pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6851-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 13 6 3,000 5,457E-09 1,333E-05 ! establishment of nucleus localization GO:0040023 18 8 3,000 2,529E-08 3,089E-05 ! insulin receptor signaling pathway GO:0008286 66 27 4,000 1,177E-07 9,585E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 3,000 1,18E-07 7,207E-05 ! nucleus localization GO:0051647 22 11 3,000 1,18E-07 5,766E-05 ! epithelial to mesenchymal transition GO:0001837 30 15 3,000 4,814E-07 1,96E-04 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 7,037E-07 2,456E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 1,674E-06 5,113E-04 GO:0031272|regulation of pseudopodium assembly, ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 1,868E-06 5,07E-04 ! response to insulin stimulus GO:0032868 98 47 4,000 2,083E-06 5,088E-04 ! cellular response to hormone stimulus GO:0032870 182 85 5,000 2,213E-06 4,914E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 2,921E-06 5,946E-04 ! myeloid leukocyte differentiation GO:0002573 46 25 3,000 4,311E-06 8,101E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 4,658E-06 8,129E-04 ! ER overload response GO:0006983 13 8 2,000 4,658E-06 7,587E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 4,658E-06 7,112E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 4,658E-06 6,694E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 5,077E-06 6,891E-04 ! response to endoplasmic reticulum stress GO:0034976 46 26 3,000 5,077E-06 6,528E-04 ! leukocyte differentiation GO:0002521 232 98 5,000 5,08E-06 6,205E-04 ! establishment of organelle localization GO:0051656 122 59 4,000 6,514E-06 7,578E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 6,906E-06 7,668E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 6,965E-06 7,398E-04 ! macrophage differentiation GO:0030225 15 9 2,000 6,965E-06 7,089E-04 ! ER-nuclear signaling pathway GO:0006984 52 29 3,000 7,983E-06 7,801E-04 ! response to peptide hormone stimulus GO:0043434 129 64 4,000 9,745E-06 9,157E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 9,917E-06 8,973E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 9,917E-06 8,653E-04 ! regulation of B cell proliferation GO:0030888 22 12 2,000 1,806E-05 1,522E-03 ! regulation of cell projection assembly GO:0060491 33 12 2,000 1,806E-05 1,471E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 1,806E-05 1,424E-03 GO:0042130|negative regulation of T cell proliferation, ! organelle localization GO:0051640 155 74 4,000 1,987E-05 1,517E-03 ! mesenchymal cell development GO:0014031 94 41 3,000 3,266E-05 2,418E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of intracellular protein transport GO:0033157 86 42 3,000 3,598E-05 2,585E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 4,539E-05 3,168E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 4,74E-05 3,217E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 5,174E-05 3,416E-03 ! regulation of gene-specific transcription GO:0032583 102 46 3,000 5,174E-05 3,326E-03 ! filopodium assembly GO:0046847 42 17 2,000 5,493E-05 3,441E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 5,993E-05 3,66E-03 ! microspike assembly GO:0030035 46 18 2,000 6,571E-05 3,915E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 6,649E-05 3,867E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 7,693E-05 4,371E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 9,063E-05 5,032E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 9,12E-05 4,951E-03 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 9,12E-05 4,844E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 9,12E-05 4,741E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 1,125E-04 5,727E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 3,000 1,206E-04 6,013E-03 ! regulation of intracellular transport GO:0032386 108 57 3,000 1,206E-04 5,892E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 1,224E-04 5,863E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,224E-04 5,751E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 1,291E-04 5,95E-03 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 1,598E-04 7,231E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 1,81E-04 8,042E-03 ! interaction with host GO:0051701 66 25 2,000 1,81E-04 7,898E-03 ! protein tetramerization GO:0051262 57 25 2,000 1,81E-04 7,76E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 1,894E-04 7,977E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,922E-04 7,958E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 1,922E-04 7,825E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 1,922E-04 7,697E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 1,922E-04 7,573E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 1,922E-04 7,452E-03 ! valine metabolic process GO:0006573 12 5 1,000 1,922E-04 7,336E-03 ! virus-infected cell apoptosis GO:0006926 7 5 1,000 1,922E-04 7,223E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 1,922E-04 7,114E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 1,922E-04 7,007E-03 ! stem cell division GO:0017145 11 5 1,000 1,922E-04 6,904E-03 GO:0048103|somatic stem cell division, ! positive regulation of cell motion GO:0051272 157 65 3,000 2,011E-04 7,121E-03 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 2,04E-04 7,119E-03 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of cell development GO:0010721 83 26 2,000 2,04E-04 7,019E-03 GO:0050768|negative regulation of neurogenesis, ! negative regulation of cell growth GO:0030308 142 67 3,000 2,261E-04 7,673E-03 ! myeloid cell differentiation GO:0030099 126 67 3,000 2,261E-04 7,568E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 2,288E-04 7,552E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 2,288E-04 7,451E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 2,533E-04 8,142E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 2,533E-04 8,037E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 2,554E-04 7,998E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 2,677E-04 8,28E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 2,874E-04 8,778E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 2,874E-04 8,669E-03 GO:0045686|negative regulation of glial cell differentiation, ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 2,874E-04 8,563E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 2,874E-04 8,46E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 3,144E-04 9,145E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 3,144E-04 9,038E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 2,000 3,144E-04 8,933E-03 ! regulation of caspase activity GO:0043281 136 74 3,000 3,314E-04 9,307E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 3,314E-04 9,201E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 3,47E-04 9,525E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 3,47E-04 9,419E-03 ! regulation of transcription factor activity GO:0051090 137 75 3,000 3,489E-04 9,367E-03 GO:0090046|regulation of transcription regulator activity, ! spindle organization GO:0007051 50 32 2,000 3,817E-04 0,0101351 ! positive regulation of catabolic process GO:0009896 72 32 2,000 3,817E-04 0,01002612 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 3,858E-04 0,01002716 ! regulation of helicase activity GO:0051095 16 7 1,000 4,012E-04 0,01031822 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 4,012E-04 0,01021074 ! mRNA stabilization GO:0048255 18 7 1,000 4,012E-04 0,01010548 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 4,012E-04 0,01000236 ! male sex determination GO:0030238 15 7 1,000 4,012E-04 9,901E-03 ! monocyte differentiation GO:0030224 16 7 1,000 4,012E-04 9,802E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 4,012E-04 9,705E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 4,012E-04 9,61E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 4,012E-04 9,517E-03 ! protein oligomerization GO:0051259 149 79 3,000 4,254E-04 9,994E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 4,575E-04 0,01064451 ! regulation of peptidase activity GO:0052547 150 82 3,000 4,902E-04 0,0112979 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 5,334E-04 0,01217927 ! succinate metabolic process GO:0006105 17 8 1,000 5,334E-04 0,0120665 ! T-helper 1 type immune response GO:0042088 12 8 1,000 5,334E-04 0,0119558 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 5,334E-04 0,01184711 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 5,334E-04 0,01174038 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 5,334E-04 0,01163555 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 5,334E-04 0,01153258 ! regulation of vascular permeability GO:0043114 12 8 1,000 5,334E-04 0,01143142 ! response to tumor cell GO:0002347 16 8 1,000 5,334E-04 0,01133201 ! regulation of respiratory burst GO:0060263 12 8 1,000 5,334E-04 0,01123432 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 5,334E-04 0,0111383 ! negative regulation of DNA binding GO:0043392 67 36 2,000 5,424E-04 0,01122871 ! negative regulation of growth GO:0045926 168 85 3,000 5,617E-04 0,01153136 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 2,000 5,883E-04 0,01197703 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 5,883E-04 0,01187804 ! negative regulation of cell activation GO:0050866 69 37 2,000 5,883E-04 0,01178068 ! regulation of protein transport GO:0051223 165 87 3,000 6,133E-04 0,01218098 GO:0070201|regulation of establishment of protein localization, ! meiosis I GO:0007127 74 38 2,000 6,367E-04 0,01254354 ! regulation of DNA binding GO:0051101 167 89 3,000 6,681E-04 0,0130583 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 6,839E-04 0,01325919 ! induction of positive chemotaxis GO:0050930 17 9 1,000 6,839E-04 0,01315479 ! regulation of glycolysis GO:0006110 20 9 1,000 6,839E-04 0,01305202 ! microtubule bundle formation GO:0001578 22 9 1,000 6,839E-04 0,01295084 ! negative regulation of binding GO:0051100 71 39 2,000 6,875E-04 0,01291982 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 7,968E-04 0,01485868 ! regulation of developmental growth GO:0048638 16 10 1,000 8,523E-04 0,01577474 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 8,523E-04 0,01565613 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 8,523E-04 0,0155393 ! lung alveolus development GO:0048286 26 10 1,000 8,523E-04 0,01542419 ! phosphagen metabolic process GO:0006599 17 10 1,000 8,523E-04 0,01531078 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 22 10 1,000 8,523E-04 0,01519902 ! regulation of bone resorption GO:0045124 25 10 1,000 8,523E-04 0,01508888 ! protein heterooligomerization GO:0051291 17 10 1,000 8,523E-04 0,01498033 ! regulation of gliogenesis GO:0014013 23 10 1,000 8,523E-04 0,01487333 GO:0045685|regulation of glial cell differentiation, ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 8,523E-04 0,01476784 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 8,523E-04 0,01466384 ! T cell differentiation GO:0030217 93 42 2,000 8,553E-04 0,01461158 ! regulation of T cell differentiation GO:0045580 78 42 2,000 8,553E-04 0,01451011 ! regulation of T cell proliferation GO:0042129 80 43 2,000 9,165E-04 0,01544085 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 9,226E-04 0,01543816 ! regulation of protein localization GO:0032880 188 97 3,000 9,226E-04 0,01533314 ! blood vessel remodeling GO:0001974 30 11 1,000 1,039E-03 0,01714603 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,039E-03 0,01703096 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,039E-03 0,01691742 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,039E-03 0,01680538 ! regulation of intracellular pH GO:0051453 21 11 1,000 1,039E-03 0,01669482 ! nitric oxide metabolic process GO:0046209 17 11 1,000 1,039E-03 0,0165857 GO:0006809|nitric oxide biosynthetic process, ! neuroblast proliferation GO:0007405 25 11 1,000 1,039E-03 0,016478 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,039E-03 0,01637169 ! regulation of embryonic development GO:0045995 35 11 1,000 1,039E-03 0,01626675 ! positive regulation of protein transport GO:0051222 80 46 2,000 1,116E-03 0,01737219 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,243E-03 0,01921715 ! virus-host interaction GO:0019048 30 12 1,000 1,243E-03 0,01909628 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 1,243E-03 0,01897693 GO:0050927|positive regulation of positive chemotaxis, ! hippocampus development GO:0021766 29 12 1,000 1,243E-03 0,01885906 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,243E-03 0,01874265 ! focal adhesion formation GO:0048041 37 12 1,000 1,243E-03 0,01862766 ! entry into host cell GO:0030260 34 12 1,000 1,243E-03 0,01851408 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 1,243E-03 0,01840187 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,243E-03 0,01829102 ! regulation of leukocyte migration GO:0002685 29 12 1,000 1,243E-03 0,01818149 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 1,243E-03 0,01807327 ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 1,342E-03 0,01939884 ! activation of caspase activity GO:0006919 95 50 2,000 1,423E-03 0,02044961 ! endocrine pancreas development GO:0031018 25 13 1,000 1,465E-03 0,02092379 ! response to X-ray GO:0010165 28 13 1,000 1,465E-03 0,02080214 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,465E-03 0,0206819 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 1,465E-03 0,02056304 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of mRNA stability GO:0043488 32 13 1,000 1,465E-03 0,02044554 ! regulation of cell projection organization GO:0031344 135 51 2,000 1,507E-03 0,02091943 ! negative regulation of immune system process GO:0002683 101 51 2,000 1,507E-03 0,02080124 ! positive regulation of growth GO:0045927 96 53 2,000 1,684E-03 0,02311829 ! regulation of cellular pH GO:0030641 27 14 1,000 1,704E-03 0,02325255 ! response to gamma radiation GO:0010332 30 14 1,000 1,704E-03 0,02312337 ! regulation of RNA stability GO:0043487 33 14 1,000 1,704E-03 0,02299562 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,704E-03 0,02286927 ! response to UV GO:0009411 120 55 2,000 1,874E-03 0,02502123 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,96E-03 0,02602522 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 1,96E-03 0,02588455 ! regulation of mRNA processing GO:0050684 26 15 1,000 1,96E-03 0,02574538 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 1,96E-03 0,02560771 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 1,96E-03 0,0254715 ! G1/S transition checkpoint GO:0031575 37 15 1,000 1,96E-03 0,02533673 ! synaptic transmission, cholinergic GO:0007271 24 15 1,000 1,96E-03 0,02520337 ! positive regulation of caspase activity GO:0043280 108 57 2,000 2,077E-03 0,02656574 GO:0010952|positive regulation of peptidase activity, ! aging GO:0007568 112 58 2,000 2,183E-03 0,02777928 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,234E-03 0,02827406 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 2,234E-03 0,02812831 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 2,234E-03 0,02798407 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 2,234E-03 0,02784129 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 2,234E-03 0,02769996 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 2,524E-03 0,03114437 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 2,524E-03 0,03098786 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 2,524E-03 0,03083292 GO:0031114|regulation of microtubule depolymerization, ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 2,524E-03 0,03067953 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 2,524E-03 0,03052765 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 2,524E-03 0,03037727 ! viral reproductive process GO:0022415 132 62 2,000 2,642E-03 0,03163613 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 2,642E-03 0,03148181 ! regulation of protein complex assembly GO:0043254 132 63 2,000 2,765E-03 0,03278979 ! limbic system development GO:0021761 40 18 1,000 2,831E-03 0,03341712 ! cell-substrate junction assembly GO:0007044 56 18 1,000 2,831E-03 0,03325646 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 2,831E-03 0,03309733 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 2,831E-03 0,03293973 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 2,831E-03 0,03278362 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 3,155E-03 0,03636224 ! pigmentation during development GO:0048066 42 19 1,000 3,155E-03 0,03619153 ! neuromuscular junction development GO:0007528 43 19 1,000 3,155E-03 0,03602241 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 3,155E-03 0,03585486 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 3,156E-03 0,03568932 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 3,156E-03 0,03552485 ! activation of MAPK activity GO:0000187 124 67 2,000 3,293E-03 0,0369007 ! viral reproduction GO:0016032 142 68 2,000 3,434E-03 0,03830426 ! adaptive immune response GO:0002250 126 68 2,000 3,434E-03 0,03813015 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 2,000 3,434E-03 0,03795761 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 3,496E-03 0,03847104 ! protein amino acid acetylation GO:0006473 41 20 1,000 3,496E-03 0,03829853 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 3,496E-03 0,03812755 GO:0010675|regulation of cellular carbohydrate metabolic process, ! pancreas development GO:0031016 40 20 1,000 3,496E-03 0,0379581 ! cellular response to unfolded protein GO:0034620 35 20 1,000 3,496E-03 0,03779014 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 3,496E-03 0,03762366 ! actin filament bundle formation GO:0051017 47 20 1,000 3,496E-03 0,03745865 ! negative regulation of translation GO:0017148 32 20 1,000 3,496E-03 0,03729507 ! lung development GO:0030324 165 69 2,000 3,578E-03 0,03800785 ! lipid phosphorylation GO:0046834 43 21 1,000 3,853E-03 0,04074591 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 3,853E-03 0,04057028 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 3,853E-03 0,04039616 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 3,853E-03 0,04022353 ! leukotriene biosynthetic process GO:0019370 42 21 1,000 3,853E-03 0,04005236 GO:0043450|alkene biosynthetic process, ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 3,853E-03 0,03988265 ! cell cycle checkpoint GO:0000075 145 71 2,000 3,878E-03 0,03997937 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 3,878E-03 0,03981139 ! respiratory tube development GO:0030323 171 72 2,000 4,034E-03 0,0412359 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 4,226E-03 0,04301513 ! inactivation of MAPK activity GO:0000188 45 22 1,000 4,226E-03 0,04283665 ! cellular response to starvation GO:0009267 37 22 1,000 4,226E-03 0,04265964 ! apoptotic nuclear changes GO:0030262 34 22 1,000 4,226E-03 0,04248408 ! cell aging GO:0007569 48 22 1,000 4,226E-03 0,04230997 ! positive regulation of locomotion GO:0040017 44 22 1,000 4,226E-03 0,04213727 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! peptidyl-serine modification GO:0018209 50 22 1,000 4,226E-03 0,04196598 ! positive regulation of B cell activation GO:0050871 42 22 1,000 4,226E-03 0,04179608 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 4,226E-03 0,04162755 ! respiratory system development GO:0060541 175 74 2,000 4,357E-03 0,04274492 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 4,524E-03 0,0442058 ! positive regulation of DNA replication GO:0045740 44 23 1,000 4,615E-03 0,04491709 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 4,615E-03 0,04473885 ! regulation of chemotaxis GO:0050920 45 23 1,000 4,615E-03 0,04456201 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 4,615E-03 0,04438657 GO:0010810|regulation of cell-substrate adhesion, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 4,615E-03 0,04421251 ! lymphocyte differentiation GO:0030098 193 76 2,000 4,695E-03 0,04479988 ! regulation of catabolic process GO:0009894 173 77 2,000 4,869E-03 0,04628602 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 5,02E-03 0,0475334 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 5,02E-03 0,04734987 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 5,02E-03 0,04716776 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 5,02E-03 0,04698704 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 5,02E-03 0,0468077 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 5,02E-03 0,04662972 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 5,02E-03 0,0464531 ! sex determination GO:0007530 48 24 1,000 5,02E-03 0,0462778 ! leukotriene metabolic process GO:0006691 47 24 1,000 5,02E-03 0,04610383 ! pallium development GO:0021543 56 24 1,000 5,02E-03 0,04593115 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 5,02E-03 0,04575977 ! negative regulation of organelle organization GO:0010639 181 80 2,000 5,417E-03 0,04919263 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 5,441E-03 0,049228 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 5,441E-03 0,04904634 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 5,441E-03 0,04886603 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 5,441E-03 0,04868703 ! vasculogenesis GO:0001570 49 25 1,000 5,441E-03 0,04850934 ! negative regulation of DNA replication GO:0008156 45 25 1,000 5,441E-03 0,04833294 ! regulation of behavior GO:0050795 48 25 1,000 5,441E-03 0,04815782 ! cellular alkene metabolic process GO:0043449 48 25 1,000 5,441E-03 0,04798397 ! meiosis GO:0007126 143 81 2,000 5,607E-03 0,04927269 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 2,000 5,607E-03 0,04909609 ! protein import into nucleus GO:0006606 174 82 2,000 5,801E-03 0,05061608 ! meiotic cell cycle GO:0051321 144 82 2,000 5,801E-03 0,05043595 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 5,877E-03 0,05091368 ! myelination GO:0042552 50 26 1,000 5,877E-03 0,05073378 ! initiation of viral infection GO:0019059 60 26 1,000 5,877E-03 0,05055514 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 5,877E-03 0,05037775 ! positive regulation of nuclear division GO:0051785 41 26 1,000 5,877E-03 0,0502016 GO:0045840|positive regulation of mitosis, ! response to oxygen levels GO:0070482 183 83 2,000 6E-03 0,05106951 ! nuclear import GO:0051170 177 83 2,000 6E-03 0,05089218 ! T cell activation GO:0042110 189 84 2,000 6,202E-03 0,0524263 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 6,329E-03 0,05331574 ! mitochondrial membrane organization GO:0007006 60 27 1,000 6,329E-03 0,05313252 ! response to starvation GO:0042594 47 27 1,000 6,329E-03 0,05295056 ! response to toxin GO:0009636 49 27 1,000 6,329E-03 0,05276984 ! regulation of chromosome organization GO:0033044 49 27 1,000 6,329E-03 0,05259035 ! cellular response to nutrient levels GO:0031669 45 27 1,000 6,329E-03 0,05241208 ! protein amino acid acylation GO:0043543 59 28 1,000 6,796E-03 0,05609096 ! dendrite development GO:0016358 67 28 1,000 6,796E-03 0,0559021 ! base-excision repair GO:0006284 41 28 1,000 6,796E-03 0,05571451 ! mitochondrion organization GO:0007005 159 87 2,000 6,833E-03 0,0558304 ! protein localization in nucleus GO:0034504 192 89 2,000 7,274E-03 0,05923755 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 7,279E-03 0,05907439 ! somitogenesis GO:0001756 52 29 1,000 7,279E-03 0,05887878 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 7,279E-03 0,05868446 ! response to unfolded protein GO:0006986 139 90 2,000 7,501E-03 0,06028081 ! regulation of cell cycle process GO:0010564 161 90 2,000 7,501E-03 0,06008316 ! icosanoid biosynthetic process GO:0046456 60 30 1,000 7,776E-03 0,06208045 ! complement activation, classical pathway GO:0006958 51 30 1,000 7,776E-03 0,06187824 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 7,776E-03 0,06167733 ! tissue homeostasis GO:0001894 50 30 1,000 7,776E-03 0,06147773 GO:0048871|multicellular organismal homeostasis, ! regulation of cell adhesion GO:0030155 241 92 2,000 7,967E-03 0,0627871 ! cell junction assembly GO:0034329 85 31 1,000 8,288E-03 0,06510696 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 8,288E-03 0,06489828 ! ensheathment of neurons GO:0007272 64 31 1,000 8,288E-03 0,06469094 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 1,000 8,288E-03 0,06448492 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 8,815E-03 0,06836821 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 1,000 8,815E-03 0,06815186 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 8,815E-03 0,06793687 ! peripheral nervous system development GO:0007422 68 32 1,000 8,815E-03 0,06772323 ! response to protein stimulus GO:0051789 158 96 2,000 8,95E-03 0,06853964 ! regulation of T cell activation GO:0050863 175 96 2,000 8,95E-03 0,06832545 ! regulation of pH GO:0006885 56 33 1,000 9,357E-03 0,07121323 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 9,357E-03 0,07099207 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 1,000 9,357E-03 0,07077228 ! response to ionizing radiation GO:0010212 74 33 1,000 9,357E-03 0,07055385 ! negative regulation of protein transport GO:0051224 74 33 1,000 9,357E-03 0,07033676 ! negative regulation of MAP kinase activity GO:0043407 78 34 1,000 9,913E-03 0,07428929 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01000004 0,0747098 GO:0060538|skeletal muscle organ development, ! DNA damage checkpoint GO:0000077 78 35 1,000 0,01048393 0,07808608 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01048393 0,07784874 ! telencephalon development GO:0021537 81 35 1,000 0,01048393 0,07761283 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01106873 0,08169455 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,01106873 0,08144848 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01106873 0,08120389 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01166761 0,08534121 ! xenobiotic metabolic process GO:0006805 55 37 1,000 0,01166761 0,08508646 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01166761 0,08483322 ! cell junction organization GO:0034330 96 37 1,000 0,01166761 0,08458149 ! tissue remodeling GO:0048771 78 37 1,000 0,01166761 0,08433125 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,01166761 0,08408249 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,01228044 0,08823854 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,01228044 0,08797978 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,01228044 0,08772253 ! regulation of protein stability GO:0031647 77 38 1,000 0,01228044 0,08746678 ! glycogen metabolic process GO:0005977 63 38 1,000 0,01228044 0,08721252 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,01290708 0,0913971 ! carbohydrate homeostasis GO:0033500 59 39 1,000 0,01290708 0,09113294 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01290708 0,09087031 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 0,01290708 0,09060919 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 1,000 0,01354741 0,09483186 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 1,000 0,01354741 0,09456091 ! nucleus organization GO:0006997 73 40 1,000 0,01354741 0,09429151 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,01354741 0,09402364 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,01420129 0,09828257 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01420129 0,09800493 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,01420129 0,09772886 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,01486859 0,1020336 ! cytokinesis GO:0000910 84 42 1,000 0,01486859 0,10174779 ! response to xenobiotic stimulus GO:0009410 63 42 1,000 0,01486859 0,10146358 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01554918 0,10581238 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,01554918 0,10551846 ! glucose transport GO:0015758 66 43 1,000 0,01554918 0,10522617 ! segmentation GO:0035282 78 43 1,000 0,01554918 0,10493549 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,01624293 0,10931539 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,01624293 0,10901507 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,01624293 0,1087164 ! hexose transport GO:0008645 68 44 1,000 0,01624293 0,10841936 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 0,01624293 0,10812394 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01694972 0,1125222 ! B cell differentiation GO:0030183 124 45 1,000 0,01694972 0,11221726 ! negative regulation of cell migration GO:0030336 122 46 1,000 0,01766942 0,1166659 ! pigmentation GO:0043473 103 46 1,000 0,01766942 0,11635144 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,01914702 0,12574242 ! mitochondrial transport GO:0006839 94 48 1,000 0,01914702 0,12540531 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,01914702 0,12507 ! cellular component disassembly GO:0022411 89 48 1,000 0,01914702 0,12473648 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,01914702 0,12440473 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,01914702 0,12407475 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,01914702 0,12374651 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,01914702 0,12342 ! protein homooligomerization GO:0051260 84 49 1,000 0,01990469 0,12796618 ! regulation of action potential GO:0001508 102 50 1,000 0,02067476 0,13256806 ! endocrine system development GO:0035270 109 50 1,000 0,02067476 0,13222102 ! immunoglobulin mediated immune response GO:0016064 89 50 1,000 0,02067476 0,13187579 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,02067476 0,13153237 ! viral infectious cycle GO:0019058 104 51 1,000 0,02145711 0,13615512 ! response to temperature stimulus GO:0009266 84 51 1,000 0,02145711 0,13580238 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02189228 0,13819855 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02189228 0,13784237 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02189228 0,13748802 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02189228 0,13713548 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02189228 0,13678475 ! neuron fate determination GO:0048664 7 5 0,000 0,02189228 0,13643581 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02189228 0,13608865 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02189228 0,13574324 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02189228 0,13539959 ! polyol transport GO:0015791 12 5 0,000 0,02189228 0,13505767 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02189228 0,13471748 ! response to superoxide GO:0000303 10 5 0,000 0,02189228 0,13437899 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02189228 0,1340422 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02189228 0,1337071 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02189228 0,13337366 ! female meiosis GO:0007143 10 5 0,000 0,02189228 0,13304189 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02189228 0,13271176 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02189228 0,13238326 ! hypothalamus development GO:0021854 9 5 0,000 0,02189228 0,13205639 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02189228 0,13173113 ! cobalt ion transport GO:0006824 11 5 0,000 0,02189228 0,13140747 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02189228 0,13108539 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02189228 0,13076489 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02189228 0,13044595 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02189228 0,13012856 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02189228 0,12981271 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02189228 0,1294984 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02189228 0,1291856 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02189228 0,12887431 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02189228 0,12856452 ! transposition GO:0032196 9 5 0,000 0,02189228 0,12825621 ! negative chemotaxis GO:0050919 16 5 0,000 0,02189228 0,12794937 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02189228 0,12764401 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02189228 0,12734009 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02189228 0,12703762 ! behavioral response to pain GO:0048266 10 5 0,000 0,02189228 0,12673658 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02189228 0,12643697 ! Notch receptor processing GO:0007220 11 5 0,000 0,02189228 0,12613877 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02189228 0,12584197 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02189228 0,12554657 ! micturition GO:0060073 9 5 0,000 0,02189228 0,12525255 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02189228 0,1249599 ! copulation GO:0007620 9 5 0,000 0,02189228 0,12466862 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02189228 0,12437869 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02189228 0,12409011 ! bioluminescence GO:0008218 9 5 0,000 0,02189228 0,12380287 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02189228 0,12351695 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02189228 0,12323235 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02189228 0,12294905 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02189228 0,12266706 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02189228 0,12238636 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02189228 0,12210694 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02189228 0,12182879 ! grooming behavior GO:0007625 6 5 0,000 0,02189228 0,12155191 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02189228 0,12127628 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02189228 0,1210019 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02189228 0,12072876 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02189228 0,12045684 ! response to protozoan GO:0001562 13 5 0,000 0,02189228 0,12018615 ! lymph vessel development GO:0001945 10 5 0,000 0,02189228 0,11991668 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02189228 0,11964841 ! endochondral ossification GO:0001958 17 5 0,000 0,02189228 0,11938134 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02189228 0,11911545 ! single strand break repair GO:0000012 8 5 0,000 0,02189228 0,11885075 ! parathyroid gland development GO:0060017 14 5 0,000 0,02189228 0,11858723 ! anagen GO:0042640 7 5 0,000 0,02189228 0,11832486 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02189228 0,11806366 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02189228 0,11780361 ! cytokine secretion GO:0050663 15 5 0,000 0,02189228 0,1175447 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02189228 0,11728693 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02189228 0,11703028 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02189228 0,11677476 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02189228 0,11652035 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02189228 0,11626704 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02189228 0,11601483 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02189228 0,11576372 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02189228 0,11551369 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02189228 0,11526474 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02189228 0,11501686 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02189228 0,11477004 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02189228 0,11452428 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02189228 0,11427957 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02189228 0,1140359 ! microvillus organization GO:0032528 8 5 0,000 0,02189228 0,11379327 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02189228 0,11355167 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02189228 0,1133111 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02189228 0,11307154 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02189228 0,11283299 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02189228 0,11259545 ! polyol catabolic process GO:0046174 9 5 0,000 0,02189228 0,1123589 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02189228 0,11212335 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02189228 0,11188878 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02189228 0,1116552 ! muscle cell migration GO:0014812 8 5 0,000 0,02189228 0,11142258 ! mitochondrial fission GO:0000266 8 5 0,000 0,02189228 0,11119093 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02189228 0,11096025 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02189228 0,11073051 ! mRNA transcription GO:0009299 10 5 0,000 0,02189228 0,11050173 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02189228 0,11027389 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02189228 0,11004699 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02189228 0,10982102 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02189228 0,10959598 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02189228 0,10937186 ! monocyte activation GO:0042117 10 5 0,000 0,02189228 0,10914865 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02189228 0,10892635 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02189228 0,10870496 ! response to food GO:0032094 6 5 0,000 0,02189228 0,10848446 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02189228 0,10826486 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02189228 0,10804614 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02189228 0,1078283 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02189228 0,10761135 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02189228 0,10739526 ! forebrain neuron development GO:0021884 13 5 0,000 0,02189228 0,10718004 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02189228 0,10696568 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02189228 0,10675217 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02189228 0,10653952 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02189228 0,10632771 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02189228 0,10611674 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02189228 0,10590661 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02189228 0,10569731 ! lipid glycosylation GO:0030259 7 5 0,000 0,02189228 0,10548883 ! nucleobase transport GO:0015851 6 5 0,000 0,02189228 0,10528118 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02189228 0,10507434 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02189228 0,10486831 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02189228 0,10466309 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02189228 0,10445867 ! basic amino acid transport GO:0015802 12 5 0,000 0,02189228 0,10425505 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02189228 0,10405221 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02189228 0,10385017 ! actin nucleation GO:0045010 11 5 0,000 0,02189228 0,10364891 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02189228 0,10344843 ! depurination GO:0045007 5 5 0,000 0,02189228 0,10324872 ! depyrimidination GO:0045008 10 5 0,000 0,02189228 0,10304979 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02189228 0,10285161 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02189228 0,1026542 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02189228 0,10245754 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02189228 0,10226164 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02189228 0,10206649 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02189228 0,10187207 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02189228 0,1016784 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02189228 0,10148546 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02189228 0,10129325 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02189228 0,10110177 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02189228 0,10091102 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02189228 0,10072098 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02189228 0,10053165 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02189228 0,10034304 ! response to arsenic GO:0046685 11 5 0,000 0,02189228 0,10015513 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02189228 0,09996792 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02189228 0,09978142 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02189228 0,0995956 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02189228 0,09941048 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02189228 0,09922605 ! response to mercury ion GO:0046689 8 5 0,000 0,02189228 0,09904229 ! response to cadmium ion GO:0046686 7 5 0,000 0,02189228 0,09885922 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02189228 0,09867682 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02189228 0,0984951 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02189228 0,09831404 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02189228 0,09813365 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02189228 0,09795392 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02189228 0,09777484 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02189228 0,09759642 ! decidualization GO:0046697 11 5 0,000 0,02189228 0,09741865 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02189228 0,09724152 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02189228 0,09706504 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02189228 0,0968892 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02189228 0,09671399 ! embryonic cleavage GO:0040016 6 5 0,000 0,02189228 0,09653942 ! peroxisome fission GO:0016559 5 5 0,000 0,02189228 0,09636547 ! histone demethylation GO:0016577 13 5 0,000 0,02189228 0,09619216 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02189228 0,09601946 ! mitotic recombination GO:0006312 9 5 0,000 0,02189228 0,09584738 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02189228 0,09567592 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02189228 0,09550507 ! metaphase plate congression GO:0051310 7 5 0,000 0,02189228 0,09533483 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02189228 0,09516519 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02189228 0,09499616 ! enteric nervous system development GO:0048484 8 5 0,000 0,02189228 0,09482773 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02189228 0,09465989 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02189228 0,09449265 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02189228 0,09432599 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02189228 0,09415993 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02189228 0,09399444 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02189228 0,09382954 ! B cell homeostasis GO:0001782 13 5 0,000 0,02189228 0,09366522 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02189228 0,09350147 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02189228 0,09333829 ! metaphase GO:0051323 11 5 0,000 0,02189228 0,09317568 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02189228 0,09301363 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02189228 0,09285215 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02189228 0,09269123 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02189228 0,09253086 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02189228 0,09237105 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02189228 0,09221179 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02189228 0,09205308 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02189228 0,09189491 ! response to redox state GO:0051775 6 5 0,000 0,02189228 0,09173729 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02189228 0,0915802 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02189228 0,09142366 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02189228 0,09126764 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02189228 0,09111216 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02189228 0,09095721 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02189228 0,09080278 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02189228 0,09064888 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02189228 0,0904955 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02189228 0,09034263 ! striatum development GO:0021756 14 5 0,000 0,02189228 0,09019028 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02189228 0,09003845 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02189228 0,08988712 ! glial cell migration GO:0008347 10 5 0,000 0,02189228 0,08973631 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02189228 0,08958599 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02189228 0,08943618 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02189228 0,08928688 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02189228 0,08913806 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02189228 0,08898975 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02189228 0,08884192 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02189228 0,08869459 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02189228 0,08854775 ! neuroprotection GO:0043526 8 5 0,000 0,02189228 0,08840139 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02189228 0,08825551 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02189228 0,08811011 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02189228 0,08796519 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02189228 0,08782075 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02189228 0,08767678 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02189228 0,08753329 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02189228 0,08739026 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02189228 0,0872477 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02189228 0,0871056 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,02189228 0,08696397 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02189228 0,08682279 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02189228 0,08668207 ! spindle assembly GO:0051225 6 5 0,000 0,02189228 0,08654181 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02189228 0,086402 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02189228 0,08626264 ! protein palmitoylation GO:0018345 12 5 0,000 0,02189228 0,08612373 ! drug metabolic process GO:0017144 7 5 0,000 0,02189228 0,08598527 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02189228 0,08584725 ! organ regeneration GO:0031100 7 5 0,000 0,02189228 0,08570968 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02189228 0,08557254 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02189228 0,08543584 ! positive regulation of binding GO:0051099 88 52 1,000 0,02225163 0,08669972 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,02225163 0,08656166 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,02225163 0,08642404 ! histone modification GO:0016570 104 52 1,000 0,02225163 0,08628686 ! amino acid activation GO:0043038 98 52 1,000 0,02225163 0,08615011 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,02305818 0,08913155 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,02305818 0,08899074 ! synapse organization GO:0050808 102 53 1,000 0,02305818 0,08885038 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,02387666 0,09185934 ! regulation of translational initiation GO:0006446 87 54 1,000 0,02387666 0,09171491 ! covalent chromatin modification GO:0016569 115 54 1,000 0,02387666 0,09157093 ! regulation of cell shape GO:0008360 142 54 1,000 0,02387666 0,0914274 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,02470694 0,09445861 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,02470694 0,09431102 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,0255489 0,09737279 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,0255489 0,09722112 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,0255489 0,09706992 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02621325 0,09943939 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02621325 0,09928522 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02621325 0,09913153 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02621325 0,09897831 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02621325 0,09882556 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02621325 0,09867329 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02621325 0,09852149 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02621325 0,09837015 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02621325 0,09821927 ! response to oxygen radical GO:0000305 11 6 0,000 0,02621325 0,09806886 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02621325 0,09791891 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02621325 0,09776941 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02621325 0,09762037 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02621325 0,09747179 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02621325 0,09732366 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02621325 0,09717597 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02621325 0,09702874 ! forebrain regionalization GO:0021871 9 6 0,000 0,02621325 0,09688194 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02621325 0,0967356 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02621325 0,09658969 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02621325 0,09644422 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02621325 0,0962992 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02621325 0,0961546 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02621325 0,09601044 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02621325 0,09586671 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02621325 0,09572342 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02621325 0,09558055 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02621325 0,0954381 ! malate metabolic process GO:0006108 13 6 0,000 0,02621325 0,09529608 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02621325 0,09515448 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02621325 0,0950133 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02621325 0,09487254 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02621325 0,0947322 ! protein refolding GO:0042026 15 6 0,000 0,02621325 0,09459227 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02621325 0,09445275 ! opsonization GO:0008228 8 6 0,000 0,02621325 0,09431365 ! mating behavior GO:0007617 7 6 0,000 0,02621325 0,09417495 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02621325 0,09403666 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02621325 0,09389878 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02621325 0,0937613 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02621325 0,09362422 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02621325 0,09348754 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02621325 0,09335126 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02621325 0,09321538 ! toxin metabolic process GO:0009404 11 6 0,000 0,02621325 0,09307989 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02621325 0,0929448 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02621325 0,09281009 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02621325 0,09267578 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02621325 0,09254186 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02621325 0,09240832 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02621325 0,09227517 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02621325 0,0921424 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02621325 0,09201001 ! thymic T cell selection GO:0045061 16 6 0,000 0,02621325 0,091878 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02621325 0,09174637 ! protein lipoylation GO:0009249 10 6 0,000 0,02621325 0,09161512 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02621325 0,09148424 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02621325 0,09135373 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02621325 0,0912236 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02621325 0,09109383 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02621325 0,09096444 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02621325 0,09083541 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02621325 0,09070675 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02621325 0,09057845 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02621325 0,09045052 ! hyperosmotic response GO:0006972 10 6 0,000 0,02621325 0,09032294 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02621325 0,09019573 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02621325 0,09006887 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02621325 0,08994237 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02621325 0,08981622 ! urea metabolic process GO:0019627 7 6 0,000 0,02621325 0,08969043 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02621325 0,08956499 ! neutrophil activation GO:0042119 7 6 0,000 0,02621325 0,0894399 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02621325 0,08931515 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02621325 0,08919076 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02621325 0,08906671 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02621325 0,08894301 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02621325 0,08881965 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02621325 0,08869663 ! neuron apoptosis GO:0051402 15 6 0,000 0,02621325 0,08857395 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02621325 0,08845161 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02621325 0,08832961 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02621325 0,08820794 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02621325 0,08808661 ! carnitine transport GO:0015879 10 6 0,000 0,02621325 0,08796561 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02621325 0,08784495 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02621325 0,08772461 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02621325 0,0876046 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02621325 0,08748493 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02621325 0,08736557 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02621325 0,08724655 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02621325 0,08712784 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02621325 0,08700946 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02621325 0,0868914 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02621325 0,08677367 ! neural nucleus development GO:0048857 19 6 0,000 0,02621325 0,08665625 ! response to UV-C GO:0010225 14 6 0,000 0,02621325 0,08653914 ! astrocyte development GO:0014002 16 6 0,000 0,02621325 0,08642236 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02621325 0,08630588 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02621325 0,08618972 ! interaction with symbiont GO:0051702 14 6 0,000 0,02621325 0,08607388 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02621325 0,08595834 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02621325 0,08584312 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02621325 0,0857282 ! response to copper ion GO:0046688 10 6 0,000 0,02621325 0,08561359 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02621325 0,08549929 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02621325 0,08538529 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02621325 0,08527159 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02621325 0,0851582 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02621325 0,08504511 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02621325 0,08493231 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02621325 0,08481982 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02621325 0,08470763 ! hair follicle maturation GO:0048820 8 6 0,000 0,02621325 0,08459573 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02621325 0,08448412 ! Schwann cell development GO:0014044 15 6 0,000 0,02621325 0,08437281 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02621325 0,0842618 ! response to pheromone GO:0019236 6 6 0,000 0,02621325 0,08415107 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02621325 0,08404064 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02621325 0,08393049 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02621325 0,08382064 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02621325 0,08371107 ! subpallium development GO:0021544 15 6 0,000 0,02621325 0,08360178 ! neural tube patterning GO:0021532 8 6 0,000 0,02621325 0,08349278 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02621325 0,08338407 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02621325 0,08327564 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02621325 0,08316749 ! G2 phase GO:0051319 16 6 0,000 0,02621325 0,08305962 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02621325 0,08295203 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02621325 0,08284472 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02621325 0,08273768 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02621325 0,08263092 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02621325 0,08252444 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02621325 0,08241823 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02621325 0,08231229 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02621325 0,08220663 ! receptor internalization GO:0031623 11 6 0,000 0,02621325 0,08210124 ! plasminogen activation GO:0031639 9 6 0,000 0,02621325 0,08199611 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02621325 0,08189126 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02621325 0,08178667 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02621325 0,08168235 ! protein deubiquitination GO:0016579 16 6 0,000 0,02621325 0,0815783 ! protein destabilization GO:0031648 9 6 0,000 0,02621325 0,08147451 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02621325 0,08137099 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02621325 0,08126772 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02621325 0,08116472 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02621325 0,08106198 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02621325 0,0809595 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02621325 0,08085728 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02621325 0,08075532 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02621325 0,08065361 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02621325 0,08055216 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02621325 0,08045096 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02621325 0,08035002 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02621325 0,08024933 ! neural plate development GO:0001840 9 6 0,000 0,02621325 0,08014889 ! catecholamine transport GO:0051937 9 6 0,000 0,02621325 0,08004871 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02621325 0,07994877 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02621325 0,07984908 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02621325 0,07974965 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02621325 0,07965045 ! maternal placenta development GO:0001893 12 6 0,000 0,02621325 0,07955151 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02621325 0,07945281 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02621325 0,07935436 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02621325 0,07925615 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02621325 0,07915818 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02621325 0,07906045 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02621325 0,07896297 GO:0055081|anion homeostasis, ! regulation of bone remodeling GO:0046850 143 57 1,000 0,02640242 0,07943488 ! muscle fiber development GO:0048747 131 57 1,000 0,02640242 0,07933717 ! heart morphogenesis GO:0003007 105 57 1,000 0,02640242 0,0792397 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,02640242 0,07914248 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,02726739 0,0816351 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,02726739 0,08153518 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,02726739 0,08143551 ! lipid modification GO:0030258 112 60 1,000 0,02903121 0,08659738 ! DNA catabolic process GO:0006308 94 60 1,000 0,02903121 0,08649177 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,02992983 0,08906038 ! tRNA transcription GO:0009304 17 7 0,000 0,03051525 0,09069192 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03051525 0,09058172 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03051525 0,09047179 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03051525 0,09036213 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03051525 0,09025273 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03051525 0,0901436 ! sleep GO:0030431 16 7 0,000 0,03051525 0,09003473 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03051525 0,08992612 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03051525 0,08981778 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03051525 0,08970969 ! prostate gland development GO:0030850 14 7 0,000 0,03051525 0,08960187 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03051525 0,0894943 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03051525 0,089387 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03051525 0,08927995 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03051525 0,08917315 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03051525 0,08906661 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03051525 0,08896033 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03051525 0,0888543 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03051525 0,08874852 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03051525 0,08864299 ! glycolipid transport GO:0046836 11 7 0,000 0,03051525 0,08853771 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03051525 0,08843269 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03051525 0,08832791 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03051525 0,08822338 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03051525 0,0881191 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03051525 0,08801506 ! pericardium development GO:0060039 16 7 0,000 0,03051525 0,08791127 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03051525 0,08780772 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03051525 0,08770442 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03051525 0,08760136 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03051525 0,08749854 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03051525 0,08739596 ! lipoprotein transport GO:0042953 14 7 0,000 0,03051525 0,08729362 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03051525 0,08719153 ! rhythmic behavior GO:0007622 17 7 0,000 0,03051525 0,08708967 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03051525 0,08698804 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03051525 0,08688666 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03051525 0,08678551 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03051525 0,0866846 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03051525 0,08658392 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03051525 0,08648347 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03051525 0,08638326 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03051525 0,08628328 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03051525 0,08618353 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03051525 0,08608401 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03051525 0,08598472 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03051525 0,08588566 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03051525 0,08578683 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03051525 0,08568822 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03051525 0,08558984 ! spinal cord patterning GO:0021511 14 7 0,000 0,03051525 0,08549169 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03051525 0,08539376 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03051525 0,08529606 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03051525 0,08519858 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03051525 0,08510132 ! adrenal gland development GO:0030325 17 7 0,000 0,03051525 0,08500428 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03051525 0,08490747 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03051525 0,08481087 ! ovulation GO:0030728 10 7 0,000 0,03051525 0,08471449 ! adenohypophysis development GO:0021984 11 7 0,000 0,03051525 0,08461834 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03051525 0,0845224 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03051525 0,08442668 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03051525 0,08433117 ! microtubule nucleation GO:0007020 21 7 0,000 0,03051525 0,08423588 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03051525 0,08414081 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03051525 0,08404595 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03051525 0,0839513 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03051525 0,08385687 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03051525 0,08376265 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03051525 0,08366864 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03051525 0,08357484 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03051525 0,08348125 ! galactose metabolic process GO:0006012 13 7 0,000 0,03051525 0,08338787 ! vesicle fusion GO:0006906 20 7 0,000 0,03051525 0,0832947 ! response to dietary excess GO:0002021 8 7 0,000 0,03051525 0,08320173 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03051525 0,08310898 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03051525 0,08301643 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03051525 0,08292409 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03051525 0,08283195 ! organ growth GO:0035265 15 7 0,000 0,03051525 0,08274002 ! nucleoside transport GO:0015858 11 7 0,000 0,03051525 0,08264829 ! nucleoside salvage GO:0043174 11 7 0,000 0,03051525 0,08255676 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03051525 0,08246544 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03051525 0,08237431 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03051525 0,08228339 ! parturition GO:0007567 16 7 0,000 0,03051525 0,08219267 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03051525 0,08210215 ! rRNA modification GO:0000154 14 7 0,000 0,03051525 0,08201183 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03051525 0,08192171 ! spindle checkpoint GO:0031577 16 7 0,000 0,03051525 0,08183178 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03051525 0,08174206 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03051525 0,08165252 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03051525 0,08156319 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03051525 0,08147405 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03051525 0,0813851 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03051525 0,08129635 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03051525 0,08120779 ! fibrinolysis GO:0042730 11 7 0,000 0,03051525 0,08111943 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03051525 0,08103125 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03051525 0,08094327 ! eating behavior GO:0042755 8 7 0,000 0,03051525 0,08085548 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03051525 0,08076788 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03051525 0,08068047 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03051525 0,08059325 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03051525 0,08050621 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03051525 0,08041937 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03051525 0,08033271 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03051525 0,08024624 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03051525 0,08015995 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03051525 0,08007385 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03051525 0,07998793 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03051525 0,0799022 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03051525 0,07981665 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03051525 0,07973129 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03051525 0,07964611 ! histone ubiquitination GO:0016574 9 7 0,000 0,03051525 0,0795611 ! regulation of meiosis GO:0040020 12 7 0,000 0,03051525 0,07947628 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03051525 0,07939164 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03051525 0,07930719 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03051525 0,07922291 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03051525 0,07913881 ! transcription termination GO:0006353 14 7 0,000 0,03051525 0,07905488 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03051525 0,07897114 ! anaphase GO:0051322 18 7 0,000 0,03051525 0,07888757 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03051525 0,07880418 ! axonal fasciculation GO:0007413 19 7 0,000 0,03051525 0,07872097 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03051525 0,07863793 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03051525 0,07855506 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03051525 0,07847237 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03051525 0,07838986 ! diuresis GO:0030146 12 7 0,000 0,03051525 0,07830752 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03051525 0,07822535 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03051525 0,07814335 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03051525 0,07806152 ! antibiotic transport GO:0042891 9 7 0,000 0,03051525 0,07797987 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03051525 0,07789838 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03051525 0,07781707 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03051525 0,07773593 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03051525 0,07765495 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03051525 0,07757415 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03051525 0,07749351 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03051525 0,07741304 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03051525 0,07733273 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03051525 0,0772526 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03051525 0,07717262 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03051525 0,07709282 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03051525 0,07701318 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03051525 0,0769337 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03051525 0,07685439 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03051525 0,07677524 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03051525 0,07669625 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03051525 0,07661742 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03051525 0,07653876 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03051525 0,07646026 ! muscle adaptation GO:0043500 13 7 0,000 0,03051525 0,07638192 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03051525 0,07630374 ! retina homeostasis GO:0001895 12 7 0,000 0,03051525 0,07622572 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03051525 0,07614786 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03051525 0,07607016 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03051525 0,07599261 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03051525 0,07591523 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,03083943 0,07664368 ! regulation of mitosis GO:0007088 112 63 1,000 0,03175991 0,07885107 GO:0051783|regulation of nuclear division, ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,03363303 0,08341674 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,03479837 0,08621948 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,03479837 0,08613213 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,03479837 0,08604495 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,03479837 0,08595795 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,03479837 0,08587112 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03479837 0,08578447 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03479837 0,08569799 ! male meiosis GO:0007140 9 8 0,000 0,03479837 0,08561169 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,03479837 0,08552556 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,03479837 0,08543961 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,03479837 0,08535382 ! meiotic prophase I GO:0007128 14 8 0,000 0,03479837 0,08526821 ! response to zinc ion GO:0010043 12 8 0,000 0,03479837 0,08518277 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03479837 0,08509751 ! oligopeptide transport GO:0006857 16 8 0,000 0,03479837 0,08501241 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,03479837 0,08492748 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,03479837 0,08484272 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,03479837 0,08475813 ! signal peptide processing GO:0006465 12 8 0,000 0,03479837 0,08467371 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,03479837 0,08458946 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,03479837 0,08450538 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03479837 0,08442146 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,03479837 0,08433771 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,03479837 0,08425412 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,03479837 0,0841707 ! estrogen metabolic process GO:0008210 17 8 0,000 0,03479837 0,08408745 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,03479837 0,08400436 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,03479837 0,08392143 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03479837 0,08383867 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03479837 0,08375607 ! reflex GO:0060004 17 8 0,000 0,03479837 0,08367363 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03479837 0,08359135 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,03479837 0,08350924 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,03479837 0,08342729 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03479837 0,0833455 ! pigment granule organization GO:0048753 17 8 0,000 0,03479837 0,08326387 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,03479837 0,08318239 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,03479837 0,08310108 ! astrocyte differentiation GO:0048708 19 8 0,000 0,03479837 0,08301993 ! histidine catabolic process GO:0006548 10 8 0,000 0,03479837 0,08293893 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03479837 0,0828581 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,03479837 0,08277742 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,03479837 0,08269689 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,03479837 0,08261653 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,03479837 0,08253632 ! melanin metabolic process GO:0006582 17 8 0,000 0,03479837 0,08245626 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,03479837 0,08237636 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,03479837 0,08229662 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,03479837 0,08221703 ! macrophage activation GO:0042116 13 8 0,000 0,03479837 0,08213759 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03479837 0,08205831 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,03479837 0,08197918 ! purine salvage GO:0043101 12 8 0,000 0,03479837 0,0819002 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,03479837 0,08182137 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,03479837 0,0817427 ! osteoblast development GO:0002076 17 8 0,000 0,03479837 0,08166418 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,03479837 0,0815858 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,03479837 0,08150758 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,03479837 0,08142951 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,03479837 0,08135159 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03479837 0,08127381 ! response to UV-B GO:0010224 17 8 0,000 0,03479837 0,08119619 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,03479837 0,08111871 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03479837 0,08104138 ! intermediate filament organization GO:0045109 12 8 0,000 0,03479837 0,0809642 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,03479837 0,08088716 ! cellular extravasation GO:0045123 13 8 0,000 0,03479837 0,08081027 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,03479837 0,08073353 ! response to antibiotic GO:0046677 11 8 0,000 0,03479837 0,08065693 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,03479837 0,08058048 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,03479837 0,08050417 ! DNA topological change GO:0006265 12 8 0,000 0,03479837 0,08042801 ! response to tropane GO:0014073 15 8 0,000 0,03479837 0,08035199 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,03479837 0,08027612 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,03479837 0,08020038 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03479837 0,0801248 ! mast cell activation GO:0045576 14 8 0,000 0,03479837 0,08004935 ! multicellular organismal aging GO:0010259 20 8 0,000 0,03479837 0,07997404 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,03479837 0,07989888 ! gas homeostasis GO:0033483 14 8 0,000 0,03479837 0,07982386 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,03479837 0,07974898 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,03479837 0,07967423 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,03479837 0,07959963 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03479837 0,07952517 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03479837 0,07945085 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03479837 0,07937666 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,03479837 0,07930262 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,03479837 0,07922871 ! intracellular lipid transport GO:0032365 16 8 0,000 0,03479837 0,07915494 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03479837 0,07908131 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,03479837 0,07900781 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,03479837 0,07893445 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03479837 0,07886123 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,03479837 0,07878814 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,03479837 0,07871519 ! hormone catabolic process GO:0042447 17 8 0,000 0,03479837 0,07864238 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,03479837 0,07856969 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,03479837 0,07849714 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,03479837 0,07842473 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,03479837 0,07835245 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03479837 0,0782803 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,03479837 0,07820829 ! adult feeding behavior GO:0008343 10 8 0,000 0,03479837 0,0781364 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,03479837 0,07806465 ! ATP catabolic process GO:0006200 11 8 0,000 0,03479837 0,07799303 ! blastocyst growth GO:0001832 19 8 0,000 0,03479837 0,07792155 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03479837 0,07785019 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03479837 0,07777896 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,03479837 0,07770787 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03479837 0,0776369 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,03479837 0,07756607 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,03479837 0,07749536 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,03479837 0,07742478 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,03479837 0,07735433 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,03479837 0,07728401 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,03479837 0,07721381 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03479837 0,07714375 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,03479837 0,07707381 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,03479837 0,07700399 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03479837 0,07693431 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,03479837 0,07686474 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,03479837 0,07679531 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,03479837 0,076726 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,03479837 0,07665681 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,03479837 0,07658775 ! chromosome segregation GO:0007059 127 67 1,000 0,0355483 0,07816787 ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,0355483 0,07809757 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,03652147 0,08016348 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,03750485 0,08224807 ! activation of immune response GO:0002253 120 70 1,000 0,03849833 0,08435105 ! protein maturation by peptide bond cleavage GO:0051605 118 70 1,000 0,03849833 0,08427546 ! axon extension GO:0048675 16 9 0,000 0,03906268 0,08543431 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03906268 0,08535789 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03906268 0,08528161 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03906268 0,08520547 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03906268 0,08512946 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03906268 0,08505359 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03906268 0,08497785 ! reproductive behavior GO:0019098 22 9 0,000 0,03906268 0,08490225 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03906268 0,08482678 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03906268 0,08475144 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03906268 0,08467624 ! UTP metabolic process GO:0046051 10 9 0,000 0,03906268 0,08460118 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03906268 0,08452624 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03906268 0,08445144 ! artery development GO:0060840 25 9 0,000 0,03906268 0,08437677 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03906268 0,08430223 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03906268 0,08422783 ! equilibrioception GO:0050957 20 9 0,000 0,03906268 0,08415355 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03906268 0,08407941 ! chemosensory behavior GO:0007635 21 9 0,000 0,03906268 0,08400539 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03906268 0,08393151 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03906268 0,08385776 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03906268 0,08378413 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03906268 0,08371064 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03906268 0,08363727 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03906268 0,08356403 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03906268 0,08349092 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03906268 0,08341794 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03906268 0,08334509 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03906268 0,08327236 ! protein targeting to ER GO:0045047 25 9 0,000 0,03906268 0,08319976 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03906268 0,08312729 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03906268 0,08305494 ! T cell selection GO:0045058 27 9 0,000 0,03906268 0,08298272 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03906268 0,08291062 ! glycine catabolic process GO:0006546 15 9 0,000 0,03906268 0,08283865 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03906268 0,08276681 ! endosome organization GO:0007032 20 9 0,000 0,03906268 0,08269508 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03906268 0,08262349 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03906268 0,08255201 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03906268 0,08248066 ! mannose metabolic process GO:0006013 13 9 0,000 0,03906268 0,08240944 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03906268 0,08233833 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03906268 0,08226735 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03906268 0,08219649 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03906268 0,08212575 ! receptor clustering GO:0043113 20 9 0,000 0,03906268 0,08205514 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03906268 0,08198464 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03906268 0,08191427 ! retinol metabolic process GO:0042572 20 9 0,000 0,03906268 0,08184402 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03906268 0,08177389 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03906268 0,08170388 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03906268 0,08163398 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03906268 0,08156421 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03906268 0,08149456 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03906268 0,08142502 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03906268 0,08135561 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03906268 0,08128631 ! response to amine stimulus GO:0014075 13 9 0,000 0,03906268 0,08121713 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03906268 0,08114807 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03906268 0,08107912 ! erythrocyte development GO:0048821 17 9 0,000 0,03906268 0,08101029 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03906268 0,08094158 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03906268 0,08087299 ! renal water homeostasis GO:0003091 15 9 0,000 0,03906268 0,08080451 ! postreplication repair GO:0006301 25 9 0,000 0,03906268 0,08073615 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03906268 0,0806679 ! icosanoid secretion GO:0032309 15 9 0,000 0,03906268 0,08059977 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03906268 0,08053175 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03906268 0,08046385 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03906268 0,08039606 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03906268 0,08032839 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03906268 0,08026083 ! sterol catabolic process GO:0016127 14 9 0,000 0,03906268 0,08019338 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03906268 0,08012605 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03906268 0,08005883 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03906268 0,07999172 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03906268 0,07992473 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03906268 0,07985785 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03906268 0,07979108 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03906268 0,07972442 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03906268 0,07965787 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03906268 0,07959143 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03906268 0,07952511 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03906268 0,07945889 ! purine base metabolic process GO:0006144 25 9 0,000 0,03906268 0,07939278 ! pigment granule transport GO:0051904 17 9 0,000 0,03906268 0,07932679 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03906268 0,0792609 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03906268 0,07919513 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03906268 0,07912946 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03906268 0,0790639 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03906268 0,07899845 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03906268 0,07893311 ! mitochondrion localization GO:0051646 18 9 0,000 0,03906268 0,07886787 ! carbohydrate transport GO:0008643 114 72 1,000 0,04051516 0,0817329 ! actin filament organization GO:0007015 167 72 1,000 0,04051516 0,08166547 ! B cell activation GO:0042113 179 72 1,000 0,04051516 0,08159814 ! humoral immune response GO:0006959 115 73 1,000 0,04153831 0,08358986 ! acute inflammatory response GO:0002526 118 74 1,000 0,04257113 0,08559776 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,04257113 0,08552736 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,04330827 0,08693682 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04330827 0,08686544 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04330827 0,08679418 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04330827 0,08672304 ! associative learning GO:0008306 21 10 0,000 0,04330827 0,08665202 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,04330827 0,08658111 ! phosphate transport GO:0006817 24 10 0,000 0,04330827 0,08651031 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04330827 0,08643963 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,04330827 0,08636907 ! CTP metabolic process GO:0046036 11 10 0,000 0,04330827 0,08629862 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,04330827 0,08622829 ! GTP metabolic process GO:0046039 11 10 0,000 0,04330827 0,08615807 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04330827 0,08608797 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04330827 0,08601798 ! social behavior GO:0035176 29 10 0,000 0,04330827 0,0859481 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04330827 0,08587834 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04330827 0,08580869 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,04330827 0,08573915 ! androgen metabolic process GO:0008209 17 10 0,000 0,04330827 0,08566973 ! phospholipid efflux GO:0033700 19 10 0,000 0,04330827 0,08560041 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,04330827 0,08553121 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04330827 0,08546213 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04330827 0,08539315 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,04330827 0,08532428 ! pathogenesis GO:0009405 17 10 0,000 0,04330827 0,08525553 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04330827 0,08518688 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04330827 0,08511835 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04330827 0,08504993 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04330827 0,08498162 ! endoderm development GO:0007492 18 10 0,000 0,04330827 0,08491341 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,04330827 0,08484532 ! arginine catabolic process GO:0006527 17 10 0,000 0,04330827 0,08477733 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,04330827 0,08470946 ! proline metabolic process GO:0006560 13 10 0,000 0,04330827 0,08464169 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,04330827 0,08457403 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,04330827 0,08450648 ! V(D)J recombination GO:0033151 34 10 0,000 0,04330827 0,08443904 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04330827 0,0843717 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04330827 0,08430447 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04330827 0,08423735 ! B cell proliferation GO:0042100 19 10 0,000 0,04330827 0,08417033 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04330827 0,08410343 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04330827 0,08403663 ! multicellular organism growth GO:0035264 19 10 0,000 0,04330827 0,08396993 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,04330827 0,08390334 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04330827 0,08383685 ! ruffle organization GO:0031529 17 10 0,000 0,04330827 0,08377048 ! epithelial cell development GO:0002064 21 10 0,000 0,04330827 0,0837042 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,04330827 0,08363803 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04330827 0,08357197 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04330827 0,08350601 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04330827 0,08344015 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,04330827 0,0833744 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04330827 0,08330875 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,04330827 0,0832432 ! brain morphogenesis GO:0048854 23 10 0,000 0,04330827 0,08317776 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,04330827 0,08311242 ! segment specification GO:0007379 15 10 0,000 0,04330827 0,08304718 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,04330827 0,08298205 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,04330827 0,08291701 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04330827 0,08285208 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04330827 0,08278725 ! response to dsRNA GO:0043331 23 10 0,000 0,04330827 0,08272253 ! DNA ligation GO:0006266 18 10 0,000 0,04330827 0,0826579 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,04330827 0,08259337 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04330827 0,08252895 ! melanosome localization GO:0032400 16 10 0,000 0,04330827 0,08246462 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04330827 0,0824004 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,04330827 0,08233627 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,04330827 0,08227225 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,04330827 0,08220832 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,04330827 0,0821445 ! induction of an organ GO:0001759 17 10 0,000 0,04330827 0,08208077 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04330827 0,08201714 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04330827 0,08195361 ! protein sumoylation GO:0016925 17 10 0,000 0,04330827 0,08189018 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,04330827 0,08182685 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04330827 0,08176361 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04330827 0,08170047 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04330827 0,08163743 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04330827 0,08157449 ! salivary gland development GO:0007431 28 10 0,000 0,04330827 0,08151164 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04330827 0,08144889 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,04330827 0,08138624 ! midbrain development GO:0030901 14 10 0,000 0,04330827 0,08132368 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04330827 0,08126122 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,04330827 0,08119886 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04330827 0,08113659 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,04330827 0,08107441 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,04330827 0,08101234 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04330827 0,08095035 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04330827 0,08088846 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,04330827 0,08082667 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04330827 0,08076497 ! detection of calcium ion GO:0005513 24 10 0,000 0,04330827 0,08070336 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,04330827 0,08064185 ! blastocyst formation GO:0001825 18 10 0,000 0,04330827 0,08058043 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,04330827 0,08051911 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04330827 0,08045788 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04330827 0,08039674 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04330827 0,0803357 ! response to nicotine GO:0035094 20 10 0,000 0,04330827 0,08027474 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,04330827 0,08021388 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,04361353 0,08071806 ! axon guidance GO:0007411 162 75 1,000 0,04361353 0,08065696 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,04466539 0,08253975 ! learning or memory GO:0007611 161 76 1,000 0,04466539 0,08247736 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,04572662 0,08437321 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,04679712 0,08628329 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,04753523 0,0875781 ! respiratory burst GO:0045730 17 11 0,000 0,04753523 0,0875121 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,04753523 0,08744621 ! neuron fate specification GO:0048665 18 11 0,000 0,04753523 0,08738041 ! telencephalon cell migration GO:0022029 23 11 0,000 0,04753523 0,08731471 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,04753523 0,08724911 ! thyroid gland development GO:0030878 26 11 0,000 0,04753523 0,0871836 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,04753523 0,0871182 ! synapsis GO:0007129 14 11 0,000 0,04753523 0,08705289 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,04753523 0,08698769 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,04753523 0,08692258 ! response to pain GO:0048265 27 11 0,000 0,04753523 0,08685756 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,04753523 0,08679265 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,04753523 0,08672783 ! bone resorption GO:0045453 16 11 0,000 0,04753523 0,08666311 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,04753523 0,08659848 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04753523 0,08653395 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04753523 0,08646952 ! melanocyte differentiation GO:0030318 20 11 0,000 0,04753523 0,08640518 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,04753523 0,08634094 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,04753523 0,08627679 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,04753523 0,08621274 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,04753523 0,08614878 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,04753523 0,08608492 ! UV protection GO:0009650 20 11 0,000 0,04753523 0,08602116 ! adult heart development GO:0007512 16 11 0,000 0,04753523 0,08595748 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,04753523 0,08589391 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04753523 0,08583042 ! macroautophagy GO:0016236 19 11 0,000 0,04753523 0,08576703 ! temperature homeostasis GO:0001659 18 11 0,000 0,04753523 0,08570373 ! behavioral fear response GO:0001662 27 11 0,000 0,04753523 0,08564053 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,04753523 0,08557742 ! negative regulation of ossification GO:0030279 27 11 0,000 0,04753523 0,0855144 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,04753523 0,08545148 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,04753523 0,08538865 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,04753523 0,08532591 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,04753523 0,08526326 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,04753523 0,0852007 ! regulation of organ growth GO:0046620 14 11 0,000 0,04753523 0,08513824 ! pigment granule localization GO:0051875 20 11 0,000 0,04753523 0,08507587 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,04753523 0,08501359 ! vasoconstriction GO:0042310 20 11 0,000 0,04753523 0,0849514 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,04753523 0,0848893 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04753523 0,08482729 ! embryonic axis specification GO:0000578 19 11 0,000 0,04753523 0,08476537 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,04753523 0,08470355 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04753523 0,08464181 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,04753523 0,08458016 ! DNA methylation GO:0006306 19 11 0,000 0,04753523 0,0845186 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,04753523 0,08445714 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,04753523 0,08439576 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,04753523 0,08433447 ! prophase GO:0051324 17 11 0,000 0,04753523 0,08427327 ! nucleosome positioning GO:0016584 15 11 0,000 0,04753523 0,08421215 ! regulation of isotype switching GO:0045191 24 11 0,000 0,04753523 0,08415113 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,04753523 0,0840902 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,04753523 0,08402935 ! apical protein localization GO:0045176 18 11 0,000 0,04753523 0,08396859 ! acid secretion GO:0046717 20 11 0,000 0,04753523 0,08390792 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04753523 0,08384734 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,04753523 0,08378684 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,04753523 0,08372643 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,04753523 0,08366611 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,04753523 0,08360588 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,04753523 0,08354573 ! cholesterol efflux GO:0033344 21 11 0,000 0,04753523 0,08348567 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04753523 0,08342569 ! oocyte development GO:0048599 20 11 0,000 0,04753523 0,0833658 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,04753523 0,083306 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,04753523 0,08324628 ! embryonic gut development GO:0048566 19 11 0,000 0,04753523 0,08318665 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,04753523 0,0831271 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,04753523 0,08306764 ! activation of innate immune response GO:0002218 16 11 0,000 0,04753523 0,08300826 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,04753523 0,08294897 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,04753523 0,08288976 ! lysogeny GO:0030069 22 11 0,000 0,04753523 0,08283064 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04753523 0,0827716 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,04753523 0,08271265 ! sequestering of metal ion GO:0051238 15 11 0,000 0,04753523 0,08265378 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,04787678 0,08318845 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,0489655 0,0850197 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,05006318 0,08686389 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,05116973 0,08872083 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,05174362 0,08965225 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,05174362 0,08958871 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,05174362 0,08952527 ! mating GO:0007618 17 12 0,000 0,05174362 0,08946191 ! protein complex disassembly GO:0043241 28 12 0,000 0,05174362 0,08939864 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05174362 0,08933546 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,05174362 0,08927237 ! T cell proliferation GO:0042098 32 12 0,000 0,05174362 0,08920937 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05174362 0,08914646 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,05174362 0,08908363 ! ventral spinal cord development GO:0021517 25 12 0,000 0,05174362 0,0890209 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,05174362 0,08895825 ! drug transport GO:0015893 16 12 0,000 0,05174362 0,08889569 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,05174362 0,08883322 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,05174362 0,08877084 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,05174362 0,08870854 ! polyamine metabolic process GO:0006595 18 12 0,000 0,05174362 0,08864634 ! mitotic spindle organization GO:0007052 23 12 0,000 0,05174362 0,08858421 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,05174362 0,08852218 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,05174362 0,08846023 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,05174362 0,08839837 ! lipid digestion GO:0044241 21 12 0,000 0,05174362 0,0883366 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,05174362 0,08827491 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05174362 0,08821331 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,05174362 0,0881518 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,05174362 0,08809037 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05174362 0,08802902 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,05174362 0,08796776 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,05174362 0,08790659 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,05174362 0,0878455 ! snRNA metabolic process GO:0016073 30 12 0,000 0,05174362 0,0877845 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,05174362 0,08772358 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,05174362 0,08766274 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05174362 0,08760199 ! cranial nerve development GO:0021545 23 12 0,000 0,05174362 0,08754133 ! fucose catabolic process GO:0019317 25 12 0,000 0,05174362 0,08748074 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,05174362 0,08742025 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,05174362 0,08735983 ! autonomic nervous system development GO:0048483 24 12 0,000 0,05174362 0,0872995 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,05174362 0,08723925 ! zymogen activation GO:0031638 18 12 0,000 0,05174362 0,08717909 ! T cell homeostasis GO:0043029 28 12 0,000 0,05174362 0,087119 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,05174362 0,087059 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,05174362 0,08699909 ! oocyte differentiation GO:0009994 21 12 0,000 0,05174362 0,08693925 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,05174362 0,0868795 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,05174362 0,08681983 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,05174362 0,08676024 ! defense response to fungus GO:0050832 15 12 0,000 0,05174362 0,08670074 ! developmental induction GO:0031128 22 12 0,000 0,05174362 0,08664131 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,05174362 0,08658197 ! lamellipodium assembly GO:0030032 24 12 0,000 0,05174362 0,08652271 ! response to cold GO:0009409 17 12 0,000 0,05174362 0,08646353 ! establishment of cell polarity GO:0030010 21 12 0,000 0,05174362 0,08640443 ! regulation of synapse organization GO:0050807 18 12 0,000 0,05174362 0,08634541 ! localization within membrane GO:0051668 26 12 0,000 0,05174362 0,08628647 ! response to drug GO:0042493 149 83 1,000 0,05228504 0,08712985 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,05228504 0,08707046 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,05228504 0,08701114 ! regulation of ligase activity GO:0051340 147 84 1,000 0,05340902 0,08882113 ! negative regulation of transport GO:0051051 164 85 1,000 0,05454157 0,0906429 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,05454157 0,09058128 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,05568259 0,09241344 GO:0002696|positive regulation of leukocyte activation, ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,05593354 0,0927669 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05593354 0,09270397 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,05593354 0,09264112 ! regulation of chemokine production GO:0032642 18 13 0,000 0,05593354 0,09257835 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05593354 0,09251567 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,05593354 0,09245308 ! peroxisomal transport GO:0043574 28 13 0,000 0,05593354 0,09239057 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,05593354 0,09232814 ! cartilage condensation GO:0001502 22 13 0,000 0,05593354 0,0922658 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,05593354 0,09220354 ! organelle fusion GO:0048284 36 13 0,000 0,05593354 0,09214137 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,05593354 0,09207928 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,05593354 0,09201727 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,05593354 0,09195535 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,05593354 0,09189351 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,05593354 0,09183175 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,05593354 0,09177008 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,05593354 0,09170849 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,05593354 0,09164698 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,05593354 0,09158556 ! methionine metabolic process GO:0006555 31 13 0,000 0,05593354 0,09152421 ! plasma membrane organization GO:0007009 27 13 0,000 0,05593354 0,09146295 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,05593354 0,09140177 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,05593354 0,09134068 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,05593354 0,09127966 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,05593354 0,09121872 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,05593354 0,09115787 ! exocrine system development GO:0035272 34 13 0,000 0,05593354 0,0910971 ! asymmetric protein localization GO:0008105 24 13 0,000 0,05593354 0,09103641 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,05593354 0,0909758 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,05593354 0,09091527 ! L-glutamate transport GO:0015813 30 13 0,000 0,05593354 0,09085482 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,05593354 0,09079445 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,05593354 0,09073416 ! protein homotetramerization GO:0051289 24 13 0,000 0,05593354 0,09067395 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,05593354 0,09061383 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,05593354 0,09055378 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,05593354 0,09049381 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,05593354 0,09043392 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,05593354 0,09037411 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05593354 0,09031438 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,05593354 0,09025472 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,05593354 0,09019515 ! histone methylation GO:0016571 29 13 0,000 0,05593354 0,09013565 ! chromatin silencing GO:0006342 29 13 0,000 0,05593354 0,09007624 ! gland morphogenesis GO:0022612 31 13 0,000 0,05593354 0,0900169 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,05593354 0,08995764 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,05593354 0,08989845 ! regulation of epidermis development GO:0045682 19 13 0,000 0,05593354 0,08983935 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,05593354 0,08978032 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,05593354 0,08972137 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,05593354 0,0896625 ! spleen development GO:0048536 24 13 0,000 0,05593354 0,0896037 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,05593354 0,08954499 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,05593354 0,08948635 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,05593354 0,08942778 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,05593354 0,08936929 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05593354 0,08931088 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,05593354 0,08925255 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,05593354 0,08919429 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,05593354 0,08913611 ! insulin secretion GO:0030073 24 13 0,000 0,05593354 0,089078 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,05593354 0,08901997 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,05593354 0,08896201 ! acrosome reaction GO:0007340 19 13 0,000 0,05593354 0,08890413 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,05593354 0,08884633 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,05593354 0,0887886 ! rRNA transcription GO:0009303 28 14 0,000 0,06010507 0,0953485 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06010507 0,09528662 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,06010507 0,09522483 ! water transport GO:0006833 21 14 0,000 0,06010507 0,09516311 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06010507 0,09510148 ! non-recombinational repair GO:0000726 29 14 0,000 0,06010507 0,09503993 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,06010507 0,09497845 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06010507 0,09491706 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,06010507 0,09485574 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06010507 0,0947945 ! lipid localization GO:0010876 32 14 0,000 0,06010507 0,09473334 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,06010507 0,09467227 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,06010507 0,09461127 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06010507 0,09455034 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06010507 0,0944895 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06010507 0,09442874 ! arginine metabolic process GO:0006525 21 14 0,000 0,06010507 0,09436805 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06010507 0,09430744 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06010507 0,09424691 ! regulation of heart rate GO:0002027 25 14 0,000 0,06010507 0,09418646 ! fear response GO:0042596 34 14 0,000 0,06010507 0,09412608 ! organic alcohol transport GO:0015850 29 14 0,000 0,06010507 0,09406578 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06010507 0,09400556 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,06010507 0,09394542 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,06010507 0,09388535 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06010507 0,09382536 ! bone mineralization GO:0030282 18 14 0,000 0,06010507 0,09376544 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06010507 0,09370561 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06010507 0,09364584 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06010507 0,09358616 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,06010507 0,09352655 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06010507 0,09346702 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,06010507 0,09340756 ! ribosome assembly GO:0042255 18 14 0,000 0,06010507 0,09334818 ! cerebellum development GO:0021549 23 14 0,000 0,06010507 0,09328887 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06010507 0,09322964 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,06010507 0,09317048 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06010507 0,0931114 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06010507 0,0930524 ! NADP metabolic process GO:0006739 24 14 0,000 0,06010507 0,09299347 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,06010507 0,09293461 ! oxygen transport GO:0015671 22 14 0,000 0,06010507 0,09287583 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,06010507 0,09281712 ! male genitalia development GO:0030539 26 14 0,000 0,06010507 0,09275849 ! regulation of axon extension GO:0030516 43 14 0,000 0,06010507 0,09269993 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,06010507 0,09264144 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,06010507 0,09258303 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,06032951 0,09287019 ! gland development GO:0048732 220 91 1,000 0,06151147 0,09463005 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,06389903 0,09824124 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,06425828 0,09873143 ! lactation GO:0007595 30 15 0,000 0,06425828 0,09866937 ! reproductive cellular process GO:0048610 22 15 0,000 0,06425828 0,0986074 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06425828 0,09854549 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,06425828 0,09848367 ! superoxide anion generation GO:0042554 22 15 0,000 0,06425828 0,09842193 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,06425828 0,09836026 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,06425828 0,09829867 ! copper ion transport GO:0006825 22 15 0,000 0,06425828 0,09823715 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,06425828 0,09817572 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,06425828 0,09811436 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,06425828 0,09805307 ! sulfate transport GO:0008272 27 15 0,000 0,06425828 0,09799187 ! response to cAMP GO:0051591 25 15 0,000 0,06425828 0,09793074 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,06425828 0,09786968 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,06425828 0,09780871 ! response to hexose stimulus GO:0009746 25 15 0,000 0,06425828 0,0977478 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,06425828 0,09768698 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,06425828 0,09762623 ! vesicle coating GO:0006901 38 15 0,000 0,06425828 0,09756555 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,06425828 0,09750495 ! regulation of exocytosis GO:0017157 26 15 0,000 0,06425828 0,09744443 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,06425828 0,09738398 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,06425828 0,0973236 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,06425828 0,0972633 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,06425828 0,09720308 ! regulation of vasodilation GO:0042312 27 15 0,000 0,06425828 0,09714293 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,06425828 0,09708285 ! histone deacetylation GO:0016575 24 15 0,000 0,06425828 0,09702285 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,06425828 0,09696292 ! water homeostasis GO:0030104 28 15 0,000 0,06425828 0,09690307 ! cofactor transport GO:0051181 30 15 0,000 0,06425828 0,09684329 ! muscle maintenance GO:0046716 26 15 0,000 0,06425828 0,09678358 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,06425828 0,09672395 ! intestinal absorption GO:0050892 31 15 0,000 0,06425828 0,09666439 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06425828 0,09660491 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,06425828 0,09654549 ! heme biosynthetic process GO:0006783 33 15 0,000 0,06425828 0,09648615 ! cell killing GO:0001906 32 15 0,000 0,06425828 0,09642689 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,06425828 0,09636769 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,06425828 0,09630857 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,06425828 0,09624952 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,06425828 0,09619055 ! actin filament polymerization GO:0030041 27 15 0,000 0,06425828 0,09613164 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,06425828 0,09607281 ! regulation of membrane potential GO:0042391 179 94 1,000 0,06510444 0,09727838 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,06631749 0,09903033 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,06839325 0,10206763 ! positive regulation of cell size GO:0045793 29 16 0,000 0,06839325 0,10200532 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,06839325 0,10194308 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,06839325 0,10188092 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,06839325 0,10181884 ! bone remodeling GO:0046849 28 16 0,000 0,06839325 0,10175683 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,06839325 0,10169489 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06839325 0,10163304 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,06839325 0,10157125 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,06839325 0,10150955 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,06839325 0,10144791 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,06839325 0,10138635 ! startle response GO:0001964 28 16 0,000 0,06839325 0,10132487 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,06839325 0,10126346 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,06839325 0,10120213 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,06839325 0,10114087 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,06839325 0,10107968 ! protein polyubiquitination GO:0000209 41 16 0,000 0,06839325 0,10101857 ! glutamate metabolic process GO:0006536 25 16 0,000 0,06839325 0,10095753 ! pituitary gland development GO:0021983 30 16 0,000 0,06839325 0,10089656 ! response to osmotic stress GO:0006970 27 16 0,000 0,06839325 0,10083567 ! lysosomal transport GO:0007041 31 16 0,000 0,06839325 0,10077486 ! fructose metabolic process GO:0006000 25 16 0,000 0,06839325 0,10071411 ! L-amino acid transport GO:0015807 33 16 0,000 0,06839325 0,10065344 ! stem cell development GO:0048864 46 16 0,000 0,06839325 0,10059284 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,06839325 0,10053232 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,06839325 0,10047187 ! intermediate filament-based process GO:0045103 36 16 0,000 0,06839325 0,10041149 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,06839325 0,10035118 ! negative regulation of immune response GO:0050777 38 16 0,000 0,06839325 0,10029094 ! axon cargo transport GO:0008088 46 16 0,000 0,06839325 0,10023078 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,06839325 0,10017069 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,06839325 0,10011067 ! DNA replication initiation GO:0006270 28 16 0,000 0,06839325 0,10005073 ! neuron recognition GO:0008038 40 16 0,000 0,06839325 0,09999085 ! mRNA splice site selection GO:0006376 44 16 0,000 0,06839325 0,09993105 ! tissue regeneration GO:0042246 27 16 0,000 0,06839325 0,09987132 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,06839325 0,09981166 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,06839325 0,09975207 ! biomineral formation GO:0031214 22 16 0,000 0,06839325 0,09969255 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,06839325 0,0996331 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,06839325 0,09957373 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,06839325 0,09951442 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,06839325 0,09945519 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,06839325 0,09939602 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,06839325 0,09933693 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,06839325 0,0992779 ! peptide hormone processing GO:0016486 27 16 0,000 0,06839325 0,09921895 ! forebrain development GO:0030900 210 98 1,000 0,07000154 0,10149184 ! mRNA transport GO:0051028 185 100 1,000 0,07249411 0,10504336 ! positive regulation of immune response GO:0050778 175 100 1,000 0,07249411 0,1049811 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,07251007 0,104942 ! metencephalon development GO:0022037 32 17 0,000 0,07251007 0,10487987 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,07251007 0,10481781 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,07251007 0,10475582 ! signal complex assembly GO:0007172 47 17 0,000 0,07251007 0,10469391 ! endothelial cell migration GO:0043542 31 17 0,000 0,07251007 0,10463207 ! gene silencing by RNA GO:0031047 38 17 0,000 0,07251007 0,1045703 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,07251007 0,10450861 ! glial cell development GO:0021782 28 17 0,000 0,07251007 0,10444699 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,07251007 0,10438544 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,07251007 0,10432397 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,07251007 0,10426256 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,07251007 0,10420123 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,07251007 0,10413997 ! myoblast differentiation GO:0045445 50 17 0,000 0,07251007 0,10407879 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,07251007 0,10401767 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,07251007 0,10395663 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,07251007 0,10389566 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,07251007 0,10383476 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,07251007 0,10377393 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,07251007 0,10371317 ! NAD metabolic process GO:0019674 33 17 0,000 0,07251007 0,10365248 ! membrane budding GO:0006900 42 17 0,000 0,07251007 0,10359187 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,07251007 0,10353132 ! regulation of protein binding GO:0043393 33 17 0,000 0,07251007 0,10347085 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,07251007 0,10341045 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,07251007 0,10335011 ! genitalia development GO:0048806 32 17 0,000 0,07251007 0,10328985 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,07251007 0,10322966 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,07251007 0,10316954 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,07251007 0,10310948 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,07251007 0,1030495 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,07251007 0,10298959 ! steroid catabolic process GO:0006706 34 17 0,000 0,07251007 0,10292975 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,07251007 0,10286997 ! gas transport GO:0015669 26 17 0,000 0,07251007 0,10281027 ! organic cation transport GO:0015695 32 17 0,000 0,07251007 0,10275063 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,07251007 0,10269107 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,07251007 0,10263157 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,07660881 0,10837019 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,07660881 0,10830747 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,07660881 0,10824483 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,07660881 0,10818226 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,07660881 0,10811977 ! adult walking behavior GO:0007628 36 18 0,000 0,07660881 0,10805734 ! patterning of blood vessels GO:0001569 43 18 0,000 0,07660881 0,10799499 ! heart looping GO:0001947 34 18 0,000 0,07660881 0,10793271 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,07660881 0,1078705 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,07660881 0,10780836 ! centrosome cycle GO:0007098 26 18 0,000 0,07660881 0,1077463 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,07660881 0,1076843 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,07660881 0,10762238 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,07660881 0,10756053 ! glycine metabolic process GO:0006544 30 18 0,000 0,07660881 0,10749875 ! glutamine metabolic process GO:0006541 29 18 0,000 0,07660881 0,10743704 ! response to retinoic acid GO:0032526 31 18 0,000 0,07660881 0,1073754 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,07660881 0,10731383 ! DNA integration GO:0015074 32 18 0,000 0,07660881 0,10725233 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,07660881 0,1071909 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,07660881 0,10712955 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,07660881 0,10706826 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,07660881 0,10700704 ! neural crest cell migration GO:0001755 41 18 0,000 0,07660881 0,10694589 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,07660881 0,10688482 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,07660881 0,10682381 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,07660881 0,10676287 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,07660881 0,106702 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,07660881 0,10664121 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,07660881 0,10658048 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,07660881 0,10651982 ! detection of bacterium GO:0016045 22 18 0,000 0,07660881 0,10645922 ! nerve development GO:0021675 34 18 0,000 0,07660881 0,1063987 ! defense response to virus GO:0051607 43 18 0,000 0,07660881 0,10633825 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,07660881 0,10627786 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,08068955 0,11187546 ! positive regulation of translation GO:0045727 31 19 0,000 0,08068955 0,11181201 ! negative regulation of defense response GO:0031348 27 19 0,000 0,08068955 0,11174862 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,08068955 0,11168531 ! neuron maturation GO:0042551 46 19 0,000 0,08068955 0,11162206 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,08068955 0,11155889 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,08068955 0,1114958 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,08068955 0,11143277 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,08068955 0,11136981 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,08068955 0,11130693 ! inositol metabolic process GO:0006020 33 19 0,000 0,08068955 0,11124411 ! memory GO:0007613 34 19 0,000 0,08068955 0,11118137 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,08068955 0,1111187 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,08068955 0,11105609 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,08068955 0,11099356 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,08068955 0,1109311 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,08068955 0,11086871 ! cerebral cortex development GO:0021987 40 19 0,000 0,08068955 0,11080639 ! response to vitamin A GO:0033189 32 19 0,000 0,08068955 0,11074414 ! heme metabolic process GO:0042168 40 19 0,000 0,08068955 0,11068196 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,08068955 0,11061985 ! response to fungus GO:0009620 26 19 0,000 0,08068955 0,1105578 ! peptide cross-linking GO:0018149 39 19 0,000 0,08068955 0,11049583 ! protein export from nucleus GO:0006611 40 19 0,000 0,08068955 0,11043393 ! heart process GO:0003015 32 19 0,000 0,08068955 0,1103721 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,08068955 0,11031033 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,08068955 0,11024864 ! visual learning GO:0008542 38 19 0,000 0,08068955 0,11018701 ! cellular pigmentation GO:0033059 37 19 0,000 0,08068955 0,11012546 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,08068955 0,11006397 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,08068955 0,11000255 ! vitamin transport GO:0051180 31 19 0,000 0,08068955 0,1099412 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,08068955 0,10987991 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,08068955 0,1098187 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,08068955 0,10975755 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,08068955 0,10969648 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,08068955 0,10963547 ! cilium assembly GO:0042384 38 19 0,000 0,08068955 0,10957452 ! peptide hormone secretion GO:0030072 32 19 0,000 0,08068955 0,10951365 ! protein secretion GO:0009306 45 20 0,000 0,08475237 0,11496393 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,08475237 0,11490013 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,08475237 0,11483641 ! positive regulation of ossification GO:0045778 50 20 0,000 0,08475237 0,11477275 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,08475237 0,11470916 ! skin development GO:0043588 42 20 0,000 0,08475237 0,11464565 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,08475237 0,1145822 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,08475237 0,11451883 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,08475237 0,11445552 ! response to vitamin GO:0033273 36 20 0,000 0,08475237 0,11439229 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,08475237 0,11432912 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,08475237 0,11426603 ! bile acid metabolic process GO:0008206 34 20 0,000 0,08475237 0,114203 ! response to alkaloid GO:0043279 38 20 0,000 0,08475237 0,11414004 ! retinoid metabolic process GO:0001523 34 20 0,000 0,08475237 0,11407716 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,08475237 0,11401434 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,08475237 0,11395159 GO:0032392|DNA geometric change, ! body fluid secretion GO:0007589 33 20 0,000 0,08475237 0,11388891 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,08475237 0,1138263 ! peptide secretion GO:0002790 38 20 0,000 0,08475237 0,11376376 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,08475237 0,11370128 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,08475237 0,11363888 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,08475237 0,11357654 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,08475237 0,11351428 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,08475237 0,11345208 ! cell-cell junction organization GO:0045216 43 20 0,000 0,08475237 0,11338995 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,08475237 0,11332788 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,08475237 0,11326589 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,08475237 0,11320396 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,08475237 0,1131421 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,08475237 0,11308031 ! regulation of glucose import GO:0046324 30 20 0,000 0,08475237 0,11301858 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,08475237 0,11295692 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,08475237 0,11289533 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,08475237 0,11283381 ! regulation of cell killing GO:0031341 46 21 0,000 0,08879735 0,11815464 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,08879735 0,11809032 ! hormone secretion GO:0046879 39 21 0,000 0,08879735 0,11802608 ! cAMP metabolic process GO:0046058 41 21 0,000 0,08879735 0,1179619 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,08879735 0,11789779 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,08879735 0,11783375 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,08879735 0,11776978 ! ovarian follicle development GO:0001541 39 21 0,000 0,08879735 0,11770587 ! smooth muscle contraction GO:0006939 48 21 0,000 0,08879735 0,11764204 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,08879735 0,11757828 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,08879735 0,11751459 ! plasma membrane fusion GO:0045026 33 21 0,000 0,08879735 0,11745096 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,08879735 0,11738741 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,08879735 0,11732392 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,08879735 0,1172605 ! sensory perception of pain GO:0019233 33 21 0,000 0,08879735 0,11719715 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,08879735 0,11713387 ! diencephalon development GO:0021536 36 21 0,000 0,08879735 0,11707066 ! collagen fibril organization GO:0030199 62 21 0,000 0,08879735 0,11700751 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,08879735 0,11694443 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,08879735 0,11688143 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,08879735 0,11681848 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,08879735 0,11675561 ! collagen catabolic process GO:0030574 29 21 0,000 0,08879735 0,11669281 ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,08879735 0,11663007 ! sperm-egg recognition GO:0035036 23 21 0,000 0,08879735 0,1165674 ! actin filament-based movement GO:0030048 47 21 0,000 0,08879735 0,11650479 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,09282457 0,12172325 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,09282457 0,12165795 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,09282457 0,12159272 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,09282457 0,12152755 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,09282457 0,12146246 ! microtubule-based transport GO:0010970 59 22 0,000 0,09282457 0,12139744 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,09282457 0,12133249 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,09282457 0,1212676 ! vacuolar transport GO:0007034 41 22 0,000 0,09282457 0,12120279 ! central nervous system neuron development GO:0021954 47 22 0,000 0,09282457 0,12113804 ! fucose metabolic process GO:0006004 44 22 0,000 0,09282457 0,12107337 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,09282457 0,12100876 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,09282457 0,12094422 ! ureteric bud development GO:0001657 50 22 0,000 0,09282457 0,12087975 ! stem cell differentiation GO:0048863 57 22 0,000 0,09282457 0,12081535 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,09282457 0,12075102 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,09282457 0,12068676 ! cytolysis GO:0019835 27 22 0,000 0,09282457 0,12062256 ! renal system process GO:0003014 42 22 0,000 0,09282457 0,12055844 ! vasodilation GO:0042311 40 22 0,000 0,09282457 0,12049438 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,09282457 0,12043039 ! G1 phase GO:0051318 44 22 0,000 0,09282457 0,12036646 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,09282457 0,12030261 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,09282457 0,12023882 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,09282457 0,1201751 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,09282457 0,12011145 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,09282457 0,12004786 ! sarcomere organization GO:0045214 32 22 0,000 0,09282457 0,11998435 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,09282457 0,1199209 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,09282457 0,11985751 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,09282457 0,1197942 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,09282457 0,11973095 ! gut development GO:0048565 44 22 0,000 0,09282457 0,11966777 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,09282457 0,11960465 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,09282457 0,1195416 ! protein stabilization GO:0050821 41 22 0,000 0,09282457 0,11947862 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,0968341 0,12457383 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,0968341 0,12450826 ! gluconeogenesis GO:0006094 38 23 0,000 0,0968341 0,12444277 ! glycerol metabolic process GO:0006071 40 23 0,000 0,0968341 0,12437734 ! viral genome replication GO:0019079 44 23 0,000 0,0968341 0,12431198 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,0968341 0,12424669 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,0968341 0,12418147 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,0968341 0,12411632 ! regeneration GO:0031099 42 23 0,000 0,0968341 0,12405123 ! axis specification GO:0009798 43 23 0,000 0,0968341 0,12398622 ! visual behavior GO:0007632 46 23 0,000 0,0968341 0,12392127 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,0968341 0,12385639 ! response to ethanol GO:0045471 47 23 0,000 0,0968341 0,12379157 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,0968341 0,12372683 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,0968341 0,12366215 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,0968341 0,12359754 ! peroxisome organization GO:0007031 43 23 0,000 0,0968341 0,123533 ! lysosome organization GO:0007040 47 23 0,000 0,0968341 0,12346853 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,0968341 0,12340412 ! vesicle targeting GO:0006903 49 23 0,000 0,0968341 0,12333978 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,0968341 0,12327551 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,0968341 0,1232113 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,0968341 0,12314716 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,0968341 0,12308309 ! DNA modification GO:0006304 36 23 0,000 0,0968341 0,12301908 ! fatty acid transport GO:0015908 47 23 0,000 0,0968341 0,12295515 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,0968341 0,12289127 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,0968341 0,12282747 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,0968341 0,12276373 ! hormone transport GO:0009914 41 23 0,000 0,0968341 0,12270005 ! cell-cell recognition GO:0009988 28 23 0,000 0,0968341 0,12263644 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,0968341 0,1225729 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,0968341 0,12250943 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,0968341 0,12244601 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,10082602 0,12742781 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,10082602 0,12736193 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,10082602 0,12729611 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,10082602 0,12723035 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,10082602 0,12716467 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,10082602 0,12709905 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,10082602 0,1270335 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,10082602 0,12696802 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,10082602 0,12690261 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,10082602 0,12683726 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,10082602 0,12677198 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,10082602 0,12670677 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,10082602 0,12664163 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,10082602 0,12657655 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,10082602 0,12651154 ! membrane depolarization GO:0051899 45 24 0,000 0,10082602 0,12644659 ! oogenesis GO:0048477 44 24 0,000 0,10082602 0,12638172 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,10082602 0,1263169 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,10082602 0,12625216 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,10082602 0,12618748 ! platelet activation GO:0030168 41 24 0,000 0,10082602 0,12612287 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,10082602 0,12605832 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,10082602 0,12599384 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,10082602 0,12592943 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,10082602 0,12586508 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,10082602 0,1258008 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,10082602 0,12573658 ! regulation of amine transport GO:0051952 41 24 0,000 0,10082602 0,12567243 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,10480041 0,13055961 ! leukocyte adhesion GO:0007159 55 25 0,000 0,10480041 0,13049307 ! phototransduction GO:0007602 37 25 0,000 0,10480041 0,13042659 ! keratinization GO:0031424 37 25 0,000 0,10480041 0,13036018 ! vacuole organization GO:0007033 49 25 0,000 0,10480041 0,13029384 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,10480041 0,13022757 ! receptor metabolic process GO:0043112 53 25 0,000 0,10480041 0,13016136 ! chromosome condensation GO:0030261 48 25 0,000 0,10480041 0,13009522 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,10480041 0,13002915 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,10480041 0,12996315 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,10480041 0,12989721 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,10480041 0,12983134 ! immunoglobulin production GO:0002377 62 25 0,000 0,10480041 0,12976553 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,10480041 0,1296998 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,10480041 0,12963413 ! liver development GO:0001889 55 25 0,000 0,10480041 0,12956852 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,10875734 0,13439261 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,10875734 0,13432466 ! molting cycle process GO:0022404 52 26 0,000 0,10875734 0,13425679 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,10875734 0,13418898 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,10875734 0,13412125 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,10875734 0,13405358 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,10875734 0,13398597 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,10875734 0,13391844 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,10875734 0,13385098 ! digestive system process GO:0022600 49 26 0,000 0,10875734 0,13378358 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,10875734 0,13371625 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,10875734 0,13364899 ! osteoblast differentiation GO:0001649 63 26 0,000 0,10875734 0,13358179 ! neural crest cell development GO:0014032 59 26 0,000 0,10875734 0,13351467 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,10875734 0,13344761 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,10875734 0,13338062 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,10875734 0,13331369 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,10875734 0,13324683 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,10875734 0,13318004 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,10875734 0,13311332 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,10875734 0,13304666 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,10875734 0,13298007 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,10875734 0,13291355 ! blastocyst development GO:0001824 50 26 0,000 0,10875734 0,13284709 ! telomere organization GO:0032200 46 26 0,000 0,10875734 0,1327807 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,10875734 0,13271438 ! neural tube closure GO:0001843 58 26 0,000 0,10875734 0,13264812 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,10875734 0,13258193 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,10875734 0,1325158 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,10875734 0,13244974 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,1126969 0,13717913 ! embryonic pattern specification GO:0009880 49 27 0,000 0,1126969 0,13711082 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,1126969 0,13704257 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,1126969 0,13697439 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,1126969 0,13690627 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,1126969 0,13683823 ! iron ion transport GO:0006826 65 27 0,000 0,1126969 0,13677025 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,1126969 0,13670234 ! superoxide metabolic process GO:0006801 41 27 0,000 0,1126969 0,1366345 ! tube lumen formation GO:0035148 59 27 0,000 0,1126969 0,13656673 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,1126969 0,13649902 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,1126969 0,13643138 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,1126969 0,1363638 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,1126969 0,1362963 ! leukocyte proliferation GO:0070661 59 27 0,000 0,1126969 0,13622886 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,11661915 0,14090038 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,11661915 0,14083074 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,11661915 0,14076116 ! vesicle docking GO:0048278 55 28 0,000 0,11661915 0,14069164 ! circadian rhythm GO:0007623 56 28 0,000 0,11661915 0,1406222 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,11661915 0,14055283 ! fat cell differentiation GO:0045444 57 28 0,000 0,11661915 0,14048352 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,11661915 0,14041428 ! sperm motility GO:0030317 37 28 0,000 0,11661915 0,14034511 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,11661915 0,14027601 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,11661915 0,14020698 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,11661915 0,14013801 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,11661915 0,14006911 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,11661915 0,14000028 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,11661915 0,13993152 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,11661915 0,13986283 ! glutathione metabolic process GO:0006749 42 28 0,000 0,11661915 0,1397942 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,11661915 0,13972564 ! lipid oxidation GO:0034440 48 28 0,000 0,11661915 0,13965715 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,11661915 0,13958872 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,11661915 0,13952036 ! translational initiation GO:0006413 66 29 0,000 0,12052417 0,14412166 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,12052417 0,14405115 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,12052417 0,14398071 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,12052417 0,14391034 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,12052417 0,14384003 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,12052417 0,1437698 ! primary neural tube formation GO:0014020 61 29 0,000 0,12052417 0,14369963 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,12052417 0,14362954 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,12052417 0,14355951 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,12052417 0,14348955 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,12052417 0,14341965 ! synaptogenesis GO:0007416 46 29 0,000 0,12052417 0,14334983 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,12052417 0,14328007 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,12052417 0,14321038 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,12052417 0,14314076 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,12441204 0,1476864 ! phenol metabolic process GO:0018958 56 30 0,000 0,12441204 0,14761467 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,12441204 0,14754302 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,12441204 0,14747143 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,12441204 0,14739991 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,12441204 0,14732846 ! acute-phase response GO:0006953 50 30 0,000 0,12441204 0,14725708 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,12441204 0,14718577 ! myofibril assembly GO:0030239 50 30 0,000 0,12441204 0,14711453 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,12441204 0,14704336 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,12441204 0,14697225 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,12441204 0,14690122 ! cell fate determination GO:0001709 64 30 0,000 0,12441204 0,14683025 ! phospholipid transport GO:0015914 65 30 0,000 0,12441204 0,14675935 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,12441204 0,14668852 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,12441204 0,14661776 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,12441204 0,14654707 ! regulation of coagulation GO:0050818 52 30 0,000 0,12441204 0,14647644 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,12828283 0,15096096 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,12828283 0,15088828 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,12828283 0,15081567 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,12828283 0,15074313 ! regulation of innate immune response GO:0045088 57 31 0,000 0,12828283 0,15067065 ! ovulation cycle process GO:0022602 55 31 0,000 0,12828283 0,15059825 ! peptide transport GO:0015833 60 31 0,000 0,12828283 0,15052592 ! male gonad development GO:0008584 56 31 0,000 0,12828283 0,15045365 ! iron ion homeostasis GO:0055072 60 31 0,000 0,12828283 0,15038146 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,12828283 0,15030933 ! detection of light stimulus GO:0009583 44 31 0,000 0,12828283 0,15023728 ! natural killer cell activation GO:0030101 50 31 0,000 0,12828283 0,15016529 ! cofactor catabolic process GO:0051187 54 31 0,000 0,12828283 0,15009337 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,12828283 0,15002152 ! eye morphogenesis GO:0048592 65 31 0,000 0,12828283 0,14994974 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,12828283 0,14987803 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,13213662 0,15430677 ! collagen metabolic process GO:0032963 49 32 0,000 0,13213662 0,15423305 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,13213662 0,15415939 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,13213662 0,15408581 ! metanephros development GO:0001656 81 32 0,000 0,13213662 0,15401229 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,13213662 0,15393885 ! muscle cell development GO:0055001 52 32 0,000 0,13213662 0,15386547 ! mesoderm formation GO:0001707 73 32 0,000 0,13213662 0,15379217 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,13213662 0,15371894 ! ovulation cycle GO:0042698 57 32 0,000 0,13213662 0,15364577 ! BMP signaling pathway GO:0030509 71 32 0,000 0,13213662 0,15357268 ! hindbrain development GO:0030902 65 32 0,000 0,13213662 0,15349965 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,13213662 0,15342669 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,13213662 0,15335381 ! gene silencing GO:0016458 71 32 0,000 0,13213662 0,15328099 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,13597348 0,15765696 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,13597348 0,15758217 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,13597348 0,15750745 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,13597348 0,1574328 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,13597348 0,15735823 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,13597348 0,15728372 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,13597348 0,15720928 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,13597348 0,15713492 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,13597348 0,15706062 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,13597348 0,1569864 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,13979348 0,16132049 ! glial cell differentiation GO:0010001 67 34 0,000 0,13979348 0,16124433 ! post-embryonic development GO:0009791 76 34 0,000 0,13979348 0,16116823 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,13979348 0,16109221 ! cholesterol transport GO:0030301 62 34 0,000 0,13979348 0,16101626 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,13979348 0,16094038 ! spliceosome assembly GO:0000245 75 34 0,000 0,13979348 0,16086457 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,13979348 0,16078883 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,13979348 0,16071317 ! formation of primary germ layer GO:0001704 76 34 0,000 0,13979348 0,16063757 ! cell fate specification GO:0001708 56 34 0,000 0,13979348 0,16056205 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,13979348 0,1604866 ! adult locomotory behavior GO:0008344 62 34 0,000 0,13979348 0,16041122 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,14359671 0,16469801 ! negative regulation of secretion GO:0051048 68 35 0,000 0,14359671 0,16462072 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,14359671 0,16454351 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,14359671 0,16446636 ! membrane docking GO:0022406 69 35 0,000 0,14359671 0,1643893 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,14359671 0,1643123 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,14359671 0,16423537 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,14359671 0,16415852 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,14359671 0,16408174 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,14359671 0,16400503 ! ceramide metabolic process GO:0006672 72 35 0,000 0,14359671 0,16392839 ! sterol transport GO:0015918 63 35 0,000 0,14359671 0,16385182 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,14359671 0,16377533 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,14359671 0,16369891 ! placenta development GO:0001890 53 35 0,000 0,14359671 0,16362255 ! vesicle localization GO:0051648 70 35 0,000 0,14359671 0,16354627 ! regulation of muscle development GO:0048634 82 36 0,000 0,14738322 0,16778062 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,14738322 0,16770247 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,14738322 0,1676244 ! positive regulation of cell development GO:0010720 85 36 0,000 0,14738322 0,1675464 ! protein targeting to membrane GO:0006612 75 36 0,000 0,14738322 0,16746847 ! regulation of proteolysis GO:0030162 77 36 0,000 0,14738322 0,16739061 ! aerobic respiration GO:0009060 56 36 0,000 0,14738322 0,16731283 ! cytokine production GO:0001816 68 36 0,000 0,14738322 0,16723512 ! embryonic organ development GO:0048568 67 36 0,000 0,14738322 0,16715748 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,14738322 0,16707991 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,14738322 0,16700242 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,1511531 0,17119472 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! odontogenesis GO:0042476 74 37 0,000 0,1511531 0,17111539 ! actomyosin structure organization GO:0031032 68 37 0,000 0,1511531 0,17103614 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,1511531 0,17095695 ! female gonad development GO:0008585 71 37 0,000 0,1511531 0,17087784 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,1511531 0,17079881 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,15490641 0,17495902 ! organic anion transport GO:0015711 82 38 0,000 0,15490641 0,17487817 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,15490641 0,1747974 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,15490641 0,1747167 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,15490641 0,17463607 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,15490641 0,17455552 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,15490641 0,17447504 ! spermatid development GO:0007286 69 38 0,000 0,15490641 0,17439464 ! pigment metabolic process GO:0042440 87 38 0,000 0,15490641 0,17431431 ! neural tube formation GO:0001841 79 38 0,000 0,15490641 0,17423406 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,15864324 0,17835501 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,15864324 0,17827297 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,15864324 0,178191 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,15864324 0,17810911 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,15864324 0,1780273 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,15864324 0,17794556 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,15864324 0,1778639 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,16236364 0,18195155 ! learning GO:0007612 82 40 0,000 0,16236364 0,18186813 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,16236364 0,18178478 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,16236364 0,1817015 ! mismatch repair GO:0006298 58 40 0,000 0,16236364 0,18161831 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,16236364 0,18153519 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,16236364 0,18145214 ! RNA export from nucleus GO:0006405 61 41 0,000 0,1660677 0,18550681 ! mRNA catabolic process GO:0006402 79 41 0,000 0,1660677 0,18542203 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,1660677 0,18533732 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,1660677 0,18525269 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,1660677 0,18516814 ! gliogenesis GO:0042063 91 41 0,000 0,1660677 0,18508367 ! feeding behavior GO:0007631 69 41 0,000 0,1660677 0,18499927 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,1660677 0,18491495 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,1660677 0,18483071 ! spermatid differentiation GO:0048515 73 41 0,000 0,1660677 0,18474654 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,1660677 0,18466245 ! RNA modification GO:0009451 64 41 0,000 0,1660677 0,18457843 ! ear morphogenesis GO:0042471 64 42 0,000 0,16975549 0,18859148 ! organic ether metabolic process GO:0018904 59 42 0,000 0,16975549 0,18850575 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,16975549 0,18842011 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,16975549 0,18833454 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,16975549 0,18824905 ! regulation of protein secretion GO:0050708 77 42 0,000 0,16975549 0,18816364 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,16975549 0,1880783 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,17342707 0,19205908 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,17342707 0,19197205 ! regulation of tube size GO:0035150 76 43 0,000 0,17342707 0,19188511 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,17342707 0,19179824 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,17342707 0,19171146 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,17342707 0,19162475 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,17342707 0,19153812 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,17342707 0,19145157 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,17342707 0,1913651 ! ion transmembrane transport GO:0034220 79 43 0,000 0,17342707 0,1912787 ! neuron migration GO:0001764 85 43 0,000 0,17342707 0,19119238 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,17342707 0,19110614 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,17708251 0,19504625 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,17708251 0,19495835 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,17708251 0,19487053 ! striated muscle contraction GO:0006941 85 44 0,000 0,17708251 0,19478279 ! phagocytosis GO:0006909 105 44 0,000 0,17708251 0,19469513 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,17708251 0,19460755 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,18072189 0,1985178 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,18072189 0,19842858 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,18072189 0,19833944 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,18072189 0,19825037 ! biopolymer methylation GO:0043414 91 45 0,000 0,18072189 0,19816139 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,18072189 0,19807249 ! female gamete generation GO:0007292 71 45 0,000 0,18072189 0,19798367 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,18072189 0,19789493 ! polyol metabolic process GO:0019751 77 45 0,000 0,18072189 0,19780626 ! developmental growth GO:0048589 88 45 0,000 0,18072189 0,19771768 ! maintenance of location in cell GO:0051651 101 45 0,000 0,18072189 0,19762918 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,18434528 0,20150135 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,18434528 0,20141123 ! glycolysis GO:0006096 71 46 0,000 0,18434528 0,2013212 ! leukocyte migration GO:0050900 75 46 0,000 0,18434528 0,20123124 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,18434528 0,20114137 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,18434528 0,20105157 ! cell growth GO:0016049 90 46 0,000 0,18434528 0,20096186 ! neural tube development GO:0021915 91 47 0,000 0,18795275 0,2048031 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,18795275 0,2047118 ! positive regulation of defense response GO:0031349 88 48 0,000 0,19154436 0,20853069 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,19154436 0,2084378 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,19154436 0,208345 ! endosome transport GO:0016197 127 48 0,000 0,19154436 0,20825228 ! male sex differentiation GO:0046661 93 48 0,000 0,19154436 0,20815964 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,19154436 0,20806708 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,19154436 0,20797461 ! methylation GO:0032259 97 48 0,000 0,19154436 0,20788221 ! response to calcium ion GO:0051592 94 49 0,000 0,19512018 0,21166901 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,19512018 0,21157506 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,19512018 0,21148119 ! JNK cascade GO:0007254 106 49 0,000 0,19512018 0,21138741 ! regulation of ion transport GO:0043269 86 50 0,000 0,19868029 0,21514892 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,19868029 0,21505359 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,19868029 0,21495835 ! regulation of ossification GO:0030278 123 50 0,000 0,19868029 0,2148632 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,19868029 0,21476812 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,19868029 0,21467313 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,19868029 0,21457823 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,20222476 0,2183098 ! peptide metabolic process GO:0006518 80 51 0,000 0,20222476 0,21821338 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,20222476 0,21811703 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,20575364 0,22182531 ! Notch signaling pathway GO:0007219 111 52 0,000 0,20575364 0,22172746 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,20575364 0,2216297 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,20575364 0,22153202 ! excretion GO:0007588 87 52 0,000 0,20575364 0,22143443 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,20575364 0,22133692 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,20575364 0,2212395 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,20575364 0,22114217 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,20575364 0,22104492 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,20926702 0,22472058 ! inner ear development GO:0048839 89 53 0,000 0,20926702 0,22462185 ! chromatin remodeling GO:0006338 122 53 0,000 0,20926702 0,2245232 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,20926702 0,22442464 ! vesicle organization GO:0016050 127 53 0,000 0,20926702 0,22432616 ! cartilage development GO:0051216 99 53 0,000 0,20926702 0,22422777 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,21276495 0,22787583 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,21276495 0,22777597 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,21276495 0,2276762 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,21276495 0,22757652 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,21276495 0,22747692 ! membrane fusion GO:0006944 122 54 0,000 0,21276495 0,22737741 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,21276495 0,22727799 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,21276495 0,22717866 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,21276495 0,22707941 ! RNA catabolic process GO:0006401 103 55 0,000 0,2162475 0,23069548 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,2162475 0,23059478 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,2162475 0,23049418 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,2162475 0,23039366 ! cell recognition GO:0008037 98 55 0,000 0,2162475 0,23029322 ! cell maturation GO:0048469 107 55 0,000 0,2162475 0,23019288 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,2162475 0,23009262 ! glucose catabolic process GO:0006007 88 56 0,000 0,21971475 0,23368008 ! RNA elongation GO:0006354 90 56 0,000 0,21971475 0,23357839 ! chloride transport GO:0006821 102 57 0,000 0,22316676 0,23714501 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,22316676 0,23704191 ! regulation of actin filament length GO:0030832 118 58 0,000 0,22660359 0,24058782 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,22660359 0,2404833 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,22660359 0,24037888 ! gastrulation GO:0007369 122 58 0,000 0,22660359 0,24027455 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,22660359 0,24017031 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,22660359 0,24006616 ! maintenance of location GO:0051235 124 58 0,000 0,22660359 0,2399621 ! nuclear export GO:0051168 110 59 0,000 0,23002531 0,24348 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,23343199 0,24697893 ! regulation of endocytosis GO:0030100 104 60 0,000 0,23343199 0,24687201 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,23343199 0,24676519 ! adult behavior GO:0030534 104 60 0,000 0,23343199 0,24665846 ! kidney development GO:0001822 133 60 0,000 0,23343199 0,24655182 ! positive regulation of secretion GO:0051047 110 61 0,000 0,23682369 0,25002605 ! regulation of cellular component size GO:0032535 125 61 0,000 0,23682369 0,24991805 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,23682369 0,24981014 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,23682369 0,24970232 ! regulation of heart contraction GO:0008016 123 61 0,000 0,23682369 0,2495946 ! camera-type eye development GO:0043010 126 61 0,000 0,23682369 0,24948697 ! proton transport GO:0015992 117 61 0,000 0,23682369 0,24937943 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,23682369 0,24927199 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,24020048 0,25271739 ! tRNA processing GO:0008033 102 62 0,000 0,24020048 0,2526086 ! mesoderm development GO:0007498 128 63 0,000 0,24356243 0,256034 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,24356243 0,25592388 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,24356243 0,25581385 ! hydrogen transport GO:0006818 121 64 0,000 0,24690959 0,25921793 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,24690959 0,25910659 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,24690959 0,25899533 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,25024204 0,26237824 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,25024204 0,26226568 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,25024204 0,26215322 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,25024204 0,26204085 ! ear development GO:0043583 114 66 0,000 0,25355983 0,26540131 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,25355983 0,26528765 ! gonad development GO:0008406 115 66 0,000 0,25355983 0,26517409 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,25686304 0,26851365 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,25686304 0,2683988 ! secondary metabolic process GO:0019748 125 67 0,000 0,25686304 0,26828405 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,26015172 0,27160284 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,26015172 0,27148682 ! hexose catabolic process GO:0019320 113 68 0,000 0,26015172 0,2713709 ! extracellular matrix organization GO:0030198 146 68 0,000 0,26015172 0,27125508 ! detection of external stimulus GO:0009581 102 68 0,000 0,26015172 0,27113935 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,26015172 0,27102373 ! regulation of lipase activity GO:0060191 137 68 0,000 0,26015172 0,2709082 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,26015172 0,27079278 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,26342594 0,27408414 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,26342594 0,27396746 ! urogenital system development GO:0001655 149 69 0,000 0,26342594 0,27385088 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,26342594 0,27373439 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,26342594 0,27361801 ! developmental maturation GO:0021700 128 69 0,000 0,26342594 0,27350173 ! single fertilization GO:0007338 83 69 0,000 0,26342594 0,27338554 ! cell redox homeostasis GO:0045454 114 70 0,000 0,26668576 0,27665108 ! germ cell development GO:0007281 133 70 0,000 0,26668576 0,27653366 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,26993124 0,27978024 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,26993124 0,27966159 ! appendage morphogenesis GO:0035107 150 72 0,000 0,27316245 0,28288931 GO:0035108|limb morphogenesis, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,27316245 0,28276944 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,27316245 0,28264967 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,27316245 0,28253001 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,27316245 0,28241044 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,27316245 0,28229098 ! appendage development GO:0048736 151 73 0,000 0,27637945 0,28549472 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,27637945 0,28537405 ! regulation of immune effector process GO:0002697 156 73 0,000 0,27637945 0,28525349 ! amino acid transport GO:0006865 148 74 0,000 0,27958231 0,28843732 ! transition metal ion transport GO:0000041 143 75 0,000 0,28277108 0,29160394 ! reproductive structure development GO:0048608 131 75 0,000 0,28277108 0,2914809 ! eye development GO:0001654 155 75 0,000 0,28277108 0,29135797 ! rhythmic process GO:0048511 142 75 0,000 0,28277108 0,29123513 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,28594582 0,2943808 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,28594582 0,2942568 ! regulation of blood pressure GO:0008217 134 76 0,000 0,28594582 0,2941329 ! amine catabolic process GO:0009310 136 77 0,000 0,2891066 0,29725901 ! neurotransmitter transport GO:0006836 142 77 0,000 0,2891066 0,29713396 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,2891066 0,29700901 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,2891066 0,29688416 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,2891066 0,29675942 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,2891066 0,29663478 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,29225347 0,29973771 ! antigen processing and presentation GO:0019882 117 78 0,000 0,29225347 0,29961193 ! fertilization GO:0009566 99 78 0,000 0,29225347 0,29948626 ! blood coagulation GO:0007596 151 79 0,000 0,29538651 0,30256991 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,29538651 0,3024431 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,29538651 0,3023164 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,29538651 0,3021898 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,29538651 0,30206331 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,29850576 0,30512535 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,29850576 0,30499773 ! muscle cell differentiation GO:0042692 178 81 0,000 0,30161129 0,30804197 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,30161129 0,30791324 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,30778143 0,31408105 ! exocytosis GO:0006887 153 83 0,000 0,30778143 0,31394991 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,30778143 0,31381888 ! inorganic anion transport GO:0015698 156 83 0,000 0,30778143 0,31368796 ! response to metal ion GO:0010038 158 84 0,000 0,31084616 0,31667939 ! response to nutrient GO:0007584 135 84 0,000 0,31084616 0,31654738 ! digestion GO:0007586 130 84 0,000 0,31084616 0,31641549 ! hemostasis GO:0007599 165 85 0,000 0,31389741 0,31938832 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,31389741 0,31925536 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,31389741 0,3191225 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,31389741 0,31898975 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,31693523 0,32194294 ! regulation of lyase activity GO:0051339 169 86 0,000 0,31693523 0,32180913 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,31995969 0,32474512 ! alcohol catabolic process GO:0046164 142 87 0,000 0,31995969 0,32461026 ! nucleosome assembly GO:0006334 126 87 0,000 0,31995969 0,32447551 ! cellular respiration GO:0045333 143 88 0,000 0,32297083 0,32739326 ! amine biosynthetic process GO:0009309 146 88 0,000 0,32297083 0,32725747 ! sensory perception of smell GO:0007608 117 88 0,000 0,32297083 0,32712179 ! chromatin assembly GO:0031497 128 88 0,000 0,32297083 0,32698622 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,32297083 0,32685077 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,32596874 0,32974808 ! tube morphogenesis GO:0035239 194 89 0,000 0,32596874 0,3296116 ! cellular defense response GO:0006968 123 89 0,000 0,32596874 0,32947523 ! regulation of neurological system process GO:0031644 175 89 0,000 0,32596874 0,32933897 ! response to inorganic substance GO:0010035 173 90 0,000 0,32895345 0,33221714 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,32895345 0,33207986 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,33192502 0,33494128 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,33192502 0,33480299 ! defense response to bacterium GO:0042742 112 91 0,000 0,33192502 0,33466481 ! bone development GO:0060348 206 92 0,000 0,33488353 0,33750844 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,33488353 0,33736926 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,33782901 0,34019632 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,33782901 0,34005615 ! vitamin metabolic process GO:0006766 153 93 0,000 0,33782901 0,33991609 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,34076153 0,34272558 ! female pregnancy GO:0007565 166 94 0,000 0,34076153 0,34258454 ! sterol metabolic process GO:0016125 166 94 0,000 0,34076153 0,34244361 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,34076153 0,34230281 ! regulation of defense response GO:0031347 171 95 0,000 0,34368115 0,34509373 ! nucleosome organization GO:0034728 143 95 0,000 0,34368115 0,34495195 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,34368115 0,34481029 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,34368115 0,34466874 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,34368115 0,34452731 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,34368115 0,34438599 ! sex differentiation GO:0007548 171 96 0,000 0,34658792 0,34715633 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,3494819 0,34991159 ! transcription initiation GO:0006352 171 97 0,000 0,3494819 0,34976824 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,35236314 0,35250743 ! hormone metabolic process GO:0042445 171 100 0,000 0,35808763 0,35808763