pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6780-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of apoptosis by intracellular signals GO:0008629 67 40 7,000 3,839E-12 8,829E-09 ! male meiosis GO:0007140 7 6 3,000 3,942E-09 4,533E-06 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 3,000 9,169E-09 7,03E-06 GO:0016446|somatic hypermutation of immunoglobulin genes, ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 3,000 9,169E-09 5,272E-06 ! response to UV GO:0009411 75 46 5,000 3,245E-08 1,493E-05 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 4,000 3,268E-08 1,253E-05 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 3,000 3,28E-08 1,078E-05 ! mismatch repair GO:0006298 34 29 4,000 1,132E-07 3,253E-05 ! negative regulation of DNA metabolic process GO:0051053 48 32 4,000 1,9E-07 4,857E-05 ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 3,000 4,636E-07 1,066E-04 ! somatic diversification of immunoglobulins GO:0016445 29 19 3,000 9,782E-07 2,045E-04 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 1,106E-06 2,12E-04 ! regulation of helicase activity GO:0051095 11 6 2,000 1,328E-06 2,349E-04 ! negative regulation of DNA recombination GO:0045910 9 6 2,000 1,328E-06 2,182E-04 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 1,335E-06 2,048E-04 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 3,000 1,501E-06 2,158E-04 GO:0016444|somatic cell DNA recombination, ! immunoglobulin production GO:0002377 33 21 3,000 1,501E-06 2,031E-04 GO:0002440|production of molecular mediator of immune response, ! DNA recombination GO:0006310 146 92 5,000 2,129E-06 2,72E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 2,207E-06 2,672E-04 ! somatic diversification of immune receptors GO:0002200 35 23 3,000 2,207E-06 2,538E-04 ! response to light stimulus GO:0009416 153 96 5,000 2,732E-06 2,992E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 3,133E-06 3,276E-04 GO:0045936|negative regulation of phosphate metabolic process, ! DNA damage response, signal transduction GO:0042770 96 56 4,000 3,339E-06 3,339E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 3,648E-06 3,496E-04 ! induction of positive chemotaxis GO:0050930 14 8 2,000 3,696E-06 3,4E-04 ! multicellular organism growth GO:0035264 14 8 2,000 3,696E-06 3,27E-04 ! negative regulation of kinase activity GO:0033673 100 58 4,000 3,98E-06 3,39E-04 ! meiosis GO:0007126 96 61 4,000 5,118E-06 4,204E-04 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of transferase activity GO:0051348 105 61 4,000 5,118E-06 4,059E-04 ! meiotic cell cycle GO:0051321 97 62 4,000 5,549E-06 4,254E-04 ! response to X-ray GO:0010165 16 10 2,000 7,873E-06 5,842E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 7,873E-06 5,659E-04 ! meiosis I GO:0007127 52 32 3,000 8,715E-06 6,074E-04 ! regulation of catabolic process GO:0009894 106 70 4,000 1,012E-05 6,844E-04 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 1,079E-05 7,093E-04 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 1,079E-05 6,896E-04 ! actin cytoskeleton reorganization GO:0031532 21 11 2,000 1,079E-05 6,71E-04 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 2,000 1,079E-05 6,533E-04 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! negative regulation of glucose import GO:0046325 14 11 2,000 1,079E-05 6,366E-04 GO:0010829|negative regulation of glucose transport, ! negative regulation of transport GO:0051051 116 73 4,000 1,244E-05 7,15E-04 ! immunoglobulin production during immune response GO:0002381 20 12 2,000 1,435E-05 8,05E-04 ! response to gamma radiation GO:0010332 20 12 2,000 1,435E-05 7,858E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,86E-05 9,948E-04 ! double-strand break repair GO:0006302 67 40 3,000 2,161E-05 1,129E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 2,941E-05 1,503E-03 ! induction of apoptosis by extracellular signals GO:0008624 74 44 3,000 3,17E-05 1,585E-03 ! regulation of inflammatory response GO:0050727 60 44 3,000 3,17E-05 1,551E-03 ! oogenesis GO:0048477 23 16 2,000 3,61E-05 1,73E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 3,61E-05 1,694E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 4,37E-05 2,01E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 4,37E-05 1,971E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 4,487E-05 1,985E-03 ! regulation of glucose import GO:0046324 21 18 2,000 5,229E-05 2,269E-03 GO:0010827|regulation of glucose transport, ! regulation of protein catabolic process GO:0042176 77 51 3,000 5,709E-05 2,432E-03 ! aging GO:0007568 79 52 3,000 6,166E-05 2,578E-03 ! reciprocal meiotic recombination GO:0007131 31 19 2,000 6,191E-05 2,543E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 7,262E-05 2,93E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 7,262E-05 2,88E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 7,262E-05 2,831E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 8,262E-05 3,167E-03 ! regulation of chemotaxis GO:0050920 36 21 2,000 8,447E-05 3,185E-03 ! regulation of DNA recombination GO:0000018 40 21 2,000 8,447E-05 3,133E-03 ! cell aging GO:0007569 32 21 2,000 8,447E-05 3,084E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 8,447E-05 3,036E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 8,447E-05 2,989E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 9,752E-05 3,398E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 9,752E-05 3,348E-03 ! regulation of behavior GO:0050795 38 22 2,000 9,752E-05 3,298E-03 ! protein tetramerization GO:0051262 39 22 2,000 9,752E-05 3,251E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,118E-04 3,674E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 1,118E-04 3,622E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 1,274E-04 4,07E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,311E-04 4,131E-03 ! B cell activation GO:0042113 104 65 3,000 1,481E-04 4,603E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,627E-04 4,99E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,627E-04 4,924E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,659E-04 4,957E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,659E-04 4,893E-03 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 1,000 1,659E-04 4,831E-03 ! peptidyl-histidine phosphorylation GO:0018106 7 5 1,000 1,659E-04 4,771E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 1,659E-04 4,712E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 1,659E-04 4,654E-03 ! centrosome duplication GO:0051298 5 5 1,000 1,659E-04 4,598E-03 ! response to UV-C GO:0010225 6 5 1,000 1,659E-04 4,544E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,659E-04 4,49E-03 ! glial cell migration GO:0008347 10 5 1,000 1,659E-04 4,438E-03 ! determination of adult lifespan GO:0008340 8 5 1,000 1,659E-04 4,387E-03 ! spindle assembly GO:0051225 5 5 1,000 1,659E-04 4,337E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 1,825E-04 4,716E-03 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,825E-04 4,664E-03 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 1,975E-04 4,991E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 2,038E-04 5,095E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 2,038E-04 5,04E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 2,202E-04 5,388E-03 GO:0045937|positive regulation of phosphate metabolic process, ! cytokinesis during cell cycle GO:0033205 9 6 1,000 2,482E-04 6,01E-03 ! prostate gland development GO:0030850 9 6 1,000 2,482E-04 5,948E-03 ! meiotic prophase I GO:0007128 9 6 1,000 2,482E-04 5,886E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 2,482E-04 5,826E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,482E-04 5,767E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 2,482E-04 5,71E-03 ! ER overload response GO:0006983 7 6 1,000 2,482E-04 5,653E-03 ! male sex determination GO:0030238 9 6 1,000 2,482E-04 5,598E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 2,482E-04 5,543E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of chromosome localization GO:0051303 9 6 1,000 2,482E-04 5,49E-03 GO:0050000|chromosome localization, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 2,482E-04 5,438E-03 ! peptidyl-histidine modification GO:0018202 9 6 1,000 2,482E-04 5,386E-03 ! axonal fasciculation GO:0007413 9 6 1,000 2,482E-04 5,336E-03 ! blastocyst growth GO:0001832 15 6 1,000 2,482E-04 5,287E-03 ! leukocyte chemotaxis GO:0030595 43 31 2,000 2,772E-04 5,848E-03 GO:0060326|cell chemotaxis, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,466E-04 7,247E-03 ! synaptonemal complex assembly GO:0007130 10 7 1,000 3,466E-04 7,182E-03 GO:0070193|synaptonemal complex organization, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 3,466E-04 7,118E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 3,466E-04 7,055E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 3,466E-04 6,993E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 3,466E-04 6,932E-03 ! multicellular organismal aging GO:0010259 11 7 1,000 3,466E-04 6,873E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 3,466E-04 6,814E-03 ! response to tumor cell GO:0002347 12 7 1,000 3,466E-04 6,756E-03 ! female gamete generation GO:0007292 43 34 2,000 3,657E-04 7,069E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 3,657E-04 7,01E-03 ! regulation of defense response GO:0031347 117 84 3,000 3,979E-04 7,564E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 3,988E-04 7,519E-03 ! cell cycle arrest GO:0007050 150 86 3,000 4,353E-04 8,139E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 4,609E-04 8,549E-03 ! axon extension GO:0048675 11 8 1,000 4,609E-04 8,481E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 4,609E-04 8,414E-03 ! endothelial cell differentiation GO:0045446 14 8 1,000 4,609E-04 8,347E-03 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 1,000 4,609E-04 8,282E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 4,609E-04 8,218E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 4,609E-04 8,155E-03 ! prophase GO:0051324 11 8 1,000 4,609E-04 8,093E-03 ! branched chain family amino acid catabolic process GO:0009083 11 8 1,000 4,609E-04 8,031E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 4,609E-04 7,971E-03 ! mitochondrion localization GO:0051646 12 8 1,000 4,609E-04 7,911E-03 ! reproductive developmental process GO:0003006 127 89 3,000 4,958E-04 8,448E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 5,504E-04 9,308E-03 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 5,856E-04 9,832E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 5,91E-04 9,851E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 5,91E-04 9,78E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 5,91E-04 9,71E-03 ! receptor clustering GO:0043113 15 9 1,000 5,91E-04 9,641E-03 ! oocyte differentiation GO:0009994 12 9 1,000 5,91E-04 9,573E-03 GO:0048599|oocyte development, ! localization within membrane GO:0051668 15 9 1,000 5,91E-04 9,506E-03 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 5,91E-04 9,44E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 5,932E-04 9,41E-03 ! regulation of response to external stimulus GO:0032101 139 96 3,000 6,602E-04 0,01039983 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 6,853E-04 0,01072183 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 7,345E-04 0,0114144 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 7,345E-04 0,01133779 ! leukocyte migration GO:0050900 60 43 2,000 7,345E-04 0,01126221 ! response to insulin stimulus GO:0032868 63 43 2,000 7,345E-04 0,01118762 ! synapsis GO:0007129 13 10 1,000 7,368E-04 0,01114941 GO:0070192|chromosome organization involved in meiosis, ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 7,368E-04 0,01107654 ! negative regulation of ossification GO:0030279 19 10 1,000 7,368E-04 0,01100461 ! regulation of B cell proliferation GO:0030888 15 10 1,000 7,368E-04 0,01093361 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 7,368E-04 0,01086352 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 7,368E-04 0,01079433 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 7,368E-04 0,01072601 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 7,368E-04 0,01065855 ! positive regulation of cell cycle GO:0045787 77 45 2,000 8,396E-04 0,0120689 ! positive regulation of defense response GO:0031349 59 45 2,000 8,396E-04 0,01199394 ! virus-host interaction GO:0019048 17 11 1,000 8,982E-04 0,01275182 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 8,982E-04 0,01267359 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 8,982E-04 0,01259631 GO:0000725|recombinational repair, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 8,982E-04 0,01251997 ! regulation of mRNA processing GO:0050684 18 11 1,000 8,982E-04 0,01244455 ! regulation of intracellular pH GO:0051453 17 11 1,000 8,982E-04 0,01237003 ! regulation of phagocytosis GO:0050764 14 11 1,000 8,982E-04 0,0122964 ! response to estrogen stimulus GO:0043627 74 47 2,000 9,538E-04 0,01298007 ! regulation of muscle contraction GO:0006937 69 48 2,000 1,014E-03 0,0137235 ! immunoglobulin mediated immune response GO:0016064 66 48 2,000 1,014E-03 0,01364324 GO:0019724|B cell mediated immunity, ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,075E-03 0,01437415 ! non-recombinational repair GO:0000726 19 12 1,000 1,075E-03 0,01429106 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,075E-03 0,01420893 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,075E-03 0,01412773 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,075E-03 0,01404746 ! regulation of intracellular transport GO:0032386 78 49 2,000 1,077E-03 0,0139991 ! cartilage development GO:0051216 70 49 2,000 1,077E-03 0,01392045 ! lipid modification GO:0030258 73 50 2,000 1,143E-03 0,01468297 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,211E-03 0,01546839 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,211E-03 0,01538293 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,267E-03 0,01601151 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,267E-03 0,01592401 ! regulation of cellular pH GO:0030641 20 13 1,000 1,267E-03 0,01583747 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,267E-03 0,01575186 ! nucleotide-excision repair GO:0006289 64 52 2,000 1,281E-03 0,01583922 ! regulation of S phase GO:0033261 18 14 1,000 1,474E-03 0,01813225 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,474E-03 0,0180358 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 1,474E-03 0,01794037 ! cellular response to starvation GO:0009267 21 14 1,000 1,474E-03 0,01784595 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,474E-03 0,01775251 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,474E-03 0,01766005 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 1,000 1,474E-03 0,01756855 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of ATPase activity GO:0043462 18 14 1,000 1,474E-03 0,01747799 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,474E-03 0,01738836 ! positive regulation of cell motion GO:0051272 99 56 2,000 1,588E-03 0,01863295 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 1,671E-03 0,01951082 ! lipid phosphorylation GO:0046834 23 15 1,000 1,697E-03 0,01970693 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 1,697E-03 0,0196079 ! centrosome cycle GO:0007098 16 15 1,000 1,697E-03 0,01950986 ! neuron recognition GO:0008038 22 15 1,000 1,697E-03 0,0194128 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,697E-03 0,0193167 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,697E-03 0,01922154 ! lung development GO:0030324 94 59 2,000 1,846E-03 0,02081074 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,934E-03 0,0216953 ! endothelial cell migration GO:0043542 22 16 1,000 1,934E-03 0,02158999 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,934E-03 0,02148569 ! cellular response to unfolded protein GO:0034620 19 16 1,000 1,934E-03 0,02138239 GO:0030968|endoplasmic reticulum unfolded protein response, ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 1,934E-03 0,02128008 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,934E-03 0,02117875 ! regulation of heart contraction GO:0008016 91 60 2,000 1,937E-03 0,02111714 ! negative regulation of cell growth GO:0030308 106 62 2,000 2,129E-03 0,02309251 ! respiratory tube development GO:0030323 99 62 2,000 2,129E-03 0,0229841 ! lymphocyte mediated immunity GO:0002449 88 62 2,000 2,129E-03 0,02287669 ! organelle localization GO:0051640 96 62 2,000 2,129E-03 0,02277029 ! signal complex assembly GO:0007172 29 17 1,000 2,186E-03 0,0232738 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 2,186E-03 0,02316655 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 2,186E-03 0,02306028 ! sensory perception of pain GO:0019233 23 17 1,000 2,186E-03 0,02295498 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 2,186E-03 0,02285064 ! regulation of transcription factor activity GO:0051090 97 63 2,000 2,228E-03 0,02319147 GO:0090046|regulation of transcription regulator activity, ! negative regulation of cell size GO:0045792 108 64 2,000 2,331E-03 0,02415139 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 2,331E-03 0,02404309 ! respiratory system development GO:0060541 100 64 2,000 2,331E-03 0,02393576 ! adaptive immune response GO:0002250 94 64 2,000 2,331E-03 0,02382937 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 2,000 2,437E-03 0,02479894 ! protein oligomerization GO:0051259 100 65 2,000 2,437E-03 0,02468969 ! positive regulation of DNA replication GO:0045740 29 18 1,000 2,452E-03 0,02473904 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 2,452E-03 0,02463101 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,452E-03 0,02452392 ! prostaglandin metabolic process GO:0006693 31 18 1,000 2,452E-03 0,02441775 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 1,000 2,452E-03 0,0243125 ! cellular response to nutrient levels GO:0031669 27 18 1,000 2,452E-03 0,02420816 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 2,452E-03 0,0241047 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 2,734E-03 0,02675463 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,734E-03 0,02664126 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,734E-03 0,02652885 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 2,734E-03 0,02641739 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 2,734E-03 0,02630685 ! response to starvation GO:0042594 30 19 1,000 2,734E-03 0,02619724 ! sex determination GO:0007530 29 19 1,000 2,734E-03 0,02608854 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 2,734E-03 0,02598074 ! protein stabilization GO:0050821 26 19 1,000 2,734E-03 0,02587382 ! fatty acid beta-oxidation GO:0006635 31 20 1,000 3,029E-03 0,02855481 ! positive regulation of B cell activation GO:0050871 31 20 1,000 3,029E-03 0,02843826 ! leukocyte mediated immunity GO:0002443 99 71 2,000 3,133E-03 0,02929074 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 3,339E-03 0,03109446 ! protein amino acid acylation GO:0043543 37 21 1,000 3,339E-03 0,03096908 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 3,339E-03 0,03084471 ! cholesterol biosynthetic process GO:0006695 29 21 1,000 3,339E-03 0,03072133 ! regulation of bone mineralization GO:0030500 29 21 1,000 3,339E-03 0,03059893 ! mitochondrion organization GO:0007005 104 73 2,000 3,389E-03 0,03093326 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 3,389E-03 0,03081099 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 3,522E-03 0,03189278 ! negative regulation of growth GO:0045926 123 75 2,000 3,658E-03 0,0329945 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 3,663E-03 0,03291381 ! microtubule organizing center organization GO:0031023 28 22 1,000 3,663E-03 0,03278574 GO:0051297|centrosome organization, ! blastocyst development GO:0001824 37 22 1,000 3,663E-03 0,03265867 ! tRNA metabolic process GO:0006399 95 76 2,000 3,797E-03 0,03372094 ! regulation of protein transport GO:0051223 114 76 2,000 3,797E-03 0,03359124 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 2,000 3,94E-03 0,03471723 ! gland development GO:0048732 148 77 2,000 3,94E-03 0,03458472 ! sex differentiation GO:0007548 105 77 2,000 3,94E-03 0,03445322 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 4,002E-03 0,03486331 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 4,002E-03 0,03473175 ! interaction with host GO:0051701 37 23 1,000 4,002E-03 0,03460118 ! regulation of biomineral formation GO:0070167 31 23 1,000 4,002E-03 0,03447159 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 1,000 4,002E-03 0,03434296 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! negative regulation of catabolic process GO:0009895 34 23 1,000 4,002E-03 0,03421529 ! positive regulation of protein modification process GO:0031401 107 78 2,000 4,085E-03 0,03480027 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 4,354E-03 0,036952 ! mitochondrial membrane organization GO:0007006 39 24 1,000 4,354E-03 0,03681615 ! receptor metabolic process GO:0043112 37 24 1,000 4,354E-03 0,03668129 ! negative regulation of cell development GO:0010721 56 24 1,000 4,354E-03 0,03654742 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 4,354E-03 0,03641452 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 4,354E-03 0,03628258 ! ossification GO:0001503 134 82 2,000 4,7E-03 0,03902728 GO:0060348|bone development, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 4,72E-03 0,03905001 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 4,72E-03 0,03891005 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 5,028E-03 0,04129805 ! regulation of pH GO:0006885 36 26 1,000 5,1E-03 0,04174156 ! post-embryonic development GO:0009791 42 26 1,000 5,1E-03 0,04159354 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 5,196E-03 0,04223137 ! regulation of protein localization GO:0032880 132 85 2,000 5,196E-03 0,04208266 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 5,368E-03 0,04332376 ! acute-phase response GO:0006953 42 27 1,000 5,493E-03 0,04417534 ! respiratory gaseous exchange GO:0007585 47 27 1,000 5,493E-03 0,04402142 ! lipid oxidation GO:0034440 38 27 1,000 5,493E-03 0,04386857 GO:0019395|fatty acid oxidation, ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 5,493E-03 0,04371677 GO:0043433|negative regulation of transcription factor activity, ! interphase GO:0051325 159 88 2,000 5,723E-03 0,04538744 ! carboxylic acid catabolic process GO:0046395 122 88 2,000 5,723E-03 0,04523146 GO:0016054|organic acid catabolic process, ! positive regulation of endocytosis GO:0045807 33 28 1,000 5,9E-03 0,04647243 ! response to organic cyclic substance GO:0014070 47 28 1,000 5,9E-03 0,04631382 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 1,000 5,9E-03 0,04615629 ! sterol biosynthetic process GO:0016126 40 28 1,000 5,9E-03 0,04599983 ! regulation of B cell activation GO:0050864 42 28 1,000 5,9E-03 0,04584442 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 6,32E-03 0,0489445 ! tissue homeostasis GO:0001894 42 29 1,000 6,32E-03 0,04878026 GO:0048871|multicellular organismal homeostasis, ! spindle organization GO:0007051 37 30 1,000 6,754E-03 0,05195181 ! fatty acid catabolic process GO:0009062 43 30 1,000 6,754E-03 0,05177863 ! regulation of binding GO:0051098 151 95 2,000 7,072E-03 0,05403984 ! DNA damage checkpoint GO:0000077 53 31 1,000 7,2E-03 0,05483744 ! mammary gland development GO:0030879 57 31 1,000 7,2E-03 0,05465646 ! maintenance of protein location in cell GO:0032507 60 31 1,000 7,2E-03 0,05447667 ! segmentation GO:0035282 41 31 1,000 7,2E-03 0,05429806 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 7,2E-03 0,05412062 ! in utero embryonic development GO:0001701 147 96 2,000 7,279E-03 0,05453329 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 7,489E-03 0,05592742 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 7,66E-03 0,05701687 ! peripheral nervous system development GO:0007422 53 32 1,000 7,66E-03 0,05683294 ! regulation of protein stability GO:0031647 48 32 1,000 7,66E-03 0,0566502 ! calcium-mediated signaling GO:0019722 50 32 1,000 7,66E-03 0,05646863 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 7,66E-03 0,05628822 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 7,921E-03 0,05801976 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 8,133E-03 0,05938173 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 8,133E-03 0,05919381 ! carbohydrate homeostasis GO:0033500 39 33 1,000 8,133E-03 0,05900708 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 8,133E-03 0,05882152 ! negative regulation of DNA binding GO:0043392 54 33 1,000 8,133E-03 0,05863713 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 8,133E-03 0,05845389 ! cytokinesis GO:0000910 52 33 1,000 8,133E-03 0,05827179 ! mRNA catabolic process GO:0006402 48 34 1,000 8,618E-03 0,06155823 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 8,618E-03 0,06136764 ! DNA integrity checkpoint GO:0031570 57 34 1,000 8,618E-03 0,06117824 ! neuron migration GO:0001764 46 34 1,000 8,618E-03 0,06099 ! maintenance of protein location GO:0045185 65 35 1,000 9,116E-03 0,0643174 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 9,116E-03 0,06412071 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 9,627E-03 0,06750659 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 9,627E-03 0,0673014 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 9,627E-03 0,06709746 GO:0046660|female sex differentiation, ! amino acid activation GO:0043038 52 37 1,000 0,01015025 0,07053041 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! gliogenesis GO:0042063 71 38 1,000 0,01068584 0,07402841 ! maintenance of location in cell GO:0051651 69 38 1,000 0,01068584 0,07380611 ! JNK cascade GO:0007254 54 39 1,000 0,0112337 0,07735784 ! developmental growth GO:0048589 62 39 1,000 0,0112337 0,07712692 ! cell growth GO:0016049 61 39 1,000 0,0112337 0,07689738 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,01179373 0,08049132 ! T cell differentiation GO:0030217 65 40 1,000 0,01179373 0,08025318 ! B cell differentiation GO:0030183 62 40 1,000 0,01179373 0,08001644 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01179373 0,0797811 ! endosome transport GO:0016197 71 41 1,000 0,01236581 0,08340573 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01236581 0,08316186 ! mitochondrial transport GO:0006839 60 42 1,000 0,01294983 0,08683562 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,01294983 0,08658319 ! positive regulation of binding GO:0051099 59 43 1,000 0,0135457 0,09030469 ! activation of caspase activity GO:0006919 65 43 1,000 0,0135457 0,0900437 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,0135457 0,0897842 ! tRNA processing GO:0008033 49 43 1,000 0,0135457 0,0895262 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01415331 0,09327398 ! RNA catabolic process GO:0006401 64 45 1,000 0,01477256 0,0970768 ! cell recognition GO:0008037 58 45 1,000 0,01477256 0,09680023 ! cell maturation GO:0048469 60 45 1,000 0,01477256 0,09652523 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,01540333 0,10036165 ! regulation of ossification GO:0030278 71 46 1,000 0,01540333 0,10007814 ! histone modification GO:0016570 68 46 1,000 0,01540333 0,09979623 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01604553 0,10366497 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01604553 0,10337459 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01604553 0,10308584 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01669906 0,10698565 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 0,01669906 0,10668847 ! regulation of endocytosis GO:0030100 63 48 1,000 0,01669906 0,10639293 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,01736382 0,11032261 ! germ cell development GO:0007281 68 49 1,000 0,01736382 0,11001869 ! maintenance of location GO:0051235 84 49 1,000 0,01736382 0,10971644 ! positive regulation of growth GO:0045927 67 50 1,000 0,0180397 0,11367482 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,0187266 0,11768083 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01942443 0,12173348 ! establishment of organelle localization GO:0051656 85 52 1,000 0,01942443 0,12140269 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,02013308 0,12549076 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,020426 0,12697245 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,020426 0,1266302 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,020426 0,1262898 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,020426 0,12595122 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,020426 0,12561445 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,020426 0,12527948 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,020426 0,12494629 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,020426 0,12461487 ! sleep GO:0030431 11 5 0,000 0,020426 0,1242852 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,020426 0,12395727 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,020426 0,12363107 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,020426 0,12330657 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,020426 0,12298378 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,020426 0,12266268 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,020426 0,12234324 ! tongue development GO:0043586 6 5 0,000 0,020426 0,12202547 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,020426 0,12170934 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,020426 0,12139484 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,020426 0,12108197 ! cobalt ion transport GO:0006824 9 5 0,000 0,020426 0,12077071 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,020426 0,12046104 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,020426 0,12015295 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,020426 0,11984644 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,020426 0,11954149 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,020426 0,11923808 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,020426 0,11893622 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,020426 0,11863587 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,020426 0,11833704 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,020426 0,11803971 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,020426 0,11774387 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,020426 0,11744951 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,020426 0,11715662 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,020426 0,11686519 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,020426 0,1165752 ! malate metabolic process GO:0006108 7 5 0,000 0,020426 0,11628665 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,020426 0,11599952 ! behavioral response to pain GO:0048266 7 5 0,000 0,020426 0,11571381 ! clathrin coat assembly GO:0048268 11 5 0,000 0,020426 0,1154295 ! phototransduction, visible light GO:0007603 6 5 0,000 0,020426 0,11514658 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,020426 0,11486505 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,020426 0,11458489 ! mating behavior GO:0007617 6 5 0,000 0,020426 0,11430609 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,020426 0,11402865 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,020426 0,11375255 ! rhythmic behavior GO:0007622 12 5 0,000 0,020426 0,11347779 ! copulation GO:0007620 7 5 0,000 0,020426 0,11320435 ! glial cell fate commitment GO:0021781 12 5 0,000 0,020426 0,11293222 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,020426 0,1126614 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,020426 0,11239188 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,020426 0,11212364 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,020426 0,11185668 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,020426 0,11159099 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,020426 0,11132655 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,020426 0,11106337 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,020426 0,11080143 ! response to protozoan GO:0001562 9 5 0,000 0,020426 0,11054072 ! lymph vessel development GO:0001945 7 5 0,000 0,020426 0,11028123 ! endochondral ossification GO:0001958 12 5 0,000 0,020426 0,11002296 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,020426 0,1097659 ! parathyroid gland development GO:0060017 8 5 0,000 0,020426 0,10951003 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,020426 0,10925536 ! anagen GO:0042640 6 5 0,000 0,020426 0,10900187 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,020426 0,10874955 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,020426 0,10849839 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,020426 0,1082484 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,020426 0,10799955 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,020426 0,10775185 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,020426 0,10750527 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,020426 0,10725983 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,020426 0,1070155 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,020426 0,10677228 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,020426 0,10653017 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,020426 0,10628915 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,020426 0,10604922 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,020426 0,10581037 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,020426 0,1055726 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,020426 0,10533589 ! ovulation GO:0030728 6 5 0,000 0,020426 0,10510023 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,020426 0,10486564 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,020426 0,10463208 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,020426 0,10439957 ! response to pH GO:0009268 9 5 0,000 0,020426 0,10416808 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,020426 0,10393762 ! proline biosynthetic process GO:0006561 6 5 0,000 0,020426 0,10370818 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,020426 0,10347975 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,020426 0,10325232 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,020426 0,10302589 ! polyol catabolic process GO:0046174 7 5 0,000 0,020426 0,10280045 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,020426 0,10257599 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,020426 0,10235252 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,020426 0,10213001 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,020426 0,10190847 ! nerve growth factor processing GO:0032455 7 5 0,000 0,020426 0,10168789 ! urea metabolic process GO:0019627 6 5 0,000 0,020426 0,10146826 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,020426 0,10124958 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,020426 0,10103184 ! neutrophil activation GO:0042119 5 5 0,000 0,020426 0,10081503 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,020426 0,10059915 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,020426 0,1003842 ! response to food GO:0032094 5 5 0,000 0,020426 0,10017016 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,020426 0,09995703 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,020426 0,09974481 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,020426 0,09953349 ! forebrain neuron development GO:0021884 7 5 0,000 0,020426 0,09932305 ! melanosome organization GO:0032438 7 5 0,000 0,020426 0,09911351 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,020426 0,09890485 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,020426 0,09869707 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,020426 0,09849016 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,020426 0,09828411 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,020426 0,09807892 ! nucleoside transport GO:0015858 6 5 0,000 0,020426 0,09787459 ! nucleoside salvage GO:0043174 7 5 0,000 0,020426 0,09767111 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,020426 0,09746848 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,020426 0,09726668 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,020426 0,09706571 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,020426 0,09686558 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,020426 0,09666627 ! depyrimidination GO:0045008 8 5 0,000 0,020426 0,09646777 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,020426 0,09627009 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,020426 0,09607322 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,020426 0,09587715 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,020426 0,09568188 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,020426 0,09548741 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,020426 0,09529372 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,020426 0,09510082 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,020426 0,0949087 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,020426 0,09471735 ! monocyte differentiation GO:0030224 8 5 0,000 0,020426 0,09452677 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,020426 0,09433696 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,020426 0,09414791 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,020426 0,09395961 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,020426 0,09377207 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,020426 0,09358527 ! regulation of dendrite development GO:0050773 12 5 0,000 0,020426 0,09339921 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,020426 0,0932139 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,020426 0,09302932 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,020426 0,09284546 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,020426 0,09266234 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,020426 0,09247993 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,020426 0,09229824 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,020426 0,09211726 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,020426 0,091937 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,020426 0,09175743 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,020426 0,09157857 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,020426 0,0914004 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,020426 0,09122292 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,020426 0,09104613 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,020426 0,09087003 ! neural tube patterning GO:0021532 6 5 0,000 0,020426 0,0906946 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,020426 0,09051986 ! histone demethylation GO:0016577 9 5 0,000 0,020426 0,09034578 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,020426 0,09017237 ! regulation of sterol transport GO:0032371 7 5 0,000 0,020426 0,08999963 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,020426 0,08982754 ! enteric nervous system development GO:0048484 8 5 0,000 0,020426 0,08965612 ! establishment of planar polarity GO:0001736 6 5 0,000 0,020426 0,08948534 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,020426 0,08931522 ! muscle cell proliferation GO:0033002 8 5 0,000 0,020426 0,08914574 ! transcription termination GO:0006353 8 5 0,000 0,020426 0,0889769 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,020426 0,08880871 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,020426 0,08864114 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,020426 0,08847421 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,020426 0,0883079 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,020426 0,08814222 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,020426 0,08797716 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,020426 0,08781272 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,020426 0,08764889 ! apical protein localization GO:0045176 6 5 0,000 0,020426 0,08748567 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,020426 0,08732306 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,020426 0,08716105 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,020426 0,08699964 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,020426 0,08683883 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,020426 0,08667861 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,020426 0,08651898 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,020426 0,08635994 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,020426 0,08620148 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,020426 0,0860436 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,020426 0,0858863 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,020426 0,08572957 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,020426 0,08557342 ! neural plate development GO:0001840 6 5 0,000 0,020426 0,08541783 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,020426 0,0852628 ! regulation of sensory perception GO:0051931 6 5 0,000 0,020426 0,08510834 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,020426 0,08495444 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,020426 0,08480109 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,020426 0,0846483 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,020426 0,08449605 ! sensory cilium assembly GO:0035058 6 5 0,000 0,020426 0,08434435 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,020426 0,0841932 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,020426 0,08404258 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,020426 0,08389251 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,020426 0,08374297 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,020426 0,08359396 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,020426 0,08344548 ! organ regeneration GO:0031100 7 5 0,000 0,020426 0,08329753 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,020426 0,0831501 ! carnitine metabolic process GO:0009437 5 5 0,000 0,020426 0,08300319 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,020426 0,0828568 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,020426 0,08271092 GO:0055081|anion homeostasis, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,02085246 0,08428939 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,02085246 0,08414152 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,02085246 0,08399416 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,02085246 0,08384732 ! chromosome segregation GO:0007059 83 57 1,000 0,02307399 0,09261811 ! developmental maturation GO:0021700 75 57 1,000 0,02307399 0,09245676 ! gonad development GO:0008406 79 57 1,000 0,02307399 0,09229596 ! viral reproductive process GO:0022415 87 58 1,000 0,02383531 0,09517571 ! tRNA transcription GO:0009304 11 6 0,000 0,02446155 0,09750706 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02446155 0,09733836 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02446155 0,09717025 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02446155 0,09700271 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02446155 0,09683575 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02446155 0,09666937 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02446155 0,09650356 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02446155 0,09633831 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02446155 0,09617363 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02446155 0,09600951 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02446155 0,09584595 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02446155 0,09568295 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02446155 0,0955205 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02446155 0,0953586 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02446155 0,09519725 GO:0046463|acylglycerol biosynthetic process, ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02446155 0,09503644 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02446155 0,09487618 ! neuron adhesion GO:0007158 9 6 0,000 0,02446155 0,09471645 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02446155 0,09455726 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02446155 0,09439861 ! signal peptide processing GO:0006465 8 6 0,000 0,02446155 0,09424049 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02446155 0,0940829 ! mRNA stabilization GO:0048255 15 6 0,000 0,02446155 0,09392583 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02446155 0,09376929 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02446155 0,09361327 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02446155 0,09345776 ! opsonization GO:0008228 8 6 0,000 0,02446155 0,09330277 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02446155 0,0931483 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02446155 0,09299433 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02446155 0,09284088 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02446155 0,09268793 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02446155 0,09253548 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02446155 0,09238353 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02446155 0,09223209 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02446155 0,09208113 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02446155 0,09193067 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02446155 0,09178071 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02446155 0,09163123 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02446155 0,09148223 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02446155 0,09133372 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02446155 0,09118569 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02446155 0,09103814 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02446155 0,09089107 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02446155 0,09074447 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02446155 0,09059835 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02446155 0,09045269 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02446155 0,0903075 ! thymic T cell selection GO:0045061 12 6 0,000 0,02446155 0,09016278 ! protein lipoylation GO:0009249 10 6 0,000 0,02446155 0,09001852 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02446155 0,08987472 ! pigment granule organization GO:0048753 11 6 0,000 0,02446155 0,08973138 ! drug transport GO:0015893 6 6 0,000 0,02446155 0,08958849 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02446155 0,08944606 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02446155 0,08930408 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02446155 0,08916256 ! histidine metabolic process GO:0006547 6 6 0,000 0,02446155 0,08902148 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02446155 0,08888084 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02446155 0,08874065 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02446155 0,0886009 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02446155 0,08846159 ! adenohypophysis development GO:0021984 10 6 0,000 0,02446155 0,08832272 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02446155 0,08818428 ! hyperosmotic response GO:0006972 8 6 0,000 0,02446155 0,08804628 ! microtubule nucleation GO:0007020 10 6 0,000 0,02446155 0,08790871 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02446155 0,08777156 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02446155 0,08763485 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02446155 0,08749856 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02446155 0,08736269 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02446155 0,08722724 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02446155 0,08709222 ! response to dietary excess GO:0002021 7 6 0,000 0,02446155 0,08695761 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02446155 0,08682341 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02446155 0,08668963 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02446155 0,08655627 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02446155 0,08642331 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02446155 0,08629076 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02446155 0,08615861 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02446155 0,08602687 ! neuron apoptosis GO:0051402 8 6 0,000 0,02446155 0,08589553 ! organic alcohol transport GO:0015850 9 6 0,000 0,02446155 0,08576459 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02446155 0,08563405 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02446155 0,08550391 ! carnitine transport GO:0015879 8 6 0,000 0,02446155 0,08537416 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02446155 0,08524481 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02446155 0,08511584 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02446155 0,08498727 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02446155 0,08485908 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02446155 0,08473128 ! parturition GO:0007567 12 6 0,000 0,02446155 0,08460387 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02446155 0,08447684 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02446155 0,08435018 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02446155 0,08422391 ! spindle checkpoint GO:0031577 14 6 0,000 0,02446155 0,08409802 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02446155 0,0839725 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02446155 0,08384735 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02446155 0,08372258 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02446155 0,08359818 ! macrophage differentiation GO:0030225 10 6 0,000 0,02446155 0,08347414 ! astrocyte development GO:0014002 14 6 0,000 0,02446155 0,08335048 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02446155 0,08322718 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02446155 0,08310424 ! interaction with symbiont GO:0051702 8 6 0,000 0,02446155 0,08298167 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02446155 0,08285946 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02446155 0,08273761 ! eating behavior GO:0042755 6 6 0,000 0,02446155 0,08261611 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02446155 0,08249497 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02446155 0,08237419 ! response to copper ion GO:0046688 9 6 0,000 0,02446155 0,08225376 ! DNA topological change GO:0006265 8 6 0,000 0,02446155 0,08213368 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02446155 0,08201395 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02446155 0,08189457 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02446155 0,08177554 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02446155 0,08165685 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02446155 0,08153851 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02446155 0,08142051 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02446155 0,08130285 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02446155 0,08118553 ! gas homeostasis GO:0033483 11 6 0,000 0,02446155 0,08106855 ! hair follicle maturation GO:0048820 7 6 0,000 0,02446155 0,0809519 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02446155 0,08083559 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02446155 0,08071962 ! Schwann cell development GO:0014044 14 6 0,000 0,02446155 0,08060397 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02446155 0,08048866 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02446155 0,08037368 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02446155 0,08025902 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02446155 0,08014469 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02446155 0,08003069 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02446155 0,07991701 ! histone ubiquitination GO:0016574 7 6 0,000 0,02446155 0,07980365 ! regulation of meiosis GO:0040020 10 6 0,000 0,02446155 0,07969061 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02446155 0,0795779 GO:0000085|G2 phase of mitotic cell cycle, ! regulation of cell division GO:0051302 8 6 0,000 0,02446155 0,0794655 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02446155 0,07935342 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02446155 0,07924165 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02446155 0,0791302 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02446155 0,07901906 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02446155 0,07890824 ! receptor internalization GO:0031623 9 6 0,000 0,02446155 0,07879772 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02446155 0,07868751 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02446155 0,07857762 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02446155 0,07846802 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02446155 0,07835874 ! protein deubiquitination GO:0016579 8 6 0,000 0,02446155 0,07824975 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02446155 0,07814107 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02446155 0,07803269 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02446155 0,07792462 ! midbrain development GO:0030901 6 6 0,000 0,02446155 0,07781684 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02446155 0,07770935 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02446155 0,07760217 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02446155 0,07749528 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02446155 0,07738868 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02446155 0,07728238 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02446155 0,07717637 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02446155 0,07707065 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02446155 0,07696522 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02446155 0,07686007 ! adult feeding behavior GO:0008343 6 6 0,000 0,02446155 0,07675522 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02446155 0,07665064 ! pigment granule transport GO:0051904 12 6 0,000 0,02446155 0,07654636 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02446155 0,07644235 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02446155 0,07633863 ! catecholamine transport GO:0051937 7 6 0,000 0,02446155 0,07623519 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02446155 0,07613203 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02446155 0,07602915 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02446155 0,07592655 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02446155 0,07582422 ! protein prenylation GO:0018342 10 6 0,000 0,02446155 0,07572217 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02446155 0,07562039 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02446155 0,07551889 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02446155 0,07541766 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02446155 0,0753167 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02446155 0,07521601 ! activation of MAPK activity GO:0000187 84 59 1,000 0,02460687 0,07556181 ! actin filament organization GO:0007015 95 59 1,000 0,02460687 0,07546106 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,02460687 0,07536058 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,02538858 0,07765124 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,02538858 0,07754812 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,02538858 0,07744527 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,02538858 0,07734269 ! urogenital system development GO:0001655 101 61 1,000 0,02618034 0,0796492 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,02618034 0,07954398 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,02618034 0,07943904 ! amine catabolic process GO:0009310 90 62 1,000 0,02698207 0,08176385 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,02698207 0,08165627 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,02779367 0,08400189 ! viral reproduction GO:0016032 92 63 1,000 0,02779367 0,08389165 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02779367 0,0837817 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02848071 0,08574035 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02848071 0,08562828 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02848071 0,08551649 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02848071 0,085405 ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02848071 0,08529379 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02848071 0,08518288 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02848071 0,08507225 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02848071 0,08496191 ! reproductive behavior GO:0019098 12 7 0,000 0,02848071 0,08485185 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02848071 0,08474208 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,02848071 0,0846326 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02848071 0,0845234 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02848071 0,08441447 ! oligopeptide transport GO:0006857 11 7 0,000 0,02848071 0,08430583 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02848071 0,08419747 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02848071 0,08408939 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02848071 0,08398158 ! RNA methylation GO:0001510 11 7 0,000 0,02848071 0,08387405 ! pericardium development GO:0060039 8 7 0,000 0,02848071 0,08376679 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02848071 0,08365981 ! fibril organization GO:0043206 13 7 0,000 0,02848071 0,0835531 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02848071 0,08344666 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02848071 0,0833405 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02848071 0,0832346 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02848071 0,08312897 ! lipoprotein transport GO:0042953 9 7 0,000 0,02848071 0,08302361 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02848071 0,08291852 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02848071 0,08281369 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02848071 0,08270913 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02848071 0,08260483 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02848071 0,08250079 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02848071 0,08239702 ! chemosensory behavior GO:0007635 9 7 0,000 0,02848071 0,08229351 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02848071 0,08219025 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02848071 0,08208726 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02848071 0,08198452 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02848071 0,08188204 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02848071 0,08177981 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02848071 0,08167784 ! reflex GO:0060004 12 7 0,000 0,02848071 0,08157613 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02848071 0,08147467 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02848071 0,08137345 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02848071 0,0812725 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02848071 0,08117179 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02848071 0,08107133 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02848071 0,08097111 ! spinal cord patterning GO:0021511 7 7 0,000 0,02848071 0,08087115 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02848071 0,08077143 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02848071 0,08067196 ! adrenal gland development GO:0030325 17 7 0,000 0,02848071 0,08057273 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02848071 0,08047375 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02848071 0,08037501 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02848071 0,08027651 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02848071 0,08017825 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02848071 0,08008023 ! endosome organization GO:0007032 10 7 0,000 0,02848071 0,07998246 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02848071 0,07988492 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02848071 0,07978761 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02848071 0,07969055 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02848071 0,07959372 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02848071 0,07949713 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02848071 0,07940077 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02848071 0,07930464 ! galactose metabolic process GO:0006012 10 7 0,000 0,02848071 0,07920874 ! vesicle fusion GO:0006906 15 7 0,000 0,02848071 0,07911308 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02848071 0,07901765 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02848071 0,07892245 ! organ growth GO:0035265 11 7 0,000 0,02848071 0,07882747 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02848071 0,07873273 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02848071 0,07863821 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02848071 0,07854392 ! retinol metabolic process GO:0042572 9 7 0,000 0,02848071 0,07844986 ! behavioral fear response GO:0001662 13 7 0,000 0,02848071 0,07835602 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02848071 0,0782624 ! rRNA modification GO:0000154 12 7 0,000 0,02848071 0,07816901 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02848071 0,07807584 ! response to UV-B GO:0010224 11 7 0,000 0,02848071 0,07798289 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02848071 0,07789017 ! intermediate filament organization GO:0045109 11 7 0,000 0,02848071 0,07779766 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02848071 0,07770538 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02848071 0,07761331 ! fibrinolysis GO:0042730 9 7 0,000 0,02848071 0,07752146 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02848071 0,07742982 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02848071 0,07733841 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02848071 0,07724721 ! response to tropane GO:0014073 13 7 0,000 0,02848071 0,07715622 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02848071 0,07706545 ! melanosome localization GO:0032400 10 7 0,000 0,02848071 0,07697489 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02848071 0,07688454 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02848071 0,07679441 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02848071 0,07670449 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02848071 0,07661477 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02848071 0,07652527 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02848071 0,07643598 ! mast cell activation GO:0045576 9 7 0,000 0,02848071 0,07634689 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02848071 0,07625801 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02848071 0,07616934 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02848071 0,07608087 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02848071 0,07599261 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02848071 0,07590456 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,02848071 0,0758167 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02848071 0,07572905 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02848071 0,07564161 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02848071 0,07555436 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02848071 0,07546732 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02848071 0,07538047 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02848071 0,07529383 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02848071 0,07520738 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02848071 0,07512114 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02848071 0,07503509 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02848071 0,07494923 ! diuresis GO:0030146 12 7 0,000 0,02848071 0,07486358 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02848071 0,07477812 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02848071 0,07469285 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02848071 0,07460778 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02848071 0,0745229 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02848071 0,07443822 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02848071 0,07435372 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02848071 0,07426942 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02848071 0,07418531 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02848071 0,07410139 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02848071 0,07401766 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02848071 0,07393412 ! lymph node development GO:0048535 9 7 0,000 0,02848071 0,07385077 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02848071 0,0737676 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02848071 0,07368462 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02848071 0,07360183 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02848071 0,07351923 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02848071 0,07343681 ! ATP catabolic process GO:0006200 10 7 0,000 0,02848071 0,07335457 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02848071 0,07327252 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02848071 0,07319065 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02848071 0,07310896 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02848071 0,07302746 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02848071 0,07294614 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02848071 0,072865 ! muscle adaptation GO:0043500 12 7 0,000 0,02848071 0,07278403 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02848071 0,07270325 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02848071 0,07262265 ! retina homeostasis GO:0001895 9 7 0,000 0,02848071 0,07254223 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02848071 0,07246198 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02848071 0,07238191 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02848071 0,07230202 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02848071 0,07222231 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02848071 0,07214277 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02848071 0,0720634 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02848071 0,07198421 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,02861504 0,07224434 ! regulation of caspase activity GO:0043281 97 65 1,000 0,0294461 0,07426099 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,0294461 0,07417965 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,0294461 0,07409849 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,0311369 0,07826761 ! acute inflammatory response GO:0002526 92 68 1,000 0,03199646 0,08034046 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,03199646 0,08025285 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03248354 0,08138576 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03248354 0,08129721 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03248354 0,08120884 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03248354 0,08112066 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03248354 0,08103268 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03248354 0,08094489 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03248354 0,08085729 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03248354 0,08076987 ! phosphate transport GO:0006817 10 8 0,000 0,03248354 0,08068265 ! N-glycan processing GO:0006491 12 8 0,000 0,03248354 0,08059561 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03248354 0,08050876 ! UTP metabolic process GO:0046051 8 8 0,000 0,03248354 0,0804221 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03248354 0,08033563 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03248354 0,08024934 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03248354 0,08016323 ! succinate metabolic process GO:0006105 14 8 0,000 0,03248354 0,08007731 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,03248354 0,07999158 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03248354 0,07990602 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03248354 0,07982065 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03248354 0,07973547 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03248354 0,07965046 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03248354 0,07956564 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03248354 0,07948099 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03248354 0,07939653 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03248354 0,07931224 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03248354 0,07922814 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03248354 0,07914421 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03248354 0,07906046 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03248354 0,07897688 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03248354 0,07889349 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03248354 0,07881027 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03248354 0,07872722 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03248354 0,07864435 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03248354 0,07856165 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03248354 0,07847913 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03248354 0,07839678 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03248354 0,0783146 ! melanin metabolic process GO:0006582 12 8 0,000 0,03248354 0,0782326 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03248354 0,07815077 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03248354 0,0780691 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03248354 0,07798761 ! macrophage activation GO:0042116 12 8 0,000 0,03248354 0,07790629 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03248354 0,07782514 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03248354 0,07774415 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03248354 0,07766334 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03248354 0,07758269 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03248354 0,07750221 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03248354 0,0774219 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03248354 0,07734175 ! ruffle organization GO:0031529 11 8 0,000 0,03248354 0,07726177 ! osteoblast development GO:0002076 13 8 0,000 0,03248354 0,07718195 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03248354 0,0771023 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03248354 0,07702282 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03248354 0,07694349 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03248354 0,07686433 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03248354 0,07678534 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03248354 0,0767065 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03248354 0,07662783 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03248354 0,07654932 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03248354 0,07647096 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03248354 0,07639277 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03248354 0,07631474 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03248354 0,07623687 ! segment specification GO:0007379 10 8 0,000 0,03248354 0,07615916 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03248354 0,0760816 ! cellular extravasation GO:0045123 11 8 0,000 0,03248354 0,0760042 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03248354 0,07592696 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03248354 0,07584988 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03248354 0,07577295 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03248354 0,07569618 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03248354 0,07561957 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03248354 0,07554311 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03248354 0,0754668 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03248354 0,07539065 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03248354 0,07531465 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03248354 0,0752388 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03248354 0,07516311 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03248354 0,07508757 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03248354 0,07501218 ! icosanoid secretion GO:0032309 12 8 0,000 0,03248354 0,07493694 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03248354 0,07486186 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03248354 0,07478692 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03248354 0,07471213 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03248354 0,07463749 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03248354 0,07456301 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03248354 0,07448867 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03248354 0,07441447 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03248354 0,07434043 ! sterol catabolic process GO:0016127 9 8 0,000 0,03248354 0,07426653 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03248354 0,07419278 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03248354 0,07411918 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03248354 0,07404572 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03248354 0,07397241 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03248354 0,07389924 ! S phase GO:0051320 8 8 0,000 0,03248354 0,07382622 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03248354 0,07375334 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03248354 0,0736806 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03248354 0,07360801 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03248354 0,07353556 ! hormone catabolic process GO:0042447 13 8 0,000 0,03248354 0,07346326 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03248354 0,07339109 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03248354 0,07331907 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03248354 0,07324719 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03248354 0,07317545 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03248354 0,07310385 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03248354 0,07303239 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03248354 0,07296107 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03248354 0,07288988 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03248354 0,07281884 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03248354 0,07274794 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03248354 0,07267717 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03248354 0,07260654 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03248354 0,07253605 GO:0000076|DNA replication checkpoint, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03248354 0,0724657 ! response to drug GO:0042493 108 69 1,000 0,03286535 0,07324641 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,03286535 0,07317551 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,03463073 0,07703161 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,03463073 0,07695718 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,03463073 0,0768829 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,03552705 0,07879674 ! response to hypoxia GO:0001666 132 72 1,000 0,03552705 0,07872083 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,03643234 0,08064908 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,0364701 0,08065502 ! telencephalon cell migration GO:0022029 16 9 0,000 0,0364701 0,08057754 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,0364701 0,08050022 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,0364701 0,08042303 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,0364701 0,080346 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,0364701 0,08026911 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0364701 0,08019238 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,0364701 0,08011578 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,0364701 0,08003934 ! GTP metabolic process GO:0046039 9 9 0,000 0,0364701 0,07996304 ! elastic fiber assembly GO:0048251 13 9 0,000 0,0364701 0,07988688 ! social behavior GO:0035176 14 9 0,000 0,0364701 0,07981087 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,0364701 0,079735 ! artery development GO:0060840 19 9 0,000 0,0364701 0,07965928 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,0364701 0,0795837 ! response to pain GO:0048265 16 9 0,000 0,0364701 0,07950827 ! protein complex disassembly GO:0043241 17 9 0,000 0,0364701 0,07943298 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,0364701 0,07935783 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,0364701 0,07928282 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,0364701 0,07920795 ! lung alveolus development GO:0048286 17 9 0,000 0,0364701 0,07913323 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,0364701 0,07905865 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,0364701 0,0789842 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,0364701 0,0789099 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,0364701 0,07883574 ! ventral spinal cord development GO:0021517 11 9 0,000 0,0364701 0,07876171 ! protein targeting to ER GO:0045047 19 9 0,000 0,0364701 0,07868783 ! T cell selection GO:0045058 18 9 0,000 0,0364701 0,07861408 ! endoderm development GO:0007492 12 9 0,000 0,0364701 0,07854047 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,0364701 0,078467 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,0364701 0,07839367 ! arginine catabolic process GO:0006527 10 9 0,000 0,0364701 0,07832047 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,0364701 0,07824741 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,0364701 0,07817449 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,0364701 0,0781017 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,0364701 0,07802905 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,0364701 0,07795653 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,0364701 0,07788415 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,0364701 0,0778119 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,0364701 0,07773978 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0364701 0,0776678 ! mannose metabolic process GO:0006013 9 9 0,000 0,0364701 0,07759595 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,0364701 0,07752424 ! epithelial cell development GO:0002064 10 9 0,000 0,0364701 0,07745265 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,0364701 0,0773812 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,0364701 0,07730988 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,0364701 0,0772387 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,0364701 0,07716764 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,0364701 0,07709671 ! motor axon guidance GO:0008045 14 9 0,000 0,0364701 0,07702592 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,0364701 0,07695525 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,0364701 0,07688472 ! blastoderm segmentation GO:0007350 11 9 0,000 0,0364701 0,07681431 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,0364701 0,07674403 ! DNA ligation GO:0006266 14 9 0,000 0,0364701 0,07667388 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,0364701 0,07660386 ! response to amine stimulus GO:0014075 13 9 0,000 0,0364701 0,07653396 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,0364701 0,0764642 ! erythrocyte development GO:0048821 11 9 0,000 0,0364701 0,07639456 ! renal water homeostasis GO:0003091 14 9 0,000 0,0364701 0,07632504 ! postreplication repair GO:0006301 11 9 0,000 0,0364701 0,07625566 ! mRNA cleavage GO:0006379 13 9 0,000 0,0364701 0,0761864 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,0364701 0,07611726 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,0364701 0,07604825 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,0364701 0,07597937 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,0364701 0,07591061 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,0364701 0,07584197 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,0364701 0,07577346 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,0364701 0,07570508 ! acid secretion GO:0046717 14 9 0,000 0,0364701 0,07563681 ! musculoskeletal movement GO:0050881 11 9 0,000 0,0364701 0,07556867 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,0364701 0,07550065 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,0364701 0,07543276 ! purine base metabolic process GO:0006144 18 9 0,000 0,0364701 0,07536498 ! thymus development GO:0048538 15 9 0,000 0,0364701 0,07529733 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,0364701 0,0752298 ! spleen development GO:0048536 15 9 0,000 0,0364701 0,07516239 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,0364701 0,0750951 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,0364701 0,07502793 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,0364701 0,07496088 ! detection of calcium ion GO:0005513 13 9 0,000 0,0364701 0,07489395 ! blastocyst formation GO:0001825 12 9 0,000 0,0364701 0,07482714 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,0364701 0,07476045 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,0364701 0,07469388 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,0364701 0,07462742 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,0364701 0,07456109 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0364701 0,07449487 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,0364701 0,07442877 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,0364701 0,07436279 ! prepulse inhibition GO:0060134 14 9 0,000 0,0364701 0,07429692 ! embryonic placenta development GO:0001892 12 9 0,000 0,0364701 0,07423117 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,0364701 0,07416554 ! insulin secretion GO:0030073 17 9 0,000 0,0364701 0,07410002 ! sequestering of metal ion GO:0051238 11 9 0,000 0,0364701 0,07403462 ! response to nicotine GO:0035094 16 9 0,000 0,0364701 0,07396933 ! establishment of cell polarity GO:0030010 12 9 0,000 0,0364701 0,07390416 ! nucleus localization GO:0051647 15 9 0,000 0,0364701 0,07383911 ! regulation of synapse organization GO:0050807 12 9 0,000 0,0364701 0,07377416 ! response to oxygen levels GO:0070482 137 74 1,000 0,03734652 0,07548066 ! protein import into nucleus GO:0006606 118 74 1,000 0,03734652 0,07541439 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03734652 0,07534824 ! response to nutrient GO:0007584 104 75 1,000 0,03826949 0,0771427 ! regulation of ligase activity GO:0051340 114 75 1,000 0,03826949 0,07707515 ! nuclear import GO:0051170 121 75 1,000 0,03826949 0,07700772 ! response to unfolded protein GO:0006986 99 76 1,000 0,03920117 0,07881354 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,04014148 0,08063354 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,04014148 0,08056318 ! protein ubiquitination GO:0016567 125 77 1,000 0,04014148 0,08049294 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04044046 0,08102183 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04044046 0,08095131 ! neuron fate specification GO:0048665 11 10 0,000 0,04044046 0,08088092 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04044046 0,08081065 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04044046 0,0807405 ! thyroid gland development GO:0030878 19 10 0,000 0,04044046 0,08067048 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04044046 0,08060057 ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04044046 0,08053079 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04044046 0,08046112 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04044046 0,08039158 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04044046 0,08032216 ! sulfate transport GO:0008272 12 10 0,000 0,04044046 0,08025286 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04044046 0,08018367 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,04044046 0,08011461 ! androgen metabolic process GO:0008209 13 10 0,000 0,04044046 0,08004566 ! phospholipid efflux GO:0033700 16 10 0,000 0,04044046 0,07997684 ! hippocampus development GO:0021766 19 10 0,000 0,04044046 0,07990813 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04044046 0,07983954 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04044046 0,07977106 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04044046 0,07970271 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04044046 0,07963447 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04044046 0,07956635 ! pathogenesis GO:0009405 13 10 0,000 0,04044046 0,07949834 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04044046 0,07943045 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04044046 0,07936268 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04044046 0,07929502 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04044046 0,07922748 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04044046 0,07916005 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04044046 0,07909274 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04044046 0,07902554 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04044046 0,07895845 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04044046 0,07889148 ! B cell proliferation GO:0042100 14 10 0,000 0,04044046 0,07882463 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04044046 0,07875788 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04044046 0,07869125 ! forebrain cell migration GO:0021885 17 10 0,000 0,04044046 0,07862473 ! lipid digestion GO:0044241 15 10 0,000 0,04044046 0,07855833 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04044046 0,07849203 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04044046 0,07842585 ! UV protection GO:0009650 14 10 0,000 0,04044046 0,07835978 ! entry into host cell GO:0030260 20 10 0,000 0,04044046 0,07829382 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04044046 0,07822797 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04044046 0,07816223 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04044046 0,07809661 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04044046 0,07803109 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04044046 0,07796568 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04044046 0,07790038 ! regulation of organ growth GO:0046620 11 10 0,000 0,04044046 0,0778352 ! response to dsRNA GO:0043331 18 10 0,000 0,04044046 0,07777012 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04044046 0,07770515 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04044046 0,07764028 ! embryonic axis specification GO:0000578 12 10 0,000 0,04044046 0,07757553 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04044046 0,07751088 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04044046 0,07744634 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04044046 0,07738191 ! cranial nerve development GO:0021545 12 10 0,000 0,04044046 0,07731759 ! fucose catabolic process GO:0019317 16 10 0,000 0,04044046 0,07725337 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,04044046 0,07718926 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04044046 0,07712526 ! protein sumoylation GO:0016925 12 10 0,000 0,04044046 0,07706136 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04044046 0,07699757 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04044046 0,07693388 ! zymogen activation GO:0031638 14 10 0,000 0,04044046 0,0768703 ! salivary gland development GO:0007431 22 10 0,000 0,04044046 0,07680682 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04044046 0,07674345 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04044046 0,07668018 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04044046 0,07661702 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04044046 0,07655396 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04044046 0,076491 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04044046 0,07642815 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04044046 0,0763654 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04044046 0,07630276 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04044046 0,07624021 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04044046 0,07617777 ! detection of bacterium GO:0016045 10 10 0,000 0,04044046 0,07611543 ! embryonic gut development GO:0048566 11 10 0,000 0,04044046 0,0760532 ! activation of innate immune response GO:0002218 10 10 0,000 0,04044046 0,07599106 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04044046 0,07592903 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04044046 0,0758671 ! developmental induction GO:0031128 13 10 0,000 0,04044046 0,07580526 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04044046 0,07574353 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04044046 0,0756819 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04044046 0,07562037 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,04109033 0,07677315 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,04109033 0,07671084 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,04204763 0,07843435 ! T cell activation GO:0042110 134 79 1,000 0,04204763 0,07837079 ! regulation of lyase activity GO:0051339 133 79 1,000 0,04204763 0,07830733 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,04204763 0,07824397 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,04301331 0,07997624 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,04301331 0,07991164 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,04398728 0,08165516 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,04398728 0,08158931 ! response to protein stimulus GO:0051789 111 81 1,000 0,04398728 0,08152356 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,04398728 0,08145792 GO:0002696|positive regulation of leukocyte activation, ! rRNA transcription GO:0009303 17 11 0,000 0,04439469 0,08214625 ! respiratory burst GO:0045730 14 11 0,000 0,04439469 0,08208021 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04439469 0,08201429 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04439469 0,08194846 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04439469 0,08188275 ! filopodium assembly GO:0046847 19 11 0,000 0,04439469 0,08181714 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04439469 0,08175163 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04439469 0,08168623 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04439469 0,08162093 ! mating GO:0007618 14 11 0,000 0,04439469 0,08155574 ! T cell proliferation GO:0042098 20 11 0,000 0,04439469 0,08149065 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04439469 0,08142567 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04439469 0,08136079 ! bone resorption GO:0045453 16 11 0,000 0,04439469 0,08129601 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04439469 0,08123133 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04439469 0,08116676 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04439469 0,08110229 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04439469 0,08103793 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04439469 0,08097366 ! syncytium formation GO:0006949 15 11 0,000 0,04439469 0,0809095 ! plasma membrane organization GO:0007009 18 11 0,000 0,04439469 0,08084544 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04439469 0,08078148 ! focal adhesion formation GO:0048041 24 11 0,000 0,04439469 0,08071762 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04439469 0,08065386 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04439469 0,0805902 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04439469 0,08052664 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04439469 0,08046319 ! adult heart development GO:0007512 11 11 0,000 0,04439469 0,08039983 ! temperature homeostasis GO:0001659 16 11 0,000 0,04439469 0,08033657 ! L-glutamate transport GO:0015813 16 11 0,000 0,04439469 0,08027342 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04439469 0,08021036 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04439469 0,0801474 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04439469 0,08008454 ! stem cell development GO:0048864 29 11 0,000 0,04439469 0,08002178 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04439469 0,07995911 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04439469 0,07989655 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04439469 0,07983408 ! vasoconstriction GO:0042310 15 11 0,000 0,04439469 0,07977171 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04439469 0,07970943 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04439469 0,07964726 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04439469 0,07958518 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04439469 0,0795232 ! ribosome assembly GO:0042255 13 11 0,000 0,04439469 0,07946131 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04439469 0,07939952 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04439469 0,07933783 ! chromatin silencing GO:0006342 19 11 0,000 0,04439469 0,07927623 ! nucleosome positioning GO:0016584 13 11 0,000 0,04439469 0,07921473 ! T cell homeostasis GO:0043029 20 11 0,000 0,04439469 0,07915332 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04439469 0,07909201 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04439469 0,07903079 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04439469 0,07896967 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04439469 0,07890864 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04439469 0,07884771 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04439469 0,07878687 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04439469 0,07872613 ! oxygen transport GO:0015671 15 11 0,000 0,04439469 0,07866547 ! male genitalia development GO:0030539 13 11 0,000 0,04439469 0,07860492 ! cholesterol efflux GO:0033344 19 11 0,000 0,04439469 0,07854445 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04439469 0,07848408 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04439469 0,0784238 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04439469 0,07836361 ! germ cell migration GO:0008354 18 11 0,000 0,04439469 0,07830352 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04439469 0,07824351 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,04439469 0,0781836 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,04439469 0,07812378 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04439469 0,07806406 ! lysogeny GO:0030069 18 11 0,000 0,04439469 0,07800442 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04439469 0,07794487 ! acrosome reaction GO:0007340 13 11 0,000 0,04439469 0,07788542 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04439469 0,07782606 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,04595976 0,08050833 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! sterol metabolic process GO:0016125 120 84 1,000 0,0469581 0,08219454 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,04796441 0,08389212 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,04796441 0,08382837 ! lactation GO:0007595 20 12 0,000 0,04833285 0,08440816 ! reproductive cellular process GO:0048610 14 12 0,000 0,04833285 0,08434412 ! tRNA modification GO:0006400 14 12 0,000 0,04833285 0,08428018 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04833285 0,08421633 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04833285 0,08415258 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04833285 0,08408892 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04833285 0,08402536 ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04833285 0,0839619 ! peroxisomal transport GO:0043574 21 12 0,000 0,04833285 0,08389853 ! cartilage condensation GO:0001502 18 12 0,000 0,04833285 0,08383526 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04833285 0,08377208 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04833285 0,083709 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04833285 0,08364601 ! heart looping GO:0001947 15 12 0,000 0,04833285 0,08358312 ! palate development GO:0060021 15 12 0,000 0,04833285 0,08352032 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04833285 0,08345762 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04833285 0,08339501 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04833285 0,0833325 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04833285 0,08327008 ! arginine metabolic process GO:0006525 13 12 0,000 0,04833285 0,08320775 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04833285 0,08314551 ! methionine metabolic process GO:0006555 13 12 0,000 0,04833285 0,08308337 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04833285 0,08302132 ! Golgi organization GO:0007030 18 12 0,000 0,04833285 0,08295937 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,04833285 0,0828975 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04833285 0,08283573 ! monoamine transport GO:0015844 13 12 0,000 0,04833285 0,08277405 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04833285 0,08271246 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04833285 0,08265097 ! L-amino acid transport GO:0015807 20 12 0,000 0,04833285 0,08258956 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04833285 0,08252825 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04833285 0,08246703 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04833285 0,08240589 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04833285 0,08234485 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04833285 0,0822839 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04833285 0,08222304 ! cerebellum development GO:0021549 13 12 0,000 0,04833285 0,08216227 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04833285 0,08210159 ! histone methylation GO:0016571 15 12 0,000 0,04833285 0,082041 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04833285 0,0819805 ! gland morphogenesis GO:0022612 23 12 0,000 0,04833285 0,08192008 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04833285 0,08185976 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04833285 0,08179952 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04833285 0,08173938 ! intestinal absorption GO:0050892 19 12 0,000 0,04833285 0,08167932 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04833285 0,08161935 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04833285 0,08155947 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04833285 0,08149967 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04833285 0,08143996 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04833285 0,08138035 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04833285 0,08132081 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04833285 0,08126137 ! microspike assembly GO:0030035 23 12 0,000 0,04833285 0,08120201 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04833285 0,08114274 ! response to cold GO:0009409 14 12 0,000 0,04833285 0,08108355 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,0489786 0,08210698 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,05000059 0,08375919 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,05000059 0,08369823 GO:0060538|skeletal muscle organ development, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,05103031 0,08535979 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,05103031 0,08529776 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,05206767 0,08696852 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,05206767 0,0869054 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,05206767 0,08684238 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,052255 0,08709167 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,052255 0,08702861 ! cGMP metabolic process GO:0046068 16 13 0,000 0,052255 0,08696563 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,052255 0,08690275 ! water transport GO:0006833 17 13 0,000 0,052255 0,08683996 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,052255 0,08677726 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,052255 0,08671465 ! lipid localization GO:0010876 24 13 0,000 0,052255 0,08665213 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,052255 0,0865897 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,052255 0,08652736 ! organelle fusion GO:0048284 28 13 0,000 0,052255 0,08646511 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,052255 0,08640295 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,052255 0,08634088 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,052255 0,0862789 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,052255 0,08621701 ! response to hexose stimulus GO:0009746 19 13 0,000 0,052255 0,0861552 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,052255 0,08609349 ! glutamate metabolic process GO:0006536 18 13 0,000 0,052255 0,08603186 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,052255 0,08597032 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,052255 0,08590887 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,052255 0,08584751 ! NAD metabolic process GO:0019674 21 13 0,000 0,052255 0,08578623 ! exocrine system development GO:0035272 27 13 0,000 0,052255 0,08572504 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,052255 0,08566394 ! bone mineralization GO:0030282 15 13 0,000 0,052255 0,08560293 ! regulation of exocytosis GO:0017157 17 13 0,000 0,052255 0,085542 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,052255 0,08548116 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,052255 0,0854204 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,052255 0,08535974 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,052255 0,08529915 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,052255 0,08523866 ! genitalia development GO:0048806 15 13 0,000 0,052255 0,08517825 ! cellular pigmentation GO:0033059 24 13 0,000 0,052255 0,08511792 ! tissue regeneration GO:0042246 21 13 0,000 0,052255 0,08505768 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,052255 0,08499753 ! cofactor transport GO:0051181 19 13 0,000 0,052255 0,08493746 ! NADP metabolic process GO:0006739 18 13 0,000 0,052255 0,08487748 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,052255 0,08481758 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,052255 0,08475776 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,052255 0,08469803 ! gas transport GO:0015669 18 13 0,000 0,052255 0,08463839 ! regulation of RNA stability GO:0043487 28 13 0,000 0,052255 0,08457882 ! heme biosynthetic process GO:0006783 20 13 0,000 0,052255 0,08451934 ! regulation of axon extension GO:0030516 23 13 0,000 0,052255 0,08445995 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,052255 0,08440064 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,052255 0,08434141 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,052255 0,08428226 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,052255 0,0842232 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,052255 0,08416422 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,052255 0,08410532 ! leukocyte differentiation GO:0002521 143 90 1,000 0,0531126 0,08542586 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,0531126 0,08536616 ! response to virus GO:0009615 122 91 1,000 0,05416501 0,08699688 ! ATP metabolic process GO:0046034 137 91 1,000 0,05416501 0,08693617 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,05522484 0,08857541 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,05522484 0,08851368 ! cell fate commitment GO:0045165 141 92 1,000 0,05522484 0,08845204 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05616122 0,08988921 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,05616122 0,0898267 ! superoxide anion generation GO:0042554 18 14 0,000 0,05616122 0,08976428 ! neuron maturation GO:0042551 21 14 0,000 0,05616122 0,08970194 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05616122 0,08963969 ! myotube differentiation GO:0014902 21 14 0,000 0,05616122 0,08957753 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05616122 0,08951545 ! inositol metabolic process GO:0006020 20 14 0,000 0,05616122 0,08945346 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05616122 0,08939156 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05616122 0,08932974 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05616122 0,089268 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05616122 0,08920635 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05616122 0,08914479 ! response to cAMP GO:0051591 19 14 0,000 0,05616122 0,08908331 ! limbic system development GO:0021761 25 14 0,000 0,05616122 0,08902191 ! startle response GO:0001964 21 14 0,000 0,05616122 0,0889606 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,05616122 0,08889938 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05616122 0,08883824 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,05616122 0,08877718 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05616122 0,08871621 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05616122 0,08865532 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05616122 0,08859451 ! glycine metabolic process GO:0006544 22 14 0,000 0,05616122 0,08853379 ! pituitary gland development GO:0021983 23 14 0,000 0,05616122 0,08847315 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05616122 0,08841259 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,05616122 0,08835212 ! regulation of heart rate GO:0002027 23 14 0,000 0,05616122 0,08829173 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05616122 0,08823142 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05616122 0,08817119 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05616122 0,08811105 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05616122 0,08805099 ! intermediate filament-based process GO:0045103 24 14 0,000 0,05616122 0,08799101 ! axon cargo transport GO:0008088 27 14 0,000 0,05616122 0,08793111 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05616122 0,08787129 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05616122 0,08781156 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05616122 0,0877519 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05616122 0,08769233 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05616122 0,08763283 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05616122 0,08757342 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05616122 0,08751409 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05616122 0,08745484 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05616122 0,08739567 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05616122 0,08733658 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05616122 0,08727757 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05616122 0,08721863 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,05616122 0,08715978 ! muscle maintenance GO:0046716 19 14 0,000 0,05616122 0,08710101 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05616122 0,08704232 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05616122 0,0869837 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05616122 0,08692517 ! cell killing GO:0001906 20 14 0,000 0,05616122 0,08686671 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,05616122 0,08680833 ! cilium assembly GO:0042384 20 14 0,000 0,05616122 0,08675003 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05616122 0,08669181 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,05953671 0,09184067 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,06005155 0,09257277 ! positive regulation of cell size GO:0045793 20 15 0,000 0,06005155 0,09251076 ! metencephalon development GO:0022037 19 15 0,000 0,06005155 0,09244884 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,06005155 0,092387 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,06005155 0,09232525 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,06005155 0,09226357 ! skin development GO:0043588 25 15 0,000 0,06005155 0,09220198 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,06005155 0,09214047 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,06005155 0,09207905 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,06005155 0,0920177 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,06005155 0,09195644 ! bile acid metabolic process GO:0008206 22 15 0,000 0,06005155 0,09189526 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,06005155 0,09183416 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,06005155 0,09177314 ! adult walking behavior GO:0007628 25 15 0,000 0,06005155 0,0917122 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,06005155 0,09165134 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,06005155 0,09159056 ! myoblast differentiation GO:0045445 27 15 0,000 0,06005155 0,09152987 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,06005155 0,09146925 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,06005155 0,09140872 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,06005155 0,09134826 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,06005155 0,09128789 ! cerebral cortex development GO:0021987 29 15 0,000 0,06005155 0,09122759 ! response to osmotic stress GO:0006970 22 15 0,000 0,06005155 0,09116737 ! vesicle coating GO:0006901 25 15 0,000 0,06005155 0,09110724 ! DNA integration GO:0015074 22 15 0,000 0,06005155 0,09104718 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,06005155 0,0909872 ! peptide secretion GO:0002790 27 15 0,000 0,06005155 0,0909273 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,06005155 0,09086748 ! regulation of vasodilation GO:0042312 24 15 0,000 0,06005155 0,09080774 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,06005155 0,09074808 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,06005155 0,09068849 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,06005155 0,09062898 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,06005155 0,09056955 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,06005155 0,0905102 ! biomineral formation GO:0031214 18 15 0,000 0,06005155 0,09045093 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,06005155 0,09039173 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,06005155 0,09033262 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,06005155 0,09027358 ! dopamine metabolic process GO:0042417 30 15 0,000 0,06005155 0,09021461 ! organic cation transport GO:0015695 19 15 0,000 0,06005155 0,09015573 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,06005155 0,09009692 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,06005155 0,09003818 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,06005155 0,08997952 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,06005155 0,08992094 ! peptide hormone processing GO:0016486 19 15 0,000 0,06005155 0,08986244 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,06005155 0,08980401 ! calcium ion transport GO:0006816 167 99 1,000 0,0628447 0,09391996 ! protein import GO:0017038 156 99 1,000 0,0628447 0,09385897 ! protein secretion GO:0009306 27 16 0,000 0,06392608 0,09541205 ! hormone secretion GO:0046879 25 16 0,000 0,06392608 0,09535018 ! bone remodeling GO:0046849 24 16 0,000 0,06392608 0,09528838 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06392608 0,09522667 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06392608 0,09516503 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06392608 0,09510348 ! glial cell development GO:0021782 24 16 0,000 0,06392608 0,095042 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06392608 0,0949806 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06392608 0,09491929 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06392608 0,09485805 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06392608 0,09479689 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,06392608 0,09473581 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,06392608 0,09467481 ! fructose metabolic process GO:0006000 20 16 0,000 0,06392608 0,09461388 ! regulation of protein binding GO:0043393 27 16 0,000 0,06392608 0,09455304 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,06392608 0,09449227 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06392608 0,09443158 ! protein export from nucleus GO:0006611 24 16 0,000 0,06392608 0,09437097 ! negative regulation of immune response GO:0050777 28 16 0,000 0,06392608 0,09431044 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06392608 0,09424998 ! DNA replication initiation GO:0006270 25 16 0,000 0,06392608 0,0941896 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,06392608 0,0941293 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06392608 0,09406908 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06392608 0,09400893 ! diencephalon development GO:0021536 25 16 0,000 0,06392608 0,09394886 ! neural crest cell migration GO:0001755 24 16 0,000 0,06392608 0,09388887 ! G1 phase GO:0051318 27 16 0,000 0,06392608 0,09382896 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06392608 0,09376912 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,06392608 0,09370935 ! steroid catabolic process GO:0006706 22 16 0,000 0,06392608 0,09364966 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,06392608 0,09359005 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06392608 0,09353052 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06392608 0,09347106 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06392608 0,09341167 GO:0007339|binding of sperm to zona pellucida, ! nerve development GO:0021675 18 16 0,000 0,06392608 0,09335236 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06392608 0,09329313 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,06392608 0,09323397 ! negative regulation of translation GO:0017148 22 16 0,000 0,06392608 0,09317489 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,06396108 0,09316687 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,06396108 0,09310791 ! divalent metal ion transport GO:0070838 171 100 1,000 0,06396108 0,09304901 ! protein localization in organelle GO:0033365 161 100 1,000 0,06396108 0,0929902 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06778485 0,09848714 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06778485 0,09842497 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06778485 0,09836287 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,06778485 0,09830085 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06778485 0,09823891 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06778485 0,09817705 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06778485 0,09811526 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06778485 0,09805355 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06778485 0,09799192 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06778485 0,09793037 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06778485 0,0978689 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06778485 0,0978075 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06778485 0,09774618 ! memory GO:0007613 25 17 0,000 0,06778485 0,09768493 ! keratinization GO:0031424 17 17 0,000 0,06778485 0,09762376 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06778485 0,09756267 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06778485 0,09750166 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06778485 0,09744072 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06778485 0,09737986 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06778485 0,09731907 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06778485 0,09725836 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06778485 0,09719772 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,06778485 0,09713717 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06778485 0,09707668 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06778485 0,09701627 ! membrane budding GO:0006900 29 17 0,000 0,06778485 0,09695594 ! heme metabolic process GO:0042168 27 17 0,000 0,06778485 0,09689568 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06778485 0,0968355 ! neuromuscular junction development GO:0007528 23 17 0,000 0,06778485 0,09677539 ! body fluid secretion GO:0007589 27 17 0,000 0,06778485 0,09671535 ! stem cell differentiation GO:0048863 36 17 0,000 0,06778485 0,09665539 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06778485 0,09659551 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06778485 0,0965357 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06778485 0,09647596 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06778485 0,0964163 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06778485 0,09635671 ! synaptogenesis GO:0007416 24 17 0,000 0,06778485 0,09629719 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06778485 0,09623775 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06778485 0,09617838 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06778485 0,09611908 ! cell-cell junction organization GO:0045216 25 17 0,000 0,06778485 0,09605986 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06778485 0,09600071 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06778485 0,09594163 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06778485 0,09588263 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,06778485 0,09582369 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06778485 0,09576483 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06778485 0,09570605 ! positive regulation of translation GO:0045727 28 18 0,000 0,07162793 0,10107009 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,07162793 0,10100812 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,07162793 0,10094623 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,07162793 0,10088441 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,07162793 0,10082267 ! cAMP metabolic process GO:0046058 33 18 0,000 0,07162793 0,10076101 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,07162793 0,10069942 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,07162793 0,1006379 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,07162793 0,10057646 ! axis specification GO:0009798 26 18 0,000 0,07162793 0,1005151 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,07162793 0,10045381 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,07162793 0,10039259 ! pancreas development GO:0031016 26 18 0,000 0,07162793 0,10033145 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,07162793 0,10027039 ! glutamine metabolic process GO:0006541 23 18 0,000 0,07162793 0,1002094 ! response to retinoic acid GO:0032526 25 18 0,000 0,07162793 0,10014848 ! pigmentation during development GO:0048066 31 18 0,000 0,07162793 0,10008763 ! central nervous system neuron development GO:0021954 30 18 0,000 0,07162793 0,10002687 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,07162793 0,09996617 ! fucose metabolic process GO:0006004 26 18 0,000 0,07162793 0,09990555 ! response to fungus GO:0009620 19 18 0,000 0,07162793 0,099845 ! peptide cross-linking GO:0018149 31 18 0,000 0,07162793 0,09978452 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,07162793 0,09972412 ! heart process GO:0003015 27 18 0,000 0,07162793 0,09966379 GO:0060047|heart contraction, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,07162793 0,09960354 ! visual learning GO:0008542 35 18 0,000 0,07162793 0,09954335 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,07162793 0,09948324 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,07162793 0,0994232 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,07162793 0,09936324 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,07162793 0,09930334 ! vitamin transport GO:0051180 24 18 0,000 0,07162793 0,09924352 ! hormone transport GO:0009914 27 18 0,000 0,07162793 0,09918377 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,07162793 0,0991241 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,07162793 0,09906449 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,07162793 0,09900496 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,07162793 0,09894549 ! cell-cell recognition GO:0009988 20 18 0,000 0,07162793 0,0988861 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,07162793 0,09882678 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,07162793 0,09876753 ! gut development GO:0048565 26 18 0,000 0,07162793 0,09870836 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,07162793 0,09864925 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,07162793 0,09859021 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,0754554 0,1037963 ! positive regulation of ossification GO:0045778 30 19 0,000 0,0754554 0,10373426 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,0754554 0,10367229 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,0754554 0,10361039 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,0754554 0,10354857 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,0754554 0,10348683 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,0754554 0,10342515 ! regeneration GO:0031099 32 19 0,000 0,0754554 0,10336355 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,0754554 0,10330203 ! response to alkaloid GO:0043279 32 19 0,000 0,0754554 0,10324058 ! sensory perception of taste GO:0050909 23 19 0,000 0,0754554 0,1031792 ! smooth muscle contraction GO:0006939 36 19 0,000 0,0754554 0,10311789 ! peroxisome organization GO:0007031 29 19 0,000 0,0754554 0,10305666 ! digestive system process GO:0022600 30 19 0,000 0,0754554 0,10299549 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,0754554 0,10293441 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,0754554 0,10287339 ! response to vitamin A GO:0033189 26 19 0,000 0,0754554 0,10281245 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,0754554 0,10275157 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,0754554 0,10269077 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,0754554 0,10263005 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,0754554 0,10256939 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,0754554 0,10250881 ! plasma membrane fusion GO:0045026 23 19 0,000 0,0754554 0,10244829 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,0754554 0,10238785 ! cytolysis GO:0019835 20 19 0,000 0,0754554 0,10232748 ! renal system process GO:0003014 35 19 0,000 0,0754554 0,10226718 ! vasodilation GO:0042311 33 19 0,000 0,0754554 0,10220695 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,0754554 0,1021468 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,0754554 0,10208671 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,0754554 0,1020267 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,0754554 0,10196675 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,0754554 0,10190688 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,0754554 0,10184707 ! sarcomere organization GO:0045214 23 19 0,000 0,0754554 0,10178734 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,0754554 0,10172767 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,0754554 0,10166808 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,0754554 0,10160855 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,0754554 0,1015491 GO:0043450|alkene biosynthetic process, ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,0754554 0,10148971 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,0754554 0,1014304 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,0754554 0,10137115 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,0792673 0,10643011 ! iron ion transport GO:0006826 37 20 0,000 0,0792673 0,10636802 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,0792673 0,10630599 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,0792673 0,10624404 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,0792673 0,10618217 ! response to vitamin GO:0033273 29 20 0,000 0,0792673 0,10612036 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,0792673 0,10605863 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,0792673 0,10599696 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,0792673 0,10593537 ! spinal cord development GO:0021510 31 20 0,000 0,0792673 0,10587386 ! response to ethanol GO:0045471 37 20 0,000 0,0792673 0,10581241 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,0792673 0,10575103 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,0792673 0,10568973 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,0792673 0,10562849 ! chromosome condensation GO:0030261 31 20 0,000 0,0792673 0,10556733 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,0792673 0,10550624 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,0792673 0,10544522 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,0792673 0,10538427 ! pallium development GO:0021543 38 20 0,000 0,0792673 0,10532338 ! DNA modification GO:0006304 28 20 0,000 0,0792673 0,10526257 ! collagen fibril organization GO:0030199 45 20 0,000 0,0792673 0,10520183 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,0792673 0,10514116 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,0792673 0,10508056 ! collagen catabolic process GO:0030574 25 20 0,000 0,0792673 0,10502003 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,0792673 0,10495957 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,0792673 0,10489918 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,0792673 0,10483886 ! alditol metabolic process GO:0019400 24 20 0,000 0,0792673 0,10477861 ! actin filament-based movement GO:0030048 34 20 0,000 0,0792673 0,10471843 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,0830637 0,10967078 ! regulation of cell killing GO:0031341 34 21 0,000 0,0830637 0,10960786 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,0830637 0,10954501 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,0830637 0,10948224 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,0830637 0,10941953 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,0830637 0,1093569 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,0830637 0,10929434 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,0830637 0,10923185 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,0830637 0,10916943 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,0830637 0,10910708 ! vesicle docking GO:0048278 27 21 0,000 0,0830637 0,10904481 ! phototransduction GO:0007602 25 21 0,000 0,0830637 0,1089826 ! dendrite development GO:0016358 35 21 0,000 0,0830637 0,10892047 ! visual behavior GO:0007632 39 21 0,000 0,0830637 0,10885841 ! ovarian follicle development GO:0001541 30 21 0,000 0,0830637 0,10879641 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,0830637 0,10873449 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,0830637 0,10867264 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,0830637 0,10861086 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,0830637 0,10854915 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,0830637 0,10848751 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,0830637 0,10842594 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,0830637 0,10836444 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,0830637 0,10830301 GO:0060415|muscle tissue morphogenesis, ! leukotriene metabolic process GO:0006691 28 21 0,000 0,0830637 0,10824164 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,0830637 0,10818035 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,0830637 0,10811913 ! fatty acid transport GO:0015908 30 21 0,000 0,0830637 0,10805798 ! platelet activation GO:0030168 28 21 0,000 0,0830637 0,10799689 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,0830637 0,10793588 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,0830637 0,10787493 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,0830637 0,10781405 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,0830637 0,10775324 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,0830637 0,1076925 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,0830637 0,10763183 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,0830637 0,10757123 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,0830637 0,10751069 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,0830637 0,10745023 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,0830637 0,10738983 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,0830637 0,1073295 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,0830637 0,10726923 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,08684466 0,11208907 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,08684466 0,1120262 ! viral genome replication GO:0019079 29 22 0,000 0,08684466 0,11196341 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,08684466 0,11190068 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,08684466 0,11183803 ! leukocyte adhesion GO:0007159 38 22 0,000 0,08684466 0,11177544 ! molting cycle process GO:0022404 40 22 0,000 0,08684466 0,11171293 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,08684466 0,11165049 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,08684466 0,11158811 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,08684466 0,11152581 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,08684466 0,11146357 ! vasculogenesis GO:0001570 33 22 0,000 0,08684466 0,1114014 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,08684466 0,11133931 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,08684466 0,11127728 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,08684466 0,11121532 ! lysosome organization GO:0007040 37 22 0,000 0,08684466 0,11115343 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,08684466 0,11109161 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,08684466 0,11102986 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,08684466 0,11096818 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,08684466 0,11090656 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,08684466 0,11084502 ! membrane depolarization GO:0051899 35 22 0,000 0,08684466 0,11078354 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,08684466 0,11072213 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,08684466 0,11066079 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,08684466 0,11059951 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,08684466 0,11053831 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,08684466 0,11047717 ! neural tube closure GO:0001843 33 22 0,000 0,08684466 0,1104161 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,08684466 0,11035509 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,09061025 0,11507652 ! neuron fate commitment GO:0048663 32 23 0,000 0,09061025 0,11501301 ! embryonic pattern specification GO:0009880 31 23 0,000 0,09061025 0,11494957 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,09061025 0,1148862 ! myelination GO:0042552 35 23 0,000 0,09061025 0,11482291 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,09061025 0,11475968 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,09061025 0,11469652 ! vesicle targeting GO:0006903 32 23 0,000 0,09061025 0,11463343 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,09061025 0,11457041 ! osteoblast differentiation GO:0001649 40 23 0,000 0,09061025 0,11450746 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,09061025 0,11444458 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,09061025 0,11438176 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,09061025 0,11431902 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,09061025 0,11425635 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,09061025 0,11419374 ! glycolipid metabolic process GO:0006664 36 23 0,000 0,09061025 0,1141312 ! cell fate determination GO:0001709 45 23 0,000 0,09061025 0,11406873 ! pentose metabolic process GO:0019321 31 23 0,000 0,09061025 0,11400633 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,09061025 0,113944 ! spermatid development GO:0007286 33 23 0,000 0,09061025 0,11388173 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,09061025 0,11381954 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,09061025 0,11375741 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,09061025 0,11369535 ! telomere organization GO:0032200 32 23 0,000 0,09061025 0,11363336 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,09061025 0,11357143 ! regulation of amine transport GO:0051952 38 23 0,000 0,09061025 0,11350957 ! liver development GO:0001889 40 23 0,000 0,09061025 0,11344778 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,09436052 0,118079 ! initiation of viral infection GO:0019059 42 24 0,000 0,09436052 0,11801479 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,09436052 0,11795066 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,09436052 0,11788659 ! superoxide metabolic process GO:0006801 32 24 0,000 0,09436052 0,11782259 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,09436052 0,11775866 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,09436052 0,1176948 ! fat cell differentiation GO:0045444 37 24 0,000 0,09436052 0,11763101 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,09436052 0,11756728 ! sperm motility GO:0030317 27 24 0,000 0,09436052 0,11750363 ! vacuole organization GO:0007033 39 24 0,000 0,09436052 0,11744005 ! neural crest cell development GO:0014032 39 24 0,000 0,09436052 0,11737653 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,09436052 0,11731309 ! primary neural tube formation GO:0014020 35 24 0,000 0,09436052 0,11724971 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,09436052 0,1171864 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,09436052 0,11712316 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,09436052 0,11705998 ! glutathione metabolic process GO:0006749 29 24 0,000 0,09436052 0,11699688 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,09436052 0,11693384 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,09436052 0,11687087 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,09436052 0,11680797 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,09809555 0,1213662 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,09809555 0,12130095 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,09809555 0,12123577 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,09809555 0,12117066 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,09809555 0,12110562 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,09809555 0,12104064 ! peptide transport GO:0015833 43 25 0,000 0,09809555 0,12097574 ! male gonad development GO:0008584 33 25 0,000 0,09809555 0,12091091 ! iron ion homeostasis GO:0055072 39 25 0,000 0,09809555 0,12084615 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,09809555 0,12078146 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,09809555 0,12071683 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,09809555 0,12065228 ! phospholipid transport GO:0015914 35 25 0,000 0,09809555 0,12058779 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,09809555 0,12052338 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,09809555 0,12045903 ! detection of light stimulus GO:0009583 30 25 0,000 0,09809555 0,12039475 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,09809555 0,12033054 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,09809555 0,1202664 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,09809555 0,12020232 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,10181538 0,12469402 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,10181538 0,12462766 ! translational initiation GO:0006413 43 26 0,000 0,10181538 0,12456137 ! circadian rhythm GO:0007623 42 26 0,000 0,10181538 0,12449515 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,10181538 0,124429 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,10181538 0,12436292 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,10181538 0,12429691 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,10181538 0,12423097 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,10181538 0,1241651 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,10181538 0,1240993 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,10181538 0,12403357 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,10181538 0,12396791 ! regulation of coagulation GO:0050818 39 26 0,000 0,10181538 0,12390232 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,10552008 0,12834278 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,10552008 0,12827494 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,10552008 0,12820718 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,10552008 0,12813949 ! membrane docking GO:0022406 39 27 0,000 0,10552008 0,12807187 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,10552008 0,12800432 ! catechol metabolic process GO:0009712 43 27 0,000 0,10552008 0,12793684 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,10552008 0,12786944 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,10552008 0,1278021 ! myofibril assembly GO:0030239 36 27 0,000 0,10552008 0,12773484 GO:0055002|striated muscle cell development, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,10552008 0,12766765 ! natural killer cell activation GO:0030101 35 27 0,000 0,10552008 0,12760052 ! cofactor catabolic process GO:0051187 45 27 0,000 0,10552008 0,12753347 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,10552008 0,12746649 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,10552008 0,12739958 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,10552008 0,12733274 ! gene silencing GO:0016458 41 27 0,000 0,10552008 0,12726596 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,10920972 0,13164693 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,10920972 0,13157797 ! phenol metabolic process GO:0018958 44 28 0,000 0,10920972 0,13150908 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,10920972 0,13144027 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,10920972 0,13137152 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,10920972 0,13130285 ! cell junction assembly GO:0034329 56 28 0,000 0,10920972 0,13123425 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,10920972 0,13116572 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,10920972 0,13109726 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,10920972 0,13102887 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,10920972 0,13096056 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,10920972 0,13089231 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,10920972 0,13082414 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,10920972 0,13075604 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,10920972 0,13068801 ! mesoderm formation GO:0001707 46 28 0,000 0,10920972 0,13062005 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,10920972 0,13055216 ! ensheathment of neurons GO:0007272 43 28 0,000 0,10920972 0,13048434 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,10920972 0,13041659 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,10920972 0,13034891 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,10920972 0,1302813 ! neural tube formation GO:0001841 41 28 0,000 0,10920972 0,13021376 ! placenta development GO:0001890 37 28 0,000 0,10920972 0,1301463 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,11288434 0,13445572 ! regulation of innate immune response GO:0045088 38 29 0,000 0,11288434 0,13438612 ! ovulation cycle process GO:0022602 41 29 0,000 0,11288434 0,1343166 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,11288434 0,13424715 ! protein targeting to membrane GO:0006612 53 29 0,000 0,11288434 0,13417777 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,11288434 0,13410846 ! muscle cell development GO:0055001 38 29 0,000 0,11288434 0,13403923 ! formation of primary germ layer GO:0001704 48 29 0,000 0,11288434 0,13397007 ! telencephalon development GO:0021537 52 29 0,000 0,11288434 0,13390097 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,11288434 0,13383195 ! eye morphogenesis GO:0048592 51 29 0,000 0,11288434 0,133763 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,11288434 0,13369412 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,11654402 0,13795741 ! collagen metabolic process GO:0032963 40 30 0,000 0,11654402 0,13788644 ! organic anion transport GO:0015711 51 30 0,000 0,11654402 0,13781555 ! cholesterol transport GO:0030301 46 30 0,000 0,11654402 0,13774473 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,11654402 0,13767398 ! spliceosome assembly GO:0000245 49 30 0,000 0,11654402 0,13760331 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,11654402 0,13753271 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,11654402 0,13746218 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,11654402 0,13739172 ! ceramide metabolic process GO:0006672 43 30 0,000 0,11654402 0,13732133 ! ovulation cycle GO:0042698 43 30 0,000 0,11654402 0,13725102 ! hindbrain development GO:0030902 45 30 0,000 0,11654402 0,13718078 ! adult locomotory behavior GO:0008344 47 30 0,000 0,11654402 0,13711061 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,11654402 0,13704051 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,11654402 0,13697049 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,11654402 0,13690053 ! response to heat GO:0009408 41 30 0,000 0,11654402 0,13683065 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,11654402 0,13676084 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,11654402 0,1366911 ! negative regulation of secretion GO:0051048 49 31 0,000 0,12018881 0,14089412 ! glial cell differentiation GO:0010001 55 31 0,000 0,12018881 0,14082234 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,12018881 0,14075064 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,12018881 0,14067901 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,12018881 0,14060745 ! odontogenesis GO:0042476 50 31 0,000 0,12018881 0,14053597 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,12018881 0,14046456 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,12018881 0,14039322 ! metanephros development GO:0001656 58 31 0,000 0,12018881 0,14032196 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,12018881 0,14025076 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,12018881 0,14017964 ! cell fate specification GO:0001708 37 31 0,000 0,12018881 0,14010859 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,12018881 0,14003762 ! RNA modification GO:0009451 40 31 0,000 0,12018881 0,13996671 ! regulation of muscle development GO:0048634 48 32 0,000 0,12381876 0,14412103 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,12381876 0,14404813 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,12381876 0,14397531 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,12381876 0,14390256 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,12381876 0,14382988 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,12381876 0,14375727 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,12381876 0,14368474 ! cytokine production GO:0001816 44 32 0,000 0,12381876 0,14361228 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,12381876 0,1435399 ! vesicle localization GO:0051648 47 32 0,000 0,12381876 0,14346759 ! RNA export from nucleus GO:0006405 44 33 0,000 0,12743395 0,14758212 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,12743395 0,14750785 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,12743395 0,14743365 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,12743395 0,14735952 ! sister chromatid segregation GO:0000819 46 33 0,000 0,12743395 0,14728547 ! ear morphogenesis GO:0042471 42 33 0,000 0,12743395 0,1472115 ! actomyosin structure organization GO:0031032 43 33 0,000 0,12743395 0,1471376 ! cell junction organization GO:0034330 63 33 0,000 0,12743395 0,14706377 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,12743395 0,14699002 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,12743395 0,14691634 ! nucleus organization GO:0006997 49 33 0,000 0,12743395 0,14684273 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,12743395 0,1467692 ! positive regulation of cell development GO:0010720 54 33 0,000 0,12743395 0,14669574 ! lipid homeostasis GO:0055088 55 33 0,000 0,12743395 0,14662236 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,12743395 0,14654905 ! regulation of proteolysis GO:0030162 50 33 0,000 0,12743395 0,14647581 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,12743395 0,14640264 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,12743395 0,14632955 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,12743395 0,14625653 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,13103443 0,15031381 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,13103443 0,15023888 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,13103443 0,15016402 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,13103443 0,15008924 ! feeding behavior GO:0007631 45 34 0,000 0,13103443 0,15001453 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,13103443 0,1499399 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,13103443 0,14986534 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,13103443 0,14979085 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,13103443 0,14971644 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,13103443 0,1496421 ! polyol metabolic process GO:0019751 44 34 0,000 0,13103443 0,14956784 ! aerobic respiration GO:0009060 47 34 0,000 0,13103443 0,14949365 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,13103443 0,14941953 ! embryonic organ development GO:0048568 45 34 0,000 0,13103443 0,14934549 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,13103443 0,14927152 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,13462026 0,15328049 ! Notch signaling pathway GO:0007219 56 35 0,000 0,13462026 0,15320465 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,13462026 0,15312888 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,13462026 0,15305319 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,13462026 0,15297757 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,13462026 0,15290202 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,13462026 0,15282655 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,13462026 0,15275116 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,13462026 0,15267584 ! glycogen metabolic process GO:0005977 48 35 0,000 0,13462026 0,15260059 ! pigment metabolic process GO:0042440 61 35 0,000 0,13462026 0,15252542 ! protein homooligomerization GO:0051260 52 35 0,000 0,13462026 0,15245032 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,1381915 0,15641754 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,1381915 0,1563406 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,1381915 0,15626374 ! organic ether metabolic process GO:0018904 46 36 0,000 0,1381915 0,15618695 ! tissue remodeling GO:0048771 62 36 0,000 0,1381915 0,15611024 ! neural tube development GO:0021915 50 36 0,000 0,1381915 0,1560336 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,1381915 0,15595704 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1381915 0,15588055 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,1381915 0,15580414 ! glucan metabolic process GO:0044042 49 36 0,000 0,1381915 0,1557278 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,1417482 0,15965762 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,1417482 0,15957947 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,1417482 0,1595014 ! learning GO:0007612 67 37 0,000 0,1417482 0,1594234 ! ion transmembrane transport GO:0034220 56 37 0,000 0,1417482 0,15934548 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,1417482 0,15926764 ! regulation of protein secretion GO:0050708 51 37 0,000 0,1417482 0,15918987 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,1417482 0,15911218 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,14529042 0,16300877 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,14529042 0,16292929 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,14529042 0,16284989 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,14529042 0,16277057 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,14529042 0,16269132 ! phagocytosis GO:0006909 60 38 0,000 0,14529042 0,16261215 ! mesenchymal cell development GO:0014031 64 38 0,000 0,14529042 0,16253306 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,14529042 0,16245405 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,14881823 0,16631775 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,14881823 0,16623697 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,14881823 0,16615628 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,14881823 0,16607566 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,14881823 0,16599512 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,14881823 0,16591465 ! male sex differentiation GO:0046661 53 39 0,000 0,14881823 0,16583427 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,14881823 0,16575396 ! chromatin remodeling GO:0006338 68 39 0,000 0,14881823 0,16567373 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,14881823 0,16559358 ! synapse organization GO:0050808 55 39 0,000 0,14881823 0,16551351 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,15233168 0,16933923 ! response to calcium ion GO:0051592 58 40 0,000 0,15233168 0,16925742 ! regulation of tube size GO:0035150 60 40 0,000 0,15233168 0,16917569 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,15233168 0,16909405 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,15233168 0,16901248 ! peptide metabolic process GO:0006518 56 40 0,000 0,15233168 0,16893099 ! inner ear development GO:0048839 57 40 0,000 0,15233168 0,16884957 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,15233168 0,16876824 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,15233168 0,16868698 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,15233168 0,16860581 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,15233168 0,16852471 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,15583083 0,17231293 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,15583083 0,17223013 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,15583083 0,17214741 ! glucose transport GO:0015758 52 41 0,000 0,15583083 0,17206476 ! striated muscle contraction GO:0006941 62 41 0,000 0,15583083 0,1719822 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,15583083 0,17189971 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,15583083 0,17181731 ! biopolymer methylation GO:0043414 62 41 0,000 0,15583083 0,17173498 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,15583083 0,17165273 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,15931573 0,17540746 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,15931573 0,17532353 ! cellular component disassembly GO:0022411 64 42 0,000 0,15931573 0,17523968 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,15931573 0,17515592 ! hexose transport GO:0008645 54 42 0,000 0,15931573 0,17507223 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,15931573 0,17498862 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,15931573 0,1749051 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,15931573 0,17482165 ! excretion GO:0007588 63 42 0,000 0,15931573 0,17473828 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,15931573 0,17465499 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,15931573 0,17457178 ! regulation of cell shape GO:0008360 78 42 0,000 0,15931573 0,17448866 ! neuromuscular process GO:0050905 79 43 0,000 0,16278644 0,17820506 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,16278644 0,17812028 ! vesicle organization GO:0016050 79 43 0,000 0,16278644 0,17803558 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,16278644 0,17795096 ! methylation GO:0032259 64 43 0,000 0,16278644 0,17786642 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,16624303 0,18155696 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,16624303 0,18147079 ! glycolysis GO:0006096 53 44 0,000 0,16624303 0,18138471 ! regulation of action potential GO:0001508 71 44 0,000 0,16624303 0,1812987 ! regulation of ion transport GO:0043269 57 44 0,000 0,16624303 0,18121278 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,16624303 0,18112694 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,16624303 0,18104118 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,16624303 0,1809555 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,16624303 0,1808699 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,16624303 0,18078438 ! regulation of translational initiation GO:0006446 64 45 0,000 0,16968554 0,1844408 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,16968554 0,18435368 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,16968554 0,18426664 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,17311403 0,18790103 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,17311403 0,18781239 ! cell redox homeostasis GO:0045454 63 46 0,000 0,17311403 0,18772384 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,17311403 0,18763538 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,17652856 0,19124621 ! viral infectious cycle GO:0019058 71 47 0,000 0,17652856 0,19115617 ! endocrine system development GO:0035270 83 47 0,000 0,17652856 0,19106621 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,17652856 0,19097634 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,17652856 0,19088655 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,17652856 0,19079685 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,17652856 0,19070723 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,17652856 0,1906177 ! chloride transport GO:0006821 67 48 0,000 0,17992919 0,19419857 ! response to temperature stimulus GO:0009266 62 48 0,000 0,17992919 0,19410748 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,17992919 0,19401648 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,17992919 0,19392556 ! gastrulation GO:0007369 73 48 0,000 0,17992919 0,19383473 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,17992919 0,19374398 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,17992919 0,19365332 ! nuclear export GO:0051168 69 48 0,000 0,17992919 0,19356274 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,17992919 0,19347225 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,17992919 0,19338184 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,18331597 0,19692981 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,18331597 0,19683788 ! sensory perception of smell GO:0007608 61 49 0,000 0,18331597 0,19674603 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,18331597 0,19665426 ! RNA elongation GO:0006354 62 49 0,000 0,18331597 0,19656258 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,18331597 0,19647098 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,18331597 0,19637948 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,18331597 0,19628805 ! regulation of actin filament length GO:0030832 72 50 0,000 0,18668896 0,1998067 ! ear development GO:0043583 72 50 0,000 0,18668896 0,19971377 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,18668896 0,19962092 ! membrane fusion GO:0006944 80 50 0,000 0,18668896 0,19952816 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,18668896 0,19943549 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,18668896 0,1993429 ! proton transport GO:0015992 75 50 0,000 0,18668896 0,19925039 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,18668896 0,19915798 ! positive regulation of secretion GO:0051047 71 51 0,000 0,1900482 0,2026476 ! hydrogen transport GO:0006818 77 51 0,000 0,1900482 0,20255369 ! muscle fiber development GO:0048747 74 51 0,000 0,1900482 0,20245987 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,1900482 0,20236614 ! adult behavior GO:0030534 80 51 0,000 0,1900482 0,2022725 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,1900482 0,20217894 ! transition metal ion transport GO:0000041 74 52 0,000 0,19339377 0,20564293 ! regulation of cellular component size GO:0032535 74 52 0,000 0,19339377 0,2055479 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,19339377 0,20545296 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,1967257 0,20889618 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,1967257 0,20879978 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,1967257 0,20870347 ! kidney development GO:0001822 90 53 0,000 0,1967257 0,20860725 ! single fertilization GO:0007338 59 53 0,000 0,1967257 0,20851111 ! cell projection assembly GO:0030031 76 53 0,000 0,1967257 0,20841507 ! amino acid transport GO:0006865 84 54 0,000 0,20004407 0,21183304 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,20004407 0,21173555 ! regulation of mitosis GO:0007088 84 54 0,000 0,20004407 0,21163816 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,20004407 0,21154085 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,20004407 0,21144364 ! DNA catabolic process GO:0006308 67 54 0,000 0,20004407 0,21134651 ! detection of external stimulus GO:0009581 66 54 0,000 0,20004407 0,21124947 ! exocytosis GO:0006887 74 55 0,000 0,20334891 0,21464089 ! mesoderm development GO:0007498 76 55 0,000 0,20334891 0,21454243 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,20334891 0,21444406 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,20334891 0,21434578 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,20664029 0,21771538 ! carbohydrate transport GO:0008643 74 57 0,000 0,20991826 0,22106777 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,20991826 0,22096659 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,20991826 0,22086551 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,20991826 0,22076452 ! camera-type eye development GO:0043010 88 57 0,000 0,20991826 0,22066362 ! secondary metabolic process GO:0019748 84 57 0,000 0,20991826 0,22056281 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,21318287 0,22389069 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,21318287 0,2237885 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,21318287 0,22368641 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,21643418 0,22699436 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,21643418 0,2268909 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,21967225 0,23018049 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,21967225 0,23007567 ! fertilization GO:0009566 68 60 0,000 0,21967225 0,22997094 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,21967225 0,22986632 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,22289711 0,23313477 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,22289711 0,2330288 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,22289711 0,23292292 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,22289711 0,23281715 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,22289711 0,23271146 ! extracellular matrix organization GO:0030198 103 61 0,000 0,22289711 0,23260588 ! neurotransmitter transport GO:0006836 81 62 0,000 0,22610883 0,23585048 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,22610883 0,23574357 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,22930746 0,23897017 ! appendage morphogenesis GO:0035107 93 64 0,000 0,23249306 0,24218027 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,23249306 0,24207064 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,23249306 0,2419611 ! hexose catabolic process GO:0019320 82 64 0,000 0,23249306 0,24185167 ! appendage development GO:0048736 94 65 0,000 0,23566567 0,24504115 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,23566567 0,24493043 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,23566567 0,2448198 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,23566567 0,24470927 ! activation of immune response GO:0002253 83 65 0,000 0,23566567 0,24459884 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,23882534 0,24776648 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,23882534 0,24765477 ! antigen processing and presentation GO:0019882 96 66 0,000 0,23882534 0,24754317 ! axon guidance GO:0007411 99 66 0,000 0,23882534 0,24743166 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,23882534 0,24732026 ! regulation of immune effector process GO:0002697 101 66 0,000 0,23882534 0,24720895 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,24197214 0,25035354 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,24197214 0,25024097 ! learning or memory GO:0007611 123 68 0,000 0,2451061 0,25336811 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,2451061 0,25325428 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,2451061 0,25314056 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,2451061 0,25302695 ! rhythmic process GO:0048511 105 68 0,000 0,2451061 0,25291343 ! inorganic anion transport GO:0015698 93 68 0,000 0,2451061 0,25280002 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,24822729 0,25590442 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,24822729 0,25578977 ! response to metal ion GO:0010038 103 70 0,000 0,25133575 0,25887695 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,25133575 0,25876107 ! humoral immune response GO:0006959 86 70 0,000 0,25133575 0,25864529 ! eye development GO:0001654 111 70 0,000 0,25133575 0,25852962 ! amine transport GO:0015837 101 70 0,000 0,25133575 0,25841405 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,25133575 0,25829858 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,25443154 0,26136335 ! muscle cell differentiation GO:0042692 104 71 0,000 0,25443154 0,26124667 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,25443154 0,26113009 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,2575147 0,26417654 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,2575147 0,26405876 ! regulation of blood pressure GO:0008217 107 73 0,000 0,26058529 0,26708831 ! tube morphogenesis GO:0035239 118 73 0,000 0,26058529 0,26696934 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,26364335 0,26998206 ! digestion GO:0007586 97 74 0,000 0,26364335 0,26986191 ! blood coagulation GO:0007596 116 75 0,000 0,26668895 0,27285791 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,26668895 0,27273658 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,26668895 0,27261537 ! amine biosynthetic process GO:0009309 97 76 0,000 0,26972212 0,27559345 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,26972212 0,27547108 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,27274291 0,27843262 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,27274291 0,2783091 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,27274291 0,27818568 ! cellular respiration GO:0045333 107 79 0,000 0,27874759 0,28418416 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,27874759 0,28405825 ! chromatin assembly GO:0031497 102 80 0,000 0,28173157 0,28697193 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,28173157 0,28684489 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,28173157 0,28671797 ! forebrain development GO:0030900 131 80 0,000 0,28173157 0,28659116 ! hemostasis GO:0007599 125 81 0,000 0,28470337 0,28948619 ! mRNA transport GO:0051028 121 81 0,000 0,28470337 0,28935827 ! regulation of neurological system process GO:0031644 122 81 0,000 0,28470337 0,28923046 ! vitamin metabolic process GO:0006766 103 81 0,000 0,28470337 0,28910276 ! detection of stimulus GO:0051606 108 82 0,000 0,28766305 0,29197927 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,29061065 0,29484098 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,29061065 0,29471098 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,29354623 0,29755677 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,29646982 0,30038792 ! rRNA metabolic process GO:0016072 107 85 0,000 0,29646982 0,30025565 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,29646982 0,3001235 ! regulation of membrane potential GO:0042391 128 85 0,000 0,29646982 0,29999146 ! nucleosome organization GO:0034728 114 87 0,000 0,30228126 0,30573742 ! cellular defense response GO:0006968 102 87 0,000 0,30228126 0,30560303 ! female pregnancy GO:0007565 130 87 0,000 0,30228126 0,30546876 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,30228126 0,3053346 ! establishment of RNA localization GO:0051236 128 88 0,000 0,3051692 0,3081164 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,3051692 0,3079812 ! regulation of T cell activation GO:0050863 128 89 0,000 0,30804535 0,31074751 ! hormone metabolic process GO:0042445 121 90 0,000 0,31090977 0,31349954 ! RNA localization GO:0006403 135 91 0,000 0,31376249 0,31623739 ! positive regulation of immune response GO:0050778 121 92 0,000 0,31660356 0,3189611 ! sulfur metabolic process GO:0006790 118 92 0,000 0,31660356 0,31882145 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,31943303 0,32152997 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,31943303 0,32138931 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,31943303 0,32124879 ! electron transport chain GO:0022900 123 94 0,000 0,32225095 0,32394108 ! response to oxidative stress GO:0006979 141 94 0,000 0,32225095 0,32379956 ! angiogenesis GO:0001525 149 95 0,000 0,32505737 0,32647683 ! carboxylic acid transport GO:0046942 147 95 0,000 0,32505737 0,32633433 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,32785232 0,32899666 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,32785232 0,32885318 ! protein maturation GO:0051604 129 96 0,000 0,32785232 0,32870982 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,33063586 0,3313562 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! extracellular structure organization GO:0043062 156 99 0,000 0,33616888 0,33675454 ! regulation of translation GO:0006417 151 100 0,000 0,33891846 0,3393611 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,33891846 0,33921343 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,33891846 0,33906588 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,33891846 0,33891846