pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6789-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 2,093E-09 4,813E-06 ! interphase of mitotic cell cycle GO:0051329 156 86 8,000 3,869E-08 4,45E-05 ! interphase GO:0051325 159 88 8,000 4,74E-08 3,634E-05 ! positive regulation of cell cycle GO:0045787 77 45 6,000 8,141E-08 4,681E-05 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 4,365E-07 2,008E-04 ! negative regulation of kinase activity GO:0033673 100 58 6,000 4,93E-07 1,89E-04 ! negative regulation of transferase activity GO:0051348 105 61 6,000 7,007E-07 2,302E-04 ! regulation of B cell proliferation GO:0030888 15 10 3,000 9,173E-07 2,637E-04 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 1,093E-06 2,793E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 1,371E-06 3,154E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 1,703E-06 3,56E-04 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 3,887E-06 7,45E-04 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 8,397E-06 1,486E-03 ! lung development GO:0030324 94 59 5,000 9,209E-06 1,513E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 9,936E-06 1,524E-03 ! prostate gland development GO:0030850 9 6 2,000 1,098E-05 1,578E-03 ! respiratory tube development GO:0030323 99 62 5,000 1,231E-05 1,666E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 1,269E-05 1,622E-03 ! negative regulation of cell size GO:0045792 108 64 5,000 1,481E-05 1,793E-03 ! respiratory system development GO:0060541 100 64 5,000 1,481E-05 1,703E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,909E-05 2,091E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 1,984E-05 2,074E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 2,736E-05 2,736E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 3,036E-05 2,909E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 2,000 3,036E-05 2,793E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 3,036E-05 2,686E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 3,036E-05 2,586E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 3,036E-05 2,494E-03 ! regulation of embryonic development GO:0045995 16 8 2,000 3,036E-05 2,408E-03 ! regulation of mast cell proliferation GO:0070666 64 44 4,000 3,066E-05 2,351E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 3,426E-05 2,542E-03 ! response to UV GO:0009411 75 46 4,000 3,819E-05 2,745E-03 ! negative regulation of immune system process GO:0002683 73 47 4,000 4,245E-05 2,959E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 4,000 4,245E-05 2,872E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of developmental growth GO:0048638 13 9 2,000 4,526E-05 2,974E-03 ! ear development GO:0043583 72 50 4,000 5,747E-05 3,672E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 6,33E-05 3,935E-03 ! protein sumoylation GO:0016925 12 10 2,000 6,427E-05 3,89E-03 ! regulation of B cell activation GO:0050864 42 28 3,000 7,963E-05 4,696E-03 ! cell cycle arrest GO:0007050 150 86 5,000 7,999E-05 4,599E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 8,783E-05 4,927E-03 ! actin cytoskeleton reorganization GO:0031532 21 11 2,000 8,783E-05 4,81E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 8,783E-05 4,698E-03 GO:0042130|negative regulation of T cell proliferation, ! positive regulation of cell motion GO:0051272 99 56 4,000 9,957E-05 5,205E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 1,084E-04 5,541E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 1,164E-04 5,82E-03 ! auditory receptor cell differentiation GO:0042491 25 12 2,000 1,164E-04 5,696E-03 ! regulation of homeostatic process GO:0032844 105 60 4,000 1,386E-04 6,642E-03 ! angiogenesis GO:0001525 149 95 5,000 1,391E-04 6,529E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,504E-04 6,918E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 1,504E-04 6,783E-03 ! androgen receptor signaling pathway GO:0030521 54 33 3,000 1,541E-04 6,816E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 1,621E-04 7,034E-03 ! cell cycle checkpoint GO:0000075 108 64 4,000 1,885E-04 8,027E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 2,364E-04 9,885E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 2,364E-04 9,708E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 2,364E-04 9,538E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 2,364E-04 9,373E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of T cell proliferation GO:0042129 58 38 3,000 2,692E-04 0,01049335 ! negative regulation of immune response GO:0050777 28 16 2,000 2,892E-04 0,01108416 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 2,892E-04 0,01090245 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 2,98E-04 0,01105557 ! inner ear development GO:0048839 57 40 3,000 3,29E-04 0,0120116 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 2,000 3,49E-04 0,01254161 ! peptidyl-serine modification GO:0018209 27 17 2,000 3,49E-04 0,01234867 ! energy reserve metabolic process GO:0006112 59 41 3,000 3,622E-04 0,01262382 ! regulation of T cell differentiation GO:0045580 59 41 3,000 3,622E-04 0,01243541 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 3,726E-04 0,01260276 ! negative regulation of growth GO:0045926 123 75 4,000 3,966E-04 0,01321937 ! cellular component disassembly GO:0022411 64 42 3,000 3,978E-04 0,01307118 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 4,162E-04 0,01348391 ! negative regulation of neuron differentiation GO:0045665 24 18 2,000 4,162E-04 0,01329663 ! negative regulation of T cell activation GO:0050868 25 18 2,000 4,162E-04 0,01311448 ! regulation of DNA binding GO:0051101 119 77 4,000 4,48E-04 0,01392474 ! gland development GO:0048732 148 77 4,000 4,48E-04 0,01373908 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 4,913E-04 0,01486807 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 4,913E-04 0,01467497 ! apoptotic nuclear changes GO:0030262 24 19 2,000 4,913E-04 0,01448683 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 4,913E-04 0,01430346 ! regulation of cell cycle process GO:0010564 122 81 4,000 5,658E-04 0,01626647 ! positive regulation of B cell activation GO:0050871 31 20 2,000 5,745E-04 0,01631269 ! regulation of cell adhesion GO:0030155 159 83 4,000 6,327E-04 0,01774711 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 6,655E-04 0,01844054 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 6,662E-04 0,01824066 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 6,662E-04 0,01802606 ! regulation of DNA recombination GO:0000018 40 21 2,000 6,662E-04 0,01781646 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 6,662E-04 0,01761167 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 6,662E-04 0,01741154 ! negative regulation of bone resorption GO:0045779 10 5 1,000 6,721E-04 0,01736962 ! positive regulation of glycolysis GO:0045821 11 5 1,000 6,721E-04 0,01717663 ! anagen GO:0042640 6 5 1,000 6,721E-04 0,01698787 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 6,721E-04 0,01680322 ! microvillus organization GO:0032528 7 5 1,000 6,721E-04 0,01662254 GO:0030033|microvillus assembly, ! response to food GO:0032094 5 5 1,000 6,721E-04 0,01644571 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 6,721E-04 0,01627259 ! positive regulation of neuroblast proliferation GO:0002052 8 5 1,000 6,721E-04 0,01610309 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 6,721E-04 0,01593708 ! early endosome to late endosome transport GO:0045022 11 5 1,000 6,721E-04 0,01577445 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 1,000 6,721E-04 0,01561511 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 6,721E-04 0,01545896 GO:0045686|negative regulation of glial cell differentiation, ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 6,721E-04 0,0153059 GO:0002707|negative regulation of lymphocyte mediated immunity, ! cranial nerve morphogenesis GO:0021602 6 5 1,000 6,721E-04 0,01515585 ! muscle cell proliferation GO:0033002 8 5 1,000 6,721E-04 0,0150087 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 6,721E-04 0,01486439 ! regulation of respiratory burst GO:0060263 8 5 1,000 6,721E-04 0,01472282 ! regulation of hair follicle development GO:0051797 9 5 1,000 6,721E-04 0,01458393 GO:0042634|regulation of hair cycle, ! apical protein localization GO:0045176 6 5 1,000 6,721E-04 0,01444763 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 1,000 6,721E-04 0,01431385 ! glial cell migration GO:0008347 10 5 1,000 6,721E-04 0,01418253 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 6,721E-04 0,0140536 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 6,721E-04 0,01392699 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! regulation of DNA metabolic process GO:0051052 135 85 4,000 7,054E-04 0,01448632 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 7,054E-04 0,01435812 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 7,667E-04 0,01546847 ! molting cycle process GO:0022404 40 22 2,000 7,667E-04 0,01533396 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! positive regulation of growth GO:0045927 67 50 3,000 7,776E-04 0,01541786 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 8,764E-04 0,01722775 ! protein modification by small protein conjugation GO:0032446 140 90 4,000 9,144E-04 0,01782354 ! skeletal system morphogenesis GO:0048705 78 53 3,000 9,699E-04 0,0187459 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 9,955E-04 0,01908054 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 9,955E-04 0,01892284 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,003E-03 0,01890346 ! mRNA stabilization GO:0048255 15 6 1,000 1,003E-03 0,01874977 GO:0043489|RNA stabilization, ! thymic T cell selection GO:0045061 12 6 1,000 1,003E-03 0,01859857 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 1,003E-03 0,01844978 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,003E-03 0,01830335 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,003E-03 0,01815923 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 1,003E-03 0,01801736 ! male sex determination GO:0030238 9 6 1,000 1,003E-03 0,01787769 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 1,003E-03 0,01774017 ! hair follicle maturation GO:0048820 7 6 1,000 1,003E-03 0,01760475 ! salivary gland morphogenesis GO:0007435 11 6 1,000 1,003E-03 0,01747138 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,003E-03 0,01734002 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 1,003E-03 0,01721061 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 1,06E-03 0,01806114 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,124E-03 0,01901589 ! positive regulation of MAPKKK cascade GO:0043410 36 25 2,000 1,124E-03 0,01887709 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,124E-03 0,0187403 ! regulation of binding GO:0051098 151 95 4,000 1,166E-03 0,01929952 ! protein modification by small protein conjugation or removal GO:0070647 148 96 4,000 1,222E-03 0,02008147 ! response to light stimulus GO:0009416 153 96 4,000 1,222E-03 0,01993905 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,263E-03 0,02046351 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,263E-03 0,02032041 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 1,361E-03 0,0217387 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,396E-03 0,02214585 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,396E-03 0,02199416 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,396E-03 0,02184454 ! positive regulation of isotype switching GO:0045830 15 7 1,000 1,396E-03 0,02169694 GO:0045911|positive regulation of DNA recombination, ! asymmetric protein localization GO:0008105 8 7 1,000 1,396E-03 0,02155133 ! protein heterooligomerization GO:0051291 10 7 1,000 1,396E-03 0,02140765 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,396E-03 0,02126588 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 1,396E-03 0,02112597 GO:0002714|positive regulation of B cell mediated immunity, ! neuroblast proliferation GO:0007405 13 7 1,000 1,396E-03 0,02098789 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,396E-03 0,02085161 ! positive regulation of epidermis development GO:0045684 11 7 1,000 1,396E-03 0,02071708 ! regulation of synaptogenesis GO:0051963 10 7 1,000 1,396E-03 0,02058428 ! dopamine biosynthetic process GO:0042416 15 7 1,000 1,396E-03 0,02045317 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 1,396E-03 0,02032372 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 1,396E-03 0,0201959 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 1,396E-03 0,02006967 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,413E-03 0,02018197 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 1,413E-03 0,02005739 GO:0043433|negative regulation of transcription factor activity, ! cell junction assembly GO:0034329 56 28 2,000 1,573E-03 0,02219163 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,573E-03 0,02205631 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,573E-03 0,02192264 ! cell-matrix adhesion GO:0007160 114 61 3,000 1,642E-03 0,02275459 ! regulation of transcription factor activity GO:0051090 97 63 3,000 1,851E-03 0,02548975 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 1,851E-03 0,02533802 ! induction of positive chemotaxis GO:0050930 14 8 1,000 1,851E-03 0,02519677 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,851E-03 0,02504856 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,851E-03 0,02490207 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,851E-03 0,02475729 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,851E-03 0,02461419 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,851E-03 0,02447273 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,851E-03 0,02433288 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,851E-03 0,02419463 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,851E-03 0,02405793 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,851E-03 0,02392278 ! spindle organization GO:0007051 37 30 2,000 1,926E-03 0,02474274 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,926E-03 0,02460528 ! regulation of MAPKKK cascade GO:0043408 101 65 3,000 2,077E-03 0,02639192 ! DNA damage checkpoint GO:0000077 53 31 2,000 2,119E-03 0,02677969 ! cell-substrate adhesion GO:0031589 121 66 3,000 2,197E-03 0,02761083 ! axon guidance GO:0007411 99 66 3,000 2,197E-03 0,02746077 ! meiosis I GO:0007127 52 32 2,000 2,324E-03 0,02889552 ! regulation of protein stability GO:0031647 48 32 2,000 2,324E-03 0,02874017 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,367E-03 0,02911848 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 2,367E-03 0,02896359 ! regulation of glycolysis GO:0006110 15 9 1,000 2,367E-03 0,02881034 ! protein complex disassembly GO:0043241 17 9 1,000 2,367E-03 0,02865871 GO:0043624|cellular protein complex disassembly, ! lung alveolus development GO:0048286 17 9 1,000 2,367E-03 0,02850866 ! T cell selection GO:0045058 18 9 1,000 2,367E-03 0,02836018 ! telomere maintenance via telomerase GO:0007004 12 9 1,000 2,367E-03 0,02821324 GO:0010833|telomere maintenance via telomere lengthening, ! receptor clustering GO:0043113 15 9 1,000 2,367E-03 0,02806781 ! epithelial cell development GO:0002064 10 9 1,000 2,367E-03 0,02792387 ! motor axon guidance GO:0008045 14 9 1,000 2,367E-03 0,0277814 ! postreplication repair GO:0006301 11 9 1,000 2,367E-03 0,02764038 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 2,367E-03 0,02750078 GO:0002820|negative regulation of adaptive immune response, ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,367E-03 0,02736259 ! regulation of synapse organization GO:0050807 12 9 1,000 2,367E-03 0,02722577 ! localization within membrane GO:0051668 15 9 1,000 2,367E-03 0,02709032 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 2,541E-03 0,02893464 ! ear morphogenesis GO:0042471 42 33 2,000 2,541E-03 0,0287921 ! cell junction organization GO:0034330 63 33 2,000 2,541E-03 0,02865097 ! carbohydrate homeostasis GO:0033500 39 33 2,000 2,541E-03 0,02851121 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 2,000 2,541E-03 0,0283728 ! negative regulation of DNA binding GO:0043392 54 33 2,000 2,541E-03 0,02823574 ! positive regulation of cell development GO:0010720 54 33 2,000 2,541E-03 0,02809999 ! regulation of catabolic process GO:0009894 106 70 3,000 2,724E-03 0,02998192 ! DNA integrity checkpoint GO:0031570 57 34 2,000 2,77E-03 0,03034191 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 2,77E-03 0,03019811 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 2,869E-03 0,0311233 ! regulation of phosphatase activity GO:0010921 21 10 1,000 2,943E-03 0,03178164 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,943E-03 0,03163313 ! hippocampus development GO:0021766 19 10 1,000 2,943E-03 0,031486 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,943E-03 0,03134023 ! blood vessel remodeling GO:0001974 21 10 1,000 2,943E-03 0,03119581 ! positive regulation of heart contraction GO:0045823 14 10 1,000 2,943E-03 0,03105271 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,943E-03 0,03091091 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,943E-03 0,03077041 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,943E-03 0,03063118 ! glucan biosynthetic process GO:0009250 13 10 1,000 2,943E-03 0,0304932 GO:0005978|glycogen biosynthetic process, ! regulation of bone resorption GO:0045124 24 10 1,000 2,943E-03 0,03035646 ! RNA-dependent DNA replication GO:0006278 13 10 1,000 2,943E-03 0,03022094 ! regulation of B cell differentiation GO:0045577 16 10 1,000 2,943E-03 0,03008662 ! cranial nerve development GO:0021545 12 10 1,000 2,943E-03 0,0299535 ! salivary gland development GO:0007431 22 10 1,000 2,943E-03 0,02982154 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,943E-03 0,02969075 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,943E-03 0,02956109 GO:0043470|regulation of carbohydrate catabolic process, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 2,943E-03 0,02943256 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,943E-03 0,02930515 ! regulation of synapse structure and activity GO:0050803 13 10 1,000 2,943E-03 0,02917884 ! negative regulation of immune effector process GO:0002698 16 10 1,000 2,943E-03 0,0290536 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 3,012E-03 0,02960335 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to hypoxia GO:0001666 132 72 3,000 3,018E-03 0,02953998 ! mitochondrion organization GO:0007005 104 73 3,000 3,173E-03 0,03092243 ! negative regulation of binding GO:0051100 58 36 2,000 3,266E-03 0,03169381 ! tissue remodeling GO:0048771 62 36 2,000 3,266E-03 0,03156064 ! response to oxygen levels GO:0070482 137 74 3,000 3,333E-03 0,0320742 ! protein import into nucleus GO:0006606 118 74 3,000 3,333E-03 0,03194056 ! regulation of ligase activity GO:0051340 114 75 3,000 3,498E-03 0,0333868 ! nuclear import GO:0051170 121 75 3,000 3,498E-03 0,03324883 ! ER-associated protein catabolic process GO:0030433 14 11 1,000 3,578E-03 0,03386391 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! virus-host interaction GO:0019048 17 11 1,000 3,578E-03 0,03372512 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 3,578E-03 0,03358747 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 3,578E-03 0,03345093 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 3,578E-03 0,03331551 ! T cell proliferation GO:0042098 20 11 1,000 3,578E-03 0,03318117 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 3,578E-03 0,03304791 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 3,578E-03 0,03291572 ! focal adhesion formation GO:0048041 24 11 1,000 3,578E-03 0,03278458 ! mitotic spindle organization GO:0007052 15 11 1,000 3,578E-03 0,03265448 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 3,578E-03 0,03252541 ! T cell homeostasis GO:0043029 20 11 1,000 3,578E-03 0,03239736 ! regulation of isotype switching GO:0045191 19 11 1,000 3,578E-03 0,03227031 ! regulation of leukocyte migration GO:0002685 24 11 1,000 3,578E-03 0,03214426 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 3,669E-03 0,03283792 ! pigmentation GO:0043473 74 38 2,000 3,812E-03 0,03398596 ! cell growth GO:0016049 61 39 2,000 4,105E-03 0,03645543 ! cartilage condensation GO:0001502 18 12 1,000 4,27E-03 0,03777375 ! positive regulation of cell growth GO:0030307 16 12 1,000 4,27E-03 0,03762902 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 4,27E-03 0,0374854 ! cell-cell junction assembly GO:0007043 18 12 1,000 4,27E-03 0,03734287 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 4,27E-03 0,03720142 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 4,27E-03 0,03706103 ! autonomic nervous system development GO:0048483 23 12 1,000 4,27E-03 0,03692171 ! gland morphogenesis GO:0022612 23 12 1,000 4,27E-03 0,03678342 ! peptidyl-lysine modification GO:0018205 18 12 1,000 4,27E-03 0,03664617 ! regulation of epidermis development GO:0045682 17 12 1,000 4,27E-03 0,03650994 ! regulation of mRNA stability GO:0043488 27 12 1,000 4,27E-03 0,03637472 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 4,27E-03 0,03624049 ! protein localization in nucleus GO:0034504 133 80 3,000 4,41E-03 0,03728752 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 4,411E-03 0,03716543 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 4,411E-03 0,03702979 ! epithelial cell differentiation GO:0030855 55 41 2,000 4,731E-03 0,03956872 ! glucose transport GO:0015758 52 41 2,000 4,731E-03 0,03942536 ! positive regulation of DNA binding GO:0043388 57 41 2,000 4,731E-03 0,03928303 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 5,019E-03 0,041525 ! endocrine pancreas development GO:0031018 19 13 1,000 5,019E-03 0,04137616 ! exocrine system development GO:0035272 27 13 1,000 5,019E-03 0,04122839 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 5,019E-03 0,04108167 ! cellular pigmentation GO:0033059 24 13 1,000 5,019E-03 0,04093599 ! regulation of RNA stability GO:0043487 28 13 1,000 5,019E-03 0,04079134 ! lymphocyte homeostasis GO:0002260 24 13 1,000 5,019E-03 0,04064771 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 2,000 5,064E-03 0,04087034 ! hexose transport GO:0008645 54 42 2,000 5,064E-03 0,04072744 GO:0015749|monosaccharide transport, ! regulation of cell shape GO:0008360 78 42 2,000 5,064E-03 0,04058553 ! positive regulation of binding GO:0051099 59 43 2,000 5,412E-03 0,04321692 ! activation of caspase activity GO:0006919 65 43 2,000 5,412E-03 0,04306738 ! glycolysis GO:0006096 53 44 2,000 5,773E-03 0,04578285 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 5,824E-03 0,04603097 ! regulation of S phase GO:0033261 18 14 1,000 5,824E-03 0,04587333 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,824E-03 0,04571676 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 5,824E-03 0,04556126 ! limbic system development GO:0021761 25 14 1,000 5,824E-03 0,04540682 ! epidermis morphogenesis GO:0048730 29 14 1,000 5,824E-03 0,04525342 ! cellular response to starvation GO:0009267 21 14 1,000 5,824E-03 0,04510105 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 5,824E-03 0,0449497 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 5,824E-03 0,04479937 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 5,824E-03 0,04465004 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 5,824E-03 0,0445017 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,824E-03 0,04435434 ! reproductive developmental process GO:0003006 127 89 3,000 6,429E-03 0,04880445 ! regulation of T cell activation GO:0050863 128 89 3,000 6,429E-03 0,04864391 ! positive regulation of cell size GO:0045793 20 15 1,000 6,684E-03 0,05040047 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 6,684E-03 0,05023576 ! lipid phosphorylation GO:0046834 23 15 1,000 6,684E-03 0,05007213 ! positive regulation of proteolysis GO:0045862 19 15 1,000 6,684E-03 0,04990956 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 6,684E-03 0,04974804 ! neuron recognition GO:0008038 22 15 1,000 6,684E-03 0,04958756 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 6,684E-03 0,04942812 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 6,684E-03 0,04926969 ! dopamine metabolic process GO:0042417 30 15 1,000 6,684E-03 0,04911228 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 6,684E-03 0,04895587 ! defense response to virus GO:0051607 27 15 1,000 6,684E-03 0,04880046 ! positive regulation of caspase activity GO:0043280 72 48 2,000 7,36E-03 0,05356654 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 2,000 7,36E-03 0,05339756 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 7,597E-03 0,05494704 ! protein amino acid acetylation GO:0006473 28 16 1,000 7,597E-03 0,05477479 ! regulation of dephosphorylation GO:0035303 33 16 1,000 7,597E-03 0,05460362 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 7,597E-03 0,05443351 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 7,597E-03 0,05426446 ! G1 phase GO:0051318 27 16 1,000 7,597E-03 0,05409646 ! neutrophil chemotaxis GO:0030593 21 16 1,000 7,597E-03 0,0539295 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 7,597E-03 0,05376356 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 1,000 7,597E-03 0,05359864 ! nerve development GO:0021675 18 16 1,000 7,597E-03 0,05343473 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 7,597E-03 0,05327182 ! regulation of angiogenesis GO:0045765 94 49 2,000 7,793E-03 0,0544771 ! positive regulation of cell killing GO:0031343 24 17 1,000 8,563E-03 0,05968451 ! signal complex assembly GO:0007172 29 17 1,000 8,563E-03 0,0595042 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 8,563E-03 0,05932497 ! inactivation of MAPK activity GO:0000188 27 17 1,000 8,563E-03 0,05914682 ! cell-substrate junction assembly GO:0007044 39 17 1,000 8,563E-03 0,05896973 ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 8,563E-03 0,0587937 ! actin filament bundle formation GO:0051017 26 17 1,000 8,563E-03 0,05861872 ! neuromuscular junction development GO:0007528 23 17 1,000 8,563E-03 0,05844478 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 8,563E-03 0,05827186 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 8,563E-03 0,05809997 GO:0002712|regulation of B cell mediated immunity, ! cell-cell junction organization GO:0045216 25 17 1,000 8,563E-03 0,05792909 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 8,563E-03 0,05775921 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 8,563E-03 0,05759032 ! positive regulation of synaptic transmission GO:0050806 24 17 1,000 8,563E-03 0,05742242 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 8,673E-03 0,05798786 ! regulation of protein catabolic process GO:0042176 77 51 2,000 8,703E-03 0,05801988 ! protein import GO:0017038 156 99 3,000 9,304E-03 0,06184919 ! positive regulation of DNA replication GO:0045740 29 18 1,000 9,582E-03 0,06351068 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 9,582E-03 0,06332818 ! pancreas development GO:0031016 26 18 1,000 9,582E-03 0,06314672 ! response to retinoic acid GO:0032526 25 18 1,000 9,582E-03 0,0629663 ! central nervous system neuron development GO:0021954 30 18 1,000 9,582E-03 0,06278691 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 9,582E-03 0,06260854 ! somitogenesis GO:0001756 24 18 1,000 9,582E-03 0,06243118 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 9,582E-03 0,06225482 ! cellular response to nutrient levels GO:0031669 27 18 1,000 9,582E-03 0,06207945 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 1,000 9,582E-03 0,06190507 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 9,582E-03 0,06173167 ! protein localization in organelle GO:0033365 161 100 3,000 9,631E-03 0,06187417 ! regulation of bone remodeling GO:0046850 90 53 2,000 9,673E-03 0,06197318 ! regulation of mitosis GO:0007088 84 54 2,000 0,01018099 0,06504524 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 2,000 0,01018099 0,06486506 ! DNA catabolic process GO:0006308 67 54 2,000 0,01018099 0,06468587 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01018099 0,06450768 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,0106513 0,06730219 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,0106513 0,0671178 ! positive regulation of ossification GO:0045778 30 19 1,000 0,0106513 0,06693442 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 0,0106513 0,06675204 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,0106513 0,06657065 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 32 19 1,000 0,0106513 0,06639024 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,0106513 0,06621081 ! response to vitamin A GO:0033189 26 19 1,000 0,0106513 0,06603234 ! response to starvation GO:0042594 30 19 1,000 0,0106513 0,06585483 ! sex determination GO:0007530 29 19 1,000 0,0106513 0,06567828 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,0106513 0,06550267 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 0,0106513 0,065328 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 0,0106513 0,06515425 ! positive regulation of neurological system process GO:0031646 28 19 1,000 0,0106513 0,06498143 ! protein stabilization GO:0050821 26 19 1,000 0,0106513 0,06480952 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 0,01124235 0,06822536 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 0,01124235 0,06804582 ! response to vitamin GO:0033273 29 20 1,000 0,01177095 0,07105823 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 0,01177095 0,07087221 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,01177095 0,07068717 ! pallium development GO:0021543 38 20 1,000 0,01177095 0,07050308 ! positive regulation of locomotion GO:0040017 35 20 1,000 0,01177095 0,07031996 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 1,000 0,01177095 0,07013778 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 0,01177095 0,06995655 ! carbohydrate transport GO:0008643 74 57 2,000 0,01179608 0,0699252 ! developmental maturation GO:0021700 75 57 2,000 0,01179608 0,06974545 ! viral reproductive process GO:0022415 87 58 2,000 0,01236526 0,07292334 ! regulation of cell killing GO:0031341 34 21 1,000 0,01293987 0,0761169 ! positive regulation of bone remodeling GO:0046852 33 21 1,000 0,01293987 0,07592272 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01293987 0,07572954 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01293987 0,07553733 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01293987 0,07534609 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01293987 0,07515583 ! immunoglobulin production GO:0002377 33 21 1,000 0,01293987 0,07496652 GO:0002440|production of molecular mediator of immune response, ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 0,01293987 0,07477816 ! activation of MAPK activity GO:0000187 84 59 2,000 0,01294997 0,07464895 ! actin filament organization GO:0007015 95 59 2,000 0,01294997 0,07446233 ! myeloid cell differentiation GO:0030099 85 59 2,000 0,01294997 0,07427664 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01415719 0,08099885 ! viral genome replication GO:0019079 29 22 1,000 0,01415719 0,08079786 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01415719 0,08059786 ! macromolecular complex disassembly GO:0032984 38 22 1,000 0,01415719 0,08039886 ! vasculogenesis GO:0001570 33 22 1,000 0,01415719 0,08020083 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01415719 0,08000378 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 0,01415719 0,07980769 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of behavior GO:0050795 38 22 1,000 0,01415719 0,07961256 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01415719 0,07941838 ! protein tetramerization GO:0051262 39 22 1,000 0,01415719 0,07922515 ! regulation of cellular response to stress GO:0080135 85 61 2,000 0,01416619 0,07908311 ! meiosis GO:0007126 96 61 2,000 0,01416619 0,07889162 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 2,000 0,01416619 0,07870106 ! homeostasis of number of cells GO:0048872 84 61 2,000 0,01416619 0,07851142 ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01416619 0,07832269 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 0,01416619 0,07813487 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 0,01479781 0,08142335 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01479781 0,08122902 ! myelination GO:0042552 35 23 1,000 0,01542203 0,08445398 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01542203 0,08425337 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01542203 0,08405372 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01542203 0,08385501 ! interaction with host GO:0051701 37 23 1,000 0,01542203 0,08365724 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01542203 0,0834604 ! telomere organization GO:0032200 32 23 1,000 0,01542203 0,08326448 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01542203 0,08306948 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,01544516 0,0829997 ! viral reproduction GO:0016032 92 63 2,000 0,01544516 0,08280622 ! hexose catabolic process GO:0019320 82 64 2,000 0,01610829 0,0861606 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01673353 0,08929727 ! receptor metabolic process GO:0043112 37 24 1,000 0,01673353 0,08909057 ! negative regulation of cell development GO:0010721 56 24 1,000 0,01673353 0,08888482 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,01673353 0,08868001 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,01673353 0,08847615 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01673353 0,08827322 ! glutathione metabolic process GO:0006749 29 24 1,000 0,01673353 0,08807122 ! neurotransmitter secretion GO:0007269 32 24 1,000 0,01673353 0,08787015 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,01673353 0,08766999 ! reproductive structure development GO:0048608 90 65 2,000 0,01678722 0,08775139 ! regulation of caspase activity GO:0043281 97 65 2,000 0,01678722 0,08755241 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 0,01678722 0,08735433 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01678722 0,08715714 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,01809085 0,09371385 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,01809085 0,09350325 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01809085 0,09329361 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01809085 0,09308489 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01809085 0,09287712 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01809085 0,09267026 GO:0032943|mononuclear cell proliferation, ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01819265 0,09298466 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01819265 0,09277849 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01949313 0,09919073 ! positive regulation of ligase activity GO:0051351 99 69 2,000 0,01966165 0,09982736 ! inner ear morphogenesis GO:0042472 35 27 1,000 0,02093957 0,1060815 ! catechol metabolic process GO:0009712 43 27 1,000 0,02093957 0,10584836 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,02093957 0,10561623 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02093957 0,10538512 ! monosaccharide catabolic process GO:0046365 91 71 2,000 0,02119435 0,10643452 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,02198462 0,11016258 ! phenol metabolic process GO:0018958 44 28 1,000 0,02242932 0,11214662 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02242932 0,11190335 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,02242932 0,11166114 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,02242932 0,11141997 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,02242932 0,11117984 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02242932 0,11094074 GO:0008366|axon ensheathment, ! placenta development GO:0001890 37 28 1,000 0,02242932 0,11070267 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,023613 0,11629529 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,0239616 0,11776 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,0239616 0,11750892 ! telencephalon development GO:0021537 52 29 1,000 0,0239616 0,1172589 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,0255356 0,12469613 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,0255356 0,12443194 ! hindbrain development GO:0030902 45 30 1,000 0,0255356 0,12416887 ! response to heat GO:0009408 41 30 1,000 0,0255356 0,12390691 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,0255356 0,12364606 ! protein ubiquitination GO:0016567 125 77 2,000 0,02617513 0,12647648 ! mammary gland development GO:0030879 57 31 1,000 0,02715053 0,13091451 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,02715053 0,13064063 ! segmentation GO:0035282 41 31 1,000 0,02715053 0,13036789 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02715053 0,13009629 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02715053 0,12982582 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,02715053 0,12955647 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,02715053 0,12928824 ! regulation of muscle development GO:0048634 48 32 1,000 0,02880562 0,1368862 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02880562 0,13660396 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,02880562 0,13632289 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02880562 0,13604296 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02880562 0,13576419 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,02880562 0,13548655 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02880562 0,13521005 ! alcohol catabolic process GO:0046164 104 80 2,000 0,02888046 0,13528523 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,02888046 0,13501026 GO:0010498|proteasomal protein catabolic process, ! forebrain development GO:0030900 131 80 2,000 0,02888046 0,1347364 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,02981396 0,13880994 GO:0002696|positive regulation of leukocyte activation, ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,0305001 0,14171762 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,0305001 0,1414319 ! sister chromatid segregation GO:0000819 46 33 1,000 0,0305001 0,14114733 ! regulation of proteolysis GO:0030162 50 33 1,000 0,0305001 0,1408639 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,0305001 0,14058161 ! cytokinesis GO:0000910 52 33 1,000 0,0305001 0,14030044 ! ossification GO:0001503 134 82 2,000 0,03076329 0,14122866 GO:0060348|bone development, ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,03223321 0,14768202 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 0,03223321 0,14738842 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,03223321 0,14709598 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,03223321 0,1468047 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,03223321 0,14651457 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,03270928 0,14838531 ! Golgi vesicle transport GO:0048193 138 85 2,000 0,03370588 0,15260538 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,03370588 0,15230557 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,0340042 0,15335227 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,0340042 0,15305217 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,0340042 0,15275324 ! maintenance of protein location GO:0045185 65 35 1,000 0,0340042 0,15245547 ! glycogen metabolic process GO:0005977 48 35 1,000 0,0340042 0,15215887 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,0357461 0,15964276 GO:0060538|skeletal muscle organ development, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03581234 0,15962864 GO:0090047|positive regulation of transcription regulator activity, ! glucan metabolic process GO:0044042 49 36 1,000 0,03581234 0,15931988 GO:0006073|cellular glucan metabolic process, ! regulation of neurogenesis GO:0050767 153 89 2,000 0,0378487 0,16805406 ! gliogenesis GO:0042063 71 38 1,000 0,03953715 0,17521279 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,03953715 0,17487584 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03953715 0,17454018 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,03953715 0,17420582 ! response to virus GO:0009615 122 91 2,000 0,0400133 0,17596671 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04079355 0,17905568 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04079355 0,17871462 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04079355 0,17837486 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04079355 0,17803639 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04079355 0,1776992 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04079355 0,17736328 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04079355 0,17702863 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04079355 0,17669525 ! sleep GO:0030431 11 5 0,000 0,04079355 0,17636311 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04079355 0,17603222 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04079355 0,17570258 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04079355 0,17537416 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04079355 0,17504697 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04079355 0,174721 ! tongue development GO:0043586 6 5 0,000 0,04079355 0,17439624 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04079355 0,17407268 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04079355 0,17375033 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04079355 0,17342916 ! cobalt ion transport GO:0006824 9 5 0,000 0,04079355 0,17310918 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04079355 0,17279038 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04079355 0,17247275 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04079355 0,17215629 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04079355 0,17184098 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04079355 0,17152683 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04079355 0,17121382 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04079355 0,17090196 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04079355 0,17059123 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04079355 0,17028163 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04079355 0,16997314 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04079355 0,16966578 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04079355 0,16935952 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,04079355 0,16905437 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04079355 0,16875032 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04079355 0,16844735 ! malate metabolic process GO:0006108 7 5 0,000 0,04079355 0,16814548 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04079355 0,16784468 ! behavioral response to pain GO:0048266 7 5 0,000 0,04079355 0,16754496 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04079355 0,1672463 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04079355 0,16694871 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04079355 0,16665218 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04079355 0,16635669 ! mating behavior GO:0007617 6 5 0,000 0,04079355 0,16606226 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04079355 0,16576886 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04079355 0,1654765 ! rhythmic behavior GO:0007622 12 5 0,000 0,04079355 0,16518517 ! copulation GO:0007620 7 5 0,000 0,04079355 0,16489486 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04079355 0,16460557 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04079355 0,1643173 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04079355 0,16403003 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04079355 0,16374376 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04079355 0,16345849 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04079355 0,16317422 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04079355 0,16289093 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04079355 0,16260862 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04079355 0,16232729 ! response to protozoan GO:0001562 9 5 0,000 0,04079355 0,16204694 ! lymph vessel development GO:0001945 7 5 0,000 0,04079355 0,16176754 ! endochondral ossification GO:0001958 12 5 0,000 0,04079355 0,16148911 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04079355 0,16121164 ! parathyroid gland development GO:0060017 8 5 0,000 0,04079355 0,16093512 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04079355 0,16065955 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04079355 0,16038492 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04079355 0,16011122 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04079355 0,15983846 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04079355 0,15956663 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04079355 0,15929571 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04079355 0,15902572 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04079355 0,15875664 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04079355 0,15848847 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04079355 0,15822121 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04079355 0,15795484 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04079355 0,15768937 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04079355 0,15742479 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04079355 0,1571611 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04079355 0,15689829 ! ovulation GO:0030728 6 5 0,000 0,04079355 0,15663635 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04079355 0,15637529 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,04079355 0,1561151 ! response to pH GO:0009268 9 5 0,000 0,04079355 0,15585577 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04079355 0,15559731 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04079355 0,15533969 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04079355 0,15508293 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04079355 0,15482702 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04079355 0,15457195 ! polyol catabolic process GO:0046174 7 5 0,000 0,04079355 0,15431772 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04079355 0,15406433 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04079355 0,15381176 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04079355 0,15356003 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04079355 0,15330911 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04079355 0,15305901 ! urea metabolic process GO:0019627 6 5 0,000 0,04079355 0,15280973 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04079355 0,15256126 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04079355 0,1523136 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04079355 0,15206674 ! neutrophil activation GO:0042119 5 5 0,000 0,04079355 0,15182067 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04079355 0,1515754 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04079355 0,15133093 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04079355 0,15108724 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04079355 0,15084433 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04079355 0,15060221 ! forebrain neuron development GO:0021884 7 5 0,000 0,04079355 0,15036086 ! melanosome organization GO:0032438 7 5 0,000 0,04079355 0,15012028 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04079355 0,14988047 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04079355 0,14964143 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04079355 0,14940315 ! nucleoside transport GO:0015858 6 5 0,000 0,04079355 0,14916562 ! nucleoside salvage GO:0043174 7 5 0,000 0,04079355 0,14892885 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04079355 0,14869283 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04079355 0,14845756 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04079355 0,14822303 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04079355 0,14798924 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04079355 0,14775618 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04079355 0,14752386 ! depyrimidination GO:0045008 8 5 0,000 0,04079355 0,14729227 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04079355 0,1470614 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04079355 0,14683126 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04079355 0,14660184 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04079355 0,14637313 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04079355 0,14614513 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,04079355 0,14591785 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04079355 0,14569127 ! monocyte differentiation GO:0030224 8 5 0,000 0,04079355 0,14546539 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04079355 0,14524021 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04079355 0,14501573 ! centrosome duplication GO:0051298 5 5 0,000 0,04079355 0,14479194 ! response to UV-C GO:0010225 6 5 0,000 0,04079355 0,14456884 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04079355 0,14434642 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04079355 0,14412469 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04079355 0,14390364 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04079355 0,14368327 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04079355 0,14346357 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04079355 0,14324454 ! melanosome transport GO:0032402 8 5 0,000 0,04079355 0,14302618 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04079355 0,14280849 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04079355 0,14259145 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04079355 0,14237508 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04079355 0,14215936 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04079355 0,14194429 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04079355 0,14172987 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04079355 0,1415161 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04079355 0,14130298 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04079355 0,14109049 ! neural tube patterning GO:0021532 6 5 0,000 0,04079355 0,14087864 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04079355 0,14066743 ! histone demethylation GO:0016577 9 5 0,000 0,04079355 0,14045685 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04079355 0,1402469 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04079355 0,14003758 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04079355 0,13982888 ! enteric nervous system development GO:0048484 8 5 0,000 0,04079355 0,1396208 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04079355 0,13941334 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04079355 0,13920649 ! transcription termination GO:0006353 8 5 0,000 0,04079355 0,13900026 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04079355 0,13879464 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04079355 0,13858962 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04079355 0,13838521 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04079355 0,13818141 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04079355 0,1379782 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,04079355 0,13777559 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04079355 0,13757357 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04079355 0,13737215 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04079355 0,13717131 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04079355 0,13697106 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04079355 0,13677139 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04079355 0,13657231 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04079355 0,1363738 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,04079355 0,13617587 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04079355 0,13597852 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04079355 0,13578173 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04079355 0,13558551 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04079355 0,13538986 ! neural plate development GO:0001840 6 5 0,000 0,04079355 0,13519478 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04079355 0,13500025 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04079355 0,13480629 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04079355 0,13461288 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,04079355 0,13442002 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04079355 0,13422772 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04079355 0,13403597 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04079355 0,13384476 ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04079355 0,1336541 ! spindle assembly GO:0051225 5 5 0,000 0,04079355 0,13346398 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04079355 0,1332744 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04079355 0,13308536 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04079355 0,13289685 ! organ regeneration GO:0031100 7 5 0,000 0,04079355 0,13270888 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04079355 0,13252143 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04079355 0,13233452 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04079355 0,13214813 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04079355 0,13196227 GO:0055081|anion homeostasis, ! positive regulation of immune response GO:0050778 121 92 2,000 0,04111872 0,13282733 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,04145239 0,13371738 ! chromatin remodeling GO:0006338 68 39 1,000 0,04145239 0,1335301 ! developmental growth GO:0048589 62 39 1,000 0,04145239 0,13334334 ! synapse organization GO:0050808 55 39 1,000 0,04145239 0,13315711 ! carbohydrate catabolic process GO:0016052 121 93 2,000 0,04223948 0,13549623 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,04340191 0,1390312 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,04340191 0,13883783 ! peptide metabolic process GO:0006518 56 40 1,000 0,04340191 0,138645 ! T cell differentiation GO:0030217 65 40 1,000 0,04340191 0,13845271 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,04340191 0,13826094 ! endosome transport GO:0016197 71 41 1,000 0,04538503 0,1443784 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,04538503 0,14417898 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,04538503 0,14398011 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,04740107 0,15016867 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,04740107 0,14996211 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,04740107 0,14975612 ! tRNA transcription GO:0009304 11 6 0,000 0,04875172 0,15381203 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04875172 0,15360132 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04875172 0,1533912 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04875172 0,15318165 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04875172 0,15297267 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04875172 0,15276426 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04875172 0,15255642 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04875172 0,15234914 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04875172 0,15214242 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04875172 0,15193627 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04875172 0,15173067 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04875172 0,15152563 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04875172 0,15132114 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04875172 0,15111721 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04875172 0,15091382 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04875172 0,15071098 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04875172 0,15050868 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04875172 0,15030693 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04875172 0,15010571 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04875172 0,14990504 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04875172 0,14970489 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,04875172 0,14950529 ! neuron adhesion GO:0007158 9 6 0,000 0,04875172 0,14930621 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04875172 0,14910767 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04875172 0,14890965 ! signal peptide processing GO:0006465 8 6 0,000 0,04875172 0,14871216 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04875172 0,14851519 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04875172 0,14831874 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04875172 0,14812281 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04875172 0,1479274 ! opsonization GO:0008228 8 6 0,000 0,04875172 0,1477325 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04875172 0,14753811 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04875172 0,14734424 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04875172 0,14715087 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04875172 0,14695802 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04875172 0,14676566 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04875172 0,14657381 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04875172 0,14638246 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04875172 0,14619161 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04875172 0,14600126 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04875172 0,1458114 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04875172 0,14562203 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04875172 0,14543316 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04875172 0,14524477 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04875172 0,14505688 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04875172 0,14486947 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04875172 0,14468254 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04875172 0,14449609 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04875172 0,14431012 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04875172 0,14412464 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04875172 0,14393962 ! protein lipoylation GO:0009249 10 6 0,000 0,04875172 0,14375508 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04875172 0,14357102 ! pigment granule organization GO:0048753 11 6 0,000 0,04875172 0,14338742 ! drug transport GO:0015893 6 6 0,000 0,04875172 0,1432043 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04875172 0,14302164 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04875172 0,14283945 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04875172 0,14265772 ! histidine metabolic process GO:0006547 6 6 0,000 0,04875172 0,14247645 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04875172 0,14229564 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04875172 0,14211529 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04875172 0,1419354 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04875172 0,14175596 ! adenohypophysis development GO:0021984 10 6 0,000 0,04875172 0,14157698 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04875172 0,14139844 ! hyperosmotic response GO:0006972 8 6 0,000 0,04875172 0,14122036 ! microtubule nucleation GO:0007020 10 6 0,000 0,04875172 0,14104272 ! ER overload response GO:0006983 7 6 0,000 0,04875172 0,14086554 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04875172 0,14068879 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04875172 0,14051249 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04875172 0,14033663 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04875172 0,14016121 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04875172 0,13998623 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04875172 0,13981168 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04875172 0,13963757 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04875172 0,13946389 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04875172 0,13929064 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04875172 0,13911782 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04875172 0,13894544 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04875172 0,13877347 ! neuron apoptosis GO:0051402 8 6 0,000 0,04875172 0,13860194 ! organic alcohol transport GO:0015850 9 6 0,000 0,04875172 0,13843082 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04875172 0,13826013 ! carnitine transport GO:0015879 8 6 0,000 0,04875172 0,13808986 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04875172 0,13792001 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04875172 0,13775057 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04875172 0,13758155 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04875172 0,13741295 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04875172 0,13724476 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04875172 0,13707698 ! parturition GO:0007567 12 6 0,000 0,04875172 0,1369096 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04875172 0,13674264 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04875172 0,13657609 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04875172 0,13640993 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04875172 0,13624419 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04875172 0,13607884 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04875172 0,1359139 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04875172 0,13574935 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04875172 0,13558521 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04875172 0,13542146 ! macrophage differentiation GO:0030225 10 6 0,000 0,04875172 0,1352581 ! astrocyte development GO:0014002 14 6 0,000 0,04875172 0,13509514 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04875172 0,13493257 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04875172 0,13477039 ! interaction with symbiont GO:0051702 8 6 0,000 0,04875172 0,1346086 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04875172 0,1344472 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04875172 0,13428619 ! eating behavior GO:0042755 6 6 0,000 0,04875172 0,13412556 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04875172 0,13396531 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04875172 0,13380545 ! response to copper ion GO:0046688 9 6 0,000 0,04875172 0,13364597 ! DNA topological change GO:0006265 8 6 0,000 0,04875172 0,13348686 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04875172 0,13332814 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04875172 0,13316979 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04875172 0,13301182 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04875172 0,13285423 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04875172 0,132697 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04875172 0,13254015 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04875172 0,13238367 ! gas homeostasis GO:0033483 11 6 0,000 0,04875172 0,13222755 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04875172 0,13207181 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04875172 0,13191643 ! Schwann cell development GO:0014044 14 6 0,000 0,04875172 0,13176142 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04875172 0,13160677 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04875172 0,13145248 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04875172 0,13129856 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04875172 0,13114499 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04875172 0,13099178 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04875172 0,13083893 ! histone ubiquitination GO:0016574 7 6 0,000 0,04875172 0,13068644 ! regulation of meiosis GO:0040020 10 6 0,000 0,04875172 0,1305343 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04875172 0,13038252 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04875172 0,13023109 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04875172 0,13008001 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04875172 0,12992928 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04875172 0,1297789 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04875172 0,12962886 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04875172 0,12947918 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04875172 0,12932983 ! receptor internalization GO:0031623 9 6 0,000 0,04875172 0,12918084 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04875172 0,12903218 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04875172 0,12888387 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04875172 0,1287359 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,04875172 0,12858826 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04875172 0,12844097 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04875172 0,12829401 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04875172 0,12814739 ! axonal fasciculation GO:0007413 9 6 0,000 0,04875172 0,1280011 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04875172 0,12785515 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04875172 0,12770953 ! midbrain development GO:0030901 6 6 0,000 0,04875172 0,12756424 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04875172 0,12741928 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04875172 0,12727465 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04875172 0,12713035 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04875172 0,12698637 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04875172 0,12684272 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04875172 0,1266994 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04875172 0,1265564 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04875172 0,12641372 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04875172 0,12627136 ! adult feeding behavior GO:0008343 6 6 0,000 0,04875172 0,12612932 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04875172 0,1259876 ! blastocyst growth GO:0001832 15 6 0,000 0,04875172 0,1258462 ! pigment granule transport GO:0051904 12 6 0,000 0,04875172 0,12570512 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04875172 0,12556435 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04875172 0,1254239 ! catecholamine transport GO:0051937 7 6 0,000 0,04875172 0,12528376 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04875172 0,12514394 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04875172 0,12500442 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04875172 0,12486522 ! protein prenylation GO:0018342 10 6 0,000 0,04875172 0,12472633 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04875172 0,12458774 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04875172 0,12444946 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04875172 0,12431149 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04875172 0,12417383 ! extracellular structure organization GO:0043062 156 99 2,000 0,04928266 0,12538729 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,04928266 0,12524874 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,04944934 0,12553364 ! leukocyte migration GO:0050900 60 43 1,000 0,04944934 0,12539524 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04944934 0,12525714 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,04944934 0,12511934 ! regulation of action potential GO:0001508 71 44 1,000 0,05152918 0,13023859 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,05152918 0,13009563 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,05152918 0,12995298 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,05363994 0,13512801 ! cell recognition GO:0008037 58 45 1,000 0,05363994 0,13498016 ! cell maturation GO:0048469 60 45 1,000 0,05363994 0,13483264 ! regulation of ossification GO:0030278 71 46 1,000 0,05578097 0,14006139 ! histone modification GO:0016570 68 46 1,000 0,05578097 0,13990865 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,05578097 0,13975625 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05664432 0,14176489 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05664432 0,1416108 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05664432 0,14145704 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05664432 0,14130362 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05664432 0,14115053 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05664432 0,14099777 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05664432 0,14084534 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05664432 0,14069324 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05664432 0,14054146 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05664432 0,14039002 ! reproductive behavior GO:0019098 12 7 0,000 0,05664432 0,1402389 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05664432 0,1400881 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05664432 0,13993763 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,05664432 0,13978748 ! oligopeptide transport GO:0006857 11 7 0,000 0,05664432 0,13963766 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05664432 0,13948815 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05664432 0,13933897 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05664432 0,1391901 ! RNA methylation GO:0001510 11 7 0,000 0,05664432 0,13904155 ! pericardium development GO:0060039 8 7 0,000 0,05664432 0,13889332 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05664432 0,13874541 ! fibril organization GO:0043206 13 7 0,000 0,05664432 0,1385978 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,05664432 0,13845052 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05664432 0,13830354 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05664432 0,13815688 ! lipoprotein transport GO:0042953 9 7 0,000 0,05664432 0,13801053 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05664432 0,13786448 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05664432 0,13771875 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05664432 0,13757332 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05664432 0,1374282 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05664432 0,13728339 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05664432 0,13713888 ! chemosensory behavior GO:0007635 9 7 0,000 0,05664432 0,13699468 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05664432 0,13685077 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05664432 0,13670717 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05664432 0,13656387 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05664432 0,13642088 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05664432 0,13627818 ! reflex GO:0060004 12 7 0,000 0,05664432 0,13613577 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05664432 0,13599367 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05664432 0,13585186 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05664432 0,13571035 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05664432 0,13556913 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05664432 0,13542821 ! spinal cord patterning GO:0021511 7 7 0,000 0,05664432 0,13528758 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05664432 0,13514724 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05664432 0,13500719 ! adrenal gland development GO:0030325 17 7 0,000 0,05664432 0,13486743 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05664432 0,13472796 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05664432 0,13458878 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05664432 0,13444988 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05664432 0,13431127 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05664432 0,13417295 ! endosome organization GO:0007032 10 7 0,000 0,05664432 0,13403491 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05664432 0,13389716 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05664432 0,13375969 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05664432 0,1336225 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05664432 0,13348559 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05664432 0,13334896 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05664432 0,13321261 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05664432 0,13307654 ! galactose metabolic process GO:0006012 10 7 0,000 0,05664432 0,13294075 ! vesicle fusion GO:0006906 15 7 0,000 0,05664432 0,13280524 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05664432 0,13267 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,05664432 0,13253503 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05664432 0,13240034 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05664432 0,13226592 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05664432 0,13213178 ! retinol metabolic process GO:0042572 9 7 0,000 0,05664432 0,13199791 ! behavioral fear response GO:0001662 13 7 0,000 0,05664432 0,13186431 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05664432 0,13173098 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05664432 0,13159792 ! rRNA modification GO:0000154 12 7 0,000 0,05664432 0,13146512 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05664432 0,1313326 ! response to UV-B GO:0010224 11 7 0,000 0,05664432 0,13120034 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,05664432 0,13106835 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05664432 0,13093662 ! intermediate filament organization GO:0045109 11 7 0,000 0,05664432 0,13080516 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05664432 0,13067396 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05664432 0,13054302 ! fibrinolysis GO:0042730 9 7 0,000 0,05664432 0,13041235 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05664432 0,13028194 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05664432 0,13015178 ! B cell lineage commitment GO:0002326 17 7 0,000 0,05664432 0,13002189 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05664432 0,12989226 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05664432 0,12976288 ! response to tropane GO:0014073 13 7 0,000 0,05664432 0,12963377 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05664432 0,12950491 ! melanosome localization GO:0032400 10 7 0,000 0,05664432 0,1293763 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05664432 0,12924795 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05664432 0,12911986 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05664432 0,12899202 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05664432 0,12886443 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05664432 0,12873709 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05664432 0,12861001 ! mast cell activation GO:0045576 9 7 0,000 0,05664432 0,12848317 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05664432 0,12835659 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05664432 0,12823025 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05664432 0,12810417 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05664432 0,12797833 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05664432 0,12785273 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05664432 0,12772739 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05664432 0,12760229 ! T cell lineage commitment GO:0002360 12 7 0,000 0,05664432 0,12747743 ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05664432 0,12735282 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05664432 0,12722845 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05664432 0,12710433 ! response to tumor cell GO:0002347 12 7 0,000 0,05664432 0,12698044 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05664432 0,1268568 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05664432 0,1267334 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05664432 0,12661024 ! diuresis GO:0030146 12 7 0,000 0,05664432 0,12648732 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05664432 0,12636463 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05664432 0,12624219 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05664432 0,12611998 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05664432 0,125998 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05664432 0,12587627 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05664432 0,12575476 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05664432 0,1256335 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05664432 0,12551246 ! lymph node development GO:0048535 9 7 0,000 0,05664432 0,12539166 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05664432 0,12527109 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05664432 0,12515076 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05664432 0,12503065 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05664432 0,12491077 ! ATP catabolic process GO:0006200 10 7 0,000 0,05664432 0,12479113 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05664432 0,12467171 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05664432 0,12455252 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05664432 0,12443356 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05664432 0,12431482 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05664432 0,12419632 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05664432 0,12407803 ! muscle adaptation GO:0043500 12 7 0,000 0,05664432 0,12395998 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05664432 0,12384214 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05664432 0,12372454 ! retina homeostasis GO:0001895 9 7 0,000 0,05664432 0,12360715 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05664432 0,12348999 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05664432 0,12337305 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05664432 0,12325633 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05664432 0,12313983 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05664432 0,12302355 ! viral infectious cycle GO:0019058 71 47 1,000 0,05795163 0,1257441 ! endocrine system development GO:0035270 83 47 1,000 0,05795163 0,12562558 ! covalent chromatin modification GO:0016569 75 47 1,000 0,05795163 0,12550729 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,05795163 0,12538922 ! response to temperature stimulus GO:0009266 62 48 1,000 0,06015128 0,13002627 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,06015128 0,12990418 ! regulation of DNA replication GO:0006275 75 48 1,000 0,06015128 0,12978232 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,06237931 0,13446337 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,06237931 0,13433747 ! germ cell development GO:0007281 68 49 1,000 0,06237931 0,1342118 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,06237931 0,13408637 ! cartilage development GO:0051216 70 49 1,000 0,06237931 0,13396117 ! maintenance of location GO:0051235 84 49 1,000 0,06237931 0,13383621 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06447188 0,13819694 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06447188 0,13806827 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,06447188 0,13793983 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,06447188 0,13781163 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06447188 0,13768368 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06447188 0,13755595 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06447188 0,13742847 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06447188 0,13730122 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06447188 0,13717421 ! phosphate transport GO:0006817 10 8 0,000 0,06447188 0,13704743 ! N-glycan processing GO:0006491 12 8 0,000 0,06447188 0,13692089 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06447188 0,13679457 ! UTP metabolic process GO:0046051 8 8 0,000 0,06447188 0,1366685 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06447188 0,13654265 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06447188 0,13641704 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06447188 0,13629165 ! succinate metabolic process GO:0006105 14 8 0,000 0,06447188 0,1361665 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,06447188 0,13604158 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,06447188 0,13591688 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06447188 0,13579242 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06447188 0,13566818 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06447188 0,13554417 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06447188 0,13542038 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06447188 0,13529682 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06447188 0,13517349 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06447188 0,13505038 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06447188 0,1349275 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06447188 0,13480484 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06447188 0,1346824 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06447188 0,13456018 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06447188 0,13443819 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06447188 0,13431641 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06447188 0,13419486 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06447188 0,13407353 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06447188 0,13395241 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06447188 0,13383152 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06447188 0,13371084 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06447188 0,13359038 ! melanin metabolic process GO:0006582 12 8 0,000 0,06447188 0,13347013 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06447188 0,13335011 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06447188 0,1332303 ! macrophage activation GO:0042116 12 8 0,000 0,06447188 0,1331107 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06447188 0,13299132 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06447188 0,13287215 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,06447188 0,1327532 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06447188 0,13263445 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06447188 0,13251592 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06447188 0,13239761 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06447188 0,1322795 ! ruffle organization GO:0031529 11 8 0,000 0,06447188 0,1321616 ! osteoblast development GO:0002076 13 8 0,000 0,06447188 0,13204392 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06447188 0,13192644 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06447188 0,13180917 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06447188 0,13169211 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06447188 0,13157526 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06447188 0,13145862 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06447188 0,13134218 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06447188 0,13122595 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06447188 0,13110992 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06447188 0,1309941 ! brain morphogenesis GO:0048854 20 8 0,000 0,06447188 0,13087848 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06447188 0,13076307 ! segment specification GO:0007379 10 8 0,000 0,06447188 0,13064786 ! cellular extravasation GO:0045123 11 8 0,000 0,06447188 0,13053285 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06447188 0,13041805 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06447188 0,13030344 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06447188 0,13018904 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06447188 0,13007484 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06447188 0,12996084 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,06447188 0,12984704 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06447188 0,12973344 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,06447188 0,12962003 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06447188 0,12950683 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06447188 0,12939382 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06447188 0,12928101 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06447188 0,1291684 ! icosanoid secretion GO:0032309 12 8 0,000 0,06447188 0,12905598 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06447188 0,12894376 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06447188 0,12883173 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06447188 0,1287199 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06447188 0,12860826 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06447188 0,12849681 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06447188 0,12838556 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06447188 0,1282745 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06447188 0,12816363 ! sterol catabolic process GO:0016127 9 8 0,000 0,06447188 0,12805295 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06447188 0,12794247 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06447188 0,12783217 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06447188 0,12772207 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06447188 0,12761215 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06447188 0,12750242 ! prophase GO:0051324 11 8 0,000 0,06447188 0,12739289 ! S phase GO:0051320 8 8 0,000 0,06447188 0,12728354 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06447188 0,12717437 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06447188 0,1270654 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06447188 0,12695661 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06447188 0,12684801 ! hormone catabolic process GO:0042447 13 8 0,000 0,06447188 0,12673959 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06447188 0,12663136 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06447188 0,12652331 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06447188 0,12641545 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06447188 0,12630777 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06447188 0,12620027 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06447188 0,12609296 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06447188 0,12598583 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06447188 0,12587888 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06447188 0,12577211 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06447188 0,12566552 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06447188 0,12555912 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06447188 0,12545289 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06447188 0,12534685 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,0646351 0,12555805 ! lipid modification GO:0030258 73 50 1,000 0,0646351 0,1254521 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,0646351 0,12534632 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,0646351 0,12524072 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,06691804 0,12955514 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,06691804 0,12944618 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,06691804 0,1293374 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,06922754 0,13368879 ! aging GO:0007568 79 52 1,000 0,06922754 0,13357664 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,06922754 0,13346467 ! establishment of organelle localization GO:0051656 85 52 1,000 0,06922754 0,13335289 ! regulation of neurotransmitter levels GO:0001505 73 53 1,000 0,07156301 0,13773633 ! cell projection assembly GO:0030031 76 53 1,000 0,07156301 0,13762117 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,07223493 0,13879728 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07223493 0,13868142 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07223493 0,13856575 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07223493 0,13845028 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07223493 0,138335 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,07223493 0,13821992 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,07223493 0,13810502 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07223493 0,13799032 ! GTP metabolic process GO:0046039 9 9 0,000 0,07223493 0,1378758 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07223493 0,13776148 ! social behavior GO:0035176 14 9 0,000 0,07223493 0,13764734 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07223493 0,13753339 ! artery development GO:0060840 19 9 0,000 0,07223493 0,13741964 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,07223493 0,13730607 ! response to pain GO:0048265 16 9 0,000 0,07223493 0,13719268 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,07223493 0,13707949 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07223493 0,13696648 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07223493 0,13685366 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07223493 0,13674102 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,07223493 0,13662857 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07223493 0,1365163 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07223493 0,13640422 ! ventral spinal cord development GO:0021517 11 9 0,000 0,07223493 0,13629232 ! protein targeting to ER GO:0045047 19 9 0,000 0,07223493 0,13618061 ! endoderm development GO:0007492 12 9 0,000 0,07223493 0,13606907 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07223493 0,13595772 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07223493 0,13584656 ! arginine catabolic process GO:0006527 10 9 0,000 0,07223493 0,13573557 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07223493 0,13562477 ! L-serine metabolic process GO:0006563 13 9 0,000 0,07223493 0,13551414 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,07223493 0,1354037 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,07223493 0,13529344 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07223493 0,13518335 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07223493 0,13507345 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07223493 0,13496372 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07223493 0,13485417 ! mannose metabolic process GO:0006013 9 9 0,000 0,07223493 0,1347448 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,07223493 0,13463561 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07223493 0,13452659 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07223493 0,13441775 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,07223493 0,13430909 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07223493 0,1342006 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07223493 0,13409228 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,07223493 0,13398414 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,07223493 0,13387618 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07223493 0,13376839 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,07223493 0,13366077 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07223493 0,13355333 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07223493 0,13344606 ! DNA ligation GO:0006266 14 9 0,000 0,07223493 0,13333896 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07223493 0,13323203 ! response to amine stimulus GO:0014075 13 9 0,000 0,07223493 0,13312527 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07223493 0,13301869 ! erythrocyte development GO:0048821 11 9 0,000 0,07223493 0,13291227 ! renal water homeostasis GO:0003091 14 9 0,000 0,07223493 0,13280603 ! mRNA cleavage GO:0006379 13 9 0,000 0,07223493 0,13269995 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07223493 0,13259405 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,07223493 0,13248831 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07223493 0,13238274 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07223493 0,13227734 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07223493 0,13217211 ! acid secretion GO:0046717 14 9 0,000 0,07223493 0,13206704 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07223493 0,13196214 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07223493 0,13185741 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07223493 0,13175285 ! purine base metabolic process GO:0006144 18 9 0,000 0,07223493 0,13164845 ! oocyte differentiation GO:0009994 12 9 0,000 0,07223493 0,13154421 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,07223493 0,13144014 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07223493 0,13133624 ! spleen development GO:0048536 15 9 0,000 0,07223493 0,1312325 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07223493 0,13112892 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07223493 0,1310255 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07223493 0,13092225 ! detection of calcium ion GO:0005513 13 9 0,000 0,07223493 0,13081917 ! blastocyst formation GO:0001825 12 9 0,000 0,07223493 0,13071624 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07223493 0,13061347 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07223493 0,13051087 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07223493 0,13040843 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,07223493 0,13030615 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07223493 0,13020403 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07223493 0,13010207 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07223493 0,13000027 ! prepulse inhibition GO:0060134 14 9 0,000 0,07223493 0,12989862 ! embryonic placenta development GO:0001892 12 9 0,000 0,07223493 0,12979714 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07223493 0,12969582 ! insulin secretion GO:0030073 17 9 0,000 0,07223493 0,12959465 ! sequestering of metal ion GO:0051238 11 9 0,000 0,07223493 0,12949364 ! response to nicotine GO:0035094 16 9 0,000 0,07223493 0,12939279 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07223493 0,12929209 ! nucleus localization GO:0051647 15 9 0,000 0,07223493 0,12919155 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,07392385 0,13210945 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,07392385 0,13200688 ! detection of external stimulus GO:0009581 66 54 1,000 0,07392385 0,13190447 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,07392385 0,13180222 ! exocytosis GO:0006887 74 55 1,000 0,07630951 0,13595033 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,0787194 0,14013516 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07993401 0,14218733 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07993401 0,14207744 ! neuron fate specification GO:0048665 11 10 0,000 0,07993401 0,14196773 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07993401 0,14185819 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07993401 0,14174881 ! thyroid gland development GO:0030878 19 10 0,000 0,07993401 0,14163961 ! synapsis GO:0007129 13 10 0,000 0,07993401 0,14153057 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07993401 0,1414217 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07993401 0,141313 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07993401 0,14120446 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,07993401 0,1410961 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07993401 0,14098789 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07993401 0,14087986 ! androgen metabolic process GO:0008209 13 10 0,000 0,07993401 0,14077198 ! phospholipid efflux GO:0033700 16 10 0,000 0,07993401 0,14066428 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07993401 0,14055674 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07993401 0,14044936 ! pathogenesis GO:0009405 13 10 0,000 0,07993401 0,14034215 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07993401 0,1402351 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07993401 0,14012821 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07993401 0,14002149 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07993401 0,13991493 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07993401 0,13980853 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07993401 0,13970229 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07993401 0,13959621 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07993401 0,1394903 ! response to X-ray GO:0010165 16 10 0,000 0,07993401 0,13938454 ! B cell proliferation GO:0042100 14 10 0,000 0,07993401 0,13927895 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07993401 0,13917351 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07993401 0,13906824 ! forebrain cell migration GO:0021885 17 10 0,000 0,07993401 0,13896312 ! lipid digestion GO:0044241 15 10 0,000 0,07993401 0,13885817 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07993401 0,13875337 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07993401 0,13864873 ! UV protection GO:0009650 14 10 0,000 0,07993401 0,13854424 ! entry into host cell GO:0030260 20 10 0,000 0,07993401 0,13843992 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07993401 0,13833575 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07993401 0,13823174 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07993401 0,13812788 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07993401 0,13802418 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,07993401 0,13792064 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07993401 0,13781725 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07993401 0,13771402 ! regulation of organ growth GO:0046620 11 10 0,000 0,07993401 0,13761094 ! response to dsRNA GO:0043331 18 10 0,000 0,07993401 0,13750801 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07993401 0,13740524 ! embryonic axis specification GO:0000578 12 10 0,000 0,07993401 0,13730262 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07993401 0,13720016 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07993401 0,13709785 ! fucose catabolic process GO:0019317 16 10 0,000 0,07993401 0,13699569 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07993401 0,13689368 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07993401 0,13679182 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07993401 0,13669012 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07993401 0,13658857 ! zymogen activation GO:0031638 14 10 0,000 0,07993401 0,13648717 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07993401 0,13638591 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07993401 0,13628481 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07993401 0,13618386 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07993401 0,13608306 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07993401 0,13598241 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07993401 0,1358819 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07993401 0,13578154 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07993401 0,13568134 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07993401 0,13558128 ! detection of bacterium GO:0016045 10 10 0,000 0,07993401 0,13548136 ! embryonic gut development GO:0048566 11 10 0,000 0,07993401 0,1353816 ! activation of innate immune response GO:0002218 10 10 0,000 0,07993401 0,13528198 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07993401 0,13518251 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07993401 0,13508318 ! developmental induction GO:0031128 13 10 0,000 0,07993401 0,134984 GO:0045168|cell-cell signaling involved in cell fate specification, ! chromosome segregation GO:0007059 83 57 1,000 0,08115298 0,13694193 ! rRNA transcription GO:0009303 17 11 0,000 0,08756963 0,14766139 ! respiratory burst GO:0045730 14 11 0,000 0,08756963 0,14755322 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,08756963 0,1474452 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08756963 0,14733734 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,08756963 0,14722963 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,08756963 0,14712209 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08756963 0,1470147 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08756963 0,14690747 ! mating GO:0007618 14 11 0,000 0,08756963 0,14680039 ! bone resorption GO:0045453 16 11 0,000 0,08756963 0,14669347 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08756963 0,14658671 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08756963 0,1464801 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,08756963 0,14637365 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,08756963 0,14626735 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08756963 0,1461612 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,08756963 0,14605521 ! syncytium formation GO:0006949 15 11 0,000 0,08756963 0,14594938 ! plasma membrane organization GO:0007009 18 11 0,000 0,08756963 0,14584369 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08756963 0,14573816 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08756963 0,14563278 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,08756963 0,14552756 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08756963 0,14542248 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08756963 0,14531756 ! adult heart development GO:0007512 11 11 0,000 0,08756963 0,14521279 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,08756963 0,14510817 ! temperature homeostasis GO:0001659 16 11 0,000 0,08756963 0,1450037 ! L-glutamate transport GO:0015813 16 11 0,000 0,08756963 0,14489938 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,08756963 0,14479521 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08756963 0,14469119 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08756963 0,14458732 ! stem cell development GO:0048864 29 11 0,000 0,08756963 0,1444836 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08756963 0,14438003 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08756963 0,1442766 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08756963 0,14417333 ! vasoconstriction GO:0042310 15 11 0,000 0,08756963 0,1440702 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08756963 0,14396722 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08756963 0,14386439 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08756963 0,1437617 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08756963 0,14365916 ! ribosome assembly GO:0042255 13 11 0,000 0,08756963 0,14355676 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08756963 0,14345452 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08756963 0,14335241 ! chromatin silencing GO:0006342 19 11 0,000 0,08756963 0,14325046 ! nucleosome positioning GO:0016584 13 11 0,000 0,08756963 0,14314864 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08756963 0,14304697 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08756963 0,14294545 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08756963 0,14284407 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08756963 0,14274283 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08756963 0,14264174 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08756963 0,14254079 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08756963 0,14243999 ! male genitalia development GO:0030539 13 11 0,000 0,08756963 0,14233932 ! cholesterol efflux GO:0033344 19 11 0,000 0,08756963 0,1422388 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,08756963 0,14213842 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08756963 0,14203818 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08756963 0,14193808 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,08756963 0,14183813 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,08756963 0,14173831 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08756963 0,14163864 ! defense response to fungus GO:0050832 12 11 0,000 0,08756963 0,1415391 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08756963 0,14143971 ! lysogeny GO:0030069 18 11 0,000 0,08756963 0,14134045 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08756963 0,14124133 ! acrosome reaction GO:0007340 13 11 0,000 0,08756963 0,14114235 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08756963 0,14104352 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,08859031 0,14258762 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,08859031 0,14248791 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,08859031 0,14238833 ! regulation of heart contraction GO:0008016 91 60 1,000 0,08859031 0,1422889 ! extracellular matrix organization GO:0030198 103 61 1,000 0,09111316 0,14623884 ! neurotransmitter transport GO:0006836 81 62 1,000 0,093657 0,15021695 ! organelle localization GO:0051640 96 62 1,000 0,093657 0,15011227 ! lactation GO:0007595 20 12 0,000 0,09514231 0,15238671 ! reproductive cellular process GO:0048610 14 12 0,000 0,09514231 0,15228067 ! tRNA modification GO:0006400 14 12 0,000 0,09514231 0,15217477 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,09514231 0,15206902 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,09514231 0,15196342 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,09514231 0,15185796 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,09514231 0,15175265 ! non-recombinational repair GO:0000726 19 12 0,000 0,09514231 0,15164748 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,09514231 0,15154246 ! peroxisomal transport GO:0043574 21 12 0,000 0,09514231 0,15143759 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,09514231 0,15133286 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,09514231 0,15122828 ! heart looping GO:0001947 15 12 0,000 0,09514231 0,15112384 ! palate development GO:0060021 15 12 0,000 0,09514231 0,15101954 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,09514231 0,15091539 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,09514231 0,15081138 ! arginine metabolic process GO:0006525 13 12 0,000 0,09514231 0,15070752 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,09514231 0,1506038 ! methionine metabolic process GO:0006555 13 12 0,000 0,09514231 0,15050022 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,09514231 0,15039678 ! Golgi organization GO:0007030 18 12 0,000 0,09514231 0,15029349 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,09514231 0,15019034 ! monoamine transport GO:0015844 13 12 0,000 0,09514231 0,15008732 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,09514231 0,14998445 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,09514231 0,14988173 ! L-amino acid transport GO:0015807 20 12 0,000 0,09514231 0,14977914 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,09514231 0,14967669 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,09514231 0,14957438 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,09514231 0,14947221 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,09514231 0,14937018 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,09514231 0,14926829 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,09514231 0,14916654 ! cerebellum development GO:0021549 13 12 0,000 0,09514231 0,14906493 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,09514231 0,14896346 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,09514231 0,14886212 ! histone methylation GO:0016571 15 12 0,000 0,09514231 0,14876092 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,09514231 0,14865986 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,09514231 0,14855894 ! response to gamma radiation GO:0010332 20 12 0,000 0,09514231 0,14845815 ! intestinal absorption GO:0050892 19 12 0,000 0,09514231 0,1483575 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,09514231 0,14825699 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,09514231 0,14815661 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,09514231 0,14805637 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,09514231 0,14795627 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,09514231 0,1478563 ! microspike assembly GO:0030035 23 12 0,000 0,09514231 0,14775646 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,09514231 0,14765676 ! response to cold GO:0009409 14 12 0,000 0,09514231 0,14755719 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,09622133 0,14913009 ! regulation of lipase activity GO:0060191 109 63 1,000 0,09622133 0,14902966 ! adaptive immune response GO:0002250 94 64 1,000 0,09880562 0,15292929 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,10140938 0,15685378 ! activation of immune response GO:0002253 83 65 1,000 0,10140938 0,15674836 ! protein oligomerization GO:0051259 100 65 1,000 0,10140938 0,15664309 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,10265258 0,158457 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,10265258 0,15835073 ! cGMP metabolic process GO:0046068 16 13 0,000 0,10265258 0,15824459 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,10265258 0,1581386 ! water transport GO:0006833 17 13 0,000 0,10265258 0,15803275 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,10265258 0,15792705 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,10265258 0,15782148 ! lipid localization GO:0010876 24 13 0,000 0,10265258 0,15771605 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,10265258 0,15761077 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,10265258 0,15750563 ! organelle fusion GO:0048284 28 13 0,000 0,10265258 0,15740062 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,10265258 0,15729576 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,10265258 0,15719103 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,10265258 0,15708645 ! response to hexose stimulus GO:0009746 19 13 0,000 0,10265258 0,156982 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,10265258 0,1568777 ! glutamate metabolic process GO:0006536 18 13 0,000 0,10265258 0,15677353 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,10265258 0,1566695 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,10265258 0,15656561 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,10265258 0,15646185 ! NAD metabolic process GO:0019674 21 13 0,000 0,10265258 0,15635823 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,10265258 0,15625475 ! bone mineralization GO:0030282 15 13 0,000 0,10265258 0,15615141 ! regulation of exocytosis GO:0017157 17 13 0,000 0,10265258 0,1560482 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,10265258 0,15594513 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,10265258 0,1558422 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,10265258 0,1557394 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,10265258 0,15563674 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,10265258 0,15553421 ! genitalia development GO:0048806 15 13 0,000 0,10265258 0,15543182 ! regulation of cellular pH GO:0030641 20 13 0,000 0,10265258 0,15532956 ! tissue regeneration GO:0042246 21 13 0,000 0,10265258 0,15522744 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,10265258 0,15512545 ! cofactor transport GO:0051181 19 13 0,000 0,10265258 0,15502359 ! NADP metabolic process GO:0006739 18 13 0,000 0,10265258 0,15492187 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,10265258 0,15482028 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,10265258 0,15471883 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,10265258 0,15461751 ! gas transport GO:0015669 18 13 0,000 0,10265258 0,15451632 ! heme biosynthetic process GO:0006783 20 13 0,000 0,10265258 0,15441526 ! regulation of axon extension GO:0030516 23 13 0,000 0,10265258 0,15431434 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,10265258 0,15421354 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,10265258 0,15411288 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,10265258 0,15401235 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,10265258 0,15391195 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,10265258 0,15381168 ! regulation of immune effector process GO:0002697 101 66 1,000 0,10403211 0,15577724 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,10667332 0,15962826 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,10933254 0,16350119 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,11010094 0,16454331 ! superoxide anion generation GO:0042554 18 14 0,000 0,11010094 0,16443647 ! neuron maturation GO:0042551 21 14 0,000 0,11010094 0,16432976 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,11010094 0,16422319 ! myotube differentiation GO:0014902 21 14 0,000 0,11010094 0,16411676 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,11010094 0,16401046 ! inositol metabolic process GO:0006020 20 14 0,000 0,11010094 0,16390431 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,11010094 0,16379829 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,11010094 0,16369241 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,11010094 0,16358667 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,11010094 0,16348106 ! gene silencing by RNA GO:0031047 20 14 0,000 0,11010094 0,16337559 ! response to cAMP GO:0051591 19 14 0,000 0,11010094 0,16327025 ! startle response GO:0001964 21 14 0,000 0,11010094 0,16316505 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,11010094 0,16305999 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,11010094 0,16295506 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,11010094 0,16285026 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,11010094 0,1627456 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,11010094 0,16264108 ! glycine metabolic process GO:0006544 22 14 0,000 0,11010094 0,16253669 ! pituitary gland development GO:0021983 23 14 0,000 0,11010094 0,16243243 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,11010094 0,16232831 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,11010094 0,16222432 ! regulation of heart rate GO:0002027 23 14 0,000 0,11010094 0,16212046 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,11010094 0,16201674 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,11010094 0,16191314 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,11010094 0,16180969 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,11010094 0,16170636 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,11010094 0,16160316 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,11010094 0,1615001 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,11010094 0,16139717 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,11010094 0,16129437 ! axon cargo transport GO:0008088 27 14 0,000 0,11010094 0,1611917 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,11010094 0,16108916 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,11010094 0,16098675 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,11010094 0,16088447 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,11010094 0,16078232 ! mRNA splice site selection GO:0006376 26 14 0,000 0,11010094 0,1606803 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,11010094 0,16057841 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,11010094 0,16047665 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,11010094 0,16037502 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,11010094 0,16027352 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,11010094 0,16017214 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,11010094 0,1600709 ! muscle maintenance GO:0046716 19 14 0,000 0,11010094 0,15996978 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,11010094 0,15986879 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,11010094 0,15976792 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,11010094 0,15966719 ! cell killing GO:0001906 20 14 0,000 0,11010094 0,15956658 ! cilium assembly GO:0042384 20 14 0,000 0,11010094 0,15946609 ! peptide hormone secretion GO:0030072 23 14 0,000 0,11010094 0,15936574 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,11200928 0,162026 ! response to drug GO:0042493 108 69 1,000 0,11200928 0,16192416 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,11470308 0,16571425 ! eye development GO:0001654 111 70 1,000 0,11470308 0,16561022 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,11470308 0,16550633 ! muscle cell differentiation GO:0042692 104 71 1,000 0,11741348 0,16931097 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,11741348 0,16920489 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,11741348 0,16909894 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,1174879 0,16910022 ! metencephalon development GO:0022037 19 15 0,000 0,1174879 0,16899447 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,1174879 0,16888885 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,1174879 0,16878336 ! skin development GO:0043588 25 15 0,000 0,1174879 0,168678 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,1174879 0,16857278 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,1174879 0,16846768 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,1174879 0,16836272 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,1174879 0,16825788 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,1174879 0,16815318 ! bile acid metabolic process GO:0008206 22 15 0,000 0,1174879 0,16804861 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,1174879 0,16794416 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,1174879 0,16783985 ! adult walking behavior GO:0007628 25 15 0,000 0,1174879 0,16773567 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,1174879 0,16763161 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,1174879 0,16752769 ! myoblast differentiation GO:0045445 27 15 0,000 0,1174879 0,16742389 ! centrosome cycle GO:0007098 16 15 0,000 0,1174879 0,16732022 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,1174879 0,16721668 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,1174879 0,16711327 ! cerebral cortex development GO:0021987 29 15 0,000 0,1174879 0,16700999 ! response to osmotic stress GO:0006970 22 15 0,000 0,1174879 0,16690683 ! vesicle coating GO:0006901 25 15 0,000 0,1174879 0,1668038 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,1174879 0,1667009 ! DNA integration GO:0015074 22 15 0,000 0,1174879 0,16659812 ! peptide secretion GO:0002790 27 15 0,000 0,1174879 0,16649548 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,1174879 0,16639295 ! regulation of vasodilation GO:0042312 24 15 0,000 0,1174879 0,16629056 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,1174879 0,16618829 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,1174879 0,16608615 ! biomineral formation GO:0031214 18 15 0,000 0,1174879 0,16598413 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,1174879 0,16588223 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,1174879 0,16578047 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,1174879 0,16567882 ! organic cation transport GO:0015695 19 15 0,000 0,1174879 0,1655773 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,1174879 0,16547591 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,1174879 0,16537464 ! peptide hormone processing GO:0016486 19 15 0,000 0,1174879 0,16527349 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,1174879 0,16517247 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,12014002 0,16879783 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,12014002 0,16869477 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,12014002 0,16859185 ! negative regulation of transport GO:0051051 116 73 1,000 0,12288225 0,17233486 ! tube morphogenesis GO:0035239 118 73 1,000 0,12288225 0,17222984 ! protein secretion GO:0009306 27 16 0,000 0,12481395 0,17483075 ! hormone secretion GO:0046879 25 16 0,000 0,12481395 0,17472434 ! bone remodeling GO:0046849 24 16 0,000 0,12481395 0,17461806 ! endothelial cell migration GO:0043542 22 16 0,000 0,12481395 0,17451191 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,12481395 0,17440589 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,12481395 0,1743 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,12481395 0,17419423 ! glial cell development GO:0021782 24 16 0,000 0,12481395 0,17408859 ! patterning of blood vessels GO:0001569 24 16 0,000 0,12481395 0,17398309 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,12481395 0,17387771 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,12481395 0,17377245 ! protein polyubiquitination GO:0000209 26 16 0,000 0,12481395 0,17366733 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,12481395 0,17356233 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,12481395 0,17345746 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,12481395 0,17335271 ! fructose metabolic process GO:0006000 20 16 0,000 0,12481395 0,17324809 ! regulation of protein binding GO:0043393 27 16 0,000 0,12481395 0,1731436 ! protein export from nucleus GO:0006611 24 16 0,000 0,12481395 0,17303924 ! DNA replication initiation GO:0006270 25 16 0,000 0,12481395 0,172935 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,12481395 0,17283088 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,12481395 0,17272689 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,12481395 0,17262303 ! diencephalon development GO:0021536 25 16 0,000 0,12481395 0,17251929 ! oogenesis GO:0048477 23 16 0,000 0,12481395 0,17241567 ! neural crest cell migration GO:0001755 24 16 0,000 0,12481395 0,17231218 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,12481395 0,17220881 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,12481395 0,17210557 ! steroid catabolic process GO:0006706 22 16 0,000 0,12481395 0,17200245 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,12481395 0,17189946 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,12481395 0,17179658 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,12481395 0,17169383 ! sperm-egg recognition GO:0035036 16 16 0,000 0,12481395 0,17159121 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,12481395 0,1714887 ! negative regulation of translation GO:0017148 22 16 0,000 0,12481395 0,17138632 ! response to nutrient GO:0007584 104 75 1,000 0,12841202 0,17622174 ! amine biosynthetic process GO:0009309 97 76 1,000 0,13119869 0,17993857 ! regulation of protein transport GO:0051223 114 76 1,000 0,13119869 0,17983134 GO:0070201|regulation of establishment of protein localization, ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,13207961 0,18093097 ! negative regulation of defense response GO:0031348 19 17 0,000 0,13207961 0,18082328 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,13207961 0,18071571 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,13207961 0,18060827 ! glycerol metabolic process GO:0006071 20 17 0,000 0,13207961 0,18050095 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,13207961 0,18039377 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,13207961 0,18028671 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,13207961 0,18017978 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,13207961 0,18007297 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,13207961 0,17996629 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,13207961 0,17985974 ! memory GO:0007613 25 17 0,000 0,13207961 0,17975332 ! keratinization GO:0031424 17 17 0,000 0,13207961 0,17964702 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,13207961 0,17954084 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,13207961 0,17943479 ! retinoid metabolic process GO:0001523 22 17 0,000 0,13207961 0,17932887 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,13207961 0,17922307 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,13207961 0,1791174 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,13207961 0,17901185 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,13207961 0,17890642 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,13207961 0,17880112 ! membrane budding GO:0006900 29 17 0,000 0,13207961 0,17869594 ! heme metabolic process GO:0042168 27 17 0,000 0,13207961 0,17859089 ! body fluid secretion GO:0007589 27 17 0,000 0,13207961 0,17848596 ! stem cell differentiation GO:0048863 36 17 0,000 0,13207961 0,17838115 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,13207961 0,17827647 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,13207961 0,17817191 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,13207961 0,17806747 ! sensory perception of pain GO:0019233 23 17 0,000 0,13207961 0,17796315 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,13207961 0,17785896 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,13207961 0,17775489 ! synaptogenesis GO:0007416 24 17 0,000 0,13207961 0,17765094 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,13207961 0,17754711 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,13207961 0,1774434 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,13207961 0,17733982 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,13207961 0,17723635 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,13207961 0,17713301 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,13399932 0,17960282 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,13399932 0,17949821 ! sex differentiation GO:0007548 105 77 1,000 0,13399932 0,17939373 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,13399932 0,17928937 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,13399932 0,17918513 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,13681348 0,18284196 ! positive regulation of translation GO:0045727 28 18 0,000 0,13928536 0,18603736 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,13928536 0,18592939 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,13928536 0,18582154 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,13928536 0,18571382 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,13928536 0,18560622 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13928536 0,18549875 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13928536 0,1853914 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13928536 0,18528417 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13928536 0,18517707 ! axis specification GO:0009798 26 18 0,000 0,13928536 0,18507009 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13928536 0,18496324 GO:0050886|endocrine process, ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13928536 0,18485651 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13928536 0,1847499 ! pigmentation during development GO:0048066 31 18 0,000 0,13928536 0,18464342 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13928536 0,18453706 ! fucose metabolic process GO:0006004 26 18 0,000 0,13928536 0,18443082 ! response to fungus GO:0009620 19 18 0,000 0,13928536 0,1843247 ! peptide cross-linking GO:0018149 31 18 0,000 0,13928536 0,18421871 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,13928536 0,18411284 ! heart process GO:0003015 27 18 0,000 0,13928536 0,18400708 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,13928536 0,18390145 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,13928536 0,18379595 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13928536 0,18369056 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13928536 0,18358529 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13928536 0,18348015 ! vitamin transport GO:0051180 24 18 0,000 0,13928536 0,18337512 ! hormone transport GO:0009914 27 18 0,000 0,13928536 0,18327021 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,13928536 0,18316543 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13928536 0,18306076 ! cell-cell recognition GO:0009988 20 18 0,000 0,13928536 0,18295622 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13928536 0,18285179 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13928536 0,18274748 ! regulation of glucose import GO:0046324 21 18 0,000 0,13928536 0,18264329 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,13928536 0,18253922 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,13928536 0,18243527 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,13964077 0,18279669 ! T cell activation GO:0042110 134 79 1,000 0,13964077 0,18269271 ! regulation of lyase activity GO:0051339 133 79 1,000 0,13964077 0,18258885 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,14533311 0,18992395 ! regulation of neurological system process GO:0031644 122 81 1,000 0,14533311 0,1898161 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1464317 0,1911424 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1464317 0,19103398 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,1464317 0,19092568 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,1464317 0,19081751 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,1464317 0,19070946 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,1464317 0,19060153 ! regeneration GO:0031099 32 19 0,000 0,1464317 0,19049373 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1464317 0,19038604 ! sensory perception of taste GO:0050909 23 19 0,000 0,1464317 0,19027848 ! smooth muscle contraction GO:0006939 36 19 0,000 0,1464317 0,19017104 ! peroxisome organization GO:0007031 29 19 0,000 0,1464317 0,19006372 ! digestive system process GO:0022600 30 19 0,000 0,1464317 0,18995652 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,1464317 0,18984944 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1464317 0,18974248 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,1464317 0,18963565 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,1464317 0,18952893 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1464317 0,18942233 ! plasma membrane fusion GO:0045026 23 19 0,000 0,1464317 0,18931586 ! cytolysis GO:0019835 20 19 0,000 0,1464317 0,1892095 ! renal system process GO:0003014 35 19 0,000 0,1464317 0,18910326 ! vasodilation GO:0042311 33 19 0,000 0,1464317 0,18899714 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,1464317 0,18889114 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1464317 0,18878526 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1464317 0,1886795 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,1464317 0,18857386 ! sarcomere organization GO:0045214 23 19 0,000 0,1464317 0,18846833 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,1464317 0,18836292 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1464317 0,18825763 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1464317 0,18815246 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,1464317 0,18804741 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,1464317 0,18794247 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1464317 0,18783765 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,1464317 0,18773295 ! detection of stimulus GO:0051606 108 82 1,000 0,14819735 0,18989076 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,15107313 0,19346782 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,15107313 0,19336015 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,15351911 0,19638151 ! iron ion transport GO:0006826 37 20 0,000 0,15351911 0,19627234 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,15351911 0,1961633 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,15351911 0,19605438 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,15351911 0,19594559 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,15351911 0,19583691 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,15351911 0,19572835 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,15351911 0,19561991 ! spinal cord development GO:0021510 31 20 0,000 0,15351911 0,1955116 ! response to ethanol GO:0045471 37 20 0,000 0,15351911 0,1954034 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,15351911 0,19529532 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,15351911 0,19518737 ! chromosome condensation GO:0030261 31 20 0,000 0,15351911 0,19507953 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,15351911 0,19497181 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,15351911 0,19486421 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,15351911 0,19475673 ! DNA modification GO:0006304 28 20 0,000 0,15351911 0,19464936 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,15351911 0,19454212 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,15351911 0,19443499 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,15351911 0,19432798 ! collagen catabolic process GO:0030574 25 20 0,000 0,15351911 0,19422109 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,15351911 0,19411432 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,15351911 0,19400766 ! alditol metabolic process GO:0019400 24 20 0,000 0,15351911 0,19390112 ! actin filament-based movement GO:0030048 34 20 0,000 0,15351911 0,1937947 ! sterol metabolic process GO:0016125 120 84 1,000 0,15396005 0,19424472 ! rRNA metabolic process GO:0016072 107 85 1,000 0,15685774 0,19779211 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,15685774 0,19768373 ! regulation of protein localization GO:0032880 132 85 1,000 0,15685774 0,19757547 ! regulation of membrane potential GO:0042391 128 85 1,000 0,15685774 0,19746733 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,15685774 0,1973593 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,15976583 0,20090837 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,16054807 0,20178173 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,16054807 0,20167152 GO:0016444|somatic cell DNA recombination, ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,16054807 0,20156144 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,16054807 0,20145148 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,16054807 0,20134163 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,16054807 0,20123191 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,16054807 0,20112231 ! vesicle docking GO:0048278 27 21 0,000 0,16054807 0,20101282 ! phototransduction GO:0007602 25 21 0,000 0,16054807 0,20090346 ! dendrite development GO:0016358 35 21 0,000 0,16054807 0,20079421 ! visual behavior GO:0007632 39 21 0,000 0,16054807 0,20068509 ! ovarian follicle development GO:0001541 30 21 0,000 0,16054807 0,20057608 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,16054807 0,20046719 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,16054807 0,20035841 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,16054807 0,20024976 ! cell aging GO:0007569 32 21 0,000 0,16054807 0,20014122 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,16054807 0,20003281 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,16054807 0,1999245 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,16054807 0,19981632 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,16054807 0,19970825 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,16054807 0,1996003 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,16054807 0,19949247 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,16054807 0,19938475 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,16054807 0,19927715 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,16054807 0,19916966 ! fatty acid transport GO:0015908 30 21 0,000 0,16054807 0,1990623 ! platelet activation GO:0030168 28 21 0,000 0,16054807 0,19895504 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,16054807 0,1988479 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,16054807 0,19874088 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,16054807 0,19863397 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,16054807 0,19852718 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,16054807 0,1984205 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,16054807 0,19831394 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,16054807 0,19820749 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,16054807 0,19810116 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,16054807 0,19799494 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,16054807 0,19788883 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,16054807 0,19778284 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,16054807 0,19767696 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,16561171 0,20380254 ! protein processing GO:0016485 114 88 1,000 0,16561171 0,20369355 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,16751906 0,20592937 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,16751906 0,20581936 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,16751906 0,20570947 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,16751906 0,2055997 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,16751906 0,20549005 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,16751906 0,20538051 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,16751906 0,20527109 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,16751906 0,20516179 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,16751906 0,20505261 ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,16751906 0,20494353 ! lysosome organization GO:0007040 37 22 0,000 0,16751906 0,20483458 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,16751906 0,20472574 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,16751906 0,20461702 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,16751906 0,20450841 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,16751906 0,20439992 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,16751906 0,20429154 ! membrane depolarization GO:0051899 35 22 0,000 0,16751906 0,20418328 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,16751906 0,20407513 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,16751906 0,2039671 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,16751906 0,20385918 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,16751906 0,20375137 ! blastocyst development GO:0001824 37 22 0,000 0,16751906 0,20364368 ! neural tube closure GO:0001843 33 22 0,000 0,16751906 0,2035361 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,16751906 0,20342864 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,16854879 0,2045711 ! leukocyte differentiation GO:0002521 143 90 1,000 0,17149483 0,20803698 ! hormone metabolic process GO:0042445 121 90 1,000 0,17149483 0,20792731 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,17443256 0,21137771 ! neuron fate commitment GO:0048663 32 23 0,000 0,17443256 0,2112664 ! embryonic pattern specification GO:0009880 31 23 0,000 0,17443256 0,21115521 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,17443256 0,21104413 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,17443256 0,21093317 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,17443256 0,21082233 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,17443256 0,21071161 ! vesicle targeting GO:0006903 32 23 0,000 0,17443256 0,210601 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,17443256 0,2104905 ! osteoblast differentiation GO:0001649 40 23 0,000 0,17443256 0,21038012 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,17443256 0,21026986 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,17443256 0,21015972 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,17443256 0,21004968 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,17443256 0,20993977 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,17443256 0,20982997 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,17443256 0,20972028 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,17443256 0,20961071 ! cell fate determination GO:0001709 45 23 0,000 0,17443256 0,20950125 ! pentose metabolic process GO:0019321 31 23 0,000 0,17443256 0,20939191 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,17443256 0,20928268 ! spermatid development GO:0007286 33 23 0,000 0,17443256 0,20917357 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,17443256 0,20906456 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,17443256 0,20895568 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,17443256 0,2088469 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,17443256 0,20873824 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,17443256 0,20862969 ! regulation of amine transport GO:0051952 38 23 0,000 0,17443256 0,20852126 ! liver development GO:0001889 40 23 0,000 0,17443256 0,20841293 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,17741238 0,21186317 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,17741238 0,21175323 ! DNA recombination GO:0006310 146 92 1,000 0,17741238 0,21164339 ! sulfur metabolic process GO:0006790 118 92 1,000 0,17741238 0,21153368 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,18038321 0,21496445 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,18128904 0,21593206 ! initiation of viral infection GO:0019059 42 24 0,000 0,18128904 0,21582029 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,18128904 0,21570864 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,18128904 0,21559711 ! superoxide metabolic process GO:0006801 32 24 0,000 0,18128904 0,21548569 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,18128904 0,21537438 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,18128904 0,21526319 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,18128904 0,21515212 ! sperm motility GO:0030317 27 24 0,000 0,18128904 0,21504116 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,18128904 0,21493031 ! vacuole organization GO:0007033 39 24 0,000 0,18128904 0,21481958 ! neural crest cell development GO:0014032 39 24 0,000 0,18128904 0,21470896 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,18128904 0,21459846 ! primary neural tube formation GO:0014020 35 24 0,000 0,18128904 0,21448807 ! base-excision repair GO:0006284 31 24 0,000 0,18128904 0,21437779 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,18128904 0,21426763 ! response to oxidative stress GO:0006979 141 94 1,000 0,18336164 0,21660594 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,18808897 0,2220763 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,18808897 0,22196235 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,18808897 0,22184853 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,18808897 0,22173482 GO:0006479|protein amino acid methylation, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,18808897 0,22162122 ! peptide transport GO:0015833 43 25 0,000 0,18808897 0,22150775 ! male gonad development GO:0008584 33 25 0,000 0,18808897 0,22139439 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,18808897 0,22128114 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,18808897 0,22116801 ! phospholipid transport GO:0015914 35 25 0,000 0,18808897 0,221055 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,18808897 0,2209421 ! detection of light stimulus GO:0009583 30 25 0,000 0,18808897 0,22082932 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,18933997 0,22218466 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,18933997 0,22207136 ! protein maturation GO:0051604 129 96 1,000 0,18933997 0,22195818 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,1948328 0,22828092 ! translational initiation GO:0006413 43 26 0,000 0,1948328 0,22816469 ! regulation of pH GO:0006885 36 26 0,000 0,1948328 0,22804857 ! circadian rhythm GO:0007623 42 26 0,000 0,1948328 0,22793258 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,1948328 0,2278167 ! post-embryonic development GO:0009791 42 26 0,000 0,1948328 0,22770094 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,1948328 0,22758529 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,1948328 0,22746977 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,1948328 0,22735436 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,1948328 0,22723907 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,1948328 0,2271239 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,1948328 0,22700884 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,1948328 0,2268939 ! regulation of coagulation GO:0050818 39 26 0,000 0,1948328 0,22677907 ! calcium ion transport GO:0006816 167 99 1,000 0,19835642 0,23076366 ! regulation of translation GO:0006417 151 100 1,000 0,20137371 0,23415548 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,20137371 0,23403716 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,20137371 0,23391896 ! divalent metal ion transport GO:0070838 171 100 1,000 0,20137371 0,23380088 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,201521 0,23385384 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,201521 0,23373591 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,201521 0,2336181 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,201521 0,23350041 ! membrane docking GO:0022406 39 27 0,000 0,201521 0,23338283 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,201521 0,23326538 ! acute-phase response GO:0006953 42 27 0,000 0,201521 0,23314804 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,201521 0,23303082 ! myofibril assembly GO:0030239 36 27 0,000 0,201521 0,23291372 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,201521 0,23279674 ! response to ionizing radiation GO:0010212 47 27 0,000 0,201521 0,23267987 ! natural killer cell activation GO:0030101 35 27 0,000 0,201521 0,23256313 ! lipid oxidation GO:0034440 38 27 0,000 0,201521 0,23244649 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,201521 0,23232998 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,201521 0,23221358 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,201521 0,2320973 ! gene silencing GO:0016458 41 27 0,000 0,201521 0,23198114 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,20815403 0,23949688 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,20815403 0,23937713 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,20815403 0,2392575 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,20815403 0,239138 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,20815403 0,23901861 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,20815403 0,23889933 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,20815403 0,23878018 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,20815403 0,23866115 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,20815403 0,23854224 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,20815403 0,23842344 ! response to organic cyclic substance GO:0014070 47 28 0,000 0,20815403 0,23830476 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,20815403 0,2381862 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,20815403 0,23806776 ! mesoderm formation GO:0001707 46 28 0,000 0,20815403 0,23794944 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,20815403 0,23783123 ! BMP signaling pathway GO:0030509 40 28 0,000 0,20815403 0,23771314 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,20815403 0,23759517 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,20815403 0,23747731 ! neural tube formation GO:0001841 41 28 0,000 0,20815403 0,23735958 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,21473233 0,24473952 ! regulation of innate immune response GO:0045088 38 29 0,000 0,21473233 0,24461831 ! ovulation cycle process GO:0022602 41 29 0,000 0,21473233 0,24449721 ! protein targeting to membrane GO:0006612 53 29 0,000 0,21473233 0,24437623 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,21473233 0,24425537 ! mismatch repair GO:0006298 34 29 0,000 0,21473233 0,24413463 ! muscle cell development GO:0055001 38 29 0,000 0,21473233 0,24401401 ! formation of primary germ layer GO:0001704 48 29 0,000 0,21473233 0,24389351 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,21473233 0,24377313 ! eye morphogenesis GO:0048592 51 29 0,000 0,21473233 0,24365287 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,21473233 0,24353272 ! tissue homeostasis GO:0001894 42 29 0,000 0,21473233 0,2434127 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,22125636 0,25068454 ! collagen metabolic process GO:0032963 40 30 0,000 0,22125636 0,25056111 ! organic anion transport GO:0015711 51 30 0,000 0,22125636 0,2504378 ! cholesterol transport GO:0030301 46 30 0,000 0,22125636 0,25031462 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,22125636 0,25019155 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,22125636 0,25006861 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,22125636 0,24994578 ! ceramide metabolic process GO:0006672 43 30 0,000 0,22125636 0,24982308 ! ovulation cycle GO:0042698 43 30 0,000 0,22125636 0,2497005 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,22125636 0,24957804 ! adult locomotory behavior GO:0008344 47 30 0,000 0,22125636 0,24945569 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,22125636 0,24933347 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,22125636 0,24921137 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,22125636 0,24908939 ! negative regulation of secretion GO:0051048 49 31 0,000 0,22772655 0,25624807 ! glial cell differentiation GO:0010001 55 31 0,000 0,22772655 0,25612277 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,22772655 0,25599759 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,22772655 0,25587253 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,22772655 0,25574759 ! odontogenesis GO:0042476 50 31 0,000 0,22772655 0,25562277 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,22772655 0,25549808 ! metanephros development GO:0001656 58 31 0,000 0,22772655 0,25537351 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,22772655 0,25524906 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,22772655 0,25512473 ! cell fate specification GO:0001708 37 31 0,000 0,22772655 0,25500052 ! RNA modification GO:0009451 40 31 0,000 0,22772655 0,25487643 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,23414335 0,26193079 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,23414335 0,26180346 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,23414335 0,26167625 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,23414335 0,26154916 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,23414335 0,26142219 ! cytokine production GO:0001816 44 32 0,000 0,23414335 0,26129535 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,23414335 0,26116863 ! vesicle localization GO:0051648 47 32 0,000 0,23414335 0,26104203 ! RNA export from nucleus GO:0006405 44 33 0,000 0,24050721 0,26800706 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,24050721 0,26787727 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,24050721 0,26774761 ! actomyosin structure organization GO:0031032 43 33 0,000 0,24050721 0,26761808 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,24050721 0,26748867 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,24050721 0,26735939 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,24050721 0,26723023 ! female gonad development GO:0008585 49 33 0,000 0,24050721 0,26710119 ! lipid homeostasis GO:0055088 55 33 0,000 0,24050721 0,26697228 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,24050721 0,2668435 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,24050721 0,26671484 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,24050721 0,2665863 ! mRNA catabolic process GO:0006402 48 34 0,000 0,24681854 0,27345021 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,24681854 0,27331856 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,24681854 0,27318703 ! feeding behavior GO:0007631 45 34 0,000 0,24681854 0,27305562 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,24681854 0,27292435 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,24681854 0,2727932 ! neuron migration GO:0001764 46 34 0,000 0,24681854 0,27266217 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,24681854 0,27253127 ! female gamete generation GO:0007292 43 34 0,000 0,24681854 0,2724005 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,24681854 0,27226985 ! polyol metabolic process GO:0019751 44 34 0,000 0,24681854 0,27213933 ! aerobic respiration GO:0009060 47 34 0,000 0,24681854 0,27200893 ! embryonic organ development GO:0048568 45 34 0,000 0,24681854 0,27187866 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,25307778 0,27863997 ! Notch signaling pathway GO:0007219 56 35 0,000 0,25307778 0,27850665 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,25307778 0,27837346 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,25307778 0,27824039 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,25307778 0,27810745 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,25307778 0,27797464 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,25307778 0,27784196 ! pigment metabolic process GO:0042440 61 35 0,000 0,25307778 0,2777094 ! protein homooligomerization GO:0051260 52 35 0,000 0,25307778 0,27757697 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,25928537 0,28424993 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,25928537 0,28411451 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,25928537 0,28397921 ! organic ether metabolic process GO:0018904 46 36 0,000 0,25928537 0,28384405 ! neural tube development GO:0021915 50 36 0,000 0,25928537 0,28370901 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,25928537 0,28357411 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,25928537 0,28343933 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,25928537 0,28330468 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,25928537 0,28317016 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,26544171 0,28975602 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,26544171 0,28961857 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,26544171 0,28948124 ! learning GO:0007612 67 37 0,000 0,26544171 0,28934405 ! ion transmembrane transport GO:0034220 56 37 0,000 0,26544171 0,28920698 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,26544171 0,28907005 ! regulation of protein secretion GO:0050708 51 37 0,000 0,26544171 0,28893324 ! amino acid activation GO:0043038 52 37 0,000 0,26544171 0,28879657 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,26544171 0,28866002 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,27154724 0,29516005 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,27154724 0,29502062 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,27154724 0,29488133 ! phagocytosis GO:0006909 60 38 0,000 0,27154724 0,29474217 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,27760237 0,30117238 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,27760237 0,30103039 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,27760237 0,30088853 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,27760237 0,3007468 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,27760237 0,3006052 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,27760237 0,30046374 ! male sex differentiation GO:0046661 53 39 0,000 0,27760237 0,30032241 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,27760237 0,30018122 ! JNK cascade GO:0007254 54 39 0,000 0,27760237 0,30004016 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,28360751 0,3063867 ! response to calcium ion GO:0051592 58 40 0,000 0,28360751 0,30624285 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,28360751 0,30609914 ! regulation of tube size GO:0035150 60 40 0,000 0,28360751 0,30595557 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,28360751 0,30581213 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,28360751 0,30566883 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,28360751 0,30552566 ! B cell differentiation GO:0030183 62 40 0,000 0,28360751 0,30538262 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,28360751 0,30523972 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,28360751 0,30509695 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,28956307 0,31135814 ! striated muscle contraction GO:0006941 62 41 0,000 0,28956307 0,31121265 ! biopolymer methylation GO:0043414 62 41 0,000 0,28956307 0,31106729 ! mitochondrial transport GO:0006839 60 42 0,000 0,29546946 0,31726413 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,29546946 0,31711608 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,29546946 0,31696817 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,29546946 0,3168204 ! excretion GO:0007588 63 42 0,000 0,29546946 0,31667277 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,29546946 0,31652528 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,29546946 0,31637792 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,29546946 0,3162307 ! neuromuscular process GO:0050905 79 43 0,000 0,30132709 0,32234991 ! tRNA processing GO:0008033 49 43 0,000 0,30132709 0,32220005 ! vesicle organization GO:0016050 79 43 0,000 0,30132709 0,32205032 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,30132709 0,32190074 ! methylation GO:0032259 64 43 0,000 0,30132709 0,3217513 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,30713634 0,32780213 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,30713634 0,32765008 ! regulation of ion transport GO:0043269 57 44 0,000 0,30713634 0,32749818 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,30713634 0,32734642 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,30713634 0,3271948 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,30713634 0,32704332 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,30713634 0,32689199 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,30713634 0,32674079 ! RNA catabolic process GO:0006401 64 45 0,000 0,31289762 0,33271592 ! positive regulation of defense response GO:0031349 59 45 0,000 0,31289762 0,33256217 ! regulation of translational initiation GO:0006446 64 45 0,000 0,31289762 0,33240856 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,31289762 0,33225509 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,31861132 0,33816615 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,31861132 0,33801017 ! cell redox homeostasis GO:0045454 63 46 0,000 0,31861132 0,33785433 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,31861132 0,33769864 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,32427784 0,34354631 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,32427784 0,34338814 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,32427784 0,34323011 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,32427784 0,34307223 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,32427784 0,3429145 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,32427784 0,34275691 ! chloride transport GO:0006821 67 48 0,000 0,32989755 0,34853669 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,32989755 0,34837666 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,32989755 0,34821678 ! gastrulation GO:0007369 73 48 0,000 0,32989755 0,34805705 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,32989755 0,34789747 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,32989755 0,34773803 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,32989755 0,34757873 ! regulation of endocytosis GO:0030100 63 48 0,000 0,32989755 0,34741958 ! nuclear export GO:0051168 69 48 0,000 0,32989755 0,34726058 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,32989755 0,34710173 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,33547085 0,35280428 ! sensory perception of smell GO:0007608 61 49 0,000 0,33547085 0,35264303 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,33547085 0,35248193 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,33547085 0,35232098 ! RNA elongation GO:0006354 62 49 0,000 0,33547085 0,35216018 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,33547085 0,35199952 ! regulation of actin filament length GO:0030832 72 50 0,000 0,34099811 0,35763596 ! membrane fusion GO:0006944 80 50 0,000 0,34099811 0,35747295 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,34099811 0,35731009 ! proton transport GO:0015992 75 50 0,000 0,34099811 0,35714738 ! positive regulation of secretion GO:0051047 71 51 0,000 0,34647971 0,36272341 ! hydrogen transport GO:0006818 77 51 0,000 0,34647971 0,36255839 ! adult behavior GO:0030534 80 51 0,000 0,34647971 0,36239351 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,34647971 0,36222879 ! transition metal ion transport GO:0000041 74 52 0,000 0,35191603 0,36774505 ! regulation of cellular component size GO:0032535 74 52 0,000 0,35191603 0,36757805 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,35191603 0,3674112 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,35730743 0,37287073 ! kidney development GO:0001822 90 53 0,000 0,35730743 0,37270163 ! single fertilization GO:0007338 59 53 0,000 0,35730743 0,37253268 ! amino acid transport GO:0006865 84 54 0,000 0,36265429 0,37793605 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,36265429 0,37776489 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,36265429 0,37759388 ! mesoderm development GO:0007498 76 55 0,000 0,36795697 0,38294165 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,36795697 0,38276845 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,36795697 0,38259541 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,37843125 0,39330857 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,37843125 0,39313093 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,37843125 0,39295344 ! camera-type eye development GO:0043010 88 57 0,000 0,37843125 0,39277611 ! secondary metabolic process GO:0019748 84 57 0,000 0,37843125 0,39259895 ! gonad development GO:0008406 79 57 0,000 0,37843125 0,39242194 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,38360356 0,39760621 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,38360356 0,39742711 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,38873312 0,40256018 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,38873312 0,40237901 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,39382028 0,40746138 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,39382028 0,40727817 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,39382028 0,40709512 ! fertilization GO:0009566 68 60 0,000 0,39382028 0,40691224 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,3988654 0,41194002 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,3988654 0,41175513 ! amine catabolic process GO:0009310 90 62 0,000 0,40386882 0,41673319 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,40386882 0,41654631 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,40386882 0,41635961 ! appendage morphogenesis GO:0035107 93 64 0,000 0,41375191 0,42635726 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,41375191 0,42616632 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,41375191 0,42597556 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,41375191 0,42578496 ! appendage development GO:0048736 94 65 0,000 0,41863226 0,43061458 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,41863226 0,43042208 ! defense response to bacterium GO:0042742 73 65 0,000 0,41863226 0,43022976 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,42347227 0,43500947 ! antigen processing and presentation GO:0019882 96 66 0,000 0,42347227 0,43481527 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,42347227 0,43462124 ! acute inflammatory response GO:0002526 92 68 0,000 0,43303254 0,44423499 ! learning or memory GO:0007611 123 68 0,000 0,43303254 0,44403694 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,43303254 0,44383906 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,43303254 0,44364136 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,43303254 0,44344383 ! rhythmic process GO:0048511 105 68 0,000 0,43303254 0,44324648 ! inorganic anion transport GO:0015698 93 68 0,000 0,43303254 0,44304931 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,43775347 0,4476803 ! response to metal ion GO:0010038 103 70 0,000 0,44243536 0,45226726 ! humoral immune response GO:0006959 86 70 0,000 0,44243536 0,45206634 ! amine transport GO:0015837 101 70 0,000 0,44243536 0,4518656 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,44243536 0,45166504 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,44707853 0,45620258 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,44707853 0,45600028 ! regulation of blood pressure GO:0008217 107 73 0,000 0,45624998 0,46514847 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,45624998 0,46494238 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,45624998 0,46473647 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,46077889 0,46914185 ! digestion GO:0007586 97 74 0,000 0,46077889 0,46893427 ! blood coagulation GO:0007596 116 75 0,000 0,46527033 0,47329578 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,46527033 0,47308655 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,46527033 0,47287749 ! tRNA metabolic process GO:0006399 95 76 0,000 0,46972462 0,47719374 ! response to unfolded protein GO:0006986 99 76 0,000 0,46972462 0,47698306 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,47414206 0,48125628 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,47852295 0,48548866 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,47852295 0,4852746 ! cellular respiration GO:0045333 107 79 0,000 0,48286759 0,48946473 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,48286759 0,4892491 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,48286759 0,48903367 ! chromatin assembly GO:0031497 102 80 0,000 0,48717629 0,49318022 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,48717629 0,49296325 ! hemostasis GO:0007599 125 81 0,000 0,49144933 0,49706836 ! mRNA transport GO:0051028 121 81 0,000 0,49144933 0,49684987 ! response to protein stimulus GO:0051789 111 81 0,000 0,49144933 0,49663157 ! vitamin metabolic process GO:0006766 103 81 0,000 0,49144933 0,49641346 ! regulation of defense response GO:0031347 117 84 0,000 0,50405744 0,50892542 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,50405744 0,50870211 ! nucleosome organization GO:0034728 114 87 0,000 0,51635507 0,5208845 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,51635507 0,52065615 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,51635507 0,52042799 ! female pregnancy GO:0007565 130 87 0,000 0,51635507 0,52020003 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,51635507 0,51997227 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,52038661 0,52380271 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,52038661 0,52357358 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,52038661 0,52334464 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,52438476 0,52713503 ! RNA localization GO:0006403 135 91 0,000 0,53228205 0,53483998 ! ATP metabolic process GO:0046034 137 91 0,000 0,53228205 0,53460642 ! cell fate commitment GO:0045165 141 92 0,000 0,53618171 0,53828806 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,54004909 0,54193407 ! electron transport chain GO:0022900 123 94 0,000 0,54388444 0,54554479 ! carboxylic acid transport GO:0046942 147 95 0,000 0,54768802 0,54912051 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,55146011 0,55266154 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,55146011 0,55242084 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,55520095 0,55592607 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,56623858 0,56673139 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,56623858 0,56648488 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,56623858 0,56623858