12111913 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,08234246 0,12184291 ! lactation GO:0007595 30 15 0,000 0,08234246 0,12176915 ! reproductive cellular process GO:0048610 22 15 0,000 0,08234246 0,12169549 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08234246 0,12162191 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,08234246 0,12154842 ! superoxide anion generation GO:0042554 22 15 0,000 0,08234246 0,12147502 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,08234246 0,12140171 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,08234246 0,12132849 ! copper ion transport GO:0006825 22 15 0,000 0,08234246 0,12125536 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,08234246 0,12118231 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,08234246 0,12110935 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,08234246 0,12103649 ! response to cAMP GO:0051591 25 15 0,000 0,08234246 0,1209637 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,08234246 0,12089101 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,08234246 0,1208184 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,08234246 0,12074588 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,08234246 0,12067345 ! vesicle coating GO:0006901 38 15 0,000 0,08234246 0,1206011 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,08234246 0,12052884 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,08234246 0,12045667 ! regulation of exocytosis GO:0017157 26 15 0,000 0,08234246 0,12038458 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,08234246 0,12031258 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,08234246 0,12024067 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,08234246 0,12016884 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,08234246 0,1200971 ! regulation of vasodilation GO:0042312 27 15 0,000 0,08234246 0,12002544 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,08234246 0,11995387 ! histone deacetylation GO:0016575 24 15 0,000 0,08234246 0,11988238 ! water homeostasis GO:0030104 28 15 0,000 0,08234246 0,11981098 ! cofactor transport GO:0051181 30 15 0,000 0,08234246 0,11973967 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08234246 0,11966843 ! muscle maintenance GO:0046716 26 15 0,000 0,08234246 0,11959729 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,08234246 0,11952623 ! intestinal absorption GO:0050892 31 15 0,000 0,08234246 0,11945525 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08234246 0,11938436 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,08234246 0,11931355 ! heme biosynthetic process GO:0006783 33 15 0,000 0,08234246 0,11924282 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,08234246 0,11917218 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,08234246 0,11910162 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,08234246 0,11903115 ! actin filament polymerization GO:0030041 27 15 0,000 0,08234246 0,11896076 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,08234246 0,11889045 ! response to metal ion GO:0010038 158 84 1,000 0,083495 0,12048333 ! regulation of ligase activity GO:0051340 147 84 1,000 0,083495 0,1204122 ! negative regulation of growth GO:0045926 168 85 1,000 0,08519691 0,12279413 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,08758563 0,12616256 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,08758563 0,12608821 ! positive regulation of cell size GO:0045793 29 16 0,000 0,08758563 0,12601395 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,08758563 0,12593979 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,08758563 0,1258657 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,08758563 0,12579171 ! bone remodeling GO:0046849 28 16 0,000 0,08758563 0,1257178 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,08758563 0,12564398 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08758563 0,12557024 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,08758563 0,1254966 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,08758563 0,12542303 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,08758563 0,12534956 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,08758563 0,12527617 ! startle response GO:0001964 28 16 0,000 0,08758563 0,12520286 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,08758563 0,12512965 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,08758563 0,12505651 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,08758563 0,12498347 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,08758563 0,12491051 ! protein polyubiquitination GO:0000209 41 16 0,000 0,08758563 0,12483763 ! glutamate metabolic process GO:0006536 25 16 0,000 0,08758563 0,12476484 ! pituitary gland development GO:0021983 30 16 0,000 0,08758563 0,12469213 ! response to osmotic stress GO:0006970 27 16 0,000 0,08758563 0,12461951 ! lysosomal transport GO:0007041 31 16 0,000 0,08758563 0,12454697 ! L-amino acid transport GO:0015807 33 16 0,000 0,08758563 0,12447452 ! stem cell development GO:0048864 46 16 0,000 0,08758563 0,12440215 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08758563 0,12432986 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08758563 0,12425766 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,08758563 0,12418555 ! negative regulation of immune response GO:0050777 38 16 0,000 0,08758563 0,12411351 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,08758563 0,12404156 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,08758563 0,1239697 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,08758563 0,12389791 ! DNA replication initiation GO:0006270 28 16 0,000 0,08758563 0,12382621 ! mRNA splice site selection GO:0006376 44 16 0,000 0,08758563 0,1237546 ! tissue regeneration GO:0042246 27 16 0,000 0,08758563 0,12368306 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,08758563 0,12361161 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,08758563 0,12354024 ! biomineral formation GO:0031214 22 16 0,000 0,08758563 0,12346895 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,08758563 0,12339775 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,08758563 0,12332663 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,08758563 0,12325558 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08758563 0,12318463 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,08758563 0,12311375 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,08758563 0,12304295 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,08758563 0,12297224 ! peptide hormone processing GO:0016486 27 16 0,000 0,08758563 0,12290161 ! regulation of protein transport GO:0051223 165 87 1,000 0,08863206 0,12429858 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 167 89 1,000 0,09210783 0,12909893 ! tube morphogenesis GO:0035239 194 89 1,000 0,09210783 0,1290249 ! protein localization in nucleus GO:0034504 192 89 1,000 0,09210783 0,12895096 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,09279899 0,12984417 ! metencephalon development GO:0022037 32 17 0,000 0,09279899 0,12976985 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,09279899 0,12969561 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,09279899 0,12962145 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,09279899 0,12954739 ! signal complex assembly GO:0007172 47 17 0,000 0,09279899 0,1294734 ! filopodium assembly GO:0046847 42 17 0,000 0,09279899 0,1293995 ! endothelial cell migration GO:0043542 31 17 0,000 0,09279899 0,12932568 ! gene silencing by RNA GO:0031047 38 17 0,000 0,09279899 0,12925195 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,09279899 0,1291783 ! glial cell development GO:0021782 28 17 0,000 0,09279899 0,12910474 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,09279899 0,12903126 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,09279899 0,12895786 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,09279899 0,12888455 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,09279899 0,12881132 ! myoblast differentiation GO:0045445 50 17 0,000 0,09279899 0,12873817 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,09279899 0,12866511 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,09279899 0,12859213 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,09279899 0,12851923 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,09279899 0,12844642 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,09279899 0,12837368 ! NAD metabolic process GO:0019674 33 17 0,000 0,09279899 0,12830103 ! membrane budding GO:0006900 42 17 0,000 0,09279899 0,12822846 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,09279899 0,12815598 ! regulation of protein binding GO:0043393 33 17 0,000 0,09279899 0,12808357 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,09279899 0,12801125 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,09279899 0,12793901 ! genitalia development GO:0048806 32 17 0,000 0,09279899 0,12786685 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,09279899 0,12779477 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,09279899 0,12772277 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,09279899 0,12765086 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,09279899 0,12757902 ! steroid catabolic process GO:0006706 34 17 0,000 0,09279899 0,12750727 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,09279899 0,1274356 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,09279899 0,127364 ! gas transport GO:0015669 26 17 0,000 0,09279899 0,12729249 ! organic cation transport GO:0015695 32 17 0,000 0,09279899 0,12722106 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,09279899 0,12714971 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,09279899 0,12707843 ! response to inorganic substance GO:0010035 173 90 1,000 0,09386052 0,12846008 ! gland development GO:0048732 220 91 1,000 0,09562285 0,13079878 ! defense response to bacterium GO:0042742 112 91 1,000 0,09562285 0,13072558 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,0979827 0,13387681 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,0979827 0,13380198 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,0979827 0,13372723 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0979827 0,13365256 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,0979827 0,13357798 ! heart looping GO:0001947 34 18 0,000 0,0979827 0,13350348 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,0979827 0,13342906 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,0979827 0,13335473 ! centrosome cycle GO:0007098 26 18 0,000 0,0979827 0,13328048 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,0979827 0,13320631 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,0979827 0,13313222 ! glycine metabolic process GO:0006544 30 18 0,000 0,0979827 0,13305822 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0979827 0,1329843 ! response to retinoic acid GO:0032526 31 18 0,000 0,0979827 0,13291046 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,0979827 0,1328367 ! DNA integration GO:0015074 32 18 0,000 0,0979827 0,13276303 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,0979827 0,13268943 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,0979827 0,13261592 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,0979827 0,13254249 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,0979827 0,13246914 ! neural crest cell migration GO:0001755 41 18 0,000 0,0979827 0,13239587 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,0979827 0,13232269 ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,0979827 0,13224958 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,0979827 0,13217655 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,0979827 0,13210361 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,0979827 0,13203074 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,0979827 0,13195796 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,0979827 0,13188525 ! detection of bacterium GO:0016045 22 18 0,000 0,0979827 0,13181263 ! nerve development GO:0021675 34 18 0,000 0,0979827 0,13174009 ! defense response to virus GO:0051607 43 18 0,000 0,0979827 0,13166762 ! microspike assembly GO:0030035 46 18 0,000 0,0979827 0,13159524 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,0979827 0,13152293 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,09917578 0,13305131 GO:0010498|proteasomal protein catabolic process, ! cofactor biosynthetic process GO:0051188 161 95 1,000 0,10276532 0,13779126 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,10313694 0,13821368 ! negative regulation of defense response GO:0031348 27 19 0,000 0,10313694 0,13813791 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,10313694 0,13806222 ! neuron maturation GO:0042551 46 19 0,000 0,10313694 0,13798661 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,10313694 0,13791108 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,10313694 0,13783564 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,10313694 0,13776028 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,10313694 0,137685 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,10313694 0,1376098 ! inositol metabolic process GO:0006020 33 19 0,000 0,10313694 0,13753469 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,10313694 0,13745965 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,10313694 0,1373847 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,10313694 0,13730983 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,10313694 0,13723505 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,10313694 0,13716034 ! cerebral cortex development GO:0021987 40 19 0,000 0,10313694 0,13708572 ! pigmentation during development GO:0048066 42 19 0,000 0,10313694 0,13701117 ! response to vitamin A GO:0033189 32 19 0,000 0,10313694 0,13693671 ! heme metabolic process GO:0042168 40 19 0,000 0,10313694 0,13686233 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,10313694 0,13678803 ! response to fungus GO:0009620 26 19 0,000 0,10313694 0,13671381 ! protein export from nucleus GO:0006611 40 19 0,000 0,10313694 0,13663967 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,10313694 0,13656561 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,10313694 0,13649163 ! visual learning GO:0008542 38 19 0,000 0,10313694 0,13641773 ! cellular pigmentation GO:0033059 37 19 0,000 0,10313694 0,13634391 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,10313694 0,13627017 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,10313694 0,13619651 ! vitamin transport GO:0051180 31 19 0,000 0,10313694 0,13612293 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,10313694 0,13604943 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,10313694 0,13597601 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,10313694 0,13590267 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,10313694 0,1358294 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,10313694 0,13575622 ! cilium assembly GO:0042384 38 19 0,000 0,10313694 0,13568312 ! peptide hormone secretion GO:0030072 32 19 0,000 0,10313694 0,13561009 ! regulation of T cell activation GO:0050863 175 96 1,000 0,10457342 0,13742489 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 0,10639019 0,13973722 ! transcription initiation GO:0006352 171 97 1,000 0,10639019 0,13966213 ! regulation of protein localization GO:0032880 188 97 1,000 0,10639019 0,13958713 ! forebrain development GO:0030900 210 98 1,000 0,10821547 0,14190574 ! protein secretion GO:0009306 45 20 0,000 0,10826187 0,14189043 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,10826187 0,14181434 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,10826187 0,14173835 ! positive regulation of ossification GO:0045778 50 20 0,000 0,10826187 0,14166243 ! skin development GO:0043588 42 20 0,000 0,10826187 0,14158659 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,10826187 0,14151084 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,10826187 0,14143516 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,10826187 0,14135957 ! response to vitamin GO:0033273 36 20 0,000 0,10826187 0,14128406 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,10826187 0,14120862 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,10826187 0,14113327 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,10826187 0,141058 ! bile acid metabolic process GO:0008206 34 20 0,000 0,10826187 0,14098281 ! retinoid metabolic process GO:0001523 34 20 0,000 0,10826187 0,1409077 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,10826187 0,14083267 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,10826187 0,14075772 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,10826187 0,14068285 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,10826187 0,14060806 ! body fluid secretion GO:0007589 33 20 0,000 0,10826187 0,14053334 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,10826187 0,14045871 ! peptide secretion GO:0002790 38 20 0,000 0,10826187 0,14038416 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,10826187 0,14030968 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,10826187 0,14023529 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,10826187 0,14016097 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,10826187 0,14008673 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,10826187 0,14001257 ! cell-cell junction organization GO:0045216 43 20 0,000 0,10826187 0,13993849 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,10826187 0,13986449 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,10826187 0,13979057 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,10826187 0,13971672 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,10826187 0,13964295 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,10826187 0,13956926 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,10826187 0,13949565 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,10826187 0,13942212 ! regulation of cell killing GO:0031341 46 21 0,000 0,11335766 0,14590768 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,11335766 0,14583084 ! hormone secretion GO:0046879 39 21 0,000 0,11335766 0,14575409 ! cAMP metabolic process GO:0046058 41 21 0,000 0,11335766 0,14567742 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,11335766 0,14560082 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,11335766 0,14552431 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,11335766 0,14544788 ! ovarian follicle development GO:0001541 39 21 0,000 0,11335766 0,14537153 ! smooth muscle contraction GO:0006939 48 21 0,000 0,11335766 0,14529526 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,11335766 0,14521907 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,11335766 0,14514296 ! plasma membrane fusion GO:0045026 33 21 0,000 0,11335766 0,14506693 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,11335766 0,14499098 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,11335766 0,14491511 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,11335766 0,14483931 ! sensory perception of pain GO:0019233 33 21 0,000 0,11335766 0,1447636 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,11335766 0,14468797 ! diencephalon development GO:0021536 36 21 0,000 0,11335766 0,14461241 ! collagen fibril organization GO:0030199 62 21 0,000 0,11335766 0,14453694 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,11335766 0,14446154 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,11335766 0,14438622 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,11335766 0,14431098 ! collagen catabolic process GO:0030574 29 21 0,000 0,11335766 0,14423582 ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,11335766 0,14416073 ! sperm-egg recognition GO:0035036 23 21 0,000 0,11335766 0,14408573 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,11335766 0,1440108 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,11842447 0,15036954 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,11842447 0,15029142 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,11842447 0,15021339 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,11842447 0,15013544 GO:0034105|positive regulation of tissue remodeling, ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,11842447 0,15005757 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,11842447 0,14997978 ! cellular response to starvation GO:0009267 37 22 0,000 0,11842447 0,14990207 ! vacuolar transport GO:0007034 41 22 0,000 0,11842447 0,14982444 ! central nervous system neuron development GO:0021954 47 22 0,000 0,11842447 0,14974689 ! fucose metabolic process GO:0006004 44 22 0,000 0,11842447 0,14966942 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,11842447 0,14959203 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,11842447 0,14951472 ! ureteric bud development GO:0001657 50 22 0,000 0,11842447 0,1494375 ! cell aging GO:0007569 48 22 0,000 0,11842447 0,14936035 ! stem cell differentiation GO:0048863 57 22 0,000 0,11842447 0,14928328 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,11842447 0,14920629 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,11842447 0,14912938 ! cytolysis GO:0019835 27 22 0,000 0,11842447 0,14905255 ! renal system process GO:0003014 42 22 0,000 0,11842447 0,14897579 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,11842447 0,14889912 ! G1 phase GO:0051318 44 22 0,000 0,11842447 0,14882253 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,11842447 0,14874601 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,11842447 0,14866957 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,11842447 0,14859322 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,11842447 0,14851694 ! sarcomere organization GO:0045214 32 22 0,000 0,11842447 0,14844073 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,11842447 0,14836461 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,11842447 0,14828857 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,11842447 0,1482126 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,11842447 0,14813671 ! gut development GO:0048565 44 22 0,000 0,11842447 0,1480609 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,11842447 0,14798516 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,11842447 0,1479095 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,11842447 0,14783393 ! protein stabilization GO:0050821 41 22 0,000 0,11842447 0,14775842 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,12346247 0,15396571 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,12346247 0,15388716 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,12346247 0,15380868 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,12346247 0,15373029 ! gluconeogenesis GO:0006094 38 23 0,000 0,12346247 0,15365197 ! glycerol metabolic process GO:0006071 40 23 0,000 0,12346247 0,15357374 ! viral genome replication GO:0019079 44 23 0,000 0,12346247 0,15349559 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,12346247 0,15341751 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,12346247 0,15333951 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,12346247 0,1532616 ! regeneration GO:0031099 42 23 0,000 0,12346247 0,15318376 ! axis specification GO:0009798 43 23 0,000 0,12346247 0,153106 ! visual behavior GO:0007632 46 23 0,000 0,12346247 0,15302832 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,12346247 0,15295072 ! response to ethanol GO:0045471 47 23 0,000 0,12346247 0,1528732 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,12346247 0,15279576 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,12346247 0,15271839 ! peroxisome organization GO:0007031 43 23 0,000 0,12346247 0,15264111 ! vesicle targeting GO:0006903 49 23 0,000 0,12346247 0,1525639 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,12346247 0,15248677 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,12346247 0,15240971 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,12346247 0,15233274 ! DNA modification GO:0006304 36 23 0,000 0,12346247 0,15225584 ! fatty acid transport GO:0015908 47 23 0,000 0,12346247 0,15217902 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,12346247 0,15210228 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,12346247 0,15202562 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,12346247 0,15194903 ! hormone transport GO:0009914 41 23 0,000 0,12346247 0,15187252 ! cell-cell recognition GO:0009988 28 23 0,000 0,12346247 0,15179609 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,12346247 0,15171973 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,12847182 0,15779621 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,12847182 0,15771692 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,12847182 0,1576377 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,12847182 0,15755857 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,12847182 0,15747951 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,12847182 0,15740054 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,12847182 0,15732164 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,12847182 0,15724282 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,12847182 0,15716408 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,12847182 0,15708542 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,12847182 0,15700684 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,12847182 0,15692833 ! sex determination GO:0007530 48 24 0,000 0,12847182 0,15684991 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,12847182 0,15677156 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,12847182 0,15669329 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,12847182 0,1566151 ! membrane depolarization GO:0051899 45 24 0,000 0,12847182 0,15653699 ! oogenesis GO:0048477 44 24 0,000 0,12847182 0,15645896 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,12847182 0,156381 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,12847182 0,15630312 ! platelet activation GO:0030168 41 24 0,000 0,12847182 0,15622532 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,12847182 0,1561476 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,12847182 0,15606995 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,12847182 0,15599238 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,12847182 0,15591489 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,12847182 0,15583747 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,12847182 0,15576013 ! regulation of amine transport GO:0051952 41 24 0,000 0,12847182 0,15568287 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,13345269 0,16163853 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,13345269 0,16155843 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,13345269 0,16147841 ! phototransduction GO:0007602 37 25 0,000 0,13345269 0,16139847 ! keratinization GO:0031424 37 25 0,000 0,13345269 0,16131861 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,13345269 0,16123883 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,13345269 0,16115913 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,13345269 0,1610795 ! receptor metabolic process GO:0043112 53 25 0,000 0,13345269 0,16099996 ! chromosome condensation GO:0030261 48 25 0,000 0,13345269 0,16092049 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,13345269 0,1608411 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,13345269 0,16076179 ! interaction with host GO:0051701 66 25 0,000 0,13345269 0,16068256 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,13345269 0,16060341 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,13345269 0,16052433 ! immunoglobulin production GO:0002377 62 25 0,000 0,13345269 0,16044533 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,13345269 0,16036641 ! liver development GO:0001889 55 25 0,000 0,13345269 0,16028757 ! protein tetramerization GO:0051262 57 25 0,000 0,13345269 0,1602088 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,13840522 0,16607267 ! initiation of viral infection GO:0019059 60 26 0,000 0,13840522 0,16599114 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,13840522 0,16590969 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,13840522 0,16582833 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,13840522 0,16574704 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,13840522 0,16566583 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,13840522 0,1655847 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,13840522 0,16550365 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,13840522 0,16542268 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,13840522 0,16534179 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,13840522 0,16526098 ! digestive system process GO:0022600 49 26 0,000 0,13840522 0,16518024 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,13840522 0,16509959 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,13840522 0,16501901 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,13840522 0,16493852 ! osteoblast differentiation GO:0001649 63 26 0,000 0,13840522 0,1648581 ! neural crest cell development GO:0014032 59 26 0,000 0,13840522 0,16477776 GO:0014033|neural crest cell differentiation, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,13840522 0,16469749 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,13840522 0,16461731 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,13840522 0,16453721 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,13840522 0,16445718 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,13840522 0,16437723 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,13840522 0,16429736 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,13840522 0,16421756 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,13840522 0,16413784 ! blastocyst development GO:0001824 50 26 0,000 0,13840522 0,1640582 ! telomere organization GO:0032200 46 26 0,000 0,13840522 0,16397864 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,13840522 0,16389916 ! neural tube closure GO:0001843 58 26 0,000 0,13840522 0,16381975 GO:0060606|tube closure, ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,13840522 0,16374042 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,13840522 0,16366116 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,14332959 0,16940212 ! embryonic pattern specification GO:0009880 49 27 0,000 0,14332959 0,16932021 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,14332959 0,16923837 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,14332959 0,16915661 ! tube lumen formation GO:0035148 59 27 0,000 0,14332959 0,16907494 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,14332959 0,16899334 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,14332959 0,16891181 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,14332959 0,16883037 ! response to starvation GO:0042594 47 27 0,000 0,14332959 0,16874901 ! response to toxin GO:0009636 49 27 0,000 0,14332959 0,16866772 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,14332959 0,16858651 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,14332959 0,16850539 ! leukocyte proliferation GO:0070661 59 27 0,000 0,14332959 0,16842433 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,14822595 0,17409423 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,14822595 0,17401057 ! vesicle docking GO:0048278 55 28 0,000 0,14822595 0,17392699 ! circadian rhythm GO:0007623 56 28 0,000 0,14822595 0,1738435 ! fat cell differentiation GO:0045444 57 28 0,000 0,14822595 0,17376008 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,14822595 0,17367674 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,14822595 0,17359348 ! base-excision repair GO:0006284 41 28 0,000 0,14822595 0,1735103 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,14822595 0,1734272 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,14822595 0,17334419 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,14822595 0,17326125 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,14822595 0,17317839 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,14822595 0,1730956 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,14822595 0,1730129 ! lipid oxidation GO:0034440 48 28 0,000 0,14822595 0,17293028 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,14822595 0,17284773 ! translational initiation GO:0006413 66 29 0,000 0,15309447 0,17843978 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,15309447 0,17835469 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,15309447 0,17826968 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,15309447 0,17818475 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,15309447 0,1780999 ! primary neural tube formation GO:0014020 61 29 0,000 0,15309447 0,17801513 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,15309447 0,17793044 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,15309447 0,17784583 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,15309447 0,1777613 ! synaptogenesis GO:0007416 46 29 0,000 0,15309447 0,17767686 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,15309447 0,17759249 ! phenol metabolic process GO:0018958 56 30 0,000 0,15793529 0,18312098 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,15793529 0,18303411 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,15793529 0,18294733 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,15793529 0,18286062 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,15793529 0,182774 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,15793529 0,18268746 ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,15793529 0,182601 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,15793529 0,18251462 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,15793529 0,18242833 ! cell fate determination GO:0001709 64 30 0,000 0,15793529 0,18234211 ! phospholipid transport GO:0015914 65 30 0,000 0,15793529 0,18225598 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,15793529 0,18216993 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,15793529 0,18208396 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,15793529 0,18199807 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,15793529 0,18191226 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,15793529 0,18182654 GO:0048871|multicellular organismal homeostasis, ! alkaloid metabolic process GO:0009820 57 31 0,000 0,16274858 0,18727969 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,16274858 0,18719151 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,16274858 0,18710342 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,16274858 0,18701542 ! regulation of innate immune response GO:0045088 57 31 0,000 0,16274858 0,18692749 ! ovulation cycle process GO:0022602 55 31 0,000 0,16274858 0,18683965 ! peptide transport GO:0015833 60 31 0,000 0,16274858 0,18675189 ! male gonad development GO:0008584 56 31 0,000 0,16274858 0,18666421 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,16274858 0,18657662 ! detection of light stimulus GO:0009583 44 31 0,000 0,16274858 0,18648911 ! natural killer cell activation GO:0030101 50 31 0,000 0,16274858 0,18640168 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,16274858 0,18631433 ! eye morphogenesis GO:0048592 65 31 0,000 0,16274858 0,18622706 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,16274858 0,18613988 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,16753449 0,19152399 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,16753449 0,1914344 ! collagen metabolic process GO:0032963 49 32 0,000 0,16753449 0,19134491 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,16753449 0,19125549 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,16753449 0,19116616 ! metanephros development GO:0001656 81 32 0,000 0,16753449 0,19107692 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,16753449 0,19098775 ! mesoderm formation GO:0001707 73 32 0,000 0,16753449 0,19089867 ! ovulation cycle GO:0042698 57 32 0,000 0,16753449 0,19080968 ! hindbrain development GO:0030902 65 32 0,000 0,16753449 0,19072076 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,16753449 0,19063193 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,16753449 0,19054318 ! gene silencing GO:0016458 71 32 0,000 0,16753449 0,19045452 ! regulation of pH GO:0006885 56 33 0,000 0,17229318 0,19577313 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,17229318 0,19568211 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,17229318 0,19559118 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,17229318 0,19550034 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,17229318 0,19540958 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,17229318 0,1953189 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,17229318 0,19522831 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,17229318 0,1951378 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,17229318 0,19504737 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,17229318 0,19495703 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,17229318 0,19486677 ! glial cell differentiation GO:0010001 67 34 0,000 0,17702479 0,20012567 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,17702479 0,2000331 ! cholesterol transport GO:0030301 62 34 0,000 0,17702479 0,19994062 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,17702479 0,19984823 ! spliceosome assembly GO:0000245 75 34 0,000 0,17702479 0,19975592 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,17702479 0,1996637 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,17702479 0,19957156 ! formation of primary germ layer GO:0001704 76 34 0,000 0,17702479 0,19947951 ! cell fate specification GO:0001708 56 34 0,000 0,17702479 0,19938754 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,17702479 0,19929566 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,17702479 0,19920386 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,1817295 0,20440385 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,1817295 0,20430978 ! negative regulation of secretion GO:0051048 68 35 0,000 0,1817295 0,2042158 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,1817295 0,20412191 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,1817295 0,20402811 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,1817295 0,20393439 ! membrane docking GO:0022406 69 35 0,000 0,1817295 0,20384075 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,1817295 0,2037472 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,1817295 0,20365374 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,1817295 0,20356037 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,1817295 0,20346708 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,1817295 0,20337387 ! sterol transport GO:0015918 63 35 0,000 0,1817295 0,20328075 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,1817295 0,20318772 ! vesicle localization GO:0051648 70 35 0,000 0,1817295 0,20309477 ! regulation of muscle development GO:0048634 82 36 0,000 0,18640743 0,20822742 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,18640743 0,20813225 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,18640743 0,20803717 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,18640743 0,20794217 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,18640743 0,20784727 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,18640743 0,20775245 ! positive regulation of cell development GO:0010720 85 36 0,000 0,18640743 0,20765771 ! protein targeting to membrane GO:0006612 75 36 0,000 0,18640743 0,20756306 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,18640743 0,2074685 ! cytokine production GO:0001816 68 36 0,000 0,18640743 0,20737403 ! embryonic organ development GO:0048568 67 36 0,000 0,18640743 0,20727964 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,18640743 0,20718533 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,19105876 0,21225855 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,19105876 0,21216207 ! sister chromatid segregation GO:0000819 65 37 0,000 0,19105876 0,21206568 ! odontogenesis GO:0042476 74 37 0,000 0,19105876 0,21196937 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,19105876 0,21187315 ! female gonad development GO:0008585 71 37 0,000 0,19105876 0,21177702 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,19105876 0,21168098 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,19568363 0,21670675 ! meiosis I GO:0007127 74 38 0,000 0,19568363 0,21660856 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,19568363 0,21651046 ! organic anion transport GO:0015711 82 38 0,000 0,19568363 0,21641245 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,19568363 0,21631452 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,19568363 0,21621669 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,19568363 0,21611894 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,19568363 0,21602128 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,19568363 0,21592371 ! regulation of protein stability GO:0031647 77 38 0,000 0,19568363 0,21582623 ! spermatid development GO:0007286 69 38 0,000 0,19568363 0,21572883 ! pigment metabolic process GO:0042440 87 38 0,000 0,19568363 0,21563153 ! neural tube formation GO:0001841 79 38 0,000 0,19568363 0,21553431 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,20028218 0,22049994 ! negative regulation of binding GO:0051100 71 39 0,000 0,20028218 0,22040061 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,20028218 0,22030138 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,20028218 0,22020223 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,20028218 0,22010318 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,20028218 0,22000421 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,20028218 0,21990533 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,20028218 0,21980654 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,20485457 0,22472371 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,20485457 0,22462285 ! learning GO:0007612 82 40 0,000 0,20485457 0,22452208 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,20485457 0,22442139 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,20485457 0,2243208 ! mismatch repair GO:0006298 58 40 0,000 0,20485457 0,2242203 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,20485457 0,22411989 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,20485457 0,22401957 ! RNA export from nucleus GO:0006405 61 41 0,000 0,20940094 0,22888882 ! mRNA catabolic process GO:0006402 79 41 0,000 0,20940094 0,22878645 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,20940094 0,22868418 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,20940094 0,228582 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,20940094 0,2284799 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,20940094 0,2283779 ! gliogenesis GO:0042063 91 41 0,000 0,20940094 0,228276 ! feeding behavior GO:0007631 69 41 0,000 0,20940094 0,22817418 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,20940094 0,22807245 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,20940094 0,22797081 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,20940094 0,22786927 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,20940094 0,22776781 ! spermatid differentiation GO:0048515 73 41 0,000 0,20940094 0,22766645 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,20940094 0,22756517 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,21392145 0,23237444 ! organic ether metabolic process GO:0018904 59 42 0,000 0,21392145 0,23227116 ! T cell differentiation GO:0030217 93 42 0,000 0,21392145 0,23216797 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,21392145 0,23206488 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,21392145 0,23196188 ! regulation of protein secretion GO:0050708 77 42 0,000 0,21392145 0,23185897 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,21392145 0,23175615 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,21392145 0,23165342 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,21841624 0,23641598 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,21841624 0,23631128 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,21841624 0,23620667 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,21841624 0,23610216 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,21841624 0,23599773 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,21841624 0,2358934 ! ion transmembrane transport GO:0034220 79 43 0,000 0,21841624 0,23578916 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,22288545 0,24050758 ! striated muscle contraction GO:0006941 85 44 0,000 0,22288545 0,2404014 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,22732923 0,2450862 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,22732923 0,24497808 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! biopolymer methylation GO:0043414 91 45 0,000 0,22732923 0,24487007 ! B cell differentiation GO:0030183 124 45 0,000 0,22732923 0,24476215 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,22732923 0,24465433 ! female gamete generation GO:0007292 71 45 0,000 0,22732923 0,2445466 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,22732923 0,24443896 ! maintenance of location in cell GO:0051651 101 45 0,000 0,22732923 0,24433142 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,23174773 0,24897085 ! glycolysis GO:0006096 71 46 0,000 0,23174773 0,24886141 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,23174773 0,24875207 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,23174773 0,24864282 ! neural tube development GO:0021915 91 47 0,000 0,23614108 0,25324524 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,24050943 0,25781682 ! mitochondrial transport GO:0006839 94 48 0,000 0,24050943 0,25770375 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,24050943 0,25759077 ! endosome transport GO:0016197 127 48 0,000 0,24050943 0,25747789 ! male sex differentiation GO:0046661 93 48 0,000 0,24050943 0,25736511 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,24050943 0,25725243 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,24050943 0,25713984 ! methylation GO:0032259 97 48 0,000 0,24050943 0,25702736 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,24485292 0,26155474 ! JNK cascade GO:0007254 106 49 0,000 0,24485292 0,26144043 ! protein homooligomerization GO:0051260 84 49 0,000 0,24485292 0,26132621 ! regulation of ion transport GO:0043269 86 50 0,000 0,2491717 0,26581941 ! endocrine system development GO:0035270 109 50 0,000 0,2491717 0,26570339 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,2491717 0,26558746 ! regulation of ossification GO:0030278 123 50 0,000 0,2491717 0,26547163 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,2491717 0,26535591 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,2491717 0,26524029 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,2491717 0,26512476 ! viral infectious cycle GO:0019058 104 51 0,000 0,25346589 0,26957648 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,25346589 0,26945917 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,25773565 0,27387916 ! Notch signaling pathway GO:0007219 111 52 0,000 0,25773565 0,27376008 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,25773565 0,27364111 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,25773565 0,27352224 ! excretion GO:0007588 87 52 0,000 0,25773565 0,27340347 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,25773565 0,2732848 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,25773565 0,27316624 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,25773565 0,27304778 ! inner ear development GO:0048839 89 53 0,000 0,2619811 0,27742515 ! chromatin remodeling GO:0006338 122 53 0,000 0,2619811 0,27730495 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,2619811 0,27718486 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,2619811 0,27706486 ! vesicle organization GO:0016050 127 53 0,000 0,2619811 0,27694497 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,26620239 0,28128566 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,26620239 0,28116405 ! membrane fusion GO:0006944 122 54 0,000 0,26620239 0,28104254 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,26620239 0,28092114 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,26620239 0,28079985 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,26620239 0,28067866 ! RNA catabolic process GO:0006401 103 55 0,000 0,27039966 0,28498117 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,27039966 0,28485828 ! cell maturation GO:0048469 107 55 0,000 0,27039966 0,2847355 ! glucose catabolic process GO:0006007 88 56 0,000 0,27457303 0,28900556 ! regulation of DNA replication GO:0006275 105 56 0,000 0,27457303 0,2888811 ! RNA elongation GO:0006354 90 56 0,000 0,27457303 0,28875674 ! chloride transport GO:0006821 102 57 0,000 0,27872265 0,29299459 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,27872265 0,29286857 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,28284865 0,2970762 ! gastrulation GO:0007369 122 58 0,000 0,28284865 0,29694854 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,28284865 0,29682098 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,28284865 0,29669354 ! maintenance of location GO:0051235 124 58 0,000 0,28284865 0,2965662 ! nuclear export GO:0051168 110 59 0,000 0,28695116 0,3007386 ! establishment of organelle localization GO:0051656 122 59 0,000 0,28695116 0,30060964 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,29103032 0,30475228 ! regulation of endocytosis GO:0030100 104 60 0,000 0,29103032 0,30462171 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,29103032 0,30449125 ! kidney development GO:0001822 133 60 0,000 0,29103032 0,3043609 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,29508625 0,30847057 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,29508625 0,30833863 ! camera-type eye development GO:0043010 126 61 0,000 0,29508625 0,30820681 ! proton transport GO:0015992 117 61 0,000 0,29508625 0,30807509 ! viral reproductive process GO:0022415 132 62 0,000 0,2991191 0,31215206 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,2991191 0,31201877 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,2991191 0,3118856 ! tRNA processing GO:0008033 102 62 0,000 0,2991191 0,31175254 ! regulation of mitosis GO:0007088 112 63 0,000 0,30312899 0,31579706 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,30312899 0,31566245 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,30312899 0,31552796 ! hydrogen transport GO:0006818 121 64 0,000 0,30711605 0,31954195 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,30711605 0,31940592 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,3110804 0,32339125 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,3110804 0,32325369 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,31502219 0,32721055 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,31502219 0,32707149 ! gonad development GO:0008406 115 66 0,000 0,31502219 0,32693255 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,31894154 0,33085952 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,31894154 0,33071909 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,31894154 0,33057878 ! secondary metabolic process GO:0019748 125 67 0,000 0,31894154 0,33043858 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,31894154 0,33029851 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,32283856 0,33419263 ! hexose catabolic process GO:0019320 113 68 0,000 0,32283856 0,33405109 ! extracellular matrix organization GO:0030198 146 68 0,000 0,32283856 0,33390966 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,32283856 0,33376835 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,32283856 0,33362716 ! viral reproduction GO:0016032 142 68 0,000 0,32283856 0,33348609 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,3267134 0,33734609 ! urogenital system development GO:0001655 149 69 0,000 0,3267134 0,33720357 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,3267134 0,33706117 ! single fertilization GO:0007338 83 69 0,000 0,3267134 0,33691889 ! activation of immune response GO:0002253 120 70 0,000 0,33056618 0,34074817 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,33056618 0,34060446 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,33439701 0,34440637 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,33439701 0,34426123 ! appendage morphogenesis GO:0035107 150 72 0,000 0,33820603 0,34803595 GO:0035108|limb morphogenesis, ! B cell activation GO:0042113 179 72 0,000 0,33820603 0,34788941 ! appendage development GO:0048736 151 73 0,000 0,34199336 0,35163712 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,34199336 0,35148918 ! regulation of immune effector process GO:0002697 156 73 0,000 0,34199336 0,35134138 ! amino acid transport GO:0006865 148 74 0,000 0,34575913 0,35506076 ! organelle localization GO:0051640 155 74 0,000 0,34575913 0,35491157 ! reproductive structure development GO:0048608 131 75 0,000 0,34950344 0,35860433 ! eye development GO:0001654 155 75 0,000 0,34950344 0,35845378 ! rhythmic process GO:0048511 142 75 0,000 0,34950344 0,35830336 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,35322643 0,3619682 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,35322643 0,36181643 ! amine catabolic process GO:0009310 136 77 0,000 0,35692822 0,36545501 ! neurotransmitter transport GO:0006836 142 77 0,000 0,35692822 0,36530191 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,35692822 0,36514893 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,35692822 0,36499609 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,35692822 0,36484337 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,36060893 0,36845153 ! antigen processing and presentation GO:0019882 117 78 0,000 0,36060893 0,3682975 ! fertilization GO:0009566 99 78 0,000 0,36060893 0,36814359 ! blood coagulation GO:0007596 151 79 0,000 0,36426867 0,37172446 GO:0050817|coagulation, ! protein oligomerization GO:0051259 149 79 0,000 0,36426867 0,37156925 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,36426867 0,37141417 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,36790757 0,37496795 ! meiosis GO:0007126 143 81 0,000 0,37152574 0,37849765 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,37152574 0,37833988 ! meiotic cell cycle GO:0051321 144 82 0,000 0,3751233 0,38184426 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,37870036 0,38532486 ! response to drug GO:0042493 149 83 0,000 0,37870036 0,38516444 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,37870036 0,38500416 ! T cell activation GO:0042110 189 84 0,000 0,38225705 0,3884584 ! response to nutrient GO:0007584 135 84 0,000 0,38225705 0,38829688 ! digestion GO:0007586 130 84 0,000 0,38225705 0,38813549 ! hemostasis GO:0007599 165 85 0,000 0,38579349 0,39156356 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,38579349 0,39140095 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,38579349 0,39123847 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,38579349 0,39107613 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,38930977 0,39447688 ! regulation of lyase activity GO:0051339 169 86 0,000 0,38930977 0,39431334 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,39280602 0,39768964 ! nucleosome assembly GO:0006334 126 87 0,000 0,39280602 0,3975249 ! amine biosynthetic process GO:0009309 146 88 0,000 0,39628236 0,40087693 ! sensory perception of smell GO:0007608 117 88 0,000 0,39628236 0,40071101 ! chromatin assembly GO:0031497 128 88 0,000 0,39628236 0,40054522 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,39628236 0,40037957 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,39973888 0,40370488 ! cellular defense response GO:0006968 123 89 0,000 0,39973888 0,40353806 ! regulation of neurological system process GO:0031644 175 89 0,000 0,39973888 0,40337137 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,40317572 0,40667146 ! response to unfolded protein GO:0006986 139 90 0,000 0,40317572 0,40650363 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,40317572 0,40633593 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,40659297 0,40961098 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,40999076 0,41286374 ! amine transport GO:0015837 181 93 0,000 0,41336918 0,41609432 ! vitamin metabolic process GO:0006766 153 93 0,000 0,41336918 0,41592295 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,41672836 0,41913025 ! female pregnancy GO:0007565 166 94 0,000 0,41672836 0,41895777 ! sterol metabolic process GO:0016125 166 94 0,000 0,41672836 0,41878543 ! nucleosome organization GO:0034728 143 95 0,000 0,42006839 0,42196837 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,42006839 0,42179493 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,42006839 0,42162164 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,42006839 0,42144849 ! sex differentiation GO:0007548 171 96 0,000 0,42338939 0,42460602 ! response to protein stimulus GO:0051789 158 96 0,000 0,42338939 0,42443179 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,42669146 0,42756655 ! leukocyte differentiation GO:0002521 232 98 0,000 0,42997472 0,43067989 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,42997472 0,43050338 ! mRNA transport GO:0051028 185 100 0,000 0,43648521 0,43684284 ! positive regulation of immune response GO:0050778 175 100 0,000 0,43648521 0,43666395 ! hormone metabolic process GO:0042445 171 100 0,000 0,43648521 0,43648521