pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6808-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! branched chain family amino acid metabolic process GO:0009081 37 17 3,000 1,931E-07 4,717E-04 ! response to nutrient GO:0007584 135 84 5,000 2,422E-07 2,959E-04 ! positive regulation of glycolysis GO:0045821 13 5 2,000 2,793E-07 2,274E-04 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 3,000 4,81E-07 2,938E-04 ! nuclear migration GO:0007097 13 6 2,000 5,573E-07 2,723E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 5,573E-07 2,269E-04 GO:0031272|regulation of pseudopodium assembly, ! regulation of oxidoreductase activity GO:0051341 48 24 3,000 8,48E-07 2,959E-04 ! positive regulation of cell migration GO:0030335 137 58 4,000 9,953E-07 3,039E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 1,187E-06 3,223E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 1,391E-06 3,397E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 1,553E-06 3,45E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 1,553E-06 3,163E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 1,553E-06 2,919E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 1,619E-06 2,824E-04 ! positive regulation of cell motion GO:0051272 157 65 4,000 1,764E-06 2,873E-04 ! positive regulation of glucose metabolic process GO:0010907 18 9 2,000 2,325E-06 3,55E-04 ! regulation of glycolysis GO:0006110 20 9 2,000 2,325E-06 3,341E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,325E-06 3,156E-04 ! macrophage differentiation GO:0030225 15 9 2,000 2,325E-06 2,989E-04 ! branched chain family amino acid catabolic process GO:0009083 19 9 2,000 2,325E-06 2,84E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 2,000 3,314E-06 3,855E-04 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 3,314E-06 3,68E-04 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 2,000 4,547E-06 4,829E-04 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 4,547E-06 4,628E-04 ! nucleus localization GO:0051647 22 11 2,000 4,547E-06 4,443E-04 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 3,000 5,111E-06 4,802E-04 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! cellular response to insulin stimulus GO:0032869 85 38 3,000 5,699E-06 5,156E-04 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 6,048E-06 5,277E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 6,048E-06 5,095E-04 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 6,672E-06 5,433E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 2,000 7,845E-06 6,183E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 2,000 7,845E-06 5,99E-04 ! ossification GO:0001503 205 91 4,000 9,322E-06 6,901E-04 ! bone development GO:0060348 206 92 4,000 9,834E-06 7,066E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 1,236E-05 8,63E-04 ! response to cAMP GO:0051591 25 15 2,000 1,243E-05 8,432E-04 ! positive regulation of oxidoreductase activity GO:0051353 22 15 2,000 1,243E-05 8,204E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 1,338E-05 8,604E-04 ! response to insulin stimulus GO:0032868 98 47 3,000 1,348E-05 8,445E-04 ! regulation of glucose metabolic process GO:0010906 28 16 2,000 1,526E-05 9,319E-04 ! filopodium assembly GO:0046847 42 17 2,000 1,849E-05 1,102E-03 ! response to retinoic acid GO:0032526 31 18 2,000 2,214E-05 1,288E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 2,214E-05 1,258E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 2,214E-05 1,229E-03 ! microspike assembly GO:0030035 46 18 2,000 2,214E-05 1,202E-03 ! regulation of angiogenesis GO:0045765 125 54 3,000 2,351E-05 1,249E-03 ! response to vitamin A GO:0033189 32 19 2,000 2,623E-05 1,363E-03 ! response to vitamin GO:0033273 36 20 2,000 3,079E-05 1,567E-03 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 3,079E-05 1,535E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! establishment of organelle localization GO:0051656 122 59 3,000 3,344E-05 1,634E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 3,584E-05 1,717E-03 ! response to glucocorticoid stimulus GO:0051384 42 22 2,000 4,14E-05 1,945E-03 ! regulation of protein complex assembly GO:0043254 132 63 3,000 4,336E-05 1,998E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 4,614E-05 2,087E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 4,614E-05 2,049E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 5,417E-05 2,363E-03 ! response to corticosteroid stimulus GO:0031960 46 24 2,000 5,417E-05 2,322E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 6,142E-05 2,587E-03 ! vasculogenesis GO:0001570 49 25 2,000 6,142E-05 2,543E-03 ! interaction with host GO:0051701 66 25 2,000 6,142E-05 2,501E-03 ! osteoblast differentiation GO:0001649 63 26 2,000 6,928E-05 2,775E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 7,777E-05 3,064E-03 ! acetyl-CoA metabolic process GO:0006084 41 27 2,000 7,777E-05 3,016E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 7,777E-05 2,968E-03 ! organelle localization GO:0051640 155 74 3,000 8,161E-05 3,067E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 8,69E-05 3,217E-03 ! cell-matrix adhesion GO:0007160 181 76 3,000 9,057E-05 3,302E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 9,262E-05 3,328E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 9,262E-05 3,279E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 9,262E-05 3,232E-03 ! valine metabolic process GO:0006573 12 5 1,000 9,262E-05 3,187E-03 ! mRNA transcription GO:0009299 10 5 1,000 9,262E-05 3,143E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 9,262E-05 3,1E-03 ! peptidyl-histidine phosphorylation GO:0018106 10 5 1,000 9,262E-05 3,058E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 9,262E-05 3,017E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! meiotic chromosome segregation GO:0045132 10 5 1,000 9,262E-05 2,977E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 9,262E-05 2,939E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 9,262E-05 2,901E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 9,262E-05 2,864E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 1,072E-04 3,274E-03 ! response to hypoxia GO:0001666 178 81 3,000 1,161E-04 3,501E-03 ! cell junction assembly GO:0034329 85 31 2,000 1,184E-04 3,529E-03 ! cell-substrate adhesion GO:0031589 189 82 3,000 1,217E-04 3,583E-03 ! regulation of adenylate cyclase activity GO:0045761 165 83 3,000 1,276E-04 3,711E-03 ! response to oxygen levels GO:0070482 183 83 3,000 1,276E-04 3,667E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,304E-04 3,704E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 1,387E-04 3,893E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 1,387E-04 3,849E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 1,387E-04 3,806E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 1,387E-04 3,764E-03 GO:0051653|spindle localization, ! oxygen homeostasis GO:0032364 10 6 1,000 1,387E-04 3,722E-03 ! regulation of cyclase activity GO:0031279 168 85 3,000 1,399E-04 3,716E-03 ! regulation of cAMP biosynthetic process GO:0030817 173 86 3,000 1,464E-04 3,846E-03 ! regulation of lyase activity GO:0051339 169 86 3,000 1,464E-04 3,805E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 1,566E-04 4,028E-03 ! regulation of cAMP metabolic process GO:0030814 182 89 3,000 1,672E-04 4,254E-03 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 3,000 1,821E-04 4,587E-03 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,937E-04 4,829E-03 ! mRNA stabilization GO:0048255 18 7 1,000 1,937E-04 4,781E-03 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 1,937E-04 4,733E-03 ! male sex determination GO:0030238 15 7 1,000 1,937E-04 4,686E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 1,937E-04 4,64E-03 ! peptidyl-histidine modification GO:0018202 17 7 1,000 1,937E-04 4,595E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 1,98E-04 4,652E-03 ! cell junction organization GO:0034330 96 37 2,000 2,02E-04 4,7E-03 ! tissue remodeling GO:0048771 78 37 2,000 2,02E-04 4,656E-03 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 3,000 2,149E-04 4,907E-03 ! carbohydrate homeostasis GO:0033500 59 39 2,000 2,366E-04 5,351E-03 GO:0042593|glucose homeostasis, ! regulation of nucleotide metabolic process GO:0006140 197 98 3,000 2,421E-04 5,427E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 2,578E-04 5,725E-03 ! succinate metabolic process GO:0006105 17 8 1,000 2,578E-04 5,674E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 2,578E-04 5,623E-03 ! hemoglobin metabolic process GO:0020027 14 8 1,000 2,578E-04 5,573E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 2,578E-04 5,524E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,578E-04 5,476E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 2,578E-04 5,429E-03 ! gas homeostasis GO:0033483 14 8 1,000 2,578E-04 5,383E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 2,578E-04 5,337E-03 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 2,578E-04 5,292E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 2,747E-04 5,592E-03 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 2,747E-04 5,546E-03 ! cytokinesis GO:0000910 84 42 2,000 2,952E-04 5,911E-03 ! neuron migration GO:0001764 85 43 2,000 3,166E-04 6,288E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 3,308E-04 6,517E-03 ! S phase GO:0051320 10 9 1,000 3,308E-04 6,465E-03 GO:0000084|S phase of mitotic cell cycle, ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 3,624E-04 7,027E-03 ! glycolysis GO:0006096 71 46 2,000 3,868E-04 7,441E-03 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 3,868E-04 7,383E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 4,126E-04 7,815E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 4,126E-04 7,754E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 4,126E-04 7,695E-03 ! lung alveolus development GO:0048286 26 10 1,000 4,126E-04 7,637E-03 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 4,126E-04 7,579E-03 ! phosphagen metabolic process GO:0006599 17 10 1,000 4,126E-04 7,523E-03 GO:0006600|creatine metabolic process, ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 4,126E-04 7,467E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 4,126E-04 7,412E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 4,126E-04 7,358E-03 ! positive regulation of cell cycle GO:0045787 96 48 2,000 4,388E-04 7,768E-03 ! negative regulation of muscle development GO:0048635 27 11 1,000 5,033E-04 8,846E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 5,033E-04 8,783E-03 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 5,033E-04 8,721E-03 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 5,033E-04 8,659E-03 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 5,033E-04 8,599E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 5,033E-04 8,539E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 5,033E-04 8,48E-03 ! regulation of cell projection organization GO:0031344 135 51 2,000 5,248E-04 8,782E-03 ! positive regulation of growth GO:0045927 96 53 2,000 5,878E-04 9,768E-03 ! cartilage development GO:0051216 99 53 2,000 5,878E-04 9,702E-03 ! virus-host interaction GO:0019048 30 12 1,000 6,028E-04 9,883E-03 ! regulation of B cell proliferation GO:0030888 22 12 1,000 6,028E-04 9,817E-03 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 6,028E-04 9,752E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 37 12 1,000 6,028E-04 9,688E-03 ! entry into host cell GO:0030260 34 12 1,000 6,028E-04 9,625E-03 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 6,028E-04 9,562E-03 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 6,028E-04 9,501E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 6,028E-04 9,44E-03 ! regulation of leukocyte migration GO:0002685 29 12 1,000 6,028E-04 9,38E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 6,028E-04 9,32E-03 ! embryonic placenta development GO:0001892 21 12 1,000 6,028E-04 9,262E-03 ! localization within membrane GO:0051668 26 12 1,000 6,028E-04 9,204E-03 ! regulation of cell shape GO:0008360 142 54 2,000 6,209E-04 9,422E-03 ! response to UV GO:0009411 120 55 2,000 6,553E-04 9,882E-03 ! glucose catabolic process GO:0006007 88 56 2,000 6,909E-04 0,01035449 ! regulation of chemokine production GO:0032642 18 13 1,000 7,109E-04 0,01059053 ! cartilage condensation GO:0001502 22 13 1,000 7,109E-04 0,01052634 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 7,109E-04 0,01046293 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 7,109E-04 0,01040028 ! regulation of mRNA stability GO:0043488 32 13 1,000 7,109E-04 0,01033837 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 7,276E-04 0,01051828 ! heart morphogenesis GO:0003007 105 57 2,000 7,276E-04 0,01045641 ! cell-cell junction assembly GO:0007043 32 14 1,000 8,278E-04 0,01182611 ! regulation of RNA stability GO:0043487 33 14 1,000 8,278E-04 0,01175735 ! viral reproductive process GO:0022415 132 62 2,000 9,301E-04 0,01313425 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 9,301E-04 0,01305876 ! regulation of homeostatic process GO:0032844 148 62 2,000 9,301E-04 0,01298414 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 9,532E-04 0,01323132 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 9,532E-04 0,01315656 ! muscle maintenance GO:0046716 26 15 1,000 9,532E-04 0,01308265 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 9,532E-04 0,01300956 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,087E-03 0,01475589 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 1,115E-03 0,01505489 ! activation of MAPK activity GO:0000187 124 67 2,000 1,165E-03 0,01563922 ! myeloid cell differentiation GO:0030099 126 67 2,000 1,165E-03 0,01555376 ! hexose catabolic process GO:0019320 113 68 2,000 1,216E-03 0,01614729 ! viral reproduction GO:0016032 142 68 2,000 1,216E-03 0,01606001 ! cell projection assembly GO:0030031 138 68 2,000 1,216E-03 0,01597366 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 1,23E-03 0,01606513 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 1,23E-03 0,01597967 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 1,23E-03 0,01589512 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,23E-03 0,01581147 ! negative regulation of protein kinase activity GO:0006469 144 69 2,000 1,269E-03 0,0162265 ! lung development GO:0030324 165 69 2,000 1,269E-03 0,01614199 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 2,000 1,269E-03 0,01605835 ! cellular amino acid catabolic process GO:0009063 120 69 2,000 1,269E-03 0,01597558 ! negative regulation of kinase activity GO:0033673 145 70 2,000 1,322E-03 0,01656848 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 1,381E-03 0,01720888 ! heart looping GO:0001947 34 18 1,000 1,381E-03 0,01712153 ! cell-substrate junction assembly GO:0007044 56 18 1,000 1,381E-03 0,01703506 ! neural crest cell migration GO:0001755 41 18 1,000 1,381E-03 0,01694945 ! respiratory tube development GO:0030323 171 72 2,000 1,434E-03 0,01752234 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 1,54E-03 0,01871751 ! negative regulation of transferase activity GO:0051348 155 74 2,000 1,552E-03 0,01877334 ! respiratory system development GO:0060541 175 74 2,000 1,552E-03 0,01868086 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 1,708E-03 0,02045043 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 1,708E-03 0,02035067 ! protein amino acid acetylation GO:0006473 41 20 1,000 1,708E-03 0,02025188 ! forelimb morphogenesis GO:0035136 35 20 1,000 1,708E-03 0,02015405 ! actin filament bundle formation GO:0051017 47 20 1,000 1,708E-03 0,02005715 ! cell-cell junction organization GO:0045216 43 20 1,000 1,708E-03 0,01996118 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 1,708E-03 0,01986613 ! amine catabolic process GO:0009310 136 77 2,000 1,74E-03 0,02014646 ! monosaccharide catabolic process GO:0046365 125 77 2,000 1,74E-03 0,02005143 ! regulation of catabolic process GO:0009894 173 77 2,000 1,74E-03 0,01995729 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 1,873E-03 0,02137903 ! lipid phosphorylation GO:0046834 43 21 1,000 1,884E-03 0,0214038 ! plasma membrane fusion GO:0045026 33 21 1,000 1,884E-03 0,02130471 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 1,884E-03 0,02120653 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 2,012E-03 0,02254288 ! hindlimb morphogenesis GO:0035137 47 22 1,000 2,068E-03 0,02306797 ! positive regulation of locomotion GO:0040017 44 22 1,000 2,068E-03 0,02296311 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 42 22 1,000 2,068E-03 0,02285921 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 2,068E-03 0,02275624 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 2,157E-03 0,02362711 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of DNA replication GO:0045740 44 23 1,000 2,26E-03 0,02465162 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 2,26E-03 0,02454206 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 2,26E-03 0,02443347 ! regulation of chemotaxis GO:0050920 45 23 1,000 2,26E-03 0,02432583 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 2,26E-03 0,02421914 GO:0010810|regulation of cell-substrate adhesion, ! acetyl-CoA catabolic process GO:0046356 37 23 1,000 2,26E-03 0,02411338 GO:0006099|tricarboxylic acid cycle, ! negative regulation of growth GO:0045926 168 85 2,000 2,308E-03 0,02451672 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 2,461E-03 0,02602566 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 2,461E-03 0,02591348 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 2,461E-03 0,02580227 ! sex determination GO:0007530 48 24 1,000 2,461E-03 0,025692 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 2,461E-03 0,02558267 ! alcohol catabolic process GO:0046164 142 87 2,000 2,466E-03 0,02552787 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 2,67E-03 0,02751754 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 2,67E-03 0,02740192 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 2,67E-03 0,02728727 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 2,67E-03 0,02717357 ! regulation of behavior GO:0050795 48 25 1,000 2,67E-03 0,02706081 ! protein tetramerization GO:0051262 57 25 1,000 2,67E-03 0,02694899 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 2,886E-03 0,02901656 ! initiation of viral infection GO:0019059 60 26 1,000 2,886E-03 0,02889764 ! pyruvate metabolic process GO:0006090 43 26 1,000 2,886E-03 0,02877969 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 2,886E-03 0,0286627 GO:0045936|negative regulation of phosphate metabolic process, ! neural crest cell development GO:0014032 59 26 1,000 2,886E-03 0,02854665 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 1,000 2,886E-03 0,02843155 ! positive regulation of nuclear division GO:0051785 41 26 1,000 2,886E-03 0,02831736 GO:0045840|positive regulation of mitosis, ! neural tube closure GO:0001843 58 26 1,000 2,886E-03 0,02820409 GO:0060606|tube closure, ! regulation of cell morphogenesis GO:0022604 243 93 2,000 2,979E-03 0,02899741 ! nitrogen compound catabolic process GO:0044270 167 94 2,000 3,071E-03 0,02976856 ! tube lumen formation GO:0035148 59 27 1,000 3,111E-03 0,03003916 ! cellular response to oxidative stress GO:0034599 43 27 1,000 3,111E-03 0,02992089 ! regulation of chromosome organization GO:0033044 49 27 1,000 3,111E-03 0,02980356 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 3,344E-03 0,03190697 ! protein amino acid acylation GO:0043543 59 28 1,000 3,344E-03 0,03178282 ! leukocyte differentiation GO:0002521 232 98 2,000 3,454E-03 0,03270138 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 3,584E-03 0,03380592 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 3,584E-03 0,03367589 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 3,584E-03 0,03354687 ! somitogenesis GO:0001756 52 29 1,000 3,584E-03 0,03341883 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 3,584E-03 0,03329176 ! primary neural tube formation GO:0014020 61 29 1,000 3,584E-03 0,03316565 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 3,832E-03 0,03532993 ! regulation of B cell activation GO:0050864 55 30 1,000 3,832E-03 0,03519711 ! iron ion homeostasis GO:0055072 60 31 1,000 4,088E-03 0,03740884 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 4,088E-03 0,03726926 ! cofactor catabolic process GO:0051187 54 31 1,000 4,088E-03 0,03713071 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 4,352E-03 0,03938074 ! collagen metabolic process GO:0032963 49 32 1,000 4,352E-03 0,03923542 ! spindle organization GO:0007051 50 32 1,000 4,352E-03 0,03909117 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 4,624E-03 0,04137812 ! DNA damage checkpoint GO:0000077 78 35 1,000 5,19E-03 0,04627364 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 5,19E-03 0,04610537 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 5,19E-03 0,04593832 ! calcium-mediated signaling GO:0019722 67 35 1,000 5,19E-03 0,04577248 ! placenta development GO:0001890 53 35 1,000 5,19E-03 0,04560783 ! regulation of muscle development GO:0048634 82 36 1,000 5,484E-03 0,04802173 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 5,484E-03 0,04785022 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 5,484E-03 0,04767994 ! aerobic respiration GO:0009060 56 36 1,000 5,484E-03 0,04751086 ! embryonic organ development GO:0048568 67 36 1,000 5,484E-03 0,04734298 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 5,786E-03 0,04977276 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 5,786E-03 0,04959812 ! sister chromatid segregation GO:0000819 65 37 1,000 5,786E-03 0,0494247 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 6,095E-03 0,05188524 ! meiosis I GO:0007127 74 38 1,000 6,095E-03 0,05170509 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 6,095E-03 0,05152618 ! DNA integrity checkpoint GO:0031570 82 38 1,000 6,095E-03 0,0513485 ! neural tube formation GO:0001841 79 38 1,000 6,095E-03 0,05117204 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 6,412E-03 0,0536464 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 6,412E-03 0,05346331 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mismatch repair GO:0006298 58 40 1,000 6,736E-03 0,05597415 ! cellular amide metabolic process GO:0043603 73 41 1,000 7,068E-03 0,05852848 ! mesenchymal cell development GO:0014031 94 41 1,000 7,068E-03 0,05833075 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! embryonic epithelial tube formation GO:0001838 85 41 1,000 7,068E-03 0,05813435 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 7,406E-03 0,06071524 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 7,752E-03 0,06333781 GO:0090047|positive regulation of transcription regulator activity, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 1,000 7,752E-03 0,06312668 ! glucose transport GO:0015758 66 43 1,000 7,752E-03 0,06291696 ! segmentation GO:0035282 78 43 1,000 7,752E-03 0,06270862 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 7,752E-03 0,06250166 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 8,105E-03 0,06513281 ! hexose transport GO:0008645 68 44 1,000 8,105E-03 0,06491926 GO:0015749|monosaccharide transport, ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 8,465E-03 0,06758216 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 8,832E-03 0,07028401 ! negative regulation of cell migration GO:0030336 122 46 1,000 8,832E-03 0,07005581 ! neural tube development GO:0021915 91 47 1,000 9,206E-03 0,07278774 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 9,588E-03 0,07555706 ! positive regulation of DNA binding GO:0043388 83 48 1,000 9,588E-03 0,07531411 ! vascular process in circulatory system GO:0003018 85 48 1,000 9,588E-03 0,07507272 ! JAK-STAT cascade GO:0007259 82 48 1,000 9,588E-03 0,07483287 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 9,976E-03 0,07761438 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,01037085 0,08043167 ! viral infectious cycle GO:0019058 104 51 1,000 0,01077272 0,08328407 ! positive regulation of binding GO:0051099 88 52 1,000 0,0111814 0,08617089 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,0111814 0,08589991 ! histone modification GO:0016570 104 52 1,000 0,0111814 0,08563063 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,01159684 0,08853464 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,01159684 0,08825883 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01159684 0,08798473 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01201899 0,09090525 GO:0010863|positive regulation of phospholipase C activity, ! membrane fusion GO:0006944 122 54 1,000 0,01201899 0,09062468 ! covalent chromatin modification GO:0016569 115 54 1,000 0,01201899 0,09034583 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,01201899 0,0900687 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01244781 0,09299694 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,01244781 0,09271341 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,01244781 0,09243161 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,01244781 0,09215151 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,01244781 0,09187311 ! regulation of DNA replication GO:0006275 105 56 1,000 0,01288325 0,09480056 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,01332527 0,0977587 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01332527 0,09746601 ! regulation of actin filament length GO:0030832 118 58 1,000 0,01377383 0,1004462 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,01377383 0,10014725 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,01377383 0,09985008 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01377383 0,09955467 ! lipid modification GO:0030258 112 60 1,000 0,01469039 0,10586614 ! regulation of cellular component size GO:0032535 125 61 1,000 0,0151583 0,10891684 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01524021 0,10918424 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01524021 0,10886499 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01524021 0,1085476 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01524021 0,10823205 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01524021 0,10791833 ! neuron fate determination GO:0048664 7 5 0,000 0,01524021 0,10760643 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01524021 0,10729633 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01524021 0,106988 ! polyol transport GO:0015791 12 5 0,000 0,01524021 0,10668145 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01524021 0,10637664 ! response to superoxide GO:0000303 10 5 0,000 0,01524021 0,10607358 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01524021 0,10577223 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01524021 0,10547259 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01524021 0,10517465 ! female meiosis GO:0007143 10 5 0,000 0,01524021 0,10487838 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01524021 0,10458378 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01524021 0,10429083 ! hypothalamus development GO:0021854 9 5 0,000 0,01524021 0,10399951 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01524021 0,10370982 ! cobalt ion transport GO:0006824 11 5 0,000 0,01524021 0,10342174 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01524021 0,10313525 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01524021 0,10285035 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01524021 0,10256701 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01524021 0,10228523 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01524021 0,102005 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01524021 0,1017263 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01524021 0,10144912 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01524021 0,10117344 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01524021 0,10089926 ! transposition GO:0032196 9 5 0,000 0,01524021 0,10062655 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01524021 0,10035532 ! negative chemotaxis GO:0050919 16 5 0,000 0,01524021 0,10008555 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01524021 0,09981723 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01524021 0,09955033 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01524021 0,09928487 ! behavioral response to pain GO:0048266 10 5 0,000 0,01524021 0,09902081 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01524021 0,09875816 ! Notch receptor processing GO:0007220 11 5 0,000 0,01524021 0,09849689 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01524021 0,09823701 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01524021 0,09797849 ! micturition GO:0060073 9 5 0,000 0,01524021 0,09772133 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01524021 0,09746551 ! copulation GO:0007620 9 5 0,000 0,01524021 0,09721103 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01524021 0,09695788 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01524021 0,09670604 ! bioluminescence GO:0008218 9 5 0,000 0,01524021 0,09645551 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01524021 0,09620627 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01524021 0,09595831 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01524021 0,09571163 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01524021 0,09546622 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01524021 0,09522206 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01524021 0,09497915 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01524021 0,09473747 ! grooming behavior GO:0007625 6 5 0,000 0,01524021 0,09449702 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01524021 0,09425779 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01524021 0,09401976 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01524021 0,09378294 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01524021 0,0935473 ! response to protozoan GO:0001562 13 5 0,000 0,01524021 0,09331285 ! lymph vessel development GO:0001945 10 5 0,000 0,01524021 0,09307956 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01524021 0,09284744 ! endochondral ossification GO:0001958 17 5 0,000 0,01524021 0,09261648 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01524021 0,09238666 ! single strand break repair GO:0000012 8 5 0,000 0,01524021 0,09215798 ! parathyroid gland development GO:0060017 14 5 0,000 0,01524021 0,09193043 ! anagen GO:0042640 7 5 0,000 0,01524021 0,091704 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01524021 0,09147869 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01524021 0,09125447 ! cytokine secretion GO:0050663 15 5 0,000 0,01524021 0,09103136 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01524021 0,09080933 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01524021 0,09058838 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01524021 0,09036851 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01524021 0,0901497 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01524021 0,08993195 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01524021 0,08971524 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01524021 0,08949958 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01524021 0,08928495 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01524021 0,08907135 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01524021 0,08885877 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01524021 0,0886472 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01524021 0,08843664 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01524021 0,08822707 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01524021 0,0880185 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01524021 0,08781091 ! microvillus organization GO:0032528 8 5 0,000 0,01524021 0,08760429 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01524021 0,08739865 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01524021 0,08719397 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01524021 0,08699025 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01524021 0,08678747 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01524021 0,08658564 ! polyol catabolic process GO:0046174 9 5 0,000 0,01524021 0,08638475 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01524021 0,08618478 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01524021 0,08598574 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01524021 0,08578762 ! muscle cell migration GO:0014812 8 5 0,000 0,01524021 0,0855904 ! mitochondrial fission GO:0000266 8 5 0,000 0,01524021 0,08539409 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01524021 0,08519868 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01524021 0,08500417 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01524021 0,08481054 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01524021 0,08461778 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01524021 0,08442591 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01524021 0,0842349 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01524021 0,08404475 ! monocyte activation GO:0042117 10 5 0,000 0,01524021 0,08385546 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01524021 0,08366702 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01524021 0,08347943 ! response to food GO:0032094 6 5 0,000 0,01524021 0,08329267 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01524021 0,08310675 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01524021 0,08292166 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01524021 0,08273739 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01524021 0,08255394 ! forebrain neuron development GO:0021884 13 5 0,000 0,01524021 0,08237129 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01524021 0,08218946 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01524021 0,08200843 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01524021 0,08182819 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01524021 0,08164874 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01524021 0,08147008 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01524021 0,08129219 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01524021 0,08111509 ! lipid glycosylation GO:0030259 7 5 0,000 0,01524021 0,08093875 ! nucleobase transport GO:0015851 6 5 0,000 0,01524021 0,08076318 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01524021 0,08058837 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01524021 0,08041431 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01524021 0,080241 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01524021 0,08006844 ! basic amino acid transport GO:0015802 12 5 0,000 0,01524021 0,07989662 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01524021 0,07972554 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01524021 0,07955518 ! actin nucleation GO:0045010 11 5 0,000 0,01524021 0,07938555 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01524021 0,07921665 ! depurination GO:0045007 5 5 0,000 0,01524021 0,07904846 ! depyrimidination GO:0045008 10 5 0,000 0,01524021 0,07888099 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01524021 0,07871422 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01524021 0,07854815 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01524021 0,07838279 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01524021 0,07821812 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01524021 0,07805414 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01524021 0,07789085 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01524021 0,07772824 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01524021 0,0775663 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01524021 0,07740504 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01524021 0,07724445 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01524021 0,07708452 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01524021 0,07692526 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01524021 0,07676665 ! response to arsenic GO:0046685 11 5 0,000 0,01524021 0,07660869 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01524021 0,07645139 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01524021 0,07629472 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01524021 0,0761387 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01524021 0,07598332 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01524021 0,07582856 ! response to mercury ion GO:0046689 8 5 0,000 0,01524021 0,07567444 ! response to cadmium ion GO:0046686 7 5 0,000 0,01524021 0,07552094 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01524021 0,07536807 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01524021 0,07521581 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01524021 0,07506416 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01524021 0,07491313 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01524021 0,0747627 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01524021 0,07461288 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01524021 0,07446365 ! decidualization GO:0046697 11 5 0,000 0,01524021 0,07431502 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01524021 0,07416698 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01524021 0,07401953 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01524021 0,07387267 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01524021 0,07372639 ! embryonic cleavage GO:0040016 6 5 0,000 0,01524021 0,07358068 ! peroxisome fission GO:0016559 5 5 0,000 0,01524021 0,07343555 ! histone demethylation GO:0016577 13 5 0,000 0,01524021 0,07329099 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01524021 0,073147 ! mitotic recombination GO:0006312 9 5 0,000 0,01524021 0,07300358 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01524021 0,07286071 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01524021 0,07271841 ! metaphase plate congression GO:0051310 7 5 0,000 0,01524021 0,07257666 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01524021 0,07243546 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,01524021 0,07229481 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01524021 0,0721547 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01524021 0,07201514 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01524021 0,07187611 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01524021 0,07173762 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01524021 0,07159966 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01524021 0,07146224 ! B cell homeostasis GO:0001782 13 5 0,000 0,01524021 0,07132534 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01524021 0,07118896 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01524021 0,0710531 ! metaphase GO:0051323 11 5 0,000 0,01524021 0,07091776 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01524021 0,07078294 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01524021 0,07064862 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01524021 0,07051482 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01524021 0,07038152 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01524021 0,07024873 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01524021 0,07011643 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01524021 0,06998463 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01524021 0,06985333 ! response to redox state GO:0051775 6 5 0,000 0,01524021 0,06972252 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01524021 0,0695922 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01524021 0,06946236 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01524021 0,06933301 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01524021 0,06920414 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01524021 0,06907574 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01524021 0,06894782 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01524021 0,06882038 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01524021 0,0686934 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01524021 0,0685669 ! striatum development GO:0021756 14 5 0,000 0,01524021 0,06844086 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01524021 0,06831528 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01524021 0,06819016 ! glial cell migration GO:0008347 10 5 0,000 0,01524021 0,06806549 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01524021 0,06794129 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01524021 0,06781753 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01524021 0,06769423 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01524021 0,06757137 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01524021 0,06744896 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01524021 0,06732699 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01524021 0,06720546 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01524021 0,06708437 ! neuroprotection GO:0043526 8 5 0,000 0,01524021 0,06696371 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01524021 0,06684349 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01524021 0,0667237 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01524021 0,06660434 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01524021 0,0664854 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01524021 0,06636689 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01524021 0,0662488 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01524021 0,06613113 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01524021 0,06601387 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01524021 0,06589704 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01524021 0,06578061 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01524021 0,06566459 ! spindle assembly GO:0051225 6 5 0,000 0,01524021 0,06554899 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01524021 0,06543379 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01524021 0,06531899 ! protein palmitoylation GO:0018345 12 5 0,000 0,01524021 0,0652046 ! drug metabolic process GO:0017144 7 5 0,000 0,01524021 0,0650906 ! stem cell division GO:0017145 11 5 0,000 0,01524021 0,06497701 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01524021 0,06486381 ! organ regeneration GO:0031100 7 5 0,000 0,01524021 0,064751 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01524021 0,06463859 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01524021 0,06452656 ! regulation of mitosis GO:0007088 112 63 1,000 0,01611317 0,06810461 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 1,000 0,01611317 0,06798699 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,01611317 0,06786977 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,01660004 0,06980017 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01809791 0,0759677 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,01809791 0,07583739 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,01809791 0,07570753 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01826052 0,07625717 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01826052 0,07612704 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01826052 0,07599735 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01826052 0,0758681 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01826052 0,07573929 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01826052 0,07561092 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01826052 0,07548298 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01826052 0,07535548 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01826052 0,0752284 ! response to oxygen radical GO:0000305 11 6 0,000 0,01826052 0,07510176 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01826052 0,07497554 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01826052 0,07484974 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01826052 0,07472436 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01826052 0,0745994 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01826052 0,07447486 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01826052 0,07435074 ! forebrain regionalization GO:0021871 9 6 0,000 0,01826052 0,07422703 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01826052 0,07410373 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01826052 0,07398084 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01826052 0,07385835 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01826052 0,07373627 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01826052 0,07361459 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01826052 0,07349332 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01826052 0,07337244 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01826052 0,07325196 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01826052 0,07313188 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01826052 0,07301218 ! malate metabolic process GO:0006108 13 6 0,000 0,01826052 0,07289288 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01826052 0,07277397 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01826052 0,07265545 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01826052 0,07253731 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01826052 0,07241955 ! protein refolding GO:0042026 15 6 0,000 0,01826052 0,07230218 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01826052 0,07218518 ! opsonization GO:0008228 8 6 0,000 0,01826052 0,07206857 ! mating behavior GO:0007617 7 6 0,000 0,01826052 0,07195233 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01826052 0,07183646 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01826052 0,07172097 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01826052 0,07160585 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01826052 0,0714911 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01826052 0,07137671 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01826052 0,07126269 ! toxin metabolic process GO:0009404 11 6 0,000 0,01826052 0,07114903 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01826052 0,07103574 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01826052 0,0709228 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01826052 0,07081023 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01826052 0,07069801 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01826052 0,07058615 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01826052 0,07047464 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01826052 0,07036348 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01826052 0,07025267 ! thymic T cell selection GO:0045061 16 6 0,000 0,01826052 0,07014221 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01826052 0,07003209 ! protein lipoylation GO:0009249 10 6 0,000 0,01826052 0,06992233 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01826052 0,0698129 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01826052 0,06970382 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01826052 0,06959508 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01826052 0,06948667 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01826052 0,06937861 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01826052 0,06927088 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01826052 0,06916348 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01826052 0,06905641 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01826052 0,06894968 ! hyperosmotic response GO:0006972 10 6 0,000 0,01826052 0,06884328 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01826052 0,0687372 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01826052 0,06863145 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01826052 0,06852603 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01826052 0,06842093 ! urea metabolic process GO:0019627 7 6 0,000 0,01826052 0,06831615 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01826052 0,06821169 ! neutrophil activation GO:0042119 7 6 0,000 0,01826052 0,06810755 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01826052 0,06800373 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01826052 0,06790022 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01826052 0,06779703 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01826052 0,06769415 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01826052 0,06759158 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01826052 0,06748933 ! neuron apoptosis GO:0051402 15 6 0,000 0,01826052 0,06738738 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01826052 0,06728574 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01826052 0,0671844 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01826052 0,06708337 ! carnitine transport GO:0015879 10 6 0,000 0,01826052 0,06698265 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01826052 0,06688222 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01826052 0,0667821 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01826052 0,06668228 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01826052 0,06658275 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01826052 0,06648352 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01826052 0,06638459 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01826052 0,06628595 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01826052 0,0661876 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01826052 0,06608955 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01826052 0,06599178 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01826052 0,0658943 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01826052 0,06579712 ! response to UV-C GO:0010225 14 6 0,000 0,01826052 0,06570021 ! astrocyte development GO:0014002 16 6 0,000 0,01826052 0,06560359 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01826052 0,06550726 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01826052 0,06541121 ! interaction with symbiont GO:0051702 14 6 0,000 0,01826052 0,06531544 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01826052 0,06521995 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01826052 0,06512474 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01826052 0,0650298 ! response to copper ion GO:0046688 10 6 0,000 0,01826052 0,06493514 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01826052 0,06484076 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01826052 0,06474665 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01826052 0,06465282 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01826052 0,06455925 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01826052 0,06446596 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01826052 0,06437294 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01826052 0,06428018 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01826052 0,06418769 ! hair follicle maturation GO:0048820 8 6 0,000 0,01826052 0,06409547 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01826052 0,06400351 ! Schwann cell development GO:0014044 15 6 0,000 0,01826052 0,06391181 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01826052 0,06382038 ! response to pheromone GO:0019236 6 6 0,000 0,01826052 0,06372921 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01826052 0,06363829 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01826052 0,06354764 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01826052 0,06345725 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01826052 0,06336711 ! subpallium development GO:0021544 15 6 0,000 0,01826052 0,06327723 ! neural tube patterning GO:0021532 8 6 0,000 0,01826052 0,0631876 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01826052 0,06309822 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01826052 0,0630091 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01826052 0,06292023 ! G2 phase GO:0051319 16 6 0,000 0,01826052 0,06283161 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01826052 0,06274324 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01826052 0,06265512 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01826052 0,06256724 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01826052 0,06247961 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01826052 0,06239223 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01826052 0,06230509 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01826052 0,06221819 ! receptor internalization GO:0031623 11 6 0,000 0,01826052 0,06213154 ! plasminogen activation GO:0031639 9 6 0,000 0,01826052 0,06204512 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01826052 0,06195895 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01826052 0,06187302 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01826052 0,06178732 ! protein deubiquitination GO:0016579 16 6 0,000 0,01826052 0,06170186 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01826052 0,06161664 ! protein destabilization GO:0031648 9 6 0,000 0,01826052 0,06153165 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01826052 0,06144689 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01826052 0,06136237 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01826052 0,06127808 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01826052 0,06119402 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01826052 0,0611102 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01826052 0,0610266 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01826052 0,06094323 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01826052 0,06086009 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01826052 0,06077717 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01826052 0,06069448 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01826052 0,06061202 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01826052 0,06052977 ! neural plate development GO:0001840 9 6 0,000 0,01826052 0,06044776 ! catecholamine transport GO:0051937 9 6 0,000 0,01826052 0,06036596 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01826052 0,06028438 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01826052 0,06020303 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01826052 0,06012189 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01826052 0,06004097 ! maternal placenta development GO:0001893 12 6 0,000 0,01826052 0,05996027 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01826052 0,05987979 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01826052 0,05979952 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01826052 0,05971947 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01826052 0,05963963 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01826052 0,05956001 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01826052 0,05948059 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01826052 0,05940139 GO:0055081|anion homeostasis, ! regulation of lipase activity GO:0060191 137 68 1,000 0,01860948 0,06045606 ! adaptive immune response GO:0002250 126 68 1,000 0,01860948 0,06037578 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of cell size GO:0045792 144 69 1,000 0,01912712 0,06197288 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,02018044 0,06529908 ! appendage morphogenesis GO:0035107 150 72 1,000 0,02071603 0,06694348 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 1,000 0,02071603 0,06685505 ! actin filament organization GO:0007015 167 72 1,000 0,02071603 0,06676685 ! coenzyme biosynthetic process GO:0009108 119 72 1,000 0,02071603 0,06667888 ! appendage development GO:0048736 151 73 1,000 0,02125754 0,06833179 GO:0060173|limb development, ! tRNA transcription GO:0009304 17 7 0,000 0,02127165 0,06828731 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02127165 0,06819769 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02127165 0,06810831 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02127165 0,06801916 ! regulation of helicase activity GO:0051095 16 7 0,000 0,02127165 0,06793025 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02127165 0,06784157 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02127165 0,06775311 ! sleep GO:0030431 16 7 0,000 0,02127165 0,06766489 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02127165 0,0675769 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02127165 0,06748914 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02127165 0,06740161 ! prostate gland development GO:0030850 14 7 0,000 0,02127165 0,0673143 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02127165 0,06722722 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02127165 0,06714036 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02127165 0,06705373 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02127165 0,06696732 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02127165 0,06688113 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02127165 0,06679517 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02127165 0,06670942 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02127165 0,0666239 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02127165 0,06653859 ! glycolipid transport GO:0046836 11 7 0,000 0,02127165 0,0664535 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02127165 0,06636863 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02127165 0,06628398 ! neuron adhesion GO:0007158 14 7 0,000 0,02127165 0,06619954 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02127165 0,06611532 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02127165 0,06603131 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02127165 0,06594751 ! pericardium development GO:0060039 16 7 0,000 0,02127165 0,06586393 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02127165 0,06578056 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02127165 0,06569739 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02127165 0,06561444 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02127165 0,0655317 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02127165 0,06544917 ! lipoprotein transport GO:0042953 14 7 0,000 0,02127165 0,06536684 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02127165 0,06528472 ! rhythmic behavior GO:0007622 17 7 0,000 0,02127165 0,06520281 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02127165 0,0651211 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02127165 0,0650396 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02127165 0,0649583 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02127165 0,0648772 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02127165 0,06479631 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02127165 0,06471562 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02127165 0,06463512 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02127165 0,06455483 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02127165 0,06447474 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02127165 0,06439484 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02127165 0,06431515 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02127165 0,06423565 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02127165 0,06415634 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02127165 0,06407724 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02127165 0,06399832 ! spinal cord patterning GO:0021511 14 7 0,000 0,02127165 0,06391961 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02127165 0,06384108 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02127165 0,06376275 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02127165 0,06368461 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02127165 0,06360666 ! adrenal gland development GO:0030325 17 7 0,000 0,02127165 0,0635289 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02127165 0,06345133 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02127165 0,06337395 ! ovulation GO:0030728 10 7 0,000 0,02127165 0,06329676 ! adenohypophysis development GO:0021984 11 7 0,000 0,02127165 0,06321976 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02127165 0,06314294 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02127165 0,06306631 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02127165 0,06298987 ! microtubule nucleation GO:0007020 21 7 0,000 0,02127165 0,06291361 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02127165 0,06283753 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02127165 0,06276164 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02127165 0,06268593 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02127165 0,06261041 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02127165 0,06253507 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02127165 0,0624599 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02127165 0,06238492 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02127165 0,06231012 ! galactose metabolic process GO:0006012 13 7 0,000 0,02127165 0,0622355 ! vesicle fusion GO:0006906 20 7 0,000 0,02127165 0,06216105 ! response to dietary excess GO:0002021 8 7 0,000 0,02127165 0,06208679 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02127165 0,0620127 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02127165 0,06193878 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02127165 0,06186505 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02127165 0,06179149 ! organ growth GO:0035265 15 7 0,000 0,02127165 0,0617181 ! nucleoside transport GO:0015858 11 7 0,000 0,02127165 0,06164489 ! nucleoside salvage GO:0043174 11 7 0,000 0,02127165 0,06157185 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02127165 0,06149898 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02127165 0,06142629 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02127165 0,06135377 ! parturition GO:0007567 16 7 0,000 0,02127165 0,06128141 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02127165 0,06120923 ! rRNA modification GO:0000154 14 7 0,000 0,02127165 0,06113722 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02127165 0,06106538 ! spindle checkpoint GO:0031577 16 7 0,000 0,02127165 0,06099371 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02127165 0,0609222 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02127165 0,06085087 ! monocyte differentiation GO:0030224 16 7 0,000 0,02127165 0,06077969 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02127165 0,06070869 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02127165 0,06063785 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02127165 0,06056718 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02127165 0,06049667 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,02127165 0,06042632 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02127165 0,06035614 ! fibrinolysis GO:0042730 11 7 0,000 0,02127165 0,06028612 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02127165 0,06021627 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02127165 0,06014657 ! eating behavior GO:0042755 8 7 0,000 0,02127165 0,06007704 ! B cell lineage commitment GO:0002326 21 7 0,000 0,02127165 0,06000767 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02127165 0,05993845 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02127165 0,0598694 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02127165 0,05980051 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02127165 0,05973177 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02127165 0,05966319 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02127165 0,05959477 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02127165 0,05952651 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02127165 0,0594584 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02127165 0,05939044 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02127165 0,05932265 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02127165 0,059255 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02127165 0,05918752 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02127165 0,05912018 ! histone ubiquitination GO:0016574 9 7 0,000 0,02127165 0,059053 ! regulation of meiosis GO:0040020 12 7 0,000 0,02127165 0,05898597 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02127165 0,05891909 ! T cell lineage commitment GO:0002360 16 7 0,000 0,02127165 0,05885237 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02127165 0,05878579 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02127165 0,05871937 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02127165 0,05865309 ! transcription termination GO:0006353 14 7 0,000 0,02127165 0,05858697 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02127165 0,05852099 ! anaphase GO:0051322 18 7 0,000 0,02127165 0,05845516 GO:0000090|mitotic anaphase, ! axonal fasciculation GO:0007413 19 7 0,000 0,02127165 0,05838948 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02127165 0,05832395 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02127165 0,05825856 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02127165 0,05819332 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02127165 0,05812823 ! diuresis GO:0030146 12 7 0,000 0,02127165 0,05806328 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02127165 0,05799848 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02127165 0,05793382 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02127165 0,05786931 ! antibiotic transport GO:0042891 9 7 0,000 0,02127165 0,05780494 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02127165 0,05774071 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02127165 0,05767662 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02127165 0,05761268 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02127165 0,05754888 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02127165 0,05748522 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02127165 0,0574217 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02127165 0,05735832 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02127165 0,05729508 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02127165 0,05723198 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02127165 0,05716902 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02127165 0,0571062 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02127165 0,05704351 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02127165 0,05698096 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02127165 0,05691855 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02127165 0,05685628 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02127165 0,05679414 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02127165 0,05673214 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02127165 0,05667027 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02127165 0,05660854 ! muscle adaptation GO:0043500 13 7 0,000 0,02127165 0,05654694 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02127165 0,05648548 ! retina homeostasis GO:0001895 12 7 0,000 0,02127165 0,05642415 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02127165 0,05636295 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02127165 0,05630188 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02127165 0,05624095 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02127165 0,05618015 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,02180491 0,05752633 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,0223581 0,05892215 GO:0090046|regulation of transcription regulator activity, ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,02291708 0,06033019 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,0234818 0,0617503 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,02405222 0,06318234 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02427363 0,06369547 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02427363 0,06362712 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02427363 0,06355893 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02427363 0,06349088 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02427363 0,06342297 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02427363 0,06335521 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02427363 0,0632876 ! male meiosis GO:0007140 9 8 0,000 0,02427363 0,06322013 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02427363 0,0631528 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02427363 0,06308562 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02427363 0,06301857 ! meiotic prophase I GO:0007128 14 8 0,000 0,02427363 0,06295168 ! response to zinc ion GO:0010043 12 8 0,000 0,02427363 0,06288492 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02427363 0,0628183 ! oligopeptide transport GO:0006857 16 8 0,000 0,02427363 0,06275183 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02427363 0,06268549 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02427363 0,0626193 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02427363 0,06255325 ! signal peptide processing GO:0006465 12 8 0,000 0,02427363 0,06248733 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02427363 0,06242156 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02427363 0,06235592 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02427363 0,06229042 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02427363 0,06222506 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02427363 0,06215983 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02427363 0,06209474 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02427363 0,06202979 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02427363 0,06196497 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02427363 0,06190029 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02427363 0,06183574 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02427363 0,06177133 ! reflex GO:0060004 17 8 0,000 0,02427363 0,06170705 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02427363 0,06164291 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02427363 0,0615789 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02427363 0,06151502 ! pigment granule organization GO:0048753 17 8 0,000 0,02427363 0,06145127 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02427363 0,06138766 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02427363 0,06132418 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02427363 0,06126082 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02427363 0,0611976 ! histidine catabolic process GO:0006548 10 8 0,000 0,02427363 0,06113451 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02427363 0,06107155 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02427363 0,06100872 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02427363 0,06094602 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02427363 0,06088345 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02427363 0,060821 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02427363 0,06075869 ! melanin metabolic process GO:0006582 17 8 0,000 0,02427363 0,0606965 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02427363 0,06063444 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02427363 0,0605725 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02427363 0,06051069 ! macrophage activation GO:0042116 13 8 0,000 0,02427363 0,06044901 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02427363 0,06038745 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02427363 0,06032602 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02427363 0,06026471 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02427363 0,06020353 ! purine salvage GO:0043101 12 8 0,000 0,02427363 0,06014247 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02427363 0,06008154 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02427363 0,06002073 ! osteoblast development GO:0002076 17 8 0,000 0,02427363 0,05996004 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02427363 0,05989947 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02427363 0,05983903 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02427363 0,05977871 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02427363 0,05971851 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02427363 0,05965843 ! response to UV-B GO:0010224 17 8 0,000 0,02427363 0,05959847 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02427363 0,05953863 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02427363 0,05947891 ! intermediate filament organization GO:0045109 12 8 0,000 0,02427363 0,05941932 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02427363 0,05935984 ! cellular extravasation GO:0045123 13 8 0,000 0,02427363 0,05930048 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02427363 0,05924124 ! response to antibiotic GO:0046677 11 8 0,000 0,02427363 0,05918211 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02427363 0,05912311 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02427363 0,05906422 ! DNA topological change GO:0006265 12 8 0,000 0,02427363 0,05900545 ! response to tropane GO:0014073 15 8 0,000 0,02427363 0,0589468 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02427363 0,05888826 ! melanosome transport GO:0032402 13 8 0,000 0,02427363 0,05882984 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02427363 0,05877153 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02427363 0,05871334 ! mast cell activation GO:0045576 14 8 0,000 0,02427363 0,05865527 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02427363 0,05859731 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02427363 0,05853947 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02427363 0,05848173 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02427363 0,05842412 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02427363 0,05836661 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02427363 0,05830922 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02427363 0,05825194 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02427363 0,05819478 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02427363 0,05813772 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02427363 0,05808078 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02427363 0,05802395 ! response to tumor cell GO:0002347 16 8 0,000 0,02427363 0,05796723 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02427363 0,05791062 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02427363 0,05785412 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02427363 0,05779774 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02427363 0,05774146 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02427363 0,05768529 ! hormone catabolic process GO:0042447 17 8 0,000 0,02427363 0,05762923 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02427363 0,05757328 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02427363 0,05751744 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02427363 0,0574617 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02427363 0,05740608 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02427363 0,05735056 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02427363 0,05729515 ! adult feeding behavior GO:0008343 10 8 0,000 0,02427363 0,05723984 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02427363 0,05718465 ! ATP catabolic process GO:0006200 11 8 0,000 0,02427363 0,05712956 ! blastocyst growth GO:0001832 19 8 0,000 0,02427363 0,05707457 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02427363 0,05701969 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02427363 0,05696492 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02427363 0,05691025 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02427363 0,05685568 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02427363 0,05680122 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02427363 0,05674687 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02427363 0,05669262 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02427363 0,05663847 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02427363 0,05658443 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02427363 0,05653048 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02427363 0,05647665 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02427363 0,05642291 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02427363 0,05636928 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02427363 0,05631574 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02427363 0,05626231 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02427363 0,05620898 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02427363 0,05615576 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02427363 0,05610263 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02427363 0,0560496 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,02462831 0,05681489 ! protein oligomerization GO:0051259 149 79 1,000 0,02462831 0,05676129 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,02521003 0,05804722 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,02521003 0,05799256 ! meiosis GO:0007126 143 81 1,000 0,02579733 0,05928775 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 144 82 1,000 0,02639018 0,06059324 ! axon extension GO:0048675 16 9 0,000 0,02726649 0,06254651 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02726649 0,06248783 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02726649 0,06242927 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02726649 0,06237081 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02726649 0,06231247 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02726649 0,06225423 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02726649 0,0621961 ! reproductive behavior GO:0019098 22 9 0,000 0,02726649 0,06213809 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02726649 0,06208018 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02726649 0,06202237 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02726649 0,06196468 ! UTP metabolic process GO:0046051 10 9 0,000 0,02726649 0,06190709 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02726649 0,06184961 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02726649 0,06179223 ! artery development GO:0060840 25 9 0,000 0,02726649 0,06173497 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02726649 0,0616778 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02726649 0,06162075 ! equilibrioception GO:0050957 20 9 0,000 0,02726649 0,0615638 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02726649 0,06150695 ! chemosensory behavior GO:0007635 21 9 0,000 0,02726649 0,06145021 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02726649 0,06139357 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02726649 0,06133704 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02726649 0,06128061 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02726649 0,06122429 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02726649 0,06116807 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02726649 0,06111195 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02726649 0,06105594 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02726649 0,06100003 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02726649 0,06094422 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02726649 0,06088851 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02726649 0,0608329 ! protein targeting to ER GO:0045047 25 9 0,000 0,02726649 0,0607774 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02726649 0,06072199 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02726649 0,06066669 ! T cell selection GO:0045058 27 9 0,000 0,02726649 0,06061149 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02726649 0,06055639 ! glycine catabolic process GO:0006546 15 9 0,000 0,02726649 0,06050139 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02726649 0,06044649 ! endosome organization GO:0007032 20 9 0,000 0,02726649 0,06039168 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02726649 0,06033698 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02726649 0,06028238 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02726649 0,06022787 ! mannose metabolic process GO:0006013 13 9 0,000 0,02726649 0,06017347 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02726649 0,06011916 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02726649 0,06006495 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02726649 0,06001084 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02726649 0,05995682 ! receptor clustering GO:0043113 20 9 0,000 0,02726649 0,0599029 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02726649 0,05984908 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02726649 0,05979536 ! retinol metabolic process GO:0042572 20 9 0,000 0,02726649 0,05974173 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02726649 0,0596882 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02726649 0,05963476 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02726649 0,05958142 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02726649 0,05952818 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02726649 0,05947503 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02726649 0,05942197 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02726649 0,05936901 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02726649 0,05931614 ! response to amine stimulus GO:0014075 13 9 0,000 0,02726649 0,05926337 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02726649 0,05921069 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02726649 0,05915811 ! erythrocyte development GO:0048821 17 9 0,000 0,02726649 0,05910562 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02726649 0,05905322 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02726649 0,05900091 ! renal water homeostasis GO:0003091 15 9 0,000 0,02726649 0,0589487 ! postreplication repair GO:0006301 25 9 0,000 0,02726649 0,05889658 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02726649 0,05884455 ! icosanoid secretion GO:0032309 15 9 0,000 0,02726649 0,05879261 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02726649 0,05874077 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02726649 0,05868901 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02726649 0,05863735 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02726649 0,05858578 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02726649 0,0585343 ! sterol catabolic process GO:0016127 14 9 0,000 0,02726649 0,0584829 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02726649 0,0584316 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02726649 0,05838039 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02726649 0,05832927 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02726649 0,05827824 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02726649 0,0582273 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02726649 0,05817644 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02726649 0,05812568 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02726649 0,058075 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02726649 0,05802441 ! purine base metabolic process GO:0006144 25 9 0,000 0,02726649 0,05797391 ! pigment granule transport GO:0051904 17 9 0,000 0,02726649 0,0579235 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02726649 0,05787318 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02726649 0,05782294 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02726649 0,05777279 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02726649 0,05772273 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02726649 0,05767275 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02726649 0,05762286 ! mitochondrion localization GO:0051646 18 9 0,000 0,02726649 0,05757306 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,02881627 0,06079288 GO:0002696|positive regulation of leukocyte activation, ! cellular respiration GO:0045333 143 88 1,000 0,0300616 0,06336539 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,03025025 0,06370807 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,03025025 0,06365319 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03025025 0,06359841 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,03025025 0,06354373 ! associative learning GO:0008306 21 10 0,000 0,03025025 0,06348914 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03025025 0,06343464 ! phosphate transport GO:0006817 24 10 0,000 0,03025025 0,06338024 ! cell volume homeostasis GO:0006884 17 10 0,000 0,03025025 0,06332593 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,03025025 0,06327171 ! CTP metabolic process GO:0046036 11 10 0,000 0,03025025 0,06321758 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,03025025 0,06316355 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,03025025 0,06310961 ! GTP metabolic process GO:0046039 11 10 0,000 0,03025025 0,06305577 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,03025025 0,06300201 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,03025025 0,06294834 ! social behavior GO:0035176 29 10 0,000 0,03025025 0,06289477 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,03025025 0,06284129 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,03025025 0,0627879 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,03025025 0,0627346 ! androgen metabolic process GO:0008209 17 10 0,000 0,03025025 0,06268139 ! phospholipid efflux GO:0033700 19 10 0,000 0,03025025 0,06262827 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03025025 0,06257524 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,03025025 0,0625223 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,03025025 0,06246945 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,03025025 0,06241669 ! pathogenesis GO:0009405 17 10 0,000 0,03025025 0,06236401 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03025025 0,06231143 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,03025025 0,06225894 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,03025025 0,06220653 ! endoderm development GO:0007492 18 10 0,000 0,03025025 0,06215421 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,03025025 0,06210198 ! arginine catabolic process GO:0006527 17 10 0,000 0,03025025 0,06204984 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03025025 0,06199778 ! proline metabolic process GO:0006560 13 10 0,000 0,03025025 0,06194581 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03025025 0,06189393 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,03025025 0,06184214 ! V(D)J recombination GO:0033151 34 10 0,000 0,03025025 0,06179043 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,03025025 0,06173881 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,03025025 0,06168728 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,03025025 0,06163583 ! B cell proliferation GO:0042100 19 10 0,000 0,03025025 0,06158446 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,03025025 0,06153319 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,03025025 0,06148199 ! multicellular organism growth GO:0035264 19 10 0,000 0,03025025 0,06143089 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,03025025 0,06137986 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,03025025 0,06132893 ! ruffle organization GO:0031529 17 10 0,000 0,03025025 0,06127807 ! epithelial cell development GO:0002064 21 10 0,000 0,03025025 0,0612273 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,03025025 0,06117662 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03025025 0,06112602 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,03025025 0,0610755 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,03025025 0,06102507 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,03025025 0,06097472 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,03025025 0,06092445 ! motor axon guidance GO:0008045 22 10 0,000 0,03025025 0,06087426 ! copper ion homeostasis GO:0055070 13 10 0,000 0,03025025 0,06082416 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,03025025 0,06077414 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,03025025 0,0607242 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,03025025 0,06067435 ! segment specification GO:0007379 15 10 0,000 0,03025025 0,06062457 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,03025025 0,06057488 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,03025025 0,06052527 ! blastoderm segmentation GO:0007350 19 10 0,000 0,03025025 0,06047574 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,03025025 0,06042629 ! response to dsRNA GO:0043331 23 10 0,000 0,03025025 0,06037693 ! DNA ligation GO:0006266 18 10 0,000 0,03025025 0,06032764 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,03025025 0,06027843 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03025025 0,0602293 ! melanosome localization GO:0032400 16 10 0,000 0,03025025 0,06018026 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,03025025 0,06013129 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,03025025 0,0600824 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,03025025 0,0600336 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03025025 0,05998487 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,03025025 0,05993622 ! induction of an organ GO:0001759 17 10 0,000 0,03025025 0,05988765 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,03025025 0,05983916 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,03025025 0,05979074 ! protein sumoylation GO:0016925 17 10 0,000 0,03025025 0,05974241 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,03025025 0,05969415 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03025025 0,05964597 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03025025 0,05959787 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03025025 0,05954984 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,03025025 0,0595019 ! salivary gland development GO:0007431 28 10 0,000 0,03025025 0,05945403 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,03025025 0,05940624 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,03025025 0,05935852 ! midbrain development GO:0030901 14 10 0,000 0,03025025 0,05931088 ! musculoskeletal movement GO:0050881 16 10 0,000 0,03025025 0,05926332 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,03025025 0,05921583 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,03025025 0,05916842 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,03025025 0,05912109 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,03025025 0,05907383 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,03025025 0,05902664 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03025025 0,05897953 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03025025 0,0589325 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,03025025 0,05888554 ! detection of calcium ion GO:0005513 24 10 0,000 0,03025025 0,05883866 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03025025 0,05879185 ! blastocyst formation GO:0001825 18 10 0,000 0,03025025 0,05874512 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,03025025 0,05869846 ! cerebellar cortex development GO:0021695 16 10 0,000 0,03025025 0,05865187 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,03025025 0,05860536 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,03025025 0,05855892 ! response to nicotine GO:0035094 20 10 0,000 0,03025025 0,05851255 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,03025025 0,05846626 ! regulation of DNA binding GO:0051101 167 89 1,000 0,0306922 0,05927355 ! tube morphogenesis GO:0035239 194 89 1,000 0,0306922 0,05922673 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,03132804 0,060406 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,03132804 0,06035836 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,0326153 0,06278895 ! respiratory burst GO:0045730 17 11 0,000 0,03322494 0,06391223 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03322494 0,06386194 ! neuron fate specification GO:0048665 18 11 0,000 0,03322494 0,06381174 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03322494 0,06376161 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03322494 0,06371156 ! thyroid gland development GO:0030878 26 11 0,000 0,03322494 0,06366159 ! synapsis GO:0007129 14 11 0,000 0,03322494 0,0636117 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03322494 0,06356189 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03322494 0,06351215 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03322494 0,06346249 ! response to pain GO:0048265 27 11 0,000 0,03322494 0,06341291 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03322494 0,06336341 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03322494 0,06331399 ! bone resorption GO:0045453 16 11 0,000 0,03322494 0,06326464 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03322494 0,06321537 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03322494 0,06316617 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03322494 0,06311705 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03322494 0,06306801 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03322494 0,06301905 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03322494 0,06297016 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03322494 0,06292134 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03322494 0,0628726 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,03322494 0,06282394 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03322494 0,06277535 ! UV protection GO:0009650 20 11 0,000 0,03322494 0,06272684 ! adult heart development GO:0007512 16 11 0,000 0,03322494 0,0626784 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03322494 0,06263004 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03322494 0,06258175 ! macroautophagy GO:0016236 19 11 0,000 0,03322494 0,06253354 ! temperature homeostasis GO:0001659 18 11 0,000 0,03322494 0,0624854 ! behavioral fear response GO:0001662 27 11 0,000 0,03322494 0,06243733 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03322494 0,06238934 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03322494 0,06234142 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03322494 0,06229358 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03322494 0,06224581 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03322494 0,06219811 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03322494 0,06215048 ! regulation of organ growth GO:0046620 14 11 0,000 0,03322494 0,06210293 ! pigment granule localization GO:0051875 20 11 0,000 0,03322494 0,06205545 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03322494 0,06200804 ! vasoconstriction GO:0042310 20 11 0,000 0,03322494 0,06196071 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03322494 0,06191345 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03322494 0,06186626 ! embryonic axis specification GO:0000578 19 11 0,000 0,03322494 0,06181914 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03322494 0,06177209 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03322494 0,06172512 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03322494 0,06167821 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03322494 0,06163138 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03322494 0,06158462 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03322494 0,06153793 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03322494 0,06149131 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03322494 0,06144476 ! prophase GO:0051324 17 11 0,000 0,03322494 0,06139828 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03322494 0,06135187 ! nucleosome positioning GO:0016584 15 11 0,000 0,03322494 0,06130554 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03322494 0,06125927 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03322494 0,06121307 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03322494 0,06116694 ! apical protein localization GO:0045176 18 11 0,000 0,03322494 0,06112088 ! acid secretion GO:0046717 20 11 0,000 0,03322494 0,06107489 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03322494 0,06102897 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03322494 0,06098312 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03322494 0,06093734 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03322494 0,06089162 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03322494 0,06084597 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03322494 0,0608004 ! cholesterol efflux GO:0033344 21 11 0,000 0,03322494 0,06075489 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03322494 0,06070945 ! oocyte development GO:0048599 20 11 0,000 0,03322494 0,06066407 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03322494 0,06061877 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03322494 0,06057353 ! embryonic gut development GO:0048566 19 11 0,000 0,03322494 0,06052836 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03322494 0,06048326 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03322494 0,06043822 ! activation of innate immune response GO:0002218 16 11 0,000 0,03322494 0,06039325 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03322494 0,06034835 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03322494 0,06030351 ! lysogeny GO:0030069 22 11 0,000 0,03322494 0,06025875 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03322494 0,06021404 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03322494 0,06016941 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03322494 0,06012484 ! cofactor biosynthetic process GO:0051188 161 95 1,000 0,03458456 0,06253892 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,03458456 0,06249267 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 0,03592256 0,0648624 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03619059 0,06529809 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03619059 0,0652499 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,03619059 0,06520178 ! mating GO:0007618 17 12 0,000 0,03619059 0,06515373 ! protein complex disassembly GO:0043241 28 12 0,000 0,03619059 0,06510576 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03619059 0,06505785 ! hippocampus development GO:0021766 29 12 0,000 0,03619059 0,06501001 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,03619059 0,06496225 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03619059 0,06491455 ! T cell proliferation GO:0042098 32 12 0,000 0,03619059 0,06486692 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03619059 0,06481937 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03619059 0,06477188 ! ventral spinal cord development GO:0021517 25 12 0,000 0,03619059 0,06472446 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03619059 0,06467712 ! drug transport GO:0015893 16 12 0,000 0,03619059 0,06462984 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03619059 0,06458263 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03619059 0,06453549 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03619059 0,06448841 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03619059 0,06444141 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03619059 0,06439448 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03619059 0,06434761 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03619059 0,06430081 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,03619059 0,06425408 ! lipid digestion GO:0044241 21 12 0,000 0,03619059 0,06420742 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03619059 0,06416082 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03619059 0,0641143 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03619059 0,06406784 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03619059 0,06402145 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03619059 0,06397512 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03619059 0,06392886 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03619059 0,06388267 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,03619059 0,06383655 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03619059 0,06379049 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03619059 0,0637445 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03619059 0,06369857 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03619059 0,06365271 ! cranial nerve development GO:0021545 23 12 0,000 0,03619059 0,06360692 ! fucose catabolic process GO:0019317 25 12 0,000 0,03619059 0,06356119 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03619059 0,06351553 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03619059 0,06346993 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03619059 0,0634244 ! zymogen activation GO:0031638 18 12 0,000 0,03619059 0,06337894 ! T cell homeostasis GO:0043029 28 12 0,000 0,03619059 0,06333354 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03619059 0,0632882 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03619059 0,06324293 ! oocyte differentiation GO:0009994 21 12 0,000 0,03619059 0,06319772 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03619059 0,06315258 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03619059 0,06310751 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,03619059 0,06306249 GO:0042130|negative regulation of T cell proliferation, ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03619059 0,06301755 ! defense response to fungus GO:0050832 15 12 0,000 0,03619059 0,06297266 ! developmental induction GO:0031128 22 12 0,000 0,03619059 0,06292784 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,03619059 0,06288308 ! response to cold GO:0009409 17 12 0,000 0,03619059 0,06283839 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03619059 0,06279376 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03619059 0,0627492 ! forebrain development GO:0030900 210 98 1,000 0,036599 0,06341231 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,03796657 0,06573518 GO:0060538|skeletal muscle organ development, ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03914723 0,06773136 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03914723 0,06768343 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03914723 0,06763556 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,03914723 0,06758776 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03914723 0,06754003 ! peroxisomal transport GO:0043574 28 13 0,000 0,03914723 0,06749236 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03914723 0,06744477 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,03914723 0,06739724 ! organelle fusion GO:0048284 36 13 0,000 0,03914723 0,06734977 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03914723 0,06730238 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,03914723 0,06725505 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03914723 0,06720779 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03914723 0,06716059 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03914723 0,06711346 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03914723 0,0670664 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03914723 0,0670194 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03914723 0,06697247 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03914723 0,0669256 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03914723 0,0668788 ! methionine metabolic process GO:0006555 31 13 0,000 0,03914723 0,06683206 ! plasma membrane organization GO:0007009 27 13 0,000 0,03914723 0,06678539 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03914723 0,06673879 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03914723 0,06669225 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,03914723 0,06664577 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03914723 0,06659936 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,03914723 0,06655301 ! cytokine metabolic process GO:0042107 24 13 0,000 0,03914723 0,06650673 ! exocrine system development GO:0035272 34 13 0,000 0,03914723 0,06646051 ! asymmetric protein localization GO:0008105 24 13 0,000 0,03914723 0,06641436 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03914723 0,06636827 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03914723 0,06632225 ! L-glutamate transport GO:0015813 30 13 0,000 0,03914723 0,06627629 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03914723 0,06623039 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03914723 0,06618455 ! protein homotetramerization GO:0051289 24 13 0,000 0,03914723 0,06613878 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03914723 0,06609308 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03914723 0,06604743 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,03914723 0,06600185 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03914723 0,06595633 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03914723 0,06591088 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03914723 0,06586548 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03914723 0,06582015 ! histone methylation GO:0016571 29 13 0,000 0,03914723 0,06577488 ! chromatin silencing GO:0006342 29 13 0,000 0,03914723 0,06572968 ! gland morphogenesis GO:0022612 31 13 0,000 0,03914723 0,06568453 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03914723 0,06563945 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03914723 0,06559443 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03914723 0,06554947 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03914723 0,06550458 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03914723 0,06545974 ! spleen development GO:0048536 24 13 0,000 0,03914723 0,06541497 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,03914723 0,06537025 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03914723 0,0653256 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03914723 0,06528101 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03914723 0,06523648 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03914723 0,06519201 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03914723 0,0651476 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03914723 0,06510325 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03914723 0,06505897 ! insulin secretion GO:0030073 24 13 0,000 0,03914723 0,06501474 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03914723 0,06497057 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,03914723 0,06492646 ! acrosome reaction GO:0007340 19 13 0,000 0,03914723 0,06488242 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03914723 0,06483843 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03914723 0,0647945 ! rRNA transcription GO:0009303 28 14 0,000 0,04209488 0,06962613 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04209488 0,06957902 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04209488 0,06953197 ! water transport GO:0006833 21 14 0,000 0,04209488 0,06948499 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04209488 0,06943808 ! non-recombinational repair GO:0000726 29 14 0,000 0,04209488 0,06939122 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04209488 0,06934443 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04209488 0,0692977 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04209488 0,06925104 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04209488 0,06920443 ! lipid localization GO:0010876 32 14 0,000 0,04209488 0,06915789 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04209488 0,06911142 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04209488 0,069065 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04209488 0,06901865 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04209488 0,06897236 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04209488 0,06892613 ! arginine metabolic process GO:0006525 21 14 0,000 0,04209488 0,06887997 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04209488 0,06883386 ! regulation of heart rate GO:0002027 25 14 0,000 0,04209488 0,06878782 ! fear response GO:0042596 34 14 0,000 0,04209488 0,06874184 ! organic alcohol transport GO:0015850 29 14 0,000 0,04209488 0,06869592 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04209488 0,06865006 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,04209488 0,06860426 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04209488 0,06855853 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04209488 0,06851285 ! bone mineralization GO:0030282 18 14 0,000 0,04209488 0,06846724 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04209488 0,06842168 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,04209488 0,06837619 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04209488 0,06833076 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04209488 0,06828538 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04209488 0,06824007 ! regulation of cellular pH GO:0030641 27 14 0,000 0,04209488 0,06819482 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04209488 0,06814963 ! ribosome assembly GO:0042255 18 14 0,000 0,04209488 0,0681045 ! cerebellum development GO:0021549 23 14 0,000 0,04209488 0,06805942 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04209488 0,06801441 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04209488 0,06796946 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04209488 0,06792456 ! response to gamma radiation GO:0010332 30 14 0,000 0,04209488 0,06787973 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04209488 0,06783495 ! NADP metabolic process GO:0006739 24 14 0,000 0,04209488 0,06779024 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04209488 0,06774558 ! oxygen transport GO:0015671 22 14 0,000 0,04209488 0,06770098 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04209488 0,06765644 ! male genitalia development GO:0030539 26 14 0,000 0,04209488 0,06761196 ! regulation of axon extension GO:0030516 43 14 0,000 0,04209488 0,06756754 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,04209488 0,06752317 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04209488 0,06747886 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04209488 0,06743462 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04503357 0,07209503 ! lactation GO:0007595 30 15 0,000 0,04503357 0,07204781 ! reproductive cellular process GO:0048610 22 15 0,000 0,04503357 0,07200066 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,04503357 0,07195357 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,04503357 0,07190654 ! superoxide anion generation GO:0042554 22 15 0,000 0,04503357 0,07185957 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,04503357 0,07181267 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,04503357 0,07176582 ! copper ion transport GO:0006825 22 15 0,000 0,04503357 0,07171904 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,04503357 0,07167232 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,04503357 0,07162566 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,04503357 0,07157906 ! sulfate transport GO:0008272 27 15 0,000 0,04503357 0,07153252 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,04503357 0,07148604 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,04503357 0,07143962 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,04503357 0,07139326 ! response to hexose stimulus GO:0009746 25 15 0,000 0,04503357 0,07134696 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,04503357 0,07130072 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,04503357 0,07125454 ! vesicle coating GO:0006901 38 15 0,000 0,04503357 0,07120842 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,04503357 0,07116236 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,04503357 0,07111636 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,04503357 0,07107042 ! regulation of exocytosis GO:0017157 26 15 0,000 0,04503357 0,07102454 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,04503357 0,07097872 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,04503357 0,07093295 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,04503357 0,07088725 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,04503357 0,0708416 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,04503357 0,07079602 ! regulation of vasodilation GO:0042312 27 15 0,000 0,04503357 0,07075049 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,04503357 0,07070502 ! histone deacetylation GO:0016575 24 15 0,000 0,04503357 0,07065961 ! water homeostasis GO:0030104 28 15 0,000 0,04503357 0,07061425 ! cofactor transport GO:0051181 30 15 0,000 0,04503357 0,07056896 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,04503357 0,07052372 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,04503357 0,07047855 ! intestinal absorption GO:0050892 31 15 0,000 0,04503357 0,07043342 ! dopamine metabolic process GO:0042417 35 15 0,000 0,04503357 0,07038836 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,04503357 0,07034336 ! heme biosynthetic process GO:0006783 33 15 0,000 0,04503357 0,07029841 ! cell killing GO:0001906 32 15 0,000 0,04503357 0,07025352 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,04503357 0,07020868 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,04503357 0,07016391 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,04503357 0,07011919 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,04503357 0,07007453 ! actin filament polymerization GO:0030041 27 15 0,000 0,04503357 0,07002992 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,04503357 0,06998537 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04796333 0,07449104 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04796333 0,07444371 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04796333 0,07439645 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04796333 0,07434924 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04796333 0,0743021 ! bone remodeling GO:0046849 28 16 0,000 0,04796333 0,07425501 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,04796333 0,07420798 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04796333 0,07416102 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04796333 0,07411411 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04796333 0,07406726 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04796333 0,07402047 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04796333 0,07397374 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04796333 0,07392707 ! startle response GO:0001964 28 16 0,000 0,04796333 0,07388046 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04796333 0,0738339 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04796333 0,07378741 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04796333 0,07374097 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04796333 0,07369459 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04796333 0,07364828 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04796333 0,07360201 ! pituitary gland development GO:0021983 30 16 0,000 0,04796333 0,07355581 ! response to osmotic stress GO:0006970 27 16 0,000 0,04796333 0,07350966 ! lysosomal transport GO:0007041 31 16 0,000 0,04796333 0,07346358 ! fructose metabolic process GO:0006000 25 16 0,000 0,04796333 0,07341755 ! L-amino acid transport GO:0015807 33 16 0,000 0,04796333 0,07337158 ! stem cell development GO:0048864 46 16 0,000 0,04796333 0,07332566 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04796333 0,0732798 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04796333 0,073234 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04796333 0,07318826 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04796333 0,07314258 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04796333 0,07309695 ! axon cargo transport GO:0008088 46 16 0,000 0,04796333 0,07305138 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04796333 0,07300586 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04796333 0,0729604 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,04796333 0,072915 ! DNA replication initiation GO:0006270 28 16 0,000 0,04796333 0,07286966 ! neuron recognition GO:0008038 40 16 0,000 0,04796333 0,07282437 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04796333 0,07277913 ! tissue regeneration GO:0042246 27 16 0,000 0,04796333 0,07273396 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04796333 0,07268884 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04796333 0,07264377 ! biomineral formation GO:0031214 22 16 0,000 0,04796333 0,07259876 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04796333 0,07255381 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04796333 0,07250891 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04796333 0,07246407 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04796333 0,07241929 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04796333 0,07237456 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04796333 0,07232988 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04796333 0,07228526 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,04796333 0,07224069 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,04796333 0,07219618 ! peptide hormone processing GO:0016486 27 16 0,000 0,04796333 0,07215173 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,05088418 0,07649849 ! metencephalon development GO:0022037 32 17 0,000 0,05088418 0,07645144 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,05088418 0,07640445 ! signal complex assembly GO:0007172 47 17 0,000 0,05088418 0,07635752 ! endothelial cell migration GO:0043542 31 17 0,000 0,05088418 0,07631065 ! gene silencing by RNA GO:0031047 38 17 0,000 0,05088418 0,07626383 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,05088418 0,07621707 ! glial cell development GO:0021782 28 17 0,000 0,05088418 0,07617037 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,05088418 0,07612373 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,05088418 0,07607714 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,05088418 0,07603061 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,05088418 0,07598414 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,05088418 0,07593772 ! myoblast differentiation GO:0045445 50 17 0,000 0,05088418 0,07589136 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,05088418 0,07584505 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,05088418 0,07579881 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,05088418 0,07575262 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,05088418 0,07570648 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,05088418 0,0756604 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,05088418 0,07561438 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,05088418 0,07556842 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,05088418 0,07552251 ! membrane budding GO:0006900 42 17 0,000 0,05088418 0,07547665 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,05088418 0,07543085 ! regulation of protein binding GO:0043393 33 17 0,000 0,05088418 0,07538511 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,05088418 0,07533942 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,05088418 0,07529379 ! genitalia development GO:0048806 32 17 0,000 0,05088418 0,07524821 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,05088418 0,07520269 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,05088418 0,07515722 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,05088418 0,07511181 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,05088418 0,07506645 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,05088418 0,07502115 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,05088418 0,0749759 ! steroid catabolic process GO:0006706 34 17 0,000 0,05088418 0,07493071 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,05088418 0,07488557 ! gas transport GO:0015669 26 17 0,000 0,05088418 0,07484048 ! organic cation transport GO:0015695 32 17 0,000 0,05088418 0,07479545 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,05088418 0,07475048 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,05088418 0,07470556 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,05379615 0,07893333 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,05379615 0,07888595 ! limbic system development GO:0021761 40 18 0,000 0,05379615 0,07883863 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,05379615 0,07879136 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,05379615 0,07874415 ! adult walking behavior GO:0007628 36 18 0,000 0,05379615 0,078697 ! patterning of blood vessels GO:0001569 43 18 0,000 0,05379615 0,07864991 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,05379615 0,07860287 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,05379615 0,07855588 ! centrosome cycle GO:0007098 26 18 0,000 0,05379615 0,07850896 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,05379615 0,07846209 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,05379615 0,07841527 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,05379615 0,07836851 ! glycine metabolic process GO:0006544 30 18 0,000 0,05379615 0,07832181 ! glutamine metabolic process GO:0006541 29 18 0,000 0,05379615 0,07827516 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,05379615 0,07822857 ! DNA integration GO:0015074 32 18 0,000 0,05379615 0,07818203 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,05379615 0,07813555 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,05379615 0,07808912 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,05379615 0,07804275 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,05379615 0,07799643 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,05379615 0,07795017 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,05379615 0,07790397 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,05379615 0,07785782 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,05379615 0,07781172 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,05379615 0,07776568 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,05379615 0,07771969 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,05379615 0,07767375 ! detection of bacterium GO:0016045 22 18 0,000 0,05379615 0,07762788 ! nerve development GO:0021675 34 18 0,000 0,05379615 0,07758205 ! defense response to virus GO:0051607 43 18 0,000 0,05379615 0,07753628 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,05379615 0,07749056 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,05379615 0,0774449 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,05669927 0,08157616 ! positive regulation of translation GO:0045727 31 19 0,000 0,05669927 0,08152814 ! negative regulation of defense response GO:0031348 27 19 0,000 0,05669927 0,08148018 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,05669927 0,08143228 ! neuron maturation GO:0042551 46 19 0,000 0,05669927 0,08138444 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,05669927 0,08133665 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,05669927 0,08128892 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,05669927 0,08124124 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,05669927 0,08119362 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,05669927 0,08114605 ! inositol metabolic process GO:0006020 33 19 0,000 0,05669927 0,08109854 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05669927 0,08105109 ! memory GO:0007613 34 19 0,000 0,05669927 0,08100369 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,05669927 0,08095635 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,05669927 0,08090906 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,05669927 0,08086183 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,05669927 0,08081465 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,05669927 0,08076753 ! cerebral cortex development GO:0021987 40 19 0,000 0,05669927 0,08072046 ! pigmentation during development GO:0048066 42 19 0,000 0,05669927 0,08067345 ! heme metabolic process GO:0042168 40 19 0,000 0,05669927 0,08062649 ! neuromuscular junction development GO:0007528 43 19 0,000 0,05669927 0,08057959 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,05669927 0,08053274 ! response to fungus GO:0009620 26 19 0,000 0,05669927 0,08048595 ! peptide cross-linking GO:0018149 39 19 0,000 0,05669927 0,08043921 ! protein export from nucleus GO:0006611 40 19 0,000 0,05669927 0,08039252 ! heart process GO:0003015 32 19 0,000 0,05669927 0,08034589 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,05669927 0,08029931 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,05669927 0,08025279 ! visual learning GO:0008542 38 19 0,000 0,05669927 0,08020632 ! cellular pigmentation GO:0033059 37 19 0,000 0,05669927 0,0801599 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,05669927 0,08011354 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,05669927 0,08006723 ! vitamin transport GO:0051180 31 19 0,000 0,05669927 0,08002098 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,05669927 0,07997478 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,05669927 0,07992863 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,05669927 0,07988253 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,05669927 0,07983649 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,05669927 0,0797905 ! cilium assembly GO:0042384 38 19 0,000 0,05669927 0,07974457 ! peptide hormone secretion GO:0030072 32 19 0,000 0,05669927 0,07969868 ! protein secretion GO:0009306 45 20 0,000 0,05959356 0,08371885 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,05959356 0,08367073 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,05959356 0,08362267 ! positive regulation of ossification GO:0045778 50 20 0,000 0,05959356 0,08357467 ! skin development GO:0043588 42 20 0,000 0,05959356 0,08352672 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,05959356 0,08347883 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,05959356 0,08343099 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,05959356 0,0833832 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,05959356 0,08333547 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,05959356 0,0832878 ! bile acid metabolic process GO:0008206 34 20 0,000 0,05959356 0,08324018 ! response to alkaloid GO:0043279 38 20 0,000 0,05959356 0,08319261 ! retinoid metabolic process GO:0001523 34 20 0,000 0,05959356 0,0831451 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,05959356 0,08309764 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,05959356 0,08305024 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,05959356 0,08300289 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,05959356 0,0829556 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,05959356 0,08290836 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,05959356 0,08286117 ! body fluid secretion GO:0007589 33 20 0,000 0,05959356 0,08281403 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,05959356 0,08276695 ! peptide secretion GO:0002790 38 20 0,000 0,05959356 0,08271993 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,05959356 0,08267295 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,05959356 0,08262603 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,05959356 0,08257917 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,05959356 0,08253235 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,05959356 0,08248559 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,05959356 0,08243889 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,05959356 0,08239223 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,05959356 0,08234563 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,05959356 0,08229908 ! regulation of glucose import GO:0046324 30 20 0,000 0,05959356 0,08225258 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,05959356 0,08220614 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,05959356 0,08215975 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,05959356 0,08211341 ! negative regulation of translation GO:0017148 32 20 0,000 0,05959356 0,08206712 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,05959356 0,08202089 ! regulation of cell killing GO:0031341 46 21 0,000 0,06247906 0,08594388 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,06247906 0,08589552 ! hormone secretion GO:0046879 39 21 0,000 0,06247906 0,08584721 ! cAMP metabolic process GO:0046058 41 21 0,000 0,06247906 0,08579895 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,06247906 0,08575075 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,06247906 0,0857026 ! ovarian follicle development GO:0001541 39 21 0,000 0,06247906 0,08565451 ! smooth muscle contraction GO:0006939 48 21 0,000 0,06247906 0,08560647 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,06247906 0,08555848 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,06247906 0,08551055 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,06247906 0,08546267 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,06247906 0,08541485 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,06247906 0,08536708 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,06247906 0,08531936 ! sensory perception of pain GO:0019233 33 21 0,000 0,06247906 0,0852717 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,06247906 0,08522408 ! diencephalon development GO:0021536 36 21 0,000 0,06247906 0,08517653 ! collagen fibril organization GO:0030199 62 21 0,000 0,06247906 0,08512902 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,06247906 0,08508157 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,06247906 0,08503417 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,06247906 0,08498682 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,06247906 0,08493953 ! collagen catabolic process GO:0030574 29 21 0,000 0,06247906 0,08489229 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,06247906 0,0848451 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,06247906 0,08479796 ! sperm-egg recognition GO:0035036 23 21 0,000 0,06247906 0,08475088 ! actin filament-based movement GO:0030048 47 21 0,000 0,06247906 0,08470385 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,06247906 0,08465687 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,06535578 0,08850564 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,06535578 0,0884566 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,06535578 0,08840762 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,06535578 0,0883587 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,06535578 0,08830983 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,06535578 0,08826101 ! microtubule-based transport GO:0010970 59 22 0,000 0,06535578 0,08821225 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,06535578 0,08816354 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,06535578 0,08811488 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,06535578 0,08806628 ! cellular response to starvation GO:0009267 37 22 0,000 0,06535578 0,08801773 ! vacuolar transport GO:0007034 41 22 0,000 0,06535578 0,08796924 ! central nervous system neuron development GO:0021954 47 22 0,000 0,06535578 0,0879208 ! fucose metabolic process GO:0006004 44 22 0,000 0,06535578 0,08787241 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,06535578 0,08782407 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,06535578 0,08777579 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,06535578 0,08772756 ! ureteric bud development GO:0001657 50 22 0,000 0,06535578 0,08767939 ! cell aging GO:0007569 48 22 0,000 0,06535578 0,08763127 ! stem cell differentiation GO:0048863 57 22 0,000 0,06535578 0,0875832 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,06535578 0,08753518 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,06535578 0,08748721 ! cytolysis GO:0019835 27 22 0,000 0,06535578 0,0874393 ! renal system process GO:0003014 42 22 0,000 0,06535578 0,08739144 ! vasodilation GO:0042311 40 22 0,000 0,06535578 0,08734364 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,06535578 0,08729588 ! G1 phase GO:0051318 44 22 0,000 0,06535578 0,08724818 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,06535578 0,08720053 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,06535578 0,08715293 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,06535578 0,08710538 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,06535578 0,08705789 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,06535578 0,08701044 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,06535578 0,08696305 ! sarcomere organization GO:0045214 32 22 0,000 0,06535578 0,08691571 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,06535578 0,08686843 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,06535578 0,08682119 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,06535578 0,086774 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,06535578 0,08672687 ! gut development GO:0048565 44 22 0,000 0,06535578 0,08667979 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,06535578 0,08663275 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,06535578 0,08658577 ! protein stabilization GO:0050821 41 22 0,000 0,06535578 0,08653884 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06822375 0,09028745 ! gluconeogenesis GO:0006094 38 23 0,000 0,06822375 0,09023857 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06822375 0,09018973 ! viral genome replication GO:0019079 44 23 0,000 0,06822375 0,09014096 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06822375 0,09009223 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06822375 0,09004356 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06822375 0,08999494 ! regeneration GO:0031099 42 23 0,000 0,06822375 0,08994637 ! axis specification GO:0009798 43 23 0,000 0,06822375 0,08989786 ! visual behavior GO:0007632 46 23 0,000 0,06822375 0,0898494 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06822375 0,08980099 ! response to ethanol GO:0045471 47 23 0,000 0,06822375 0,08975263 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06822375 0,08970432 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,06822375 0,08965607 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06822375 0,08960787 ! peroxisome organization GO:0007031 43 23 0,000 0,06822375 0,08955972 ! lysosome organization GO:0007040 47 23 0,000 0,06822375 0,08951162 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,06822375 0,08946357 ! vesicle targeting GO:0006903 49 23 0,000 0,06822375 0,08941557 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,06822375 0,08936763 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06822375 0,08931974 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06822375 0,0892719 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06822375 0,08922411 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06822375 0,08917637 ! DNA modification GO:0006304 36 23 0,000 0,06822375 0,08912868 ! fatty acid transport GO:0015908 47 23 0,000 0,06822375 0,08908104 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,06822375 0,08903346 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06822375 0,08898592 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06822375 0,08893844 ! hormone transport GO:0009914 41 23 0,000 0,06822375 0,088891 ! cell-cell recognition GO:0009988 28 23 0,000 0,06822375 0,08884362 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06822375 0,08879629 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,06822375 0,088749 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,07108301 0,09241926 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,07108301 0,0923701 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,07108301 0,09232099 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,07108301 0,09227194 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,07108301 0,09222294 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,07108301 0,09217399 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,07108301 0,09212509 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,07108301 0,09207624 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,07108301 0,09202745 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,07108301 0,0919787 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,07108301 0,09193001 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,07108301 0,09188137 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,07108301 0,09183278 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,07108301 0,09178424 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,07108301 0,09173576 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,07108301 0,09168732 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,07108301 0,09163894 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,07108301 0,09159061 ! membrane depolarization GO:0051899 45 24 0,000 0,07108301 0,09154233 ! pallium development GO:0021543 56 24 0,000 0,07108301 0,09149409 ! oogenesis GO:0048477 44 24 0,000 0,07108301 0,09144591 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,07108301 0,09139778 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,07108301 0,09134971 ! platelet activation GO:0030168 41 24 0,000 0,07108301 0,09130168 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,07108301 0,0912537 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,07108301 0,09120577 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,07108301 0,0911579 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,07108301 0,09111007 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,07108301 0,09106229 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,07108301 0,09101457 ! regulation of amine transport GO:0051952 41 24 0,000 0,07108301 0,09096689 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,07108301 0,09091926 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,07393357 0,09451581 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,07393357 0,09446638 ! leukocyte adhesion GO:0007159 55 25 0,000 0,07393357 0,094417 ! phototransduction GO:0007602 37 25 0,000 0,07393357 0,09436767 ! keratinization GO:0031424 37 25 0,000 0,07393357 0,09431839 ! vacuole organization GO:0007033 49 25 0,000 0,07393357 0,09426916 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,07393357 0,09421999 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,07393357 0,09417086 ! receptor metabolic process GO:0043112 53 25 0,000 0,07393357 0,09412179 ! chromosome condensation GO:0030261 48 25 0,000 0,07393357 0,09407277 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,07393357 0,0940238 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,07393357 0,09397488 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,07393357 0,09392601 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,07393357 0,09387719 ! immunoglobulin production GO:0002377 62 25 0,000 0,07393357 0,09382842 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,07393357 0,09377971 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,07393357 0,09373104 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,07393357 0,09368242 ! liver development GO:0001889 55 25 0,000 0,07393357 0,09363386 ! myelination GO:0042552 50 26 0,000 0,07677546 0,09718262 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,07677546 0,09713229 ! molting cycle process GO:0022404 52 26 0,000 0,07677546 0,09708202 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,07677546 0,0970318 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,07677546 0,09698162 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,07677546 0,0969315 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,07677546 0,09688144 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,07677546 0,09683142 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,07677546 0,09678146 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,07677546 0,09673154 ! digestive system process GO:0022600 49 26 0,000 0,07677546 0,09668168 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,07677546 0,09663187 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,07677546 0,09658211 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,07677546 0,0965324 ! negative regulation of cell development GO:0010721 83 26 0,000 0,07677546 0,09648275 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,07677546 0,09643314 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,07677546 0,09638359 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,07677546 0,09633408 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,07677546 0,09628463 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,07677546 0,09623523 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,07677546 0,09618588 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,07677546 0,09613658 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,07677546 0,09608733 ! blastocyst development GO:0001824 50 26 0,000 0,07677546 0,09603813 ! telomere organization GO:0032200 46 26 0,000 0,07677546 0,09598898 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,07677546 0,09593988 ! alditol metabolic process GO:0019400 44 26 0,000 0,07677546 0,09589083 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,07677546 0,09584183 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,07677546 0,09579288 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,07960872 0,09927723 ! embryonic pattern specification GO:0009880 49 27 0,000 0,07960872 0,09922658 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,07960872 0,09917598 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,07960872 0,09912543 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,07960872 0,09907493 ! iron ion transport GO:0006826 65 27 0,000 0,07960872 0,09902449 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,07960872 0,0989741 ! superoxide metabolic process GO:0006801 41 27 0,000 0,07960872 0,09892375 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,07960872 0,09887346 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,07960872 0,09882322 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,07960872 0,09877303 ! response to starvation GO:0042594 47 27 0,000 0,07960872 0,09872289 ! response to toxin GO:0009636 49 27 0,000 0,07960872 0,0986728 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,07960872 0,09862277 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,07960872 0,09857278 ! leukocyte proliferation GO:0070661 59 27 0,000 0,07960872 0,09852285 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,07960872 0,09847296 ! neuron fate commitment GO:0048663 52 28 0,000 0,08243336 0,10191533 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,08243336 0,10186378 ! vesicle docking GO:0048278 55 28 0,000 0,08243336 0,10181228 ! circadian rhythm GO:0007623 56 28 0,000 0,08243336 0,10176083 ! dendrite development GO:0016358 67 28 0,000 0,08243336 0,10170944 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,08243336 0,1016581 ! fat cell differentiation GO:0045444 57 28 0,000 0,08243336 0,1016068 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,08243336 0,10155557 ! sperm motility GO:0030317 37 28 0,000 0,08243336 0,10150438 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,08243336 0,10145324 ! base-excision repair GO:0006284 41 28 0,000 0,08243336 0,10140216 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,08243336 0,10135113 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,08243336 0,10130014 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,08243336 0,10124921 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,08243336 0,10119833 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,08243336 0,10114751 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,08243336 0,10109673 ! glutathione metabolic process GO:0006749 42 28 0,000 0,08243336 0,101046 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,08243336 0,10099533 ! lipid oxidation GO:0034440 48 28 0,000 0,08243336 0,10094471 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,08243336 0,10089413 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,08243336 0,10084361 ! translational initiation GO:0006413 66 29 0,000 0,0852494 0,10423638 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,0852494 0,10418424 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,0852494 0,10413215 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,0852494 0,10408011 ! autophagy GO:0006914 47 29 0,000 0,0852494 0,10402812 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,0852494 0,10397618 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,0852494 0,1039243 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,0852494 0,10387246 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,0852494 0,10382068 ! synaptogenesis GO:0007416 46 29 0,000 0,0852494 0,10376895 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,0852494 0,10371728 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,0852494 0,10366565 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,0852494 0,10361408 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,08805689 0,10697314 ! phenol metabolic process GO:0018958 56 30 0,000 0,08805689 0,10691997 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,08805689 0,10686685 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,08805689 0,10681379 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,08805689 0,10676078 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,08805689 0,10670783 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,08805689 0,10665492 ! acute-phase response GO:0006953 50 30 0,000 0,08805689 0,10660207 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,08805689 0,10654927 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,08805689 0,10649652 ! myofibril assembly GO:0030239 50 30 0,000 0,08805689 0,10644383 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,08805689 0,10639119 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,08805689 0,10633859 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,08805689 0,10628606 ! cell fate determination GO:0001709 64 30 0,000 0,08805689 0,10623357 ! phospholipid transport GO:0015914 65 30 0,000 0,08805689 0,10618113 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,08805689 0,10612875 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,08805689 0,10607642 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,08805689 0,10602414 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,08805689 0,10597191 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,08805689 0,10591973 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,08805689 0,10586761 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,09085583 0,10917895 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,09085583 0,10912527 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,09085583 0,10907165 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,09085583 0,10901808 ! regulation of innate immune response GO:0045088 57 31 0,000 0,09085583 0,10896456 ! ovulation cycle process GO:0022602 55 31 0,000 0,09085583 0,10891109 ! peptide transport GO:0015833 60 31 0,000 0,09085583 0,10885768 ! male gonad development GO:0008584 56 31 0,000 0,09085583 0,10880432 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,09085583 0,10875101 ! detection of light stimulus GO:0009583 44 31 0,000 0,09085583 0,10869775 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,09085583 0,10864454 ! natural killer cell activation GO:0030101 50 31 0,000 0,09085583 0,10859139 ! ensheathment of neurons GO:0007272 64 31 0,000 0,09085583 0,10853829 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,09085583 0,10848524 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,09085583 0,10843224 ! eye morphogenesis GO:0048592 65 31 0,000 0,09085583 0,1083793 ! response to heat GO:0009408 54 31 0,000 0,09085583 0,10832641 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,09085583 0,10827356 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,09364627 0,11154453 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,09364627 0,11149017 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,09364627 0,11143587 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,09364627 0,11138161 ! metanephros development GO:0001656 81 32 0,000 0,09364627 0,11132741 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,09364627 0,11127327 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,09364627 0,11121917 ! muscle cell development GO:0055001 52 32 0,000 0,09364627 0,11116513 ! mesoderm formation GO:0001707 73 32 0,000 0,09364627 0,11111114 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,09364627 0,1110572 ! ovulation cycle GO:0042698 57 32 0,000 0,09364627 0,11100332 ! peripheral nervous system development GO:0007422 68 32 0,000 0,09364627 0,11094948 ! BMP signaling pathway GO:0030509 71 32 0,000 0,09364627 0,1108957 ! hindbrain development GO:0030902 65 32 0,000 0,09364627 0,11084198 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,09364627 0,1107883 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,09364627 0,11073467 ! gene silencing GO:0016458 71 32 0,000 0,09364627 0,1106811 ! regulation of pH GO:0006885 56 33 0,000 0,09642822 0,11391399 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,09642822 0,11385894 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,09642822 0,11380393 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,09642822 0,11374898 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,09642822 0,11369408 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,09642822 0,11363924 ! response to ionizing radiation GO:0010212 74 33 0,000 0,09642822 0,11358444 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,09642822 0,1135297 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,09642822 0,11347502 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,09642822 0,11342038 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,09642822 0,1133658 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,09642822 0,11331127 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,09642822 0,1132568 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,09642822 0,11320237 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,09920171 0,11640239 ! glial cell differentiation GO:0010001 67 34 0,000 0,09920171 0,1163465 ! post-embryonic development GO:0009791 76 34 0,000 0,09920171 0,11629068 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,09920171 0,1162349 ! cholesterol transport GO:0030301 62 34 0,000 0,09920171 0,11617918 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,09920171 0,11612351 ! spliceosome assembly GO:0000245 75 34 0,000 0,09920171 0,1160679 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,09920171 0,11601233 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,09920171 0,11595683 ! formation of primary germ layer GO:0001704 76 34 0,000 0,09920171 0,11590137 ! cell fate specification GO:0001708 56 34 0,000 0,09920171 0,11584597 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,09920171 0,11579062 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,09920171 0,11573532 ! adult locomotory behavior GO:0008344 62 34 0,000 0,09920171 0,11568008 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,10196676 0,11884771 ! negative regulation of secretion GO:0051048 68 35 0,000 0,10196676 0,11879103 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,10196676 0,11873441 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,10196676 0,11867784 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,10196676 0,11862133 ! membrane docking GO:0022406 69 35 0,000 0,10196676 0,11856487 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,10196676 0,11850846 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,10196676 0,11845211 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,10196676 0,11839581 ! ceramide metabolic process GO:0006672 72 35 0,000 0,10196676 0,11833957 ! telencephalon development GO:0021537 81 35 0,000 0,10196676 0,11828338 ! sterol transport GO:0015918 63 35 0,000 0,10196676 0,11822724 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,10196676 0,11817115 ! vesicle localization GO:0051648 70 35 0,000 0,10196676 0,11811512 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,1047234 0,12125084 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,1047234 0,1211934 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,1047234 0,12113602 ! positive regulation of cell development GO:0010720 85 36 0,000 0,1047234 0,12107869 ! protein targeting to membrane GO:0006612 75 36 0,000 0,1047234 0,12102141 ! regulation of proteolysis GO:0030162 77 36 0,000 0,1047234 0,12096419 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,1047234 0,12090703 ! cytokine production GO:0001816 68 36 0,000 0,1047234 0,12084991 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,1047234 0,12079286 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,1047234 0,12073585 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,10747166 0,12384588 ! odontogenesis GO:0042476 74 37 0,000 0,10747166 0,12378749 ! actomyosin structure organization GO:0031032 68 37 0,000 0,10747166 0,12372915 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,10747166 0,12367087 ! female gonad development GO:0008585 71 37 0,000 0,10747166 0,12361265 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,10747166 0,12355448 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,10747166 0,12349636 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,10747166 0,1234383 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,10747166 0,12338029 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,11021156 0,12646634 ! organic anion transport GO:0015711 82 38 0,000 0,11021156 0,12640697 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,11021156 0,12634765 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,11021156 0,12628838 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,11021156 0,12622918 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,11021156 0,12617003 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,11021156 0,12611093 ! regulation of protein stability GO:0031647 77 38 0,000 0,11021156 0,12605189 ! spermatid development GO:0007286 69 38 0,000 0,11021156 0,1259929 ! glycogen metabolic process GO:0005977 63 38 0,000 0,11021156 0,12593397 ! pigment metabolic process GO:0042440 87 38 0,000 0,11021156 0,1258751 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,11294312 0,1289346 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,11294312 0,12887438 ! negative regulation of binding GO:0051100 71 39 0,000 0,11294312 0,12881422 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,11294312 0,12875411 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,11294312 0,12869405 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,11294312 0,12863406 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,11294312 0,12857411 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,11294312 0,12851423 ! glucan metabolic process GO:0044042 64 39 0,000 0,11294312 0,1284544 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,11566638 0,13149044 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,11566638 0,13142929 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,11566638 0,13136818 ! learning GO:0007612 82 40 0,000 0,11566638 0,13130714 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,11566638 0,13124615 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,11566638 0,13118522 ! lipid homeostasis GO:0055088 75 40 0,000 0,11566638 0,13112434 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,11566638 0,13106353 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,11566638 0,13100276 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,11566638 0,13094206 ! RNA export from nucleus GO:0006405 61 41 0,000 0,11838135 0,13395352 ! mRNA catabolic process GO:0006402 79 41 0,000 0,11838135 0,1338915 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,11838135 0,13382954 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,11838135 0,13376764 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,11838135 0,1337058 ! gliogenesis GO:0042063 91 41 0,000 0,11838135 0,13364401 ! feeding behavior GO:0007631 69 41 0,000 0,11838135 0,13358228 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,11838135 0,13352061 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,11838135 0,13345899 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,11838135 0,13339744 ! spermatid differentiation GO:0048515 73 41 0,000 0,11838135 0,13333593 ! RNA modification GO:0009451 64 41 0,000 0,11838135 0,13327449 ! ear morphogenesis GO:0042471 64 42 0,000 0,12108806 0,13625893 ! organic ether metabolic process GO:0018904 59 42 0,000 0,12108806 0,1361962 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,12108806 0,13613352 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,12108806 0,1360709 ! T cell differentiation GO:0030217 93 42 0,000 0,12108806 0,13600834 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,12108806 0,13594584 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,12108806 0,13588339 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,12108806 0,135821 ! regulation of protein secretion GO:0050708 77 42 0,000 0,12108806 0,13575867 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,12108806 0,13569639 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,12108806 0,13563418 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,12378654 0,13859327 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,12378654 0,13852979 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,12378654 0,13846636 ! regulation of tube size GO:0035150 76 43 0,000 0,12378654 0,13840299 GO:0050880|regulation of blood vessel size, ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,12378654 0,13833967 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,12378654 0,13827642 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,12378654 0,13821322 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,12378654 0,13815008 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,12378654 0,138087 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,12378654 0,13802397 ! ion transmembrane transport GO:0034220 79 43 0,000 0,12378654 0,13796101 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,12647681 0,14089505 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,12647681 0,14083084 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,12647681 0,14076668 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,12647681 0,14070257 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,12647681 0,14063853 ! striated muscle contraction GO:0006941 85 44 0,000 0,12647681 0,14057455 ! phagocytosis GO:0006909 105 44 0,000 0,12647681 0,14051062 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,12647681 0,14044675 ! double-strand break repair GO:0006302 85 44 0,000 0,12647681 0,14038294 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,1291589 0,14329482 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,1291589 0,14322977 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,1291589 0,14316479 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,1291589 0,14309986 ! biopolymer methylation GO:0043414 91 45 0,000 0,1291589 0,14303499 ! B cell differentiation GO:0030183 124 45 0,000 0,1291589 0,14297018 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,1291589 0,14290543 ! female gamete generation GO:0007292 71 45 0,000 0,1291589 0,14284074 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,1291589 0,1427761 ! polyol metabolic process GO:0019751 77 45 0,000 0,1291589 0,14271153 ! developmental growth GO:0048589 88 45 0,000 0,1291589 0,14264701 ! maintenance of location in cell GO:0051651 101 45 0,000 0,1291589 0,14258255 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,13183282 0,14546865 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,13183282 0,14540297 ! leukocyte migration GO:0050900 75 46 0,000 0,13183282 0,14533736 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,13183282 0,1452718 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,13183282 0,14520631 ! pigmentation GO:0043473 103 46 0,000 0,13183282 0,14514087 ! cell growth GO:0016049 90 46 0,000 0,13183282 0,14507549 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,13183282 0,14501017 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,13449861 0,14787584 ! positive regulation of defense response GO:0031349 88 48 0,000 0,13715629 0,15073002 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,13715629 0,15066224 ! mitochondrial transport GO:0006839 94 48 0,000 0,13715629 0,15059453 ! cellular component disassembly GO:0022411 89 48 0,000 0,13715629 0,15052688 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,13715629 0,15045928 ! endosome transport GO:0016197 127 48 0,000 0,13715629 0,15039175 ! male sex differentiation GO:0046661 93 48 0,000 0,13715629 0,15032428 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,13715629 0,15025687 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,13715629 0,15018952 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,13715629 0,15012223 ! methylation GO:0032259 97 48 0,000 0,13715629 0,150055 ! response to calcium ion GO:0051592 94 49 0,000 0,13980589 0,15288531 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,13980589 0,1528169 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,13980589 0,15274856 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,13980589 0,15268028 ! JNK cascade GO:0007254 106 49 0,000 0,13980589 0,15261206 ! protein homooligomerization GO:0051260 84 49 0,000 0,13980589 0,15254389 ! regulation of action potential GO:0001508 102 50 0,000 0,14244742 0,15535671 ! regulation of ion transport GO:0043269 86 50 0,000 0,14244742 0,15528739 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,14244742 0,15521813 ! endocrine system development GO:0035270 109 50 0,000 0,14244742 0,15514893 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,14244742 0,15507979 ! activation of caspase activity GO:0006919 95 50 0,000 0,14244742 0,15501071 ! regulation of ossification GO:0030278 123 50 0,000 0,14244742 0,15494169 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,14244742 0,15487274 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,14244742 0,15480384 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,14244742 0,15473501 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,14244742 0,15466624 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,14508091 0,15745565 ! peptide metabolic process GO:0006518 80 51 0,000 0,14508091 0,15738573 ! response to temperature stimulus GO:0009266 84 51 0,000 0,14508091 0,15731588 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,14508091 0,15724608 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,14508091 0,15717635 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,14770639 0,15994979 ! Notch signaling pathway GO:0007219 111 52 0,000 0,14770639 0,15987892 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,14770639 0,15980811 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,14770639 0,15973737 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,14770639 0,15966669 ! excretion GO:0007588 87 52 0,000 0,14770639 0,15959607 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,14770639 0,15952552 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,14770639 0,15945502 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,14770639 0,15938459 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,14770639 0,15931422 ! amino acid activation GO:0043038 98 52 0,000 0,14770639 0,15924392 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,15032388 0,16199437 ! inner ear development GO:0048839 89 53 0,000 0,15032388 0,16192295 ! chromatin remodeling GO:0006338 122 53 0,000 0,15032388 0,16185159 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,15032388 0,16178029 ! vesicle organization GO:0016050 127 53 0,000 0,15032388 0,16170905 ! synapse organization GO:0050808 102 53 0,000 0,15032388 0,16163787 ! regulation of translational initiation GO:0006446 87 54 0,000 0,15293341 0,16437146 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,15293341 0,16429917 ! neuromuscular process GO:0050905 107 54 0,000 0,15293341 0,16422695 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,15293341 0,1641548 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,15293341 0,16408271 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,15293341 0,16401068 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,15293341 0,16393871 ! RNA catabolic process GO:0006401 103 55 0,000 0,15553499 0,16665438 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,15553499 0,16658132 ! cell recognition GO:0008037 98 55 0,000 0,15553499 0,16650832 ! cell maturation GO:0048469 107 55 0,000 0,15553499 0,16643539 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,15812866 0,16913674 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,15812866 0,16906272 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,15812866 0,16898877 ! RNA elongation GO:0006354 90 56 0,000 0,15812866 0,16891488 ! chloride transport GO:0006821 102 57 0,000 0,16071444 0,171602 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,16071444 0,17152703 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 0,000 0,16071444 0,17145213 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,16071444 0,17137729 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,16071444 0,17130252 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,16329234 0,17397435 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,16329234 0,17389852 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,16329234 0,17382274 ! aging GO:0007568 112 58 0,000 0,16329234 0,17374704 ! gastrulation GO:0007369 122 58 0,000 0,16329234 0,17367139 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,16329234 0,17359582 ! maintenance of location GO:0051235 124 58 0,000 0,16329234 0,17352031 ! nuclear export GO:0051168 110 59 0,000 0,1658624 0,17617472 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,16842464 0,17881851 ! DNA catabolic process GO:0006308 94 60 0,000 0,16842464 0,17874083 ! regulation of endocytosis GO:0030100 104 60 0,000 0,16842464 0,17866322 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,16842464 0,17858568 ! adult behavior GO:0030534 104 60 0,000 0,16842464 0,1785082 ! kidney development GO:0001822 133 60 0,000 0,16842464 0,17843079 ! positive regulation of secretion GO:0051047 110 61 0,000 0,17097908 0,18105847 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,17097908 0,18098002 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,17097908 0,18090164 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,17097908 0,18082333 ! regulation of heart contraction GO:0008016 123 61 0,000 0,17097908 0,18074508 ! camera-type eye development GO:0043010 126 61 0,000 0,17097908 0,18066691 ! proton transport GO:0015992 117 61 0,000 0,17097908 0,1805888 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,17097908 0,18051076 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,17352574 0,18312026 ! tRNA processing GO:0008033 102 62 0,000 0,17352574 0,18304119 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,17606466 0,18563917 ! hydrogen transport GO:0006818 121 64 0,000 0,17859584 0,18822676 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,17859584 0,1881456 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,18111932 0,19072177 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,18111932 0,19063959 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,18111932 0,19055749 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,18111932 0,19047546 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,18111932 0,1903935 ! ear development GO:0043583 114 66 0,000 0,18363512 0,19295509 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,18363512 0,19287214 ! gonad development GO:0008406 115 66 0,000 0,18363512 0,19278925 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,18363512 0,19270644 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,18614326 0,19525461 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,18614326 0,19517081 ! secondary metabolic process GO:0019748 125 67 0,000 0,18614326 0,19508708 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,18864376 0,19762295 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,18864376 0,19753824 ! extracellular matrix organization GO:0030198 146 68 0,000 0,18864376 0,1974536 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,18864376 0,19736904 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,18864376 0,19728455 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,18864376 0,19720013 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,18864376 0,19711579 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,19113665 0,19963525 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,19113665 0,19954993 ! urogenital system development GO:0001655 149 69 0,000 0,19113665 0,19946469 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,19113665 0,19937952 ! developmental maturation GO:0021700 128 69 0,000 0,19113665 0,19929443 ! single fertilization GO:0007338 83 69 0,000 0,19113665 0,1992094 ! cell redox homeostasis GO:0045454 114 70 0,000 0,19362196 0,20171362 ! germ cell development GO:0007281 133 70 0,000 0,19362196 0,20162764 ! activation of immune response GO:0002253 120 70 0,000 0,19362196 0,20154173 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,19362196 0,20145589 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,19609969 0,20394702 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,19609969 0,20386023 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,19609969 0,20377352 ! B cell activation GO:0042113 179 72 0,000 0,19856988 0,20625265 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,19856988 0,20616499 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,19856988 0,20607741 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,19856988 0,2059899 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,19856988 0,20590247 ! humoral immune response GO:0006959 115 73 0,000 0,20103256 0,20836764 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,20103256 0,20827928 ! regulation of immune effector process GO:0002697 156 73 0,000 0,20103256 0,20819098 ! acute inflammatory response GO:0002526 118 74 0,000 0,20348773 0,21064429 ! amino acid transport GO:0006865 148 74 0,000 0,20348773 0,21055507 ! regulation of caspase activity GO:0043281 136 74 0,000 0,20348773 0,21046593 ! transition metal ion transport GO:0000041 143 75 0,000 0,20593543 0,21290743 ! reproductive structure development GO:0048608 131 75 0,000 0,20593543 0,21281736 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,20593543 0,21272738 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,20593543 0,21263747 ! eye development GO:0001654 155 75 0,000 0,20593543 0,21254763 ! axon guidance GO:0007411 162 75 0,000 0,20593543 0,21245787 ! rhythmic process GO:0048511 142 75 0,000 0,20593543 0,21236819 ! learning or memory GO:0007611 161 76 0,000 0,20837567 0,21479399 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,20837567 0,2147034 ! regulation of blood pressure GO:0008217 134 76 0,000 0,20837567 0,21461289 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,20837567 0,21452245 ! neurotransmitter transport GO:0006836 142 77 0,000 0,21080849 0,21693561 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,21080849 0,21684426 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,21080849 0,216753 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,21080849 0,21666181 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,21080849 0,2165707 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,21323389 0,21897032 ! antigen processing and presentation GO:0019882 117 78 0,000 0,21323389 0,21887832 ! fertilization GO:0009566 99 78 0,000 0,21323389 0,21878639 ! blood coagulation GO:0007596 151 79 0,000 0,21565191 0,22117448 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,21565191 0,22108167 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,21565191 0,22098893 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,21565191 0,22089628 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,21806257 0,22327194 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,21806257 0,22317841 ! muscle cell differentiation GO:0042692 178 81 0,000 0,22046588 0,22554362 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,22046588 0,22544921 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,22286188 0,22780401 ! protein import into nucleus GO:0006606 174 82 0,000 0,22286188 0,22770873 ! exocytosis GO:0006887 153 83 0,000 0,22525058 0,23005316 ! response to drug GO:0042493 149 83 0,000 0,22525058 0,22995703 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,22525058 0,22986097 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,22525058 0,229765 ! nuclear import GO:0051170 177 83 0,000 0,22525058 0,2296691 ! inorganic anion transport GO:0015698 156 83 0,000 0,22525058 0,22957329 ! response to metal ion GO:0010038 158 84 0,000 0,227632 0,23190366 ! T cell activation GO:0042110 189 84 0,000 0,227632 0,231807 ! digestion GO:0007586 130 84 0,000 0,227632 0,23171041 ! regulation of ligase activity GO:0051340 147 84 0,000 0,227632 0,2316139 ! hemostasis GO:0007599 165 85 0,000 0,23000617 0,23393218 ! negative regulation of transport GO:0051051 164 85 0,000 0,23000617 0,23383483 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,23000617 0,23373756 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,23000617 0,23364037 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,23000617 0,23354326 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,23473285 0,2382436 ! mitochondrion organization GO:0007005 159 87 0,000 0,23473285 0,23814466 ! nucleosome assembly GO:0006334 126 87 0,000 0,23473285 0,2380458 ! regulation of protein transport GO:0051223 165 87 0,000 0,23473285 0,23794703 GO:0070201|regulation of establishment of protein localization, ! amine biosynthetic process GO:0009309 146 88 0,000 0,23708539 0,2402321 ! sensory perception of smell GO:0007608 117 88 0,000 0,23708539 0,24013251 ! chromatin assembly GO:0031497 128 88 0,000 0,23708539 0,24003299 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,23708539 0,23993356 ! cellular defense response GO:0006968 123 89 0,000 0,23943077 0,24220677 ! protein localization in nucleus GO:0034504 192 89 0,000 0,23943077 0,24210652 ! regulation of neurological system process GO:0031644 175 89 0,000 0,23943077 0,24200636 ! response to inorganic substance GO:0010035 173 90 0,000 0,241769 0,24426868 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,241769 0,2441677 ! response to unfolded protein GO:0006986 139 90 0,000 0,241769 0,2440668 ! gland development GO:0048732 220 91 0,000 0,24410011 0,24631828 ! defense response to bacterium GO:0042742 112 91 0,000 0,24410011 0,24621658 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,24642412 0,24845816 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,24874105 0,25069075 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,24874105 0,25058737 ! vitamin metabolic process GO:0006766 153 93 0,000 0,24874105 0,25048408 ! female pregnancy GO:0007565 166 94 0,000 0,25105092 0,25270597 ! sterol metabolic process GO:0016125 166 94 0,000 0,25105092 0,25260189 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,25105092 0,2524979 ! regulation of membrane potential GO:0042391 179 94 0,000 0,25105092 0,25239399 ! regulation of defense response GO:0031347 171 95 0,000 0,25335375 0,25460437 ! nucleosome organization GO:0034728 143 95 0,000 0,25335375 0,25449968 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,25335375 0,25439507 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,25335375 0,25429056 ! sex differentiation GO:0007548 171 96 0,000 0,25564957 0,25648949 ! response to protein stimulus GO:0051789 158 96 0,000 0,25564957 0,25638419 ! regulation of T cell activation GO:0050863 175 96 0,000 0,25564957 0,25627899 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,25793839 0,25846739 ! transcription initiation GO:0006352 171 97 0,000 0,25793839 0,25836141 ! regulation of protein localization GO:0032880 188 97 0,000 0,25793839 0,25825553 ! mRNA transport GO:0051028 185 100 0,000 0,2647631 0,26498003 ! positive regulation of immune response GO:0050778 175 100 0,000 0,2647631 0,26487152 ! hormone metabolic process GO:0042445 171 100 0,000 0,2647631 0,2647631