pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6830-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 7,000 1,812E-09 4,168E-06 ! negative regulation of phosphorylation GO:0042326 41 23 5,000 8,046E-09 9,253E-06 ! positive regulation of glycolysis GO:0045821 11 5 3,000 1,015E-08 7,783E-06 ! positive regulation of cellular catabolic process GO:0031331 22 12 4,000 1,024E-08 5,887E-06 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 1,396E-08 6,422E-06 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of catabolic process GO:0009896 40 28 5,000 2,921E-08 1,12E-05 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 3,000 3,029E-08 9,954E-06 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 1,131E-07 3,251E-05 ! negative regulation of kinase activity GO:0033673 100 58 6,000 1,279E-07 3,268E-05 ! induction of positive chemotaxis GO:0050930 14 8 3,000 1,399E-07 3,217E-05 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 3,000 1,399E-07 2,925E-05 ! negative regulation of transferase activity GO:0051348 105 61 6,000 1,825E-07 3,497E-05 ! positive regulation of glucose metabolic process GO:0010907 15 9 3,000 2,505E-07 4,432E-05 ! regulation of glycolysis GO:0006110 15 9 3,000 2,505E-07 4,115E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 2,784E-07 4,269E-05 ! regulation of B cell proliferation GO:0030888 15 10 3,000 4,153E-07 5,97E-05 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 3,000 4,153E-07 5,618E-05 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 4,153E-07 5,306E-05 ! glutathione biosynthetic process GO:0006750 11 10 3,000 4,153E-07 5,027E-05 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 3,000 4,153E-07 4,776E-05 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of catabolic process GO:0009894 106 70 6,000 4,767E-07 5,22E-05 ! regulation of cellular catabolic process GO:0031329 36 24 4,000 5,147E-07 5,381E-05 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 5,147E-07 5,147E-05 ! regulation of oxidoreductase activity GO:0051341 39 24 4,000 5,147E-07 4,933E-05 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 3,000 6,491E-07 5,972E-05 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 6,491E-07 5,742E-05 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of endothelial cell proliferation GO:0001938 18 11 3,000 6,491E-07 5,53E-05 ! response to UV GO:0009411 75 46 5,000 6,572E-07 5,398E-05 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 3,000 9,686E-07 7,682E-05 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! positive regulation of cell migration GO:0030335 92 51 5,000 1,229E-06 9,422E-05 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 1,392E-06 1,033E-04 ! regulation of monooxygenase activity GO:0032768 26 13 3,000 1,392E-06 1E-04 ! positive regulation of cell motion GO:0051272 99 56 5,000 2,155E-06 1,502E-04 ! regulation of protein stability GO:0031647 48 32 4,000 2,335E-06 1,579E-04 ! cardiac muscle tissue development GO:0048738 23 15 3,000 2,629E-06 1,728E-04 ! positive regulation of oxidoreductase activity GO:0051353 21 15 3,000 2,629E-06 1,68E-04 ! peptide biosynthetic process GO:0043043 19 15 3,000 2,629E-06 1,634E-04 ! lung development GO:0030324 94 59 5,000 2,942E-06 1,78E-04 ! regulation of hormone biosynthetic process GO:0046885 7 5 2,000 3,045E-06 1,796E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 3,045E-06 1,751E-04 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 3,191E-06 1,79E-04 ! regulation of homeostatic process GO:0032844 105 60 5,000 3,25E-06 1,78E-04 ! regulation of glucose metabolic process GO:0010906 22 16 3,000 3,487E-06 1,865E-04 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 3,000 3,487E-06 1,823E-04 ! respiratory tube development GO:0030323 99 62 5,000 3,947E-06 2,017E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 5,000 4,339E-06 2,169E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 4,536E-06 2,22E-04 ! respiratory system development GO:0060541 100 64 5,000 4,761E-06 2,281E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 5,801E-06 2,723E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 6,06E-06 2,787E-04 ! N-terminal protein amino acid acetylation GO:0006474 7 6 2,000 6,06E-06 2,733E-04 ! ER overload response GO:0006983 7 6 2,000 6,06E-06 2,68E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 2,000 6,06E-06 2,63E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 6,06E-06 2,581E-04 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 7,305E-06 3,055E-04 ! regulation of carbohydrate metabolic process GO:0006109 28 19 3,000 7,31E-06 3,002E-04 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 9,089E-06 3,668E-04 ! positive regulation of locomotion GO:0040017 35 20 3,000 9,089E-06 3,604E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 3,000 9,089E-06 3,543E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 1,051E-05 4,03E-04 ! regulation of gene-specific transcription GO:0032583 69 43 4,000 1,051E-05 3,964E-04 ! response to insulin stimulus GO:0032868 63 43 4,000 1,051E-05 3,9E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,055E-05 3,852E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,055E-05 3,792E-04 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 1,055E-05 3,734E-04 ! positive regulation of monooxygenase activity GO:0032770 11 7 2,000 1,055E-05 3,677E-04 ! regulation of chemotaxis GO:0050920 36 21 3,000 1,117E-05 3,834E-04 ! regulation of mast cell proliferation GO:0070666 64 44 4,000 1,18E-05 3,99E-04 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 1,32E-05 4,4E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 1,358E-05 4,462E-04 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 1,358E-05 4,399E-04 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 38 22 3,000 1,358E-05 4,338E-04 ! protein tetramerization GO:0051262 39 22 3,000 1,358E-05 4,278E-04 ! regulation of leukocyte proliferation GO:0070663 71 47 4,000 1,639E-05 5,095E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 1,68E-05 5,152E-04 ! positive regulation of B cell proliferation GO:0030890 11 8 2,000 1,68E-05 5,084E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 1,68E-05 5,018E-04 ! positive regulation of endothelial cell migration GO:0010595 18 8 2,000 1,68E-05 4,953E-04 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 1,68E-05 4,891E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,68E-05 4,83E-04 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 1,68E-05 4,77E-04 ! regulation of endothelial cell proliferation GO:0001936 46 24 3,000 1,952E-05 5,475E-04 ! glutathione metabolic process GO:0006749 29 24 3,000 1,952E-05 5,409E-04 ! cartilage development GO:0051216 70 49 4,000 2,016E-05 5,52E-04 ! motor axon guidance GO:0008045 14 9 2,000 2,507E-05 6,784E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,507E-05 6,706E-04 ! regulation of hormone metabolic process GO:0032350 15 9 2,000 2,507E-05 6,628E-04 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 2,000 2,507E-05 6,553E-04 ! regulation of RNA splicing GO:0043484 14 9 2,000 2,507E-05 6,479E-04 ! embryonic placenta development GO:0001892 12 9 2,000 2,507E-05 6,407E-04 ! cell cycle arrest GO:0007050 150 86 5,000 2,644E-05 6,681E-04 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 3,000 2,717E-05 6,794E-04 ! negative regulation of protein modification process GO:0031400 50 26 3,000 2,717E-05 6,721E-04 ! blood vessel remodeling GO:0001974 21 10 2,000 3,564E-05 8,72E-04 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 3,564E-05 8,629E-04 ! response to X-ray GO:0010165 16 10 2,000 3,564E-05 8,539E-04 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 2,000 3,564E-05 8,451E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 3,564E-05 8,365E-04 ! placenta development GO:0001890 37 28 3,000 3,683E-05 8,556E-04 ! regulation of B cell activation GO:0050864 42 28 3,000 3,683E-05 8,471E-04 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 4,123E-05 9,39E-04 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 4,239E-05 9,558E-04 ! angiogenesis GO:0001525 149 95 5,000 4,65E-05 1,038E-03 ! regulation of mRNA processing GO:0050684 18 11 2,000 4,876E-05 1,078E-03 ! focal adhesion formation GO:0048041 24 11 2,000 4,876E-05 1,068E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 4,876E-05 1,058E-03 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 2,000 4,876E-05 1,048E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 4,876E-05 1,038E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 4,876E-05 1,029E-03 GO:0042130|negative regulation of T cell proliferation, ! spliceosome assembly GO:0000245 49 30 3,000 4,878E-05 1,02E-03 ! response to light stimulus GO:0009416 153 96 5,000 4,932E-05 1,022E-03 ! positive regulation of gene-specific transcription GO:0043193 47 31 3,000 5,571E-05 1,144E-03 ! auditory receptor cell differentiation GO:0042491 25 12 2,000 6,469E-05 1,317E-03 ! histone acetylation GO:0016573 23 12 2,000 6,469E-05 1,305E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 6,469E-05 1,294E-03 ! response to gamma radiation GO:0010332 20 12 2,000 6,469E-05 1,283E-03 ! regulation of transcription factor activity GO:0051090 97 63 4,000 6,888E-05 1,354E-03 GO:0090046|regulation of transcription regulator activity, ! negative regulation of cell adhesion GO:0007162 67 33 3,000 7,169E-05 1,397E-03 ! carbohydrate homeostasis GO:0033500 39 33 3,000 7,169E-05 1,386E-03 GO:0042593|glucose homeostasis, ! negative regulation of cell size GO:0045792 108 64 4,000 7,431E-05 1,424E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 8,368E-05 1,591E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 9,078E-05 1,711E-03 ! tissue remodeling GO:0048771 62 36 3,000 1,016E-04 1,9E-03 ! regulation of S phase GO:0033261 18 14 2,000 1,06E-04 1,966E-03 ! inositol metabolic process GO:0006020 20 14 2,000 1,06E-04 1,95E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 1,06E-04 1,935E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 1,142E-04 2,068E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 4,000 1,222E-04 2,195E-03 ! regulation of T cell proliferation GO:0042129 58 38 3,000 1,26E-04 2,246E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 1,306E-04 2,31E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 4,000 1,306E-04 2,293E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,318E-04 2,297E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,318E-04 2,28E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,318E-04 2,262E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of transport GO:0051051 116 73 4,000 1,394E-04 2,376E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,396E-04 2,362E-03 ! response to oxygen levels GO:0070482 137 74 4,000 1,487E-04 2,497E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 1,487E-04 2,479E-03 ! peptide metabolic process GO:0006518 56 40 3,000 1,543E-04 2,554E-03 ! T cell differentiation GO:0030217 65 40 3,000 1,543E-04 2,536E-03 ! positive regulation of protein transport GO:0051222 55 40 3,000 1,543E-04 2,518E-03 ! negative regulation of growth GO:0045926 123 75 4,000 1,585E-04 2,567E-03 ! regulation of ligase activity GO:0051340 114 75 4,000 1,585E-04 2,549E-03 ! endothelial cell migration GO:0043542 22 16 2,000 1,614E-04 2,578E-03 ! protein amino acid acetylation GO:0006473 28 16 2,000 1,614E-04 2,561E-03 ! neural crest cell migration GO:0001755 24 16 2,000 1,614E-04 2,543E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,614E-04 2,526E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 1,614E-04 2,509E-03 ! regulation of protein transport GO:0051223 114 76 4,000 1,687E-04 2,605E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of T cell differentiation GO:0045580 59 41 3,000 1,701E-04 2,609E-03 ! regulation of DNA binding GO:0051101 119 77 4,000 1,795E-04 2,734E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 1,871E-04 2,831E-03 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 2,000 1,95E-04 2,932E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 1,95E-04 2,913E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,95E-04 2,894E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 1,95E-04 2,876E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,95E-04 2,857E-03 ! regulation of immunoglobulin production GO:0002637 25 17 2,000 1,95E-04 2,839E-03 ! ribonucleoprotein complex assembly GO:0022618 70 44 3,000 2,245E-04 3,248E-03 ! regulation of inflammatory response GO:0050727 60 44 3,000 2,245E-04 3,227E-03 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 2,329E-04 3,327E-03 ! regulation of glucose import GO:0046324 21 18 2,000 2,329E-04 3,307E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 2,329E-04 3,286E-03 ! ossification GO:0001503 134 82 4,000 2,413E-04 3,384E-03 GO:0060348|bone development, ! positive regulation of cell cycle GO:0045787 77 45 3,000 2,451E-04 3,417E-03 ! positive regulation of defense response GO:0031349 59 45 3,000 2,451E-04 3,396E-03 ! regulation of cell adhesion GO:0030155 159 83 4,000 2,554E-04 3,517E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 2,752E-04 3,768E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 2,752E-04 3,745E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 2,752E-04 3,723E-03 ! regulation of endothelial cell migration GO:0010594 40 19 2,000 2,752E-04 3,701E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 2,752E-04 3,68E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 2,752E-04 3,659E-03 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 2,854E-04 3,772E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 2,854E-04 3,751E-03 ! regulation of protein localization GO:0032880 132 85 4,000 2,854E-04 3,729E-03 ! negative regulation of immune system process GO:0002683 73 47 3,000 2,904E-04 3,773E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 3,014E-04 3,894E-03 ! heart morphogenesis GO:0003007 65 48 3,000 3,151E-04 4,049E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 3,151E-04 4,027E-03 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 3,151E-04 4,004E-03 ! positive regulation of cytokine production GO:0001819 73 48 3,000 3,151E-04 3,982E-03 ! positive regulation of B cell activation GO:0050871 31 20 2,000 3,222E-04 4,049E-03 ! interphase GO:0051325 159 88 4,000 3,354E-04 4,192E-03 ! sulfur compound biosynthetic process GO:0044272 62 49 3,000 3,413E-04 4,244E-03 ! regulation of intracellular transport GO:0032386 78 49 3,000 3,413E-04 4,221E-03 ! lipid modification GO:0030258 73 50 3,000 3,691E-04 4,54E-03 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 3,000 3,691E-04 4,516E-03 ! protein amino acid acylation GO:0043543 37 21 2,000 3,74E-04 4,551E-03 ! cell aging GO:0007569 32 21 2,000 3,74E-04 4,527E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 3,74E-04 4,504E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 3,74E-04 4,48E-03 ! activation of phospholipase C activity GO:0007202 87 51 3,000 3,984E-04 4,748E-03 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 3,000 3,984E-04 4,723E-03 ! negative regulation of cell motion GO:0051271 104 51 3,000 3,984E-04 4,699E-03 ! positive regulation of phospholipase activity GO:0010518 88 52 3,000 4,294E-04 5,038E-03 ! aging GO:0007568 79 52 3,000 4,294E-04 5,013E-03 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 4,309E-04 5,005E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 4,309E-04 4,98E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,534E-04 5,214E-03 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 1,000 4,534E-04 5,188E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 4,534E-04 5,162E-03 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 4,534E-04 5,137E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 4,534E-04 5,111E-03 ! anagen GO:0042640 6 5 1,000 4,534E-04 5,087E-03 ! microvillus organization GO:0032528 7 5 1,000 4,534E-04 5,062E-03 GO:0030033|microvillus assembly, ! response to food GO:0032094 5 5 1,000 4,534E-04 5,037E-03 ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 1,000 4,534E-04 5,013E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 4,534E-04 4,989E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 4,534E-04 4,965E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 4,534E-04 4,942E-03 ! centrosome duplication GO:0051298 5 5 1,000 4,534E-04 4,919E-03 ! response to UV-C GO:0010225 6 5 1,000 4,534E-04 4,895E-03 ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 4,534E-04 4,873E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! positive regulation of chemokine production GO:0032722 7 5 1,000 4,534E-04 4,85E-03 ! enteric nervous system development GO:0048484 8 5 1,000 4,534E-04 4,827E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 4,534E-04 4,805E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 4,534E-04 4,783E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 1,000 4,534E-04 4,761E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 4,534E-04 4,74E-03 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 4,534E-04 4,718E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! regulation of binding GO:0051098 151 95 4,000 4,776E-04 4,948E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 4,931E-04 5,086E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 4,931E-04 5,063E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 4,931E-04 5,04E-03 ! cellular response to oxidative stress GO:0034599 33 23 2,000 4,931E-04 5,018E-03 ! regulation of phospholipase activity GO:0010517 90 54 3,000 4,963E-04 5,029E-03 ! positive regulation of lipase activity GO:0060193 90 54 3,000 4,963E-04 5,007E-03 ! regulation of response to external stimulus GO:0032101 139 96 4,000 5,012E-04 5,033E-03 ! in utero embryonic development GO:0001701 147 96 4,000 5,012E-04 5,012E-03 ! neural crest cell development GO:0014032 39 24 2,000 5,607E-04 5,583E-03 GO:0014033|neural crest cell differentiation, ! negative regulation of response to stimulus GO:0048585 80 56 3,000 5,705E-04 5,655E-03 ! coenzyme biosynthetic process GO:0009108 67 57 3,000 6,103E-04 6,025E-03 ! developmental maturation GO:0021700 75 57 3,000 6,103E-04 5,999E-03 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 6,34E-04 6,205E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 6,77E-04 6,598E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 6,77E-04 6,57E-03 ! male meiosis GO:0007140 7 6 1,000 6,77E-04 6,543E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 6,77E-04 6,515E-03 ! mRNA stabilization GO:0048255 15 6 1,000 6,77E-04 6,488E-03 GO:0043489|RNA stabilization, ! cGMP-mediated signaling GO:0019934 10 6 1,000 6,77E-04 6,461E-03 ! activation of MAPKKK activity GO:0000185 10 6 1,000 6,77E-04 6,434E-03 ! thymic T cell selection GO:0045061 12 6 1,000 6,77E-04 6,408E-03 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 1,000 6,77E-04 6,382E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 6,77E-04 6,356E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 6,77E-04 6,33E-03 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 6,77E-04 6,304E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 6,77E-04 6,279E-03 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 6,77E-04 6,254E-03 ! male sex determination GO:0030238 9 6 1,000 6,77E-04 6,229E-03 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 6,77E-04 6,204E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 6,77E-04 6,179E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 1,000 6,77E-04 6,155E-03 ! gas homeostasis GO:0033483 11 6 1,000 6,77E-04 6,13E-03 ! hair follicle maturation GO:0048820 7 6 1,000 6,77E-04 6,106E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 6,77E-04 6,083E-03 ! blastocyst growth GO:0001832 15 6 1,000 6,77E-04 6,059E-03 ! negative regulation of B cell activation GO:0050869 9 6 1,000 6,77E-04 6,035E-03 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 7,132E-04 6,333E-03 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 7,417E-04 6,561E-03 ! cell-matrix adhesion GO:0007160 114 61 3,000 7,896E-04 6,958E-03 ! urogenital system development GO:0001655 101 61 3,000 7,896E-04 6,932E-03 ! negative regulation of ligase activity GO:0051352 91 61 3,000 7,896E-04 6,905E-03 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 3,000 7,896E-04 6,879E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 7,984E-04 6,929E-03 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 2,000 7,984E-04 6,903E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 7,984E-04 6,877E-03 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 7,984E-04 6,852E-03 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 2,000 7,984E-04 6,826E-03 ! negative regulation of cell growth GO:0030308 106 62 3,000 8,397E-04 7,153E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 3,000 8,397E-04 7,126E-03 ! cell junction assembly GO:0034329 56 28 2,000 8,898E-04 7,524E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 8,898E-04 7,496E-03 ! regulation of lipase activity GO:0060191 109 63 3,000 8,919E-04 7,487E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 9,436E-04 7,892E-03 ! positive regulation of isotype switching GO:0045830 15 7 1,000 9,436E-04 7,863E-03 GO:0045911|positive regulation of DNA recombination, ! hemoglobin metabolic process GO:0020027 10 7 1,000 9,436E-04 7,835E-03 ! retinol metabolic process GO:0042572 9 7 1,000 9,436E-04 7,807E-03 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 9,436E-04 7,779E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 9,436E-04 7,751E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 9,436E-04 7,723E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 9,436E-04 7,696E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 9,436E-04 7,669E-03 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 9,436E-04 7,642E-03 GO:0002714|positive regulation of B cell mediated immunity, ! response to tumor cell GO:0002347 12 7 1,000 9,436E-04 7,615E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 9,436E-04 7,588E-03 ! muscle adaptation GO:0043500 12 7 1,000 9,436E-04 7,562E-03 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 9,436E-04 7,536E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 9,436E-04 7,51E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 9,464E-04 7,506E-03 ! tissue homeostasis GO:0001894 42 29 2,000 9,875E-04 7,805E-03 GO:0048871|multicellular organismal homeostasis, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 3,000 1,003E-03 7,902E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 3,000 1,003E-03 7,875E-03 ! protein oligomerization GO:0051259 100 65 3,000 1,003E-03 7,849E-03 ! cell-substrate adhesion GO:0031589 121 66 3,000 1,062E-03 8,283E-03 ! embryonic epithelial tube formation GO:0001838 44 30 2,000 1,092E-03 8,484E-03 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,092E-03 8,455E-03 ! learning or memory GO:0007611 123 68 3,000 1,188E-03 9,169E-03 ! mammary gland development GO:0030879 57 31 2,000 1,203E-03 9,253E-03 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,203E-03 9,222E-03 GO:0060326|cell chemotaxis, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,253E-03 9,571E-03 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 1,253E-03 9,539E-03 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 1,000 1,253E-03 9,508E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,253E-03 9,476E-03 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 1,000 1,253E-03 9,445E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 1,253E-03 9,415E-03 ! positive regulation of ligase activity GO:0051351 99 69 3,000 1,255E-03 9,399E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 1,321E-03 9,863E-03 ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 1,395E-03 0,01038661 ! lymphocyte differentiation GO:0030098 113 71 3,000 1,395E-03 0,0103531 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,446E-03 0,01069109 ! cell junction organization GO:0034330 63 33 2,000 1,446E-03 0,01065682 ! negative regulation of DNA binding GO:0043392 54 33 2,000 1,446E-03 0,01062278 ! mitochondrion organization GO:0007005 104 73 3,000 1,547E-03 0,01133111 ! polyol metabolic process GO:0019751 44 34 2,000 1,578E-03 0,0115197 ! embryonic organ development GO:0048568 45 34 2,000 1,578E-03 0,01148325 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 1,603E-03 0,01163236 ! regulation of developmental growth GO:0048638 13 9 1,000 1,603E-03 0,01159578 ! lung alveolus development GO:0048286 17 9 1,000 1,603E-03 0,01155943 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,603E-03 0,01152331 ! T cell selection GO:0045058 18 9 1,000 1,603E-03 0,01148741 ! L-serine metabolic process GO:0006563 13 9 1,000 1,603E-03 0,01145174 ! receptor clustering GO:0043113 15 9 1,000 1,603E-03 0,01141628 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,603E-03 0,01138105 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 1,603E-03 0,01134603 GO:0002820|negative regulation of adaptive immune response, ! oocyte differentiation GO:0009994 12 9 1,000 1,603E-03 0,01131123 GO:0048599|oocyte development, ! regulation of muscle adaptation GO:0043502 12 9 1,000 1,603E-03 0,01127663 ! localization within membrane GO:0051668 15 9 1,000 1,603E-03 0,01124225 ! cofactor biosynthetic process GO:0051188 92 75 3,000 1,71E-03 0,01195136 ! glycogen metabolic process GO:0005977 48 35 2,000 1,717E-03 0,01196764 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 1,717E-03 0,01193149 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 1,864E-03 0,01291298 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 2,000 1,864E-03 0,0128742 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 1,864E-03 0,01283566 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 2,000 1,864E-03 0,01279734 GO:0006073|cellular glucan metabolic process, ! positive regulation of protein modification process GO:0031401 107 78 3,000 1,975E-03 0,01352075 ! negative regulation of muscle development GO:0048635 12 10 1,000 1,995E-03 0,01361671 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 1,995E-03 0,01357642 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,995E-03 0,01353638 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 1,995E-03 0,01349656 ! glucan biosynthetic process GO:0009250 13 10 1,000 1,995E-03 0,01345698 GO:0005978|glycogen biosynthetic process, ! regulation of bone resorption GO:0045124 24 10 1,000 1,995E-03 0,01341764 ! regulation of B cell differentiation GO:0045577 16 10 1,000 1,995E-03 0,01337852 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,995E-03 0,01333963 ! nitric oxide mediated signal transduction GO:0007263 17 10 1,000 1,995E-03 0,01330096 ! T cell receptor signaling pathway GO:0050852 18 10 1,000 1,995E-03 0,01326252 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 1,995E-03 0,0132243 ! negative regulation of immune effector process GO:0002698 16 10 1,000 1,995E-03 0,0131863 ! learning GO:0007612 67 37 2,000 2,018E-03 0,01330197 ! T cell activation GO:0042110 134 79 3,000 2,07E-03 0,0136012 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 3,000 2,167E-03 0,01420215 GO:0010498|proteasomal protein catabolic process, ! mesenchymal cell development GO:0014031 64 38 2,000 2,181E-03 0,0142485 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of cell cycle process GO:0010564 122 81 3,000 2,268E-03 0,01477818 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 2,000 2,351E-03 0,01527306 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 2,351E-03 0,01523004 ! developmental growth GO:0048589 62 39 2,000 2,351E-03 0,01518725 ! virus-host interaction GO:0019048 17 11 1,000 2,428E-03 0,01564047 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 2,428E-03 0,01559678 GO:0000725|recombinational repair, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 2,428E-03 0,01555334 ! T cell proliferation GO:0042098 20 11 1,000 2,428E-03 0,01551014 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,428E-03 0,01546717 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 2,428E-03 0,01542444 ! protein homotetramerization GO:0051289 18 11 1,000 2,428E-03 0,01538195 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 2,428E-03 0,01533969 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 2,428E-03 0,01529767 ! T cell homeostasis GO:0043029 20 11 1,000 2,428E-03 0,01525587 ! regulation of isotype switching GO:0045191 19 11 1,000 2,428E-03 0,0152143 ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,428E-03 0,01517296 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 2,428E-03 0,01513184 ! inner ear development GO:0048839 57 40 2,000 2,529E-03 0,01571961 ! double-strand break repair GO:0006302 67 40 2,000 2,529E-03 0,01567724 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 2,529E-03 0,0156351 ! regulation of defense response GO:0031347 117 84 3,000 2,59E-03 0,0159687 ! Golgi vesicle transport GO:0048193 138 85 3,000 2,703E-03 0,0166258 ! energy reserve metabolic process GO:0006112 59 41 2,000 2,715E-03 0,01665211 ! positive regulation of DNA binding GO:0043388 57 41 2,000 2,715E-03 0,01660782 ! cartilage condensation GO:0001502 18 12 1,000 2,9E-03 0,01769395 ! heart looping GO:0001947 15 12 1,000 2,9E-03 0,01764714 ! autonomic nervous system development GO:0048483 23 12 1,000 2,9E-03 0,01760058 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,9E-03 0,01755426 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,9E-03 0,01750819 ! microspike assembly GO:0030035 23 12 1,000 2,9E-03 0,01746236 ! anatomical structure homeostasis GO:0060249 136 88 3,000 3,065E-03 0,01840828 ! positive regulation of binding GO:0051099 59 43 2,000 3,112E-03 0,01864137 ! leukocyte migration GO:0050900 60 43 2,000 3,112E-03 0,01859296 ! activation of caspase activity GO:0006919 65 43 2,000 3,112E-03 0,01854479 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 3,112E-03 0,01849687 ! reproductive developmental process GO:0003006 127 89 3,000 3,193E-03 0,01892758 ! regulation of T cell activation GO:0050863 128 89 3,000 3,193E-03 0,01887892 ! negative regulation of cell migration GO:0030336 92 44 2,000 3,324E-03 0,01960072 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 3,324E-03 0,01955059 ! leukocyte differentiation GO:0002521 143 90 3,000 3,324E-03 0,01950424 ! regulation of chemokine production GO:0032642 17 13 1,000 3,412E-03 0,01997065 ! bone mineralization GO:0030282 15 13 1,000 3,412E-03 0,01991996 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 3,412E-03 0,01986953 ! genitalia development GO:0048806 15 13 1,000 3,412E-03 0,01981936 ! regulation of cellular pH GO:0030641 20 13 1,000 3,412E-03 0,01976943 ! regulation of RNA stability GO:0043487 28 13 1,000 3,412E-03 0,01971976 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,412E-03 0,01967034 ! vascular process in circulatory system GO:0003018 69 45 2,000 3,543E-03 0,02037508 ! cell maturation GO:0048469 60 45 2,000 3,543E-03 0,02032427 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 3,598E-03 0,02058288 ! sulfur metabolic process GO:0006790 118 92 3,000 3,598E-03 0,0205318 ! histone modification GO:0016570 68 46 2,000 3,772E-03 0,02147471 ! neuron maturation GO:0042551 21 14 1,000 3,963E-03 0,02250844 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,963E-03 0,022453 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 3,963E-03 0,02239783 ! retina development in camera-type eye GO:0060041 18 14 1,000 3,963E-03 0,02234293 ! activation of MAPKK activity GO:0000186 21 14 1,000 3,963E-03 0,02228831 ! cellular response to starvation GO:0009267 21 14 1,000 3,963E-03 0,02223394 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 3,963E-03 0,02217985 ! G1/S transition checkpoint GO:0031575 33 14 1,000 3,963E-03 0,02212601 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,963E-03 0,02207244 ! mRNA splice site selection GO:0006376 26 14 1,000 3,963E-03 0,02201912 ! muscle maintenance GO:0046716 19 14 1,000 3,963E-03 0,02196607 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 3,963E-03 0,02191326 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 3,963E-03 0,02186071 ! covalent chromatin modification GO:0016569 75 47 2,000 4,009E-03 0,02206166 ! regulation of cellular component biogenesis GO:0044087 158 96 3,000 4,189E-03 0,02299573 ! positive regulation of caspase activity GO:0043280 72 48 2,000 4,256E-03 0,02330534 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 4,256E-03 0,02324998 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 4,256E-03 0,02319488 ! regulation of angiogenesis GO:0045765 94 49 2,000 4,511E-03 0,02452814 ! germ cell development GO:0007281 68 49 2,000 4,511E-03 0,02447029 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 4,553E-03 0,02463935 ! lipid phosphorylation GO:0046834 23 15 1,000 4,553E-03 0,02458151 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 4,553E-03 0,02452394 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 4,553E-03 0,02446665 ! centrosome cycle GO:0007098 16 15 1,000 4,553E-03 0,02440961 ! positive regulation of proteolysis GO:0045862 19 15 1,000 4,553E-03 0,02435285 ! regulation of survival gene product expression GO:0045884 20 15 1,000 4,553E-03 0,02429634 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 4,553E-03 0,0242401 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 4,553E-03 0,02418412 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 4,553E-03 0,0241284 ! biomineral formation GO:0031214 18 15 1,000 4,553E-03 0,02407293 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 4,553E-03 0,02401772 ! defense response to virus GO:0051607 27 15 1,000 4,553E-03 0,02396276 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 4,674E-03 0,0245431 ! ear development GO:0043583 72 50 2,000 4,775E-03 0,02501931 ! positive regulation of growth GO:0045927 67 50 2,000 4,775E-03 0,02496244 ! negative regulation of immune response GO:0050777 28 16 1,000 5,18E-03 0,02701733 ! oogenesis GO:0048477 23 16 1,000 5,18E-03 0,02695621 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 1,000 5,18E-03 0,02689536 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 5,18E-03 0,02683478 ! nucleotide-excision repair GO:0006289 64 52 2,000 5,332E-03 0,02755773 ! kidney development GO:0001822 90 53 2,000 5,624E-03 0,02900275 ! cell projection assembly GO:0030031 76 53 2,000 5,624E-03 0,02893786 ! positive regulation of cell killing GO:0031343 24 17 1,000 5,845E-03 0,0300077 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 5,845E-03 0,02994086 ! signal complex assembly GO:0007172 29 17 1,000 5,845E-03 0,02987433 ! forelimb morphogenesis GO:0035136 19 17 1,000 5,845E-03 0,02980809 ! retinoid metabolic process GO:0001523 22 17 1,000 5,845E-03 0,02974214 GO:0016101|diterpenoid metabolic process, ! actin filament bundle formation GO:0051017 26 17 1,000 5,845E-03 0,02967649 ! neuromuscular junction development GO:0007528 23 17 1,000 5,845E-03 0,02961112 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 5,845E-03 0,02954604 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 5,845E-03 0,02948125 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of intracellular transport GO:0032387 29 17 1,000 5,845E-03 0,02941674 ! vitamin A metabolic process GO:0006776 22 17 1,000 5,845E-03 0,02935251 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 5,845E-03 0,02928856 ! positive regulation of DNA replication GO:0045740 29 18 1,000 6,546E-03 0,03273244 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 6,546E-03 0,03266143 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 6,546E-03 0,03259074 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 6,546E-03 0,03252035 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 6,546E-03 0,03245026 GO:0050886|endocrine process, ! response to retinoic acid GO:0032526 25 18 1,000 6,546E-03 0,03238047 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 6,546E-03 0,03231099 ! somitogenesis GO:0001756 24 18 1,000 6,546E-03 0,0322418 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 6,546E-03 0,03217291 ! cellular response to nutrient levels GO:0031669 27 18 1,000 6,546E-03 0,03210431 ! vitamin transport GO:0051180 24 18 1,000 6,546E-03 0,032036 ! terpenoid metabolic process GO:0006721 24 18 1,000 6,546E-03 0,03196798 ! gut development GO:0048565 26 18 1,000 6,546E-03 0,03190026 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 6,546E-03 0,03183281 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 6,558E-03 0,03181917 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 7,284E-03 0,03527128 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 7,284E-03 0,03519718 ! digestive system process GO:0022600 30 19 1,000 7,284E-03 0,03512339 ! response to vitamin A GO:0033189 26 19 1,000 7,284E-03 0,03504991 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 7,284E-03 0,03497674 ! apoptotic nuclear changes GO:0030262 24 19 1,000 7,284E-03 0,03490387 ! response to starvation GO:0042594 30 19 1,000 7,284E-03 0,03483131 ! sex determination GO:0007530 29 19 1,000 7,284E-03 0,03475904 ! renal system process GO:0003014 35 19 1,000 7,284E-03 0,03468708 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 7,284E-03 0,03461541 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 7,284E-03 0,03454404 ! protein stabilization GO:0050821 26 19 1,000 7,284E-03 0,03447296 ! activation of MAPK activity GO:0000187 84 59 2,000 7,578E-03 0,03578928 ! actin filament organization GO:0007015 95 59 2,000 7,578E-03 0,03571594 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 2,000 7,938E-03 0,03733523 ! regulation of heart contraction GO:0008016 91 60 2,000 7,938E-03 0,03725904 ! response to vitamin GO:0033273 29 20 1,000 8,058E-03 0,03774556 ! hindlimb morphogenesis GO:0035137 32 20 1,000 8,058E-03 0,03766884 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 8,058E-03 0,03759243 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 8,058E-03 0,03751633 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 8,058E-03 0,03744054 ! regulation of cell killing GO:0031341 34 21 1,000 8,867E-03 0,04111567 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 8,867E-03 0,04103295 ! gluconeogenesis GO:0006094 25 21 1,000 8,867E-03 0,04095055 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 8,867E-03 0,04086849 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 8,867E-03 0,04078675 ! regulation of DNA recombination GO:0000018 40 21 1,000 8,867E-03 0,04070534 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 8,867E-03 0,04062425 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 8,867E-03 0,04054349 ! regulation of insulin secretion GO:0050796 26 21 1,000 8,867E-03 0,04046304 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 8,867E-03 0,04038292 ! regulation of vasoconstriction GO:0019229 31 21 1,000 8,867E-03 0,04030311 ! immunoglobulin production GO:0002377 33 21 1,000 8,867E-03 0,04022362 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 26 21 1,000 8,867E-03 0,04014444 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 8,867E-03 0,04006557 ! cell cycle checkpoint GO:0000075 108 64 2,000 9,477E-03 0,04273888 ! spliceosomal snRNP biogenesis GO:0000387 28 22 1,000 9,71E-03 0,04370569 ! leukocyte adhesion GO:0007159 38 22 1,000 9,71E-03 0,04362032 ! molting cycle process GO:0022404 40 22 1,000 9,71E-03 0,04353529 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 1,000 9,71E-03 0,0434506 ! vasculogenesis GO:0001570 33 22 1,000 9,71E-03 0,04336623 ! microtubule organizing center organization GO:0031023 28 22 1,000 9,71E-03 0,04328218 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 9,71E-03 0,04319846 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! ureteric bud development GO:0001657 32 22 1,000 9,71E-03 0,04311507 ! leukocyte homeostasis GO:0001776 33 22 1,000 9,71E-03 0,043032 ! blastocyst development GO:0001824 37 22 1,000 9,71E-03 0,04294924 ! neural tube closure GO:0001843 33 22 1,000 9,71E-03 0,04286681 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! reproductive structure development GO:0048608 90 65 2,000 9,887E-03 0,04356295 ! regulation of caspase activity GO:0043281 97 65 2,000 9,887E-03 0,04347966 ! axon guidance GO:0007411 99 66 2,000 0,01030711 0,04524113 ! regulation of immune effector process GO:0002697 101 66 2,000 0,01030711 0,04515495 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01058809 0,04629774 ! myelination GO:0042552 35 23 1,000 0,01058809 0,04620988 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01058809 0,04612237 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01058809 0,04603518 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01058809 0,04594832 ! interaction with host GO:0051701 37 23 1,000 0,01058809 0,04586179 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01058809 0,04577558 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,01058809 0,0456897 ! fat-soluble vitamin metabolic process GO:0006775 28 23 1,000 0,01058809 0,04560414 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01058809 0,0455189 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01073757 0,04607538 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01117832 0,04787733 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,01149967 0,04916216 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01149967 0,04907095 ! receptor metabolic process GO:0043112 37 24 1,000 0,01149967 0,04898007 ! primary neural tube formation GO:0014020 35 24 1,000 0,01149967 0,04888954 ! negative regulation of cell development GO:0010721 56 24 1,000 0,01149967 0,04879934 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,01149967 0,04870947 ! base-excision repair GO:0006284 31 24 1,000 0,01149967 0,04861993 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,01149967 0,04853072 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01149967 0,04844183 ! protein amino acid alkylation GO:0008213 39 25 1,000 0,01244451 0,05232608 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,01244451 0,0522306 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01244451 0,05213546 ! regulation of peptide secretion GO:0002791 34 25 1,000 0,01244451 0,05204067 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01244451 0,05194622 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01244451 0,05185211 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01244451 0,05175835 GO:0032943|mononuclear cell proliferation, ! regulation of peptidase activity GO:0052547 106 72 2,000 0,013045 0,05415795 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01342212 0,05562319 ! regulation of pH GO:0006885 36 26 1,000 0,01342212 0,05552314 ! tube morphogenesis GO:0035239 118 73 2,000 0,01353778 0,05590105 ! protein import into nucleus GO:0006606 118 74 2,000 0,01404105 0,05787531 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,01404105 0,05777178 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 0,01443202 0,05927435 ! response to nutrient GO:0007584 104 75 2,000 0,01455487 0,05967236 ! nuclear import GO:0051170 121 75 2,000 0,01455487 0,05956618 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,01547373 0,06321416 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01547373 0,06310208 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,01547373 0,0629904 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,01547373 0,06287911 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01547373 0,06276821 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01547373 0,0626577 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01547373 0,06254758 ! gland development GO:0048732 148 77 2,000 0,01561419 0,06300463 ! sex differentiation GO:0007548 105 77 2,000 0,01561419 0,06289429 ! protein ubiquitination GO:0016567 125 77 2,000 0,01561419 0,06278434 ! carbohydrate biosynthetic process GO:0016051 97 77 2,000 0,01561419 0,06267477 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,01654678 0,06630243 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01654678 0,06618712 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,01654678 0,06607221 ! eye morphogenesis GO:0048592 51 29 1,000 0,01654678 0,0659577 ! protein localization in nucleus GO:0034504 133 80 2,000 0,01728276 0,06877224 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,01765071 0,07011506 ! collagen metabolic process GO:0032963 40 30 1,000 0,01765071 0,06999418 ! response to heat GO:0009408 41 30 1,000 0,01765071 0,06987371 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,01765071 0,06975365 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,01786025 0,07046067 GO:0002696|positive regulation of leukocyte activation, ! DNA damage checkpoint GO:0000077 53 31 1,000 0,01878504 0,07398218 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,01878504 0,07385572 ! segmentation GO:0035282 41 31 1,000 0,01878504 0,07372968 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01878504 0,07360408 ! metanephros development GO:0001656 58 31 1,000 0,01878504 0,0734789 ! regulation of muscle development GO:0048634 48 32 1,000 0,01994933 0,07790061 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,01994933 0,07776857 ! regulation of ARF protein signal transduction GO:0032012 51 32 1,000 0,01994933 0,07763698 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01994933 0,07750584 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01994933 0,07737514 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01994933 0,07724488 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,01994933 0,07711505 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,01994933 0,07698567 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01994933 0,07685671 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,02027703 0,07798858 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,02027703 0,07785839 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02114312 0,08104861 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! nucleus organization GO:0006997 49 33 1,000 0,02114312 0,08091376 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02114312 0,08077935 ! female gonad development GO:0008585 49 33 1,000 0,02114312 0,08064539 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02114312 0,08051187 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02114312 0,08037879 ! cytokinesis GO:0000910 52 33 1,000 0,02114312 0,08024615 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02154965 0,08165437 GO:0060538|skeletal muscle organ development, ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02236596 0,08460806 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02236596 0,08446913 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02236596 0,08433065 ! neuron migration GO:0001764 46 34 1,000 0,02236596 0,08419263 ! female gamete generation GO:0007292 43 34 1,000 0,02236596 0,08405506 ! isoprenoid metabolic process GO:0006720 46 34 1,000 0,02236596 0,08391794 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,02353897 0,0881753 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,0236174 0,08832524 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,0236174 0,08818186 ! maintenance of protein location GO:0045185 65 35 1,000 0,0236174 0,08803894 ! protein homooligomerization GO:0051260 52 35 1,000 0,0236174 0,08789648 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,02489702 0,0925091 ! neural tube development GO:0021915 50 36 1,000 0,02489702 0,0923599 ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,02489702 0,09221117 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 2,000 0,02491877 0,09214337 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,02562474 0,09460176 ! regulation of protein secretion GO:0050708 51 37 1,000 0,02620436 0,0965866 ! response to oxidative stress GO:0006979 141 94 2,000 0,02634141 0,09693638 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,02753901 0,10118168 ! maintenance of location in cell GO:0051651 69 38 1,000 0,02753901 0,10102031 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,02780682 0,10184028 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,02890054 0,10567766 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,02890054 0,10550992 ! chromatin remodeling GO:0006338 68 39 1,000 0,02890054 0,10534271 ! synapse organization GO:0050808 55 39 1,000 0,02890054 0,10517603 ! protein import GO:0017038 156 99 2,000 0,03008497 0,10931347 ! regulation of tube size GO:0035150 60 40 1,000 0,03028853 0,10987953 GO:0050880|regulation of blood vessel size, ! B cell differentiation GO:0030183 62 40 1,000 0,03028853 0,10970649 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,03086563 0,111621 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 2,000 0,03086563 0,11144577 ! protein localization in organelle GO:0033365 161 100 2,000 0,03086563 0,11127109 ! glucose transport GO:0015758 52 41 1,000 0,03170256 0,11410936 ! endosome transport GO:0016197 71 41 1,000 0,03170256 0,11393106 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,03170256 0,11375332 ! biopolymer methylation GO:0043414 62 41 1,000 0,03170256 0,11357614 ! mitochondrial transport GO:0006839 60 42 1,000 0,03314221 0,11854912 ! cellular component disassembly GO:0022411 64 42 1,000 0,03314221 0,11836504 ! hexose transport GO:0008645 54 42 1,000 0,03314221 0,11818153 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 1,000 0,03314221 0,11799858 ! regulation of cell shape GO:0008360 78 42 1,000 0,03314221 0,1178162 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03357859 0,11918326 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03357859 0,11899962 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03357859 0,11881654 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03357859 0,11863403 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03357859 0,11845207 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03357859 0,11827068 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03357859 0,11808983 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03357859 0,11790954 ! sleep GO:0030431 11 5 0,000 0,03357859 0,1177298 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03357859 0,11755061 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03357859 0,11737196 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03357859 0,11719386 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03357859 0,11701629 ! tongue development GO:0043586 6 5 0,000 0,03357859 0,11683926 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03357859 0,11666277 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03357859 0,1164868 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03357859 0,11631137 ! cobalt ion transport GO:0006824 9 5 0,000 0,03357859 0,11613647 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03357859 0,11596209 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03357859 0,11578823 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03357859 0,1156149 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03357859 0,11544208 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03357859 0,11526978 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03357859 0,11509799 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03357859 0,11492671 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03357859 0,11475595 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03357859 0,11458568 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03357859 0,11441593 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03357859 0,11424667 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03357859 0,11407792 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03357859 0,11390966 ! malate metabolic process GO:0006108 7 5 0,000 0,03357859 0,1137419 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03357859 0,11357463 ! behavioral response to pain GO:0048266 7 5 0,000 0,03357859 0,11340786 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03357859 0,11324157 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03357859 0,11307577 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03357859 0,11291046 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03357859 0,11274562 ! mating behavior GO:0007617 6 5 0,000 0,03357859 0,11258127 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03357859 0,1124174 ! rhythmic behavior GO:0007622 12 5 0,000 0,03357859 0,112254 ! copulation GO:0007620 7 5 0,000 0,03357859 0,11209108 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03357859 0,11192862 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03357859 0,11176664 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03357859 0,11160513 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03357859 0,11144409 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03357859 0,1112835 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03357859 0,11112338 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03357859 0,11096372 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03357859 0,11080452 ! response to protozoan GO:0001562 9 5 0,000 0,03357859 0,11064578 ! lymph vessel development GO:0001945 7 5 0,000 0,03357859 0,11048748 ! endochondral ossification GO:0001958 12 5 0,000 0,03357859 0,11032964 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03357859 0,11017226 ! parathyroid gland development GO:0060017 8 5 0,000 0,03357859 0,11001532 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03357859 0,10985882 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03357859 0,10970277 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03357859 0,10954716 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03357859 0,109392 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03357859 0,10923727 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03357859 0,10908298 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03357859 0,10892913 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03357859 0,10877571 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03357859 0,10862272 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03357859 0,10847016 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03357859 0,10831802 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03357859 0,10816632 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03357859 0,10801504 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03357859 0,10786418 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03357859 0,10771374 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03357859 0,10756372 ! ovulation GO:0030728 6 5 0,000 0,03357859 0,10741412 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03357859 0,10726493 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03357859 0,10711616 ! response to pH GO:0009268 9 5 0,000 0,03357859 0,1069678 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03357859 0,10681985 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03357859 0,10667231 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03357859 0,10652517 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03357859 0,10637845 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03357859 0,10623212 ! polyol catabolic process GO:0046174 7 5 0,000 0,03357859 0,1060862 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03357859 0,10594067 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03357859 0,10579555 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03357859 0,10565082 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03357859 0,10550649 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03357859 0,10536255 ! urea metabolic process GO:0019627 6 5 0,000 0,03357859 0,10521901 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03357859 0,10507585 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03357859 0,10493309 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03357859 0,10479071 ! neutrophil activation GO:0042119 5 5 0,000 0,03357859 0,10464871 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03357859 0,10450711 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03357859 0,10436588 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03357859 0,10422504 GO:0043088|regulation of Cdc42 GTPase activity, ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03357859 0,10408457 ! forebrain neuron development GO:0021884 7 5 0,000 0,03357859 0,10394448 ! melanosome organization GO:0032438 7 5 0,000 0,03357859 0,10380477 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03357859 0,10366544 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03357859 0,10352648 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03357859 0,10338789 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03357859 0,10324967 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03357859 0,10311182 ! nucleoside transport GO:0015858 6 5 0,000 0,03357859 0,10297433 ! nucleoside salvage GO:0043174 7 5 0,000 0,03357859 0,10283722 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03357859 0,10270047 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03357859 0,10256408 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03357859 0,10242805 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03357859 0,10229239 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03357859 0,10215708 ! depyrimidination GO:0045008 8 5 0,000 0,03357859 0,10202213 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03357859 0,10188753 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03357859 0,1017533 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03357859 0,10161941 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03357859 0,10148588 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03357859 0,10135269 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03357859 0,10121986 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03357859 0,10108737 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03357859 0,10095523 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03357859 0,10082344 ! monocyte differentiation GO:0030224 8 5 0,000 0,03357859 0,10069198 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03357859 0,10056087 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03357859 0,10043011 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03357859 0,10029968 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03357859 0,10016959 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03357859 0,10003983 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03357859 0,09991042 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03357859 0,09978133 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03357859 0,09965258 ! melanosome transport GO:0032402 8 5 0,000 0,03357859 0,09952416 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03357859 0,09939608 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03357859 0,09926832 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03357859 0,09914089 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03357859 0,09901378 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03357859 0,09888701 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03357859 0,09876055 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03357859 0,09863442 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03357859 0,09850861 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03357859 0,09838312 ! neural tube patterning GO:0021532 6 5 0,000 0,03357859 0,09825795 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03357859 0,0981331 ! histone demethylation GO:0016577 9 5 0,000 0,03357859 0,09800857 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03357859 0,09788435 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03357859 0,09776044 GO:0032374|regulation of cholesterol transport, ! establishment of planar polarity GO:0001736 6 5 0,000 0,03357859 0,09763685 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03357859 0,09751357 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03357859 0,09739061 ! transcription termination GO:0006353 8 5 0,000 0,03357859 0,09726795 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03357859 0,0971456 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03357859 0,09702356 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03357859 0,09690182 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03357859 0,09678039 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03357859 0,09665926 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03357859 0,09653844 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03357859 0,09641792 ! apical protein localization GO:0045176 6 5 0,000 0,03357859 0,09629769 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03357859 0,09617777 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03357859 0,09605815 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03357859 0,09593882 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03357859 0,09581979 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03357859 0,09570105 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03357859 0,09558261 ! glial cell migration GO:0008347 10 5 0,000 0,03357859 0,09546446 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03357859 0,09534661 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03357859 0,09522904 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03357859 0,09511176 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03357859 0,09499477 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03357859 0,09487807 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03357859 0,09476166 ! neural plate development GO:0001840 6 5 0,000 0,03357859 0,09464553 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03357859 0,09452968 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03357859 0,09441412 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03357859 0,09429884 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03357859 0,09418384 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03357859 0,09406912 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03357859 0,09395469 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03357859 0,09384052 ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03357859 0,09372664 ! spindle assembly GO:0051225 5 5 0,000 0,03357859 0,09361303 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03357859 0,0934997 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03357859 0,09338664 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03357859 0,09327385 ! organ regeneration GO:0031100 7 5 0,000 0,03357859 0,09316134 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03357859 0,0930491 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03357859 0,09293713 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03357859 0,09282542 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03357859 0,09271399 GO:0055081|anion homeostasis, ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,03460708 0,0954392 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,03460708 0,0953249 ! methylation GO:0032259 64 43 1,000 0,03460708 0,09521088 ! regulation of action potential GO:0001508 71 44 1,000 0,03609677 0,09919066 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,03609677 0,09907229 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,03914901 0,10732147 ! tRNA transcription GO:0009304 11 6 0,000 0,0401589 0,1099589 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,0401589 0,10982815 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,0401589 0,10969771 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,0401589 0,10956758 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0401589 0,10943776 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,0401589 0,10930825 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,0401589 0,10917905 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,0401589 0,10905015 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,0401589 0,10892155 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,0401589 0,10879325 ! prostate gland development GO:0030850 9 6 0,000 0,0401589 0,10866526 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,0401589 0,10853757 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,0401589 0,10841018 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,0401589 0,10828309 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,0401589 0,10815629 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,0401589 0,10802979 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,0401589 0,10790359 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,0401589 0,10777768 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,0401589 0,10765207 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,0401589 0,10752674 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,0401589 0,10740171 ! signal peptide processing GO:0006465 8 6 0,000 0,0401589 0,10727697 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,0401589 0,10715252 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,0401589 0,10702836 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,0401589 0,10690448 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,0401589 0,10678089 ! opsonization GO:0008228 8 6 0,000 0,0401589 0,10665759 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,0401589 0,10653457 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,0401589 0,10641184 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,0401589 0,10628938 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,0401589 0,10616721 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,0401589 0,10604532 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0401589 0,10592371 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,0401589 0,10580238 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,0401589 0,10568132 ! mechanosensory behavior GO:0007638 8 6 0,000 0,0401589 0,10556054 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,0401589 0,10544004 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,0401589 0,10531981 ! response to interferon-gamma GO:0034341 12 6 0,000 0,0401589 0,10519986 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,0401589 0,10508017 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,0401589 0,10496077 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0401589 0,10484163 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,0401589 0,10472276 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,0401589 0,10460416 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,0401589 0,10448583 ! protein lipoylation GO:0009249 10 6 0,000 0,0401589 0,10436777 ! pigment granule organization GO:0048753 11 6 0,000 0,0401589 0,10424997 ! drug transport GO:0015893 6 6 0,000 0,0401589 0,10413244 ! cysteine metabolic process GO:0006534 7 6 0,000 0,0401589 0,10401517 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,0401589 0,10389817 ! histidine metabolic process GO:0006547 6 6 0,000 0,0401589 0,10378143 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,0401589 0,10366495 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,0401589 0,10354874 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,0401589 0,10343278 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,0401589 0,10331708 ! adenohypophysis development GO:0021984 10 6 0,000 0,0401589 0,10320165 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,0401589 0,10308647 ! hyperosmotic response GO:0006972 8 6 0,000 0,0401589 0,10297154 ! microtubule nucleation GO:0007020 10 6 0,000 0,0401589 0,10285687 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,0401589 0,10274246 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,0401589 0,1026283 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,0401589 0,1025144 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,0401589 0,10240075 ! response to dietary excess GO:0002021 7 6 0,000 0,0401589 0,10228735 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,0401589 0,1021742 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,0401589 0,1020613 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,0401589 0,10194865 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,0401589 0,10183624 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,0401589 0,10172409 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0401589 0,10161218 ! neuron apoptosis GO:0051402 8 6 0,000 0,0401589 0,10150052 ! organic alcohol transport GO:0015850 9 6 0,000 0,0401589 0,1013891 ! T cell mediated immunity GO:0002456 12 6 0,000 0,0401589 0,10127793 ! carnitine transport GO:0015879 8 6 0,000 0,0401589 0,101167 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,0401589 0,10105632 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,0401589 0,10094587 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,0401589 0,10083567 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,0401589 0,10072571 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,0401589 0,10061598 ! parturition GO:0007567 12 6 0,000 0,0401589 0,1005065 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,0401589 0,10039725 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,0401589 0,10028824 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,0401589 0,10017947 ! spindle checkpoint GO:0031577 14 6 0,000 0,0401589 0,10007094 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,0401589 0,09996263 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,0401589 0,09985457 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,0401589 0,09974673 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,0401589 0,09963913 ! macrophage differentiation GO:0030225 10 6 0,000 0,0401589 0,09953176 ! astrocyte development GO:0014002 14 6 0,000 0,0401589 0,09942462 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,0401589 0,09931771 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,0401589 0,09921103 ! interaction with symbiont GO:0051702 8 6 0,000 0,0401589 0,09910459 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,0401589 0,09899836 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0401589 0,09889237 ! eating behavior GO:0042755 6 6 0,000 0,0401589 0,0987866 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,0401589 0,09868106 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,0401589 0,09857575 ! response to copper ion GO:0046688 9 6 0,000 0,0401589 0,09847065 ! DNA topological change GO:0006265 8 6 0,000 0,0401589 0,09836579 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,0401589 0,09826114 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,0401589 0,09815672 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,0401589 0,09805252 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0401589 0,09794854 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,0401589 0,09784478 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,0401589 0,09774124 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,0401589 0,09763792 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,0401589 0,09753482 ! Schwann cell development GO:0014044 14 6 0,000 0,0401589 0,09743193 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,0401589 0,09732927 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,0401589 0,09722681 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0401589 0,09712458 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,0401589 0,09702256 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,0401589 0,09692075 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,0401589 0,09681915 ! histone ubiquitination GO:0016574 7 6 0,000 0,0401589 0,09671777 ! regulation of meiosis GO:0040020 10 6 0,000 0,0401589 0,0966166 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,0401589 0,09651565 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,0401589 0,0964149 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,0401589 0,09631436 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,0401589 0,09621403 ! membrane to membrane docking GO:0022614 12 6 0,000 0,0401589 0,09611392 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,0401589 0,09601401 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,0401589 0,0959143 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,0401589 0,09581481 ! receptor internalization GO:0031623 9 6 0,000 0,0401589 0,09571552 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,0401589 0,09561643 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,0401589 0,09551755 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0401589 0,09541888 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,0401589 0,09532041 ! protein deubiquitination GO:0016579 8 6 0,000 0,0401589 0,09522214 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,0401589 0,09512407 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,0401589 0,09502621 ! axonal fasciculation GO:0007413 9 6 0,000 0,0401589 0,09492854 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,0401589 0,09483108 ! thiamin metabolic process GO:0006772 6 6 0,000 0,0401589 0,09473382 ! midbrain development GO:0030901 6 6 0,000 0,0401589 0,09463676 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,0401589 0,09453989 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0401589 0,09444322 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,0401589 0,09434676 ! progesterone metabolic process GO:0042448 8 6 0,000 0,0401589 0,09425048 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,0401589 0,09415441 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,0401589 0,09405853 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,0401589 0,09396284 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,0401589 0,09386735 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,0401589 0,09377205 ! adult feeding behavior GO:0008343 6 6 0,000 0,0401589 0,09367695 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,0401589 0,09358204 ! pigment granule transport GO:0051904 12 6 0,000 0,0401589 0,09348732 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,0401589 0,09339279 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,0401589 0,09329846 ! catecholamine transport GO:0051937 7 6 0,000 0,0401589 0,09320431 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0401589 0,09311036 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,0401589 0,09301659 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,0401589 0,09292301 ! protein prenylation GO:0018342 10 6 0,000 0,0401589 0,09282962 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0401589 0,09273642 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,0401589 0,0926434 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,0401589 0,09255057 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,0401589 0,09245793 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,04071076 0,09363476 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04071076 0,09354122 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04229576 0,09708609 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,04229576 0,09698929 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,04390363 0,10057603 ! maintenance of location GO:0051235 84 49 1,000 0,04390363 0,10047596 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,04553397 0,1041035 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,04553397 0,10400012 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04669478 0,10654564 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04669478 0,10644004 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04669478 0,10633466 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04669478 0,10622948 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04669478 0,10612451 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04669478 0,10601975 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04669478 0,10591519 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04669478 0,10581084 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04669478 0,1057067 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04669478 0,10560276 ! reproductive behavior GO:0019098 12 7 0,000 0,04669478 0,10549902 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04669478 0,10539549 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,04669478 0,10529216 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04669478 0,10518903 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,04669478 0,10508611 ! oligopeptide transport GO:0006857 11 7 0,000 0,04669478 0,10498339 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04669478 0,10488086 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04669478 0,10477854 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04669478 0,10467642 ! RNA methylation GO:0001510 11 7 0,000 0,04669478 0,10457449 ! pericardium development GO:0060039 8 7 0,000 0,04669478 0,10447277 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04669478 0,10437124 ! fibril organization GO:0043206 13 7 0,000 0,04669478 0,10426991 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04669478 0,10416877 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04669478 0,10406783 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,04669478 0,10396709 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04669478 0,10386654 ! lipoprotein transport GO:0042953 9 7 0,000 0,04669478 0,10376619 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04669478 0,10366603 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04669478 0,10356606 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04669478 0,10346629 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04669478 0,1033667 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04669478 0,10326731 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04669478 0,10316811 ! chemosensory behavior GO:0007635 9 7 0,000 0,04669478 0,1030691 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04669478 0,10297028 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04669478 0,10287165 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04669478 0,10277321 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04669478 0,10267496 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04669478 0,10257689 ! reflex GO:0060004 12 7 0,000 0,04669478 0,10247901 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04669478 0,10238132 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04669478 0,10228381 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04669478 0,10218649 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04669478 0,10208936 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04669478 0,10199241 ! spinal cord patterning GO:0021511 7 7 0,000 0,04669478 0,10189564 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04669478 0,10179906 ! adrenal gland development GO:0030325 17 7 0,000 0,04669478 0,10170266 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04669478 0,10160644 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04669478 0,1015104 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04669478 0,10141455 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04669478 0,10131887 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04669478 0,10122338 ! endosome organization GO:0007032 10 7 0,000 0,04669478 0,10112806 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04669478 0,10103293 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04669478 0,10093797 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04669478 0,1008432 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04669478 0,1007486 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04669478 0,10065417 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04669478 0,10055993 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04669478 0,10046586 ! galactose metabolic process GO:0006012 10 7 0,000 0,04669478 0,10037197 ! vesicle fusion GO:0006906 15 7 0,000 0,04669478 0,10027825 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04669478 0,10018471 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04669478 0,10009134 ! organ growth GO:0035265 11 7 0,000 0,04669478 0,09999814 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04669478 0,09990512 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04669478 0,09981227 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04669478 0,0997196 ! behavioral fear response GO:0001662 13 7 0,000 0,04669478 0,09962709 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04669478 0,09953476 ! rRNA modification GO:0000154 12 7 0,000 0,04669478 0,0994426 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04669478 0,09935061 ! response to UV-B GO:0010224 11 7 0,000 0,04669478 0,09925878 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04669478 0,09916713 ! intermediate filament organization GO:0045109 11 7 0,000 0,04669478 0,09907565 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04669478 0,09898434 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04669478 0,09889319 ! fibrinolysis GO:0042730 9 7 0,000 0,04669478 0,09880221 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04669478 0,0987114 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04669478 0,09862076 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04669478 0,09853028 ! response to tropane GO:0014073 13 7 0,000 0,04669478 0,09843997 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04669478 0,09834982 ! melanosome localization GO:0032400 10 7 0,000 0,04669478 0,09825984 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04669478 0,09817002 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04669478 0,09808037 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04669478 0,09799088 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04669478 0,09790155 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04669478 0,09781239 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04669478 0,09772339 ! mast cell activation GO:0045576 9 7 0,000 0,04669478 0,09763455 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04669478 0,09754587 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04669478 0,09745735 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04669478 0,097369 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04669478 0,0972808 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04669478 0,09719276 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04669478 0,09710489 ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04669478 0,09701717 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04669478 0,09692961 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04669478 0,0968422 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04669478 0,09675496 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04669478 0,09666787 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04669478 0,09658094 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04669478 0,09649416 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04669478 0,09640754 ! diuresis GO:0030146 12 7 0,000 0,04669478 0,09632108 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04669478 0,09623477 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04669478 0,09614862 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04669478 0,09606262 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04669478 0,09597677 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04669478 0,09589108 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04669478 0,09580553 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04669478 0,09572015 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04669478 0,09563491 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04669478 0,09554983 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04669478 0,09546489 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04669478 0,09538011 ! lymph node development GO:0048535 9 7 0,000 0,04669478 0,09529548 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04669478 0,095211 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04669478 0,09512666 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04669478 0,09504248 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04669478 0,09495845 ! ATP catabolic process GO:0006200 10 7 0,000 0,04669478 0,09487456 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04669478 0,09479082 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04669478 0,09470723 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04669478 0,09462379 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04669478 0,0945405 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04669478 0,09445735 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04669478 0,09437434 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04669478 0,09429149 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04669478 0,09420878 ! retina homeostasis GO:0001895 9 7 0,000 0,04669478 0,09412621 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04669478 0,09404379 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04669478 0,09396151 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04669478 0,09387937 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04669478 0,09379738 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04669478 0,09371554 ! positive regulation of secretion GO:0051047 71 51 1,000 0,04718642 0,09461966 ! muscle fiber development GO:0048747 74 51 1,000 0,04718642 0,09453724 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,05055615 0,1012003 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,05055615 0,1011123 ! amino acid transport GO:0006865 84 54 1,000 0,05227271 0,10445459 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,05227271 0,10436392 ! DNA catabolic process GO:0006308 67 54 1,000 0,05227271 0,1042734 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,05227271 0,10418304 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05318653 0,10591258 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05318653 0,10582096 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05318653 0,1057295 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05318653 0,10563819 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05318653 0,10554705 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05318653 0,10545606 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05318653 0,10536523 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05318653 0,10527455 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05318653 0,10518403 ! phosphate transport GO:0006817 10 8 0,000 0,05318653 0,10509367 ! N-glycan processing GO:0006491 12 8 0,000 0,05318653 0,10500346 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05318653 0,1049134 ! UTP metabolic process GO:0046051 8 8 0,000 0,05318653 0,1048235 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05318653 0,10473376 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05318653 0,10464416 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05318653 0,10455472 ! succinate metabolic process GO:0006105 14 8 0,000 0,05318653 0,10446544 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05318653 0,1043763 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05318653 0,10428732 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,05318653 0,10419849 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05318653 0,10410981 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,05318653 0,10402128 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05318653 0,1039329 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05318653 0,10384468 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05318653 0,1037566 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05318653 0,10366867 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05318653 0,10358089 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05318653 0,10349326 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05318653 0,10340577 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05318653 0,10331844 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05318653 0,10323125 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05318653 0,10314421 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05318653 0,10305731 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05318653 0,10297056 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05318653 0,10288396 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05318653 0,1027975 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05318653 0,10271119 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05318653 0,10262502 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05318653 0,102539 ! melanin metabolic process GO:0006582 12 8 0,000 0,05318653 0,10245312 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05318653 0,10236739 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05318653 0,1022818 ! macrophage activation GO:0042116 12 8 0,000 0,05318653 0,10219635 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05318653 0,10211104 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05318653 0,10202588 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05318653 0,10194086 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05318653 0,10185598 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05318653 0,10177124 ! ruffle organization GO:0031529 11 8 0,000 0,05318653 0,10168664 ! osteoblast development GO:0002076 13 8 0,000 0,05318653 0,10160218 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05318653 0,10151787 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05318653 0,10143369 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05318653 0,10134965 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05318653 0,10126575 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05318653 0,10118199 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05318653 0,10109837 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05318653 0,10101489 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05318653 0,10093154 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05318653 0,10084833 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05318653 0,10076526 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05318653 0,10068233 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05318653 0,10059953 ! segment specification GO:0007379 10 8 0,000 0,05318653 0,10051687 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05318653 0,10043434 ! cellular extravasation GO:0045123 11 8 0,000 0,05318653 0,10035195 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05318653 0,10026969 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05318653 0,10018757 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05318653 0,10010559 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05318653 0,10002373 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05318653 0,09994202 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05318653 0,09986043 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05318653 0,09977898 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05318653 0,09969766 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05318653 0,09961647 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05318653 0,09953542 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05318653 0,09945449 ! icosanoid secretion GO:0032309 12 8 0,000 0,05318653 0,0993737 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05318653 0,09929304 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05318653 0,09921251 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05318653 0,09913211 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05318653 0,09905184 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05318653 0,09897171 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05318653 0,0988917 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05318653 0,09881182 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05318653 0,09873206 ! sterol catabolic process GO:0016127 9 8 0,000 0,05318653 0,09865244 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05318653 0,09857295 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05318653 0,09849358 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05318653 0,09841434 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05318653 0,09833523 ! prophase GO:0051324 11 8 0,000 0,05318653 0,09825625 ! S phase GO:0051320 8 8 0,000 0,05318653 0,09817739 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05318653 0,09809866 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05318653 0,09802005 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05318653 0,09794158 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05318653 0,09786322 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05318653 0,09778499 ! hormone catabolic process GO:0042447 13 8 0,000 0,05318653 0,09770689 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05318653 0,09762891 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05318653 0,09755106 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05318653 0,09747333 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05318653 0,09739572 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05318653 0,09731824 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,05318653 0,09724088 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05318653 0,09716364 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05318653 0,09708653 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05318653 0,09700954 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05318653 0,09693267 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05318653 0,09685592 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05318653 0,09677929 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05318653 0,09670279 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05318653 0,0966264 ! carbohydrate transport GO:0008643 74 57 1,000 0,05754485 0,10446184 ! chromosome segregation GO:0007059 83 57 1,000 0,05754485 0,10437945 ! camera-type eye development GO:0043010 88 57 1,000 0,05754485 0,1042972 ! secondary metabolic process GO:0019748 84 57 1,000 0,05754485 0,10421508 ! gonad development GO:0008406 79 57 1,000 0,05754485 0,10413308 ! viral reproductive process GO:0022415 87 58 1,000 0,05934188 0,10730056 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05963445 0,10774487 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05963445 0,1076603 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05963445 0,10757586 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05963445 0,10749155 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05963445 0,10740738 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05963445 0,10732334 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05963445 0,10723942 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05963445 0,10715564 ! GTP metabolic process GO:0046039 9 9 0,000 0,05963445 0,10707199 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05963445 0,10698847 ! social behavior GO:0035176 14 9 0,000 0,05963445 0,10690508 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05963445 0,10682183 ! artery development GO:0060840 19 9 0,000 0,05963445 0,1067387 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05963445 0,1066557 ! response to pain GO:0048265 16 9 0,000 0,05963445 0,10657282 ! protein complex disassembly GO:0043241 17 9 0,000 0,05963445 0,10649008 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05963445 0,10640747 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05963445 0,10632498 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05963445 0,10624262 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05963445 0,10616039 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05963445 0,10607829 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05963445 0,10599631 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05963445 0,10591446 ! protein targeting to ER GO:0045047 19 9 0,000 0,05963445 0,10583273 ! endoderm development GO:0007492 12 9 0,000 0,05963445 0,10575114 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05963445 0,10566966 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05963445 0,10558832 ! arginine catabolic process GO:0006527 10 9 0,000 0,05963445 0,1055071 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05963445 0,105426 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05963445 0,10534503 GO:0010833|telomere maintenance via telomere lengthening, ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05963445 0,10526418 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05963445 0,10518345 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05963445 0,10510285 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05963445 0,10502238 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05963445 0,10494202 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05963445 0,10486179 ! mannose metabolic process GO:0006013 9 9 0,000 0,05963445 0,10478168 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05963445 0,1047017 ! epithelial cell development GO:0002064 10 9 0,000 0,05963445 0,10462183 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05963445 0,10454209 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05963445 0,10446247 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05963445 0,10438297 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05963445 0,10430359 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05963445 0,10422433 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,05963445 0,1041452 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05963445 0,10406618 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05963445 0,10398728 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05963445 0,1039085 ! DNA ligation GO:0006266 14 9 0,000 0,05963445 0,10382984 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05963445 0,1037513 ! response to amine stimulus GO:0014075 13 9 0,000 0,05963445 0,10367288 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05963445 0,10359458 ! erythrocyte development GO:0048821 11 9 0,000 0,05963445 0,1035164 ! renal water homeostasis GO:0003091 14 9 0,000 0,05963445 0,10343833 ! postreplication repair GO:0006301 11 9 0,000 0,05963445 0,10336038 ! mRNA cleavage GO:0006379 13 9 0,000 0,05963445 0,10328255 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05963445 0,10320483 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05963445 0,10312724 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05963445 0,10304976 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05963445 0,10297239 ! acid secretion GO:0046717 14 9 0,000 0,05963445 0,10289514 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05963445 0,10281801 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05963445 0,10274099 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05963445 0,10266409 ! purine base metabolic process GO:0006144 18 9 0,000 0,05963445 0,1025873 ! thymus development GO:0048538 15 9 0,000 0,05963445 0,10251063 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05963445 0,10243407 ! spleen development GO:0048536 15 9 0,000 0,05963445 0,10235763 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,05963445 0,1022813 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05963445 0,10220508 ! detection of calcium ion GO:0005513 13 9 0,000 0,05963445 0,10212898 ! blastocyst formation GO:0001825 12 9 0,000 0,05963445 0,10205299 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05963445 0,10197712 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05963445 0,10190136 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05963445 0,1018257 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05963445 0,10175017 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05963445 0,10167474 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05963445 0,10159943 ! prepulse inhibition GO:0060134 14 9 0,000 0,05963445 0,10152422 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05963445 0,10144913 ! insulin secretion GO:0030073 17 9 0,000 0,05963445 0,10137415 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05963445 0,10129928 ! response to nicotine GO:0035094 16 9 0,000 0,05963445 0,10122452 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05963445 0,10114987 ! nucleus localization GO:0051647 15 9 0,000 0,05963445 0,10107533 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05963445 0,1010009 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,06115815 0,10350533 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,06299334 0,10653285 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,06299334 0,10645457 GO:0035113|embryonic appendage morphogenesis, ! meiosis GO:0007126 96 61 1,000 0,06484709 0,10950684 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 1,000 0,06484709 0,1094265 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06603881 0,11135577 ! neuron fate specification GO:0048665 11 10 0,000 0,06603881 0,11127419 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06603881 0,11119273 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06603881 0,11111139 ! thyroid gland development GO:0030878 19 10 0,000 0,06603881 0,11103017 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06603881 0,11094906 ! synapsis GO:0007129 13 10 0,000 0,06603881 0,11086808 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06603881 0,11078721 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06603881 0,11070646 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,06603881 0,11062583 ! sulfate transport GO:0008272 12 10 0,000 0,06603881 0,11054532 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06603881 0,11046492 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06603881 0,11038464 ! androgen metabolic process GO:0008209 13 10 0,000 0,06603881 0,11030448 ! phospholipid efflux GO:0033700 16 10 0,000 0,06603881 0,11022443 ! hippocampus development GO:0021766 19 10 0,000 0,06603881 0,1101445 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06603881 0,11006469 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06603881 0,10998499 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06603881 0,1099054 ! pathogenesis GO:0009405 13 10 0,000 0,06603881 0,10982593 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06603881 0,10974658 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06603881 0,10966734 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06603881 0,10958822 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06603881 0,10950921 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06603881 0,10943031 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06603881 0,10935152 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06603881 0,10927285 ! B cell proliferation GO:0042100 14 10 0,000 0,06603881 0,1091943 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06603881 0,10911585 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06603881 0,10903752 ! forebrain cell migration GO:0021885 17 10 0,000 0,06603881 0,1089593 ! lipid digestion GO:0044241 15 10 0,000 0,06603881 0,1088812 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06603881 0,1088032 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06603881 0,10872532 ! UV protection GO:0009650 14 10 0,000 0,06603881 0,10864754 ! entry into host cell GO:0030260 20 10 0,000 0,06603881 0,10856988 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,06603881 0,10849233 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06603881 0,10841489 ! negative regulation of ossification GO:0030279 19 10 0,000 0,06603881 0,10833757 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,06603881 0,10826035 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06603881 0,10818324 ! regulation of organ growth GO:0046620 11 10 0,000 0,06603881 0,10810624 ! response to dsRNA GO:0043331 18 10 0,000 0,06603881 0,10802935 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06603881 0,10795257 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06603881 0,1078759 ! embryonic axis specification GO:0000578 12 10 0,000 0,06603881 0,10779934 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06603881 0,10772288 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06603881 0,10764654 ! cranial nerve development GO:0021545 12 10 0,000 0,06603881 0,1075703 ! fucose catabolic process GO:0019317 16 10 0,000 0,06603881 0,10749417 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,06603881 0,10741815 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06603881 0,10734224 ! protein sumoylation GO:0016925 12 10 0,000 0,06603881 0,10726643 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06603881 0,10719073 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06603881 0,10711514 ! zymogen activation GO:0031638 14 10 0,000 0,06603881 0,10703965 ! salivary gland development GO:0007431 22 10 0,000 0,06603881 0,10696427 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06603881 0,106889 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06603881 0,10681383 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06603881 0,10673877 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06603881 0,10666381 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06603881 0,10658896 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06603881 0,10651421 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06603881 0,10643957 ! detection of bacterium GO:0016045 10 10 0,000 0,06603881 0,10636503 ! embryonic gut development GO:0048566 11 10 0,000 0,06603881 0,1062906 ! activation of innate immune response GO:0002218 10 10 0,000 0,06603881 0,10621627 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06603881 0,10614205 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06603881 0,10606792 ! developmental induction GO:0031128 13 10 0,000 0,06603881 0,10599391 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06603881 0,10591999 ! cellular hormone metabolic process GO:0034754 87 62 1,000 0,06671909 0,10693652 ! meiotic cell cycle GO:0051321 97 62 1,000 0,06671909 0,10686205 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,06860899 0,10981258 ! viral reproduction GO:0016032 92 63 1,000 0,06860899 0,10973622 ! appendage morphogenesis GO:0035107 93 64 1,000 0,07051648 0,11270876 GO:0035108|limb morphogenesis, ! adaptive immune response GO:0002250 94 64 1,000 0,07051648 0,11263049 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! rRNA transcription GO:0009303 17 11 0,000 0,07239993 0,11555852 ! respiratory burst GO:0045730 14 11 0,000 0,07239993 0,11547838 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07239993 0,11539836 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07239993 0,11531844 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07239993 0,11523864 ! filopodium assembly GO:0046847 19 11 0,000 0,07239993 0,11515894 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07239993 0,11507936 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07239993 0,11499988 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,07239993 0,11492052 ! mating GO:0007618 14 11 0,000 0,07239993 0,11484126 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07239993 0,11476212 ! bone resorption GO:0045453 16 11 0,000 0,07239993 0,11468308 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07239993 0,11460415 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07239993 0,11452533 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07239993 0,11444662 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07239993 0,11436801 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07239993 0,11428952 ! syncytium formation GO:0006949 15 11 0,000 0,07239993 0,11421113 ! plasma membrane organization GO:0007009 18 11 0,000 0,07239993 0,11413285 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07239993 0,11405468 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07239993 0,11397661 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07239993 0,11389865 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07239993 0,1138208 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07239993 0,11374305 ! adult heart development GO:0007512 11 11 0,000 0,07239993 0,11366541 ! temperature homeostasis GO:0001659 16 11 0,000 0,07239993 0,11358788 ! L-glutamate transport GO:0015813 16 11 0,000 0,07239993 0,11351045 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07239993 0,11343313 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07239993 0,11335591 ! stem cell development GO:0048864 29 11 0,000 0,07239993 0,1132788 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07239993 0,11320179 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07239993 0,11312488 ! vasoconstriction GO:0042310 15 11 0,000 0,07239993 0,11304809 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07239993 0,11297139 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07239993 0,1128948 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07239993 0,11281831 ! ribosome assembly GO:0042255 13 11 0,000 0,07239993 0,11274193 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07239993 0,11266565 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07239993 0,11258947 ! chromatin silencing GO:0006342 19 11 0,000 0,07239993 0,1125134 ! nucleosome positioning GO:0016584 13 11 0,000 0,07239993 0,11243743 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07239993 0,11236156 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07239993 0,11228579 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07239993 0,11221013 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07239993 0,11213457 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07239993 0,1120591 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07239993 0,11198375 ! male genitalia development GO:0030539 13 11 0,000 0,07239993 0,11190849 ! cholesterol efflux GO:0033344 19 11 0,000 0,07239993 0,11183333 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07239993 0,11175827 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07239993 0,11168332 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07239993 0,11160846 ! germ cell migration GO:0008354 18 11 0,000 0,07239993 0,11153371 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07239993 0,11145906 ! defense response to fungus GO:0050832 12 11 0,000 0,07239993 0,1113845 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07239993 0,11131005 ! lysogeny GO:0030069 18 11 0,000 0,07239993 0,11123569 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07239993 0,11116143 ! acrosome reaction GO:0007340 13 11 0,000 0,07239993 0,11108728 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07239993 0,11101322 ! appendage development GO:0048736 94 65 1,000 0,07244123 0,11100255 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,07244123 0,11092864 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,07244123 0,11085484 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,07244123 0,11078113 ! activation of immune response GO:0002253 83 65 1,000 0,07244123 0,11070752 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,07634124 0,1165902 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,07831587 0,11952655 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,07831587 0,11944728 ! lactation GO:0007595 20 12 0,000 0,07871808 0,11998116 ! reproductive cellular process GO:0048610 14 12 0,000 0,07871808 0,11990171 ! tRNA modification GO:0006400 14 12 0,000 0,07871808 0,11982235 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,07871808 0,11974311 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07871808 0,11966396 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07871808 0,11958492 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07871808 0,11950599 ! non-recombinational repair GO:0000726 19 12 0,000 0,07871808 0,11942716 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07871808 0,11934843 ! peroxisomal transport GO:0043574 21 12 0,000 0,07871808 0,11926981 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,07871808 0,11919129 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07871808 0,11911288 ! palate development GO:0060021 15 12 0,000 0,07871808 0,11903457 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,07871808 0,11895636 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07871808 0,11887825 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,07871808 0,11880025 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07871808 0,11872234 ! arginine metabolic process GO:0006525 13 12 0,000 0,07871808 0,11864455 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07871808 0,11856685 ! methionine metabolic process GO:0006555 13 12 0,000 0,07871808 0,11848925 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07871808 0,11841176 ! Golgi organization GO:0007030 18 12 0,000 0,07871808 0,11833436 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,07871808 0,11825707 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07871808 0,11817988 ! monoamine transport GO:0015844 13 12 0,000 0,07871808 0,11810279 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07871808 0,1180258 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07871808 0,11794891 ! L-amino acid transport GO:0015807 20 12 0,000 0,07871808 0,11787212 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07871808 0,11779543 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07871808 0,11771884 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07871808 0,11764235 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07871808 0,11756596 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07871808 0,11748967 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07871808 0,11741347 ! cerebellum development GO:0021549 13 12 0,000 0,07871808 0,11733738 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07871808 0,11726138 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,07871808 0,11718549 ! histone methylation GO:0016571 15 12 0,000 0,07871808 0,11710969 ! gland morphogenesis GO:0022612 23 12 0,000 0,07871808 0,11703399 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07871808 0,11695838 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07871808 0,11688288 ! regulation of epidermis development GO:0045682 17 12 0,000 0,07871808 0,11680747 ! intestinal absorption GO:0050892 19 12 0,000 0,07871808 0,11673216 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07871808 0,11665694 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07871808 0,11658183 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,07871808 0,11650681 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07871808 0,11643188 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,07871808 0,11635705 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07871808 0,11628232 ! response to cold GO:0009409 14 12 0,000 0,07871808 0,11620769 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,08030651 0,11847657 ! response to drug GO:0042493 108 69 1,000 0,08030651 0,11840063 ! eye development GO:0001654 111 70 1,000 0,08231286 0,12128095 ! amine transport GO:0015837 101 70 1,000 0,08231286 0,12120331 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08499355 0,12507049 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08499355 0,12499052 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08499355 0,12491065 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,08499355 0,12483089 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08499355 0,12475122 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08499355 0,12467166 ! lipid localization GO:0010876 24 13 0,000 0,08499355 0,1245922 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08499355 0,12451285 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08499355 0,12443359 ! organelle fusion GO:0048284 28 13 0,000 0,08499355 0,12435443 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08499355 0,12427538 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,08499355 0,12419642 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08499355 0,12411757 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08499355 0,12403881 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08499355 0,12396016 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08499355 0,1238816 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08499355 0,12380315 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08499355 0,12372479 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08499355 0,12364653 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08499355 0,12356837 ! NAD metabolic process GO:0019674 21 13 0,000 0,08499355 0,12349031 ! exocrine system development GO:0035272 27 13 0,000 0,08499355 0,12341235 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,08499355 0,12333449 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08499355 0,12325673 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08499355 0,12317906 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08499355 0,12310149 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08499355 0,12302402 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08499355 0,12294665 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08499355 0,12286937 ! cellular pigmentation GO:0033059 24 13 0,000 0,08499355 0,12279219 ! tissue regeneration GO:0042246 21 13 0,000 0,08499355 0,12271511 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,08499355 0,12263812 ! cofactor transport GO:0051181 19 13 0,000 0,08499355 0,12256123 ! NADP metabolic process GO:0006739 18 13 0,000 0,08499355 0,12248444 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08499355 0,12240774 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08499355 0,12233114 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08499355 0,12225464 ! gas transport GO:0015669 18 13 0,000 0,08499355 0,12217823 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08499355 0,12210192 ! regulation of axon extension GO:0030516 23 13 0,000 0,08499355 0,1220257 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08499355 0,12194957 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08499355 0,12187355 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08499355 0,12179761 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08499355 0,12172177 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08499355 0,12164603 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,08637144 0,12354125 ! regulation of blood pressure GO:0008217 107 73 1,000 0,0884231 0,12639722 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,0884231 0,12631871 ! digestion GO:0007586 97 74 1,000 0,09048927 0,12919014 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09122664 0,13016207 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,09122664 0,13008138 ! superoxide anion generation GO:0042554 18 14 0,000 0,09122664 0,13000078 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09122664 0,12992029 ! myotube differentiation GO:0014902 21 14 0,000 0,09122664 0,12983989 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09122664 0,12975959 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09122664 0,1296794 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09122664 0,1295993 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09122664 0,1295193 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09122664 0,1294394 ! response to cAMP GO:0051591 19 14 0,000 0,09122664 0,1293596 ! limbic system development GO:0021761 25 14 0,000 0,09122664 0,12927989 ! startle response GO:0001964 21 14 0,000 0,09122664 0,12920029 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09122664 0,12912078 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09122664 0,12904137 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09122664 0,12896206 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09122664 0,12888284 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,09122664 0,12880372 ! glycine metabolic process GO:0006544 22 14 0,000 0,09122664 0,1287247 ! pituitary gland development GO:0021983 23 14 0,000 0,09122664 0,12864578 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09122664 0,12856695 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09122664 0,12848822 ! regulation of heart rate GO:0002027 23 14 0,000 0,09122664 0,12840959 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09122664 0,12833105 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09122664 0,12825261 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,09122664 0,12817426 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,09122664 0,12809601 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09122664 0,12801786 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09122664 0,1279398 ! axon cargo transport GO:0008088 27 14 0,000 0,09122664 0,12786183 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09122664 0,12778396 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09122664 0,12770619 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09122664 0,12762851 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09122664 0,12755092 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09122664 0,12747343 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09122664 0,12739603 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09122664 0,12731873 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09122664 0,12724152 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09122664 0,1271644 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09122664 0,12708738 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09122664 0,12701045 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09122664 0,12693361 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09122664 0,12685687 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09122664 0,12678022 ! cell killing GO:0001906 20 14 0,000 0,09122664 0,12670366 ! cilium assembly GO:0042384 20 14 0,000 0,09122664 0,1266272 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09122664 0,12655082 ! amine biosynthetic process GO:0009309 97 76 1,000 0,094664 0,13124002 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,094664 0,13116096 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,09677199 0,13400095 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,09677199 0,13392032 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,09677199 0,13383979 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,09741762 0,13465175 ! positive regulation of cell size GO:0045793 20 15 0,000 0,09741762 0,13457088 ! metencephalon development GO:0022037 19 15 0,000 0,09741762 0,13449011 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,09741762 0,13440943 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,09741762 0,13432885 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,09741762 0,13424836 ! skin development GO:0043588 25 15 0,000 0,09741762 0,13416797 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,09741762 0,13408768 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,09741762 0,13400749 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,09741762 0,13392739 ! bile acid metabolic process GO:0008206 22 15 0,000 0,09741762 0,13384738 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,09741762 0,13376747 ! adult walking behavior GO:0007628 25 15 0,000 0,09741762 0,13368766 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,09741762 0,13360794 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,09741762 0,13352832 ! myoblast differentiation GO:0045445 27 15 0,000 0,09741762 0,13344879 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,09741762 0,13336936 ! cerebral cortex development GO:0021987 29 15 0,000 0,09741762 0,13329002 ! response to osmotic stress GO:0006970 22 15 0,000 0,09741762 0,13321077 ! vesicle coating GO:0006901 25 15 0,000 0,09741762 0,13313162 ! DNA integration GO:0015074 22 15 0,000 0,09741762 0,13305256 ! peptide secretion GO:0002790 27 15 0,000 0,09741762 0,1329736 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,09741762 0,13289473 ! regulation of vasodilation GO:0042312 24 15 0,000 0,09741762 0,13281596 ! neuron recognition GO:0008038 22 15 0,000 0,09741762 0,13273727 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,09741762 0,13265868 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,09741762 0,13258019 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,09741762 0,13250178 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,09741762 0,13242347 ! dopamine metabolic process GO:0042417 30 15 0,000 0,09741762 0,13234526 ! organic cation transport GO:0015695 19 15 0,000 0,09741762 0,13226713 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,09741762 0,1321891 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,09741762 0,13211115 ! peptide hormone processing GO:0016486 19 15 0,000 0,09741762 0,1320333 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,09741762 0,13195555 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,09889336 0,13387566 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,10102784 0,13668473 ! regulation of lyase activity GO:0051339 133 79 1,000 0,10102784 0,13660437 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,10317515 0,13942588 ! protein secretion GO:0009306 27 16 0,000 0,10356677 0,13987292 ! hormone secretion GO:0046879 25 16 0,000 0,10356677 0,13979083 ! bone remodeling GO:0046849 24 16 0,000 0,10356677 0,13970884 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,10356677 0,13962695 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10356677 0,13954515 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,10356677 0,13946345 ! glial cell development GO:0021782 24 16 0,000 0,10356677 0,13938185 ! patterning of blood vessels GO:0001569 24 16 0,000 0,10356677 0,13930034 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,10356677 0,13921892 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,10356677 0,1391376 ! protein polyubiquitination GO:0000209 26 16 0,000 0,10356677 0,13905638 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,10356677 0,13897525 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,10356677 0,13889421 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,10356677 0,13881327 ! fructose metabolic process GO:0006000 20 16 0,000 0,10356677 0,13873243 ! regulation of protein binding GO:0043393 27 16 0,000 0,10356677 0,13865167 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,10356677 0,13857102 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,10356677 0,13849045 ! protein export from nucleus GO:0006611 24 16 0,000 0,10356677 0,13840998 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,10356677 0,1383296 ! DNA replication initiation GO:0006270 25 16 0,000 0,10356677 0,13824932 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,10356677 0,13816913 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,10356677 0,13808903 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,10356677 0,13800902 ! diencephalon development GO:0021536 25 16 0,000 0,10356677 0,13792911 ! G1 phase GO:0051318 27 16 0,000 0,10356677 0,13784929 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,10356677 0,13776956 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,10356677 0,13768993 ! steroid catabolic process GO:0006706 22 16 0,000 0,10356677 0,13761038 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,10356677 0,13753093 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,10356677 0,13745157 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,10356677 0,1373723 ! sperm-egg recognition GO:0035036 16 16 0,000 0,10356677 0,13729313 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,10356677 0,13721404 ! nerve development GO:0021675 18 16 0,000 0,10356677 0,13713505 ! negative regulation of translation GO:0017148 22 16 0,000 0,10356677 0,13705614 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,10533502 0,13931602 ! regulation of neurological system process GO:0031644 122 81 1,000 0,10533502 0,13923595 ! vitamin metabolic process GO:0006766 103 81 1,000 0,10533502 0,13915598 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,10967438 0,14480544 ! negative regulation of defense response GO:0031348 19 17 0,000 0,10967438 0,14472237 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,10967438 0,14463938 ! glycerol metabolic process GO:0006071 20 17 0,000 0,10967438 0,14455649 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,10967438 0,1444737 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,10967438 0,144391 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,10967438 0,1443084 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,10967438 0,14422589 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,10967438 0,14414348 ! memory GO:0007613 25 17 0,000 0,10967438 0,14406116 ! keratinization GO:0031424 17 17 0,000 0,10967438 0,14397893 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,10967438 0,1438968 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,10967438 0,14381476 ! regulation of viral genome replication GO:0045069 24 17 0,000 0,10967438 0,14373281 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,10967438 0,14365096 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,10967438 0,1435692 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,10967438 0,14348753 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,10967438 0,14340596 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,10967438 0,14332448 ! membrane budding GO:0006900 29 17 0,000 0,10967438 0,14324309 ! heme metabolic process GO:0042168 27 17 0,000 0,10967438 0,1431618 ! body fluid secretion GO:0007589 27 17 0,000 0,10967438 0,14308059 ! stem cell differentiation GO:0048863 36 17 0,000 0,10967438 0,14299948 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,10967438 0,14291846 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,10967438 0,14283753 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,10967438 0,1427567 ! sensory perception of pain GO:0019233 23 17 0,000 0,10967438 0,14267595 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,10967438 0,1425953 ! synaptogenesis GO:0007416 24 17 0,000 0,10967438 0,14251474 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,10967438 0,14243427 GO:0046467|membrane lipid biosynthetic process, ! cell-cell junction organization GO:0045216 25 17 0,000 0,10967438 0,14235388 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,10967438 0,14227359 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,10967438 0,1421934 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,10967438 0,14211329 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,10967438 0,14203327 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,10969139 0,14197534 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,11188735 0,14473617 ! rRNA metabolic process GO:0016072 107 85 1,000 0,11409483 0,14750877 GO:0006364|rRNA processing, ! regulation of membrane potential GO:0042391 128 85 1,000 0,11409483 0,1474259 ! positive regulation of translation GO:0045727 28 18 0,000 0,11574073 0,14946866 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,11574073 0,14938478 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,11574073 0,149301 ! cAMP metabolic process GO:0046058 33 18 0,000 0,11574073 0,14921731 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,11574073 0,14913372 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,11574073 0,14905021 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,11574073 0,14896681 ! axis specification GO:0009798 26 18 0,000 0,11574073 0,14888349 ! pancreas development GO:0031016 26 18 0,000 0,11574073 0,14880027 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,11574073 0,14871714 ! glutamine metabolic process GO:0006541 23 18 0,000 0,11574073 0,1486341 ! pigmentation during development GO:0048066 31 18 0,000 0,11574073 0,14855116 ! central nervous system neuron development GO:0021954 30 18 0,000 0,11574073 0,14846831 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,11574073 0,14838555 ! fucose metabolic process GO:0006004 26 18 0,000 0,11574073 0,14830289 ! response to fungus GO:0009620 19 18 0,000 0,11574073 0,14822031 ! peptide cross-linking GO:0018149 31 18 0,000 0,11574073 0,14813783 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,11574073 0,14805544 ! heart process GO:0003015 27 18 0,000 0,11574073 0,14797314 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,11574073 0,14789093 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,11574073 0,14780882 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,11574073 0,14772679 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,11574073 0,14764486 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,11574073 0,14756302 ! hormone transport GO:0009914 27 18 0,000 0,11574073 0,14748126 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,11574073 0,1473996 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,11574073 0,14731803 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,11574073 0,14723655 ! cell-cell recognition GO:0009988 20 18 0,000 0,11574073 0,14715516 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,11574073 0,14707386 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,11574073 0,14699265 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,11574073 0,14691152 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,11631356 0,1475572 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,1185433 0,15030297 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,12176609 0,15430414 ! positive regulation of ossification GO:0045778 30 19 0,000 0,12176609 0,15421917 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,12176609 0,15413429 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,12176609 0,15404951 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,12176609 0,15396482 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,12176609 0,15388022 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,12176609 0,15379572 ! regeneration GO:0031099 32 19 0,000 0,12176609 0,15371131 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,12176609 0,15362699 ! response to alkaloid GO:0043279 32 19 0,000 0,12176609 0,15354277 ! sensory perception of taste GO:0050909 23 19 0,000 0,12176609 0,15345863 ! smooth muscle contraction GO:0006939 36 19 0,000 0,12176609 0,15337459 ! peroxisome organization GO:0007031 29 19 0,000 0,12176609 0,15329064 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,12176609 0,15320679 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,12176609 0,15312302 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,12176609 0,15303935 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,12176609 0,15295576 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,12176609 0,15287227 ! plasma membrane fusion GO:0045026 23 19 0,000 0,12176609 0,15278887 ! cytolysis GO:0019835 20 19 0,000 0,12176609 0,15270556 ! vasodilation GO:0042311 33 19 0,000 0,12176609 0,15262235 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,12176609 0,15253922 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,12176609 0,15245618 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,12176609 0,15237323 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,12176609 0,15229038 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,12176609 0,15220761 ! sarcomere organization GO:0045214 23 19 0,000 0,12176609 0,15212493 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,12176609 0,15204235 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,12176609 0,15195985 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,12176609 0,15187744 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,12176609 0,15179512 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,12176609 0,1517129 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,12176609 0,15163076 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,1230348 0,15312773 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,1230348 0,15304491 ! hormone metabolic process GO:0042445 121 90 1,000 0,12529607 0,15577349 ! response to virus GO:0009615 122 91 1,000 0,12756736 0,15851158 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,12775073 0,15865372 ! iron ion transport GO:0006826 37 20 0,000 0,12775073 0,1585681 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,12775073 0,15848257 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,12775073 0,15839714 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,12775073 0,15831179 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,12775073 0,15822654 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,12775073 0,15814138 ! spinal cord development GO:0021510 31 20 0,000 0,12775073 0,15805631 ! response to ethanol GO:0045471 37 20 0,000 0,12775073 0,15797134 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,12775073 0,15788645 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,12775073 0,15780166 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,12775073 0,15771695 ! chromosome condensation GO:0030261 31 20 0,000 0,12775073 0,15763234 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,12775073 0,15754782 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,12775073 0,15746339 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,12775073 0,15737905 ! pallium development GO:0021543 38 20 0,000 0,12775073 0,1572948 ! DNA modification GO:0006304 28 20 0,000 0,12775073 0,15721064 ! collagen fibril organization GO:0030199 45 20 0,000 0,12775073 0,15712657 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,12775073 0,15704259 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,12775073 0,1569587 ! collagen catabolic process GO:0030574 25 20 0,000 0,12775073 0,1568749 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,12775073 0,15679119 ! alditol metabolic process GO:0019400 24 20 0,000 0,12775073 0,15670757 ! actin filament-based movement GO:0030048 34 20 0,000 0,12775073 0,15662403 ! cell fate commitment GO:0045165 141 92 1,000 0,12984844 0,15911104 ! positive regulation of immune response GO:0050778 121 92 1,000 0,12984844 0,15902631 ! DNA recombination GO:0006310 146 92 1,000 0,12984844 0,15894168 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,13369494 0,16356295 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,13369494 0,163476 GO:0016444|somatic cell DNA recombination, ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,13369494 0,16338913 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13369494 0,16330236 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13369494 0,16321569 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,13369494 0,1631291 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,13369494 0,1630426 ! vesicle docking GO:0048278 27 21 0,000 0,13369494 0,1629562 ! phototransduction GO:0007602 25 21 0,000 0,13369494 0,16286989 ! dendrite development GO:0016358 35 21 0,000 0,13369494 0,16278367 ! visual behavior GO:0007632 39 21 0,000 0,13369494 0,16269754 ! ovarian follicle development GO:0001541 30 21 0,000 0,13369494 0,1626115 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13369494 0,16252556 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,13369494 0,1624397 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,13369494 0,16235393 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,13369494 0,16226826 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13369494 0,16218267 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,13369494 0,16209718 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13369494 0,16201178 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13369494 0,16192646 ! fatty acid transport GO:0015908 30 21 0,000 0,13369494 0,16184124 ! platelet activation GO:0030168 28 21 0,000 0,13369494 0,1617561 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13369494 0,16167106 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,13369494 0,1615861 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,13369494 0,16150124 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13369494 0,16141646 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,13369494 0,16133177 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13369494 0,16124717 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13369494 0,16116266 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,13369494 0,16107824 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,13369494 0,1609939 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,13369494 0,16090966 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13369494 0,1608255 ! carboxylic acid transport GO:0046942 147 95 1,000 0,13674806 0,1644122 GO:0015849|organic acid transport, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,13959897 0,16775216 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,13959897 0,16766456 ! viral genome replication GO:0019079 29 22 0,000 0,13959897 0,16757705 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,13959897 0,16748963 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,13959897 0,16740231 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,13959897 0,16731507 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,13959897 0,16722793 ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,13959897 0,16714088 ! lysosome organization GO:0007040 37 22 0,000 0,13959897 0,16705392 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,13959897 0,16696704 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,13959897 0,16688026 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,13959897 0,16679357 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,13959897 0,16670697 ! membrane depolarization GO:0051899 35 22 0,000 0,13959897 0,16662046 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,13959897 0,16653404 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,13959897 0,16644771 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,13959897 0,16636146 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,13959897 0,16627531 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,13959897 0,16618925 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,14139249 0,16823732 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,1454631 0,17299127 ! neuron fate commitment GO:0048663 32 23 0,000 0,1454631 0,17290187 ! embryonic pattern specification GO:0009880 31 23 0,000 0,1454631 0,17281256 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,1454631 0,17272335 ! vesicle targeting GO:0006903 32 23 0,000 0,1454631 0,17263422 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,1454631 0,17254519 ! osteoblast differentiation GO:0001649 40 23 0,000 0,1454631 0,17245625 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,1454631 0,1723674 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,1454631 0,17227864 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,1454631 0,17218998 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,1454631 0,1721014 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,1454631 0,17201292 ! cell fate determination GO:0001709 45 23 0,000 0,1454631 0,17192453 ! pentose metabolic process GO:0019321 31 23 0,000 0,1454631 0,17183622 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,1454631 0,17174801 ! spermatid development GO:0007286 33 23 0,000 0,1454631 0,17165989 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,1454631 0,17157186 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,1454631 0,17148392 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,1454631 0,17139607 ! telomere organization GO:0032200 32 23 0,000 0,1454631 0,17130831 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,1454631 0,17122064 ! regulation of amine transport GO:0051952 38 23 0,000 0,1454631 0,17113306 ! liver development GO:0001889 40 23 0,000 0,1454631 0,17104557 ! calcium ion transport GO:0006816 167 99 1,000 0,14607059 0,17167213 ! extracellular structure organization GO:0043062 156 99 1,000 0,14607059 0,17158445 ! regulation of translation GO:0006417 151 100 1,000 0,14842171 0,17425724 ! divalent metal ion transport GO:0070838 171 100 1,000 0,14842171 0,17416833 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,14842171 0,17407952 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,1512876 0,17735039 ! initiation of viral infection GO:0019059 42 24 0,000 0,1512876 0,17726005 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,1512876 0,17716979 ! superoxide metabolic process GO:0006801 32 24 0,000 0,1512876 0,17707963 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,1512876 0,17698956 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,1512876 0,17689958 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,1512876 0,17680969 ! sperm motility GO:0030317 27 24 0,000 0,1512876 0,17671989 ! vacuole organization GO:0007033 39 24 0,000 0,1512876 0,17663019 ! response to toxin GO:0009636 38 24 0,000 0,1512876 0,17654057 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,1512876 0,17645105 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,1512876 0,17636162 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,1512876 0,17627227 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,15707272 0,18292013 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,15707272 0,18282756 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,15707272 0,18273509 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,15707272 0,1826427 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,15707272 0,18255041 ! peptide transport GO:0015833 43 25 0,000 0,15707272 0,18245821 ! male gonad development GO:0008584 33 25 0,000 0,15707272 0,18236611 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,15707272 0,1822741 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,15707272 0,18218218 ! phospholipid transport GO:0015914 35 25 0,000 0,15707272 0,18209036 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,15707272 0,18199862 ! detection of light stimulus GO:0009583 30 25 0,000 0,15707272 0,18190698 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,15707272 0,18181543 GO:0045840|positive regulation of mitosis, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,16281875 0,18837179 ! translational initiation GO:0006413 43 26 0,000 0,16281875 0,18827708 ! circadian rhythm GO:0007623 42 26 0,000 0,16281875 0,18818247 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,16281875 0,18808796 ! post-embryonic development GO:0009791 42 26 0,000 0,16281875 0,18799353 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,16281875 0,18789921 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,16281875 0,18780498 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,16281875 0,18771084 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,16281875 0,18761679 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,16281875 0,18752284 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,16281875 0,18742899 ! regulation of coagulation GO:0050818 39 26 0,000 0,16281875 0,18733523 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,16852593 0,19380482 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,16852593 0,19370797 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,16852593 0,19361121 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,16852593 0,19351455 ! membrane docking GO:0022406 39 27 0,000 0,16852593 0,19341798 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,16852593 0,19332152 ! catechol metabolic process GO:0009712 43 27 0,000 0,16852593 0,19322514 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,16852593 0,19312887 ! acute-phase response GO:0006953 42 27 0,000 0,16852593 0,19303269 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,16852593 0,1929366 ! myofibril assembly GO:0030239 36 27 0,000 0,16852593 0,19284062 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,16852593 0,19274472 ! natural killer cell activation GO:0030101 35 27 0,000 0,16852593 0,19264893 ! lipid oxidation GO:0034440 38 27 0,000 0,16852593 0,19255322 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,16852593 0,19245762 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,16852593 0,1923621 ! gene silencing GO:0016458 41 27 0,000 0,16852593 0,19226669 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,17419453 0,19863531 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,17419453 0,19853688 ! phenol metabolic process GO:0018958 44 28 0,000 0,17419453 0,19843854 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,17419453 0,19834031 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,17419453 0,19824217 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,17419453 0,19814412 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,17419453 0,19804618 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,17419453 0,19794833 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,17419453 0,19785058 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,17419453 0,19775292 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,17419453 0,19765536 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,17419453 0,1975579 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,17419453 0,19746053 ! mesoderm formation GO:0001707 46 28 0,000 0,17419453 0,19736326 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,17419453 0,19726609 ! BMP signaling pathway GO:0030509 40 28 0,000 0,17419453 0,19716901 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,17419453 0,19707202 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,17419453 0,19697513 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,17982481 0,2032418 ! regulation of innate immune response GO:0045088 38 29 0,000 0,17982481 0,20314197 ! ovulation cycle process GO:0022602 41 29 0,000 0,17982481 0,20304225 ! protein targeting to membrane GO:0006612 53 29 0,000 0,17982481 0,20294262 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,17982481 0,20284309 ! mismatch repair GO:0006298 34 29 0,000 0,17982481 0,20274365 ! muscle cell development GO:0055001 38 29 0,000 0,17982481 0,20264432 ! formation of primary germ layer GO:0001704 48 29 0,000 0,17982481 0,20254508 ! telencephalon development GO:0021537 52 29 0,000 0,17982481 0,20244594 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,17982481 0,2023469 ! organic anion transport GO:0015711 51 30 0,000 0,18541702 0,20853748 ! cholesterol transport GO:0030301 46 30 0,000 0,18541702 0,20843555 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,18541702 0,20833373 ! spindle organization GO:0007051 37 30 0,000 0,18541702 0,208232 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,18541702 0,20813038 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,18541702 0,20802885 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,18541702 0,20792742 ! ceramide metabolic process GO:0006672 43 30 0,000 0,18541702 0,20782609 ! ovulation cycle GO:0042698 43 30 0,000 0,18541702 0,20772486 ! hindbrain development GO:0030902 45 30 0,000 0,18541702 0,20762373 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,18541702 0,2075227 ! adult locomotory behavior GO:0008344 47 30 0,000 0,18541702 0,20742176 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,18541702 0,20732092 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,18541702 0,20722018 ! negative regulation of secretion GO:0051048 49 31 0,000 0,19097142 0,21332407 ! glial cell differentiation GO:0010001 55 31 0,000 0,19097142 0,21322051 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,19097142 0,21311706 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,19097142 0,2130137 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,19097142 0,21291045 ! odontogenesis GO:0042476 50 31 0,000 0,19097142 0,2128073 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,19097142 0,21270424 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,19097142 0,21260129 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,19097142 0,21249843 ! cell fate specification GO:0001708 37 31 0,000 0,19097142 0,21239568 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,19097142 0,21229302 ! RNA modification GO:0009451 40 31 0,000 0,19097142 0,21219046 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,19648826 0,21821487 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,19648826 0,21810955 ! meiosis I GO:0007127 52 32 0,000 0,19648826 0,21800434 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,19648826 0,21789923 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 44 32 0,000 0,19648826 0,21779421 ! vesicle localization GO:0051648 47 32 0,000 0,19648826 0,2176893 ! RNA export from nucleus GO:0006405 44 33 0,000 0,20196779 0,22365235 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,20196779 0,22354472 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,20196779 0,22343719 ! sister chromatid segregation GO:0000819 46 33 0,000 0,20196779 0,22332977 ! ear morphogenesis GO:0042471 42 33 0,000 0,20196779 0,22322245 ! actomyosin structure organization GO:0031032 43 33 0,000 0,20196779 0,22311524 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,20196779 0,22300813 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,20196779 0,22290112 ! positive regulation of cell development GO:0010720 54 33 0,000 0,20196779 0,22279421 ! lipid homeostasis GO:0055088 55 33 0,000 0,20196779 0,2226874 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,20196779 0,2225807 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,20196779 0,2224741 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,20196779 0,2223676 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,20196779 0,22226121 ! mRNA catabolic process GO:0006402 48 34 0,000 0,20741027 0,22814138 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,20741027 0,22803233 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,20741027 0,22792338 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,20741027 0,22781453 ! feeding behavior GO:0007631 45 34 0,000 0,20741027 0,22770579 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,20741027 0,22759715 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,20741027 0,22748862 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,20741027 0,22738019 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,20741027 0,22727186 ! aerobic respiration GO:0009060 47 34 0,000 0,20741027 0,22716363 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,20741027 0,22705551 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,20741027 0,22694749 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,21281595 0,23275163 ! Notch signaling pathway GO:0007219 56 35 0,000 0,21281595 0,23264101 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,21281595 0,23253049 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,21281595 0,23242007 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,21281595 0,23230977 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,21281595 0,23219956 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,21281595 0,23208946 ! pigment metabolic process GO:0042440 61 35 0,000 0,21281595 0,23197947 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,21818506 0,23771939 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,21818506 0,23760683 ! organic ether metabolic process GO:0018904 46 36 0,000 0,21818506 0,23749438 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,21818506 0,23738204 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,21818506 0,2372698 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,22351786 0,24295419 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,22351786 0,24283943 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,22351786 0,24272477 ! ion transmembrane transport GO:0034220 56 37 0,000 0,22351786 0,24261023 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,22351786 0,24249579 ! amino acid activation GO:0043038 52 37 0,000 0,22351786 0,24238146 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,22351786 0,24226723 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,22881458 0,24789144 ! gliogenesis GO:0042063 71 38 0,000 0,22881458 0,24777473 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,22881458 0,24765813 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,22881458 0,24754164 ! phagocytosis GO:0006909 60 38 0,000 0,22881458 0,24742526 ! pigmentation GO:0043473 74 38 0,000 0,22881458 0,24730899 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,23407548 0,25287628 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,23407548 0,25275756 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,23407548 0,25263895 ! male sex differentiation GO:0046661 53 39 0,000 0,23407548 0,25252045 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,23407548 0,25240206 ! JNK cascade GO:0007254 54 39 0,000 0,23407548 0,25228378 ! cell growth GO:0016049 61 39 0,000 0,23407548 0,25216562 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,23930078 0,25767406 ! response to calcium ion GO:0051592 58 40 0,000 0,23930078 0,25755349 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,23930078 0,25743302 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,23930078 0,25731267 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,23930078 0,25719243 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,23930078 0,2570723 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,23930078 0,25695229 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,23930078 0,25683239 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,24449074 0,26228018 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,24449074 0,2621579 ! striated muscle contraction GO:0006941 62 41 0,000 0,24449074 0,26203574 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,24449074 0,26191369 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,24964558 0,26731138 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,24964558 0,26718699 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,24964558 0,26706271 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,24964558 0,26693856 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,24964558 0,26681452 ! excretion GO:0007588 63 42 0,000 0,24964558 0,26669059 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,24964558 0,26656678 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,24964558 0,26644308 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,24964558 0,2663195 ! neuromuscular process GO:0050905 79 43 0,000 0,25476555 0,27165543 ! tRNA processing GO:0008033 49 43 0,000 0,25476555 0,27152954 ! vesicle organization GO:0016050 79 43 0,000 0,25476555 0,27140378 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,25985087 0,27669305 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,25985087 0,27656501 ! glycolysis GO:0006096 53 44 0,000 0,25985087 0,27643709 ! regulation of ion transport GO:0043269 57 44 0,000 0,25985087 0,27630929 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,25985087 0,2761816 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,25985087 0,27605404 ! RNA catabolic process GO:0006401 64 45 0,000 0,26490177 0,28128997 ! regulation of translational initiation GO:0006446 64 45 0,000 0,26490177 0,28116017 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,26490177 0,28103048 ! cell recognition GO:0008037 58 45 0,000 0,26490177 0,28090091 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,2699185 0,28608874 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,2699185 0,28595696 ! cell redox homeostasis GO:0045454 63 46 0,000 0,2699185 0,2858253 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,2699185 0,28569377 ! regulation of ossification GO:0030278 71 46 0,000 0,2699185 0,28556235 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,27490128 0,2907002 ! viral infectious cycle GO:0019058 71 47 0,000 0,27490128 0,29056661 ! endocrine system development GO:0035270 83 47 0,000 0,27490128 0,29043314 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,27490128 0,29029979 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,27490128 0,29016656 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,27490128 0,29003346 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,27490128 0,28990048 ! chloride transport GO:0006821 67 48 0,000 0,27985033 0,29498431 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,27985033 0,29484918 ! gastrulation GO:0007369 73 48 0,000 0,27985033 0,29471418 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,27985033 0,2945793 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,27985033 0,29444454 ! regulation of endocytosis GO:0030100 63 48 0,000 0,27985033 0,29430991 ! nuclear export GO:0051168 69 48 0,000 0,27985033 0,2941754 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,28476589 0,29920582 ! sensory perception of smell GO:0007608 61 49 0,000 0,28476589 0,2990692 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,28476589 0,2989327 ! RNA elongation GO:0006354 62 49 0,000 0,28476589 0,29879633 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,28476589 0,29866008 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,28476589 0,29852395 ! regulation of actin filament length GO:0030832 72 50 0,000 0,28964817 0,30350378 ! membrane fusion GO:0006944 80 50 0,000 0,28964817 0,30336557 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,28964817 0,30322749 ! proton transport GO:0015992 75 50 0,000 0,28964817 0,30308954 ! hydrogen transport GO:0006818 77 51 0,000 0,29449741 0,30802367 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,29449741 0,30788365 ! adult behavior GO:0030534 80 51 0,000 0,29449741 0,30774377 ! transition metal ion transport GO:0000041 74 52 0,000 0,29931382 0,31263478 ! regulation of cellular component size GO:0032535 74 52 0,000 0,29931382 0,31249286 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,29931382 0,31235108 ! establishment of organelle localization GO:0051656 85 52 0,000 0,29931382 0,31220942 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,30409762 0,31705554 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,30409762 0,31691188 ! single fertilization GO:0007338 59 53 0,000 0,30409762 0,31676835 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,30884903 0,3215721 ! regulation of mitosis GO:0007088 84 54 0,000 0,30884903 0,32142659 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,30884903 0,32128122 ! detection of external stimulus GO:0009581 66 54 0,000 0,30884903 0,32113597 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,30884903 0,32099086 ! exocytosis GO:0006887 74 55 0,000 0,31356827 0,32574843 ! mesoderm development GO:0007498 76 55 0,000 0,31356827 0,32560137 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,31356827 0,32545444 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,31356827 0,32530764 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,31825556 0,33002155 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,32291111 0,33469831 GO:0048609|reproductive process in a multicellular organism, ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,32291111 0,33454755 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,32753513 0,33918541 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,32753513 0,33903277 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,32753513 0,33888025 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,33212784 0,34347753 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,33212784 0,34332316 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,33668944 0,34788217 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,33668944 0,34772596 ! fertilization GO:0009566 68 60 0,000 0,33668944 0,34756989 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,34122015 0,35208898 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,34122015 0,35193109 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,34122015 0,35177335 ! extracellular matrix organization GO:0030198 103 61 0,000 0,34122015 0,35161574 ! amine catabolic process GO:0009310 90 62 0,000 0,34572016 0,35609332 ! neurotransmitter transport GO:0006836 81 62 0,000 0,34572016 0,35593392 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,34572016 0,35577467 ! organelle localization GO:0051640 96 62 0,000 0,34572016 0,35561555 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,3501897 0,36005199 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,35462896 0,36445335 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,35462896 0,36429058 ! hexose catabolic process GO:0019320 82 64 0,000 0,35462896 0,36412795 ! defense response to bacterium GO:0042742 73 65 0,000 0,35903814 0,36849073 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,36341745 0,37281897 ! antigen processing and presentation GO:0019882 96 66 0,000 0,36341745 0,37265276 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,36341745 0,37248669 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,36776709 0,37677697 ! acute inflammatory response GO:0002526 92 68 0,000 0,37208726 0,38103326 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,37208726 0,38086368 ! rhythmic process GO:0048511 105 68 0,000 0,37208726 0,38069426 ! inorganic anion transport GO:0015698 93 68 0,000 0,37208726 0,38052499 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,37637815 0,38474211 ! response to metal ion GO:0010038 103 70 0,000 0,38063997 0,38892578 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,38063997 0,38875307 ! humoral immune response GO:0006959 86 70 0,000 0,38063997 0,38858053 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,38063997 0,38840813 ! muscle cell differentiation GO:0042692 104 71 0,000 0,3848729 0,39255329 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,3848729 0,39237929 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,3848729 0,39220544 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,3848729 0,39203174 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,38907715 0,39613875 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,3932529 0,40021313 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,39740034 0,40425511 ! blood coagulation GO:0007596 116 75 0,000 0,40151968 0,40826492 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,40151968 0,40808452 ! tRNA metabolic process GO:0006399 95 76 0,000 0,40561109 0,41206073 ! response to unfolded protein GO:0006986 99 76 0,000 0,40561109 0,41187881 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,40967476 0,41582169 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,41371088 0,41973314 ! cellular respiration GO:0045333 107 79 0,000 0,41771964 0,42361339 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,41771964 0,42342669 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,41771964 0,42324016 ! chromatin assembly GO:0031497 102 80 0,000 0,42170121 0,42708621 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,42170121 0,42689824 ! forebrain development GO:0030900 131 80 0,000 0,42170121 0,42671042 ! hemostasis GO:0007599 125 81 0,000 0,42565579 0,43052257 ! mRNA transport GO:0051028 121 81 0,000 0,42565579 0,43033333 ! response to protein stimulus GO:0051789 111 81 0,000 0,42565579 0,43014425 ! detection of stimulus GO:0051606 108 82 0,000 0,42958355 0,43392278 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,43348468 0,4376711 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,43735934 0,44138942 ! sterol metabolic process GO:0016125 120 84 0,000 0,43735934 0,44119583 ! transcription initiation GO:0006352 118 85 0,000 0,44120773 0,44488285 ! nucleosome organization GO:0034728 114 87 0,000 0,44882637 0,45236663 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,44882637 0,45216849 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,44882637 0,45197051 ! female pregnancy GO:0007565 130 87 0,000 0,44882637 0,45177272 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,45259698 0,45536879 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,45259698 0,45516967 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,45259698 0,45497074 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,45259698 0,45477197 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,456342 0,45833476 ! RNA localization GO:0006403 135 91 0,000 0,463756 0,46557782 ! ATP metabolic process GO:0046034 137 91 0,000 0,463756 0,46537469 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,47106973 0,47250779 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,47106973 0,47230182 ! electron transport chain GO:0022900 123 94 0,000 0,47468941 0,47572359 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,48185526 0,48269472 ! protein maturation GO:0051604 129 96 0,000 0,48185526 0,48248458 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,48540174 0,4858242 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,49589742 0,49611312 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,49589742 0,49589742