pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6853-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 3,000 3,208E-08 7,378E-05 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 6,000 5,994E-08 6,893E-05 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 3,000 1,145E-07 8,778E-05 ! positive regulation of phosphorylation GO:0042327 102 70 6,000 1,258E-07 7,233E-05 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 6,000 1,532E-07 7,046E-05 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of mast cell proliferation GO:0070666 64 44 5,000 1,58E-07 6,056E-05 ! regulation of leukocyte proliferation GO:0070663 71 47 5,000 2,371E-07 7,79E-05 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of T cell activation GO:0050863 128 89 6,000 6,63E-07 1,906E-04 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 1,209E-06 3,089E-04 ! positive regulation of leukocyte proliferation GO:0070665 50 35 4,000 1,419E-06 3,264E-04 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 5,000 1,533E-06 3,206E-04 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 2,000 1,694E-06 3,248E-04 GO:0033135|regulation of peptidyl-serine phosphorylation, ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 2,000 1,694E-06 2,998E-04 GO:0022011|myelination in the peripheral nervous system, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 4,000 1,888E-06 3,102E-04 ! regulation of T cell proliferation GO:0042129 58 38 4,000 2,165E-06 3,32E-04 ! positive regulation of translation GO:0045727 28 18 3,000 2,675E-06 3,845E-04 ! regulation of T cell differentiation GO:0045580 59 41 4,000 3,19E-06 4,315E-04 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 3,374E-06 4,311E-04 ! male meiosis GO:0007140 7 6 2,000 3,375E-06 4,086E-04 ! Schwann cell development GO:0014044 14 6 2,000 3,375E-06 3,881E-04 ! regulation of JAK-STAT cascade GO:0046425 61 42 4,000 3,605E-06 3,948E-04 ! positive regulation of lymphocyte activation GO:0051251 108 74 5,000 3,621E-06 3,786E-04 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 4,000 4,061E-06 4,061E-04 ! positive regulation of B cell activation GO:0050871 31 20 3,000 4,199E-06 4,024E-04 ! positive regulation of protein modification process GO:0031401 107 78 5,000 4,931E-06 4,536E-04 ! regulation of adaptive immune response GO:0002819 72 46 4,000 5,706E-06 5,048E-04 ! positive regulation of cell activation GO:0050867 120 81 5,000 6,147E-06 5,236E-04 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 4,000 7,065E-06 5,804E-04 ! regulation of lymphocyte differentiation GO:0045619 69 48 4,000 7,065E-06 5,604E-04 ! myelination GO:0042552 35 23 3,000 7,576E-06 5,808E-04 ! positive regulation of MAP kinase activity GO:0043406 121 85 5,000 8,135E-06 6,036E-04 ! positive regulation of B cell proliferation GO:0030890 11 8 2,000 9,373E-06 6,737E-04 ! Schwann cell differentiation GO:0014037 17 8 2,000 9,373E-06 6,533E-04 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 9,373E-06 6,341E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 9,373E-06 6,16E-04 ! myeloid cell homeostasis GO:0002262 8 8 2,000 9,373E-06 5,988E-04 ! positive regulation of MAPKKK cascade GO:0043410 36 25 3,000 1,073E-05 6,67E-04 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 3,000 1,714E-05 1,038E-03 ! ensheathment of neurons GO:0007272 43 28 3,000 1,714E-05 1,011E-03 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 3,000 1,714E-05 9,858E-04 ! positive regulation of T cell proliferation GO:0042102 44 29 3,000 1,98E-05 1,111E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 1,992E-05 1,091E-03 ! negative regulation of lipid metabolic process GO:0045833 14 10 2,000 1,992E-05 1,066E-03 ! regulation of chemokine biosynthetic process GO:0045073 12 10 2,000 1,992E-05 1,041E-03 ! positive regulation of interleukin-6 production GO:0032755 13 10 2,000 1,992E-05 1,018E-03 ! negative regulation of secretion GO:0051048 49 31 3,000 2,601E-05 1,3E-03 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 2,000 2,728E-05 1,335E-03 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 2,000 2,728E-05 1,307E-03 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 3,000 2,96E-05 1,389E-03 ! peripheral nervous system development GO:0007422 53 32 3,000 2,96E-05 1,361E-03 ! regulation of MAPKKK cascade GO:0043408 101 65 4,000 3,161E-05 1,426E-03 ! positive regulation of T cell activation GO:0050870 94 65 4,000 3,161E-05 1,398E-03 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 2,000 3,623E-05 1,572E-03 ! Golgi organization GO:0007030 18 12 2,000 3,623E-05 1,543E-03 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 3,000 3,784E-05 1,583E-03 ! regulation of action potential in neuron GO:0019228 54 35 3,000 4,254E-05 1,747E-03 ! regulation of chemokine production GO:0032642 17 13 2,000 4,69E-05 1,893E-03 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 2,000 4,69E-05 1,86E-03 ! positive regulation of transcription factor activity GO:0051091 49 36 3,000 4,766E-05 1,858E-03 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 3,000 4,766E-05 1,827E-03 ! negative regulation of transport GO:0051051 116 73 4,000 5,549E-05 2,092E-03 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 2,000 5,945E-05 2,206E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 6,569E-05 2,398E-03 ! regulation of DNA binding GO:0051101 119 77 4,000 7,171E-05 2,577E-03 ! gland development GO:0048732 148 77 4,000 7,171E-05 2,537E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 7,268E-05 2,533E-03 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 2,000 7,402E-05 2,541E-03 ! regulation of T-helper cell differentiation GO:0045622 23 15 2,000 7,402E-05 2,503E-03 ! positive regulation of DNA binding GO:0043388 57 41 3,000 8,019E-05 2,673E-03 ! glial cell development GO:0021782 24 16 2,000 9,073E-05 2,981E-03 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 2,000 9,073E-05 2,939E-03 ! positive regulation of binding GO:0051099 59 43 3,000 9,689E-05 3,095E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 9,689E-05 3,053E-03 ! regulation of action potential GO:0001508 71 44 3,000 1,061E-04 3,298E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1,097E-04 3,365E-03 ! regulation of immunoglobulin production GO:0002637 25 17 2,000 1,097E-04 3,32E-03 ! response to UV GO:0009411 75 46 3,000 1,265E-04 3,778E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 1,311E-04 3,867E-03 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 2,000 1,311E-04 3,818E-03 ! positive regulation of cytokine production GO:0001819 73 48 3,000 1,495E-04 4,299E-03 ! regulation of interleukin-6 production GO:0032675 22 19 2,000 1,551E-04 4,404E-03 ! regulation of interleukin-2 production GO:0032663 31 19 2,000 1,551E-04 4,35E-03 ! regulation of angiogenesis GO:0045765 94 49 3,000 1,621E-04 4,493E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,817E-04 4,975E-03 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 2,000 1,817E-04 4,917E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 1,896E-04 5,07E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,896E-04 5,012E-03 ! regulation of binding GO:0051098 151 95 4,000 1,942E-04 5,077E-03 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 2,000 2,111E-04 5,456E-03 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 2,000 2,111E-04 5,396E-03 ! cytokine-mediated signaling pathway GO:0019221 76 54 3,000 2,369E-04 5,987E-03 ! viral genome replication GO:0019079 29 22 2,000 2,435E-04 6,087E-03 ! leukocyte homeostasis GO:0001776 33 22 2,000 2,435E-04 6,021E-03 ! regulation of translation GO:0006417 151 100 4,000 2,469E-04 6,041E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 2,727E-04 6,603E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 2,727E-04 6,534E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 2,000 2,789E-04 6,612E-03 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 2,789E-04 6,545E-03 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 2,789E-04 6,479E-03 ! response to molecule of bacterial origin GO:0002237 30 23 2,000 2,789E-04 6,414E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 2,921E-04 6,651E-03 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 1,000 3,077E-04 6,937E-03 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! regulation of collagen biosynthetic process GO:0032965 6 5 1,000 3,077E-04 6,87E-03 ! neurofilament cytoskeleton organization GO:0060052 8 5 1,000 3,077E-04 6,804E-03 ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 3,077E-04 6,739E-03 ! response to protozoan GO:0001562 9 5 1,000 3,077E-04 6,676E-03 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 1,000 3,077E-04 6,613E-03 ! neutrophil mediated immunity GO:0002446 6 5 1,000 3,077E-04 6,552E-03 ! microvillus organization GO:0032528 7 5 1,000 3,077E-04 6,492E-03 GO:0030033|microvillus assembly, ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 1,000 3,077E-04 6,433E-03 ! response to ATP GO:0033198 6 5 1,000 3,077E-04 6,375E-03 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 1,000 3,077E-04 6,318E-03 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 3,077E-04 6,262E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 3,077E-04 6,207E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 3,077E-04 6,153E-03 ! negative regulation of smooth muscle contraction GO:0045986 9 5 1,000 3,077E-04 6,1E-03 ! organ regeneration GO:0031100 7 5 1,000 3,077E-04 6,048E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 3,124E-04 6,088E-03 ! regulation of cytokine biosynthetic process GO:0042035 76 58 3,000 3,124E-04 6,037E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 3,174E-04 6,084E-03 ! regulation of alpha-beta T cell activation GO:0046634 35 24 2,000 3,174E-04 6,033E-03 ! activation of MAPK activity GO:0000187 84 59 3,000 3,337E-04 6,29E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 3,592E-04 6,717E-03 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of transferase activity GO:0051348 105 61 3,000 3,793E-04 7,036E-03 ! regulation of transcription factor activity GO:0051090 97 63 3,000 4,293E-04 7,899E-03 GO:0090046|regulation of transcription regulator activity, ! acute-phase response GO:0006953 42 27 2,000 4,531E-04 8,272E-03 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 2,000 4,531E-04 8,207E-03 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 1,000 4,598E-04 8,262E-03 GO:0045346|regulation of MHC class II biosynthetic process, ! regulation of lipid catabolic process GO:0050994 9 6 1,000 4,598E-04 8,198E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 4,598E-04 8,135E-03 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 1,000 4,598E-04 8,073E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 4,598E-04 8,012E-03 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 1,000 4,598E-04 7,951E-03 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 4,598E-04 7,892E-03 ! regulation of collagen metabolic process GO:0010712 7 6 1,000 4,598E-04 7,834E-03 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 1,000 4,598E-04 7,776E-03 ! astrocyte development GO:0014002 14 6 1,000 4,598E-04 7,719E-03 ! response to copper ion GO:0046688 9 6 1,000 4,598E-04 7,663E-03 ! neutrophil homeostasis GO:0001780 6 6 1,000 4,598E-04 7,608E-03 ! salivary gland morphogenesis GO:0007435 11 6 1,000 4,598E-04 7,554E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 4,598E-04 7,5E-03 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 1,000 4,598E-04 7,447E-03 GO:0045625|regulation of T-helper 1 cell differentiation, ! removal of superoxide radicals GO:0019430 10 6 1,000 4,598E-04 7,395E-03 ! organ or tissue specific immune response GO:0002251 7 6 1,000 4,598E-04 7,344E-03 ! positive regulation of T cell differentiation GO:0045582 39 28 2,000 5,055E-04 8,018E-03 ! regulation of immune effector process GO:0002697 101 66 3,000 5,128E-04 8,078E-03 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 5,615E-04 8,785E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 6,414E-04 9,967E-03 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 1,000 6,414E-04 9,9E-03 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 6,414E-04 9,834E-03 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 6,414E-04 9,769E-03 ! cerebral cortex cell migration GO:0021795 11 7 1,000 6,414E-04 9,705E-03 ! positive regulation of isotype switching GO:0045830 15 7 1,000 6,414E-04 9,641E-03 GO:0045911|positive regulation of DNA recombination, ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 1,000 6,414E-04 9,579E-03 ! positive regulation of activated T cell proliferation GO:0042104 12 7 1,000 6,414E-04 9,517E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 6,414E-04 9,456E-03 ! negative regulation of muscle contraction GO:0045932 12 7 1,000 6,414E-04 9,396E-03 ! negative regulation of osteoclast differentiation GO:0045671 10 7 1,000 6,414E-04 9,336E-03 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 6,414E-04 9,278E-03 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 1,000 6,414E-04 9,22E-03 ! muscle adaptation GO:0043500 12 7 1,000 6,414E-04 9,162E-03 ! retina homeostasis GO:0001895 9 7 1,000 6,414E-04 9,106E-03 ! defense response to Gram-negative bacterium GO:0050829 9 7 1,000 6,414E-04 9,05E-03 ! mammary gland development GO:0030879 57 31 2,000 6,851E-04 9,609E-03 ! glial cell differentiation GO:0010001 55 31 2,000 6,851E-04 9,551E-03 ! leukocyte chemotaxis GO:0030595 43 31 2,000 6,851E-04 9,493E-03 GO:0060326|cell chemotaxis, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 2,000 7,53E-04 0,01037015 ! cytokine production GO:0001816 44 32 2,000 7,53E-04 0,01030842 ! regulation of proteolysis GO:0030162 50 33 2,000 8,249E-04 0,01122652 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 8,52E-04 0,01152734 ! cell proliferation in forebrain GO:0021846 10 8 1,000 8,52E-04 0,01145993 ! keratinocyte proliferation GO:0043616 12 8 1,000 8,52E-04 0,01139331 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 8,52E-04 0,01132745 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 8,52E-04 0,01126235 ! astrocyte differentiation GO:0048708 16 8 1,000 8,52E-04 0,01119799 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 1,000 8,52E-04 0,01113437 ! lens development in camera-type eye GO:0002088 10 8 1,000 8,52E-04 0,01107146 ! regulation of smoothened signaling pathway GO:0008589 13 8 1,000 8,52E-04 0,01100926 ! copper ion homeostasis GO:0055070 10 8 1,000 8,52E-04 0,01094776 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 8,52E-04 0,01088694 ! peptidyl-asparagine modification GO:0018196 13 8 1,000 8,52E-04 0,01082679 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 8,52E-04 0,0107673 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 1,000 8,52E-04 0,01070846 ! regulation of T-helper 1 type immune response GO:0002825 9 8 1,000 8,52E-04 0,01065026 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 8,52E-04 0,0105927 ! regulation of protein transport GO:0051223 114 76 3,000 8,746E-04 0,01081537 GO:0070201|regulation of establishment of protein localization, ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 9,011E-04 0,01108271 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 9,011E-04 0,01102376 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 9,816E-04 0,01194491 ! protein homooligomerization GO:0051260 52 35 2,000 9,816E-04 0,01188204 ! telencephalon cell migration GO:0022029 16 9 1,000 1,091E-03 0,01314317 ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 1,091E-03 0,01307472 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 1,091E-03 0,01300698 ! myeloid leukocyte mediated immunity GO:0002444 11 9 1,000 1,091E-03 0,01293993 ! motor axon guidance GO:0008045 14 9 1,000 1,091E-03 0,01287357 ! thymus development GO:0048538 15 9 1,000 1,091E-03 0,01280789 ! detection of calcium ion GO:0005513 13 9 1,000 1,091E-03 0,01274288 ! defense response to Gram-positive bacterium GO:0050830 10 9 1,000 1,091E-03 0,01267852 ! localization within membrane GO:0051668 15 9 1,000 1,091E-03 0,01261481 ! gliogenesis GO:0042063 71 38 2,000 1,25E-03 0,01437343 ! regulation of protein localization GO:0032880 132 85 3,000 1,328E-03 0,01520007 ! regulation of membrane potential GO:0042391 128 85 3,000 1,328E-03 0,01512482 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 2,000 1,349E-03 0,01527908 ! JNK cascade GO:0007254 54 39 2,000 1,349E-03 0,01520418 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,359E-03 0,01525111 ! positive regulation of lipid metabolic process GO:0045834 12 10 1,000 1,359E-03 0,01517708 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,359E-03 0,01510376 ! forebrain cell migration GO:0021885 17 10 1,000 1,359E-03 0,01503114 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 1,359E-03 0,01495922 ! regulation of organ growth GO:0046620 11 10 1,000 1,359E-03 0,01488799 ! cranial nerve development GO:0021545 12 10 1,000 1,359E-03 0,01481743 ! salivary gland development GO:0007431 22 10 1,000 1,359E-03 0,01474754 ! positive regulation of acute inflammatory response GO:0002675 14 10 1,000 1,359E-03 0,0146783 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,359E-03 0,01460971 ! positive regulation of JNK cascade GO:0046330 14 10 1,000 1,359E-03 0,01454176 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 1,359E-03 0,01447443 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 1,387E-03 0,01470331 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 2,000 1,452E-03 0,01531919 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 1,452E-03 0,01524924 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,452E-03 0,01517993 ! interphase GO:0051325 159 88 3,000 1,51E-03 0,01571903 ! regulation of leukocyte mediated immunity GO:0002703 62 41 2,000 1,56E-03 0,0161652 ! regulation of JNK cascade GO:0046328 58 41 2,000 1,56E-03 0,01609271 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,655E-03 0,0169969 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 1,655E-03 0,01692136 ! negative regulation of proteolysis GO:0045861 16 11 1,000 1,655E-03 0,01684649 ! plasma membrane organization GO:0007009 18 11 1,000 1,655E-03 0,01677227 ! temperature homeostasis GO:0001659 16 11 1,000 1,655E-03 0,01669871 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 1,000 1,655E-03 0,01662579 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 1,655E-03 0,01655351 ! regulation of isotype switching GO:0045191 19 11 1,000 1,655E-03 0,01648185 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,655E-03 0,0164108 ! regulation of osteoclast differentiation GO:0045670 15 11 1,000 1,655E-03 0,01634037 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 1,000 1,655E-03 0,01627054 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,655E-03 0,0162013 GO:0042130|negative regulation of T cell proliferation, ! regulation of steroid biosynthetic process GO:0050810 11 11 1,000 1,655E-03 0,01613265 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,674E-03 0,01624097 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 2,000 1,674E-03 0,01617273 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 2,000 1,674E-03 0,01610507 ! leukocyte migration GO:0050900 60 43 2,000 1,792E-03 0,01717117 ! response to insulin stimulus GO:0032868 63 43 2,000 1,792E-03 0,01709992 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 2,000 1,915E-03 0,0182015 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 1,979E-03 0,01873293 ! cytokine biosynthetic process GO:0042089 16 12 1,000 1,979E-03 0,01865616 ! auditory receptor cell differentiation GO:0042491 25 12 1,000 1,979E-03 0,01858001 ! positive regulation of cell growth GO:0030307 16 12 1,000 1,979E-03 0,01850448 ! cell-cell junction assembly GO:0007043 18 12 1,000 1,979E-03 0,01842957 ! histone acetylation GO:0016573 23 12 1,000 1,979E-03 0,01835525 ! autonomic nervous system development GO:0048483 23 12 1,000 1,979E-03 0,01828154 ! gland morphogenesis GO:0022612 23 12 1,000 1,979E-03 0,01820841 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,979E-03 0,01813587 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,044E-03 0,01865212 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 2,044E-03 0,0185784 ! response to light stimulus GO:0009416 153 96 3,000 2,08E-03 0,0188311 ! viral infectious cycle GO:0019058 71 47 2,000 2,316E-03 0,02089347 ! endocrine system development GO:0035270 83 47 2,000 2,316E-03 0,02081186 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,33E-03 0,02085659 ! copper ion transport GO:0006825 15 13 1,000 2,33E-03 0,02077575 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 2,33E-03 0,02069553 ! endocrine pancreas development GO:0031018 19 13 1,000 2,33E-03 0,02061594 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 2,33E-03 0,02053695 ! cytokine metabolic process GO:0042107 17 13 1,000 2,33E-03 0,02045856 ! exocrine system development GO:0035272 27 13 1,000 2,33E-03 0,02038077 ! regulation of exocytosis GO:0017157 17 13 1,000 2,33E-03 0,02030357 ! intermediate filament cytoskeleton organization GO:0045104 23 13 1,000 2,33E-03 0,02022696 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 2,33E-03 0,02015091 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 2,33E-03 0,02007544 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 2,33E-03 0,02000053 ! regulation of acute inflammatory response GO:0002673 19 13 1,000 2,33E-03 0,01992618 ! regulation of intracellular transport GO:0032386 78 49 2,000 2,611E-03 0,02224043 ! superoxide anion generation GO:0042554 18 14 1,000 2,709E-03 0,02299155 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 2,709E-03 0,02290702 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,709E-03 0,02282311 ! limbic system development GO:0021761 25 14 1,000 2,709E-03 0,02273982 ! pituitary gland development GO:0021983 23 14 1,000 2,709E-03 0,02265713 ! negative regulation of caspase activity GO:0043154 20 14 1,000 2,709E-03 0,02257504 ! embryo implantation GO:0007566 27 14 1,000 2,709E-03 0,02249354 ! intermediate filament-based process GO:0045103 24 14 1,000 2,709E-03 0,02241263 ! regulation of T-helper 2 type immune response GO:0002828 21 14 1,000 2,709E-03 0,02233229 ! muscle maintenance GO:0046716 19 14 1,000 2,709E-03 0,02225254 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 2,709E-03 0,02217334 ! peptide hormone secretion GO:0030072 23 14 1,000 2,709E-03 0,02209472 ! positive regulation of growth GO:0045927 67 50 2,000 2,766E-03 0,02248215 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 2,766E-03 0,02240299 ! regulation of protein catabolic process GO:0042176 77 51 2,000 2,927E-03 0,02362403 ! positive regulation of cell size GO:0045793 20 15 1,000 3,114E-03 0,02504577 ! skin development GO:0043588 25 15 1,000 3,114E-03 0,0249585 ! lipid phosphorylation GO:0046834 23 15 1,000 3,114E-03 0,02487184 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 3,114E-03 0,02478578 ! positive regulation of proteolysis GO:0045862 19 15 1,000 3,114E-03 0,02470031 ! cerebral cortex development GO:0021987 29 15 1,000 3,114E-03 0,02461543 ! peptide secretion GO:0002790 27 15 1,000 3,114E-03 0,02453113 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 3,114E-03 0,02444741 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 3,114E-03 0,02436425 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 3,114E-03 0,02428166 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 1,000 3,114E-03 0,02419963 ! regulation of mitosis GO:0007088 84 54 2,000 3,445E-03 0,02667587 GO:0051783|regulation of nuclear division, ! hormone secretion GO:0046879 25 16 1,000 3,546E-03 0,02737107 ! protein amino acid acetylation GO:0006473 28 16 1,000 3,546E-03 0,02727953 ! fructose metabolic process GO:0006000 20 16 1,000 3,546E-03 0,0271886 ! regulation of steroid metabolic process GO:0019218 21 16 1,000 3,546E-03 0,02709827 ! diencephalon development GO:0021536 25 16 1,000 3,546E-03 0,02700854 ! neutrophil chemotaxis GO:0030593 21 16 1,000 3,546E-03 0,0269194 ! nerve development GO:0021675 18 16 1,000 3,546E-03 0,02683085 ! inner ear receptor cell differentiation GO:0060113 30 16 1,000 3,546E-03 0,02674288 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 3,819E-03 0,02870253 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 4,005E-03 0,03000155 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 4,005E-03 0,02990414 ! neuromuscular junction development GO:0007528 23 17 1,000 4,005E-03 0,02980737 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 4,005E-03 0,02971121 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 4,005E-03 0,02961568 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of intracellular transport GO:0032387 29 17 1,000 4,005E-03 0,02952076 ! cell-cell junction organization GO:0045216 25 17 1,000 4,005E-03 0,02942644 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 4,015E-03 0,02940636 ! viral reproductive process GO:0022415 87 58 2,000 4,217E-03 0,03078749 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 4,489E-03 0,03267116 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 4,489E-03 0,0325681 ! axis specification GO:0009798 26 18 1,000 4,489E-03 0,03246568 ! mechanoreceptor differentiation GO:0042490 32 18 1,000 4,489E-03 0,03236391 ! pancreas development GO:0031016 26 18 1,000 4,489E-03 0,03226277 ! heart process GO:0003015 27 18 1,000 4,489E-03 0,03216226 GO:0060047|heart contraction, ! somitogenesis GO:0001756 24 18 1,000 4,489E-03 0,03206238 ! detection of chemical stimulus GO:0009593 26 18 1,000 4,489E-03 0,03196312 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 4,489E-03 0,03186446 ! hormone transport GO:0009914 27 18 1,000 4,489E-03 0,03176642 ! activation of JUN kinase activity GO:0007257 23 18 1,000 4,489E-03 0,03166898 ! negative regulation of T cell activation GO:0050868 25 18 1,000 4,489E-03 0,03157213 ! regulation of cellular response to stress GO:0080135 85 61 2,000 4,859E-03 0,03407233 ! meiosis GO:0007126 96 61 2,000 4,859E-03 0,03396876 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 2,000 4,859E-03 0,03386583 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 4,999E-03 0,0347333 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 4,999E-03 0,03462868 ! regeneration GO:0031099 32 19 1,000 4,999E-03 0,03452469 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 4,999E-03 0,03442132 ! apoptotic nuclear changes GO:0030262 24 19 1,000 4,999E-03 0,03431857 ! response to lipopolysaccharide GO:0032496 26 19 1,000 4,999E-03 0,03421643 ! vasodilation GO:0042311 33 19 1,000 4,999E-03 0,0341149 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 4,999E-03 0,03401397 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 4,999E-03 0,03391363 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 1,000 4,999E-03 0,03381389 ! meiotic cell cycle GO:0051321 97 62 2,000 5,086E-03 0,03430136 ! viral reproduction GO:0016032 92 63 2,000 5,318E-03 0,03576677 ! response to ethanol GO:0045471 37 20 1,000 5,534E-03 0,03710699 ! pallium development GO:0021543 38 20 1,000 5,534E-03 0,03699912 ! positive regulation of locomotion GO:0040017 35 20 1,000 5,534E-03 0,03689188 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 1,000 5,534E-03 0,03678526 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 5,534E-03 0,03667925 ! regulation of caspase activity GO:0043281 97 65 2,000 5,803E-03 0,03835317 ! protein oligomerization GO:0051259 100 65 2,000 5,803E-03 0,03824328 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 6,094E-03 0,04004669 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 6,094E-03 0,03993259 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 6,094E-03 0,03981915 ! protein amino acid acylation GO:0043543 37 21 1,000 6,094E-03 0,03970635 ! regulation of chemotaxis GO:0050920 36 21 1,000 6,094E-03 0,03959418 ! regulation of DNA recombination GO:0000018 40 21 1,000 6,094E-03 0,03948265 ! ovarian follicle development GO:0001541 30 21 1,000 6,094E-03 0,03937174 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 6,094E-03 0,03926146 ! cell aging GO:0007569 32 21 1,000 6,094E-03 0,03915179 ! regulation of insulin secretion GO:0050796 26 21 1,000 6,094E-03 0,03904273 ! platelet activation GO:0030168 28 21 1,000 6,094E-03 0,03893428 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 6,094E-03 0,03882643 ! positive regulation of protein secretion GO:0050714 26 21 1,000 6,094E-03 0,03871917 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 6,094E-03 0,03861251 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 6,094E-03 0,03850643 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 6,094E-03 0,03840093 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 6,313E-03 0,03967367 ! acute inflammatory response GO:0002526 92 68 2,000 6,578E-03 0,0412255 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 6,679E-03 0,0417445 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 6,679E-03 0,04163137 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 6,679E-03 0,04151885 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 6,679E-03 0,04140694 ! regulation of behavior GO:0050795 38 22 1,000 6,679E-03 0,04129563 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 6,679E-03 0,04118492 ! response to metal ion GO:0010038 103 70 2,000 7,128E-03 0,04383249 ! regulation of catabolic process GO:0009894 106 70 2,000 7,128E-03 0,0437156 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 7,289E-03 0,04458494 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 7,289E-03 0,04446668 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 7,289E-03 0,04434904 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 7,289E-03 0,04423202 ! hydrogen peroxide metabolic process GO:0042743 30 23 1,000 7,289E-03 0,04411562 ! negative regulation of catabolic process GO:0009895 34 23 1,000 7,289E-03 0,04399983 ! lymphocyte differentiation GO:0030098 113 71 2,000 7,412E-03 0,04462807 ! regulation of peptidase activity GO:0052547 106 72 2,000 7,703E-03 0,04626056 ! superoxide metabolic process GO:0006801 32 24 1,000 7,922E-03 0,04745199 ! fat cell differentiation GO:0045444 37 24 1,000 7,922E-03 0,04732874 ! negative regulation of cell development GO:0010721 56 24 1,000 7,922E-03 0,04720613 GO:0050768|negative regulation of neurogenesis, ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 7,922E-03 0,04708415 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 7,922E-03 0,0469628 ! glutathione metabolic process GO:0006749 29 24 1,000 7,922E-03 0,04684207 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 7,922E-03 0,04672196 ! neurotransmitter secretion GO:0007269 32 24 1,000 7,922E-03 0,04660247 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 7,922E-03 0,04648358 ! mitochondrion organization GO:0007005 104 73 2,000 8,001E-03 0,04682709 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 8,306E-03 0,04848668 ! peptide transport GO:0015833 43 25 1,000 8,58E-03 0,04996001 ! iron ion homeostasis GO:0055072 39 25 1,000 8,58E-03 0,04983385 ! regulation of peptide secretion GO:0002791 34 25 1,000 8,58E-03 0,04970832 ! positive regulation of nuclear division GO:0051785 39 25 1,000 8,58E-03 0,04958343 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 8,58E-03 0,04945916 ! response to inorganic substance GO:0010035 115 75 2,000 8,617E-03 0,04954999 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 9,261E-03 0,05312021 ! translational initiation GO:0006413 43 26 1,000 9,261E-03 0,05298807 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 9,261E-03 0,05285659 ! negative regulation of protein modification process GO:0031400 50 26 1,000 9,261E-03 0,05272575 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 9,261E-03 0,05259557 ! T cell activation GO:0042110 134 79 2,000 9,931E-03 0,05626041 ! inner ear morphogenesis GO:0042472 35 27 1,000 9,966E-03 0,05631922 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 9,966E-03 0,05618118 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 9,966E-03 0,05604382 ! negative regulation of protein transport GO:0051224 49 27 1,000 9,966E-03 0,05590713 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,01062938 0,05948314 ! cell junction assembly GO:0034329 56 28 1,000 0,01069379 0,05969835 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01069379 0,0595538 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01069379 0,05940995 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01069379 0,05926679 ! placenta development GO:0001890 37 28 1,000 0,01069379 0,05912433 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01144433 0,06312221 ! ovulation cycle process GO:0022602 41 29 1,000 0,01144433 0,0629712 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,01144433 0,06282091 ! telencephalon development GO:0021537 52 29 1,000 0,01144433 0,06267134 ! tissue homeostasis GO:0001894 42 29 1,000 0,01144433 0,06252248 GO:0048871|multicellular organismal homeostasis, ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,01210937 0,06599893 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,01210937 0,06584291 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,0122174 0,06627364 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,0122174 0,0661177 ! ovulation cycle GO:0042698 43 30 1,000 0,0122174 0,06596249 ! hindbrain development GO:0030902 45 30 1,000 0,0122174 0,06580801 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,0122174 0,06565426 ! response to heat GO:0009408 41 30 1,000 0,0122174 0,06550122 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,0122174 0,06534889 ! cell cycle arrest GO:0007050 150 86 2,000 0,01249692 0,06668888 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,01289152 0,06863543 GO:0060538|skeletal muscle organ development, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 1,000 0,01301273 0,06912073 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,01301273 0,06896146 ! segmentation GO:0035282 41 31 1,000 0,01301273 0,06880293 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,013702 0,07228117 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01383005 0,07278972 ! leukocyte differentiation GO:0002521 143 90 2,000 0,01411789 0,07413505 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,01466909 0,07685399 ! ear morphogenesis GO:0042471 42 33 1,000 0,01466909 0,07667932 ! cell junction organization GO:0034330 63 33 1,000 0,01466909 0,07650545 ! nucleus organization GO:0006997 49 33 1,000 0,01466909 0,07633236 ! female gonad development GO:0008585 49 33 1,000 0,01466909 0,07616005 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,01466909 0,07598852 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01466909 0,07581776 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01466909 0,07564776 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 0,01540841 0,07928266 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01552959 0,0797278 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,01552959 0,07955023 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 0,01552959 0,07937345 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,01552959 0,07919746 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,01552959 0,07902224 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,01641129 0,08332442 ! maintenance of protein location GO:0045185 65 35 1,000 0,01641129 0,08314088 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01731392 0,08752094 ! negative regulation of binding GO:0051100 58 36 1,000 0,01731392 0,087329 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01731392 0,08713791 GO:0046660|female sex differentiation, ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,01818332 0,09131361 ! protein amino acid N-linked glycosylation GO:0006487 49 37 1,000 0,01823724 0,09138487 ! regulation of protein secretion GO:0050708 51 37 1,000 0,01823724 0,09118621 ! maintenance of location in cell GO:0051651 69 38 1,000 0,01918099 0,09569689 ! synapse organization GO:0050808 55 39 1,000 0,0201449 0,10028847 ! response to calcium ion GO:0051592 58 40 1,000 0,02112874 0,10495917 ! regulation of tube size GO:0035150 60 40 1,000 0,02112874 0,10473297 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,02112874 0,10450774 ! peptide metabolic process GO:0006518 56 40 1,000 0,02112874 0,10428347 ! inner ear development GO:0048839 57 40 1,000 0,02112874 0,10406017 ! ATP synthesis coupled electron transport GO:0042773 48 40 1,000 0,02112874 0,10383782 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 1,000 0,02112874 0,10361641 ! double-strand break repair GO:0006302 67 40 1,000 0,02112874 0,10339595 ! B cell differentiation GO:0030183 62 40 1,000 0,02112874 0,10317643 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,02112874 0,10295783 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,02112874 0,10274016 ! glucose transport GO:0015758 52 41 1,000 0,02213225 0,10739277 ! cellular component disassembly GO:0022411 64 42 1,000 0,02315518 0,11211984 ! hexose transport GO:0008645 54 42 1,000 0,02315518 0,11188429 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02315518 0,11164974 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,02525836 0,12153603 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,02525836 0,12128231 ! positive regulation of defense response GO:0031349 59 45 1,000 0,02633811 0,12620346 ! regulation of translational initiation GO:0006446 64 45 1,000 0,02633811 0,12594108 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,02633811 0,12567979 ! regulation of ossification GO:0030278 71 46 1,000 0,02743633 0,13064918 ! histone modification GO:0016570 68 46 1,000 0,02743633 0,13037925 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02771948 0,13145319 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02771948 0,13118271 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02771948 0,13091334 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02771948 0,13064507 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02771948 0,1303779 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02771948 0,13011183 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02771948 0,12984683 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02771948 0,12958292 ! sleep GO:0030431 11 5 0,000 0,02771948 0,12932007 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02771948 0,12905829 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02771948 0,12879757 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02771948 0,12853789 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02771948 0,12827927 ! forebrain regionalization GO:0021871 6 5 0,000 0,02771948 0,12802168 ! tongue development GO:0043586 6 5 0,000 0,02771948 0,12776512 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02771948 0,12750959 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02771948 0,12725508 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02771948 0,12700158 ! cobalt ion transport GO:0006824 9 5 0,000 0,02771948 0,1267491 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02771948 0,12649761 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02771948 0,12624712 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02771948 0,12599762 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02771948 0,1257491 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02771948 0,12550156 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02771948 0,125255 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02771948 0,1250094 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02771948 0,12476476 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02771948 0,12452108 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02771948 0,12427835 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02771948 0,12403657 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02771948 0,12379572 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02771948 0,1235558 ! malate metabolic process GO:0006108 7 5 0,000 0,02771948 0,12331682 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02771948 0,12307875 ! behavioral response to pain GO:0048266 7 5 0,000 0,02771948 0,12284161 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02771948 0,12260537 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02771948 0,12237005 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02771948 0,12213562 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,02771948 0,12190209 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02771948 0,12166946 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02771948 0,1214377 ! rhythmic behavior GO:0007622 12 5 0,000 0,02771948 0,12120683 ! copulation GO:0007620 7 5 0,000 0,02771948 0,12097684 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02771948 0,12074772 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02771948 0,12051946 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02771948 0,12029207 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02771948 0,12006553 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02771948 0,11983984 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02771948 0,119615 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02771948 0,119391 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02771948 0,11916784 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02771948 0,11894551 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,02771948 0,11872401 ! lymph vessel development GO:0001945 7 5 0,000 0,02771948 0,11850334 ! endochondral ossification GO:0001958 12 5 0,000 0,02771948 0,11828348 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02771948 0,11806443 ! parathyroid gland development GO:0060017 8 5 0,000 0,02771948 0,1178462 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02771948 0,11762877 ! anagen GO:0042640 6 5 0,000 0,02771948 0,11741215 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02771948 0,11719631 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02771948 0,11698127 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02771948 0,11676702 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02771948 0,11655356 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02771948 0,11634087 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02771948 0,11612895 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02771948 0,11591781 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02771948 0,11570743 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02771948 0,11549782 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02771948 0,11528896 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02771948 0,11508086 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02771948 0,1148735 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02771948 0,1146669 ! ovulation GO:0030728 6 5 0,000 0,02771948 0,11446103 ! valine metabolic process GO:0006573 8 5 0,000 0,02771948 0,1142559 ! response to pH GO:0009268 9 5 0,000 0,02771948 0,11405151 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02771948 0,11384785 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02771948 0,11364491 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02771948 0,1134427 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02771948 0,1132412 ! polyol catabolic process GO:0046174 7 5 0,000 0,02771948 0,11304042 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02771948 0,11284034 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02771948 0,11264098 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02771948 0,11244232 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02771948 0,11224436 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02771948 0,11204709 ! urea metabolic process GO:0019627 6 5 0,000 0,02771948 0,11185052 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02771948 0,11165463 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02771948 0,11145943 ! neutrophil activation GO:0042119 5 5 0,000 0,02771948 0,11126491 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02771948 0,11107107 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02771948 0,1108779 ! response to food GO:0032094 5 5 0,000 0,02771948 0,11068541 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02771948 0,11049358 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02771948 0,11030241 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02771948 0,11011191 ! forebrain neuron development GO:0021884 7 5 0,000 0,02771948 0,10992206 ! melanosome organization GO:0032438 7 5 0,000 0,02771948 0,10973287 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02771948 0,10954432 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02771948 0,10935642 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02771948 0,10916917 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02771948 0,10898256 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02771948 0,10879658 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02771948 0,10861123 ! nucleoside transport GO:0015858 6 5 0,000 0,02771948 0,10842652 ! nucleoside salvage GO:0043174 7 5 0,000 0,02771948 0,10824244 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02771948 0,10805897 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02771948 0,10787613 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02771948 0,10769391 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02771948 0,1075123 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02771948 0,1073313 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02771948 0,10715092 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02771948 0,10697113 ! depyrimidination GO:0045008 8 5 0,000 0,02771948 0,10679195 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02771948 0,10661337 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02771948 0,10643538 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02771948 0,10625799 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02771948 0,10608119 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02771948 0,10590497 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02771948 0,10572934 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02771948 0,1055543 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02771948 0,10537983 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02771948 0,10520593 ! monocyte differentiation GO:0030224 8 5 0,000 0,02771948 0,10503261 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02771948 0,10485986 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02771948 0,10468768 ! centrosome duplication GO:0051298 5 5 0,000 0,02771948 0,10451606 ! response to UV-C GO:0010225 6 5 0,000 0,02771948 0,104345 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02771948 0,1041745 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02771948 0,10400456 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02771948 0,10383517 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02771948 0,10366633 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02771948 0,10349804 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02771948 0,1033303 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02771948 0,1031631 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02771948 0,10299644 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02771948 0,10283031 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02771948 0,10266473 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02771948 0,10249967 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02771948 0,10233514 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02771948 0,10217115 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02771948 0,10200767 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02771948 0,10184472 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02771948 0,10168229 ! neural tube patterning GO:0021532 6 5 0,000 0,02771948 0,10152037 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02771948 0,10135897 ! histone demethylation GO:0016577 9 5 0,000 0,02771948 0,10119809 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02771948 0,10103771 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02771948 0,10087784 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02771948 0,10071848 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02771948 0,10055961 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02771948 0,10040125 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02771948 0,10024339 ! transcription termination GO:0006353 8 5 0,000 0,02771948 0,10008602 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02771948 0,09992915 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02771948 0,09977276 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,02771948 0,09961687 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02771948 0,09946146 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02771948 0,09930653 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02771948 0,09915209 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02771948 0,09899813 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02771948 0,09884464 ! apical protein localization GO:0045176 6 5 0,000 0,02771948 0,09869163 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02771948 0,0985391 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02771948 0,09838703 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02771948 0,09823543 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02771948 0,0980843 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02771948 0,09793363 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02771948 0,09778343 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02771948 0,09763368 ! glial cell migration GO:0008347 10 5 0,000 0,02771948 0,0974844 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02771948 0,09733556 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02771948 0,09718719 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02771948 0,09703926 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02771948 0,09689179 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02771948 0,09674476 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02771948 0,09659817 ! neural plate development GO:0001840 6 5 0,000 0,02771948 0,09645203 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02771948 0,09630634 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02771948 0,09616108 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02771948 0,09601626 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02771948 0,09587187 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02771948 0,09572792 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02771948 0,0955844 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02771948 0,09544131 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02771948 0,09529865 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02771948 0,09515641 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! spindle assembly GO:0051225 5 5 0,000 0,02771948 0,0950146 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02771948 0,09487321 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02771948 0,09473224 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02771948 0,09459168 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02771948 0,09445155 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02771948 0,09431183 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02771948 0,09417252 GO:0055081|anion homeostasis, ! respiratory electron transport chain GO:0022904 59 47 1,000 0,02855277 0,09686042 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02855277 0,09671777 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,02855277 0,09657554 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,02855277 0,09643372 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02855277 0,09629233 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,0296872 0,09997152 ! response to temperature stimulus GO:0009266 62 48 1,000 0,0296872 0,09982537 ! RNA elongation GO:0006354 62 49 1,000 0,03083938 0,10354829 ! maintenance of location GO:0051235 84 49 1,000 0,03083938 0,10339734 ! ear development GO:0043583 72 50 1,000 0,03200909 0,10716291 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,03200909 0,10700715 ! lipid modification GO:0030258 73 50 1,000 0,03200909 0,10685184 ! tRNA transcription GO:0009304 11 6 0,000 0,03317141 0,11057137 ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03317141 0,11041136 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03317141 0,1102518 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03317141 0,11009271 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03317141 0,10993408 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03317141 0,1097759 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03317141 0,10961817 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03317141 0,1094609 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03317141 0,10930408 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03317141 0,10914771 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03317141 0,10899178 ! prostate gland development GO:0030850 9 6 0,000 0,03317141 0,1088363 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03317141 0,10868127 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03317141 0,10852667 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03317141 0,10837251 GO:0021872|generation of neurons in the forebrain, ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03317141 0,10821879 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03317141 0,10806551 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03317141 0,10791266 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03317141 0,10776024 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,03317141 0,10760825 ! neuron adhesion GO:0007158 9 6 0,000 0,03317141 0,10745669 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03317141 0,10730555 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03317141 0,10715484 ! signal peptide processing GO:0006465 8 6 0,000 0,03317141 0,10700456 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03317141 0,10685469 ! mRNA stabilization GO:0048255 15 6 0,000 0,03317141 0,10670524 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03317141 0,10655621 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03317141 0,1064076 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03317141 0,1062594 ! opsonization GO:0008228 8 6 0,000 0,03317141 0,10611161 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03317141 0,10596423 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03317141 0,10581727 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03317141 0,1056707 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03317141 0,10552455 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03317141 0,1053788 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03317141 0,10523345 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03317141 0,1050885 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03317141 0,10494395 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03317141 0,10479979 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03317141 0,10465603 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03317141 0,10451267 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03317141 0,1043697 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03317141 0,10422712 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03317141 0,10408492 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03317141 0,10394312 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03317141 0,1038017 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03317141 0,10366066 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03317141 0,10352001 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03317141 0,10337974 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03317141 0,10323985 ! thymic T cell selection GO:0045061 12 6 0,000 0,03317141 0,10310034 ! protein lipoylation GO:0009249 10 6 0,000 0,03317141 0,1029612 ! pigment granule organization GO:0048753 11 6 0,000 0,03317141 0,10282244 ! drug transport GO:0015893 6 6 0,000 0,03317141 0,10268405 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03317141 0,10254603 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03317141 0,10240839 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03317141 0,10227111 ! histidine metabolic process GO:0006547 6 6 0,000 0,03317141 0,1021342 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03317141 0,10199766 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03317141 0,10186148 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03317141 0,10172566 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03317141 0,10159021 ! adenohypophysis development GO:0021984 10 6 0,000 0,03317141 0,10145512 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03317141 0,10132038 ! hyperosmotic response GO:0006972 8 6 0,000 0,03317141 0,10118601 ! microtubule nucleation GO:0007020 10 6 0,000 0,03317141 0,10105198 ! ER overload response GO:0006983 7 6 0,000 0,03317141 0,10091832 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03317141 0,100785 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03317141 0,10065204 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03317141 0,10051943 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03317141 0,10038717 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03317141 0,10025525 ! response to dietary excess GO:0002021 7 6 0,000 0,03317141 0,10012369 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03317141 0,09999246 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03317141 0,09986158 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03317141 0,09973104 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03317141 0,09960085 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03317141 0,09947099 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03317141 0,09934147 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03317141 0,09921229 ! neuron apoptosis GO:0051402 8 6 0,000 0,03317141 0,09908344 ! organic alcohol transport GO:0015850 9 6 0,000 0,03317141 0,09895493 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03317141 0,09882675 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03317141 0,0986989 ! male sex determination GO:0030238 9 6 0,000 0,03317141 0,09857138 ! carnitine transport GO:0015879 8 6 0,000 0,03317141 0,09844419 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03317141 0,09831733 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03317141 0,0981908 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03317141 0,09806459 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03317141 0,0979387 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03317141 0,09781314 ! parturition GO:0007567 12 6 0,000 0,03317141 0,0976879 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03317141 0,09756298 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03317141 0,09743838 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03317141 0,09731409 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03317141 0,09719013 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03317141 0,09706647 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03317141 0,09694314 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03317141 0,09682011 ! macrophage differentiation GO:0030225 10 6 0,000 0,03317141 0,0966974 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03317141 0,096575 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03317141 0,09645291 ! interaction with symbiont GO:0051702 8 6 0,000 0,03317141 0,09633112 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03317141 0,09620964 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03317141 0,09608847 ! eating behavior GO:0042755 6 6 0,000 0,03317141 0,09596761 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03317141 0,09584705 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03317141 0,09572679 ! DNA topological change GO:0006265 8 6 0,000 0,03317141 0,09560683 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03317141 0,09548717 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03317141 0,09536781 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03317141 0,09524875 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03317141 0,09512999 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03317141 0,09501152 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03317141 0,09489334 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03317141 0,09477546 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03317141 0,09465788 ! gas homeostasis GO:0033483 11 6 0,000 0,03317141 0,09454058 ! hair follicle maturation GO:0048820 7 6 0,000 0,03317141 0,09442357 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03317141 0,09430686 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03317141 0,09419043 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03317141 0,09407429 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03317141 0,09395843 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03317141 0,09384286 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03317141 0,09372758 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,03317141 0,09361257 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03317141 0,09349785 ! histone ubiquitination GO:0016574 7 6 0,000 0,03317141 0,09338341 ! regulation of meiosis GO:0040020 10 6 0,000 0,03317141 0,09326925 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03317141 0,09315537 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03317141 0,09304177 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03317141 0,09292844 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03317141 0,09281539 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03317141 0,09270261 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03317141 0,09259011 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03317141 0,09247788 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03317141 0,09236592 ! receptor internalization GO:0031623 9 6 0,000 0,03317141 0,09225423 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03317141 0,09214281 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03317141 0,09203166 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,03317141 0,09192078 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03317141 0,09181017 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03317141 0,09169982 ! axonal fasciculation GO:0007413 9 6 0,000 0,03317141 0,09158973 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03317141 0,09147991 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03317141 0,09137036 ! midbrain development GO:0030901 6 6 0,000 0,03317141 0,09126106 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03317141 0,09115203 ! regulation of viral transcription GO:0046782 8 6 0,000 0,03317141 0,09104326 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03317141 0,09093474 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03317141 0,09082649 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03317141 0,09071849 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03317141 0,09061075 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03317141 0,09050326 GO:0010828|positive regulation of glucose transport, ! adult feeding behavior GO:0008343 6 6 0,000 0,03317141 0,09039603 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03317141 0,09028905 ! blastocyst growth GO:0001832 15 6 0,000 0,03317141 0,09018233 ! pigment granule transport GO:0051904 12 6 0,000 0,03317141 0,09007585 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03317141 0,08996963 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03317141 0,08986366 ! catecholamine transport GO:0051937 7 6 0,000 0,03317141 0,08975794 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03317141 0,08965247 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03317141 0,08954724 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03317141 0,08944226 ! protein prenylation GO:0018342 10 6 0,000 0,03317141 0,08933753 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03317141 0,08923304 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,03317141 0,08912879 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03317141 0,08902479 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03317141 0,08892104 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03317141 0,08881752 ! positive regulation of secretion GO:0051047 71 51 1,000 0,03319611 0,08878028 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03319611 0,08867717 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,03319611 0,0885743 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,03319611 0,08847166 ! transition metal ion transport GO:0000041 74 52 1,000 0,03440019 0,09157458 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03440019 0,09146871 ! aging GO:0007568 79 52 1,000 0,03440019 0,09136309 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,03562112 0,09449663 ! regulation of neurotransmitter levels GO:0001505 73 53 1,000 0,03562112 0,09438776 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,03562112 0,09427914 ! cell projection assembly GO:0030031 76 53 1,000 0,03562112 0,09417077 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,03685868 0,0973306 ! DNA catabolic process GO:0006308 67 54 1,000 0,03685868 0,09721898 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,03685868 0,09710762 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,03685868 0,09699651 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03859309 0,10144469 GO:0016446|somatic hypermutation of immunoglobulin genes, ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03859309 0,10132888 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03859309 0,10121334 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03859309 0,10109807 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03859309 0,10098305 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03859309 0,1008683 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03859309 0,1007538 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03859309 0,10063957 ! reproductive behavior GO:0019098 12 7 0,000 0,03859309 0,1005256 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03859309 0,10041188 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,03859309 0,10029842 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03859309 0,10018522 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03859309 0,10007227 ! oligopeptide transport GO:0006857 11 7 0,000 0,03859309 0,09995957 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03859309 0,09984713 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03859309 0,09973495 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,03859309 0,09962301 ! pericardium development GO:0060039 8 7 0,000 0,03859309 0,09951133 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03859309 0,09939989 ! fibril organization GO:0043206 13 7 0,000 0,03859309 0,0992887 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03859309 0,09917777 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03859309 0,09906708 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,03859309 0,09895664 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03859309 0,09884644 ! lipoprotein transport GO:0042953 9 7 0,000 0,03859309 0,09873649 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03859309 0,09862678 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03859309 0,09851732 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03859309 0,0984081 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03859309 0,09829912 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03859309 0,09819038 ! chemosensory behavior GO:0007635 9 7 0,000 0,03859309 0,09808188 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03859309 0,09797362 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,03859309 0,0978656 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03859309 0,09775782 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03859309 0,09765028 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03859309 0,09754297 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03859309 0,0974359 ! reflex GO:0060004 12 7 0,000 0,03859309 0,09732906 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03859309 0,09722246 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03859309 0,09711609 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03859309 0,09700995 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03859309 0,09690404 ! spinal cord patterning GO:0021511 7 7 0,000 0,03859309 0,09679837 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03859309 0,09669292 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03859309 0,09658771 ! adrenal gland development GO:0030325 17 7 0,000 0,03859309 0,09648272 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03859309 0,09637796 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03859309 0,09627343 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03859309 0,09616912 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03859309 0,09606505 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03859309 0,09596119 ! endosome organization GO:0007032 10 7 0,000 0,03859309 0,09585756 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03859309 0,09575416 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03859309 0,09565097 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03859309 0,09554801 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03859309 0,09544527 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03859309 0,09534275 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03859309 0,09524045 GO:0021952|central nervous system projection neuron axonogenesis, ! galactose metabolic process GO:0006012 10 7 0,000 0,03859309 0,09513837 ! vesicle fusion GO:0006906 15 7 0,000 0,03859309 0,09503651 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03859309 0,09493487 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03859309 0,09483344 ! organ growth GO:0035265 11 7 0,000 0,03859309 0,09473223 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03859309 0,09463124 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03859309 0,09453046 ! retinol metabolic process GO:0042572 9 7 0,000 0,03859309 0,0944299 ! behavioral fear response GO:0001662 13 7 0,000 0,03859309 0,09432955 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03859309 0,09422941 ! rRNA modification GO:0000154 12 7 0,000 0,03859309 0,09412948 ! protein heterooligomerization GO:0051291 10 7 0,000 0,03859309 0,09402977 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03859309 0,09393027 ! response to UV-B GO:0010224 11 7 0,000 0,03859309 0,09383097 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03859309 0,09373189 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03859309 0,09363302 ! intermediate filament organization GO:0045109 11 7 0,000 0,03859309 0,09353435 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03859309 0,0934359 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03859309 0,09333765 ! fibrinolysis GO:0042730 9 7 0,000 0,03859309 0,0932396 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03859309 0,09314177 ! B cell lineage commitment GO:0002326 17 7 0,000 0,03859309 0,09304413 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03859309 0,0929467 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03859309 0,09284948 ! response to tropane GO:0014073 13 7 0,000 0,03859309 0,09275246 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03859309 0,09265564 ! melanosome localization GO:0032400 10 7 0,000 0,03859309 0,09255902 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03859309 0,09246261 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03859309 0,09236639 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03859309 0,09227038 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03859309 0,09217456 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03859309 0,09207894 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03859309 0,09198353 ! mast cell activation GO:0045576 9 7 0,000 0,03859309 0,0918883 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03859309 0,09179328 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03859309 0,09169845 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03859309 0,09160382 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03859309 0,09150938 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,03859309 0,09141514 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03859309 0,09132109 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03859309 0,09122724 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03859309 0,09113358 ! T cell lineage commitment GO:0002360 12 7 0,000 0,03859309 0,0910401 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03859309 0,09094683 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03859309 0,09085374 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03859309 0,09076084 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03859309 0,09066813 ! response to tumor cell GO:0002347 12 7 0,000 0,03859309 0,09057561 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03859309 0,09048328 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03859309 0,09039114 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03859309 0,09029919 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03859309 0,09020742 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03859309 0,09011584 ! diuresis GO:0030146 12 7 0,000 0,03859309 0,09002444 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03859309 0,08993323 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03859309 0,08984221 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03859309 0,08975137 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03859309 0,08966071 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03859309 0,08957023 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03859309 0,08947994 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03859309 0,08938983 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03859309 0,0892999 ! lymph node development GO:0048535 9 7 0,000 0,03859309 0,08921015 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03859309 0,08912058 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03859309 0,0890312 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03859309 0,08894199 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03859309 0,08885296 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03859309 0,0887641 ! ATP catabolic process GO:0006200 10 7 0,000 0,03859309 0,08867543 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03859309 0,08858693 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03859309 0,08849861 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03859309 0,08841046 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03859309 0,08832249 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03859309 0,08823469 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03859309 0,08814707 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03859309 0,08805963 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03859309 0,08797235 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03859309 0,08788525 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03859309 0,08779832 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03859309 0,08771156 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03859309 0,08762498 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03859309 0,08753856 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03859309 0,08745232 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,03938278 0,08915394 ! carbohydrate transport GO:0008643 74 57 1,000 0,0406689 0,09197489 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,0406689 0,09188454 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,0406689 0,09179437 ! gonad development GO:0008406 79 57 1,000 0,0406689 0,09170438 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,04197077 0,09454727 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,04328818 0,09741958 ! lung development GO:0030324 94 59 1,000 0,04328818 0,09732435 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04398467 0,09879369 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04398467 0,09869731 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04398467 0,09860111 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04398467 0,0985051 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04398467 0,09840928 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04398467 0,09831364 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04398467 0,09821819 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04398467 0,09812293 ! phosphate transport GO:0006817 10 8 0,000 0,04398467 0,09802785 ! N-glycan processing GO:0006491 12 8 0,000 0,04398467 0,09793295 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04398467 0,09783824 ! UTP metabolic process GO:0046051 8 8 0,000 0,04398467 0,09774371 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04398467 0,09764936 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04398467 0,0975552 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,04398467 0,09746121 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04398467 0,09736741 ! succinate metabolic process GO:0006105 14 8 0,000 0,04398467 0,09727379 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,04398467 0,09718034 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04398467 0,09708708 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04398467 0,096994 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,04398467 0,09690109 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,04398467 0,09680836 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04398467 0,09671581 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04398467 0,09662344 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04398467 0,09653124 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04398467 0,09643922 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04398467 0,09634737 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04398467 0,0962557 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04398467 0,0961642 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04398467 0,09607288 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04398467 0,09598173 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04398467 0,09589075 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04398467 0,09579994 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04398467 0,09570931 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04398467 0,09561885 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04398467 0,09552855 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04398467 0,09543843 ! melanin metabolic process GO:0006582 12 8 0,000 0,04398467 0,09534848 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04398467 0,0952587 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04398467 0,09516909 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,04398467 0,09507964 ! macrophage activation GO:0042116 12 8 0,000 0,04398467 0,09499036 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04398467 0,09490126 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04398467 0,09481231 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04398467 0,09472354 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04398467 0,09463493 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04398467 0,09454648 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04398467 0,09445821 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04398467 0,09437009 ! ruffle organization GO:0031529 11 8 0,000 0,04398467 0,09428214 ! osteoblast development GO:0002076 13 8 0,000 0,04398467 0,09419436 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04398467 0,09410673 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04398467 0,09401927 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04398467 0,09393198 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04398467 0,09384484 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04398467 0,09375787 GO:0030204|chondroitin sulfate metabolic process, ! regulation of gliogenesis GO:0014013 20 8 0,000 0,04398467 0,09367105 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,04398467 0,0935844 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04398467 0,09349791 ! segment specification GO:0007379 10 8 0,000 0,04398467 0,09341158 ! cellular extravasation GO:0045123 11 8 0,000 0,04398467 0,0933254 ! pigment granule localization GO:0051875 14 8 0,000 0,04398467 0,09323939 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04398467 0,09315353 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04398467 0,09306784 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04398467 0,0929823 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04398467 0,09289691 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04398467 0,09281169 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04398467 0,09272662 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04398467 0,0926417 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04398467 0,09255694 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04398467 0,09247234 ! icosanoid secretion GO:0032309 12 8 0,000 0,04398467 0,09238789 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04398467 0,09230359 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04398467 0,09221945 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04398467 0,09213546 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04398467 0,09205163 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04398467 0,09196794 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04398467 0,09188441 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04398467 0,09180103 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04398467 0,0917178 ! sterol catabolic process GO:0016127 9 8 0,000 0,04398467 0,09163473 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04398467 0,0915518 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04398467 0,09146902 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04398467 0,09138639 ! prophase GO:0051324 11 8 0,000 0,04398467 0,09130392 ! S phase GO:0051320 8 8 0,000 0,04398467 0,09122159 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04398467 0,0911394 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04398467 0,09105737 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04398467 0,09097548 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04398467 0,09089375 ! hormone catabolic process GO:0042447 13 8 0,000 0,04398467 0,09081215 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04398467 0,09073071 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04398467 0,09064941 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04398467 0,09056825 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04398467 0,09048724 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,04398467 0,09040638 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04398467 0,09032566 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04398467 0,09024508 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04398467 0,09016465 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04398467 0,09008436 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04398467 0,09000422 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04398467 0,08992421 ! regulation of embryonic development GO:0045995 16 8 0,000 0,04398467 0,08984435 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04398467 0,08976463 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04398467 0,08968505 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,04398467 0,08960561 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,04462092 0,09082134 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,04462092 0,09074104 ! neurotransmitter transport GO:0006836 81 62 1,000 0,04733155 0,09616835 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,04733155 0,09608347 ! respiratory tube development GO:0030323 99 62 1,000 0,04733155 0,09599874 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,04870904 0,09870554 ! regulation of lipase activity GO:0060191 109 63 1,000 0,04870904 0,09861865 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04934632 0,09982105 ! regulation of developmental growth GO:0048638 13 9 0,000 0,04934632 0,09973334 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,04934632 0,09964577 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04934632 0,09955837 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04934632 0,09947111 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04934632 0,09938401 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04934632 0,09929706 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04934632 0,09921026 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04934632 0,09912361 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04934632 0,09903712 ! GTP metabolic process GO:0046039 9 9 0,000 0,04934632 0,09895077 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04934632 0,09886458 ! social behavior GO:0035176 14 9 0,000 0,04934632 0,09877854 ! artery development GO:0060840 19 9 0,000 0,04934632 0,09869264 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04934632 0,0986069 ! regulation of glycolysis GO:0006110 15 9 0,000 0,04934632 0,0985213 ! response to pain GO:0048265 16 9 0,000 0,04934632 0,09843585 ! protein complex disassembly GO:0043241 17 9 0,000 0,04934632 0,09835055 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04934632 0,0982654 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04934632 0,0981804 ! lung alveolus development GO:0048286 17 9 0,000 0,04934632 0,09809554 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04934632 0,09801083 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04934632 0,09792626 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04934632 0,09784184 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04934632 0,09775757 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04934632 0,09767344 ! protein targeting to ER GO:0045047 19 9 0,000 0,04934632 0,09758946 ! T cell selection GO:0045058 18 9 0,000 0,04934632 0,09750562 ! endoderm development GO:0007492 12 9 0,000 0,04934632 0,09742192 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04934632 0,09733837 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04934632 0,09725496 ! arginine catabolic process GO:0006527 10 9 0,000 0,04934632 0,09717169 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04934632 0,09708857 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04934632 0,09700559 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04934632 0,09692275 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04934632 0,09684005 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04934632 0,09675749 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04934632 0,09667507 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04934632 0,0965928 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04934632 0,09651066 ! mannose metabolic process GO:0006013 9 9 0,000 0,04934632 0,09642866 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04934632 0,09634681 ! receptor clustering GO:0043113 15 9 0,000 0,04934632 0,09626509 ! epithelial cell development GO:0002064 10 9 0,000 0,04934632 0,09618351 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04934632 0,09610206 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04934632 0,09602076 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04934632 0,09593959 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04934632 0,09585856 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04934632 0,09577767 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04934632 0,09569691 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04934632 0,09561629 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04934632 0,09553581 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04934632 0,09545546 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04934632 0,09537524 ! DNA ligation GO:0006266 14 9 0,000 0,04934632 0,09529516 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04934632 0,09521522 ! response to amine stimulus GO:0014075 13 9 0,000 0,04934632 0,0951354 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04934632 0,09505573 ! erythrocyte development GO:0048821 11 9 0,000 0,04934632 0,09497618 ! renal water homeostasis GO:0003091 14 9 0,000 0,04934632 0,09489677 ! postreplication repair GO:0006301 11 9 0,000 0,04934632 0,09481749 ! mRNA cleavage GO:0006379 13 9 0,000 0,04934632 0,09473835 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04934632 0,09465933 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04934632 0,09458045 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04934632 0,0945017 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04934632 0,09442308 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04934632 0,09434459 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04934632 0,09426623 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04934632 0,094188 ! acid secretion GO:0046717 14 9 0,000 0,04934632 0,0941099 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04934632 0,09403193 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04934632 0,09395409 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04934632 0,09387637 ! purine base metabolic process GO:0006144 18 9 0,000 0,04934632 0,09379879 ! oocyte differentiation GO:0009994 12 9 0,000 0,04934632 0,09372134 GO:0048599|oocyte development, ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04934632 0,09364401 ! spleen development GO:0048536 15 9 0,000 0,04934632 0,09356681 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04934632 0,09348973 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04934632 0,09341279 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04934632 0,09333597 ! blastocyst formation GO:0001825 12 9 0,000 0,04934632 0,09325927 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04934632 0,09318271 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04934632 0,09310627 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04934632 0,09302995 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04934632 0,09295376 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04934632 0,09287769 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04934632 0,09280175 ! prepulse inhibition GO:0060134 14 9 0,000 0,04934632 0,09272593 ! embryonic placenta development GO:0001892 12 9 0,000 0,04934632 0,09265023 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04934632 0,09257466 ! insulin secretion GO:0030073 17 9 0,000 0,04934632 0,09249922 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04934632 0,09242389 ! response to nicotine GO:0035094 16 9 0,000 0,04934632 0,09234869 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04934632 0,09227361 ! nucleus localization GO:0051647 15 9 0,000 0,04934632 0,09219865 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04934632 0,09212381 ! negative regulation of cell size GO:0045792 108 64 1,000 0,05010102 0,09345689 ! respiratory system development GO:0060541 100 64 1,000 0,05010102 0,09338116 ! adaptive immune response GO:0002250 94 64 1,000 0,05010102 0,09330554 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,05150731 0,09584693 ! B cell activation GO:0042113 104 65 1,000 0,05150731 0,09576945 ! defense response to bacterium GO:0042742 73 65 1,000 0,05150731 0,09569209 ! axon guidance GO:0007411 99 66 1,000 0,05292769 0,09825157 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,05292769 0,09817234 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,05436198 0,10075146 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,05436198 0,10067034 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05467821 0,10117448 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05467821 0,10109315 ! neuron fate specification GO:0048665 11 10 0,000 0,05467821 0,10101195 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05467821 0,10093088 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05467821 0,10084994 ! thyroid gland development GO:0030878 19 10 0,000 0,05467821 0,10076913 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05467821 0,10068845 ! synapsis GO:0007129 13 10 0,000 0,05467821 0,1006079 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05467821 0,10052748 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05467821 0,10044719 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05467821 0,10036702 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,05467821 0,10028698 ! sulfate transport GO:0008272 12 10 0,000 0,05467821 0,10020707 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05467821 0,10012729 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05467821 0,10004764 ! androgen metabolic process GO:0008209 13 10 0,000 0,05467821 0,09996811 ! phospholipid efflux GO:0033700 16 10 0,000 0,05467821 0,0998887 ! hippocampus development GO:0021766 19 10 0,000 0,05467821 0,09980943 ! blood vessel remodeling GO:0001974 21 10 0,000 0,05467821 0,09973028 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05467821 0,09965125 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05467821 0,09957235 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 0,000 0,05467821 0,09949357 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05467821 0,09941492 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05467821 0,0993364 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05467821 0,09925799 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,05467821 0,09917971 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05467821 0,09910156 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05467821 0,09902353 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05467821 0,09894562 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05467821 0,09886783 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05467821 0,09879016 ! response to X-ray GO:0010165 16 10 0,000 0,05467821 0,09871262 ! B cell proliferation GO:0042100 14 10 0,000 0,05467821 0,0986352 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05467821 0,0985579 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05467821 0,09848072 ! lipid digestion GO:0044241 15 10 0,000 0,05467821 0,09840366 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05467821 0,09832672 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05467821 0,0982499 ! UV protection GO:0009650 14 10 0,000 0,05467821 0,09817321 ! entry into host cell GO:0030260 20 10 0,000 0,05467821 0,09809663 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,05467821 0,09802017 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05467821 0,09794383 ! negative regulation of ossification GO:0030279 19 10 0,000 0,05467821 0,09786761 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,05467821 0,09779151 ! regulation of bone resorption GO:0045124 24 10 0,000 0,05467821 0,09771552 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,05467821 0,09763966 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05467821 0,09756391 ! response to dsRNA GO:0043331 18 10 0,000 0,05467821 0,09748828 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05467821 0,09741276 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05467821 0,09733737 ! embryonic axis specification GO:0000578 12 10 0,000 0,05467821 0,09726209 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05467821 0,09718692 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05467821 0,09711187 ! fucose catabolic process GO:0019317 16 10 0,000 0,05467821 0,09703694 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,05467821 0,09696213 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05467821 0,09688742 ! protein sumoylation GO:0016925 12 10 0,000 0,05467821 0,09681284 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05467821 0,09673837 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05467821 0,09666401 ! zymogen activation GO:0031638 14 10 0,000 0,05467821 0,09658977 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05467821 0,09651564 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05467821 0,09644162 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05467821 0,09636772 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05467821 0,09629393 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05467821 0,09622026 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05467821 0,0961467 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05467821 0,09607324 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,05467821 0,09599991 GO:0043470|regulation of carbohydrate catabolic process, ! detection of bacterium GO:0016045 10 10 0,000 0,05467821 0,09592668 ! embryonic gut development GO:0048566 11 10 0,000 0,05467821 0,09585357 ! activation of innate immune response GO:0002218 10 10 0,000 0,05467821 0,09578056 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05467821 0,09570767 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05467821 0,09563489 ! developmental induction GO:0031128 13 10 0,000 0,05467821 0,09556222 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05467821 0,09548966 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05467821 0,09541721 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05467821 0,09534487 ! learning or memory GO:0007611 123 68 1,000 0,05580998 0,09724466 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,05580998 0,09717105 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,05580998 0,09709754 ! rhythmic process GO:0048511 105 68 1,000 0,05580998 0,09702415 ! response to drug GO:0042493 108 69 1,000 0,05727148 0,09948974 ! humoral immune response GO:0006959 86 70 1,000 0,05874631 0,10197472 ! eye development GO:0001654 111 70 1,000 0,05874631 0,10189781 ! rRNA transcription GO:0009303 17 11 0,000 0,05998049 0,10396016 ! respiratory burst GO:0045730 14 11 0,000 0,05998049 0,10388188 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05998049 0,10380371 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,05998049 0,10372566 ! virus-host interaction GO:0019048 17 11 0,000 0,05998049 0,10364773 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,05998049 0,10356992 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,05998049 0,10349222 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,05998049 0,10341464 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05998049 0,10333718 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,05998049 0,10325983 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,05998049 0,1031826 ! mating GO:0007618 14 11 0,000 0,05998049 0,10310548 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,05998049 0,10302848 ! T cell proliferation GO:0042098 20 11 0,000 0,05998049 0,10295159 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,05998049 0,10287482 ! bone resorption GO:0045453 16 11 0,000 0,05998049 0,10279816 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05998049 0,10272162 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,05998049 0,10264519 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! regulation of mRNA processing GO:0050684 18 11 0,000 0,05998049 0,10256887 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05998049 0,10249267 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05998049 0,10241658 ! syncytium formation GO:0006949 15 11 0,000 0,05998049 0,1023406 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05998049 0,10226474 ! focal adhesion formation GO:0048041 24 11 0,000 0,05998049 0,10218899 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05998049 0,10211335 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05998049 0,10203782 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,05998049 0,10196241 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,05998049 0,1018871 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05998049 0,10181191 ! adult heart development GO:0007512 11 11 0,000 0,05998049 0,10173682 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,05998049 0,10166185 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,05998049 0,10158699 ! L-glutamate transport GO:0015813 16 11 0,000 0,05998049 0,10151224 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05998049 0,1014376 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05998049 0,10136307 ! stem cell development GO:0048864 29 11 0,000 0,05998049 0,10128864 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,05998049 0,10121433 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,05998049 0,10114013 ! vasoconstriction GO:0042310 15 11 0,000 0,05998049 0,10106603 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05998049 0,10099205 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05998049 0,10091817 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,05998049 0,1008444 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05998049 0,10077073 ! ribosome assembly GO:0042255 13 11 0,000 0,05998049 0,10069718 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05998049 0,10062373 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,05998049 0,10055039 ! chromatin silencing GO:0006342 19 11 0,000 0,05998049 0,10047716 ! nucleosome positioning GO:0016584 13 11 0,000 0,05998049 0,10040403 ! T cell homeostasis GO:0043029 20 11 0,000 0,05998049 0,10033101 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,05998049 0,10025809 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05998049 0,10018528 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05998049 0,10011258 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,05998049 0,10003998 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,05998049 0,09996749 ! male genitalia development GO:0030539 13 11 0,000 0,05998049 0,0998951 ! cholesterol efflux GO:0033344 19 11 0,000 0,05998049 0,09982282 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,05998049 0,09975064 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05998049 0,09967857 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05998049 0,0996066 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,05998049 0,09953473 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,05998049 0,09946297 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05998049 0,09939131 ! defense response to fungus GO:0050832 12 11 0,000 0,05998049 0,09931975 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05998049 0,0992483 ! lysogeny GO:0030069 18 11 0,000 0,05998049 0,09917695 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05998049 0,0991057 ! acrosome reaction GO:0007340 13 11 0,000 0,05998049 0,09903455 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,06023425 0,09938219 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,06023425 0,09931095 ! response to hypoxia GO:0001666 132 72 1,000 0,06173513 0,10171261 ! regulation of blood pressure GO:0008217 107 73 1,000 0,06324876 0,10413182 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,06324876 0,10405733 ! response to oxygen levels GO:0070482 137 74 1,000 0,06477495 0,10649206 ! lactation GO:0007595 20 12 0,000 0,06525334 0,10720192 ! reproductive cellular process GO:0048610 14 12 0,000 0,06525334 0,1071254 ! tRNA modification GO:0006400 14 12 0,000 0,06525334 0,10704899 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,06525334 0,10697269 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,06525334 0,1068965 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,06525334 0,10682041 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,06525334 0,10674444 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,06525334 0,10666857 ! non-recombinational repair GO:0000726 19 12 0,000 0,06525334 0,10659281 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,06525334 0,10651716 ! peroxisomal transport GO:0043574 21 12 0,000 0,06525334 0,10644162 ! cartilage condensation GO:0001502 18 12 0,000 0,06525334 0,10636618 ! heart looping GO:0001947 15 12 0,000 0,06525334 0,10629085 ! palate development GO:0060021 15 12 0,000 0,06525334 0,10621563 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,06525334 0,10614051 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,06525334 0,1060655 ! arginine metabolic process GO:0006525 13 12 0,000 0,06525334 0,1059906 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,06525334 0,1059158 ! methionine metabolic process GO:0006555 13 12 0,000 0,06525334 0,1058411 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,06525334 0,10576651 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,06525334 0,10569203 ! monoamine transport GO:0015844 13 12 0,000 0,06525334 0,10561765 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06525334 0,10554338 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,06525334 0,10546921 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,06525334 0,10539514 ! L-amino acid transport GO:0015807 20 12 0,000 0,06525334 0,10532118 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,06525334 0,10524732 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,06525334 0,10517357 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,06525334 0,10509992 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06525334 0,10502637 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,06525334 0,10495293 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,06525334 0,10487958 ! cerebellum development GO:0021549 13 12 0,000 0,06525334 0,10480634 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,06525334 0,1047332 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,06525334 0,10466017 ! histone methylation GO:0016571 15 12 0,000 0,06525334 0,10458724 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,06525334 0,1045144 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,06525334 0,10444167 ! response to gamma radiation GO:0010332 20 12 0,000 0,06525334 0,10436904 ! regulation of epidermis development GO:0045682 17 12 0,000 0,06525334 0,10429651 ! intestinal absorption GO:0050892 19 12 0,000 0,06525334 0,10422409 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,06525334 0,10415176 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,06525334 0,10407953 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,06525334 0,1040074 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,06525334 0,10393538 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,06525334 0,10386345 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,06525334 0,10379162 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,06525334 0,10371989 ! microspike assembly GO:0030035 23 12 0,000 0,06525334 0,10364826 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,06525334 0,10357673 ! response to cold GO:0009409 14 12 0,000 0,06525334 0,1035053 ! blood coagulation GO:0007596 116 75 1,000 0,06631351 0,10511446 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 1,000 0,06631351 0,10504207 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,06786427 0,10742451 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,06942703 0,10982268 ! sex differentiation GO:0007548 105 77 1,000 0,06942703 0,1097472 ! protein ubiquitination GO:0016567 125 77 1,000 0,06942703 0,10967182 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07049691 0,11128545 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07049691 0,11120912 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07049691 0,1111329 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,07049691 0,11105678 GO:0042044|fluid transport, ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07049691 0,11098076 ! lipid localization GO:0010876 24 13 0,000 0,07049691 0,11090485 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07049691 0,11082905 ! organelle fusion GO:0048284 28 13 0,000 0,07049691 0,11075334 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07049691 0,11067774 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07049691 0,11060225 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07049691 0,11052685 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07049691 0,11045156 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07049691 0,11037637 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07049691 0,11030129 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07049691 0,1102263 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07049691 0,11015142 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! NAD metabolic process GO:0019674 21 13 0,000 0,07049691 0,11007664 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,07049691 0,11000196 ! bone mineralization GO:0030282 15 13 0,000 0,07049691 0,10992739 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07049691 0,10985291 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07049691 0,10977853 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07049691 0,10970426 ! genitalia development GO:0048806 15 13 0,000 0,07049691 0,10963008 ! regulation of cellular pH GO:0030641 20 13 0,000 0,07049691 0,10955601 ! cellular pigmentation GO:0033059 24 13 0,000 0,07049691 0,10948204 ! tissue regeneration GO:0042246 21 13 0,000 0,07049691 0,10940816 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07049691 0,10933439 ! cofactor transport GO:0051181 19 13 0,000 0,07049691 0,10926071 ! NADP metabolic process GO:0006739 18 13 0,000 0,07049691 0,10918713 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07049691 0,10911366 ! gas transport GO:0015669 18 13 0,000 0,07049691 0,10904028 ! regulation of RNA stability GO:0043487 28 13 0,000 0,07049691 0,108967 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07049691 0,10889382 ! regulation of axon extension GO:0030516 23 13 0,000 0,07049691 0,10882073 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07049691 0,10874775 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,07049691 0,10867486 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07049691 0,10860207 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07049691 0,10852938 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07049691 0,10845679 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07049691 0,10838429 ! cellular respiration GO:0045333 107 79 1,000 0,07258787 0,11152445 ! oxidative phosphorylation GO:0006119 105 79 1,000 0,07258787 0,11145001 ! forebrain development GO:0030900 131 80 1,000 0,07418559 0,11382713 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,07571136 0,11609076 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,07571136 0,11601342 ! neuron maturation GO:0042551 21 14 0,000 0,07571136 0,11593618 ! regulation of S phase GO:0033261 18 14 0,000 0,07571136 0,11585904 ! myotube differentiation GO:0014902 21 14 0,000 0,07571136 0,11578201 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,07571136 0,11570508 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,07571136 0,11562825 ! inositol metabolic process GO:0006020 20 14 0,000 0,07571136 0,11555152 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,07571136 0,11547489 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,07571136 0,11539837 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,07571136 0,11532195 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,07571136 0,11524562 ! gene silencing by RNA GO:0031047 20 14 0,000 0,07571136 0,1151694 ! response to cAMP GO:0051591 19 14 0,000 0,07571136 0,11509328 ! startle response GO:0001964 21 14 0,000 0,07571136 0,11501727 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,07571136 0,11494135 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,07571136 0,11486553 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,07571136 0,11478981 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,07571136 0,11471419 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,07571136 0,11463867 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,07571136 0,11456325 ! glycine metabolic process GO:0006544 22 14 0,000 0,07571136 0,11448793 ! cellular response to starvation GO:0009267 21 14 0,000 0,07571136 0,11441271 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,07571136 0,11433758 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,07571136 0,11426256 ! regulation of heart rate GO:0002027 23 14 0,000 0,07571136 0,11418763 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,07571136 0,1141128 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,07571136 0,11403807 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,07571136 0,11396344 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,07571136 0,11388891 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,07571136 0,11381447 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! axon cargo transport GO:0008088 27 14 0,000 0,07571136 0,11374013 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,07571136 0,11366589 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,07571136 0,11359174 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,07571136 0,11351769 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,07571136 0,11344374 ! mRNA splice site selection GO:0006376 26 14 0,000 0,07571136 0,11336988 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,07571136 0,11329612 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,07571136 0,11322246 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,07571136 0,11314889 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,07571136 0,11307542 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,07571136 0,11300204 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,07571136 0,11292875 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,07571136 0,11285557 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,07571136 0,11278247 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,07571136 0,11270948 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,07571136 0,11263657 ! cell killing GO:0001906 20 14 0,000 0,07571136 0,11256376 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,07571136 0,11249105 ! cilium assembly GO:0042384 20 14 0,000 0,07571136 0,11241842 ! hemostasis GO:0007599 125 81 1,000 0,07579461 0,11246942 ! ossification GO:0001503 134 82 1,000 0,07741475 0,11479944 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,07741475 0,11472547 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,07904585 0,11706726 ! regulation of defense response GO:0031347 117 84 1,000 0,08068773 0,11942199 ! sterol metabolic process GO:0016125 120 84 1,000 0,08068773 0,11934519 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,08089686 0,11957763 ! metencephalon development GO:0022037 19 15 0,000 0,08089686 0,11950083 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08089686 0,11942412 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,08089686 0,11934752 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08089686 0,11927102 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08089686 0,11919461 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08089686 0,1191183 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08089686 0,11904209 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08089686 0,11896598 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08089686 0,11888996 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08089686 0,11881404 ! adult walking behavior GO:0007628 25 15 0,000 0,08089686 0,11873822 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08089686 0,11866249 ! myoblast differentiation GO:0045445 27 15 0,000 0,08089686 0,11858686 ! centrosome cycle GO:0007098 16 15 0,000 0,08089686 0,11851133 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,08089686 0,11843589 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08089686 0,11836055 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08089686 0,11828531 ! response to osmotic stress GO:0006970 22 15 0,000 0,08089686 0,11821016 ! vesicle coating GO:0006901 25 15 0,000 0,08089686 0,1181351 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,08089686 0,11806014 ! DNA integration GO:0015074 22 15 0,000 0,08089686 0,11798528 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,08089686 0,11791051 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08089686 0,11783584 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08089686 0,11776126 ! neuron recognition GO:0008038 22 15 0,000 0,08089686 0,11768677 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08089686 0,11761238 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,08089686 0,11753808 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,08089686 0,11746388 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08089686 0,11738977 ! biomineral formation GO:0031214 18 15 0,000 0,08089686 0,11731575 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08089686 0,11724183 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08089686 0,117168 ! dopamine metabolic process GO:0042417 30 15 0,000 0,08089686 0,11709426 ! organic cation transport GO:0015695 19 15 0,000 0,08089686 0,11702062 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08089686 0,11694707 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,08089686 0,11687361 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,08089686 0,11680024 ! peptide hormone processing GO:0016486 19 15 0,000 0,08089686 0,11672697 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,08089686 0,11665378 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,08234022 0,11866071 ! transcription initiation GO:0006352 118 85 1,000 0,08234022 0,11858641 ! cellular defense response GO:0006968 102 87 1,000 0,08567637 0,12331392 ! female pregnancy GO:0007565 130 87 1,000 0,08567637 0,1232368 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,08567637 0,12315978 ! protein secretion GO:0009306 27 16 0,000 0,08605356 0,12362473 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,08605356 0,12354757 ! bone remodeling GO:0046849 24 16 0,000 0,08605356 0,12347049 ! endothelial cell migration GO:0043542 22 16 0,000 0,08605356 0,12339352 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,08605356 0,12331664 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08605356 0,12323985 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,08605356 0,12316316 ! patterning of blood vessels GO:0001569 24 16 0,000 0,08605356 0,12308657 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,08605356 0,12301007 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,08605356 0,12293366 ! protein polyubiquitination GO:0000209 26 16 0,000 0,08605356 0,12285736 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,08605356 0,12278114 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,08605356 0,12270502 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,08605356 0,122629 ! regulation of protein binding GO:0043393 27 16 0,000 0,08605356 0,12255306 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,08605356 0,12247723 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,08605356 0,12240148 ! protein export from nucleus GO:0006611 24 16 0,000 0,08605356 0,12232583 ! negative regulation of immune response GO:0050777 28 16 0,000 0,08605356 0,12225028 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,08605356 0,12217481 ! DNA replication initiation GO:0006270 25 16 0,000 0,08605356 0,12209944 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,08605356 0,12202417 ! oogenesis GO:0048477 23 16 0,000 0,08605356 0,12194898 ! neural crest cell migration GO:0001755 24 16 0,000 0,08605356 0,12187389 ! G1 phase GO:0051318 27 16 0,000 0,08605356 0,12179889 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,08605356 0,12172398 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,08605356 0,12164917 ! steroid catabolic process GO:0006706 22 16 0,000 0,08605356 0,12157445 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,08605356 0,12149982 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,08605356 0,12142528 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,08605356 0,12135083 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,08605356 0,12127647 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,08605356 0,1212022 ! sperm-egg recognition GO:0035036 16 16 0,000 0,08605356 0,12112803 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,08605356 0,12105394 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,08605356 0,12097995 ! negative regulation of translation GO:0017148 22 16 0,000 0,08605356 0,12090605 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,0873597 0,12266624 ! reproductive developmental process GO:0003006 127 89 1,000 0,08905298 0,12496757 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,09075605 0,12727982 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,09118163 0,12779875 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,09118163 0,12772092 ! negative regulation of defense response GO:0031348 19 17 0,000 0,09118163 0,12764318 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,09118163 0,12756554 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,09118163 0,12748799 ! glycerol metabolic process GO:0006071 20 17 0,000 0,09118163 0,12741054 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,09118163 0,12733318 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,09118163 0,12725591 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,09118163 0,12717874 ! signal complex assembly GO:0007172 29 17 0,000 0,09118163 0,12710166 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,09118163 0,12702468 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,09118163 0,12694779 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,09118163 0,12687099 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,09118163 0,12679428 ! memory GO:0007613 25 17 0,000 0,09118163 0,12671767 ! keratinization GO:0031424 17 17 0,000 0,09118163 0,12664115 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,09118163 0,12656472 ! retinoid metabolic process GO:0001523 22 17 0,000 0,09118163 0,12648839 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,09118163 0,12641214 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,09118163 0,12633599 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,09118163 0,12625993 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,09118163 0,12618396 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,09118163 0,12610808 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,09118163 0,1260323 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,09118163 0,1259566 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,09118163 0,125881 ! membrane budding GO:0006900 29 17 0,000 0,09118163 0,12580549 ! heme metabolic process GO:0042168 27 17 0,000 0,09118163 0,12573006 ! actin filament bundle formation GO:0051017 26 17 0,000 0,09118163 0,12565473 ! body fluid secretion GO:0007589 27 17 0,000 0,09118163 0,12557949 ! stem cell differentiation GO:0048863 36 17 0,000 0,09118163 0,12550434 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,09118163 0,12542927 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,09118163 0,1253543 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,09118163 0,12527942 ! sensory perception of pain GO:0019233 23 17 0,000 0,09118163 0,12520462 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,09118163 0,12512992 ! synaptogenesis GO:0007416 24 17 0,000 0,09118163 0,1250553 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,09118163 0,12498078 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,09118163 0,12490634 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,09118163 0,12483199 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,09118163 0,12475773 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,09118163 0,12468356 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,09118163 0,12460947 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,09118163 0,12453548 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,09118163 0,12446157 ! response to virus GO:0009615 122 91 1,000 0,09246875 0,12614361 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,09419092 0,12841678 ! positive regulation of immune response GO:0050778 121 92 1,000 0,09419092 0,12834071 ! sulfur metabolic process GO:0006790 118 92 1,000 0,09419092 0,12826472 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,09628121 0,1310336 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,09628121 0,13095611 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,09628121 0,13087871 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,09628121 0,13080141 ! cAMP metabolic process GO:0046058 33 18 0,000 0,09628121 0,13072419 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,09628121 0,13064707 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,09628121 0,13057004 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,09628121 0,1304931 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,09628121 0,13041624 GO:0050886|endocrine process, ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,09628121 0,13033948 ! glutamine metabolic process GO:0006541 23 18 0,000 0,09628121 0,13026281 ! response to retinoic acid GO:0032526 25 18 0,000 0,09628121 0,13018623 ! pigmentation during development GO:0048066 31 18 0,000 0,09628121 0,13010974 ! central nervous system neuron development GO:0021954 30 18 0,000 0,09628121 0,13003334 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,09628121 0,12995703 ! fucose metabolic process GO:0006004 26 18 0,000 0,09628121 0,12988081 ! response to fungus GO:0009620 19 18 0,000 0,09628121 0,12980468 ! peptide cross-linking GO:0018149 31 18 0,000 0,09628121 0,12972864 ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,09628121 0,12965268 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,09628121 0,12957682 ! visual learning GO:0008542 35 18 0,000 0,09628121 0,12950104 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,09628121 0,12942536 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,09628121 0,12934976 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,09628121 0,12927425 ! vitamin transport GO:0051180 24 18 0,000 0,09628121 0,12919882 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,09628121 0,12912349 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,09628121 0,12904824 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,09628121 0,12897308 ! cell-cell recognition GO:0009988 20 18 0,000 0,09628121 0,12889801 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,09628121 0,12882303 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,09628121 0,12874813 ! regulation of glucose import GO:0046324 21 18 0,000 0,09628121 0,12867332 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,09628121 0,1285986 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,09628121 0,12852396 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,09628121 0,12844941 ! electron transport chain GO:0022900 123 94 1,000 0,09766304 0,13021739 ! response to oxidative stress GO:0006979 141 94 1,000 0,09766304 0,13014195 ! angiogenesis GO:0001525 149 95 1,000 0,09941269 0,13239675 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,10117118 0,13466072 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,10117118 0,13458283 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,10117118 0,13450504 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10135247 0,13466821 ! positive regulation of ossification GO:0045778 30 19 0,000 0,10135247 0,13459046 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10135247 0,1345128 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,10135247 0,13443522 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,10135247 0,13435774 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,10135247 0,13428034 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,10135247 0,13420304 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10135247 0,13412582 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10135247 0,13404869 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,10135247 0,13397165 ! response to alkaloid GO:0043279 32 19 0,000 0,10135247 0,1338947 ! sensory perception of taste GO:0050909 23 19 0,000 0,10135247 0,13381784 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,10135247 0,13374106 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10135247 0,13366438 ! peroxisome organization GO:0007031 29 19 0,000 0,10135247 0,13358778 ! digestive system process GO:0022600 30 19 0,000 0,10135247 0,13351127 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,10135247 0,13343485 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10135247 0,13335851 ! response to vitamin A GO:0033189 26 19 0,000 0,10135247 0,13328226 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10135247 0,1332061 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,10135247 0,13313003 ! response to starvation GO:0042594 30 19 0,000 0,10135247 0,13305404 ! sex determination GO:0007530 29 19 0,000 0,10135247 0,13297814 ! plasma membrane fusion GO:0045026 23 19 0,000 0,10135247 0,13290232 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,10135247 0,1328266 ! cytolysis GO:0019835 20 19 0,000 0,10135247 0,13275095 ! renal system process GO:0003014 35 19 0,000 0,10135247 0,1326754 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,10135247 0,13259993 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,10135247 0,13252455 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,10135247 0,13244925 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10135247 0,13237404 ! sarcomere organization GO:0045214 23 19 0,000 0,10135247 0,13229891 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10135247 0,13222387 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,10135247 0,13214891 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10135247 0,13207404 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,10135247 0,13199925 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10135247 0,13192455 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,10135247 0,13184993 ! protein stabilization GO:0050821 26 19 0,000 0,10135247 0,1317754 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,10293837 0,13376173 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,10293837 0,1336862 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,10639556 0,13809807 ! iron ion transport GO:0006826 37 20 0,000 0,10639556 0,13802018 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,10639556 0,13794238 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,10639556 0,13786466 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,10639556 0,13778704 ! response to vitamin GO:0033273 29 20 0,000 0,10639556 0,1377095 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,10639556 0,13763205 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,10639556 0,13755468 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,10639556 0,1374774 ! spinal cord development GO:0021510 31 20 0,000 0,10639556 0,13740021 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,10639556 0,13732311 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,10639556 0,13724609 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,10639556 0,13716916 ! chromosome condensation GO:0030261 31 20 0,000 0,10639556 0,13709231 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,10639556 0,13701555 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,10639556 0,13693888 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,10639556 0,13686229 ! DNA modification GO:0006304 28 20 0,000 0,10639556 0,13678579 ! collagen fibril organization GO:0030199 45 20 0,000 0,10639556 0,13670937 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,10639556 0,13663304 ! collagen catabolic process GO:0030574 25 20 0,000 0,10639556 0,1365568 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,10639556 0,13648064 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,10639556 0,13640456 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,10639556 0,13632857 ! alditol metabolic process GO:0019400 24 20 0,000 0,10639556 0,13625266 ! actin filament-based movement GO:0030048 34 20 0,000 0,10639556 0,13617684 ! extracellular structure organization GO:0043062 156 99 1,000 0,10649825 0,13623247 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,10829065 0,1384483 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,10829065 0,13837138 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,11141063 0,14227898 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,11141063 0,14220003 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,11141063 0,14212116 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,11141063 0,14204238 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,11141063 0,14196369 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,11141063 0,14188508 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,11141063 0,14180656 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,11141063 0,14172813 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,11141063 0,14164978 ! vesicle docking GO:0048278 27 21 0,000 0,11141063 0,14157152 ! phototransduction GO:0007602 25 21 0,000 0,11141063 0,14149335 ! dendrite development GO:0016358 35 21 0,000 0,11141063 0,14141526 ! visual behavior GO:0007632 39 21 0,000 0,11141063 0,14133726 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,11141063 0,14125934 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,11141063 0,14118152 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,11141063 0,14110377 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,11141063 0,14102612 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,11141063 0,14094854 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,11141063 0,14087106 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,11141063 0,14079365 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,11141063 0,14071634 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,11141063 0,14063911 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,11141063 0,14056196 ! fatty acid transport GO:0015908 30 21 0,000 0,11141063 0,1404849 ! immunoglobulin production GO:0002377 33 21 0,000 0,11141063 0,14040792 GO:0002440|production of molecular mediator of immune response, ! regulation of bone mineralization GO:0030500 29 21 0,000 0,11141063 0,14033103 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,11141063 0,14025422 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,11141063 0,14017749 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,11141063 0,14010085 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,11141063 0,14002429 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,11141063 0,13994782 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,11141063 0,13987143 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,11141063 0,13979512 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,11141063 0,13971889 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,11639785 0,14589376 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,11639785 0,1458143 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,11639785 0,14573492 ! leukocyte adhesion GO:0007159 38 22 0,000 0,11639785 0,14565563 ! molting cycle process GO:0022404 40 22 0,000 0,11639785 0,14557643 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,11639785 0,14549731 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,11639785 0,14541828 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,11639785 0,14533933 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,11639785 0,14526047 ! vasculogenesis GO:0001570 33 22 0,000 0,11639785 0,1451817 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,11639785 0,14510301 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,11639785 0,1450244 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,11639785 0,14494588 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,11639785 0,14486745 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,11639785 0,1447891 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,11639785 0,14471084 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,11639785 0,14463266 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,11639785 0,14455456 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,11639785 0,14447655 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,11639785 0,14439862 ! membrane depolarization GO:0051899 35 22 0,000 0,11639785 0,14432078 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,11639785 0,14424302 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,11639785 0,14416535 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,11639785 0,14408775 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,11639785 0,14401025 ! blastocyst development GO:0001824 37 22 0,000 0,11639785 0,14393282 ! neural tube closure GO:0001843 33 22 0,000 0,11639785 0,14385548 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein tetramerization GO:0051262 39 22 0,000 0,11639785 0,14377822 ! neuron fate commitment GO:0048663 32 23 0,000 0,12135735 0,14982389 ! embryonic pattern specification GO:0009880 31 23 0,000 0,12135735 0,14974352 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,12135735 0,14966322 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,12135735 0,14958302 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,12135735 0,1495029 ! vesicle targeting GO:0006903 32 23 0,000 0,12135735 0,14942287 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,12135735 0,14934292 ! osteoblast differentiation GO:0001649 40 23 0,000 0,12135735 0,14926306 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,12135735 0,14918328 ! interaction with host GO:0051701 37 23 0,000 0,12135735 0,14910359 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,12135735 0,14902398 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,12135735 0,14894446 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,12135735 0,14886502 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,12135735 0,14878567 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,12135735 0,1487064 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,12135735 0,14862722 ! cell fate determination GO:0001709 45 23 0,000 0,12135735 0,14854812 ! pentose metabolic process GO:0019321 31 23 0,000 0,12135735 0,1484691 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,12135735 0,14839017 ! spermatid development GO:0007286 33 23 0,000 0,12135735 0,14831133 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,12135735 0,14823256 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,12135735 0,14815388 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,12135735 0,14807529 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,12135735 0,14799677 ! telomere organization GO:0032200 32 23 0,000 0,12135735 0,14791834 GO:0000723|telomere maintenance, ! regulation of amine transport GO:0051952 38 23 0,000 0,12135735 0,14784 ! liver development GO:0001889 40 23 0,000 0,12135735 0,14776173 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,12628931 0,1536854 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,12628931 0,15360413 ! initiation of viral infection GO:0019059 42 24 0,000 0,12628931 0,15352294 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,12628931 0,15344184 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,12628931 0,15336083 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,12628931 0,1532799 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,12628931 0,15319905 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,12628931 0,1531183 ! sperm motility GO:0030317 27 24 0,000 0,12628931 0,15303762 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,12628931 0,15295703 ! vacuole organization GO:0007033 39 24 0,000 0,12628931 0,15287653 ! receptor metabolic process GO:0043112 37 24 0,000 0,12628931 0,15279611 ! neural crest cell development GO:0014032 39 24 0,000 0,12628931 0,15271578 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,12628931 0,15263553 ! primary neural tube formation GO:0014020 35 24 0,000 0,12628931 0,15255536 ! base-excision repair GO:0006284 31 24 0,000 0,12628931 0,15247528 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,12628931 0,15239528 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,13119386 0,15823066 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,13119386 0,15814773 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,13119386 0,15806489 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,13119386 0,15798213 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,13119386 0,15789946 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,13119386 0,15781688 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,13119386 0,15773438 ! male gonad development GO:0008584 33 25 0,000 0,13119386 0,15765197 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,13119386 0,15756965 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,13119386 0,15748741 ! phospholipid transport GO:0015914 35 25 0,000 0,13119386 0,15740526 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,13119386 0,15732319 ! detection of light stimulus GO:0009583 30 25 0,000 0,13119386 0,15724121 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,13119386 0,15715931 ! leukocyte proliferation GO:0070661 39 25 0,000 0,13119386 0,1570775 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,13607116 0,16283229 ! regulation of pH GO:0006885 36 26 0,000 0,13607116 0,16274761 ! circadian rhythm GO:0007623 42 26 0,000 0,13607116 0,16266303 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,13607116 0,16257853 ! post-embryonic development GO:0009791 42 26 0,000 0,13607116 0,16249411 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,13607116 0,16240979 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,13607116 0,16232555 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,13607116 0,1622414 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,13607116 0,16215734 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,13607116 0,16207336 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,13607116 0,16198947 ! regulation of coagulation GO:0050818 39 26 0,000 0,13607116 0,16190567 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,14092135 0,16759003 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,14092135 0,16750342 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,14092135 0,1674169 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,14092135 0,16733047 ! membrane docking GO:0022406 39 27 0,000 0,14092135 0,16724412 ! catechol metabolic process GO:0009712 43 27 0,000 0,14092135 0,16715787 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,14092135 0,16707171 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,14092135 0,16698563 ! myofibril assembly GO:0030239 36 27 0,000 0,14092135 0,16689965 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,14092135 0,16681375 ! response to ionizing radiation GO:0010212 47 27 0,000 0,14092135 0,16672794 ! natural killer cell activation GO:0030101 35 27 0,000 0,14092135 0,16664222 ! lipid oxidation GO:0034440 38 27 0,000 0,14092135 0,16655658 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,14092135 0,16647104 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,14092135 0,16638558 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,14092135 0,16630021 GO:0043433|negative regulation of transcription factor activity, ! gene silencing GO:0016458 41 27 0,000 0,14092135 0,16621493 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,1457446 0,17181577 ! phenol metabolic process GO:0018958 44 28 0,000 0,1457446 0,17172775 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,1457446 0,17163982 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,1457446 0,17155198 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,1457446 0,17146423 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,1457446 0,17137657 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,1457446 0,171289 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,1457446 0,17120152 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,1457446 0,17111413 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,1457446 0,17102682 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,1457446 0,17093961 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,1457446 0,17085248 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,1457446 0,17076545 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,1457446 0,1706785 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,1457446 0,17059164 ! mesoderm formation GO:0001707 46 28 0,000 0,1457446 0,17050487 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,1457446 0,17041819 ! BMP signaling pathway GO:0030509 40 28 0,000 0,1457446 0,17033159 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,1457446 0,17024508 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,1457446 0,17015867 ! neural tube formation GO:0001841 41 28 0,000 0,1457446 0,17007233 ! regulation of innate immune response GO:0045088 38 29 0,000 0,15054103 0,17558031 ! protein targeting to membrane GO:0006612 53 29 0,000 0,15054103 0,17549132 ! mismatch repair GO:0006298 34 29 0,000 0,15054103 0,17540242 ! muscle cell development GO:0055001 38 29 0,000 0,15054103 0,17531361 ! formation of primary germ layer GO:0001704 48 29 0,000 0,15054103 0,17522489 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,15054103 0,17513626 ! eye morphogenesis GO:0048592 51 29 0,000 0,15054103 0,17504771 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,15054103 0,17495926 ! collagen metabolic process GO:0032963 40 30 0,000 0,15531082 0,18041155 ! organic anion transport GO:0015711 51 30 0,000 0,15531082 0,18032048 ! cholesterol transport GO:0030301 46 30 0,000 0,15531082 0,1802295 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,15531082 0,18013862 ! spindle organization GO:0007051 37 30 0,000 0,15531082 0,18004782 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,15531082 0,17995712 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,15531082 0,1798665 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,15531082 0,17977598 ! ceramide metabolic process GO:0006672 43 30 0,000 0,15531082 0,17968555 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,15531082 0,17959521 ! adult locomotory behavior GO:0008344 47 30 0,000 0,15531082 0,17950496 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,15531082 0,1794148 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,15531082 0,17932474 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,15531082 0,17923476 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,16005408 0,18461605 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,16005408 0,18452351 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,16005408 0,18443106 ! odontogenesis GO:0042476 50 31 0,000 0,16005408 0,18433871 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,16005408 0,18424644 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,16005408 0,18415427 ! metanephros development GO:0001656 58 31 0,000 0,16005408 0,1840622 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,16005408 0,18397021 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,16005408 0,18387832 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,16005408 0,18378652 ! cell fate specification GO:0001708 37 31 0,000 0,16005408 0,18369481 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,16005408 0,18360319 ! RNA modification GO:0009451 40 31 0,000 0,16005408 0,18351166 ! regulation of muscle development GO:0048634 48 32 0,000 0,16477099 0,18882575 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,16477099 0,18873171 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,16477099 0,18863777 ! meiosis I GO:0007127 52 32 0,000 0,16477099 0,18854392 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,16477099 0,18845016 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,16477099 0,1883565 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,16477099 0,18826293 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,16477099 0,18816945 ! regulation of protein stability GO:0031647 48 32 0,000 0,16477099 0,18807607 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,16477099 0,18798278 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,16477099 0,18788958 ! vesicle localization GO:0051648 47 32 0,000 0,16477099 0,18779647 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,16946167 0,19304698 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,16946167 0,19295141 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,16946167 0,19285594 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,16946167 0,19276056 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,16946167 0,19266527 ! sister chromatid segregation GO:0000819 46 33 0,000 0,16946167 0,19257008 ! actomyosin structure organization GO:0031032 43 33 0,000 0,16946167 0,19247499 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,16946167 0,19237998 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,16946167 0,19228508 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,16946167 0,19219026 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,16946167 0,19209554 ! positive regulation of cell development GO:0010720 54 33 0,000 0,16946167 0,19200091 ! lipid homeostasis GO:0055088 55 33 0,000 0,16946167 0,19190638 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,16946167 0,19181193 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,16946167 0,19171758 ! cytokinesis GO:0000910 52 33 0,000 0,16946167 0,19162333 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,16946167 0,19152916 ! mRNA catabolic process GO:0006402 48 34 0,000 0,17412628 0,19670454 ! feeding behavior GO:0007631 45 34 0,000 0,17412628 0,19660798 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,17412628 0,19651151 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,17412628 0,19641513 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,17412628 0,19631885 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,17412628 0,19622266 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,17412628 0,19612657 ! neuron migration GO:0001764 46 34 0,000 0,17412628 0,19603057 ! female gamete generation GO:0007292 43 34 0,000 0,17412628 0,19593466 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,17412628 0,19583885 ! polyol metabolic process GO:0019751 44 34 0,000 0,17412628 0,19574313 ! aerobic respiration GO:0009060 47 34 0,000 0,17412628 0,19564751 ! embryonic organ development GO:0048568 45 34 0,000 0,17412628 0,19555198 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,17876496 0,20066345 ! Notch signaling pathway GO:0007219 56 35 0,000 0,17876496 0,20056556 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,17876496 0,20046777 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,17876496 0,20037008 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,17876496 0,20027248 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,17876496 0,20017498 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,17876496 0,20007757 ! glycogen metabolic process GO:0005977 48 35 0,000 0,17876496 0,19998026 ! pigment metabolic process GO:0042440 61 35 0,000 0,17876496 0,19988304 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,18337785 0,20494123 ! organic ether metabolic process GO:0018904 46 36 0,000 0,18337785 0,20484169 ! tissue remodeling GO:0048771 62 36 0,000 0,18337785 0,20474225 ! neural tube development GO:0021915 50 36 0,000 0,18337785 0,20464291 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,18337785 0,20454367 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,18337785 0,20444452 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,18337785 0,20434547 ! glucan metabolic process GO:0044042 49 36 0,000 0,18337785 0,20424651 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,18796508 0,20925445 GO:0006956|complement activation, ! learning GO:0007612 67 37 0,000 0,18796508 0,20915321 ! ion transmembrane transport GO:0034220 56 37 0,000 0,18796508 0,20905208 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,18796508 0,20895104 ! amino acid activation GO:0043038 52 37 0,000 0,18796508 0,20885009 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,18796508 0,20874925 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,19252682 0,2137122 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,19252682 0,21360911 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,19252682 0,21350611 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,19252682 0,21340322 ! phagocytosis GO:0006909 60 38 0,000 0,19252682 0,21330042 ! mesenchymal cell development GO:0014031 64 38 0,000 0,19252682 0,21319773 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,19252682 0,21309513 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,19706318 0,21801122 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,19706318 0,2179064 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,19706318 0,21780169 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,19706318 0,21769708 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,19706318 0,21759257 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,19706318 0,21748816 ! male sex differentiation GO:0046661 53 39 0,000 0,19706318 0,21738385 ! chromatin remodeling GO:0006338 68 39 0,000 0,19706318 0,21727964 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,19706318 0,21717552 ! developmental growth GO:0048589 62 39 0,000 0,19706318 0,21707151 ! cell growth GO:0016049 61 39 0,000 0,19706318 0,2169676 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,20157432 0,2218282 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,20157432 0,22172211 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,20157432 0,22161613 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,20606037 0,22643997 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,20606037 0,22633183 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,20606037 0,2262238 ! endosome transport GO:0016197 71 41 0,000 0,20606037 0,22611587 ! striated muscle contraction GO:0006941 62 41 0,000 0,20606037 0,22600804 ! biopolymer methylation GO:0043414 62 41 0,000 0,20606037 0,22590031 ! mitochondrial transport GO:0006839 60 42 0,000 0,21052148 0,23068099 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,21052148 0,23057114 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,21052148 0,2304614 ! excretion GO:0007588 63 42 0,000 0,21052148 0,23035176 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,21052148 0,23024222 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,21052148 0,23013279 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,21052148 0,23002347 ! regulation of cell shape GO:0008360 78 42 0,000 0,21052148 0,22991424 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,21495777 0,23464778 ! neuromuscular process GO:0050905 79 43 0,000 0,21495777 0,23453646 ! activation of caspase activity GO:0006919 65 43 0,000 0,21495777 0,23442525 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,21495777 0,23431415 ! tRNA processing GO:0008033 49 43 0,000 0,21495777 0,23420316 ! vesicle organization GO:0016050 79 43 0,000 0,21495777 0,23409226 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,21495777 0,23398148 ! methylation GO:0032259 64 43 0,000 0,21495777 0,2338708 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,21936938 0,23855772 ! glycolysis GO:0006096 53 44 0,000 0,21936938 0,23844498 ! regulation of ion transport GO:0043269 57 44 0,000 0,21936938 0,23833235 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,21936938 0,23821982 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,21936938 0,2381074 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,21936938 0,23799508 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,21936938 0,23788287 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,21936938 0,23777077 ! RNA catabolic process GO:0006401 64 45 0,000 0,22375645 0,24241161 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,22375645 0,24229748 ! cell recognition GO:0008037 58 45 0,000 0,22375645 0,24218346 ! cell maturation GO:0048469 60 45 0,000 0,22375645 0,24206954 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,22811912 0,24667324 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,22811912 0,24655732 ! cell redox homeostasis GO:0045454 63 46 0,000 0,22811912 0,24644151 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,22811912 0,24632581 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,23245752 0,25089268 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,23245752 0,250775 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,23245752 0,25065743 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,23245752 0,25053997 ! chloride transport GO:0006821 67 48 0,000 0,23677179 0,25507031 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,23677179 0,25495089 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,23677179 0,25483159 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,23677179 0,2547124 ! gastrulation GO:0007369 73 48 0,000 0,23677179 0,25459332 ! heart morphogenesis GO:0003007 65 48 0,000 0,23677179 0,25447435 ! regulation of DNA replication GO:0006275 75 48 0,000 0,23677179 0,25435549 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,23677179 0,25423674 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,23677179 0,25411811 ! regulation of endocytosis GO:0030100 63 48 0,000 0,23677179 0,25399958 ! nuclear export GO:0051168 69 48 0,000 0,23677179 0,25388117 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,24106204 0,258361 ! sensory perception of smell GO:0007608 61 49 0,000 0,24106204 0,25824066 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,24106204 0,25812044 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,24106204 0,25800033 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,24106204 0,25788033 ! germ cell development GO:0007281 68 49 0,000 0,24106204 0,25776044 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,24106204 0,25764066 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,24106204 0,25752099 ! cartilage development GO:0051216 70 49 0,000 0,24106204 0,25740144 ! regulation of actin filament length GO:0030832 72 50 0,000 0,24532843 0,26183545 ! membrane fusion GO:0006944 80 50 0,000 0,24532843 0,261714 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,24532843 0,26159267 ! proton transport GO:0015992 75 50 0,000 0,24532843 0,26147145 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,24532843 0,26135034 ! hydrogen transport GO:0006818 77 51 0,000 0,24957108 0,26574698 ! adult behavior GO:0030534 80 51 0,000 0,24957108 0,26562401 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,24957108 0,26550115 ! regulation of cellular component size GO:0032535 74 52 0,000 0,25379011 0,26986466 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,25379011 0,26973995 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,25379011 0,26961536 ! establishment of organelle localization GO:0051656 85 52 0,000 0,25379011 0,26949089 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,25798567 0,27381959 ! kidney development GO:0001822 90 53 0,000 0,25798567 0,27369329 ! single fertilization GO:0007338 59 53 0,000 0,25798567 0,2735671 ! amino acid transport GO:0006865 84 54 0,000 0,26215788 0,27786319 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,26215788 0,2777352 ! glucose catabolic process GO:0006007 66 54 0,000 0,26215788 0,27760733 ! detection of external stimulus GO:0009581 66 54 0,000 0,26215788 0,27747958 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,26215788 0,27735194 ! exocytosis GO:0006887 74 55 0,000 0,26630687 0,28161186 ! mesoderm development GO:0007498 76 55 0,000 0,26630687 0,28148244 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,26630687 0,28135314 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,26630687 0,28122396 ! chromosome segregation GO:0007059 83 57 0,000 0,27453568 0,28978067 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,27453568 0,28964774 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,27453568 0,28951493 ! secondary metabolic process GO:0019748 84 57 0,000 0,27453568 0,28938225 ! developmental maturation GO:0021700 75 57 0,000 0,27453568 0,28924969 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,27861577 0,29341404 ! actin filament organization GO:0007015 95 59 0,000 0,28267314 0,29755068 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,28267314 0,29741456 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,28267314 0,29727857 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,28670793 0,30138402 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,28670793 0,30124634 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,28670793 0,30110878 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,28670793 0,30097135 ! regulation of heart contraction GO:0008016 91 60 0,000 0,28670793 0,30083405 ! fertilization GO:0009566 68 60 0,000 0,28670793 0,30069687 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,28670793 0,30055981 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,29072024 0,30462714 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,29072024 0,30448842 ! urogenital system development GO:0001655 101 61 0,000 0,29072024 0,30434982 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,29072024 0,30421136 ! extracellular matrix organization GO:0030198 103 61 0,000 0,29072024 0,30407302 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,29072024 0,3039348 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,29072024 0,30379671 ! amine catabolic process GO:0009310 90 62 0,000 0,29471022 0,3078263 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,29471022 0,30768657 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,29471022 0,30754697 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,29471022 0,30740749 ! organelle localization GO:0051640 96 62 0,000 0,29471022 0,30726814 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,29867798 0,31126387 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,30262365 0,31523297 ! appendage morphogenesis GO:0035107 93 64 0,000 0,30262365 0,31509027 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,30262365 0,31494769 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,30262365 0,31480524 ! hexose catabolic process GO:0019320 82 64 0,000 0,30262365 0,31466293 ! appendage development GO:0048736 94 65 0,000 0,30654734 0,31859868 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,30654734 0,31845478 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,30654734 0,31831101 ! activation of immune response GO:0002253 83 65 0,000 0,30654734 0,31816737 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,31044918 0,32207177 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,31044918 0,32192657 ! antigen processing and presentation GO:0019882 96 66 0,000 0,31044918 0,32178149 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,31818779 0,32965402 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,31818779 0,32950559 ! inorganic anion transport GO:0015698 93 68 0,000 0,31818779 0,3293573 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,32202479 0,33317905 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,32202479 0,33302924 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,32202479 0,33287956 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,32584043 0,3366725 ! amine transport GO:0015837 101 70 0,000 0,32584043 0,33652132 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,32584043 0,33637028 ! muscle cell differentiation GO:0042692 104 71 0,000 0,3296348 0,34013461 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,3296348 0,33998208 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,3296348 0,33982969 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,3296348 0,33967744 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,33340803 0,34341177 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,33340803 0,34325805 ! tube morphogenesis GO:0035239 118 73 0,000 0,33716025 0,3469658 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,33716025 0,34681063 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,34089155 0,35049198 ! digestion GO:0007586 97 74 0,000 0,34089155 0,35033537 ! protein import into nucleus GO:0006606 118 74 0,000 0,34089155 0,3501789 ! response to nutrient GO:0007584 104 75 0,000 0,34460207 0,35383248 ! regulation of ligase activity GO:0051340 114 75 0,000 0,34460207 0,35367459 ! nuclear import GO:0051170 121 75 0,000 0,34460207 0,35351684 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,34460207 0,35335923 ! amine biosynthetic process GO:0009309 97 76 0,000 0,3482919 0,35698368 ! tRNA metabolic process GO:0006399 95 76 0,000 0,3482919 0,35682467 ! response to unfolded protein GO:0006986 99 76 0,000 0,3482919 0,3566658 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,35196118 0,36026289 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,35196118 0,36010263 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,35196118 0,35994251 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,35196118 0,35978254 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,35561 0,36335096 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,35561 0,36318961 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,35923849 0,36673259 ! regulation of lyase activity GO:0051339 133 79 0,000 0,35923849 0,36656989 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,35923849 0,36640733 ! chromatin assembly GO:0031497 102 80 0,000 0,36284676 0,36992355 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,36284676 0,36975965 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,36284676 0,3695959 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,36284676 0,36943229 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,36284676 0,36926882 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,36643491 0,37275555 ! mRNA transport GO:0051028 121 81 0,000 0,36643491 0,37259075 ! response to protein stimulus GO:0051789 111 81 0,000 0,36643491 0,37242611 ! regulation of neurological system process GO:0031644 122 81 0,000 0,36643491 0,37226161 ! vitamin metabolic process GO:0006766 103 81 0,000 0,36643491 0,37209726 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,37355132 0,37915623 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,37355132 0,37898898 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,37707979 0,38240014 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,37707979 0,38223161 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,3805886 0,3856184 ! rRNA metabolic process GO:0016072 107 85 0,000 0,3805886 0,3854486 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,38407784 0,38881119 ! nucleosome organization GO:0034728 114 87 0,000 0,38754762 0,39215114 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,38754762 0,39197869 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,39099806 0,39529474 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,39099806 0,39512106 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,39099806 0,39494753 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,39099806 0,39477416 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,39442925 0,39806375 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,39442925 0,39788916 ! hormone metabolic process GO:0042445 121 90 0,000 0,39784131 0,4011552 ! RNA localization GO:0006403 135 91 0,000 0,40123434 0,4043992 ! ATP metabolic process GO:0046034 137 91 0,000 0,40123434 0,40422207 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,40460844 0,40744283 ! cell fate commitment GO:0045165 141 92 0,000 0,40460844 0,40726452 ! DNA recombination GO:0006310 146 92 0,000 0,40460844 0,40708636 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,40796373 0,41028272 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,40796373 0,4101034 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,40796373 0,40992423 ! carboxylic acid transport GO:0046942 147 95 0,000 0,41461825 0,41642881 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,41791769 0,41955944 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,41791769 0,41937639 ! protein maturation GO:0051604 129 96 0,000 0,41791769 0,4191935 ! calcium ion transport GO:0006816 167 99 0,000 0,42770597 0,42882465 ! protein import GO:0017038 156 99 0,000 0,42770597 0,4286378 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,43093239 0,43168314 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,43093239 0,43149521 ! divalent metal ion transport GO:0070838 171 100 0,000 0,43093239 0,43130744 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,43093239 0,43111983 ! protein localization in organelle GO:0033365 161 100 0,000 0,43093239 0,43093239