pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6749-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 5,000 1,248E-08 2,871E-05 ! peptidyl-tyrosine modification GO:0018212 37 25 5,000 2,164E-08 2,488E-05 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 3,000 9,435E-08 7,233E-05 ! cellular response to insulin stimulus GO:0032869 52 34 5,000 1,557E-07 8,952E-05 ! positive regulation of inflammatory response GO:0050729 30 20 4,000 2,762E-07 1,27E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 3,000 3,358E-07 1,287E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 6,000 3,764E-07 1,237E-04 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 6,000 4,201E-07 1,208E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 4,286E-07 1,095E-04 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 5,889E-07 1,354E-04 ! response to insulin stimulus GO:0032868 63 43 5,000 6,687E-07 1,398E-04 ! positive regulation of phosphorylation GO:0042327 102 70 6,000 7,818E-07 1,498E-04 ! negative regulation of glucose import GO:0046325 14 11 3,000 8,696E-07 1,538E-04 GO:0010829|negative regulation of glucose transport, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 9,19E-07 1,51E-04 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of phosphorus metabolic process GO:0010562 107 72 6,000 9,491E-07 1,455E-04 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 6,000 1,043E-06 1,5E-04 ! cellular response to hormone stimulus GO:0032870 109 74 6,000 1,145E-06 1,55E-04 ! gland development GO:0048732 148 77 6,000 1,503E-06 1,921E-04 ! positive regulation of protein modification process GO:0031401 107 78 6,000 1,641E-06 1,987E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 1,863E-06 2,142E-04 ! cytokine-mediated signaling pathway GO:0019221 76 54 5,000 2,652E-06 2,905E-04 ! response to peptide hormone stimulus GO:0043434 84 57 5,000 3,661E-06 3,827E-04 ! regulation of binding GO:0051098 151 95 6,000 6,194E-06 6,194E-04 ! positive regulation of DNA replication GO:0045740 29 18 3,000 7,749E-06 7,426E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 7,749E-06 7,129E-04 ! regulation of glucose import GO:0046324 21 18 3,000 7,749E-06 6,855E-04 GO:0010827|regulation of glucose transport, ! regulation of T cell proliferation GO:0042129 58 38 4,000 8,045E-06 6,853E-04 ! Ras protein signal transduction GO:0007265 162 100 6,000 8,706E-06 7,151E-04 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 1,042E-05 8,267E-04 ! regulation of T cell differentiation GO:0045580 59 41 4,000 1,18E-05 9,048E-04 ! positive regulation of locomotion GO:0040017 35 20 3,000 1,213E-05 9E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of fat cell differentiation GO:0045598 9 7 2,000 1,313E-05 9,44E-04 ! neuroblast proliferation GO:0007405 13 7 2,000 1,313E-05 9,154E-04 ! regulation of chemotaxis GO:0050920 36 21 3,000 1,49E-05 1,008E-03 ! regulation of inflammatory response GO:0050727 60 44 4,000 1,681E-05 1,104E-03 ! regulation of mast cell proliferation GO:0070666 64 44 4,000 1,681E-05 1,074E-03 ! protein import into nucleus GO:0006606 118 74 5,000 1,688E-05 1,049E-03 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 1,811E-05 1,096E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 1,811E-05 1,068E-03 ! regulation of behavior GO:0050795 38 22 3,000 1,811E-05 1,041E-03 ! nuclear import GO:0051170 121 75 5,000 1,824E-05 1,023E-03 ! positive regulation of defense response GO:0031349 59 45 4,000 1,88E-05 1,029E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 2,09E-05 1,118E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,09E-05 1,093E-03 ! smoothened signaling pathway GO:0007224 8 8 2,000 2,09E-05 1,068E-03 ! regulation of smoothened signaling pathway GO:0008589 13 8 2,000 2,09E-05 1,045E-03 ! regulation of DNA binding GO:0051101 119 77 5,000 2,122E-05 1,039E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 4,000 2,332E-05 1,118E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 4,000 2,588E-05 1,215E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 4,000 2,588E-05 1,191E-03 ! regulation of lymphocyte differentiation GO:0045619 69 48 4,000 2,588E-05 1,167E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 2,601E-05 1,15E-03 ! protein localization in nucleus GO:0034504 133 80 5,000 2,642E-05 1,147E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 3,489E-05 1,486E-03 ! negative regulation of protein modification process GO:0031400 50 26 3,000 3,618E-05 1,513E-03 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 3,733E-05 1,533E-03 ! kidney development GO:0001822 90 53 4,000 4,213E-05 1,7E-03 ! mRNA polyadenylation GO:0006378 18 10 2,000 4,431E-05 1,757E-03 ! cytoplasmic sequestering of protein GO:0051220 14 10 2,000 4,431E-05 1,727E-03 ! regulation of T cell activation GO:0050863 128 89 5,000 4,843E-05 1,856E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 5,51E-05 2,078E-03 ! regulation of protein import into nucleus GO:0042306 53 29 3,000 5,651E-05 2,096E-03 ! RNA polyadenylation GO:0043631 19 11 2,000 6,06E-05 2,213E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 6,06E-05 2,178E-03 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 6,06E-05 2,144E-03 ! actin cytoskeleton reorganization GO:0031532 21 11 2,000 6,06E-05 2,112E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 6,06E-05 2,08E-03 GO:0042130|negative regulation of T cell proliferation, ! mRNA 3'-end processing GO:0031124 19 11 2,000 6,06E-05 2,05E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 6,202E-05 2,067E-03 ! mammary gland development GO:0030879 57 31 3,000 7,402E-05 2,432E-03 ! odontogenesis GO:0042476 50 31 3,000 7,402E-05 2,398E-03 ! leukocyte chemotaxis GO:0030595 43 31 3,000 7,402E-05 2,364E-03 GO:0060326|cell chemotaxis, ! ribosomal large subunit biogenesis GO:0042273 12 12 2,000 8,037E-05 2,532E-03 ! autonomic nervous system development GO:0048483 23 12 2,000 8,037E-05 2,498E-03 ! RNA 3'-end processing GO:0031123 20 12 2,000 8,037E-05 2,465E-03 ! urogenital system development GO:0001655 101 61 4,000 8,335E-05 2,522E-03 ! protein import GO:0017038 156 99 5,000 8,798E-05 2,628E-03 ! protein localization in organelle GO:0033365 161 100 5,000 9,304E-05 2,743E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 3,000 9,517E-05 2,771E-03 ! negative regulation of DNA binding GO:0043392 54 33 3,000 9,517E-05 2,736E-03 ! regulation of transcription factor activity GO:0051090 97 63 4,000 9,733E-05 2,764E-03 GO:0090046|regulation of transcription regulator activity, ! positive regulation of protein import into nucleus GO:0042307 23 13 2,000 1,039E-04 2,915E-03 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 2,000 1,039E-04 2,88E-03 ! cell cycle checkpoint GO:0000075 108 64 4,000 1,05E-04 2,874E-03 ! mitotic cell cycle checkpoint GO:0007093 63 34 3,000 1,073E-04 2,902E-03 ! dorsal/ventral pattern formation GO:0009953 44 34 3,000 1,073E-04 2,868E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 1,204E-04 3,183E-03 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 2,000 1,316E-04 3,439E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,316E-04 3,4E-03 ! negative regulation of binding GO:0051100 58 36 3,000 1,347E-04 3,442E-03 ! negative regulation of cell cycle process GO:0010948 24 15 2,000 1,636E-04 4,134E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 1,636E-04 4,089E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,636E-04 4,045E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,636E-04 4,002E-03 ! positive regulation of oxidoreductase activity GO:0051353 21 15 2,000 1,636E-04 3,96E-03 ! regulation of T-helper cell differentiation GO:0045622 23 15 2,000 1,636E-04 3,919E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,636E-04 3,879E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 1,636E-04 3,839E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,849E-04 4,296E-03 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 2,000 2,002E-04 4,606E-03 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 2,000 2,002E-04 4,56E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,002E-04 4,515E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 2,002E-04 4,472E-03 ! positive regulation of protein transport GO:0051222 55 40 3,000 2,043E-04 4,518E-03 ! negative regulation of growth GO:0045926 123 75 4,000 2,228E-04 4,881E-03 ! regulation of protein transport GO:0051223 114 76 4,000 2,371E-04 5,146E-03 GO:0070201|regulation of establishment of protein localization, ! signal complex assembly GO:0007172 29 17 2,000 2,419E-04 5,199E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 2,419E-04 5,151E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,419E-04 5,103E-03 ! proximal/distal pattern formation GO:0009954 25 17 2,000 2,419E-04 5,057E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 2,474E-04 5,127E-03 ! leukocyte migration GO:0050900 60 43 3,000 2,713E-04 5,57E-03 ! activation of caspase activity GO:0006919 65 43 3,000 2,713E-04 5,521E-03 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 2,713E-04 5,473E-03 ! T cell activation GO:0042110 134 79 4,000 2,843E-04 5,686E-03 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 2,000 2,887E-04 5,724E-03 ! gut development GO:0048565 26 18 2,000 2,887E-04 5,675E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 2,000 2,887E-04 5,627E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 2,887E-04 5,58E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 3,238E-04 6,206E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 3,41E-04 6,481E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 3,41E-04 6,428E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 3,41E-04 6,376E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 3,41E-04 6,325E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 3,41E-04 6,274E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 3,41E-04 6,224E-03 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 2,000 3,41E-04 6,175E-03 ! embryonic organ morphogenesis GO:0048562 23 19 2,000 3,41E-04 6,127E-03 ! regulation of defense response GO:0031347 117 84 4,000 3,782E-04 6,744E-03 ! endocrine system development GO:0035270 83 47 3,000 3,833E-04 6,781E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 3,995E-04 7,015E-03 ! regulation of protein localization GO:0032880 132 85 4,000 3,995E-04 6,962E-03 ! positive regulation of caspase activity GO:0043280 72 48 3,000 4,158E-04 7,19E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 78 49 3,000 4,502E-04 7,727E-03 ! maintenance of location GO:0051235 84 49 3,000 4,502E-04 7,67E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 4,63E-04 7,831E-03 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 2,000 4,63E-04 7,773E-03 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 2,000 4,63E-04 7,717E-03 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 4,63E-04 7,662E-03 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 1,000 5,243E-04 8,614E-03 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 1,000 5,243E-04 8,552E-03 ! regulation of collagen biosynthetic process GO:0032965 6 5 1,000 5,243E-04 8,492E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,243E-04 8,433E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 5,243E-04 8,374E-03 ! response to protozoan GO:0001562 9 5 1,000 5,243E-04 8,317E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 5,243E-04 8,26E-03 ! parathyroid gland development GO:0060017 8 5 1,000 5,243E-04 8,203E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 5,243E-04 8,148E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! epithelial cell proliferation GO:0050673 6 5 1,000 5,243E-04 8,093E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,243E-04 8,039E-03 ! neutrophil mediated immunity GO:0002446 6 5 1,000 5,243E-04 7,986E-03 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 1,000 5,243E-04 7,934E-03 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 1,000 5,243E-04 7,882E-03 ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 1,000 5,243E-04 7,831E-03 ! paraxial mesoderm development GO:0048339 9 5 1,000 5,243E-04 7,78E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,243E-04 7,73E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 5,243E-04 7,681E-03 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 8 5 1,000 5,243E-04 7,632E-03 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 5,243E-04 7,584E-03 ! negative regulation of multicellular organism growth GO:0040015 7 5 1,000 5,243E-04 7,537E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 5,243E-04 7,49E-03 ! enteric nervous system development GO:0048484 8 5 1,000 5,243E-04 7,444E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 5,243E-04 7,398E-03 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 5,243E-04 7,353E-03 GO:0007439|ectodermal gut development, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 1,000 5,243E-04 7,308E-03 ! receptor biosynthetic process GO:0032800 6 5 1,000 5,243E-04 7,264E-03 ! cellular anion homeostasis GO:0030002 6 5 1,000 5,243E-04 7,221E-03 GO:0055081|anion homeostasis, ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 5,25E-04 7,188E-03 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 2,000 5,333E-04 7,258E-03 ! ureteric bud development GO:0001657 32 22 2,000 5,333E-04 7,215E-03 ! protein tetramerization GO:0051262 39 22 2,000 5,333E-04 7,173E-03 ! cell fate commitment GO:0045165 141 92 4,000 5,751E-04 7,69E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 2,000 6,1E-04 8,11E-03 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 6,1E-04 8,063E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 6,1E-04 8,017E-03 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 6,1E-04 7,972E-03 ! osteoblast differentiation GO:0001649 40 23 2,000 6,1E-04 7,927E-03 ! response to molecule of bacterial origin GO:0002237 30 23 2,000 6,1E-04 7,882E-03 ! receptor metabolic process GO:0043112 37 24 2,000 6,934E-04 8,91E-03 ! negative regulation of cell development GO:0010721 56 24 2,000 6,934E-04 8,861E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 2,000 6,934E-04 8,812E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 6,934E-04 8,763E-03 ! regulation of response to external stimulus GO:0032101 139 96 4,000 6,984E-04 8,777E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 7,502E-04 9,378E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 7,827E-04 9,731E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 7,827E-04 9,678E-03 ! neuron adhesion GO:0007158 9 6 1,000 7,827E-04 9,627E-03 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 1,000 7,827E-04 9,575E-03 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 7,827E-04 9,525E-03 ! cGMP-mediated signaling GO:0019934 10 6 1,000 7,827E-04 9,475E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 7,827E-04 9,425E-03 ! ER overload response GO:0006983 7 6 1,000 7,827E-04 9,376E-03 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 7,827E-04 9,327E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 7,827E-04 9,279E-03 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 7,827E-04 9,232E-03 ! male sex determination GO:0030238 9 6 1,000 7,827E-04 9,185E-03 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 7,827E-04 9,138E-03 ! negative regulation of translational initiation GO:0045947 7 6 1,000 7,827E-04 9,092E-03 ! spindle checkpoint GO:0031577 14 6 1,000 7,827E-04 9,046E-03 ! regulation of collagen metabolic process GO:0010712 7 6 1,000 7,827E-04 9,001E-03 ! response to exogenous dsRNA GO:0043330 8 6 1,000 7,827E-04 8,956E-03 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 1,000 7,827E-04 8,912E-03 ! neutrophil homeostasis GO:0001780 6 6 1,000 7,827E-04 8,868E-03 ! salivary gland morphogenesis GO:0007435 11 6 1,000 7,827E-04 8,824E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 7,827E-04 8,781E-03 ! axonal fasciculation GO:0007413 9 6 1,000 7,827E-04 8,739E-03 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 1,000 7,827E-04 8,696E-03 GO:0045625|regulation of T-helper 1 cell differentiation, ! organ or tissue specific immune response GO:0002251 7 6 1,000 7,827E-04 8,655E-03 ! negative regulation of B cell activation GO:0050869 9 6 1,000 7,827E-04 8,613E-03 ! regulation of chromosome organization GO:0033044 35 25 2,000 7,838E-04 8,584E-03 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 7,838E-04 8,544E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 8,023E-04 8,704E-03 ! extracellular structure organization GO:0043062 156 99 4,000 8,031E-04 8,672E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 8,031E-04 8,631E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 8,569E-04 9,167E-03 ! regulation of cytokine biosynthetic process GO:0042035 76 58 3,000 8,569E-04 9,124E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 8,813E-04 9,341E-03 ! lung development GO:0030324 94 59 3,000 9,141E-04 9,644E-03 ! actin filament organization GO:0007015 95 59 3,000 9,141E-04 9,6E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 9,862E-04 0,01031018 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 9,862E-04 0,01026353 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 2,000 9,862E-04 0,0102173 ! extracellular matrix organization GO:0030198 103 61 3,000 1,036E-03 0,01068879 ! negative regulation of transferase activity GO:0051348 105 61 3,000 1,036E-03 0,01064107 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,091E-03 0,01114737 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,091E-03 0,01109805 ! lipoprotein transport GO:0042953 9 7 1,000 1,091E-03 0,01104916 ! spinal cord patterning GO:0021511 7 7 1,000 1,091E-03 0,0110007 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,091E-03 0,01095266 GO:0021940|positive regulation of granule cell precursor proliferation, ! protein heterooligomerization GO:0051291 10 7 1,000 1,091E-03 0,01090504 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,091E-03 0,01085783 ! B cell lineage commitment GO:0002326 17 7 1,000 1,091E-03 0,01081103 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,091E-03 0,01076463 ! T cell lineage commitment GO:0002360 12 7 1,000 1,091E-03 0,01071863 ! synaptic vesicle endocytosis GO:0048488 16 7 1,000 1,091E-03 0,01067302 ! response to tumor cell GO:0002347 12 7 1,000 1,091E-03 0,01062779 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 1,091E-03 0,01058295 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 1,091E-03 0,01053848 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 1,000 1,091E-03 0,01049439 ! muscle adaptation GO:0043500 12 7 1,000 1,091E-03 0,01045066 ! defense response to Gram-negative bacterium GO:0050829 9 7 1,000 1,091E-03 0,0104073 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,099E-03 0,01044177 ! regulation of B cell activation GO:0050864 42 28 2,000 1,099E-03 0,0103988 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 2,000 1,099E-03 0,01035618 ! positive regulation of T cell differentiation GO:0045582 39 28 2,000 1,099E-03 0,01031391 ! negative regulation of cell growth GO:0030308 106 62 3,000 1,102E-03 0,01029955 ! respiratory tube development GO:0030323 99 62 3,000 1,102E-03 0,01025785 ! positive regulation of T cell proliferation GO:0042102 44 29 2,000 1,219E-03 0,01130434 ! telencephalon development GO:0021537 52 29 2,000 1,219E-03 0,01125895 ! negative regulation of cell size GO:0045792 108 64 3,000 1,241E-03 0,01141418 ! respiratory system development GO:0060541 100 64 3,000 1,241E-03 0,01136871 ! regulation of caspase activity GO:0043281 97 65 3,000 1,315E-03 0,01199846 ! positive regulation of T cell activation GO:0050870 94 65 3,000 1,315E-03 0,01195104 ! protein oligomerization GO:0051259 100 65 3,000 1,315E-03 0,01190399 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 2,000 1,347E-03 0,01215061 ! spindle organization GO:0007051 37 30 2,000 1,347E-03 0,01210315 ! embryonic epithelial tube formation GO:0001838 44 30 2,000 1,347E-03 0,01205606 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,347E-03 0,01200933 ! axon guidance GO:0007411 99 66 3,000 1,392E-03 0,01235768 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,447E-03 0,01280072 ! succinate metabolic process GO:0006105 14 8 1,000 1,447E-03 0,01275167 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,447E-03 0,012703 ! keratinocyte proliferation GO:0043616 12 8 1,000 1,447E-03 0,0126547 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,447E-03 0,01260677 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,447E-03 0,01255919 ! L-phenylalanine metabolic process GO:0006558 8 8 1,000 1,447E-03 0,01251198 GO:0006559|L-phenylalanine catabolic process, ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,447E-03 0,01246512 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 1,447E-03 0,01241861 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! regulation of multicellular organismal metabolic process GO:0044246 9 8 1,000 1,447E-03 0,01237244 ! regulation of Notch signaling pathway GO:0008593 18 8 1,000 1,447E-03 0,01232662 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,447E-03 0,01228113 GO:0045685|regulation of glial cell differentiation, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,447E-03 0,01223598 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 1,447E-03 0,01219116 ! cerebellum morphogenesis GO:0021587 9 8 1,000 1,447E-03 0,01214667 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! regulation of T-helper 1 type immune response GO:0002825 9 8 1,000 1,447E-03 0,0121025 ! S phase GO:0051320 8 8 1,000 1,447E-03 0,01205865 GO:0000084|S phase of mitotic cell cycle, ! myeloid cell homeostasis GO:0002262 8 8 1,000 1,447E-03 0,01201511 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,447E-03 0,01197189 ! lamellipodium assembly GO:0030032 9 8 1,000 1,447E-03 0,01192898 ! regulation of embryonic development GO:0045995 16 8 1,000 1,447E-03 0,01188638 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 1,472E-03 0,01204547 ! maintenance of protein location in cell GO:0032507 60 31 2,000 1,484E-03 0,01209978 ! metanephros development GO:0001656 58 31 2,000 1,484E-03 0,01205703 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 2,000 1,628E-03 0,01318699 ! meiosis I GO:0007127 52 32 2,000 1,628E-03 0,01314072 ! peripheral nervous system development GO:0007422 53 32 2,000 1,628E-03 0,01309477 ! regulation of protein stability GO:0031647 48 32 2,000 1,628E-03 0,01304915 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 2,000 1,628E-03 0,01300384 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 2,000 1,782E-03 0,01417898 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! carbohydrate homeostasis GO:0033500 39 33 2,000 1,782E-03 0,01413009 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 2,000 1,782E-03 0,01408153 ! cytokinesis GO:0000910 52 33 2,000 1,782E-03 0,01403331 ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 1,824E-03 0,01431877 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 1,824E-03 0,01427007 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 1,852E-03 0,01443594 ! regulation of developmental growth GO:0048638 13 9 1,000 1,852E-03 0,01438717 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,852E-03 0,01433873 ! regulation of glycolysis GO:0006110 15 9 1,000 1,852E-03 0,01429061 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 1,852E-03 0,01424282 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 1,000 1,852E-03 0,01419534 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 1,852E-03 0,01414818 ! ventral spinal cord development GO:0021517 11 9 1,000 1,852E-03 0,01410134 ! positive regulation of survival gene product expression GO:0045885 13 9 1,000 1,852E-03 0,0140548 ! myeloid leukocyte mediated immunity GO:0002444 11 9 1,000 1,852E-03 0,01400856 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,852E-03 0,01396263 GO:0006600|creatine metabolic process, ! receptor clustering GO:0043113 15 9 1,000 1,852E-03 0,013917 ! motor axon guidance GO:0008045 14 9 1,000 1,852E-03 0,01387167 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,852E-03 0,01382663 ! hindbrain morphogenesis GO:0021575 12 9 1,000 1,852E-03 0,01378189 ! thymus development GO:0048538 15 9 1,000 1,852E-03 0,01373743 ! spleen development GO:0048536 15 9 1,000 1,852E-03 0,01369326 ! detection of calcium ion GO:0005513 13 9 1,000 1,852E-03 0,01364937 ! regulation of muscle adaptation GO:0043502 12 9 1,000 1,852E-03 0,01360576 ! defense response to Gram-positive bacterium GO:0050830 10 9 1,000 1,852E-03 0,01356243 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 1,852E-03 0,01351938 ! regulation of peptidase activity GO:0052547 106 72 3,000 1,921E-03 0,01397885 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 2,000 1,944E-03 0,01410223 ! neuron migration GO:0001764 46 34 2,000 1,944E-03 0,01405788 ! embryonic organ development GO:0048568 45 34 2,000 1,944E-03 0,01401381 ! regulation of blood pressure GO:0008217 107 73 3,000 2,021E-03 0,0145226 ! tube morphogenesis GO:0035239 118 73 3,000 2,021E-03 0,01447736 ! mitochondrion organization GO:0007005 104 73 3,000 2,021E-03 0,0144324 ! maintenance of protein location GO:0045185 65 35 2,000 2,115E-03 0,01505741 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 2,115E-03 0,01501094 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of lymphocyte activation GO:0051251 108 74 3,000 2,124E-03 0,01503167 ! regulation of ligase activity GO:0051340 114 75 3,000 2,231E-03 0,01574125 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 2,295E-03 0,0161392 GO:0090047|positive regulation of transcription regulator activity, ! tissue remodeling GO:0048771 62 36 2,000 2,295E-03 0,01609 ! neural tube development GO:0021915 50 36 2,000 2,295E-03 0,01604109 ! neuron fate specification GO:0048665 11 10 1,000 2,303E-03 0,01605386 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,303E-03 0,01600536 ! sulfate transport GO:0008272 12 10 1,000 2,303E-03 0,01595715 ! regulation of cell projection assembly GO:0060491 20 10 1,000 2,303E-03 0,01590923 ! hippocampus development GO:0021766 19 10 1,000 2,303E-03 0,0158616 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,303E-03 0,01581425 ! blood vessel remodeling GO:0001974 21 10 1,000 2,303E-03 0,01576718 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,303E-03 0,0157204 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 2,303E-03 0,01567389 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,303E-03 0,01562765 ! response to X-ray GO:0010165 16 10 1,000 2,303E-03 0,01558169 ! negative regulation of ossification GO:0030279 19 10 1,000 2,303E-03 0,01553599 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,303E-03 0,01549057 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,303E-03 0,01544541 ! response to dsRNA GO:0043331 18 10 1,000 2,303E-03 0,01540051 ! positive regulation of interleukin-6 production GO:0032755 13 10 1,000 2,303E-03 0,01535587 ! cranial nerve development GO:0021545 12 10 1,000 2,303E-03 0,01531149 ! salivary gland development GO:0007431 22 10 1,000 2,303E-03 0,01526736 ! positive regulation of acute inflammatory response GO:0002675 14 10 1,000 2,303E-03 0,01522349 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,303E-03 0,01517987 ! nitric oxide mediated signal transduction GO:0007263 17 10 1,000 2,303E-03 0,0151365 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,303E-03 0,01509337 GO:0043470|regulation of carbohydrate catabolic process, ! embryonic gut development GO:0048566 11 10 1,000 2,303E-03 0,01505049 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 2,000 2,484E-03 0,0161833 ! pigmentation GO:0043473 74 38 2,000 2,682E-03 0,01742786 ! maintenance of location in cell GO:0051651 69 38 2,000 2,682E-03 0,01737877 ! virus-host interaction GO:0019048 17 11 1,000 2,802E-03 0,01810135 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,802E-03 0,01805065 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 2,802E-03 0,01800023 ! focal adhesion formation GO:0048041 24 11 1,000 2,802E-03 0,01795009 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,802E-03 0,01790023 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 2,802E-03 0,01785064 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 2,802E-03 0,01780133 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 2,802E-03 0,01775229 ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,802E-03 0,01770352 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 1,000 2,802E-03 0,01765502 ! aromatic amino acid family catabolic process GO:0009074 13 11 1,000 2,802E-03 0,01760678 ! male genitalia development GO:0030539 13 11 1,000 2,802E-03 0,01755881 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,802E-03 0,01751109 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! forebrain development GO:0030900 131 80 3,000 2,823E-03 0,01759577 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 2,89E-03 0,01796795 ! chromatin remodeling GO:0006338 68 39 2,000 2,89E-03 0,01791952 ! regulation of cell cycle process GO:0010564 122 81 3,000 2,953E-03 0,01825797 ! positive regulation of cell activation GO:0050867 120 81 3,000 2,953E-03 0,01820902 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 3,000 3,087E-03 0,01898497 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 3,000 3,087E-03 0,01893434 ! detection of stimulus involved in sensory perception GO:0050906 50 40 2,000 3,108E-03 0,01901351 ! T cell differentiation GO:0030217 65 40 2,000 3,108E-03 0,01896308 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 3,108E-03 0,01891291 ! positive regulation of DNA binding GO:0043388 57 41 2,000 3,336E-03 0,02024434 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 3,346E-03 0,02025244 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 3,346E-03 0,02019928 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 1,000 3,346E-03 0,0201464 ! tyrosine metabolic process GO:0006570 14 12 1,000 3,346E-03 0,0200938 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,346E-03 0,02004147 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of interleukin-12 production GO:0032655 16 12 1,000 3,346E-03 0,01998942 ! cerebellum development GO:0021549 13 12 1,000 3,346E-03 0,01993763 ! gland morphogenesis GO:0022612 23 12 1,000 3,346E-03 0,01988611 ! response to gamma radiation GO:0010332 20 12 1,000 3,346E-03 0,01983486 ! rRNA metabolic process GO:0016072 107 85 3,000 3,514E-03 0,0207783 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 3,000 3,514E-03 0,02072503 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 3,514E-03 0,02067202 ! regulation of JAK-STAT cascade GO:0046425 61 42 2,000 3,573E-03 0,02096691 ! cellular component disassembly GO:0022411 64 42 2,000 3,573E-03 0,02091356 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 2,000 3,573E-03 0,02086048 ! cell cycle arrest GO:0007050 150 86 3,000 3,665E-03 0,02134107 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 3,665E-03 0,02128718 ! positive regulation of binding GO:0051099 59 43 2,000 3,821E-03 0,0221377 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 3,821E-03 0,02208207 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 3,821E-03 0,02202673 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 2,000 3,821E-03 0,02197166 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 3,936E-03 0,02257288 ! regulation of chemokine production GO:0032642 17 13 1,000 3,936E-03 0,02251673 ! lipid localization GO:0010876 24 13 1,000 3,936E-03 0,02246086 GO:0019915|lipid storage, ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 3,936E-03 0,02240526 ! endocrine pancreas development GO:0031018 19 13 1,000 3,936E-03 0,02234994 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 3,936E-03 0,02229489 ! exocrine system development GO:0035272 27 13 1,000 3,936E-03 0,02224011 ! regulation of exocytosis GO:0017157 17 13 1,000 3,936E-03 0,0221856 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 3,936E-03 0,02213136 ! genitalia development GO:0048806 15 13 1,000 3,936E-03 0,02207738 ! regulation of cellular pH GO:0030641 20 13 1,000 3,936E-03 0,02202366 ! regulation of acute inflammatory response GO:0002673 19 13 1,000 3,936E-03 0,02197021 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 1,000 3,936E-03 0,02191701 ! interphase GO:0051325 159 88 3,000 3,98E-03 0,02211044 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 4,079E-03 0,02260676 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 2,000 4,079E-03 0,02255242 ! detection of abiotic stimulus GO:0009582 58 44 2,000 4,079E-03 0,02249834 ! regulation of neurogenesis GO:0050767 153 89 3,000 4,144E-03 0,02280149 ! leukocyte differentiation GO:0002521 143 90 3,000 4,312E-03 0,02367232 ! cell maturation GO:0048469 60 45 2,000 4,347E-03 0,02380652 ! neuron maturation GO:0042551 21 14 1,000 4,57E-03 0,02496416 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,57E-03 0,02490501 ! limbic system development GO:0021761 25 14 1,000 4,57E-03 0,02484613 ! epidermis morphogenesis GO:0048730 29 14 1,000 4,57E-03 0,02478753 ! pituitary gland development GO:0021983 23 14 1,000 4,57E-03 0,02472921 ! cellular response to starvation GO:0009267 21 14 1,000 4,57E-03 0,02467116 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,57E-03 0,02461338 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 4,57E-03 0,02455587 ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,57E-03 0,02449863 ! regulation of T-helper 2 type immune response GO:0002828 21 14 1,000 4,57E-03 0,02444166 ! peptide hormone secretion GO:0030072 23 14 1,000 4,57E-03 0,02438495 ! regulation of ossification GO:0030278 71 46 2,000 4,626E-03 0,02462901 ! regulation of adaptive immune response GO:0002819 72 46 2,000 4,626E-03 0,02457213 ! negative regulation of immune system process GO:0002683 73 47 2,000 4,915E-03 0,02604853 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 4,915E-03 0,02598865 ! regulation of muscle contraction GO:0006937 69 48 2,000 5,215E-03 0,02751142 ! positive regulation of cytokine production GO:0001819 73 48 2,000 5,215E-03 0,02744847 ! metencephalon development GO:0022037 19 15 1,000 5,247E-03 0,02755466 ! negative regulation of hormone secretion GO:0046888 20 15 1,000 5,247E-03 0,0274919 ! skin development GO:0043588 25 15 1,000 5,247E-03 0,02742941 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,247E-03 0,02736722 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 1,000 5,247E-03 0,0273053 ! neuron recognition GO:0008038 22 15 1,000 5,247E-03 0,02724366 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 5,247E-03 0,0271823 ! peptide secretion GO:0002790 27 15 1,000 5,247E-03 0,02712122 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,247E-03 0,02706041 ! defense response to virus GO:0051607 27 15 1,000 5,247E-03 0,02699987 ! regulation of angiogenesis GO:0045765 94 49 2,000 5,526E-03 0,02836994 ! cartilage development GO:0051216 70 49 2,000 5,526E-03 0,02830675 ! positive regulation of growth GO:0045927 67 50 2,000 5,848E-03 0,0298879 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 5,848E-03 0,02982163 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 5,968E-03 0,03037009 ! hormone secretion GO:0046879 25 16 1,000 5,968E-03 0,03030305 ! bone remodeling GO:0046849 24 16 1,000 5,968E-03 0,0302363 ! endothelial cell migration GO:0043542 22 16 1,000 5,968E-03 0,03016985 ! diencephalon development GO:0021536 25 16 1,000 5,968E-03 0,03010369 ! neural crest cell migration GO:0001755 24 16 1,000 5,968E-03 0,03003781 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 5,968E-03 0,02997223 ! nerve development GO:0021675 18 16 1,000 5,968E-03 0,02990693 ! negative regulation of translation GO:0017148 22 16 1,000 5,968E-03 0,02984192 ! positive regulation of organelle organization GO:0010638 82 51 2,000 6,18E-03 0,03083445 ! regulation of translation GO:0006417 151 100 3,000 6,258E-03 0,0311569 ! aging GO:0007568 79 52 2,000 6,524E-03 0,0324089 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 1,000 6,732E-03 0,03336943 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 1,000 6,732E-03 0,03329767 ! cell-substrate junction assembly GO:0007044 39 17 1,000 6,732E-03 0,03322621 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,732E-03 0,03315506 ! actin filament bundle formation GO:0051017 26 17 1,000 6,732E-03 0,03308422 ! neuromuscular junction development GO:0007528 23 17 1,000 6,732E-03 0,03301368 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 6,732E-03 0,03294344 ! long-chain fatty acid transport GO:0015909 24 17 1,000 6,732E-03 0,03287349 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 6,732E-03 0,03280385 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 6,732E-03 0,03273449 ! aromatic compound catabolic process GO:0019439 22 17 1,000 6,732E-03 0,03266543 ! regulation of bone remodeling GO:0046850 90 53 2,000 6,879E-03 0,03330883 ! skeletal system morphogenesis GO:0048705 78 53 2,000 6,879E-03 0,03323885 ! regulation of mitosis GO:0007088 84 54 2,000 7,245E-03 0,034935 GO:0051783|regulation of nuclear division, ! DNA catabolic process GO:0006308 67 54 2,000 7,245E-03 0,03486191 ! detection of external stimulus GO:0009581 66 54 2,000 7,245E-03 0,03478913 ! regulation of tissue remodeling GO:0034103 91 54 2,000 7,245E-03 0,03471665 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 7,537E-03 0,03604126 ! positive regulation of translation GO:0045727 28 18 1,000 7,537E-03 0,03596649 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 7,537E-03 0,03589202 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 7,537E-03 0,03581786 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 7,537E-03 0,03574401 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 1,000 7,537E-03 0,03567046 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 7,537E-03 0,03559722 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 1,000 7,537E-03 0,03552427 ! pigmentation during development GO:0048066 31 18 1,000 7,537E-03 0,03545163 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 7,537E-03 0,03537928 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 7,537E-03 0,03530722 ! synaptic vesicle transport GO:0048489 33 18 1,000 7,537E-03 0,03523546 ! detection of chemical stimulus GO:0009593 26 18 1,000 7,537E-03 0,03516399 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,537E-03 0,03509281 ! hormone transport GO:0009914 27 18 1,000 7,537E-03 0,03502191 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 7,537E-03 0,0349513 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 7,537E-03 0,03488098 ! exocytosis GO:0006887 74 55 2,000 7,623E-03 0,03520566 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 8,012E-03 0,03692815 ! response to alkaloid GO:0043279 32 19 1,000 8,384E-03 0,03856618 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 8,384E-03 0,03848921 ! vesicle docking during exocytosis GO:0006904 24 19 1,000 8,384E-03 0,03841253 ! response to starvation GO:0042594 30 19 1,000 8,384E-03 0,03833617 ! sex determination GO:0007530 29 19 1,000 8,384E-03 0,0382601 ! response to lipopolysaccharide GO:0032496 26 19 1,000 8,384E-03 0,03818434 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 8,384E-03 0,03810888 ! renal system process GO:0003014 35 19 1,000 8,384E-03 0,03803371 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 8,384E-03 0,03795884 ! regulation of interleukin-6 production GO:0032675 22 19 1,000 8,384E-03 0,03788427 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 8,384E-03 0,03780998 ! aromatic amino acid family metabolic process GO:0009072 24 19 1,000 8,384E-03 0,03773599 ! protein stabilization GO:0050821 26 19 1,000 8,384E-03 0,03766229 ! developmental maturation GO:0021700 75 57 2,000 8,412E-03 0,0377161 ! activation of MAPK activity GO:0000187 84 59 2,000 9,248E-03 0,04138307 ! myeloid cell differentiation GO:0030099 85 59 2,000 9,248E-03 0,04130271 ! spinal cord development GO:0021510 31 20 1,000 9,271E-03 0,04132498 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 9,271E-03 0,04124505 ! pallium development GO:0021543 38 20 1,000 9,271E-03 0,04116542 ! collagen fibril organization GO:0030199 45 20 1,000 9,271E-03 0,0410861 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 9,271E-03 0,04100709 ! positive regulation of B cell activation GO:0050871 31 20 1,000 9,271E-03 0,04092838 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 9,271E-03 0,04084998 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 9,684E-03 0,0425861 GO:0035113|embryonic appendage morphogenesis, ! regulation of heart contraction GO:0008016 91 60 2,000 9,684E-03 0,04250483 ! regulation of homeostatic process GO:0032844 105 60 2,000 9,684E-03 0,04242386 ! meiosis GO:0007126 96 61 2,000 0,01013099 0,04429899 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01013099 0,04421493 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 0,01013099 0,04413119 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01019834 0,04434061 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 0,01019834 0,04425695 ! vesicle docking GO:0048278 27 21 1,000 0,01019834 0,04417361 ! phototransduction GO:0007602 25 21 1,000 0,01019834 0,04409057 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01019834 0,04400785 ! cell aging GO:0007569 32 21 1,000 0,01019834 0,04392544 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01019834 0,04384334 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01019834 0,04376154 ! regulation of vasoconstriction GO:0019229 31 21 1,000 0,01019834 0,04368005 ! fatty acid transport GO:0015908 30 21 1,000 0,01019834 0,04359886 ! platelet activation GO:0030168 28 21 1,000 0,01019834 0,04351797 ! positive regulation of protein secretion GO:0050714 26 21 1,000 0,01019834 0,04343738 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01019834 0,04335709 ! regulation of bone mineralization GO:0030500 29 21 1,000 0,01019834 0,04327709 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01059011 0,0448568 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01116485 0,04720432 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 0,01116485 0,04711771 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01116485 0,04703141 ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01116485 0,04694543 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01116485 0,04685976 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01116485 0,04677441 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01116485 0,04668936 ! appendage morphogenesis GO:0035107 93 64 2,000 0,0115441 0,04818771 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 94 65 2,000 0,01203908 0,05016281 GO:0060173|limb development, ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01203908 0,0500721 ! neuron fate commitment GO:0048663 32 23 1,000 0,01217007 0,05052556 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01217007 0,05043453 ! myelination GO:0042552 35 23 1,000 0,01217007 0,05034382 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01217007 0,05025343 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01217007 0,05016337 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01217007 0,05007364 ! interaction with host GO:0051701 37 23 1,000 0,01217007 0,04998422 ! regulation of biomineral formation GO:0070167 31 23 1,000 0,01217007 0,04989512 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,01217007 0,04980634 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01217007 0,04971787 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01306521 0,05328013 ! positive regulation of cell projection organization GO:0031346 39 24 1,000 0,0132134 0,05378907 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,0132134 0,05369404 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 1,000 0,0132134 0,05359934 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 1,000 0,0132134 0,05350497 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,0132134 0,05341094 ! neural crest cell development GO:0014032 39 24 1,000 0,0132134 0,05331723 GO:0014033|neural crest cell differentiation, ! base-excision repair GO:0006284 31 24 1,000 0,0132134 0,05322386 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,0132134 0,05313081 ! neurotransmitter secretion GO:0007269 32 24 1,000 0,0132134 0,05303809 ! inorganic anion transport GO:0015698 93 68 2,000 0,01359646 0,05448059 ! peptide transport GO:0015833 43 25 1,000 0,01429424 0,05717695 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01429424 0,05707768 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01429424 0,05697876 ! detection of light stimulus GO:0009583 30 25 1,000 0,01429424 0,05688018 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01429424 0,05678194 GO:0045840|positive regulation of mitosis, ! response to metal ion GO:0010038 103 70 2,000 0,0146955 0,05827525 ! regulation of catabolic process GO:0009894 106 70 2,000 0,0146955 0,05817495 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,01526336 0,0603191 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01541198 0,06080199 ! regulation of pH GO:0006885 36 26 1,000 0,01541198 0,06069787 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01584348 0,06229059 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,01643589 0,06450946 ! membrane docking GO:0022406 39 27 1,000 0,01656604 0,06490955 ! acute-phase response GO:0006953 42 27 1,000 0,01656604 0,06479915 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01656604 0,06468914 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01656604 0,0645795 ! response to inorganic substance GO:0010035 115 75 2,000 0,01765767 0,06871853 ! cell junction assembly GO:0034329 56 28 1,000 0,01775584 0,06898385 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01775584 0,06886752 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,01775584 0,06875158 ! mesoderm formation GO:0001707 46 28 1,000 0,01775584 0,06863604 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01775584 0,06852087 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01775584 0,0684061 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01775584 0,06829171 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01775584 0,0681777 ! placenta development GO:0001890 37 28 1,000 0,01775584 0,06806407 ! regulation of adenylate cyclase activity GO:0045761 131 77 2,000 0,01892887 0,07243994 ! mismatch repair GO:0006298 34 29 1,000 0,0189808 0,07251802 ! formation of primary germ layer GO:0001704 48 29 1,000 0,0189808 0,07239775 ! eye morphogenesis GO:0048592 51 29 1,000 0,0189808 0,07227789 ! regulation of cyclase activity GO:0031279 132 78 2,000 0,01958304 0,07444791 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,02024035 0,07681981 ! hindbrain development GO:0030902 45 30 1,000 0,02024035 0,07669325 ! regulation of cAMP biosynthetic process GO:0030817 136 79 2,000 0,0202496 0,07660209 ! regulation of lyase activity GO:0051339 133 79 2,000 0,0202496 0,07647631 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,02092855 0,07891095 GO:0010498|proteasomal protein catabolic process, ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02153392 0,0810606 ! negative regulation of secretion GO:0051048 49 31 1,000 0,02153392 0,08092814 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,02153392 0,08079612 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02153392 0,08066453 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02153392 0,08053337 ! cell fate specification GO:0001708 37 31 1,000 0,02153392 0,08040264 ! regulation of cAMP metabolic process GO:0030814 141 81 2,000 0,02161992 0,0805929 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02286096 0,08508126 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,02286096 0,08494381 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02286096 0,0848068 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02286096 0,08467024 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02286096 0,08453411 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 2,000 0,02303989 0,08505898 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 2,000 0,02303989 0,08492266 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02376849 0,08746804 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02422092 0,08899061 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02422092 0,08884868 ! ear morphogenesis GO:0042471 42 33 1,000 0,02422092 0,0887072 ! actomyosin structure organization GO:0031032 43 33 1,000 0,02422092 0,08856617 ! cell junction organization GO:0034330 63 33 1,000 0,02422092 0,08842559 ! lipid homeostasis GO:0055088 55 33 1,000 0,02422092 0,08828545 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,02422092 0,08814576 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02422092 0,08800651 ! Golgi vesicle transport GO:0048193 138 85 2,000 0,0245095 0,08891458 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 2,000 0,02526291 0,09150345 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02561325 0,09262654 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,02561325 0,09248113 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02561325 0,09233617 ! protein processing GO:0016485 114 88 2,000 0,02680691 0,0964881 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02703741 0,0971657 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,02703741 0,09701412 ! protein homooligomerization GO:0051260 52 35 1,000 0,02703741 0,09686301 ! reproductive developmental process GO:0003006 127 89 2,000 0,02759748 0,09871572 ! regulation of nucleotide metabolic process GO:0006140 150 89 2,000 0,02759748 0,09856243 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,02849287 0,1016025 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,02849287 0,10144522 ! learning GO:0007612 67 37 1,000 0,02997911 0,10657179 ! regulation of protein secretion GO:0050708 51 37 1,000 0,02997911 0,10640733 ! amino acid activation GO:0043038 52 37 1,000 0,02997911 0,10624337 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 2,000 0,0300433 0,10630705 ! sulfur metabolic process GO:0006790 118 92 2,000 0,0300433 0,10614375 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,03149559 0,11110409 ! monocarboxylic acid transport GO:0015718 62 38 1,000 0,03149559 0,11093394 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03149559 0,11076432 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,03304181 0,11602469 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,03304181 0,11584783 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03304181 0,1156715 ! male sex differentiation GO:0046661 53 39 1,000 0,03304181 0,1154957 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,03304181 0,11532045 ! JNK cascade GO:0007254 54 39 1,000 0,03304181 0,11514572 ! developmental growth GO:0048589 62 39 1,000 0,03304181 0,11497152 ! synapse organization GO:0050808 55 39 1,000 0,03304181 0,11479785 ! in utero embryonic development GO:0001701 147 96 2,000 0,03347661 0,11613303 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,03347661 0,11595813 ! protein maturation GO:0051604 129 96 2,000 0,03347661 0,11578376 ! response to light stimulus GO:0009416 153 96 2,000 0,03347661 0,11560991 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,03461726 0,11936987 ! response to calcium ion GO:0051592 58 40 1,000 0,03461726 0,11919118 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,03461726 0,11901301 ! regulation of tube size GO:0035150 60 40 1,000 0,03461726 0,11883538 GO:0050880|regulation of blood vessel size, ! double-strand break repair GO:0006302 67 40 1,000 0,03461726 0,11865828 ! B cell differentiation GO:0030183 62 40 1,000 0,03461726 0,1184817 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03461726 0,11830565 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,03461726 0,11813013 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03608097 0,12294257 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03608097 0,1227607 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03608097 0,12257937 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03608097 0,12239858 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03608097 0,12221831 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03608097 0,12203858 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03608097 0,12185938 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03608097 0,1216807 ! sleep GO:0030431 11 5 0,000 0,03608097 0,12150254 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03608097 0,12132491 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03608097 0,12114779 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03608097 0,12097119 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03608097 0,1207951 ! tongue development GO:0043586 6 5 0,000 0,03608097 0,12061953 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03608097 0,12044446 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03608097 0,12026991 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03608097 0,12009585 ! cobalt ion transport GO:0006824 9 5 0,000 0,03608097 0,11992231 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03608097 0,11974926 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03608097 0,11957671 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03608097 0,11940466 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03608097 0,1192331 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03608097 0,11906203 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03608097 0,11889146 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03608097 0,11872137 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03608097 0,11855177 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03608097 0,11838265 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03608097 0,11821401 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03608097 0,11804585 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03608097 0,11787818 ! malate metabolic process GO:0006108 7 5 0,000 0,03608097 0,11771097 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03608097 0,11754424 ! behavioral response to pain GO:0048266 7 5 0,000 0,03608097 0,11737799 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03608097 0,1172122 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03608097 0,11704688 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03608097 0,11688202 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03608097 0,11671763 ! mating behavior GO:0007617 6 5 0,000 0,03608097 0,1165537 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03608097 0,11639023 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03608097 0,11622722 ! rhythmic behavior GO:0007622 12 5 0,000 0,03608097 0,11606467 ! copulation GO:0007620 7 5 0,000 0,03608097 0,11590256 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03608097 0,11574091 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03608097 0,11557972 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03608097 0,11541896 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03608097 0,11525866 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03608097 0,1150988 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03608097 0,11493938 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03608097 0,11478041 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03608097 0,11462187 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03608097 0,11446377 ! lymph vessel development GO:0001945 7 5 0,000 0,03608097 0,11430611 ! endochondral ossification GO:0001958 12 5 0,000 0,03608097 0,11414888 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03608097 0,11399208 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03608097 0,11383571 ! anagen GO:0042640 6 5 0,000 0,03608097 0,11367977 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03608097 0,11352426 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03608097 0,11336917 ! nuclear migration GO:0007097 10 5 0,000 0,03608097 0,11321451 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03608097 0,11306027 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03608097 0,11290644 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03608097 0,11275304 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03608097 0,11260005 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03608097 0,11244747 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03608097 0,11229531 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03608097 0,11214356 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03608097 0,11199222 ! ovulation GO:0030728 6 5 0,000 0,03608097 0,11184129 ! microvillus organization GO:0032528 7 5 0,000 0,03608097 0,11169076 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03608097 0,11154064 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03608097 0,11139092 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03608097 0,1112416 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03608097 0,11109268 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03608097 0,11094417 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03608097 0,11079604 ! polyol catabolic process GO:0046174 7 5 0,000 0,03608097 0,11064831 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03608097 0,11050098 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03608097 0,11035404 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03608097 0,11020748 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03608097 0,11006132 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03608097 0,10991554 ! urea metabolic process GO:0019627 6 5 0,000 0,03608097 0,10977015 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03608097 0,10962515 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03608097 0,10948052 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03608097 0,10933628 ! neutrophil activation GO:0042119 5 5 0,000 0,03608097 0,10919242 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03608097 0,10904893 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03608097 0,10890582 ! response to food GO:0032094 5 5 0,000 0,03608097 0,10876309 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03608097 0,10862073 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain neuron development GO:0021884 7 5 0,000 0,03608097 0,10847874 ! melanosome organization GO:0032438 7 5 0,000 0,03608097 0,10833712 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03608097 0,10819587 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03608097 0,10805499 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03608097 0,10791448 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03608097 0,10777433 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03608097 0,10763455 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03608097 0,10749512 ! nucleoside transport GO:0015858 6 5 0,000 0,03608097 0,10735606 ! nucleoside salvage GO:0043174 7 5 0,000 0,03608097 0,10721736 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03608097 0,10707901 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03608097 0,10694103 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03608097 0,10680339 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03608097 0,10666611 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03608097 0,10652919 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03608097 0,10639261 ! depyrimidination GO:0045008 8 5 0,000 0,03608097 0,10625638 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03608097 0,10612051 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03608097 0,10598498 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03608097 0,10584979 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03608097 0,10571495 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03608097 0,10558045 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03608097 0,1054463 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03608097 0,10531248 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03608097 0,10517901 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03608097 0,10504587 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03608097 0,10491307 ! centrosome duplication GO:0051298 5 5 0,000 0,03608097 0,1047806 ! response to UV-C GO:0010225 6 5 0,000 0,03608097 0,10464847 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03608097 0,10451667 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03608097 0,1043852 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03608097 0,10425406 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03608097 0,10412326 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03608097 0,10399278 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03608097 0,10386262 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03608097 0,10373279 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03608097 0,10360329 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03608097 0,10347411 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03608097 0,10334525 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03608097 0,10321671 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03608097 0,10308849 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03608097 0,10296059 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03608097 0,10283301 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03608097 0,10270574 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03608097 0,10257878 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03608097 0,10245214 ! neural tube patterning GO:0021532 6 5 0,000 0,03608097 0,10232581 ! histone demethylation GO:0016577 9 5 0,000 0,03608097 0,1021998 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03608097 0,10207409 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03608097 0,10194869 GO:0032374|regulation of cholesterol transport, ! establishment of planar polarity GO:0001736 6 5 0,000 0,03608097 0,1018236 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03608097 0,10169882 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03608097 0,10157434 ! transcription termination GO:0006353 8 5 0,000 0,03608097 0,10145017 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03608097 0,1013263 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03608097 0,10120273 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03608097 0,10107946 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03608097 0,10095649 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03608097 0,10083382 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03608097 0,10071145 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03608097 0,10058938 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03608097 0,1004676 ! apical protein localization GO:0045176 6 5 0,000 0,03608097 0,10034611 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03608097 0,10022492 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03608097 0,10010402 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03608097 0,09998342 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03608097 0,0998631 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03608097 0,09974307 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03608097 0,09962333 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03608097 0,09950388 ! glial cell migration GO:0008347 10 5 0,000 0,03608097 0,09938471 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03608097 0,09926583 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03608097 0,09914723 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03608097 0,09902892 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03608097 0,09891089 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03608097 0,09879314 ! neural plate development GO:0001840 6 5 0,000 0,03608097 0,09867567 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03608097 0,09855847 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03608097 0,09844156 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03608097 0,09832492 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03608097 0,09820856 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03608097 0,09809248 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03608097 0,09797667 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03608097 0,09786113 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03608097 0,09774586 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03608097 0,09763087 ! spindle assembly GO:0051225 5 5 0,000 0,03608097 0,09751614 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03608097 0,09740168 GO:0022011|myelination in the peripheral nervous system, ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03608097 0,0972875 ! organ regeneration GO:0031100 7 5 0,000 0,03608097 0,09717358 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03608097 0,09705992 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03608097 0,09694654 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03608097 0,09683341 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03622143 0,09709709 ! glucose transport GO:0015758 52 41 1,000 0,03622143 0,09698405 ! endosome transport GO:0016197 71 41 1,000 0,03622143 0,09687128 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,03710534 0,09911997 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 2,000 0,03710534 0,09900498 ! mitochondrial transport GO:0006839 60 42 1,000 0,03785383 0,10088507 ! hexose transport GO:0008645 54 42 1,000 0,03785383 0,1007683 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,03785383 0,10065181 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,03785383 0,10053558 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,04120134 0,10929998 ! regulation of action potential GO:0001508 71 44 1,000 0,04120134 0,10917406 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,04291548 0,11358528 ! regulation of translational initiation GO:0006446 64 45 1,000 0,04291548 0,11345472 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,04291548 0,11332446 ! cell recognition GO:0008037 58 45 1,000 0,04291548 0,1131945 ! tRNA transcription GO:0009304 11 6 0,000 0,04314063 0,11365802 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04314063 0,11352797 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04314063 0,11339823 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04314063 0,11326878 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04314063 0,11313962 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04314063 0,11301076 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04314063 0,11288219 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04314063 0,11275392 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04314063 0,11262593 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04314063 0,11249824 ! prostate gland development GO:0030850 9 6 0,000 0,04314063 0,11237084 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04314063 0,11224372 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04314063 0,11211689 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04314063 0,11199035 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04314063 0,11186409 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04314063 0,11173812 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04314063 0,11161243 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04314063 0,11148702 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04314063 0,11136189 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04314063 0,11123705 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,04314063 0,11111248 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04314063 0,1109882 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04314063 0,11086419 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04314063 0,11074046 ! signal peptide processing GO:0006465 8 6 0,000 0,04314063 0,110617 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04314063 0,11049382 ! mRNA stabilization GO:0048255 15 6 0,000 0,04314063 0,11037091 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04314063 0,11024828 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04314063 0,11012591 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04314063 0,11000382 ! opsonization GO:0008228 8 6 0,000 0,04314063 0,109882 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04314063 0,10976045 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04314063 0,10963917 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04314063 0,10951815 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04314063 0,10939741 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04314063 0,10927693 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04314063 0,10915671 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04314063 0,10903676 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04314063 0,10891707 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04314063 0,10879764 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04314063 0,10867848 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04314063 0,10855957 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04314063 0,10844093 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04314063 0,10832254 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04314063 0,10820441 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04314063 0,10808654 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04314063 0,10796893 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04314063 0,10785157 ! thymic T cell selection GO:0045061 12 6 0,000 0,04314063 0,10773447 ! protein lipoylation GO:0009249 10 6 0,000 0,04314063 0,10761762 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04314063 0,10750103 ! pigment granule organization GO:0048753 11 6 0,000 0,04314063 0,10738468 ! drug transport GO:0015893 6 6 0,000 0,04314063 0,10726859 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04314063 0,10715275 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04314063 0,10703716 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04314063 0,10692182 ! histidine metabolic process GO:0006547 6 6 0,000 0,04314063 0,10680673 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04314063 0,10669188 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04314063 0,10657728 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04314063 0,10646293 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04314063 0,10634882 ! adenohypophysis development GO:0021984 10 6 0,000 0,04314063 0,10623496 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04314063 0,10612133 ! hyperosmotic response GO:0006972 8 6 0,000 0,04314063 0,10600796 ! microtubule nucleation GO:0007020 10 6 0,000 0,04314063 0,10589482 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04314063 0,10578193 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04314063 0,10566927 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04314063 0,10555686 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04314063 0,10544468 ! response to dietary excess GO:0002021 7 6 0,000 0,04314063 0,10533275 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04314063 0,10522105 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04314063 0,10510958 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04314063 0,10499836 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04314063 0,10488737 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04314063 0,10477661 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04314063 0,10466608 ! neuron apoptosis GO:0051402 8 6 0,000 0,04314063 0,10455579 ! organic alcohol transport GO:0015850 9 6 0,000 0,04314063 0,10444573 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04314063 0,10433591 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04314063 0,10422631 ! carnitine transport GO:0015879 8 6 0,000 0,04314063 0,10411694 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04314063 0,10400781 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04314063 0,1038989 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04314063 0,10379022 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04314063 0,10368176 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04314063 0,10357354 ! parturition GO:0007567 12 6 0,000 0,04314063 0,10346553 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04314063 0,10335776 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04314063 0,10325021 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04314063 0,10314288 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04314063 0,10303577 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04314063 0,10292889 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04314063 0,10282223 ! macrophage differentiation GO:0030225 10 6 0,000 0,04314063 0,10271578 ! astrocyte development GO:0014002 14 6 0,000 0,04314063 0,10260956 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04314063 0,10250356 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04314063 0,10239778 ! interaction with symbiont GO:0051702 8 6 0,000 0,04314063 0,10229221 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04314063 0,10218687 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04314063 0,10208174 ! eating behavior GO:0042755 6 6 0,000 0,04314063 0,10197682 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04314063 0,10187212 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04314063 0,10176764 ! response to copper ion GO:0046688 9 6 0,000 0,04314063 0,10166337 ! DNA topological change GO:0006265 8 6 0,000 0,04314063 0,10155931 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04314063 0,10145547 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04314063 0,10135184 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04314063 0,10124842 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04314063 0,10114521 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04314063 0,10104221 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04314063 0,10093942 ! gas homeostasis GO:0033483 11 6 0,000 0,04314063 0,10083684 ! hair follicle maturation GO:0048820 7 6 0,000 0,04314063 0,10073447 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04314063 0,1006323 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04314063 0,10053034 ! Schwann cell development GO:0014044 14 6 0,000 0,04314063 0,10042859 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04314063 0,10032705 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04314063 0,10022571 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04314063 0,10012457 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04314063 0,10002364 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04314063 0,09992291 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04314063 0,09982238 ! histone ubiquitination GO:0016574 7 6 0,000 0,04314063 0,09972206 ! regulation of meiosis GO:0040020 10 6 0,000 0,04314063 0,09962194 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04314063 0,09952201 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04314063 0,09942229 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04314063 0,09932277 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04314063 0,09922345 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04314063 0,09912432 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04314063 0,0990254 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04314063 0,09892667 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04314063 0,09882814 ! receptor internalization GO:0031623 9 6 0,000 0,04314063 0,0987298 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04314063 0,09863166 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04314063 0,09853371 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,04314063 0,09843596 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04314063 0,0983384 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04314063 0,09824104 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04314063 0,09814387 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04314063 0,09804689 ! midbrain development GO:0030901 6 6 0,000 0,04314063 0,0979501 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04314063 0,0978535 ! regulation of viral transcription GO:0046782 8 6 0,000 0,04314063 0,09775709 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04314063 0,09766087 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04314063 0,09756485 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04314063 0,09746901 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04314063 0,09737335 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04314063 0,09727789 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04314063 0,09718261 ! adult feeding behavior GO:0008343 6 6 0,000 0,04314063 0,09708752 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04314063 0,09699262 ! blastocyst growth GO:0001832 15 6 0,000 0,04314063 0,0968979 ! pigment granule transport GO:0051904 12 6 0,000 0,04314063 0,09680336 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04314063 0,09670901 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04314063 0,09661485 ! catecholamine transport GO:0051937 7 6 0,000 0,04314063 0,09652086 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04314063 0,09642706 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04314063 0,09633344 ! protein prenylation GO:0018342 10 6 0,000 0,04314063 0,09624001 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04314063 0,09614675 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04314063 0,09605368 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04314063 0,09596078 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04314063 0,09586807 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04314063 0,09577553 ! response to UV GO:0009411 75 46 1,000 0,04465591 0,09904398 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,04642217 0,10286222 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,04821377 0,10672924 ! gastrulation GO:0007369 73 48 1,000 0,04821377 0,10662661 ! heart morphogenesis GO:0003007 65 48 1,000 0,04821377 0,10652419 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,05003028 0,11043151 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,05014898 0,1105874 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05014898 0,11048148 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05014898 0,11037575 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05014898 0,11027023 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05014898 0,11016491 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05014898 0,11005979 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05014898 0,10995487 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05014898 0,10985016 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05014898 0,10974564 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05014898 0,10964131 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05014898 0,10953719 ! reproductive behavior GO:0019098 12 7 0,000 0,05014898 0,10943327 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05014898 0,10932954 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05014898 0,10922601 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05014898 0,10912267 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,05014898 0,10901953 ! oligopeptide transport GO:0006857 11 7 0,000 0,05014898 0,10891658 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05014898 0,10881383 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05014898 0,10871128 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05014898 0,10860891 ! RNA methylation GO:0001510 11 7 0,000 0,05014898 0,10850674 ! pericardium development GO:0060039 8 7 0,000 0,05014898 0,10840476 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05014898 0,10830297 ! fibril organization GO:0043206 13 7 0,000 0,05014898 0,10820137 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05014898 0,10809997 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05014898 0,10799875 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05014898 0,10789772 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05014898 0,10779688 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05014898 0,10769623 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05014898 0,10759577 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05014898 0,10749549 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05014898 0,1073954 ! chemosensory behavior GO:0007635 9 7 0,000 0,05014898 0,1072955 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05014898 0,10719578 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05014898 0,10709625 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05014898 0,1069969 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05014898 0,10689774 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05014898 0,10679876 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05014898 0,10669997 ! reflex GO:0060004 12 7 0,000 0,05014898 0,10660135 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05014898 0,10650292 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05014898 0,10640467 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05014898 0,1063066 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05014898 0,10620871 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05014898 0,10611101 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05014898 0,10601348 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05014898 0,10591613 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05014898 0,10581896 ! adrenal gland development GO:0030325 17 7 0,000 0,05014898 0,10572196 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05014898 0,10562515 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05014898 0,10552851 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05014898 0,10543205 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05014898 0,10533577 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05014898 0,10523966 ! endosome organization GO:0007032 10 7 0,000 0,05014898 0,10514372 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05014898 0,10504796 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05014898 0,10495238 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05014898 0,10485697 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05014898 0,10476173 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05014898 0,10466666 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05014898 0,10457177 ! galactose metabolic process GO:0006012 10 7 0,000 0,05014898 0,10447705 ! vesicle fusion GO:0006906 15 7 0,000 0,05014898 0,1043825 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05014898 0,10428812 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05014898 0,10419391 ! organ growth GO:0035265 11 7 0,000 0,05014898 0,10409988 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05014898 0,10400601 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05014898 0,10391231 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05014898 0,10381878 ! retinol metabolic process GO:0042572 9 7 0,000 0,05014898 0,10372542 ! behavioral fear response GO:0001662 13 7 0,000 0,05014898 0,10363222 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05014898 0,10353919 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05014898 0,10344633 ! rRNA modification GO:0000154 12 7 0,000 0,05014898 0,10335364 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05014898 0,10326111 ! response to UV-B GO:0010224 11 7 0,000 0,05014898 0,10316875 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05014898 0,10307655 ! intermediate filament organization GO:0045109 11 7 0,000 0,05014898 0,10298452 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05014898 0,10289265 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05014898 0,10280095 ! fibrinolysis GO:0042730 9 7 0,000 0,05014898 0,10270941 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05014898 0,10261803 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05014898 0,10252681 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05014898 0,10243576 ! response to tropane GO:0014073 13 7 0,000 0,05014898 0,10234487 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! melanosome localization GO:0032400 10 7 0,000 0,05014898 0,10225413 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05014898 0,10216356 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05014898 0,10207315 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05014898 0,1019829 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05014898 0,10189281 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05014898 0,10180288 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05014898 0,10171311 ! mast cell activation GO:0045576 9 7 0,000 0,05014898 0,10162349 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05014898 0,10153403 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05014898 0,10144473 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05014898 0,10135559 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05014898 0,1012666 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05014898 0,10117777 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05014898 0,1010891 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05014898 0,10100058 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05014898 0,10091222 GO:0002714|positive regulation of B cell mediated immunity, ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05014898 0,10082401 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05014898 0,10073595 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05014898 0,10064805 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05014898 0,1005603 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,05014898 0,1004727 ! diuresis GO:0030146 12 7 0,000 0,05014898 0,10038526 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05014898 0,10029797 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05014898 0,10021083 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05014898 0,10012384 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05014898 0,100037 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05014898 0,09995031 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05014898 0,09986378 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05014898 0,09977739 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05014898 0,09969115 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05014898 0,09960506 ! lymph node development GO:0048535 9 7 0,000 0,05014898 0,09951912 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05014898 0,09943333 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05014898 0,09934769 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05014898 0,09926219 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05014898 0,09917684 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05014898 0,09909163 ! ATP catabolic process GO:0006200 10 7 0,000 0,05014898 0,09900658 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05014898 0,09892167 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05014898 0,0988369 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05014898 0,09875228 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05014898 0,0986678 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05014898 0,09858347 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05014898 0,09849929 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05014898 0,09841524 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05014898 0,09833134 ! retina homeostasis GO:0001895 9 7 0,000 0,05014898 0,09824758 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05014898 0,09816397 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05014898 0,0980805 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05014898 0,09799716 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05014898 0,09791398 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05014898 0,09783093 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05014898 0,09774802 ! regulation of actin filament length GO:0030832 72 50 1,000 0,05187122 0,10101931 ! ear development GO:0043583 72 50 1,000 0,05187122 0,10093384 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05187122 0,10084852 ! positive regulation of secretion GO:0051047 71 51 1,000 0,05373615 0,10438611 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05373615 0,10429802 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,05373615 0,10421008 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,05373615 0,10412229 ! regulation of cellular component size GO:0032535 74 52 1,000 0,05562464 0,1076908 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05562464 0,10760023 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,05562464 0,1075098 ! establishment of organelle localization GO:0051656 85 52 1,000 0,05562464 0,10741954 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0571064 0,11018853 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0571064 0,11009617 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0571064 0,11000396 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0571064 0,10991191 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0571064 0,10982001 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0571064 0,10972826 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0571064 0,10963667 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0571064 0,10954523 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0571064 0,10945394 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,0571064 0,10936281 ! phosphate transport GO:0006817 10 8 0,000 0,0571064 0,10927182 ! N-glycan processing GO:0006491 12 8 0,000 0,0571064 0,10918099 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0571064 0,10909031 ! UTP metabolic process GO:0046051 8 8 0,000 0,0571064 0,10899978 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0571064 0,1089094 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0571064 0,10881916 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0571064 0,10872908 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,0571064 0,10863915 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0571064 0,10854936 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0571064 0,10845973 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0571064 0,10837024 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0571064 0,1082809 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0571064 0,10819171 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0571064 0,10810266 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0571064 0,10801376 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0571064 0,107925 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0571064 0,1078364 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0571064 0,10774793 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0571064 0,10765962 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0571064 0,10757144 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0571064 0,10748341 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0571064 0,10739553 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0571064 0,10730779 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0571064 0,10722019 ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0571064 0,10713273 ! melanin metabolic process GO:0006582 12 8 0,000 0,0571064 0,10704542 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0571064 0,10695825 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0571064 0,10687122 ! macrophage activation GO:0042116 12 8 0,000 0,0571064 0,10678433 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0571064 0,10669759 ! multicellular organism growth GO:0035264 14 8 0,000 0,0571064 0,10661098 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0571064 0,10652452 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0571064 0,10643819 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0571064 0,10635201 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0571064 0,10626596 ! ruffle organization GO:0031529 11 8 0,000 0,0571064 0,10618006 ! osteoblast development GO:0002076 13 8 0,000 0,0571064 0,10609429 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0571064 0,10600866 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0571064 0,10592317 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0571064 0,10583782 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0571064 0,1057526 GO:0007351|tripartite regional subdivision, ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0571064 0,10566752 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0571064 0,10558258 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0571064 0,10549778 ! brain morphogenesis GO:0048854 20 8 0,000 0,0571064 0,10541311 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0571064 0,10532857 ! segment specification GO:0007379 10 8 0,000 0,0571064 0,10524418 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0571064 0,10515991 ! cellular extravasation GO:0045123 11 8 0,000 0,0571064 0,10507578 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0571064 0,10499179 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0571064 0,10490793 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0571064 0,10482421 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0571064 0,10474061 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0571064 0,10465716 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0571064 0,10457383 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,0571064 0,10449064 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0571064 0,10440758 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0571064 0,10432465 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0571064 0,10424185 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0571064 0,10415918 ! icosanoid secretion GO:0032309 12 8 0,000 0,0571064 0,10407665 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0571064 0,10399424 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0571064 0,10391197 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0571064 0,10382983 ! intracellular lipid transport GO:0032365 13 8 0,000 0,0571064 0,10374781 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0571064 0,10366593 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0571064 0,10358417 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0571064 0,10350255 ! sterol catabolic process GO:0016127 9 8 0,000 0,0571064 0,10342105 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0571064 0,10333968 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0571064 0,10325844 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0571064 0,10317732 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0571064 0,10309634 ! prophase GO:0051324 11 8 0,000 0,0571064 0,10301548 ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0571064 0,10293474 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0571064 0,10285414 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0571064 0,10277365 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0571064 0,1026933 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0571064 0,10261307 ! hormone catabolic process GO:0042447 13 8 0,000 0,0571064 0,10253297 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0571064 0,10245299 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0571064 0,10237313 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0571064 0,1022934 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0571064 0,1022138 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0571064 0,10213432 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0571064 0,10205496 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0571064 0,10197572 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0571064 0,10189661 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0571064 0,10181762 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0571064 0,10173875 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0571064 0,10166001 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0571064 0,10158139 ! regulation of neurotransmitter levels GO:0001505 73 53 1,000 0,05753623 0,10226687 ! cell projection assembly GO:0030031 76 53 1,000 0,05753623 0,1021879 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,0594705 0,10554179 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0594705 0,10546041 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,0594705 0,10537916 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0594705 0,10529804 ! mesoderm development GO:0007498 76 55 1,000 0,06142702 0,10867857 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06401326 0,11316718 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06401326 0,11308026 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06401326 0,11299347 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06401326 0,11290682 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06401326 0,1128203 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06401326 0,11273392 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06401326 0,11264766 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06401326 0,11256154 ! GTP metabolic process GO:0046039 9 9 0,000 0,06401326 0,11247555 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06401326 0,11238969 ! social behavior GO:0035176 14 9 0,000 0,06401326 0,11230396 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06401326 0,11221837 ! artery development GO:0060840 19 9 0,000 0,06401326 0,1121329 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06401326 0,11204756 ! response to pain GO:0048265 16 9 0,000 0,06401326 0,11196236 ! protein complex disassembly GO:0043241 17 9 0,000 0,06401326 0,11187728 GO:0043624|cellular protein complex disassembly, ! lung alveolus development GO:0048286 17 9 0,000 0,06401326 0,11179233 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06401326 0,11170751 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06401326 0,11162282 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06401326 0,11153826 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06401326 0,11145382 ! protein targeting to ER GO:0045047 19 9 0,000 0,06401326 0,11136951 ! T cell selection GO:0045058 18 9 0,000 0,06401326 0,11128533 ! endoderm development GO:0007492 12 9 0,000 0,06401326 0,11120128 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06401326 0,11111736 GO:0006688|glycosphingolipid biosynthetic process, ! arginine catabolic process GO:0006527 10 9 0,000 0,06401326 0,11103356 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06401326 0,11094988 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06401326 0,11086634 ! V(D)J recombination GO:0033151 12 9 0,000 0,06401326 0,11078292 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06401326 0,11069962 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06401326 0,11061645 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06401326 0,11053341 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06401326 0,11045049 ! mannose metabolic process GO:0006013 9 9 0,000 0,06401326 0,11036769 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06401326 0,11028502 ! epithelial cell development GO:0002064 10 9 0,000 0,06401326 0,11020247 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06401326 0,11012004 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06401326 0,11003774 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06401326 0,10995556 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06401326 0,10987351 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06401326 0,10979157 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06401326 0,10970976 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06401326 0,10962807 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06401326 0,1095465 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06401326 0,10946505 ! DNA ligation GO:0006266 14 9 0,000 0,06401326 0,10938373 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06401326 0,10930252 ! response to amine stimulus GO:0014075 13 9 0,000 0,06401326 0,10922144 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06401326 0,10914047 ! erythrocyte development GO:0048821 11 9 0,000 0,06401326 0,10905963 ! renal water homeostasis GO:0003091 14 9 0,000 0,06401326 0,1089789 ! postreplication repair GO:0006301 11 9 0,000 0,06401326 0,1088983 ! mRNA cleavage GO:0006379 13 9 0,000 0,06401326 0,10881781 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06401326 0,10873744 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06401326 0,10865719 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06401326 0,10857706 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06401326 0,10849705 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06401326 0,10841716 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06401326 0,10833738 ! acid secretion GO:0046717 14 9 0,000 0,06401326 0,10825772 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06401326 0,10817818 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06401326 0,10809875 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06401326 0,10801944 ! purine base metabolic process GO:0006144 18 9 0,000 0,06401326 0,10794025 ! oocyte differentiation GO:0009994 12 9 0,000 0,06401326 0,10786117 GO:0048599|oocyte development, ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06401326 0,10778221 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06401326 0,10770336 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06401326 0,10762463 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06401326 0,10754602 ! blastocyst formation GO:0001825 12 9 0,000 0,06401326 0,10746752 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06401326 0,10738913 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06401326 0,10731086 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06401326 0,1072327 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06401326 0,10715466 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06401326 0,10707673 ! prepulse inhibition GO:0060134 14 9 0,000 0,06401326 0,10699891 ! embryonic placenta development GO:0001892 12 9 0,000 0,06401326 0,1069212 ! insulin secretion GO:0030073 17 9 0,000 0,06401326 0,10684361 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06401326 0,10676613 ! response to nicotine GO:0035094 16 9 0,000 0,06401326 0,10668877 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06401326 0,10661151 ! nucleus localization GO:0051647 15 9 0,000 0,06401326 0,10653437 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06401326 0,10645734 ! localization within membrane GO:0051668 15 9 0,000 0,06401326 0,10638042 ! carbohydrate transport GO:0008643 74 57 1,000 0,06540511 0,10861498 ! chromosome segregation GO:0007059 83 57 1,000 0,06540511 0,10853661 ! camera-type eye development GO:0043010 88 57 1,000 0,06540511 0,10845836 ! viral reproductive process GO:0022415 87 58 1,000 0,06742585 0,11172871 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,06946717 0,11502842 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07086991 0,11726676 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07086991 0,11718246 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07086991 0,11709828 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07086991 0,11701421 ! thyroid gland development GO:0030878 19 10 0,000 0,07086991 0,11693027 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07086991 0,11684645 ! synapsis GO:0007129 13 10 0,000 0,07086991 0,11676275 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07086991 0,11667917 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07086991 0,11659571 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07086991 0,11651237 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07086991 0,11642914 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07086991 0,11634604 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,07086991 0,11626305 ! phospholipid efflux GO:0033700 16 10 0,000 0,07086991 0,11618018 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07086991 0,11609744 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07086991 0,1160148 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07086991 0,11593229 ! pathogenesis GO:0009405 13 10 0,000 0,07086991 0,11584989 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07086991 0,11576761 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07086991 0,11568545 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07086991 0,1156034 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07086991 0,11552147 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07086991 0,11543966 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07086991 0,11535796 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07086991 0,11527638 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07086991 0,11519491 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07086991 0,11511356 ! B cell proliferation GO:0042100 14 10 0,000 0,07086991 0,11503232 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07086991 0,1149512 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07086991 0,11487019 ! forebrain cell migration GO:0021885 17 10 0,000 0,07086991 0,1147893 ! lipid digestion GO:0044241 15 10 0,000 0,07086991 0,11470851 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07086991 0,11462785 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07086991 0,11454729 ! UV protection GO:0009650 14 10 0,000 0,07086991 0,11446685 ! entry into host cell GO:0030260 20 10 0,000 0,07086991 0,11438653 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07086991 0,11430631 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07086991 0,11422621 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07086991 0,11414622 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07086991 0,11406634 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07086991 0,11398657 ! regulation of organ growth GO:0046620 11 10 0,000 0,07086991 0,11390692 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07086991 0,11382737 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07086991 0,11374794 ! embryonic axis specification GO:0000578 12 10 0,000 0,07086991 0,11366862 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07086991 0,11358941 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07086991 0,11351031 ! fucose catabolic process GO:0019317 16 10 0,000 0,07086991 0,11343131 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07086991 0,11335243 GO:0006305|DNA alkylation, ! protein sumoylation GO:0016925 12 10 0,000 0,07086991 0,11327366 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07086991 0,113195 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07086991 0,11311645 ! zymogen activation GO:0031638 14 10 0,000 0,07086991 0,113038 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07086991 0,11295967 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07086991 0,11288144 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07086991 0,11280332 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07086991 0,11272531 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07086991 0,11264741 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07086991 0,11256961 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07086991 0,11249193 ! detection of bacterium GO:0016045 10 10 0,000 0,07086991 0,11241434 ! activation of innate immune response GO:0002218 10 10 0,000 0,07086991 0,11233687 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07086991 0,1122595 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07086991 0,11218224 ! developmental induction GO:0031128 13 10 0,000 0,07086991 0,11210509 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07086991 0,11202804 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07086991 0,1119511 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07086991 0,11187426 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,07152866 0,11283671 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,07152866 0,11275937 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,07152866 0,11268214 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,07360994 0,1158815 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,07360994 0,11580223 ! amine catabolic process GO:0009310 90 62 1,000 0,0757106 0,11902555 ! neurotransmitter transport GO:0006836 81 62 1,000 0,0757106 0,11894425 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,0757106 0,11886306 ! organelle localization GO:0051640 96 62 1,000 0,0757106 0,11878198 ! rRNA transcription GO:0009303 17 11 0,000 0,07767673 0,12178355 ! respiratory burst GO:0045730 14 11 0,000 0,07767673 0,12170059 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07767673 0,12161775 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07767673 0,12153501 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07767673 0,12145239 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,07767673 0,12136989 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07767673 0,12128749 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,07767673 0,1212052 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07767673 0,12112303 ! mating GO:0007618 14 11 0,000 0,07767673 0,12104097 ! T cell proliferation GO:0042098 20 11 0,000 0,07767673 0,12095902 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07767673 0,12087718 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07767673 0,12079545 ! bone resorption GO:0045453 16 11 0,000 0,07767673 0,12071383 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07767673 0,12063232 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07767673 0,12055093 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07767673 0,12046964 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07767673 0,12038846 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07767673 0,12030739 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07767673 0,12022643 ! syncytium formation GO:0006949 15 11 0,000 0,07767673 0,12014558 ! plasma membrane organization GO:0007009 18 11 0,000 0,07767673 0,12006483 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07767673 0,1199842 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07767673 0,11990367 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07767673 0,11982325 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07767673 0,11974294 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07767673 0,11966274 ! adult heart development GO:0007512 11 11 0,000 0,07767673 0,11958264 ! temperature homeostasis GO:0001659 16 11 0,000 0,07767673 0,11950266 ! L-glutamate transport GO:0015813 16 11 0,000 0,07767673 0,11942277 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07767673 0,119343 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07767673 0,11926333 ! stem cell development GO:0048864 29 11 0,000 0,07767673 0,11918377 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07767673 0,11910431 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07767673 0,11902496 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07767673 0,11894572 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07767673 0,11886658 ! vasoconstriction GO:0042310 15 11 0,000 0,07767673 0,11878755 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07767673 0,11870862 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07767673 0,11862979 ! ribosome assembly GO:0042255 13 11 0,000 0,07767673 0,11855108 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07767673 0,11847246 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07767673 0,11839395 ! chromatin silencing GO:0006342 19 11 0,000 0,07767673 0,11831554 ! nucleosome positioning GO:0016584 13 11 0,000 0,07767673 0,11823724 ! T cell homeostasis GO:0043029 20 11 0,000 0,07767673 0,11815904 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07767673 0,11808095 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07767673 0,11800295 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07767673 0,11792506 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07767673 0,11784728 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07767673 0,11776959 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07767673 0,11769201 ! cholesterol efflux GO:0033344 19 11 0,000 0,07767673 0,11761453 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07767673 0,11753715 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07767673 0,11745988 ! germ cell migration GO:0008354 18 11 0,000 0,07767673 0,1173827 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07767673 0,11730563 ! defense response to fungus GO:0050832 12 11 0,000 0,07767673 0,11722866 ! lysogeny GO:0030069 18 11 0,000 0,07767673 0,11715178 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07767673 0,11707501 ! acrosome reaction GO:0007340 13 11 0,000 0,07767673 0,11699834 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07767673 0,11692177 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,07783026 0,11707625 ! viral reproduction GO:0016032 92 63 1,000 0,07783026 0,11699973 ! regulation of lipase activity GO:0060191 109 63 1,000 0,07783026 0,11692331 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,07996852 0,12005718 ! adaptive immune response GO:0002250 94 64 1,000 0,07996852 0,11997886 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,08212501 0,12313398 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,08212501 0,12305376 ! defense response to bacterium GO:0042742 73 65 1,000 0,08212501 0,12297365 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08212501 0,12289364 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,08429935 0,12606535 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,08429935 0,12598344 ! regulation of immune effector process GO:0002697 101 66 1,000 0,08429935 0,12590163 ! lactation GO:0007595 20 12 0,000 0,08443406 0,12602099 ! reproductive cellular process GO:0048610 14 12 0,000 0,08443406 0,12593926 ! tRNA modification GO:0006400 14 12 0,000 0,08443406 0,12585764 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08443406 0,12577613 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08443406 0,12569472 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08443406 0,12561341 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08443406 0,12553222 ! non-recombinational repair GO:0000726 19 12 0,000 0,08443406 0,12545112 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08443406 0,12537013 ! peroxisomal transport GO:0043574 21 12 0,000 0,08443406 0,12528925 ! cartilage condensation GO:0001502 18 12 0,000 0,08443406 0,12520847 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08443406 0,1251278 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08443406 0,12504722 ! heart looping GO:0001947 15 12 0,000 0,08443406 0,12496676 ! palate development GO:0060021 15 12 0,000 0,08443406 0,12488639 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08443406 0,12480613 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08443406 0,12472597 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08443406 0,12464592 ! arginine metabolic process GO:0006525 13 12 0,000 0,08443406 0,12456596 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08443406 0,12448611 ! methionine metabolic process GO:0006555 13 12 0,000 0,08443406 0,12440637 ! Golgi organization GO:0007030 18 12 0,000 0,08443406 0,12432672 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08443406 0,12424718 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08443406 0,12416774 ! monoamine transport GO:0015844 13 12 0,000 0,08443406 0,1240884 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08443406 0,12400916 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08443406 0,12393002 ! L-amino acid transport GO:0015807 20 12 0,000 0,08443406 0,12385098 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08443406 0,12377205 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08443406 0,12369321 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08443406 0,12361447 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08443406 0,12353584 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08443406 0,1234573 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08443406 0,12337887 ! histone acetylation GO:0016573 23 12 0,000 0,08443406 0,12330053 ! histone methylation GO:0016571 15 12 0,000 0,08443406 0,1232223 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08443406 0,12314416 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08443406 0,12306612 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08443406 0,12298818 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08443406 0,12291034 ! intestinal absorption GO:0050892 19 12 0,000 0,08443406 0,1228326 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08443406 0,12275496 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08443406 0,12267741 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08443406 0,12259996 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08443406 0,12252261 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08443406 0,12244536 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08443406 0,1223682 ! microspike assembly GO:0030035 23 12 0,000 0,08443406 0,12229115 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08443406 0,12221418 ! response to cold GO:0009409 14 12 0,000 0,08443406 0,12213732 ! acute inflammatory response GO:0002526 92 68 1,000 0,0887001 0,12822768 ! learning or memory GO:0007611 123 68 1,000 0,0887001 0,12814713 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,0887001 0,12806669 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,09092578 0,1311978 ! response to drug GO:0042493 108 69 1,000 0,09092578 0,13111555 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,09092578 0,13103339 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09114227 0,13126313 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09114227 0,13118099 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09114227 0,13109895 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,09114227 0,13101701 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09114227 0,13093518 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09114227 0,13085345 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09114227 0,13077182 ! organelle fusion GO:0048284 28 13 0,000 0,09114227 0,13069029 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09114227 0,13060886 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09114227 0,13052754 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09114227 0,13044631 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,09114227 0,13036519 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09114227 0,13028417 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09114227 0,13020324 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09114227 0,13012242 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09114227 0,1300417 ! NAD metabolic process GO:0019674 21 13 0,000 0,09114227 0,12996108 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09114227 0,12988056 ! bone mineralization GO:0030282 15 13 0,000 0,09114227 0,12980014 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09114227 0,12971982 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09114227 0,12963959 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09114227 0,12955947 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09114227 0,12947945 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,09114227 0,12939952 ! cellular pigmentation GO:0033059 24 13 0,000 0,09114227 0,12931969 ! tissue regeneration GO:0042246 21 13 0,000 0,09114227 0,12923997 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09114227 0,12916033 ! cofactor transport GO:0051181 19 13 0,000 0,09114227 0,1290808 ! NADP metabolic process GO:0006739 18 13 0,000 0,09114227 0,12900137 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09114227 0,12892203 ! gas transport GO:0015669 18 13 0,000 0,09114227 0,12884279 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09114227 0,12876365 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09114227 0,12868461 ! regulation of axon extension GO:0030516 23 13 0,000 0,09114227 0,12860566 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09114227 0,12852681 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,09114227 0,12844805 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09114227 0,1283694 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09114227 0,12829083 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09114227 0,12821237 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,09316785 0,13098169 ! humoral immune response GO:0006959 86 70 1,000 0,09316785 0,13090168 ! eye development GO:0001654 111 70 1,000 0,09316785 0,13082176 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,09542595 0,13391073 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09780171 0,13716094 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,09780171 0,13707736 ! superoxide anion generation GO:0042554 18 14 0,000 0,09780171 0,13699387 ! regulation of S phase GO:0033261 18 14 0,000 0,09780171 0,13691049 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09780171 0,13682721 ! myotube differentiation GO:0014902 21 14 0,000 0,09780171 0,13674404 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,09780171 0,13666096 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09780171 0,13657798 ! inositol metabolic process GO:0006020 20 14 0,000 0,09780171 0,13649511 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09780171 0,13641233 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09780171 0,13632966 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09780171 0,13624709 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09780171 0,13616461 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09780171 0,13608224 ! response to cAMP GO:0051591 19 14 0,000 0,09780171 0,13599996 ! startle response GO:0001964 21 14 0,000 0,09780171 0,13591779 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09780171 0,13583571 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09780171 0,13575374 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09780171 0,13567186 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09780171 0,13559008 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09780171 0,1355084 ! glycine metabolic process GO:0006544 22 14 0,000 0,09780171 0,13542682 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09780171 0,13534533 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09780171 0,13526394 ! regulation of heart rate GO:0002027 23 14 0,000 0,09780171 0,13518266 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09780171 0,13510147 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09780171 0,13502037 ! embryo implantation GO:0007566 27 14 0,000 0,09780171 0,13493938 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09780171 0,13485848 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09780171 0,13477768 ! axon cargo transport GO:0008088 27 14 0,000 0,09780171 0,13469697 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09780171 0,13461636 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09780171 0,13453585 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09780171 0,13445543 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,09780171 0,13437511 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09780171 0,13429489 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09780171 0,13421476 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09780171 0,13413473 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09780171 0,13405479 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09780171 0,13397495 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09780171 0,1338952 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09780171 0,13381555 ! muscle maintenance GO:0046716 19 14 0,000 0,09780171 0,13373599 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09780171 0,13365653 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09780171 0,13357716 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09780171 0,13349789 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09780171 0,13341871 ! cell killing GO:0001906 20 14 0,000 0,09780171 0,13333962 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09780171 0,13326063 ! cilium assembly GO:0042384 20 14 0,000 0,09780171 0,13318173 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10441274 0,14210018 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10441274 0,14201614 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10441274 0,14193221 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10441274 0,14184837 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,10441274 0,14176464 ! lipid phosphorylation GO:0046834 23 15 0,000 0,10441274 0,141681 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10441274 0,14159746 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10441274 0,14151402 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10441274 0,14143068 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10441274 0,14134744 ! adult walking behavior GO:0007628 25 15 0,000 0,10441274 0,14126429 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10441274 0,14118124 ! myoblast differentiation GO:0045445 27 15 0,000 0,10441274 0,14109829 ! centrosome cycle GO:0007098 16 15 0,000 0,10441274 0,14101544 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10441274 0,14093269 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10441274 0,14085003 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10441274 0,14076747 ! cerebral cortex development GO:0021987 29 15 0,000 0,10441274 0,140685 ! response to osmotic stress GO:0006970 22 15 0,000 0,10441274 0,14060263 ! vesicle coating GO:0006901 25 15 0,000 0,10441274 0,14052036 ! DNA integration GO:0015074 22 15 0,000 0,10441274 0,14043819 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,10441274 0,14035611 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10441274 0,14027412 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10441274 0,14019223 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10441274 0,14011044 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10441274 0,14002874 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10441274 0,13994714 ! biomineral formation GO:0031214 18 15 0,000 0,10441274 0,13986564 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10441274 0,13978422 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10441274 0,13970291 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10441274 0,13962168 ! organic cation transport GO:0015695 19 15 0,000 0,10441274 0,13954056 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10441274 0,13945952 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10441274 0,13937858 ! peptide hormone processing GO:0016486 19 15 0,000 0,10441274 0,13929774 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10441274 0,13921698 ! blood coagulation GO:0007596 116 75 1,000 0,10461175 0,13940152 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 1,000 0,10461175 0,1393208 ! tRNA metabolic process GO:0006399 95 76 1,000 0,10694485 0,14234557 ! sex differentiation GO:0007548 105 77 1,000 0,10929194 0,14538546 ! protein secretion GO:0009306 27 16 0,000 0,11097569 0,14753994 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11097569 0,14745471 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11097569 0,14736957 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11097569 0,14728453 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11097569 0,1471996 ! glial cell development GO:0021782 24 16 0,000 0,11097569 0,14711475 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11097569 0,14703001 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11097569 0,14694536 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11097569 0,14686082 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11097569 0,14677636 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11097569 0,14669201 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11097569 0,14660775 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11097569 0,14652359 ! fructose metabolic process GO:0006000 20 16 0,000 0,11097569 0,14643953 ! regulation of protein binding GO:0043393 27 16 0,000 0,11097569 0,14635556 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11097569 0,14627169 ! protein export from nucleus GO:0006611 24 16 0,000 0,11097569 0,14618791 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11097569 0,14610423 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11097569 0,14602065 ! DNA replication initiation GO:0006270 25 16 0,000 0,11097569 0,14593716 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11097569 0,14585377 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11097569 0,14577047 ! oogenesis GO:0048477 23 16 0,000 0,11097569 0,14568727 ! G1 phase GO:0051318 27 16 0,000 0,11097569 0,14560416 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11097569 0,14552115 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11097569 0,14543823 ! steroid catabolic process GO:0006706 22 16 0,000 0,11097569 0,14535541 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11097569 0,14527268 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11097569 0,14519004 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11097569 0,1451075 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11097569 0,14502506 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11097569 0,1449427 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11097569 0,14486044 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11097569 0,14477827 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,1116527 0,14557892 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11749093 0,15310433 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11749093 0,15301763 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11749093 0,15293104 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11749093 0,15284454 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11749093 0,15275813 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11749093 0,15267183 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11749093 0,15258562 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11749093 0,15249951 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11749093 0,1524135 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11749093 0,15232759 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,11749093 0,15224177 ! memory GO:0007613 25 17 0,000 0,11749093 0,15215605 ! keratinization GO:0031424 17 17 0,000 0,11749093 0,15207042 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11749093 0,15198489 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11749093 0,15189946 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11749093 0,15181412 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,11749093 0,15172888 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11749093 0,15164374 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11749093 0,15155869 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11749093 0,15147373 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11749093 0,15138887 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11749093 0,15130411 ! membrane budding GO:0006900 29 17 0,000 0,11749093 0,15121944 ! heme metabolic process GO:0042168 27 17 0,000 0,11749093 0,15113487 ! body fluid secretion GO:0007589 27 17 0,000 0,11749093 0,15105039 ! stem cell differentiation GO:0048863 36 17 0,000 0,11749093 0,150966 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11749093 0,15088171 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11749093 0,15079751 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11749093 0,15071341 ! sensory perception of pain GO:0019233 23 17 0,000 0,11749093 0,1506294 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11749093 0,15054548 GO:0002712|regulation of B cell mediated immunity, ! synaptogenesis GO:0007416 24 17 0,000 0,11749093 0,15046166 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,11749093 0,15037793 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11749093 0,15029429 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11749093 0,15021075 ! cell-cell junction organization GO:0045216 25 17 0,000 0,11749093 0,1501273 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,11749093 0,15004394 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11749093 0,14996068 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11749093 0,1498775 ! hemostasis GO:0007599 125 81 1,000 0,11881379 0,151481 ! mRNA transport GO:0051028 121 81 1,000 0,11881379 0,15139707 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12395879 0,15786557 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12395879 0,15777821 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12395879 0,15769094 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12395879 0,15760377 ! axis specification GO:0009798 26 18 0,000 0,12395879 0,15751669 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12395879 0,15742972 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12395879 0,15734283 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12395879 0,15725605 ! response to retinoic acid GO:0032526 25 18 0,000 0,12395879 0,15716936 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12395879 0,15708276 ! fucose metabolic process GO:0006004 26 18 0,000 0,12395879 0,15699626 ! response to fungus GO:0009620 19 18 0,000 0,12395879 0,15690986 ! peptide cross-linking GO:0018149 31 18 0,000 0,12395879 0,15682355 ! heart process GO:0003015 27 18 0,000 0,12395879 0,15673734 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12395879 0,15665122 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,12395879 0,15656519 ! somitogenesis GO:0001756 24 18 0,000 0,12395879 0,15647926 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12395879 0,15639343 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12395879 0,15630768 ! vitamin transport GO:0051180 24 18 0,000 0,12395879 0,15622204 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12395879 0,15613648 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12395879 0,15605102 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12395879 0,15596565 ! cell-cell recognition GO:0009988 20 18 0,000 0,12395879 0,15588038 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12395879 0,1557952 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12395879 0,15571011 ! transcription initiation GO:0006352 118 85 1,000 0,12853418 0,16136933 ! regulation of membrane potential GO:0042391 128 85 1,000 0,12853418 0,16128129 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13037961 0,16350769 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,13037961 0,16341859 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13037961 0,16332958 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13037961 0,16324067 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13037961 0,16315186 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,13037961 0,16306314 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,13037961 0,16297452 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13037961 0,16288599 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13037961 0,16279756 ! regeneration GO:0031099 32 19 0,000 0,13037961 0,16270923 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13037961 0,16262099 ! sensory perception of taste GO:0050909 23 19 0,000 0,13037961 0,16253285 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13037961 0,16244481 ! peroxisome organization GO:0007031 29 19 0,000 0,13037961 0,16235686 ! digestive system process GO:0022600 30 19 0,000 0,13037961 0,162269 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13037961 0,16218124 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13037961 0,16209357 ! response to vitamin A GO:0033189 26 19 0,000 0,13037961 0,162006 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13037961 0,16191853 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13037961 0,16183115 ! cytolysis GO:0019835 20 19 0,000 0,13037961 0,16174386 ! vasodilation GO:0042311 33 19 0,000 0,13037961 0,16165666 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13037961 0,16156956 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13037961 0,16148256 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13037961 0,16139565 ! sarcomere organization GO:0045214 23 19 0,000 0,13037961 0,16130883 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,13037961 0,1612221 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13037961 0,16113547 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13037961 0,16104893 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13037961 0,16096249 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,13037961 0,16087613 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,13346276 0,16459215 GO:0060538|skeletal muscle organ development, ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,13594313 0,1675612 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 1,000 0,13594313 0,16747145 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13675374 0,16837988 ! iron ion transport GO:0006826 37 20 0,000 0,13675374 0,16828979 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13675374 0,16819979 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13675374 0,16810989 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13675374 0,16802009 ! response to vitamin GO:0033273 29 20 0,000 0,13675374 0,16793038 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13675374 0,16784077 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,13675374 0,16775126 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13675374 0,16766184 ! response to ethanol GO:0045471 37 20 0,000 0,13675374 0,16757251 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13675374 0,16748328 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13675374 0,16739415 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13675374 0,16730511 ! chromosome condensation GO:0030261 31 20 0,000 0,13675374 0,16721617 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13675374 0,16712732 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,13675374 0,16703856 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13675374 0,1669499 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13675374 0,16686133 ! DNA modification GO:0006304 28 20 0,000 0,13675374 0,16677286 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13675374 0,16668448 ! collagen catabolic process GO:0030574 25 20 0,000 0,13675374 0,16659619 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13675374 0,166508 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13675374 0,1664199 ! alditol metabolic process GO:0019400 24 20 0,000 0,13675374 0,16633189 ! actin filament-based movement GO:0030048 34 20 0,000 0,13675374 0,16624398 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14308151 0,17384442 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14308151 0,17375263 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,14308151 0,17366094 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14308151 0,17356935 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14308151 0,17347785 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,14308151 0,17338645 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14308151 0,17329514 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14308151 0,17320394 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14308151 0,17311282 ! protein amino acid acylation GO:0043543 37 21 0,000 0,14308151 0,17302181 ! dendrite development GO:0016358 35 21 0,000 0,14308151 0,17293089 ! visual behavior GO:0007632 39 21 0,000 0,14308151 0,17284006 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14308151 0,17274933 ! ovarian follicle development GO:0001541 30 21 0,000 0,14308151 0,1726587 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14308151 0,17256816 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14308151 0,17247771 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14308151 0,17238736 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14308151 0,17229711 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14308151 0,17220695 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14308151 0,17211688 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14308151 0,17202691 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14308151 0,17193703 ! immunoglobulin production GO:0002377 33 21 0,000 0,14308151 0,17184725 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14308151 0,17175756 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14308151 0,17166796 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14308151 0,17157846 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,14308151 0,17148905 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14308151 0,17139973 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14308151 0,1713105 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14308151 0,17122137 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14308151 0,17113233 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14308151 0,17104339 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14308151 0,17095453 ! RNA localization GO:0006403 135 91 1,000 0,14344513 0,1713 ! response to virus GO:0009615 122 91 1,000 0,14344513 0,17121111 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,14849445 0,17714587 ! viral genome replication GO:0019079 29 22 0,000 0,14936326 0,17808994 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14936326 0,17799767 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14936326 0,17790549 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14936326 0,1778134 ! molting cycle process GO:0022404 40 22 0,000 0,14936326 0,17772142 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14936326 0,17762952 ! vasculogenesis GO:0001570 33 22 0,000 0,14936326 0,17753772 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,14936326 0,17744602 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14936326 0,17735441 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,14936326 0,1772629 ! lysosome organization GO:0007040 37 22 0,000 0,14936326 0,17717148 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,14936326 0,17708015 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,14936326 0,17698892 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14936326 0,17689778 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14936326 0,17680674 ! membrane depolarization GO:0051899 35 22 0,000 0,14936326 0,17671579 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14936326 0,17662493 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,14936326 0,17653417 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14936326 0,1764435 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14936326 0,17635292 ! blastocyst development GO:0001824 37 22 0,000 0,14936326 0,17626244 ! neural tube closure GO:0001843 33 22 0,000 0,14936326 0,17617205 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14936326 0,17608175 ! response to oxidative stress GO:0006979 141 94 1,000 0,15103269 0,1779586 ! angiogenesis GO:0001525 149 95 1,000 0,15357963 0,18086695 ! carboxylic acid transport GO:0046942 147 95 1,000 0,15357963 0,18077439 GO:0015849|organic acid transport, ! embryonic pattern specification GO:0009880 31 23 0,000 0,15559931 0,18305802 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15559931 0,18296443 ! vesicle targeting GO:0006903 32 23 0,000 0,15559931 0,18287093 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,15559931 0,18277754 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15559931 0,18268424 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,15559931 0,18259103 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,15559931 0,18249792 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15559931 0,1824049 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15559931 0,18231198 ! cell fate determination GO:0001709 45 23 0,000 0,15559931 0,18221915 ! pentose metabolic process GO:0019321 31 23 0,000 0,15559931 0,18212642 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15559931 0,18203378 ! spermatid development GO:0007286 33 23 0,000 0,15559931 0,18194124 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15559931 0,18184879 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15559931 0,18175643 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15559931 0,18166417 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15559931 0,181572 ! telomere organization GO:0032200 32 23 0,000 0,15559931 0,18147993 GO:0000723|telomere maintenance, ! regulation of amine transport GO:0051952 38 23 0,000 0,15559931 0,18138795 ! liver development GO:0001889 40 23 0,000 0,15559931 0,18129606 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,15613501 0,18182812 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,15869858 0,18472001 ! initiation of viral infection GO:0019059 42 24 0,000 0,16179 0,18822307 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16179 0,18812791 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,16179 0,18803285 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16179 0,18793788 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,16179 0,18784301 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16179 0,18774824 ! sperm motility GO:0030317 27 24 0,000 0,16179 0,18765356 ! vacuole organization GO:0007033 39 24 0,000 0,16179 0,18755898 ! response to toxin GO:0009636 38 24 0,000 0,16179 0,18746449 ! primary neural tube formation GO:0014020 35 24 0,000 0,16179 0,1873701 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16179 0,1872758 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16179 0,18718159 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16179 0,18708749 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16179 0,18699347 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,16643587 0,19226645 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,16793566 0,19390162 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,16793566 0,19380433 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16793566 0,19370713 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,16793566 0,19361004 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,16793566 0,19351304 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,16793566 0,19341614 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,16793566 0,19331933 ! male gonad development GO:0008584 33 25 0,000 0,16793566 0,19322262 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16793566 0,19312601 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,16793566 0,1930295 ! phospholipid transport GO:0015914 35 25 0,000 0,16793566 0,19293308 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,16793566 0,19283676 ! leukocyte proliferation GO:0070661 39 25 0,000 0,16793566 0,19274053 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17403661 0,19964299 ! translational initiation GO:0006413 43 26 0,000 0,17403661 0,19954347 ! circadian rhythm GO:0007623 42 26 0,000 0,17403661 0,19944405 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17403661 0,19934472 ! post-embryonic development GO:0009791 42 26 0,000 0,17403661 0,1992455 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17403661 0,19914637 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17403661 0,19904734 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17403661 0,19894841 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,17403661 0,19884958 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17403661 0,19875084 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17403661 0,19865221 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17403661 0,19855367 ! regulation of coagulation GO:0050818 39 26 0,000 0,17403661 0,19845523 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18009317 0,20525981 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,18009317 0,20515814 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18009317 0,20505658 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18009317 0,20495512 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18009317 0,20485375 ! catechol metabolic process GO:0009712 43 27 0,000 0,18009317 0,20475249 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18009317 0,20465133 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18009317 0,20455027 ! myofibril assembly GO:0030239 36 27 0,000 0,18009317 0,2044493 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18009317 0,20434844 ! natural killer cell activation GO:0030101 35 27 0,000 0,18009317 0,20424768 ! lipid oxidation GO:0034440 38 27 0,000 0,18009317 0,20414701 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18009317 0,20404645 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18009317 0,20394598 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,18009317 0,20384561 ! gene silencing GO:0016458 41 27 0,000 0,18009317 0,20374535 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18610566 0,21044396 ! phenol metabolic process GO:0018958 44 28 0,000 0,18610566 0,21034055 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,18610566 0,21023724 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18610566 0,21013403 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18610566 0,21003092 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18610566 0,20992792 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18610566 0,20982501 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18610566 0,20972221 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,18610566 0,2096195 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,18610566 0,2095169 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,18610566 0,2094144 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18610566 0,20931199 GO:0002764|immune response-regulating signal transduction, ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18610566 0,20920969 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18610566 0,20910749 ! BMP signaling pathway GO:0030509 40 28 0,000 0,18610566 0,20900538 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18610566 0,20890338 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,18610566 0,20880147 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,19207441 0,21539305 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19207441 0,21528808 ! ovulation cycle process GO:0022602 41 29 0,000 0,19207441 0,21518321 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19207441 0,21507845 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,19207441 0,21497379 ! muscle cell development GO:0055001 38 29 0,000 0,19207441 0,21486923 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,19207441 0,21476477 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19207441 0,21466042 ! tissue homeostasis GO:0001894 42 29 0,000 0,19207441 0,21455616 GO:0048871|multicellular organismal homeostasis, ! collagen metabolic process GO:0032963 40 30 0,000 0,19799972 0,22106765 ! organic anion transport GO:0015711 51 30 0,000 0,19799972 0,22096039 ! cholesterol transport GO:0030301 46 30 0,000 0,19799972 0,22085323 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,19799972 0,22074617 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19799972 0,22063922 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,19799972 0,22053238 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,19799972 0,22042563 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19799972 0,22031899 ! ovulation cycle GO:0042698 43 30 0,000 0,19799972 0,22021245 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19799972 0,22010602 ! adult locomotory behavior GO:0008344 47 30 0,000 0,19799972 0,21999969 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,19799972 0,21989346 ! response to heat GO:0009408 41 30 0,000 0,19799972 0,21978733 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,19799972 0,21968131 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19799972 0,21957539 ! glial cell differentiation GO:0010001 55 31 0,000 0,20388191 0,22598959 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,20388191 0,22588073 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20388191 0,22577198 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,20388191 0,22566333 ! segmentation GO:0035282 41 31 0,000 0,20388191 0,22555479 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,20388191 0,22544635 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20388191 0,22533801 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,20388191 0,22522978 ! RNA modification GO:0009451 40 31 0,000 0,20388191 0,22512165 ! regulation of muscle development GO:0048634 48 32 0,000 0,2097213 0,23145825 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,2097213 0,23134724 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,2097213 0,23123633 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,2097213 0,23112553 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 44 32 0,000 0,2097213 0,23101484 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,2097213 0,23090425 ! vesicle localization GO:0051648 47 32 0,000 0,2097213 0,23079377 ! RNA export from nucleus GO:0006405 44 33 0,000 0,21551819 0,2370597 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,21551819 0,23694638 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,21551819 0,23683317 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,21551819 0,23672007 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,21551819 0,23660708 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,21551819 0,23649419 ! female gonad development GO:0008585 49 33 0,000 0,21551819 0,23638141 ! positive regulation of cell development GO:0010720 54 33 0,000 0,21551819 0,23626874 ! regulation of proteolysis GO:0030162 50 33 0,000 0,21551819 0,23615618 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,21551819 0,23604373 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,21551819 0,23593138 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,21551819 0,23581914 ! mRNA catabolic process GO:0006402 48 34 0,000 0,22127288 0,24200077 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,22127288 0,24188575 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,22127288 0,24177084 ! feeding behavior GO:0007631 45 34 0,000 0,22127288 0,24165604 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,22127288 0,24154135 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,22127288 0,24142677 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,22127288 0,24131229 ! female gamete generation GO:0007292 43 34 0,000 0,22127288 0,24119793 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,22127288 0,24108367 ! polyol metabolic process GO:0019751 44 34 0,000 0,22127288 0,24096952 ! aerobic respiration GO:0009060 47 34 0,000 0,22127288 0,24085548 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,22127288 0,24074154 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,22698569 0,24684023 ! Notch signaling pathway GO:0007219 56 35 0,000 0,22698569 0,24672357 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,22698569 0,24660703 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,22698569 0,2464906 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,22698569 0,24637427 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,22698569 0,24625806 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,22698569 0,24614195 GO:0015986|ATP synthesis coupled proton transport, ! glycogen metabolic process GO:0005977 48 35 0,000 0,22698569 0,24602596 ! pigment metabolic process GO:0042440 61 35 0,000 0,22698569 0,24591007 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,23265691 0,25193545 ! organic ether metabolic process GO:0018904 46 36 0,000 0,23265691 0,25181689 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,23265691 0,25169845 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,23265691 0,25158011 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23265691 0,25146189 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,23265691 0,25134377 ! glucan metabolic process GO:0044042 49 36 0,000 0,23265691 0,25122577 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,23828685 0,25718431 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23828685 0,25706368 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23828685 0,25694316 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,23828685 0,25682275 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23828685 0,25670246 ! gliogenesis GO:0042063 71 38 0,000 0,2438758 0,26260035 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,2438758 0,26247747 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,2438758 0,2623547 ! phagocytosis GO:0006909 60 38 0,000 0,2438758 0,26223205 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,24942407 0,26807259 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,24942407 0,26794739 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,24942407 0,26782229 ! cell growth GO:0016049 61 39 0,000 0,24942407 0,26769732 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,25493193 0,27348108 ! peptide metabolic process GO:0006518 56 40 0,000 0,25493193 0,27335359 ! inner ear development GO:0048839 57 40 0,000 0,25493193 0,27322621 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,25493193 0,27309895 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! protein amino acid lipidation GO:0006497 62 41 0,000 0,2603997 0,27882649 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,2603997 0,27869674 ! striated muscle contraction GO:0006941 62 41 0,000 0,2603997 0,27856712 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,2603997 0,27843761 ! biopolymer methylation GO:0043414 62 41 0,000 0,2603997 0,27830822 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,2603997 0,27817896 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,26582764 0,28384567 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,26582764 0,28371396 ! excretion GO:0007588 63 42 0,000 0,26582764 0,28358236 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,26582764 0,28345089 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,26582764 0,28331955 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,26582764 0,28318832 ! regulation of cell shape GO:0008360 78 42 0,000 0,26582764 0,28305721 ! neuromuscular process GO:0050905 79 43 0,000 0,27121606 0,28866124 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,27121606 0,28852773 ! tRNA processing GO:0008033 49 43 0,000 0,27121606 0,28839434 ! vesicle organization GO:0016050 79 43 0,000 0,27121606 0,28826107 ! methylation GO:0032259 64 43 0,000 0,27121606 0,28812792 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,27656524 0,293675 ! glycolysis GO:0006096 53 44 0,000 0,27656524 0,29353948 ! regulation of ion transport GO:0043269 57 44 0,000 0,27656524 0,29340409 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,27656524 0,29326882 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,27656524 0,29313367 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,27656524 0,29299865 ! RNA catabolic process GO:0006401 64 45 0,000 0,28187547 0,29848691 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28187547 0,29834955 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,28714701 0,30378939 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,28714701 0,30364971 ! cell redox homeostasis GO:0045454 63 46 0,000 0,28714701 0,30351017 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,28714701 0,30337075 ! histone modification GO:0016570 68 46 0,000 0,28714701 0,30323146 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,29238016 0,30861605 ! viral infectious cycle GO:0019058 71 47 0,000 0,29238016 0,30847448 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,29238016 0,30833304 ! covalent chromatin modification GO:0016569 75 47 0,000 0,29238016 0,30819174 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,29238016 0,30805056 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,29238016 0,30790951 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,29238016 0,30776859 ! chloride transport GO:0006821 67 48 0,000 0,29757519 0,31309375 ! response to temperature stimulus GO:0009266 62 48 0,000 0,29757519 0,31295059 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,29757519 0,31280756 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,29757519 0,31266466 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,29757519 0,31252189 ! regulation of endocytosis GO:0030100 63 48 0,000 0,29757519 0,31237925 ! nuclear export GO:0051168 69 48 0,000 0,29757519 0,31223674 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,30273238 0,31750317 ! sensory perception of smell GO:0007608 61 49 0,000 0,30273238 0,31735846 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,30273238 0,31721388 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,30273238 0,31706943 ! RNA elongation GO:0006354 62 49 0,000 0,30273238 0,31692511 ! germ cell development GO:0007281 68 49 0,000 0,30273238 0,31678092 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,30273238 0,31663686 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,30273238 0,31649294 ! membrane fusion GO:0006944 80 50 0,000 0,30785199 0,32169904 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,30785199 0,32155294 ! lipid modification GO:0030258 73 50 0,000 0,30785199 0,32140698 ! proton transport GO:0015992 75 50 0,000 0,30785199 0,32126115 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,30785199 0,32111545 ! hydrogen transport GO:0006818 77 51 0,000 0,31293431 0,32626877 ! adult behavior GO:0030534 80 51 0,000 0,31293431 0,32612094 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,31293431 0,32597324 ! transition metal ion transport GO:0000041 74 52 0,000 0,31797959 0,3310788 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,31797959 0,33092899 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,32298812 0,33598945 ! single fertilization GO:0007338 59 53 0,000 0,32298812 0,33583756 ! amino acid transport GO:0006865 84 54 0,000 0,32796015 0,3408533 ! glucose catabolic process GO:0006007 66 54 0,000 0,32796015 0,34069934 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,33289595 0,34567074 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,33289595 0,34551475 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,33779578 0,35044217 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,3426599 0,35532812 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,3426599 0,35516799 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,3426599 0,355008 ! secondary metabolic process GO:0019748 84 57 0,000 0,3426599 0,35484816 ! gonad development GO:0008406 79 57 0,000 0,3426599 0,35468846 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,34748857 0,35952483 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,34748857 0,35936318 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,35228204 0,36415671 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,35704057 0,36890984 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,35704057 0,36874419 ! fertilization GO:0009566 68 60 0,000 0,35704057 0,36857869 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,36176441 0,37328764 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,36176441 0,37312025 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,36176441 0,372953 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,36645382 0,37761818 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,36645382 0,37744908 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,37110904 0,38207287 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,37573032 0,3866576 ! hexose catabolic process GO:0019320 82 64 0,000 0,37573032 0,38648467 ! reproductive structure development GO:0048608 90 65 0,000 0,3803179 0,39102869 ! activation of immune response GO:0002253 83 65 0,000 0,3803179 0,39085396 ! antigen processing and presentation GO:0019882 96 66 0,000 0,38487203 0,3953576 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,38487203 0,3951811 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,38939295 0,39964471 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,39388091 0,40407051 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,39388091 0,40389036 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,39388091 0,40371038 ! rhythmic process GO:0048511 105 68 0,000 0,39388091 0,40353055 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,39833613 0,40791322 ! amine transport GO:0015837 101 70 0,000 0,40275886 0,41225873 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,40275886 0,41207534 ! muscle cell differentiation GO:0042692 104 71 0,000 0,40714933 0,41638215 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,40714933 0,41619709 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,40714933 0,4160122 ! response to hypoxia GO:0001666 132 72 0,000 0,41150777 0,42027881 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,41150777 0,42009227 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,41583443 0,42432084 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,42012951 0,42851347 ! response to oxygen levels GO:0070482 137 74 0,000 0,42012951 0,42832353 ! digestion GO:0007586 97 74 0,000 0,42012951 0,42813375 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,42439327 0,43228721 ! amine biosynthetic process GO:0009309 97 76 0,000 0,42862591 0,43640531 ! response to unfolded protein GO:0006986 99 76 0,000 0,42862591 0,43621221 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,42862591 0,43601928 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,43282768 0,44009887 ! protein ubiquitination GO:0016567 125 77 0,000 0,43282768 0,4399044 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,43282768 0,43971009 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,43282768 0,43951596 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,43282768 0,439322 ! cellular respiration GO:0045333 107 79 0,000 0,44113945 0,44756097 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,44113945 0,44736364 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,44113945 0,44716647 ! chromatin assembly GO:0031497 102 80 0,000 0,44524989 0,45113425 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,44524989 0,4509356 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,44524989 0,45073713 ! response to protein stimulus GO:0051789 111 81 0,000 0,44933035 0,45466775 ! regulation of neurological system process GO:0031644 122 81 0,000 0,44933035 0,45446781 ! vitamin metabolic process GO:0006766 103 81 0,000 0,44933035 0,45426804 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,45740212 0,46222534 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,46139388 0,46605442 ! sterol metabolic process GO:0016125 120 84 0,000 0,46139388 0,46584983 ! nucleosome organization GO:0034728 114 87 0,000 0,47319515 0,47755544 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,47319515 0,47734598 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,47319515 0,47713671 ! female pregnancy GO:0007565 130 87 0,000 0,47319515 0,47692763 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,47319515 0,47671872 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,47707161 0,48041362 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,47707161 0,48020337 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,48091977 0,48386503 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,48473982 0,48749523 ! hormone metabolic process GO:0042445 121 90 0,000 0,48473982 0,48728217 ! ATP metabolic process GO:0046034 137 91 0,000 0,48853199 0,49087967 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,49229646 0,49444622 ! positive regulation of immune response GO:0050778 121 92 0,000 0,49229646 0,4942304 ! DNA recombination GO:0006310 146 92 0,000 0,49229646 0,49401477 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,49603344 0,49754771 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,49603344 0,49733082 ! electron transport chain GO:0022900 123 94 0,000 0,49974312 0,50083189 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,5070814 0,50796482 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,51071039 0,5113774 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,51788903 0,51833976 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,52143906 0,52166587 ! divalent metal ion transport GO:0070838 171 100 0,000 0,52143906 0,52143906