pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6763-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 2,844E-06 6,541E-03 ! male meiosis GO:0007140 7 6 2,000 8,09E-06 9,304E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 8,494E-06 6,512E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 1,167E-05 6,708E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,24E-05 0,01030623 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,24E-05 8,589E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 3,000 2,388E-05 7,845E-03 ! cell cycle arrest GO:0007050 150 86 5,000 4,543E-05 0,01305974 ! response to X-ray GO:0010165 16 10 2,000 4,749E-05 0,01213516 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 4,749E-05 0,01092164 ! protein sumoylation GO:0016925 12 10 2,000 4,749E-05 9,929E-03 ! protein modification by small protein conjugation GO:0032446 140 90 5,000 5,87E-05 0,01125157 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 6,705E-05 0,01186225 ! negative regulation of kinase activity GO:0033673 100 58 4,000 7,293E-05 0,01198216 ! mammary gland development GO:0030879 57 31 3,000 8,099E-05 0,01241877 ! protein modification by small protein conjugation or removal GO:0070647 148 96 5,000 8,426E-05 0,01211303 ! response to gamma radiation GO:0010332 20 12 2,000 8,611E-05 0,01164953 ! negative regulation of transferase activity GO:0051348 105 61 4,000 9,301E-05 0,01188458 ! regulation of S phase GO:0033261 18 14 2,000 1,409E-04 0,01705743 ! centrosome cycle GO:0007098 16 15 2,000 1,752E-04 0,02014484 ! synapse organization GO:0050808 55 39 3,000 2,021E-04 0,02213774 ! glycerol metabolic process GO:0006071 20 17 2,000 2,589E-04 0,02707101 ! alditol metabolic process GO:0019400 24 20 2,000 4,27E-04 0,04270266 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 4,443E-04 0,04258308 ! cell aging GO:0007569 32 21 2,000 4,955E-04 0,04558385 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,491E-04 0,0485724 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 5,491E-04 0,04677342 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,491E-04 0,04510294 ! valine metabolic process GO:0006573 8 5 1,000 5,491E-04 0,04354767 ! polyol catabolic process GO:0046174 7 5 1,000 5,491E-04 0,04209608 GO:0019405|alditol catabolic process, ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 5,491E-04 0,04073814 ! centrosome duplication GO:0051298 5 5 1,000 5,491E-04 0,03946508 ! response to UV-C GO:0010225 6 5 1,000 5,491E-04 0,03826916 ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 5,491E-04 0,0371436 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 5,491E-04 0,03608235 ! apical protein localization GO:0045176 6 5 1,000 5,491E-04 0,03508007 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 1,000 5,491E-04 0,03413196 ! neural plate development GO:0001840 6 5 1,000 5,491E-04 0,03323375 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 5,491E-04 0,0323816 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! microtubule organizing center organization GO:0031023 28 22 2,000 5,706E-04 0,0328082 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 5,706E-04 0,032008 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 5,73E-04 0,03137589 ! negative regulation of DNA replication GO:0008156 35 23 2,000 6,526E-04 0,03490558 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 6,526E-04 0,03411227 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 8,181E-04 0,04181609 ! regulation of helicase activity GO:0051095 11 6 1,000 8,196E-04 0,04097869 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 8,196E-04 0,0401068 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 8,196E-04 0,03927125 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 8,196E-04 0,03846979 ! amyloid precursor protein catabolic process GO:0042987 9 6 1,000 8,196E-04 0,0377004 ! activation of MAPKKK activity GO:0000185 10 6 1,000 8,196E-04 0,03696117 ! thymic T cell selection GO:0045061 12 6 1,000 8,196E-04 0,03625038 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 8,196E-04 0,03556641 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 8,196E-04 0,03490777 ! ER overload response GO:0006983 7 6 1,000 8,196E-04 0,03427309 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 8,196E-04 0,03366107 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! anterograde axon cargo transport GO:0008089 8 6 1,000 8,196E-04 0,03307052 ! coenzyme A metabolic process GO:0015936 9 6 1,000 8,196E-04 0,03250034 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 8,196E-04 0,03194949 ! blastocyst growth GO:0001832 15 6 1,000 8,196E-04 0,031417 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 8,383E-04 0,03160758 GO:0045936|negative regulation of phosphate metabolic process, ! response to ionizing radiation GO:0010212 47 27 2,000 1,054E-03 0,03911823 ! regulation of homeostatic process GO:0032844 105 60 3,000 1,061E-03 0,0387512 ! glycerol-3-phosphate metabolic process GO:0006072 9 7 1,000 1,142E-03 0,0410324 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,142E-03 0,04040114 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,142E-03 0,039789 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,142E-03 0,03919513 ! positive regulation of isotype switching GO:0045830 15 7 1,000 1,142E-03 0,03861873 GO:0045911|positive regulation of DNA recombination, ! vesicle fusion GO:0006906 15 7 1,000 1,142E-03 0,03805904 ! asymmetric protein localization GO:0008105 8 7 1,000 1,142E-03 0,03751534 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,142E-03 0,03698696 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,142E-03 0,03647325 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,142E-03 0,03597362 ! B cell lineage commitment GO:0002326 17 7 1,000 1,142E-03 0,03548749 ! T cell lineage commitment GO:0002360 12 7 1,000 1,142E-03 0,03501432 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 1,142E-03 0,0345536 GO:0002714|positive regulation of B cell mediated immunity, ! response to tumor cell GO:0002347 12 7 1,000 1,142E-03 0,03410486 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 1,142E-03 0,03366761 ! ATP catabolic process GO:0006200 10 7 1,000 1,142E-03 0,03324144 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 1,142E-03 0,03282592 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 1,142E-03 0,03242067 ! regulation of caspase activity GO:0043281 97 65 3,000 1,432E-03 0,04016278 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,515E-03 0,04197897 ! succinate metabolic process GO:0006105 14 8 1,000 1,515E-03 0,04147922 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,515E-03 0,04099123 ! keratinocyte proliferation GO:0043616 12 8 1,000 1,515E-03 0,04051459 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,515E-03 0,04004891 ! amyloid precursor protein metabolic process GO:0042982 12 8 1,000 1,515E-03 0,0395938 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 1,515E-03 0,03914893 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 1,000 1,515E-03 0,03871394 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 1,000 1,515E-03 0,03828851 ! multicellular organism growth GO:0035264 14 8 1,000 1,515E-03 0,03787234 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,515E-03 0,03746511 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 1,515E-03 0,03706654 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,515E-03 0,03667637 ! regulation of embryonic development GO:0045995 16 8 1,000 1,515E-03 0,03629432 ! axon guidance GO:0007411 99 66 3,000 1,516E-03 0,03593505 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 1,602E-03 0,03760961 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 1,74E-03 0,04042359 ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 1,904E-03 0,04378182 ! cytokinesis GO:0000910 52 33 2,000 1,904E-03 0,04334834 ! T cell selection GO:0045058 18 9 1,000 1,938E-03 0,04370385 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,938E-03 0,04327954 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 14 9 1,000 1,938E-03 0,04286339 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 1,000 1,938E-03 0,04245517 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 1,938E-03 0,04205465 GO:0002820|negative regulation of adaptive immune response, ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,938E-03 0,04166161 ! oocyte differentiation GO:0009994 12 9 1,000 1,938E-03 0,04127586 GO:0048599|oocyte development, ! establishment of cell polarity GO:0030010 12 9 1,000 1,938E-03 0,04089718 ! polyol metabolic process GO:0019751 44 34 2,000 2,076E-03 0,04341604 ! regulation of peptidase activity GO:0052547 106 72 3,000 2,09E-03 0,04330516 ! mitochondrion organization GO:0007005 104 73 3,000 2,198E-03 0,04514633 ! Notch signaling pathway GO:0007219 56 35 2,000 2,259E-03 0,04597432 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 2,311E-03 0,04662018 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,411E-03 0,04821684 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,411E-03 0,04780118 ! regulation of B cell differentiation GO:0045577 16 10 1,000 2,411E-03 0,04739262 ! purine ribonucleotide catabolic process GO:0009154 14 10 1,000 2,411E-03 0,04699099 ! DNA methylation GO:0006306 15 10 1,000 2,411E-03 0,04659611 GO:0006305|DNA alkylation, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 2,411E-03 0,0462078 ! negative regulation of immune effector process GO:0002698 16 10 1,000 2,411E-03 0,04582592 ! gland development GO:0048732 148 77 3,000 2,671E-03 0,05036026 ! protein ubiquitination GO:0016567 125 77 3,000 2,671E-03 0,04995083 ! regulation of T cell proliferation GO:0042129 58 38 2,000 2,864E-03 0,05312537 ! pigmentation GO:0043473 74 38 2,000 2,864E-03 0,05270037 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 2,932E-03 0,05352346 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 2,932E-03 0,05310201 GO:0000725|recombinational repair, ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,932E-03 0,05268716 ! T cell proliferation GO:0042098 20 11 1,000 2,932E-03 0,05227873 ! negative regulation of proteolysis GO:0045861 16 11 1,000 2,932E-03 0,05187658 ! regulation of mRNA processing GO:0050684 18 11 1,000 2,932E-03 0,05148058 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 2,932E-03 0,05109057 ! ribonucleotide catabolic process GO:0009261 16 11 1,000 2,932E-03 0,05070643 ! cellular carbohydrate catabolic process GO:0044275 13 11 1,000 2,932E-03 0,05032803 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,932E-03 0,04995523 ! membrane protein proteolysis GO:0033619 18 11 1,000 2,932E-03 0,04958791 GO:0006509|membrane protein ectodomain proteolysis, ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 2,932E-03 0,04922596 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 2,932E-03 0,04886925 ! nitric oxide metabolic process GO:0046209 14 11 1,000 2,932E-03 0,04851767 GO:0006809|nitric oxide biosynthetic process, ! regulation of isotype switching GO:0045191 19 11 1,000 2,932E-03 0,04817111 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,932E-03 0,04782947 GO:0042130|negative regulation of T cell proliferation, ! lysogeny GO:0030069 18 11 1,000 2,932E-03 0,04749265 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 1,000 2,932E-03 0,04716053 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,086E-03 0,04929005 ! detection of stimulus involved in sensory perception GO:0050906 50 40 2,000 3,318E-03 0,05263187 ! T cell differentiation GO:0030217 65 40 2,000 3,318E-03 0,05227138 ! double-strand break repair GO:0006302 67 40 2,000 3,318E-03 0,05191579 ! JAK-STAT cascade GO:0007259 53 40 2,000 3,318E-03 0,05156501 ! positive regulation of cell growth GO:0030307 16 12 1,000 3,501E-03 0,05404791 ! glycoprotein catabolic process GO:0006516 19 12 1,000 3,501E-03 0,05368759 ! regulation of T cell differentiation GO:0045580 59 41 2,000 3,561E-03 0,05423476 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 3,818E-03 0,05776542 ! activation of caspase activity GO:0006919 65 43 2,000 4,078E-03 0,06129628 ! organelle fusion GO:0048284 28 13 1,000 4,118E-03 0,06149865 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 4,118E-03 0,06110188 ! bone mineralization GO:0030282 15 13 1,000 4,118E-03 0,06071021 ! regulation of cellular pH GO:0030641 20 13 1,000 4,118E-03 0,06032352 ! cellular pigmentation GO:0033059 24 13 1,000 4,118E-03 0,05994172 ! neuromuscular synaptic transmission GO:0007274 20 13 1,000 4,118E-03 0,05956473 ! detection of abiotic stimulus GO:0009582 58 44 2,000 4,352E-03 0,06256255 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 4,352E-03 0,06217397 ! heterophilic cell adhesion GO:0007157 29 14 1,000 4,781E-03 0,06787187 ! activation of MAPKK activity GO:0000186 21 14 1,000 4,781E-03 0,06745547 ! cellular response to starvation GO:0009267 21 14 1,000 4,781E-03 0,06704416 ! negative regulation of caspase activity GO:0043154 20 14 1,000 4,781E-03 0,06663783 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 4,781E-03 0,0662364 ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,781E-03 0,06583977 ! intermediate filament-based process GO:0045103 24 14 1,000 4,781E-03 0,06544787 ! axon cargo transport GO:0008088 27 14 1,000 4,781E-03 0,0650606 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,781E-03 0,0646779 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 4,781E-03 0,06429966 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 4,781E-03 0,06392583 ! response to UV GO:0009411 75 46 2,000 4,934E-03 0,06560298 ! response to estrogen stimulus GO:0043627 74 47 2,000 5,242E-03 0,069296 ! negative regulation of immune system process GO:0002683 73 47 2,000 5,242E-03 0,06890003 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 5,242E-03 0,06850855 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of cell size GO:0045793 20 15 1,000 5,489E-03 0,07132674 ! skin development GO:0043588 25 15 1,000 5,489E-03 0,07092603 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,489E-03 0,0705298 ! regulation of survival gene product expression GO:0045884 20 15 1,000 5,489E-03 0,07013797 ! DNA integration GO:0015074 22 15 1,000 5,489E-03 0,06975046 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 5,489E-03 0,06936722 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 5,489E-03 0,06898816 ! biomineral formation GO:0031214 18 15 1,000 5,489E-03 0,06861323 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 5,489E-03 0,06824234 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,489E-03 0,06787545 ! defense response to virus GO:0051607 27 15 1,000 5,489E-03 0,06751248 ! positive regulation of caspase activity GO:0043280 72 48 2,000 5,562E-03 0,06804116 GO:0010952|positive regulation of peptidase activity, ! regulation of actin polymerization or depolymerization GO:0008064 68 48 2,000 5,562E-03 0,06768115 ! regulation of DNA replication GO:0006275 75 48 2,000 5,562E-03 0,06732494 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 5,562E-03 0,06697245 ! in utero embryonic development GO:0001701 147 96 3,000 5,881E-03 0,07045036 ! response to light stimulus GO:0009416 153 96 3,000 5,881E-03 0,07008533 ! regulation of actin filament length GO:0030832 72 50 2,000 6,234E-03 0,07391413 ! positive regulation of growth GO:0045927 67 50 2,000 6,234E-03 0,07353509 ! negative regulation of immune response GO:0050777 28 16 1,000 6,243E-03 0,07325475 ! oogenesis GO:0048477 23 16 1,000 6,243E-03 0,07288289 ! neural crest cell migration GO:0001755 24 16 1,000 6,243E-03 0,0725148 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 6,243E-03 0,0721504 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 1,000 6,243E-03 0,07178965 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 6,243E-03 0,07143249 ! extracellular structure organization GO:0043062 156 99 3,000 6,551E-03 0,07459107 ! regulation of protein catabolic process GO:0042176 77 51 2,000 6,588E-03 0,07464625 ! regulation of cellular component size GO:0032535 74 52 2,000 6,954E-03 0,07840213 ! aging GO:0007568 79 52 2,000 6,954E-03 0,07801968 ! nucleotide-excision repair GO:0006289 64 52 2,000 6,954E-03 0,07764094 ! positive regulation of cell killing GO:0031343 24 17 1,000 7,04E-03 0,07822663 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 1,000 7,04E-03 0,07785054 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 7,04E-03 0,07747805 ! actin polymerization or depolymerization GO:0008154 31 17 1,000 7,04E-03 0,07710911 ! neuromuscular junction development GO:0007528 23 17 1,000 7,04E-03 0,07674366 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,04E-03 0,07638166 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 7,04E-03 0,07602306 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of intracellular transport GO:0032387 29 17 1,000 7,04E-03 0,07566781 ! synaptogenesis GO:0007416 24 17 1,000 7,04E-03 0,07531587 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 7,04E-03 0,07496719 ! detection of external stimulus GO:0009581 66 54 2,000 7,721E-03 0,0818321 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 7,882E-03 0,08315679 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 7,882E-03 0,08277708 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,882E-03 0,08240082 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 7,882E-03 0,08202797 ! purine nucleotide catabolic process GO:0006195 26 18 1,000 7,882E-03 0,08165847 ! negative regulation of T cell activation GO:0050868 25 18 1,000 7,882E-03 0,08129229 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 7,882E-03 0,08092938 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 8,766E-03 0,08960956 ! response to alkaloid GO:0043279 32 19 1,000 8,766E-03 0,08921306 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 8,766E-03 0,08882005 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 8,766E-03 0,08843049 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 8,766E-03 0,08804433 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 8,766E-03 0,08766153 ! apoptotic nuclear changes GO:0030262 24 19 1,000 8,766E-03 0,08728204 ! response to starvation GO:0042594 30 19 1,000 8,766E-03 0,08690583 ! sarcomere organization GO:0045214 23 19 1,000 8,766E-03 0,08653284 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 8,766E-03 0,08616304 ! microtubule-based transport GO:0010970 37 20 1,000 9,693E-03 0,09486494 ! DNA modification GO:0006304 28 20 1,000 9,693E-03 0,09446297 ! positive regulation of B cell activation GO:0050871 31 20 1,000 9,693E-03 0,0940644 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 9,693E-03 0,09366917 ! activation of MAPK activity GO:0000187 84 59 2,000 9,849E-03 0,09478114 ! actin filament organization GO:0007015 95 59 2,000 9,849E-03 0,09438622 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 2,000 0,0103115 0,0984085 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01066085 0,10132216 ! regulation of cell killing GO:0031341 34 21 1,000 0,01066085 0,1009052 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01066085 0,10049165 ! gluconeogenesis GO:0006094 25 21 1,000 0,01066085 0,10008148 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01066085 0,09967465 ! phototransduction GO:0007602 25 21 1,000 0,01066085 0,09927111 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01066085 0,09887082 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01066085 0,09847375 ! purine ribonucleoside metabolic process GO:0046128 28 21 1,000 0,01066085 0,09807985 GO:0042278|purine nucleoside metabolic process, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01066085 0,0976891 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01066085 0,09730144 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01066085 0,09691685 ! immunoglobulin production GO:0002377 33 21 1,000 0,01066085 0,09653529 GO:0002440|production of molecular mediator of immune response, ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 0,01066085 0,09615672 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01066085 0,09578111 ! meiosis GO:0007126 96 61 2,000 0,01078644 0,0965323 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01078644 0,09615814 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 0,01078644 0,09578688 ! negative regulation of cell growth GO:0030308 106 62 2,000 0,01127386 0,09973032 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 0,01127386 0,09934821 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01127386 0,09896902 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01166988 0,102056 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01166988 0,10166942 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 0,01166988 0,10128576 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! blastocyst development GO:0001824 37 22 1,000 0,01166988 0,10090499 ! protein tetramerization GO:0051262 39 22 1,000 0,01166988 0,10052707 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01166988 0,10015197 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01166988 0,09977966 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01166988 0,0994101 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,01177384 0,09992555 ! negative regulation of cell size GO:0045792 108 64 2,000 0,01228641 0,10389243 ! regulation of actin cytoskeleton organization GO:0032956 97 64 2,000 0,01228641 0,10351187 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01271915 0,10676657 ! neuron fate commitment GO:0048663 32 23 1,000 0,01271915 0,10637833 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01271915 0,1059929 ! myelination GO:0042552 35 23 1,000 0,01271915 0,10561025 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01271915 0,10523036 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01271915 0,10485319 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01271915 0,10447872 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01271915 0,1041069 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01271915 0,10373773 ! group transfer coenzyme metabolic process GO:0006752 28 23 1,000 0,01271915 0,10337117 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01271915 0,10300718 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 0,01281163 0,10339208 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01281163 0,10303057 ! regulation of actin filament-based process GO:0032970 99 66 2,000 0,01334954 0,10698236 ! initiation of viral infection GO:0019059 42 24 1,000 0,013808 0,11027225 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,013808 0,10989068 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 1,000 0,013808 0,10951175 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,013808 0,10913542 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,013808 0,10876167 ! neural crest cell development GO:0014032 39 24 1,000 0,013808 0,10839047 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,013808 0,10802179 ! primary neural tube formation GO:0014020 35 24 1,000 0,013808 0,10765562 ! negative regulation of cell development GO:0010721 56 24 1,000 0,013808 0,10729192 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,013808 0,10693067 ! base-excision repair GO:0006284 31 24 1,000 0,013808 0,10657184 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,013808 0,10621541 GO:0002708|positive regulation of lymphocyte mediated immunity, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,0149358 0,11450784 ! iron ion homeostasis GO:0055072 39 25 1,000 0,0149358 0,11412741 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,0149358 0,11374951 ! response to estradiol stimulus GO:0032355 34 25 1,000 0,0149358 0,11337409 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,0149358 0,11300115 ! detection of light stimulus GO:0009583 30 25 1,000 0,0149358 0,11263066 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,0149358 0,11226258 ! leukocyte proliferation GO:0070661 39 25 1,000 0,0149358 0,11189691 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,0149358 0,11153361 ! activation of protein kinase activity GO:0032147 102 69 2,000 0,01503981 0,11194683 ! response to drug GO:0042493 108 69 2,000 0,01503981 0,11158571 ! positive regulation of ligase activity GO:0051351 99 69 2,000 0,01503981 0,11122692 ! regulation of catabolic process GO:0009894 106 70 2,000 0,01562887 0,11521284 ! regulation of pH GO:0006885 36 26 1,000 0,01610192 0,11832079 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01610192 0,11794397 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,0162308 0,11851059 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,0162308 0,11813556 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,01730571 0,12556194 ! myofibril assembly GO:0030239 36 27 1,000 0,01730571 0,12516709 GO:0055002|striated muscle cell development, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01730571 0,12477471 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01730571 0,12438479 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01730571 0,1239973 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,01747335 0,12480968 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01854657 0,13206533 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,01854657 0,13165772 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01854657 0,13125262 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,01854657 0,13085 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01854657 0,13044985 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01854657 0,13005214 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01854657 0,12965684 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01854657 0,12926394 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01854657 0,12887342 ! negative regulation of growth GO:0045926 123 75 2,000 0,01876766 0,1300169 ! regulation of ligase activity GO:0051340 114 75 2,000 0,01876766 0,12962646 ! muscle cell development GO:0055001 38 29 1,000 0,01982387 0,13651166 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,01982387 0,13610416 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,01982387 0,13569909 ! tissue homeostasis GO:0001894 42 29 1,000 0,01982387 0,13529642 GO:0048871|multicellular organismal homeostasis, ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02113701 0,14383172 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,02113701 0,14340744 ! response to heat GO:0009408 41 30 1,000 0,02113701 0,14298565 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,02113701 0,14256634 ! T cell activation GO:0042110 134 79 2,000 0,02151198 0,14467118 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,02223055 0,1490678 GO:0010498|proteasomal protein catabolic process, ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02248539 0,15033837 ! glial cell differentiation GO:0010001 55 31 1,000 0,02248539 0,14990261 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,02248539 0,14946936 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,02248539 0,14903861 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,02248539 0,14861034 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02248539 0,14818452 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02248539 0,14776114 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02296212 0,15046404 ! detection of stimulus GO:0051606 108 82 2,000 0,0237067 0,15490173 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02386842 0,15551661 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02386842 0,1550773 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02386842 0,15464046 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,02386842 0,15420608 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,02386842 0,15377413 ! regulation of cell adhesion GO:0030155 159 83 2,000 0,02446428 0,15717274 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02523485 0,16167175 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02528551 0,16154629 ! ear morphogenesis GO:0042471 42 33 1,000 0,02528551 0,1610988 ! actomyosin structure organization GO:0031032 43 33 1,000 0,02528551 0,16065377 ! nucleus organization GO:0006997 49 33 1,000 0,02528551 0,1602112 ! female gonad development GO:0008585 49 33 1,000 0,02528551 0,15977106 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,02528551 0,15933333 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02528551 0,15889799 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02673607 0,16755578 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 0,02673607 0,16710047 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02673607 0,16664762 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02673607 0,16619722 ! female gamete generation GO:0007292 43 34 1,000 0,02673607 0,16574925 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,02673607 0,16530369 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 0,02681495 0,16534687 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,02762445 0,16988298 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02821955 0,1730799 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,02821955 0,17261958 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02821955 0,17216171 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 1,000 0,02821955 0,17170625 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 1,000 0,02821955 0,1712532 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,02821955 0,17080254 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02821955 0,17035424 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! interphase GO:0051325 159 88 2,000 0,0284469 0,17127716 ! protein processing GO:0016485 114 88 2,000 0,0284469 0,17082996 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,02928229 0,17538871 ! regulation of T cell activation GO:0050863 128 89 2,000 0,02928229 0,17493315 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,02973536 0,17717964 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,02973536 0,17672181 ! neural tube development GO:0021915 50 36 1,000 0,02973536 0,17626634 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02973536 0,17581321 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,02973536 0,17536241 ! leukocyte differentiation GO:0002521 143 90 2,000 0,03013059 0,17723876 ! ATP metabolic process GO:0046034 137 91 2,000 0,03099178 0,18183955 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,03128296 0,18308094 ! learning GO:0007612 67 37 1,000 0,03128296 0,18261627 ! ion transmembrane transport GO:0034220 56 37 1,000 0,03128296 0,18215395 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 0,03128296 0,18169396 ! cell fate commitment GO:0045165 141 92 2,000 0,03186585 0,18461325 ! DNA recombination GO:0006310 146 92 2,000 0,03186585 0,18414939 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,03275277 0,1888004 ! gliogenesis GO:0042063 71 38 1,000 0,03286178 0,18895526 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,03286178 0,18848405 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,03286178 0,18801518 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03286178 0,18754864 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,03286178 0,18708441 ! response to oxidative stress GO:0006979 141 94 2,000 0,0336525 0,19111297 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03447129 0,19528069 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03447129 0,19480088 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,03447129 0,19432343 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,03447129 0,19384831 ! developmental growth GO:0048589 62 39 1,000 0,03447129 0,19337551 ! protein maturation GO:0051604 129 96 2,000 0,03549032 0,19860761 ! response to calcium ion GO:0051592 58 40 1,000 0,03611093 0,20159013 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03611093 0,20110202 ! B cell differentiation GO:0030183 62 40 1,000 0,03611093 0,20061627 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03611093 0,20013285 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03611093 0,19965176 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 0,03642834 0,20092367 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03691395 0,20311502 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03691395 0,20263026 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03691395 0,20214781 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03691395 0,20166765 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03691395 0,20118976 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03691395 0,20071413 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03691395 0,20024075 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03691395 0,1997696 ! sleep GO:0030431 11 5 0,000 0,03691395 0,19930065 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03691395 0,19883391 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03691395 0,19836934 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03691395 0,19790694 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03691395 0,19744669 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03691395 0,19698858 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03691395 0,19653259 ! tongue development GO:0043586 6 5 0,000 0,03691395 0,1960787 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03691395 0,19562691 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03691395 0,19517719 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03691395 0,19472954 ! cobalt ion transport GO:0006824 9 5 0,000 0,03691395 0,19428393 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03691395 0,19384036 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03691395 0,19339881 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03691395 0,19295927 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03691395 0,19252172 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03691395 0,19208615 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03691395 0,19165255 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03691395 0,1912209 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03691395 0,19079119 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03691395 0,19036341 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03691395 0,18993754 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03691395 0,18951357 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03691395 0,18909149 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03691395 0,18867129 ! malate metabolic process GO:0006108 7 5 0,000 0,03691395 0,18825295 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03691395 0,18783646 ! behavioral response to pain GO:0048266 7 5 0,000 0,03691395 0,18742181 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03691395 0,18700898 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03691395 0,18659798 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03691395 0,18618877 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03691395 0,18578135 ! mating behavior GO:0007617 6 5 0,000 0,03691395 0,18537572 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03691395 0,18497185 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03691395 0,18456974 ! rhythmic behavior GO:0007622 12 5 0,000 0,03691395 0,18416937 ! copulation GO:0007620 7 5 0,000 0,03691395 0,18377073 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03691395 0,18337382 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03691395 0,18297862 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03691395 0,18258512 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03691395 0,1821933 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03691395 0,18180317 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03691395 0,1814147 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03691395 0,18102789 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03691395 0,18064272 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03691395 0,18025919 ! response to protozoan GO:0001562 9 5 0,000 0,03691395 0,17987729 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03691395 0,179497 ! lymph vessel development GO:0001945 7 5 0,000 0,03691395 0,17911831 ! endochondral ossification GO:0001958 12 5 0,000 0,03691395 0,17874122 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03691395 0,17836571 ! parathyroid gland development GO:0060017 8 5 0,000 0,03691395 0,17799178 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03691395 0,17761941 ! anagen GO:0042640 6 5 0,000 0,03691395 0,1772486 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03691395 0,17687933 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03691395 0,1765116 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03691395 0,17614539 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03691395 0,1757807 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03691395 0,17541752 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03691395 0,17505583 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03691395 0,17469564 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03691395 0,17433692 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03691395 0,17397967 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03691395 0,17362388 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03691395 0,17326955 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03691395 0,17291666 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03691395 0,1725652 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03691395 0,17221517 ! ovulation GO:0030728 6 5 0,000 0,03691395 0,17186656 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03691395 0,17151935 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03691395 0,17117355 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03691395 0,17082913 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03691395 0,1704861 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03691395 0,17014445 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03691395 0,16980416 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03691395 0,16946523 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03691395 0,16912765 ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03691395 0,16879141 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03691395 0,16845651 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03691395 0,16812293 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03691395 0,16779067 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03691395 0,16745972 ! urea metabolic process GO:0019627 6 5 0,000 0,03691395 0,16713008 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03691395 0,16680173 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03691395 0,16647466 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03691395 0,16614888 ! neutrophil activation GO:0042119 5 5 0,000 0,03691395 0,16582437 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03691395 0,16550113 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03691395 0,16517914 ! response to food GO:0032094 5 5 0,000 0,03691395 0,16485841 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03691395 0,16453891 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03691395 0,16422066 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03691395 0,16390363 ! forebrain neuron development GO:0021884 7 5 0,000 0,03691395 0,16358782 ! melanosome organization GO:0032438 7 5 0,000 0,03691395 0,16327323 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03691395 0,16295984 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03691395 0,16264766 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03691395 0,16233667 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03691395 0,16202687 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03691395 0,16171825 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03691395 0,1614108 ! nucleoside transport GO:0015858 6 5 0,000 0,03691395 0,16110451 ! nucleoside salvage GO:0043174 7 5 0,000 0,03691395 0,16079939 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03691395 0,16049542 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03691395 0,1601926 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03691395 0,15989092 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03691395 0,15959037 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03691395 0,15929095 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03691395 0,15899266 ! depyrimidination GO:0045008 8 5 0,000 0,03691395 0,15869547 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03691395 0,1583994 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03691395 0,15810443 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03691395 0,15781056 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03691395 0,15751777 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03691395 0,15722607 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03691395 0,15693545 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03691395 0,1566459 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03691395 0,15635742 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03691395 0,15607 ! monocyte differentiation GO:0030224 8 5 0,000 0,03691395 0,15578363 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03691395 0,15549831 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03691395 0,15521404 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03691395 0,1549308 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03691395 0,1546486 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03691395 0,15436742 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03691395 0,15408726 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03691395 0,15380811 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03691395 0,15352998 ! melanosome transport GO:0032402 8 5 0,000 0,03691395 0,15325285 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03691395 0,15297672 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03691395 0,15270158 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03691395 0,15242743 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03691395 0,15215426 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03691395 0,15188207 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03691395 0,15161085 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03691395 0,1513406 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03691395 0,15107131 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03691395 0,15080298 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03691395 0,1505356 ! neural tube patterning GO:0021532 6 5 0,000 0,03691395 0,15026917 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03691395 0,15000367 ! histone demethylation GO:0016577 9 5 0,000 0,03691395 0,14973912 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03691395 0,14947549 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03691395 0,14921279 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03691395 0,14895102 ! enteric nervous system development GO:0048484 8 5 0,000 0,03691395 0,14869016 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03691395 0,14843021 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03691395 0,14817117 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03691395 0,14791303 ! transcription termination GO:0006353 8 5 0,000 0,03691395 0,14765579 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03691395 0,14739944 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03691395 0,14714398 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03691395 0,14688941 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03691395 0,14663571 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03691395 0,14638289 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03691395 0,14613094 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03691395 0,14587986 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03691395 0,14562964 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03691395 0,14538027 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03691395 0,14513176 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03691395 0,14488409 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03691395 0,14463727 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03691395 0,14439129 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03691395 0,14414614 ! glial cell migration GO:0008347 10 5 0,000 0,03691395 0,14390183 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03691395 0,14365834 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03691395 0,14341567 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03691395 0,14317383 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03691395 0,14293279 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03691395 0,14269257 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03691395 0,14245315 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03691395 0,14221454 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03691395 0,14197672 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03691395 0,1417397 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03691395 0,14150346 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03691395 0,14126802 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03691395 0,14103335 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03691395 0,14079947 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03691395 0,14056636 ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03691395 0,14033401 ! spindle assembly GO:0051225 5 5 0,000 0,03691395 0,14010244 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03691395 0,13987163 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03691395 0,13964158 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03691395 0,13941228 ! organ regeneration GO:0031100 7 5 0,000 0,03691395 0,13918374 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03691395 0,13895594 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03691395 0,13872889 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03691395 0,13850258 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03691395 0,138277 GO:0055081|anion homeostasis, ! striated muscle contraction GO:0006941 62 41 1,000 0,03778017 0,14129171 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,03778017 0,14106234 ! biopolymer methylation GO:0043414 62 41 1,000 0,03778017 0,14083371 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,03834243 0,14269835 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 2,000 0,03931842 0,1460943 ! mitochondrial transport GO:0006839 60 42 1,000 0,0394785 0,14645248 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,0394785 0,14621665 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,0394785 0,14598158 ! cellular component disassembly GO:0022411 64 42 1,000 0,0394785 0,14574726 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,0394785 0,14551369 ! regulation of cell shape GO:0008360 78 42 1,000 0,0394785 0,14528086 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,04120537 0,15139354 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,04120537 0,15115208 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04120537 0,15091139 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,04120537 0,15067147 ! vesicle organization GO:0016050 79 43 1,000 0,04120537 0,15043231 ! response to insulin stimulus GO:0032868 63 43 1,000 0,04120537 0,15019391 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,04120537 0,14995626 ! methylation GO:0032259 64 43 1,000 0,04120537 0,14971936 ! regulation of action potential GO:0001508 71 44 1,000 0,04296029 0,15584962 ! tRNA transcription GO:0009304 11 6 0,000 0,04413282 0,15985117 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04413282 0,15959983 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04413282 0,15934928 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04413282 0,15909951 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04413282 0,15885053 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04413282 0,15860233 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04413282 0,1583549 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04413282 0,15810824 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04413282 0,15786235 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04413282 0,15761722 ! prostate gland development GO:0030850 9 6 0,000 0,04413282 0,15737285 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04413282 0,15712924 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04413282 0,15688638 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04413282 0,15664428 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04413282 0,15640291 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04413282 0,15616229 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04413282 0,15592241 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04413282 0,15568327 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,04413282 0,15544486 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04413282 0,15520717 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04413282 0,15497021 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04413282 0,15473398 ! signal peptide processing GO:0006465 8 6 0,000 0,04413282 0,15449846 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04413282 0,15426366 ! mRNA stabilization GO:0048255 15 6 0,000 0,04413282 0,15402958 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04413282 0,1537962 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04413282 0,15356353 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04413282 0,15333156 ! opsonization GO:0008228 8 6 0,000 0,04413282 0,15310029 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04413282 0,15286971 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04413282 0,15263984 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04413282 0,15241065 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04413282 0,15218214 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04413282 0,15195433 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04413282 0,15172719 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04413282 0,15150073 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04413282 0,15127495 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04413282 0,15104984 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04413282 0,15082539 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04413282 0,15060162 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04413282 0,1503785 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04413282 0,15015605 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04413282 0,14993425 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04413282 0,14971311 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04413282 0,14949262 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04413282 0,14927278 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04413282 0,14905358 ! protein lipoylation GO:0009249 10 6 0,000 0,04413282 0,14883503 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04413282 0,14861712 ! pigment granule organization GO:0048753 11 6 0,000 0,04413282 0,14839984 ! drug transport GO:0015893 6 6 0,000 0,04413282 0,1481832 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04413282 0,14796719 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04413282 0,14775181 ! histidine metabolic process GO:0006547 6 6 0,000 0,04413282 0,14753705 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04413282 0,14732292 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04413282 0,14710941 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04413282 0,14689651 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04413282 0,14668423 ! adenohypophysis development GO:0021984 10 6 0,000 0,04413282 0,14647257 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04413282 0,14626151 ! hyperosmotic response GO:0006972 8 6 0,000 0,04413282 0,14605107 ! microtubule nucleation GO:0007020 10 6 0,000 0,04413282 0,14584122 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04413282 0,14563198 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04413282 0,14542334 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04413282 0,14521529 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04413282 0,14500784 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04413282 0,14480099 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04413282 0,14459472 ! response to dietary excess GO:0002021 7 6 0,000 0,04413282 0,14438903 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04413282 0,14418394 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04413282 0,14397942 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04413282 0,14377548 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04413282 0,14357212 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04413282 0,14336934 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04413282 0,14316712 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04413282 0,14296548 ! neuron apoptosis GO:0051402 8 6 0,000 0,04413282 0,1427644 ! organic alcohol transport GO:0015850 9 6 0,000 0,04413282 0,14256389 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04413282 0,14236394 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04413282 0,14216455 ! male sex determination GO:0030238 9 6 0,000 0,04413282 0,14196572 ! carnitine transport GO:0015879 8 6 0,000 0,04413282 0,14176744 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04413282 0,14156972 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04413282 0,14137255 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04413282 0,14117593 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04413282 0,14097985 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04413282 0,14078431 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04413282 0,14058932 ! parturition GO:0007567 12 6 0,000 0,04413282 0,14039487 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04413282 0,14020095 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04413282 0,14000757 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04413282 0,13981473 ! spindle checkpoint GO:0031577 14 6 0,000 0,04413282 0,13962241 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04413282 0,13943062 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04413282 0,13923936 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04413282 0,13904862 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04413282 0,1388584 ! macrophage differentiation GO:0030225 10 6 0,000 0,04413282 0,1386687 ! astrocyte development GO:0014002 14 6 0,000 0,04413282 0,13847952 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04413282 0,13829086 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04413282 0,13810271 ! interaction with symbiont GO:0051702 8 6 0,000 0,04413282 0,13791507 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04413282 0,13772794 ! eating behavior GO:0042755 6 6 0,000 0,04413282 0,13754132 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04413282 0,1373552 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04413282 0,13716958 ! response to copper ion GO:0046688 9 6 0,000 0,04413282 0,13698447 ! DNA topological change GO:0006265 8 6 0,000 0,04413282 0,13679985 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04413282 0,13661573 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04413282 0,13643211 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04413282 0,13624898 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04413282 0,13606634 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04413282 0,13588419 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04413282 0,13570253 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04413282 0,13552135 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04413282 0,13534065 ! gas homeostasis GO:0033483 11 6 0,000 0,04413282 0,13516044 ! hair follicle maturation GO:0048820 7 6 0,000 0,04413282 0,13498071 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04413282 0,13480145 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04413282 0,13462267 ! Schwann cell development GO:0014044 14 6 0,000 0,04413282 0,13444436 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04413282 0,13426652 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04413282 0,13408916 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04413282 0,13391226 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04413282 0,13373582 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04413282 0,13355986 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04413282 0,13338435 ! histone ubiquitination GO:0016574 7 6 0,000 0,04413282 0,13320931 ! regulation of meiosis GO:0040020 10 6 0,000 0,04413282 0,13303472 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04413282 0,13286059 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04413282 0,13268692 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04413282 0,1325137 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04413282 0,13234093 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04413282 0,13216861 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04413282 0,13199674 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04413282 0,13182531 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04413282 0,13165433 ! receptor internalization GO:0031623 9 6 0,000 0,04413282 0,1314838 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04413282 0,1313137 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04413282 0,13114404 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04413282 0,13097483 ! protein deubiquitination GO:0016579 8 6 0,000 0,04413282 0,13080604 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04413282 0,1306377 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04413282 0,13046978 ! axonal fasciculation GO:0007413 9 6 0,000 0,04413282 0,1303023 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04413282 0,13013524 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04413282 0,12996862 ! midbrain development GO:0030901 6 6 0,000 0,04413282 0,12980242 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04413282 0,12963664 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04413282 0,12947129 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04413282 0,12930636 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04413282 0,12914185 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04413282 0,12897775 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04413282 0,12881407 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04413282 0,12865081 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04413282 0,12848796 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04413282 0,12832553 ! adult feeding behavior GO:0008343 6 6 0,000 0,04413282 0,1281635 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04413282 0,12800188 ! pigment granule transport GO:0051904 12 6 0,000 0,04413282 0,12784067 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04413282 0,12767986 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04413282 0,12751946 ! catecholamine transport GO:0051937 7 6 0,000 0,04413282 0,12735946 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04413282 0,12719986 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04413282 0,12704066 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04413282 0,12688186 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04413282 0,12672346 ! protein prenylation GO:0018342 10 6 0,000 0,04413282 0,12656545 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04413282 0,12640783 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04413282 0,12625061 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04413282 0,12609378 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04413282 0,12593733 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04413282 0,12578128 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,04474273 0,12736173 ! regulation of translational initiation GO:0006446 64 45 1,000 0,04474273 0,12720429 ! cell maturation GO:0048469 60 45 1,000 0,04474273 0,12704725 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,04474273 0,1268906 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04655219 0,13185966 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,04655219 0,13169747 ! viral infectious cycle GO:0019058 71 47 1,000 0,04838818 0,13672337 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04838818 0,13655561 ! response to temperature stimulus GO:0009266 62 48 1,000 0,05025021 0,14163662 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,05025021 0,14146326 ! nuclear export GO:0051168 69 48 1,000 0,05025021 0,14129032 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,051298 0,14406031 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,051298 0,14388463 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,051298 0,14370937 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,051298 0,14353454 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,051298 0,14336014 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,051298 0,14318616 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,051298 0,1430126 GO:0070193|synaptonemal complex organization, ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,051298 0,14283946 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,051298 0,14266674 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,051298 0,14249444 ! reproductive behavior GO:0019098 12 7 0,000 0,051298 0,14232255 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,051298 0,14215108 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,051298 0,14198002 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,051298 0,14180937 ! oligopeptide transport GO:0006857 11 7 0,000 0,051298 0,14163913 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,051298 0,1414693 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,051298 0,14129987 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,051298 0,14113085 ! RNA methylation GO:0001510 11 7 0,000 0,051298 0,14096224 ! pericardium development GO:0060039 8 7 0,000 0,051298 0,14079403 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,051298 0,14062621 ! fibril organization GO:0043206 13 7 0,000 0,051298 0,1404588 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,051298 0,14029179 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,051298 0,14012517 ! lipoprotein transport GO:0042953 9 7 0,000 0,051298 0,13995895 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,051298 0,13979312 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,051298 0,13962768 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,051298 0,13946264 ! estrogen metabolic process GO:0008210 14 7 0,000 0,051298 0,13929798 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,051298 0,13913372 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,051298 0,13896984 ! chemosensory behavior GO:0007635 9 7 0,000 0,051298 0,13880635 ! microtubule bundle formation GO:0001578 8 7 0,000 0,051298 0,13864324 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,051298 0,13848051 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,051298 0,13831816 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,051298 0,1381562 ! leukocyte degranulation GO:0043299 10 7 0,000 0,051298 0,13799461 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,051298 0,1378334 ! reflex GO:0060004 12 7 0,000 0,051298 0,13767257 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,051298 0,13751211 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,051298 0,13735203 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,051298 0,13719232 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,051298 0,13703298 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,051298 0,13687401 ! spinal cord patterning GO:0021511 7 7 0,000 0,051298 0,1367154 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,051298 0,13655717 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,051298 0,1363993 ! adrenal gland development GO:0030325 17 7 0,000 0,051298 0,13624179 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,051298 0,13608465 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,051298 0,13592787 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,051298 0,13577145 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,051298 0,13561539 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,051298 0,13545969 ! endosome organization GO:0007032 10 7 0,000 0,051298 0,13530435 ! thyroid hormone generation GO:0006590 11 7 0,000 0,051298 0,13514936 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,051298 0,13499473 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,051298 0,13484045 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,051298 0,13468652 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,051298 0,13453295 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,051298 0,13437972 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,051298 0,13422684 ! galactose metabolic process GO:0006012 10 7 0,000 0,051298 0,13407431 ! intracellular pH reduction GO:0051452 10 7 0,000 0,051298 0,13392213 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,051298 0,13377029 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,051298 0,13361879 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,051298 0,13346764 ! retinol metabolic process GO:0042572 9 7 0,000 0,051298 0,13331683 ! behavioral fear response GO:0001662 13 7 0,000 0,051298 0,13316636 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,051298 0,13301623 ! rRNA modification GO:0000154 12 7 0,000 0,051298 0,13286643 ! protein heterooligomerization GO:0051291 10 7 0,000 0,051298 0,13271698 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,051298 0,13256786 ! response to UV-B GO:0010224 11 7 0,000 0,051298 0,13241907 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,051298 0,13227062 ! intermediate filament organization GO:0045109 11 7 0,000 0,051298 0,1321225 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,051298 0,13197471 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,051298 0,13182726 ! fibrinolysis GO:0042730 9 7 0,000 0,051298 0,13168013 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,051298 0,13153333 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,051298 0,13138685 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,051298 0,1312407 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,051298 0,13109488 ! response to tropane GO:0014073 13 7 0,000 0,051298 0,13094938 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,051298 0,13080421 ! melanosome localization GO:0032400 10 7 0,000 0,051298 0,13065935 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,051298 0,13051482 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,051298 0,1303706 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,051298 0,1302267 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,051298 0,13008312 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,051298 0,12993986 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,051298 0,12979691 ! mast cell activation GO:0045576 9 7 0,000 0,051298 0,12965428 ! multicellular organismal aging GO:0010259 11 7 0,000 0,051298 0,12951196 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,051298 0,12936995 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,051298 0,12922825 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,051298 0,12908686 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,051298 0,12894578 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,051298 0,12880501 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,051298 0,12866455 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,051298 0,12852439 ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,051298 0,12838454 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,051298 0,12824499 ! regulation of lipid transport GO:0032368 13 7 0,000 0,051298 0,12810575 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,051298 0,1279668 ! neuroblast proliferation GO:0007405 13 7 0,000 0,051298 0,12782816 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,051298 0,12768982 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,051298 0,12755178 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,051298 0,12741403 ! diuresis GO:0030146 12 7 0,000 0,051298 0,12727658 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,051298 0,12713943 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,051298 0,12700258 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,051298 0,12686601 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,051298 0,12672975 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,051298 0,12659377 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,051298 0,12645808 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,051298 0,12632269 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,051298 0,12618759 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,051298 0,12605277 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,051298 0,12591824 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,051298 0,125784 ! lymph node development GO:0048535 9 7 0,000 0,051298 0,12565005 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,051298 0,12551638 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,051298 0,12538299 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,051298 0,12524989 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,051298 0,12511707 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,051298 0,12498453 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,051298 0,12485227 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,051298 0,12472029 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,051298 0,12458859 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,051298 0,12445717 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,051298 0,12432602 ! muscle adaptation GO:0043500 12 7 0,000 0,051298 0,12419515 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,051298 0,12406456 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,051298 0,12393424 ! retina homeostasis GO:0001895 9 7 0,000 0,051298 0,12380419 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,051298 0,12367442 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,051298 0,12354491 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,051298 0,12341568 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,051298 0,12328672 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,051298 0,12315803 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,05213778 0,12504368 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,05213778 0,12491343 ! germ cell development GO:0007281 68 49 1,000 0,05213778 0,12478345 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,05213778 0,12465374 ! maintenance of location GO:0051235 84 49 1,000 0,05213778 0,12452429 ! ear development GO:0043583 72 50 1,000 0,05405042 0,12895846 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05405042 0,12882483 ! membrane fusion GO:0006944 80 50 1,000 0,05405042 0,12869147 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,05405042 0,12855839 ! proton transport GO:0015992 75 50 1,000 0,05405042 0,12842558 ! hydrogen transport GO:0006818 77 51 1,000 0,05598764 0,13289121 ! muscle fiber development GO:0048747 74 51 1,000 0,05598764 0,13275421 ! positive regulation of cell migration GO:0030335 92 51 1,000 0,05598764 0,13261749 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,05598764 0,13248105 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05840987 0,13807061 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05840987 0,13792885 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,05840987 0,13778738 ! axon extension GO:0048675 11 8 0,000 0,05840987 0,13764621 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05840987 0,13750532 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05840987 0,13736472 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05840987 0,13722441 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05840987 0,13708439 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05840987 0,13694465 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05840987 0,13680519 ! phosphate transport GO:0006817 10 8 0,000 0,05840987 0,13666602 ! N-glycan processing GO:0006491 12 8 0,000 0,05840987 0,13652713 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05840987 0,13638853 ! UTP metabolic process GO:0046051 8 8 0,000 0,05840987 0,1362502 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05840987 0,13611216 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05840987 0,13597439 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,05840987 0,1358369 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05840987 0,1356997 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,05840987 0,13556276 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05840987 0,13542611 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05840987 0,13528973 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05840987 0,13515362 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05840987 0,13501779 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05840987 0,13488223 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05840987 0,13474694 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05840987 0,13461192 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05840987 0,13447718 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05840987 0,1343427 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05840987 0,13420849 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05840987 0,13407455 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05840987 0,13394088 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05840987 0,13380747 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05840987 0,13367433 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05840987 0,13354145 ! melanin metabolic process GO:0006582 12 8 0,000 0,05840987 0,13340884 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05840987 0,13327649 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05840987 0,1331444 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,05840987 0,13301257 ! macrophage activation GO:0042116 12 8 0,000 0,05840987 0,13288101 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05840987 0,1327497 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05840987 0,13261866 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05840987 0,13248787 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05840987 0,13235734 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05840987 0,13222707 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05840987 0,13209705 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05840987 0,13196729 ! ruffle organization GO:0031529 11 8 0,000 0,05840987 0,13183778 ! osteoblast development GO:0002076 13 8 0,000 0,05840987 0,13170853 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05840987 0,13157953 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05840987 0,13145078 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05840987 0,13132229 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05840987 0,13119404 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05840987 0,13106605 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05840987 0,1309383 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05840987 0,13081081 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05840987 0,13068356 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05840987 0,13055656 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05840987 0,1304298 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05840987 0,1303033 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05840987 0,13017703 ! segment specification GO:0007379 10 8 0,000 0,05840987 0,13005102 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05840987 0,12992524 ! cellular extravasation GO:0045123 11 8 0,000 0,05840987 0,12979971 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05840987 0,12967442 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05840987 0,12954937 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05840987 0,12942457 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05840987 0,1293 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05840987 0,12917567 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05840987 0,12905158 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05840987 0,12892773 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05840987 0,12880412 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05840987 0,12868075 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05840987 0,12855761 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05840987 0,1284347 ! icosanoid secretion GO:0032309 12 8 0,000 0,05840987 0,12831203 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05840987 0,1281896 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05840987 0,1280674 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05840987 0,12794543 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05840987 0,12782369 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05840987 0,12770219 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05840987 0,12758091 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05840987 0,12745987 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05840987 0,12733905 ! sterol catabolic process GO:0016127 9 8 0,000 0,05840987 0,12721846 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05840987 0,12709811 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05840987 0,12697798 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05840987 0,12685807 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05840987 0,1267384 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05840987 0,12661894 ! prophase GO:0051324 11 8 0,000 0,05840987 0,12649972 ! S phase GO:0051320 8 8 0,000 0,05840987 0,12638071 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05840987 0,12626193 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05840987 0,12614338 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05840987 0,12602505 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05840987 0,12590693 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05840987 0,12578904 ! hormone catabolic process GO:0042447 13 8 0,000 0,05840987 0,12567137 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05840987 0,12555392 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05840987 0,12543669 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05840987 0,12531968 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05840987 0,12520289 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05840987 0,12508631 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05840987 0,12496995 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05840987 0,12485381 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05840987 0,12473788 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05840987 0,12462217 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05840987 0,12450667 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05840987 0,12439139 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05840987 0,12427632 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05840987 0,12416146 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05840987 0,12404681 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,059934 0,12716623 ! DNA catabolic process GO:0006308 67 54 1,000 0,0619422 0,13130605 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,06397315 0,13548642 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06546883 0,13852651 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06546883 0,13839918 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06546883 0,1382721 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06546883 0,13814524 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06546883 0,13801862 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06546883 0,13789223 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06546883 0,13776607 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06546883 0,13764014 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06546883 0,13751444 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06546883 0,13738897 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06546883 0,13726373 ! GTP metabolic process GO:0046039 9 9 0,000 0,06546883 0,13713872 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06546883 0,13701393 ! social behavior GO:0035176 14 9 0,000 0,06546883 0,13688937 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06546883 0,13676504 ! artery development GO:0060840 19 9 0,000 0,06546883 0,13664094 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06546883 0,13651706 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06546883 0,1363934 ! response to pain GO:0048265 16 9 0,000 0,06546883 0,13626997 ! protein complex disassembly GO:0043241 17 9 0,000 0,06546883 0,13614676 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06546883 0,13602377 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06546883 0,135901 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06546883 0,13577846 ! lung alveolus development GO:0048286 17 9 0,000 0,06546883 0,13565614 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06546883 0,13553403 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06546883 0,13541215 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06546883 0,13529049 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06546883 0,13516904 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06546883 0,13504781 ! protein targeting to ER GO:0045047 19 9 0,000 0,06546883 0,1349268 ! endoderm development GO:0007492 12 9 0,000 0,06546883 0,13480601 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06546883 0,13468543 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06546883 0,13456507 ! arginine catabolic process GO:0006527 10 9 0,000 0,06546883 0,13444492 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06546883 0,13432499 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06546883 0,13420527 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06546883 0,13408576 ! V(D)J recombination GO:0033151 12 9 0,000 0,06546883 0,13396647 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06546883 0,13384739 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06546883 0,13372852 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06546883 0,13360986 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06546883 0,13349141 ! mannose metabolic process GO:0006013 9 9 0,000 0,06546883 0,13337317 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06546883 0,13325514 ! receptor clustering GO:0043113 15 9 0,000 0,06546883 0,13313732 ! epithelial cell development GO:0002064 10 9 0,000 0,06546883 0,13301971 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06546883 0,13290231 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06546883 0,13278511 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06546883 0,13266812 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06546883 0,13255133 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06546883 0,13243475 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06546883 0,13231838 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06546883 0,13220221 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06546883 0,13208624 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06546883 0,13197048 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06546883 0,13185491 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06546883 0,13173956 ! DNA ligation GO:0006266 14 9 0,000 0,06546883 0,1316244 ! response to amine stimulus GO:0014075 13 9 0,000 0,06546883 0,13150944 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06546883 0,13139469 ! erythrocyte development GO:0048821 11 9 0,000 0,06546883 0,13128013 ! renal water homeostasis GO:0003091 14 9 0,000 0,06546883 0,13116578 ! postreplication repair GO:0006301 11 9 0,000 0,06546883 0,13105162 ! mRNA cleavage GO:0006379 13 9 0,000 0,06546883 0,13093766 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06546883 0,1308239 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06546883 0,13071034 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06546883 0,13059697 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06546883 0,13048381 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06546883 0,13037083 ! acid secretion GO:0046717 14 9 0,000 0,06546883 0,13025806 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06546883 0,13014547 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06546883 0,13003308 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06546883 0,12992089 ! purine base metabolic process GO:0006144 18 9 0,000 0,06546883 0,12980889 ! thymus development GO:0048538 15 9 0,000 0,06546883 0,12969708 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06546883 0,12958547 ! spleen development GO:0048536 15 9 0,000 0,06546883 0,12947404 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06546883 0,12936281 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06546883 0,12925177 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06546883 0,12914092 ! detection of calcium ion GO:0005513 13 9 0,000 0,06546883 0,12903026 ! blastocyst formation GO:0001825 12 9 0,000 0,06546883 0,12891979 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06546883 0,12880951 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06546883 0,12869941 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06546883 0,12858951 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06546883 0,12847979 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06546883 0,12837026 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06546883 0,12826091 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06546883 0,12815175 ! prepulse inhibition GO:0060134 14 9 0,000 0,06546883 0,12804278 ! embryonic placenta development GO:0001892 12 9 0,000 0,06546883 0,12793399 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06546883 0,12782539 ! insulin secretion GO:0030073 17 9 0,000 0,06546883 0,12771697 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06546883 0,12760874 ! response to nicotine GO:0035094 16 9 0,000 0,06546883 0,12750069 ! nucleus localization GO:0051647 15 9 0,000 0,06546883 0,12739282 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06546883 0,12728513 ! localization within membrane GO:0051668 15 9 0,000 0,06546883 0,12717763 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,0660264 0,12815251 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,0660264 0,12804446 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,0660264 0,12793658 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,06810151 0,13184635 ! developmental maturation GO:0021700 75 57 1,000 0,06810151 0,13173546 ! gonad development GO:0008406 79 57 1,000 0,06810151 0,13162476 ! chromosome segregation GO:0007059 83 57 1,000 0,06810151 0,13151424 ! viral reproductive process GO:0022415 87 58 1,000 0,07019803 0,13544922 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,07019803 0,13533568 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07247527 0,13960899 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07247527 0,13949216 ! neuron fate specification GO:0048665 11 10 0,000 0,07247527 0,13937553 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07247527 0,13925909 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07247527 0,13914285 ! thyroid gland development GO:0030878 19 10 0,000 0,07247527 0,1390268 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07247527 0,13891094 ! synapsis GO:0007129 13 10 0,000 0,07247527 0,13879528 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07247527 0,13867981 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07247527 0,13856453 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07247527 0,13844944 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07247527 0,13833455 ! sulfate transport GO:0008272 12 10 0,000 0,07247527 0,13821984 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07247527 0,13810533 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07247527 0,137991 ! androgen metabolic process GO:0008209 13 10 0,000 0,07247527 0,13787687 ! phospholipid efflux GO:0033700 16 10 0,000 0,07247527 0,13776292 ! hippocampus development GO:0021766 19 10 0,000 0,07247527 0,13764916 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07247527 0,13753559 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07247527 0,1374222 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07247527 0,137309 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07247527 0,13719599 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07247527 0,13708317 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07247527 0,13697053 ! pathogenesis GO:0009405 13 10 0,000 0,07247527 0,13685807 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07247527 0,1367458 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07247527 0,13663371 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07247527 0,13652181 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07247527 0,13641009 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07247527 0,13629855 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07247527 0,1361872 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07247527 0,13607603 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07247527 0,13596503 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07247527 0,13585422 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07247527 0,13574359 ! B cell proliferation GO:0042100 14 10 0,000 0,07247527 0,13563314 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07247527 0,13552287 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07247527 0,13541278 ! forebrain cell migration GO:0021885 17 10 0,000 0,07247527 0,13530287 ! lipid digestion GO:0044241 15 10 0,000 0,07247527 0,13519313 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07247527 0,13508357 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07247527 0,1349742 ! UV protection GO:0009650 14 10 0,000 0,07247527 0,13486499 ! entry into host cell GO:0030260 20 10 0,000 0,07247527 0,13475597 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07247527 0,13464712 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07247527 0,13453844 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07247527 0,13442994 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07247527 0,13432162 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07247527 0,13421347 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07247527 0,1341055 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07247527 0,13399769 ! regulation of organ growth GO:0046620 11 10 0,000 0,07247527 0,13389007 ! response to dsRNA GO:0043331 18 10 0,000 0,07247527 0,13378261 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07247527 0,13367533 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07247527 0,13356821 ! embryonic axis specification GO:0000578 12 10 0,000 0,07247527 0,13346127 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07247527 0,13335451 ! cranial nerve development GO:0021545 12 10 0,000 0,07247527 0,13324791 ! fucose catabolic process GO:0019317 16 10 0,000 0,07247527 0,13314148 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07247527 0,13303522 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07247527 0,13292913 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07247527 0,13282321 ! zymogen activation GO:0031638 14 10 0,000 0,07247527 0,13271746 ! salivary gland development GO:0007431 22 10 0,000 0,07247527 0,13261188 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07247527 0,13250646 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07247527 0,13240122 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07247527 0,13229614 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07247527 0,13219122 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07247527 0,13208648 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07247527 0,13198189 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07247527 0,13187748 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07247527 0,13177323 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07247527 0,13166914 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07247527 0,13156522 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07247527 0,13146146 ! detection of bacterium GO:0016045 10 10 0,000 0,07247527 0,13135787 ! embryonic gut development GO:0048566 11 10 0,000 0,07247527 0,13125443 ! activation of innate immune response GO:0002218 10 10 0,000 0,07247527 0,13115117 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07247527 0,13104806 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07247527 0,13094512 ! developmental induction GO:0031128 13 10 0,000 0,07247527 0,13084233 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07247527 0,13073971 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07247527 0,13063725 ! rRNA transcription GO:0009303 17 11 0,000 0,07942959 0,14306034 ! respiratory burst GO:0045730 14 11 0,000 0,07942959 0,1429484 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07942959 0,14283663 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07942959 0,14272504 ! virus-host interaction GO:0019048 17 11 0,000 0,07942959 0,14261362 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,07942959 0,14250238 ! filopodium assembly GO:0046847 19 11 0,000 0,07942959 0,14239131 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07942959 0,14228041 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07942959 0,14216969 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,07942959 0,14205914 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,07942959 0,14194876 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07942959 0,14183855 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07942959 0,14172851 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07942959 0,14161864 ! bone resorption GO:0045453 16 11 0,000 0,07942959 0,14150895 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07942959 0,14139942 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07942959 0,14129006 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07942959 0,14118087 ! syncytium formation GO:0006949 15 11 0,000 0,07942959 0,14107185 ! plasma membrane organization GO:0007009 18 11 0,000 0,07942959 0,140963 ! focal adhesion formation GO:0048041 24 11 0,000 0,07942959 0,14085432 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07942959 0,1407458 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07942959 0,14063745 ! adult heart development GO:0007512 11 11 0,000 0,07942959 0,14052927 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07942959 0,14042125 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,07942959 0,1403134 ! temperature homeostasis GO:0001659 16 11 0,000 0,07942959 0,14020572 ! L-glutamate transport GO:0015813 16 11 0,000 0,07942959 0,1400982 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07942959 0,13999084 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07942959 0,13988365 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07942959 0,13977663 ! stem cell development GO:0048864 29 11 0,000 0,07942959 0,13966976 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07942959 0,13956306 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07942959 0,13945653 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07942959 0,13935015 ! vasoconstriction GO:0042310 15 11 0,000 0,07942959 0,13924394 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07942959 0,13913789 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07942959 0,139032 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07942959 0,13892627 ! ribosome assembly GO:0042255 13 11 0,000 0,07942959 0,13882071 ! histone deacetylation GO:0016575 13 11 0,000 0,07942959 0,1387153 ! chromatin silencing GO:0006342 19 11 0,000 0,07942959 0,13861005 ! nucleosome positioning GO:0016584 13 11 0,000 0,07942959 0,13850497 ! T cell homeostasis GO:0043029 20 11 0,000 0,07942959 0,13840004 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,07942959 0,13829527 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07942959 0,13819066 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07942959 0,1380862 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07942959 0,13798191 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07942959 0,13787777 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07942959 0,13777379 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07942959 0,13766997 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07942959 0,1375663 ! male genitalia development GO:0030539 13 11 0,000 0,07942959 0,13746279 ! cholesterol efflux GO:0033344 19 11 0,000 0,07942959 0,13735944 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07942959 0,13725624 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07942959 0,13715319 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07942959 0,1370503 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07942959 0,13694756 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07942959 0,13684498 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07942959 0,13674255 ! defense response to fungus GO:0050832 12 11 0,000 0,07942959 0,13664028 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07942959 0,13653815 ! acrosome reaction GO:0007340 13 11 0,000 0,07942959 0,13643618 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07942959 0,13633437 ! viral reproduction GO:0016032 92 63 1,000 0,08098699 0,13890387 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,08320314 0,14259853 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,08320314 0,14249235 ! reproductive structure development GO:0048608 90 65 1,000 0,08543779 0,14621051 ! B cell activation GO:0042113 104 65 1,000 0,08543779 0,1461018 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08543779 0,14599326 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,08543779 0,14588487 ! activation of immune response GO:0002253 83 65 1,000 0,08543779 0,14577665 ! protein oligomerization GO:0051259 100 65 1,000 0,08543779 0,14566859 ! lactation GO:0007595 20 12 0,000 0,08633215 0,14708441 ! reproductive cellular process GO:0048610 14 12 0,000 0,08633215 0,14697554 ! tRNA modification GO:0006400 14 12 0,000 0,08633215 0,14686683 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08633215 0,14675828 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08633215 0,14664989 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08633215 0,14654166 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08633215 0,14643359 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08633215 0,14632568 ! non-recombinational repair GO:0000726 19 12 0,000 0,08633215 0,14621793 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08633215 0,14611034 ! peroxisomal transport GO:0043574 21 12 0,000 0,08633215 0,1460029 ! cartilage condensation GO:0001502 18 12 0,000 0,08633215 0,14589563 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08633215 0,14578851 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08633215 0,14568155 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08633215 0,14557474 ! heart looping GO:0001947 15 12 0,000 0,08633215 0,1454681 ! palate development GO:0060021 15 12 0,000 0,08633215 0,1453616 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08633215 0,14525527 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08633215 0,14514909 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08633215 0,14504306 ! arginine metabolic process GO:0006525 13 12 0,000 0,08633215 0,14493719 ! methionine metabolic process GO:0006555 13 12 0,000 0,08633215 0,14483147 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08633215 0,14472591 ! Golgi organization GO:0007030 18 12 0,000 0,08633215 0,1446205 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08633215 0,14451525 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08633215 0,14441015 ! monoamine transport GO:0015844 13 12 0,000 0,08633215 0,1443052 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08633215 0,1442004 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08633215 0,14409575 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08633215 0,14399126 ! L-amino acid transport GO:0015807 20 12 0,000 0,08633215 0,14388692 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08633215 0,14378273 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08633215 0,14367869 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08633215 0,1435748 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08633215 0,14347106 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08633215 0,14336747 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08633215 0,14326403 ! cerebellum development GO:0021549 13 12 0,000 0,08633215 0,14316074 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08633215 0,1430576 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08633215 0,14295461 ! histone acetylation GO:0016573 23 12 0,000 0,08633215 0,14285176 ! histone methylation GO:0016571 15 12 0,000 0,08633215 0,14274907 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08633215 0,14264652 ! gland morphogenesis GO:0022612 23 12 0,000 0,08633215 0,14254411 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08633215 0,14244186 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08633215 0,14233975 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08633215 0,14223779 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08633215 0,14213597 ! intestinal absorption GO:0050892 19 12 0,000 0,08633215 0,1420343 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08633215 0,14193277 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08633215 0,14183139 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08633215 0,14173016 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08633215 0,14162907 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08633215 0,14152812 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08633215 0,14142731 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08633215 0,14132665 ! microspike assembly GO:0030035 23 12 0,000 0,08633215 0,14122614 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08633215 0,14112576 ! response to cold GO:0009409 14 12 0,000 0,08633215 0,14102553 ! regulation of immune effector process GO:0002697 101 66 1,000 0,08769055 0,14314284 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,08996102 0,14674493 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,08996102 0,14664093 ! learning or memory GO:0007611 123 68 1,000 0,09224882 0,15026367 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,09224882 0,15015732 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,09224882 0,15005113 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09318335 0,15146411 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09318335 0,15135714 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09318335 0,15125033 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09318335 0,15114366 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09318335 0,15103715 ! water transport GO:0006833 17 13 0,000 0,09318335 0,15093078 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09318335 0,15082457 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09318335 0,1507185 ! lipid localization GO:0010876 24 13 0,000 0,09318335 0,15061259 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09318335 0,15050682 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09318335 0,1504012 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09318335 0,15029573 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09318335 0,15019041 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09318335 0,15008523 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09318335 0,14998021 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09318335 0,14987532 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,09318335 0,14977059 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09318335 0,149666 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09318335 0,14956156 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09318335 0,14945726 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09318335 0,14935311 ! NAD metabolic process GO:0019674 21 13 0,000 0,09318335 0,1492491 ! exocrine system development GO:0035272 27 13 0,000 0,09318335 0,14914524 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09318335 0,14904153 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09318335 0,14893795 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09318335 0,14883452 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09318335 0,14873124 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09318335 0,1486281 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09318335 0,1485251 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,09318335 0,14842224 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,09318335 0,14831952 ! genitalia development GO:0048806 15 13 0,000 0,09318335 0,14821695 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,09318335 0,14811452 ! tissue regeneration GO:0042246 21 13 0,000 0,09318335 0,14801223 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09318335 0,14791009 ! cofactor transport GO:0051181 19 13 0,000 0,09318335 0,14780808 ! NADP metabolic process GO:0006739 18 13 0,000 0,09318335 0,14770621 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09318335 0,14760449 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09318335 0,1475029 ! gas transport GO:0015669 18 13 0,000 0,09318335 0,14740145 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09318335 0,14730015 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09318335 0,14719898 ! regulation of axon extension GO:0030516 23 13 0,000 0,09318335 0,14709795 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09318335 0,14699706 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,09318335 0,14689631 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09318335 0,14679569 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09318335 0,14669522 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09318335 0,14659488 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09318335 0,14649468 ! response to metal ion GO:0010038 103 70 1,000 0,09687489 0,15219415 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,09687489 0,15209026 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,0992124 0,15565383 ! muscle cell differentiation GO:0042692 104 71 1,000 0,0992124 0,15554772 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09998357 0,15665001 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,09998357 0,15654337 ! superoxide anion generation GO:0042554 18 14 0,000 0,09998357 0,15643688 ! neuron maturation GO:0042551 21 14 0,000 0,09998357 0,15633053 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09998357 0,15622433 ! myotube differentiation GO:0014902 21 14 0,000 0,09998357 0,15611827 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,09998357 0,15601235 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,09998357 0,15590658 ! inositol metabolic process GO:0006020 20 14 0,000 0,09998357 0,15580096 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09998357 0,15569547 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09998357 0,15559013 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09998357 0,15548493 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09998357 0,15537987 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09998357 0,15527496 ! response to cAMP GO:0051591 19 14 0,000 0,09998357 0,15517018 ! limbic system development GO:0021761 25 14 0,000 0,09998357 0,15506555 ! startle response GO:0001964 21 14 0,000 0,09998357 0,15496106 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09998357 0,15485671 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09998357 0,1547525 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09998357 0,15464843 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09998357 0,1545445 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,09998357 0,15444071 ! glycine metabolic process GO:0006544 22 14 0,000 0,09998357 0,15433705 ! pituitary gland development GO:0021983 23 14 0,000 0,09998357 0,15423354 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09998357 0,15413017 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09998357 0,15402693 ! regulation of heart rate GO:0002027 23 14 0,000 0,09998357 0,15392384 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09998357 0,15382088 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,09998357 0,15371806 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,09998357 0,15361537 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09998357 0,15351282 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09998357 0,15341041 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09998357 0,15330814 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09998357 0,153206 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09998357 0,153104 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09998357 0,15300214 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09998357 0,15290041 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09998357 0,15279881 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09998357 0,15269735 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09998357 0,15259603 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09998357 0,15249483 ! muscle maintenance GO:0046716 19 14 0,000 0,09998357 0,15239378 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09998357 0,15229285 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09998357 0,15219207 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09998357 0,15209141 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09998357 0,15199089 ! cell killing GO:0001906 20 14 0,000 0,09998357 0,1518905 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09998357 0,15179024 ! cilium assembly GO:0042384 20 14 0,000 0,09998357 0,15169011 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09998357 0,15159012 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,10156573 0,15388747 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 1,000 0,10393453 0,15737289 ! tube morphogenesis GO:0035239 118 73 1,000 0,10393453 0,15726936 ! protein import into nucleus GO:0006606 118 74 1,000 0,10631843 0,16077081 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,10631843 0,16066518 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10673318 0,16118602 ! metencephalon development GO:0022037 19 15 0,000 0,10673318 0,16108026 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10673318 0,16097463 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10673318 0,16086914 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10673318 0,16076379 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10673318 0,16065858 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,10673318 0,16055351 ! lipid phosphorylation GO:0046834 23 15 0,000 0,10673318 0,16044857 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10673318 0,16034377 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10673318 0,16023911 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10673318 0,16013458 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10673318 0,16003019 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10673318 0,15992593 ! adult walking behavior GO:0007628 25 15 0,000 0,10673318 0,15982182 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10673318 0,15971783 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10673318 0,15961399 ! myoblast differentiation GO:0045445 27 15 0,000 0,10673318 0,15951027 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10673318 0,15940669 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10673318 0,15930325 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10673318 0,15919994 ! cerebral cortex development GO:0021987 29 15 0,000 0,10673318 0,15909677 ! response to osmotic stress GO:0006970 22 15 0,000 0,10673318 0,15899372 ! vesicle coating GO:0006901 25 15 0,000 0,10673318 0,15889082 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10673318 0,15878804 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,10673318 0,1586854 ! peptide secretion GO:0002790 27 15 0,000 0,10673318 0,15858289 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10673318 0,15848051 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10673318 0,15837826 ! neuron recognition GO:0008038 22 15 0,000 0,10673318 0,15827615 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10673318 0,15817417 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10673318 0,15807232 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,10673318 0,1579706 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10673318 0,15786901 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10673318 0,15776755 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10673318 0,15766622 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10673318 0,15756503 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10673318 0,15746396 ! organic cation transport GO:0015695 19 15 0,000 0,10673318 0,15736302 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10673318 0,15726221 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10673318 0,15716153 ! peptide hormone processing GO:0016486 19 15 0,000 0,10673318 0,15706098 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10673318 0,15696056 ! blood coagulation GO:0007596 116 75 1,000 0,10871709 0,15977591 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,10871709 0,15967388 ! response to nutrient GO:0007584 104 75 1,000 0,10871709 0,15957198 ! nuclear import GO:0051170 121 75 1,000 0,10871709 0,15947021 ! response to unfolded protein GO:0006986 99 76 1,000 0,11113013 0,16290587 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,11113013 0,16280211 ! regulation of protein transport GO:0051223 114 76 1,000 0,11113013 0,16269848 GO:0070201|regulation of establishment of protein localization, ! protein secretion GO:0009306 27 16 0,000 0,11343255 0,16596366 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11343255 0,16585815 ! hormone secretion GO:0046879 25 16 0,000 0,11343255 0,16575278 ! bone remodeling GO:0046849 24 16 0,000 0,11343255 0,16564754 ! endothelial cell migration GO:0043542 22 16 0,000 0,11343255 0,16554243 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11343255 0,16543746 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11343255 0,16533262 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11343255 0,16522791 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11343255 0,16512333 ! glial cell development GO:0021782 24 16 0,000 0,11343255 0,16501889 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11343255 0,16491458 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11343255 0,1648104 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11343255 0,16470636 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11343255 0,16460244 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11343255 0,16449866 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11343255 0,164395 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11343255 0,16429148 ! fructose metabolic process GO:0006000 20 16 0,000 0,11343255 0,16418809 ! regulation of protein binding GO:0043393 27 16 0,000 0,11343255 0,16408482 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11343255 0,16398169 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11343255 0,16387869 ! protein export from nucleus GO:0006611 24 16 0,000 0,11343255 0,16377581 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11343255 0,16367307 ! DNA replication initiation GO:0006270 25 16 0,000 0,11343255 0,16357045 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11343255 0,16346796 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11343255 0,1633656 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11343255 0,16326337 ! diencephalon development GO:0021536 25 16 0,000 0,11343255 0,16316127 ! G1 phase GO:0051318 27 16 0,000 0,11343255 0,16305929 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11343255 0,16295744 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11343255 0,16285572 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11343255 0,16275413 ! steroid catabolic process GO:0006706 22 16 0,000 0,11343255 0,16265266 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11343255 0,16255132 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11343255 0,1624501 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11343255 0,16234902 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11343255 0,16224805 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11343255 0,16214721 ! nerve development GO:0021675 18 16 0,000 0,11343255 0,1620465 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11343255 0,16194591 ! negative regulation of translation GO:0017148 22 16 0,000 0,11343255 0,16184545 ! sex differentiation GO:0007548 105 77 1,000 0,11355724 0,1619229 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,11355724 0,16182258 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,11355724 0,16172238 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,11599805 0,16509623 ! oxidative phosphorylation GO:0006119 105 79 1,000 0,11845223 0,16848493 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,11845223 0,1683808 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12008206 0,17059218 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12008206 0,17048688 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,12008206 0,1703817 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12008206 0,17027666 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,12008206 0,17017174 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,12008206 0,17006696 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12008206 0,1699623 ! signal complex assembly GO:0007172 29 17 0,000 0,12008206 0,16985777 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12008206 0,16975337 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,12008206 0,1696491 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12008206 0,16954496 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,12008206 0,16944094 ! memory GO:0007613 25 17 0,000 0,12008206 0,16933706 ! keratinization GO:0031424 17 17 0,000 0,12008206 0,1692333 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12008206 0,16912966 ! retinoid metabolic process GO:0001523 22 17 0,000 0,12008206 0,16902616 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,12008206 0,16892278 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,12008206 0,16881952 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12008206 0,1687164 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12008206 0,16861339 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12008206 0,16851052 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,12008206 0,16840777 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,12008206 0,16830514 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12008206 0,16820264 ! membrane budding GO:0006900 29 17 0,000 0,12008206 0,16810027 ! heme metabolic process GO:0042168 27 17 0,000 0,12008206 0,16799802 ! actin filament bundle formation GO:0051017 26 17 0,000 0,12008206 0,16789589 ! body fluid secretion GO:0007589 27 17 0,000 0,12008206 0,16779389 ! stem cell differentiation GO:0048863 36 17 0,000 0,12008206 0,16769201 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12008206 0,16759025 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12008206 0,16748862 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12008206 0,16738712 ! sensory perception of pain GO:0019233 23 17 0,000 0,12008206 0,16728573 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12008206 0,16718447 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,12008206 0,16708333 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12008206 0,16698231 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,12008206 0,16688141 ! cell-cell junction organization GO:0045216 25 17 0,000 0,12008206 0,16678064 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,12008206 0,16667999 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12008206 0,16657946 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,12008206 0,16647905 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,12008206 0,16637876 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,12008206 0,16627859 ! alcohol catabolic process GO:0046164 104 80 1,000 0,12091945 0,16733739 ! protein localization in nucleus GO:0034504 133 80 1,000 0,12091945 0,16723677 ! forebrain development GO:0030900 131 80 1,000 0,12091945 0,16713626 ! hemostasis GO:0007599 125 81 1,000 0,12339939 0,17046161 ! response to protein stimulus GO:0051789 111 81 1,000 0,12339939 0,1703593 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,12339939 0,1702571 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,1258917 0,17359168 GO:0060348|bone development, ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12668208 0,17457686 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,12668208 0,17447232 ! positive regulation of translation GO:0045727 28 18 0,000 0,12668208 0,17436791 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12668208 0,17426362 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12668208 0,17415946 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12668208 0,17405542 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12668208 0,17395151 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12668208 0,17384772 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12668208 0,17374405 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12668208 0,17364051 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12668208 0,17353709 ! axis specification GO:0009798 26 18 0,000 0,12668208 0,17343379 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12668208 0,17333062 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12668208 0,17322757 ! pancreas development GO:0031016 26 18 0,000 0,12668208 0,17312464 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12668208 0,17302184 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12668208 0,17291915 ! response to retinoic acid GO:0032526 25 18 0,000 0,12668208 0,17281659 ! pigmentation during development GO:0048066 31 18 0,000 0,12668208 0,17271415 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12668208 0,17261183 ! fucose metabolic process GO:0006004 26 18 0,000 0,12668208 0,17250963 ! response to fungus GO:0009620 19 18 0,000 0,12668208 0,17240756 ! peptide cross-linking GO:0018149 31 18 0,000 0,12668208 0,1723056 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12668208 0,17220377 ! heart process GO:0003015 27 18 0,000 0,12668208 0,17210205 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12668208 0,17200046 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12668208 0,17189898 ! visual learning GO:0008542 35 18 0,000 0,12668208 0,17179763 ! somitogenesis GO:0001756 24 18 0,000 0,12668208 0,17169639 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12668208 0,17159527 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12668208 0,17149427 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12668208 0,1713934 ! vitamin transport GO:0051180 24 18 0,000 0,12668208 0,17129264 ! hormone transport GO:0009914 27 18 0,000 0,12668208 0,17119199 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12668208 0,17109147 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12668208 0,17099106 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12668208 0,17089078 ! cell-cell recognition GO:0009988 20 18 0,000 0,12668208 0,17079061 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12668208 0,17069055 ! regulation of glucose import GO:0046324 21 18 0,000 0,12668208 0,17059062 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,12668208 0,1704908 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,12668208 0,1703911 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13323296 0,17909749 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,13323296 0,17899288 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13323296 0,17888839 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13323296 0,17878402 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13323296 0,17867977 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,13323296 0,17857565 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,13323296 0,17847164 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,13323296 0,17836776 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13323296 0,178264 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13323296 0,17816035 ! regeneration GO:0031099 32 19 0,000 0,13323296 0,17805683 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13323296 0,17795343 ! sensory perception of taste GO:0050909 23 19 0,000 0,13323296 0,17785015 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13323296 0,17774699 ! peroxisome organization GO:0007031 29 19 0,000 0,13323296 0,17764395 ! digestive system process GO:0022600 30 19 0,000 0,13323296 0,17754102 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13323296 0,17743822 ! response to vitamin A GO:0033189 26 19 0,000 0,13323296 0,17733554 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13323296 0,17723297 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13323296 0,17713052 ! sex determination GO:0007530 29 19 0,000 0,13323296 0,1770282 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13323296 0,17692599 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13323296 0,17682389 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,13323296 0,17672192 ! cytolysis GO:0019835 20 19 0,000 0,13323296 0,17662006 ! renal system process GO:0003014 35 19 0,000 0,13323296 0,17651832 ! vasodilation GO:0042311 33 19 0,000 0,13323296 0,1764167 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13323296 0,17631519 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13323296 0,17621381 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13323296 0,17611253 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13323296 0,17601138 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13323296 0,17591034 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,13323296 0,17580941 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13323296 0,17570861 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13323296 0,17560791 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13323296 0,17550734 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13323296 0,17540687 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13323296 0,17530653 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13323296 0,17520629 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13323296 0,17510618 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,13323296 0,17500617 ! protein stabilization GO:0050821 26 19 0,000 0,13323296 0,17490628 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,13343977 0,17507785 ! transcription initiation GO:0006352 118 85 1,000 0,13343977 0,17497804 ! regulation of protein localization GO:0032880 132 85 1,000 0,13343977 0,17487834 ! regulation of membrane potential GO:0042391 128 85 1,000 0,13343977 0,17477875 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,13852797 0,18133997 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,13852797 0,18123682 GO:0060538|skeletal muscle organ development, ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13973508 0,18271215 ! iron ion transport GO:0006826 37 20 0,000 0,13973508 0,18260834 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13973508 0,18250464 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13973508 0,18240107 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,13973508 0,18229761 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13973508 0,18219426 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,13973508 0,18209104 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13973508 0,18198793 ! spinal cord development GO:0021510 31 20 0,000 0,13973508 0,18188493 ! response to ethanol GO:0045471 37 20 0,000 0,13973508 0,18178206 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13973508 0,1816793 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,13973508 0,18157665 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13973508 0,18147413 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13973508 0,18137171 ! chromosome condensation GO:0030261 31 20 0,000 0,13973508 0,18126942 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13973508 0,18116724 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,13973508 0,18106517 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13973508 0,18096322 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13973508 0,18086138 ! pallium development GO:0021543 38 20 0,000 0,13973508 0,18075966 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,13973508 0,18065805 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,13973508 0,18055656 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,13973508 0,18045518 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13973508 0,18035392 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13973508 0,18025276 ! collagen catabolic process GO:0030574 25 20 0,000 0,13973508 0,18015173 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,13973508 0,1800508 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13973508 0,17994999 ! actin filament-based movement GO:0030048 34 20 0,000 0,13973508 0,17984929 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,14108799 0,18148903 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,14108799 0,18138758 ! reproductive developmental process GO:0003006 127 89 1,000 0,14365824 0,1845888 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,14365824 0,18448573 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14618879 0,1876307 GO:0016444|somatic cell DNA recombination, ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14618879 0,18752605 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14618879 0,18742152 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14618879 0,18731711 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14618879 0,18721281 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14618879 0,18710863 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14618879 0,18700457 ! protein amino acid acylation GO:0043543 37 21 0,000 0,14618879 0,18690062 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,14618879 0,18679679 ! vesicle docking GO:0048278 27 21 0,000 0,14618879 0,18669307 ! dendrite development GO:0016358 35 21 0,000 0,14618879 0,18658946 ! visual behavior GO:0007632 39 21 0,000 0,14618879 0,18648598 ! ovarian follicle development GO:0001541 30 21 0,000 0,14618879 0,1863826 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14618879 0,18627934 ! autophagy GO:0006914 28 21 0,000 0,14618879 0,1861762 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14618879 0,18607317 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14618879 0,18597025 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14618879 0,18586745 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14618879 0,18576476 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14618879 0,18566218 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14618879 0,18555972 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14618879 0,18545737 ! fatty acid transport GO:0015908 30 21 0,000 0,14618879 0,18535513 ! platelet activation GO:0030168 28 21 0,000 0,14618879 0,18525301 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14618879 0,185151 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14618879 0,1850491 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,14618879 0,18494731 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14618879 0,18484564 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14618879 0,18474407 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,14618879 0,18464262 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14618879 0,18454128 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14618879 0,18444005 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14618879 0,18433893 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14618879 0,18423793 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14618879 0,18413703 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14618879 0,18403624 ! response to virus GO:0009615 122 91 1,000 0,14882822 0,18725652 ! positive regulation of immune response GO:0050778 121 92 1,000 0,15142739 0,19042263 ! sulfur metabolic process GO:0006790 118 92 1,000 0,15142739 0,19031857 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15259445 0,19168063 ! viral genome replication GO:0019079 29 22 0,000 0,15259445 0,191576 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15259445 0,19147149 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15259445 0,19136709 ! molting cycle process GO:0022404 40 22 0,000 0,15259445 0,1912628 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,15259445 0,19115863 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15259445 0,19105457 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,15259445 0,19095062 ! vasculogenesis GO:0001570 33 22 0,000 0,15259445 0,19084678 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,15259445 0,19074306 GO:0010810|regulation of cell-substrate adhesion, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15259445 0,19063946 ! lysosome organization GO:0007040 37 22 0,000 0,15259445 0,19053596 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15259445 0,19043258 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,15259445 0,1903293 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15259445 0,19022614 ! regulation of behavior GO:0050795 38 22 0,000 0,15259445 0,1901231 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15259445 0,19002016 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15259445 0,18991734 ! membrane depolarization GO:0051899 35 22 0,000 0,15259445 0,18981462 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15259445 0,18971202 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,15259445 0,18960953 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15259445 0,18950715 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15259445 0,18940488 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15259445 0,18930272 ! neural tube closure GO:0001843 33 22 0,000 0,15259445 0,18920067 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,15259445 0,18909873 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,15403562 0,19078187 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,15403562 0,19067918 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15895242 0,1966598 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15895242 0,19655407 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,15895242 0,19644845 ! vesicle targeting GO:0006903 32 23 0,000 0,15895242 0,19634295 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,15895242 0,19623755 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15895242 0,19613228 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,15895242 0,19602711 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15895242 0,19592206 ! interaction with host GO:0051701 37 23 0,000 0,15895242 0,19581712 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,15895242 0,19571229 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15895242 0,19560758 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15895242 0,19550298 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15895242 0,19539848 ! cell fate determination GO:0001709 45 23 0,000 0,15895242 0,19529411 ! pentose metabolic process GO:0019321 31 23 0,000 0,15895242 0,19518984 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15895242 0,19508568 ! spermatid development GO:0007286 33 23 0,000 0,15895242 0,19498163 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15895242 0,1948777 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15895242 0,19477388 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15895242 0,19467016 ! telomere organization GO:0032200 32 23 0,000 0,15895242 0,19456656 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,15895242 0,19446307 ! regulation of amine transport GO:0051952 38 23 0,000 0,15895242 0,19435968 ! liver development GO:0001889 40 23 0,000 0,15895242 0,19425641 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16526305 0,20186139 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,16526305 0,20175425 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16526305 0,20164722 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16526305 0,2015403 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,16526305 0,2014335 ! fat cell differentiation GO:0045444 37 24 0,000 0,16526305 0,2013268 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16526305 0,20122023 ! sperm motility GO:0030317 27 24 0,000 0,16526305 0,20111376 ! vacuole organization GO:0007033 39 24 0,000 0,16526305 0,20100741 ! receptor metabolic process GO:0043112 37 24 0,000 0,16526305 0,20090117 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16526305 0,20079504 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,16526305 0,20068902 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16526305 0,20058312 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,16526305 0,20047732 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,16526305 0,20037164 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16526305 0,20026607 ! calcium ion transport GO:0006816 167 99 1,000 0,16986012 0,20572843 ! protein import GO:0017038 156 99 1,000 0,16986012 0,20562015 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17152668 0,20752834 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17152668 0,20741923 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17152668 0,20731023 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17152668 0,20720135 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,17152668 0,20709258 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17152668 0,20698393 ! peptide transport GO:0015833 43 25 0,000 0,17152668 0,20687539 ! male gonad development GO:0008584 33 25 0,000 0,17152668 0,20676696 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,17152668 0,20665865 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17152668 0,20655045 ! phospholipid transport GO:0015914 35 25 0,000 0,17152668 0,20644237 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,17152668 0,2063344 GO:0045840|positive regulation of mitosis, ! regulation of translation GO:0006417 151 100 1,000 0,17252424 0,2074259 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,17252424 0,20731753 ! divalent metal ion transport GO:0070838 171 100 1,000 0,17252424 0,20720927 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,17252424 0,20710112 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,17252424 0,20699309 ! protein localization in organelle GO:0033365 161 100 1,000 0,17252424 0,20688517 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17774367 0,21303306 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,17774367 0,21292211 ! translational initiation GO:0006413 43 26 0,000 0,17774367 0,21281127 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,17774367 0,21270054 ! circadian rhythm GO:0007623 42 26 0,000 0,17774367 0,21258994 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17774367 0,21247944 ! post-embryonic development GO:0009791 42 26 0,000 0,17774367 0,21236906 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17774367 0,2122588 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17774367 0,21214865 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17774367 0,21203861 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,17774367 0,21192869 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17774367 0,21181888 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17774367 0,21170919 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17774367 0,21159961 ! regulation of coagulation GO:0050818 39 26 0,000 0,17774367 0,21149014 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18391436 0,21871925 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18391436 0,21860622 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18391436 0,2184933 ! membrane docking GO:0022406 39 27 0,000 0,18391436 0,2183805 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18391436 0,21826782 ! catechol metabolic process GO:0009712 43 27 0,000 0,18391436 0,21815525 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18391436 0,2180428 ! acute-phase response GO:0006953 42 27 0,000 0,18391436 0,21793047 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18391436 0,21781825 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18391436 0,21770614 ! natural killer cell activation GO:0030101 35 27 0,000 0,18391436 0,21759415 ! lipid oxidation GO:0034440 38 27 0,000 0,18391436 0,21748228 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18391436 0,21737052 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18391436 0,21725888 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,18391436 0,21714735 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,18391436 0,21703593 ! gene silencing GO:0016458 41 27 0,000 0,18391436 0,21692463 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,1900391 0,22403379 ! phenol metabolic process GO:0018958 44 28 0,000 0,1900391 0,22391902 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,1900391 0,22380436 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,1900391 0,22368983 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,1900391 0,22357541 ! cell junction assembly GO:0034329 56 28 0,000 0,1900391 0,2234611 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,1900391 0,22334692 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,1900391 0,22323285 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,1900391 0,2231189 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,1900391 0,22300506 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,1900391 0,22289134 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,1900391 0,22277774 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,1900391 0,22266425 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,1900391 0,22255088 ! mesoderm formation GO:0001707 46 28 0,000 0,1900391 0,22243762 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,1900391 0,22232448 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,1900391 0,22221145 ! BMP signaling pathway GO:0030509 40 28 0,000 0,1900391 0,22209854 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,1900391 0,22198574 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,1900391 0,22187306 ! placenta development GO:0001890 37 28 0,000 0,1900391 0,22176049 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,19611821 0,22873828 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19611821 0,22862234 ! ovulation cycle process GO:0022602 41 29 0,000 0,19611821 0,22850653 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19611821 0,22839083 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,19611821 0,22827525 ! mismatch repair GO:0006298 34 29 0,000 0,19611821 0,22815978 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,19611821 0,22804443 ! formation of primary germ layer GO:0001704 48 29 0,000 0,19611821 0,2279292 ! telencephalon development GO:0021537 52 29 0,000 0,19611821 0,22781408 ! eye morphogenesis GO:0048592 51 29 0,000 0,19611821 0,22769908 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19611821 0,2275842 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20215205 0,23446783 ! collagen metabolic process GO:0032963 40 30 0,000 0,20215205 0,23434965 ! organic anion transport GO:0015711 51 30 0,000 0,20215205 0,23423159 ! cholesterol transport GO:0030301 46 30 0,000 0,20215205 0,23411365 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,20215205 0,23399583 ! spliceosome assembly GO:0000245 49 30 0,000 0,20215205 0,23387812 ! spindle organization GO:0007051 37 30 0,000 0,20215205 0,23376054 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20215205 0,23364307 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20215205 0,23352572 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,20215205 0,23340849 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20215205 0,23329137 ! ovulation cycle GO:0042698 43 30 0,000 0,20215205 0,23317438 ! hindbrain development GO:0030902 45 30 0,000 0,20215205 0,2330575 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20215205 0,23294073 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20215205 0,23282409 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,20215205 0,23270756 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,20215205 0,23259115 ! negative regulation of secretion GO:0051048 49 31 0,000 0,20814093 0,23936207 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20814093 0,23924245 ! odontogenesis GO:0042476 50 31 0,000 0,20814093 0,23912295 ! segmentation GO:0035282 41 31 0,000 0,20814093 0,23900357 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,20814093 0,23888431 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,20814093 0,23876516 ! metanephros development GO:0001656 58 31 0,000 0,20814093 0,23864614 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20814093 0,23852723 ! cell fate specification GO:0001708 37 31 0,000 0,20814093 0,23840844 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,20814093 0,23828977 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,20814093 0,23817122 ! RNA modification GO:0009451 40 31 0,000 0,20814093 0,23805278 ! regulation of muscle development GO:0048634 48 32 0,000 0,21408521 0,24472961 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,21408521 0,24460804 ! meiosis I GO:0007127 52 32 0,000 0,21408521 0,24448658 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,21408521 0,24436525 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,21408521 0,24424404 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,21408521 0,24412295 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 0,000 0,21408521 0,24400197 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,21408521 0,24388112 ! cytokine production GO:0001816 44 32 0,000 0,21408521 0,24376039 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,21408521 0,24363977 ! vesicle localization GO:0051648 47 32 0,000 0,21408521 0,24351928 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,2199852 0,25010675 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,2199852 0,24998318 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,2199852 0,24985973 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,2199852 0,24973641 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,2199852 0,2496132 ! sister chromatid segregation GO:0000819 46 33 0,000 0,2199852 0,24949012 ! cell junction organization GO:0034330 63 33 0,000 0,2199852 0,24936716 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,2199852 0,24924431 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,2199852 0,24912159 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,2199852 0,248999 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,2199852 0,24887652 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,2199852 0,24875416 ! positive regulation of cell development GO:0010720 54 33 0,000 0,2199852 0,24863192 ! lipid homeostasis GO:0055088 55 33 0,000 0,2199852 0,2485098 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,2199852 0,24838781 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,2199852 0,24826593 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,2199852 0,24814417 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,22584123 0,25462492 ! mRNA catabolic process GO:0006402 48 34 0,000 0,22584123 0,25450017 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,22584123 0,25437553 ! feeding behavior GO:0007631 45 34 0,000 0,22584123 0,25425102 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,22584123 0,25412663 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,22584123 0,25400237 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,22584123 0,25387822 ! neuron migration GO:0001764 46 34 0,000 0,22584123 0,2537542 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,22584123 0,25363029 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,22584123 0,25350651 ! aerobic respiration GO:0009060 47 34 0,000 0,22584123 0,25338285 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,22584123 0,25325931 ! embryonic organ development GO:0048568 45 34 0,000 0,22584123 0,25313589 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,22584123 0,25301259 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,23165364 0,25939794 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,23165364 0,25927171 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,23165364 0,2591456 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,23165364 0,25901962 ! glycogen metabolic process GO:0005977 48 35 0,000 0,23165364 0,25889376 ! pigment metabolic process GO:0042440 61 35 0,000 0,23165364 0,25876802 ! protein homooligomerization GO:0051260 52 35 0,000 0,23165364 0,25864241 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,23742273 0,26495501 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,23742273 0,26482652 ! negative regulation of binding GO:0051100 58 36 0,000 0,23742273 0,26469815 ! organic ether metabolic process GO:0018904 46 36 0,000 0,23742273 0,2645699 ! tissue remodeling GO:0048771 62 36 0,000 0,23742273 0,26444178 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,23742273 0,26431378 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23742273 0,26418591 ! glucan metabolic process GO:0044042 49 36 0,000 0,23742273 0,26405816 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,24314883 0,27029595 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,24314883 0,27016537 ! regulation of protein secretion GO:0050708 51 37 0,000 0,24314883 0,27003492 ! amino acid activation GO:0043038 52 37 0,000 0,24314883 0,26990459 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,24314883 0,26977439 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,24883227 0,27594707 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,24883227 0,27581408 ! phagocytosis GO:0006909 60 38 0,000 0,24883227 0,27568122 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,25447335 0,28179523 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,25447335 0,28165962 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,25447335 0,28152414 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,25447335 0,2813888 ! male sex differentiation GO:0046661 53 39 0,000 0,25447335 0,28125358 ! chromatin remodeling GO:0006338 68 39 0,000 0,25447335 0,28111849 ! JNK cascade GO:0007254 54 39 0,000 0,25447335 0,28098353 ! cell growth GO:0016049 61 39 0,000 0,25447335 0,2808487 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,26007238 0,2868904 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,26007238 0,28675287 ! regulation of tube size GO:0035150 60 40 0,000 0,26007238 0,28661547 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,26007238 0,2864782 ! peptide metabolic process GO:0006518 56 40 0,000 0,26007238 0,28634106 ! inner ear development GO:0048839 57 40 0,000 0,26007238 0,28620406 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,26007238 0,28606718 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! positive regulation of protein transport GO:0051222 55 40 0,000 0,26007238 0,28593044 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,26562969 0,29190076 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,26562969 0,29176136 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,26562969 0,29162209 ! glucose transport GO:0015758 52 41 0,000 0,26562969 0,29148296 ! endosome transport GO:0016197 71 41 0,000 0,26562969 0,29134396 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,26562969 0,29120509 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,26562969 0,29106636 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,27114557 0,29696896 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,27114557 0,29682761 ! hexose transport GO:0008645 54 42 0,000 0,27114557 0,2966864 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,27114557 0,29654532 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,27114557 0,29640438 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,27114557 0,29626357 ! excretion GO:0007588 63 42 0,000 0,27114557 0,29612289 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,27114557 0,29598235 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,27114557 0,29584194 ! positive regulation of binding GO:0051099 59 43 0,000 0,27662034 0,30167225 ! leukocyte migration GO:0050900 60 43 0,000 0,27662034 0,30152928 ! neuromuscular process GO:0050905 79 43 0,000 0,27662034 0,30138644 ! tRNA processing GO:0008033 49 43 0,000 0,27662034 0,30124374 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,28205429 0,30701603 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,28205429 0,3068708 ! glycolysis GO:0006096 53 44 0,000 0,28205429 0,30672571 ! regulation of ion transport GO:0043269 57 44 0,000 0,28205429 0,30658075 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,28205429 0,30643593 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,28205429 0,30629125 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,28205429 0,30614671 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,28205429 0,3060023 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,28205429 0,30585803 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,28205429 0,30571389 ! RNA catabolic process GO:0006401 64 45 0,000 0,28744774 0,311413 ! positive regulation of defense response GO:0031349 59 45 0,000 0,28744774 0,31126638 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28744774 0,3111199 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,28744774 0,31097356 ! cell recognition GO:0008037 58 45 0,000 0,28744774 0,31082736 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,29280097 0,31646722 ! cell redox homeostasis GO:0045454 63 46 0,000 0,29280097 0,31631857 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,29280097 0,31617006 ! regulation of ossification GO:0030278 71 46 0,000 0,29280097 0,3160217 ! histone modification GO:0016570 68 46 0,000 0,29280097 0,31587347 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,29811429 0,3214547 ! endocrine system development GO:0035270 83 47 0,000 0,29811429 0,32130406 ! covalent chromatin modification GO:0016569 75 47 0,000 0,29811429 0,32115357 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,29811429 0,32100322 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,29811429 0,32085301 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,29811429 0,32070293 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,29811429 0,320553 ! chloride transport GO:0006821 67 48 0,000 0,303388 0,32607121 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,303388 0,32591891 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,303388 0,32576676 ! gastrulation GO:0007369 73 48 0,000 0,303388 0,32561474 ! heart morphogenesis GO:0003007 65 48 0,000 0,303388 0,32546287 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,303388 0,32531114 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,303388 0,32515955 ! regulation of endocytosis GO:0030100 63 48 0,000 0,303388 0,3250081 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,303388 0,32485679 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,30862238 0,3303078 ! sensory perception of smell GO:0007608 61 49 0,000 0,30862238 0,33015417 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,30862238 0,33000068 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,30862238 0,32984734 ! RNA elongation GO:0006354 62 49 0,000 0,30862238 0,32969413 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,30862238 0,32954107 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,30862238 0,32938815 ! cartilage development GO:0051216 70 49 0,000 0,30862238 0,32923537 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,31381772 0,33462251 ! lipid modification GO:0030258 73 50 0,000 0,31381772 0,33446745 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,31381772 0,33431253 ! positive regulation of secretion GO:0051047 71 51 0,000 0,31897432 0,33964859 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,31897432 0,33949141 GO:0010863|positive regulation of phospholipase C activity, ! adult behavior GO:0030534 80 51 0,000 0,31897432 0,33933439 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,31897432 0,33917751 ! transition metal ion transport GO:0000041 74 52 0,000 0,32409247 0,34446057 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,32409247 0,34430147 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,32409247 0,34414251 ! establishment of organelle localization GO:0051656 85 52 0,000 0,32409247 0,3439837 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,32917244 0,3492143 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,32917244 0,3490533 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,32917244 0,34889245 ! kidney development GO:0001822 90 53 0,000 0,32917244 0,34873174 ! single fertilization GO:0007338 59 53 0,000 0,32917244 0,34857118 ! cell projection assembly GO:0030031 76 53 0,000 0,32917244 0,34841077 ! amino acid transport GO:0006865 84 54 0,000 0,33421452 0,35358482 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,33421452 0,35342225 ! regulation of mitosis GO:0007088 84 54 0,000 0,33421452 0,35325983 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,33421452 0,35309756 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,33421452 0,35293544 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,33421452 0,35277347 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,33421452 0,35261165 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,33421452 0,35244997 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,33421452 0,35228845 ! exocytosis GO:0006887 74 55 0,000 0,33921899 0,35739976 ! mesoderm development GO:0007498 76 55 0,000 0,33921899 0,35723611 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,33921899 0,35707262 ! carbohydrate transport GO:0008643 74 57 0,000 0,34911621 0,36732263 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,34911621 0,36715468 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,34911621 0,36698687 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,34911621 0,36681922 ! camera-type eye development GO:0043010 88 57 0,000 0,34911621 0,36665173 ! secondary metabolic process GO:0019748 84 57 0,000 0,34911621 0,36648438 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,35400951 0,37145158 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,35400951 0,3712822 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,3588663 0,37620442 ! lung development GO:0030324 94 59 0,000 0,3588663 0,37603303 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,3588663 0,37586179 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,3588663 0,37569071 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,36368686 0,38056404 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,36368686 0,38039098 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,36368686 0,38021808 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,36368686 0,38004533 ! regulation of heart contraction GO:0008016 91 60 0,000 0,36368686 0,37987274 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,36368686 0,3797003 ! fertilization GO:0009566 68 60 0,000 0,36368686 0,37952803 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,36847144 0,38434663 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,36847144 0,3841724 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,36847144 0,38399833 ! urogenital system development GO:0001655 101 61 0,000 0,36847144 0,38382442 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,36847144 0,38365066 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,36847144 0,38347706 ! extracellular matrix organization GO:0030198 103 61 0,000 0,36847144 0,38330362 ! amine catabolic process GO:0009310 90 62 0,000 0,37322032 0,38806815 ! neurotransmitter transport GO:0006836 81 62 0,000 0,37322032 0,38789279 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,37322032 0,38771759 ! respiratory tube development GO:0030323 99 62 0,000 0,37322032 0,38754254 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,37322032 0,38736766 ! organelle localization GO:0051640 96 62 0,000 0,37322032 0,38719293 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,37793376 0,39190606 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,37793376 0,39172945 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,37793376 0,391553 ! regulation of lipase activity GO:0060191 109 63 0,000 0,37793376 0,3913767 ! appendage morphogenesis GO:0035107 93 64 0,000 0,38261202 0,39604305 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,38261202 0,39586489 ! hexose catabolic process GO:0019320 82 64 0,000 0,38261202 0,3956869 ! respiratory system development GO:0060541 100 64 0,000 0,38261202 0,39550906 ! adaptive immune response GO:0002250 94 64 0,000 0,38261202 0,39533138 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,38725537 0,39994942 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,38725537 0,39976991 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,39186406 0,40434605 ! antigen processing and presentation GO:0019882 96 66 0,000 0,39186406 0,40416473 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,39186406 0,40398357 ! acute inflammatory response GO:0002526 92 68 0,000 0,40097849 0,41319468 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,40097849 0,41300964 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,40097849 0,41282477 ! rhythmic process GO:0048511 105 68 0,000 0,40097849 0,41264006 ! inorganic anion transport GO:0015698 93 68 0,000 0,40097849 0,41245552 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,40548474 0,41690429 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,40995735 0,42131452 ! humoral immune response GO:0006959 86 70 0,000 0,40995735 0,42112635 ! eye development GO:0001654 111 70 0,000 0,40995735 0,42093835 ! amine transport GO:0015837 101 70 0,000 0,40995735 0,42075051 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,40995735 0,42056285 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,41439656 0,42492737 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,41439656 0,42473801 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,41439656 0,42454882 ! response to hypoxia GO:0001666 132 72 0,000 0,41880263 0,42887179 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,41880263 0,42868093 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,41880263 0,42849023 ! regulation of blood pressure GO:0008217 107 73 0,000 0,4231758 0,43277205 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,4231758 0,4325797 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,42751631 0,43682253 ! response to oxygen levels GO:0070482 137 74 0,000 0,42751631 0,43662856 ! digestion GO:0007586 97 74 0,000 0,42751631 0,43643476 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,43182441 0,44063715 ! amine biosynthetic process GO:0009309 97 76 0,000 0,43610033 0,444803 ! tRNA metabolic process GO:0006399 95 76 0,000 0,43610033 0,44460583 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,44034432 0,44873369 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,44034432 0,44853496 ! regulation of DNA binding GO:0051101 119 77 0,000 0,44034432 0,4483364 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,44034432 0,44813802 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,44455661 0,45222477 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,44455661 0,45202484 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,44873743 0,45607428 ! cellular respiration GO:0045333 107 79 0,000 0,44873743 0,45587283 ! regulation of lyase activity GO:0051339 133 79 0,000 0,44873743 0,45567157 ! chromatin assembly GO:0031497 102 80 0,000 0,45288703 0,45968233 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,45288703 0,45947956 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,45700562 0,46345367 ! mRNA transport GO:0051028 121 81 0,000 0,45700562 0,46324942 ! regulation of neurological system process GO:0031644 122 81 0,000 0,45700562 0,46304535 ! vitamin metabolic process GO:0006766 103 81 0,000 0,45700562 0,46284145 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,46515073 0,47088323 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,46515073 0,47067606 ! regulation of defense response GO:0031347 117 84 0,000 0,4691777 0,47454209 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,4691777 0,4743335 ! sterol metabolic process GO:0016125 120 84 0,000 0,4691777 0,4741251 ! rRNA metabolic process GO:0016072 107 85 0,000 0,47317459 0,47795413 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,47317459 0,47774431 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,47317459 0,47753468 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,4771416 0,48132705 ! nucleosome organization GO:0034728 114 87 0,000 0,48107897 0,4850862 ! cellular defense response GO:0006968 102 87 0,000 0,48107897 0,48487363 ! female pregnancy GO:0007565 130 87 0,000 0,48107897 0,48466124 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,48498691 0,48838436 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,48498691 0,48817063 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,48886564 0,49185957 ! hormone metabolic process GO:0042445 121 90 0,000 0,49271539 0,49551613 ! RNA localization GO:0006403 135 91 0,000 0,49653636 0,49914057 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,50032876 0,50273314 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,50032876 0,5025136 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,50409282 0,5060731 ! electron transport chain GO:0022900 123 94 0,000 0,50782873 0,50960126 ! regulation of binding GO:0051098 151 95 0,000 0,51153672 0,51309832 ! angiogenesis GO:0001525 149 95 0,000 0,51153672 0,51287465 ! carboxylic acid transport GO:0046942 147 95 0,000 0,51153672 0,51265118 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,51521698 0,51611457 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,51521698 0,51588988 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,51521698 0,51566538 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,51886972 0,51909541 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,52966487 0,52966487