pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6749-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 5,000 5,811E-09 1,42E-05 ! peptidyl-tyrosine modification GO:0018212 57 28 5,000 9,421E-09 1,151E-05 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 3,000 3,227E-08 2,628E-05 ! cellular response to insulin stimulus GO:0032869 85 38 5,000 6,591E-08 4,025E-05 ! positive regulation of inflammatory response GO:0050729 41 21 4,000 9,651E-08 4,715E-05 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 6,000 1,206E-07 4,909E-05 ! induction of apoptosis by intracellular signals GO:0008629 95 45 5,000 1,883E-07 6,57E-05 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 3,000 1,911E-07 5,836E-05 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 6,000 1,964E-07 5,332E-05 ! negative regulation of phosphorylation GO:0042326 52 24 4,000 1,989E-07 4,858E-05 ! response to insulin stimulus GO:0032868 98 47 5,000 2,459E-07 5,461E-05 ! negative regulation of glucose import GO:0046325 18 11 3,000 2,99E-07 6,087E-05 GO:0010829|negative regulation of glucose transport, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 4,000 3,05E-07 5,731E-05 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of phosphorylation GO:0042327 149 81 6,000 3,673E-07 6,409E-05 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 6,000 4,344E-07 7,076E-05 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 164 85 6,000 5,116E-07 7,812E-05 ! cellular response to hormone stimulus GO:0032870 182 85 6,000 5,116E-07 7,353E-05 ! ribosomal large subunit biogenesis GO:0042273 13 13 3,000 6,422E-07 8,715E-05 ! positive regulation of protein modification process GO:0031401 156 90 6,000 7,565E-07 9,727E-05 ! gland development GO:0048732 220 91 6,000 8,157E-07 9,964E-05 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 3,000 8,951E-07 1,041E-04 ! cytokine-mediated signaling pathway GO:0019221 112 61 5,000 1,192E-06 1,323E-04 ! response to peptide hormone stimulus GO:0043434 129 64 5,000 1,587E-06 1,686E-04 ! regulation of T cell differentiation GO:0045580 78 42 4,000 3,669E-06 3,735E-04 ! regulation of T cell proliferation GO:0042129 80 43 4,000 4,133E-06 4,039E-04 ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 4,22E-06 3,966E-04 ! regulation of glucose import GO:0046324 30 20 3,000 4,22E-06 3,819E-04 GO:0010827|regulation of glucose transport, ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 4,642E-06 4,05E-04 ! positive regulation of locomotion GO:0040017 44 22 3,000 6,317E-06 5,321E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! protein import into nucleus GO:0006606 174 82 5,000 6,821E-06 5,555E-04 ! positive regulation of defense response GO:0031349 88 48 4,000 7,188E-06 5,664E-04 ! regulation of inflammatory response GO:0050727 84 48 4,000 7,188E-06 5,487E-04 ! nuclear import GO:0051170 177 83 5,000 7,319E-06 5,418E-04 ! positive regulation of DNA replication GO:0045740 44 23 3,000 7,613E-06 5,47E-04 ! regulation of chemotaxis GO:0050920 45 23 3,000 7,613E-06 5,314E-04 ! regulation of lymphocyte differentiation GO:0045619 92 49 4,000 7,968E-06 5,407E-04 ! regulation of mast cell proliferation GO:0070666 89 49 4,000 7,968E-06 5,261E-04 ! induction of apoptosis by extracellular signals GO:0008624 99 50 4,000 8,814E-06 5,666E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 9,34E-06 5,851E-04 ! protein import into nucleus, translocation GO:0000060 51 25 3,000 1,078E-05 6,585E-04 ! regulation of behavior GO:0050795 48 25 3,000 1,078E-05 6,424E-04 ! regulation of DNA binding GO:0051101 167 89 5,000 1,096E-05 6,375E-04 ! protein localization in nucleus GO:0034504 192 89 5,000 1,096E-05 6,227E-04 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 4,000 1,178E-05 6,539E-04 ! regulation of leukocyte proliferation GO:0070663 97 53 4,000 1,178E-05 6,394E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! osteoblast differentiation GO:0001649 63 26 3,000 1,269E-05 6,737E-04 ! induction of positive chemotaxis GO:0050930 17 9 2,000 1,395E-05 7,253E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 1,483E-05 7,547E-04 ! regulation of DNA replication GO:0006275 105 56 4,000 1,547E-05 7,711E-04 ! regulation of T cell activation GO:0050863 175 96 5,000 1,693E-05 8,272E-04 ! regulation of fibroblast proliferation GO:0048145 56 28 3,000 1,722E-05 8,25E-04 ! negative regulation of protein modification process GO:0031400 66 28 3,000 1,722E-05 8,092E-04 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 1,796E-05 8,28E-04 ! positive regulation of cell migration GO:0030335 137 58 4,000 1,839E-05 8,318E-04 ! smoothened signaling pathway GO:0007224 18 10 2,000 1,985E-05 8,817E-04 ! regulation of fat cell differentiation GO:0045598 18 10 2,000 1,985E-05 8,66E-04 ! kidney development GO:0001822 133 60 4,000 2,172E-05 9,308E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 2,718E-05 1,145E-03 ! regulation of smoothened signaling pathway GO:0008589 27 11 2,000 2,718E-05 1,126E-03 ! neuroblast proliferation GO:0007405 25 11 2,000 2,718E-05 1,107E-03 ! regulation of protein import into nucleus GO:0042306 69 32 3,000 2,973E-05 1,191E-03 ! positive regulation of cell motion GO:0051272 157 65 4,000 3,211E-05 1,265E-03 ! leukocyte chemotaxis GO:0030595 55 33 3,000 3,368E-05 1,306E-03 GO:0060326|cell chemotaxis, ! regulation of positive chemotaxis GO:0050926 22 12 2,000 3,61E-05 1,378E-03 GO:0050927|positive regulation of positive chemotaxis, ! mRNA polyadenylation GO:0006378 24 12 2,000 3,61E-05 1,357E-03 ! autonomic nervous system development GO:0048483 24 12 2,000 3,61E-05 1,336E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 3,61E-05 1,316E-03 GO:0042130|negative regulation of T cell proliferation, ! urogenital system development GO:0001655 149 69 4,000 4,291E-05 1,542E-03 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 2,000 4,673E-05 1,655E-03 ! mRNA 3'-end processing GO:0031124 25 13 2,000 4,673E-05 1,631E-03 ! cytoplasmic sequestering of protein GO:0051220 25 13 2,000 4,673E-05 1,608E-03 ! negative regulation of DNA binding GO:0043392 67 36 3,000 4,785E-05 1,624E-03 ! cell cycle checkpoint GO:0000075 145 71 4,000 4,927E-05 1,649E-03 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 3,000 5,342E-05 1,764E-03 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! odontogenesis GO:0042476 74 37 3,000 5,342E-05 1,74E-03 ! RNA polyadenylation GO:0043631 32 14 2,000 5,923E-05 1,904E-03 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 2,000 5,923E-05 1,879E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 5,923E-05 1,855E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 3,000 5,945E-05 1,838E-03 ! regulation of transcription factor activity GO:0051090 137 75 4,000 6,415E-05 1,959E-03 GO:0090046|regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 71 39 3,000 6,595E-05 1,989E-03 ! mitotic cell cycle checkpoint GO:0007093 76 39 3,000 6,595E-05 1,965E-03 ! mammary gland development GO:0030879 93 40 3,000 7,296E-05 2,148E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 7,374E-05 2,144E-03 ! actin cytoskeleton reorganization GO:0031532 38 15 2,000 7,374E-05 2,119E-03 ! positive regulation of oxidoreductase activity GO:0051353 22 15 2,000 7,374E-05 2,095E-03 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 8,859E-05 2,488E-03 ! dorsal/ventral pattern formation GO:0009953 75 42 3,000 8,859E-05 2,459E-03 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 2,000 9,038E-05 2,481E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 9,038E-05 2,453E-03 ! regulation of T-helper cell differentiation GO:0045622 30 16 2,000 9,038E-05 2,426E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 9,038E-05 2,4E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 9,038E-05 2,374E-03 ! negative regulation of cell cycle process GO:0010948 35 17 2,000 1,093E-04 2,841E-03 ! signal complex assembly GO:0007172 47 17 2,000 1,093E-04 2,811E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 1,093E-04 2,781E-03 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 2,000 1,093E-04 2,753E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 1,093E-04 2,725E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 1,093E-04 2,697E-03 ! RNA 3'-end processing GO:0031123 37 17 2,000 1,093E-04 2,67E-03 ! response to metal ion GO:0010038 158 84 4,000 1,102E-04 2,665E-03 ! T cell activation GO:0042110 189 84 4,000 1,102E-04 2,639E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 1,164E-04 2,761E-03 ! negative regulation of growth GO:0045926 168 85 4,000 1,165E-04 2,738E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 1,269E-04 2,953E-03 ! leukocyte migration GO:0050900 75 46 3,000 1,269E-04 2,925E-03 ! positive regulation of protein transport GO:0051222 80 46 3,000 1,269E-04 2,898E-03 ! regulation of protein transport GO:0051223 165 87 4,000 1,301E-04 2,943E-03 GO:0070201|regulation of establishment of protein localization, ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 2,000 1,306E-04 2,928E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 1,306E-04 2,901E-03 ! response to inorganic substance GO:0010035 173 90 4,000 1,527E-04 3,36E-03 ! proximal/distal pattern formation GO:0009954 33 19 2,000 1,545E-04 3,369E-03 ! embryonic organ morphogenesis GO:0048562 34 19 2,000 1,545E-04 3,34E-03 ! ossification GO:0001503 205 91 4,000 1,608E-04 3,447E-03 ! response to calcium ion GO:0051592 94 49 3,000 1,627E-04 3,456E-03 ! bone development GO:0060348 206 92 4,000 1,693E-04 3,566E-03 ! endocrine system development GO:0035270 109 50 3,000 1,76E-04 3,676E-03 ! activation of caspase activity GO:0006919 95 50 3,000 1,76E-04 3,645E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 1,781E-04 3,657E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 1,81E-04 3,685E-03 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 1,81E-04 3,654E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of myeloid cell differentiation GO:0045638 32 20 2,000 1,81E-04 3,624E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 1,81E-04 3,595E-03 ! regulation of defense response GO:0031347 171 95 4,000 1,968E-04 3,878E-03 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 2,000 2,103E-04 4,11E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 2,103E-04 4,077E-03 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 2,000 2,103E-04 4,045E-03 ! regulation of protein localization GO:0032880 188 97 4,000 2,17E-04 4,141E-03 ! epithelial tube morphogenesis GO:0060562 114 54 3,000 2,376E-04 4,499E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 2,425E-04 4,557E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 2,425E-04 4,522E-03 ! ureteric bud development GO:0001657 50 22 2,000 2,425E-04 4,488E-03 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 2,000 2,425E-04 4,454E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 2,425E-04 4,421E-03 ! response to glucocorticoid stimulus GO:0051384 42 22 2,000 2,425E-04 4,388E-03 ! gut development GO:0048565 44 22 2,000 2,425E-04 4,356E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 2,000 2,425E-04 4,324E-03 ! response to molecule of bacterial origin GO:0002237 40 23 2,000 2,777E-04 4,917E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 3,000 2,929E-04 5,148E-03 ! positive regulation of caspase activity GO:0043280 108 57 3,000 2,929E-04 5,111E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 3,000 2,929E-04 5,075E-03 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 1,000 3,054E-04 5,254E-03 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! regulation of collagen biosynthetic process GO:0032965 7 5 1,000 3,054E-04 5,217E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 3,054E-04 5,181E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 3,054E-04 5,145E-03 ! response to protozoan GO:0001562 13 5 1,000 3,054E-04 5,11E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 3,054E-04 5,075E-03 ! parathyroid gland development GO:0060017 14 5 1,000 3,054E-04 5,041E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 3,054E-04 5,007E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 3,054E-04 4,973E-03 ! neutrophil mediated immunity GO:0002446 7 5 1,000 3,054E-04 4,94E-03 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 1,000 3,054E-04 4,908E-03 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! valine metabolic process GO:0006573 12 5 1,000 3,054E-04 4,876E-03 ! positive regulation of filopodium assembly GO:0051491 16 5 1,000 3,054E-04 4,844E-03 GO:0051489|regulation of filopodium assembly, ! regulation of glycogen metabolic process GO:0070873 10 5 1,000 3,054E-04 4,813E-03 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 1,000 3,054E-04 4,782E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 3,054E-04 4,752E-03 ! response to mercury ion GO:0046689 8 5 1,000 3,054E-04 4,722E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 3,054E-04 4,692E-03 ! enteric nervous system development GO:0048484 8 5 1,000 3,054E-04 4,662E-03 ! receptor biosynthetic process GO:0032800 7 5 1,000 3,054E-04 4,634E-03 ! stem cell division GO:0017145 11 5 1,000 3,054E-04 4,605E-03 GO:0048103|somatic stem cell division, ! maintenance of location GO:0051235 124 58 3,000 3,132E-04 4,695E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 3,161E-04 4,709E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 3,161E-04 4,68E-03 ! response to corticosteroid stimulus GO:0031960 46 24 2,000 3,161E-04 4,652E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 3,161E-04 4,624E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 3,577E-04 5,202E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 3,577E-04 5,171E-03 ! receptor metabolic process GO:0043112 53 25 2,000 3,577E-04 5,141E-03 ! regulation of alpha-beta T cell activation GO:0046634 48 25 2,000 3,577E-04 5,111E-03 ! protein tetramerization GO:0051262 57 25 2,000 3,577E-04 5,081E-03 ! negative regulation of response to stimulus GO:0048585 106 61 3,000 3,803E-04 5,37E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 4,027E-04 5,655E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 2,000 4,027E-04 5,622E-03 ! negative regulation of cell development GO:0010721 83 26 2,000 4,027E-04 5,59E-03 GO:0050768|negative regulation of neurogenesis, ! odontogenesis of dentine-containing tooth GO:0042475 54 27 2,000 4,512E-04 6,228E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 4,512E-04 6,193E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 4,512E-04 6,158E-03 ! positive regulation of actin filament polymerization GO:0030838 11 6 1,000 4,564E-04 6,194E-03 ! forebrain regionalization GO:0021871 9 6 1,000 4,564E-04 6,16E-03 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 1,000 4,564E-04 6,126E-03 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 4,564E-04 6,092E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 1,000 4,564E-04 6,059E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 1,000 4,564E-04 6,026E-03 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 1,000 4,564E-04 5,994E-03 GO:0033135|regulation of peptidyl-serine phosphorylation, ! positive regulation of muscle hypertrophy GO:0014742 10 6 1,000 4,564E-04 5,962E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! paraxial mesoderm development GO:0048339 16 6 1,000 4,564E-04 5,93E-03 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 4,564E-04 5,899E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 4,564E-04 5,868E-03 ! regulation of collagen metabolic process GO:0010712 10 6 1,000 4,564E-04 5,837E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 4,564E-04 5,807E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,564E-04 5,777E-03 GO:0045686|negative regulation of glial cell differentiation, ! response to exogenous dsRNA GO:0043330 13 6 1,000 4,564E-04 5,747E-03 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 1,000 4,564E-04 5,717E-03 ! negative regulation of multicellular organism growth GO:0040015 9 6 1,000 4,564E-04 5,688E-03 ! neutrophil homeostasis GO:0001780 11 6 1,000 4,564E-04 5,659E-03 ! salivary gland morphogenesis GO:0007435 14 6 1,000 4,564E-04 5,631E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 4,564E-04 5,602E-03 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 1,000 4,564E-04 5,574E-03 ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 4,564E-04 5,547E-03 GO:0007439|ectodermal gut development, ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 1,000 4,564E-04 5,519E-03 ! organ or tissue specific immune response GO:0002251 8 6 1,000 4,564E-04 5,492E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 4,564E-04 5,465E-03 ! cellular anion homeostasis GO:0030002 11 6 1,000 4,564E-04 5,438E-03 GO:0055081|anion homeostasis, ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 4,571E-04 5,42E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 5,033E-04 5,94E-03 ! positive regulation of T cell differentiation GO:0045582 48 28 2,000 5,033E-04 5,911E-03 ! regulation of cytokine biosynthetic process GO:0042035 108 66 3,000 5,14E-04 6,008E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 5,442E-04 6,331E-03 ! extracellular matrix organization GO:0030198 146 68 3,000 5,758E-04 6,666E-03 ! positive regulation of T cell activation GO:0050870 124 68 3,000 5,758E-04 6,635E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 6,086E-04 6,98E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 6,086E-04 6,947E-03 ! lung development GO:0030324 165 69 3,000 6,086E-04 6,915E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 6,187E-04 6,997E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 2,000 6,187E-04 6,965E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 6,366E-04 7,134E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 6,366E-04 7,101E-03 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 1,000 6,366E-04 7,069E-03 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 6,366E-04 7,037E-03 ! neuron adhesion GO:0007158 14 7 1,000 6,366E-04 7,005E-03 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 6,366E-04 6,974E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 6,366E-04 6,942E-03 ! lipoprotein transport GO:0042953 14 7 1,000 6,366E-04 6,912E-03 ! spinal cord patterning GO:0021511 14 7 1,000 6,366E-04 6,881E-03 ! regulation of granule cell precursor proliferation GO:0021936 12 7 1,000 6,366E-04 6,851E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! male sex determination GO:0030238 15 7 1,000 6,366E-04 6,821E-03 ! spindle checkpoint GO:0031577 16 7 1,000 6,366E-04 6,791E-03 ! monocyte differentiation GO:0030224 16 7 1,000 6,366E-04 6,761E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 6,366E-04 6,732E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 6,366E-04 6,703E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 6,366E-04 6,674E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 6,366E-04 6,646E-03 ! axonal fasciculation GO:0007413 19 7 1,000 6,366E-04 6,618E-03 ! negative regulation of nuclear division GO:0051784 15 7 1,000 6,366E-04 6,589E-03 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 1,000 6,366E-04 6,562E-03 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 1,000 6,366E-04 6,534E-03 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 1,000 6,366E-04 6,507E-03 ! muscle adaptation GO:0043500 13 7 1,000 6,366E-04 6,48E-03 ! defense response to Gram-negative bacterium GO:0050829 10 7 1,000 6,366E-04 6,453E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 6,426E-04 6,488E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 6,822E-04 6,858E-03 ! respiratory tube development GO:0030323 171 72 3,000 7,149E-04 7,157E-03 ! actin filament organization GO:0007015 167 72 3,000 7,149E-04 7,128E-03 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 2,000 7,497E-04 7,445E-03 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 2,000 7,497E-04 7,415E-03 ! spindle organization GO:0007051 50 32 2,000 7,497E-04 7,385E-03 ! positive regulation of T cell proliferation GO:0042102 60 32 2,000 7,497E-04 7,355E-03 ! metanephros development GO:0001656 81 32 2,000 7,497E-04 7,326E-03 ! peripheral nervous system development GO:0007422 68 32 2,000 7,497E-04 7,296E-03 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 2,000 7,497E-04 7,267E-03 ! regulation of caspase activity GO:0043281 136 74 3,000 7,926E-04 7,654E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 7,926E-04 7,624E-03 ! respiratory system development GO:0060541 175 74 3,000 7,926E-04 7,594E-03 ! negative regulation of protein transport GO:0051224 74 33 2,000 8,212E-04 7,837E-03 ! phosphoinositide-mediated signaling GO:0048015 141 75 3,000 8,337E-04 7,925E-03 ! axon guidance GO:0007411 162 75 3,000 8,337E-04 7,894E-03 ! succinate metabolic process GO:0006105 17 8 1,000 8,456E-04 7,976E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 8,456E-04 7,946E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 8,456E-04 7,915E-03 ! L-phenylalanine metabolic process GO:0006558 12 8 1,000 8,456E-04 7,885E-03 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 1,000 8,456E-04 7,855E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 8,456E-04 7,825E-03 ! regulation of muscle hypertrophy GO:0014743 12 8 1,000 8,456E-04 7,796E-03 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 8,456E-04 7,766E-03 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 8,456E-04 7,737E-03 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 1,000 8,456E-04 7,709E-03 ! negative regulation of translational initiation GO:0045947 12 8 1,000 8,456E-04 7,68E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 8,456E-04 7,651E-03 ! response to tumor cell GO:0002347 16 8 1,000 8,456E-04 7,623E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 8,456E-04 7,595E-03 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 8,456E-04 7,567E-03 GO:0002688|regulation of leukocyte chemotaxis, ! myeloid cell homeostasis GO:0002262 15 8 1,000 8,456E-04 7,54E-03 ! regulation of blood pressure GO:0008217 134 76 3,000 8,762E-04 7,784E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 8,97E-04 7,94E-03 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 9,202E-04 8,116E-03 ! positive regulation of lymphocyte activation GO:0051251 142 78 3,000 9,658E-04 8,487E-03 ! telencephalon development GO:0021537 81 35 2,000 9,771E-04 8,556E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 3,000 1,013E-03 8,837E-03 ! protein oligomerization GO:0051259 149 79 3,000 1,013E-03 8,806E-03 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 2,000 1,062E-03 9,197E-03 ! embryonic organ development GO:0048568 67 36 2,000 1,062E-03 9,164E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,083E-03 9,318E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 1,083E-03 9,286E-03 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 1,083E-03 9,253E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,083E-03 9,221E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,083E-03 9,189E-03 ! receptor clustering GO:0043113 20 9 1,000 1,083E-03 9,157E-03 ! regulation of Notch signaling pathway GO:0008593 24 9 1,000 1,083E-03 9,126E-03 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 1,000 1,083E-03 9,094E-03 ! cerebellum morphogenesis GO:0021587 14 9 1,000 1,083E-03 9,063E-03 GO:0021696|cerebellar cortex morphogenesis, ! regulation of T-helper 1 type immune response GO:0002825 12 9 1,000 1,083E-03 9,032E-03 ! S phase GO:0051320 10 9 1,000 1,083E-03 9,001E-03 GO:0000084|S phase of mitotic cell cycle, ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,083E-03 8,971E-03 ! regulation of muscle adaptation GO:0043502 14 9 1,000 1,083E-03 8,941E-03 ! tissue remodeling GO:0048771 78 37 2,000 1,151E-03 9,464E-03 ! maintenance of protein location in cell GO:0032507 89 37 2,000 1,151E-03 9,432E-03 ! negative regulation of cell activation GO:0050866 69 37 2,000 1,151E-03 9,401E-03 ! regulation of peptidase activity GO:0052547 150 82 3,000 1,164E-03 9,478E-03 ! regulation of adenylate cyclase activity GO:0045761 165 83 3,000 1,218E-03 9,882E-03 ! exocytosis GO:0006887 153 83 3,000 1,218E-03 9,849E-03 ! meiosis I GO:0007127 74 38 2,000 1,244E-03 0,01003086 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 2,000 1,244E-03 9,998E-03 ! regulation of protein stability GO:0031647 77 38 2,000 1,244E-03 9,965E-03 ! regulation of ligase activity GO:0051340 147 84 3,000 1,273E-03 0,01016278 ! regulation of cyclase activity GO:0031279 168 85 3,000 1,33E-03 0,01058411 ! carbohydrate homeostasis GO:0033500 59 39 2,000 1,342E-03 0,01064677 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 2,000 1,342E-03 0,01061231 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 1,000 1,349E-03 0,01063184 ! regulation of developmental growth GO:0048638 16 10 1,000 1,349E-03 0,01059765 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 1,349E-03 0,01056369 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 1,000 1,349E-03 0,01052994 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 1,000 1,349E-03 0,0104964 ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 1,349E-03 0,01046308 ! positive regulation of survival gene product expression GO:0045885 26 10 1,000 1,349E-03 0,01042997 ! myeloid leukocyte mediated immunity GO:0002444 14 10 1,000 1,349E-03 0,01039707 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,349E-03 0,01036437 GO:0006600|creatine metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,349E-03 0,01033188 ! motor axon guidance GO:0008045 22 10 1,000 1,349E-03 0,0102996 ! protein heterooligomerization GO:0051291 17 10 1,000 1,349E-03 0,01026751 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,349E-03 0,01023562 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,349E-03 0,01020393 ! response to dsRNA GO:0043331 23 10 1,000 1,349E-03 0,01017244 ! positive regulation of interleukin-6 production GO:0032755 14 10 1,000 1,349E-03 0,01014114 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 1,349E-03 0,01011003 ! synaptic vesicle endocytosis GO:0048488 23 10 1,000 1,349E-03 0,01007911 ! hindbrain morphogenesis GO:0021575 19 10 1,000 1,349E-03 0,01004839 ! salivary gland development GO:0007431 28 10 1,000 1,349E-03 0,01001784 ! positive regulation of acute inflammatory response GO:0002675 18 10 1,000 1,349E-03 9,987E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,349E-03 9,957E-03 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 1,000 1,349E-03 9,927E-03 ! cerebellar cortex development GO:0021695 16 10 1,000 1,349E-03 9,898E-03 ! regulation of cAMP biosynthetic process GO:0030817 173 86 3,000 1,389E-03 0,01015912 ! regulation of lyase activity GO:0051339 169 86 3,000 1,389E-03 0,01012879 ! positive regulation of cell activation GO:0050867 161 86 3,000 1,389E-03 0,01009865 GO:0002696|positive regulation of leukocyte activation, ! nucleus organization GO:0006997 73 40 2,000 1,445E-03 0,01047666 ! mitochondrion organization GO:0007005 159 87 3,000 1,45E-03 0,01047737 ! maintenance of protein location GO:0045185 95 41 2,000 1,553E-03 0,01119127 ! embryonic epithelial tube formation GO:0001838 85 41 2,000 1,553E-03 0,01115836 ! regulation of cAMP metabolic process GO:0030814 182 89 3,000 1,576E-03 0,01129382 ! tube morphogenesis GO:0035239 194 89 3,000 1,576E-03 0,0112608 ! regulation of cell cycle process GO:0010564 161 90 3,000 1,643E-03 0,01169962 ! neuron fate specification GO:0048665 18 11 1,000 1,643E-03 0,01166724 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,643E-03 0,01163342 ! keratinocyte proliferation GO:0043616 19 11 1,000 1,643E-03 0,01159979 ! blood vessel remodeling GO:0001974 30 11 1,000 1,643E-03 0,01156637 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,643E-03 0,01153313 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of intracellular pH GO:0051453 21 11 1,000 1,643E-03 0,01150008 ! negative regulation of ossification GO:0030279 27 11 1,000 1,643E-03 0,01146723 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 1,643E-03 0,01143456 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,643E-03 0,01140207 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 1,000 1,643E-03 0,01136977 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,643E-03 0,01133765 ! nitric oxide mediated signal transduction GO:0007263 26 11 1,000 1,643E-03 0,01130572 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 1,000 1,643E-03 0,01127396 ! thymus development GO:0048538 29 11 1,000 1,643E-03 0,01124238 ! embryonic gut development GO:0048566 19 11 1,000 1,643E-03 0,01121097 ! regulation of embryonic development GO:0045995 35 11 1,000 1,643E-03 0,01117975 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 2,000 1,666E-03 0,01130286 ! T cell differentiation GO:0030217 93 42 2,000 1,666E-03 0,01127155 ! cytokinesis GO:0000910 84 42 2,000 1,666E-03 0,01124041 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 3,000 1,711E-03 0,01151352 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of transcription factor activity GO:0051091 71 43 2,000 1,783E-03 0,0119681 GO:0090047|positive regulation of transcription regulator activity, ! neuron migration GO:0001764 85 43 2,000 1,783E-03 0,01193531 ! regulation of myeloid cell differentiation GO:0045637 105 43 2,000 1,783E-03 0,0119027 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,964E-03 0,0130752 ! virus-host interaction GO:0019048 30 12 1,000 1,964E-03 0,01303967 ! regulation of B cell proliferation GO:0030888 22 12 1,000 1,964E-03 0,01300433 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 1,964E-03 0,01296919 ! regulation of cell projection assembly GO:0060491 33 12 1,000 1,964E-03 0,01293423 ! hippocampus development GO:0021766 29 12 1,000 1,964E-03 0,01289946 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,964E-03 0,01286488 ! ventral spinal cord development GO:0021517 25 12 1,000 1,964E-03 0,01283048 ! tyrosine metabolic process GO:0006570 19 12 1,000 1,964E-03 0,01279626 ! focal adhesion formation GO:0048041 37 12 1,000 1,964E-03 0,01276223 ! regulation of interleukin-12 production GO:0032655 19 12 1,000 1,964E-03 0,01272838 ! cranial nerve development GO:0021545 23 12 1,000 1,964E-03 0,01269471 ! regulation of leukocyte migration GO:0002685 29 12 1,000 1,964E-03 0,01266121 ! defense response to Gram-positive bacterium GO:0050830 14 12 1,000 1,964E-03 0,01262789 ! lamellipodium assembly GO:0030032 24 12 1,000 1,964E-03 0,01259475 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 3,000 2,003E-03 0,01280937 ! negative regulation of multicellular organismal process GO:0051241 174 95 3,000 2,003E-03 0,01277592 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 2,000 2,034E-03 0,01293848 ! maintenance of location in cell GO:0051651 101 45 2,000 2,034E-03 0,01290487 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 2,167E-03 0,0137134 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 2,167E-03 0,01367797 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 2,000 2,167E-03 0,01364272 ! pigmentation GO:0043473 103 46 2,000 2,167E-03 0,01360764 ! leukocyte differentiation GO:0002521 232 98 3,000 2,243E-03 0,01405346 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 2,243E-03 0,01401752 ! forebrain development GO:0030900 210 98 3,000 2,243E-03 0,01398176 ! regulation of nucleotide metabolic process GO:0006140 197 98 3,000 2,243E-03 0,01394618 ! neural tube development GO:0021915 91 47 2,000 2,305E-03 0,01429258 ! regulation of chemokine production GO:0032642 18 13 1,000 2,313E-03 0,01430459 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 2,313E-03 0,01426847 ! endocrine pancreas development GO:0031018 25 13 1,000 2,313E-03 0,01423253 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 1,000 2,313E-03 0,01419677 ! response to X-ray GO:0010165 28 13 1,000 2,313E-03 0,01416119 ! exocrine system development GO:0035272 34 13 1,000 2,313E-03 0,01412579 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,313E-03 0,01409056 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! nucleoside triphosphate catabolic process GO:0009143 22 13 1,000 2,313E-03 0,01405551 ! gland morphogenesis GO:0022612 31 13 1,000 2,313E-03 0,01402063 ! regulation of acute inflammatory response GO:0002673 24 13 1,000 2,313E-03 0,01398593 ! aromatic amino acid family catabolic process GO:0009074 20 13 1,000 2,313E-03 0,01395139 ! spleen development GO:0048536 24 13 1,000 2,313E-03 0,01391703 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,313E-03 0,01388284 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of JAK-STAT cascade GO:0046425 76 48 2,000 2,449E-03 0,0146624 ! cellular component disassembly GO:0022411 89 48 2,000 2,449E-03 0,01462655 ! positive regulation of DNA binding GO:0043388 83 48 2,000 2,449E-03 0,01459088 ! regulation of adaptive immune response GO:0002819 92 48 2,000 2,449E-03 0,01455538 ! detection of stimulus involved in sensory perception GO:0050906 75 49 2,000 2,598E-03 0,0154041 ! lipid localization GO:0010876 32 14 1,000 2,688E-03 0,01590294 GO:0019915|lipid storage, ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 2,688E-03 0,01586453 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 2,688E-03 0,0158263 ! regulation of cellular pH GO:0030641 27 14 1,000 2,688E-03 0,01578826 ! cerebellum development GO:0021549 23 14 1,000 2,688E-03 0,0157504 ! regulation of T-helper 2 type immune response GO:0002828 25 14 1,000 2,688E-03 0,01571272 ! response to gamma radiation GO:0010332 30 14 1,000 2,688E-03 0,01567522 ! male genitalia development GO:0030539 26 14 1,000 2,688E-03 0,0156379 ! positive regulation of protein polymerization GO:0032273 27 14 1,000 2,688E-03 0,01560075 ! regulation of ossification GO:0030278 123 50 2,000 2,752E-03 0,01593397 ! positive regulation of cytokine production GO:0001819 94 50 2,000 2,752E-03 0,0158963 ! detection of abiotic stimulus GO:0009582 80 51 2,000 2,913E-03 0,01678149 ! negative regulation of immune system process GO:0002683 101 51 2,000 2,913E-03 0,01674201 ! positive regulation of binding GO:0051099 88 52 2,000 3,078E-03 0,01765329 ! morphogenesis of embryonic epithelium GO:0016331 106 52 2,000 3,078E-03 0,01761195 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,091E-03 0,01764171 ! sulfate transport GO:0008272 27 15 1,000 3,091E-03 0,01760059 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 1,000 3,091E-03 0,01755965 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 3,091E-03 0,01751891 ! regulation of exocytosis GO:0017157 26 15 1,000 3,091E-03 0,01747836 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3,091E-03 0,01743799 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 1,000 3,091E-03 0,01739781 ! positive regulation of growth GO:0045927 96 53 2,000 3,25E-03 0,01825089 ! chromatin remodeling GO:0006338 122 53 2,000 3,25E-03 0,01820903 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 3,25E-03 0,01816736 ! cartilage development GO:0051216 99 53 2,000 3,25E-03 0,01812588 ! regulation of angiogenesis GO:0045765 125 54 2,000 3,427E-03 0,01907062 ! regulation of muscle contraction GO:0006937 94 54 2,000 3,427E-03 0,01902728 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 2,000 3,427E-03 0,01898413 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,519E-03 0,01945198 ! bone remodeling GO:0046849 28 16 1,000 3,519E-03 0,01940807 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 3,519E-03 0,01936435 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 3,519E-03 0,01932084 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 1,000 3,519E-03 0,01927752 ! pituitary gland development GO:0021983 30 16 1,000 3,519E-03 0,01923439 ! neuron recognition GO:0008038 40 16 1,000 3,519E-03 0,01919146 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,519E-03 0,01914872 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 3,61E-03 0,01959788 ! cell maturation GO:0048469 107 55 2,000 3,61E-03 0,01955443 ! metencephalon development GO:0022037 32 17 1,000 3,974E-03 0,02147908 ! negative regulation of hormone secretion GO:0046888 26 17 1,000 3,974E-03 0,02143166 ! endothelial cell migration GO:0043542 31 17 1,000 3,974E-03 0,02138445 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 3,974E-03 0,02133745 ! genitalia development GO:0048806 32 17 1,000 3,974E-03 0,02129066 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 3,974E-03 0,02124407 ! regulation of bone remodeling GO:0046850 143 57 2,000 3,994E-03 0,02130183 ! aging GO:0007568 112 58 2,000 4,194E-03 0,02232387 ! regulation of tissue remodeling GO:0034103 146 58 2,000 4,194E-03 0,02227534 ! positive regulation of organelle organization GO:0010638 108 58 2,000 4,194E-03 0,02222702 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 4,454E-03 0,02355459 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 4,454E-03 0,02350372 ! limbic system development GO:0021761 40 18 1,000 4,454E-03 0,02345307 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 4,454E-03 0,02340263 GO:0050886|endocrine process, ! epidermis morphogenesis GO:0048730 43 18 1,000 4,454E-03 0,02335241 ! cell-substrate junction assembly GO:0007044 56 18 1,000 4,454E-03 0,0233024 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 4,454E-03 0,02325261 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 4,454E-03 0,02320303 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 1,000 4,454E-03 0,02315366 ! neural crest cell migration GO:0001755 41 18 1,000 4,454E-03 0,02310451 ! long-chain fatty acid transport GO:0015909 32 18 1,000 4,454E-03 0,02305556 ! regulation of immunoglobulin production GO:0002637 49 18 1,000 4,454E-03 0,02300681 ! nerve development GO:0021675 34 18 1,000 4,454E-03 0,02295827 ! defense response to virus GO:0051607 43 18 1,000 4,454E-03 0,02290994 ! DNA catabolic process GO:0006308 94 60 2,000 4,614E-03 0,02368023 ! regulation of heart contraction GO:0008016 123 61 2,000 4,833E-03 0,02475211 ! positive regulation of translation GO:0045727 31 19 1,000 4,96E-03 0,02535165 ! neuron maturation GO:0042551 46 19 1,000 4,96E-03 0,02529872 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 4,96E-03 0,02524601 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 4,96E-03 0,02519353 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 4,96E-03 0,02514126 ! pigmentation during development GO:0048066 42 19 1,000 4,96E-03 0,02508921 ! neuromuscular junction development GO:0007528 43 19 1,000 4,96E-03 0,02503737 ! response to lipopolysaccharide GO:0032496 34 19 1,000 4,96E-03 0,02498575 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 4,96E-03 0,02493433 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 1,000 4,96E-03 0,02488313 ! peptide hormone secretion GO:0030072 32 19 1,000 4,96E-03 0,02483214 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 5,058E-03 0,02526957 ! regulation of homeostatic process GO:0032844 148 62 2,000 5,058E-03 0,025218 ! regulation of mitosis GO:0007088 112 63 2,000 5,289E-03 0,02631791 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 2,000 5,289E-03 0,02626441 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 5,491E-03 0,02721179 ! skin development GO:0043588 42 20 1,000 5,491E-03 0,02715671 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 1,000 5,491E-03 0,02710184 ! response to alkaloid GO:0043279 38 20 1,000 5,491E-03 0,0270472 ! pancreas development GO:0031016 40 20 1,000 5,491E-03 0,02699278 ! actin filament bundle formation GO:0051017 47 20 1,000 5,491E-03 0,02693858 ! peptide secretion GO:0002790 38 20 1,000 5,491E-03 0,02688459 ! regulation of interleukin-2 production GO:0032663 39 20 1,000 5,491E-03 0,02683083 ! aromatic compound catabolic process GO:0019439 31 20 1,000 5,491E-03 0,02677727 ! negative regulation of translation GO:0017148 32 20 1,000 5,491E-03 0,02672393 ! hormone secretion GO:0046879 39 21 1,000 6,047E-03 0,02937074 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 6,047E-03 0,02931247 ! regulation of vasoconstriction GO:0019229 40 21 1,000 6,047E-03 0,02925442 ! diencephalon development GO:0021536 36 21 1,000 6,047E-03 0,02919661 ! collagen fibril organization GO:0030199 62 21 1,000 6,047E-03 0,02913902 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 6,047E-03 0,02908166 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 6,047E-03 0,02902453 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 6,047E-03 0,02896762 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 6,047E-03 0,02891093 ! activation of MAPK activity GO:0000187 124 67 2,000 6,278E-03 0,02995609 ! embryonic limb morphogenesis GO:0030326 139 67 2,000 6,278E-03 0,0298977 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 126 67 2,000 6,278E-03 0,02983953 ! negative regulation of ligase activity GO:0051352 116 68 2,000 6,541E-03 0,03103007 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 2,000 6,541E-03 0,03096993 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 2,000 6,541E-03 0,03091003 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 1,000 6,628E-03 0,0312579 ! glutamate signaling pathway GO:0007215 48 22 1,000 6,628E-03 0,03119767 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 6,628E-03 0,03113768 ! cellular response to starvation GO:0009267 37 22 1,000 6,628E-03 0,03107791 ! cell aging GO:0007569 48 22 1,000 6,628E-03 0,03101837 ! renal system process GO:0003014 42 22 1,000 6,628E-03 0,03095907 ! detection of chemical stimulus GO:0009593 42 22 1,000 6,628E-03 0,03089998 ! positive regulation of B cell activation GO:0050871 42 22 1,000 6,628E-03 0,03084113 ! protein stabilization GO:0050821 41 22 1,000 6,628E-03 0,03078249 ! developmental maturation GO:0021700 128 69 2,000 6,811E-03 0,03157361 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 7,233E-03 0,03346407 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 7,233E-03 0,03340081 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 7,233E-03 0,03333779 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 7,233E-03 0,03327501 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 7,233E-03 0,03321246 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 7,233E-03 0,03315015 ! regulation of interleukin-6 production GO:0032675 31 23 1,000 7,233E-03 0,03308807 ! fatty acid transport GO:0015908 47 23 1,000 7,233E-03 0,03302623 ! regulation of bone mineralization GO:0030500 54 23 1,000 7,233E-03 0,03296461 ! hormone transport GO:0009914 41 23 1,000 7,233E-03 0,03290322 ! appendage morphogenesis GO:0035107 150 72 2,000 7,659E-03 0,03478011 GO:0035108|limb morphogenesis, ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 2,000 7,659E-03 0,03471558 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 7,861E-03 0,03556501 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 7,861E-03 0,03549927 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 7,861E-03 0,03543377 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 7,861E-03 0,03536851 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 7,861E-03 0,0353035 ! sex determination GO:0007530 48 24 1,000 7,861E-03 0,03523872 ! pallium development GO:0021543 56 24 1,000 7,861E-03 0,03517418 ! synaptic vesicle transport GO:0048489 52 24 1,000 7,861E-03 0,03510988 ! platelet activation GO:0030168 41 24 1,000 7,861E-03 0,03504581 ! aromatic amino acid family metabolic process GO:0009072 37 24 1,000 7,861E-03 0,03498197 ! negative regulation of catabolic process GO:0009895 52 24 1,000 7,861E-03 0,03491837 ! appendage development GO:0048736 151 73 2,000 7,955E-03 0,03527184 GO:0060173|limb development, ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 8,514E-03 0,03767956 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 8,514E-03 0,03761142 ! phototransduction GO:0007602 37 25 1,000 8,514E-03 0,03754353 ! negative regulation of DNA replication GO:0008156 45 25 1,000 8,514E-03 0,03747589 ! interaction with host GO:0051701 66 25 1,000 8,514E-03 0,03740848 ! regulation of biomineral formation GO:0070167 56 25 1,000 8,514E-03 0,03734132 ! positive regulation of protein secretion GO:0050714 41 25 1,000 8,514E-03 0,0372744 ! leukocyte homeostasis GO:0001776 50 25 1,000 8,514E-03 0,03720772 ! lymphocyte differentiation GO:0030098 193 76 2,000 8,883E-03 0,03875366 ! myelination GO:0042552 50 26 1,000 9,19E-03 0,04001851 ! spinal cord development GO:0021510 54 26 1,000 9,19E-03 0,0399473 ! vesicle docking during exocytosis GO:0006904 49 26 1,000 9,19E-03 0,03987635 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 9,19E-03 0,03980565 ! neural crest cell development GO:0014032 59 26 1,000 9,19E-03 0,0397352 GO:0014033|neural crest cell differentiation, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 9,19E-03 0,03966499 ! positive regulation of nuclear division GO:0051785 41 26 1,000 9,19E-03 0,03959504 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 9,19E-03 0,03952533 ! regulation of catabolic process GO:0009894 173 77 2,000 9,206E-03 0,03952675 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 9,872E-03 0,04231207 ! positive regulation of cell projection organization GO:0031346 66 27 1,000 9,889E-03 0,04230863 ! mitochondrial membrane organization GO:0007006 60 27 1,000 9,889E-03 0,04223466 ! response to starvation GO:0042594 47 27 1,000 9,889E-03 0,04216096 ! cellular response to nutrient levels GO:0031669 45 27 1,000 9,889E-03 0,0420875 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01021551 0,04340259 ! meiosis GO:0007126 143 81 2,000 0,01056565 0,04481229 GO:0051327|M phase of meiotic cell cycle, ! neuron fate commitment GO:0048663 52 28 1,000 0,01061071 0,04492542 ! vesicle docking GO:0048278 55 28 1,000 0,01061071 0,0448477 ! fat cell differentiation GO:0045444 57 28 1,000 0,01061071 0,04477024 ! base-excision repair GO:0006284 41 28 1,000 0,01061071 0,04469305 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 0,01061071 0,04461613 ! meiotic cell cycle GO:0051321 144 82 2,000 0,01092268 0,04584896 ! inorganic anion transport GO:0015698 156 83 2,000 0,01128662 0,04729538 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01135528 0,04750161 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01135528 0,04742041 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01135528 0,04733949 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 0,01135528 0,04725884 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01135528 0,04717847 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01135528 0,04709837 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,01203533 0,04983441 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 1,000 0,01212218 0,0501091 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! acute-phase response GO:0006953 50 30 1,000 0,01212218 0,05002446 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01212218 0,0499401 ! neurotransmitter secretion GO:0007269 55 30 1,000 0,01212218 0,04985602 ! cell junction assembly GO:0034329 85 31 1,000 0,01291114 0,05301164 ! peptide transport GO:0015833 60 31 1,000 0,01291114 0,05292269 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01291114 0,05283404 ! detection of light stimulus GO:0009583 44 31 1,000 0,01291114 0,05274569 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,01291114 0,05265763 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01291114 0,05256987 GO:0008366|axon ensheathment, ! eye morphogenesis GO:0048592 65 31 1,000 0,01291114 0,0524824 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01372191 0,05568542 ! mesoderm formation GO:0001707 73 32 1,000 0,01372191 0,05559308 ! hindbrain development GO:0030902 65 32 1,000 0,01372191 0,05550103 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01372191 0,0554093 ! regulation of pH GO:0006885 56 33 1,000 0,01455421 0,05867316 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,01455421 0,0585765 ! response to ionizing radiation GO:0010212 74 33 1,000 0,01455421 0,05848016 ! regulation of cell adhesion GO:0030155 241 92 2,000 0,01487649 0,05967697 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 0,01531061 0,06131776 GO:0010498|proteasomal protein catabolic process, ! formation of primary germ layer GO:0001704 76 34 1,000 0,01540778 0,06160591 ! cell fate specification GO:0001708 56 34 1,000 0,01540778 0,06150525 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01540778 0,06140492 ! DNA damage checkpoint GO:0000077 78 35 1,000 0,01628237 0,06478473 ! negative regulation of secretion GO:0051048 68 35 1,000 0,01628237 0,06467939 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01628237 0,06457439 ! membrane docking GO:0022406 69 35 1,000 0,01628237 0,06446973 ! mesoderm morphogenesis GO:0048332 80 35 1,000 0,01628237 0,06436541 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01628237 0,06426143 ! placenta development GO:0001890 53 35 1,000 0,01628237 0,06415778 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01717771 0,0675767 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01717771 0,06746806 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01809354 0,07095108 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01809354 0,07083737 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01809354 0,07072403 ! actomyosin structure organization GO:0031032 68 37 1,000 0,01809354 0,07061105 ! cell junction organization GO:0034330 96 37 1,000 0,01809354 0,07049844 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,01902962 0,07402765 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,01902962 0,07390996 ! neural tube formation GO:0001841 79 38 1,000 0,01902962 0,07379264 ! nucleotide catabolic process GO:0009166 70 39 1,000 0,01998569 0,07737725 ! learning GO:0007612 82 40 1,000 0,02096151 0,08102684 ! lipid homeostasis GO:0055088 75 40 1,000 0,02096151 0,08089884 ! mismatch repair GO:0006298 58 40 1,000 0,02096151 0,08077124 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02096151 0,08064404 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,02096151 0,08051724 ! regulation of hormone secretion GO:0046883 69 41 1,000 0,02195682 0,08420802 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 1,000 0,02195682 0,08407603 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,02195682 0,08394446 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,02195682 0,08381329 ! mesenchymal cell development GO:0014031 94 41 1,000 0,02195682 0,08368254 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,02195682 0,08355219 ! ear morphogenesis GO:0042471 64 42 1,000 0,02297138 0,08727696 ! regulation of protein secretion GO:0050708 77 42 1,000 0,02297138 0,08714143 ! epithelial cell differentiation GO:0030855 83 43 1,000 0,02400495 0,09092107 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 1,000 0,02400495 0,09078033 ! regulation of tube size GO:0035150 76 43 1,000 0,02400495 0,09064002 GO:0050880|regulation of blood vessel size, ! glucose transport GO:0015758 66 43 1,000 0,02400495 0,09050014 ! monocarboxylic acid transport GO:0015718 93 43 1,000 0,02400495 0,0903607 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,02400495 0,09022168 ! hexose transport GO:0008645 68 44 1,000 0,02505729 0,09403218 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,02505729 0,09388796 ! double-strand break repair GO:0006302 85 44 1,000 0,02505729 0,09374418 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,02612815 0,09760102 ! B cell differentiation GO:0030183 124 45 1,000 0,02612815 0,09745201 ! developmental growth GO:0048589 88 45 1,000 0,02612815 0,09730346 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,0272173 0,10120528 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02754575 0,10227091 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02754575 0,10211572 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02754575 0,101961 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02754575 0,10180675 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02754575 0,10165296 ! neuron fate determination GO:0048664 7 5 0,000 0,02754575 0,10149964 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02754575 0,10134678 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02754575 0,10119438 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02754575 0,10104243 ! polyol transport GO:0015791 12 5 0,000 0,02754575 0,10089095 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02754575 0,10073991 ! response to superoxide GO:0000303 10 5 0,000 0,02754575 0,10058933 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02754575 0,10043919 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02754575 0,10028951 GO:0045940|positive regulation of steroid metabolic process, ! tongue development GO:0043586 8 5 0,000 0,02754575 0,10014027 ! female meiosis GO:0007143 10 5 0,000 0,02754575 0,09999147 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02754575 0,09984312 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02754575 0,0996952 ! hypothalamus development GO:0021854 9 5 0,000 0,02754575 0,09954772 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02754575 0,09940068 ! cobalt ion transport GO:0006824 11 5 0,000 0,02754575 0,09925407 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02754575 0,09910789 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02754575 0,09896215 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02754575 0,09881683 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02754575 0,09867194 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02754575 0,09852747 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02754575 0,09838342 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02754575 0,0982398 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02754575 0,09809659 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! transposition GO:0032196 9 5 0,000 0,02754575 0,0979538 ! negative chemotaxis GO:0050919 16 5 0,000 0,02754575 0,09781143 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02754575 0,09766946 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02754575 0,09752791 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02754575 0,09738677 ! behavioral response to pain GO:0048266 10 5 0,000 0,02754575 0,09724604 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02754575 0,09710572 ! Notch receptor processing GO:0007220 11 5 0,000 0,02754575 0,09696579 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02754575 0,09682627 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02754575 0,09668716 ! micturition GO:0060073 9 5 0,000 0,02754575 0,09654844 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02754575 0,09641012 ! copulation GO:0007620 9 5 0,000 0,02754575 0,09627219 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02754575 0,09613466 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02754575 0,09599752 ! bioluminescence GO:0008218 9 5 0,000 0,02754575 0,09586077 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02754575 0,09572441 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02754575 0,09558844 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02754575 0,09545285 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02754575 0,09531765 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02754575 0,09518283 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02754575 0,09504839 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02754575 0,09491433 ! grooming behavior GO:0007625 6 5 0,000 0,02754575 0,09478065 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02754575 0,09464734 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02754575 0,09451441 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02754575 0,09438185 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02754575 0,09424966 ! lymph vessel development GO:0001945 10 5 0,000 0,02754575 0,09411785 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02754575 0,0939864 ! endochondral ossification GO:0001958 17 5 0,000 0,02754575 0,09385531 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02754575 0,0937246 ! single strand break repair GO:0000012 8 5 0,000 0,02754575 0,09359424 ! anagen GO:0042640 7 5 0,000 0,02754575 0,09346425 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02754575 0,09333462 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02754575 0,09320535 ! cytokine secretion GO:0050663 15 5 0,000 0,02754575 0,09307643 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02754575 0,09294787 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02754575 0,09281967 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02754575 0,09269182 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02754575 0,09256432 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02754575 0,09243717 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02754575 0,09231037 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02754575 0,09218392 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02754575 0,09205781 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02754575 0,09193205 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02754575 0,09180663 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02754575 0,09168155 ! microvillus organization GO:0032528 8 5 0,000 0,02754575 0,09155682 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02754575 0,09143242 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02754575 0,09130836 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02754575 0,09118463 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02754575 0,09106125 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02754575 0,09093819 ! polyol catabolic process GO:0046174 9 5 0,000 0,02754575 0,09081547 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02754575 0,09069307 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02754575 0,09057101 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02754575 0,09044927 ! muscle cell migration GO:0014812 8 5 0,000 0,02754575 0,09032787 ! mitochondrial fission GO:0000266 8 5 0,000 0,02754575 0,09020678 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02754575 0,09008602 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02754575 0,08996559 ! mRNA transcription GO:0009299 10 5 0,000 0,02754575 0,08984547 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02754575 0,08972568 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02754575 0,08960621 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02754575 0,08948705 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02754575 0,08936821 ! monocyte activation GO:0042117 10 5 0,000 0,02754575 0,08924968 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02754575 0,08913147 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02754575 0,08901357 ! response to food GO:0032094 6 5 0,000 0,02754575 0,08889598 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02754575 0,08877871 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02754575 0,08866174 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02754575 0,08854508 ! forebrain neuron development GO:0021884 13 5 0,000 0,02754575 0,08842873 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02754575 0,08831268 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02754575 0,08819693 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02754575 0,08808149 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02754575 0,08796635 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02754575 0,08785152 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02754575 0,08773698 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02754575 0,08762274 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02754575 0,08750879 ! lipid glycosylation GO:0030259 7 5 0,000 0,02754575 0,08739514 ! nucleobase transport GO:0015851 6 5 0,000 0,02754575 0,08728179 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02754575 0,08716873 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02754575 0,08705596 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02754575 0,08694349 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02754575 0,0868313 ! basic amino acid transport GO:0015802 12 5 0,000 0,02754575 0,08671941 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02754575 0,0866078 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02754575 0,08649648 ! actin nucleation GO:0045010 11 5 0,000 0,02754575 0,08638544 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02754575 0,08627469 ! depurination GO:0045007 5 5 0,000 0,02754575 0,08616423 ! depyrimidination GO:0045008 10 5 0,000 0,02754575 0,08605404 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02754575 0,08594414 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02754575 0,08583452 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02754575 0,08572517 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02754575 0,08561611 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02754575 0,08550732 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02754575 0,08539881 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02754575 0,08529057 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02754575 0,08518261 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02754575 0,08507492 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02754575 0,0849675 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02754575 0,08486035 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02754575 0,08475348 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02754575 0,08464687 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02754575 0,08454053 ! response to arsenic GO:0046685 11 5 0,000 0,02754575 0,08443445 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02754575 0,08432865 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02754575 0,0842231 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02754575 0,08411783 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02754575 0,08401281 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02754575 0,08390806 ! response to cadmium ion GO:0046686 7 5 0,000 0,02754575 0,08380356 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02754575 0,08369933 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02754575 0,08359535 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02754575 0,08349164 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02754575 0,08338818 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02754575 0,08328498 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02754575 0,08318203 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02754575 0,08307933 ! decidualization GO:0046697 11 5 0,000 0,02754575 0,08297689 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02754575 0,08287471 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02754575 0,08277277 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02754575 0,08267108 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02754575 0,08256964 ! embryonic cleavage GO:0040016 6 5 0,000 0,02754575 0,08246846 ! peroxisome fission GO:0016559 5 5 0,000 0,02754575 0,08236752 ! histone demethylation GO:0016577 13 5 0,000 0,02754575 0,08226682 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02754575 0,08216637 ! mitotic recombination GO:0006312 9 5 0,000 0,02754575 0,08206617 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02754575 0,08196621 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02754575 0,0818665 ! metaphase plate congression GO:0051310 7 5 0,000 0,02754575 0,08176702 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02754575 0,08166779 GO:0032374|regulation of cholesterol transport, ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02754575 0,0815688 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02754575 0,08147005 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02754575 0,08137154 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02754575 0,08127326 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02754575 0,08117522 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02754575 0,08107742 ! B cell homeostasis GO:0001782 13 5 0,000 0,02754575 0,08097986 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02754575 0,08088252 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02754575 0,08078543 ! metaphase GO:0051323 11 5 0,000 0,02754575 0,08068856 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02754575 0,08059193 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02754575 0,08049553 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02754575 0,08039936 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02754575 0,08030341 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02754575 0,0802077 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02754575 0,08011221 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02754575 0,08001696 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02754575 0,07992192 ! response to redox state GO:0051775 6 5 0,000 0,02754575 0,07982712 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02754575 0,07973254 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02754575 0,07963818 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02754575 0,07954404 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02754575 0,07945013 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02754575 0,07935644 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02754575 0,07926297 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02754575 0,07916972 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02754575 0,07907669 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02754575 0,07898387 ! striatum development GO:0021756 14 5 0,000 0,02754575 0,07889128 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02754575 0,0787989 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02754575 0,07870674 ! glial cell migration GO:0008347 10 5 0,000 0,02754575 0,07861479 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02754575 0,07852306 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02754575 0,07843154 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02754575 0,07834023 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02754575 0,07824914 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02754575 0,07815826 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02754575 0,07806759 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02754575 0,07797713 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02754575 0,07788688 ! neuroprotection GO:0043526 8 5 0,000 0,02754575 0,07779683 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02754575 0,077707 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02754575 0,07761737 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02754575 0,07752795 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02754575 0,07743873 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02754575 0,07734972 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02754575 0,07726092 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02754575 0,07717232 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02754575 0,07708392 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02754575 0,07699572 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02754575 0,07690773 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,02754575 0,07681993 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02754575 0,07673234 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02754575 0,07664494 ! spindle assembly GO:0051225 6 5 0,000 0,02754575 0,07655775 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02754575 0,07647075 GO:0022011|myelination in the peripheral nervous system, ! protein palmitoylation GO:0018345 12 5 0,000 0,02754575 0,07638395 ! drug metabolic process GO:0017144 7 5 0,000 0,02754575 0,07629735 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02754575 0,07621094 ! organ regeneration GO:0031100 7 5 0,000 0,02754575 0,07612473 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02754575 0,07603871 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02754575 0,07595289 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,02944955 0,08111076 ! mitochondrial transport GO:0006839 94 48 1,000 0,02944955 0,08101942 ! endosome transport GO:0016197 127 48 1,000 0,02944955 0,08092828 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,02944955 0,08083735 ! male sex differentiation GO:0046661 93 48 1,000 0,02944955 0,08074663 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,02944955 0,0806561 ! JNK cascade GO:0007254 106 49 1,000 0,03059217 0,08369169 ! protein homooligomerization GO:0051260 84 49 1,000 0,03059217 0,08359808 ! regulation of action potential GO:0001508 102 50 1,000 0,03175216 0,08667099 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,03175216 0,08657426 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,03292929 0,08968368 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,03292929 0,08958381 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03296362 0,08957746 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03296362 0,08947793 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03296362 0,08937862 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03296362 0,08927953 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03296362 0,08918066 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03296362 0,08908201 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03296362 0,08898357 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03296362 0,08888536 ! response to oxygen radical GO:0000305 11 6 0,000 0,03296362 0,08878736 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03296362 0,08868958 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03296362 0,08859201 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03296362 0,08849465 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03296362 0,08839751 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03296362 0,08830059 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03296362 0,08820387 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03296362 0,08810737 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03296362 0,08801108 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03296362 0,08791499 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03296362 0,08781912 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03296362 0,08772346 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03296362 0,087628 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03296362 0,08753276 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03296362 0,08743771 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03296362 0,08734288 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03296362 0,08724825 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03296362 0,08715383 ! malate metabolic process GO:0006108 13 6 0,000 0,03296362 0,08705961 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03296362 0,08696559 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03296362 0,08687177 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03296362 0,08677816 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03296362 0,08668475 ! protein refolding GO:0042026 15 6 0,000 0,03296362 0,08659154 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03296362 0,08649853 ! opsonization GO:0008228 8 6 0,000 0,03296362 0,08640572 ! mating behavior GO:0007617 7 6 0,000 0,03296362 0,08631311 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03296362 0,0862207 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,03296362 0,08612849 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03296362 0,08603647 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03296362 0,08594465 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03296362 0,08585302 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03296362 0,08576159 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03296362 0,08567036 ! toxin metabolic process GO:0009404 11 6 0,000 0,03296362 0,08557931 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03296362 0,08548847 ! nuclear migration GO:0007097 13 6 0,000 0,03296362 0,08539781 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03296362 0,08530735 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03296362 0,08521707 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03296362 0,08512699 ! thymic T cell selection GO:0045061 16 6 0,000 0,03296362 0,0850371 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03296362 0,0849474 ! protein lipoylation GO:0009249 10 6 0,000 0,03296362 0,08485789 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03296362 0,08476856 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03296362 0,08467943 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03296362 0,08459048 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03296362 0,08450172 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03296362 0,08441314 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03296362 0,08432475 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03296362 0,08423654 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! response to pH GO:0009268 10 6 0,000 0,03296362 0,08414852 ! hyperosmotic response GO:0006972 10 6 0,000 0,03296362 0,08406068 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03296362 0,08397303 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03296362 0,08388556 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03296362 0,08379827 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03296362 0,08371116 ! urea metabolic process GO:0019627 7 6 0,000 0,03296362 0,08362423 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03296362 0,08353748 ! neutrophil activation GO:0042119 7 6 0,000 0,03296362 0,08345092 ! regulation of appetite GO:0032098 10 6 0,000 0,03296362 0,08336453 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03296362 0,08327832 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03296362 0,08319229 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03296362 0,08310643 ! neuron apoptosis GO:0051402 15 6 0,000 0,03296362 0,08302076 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03296362 0,08293526 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03296362 0,08284993 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03296362 0,08276478 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03296362 0,08267981 ! carnitine transport GO:0015879 10 6 0,000 0,03296362 0,08259501 GO:0015838|betaine transport, ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03296362 0,08251038 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03296362 0,08242593 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03296362 0,08234165 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03296362 0,08225754 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03296362 0,08217361 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03296362 0,08208984 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03296362 0,08200625 ! neural nucleus development GO:0048857 19 6 0,000 0,03296362 0,08192282 ! response to UV-C GO:0010225 14 6 0,000 0,03296362 0,08183957 ! astrocyte development GO:0014002 16 6 0,000 0,03296362 0,08175648 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03296362 0,08167356 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03296362 0,08159082 ! interaction with symbiont GO:0051702 14 6 0,000 0,03296362 0,08150823 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03296362 0,08142582 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03296362 0,08134357 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03296362 0,08126149 ! response to copper ion GO:0046688 10 6 0,000 0,03296362 0,08117957 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03296362 0,08109782 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03296362 0,08101623 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03296362 0,08093481 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03296362 0,08085355 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03296362 0,08077245 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03296362 0,08069152 ! hair follicle maturation GO:0048820 8 6 0,000 0,03296362 0,08061075 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03296362 0,08053013 ! Schwann cell development GO:0014044 15 6 0,000 0,03296362 0,08044969 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03296362 0,0803694 ! response to pheromone GO:0019236 6 6 0,000 0,03296362 0,08028927 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03296362 0,0802093 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03296362 0,08012949 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,03296362 0,08004984 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03296362 0,07997034 ! subpallium development GO:0021544 15 6 0,000 0,03296362 0,07989101 ! neural tube patterning GO:0021532 8 6 0,000 0,03296362 0,07981183 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03296362 0,07973281 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03296362 0,07965394 ! G2 phase GO:0051319 16 6 0,000 0,03296362 0,07957523 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03296362 0,07949668 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03296362 0,07941828 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03296362 0,07934003 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03296362 0,07926194 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03296362 0,07918401 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03296362 0,07910622 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03296362 0,07902859 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03296362 0,07895111 ! receptor internalization GO:0031623 11 6 0,000 0,03296362 0,07887379 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03296362 0,07879661 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03296362 0,07871958 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03296362 0,07864271 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 16 6 0,000 0,03296362 0,07856599 ! protein destabilization GO:0031648 9 6 0,000 0,03296362 0,07848941 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03296362 0,07841298 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03296362 0,07833671 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03296362 0,07826058 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03296362 0,0781846 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03296362 0,07810876 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03296362 0,07803308 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03296362 0,07795754 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03296362 0,07788214 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03296362 0,07780689 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03296362 0,07773179 ! neural plate development GO:0001840 9 6 0,000 0,03296362 0,07765683 ! catecholamine transport GO:0051937 9 6 0,000 0,03296362 0,07758202 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03296362 0,07750735 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03296362 0,07743282 ! maternal placenta development GO:0001893 12 6 0,000 0,03296362 0,07735844 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03296362 0,0772842 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03296362 0,0772101 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03296362 0,07713614 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03296362 0,07706233 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03296362 0,07698866 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,03412333 0,07962111 ! amino acid activation GO:0043038 98 52 1,000 0,03412333 0,07954513 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,03533406 0,08228895 ! synapse organization GO:0050808 102 53 1,000 0,03533406 0,08221058 ! regulation of translational initiation GO:0006446 87 54 1,000 0,03656126 0,08498492 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,03656126 0,08490414 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 1,000 0,03656126 0,0848235 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,0378047 0,08762513 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,0378047 0,08754208 ! cell recognition GO:0008037 98 55 1,000 0,0378047 0,08745918 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,0378047 0,08737643 ! response to UV GO:0009411 120 55 1,000 0,0378047 0,08729385 ! tRNA transcription GO:0009304 17 7 0,000 0,03835147 0,08847275 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03835147 0,08838928 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03835147 0,08830597 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03835147 0,08822282 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03835147 0,08813983 ! sleep GO:0030431 16 7 0,000 0,03835147 0,08805699 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03835147 0,08797431 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03835147 0,08789178 ! prostate gland development GO:0030850 14 7 0,000 0,03835147 0,08780941 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03835147 0,08772719 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03835147 0,08764512 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03835147 0,08756321 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03835147 0,08748145 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03835147 0,08739985 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03835147 0,0873184 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03835147 0,08723709 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03835147 0,08715594 ! glycolipid transport GO:0046836 11 7 0,000 0,03835147 0,08707494 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03835147 0,08699409 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,03835147 0,08691339 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,03835147 0,08683284 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03835147 0,08675244 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03835147 0,08667219 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03835147 0,08659209 ! mRNA stabilization GO:0048255 18 7 0,000 0,03835147 0,08651213 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,03835147 0,08643232 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03835147 0,08635266 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03835147 0,08627315 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03835147 0,08619378 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03835147 0,08611456 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03835147 0,08603548 ! rhythmic behavior GO:0007622 17 7 0,000 0,03835147 0,08595655 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03835147 0,08587776 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03835147 0,08579912 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03835147 0,08572062 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03835147 0,08564226 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03835147 0,08556405 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03835147 0,08548598 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03835147 0,08540806 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03835147 0,08533027 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03835147 0,08525263 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03835147 0,08517513 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03835147 0,08509776 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03835147 0,08502054 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03835147 0,08494346 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03835147 0,08486652 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03835147 0,08478972 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03835147 0,08471305 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03835147 0,08463653 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03835147 0,08456014 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03835147 0,08448389 ! adrenal gland development GO:0030325 17 7 0,000 0,03835147 0,08440778 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03835147 0,08433181 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03835147 0,08425597 ! ovulation GO:0030728 10 7 0,000 0,03835147 0,08418027 ! adenohypophysis development GO:0021984 11 7 0,000 0,03835147 0,0841047 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03835147 0,08402927 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03835147 0,08395398 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03835147 0,08387882 ! microtubule nucleation GO:0007020 21 7 0,000 0,03835147 0,08380379 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03835147 0,0837289 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03835147 0,08365414 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03835147 0,08357952 ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03835147 0,08350502 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03835147 0,08343067 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03835147 0,08335644 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03835147 0,08328234 ! galactose metabolic process GO:0006012 13 7 0,000 0,03835147 0,08320838 ! vesicle fusion GO:0006906 20 7 0,000 0,03835147 0,08313455 ! response to dietary excess GO:0002021 8 7 0,000 0,03835147 0,08306085 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03835147 0,08298728 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03835147 0,08291384 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03835147 0,08284053 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03835147 0,08276735 ! organ growth GO:0035265 15 7 0,000 0,03835147 0,0826943 ! nucleoside transport GO:0015858 11 7 0,000 0,03835147 0,08262137 ! nucleoside salvage GO:0043174 11 7 0,000 0,03835147 0,08254858 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03835147 0,08247591 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03835147 0,08240338 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03835147 0,08233096 ! parturition GO:0007567 16 7 0,000 0,03835147 0,08225868 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03835147 0,08218652 ! rRNA modification GO:0000154 14 7 0,000 0,03835147 0,08211449 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03835147 0,08204259 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03835147 0,08197081 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03835147 0,08189916 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03835147 0,08182763 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03835147 0,08175623 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03835147 0,08168495 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03835147 0,0816138 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03835147 0,08154277 ! fibrinolysis GO:0042730 11 7 0,000 0,03835147 0,08147186 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03835147 0,08140108 ! eating behavior GO:0042755 8 7 0,000 0,03835147 0,08133041 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03835147 0,08125988 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03835147 0,08118946 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03835147 0,08111917 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03835147 0,08104899 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03835147 0,08097894 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03835147 0,08090901 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03835147 0,0808392 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03835147 0,08076952 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03835147 0,08069995 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03835147 0,0806305 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03835147 0,08056117 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03835147 0,08049196 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03835147 0,08042287 ! histone ubiquitination GO:0016574 9 7 0,000 0,03835147 0,08035389 ! regulation of meiosis GO:0040020 12 7 0,000 0,03835147 0,08028504 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03835147 0,0802163 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03835147 0,08014768 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03835147 0,08007918 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03835147 0,08001079 ! transcription termination GO:0006353 14 7 0,000 0,03835147 0,07994252 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03835147 0,07987437 ! anaphase GO:0051322 18 7 0,000 0,03835147 0,07980634 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03835147 0,07973842 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03835147 0,07967061 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03835147 0,07960292 ! diuresis GO:0030146 12 7 0,000 0,03835147 0,07953535 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03835147 0,07946789 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03835147 0,07940054 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03835147 0,07933331 ! antibiotic transport GO:0042891 9 7 0,000 0,03835147 0,07926619 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03835147 0,07919919 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03835147 0,0791323 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03835147 0,07906552 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03835147 0,07899885 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03835147 0,0789323 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03835147 0,07886586 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03835147 0,07879953 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03835147 0,07873331 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03835147 0,0786672 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03835147 0,07860121 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03835147 0,07853532 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03835147 0,07846955 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03835147 0,07840388 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03835147 0,07833833 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03835147 0,07827288 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03835147 0,07820754 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03835147 0,07814232 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03835147 0,0780772 ! retina homeostasis GO:0001895 12 7 0,000 0,03835147 0,07801219 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03835147 0,07794729 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03835147 0,07788249 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03835147 0,07781781 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,03906418 0,07919817 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,03906418 0,0791325 ! muscle fiber development GO:0048747 131 57 1,000 0,04033948 0,08164817 ! heart morphogenesis GO:0003007 105 57 1,000 0,04033948 0,08158058 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,04033948 0,08151311 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,04033948 0,08144574 ! regulation of actin filament length GO:0030832 118 58 1,000 0,04163038 0,08398267 ! gastrulation GO:0007369 122 58 1,000 0,04163038 0,08391338 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,04163038 0,0838442 ! establishment of organelle localization GO:0051656 122 59 1,000 0,04293667 0,08640386 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04370945 0,08788656 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04370945 0,08781429 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,04370945 0,08774213 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04370945 0,08767009 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04370945 0,08759817 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04370945 0,08752637 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04370945 0,08745469 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04370945 0,08738312 ! male meiosis GO:0007140 9 8 0,000 0,04370945 0,08731167 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04370945 0,08724034 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04370945 0,08716912 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04370945 0,08709802 ! meiotic prophase I GO:0007128 14 8 0,000 0,04370945 0,08702704 ! response to zinc ion GO:0010043 12 8 0,000 0,04370945 0,08695617 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,04370945 0,08688541 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04370945 0,08681478 ! oligopeptide transport GO:0006857 16 8 0,000 0,04370945 0,08674425 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04370945 0,08667384 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04370945 0,08660355 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04370945 0,08653337 ! signal peptide processing GO:0006465 12 8 0,000 0,04370945 0,0864633 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04370945 0,08639334 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04370945 0,0863235 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04370945 0,08625378 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04370945 0,08618416 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04370945 0,08611466 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04370945 0,08604527 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04370945 0,08597599 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04370945 0,08590682 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04370945 0,08583776 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04370945 0,08576881 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04370945 0,08569998 ! reflex GO:0060004 17 8 0,000 0,04370945 0,08563125 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04370945 0,08556264 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04370945 0,08549413 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04370945 0,08542574 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04370945 0,08535745 ! pigment granule organization GO:0048753 17 8 0,000 0,04370945 0,08528928 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04370945 0,08522121 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04370945 0,08515325 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04370945 0,0850854 ! histidine catabolic process GO:0006548 10 8 0,000 0,04370945 0,08501765 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04370945 0,08495002 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04370945 0,08488249 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04370945 0,08481507 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04370945 0,08474776 ! melanin metabolic process GO:0006582 17 8 0,000 0,04370945 0,08468055 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04370945 0,08461345 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04370945 0,08454646 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04370945 0,08447957 ! macrophage activation GO:0042116 13 8 0,000 0,04370945 0,08441279 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04370945 0,08434611 ! purine salvage GO:0043101 12 8 0,000 0,04370945 0,08427954 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04370945 0,08421307 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04370945 0,08414671 ! osteoblast development GO:0002076 17 8 0,000 0,04370945 0,08408045 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04370945 0,0840143 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04370945 0,08394825 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04370945 0,08388231 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04370945 0,08381646 ! response to UV-B GO:0010224 17 8 0,000 0,04370945 0,08375072 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04370945 0,08368509 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04370945 0,08361956 ! intermediate filament organization GO:0045109 12 8 0,000 0,04370945 0,08355413 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04370945 0,0834888 ! cellular extravasation GO:0045123 13 8 0,000 0,04370945 0,08342357 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04370945 0,08335845 ! response to antibiotic GO:0046677 11 8 0,000 0,04370945 0,08329343 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04370945 0,08322851 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04370945 0,08316369 ! DNA topological change GO:0006265 12 8 0,000 0,04370945 0,08309897 ! response to tropane GO:0014073 15 8 0,000 0,04370945 0,08303435 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04370945 0,08296983 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04370945 0,08290541 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04370945 0,0828411 ! mast cell activation GO:0045576 14 8 0,000 0,04370945 0,08277688 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04370945 0,08271276 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04370945 0,08264874 ! gas homeostasis GO:0033483 14 8 0,000 0,04370945 0,08258482 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04370945 0,082521 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04370945 0,08245728 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04370945 0,08239365 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04370945 0,08233013 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04370945 0,0822667 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04370945 0,08220337 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04370945 0,08214013 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04370945 0,082077 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04370945 0,08201396 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04370945 0,08195102 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04370945 0,08188817 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04370945 0,08182542 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04370945 0,08176277 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04370945 0,08170021 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04370945 0,08163775 ! hormone catabolic process GO:0042447 17 8 0,000 0,04370945 0,08157538 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04370945 0,08151311 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04370945 0,08145093 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04370945 0,08138885 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04370945 0,08132687 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04370945 0,08126497 GO:0010828|positive regulation of glucose transport, ! adult feeding behavior GO:0008343 10 8 0,000 0,04370945 0,08120317 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04370945 0,08114147 ! ATP catabolic process GO:0006200 11 8 0,000 0,04370945 0,08107986 ! blastocyst growth GO:0001832 19 8 0,000 0,04370945 0,08101834 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04370945 0,08095692 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04370945 0,08089559 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04370945 0,08083435 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04370945 0,0807732 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04370945 0,08071215 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04370945 0,08065119 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04370945 0,08059032 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04370945 0,08052954 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04370945 0,08046886 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04370945 0,08040826 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04370945 0,08034776 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04370945 0,08028735 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04370945 0,08022703 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04370945 0,0801668 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04370945 0,08010666 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04370945 0,08004661 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04370945 0,07998665 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04370945 0,07992678 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04370945 0,079867 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04370945 0,07980731 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,04425814 0,0807488 ! positive regulation of secretion GO:0051047 110 61 1,000 0,04559459 0,08312507 ! regulation of cellular component size GO:0032535 125 61 1,000 0,04559459 0,08306308 ! camera-type eye development GO:0043010 126 61 1,000 0,04559459 0,08300118 ! viral reproductive process GO:0022415 132 62 1,000 0,04694581 0,08539733 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,04831159 0,08781639 ! mesoderm development GO:0007498 128 63 1,000 0,04831159 0,08775109 ! axon extension GO:0048675 16 9 0,000 0,04903772 0,08900382 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04903772 0,08893775 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04903772 0,08887177 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04903772 0,08880589 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04903772 0,08874011 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,04903772 0,08867442 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,04903772 0,08860884 ! reproductive behavior GO:0019098 22 9 0,000 0,04903772 0,08854335 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04903772 0,08847795 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,04903772 0,08841265 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04903772 0,08834745 ! UTP metabolic process GO:0046051 10 9 0,000 0,04903772 0,08828235 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04903772 0,08821734 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04903772 0,08815243 ! artery development GO:0060840 25 9 0,000 0,04903772 0,08808761 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04903772 0,08802289 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,04903772 0,08795826 ! equilibrioception GO:0050957 20 9 0,000 0,04903772 0,08789372 ! chemosensory behavior GO:0007635 21 9 0,000 0,04903772 0,08782929 ! microtubule bundle formation GO:0001578 22 9 0,000 0,04903772 0,08776494 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04903772 0,08770069 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04903772 0,08763654 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04903772 0,08757248 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04903772 0,08750851 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04903772 0,08744463 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04903772 0,08738085 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04903772 0,08731716 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04903772 0,08725357 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04903772 0,08719006 ! protein targeting to ER GO:0045047 25 9 0,000 0,04903772 0,08712665 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04903772 0,08706333 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,04903772 0,08700011 ! T cell selection GO:0045058 27 9 0,000 0,04903772 0,08693697 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04903772 0,08687393 ! glycine catabolic process GO:0006546 15 9 0,000 0,04903772 0,08681098 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04903772 0,08674811 ! endosome organization GO:0007032 20 9 0,000 0,04903772 0,08668534 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04903772 0,08662267 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04903772 0,08656008 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04903772 0,08649758 ! mannose metabolic process GO:0006013 13 9 0,000 0,04903772 0,08643517 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04903772 0,08637285 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04903772 0,08631062 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,04903772 0,08624849 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04903772 0,08618644 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04903772 0,08612448 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04903772 0,08606261 ! retinol metabolic process GO:0042572 20 9 0,000 0,04903772 0,08600082 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04903772 0,08593913 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04903772 0,08587752 GO:0007351|tripartite regional subdivision, ! macrophage differentiation GO:0030225 15 9 0,000 0,04903772 0,08581601 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04903772 0,08575458 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,04903772 0,08569324 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04903772 0,08563198 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04903772 0,08557082 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04903772 0,08550974 ! response to amine stimulus GO:0014075 13 9 0,000 0,04903772 0,08544875 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04903772 0,08538785 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04903772 0,08532703 ! erythrocyte development GO:0048821 17 9 0,000 0,04903772 0,0852663 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,04903772 0,08520565 ! renal water homeostasis GO:0003091 15 9 0,000 0,04903772 0,08514509 ! postreplication repair GO:0006301 25 9 0,000 0,04903772 0,08508462 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04903772 0,08502423 ! icosanoid secretion GO:0032309 15 9 0,000 0,04903772 0,08496393 GO:0050482|arachidonic acid secretion, ! regulation of cell division GO:0051302 17 9 0,000 0,04903772 0,08490372 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04903772 0,08484359 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04903772 0,08478354 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04903772 0,08472358 ! sterol catabolic process GO:0016127 14 9 0,000 0,04903772 0,08466371 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04903772 0,08460392 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04903772 0,08454421 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,04903772 0,08448459 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04903772 0,08442505 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,04903772 0,0843656 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04903772 0,08430623 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04903772 0,08424694 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04903772 0,08418773 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04903772 0,08412861 ! purine base metabolic process GO:0006144 25 9 0,000 0,04903772 0,08406958 ! pigment granule transport GO:0051904 17 9 0,000 0,04903772 0,08401062 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04903772 0,08395175 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04903772 0,08389296 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04903772 0,08383425 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,04903772 0,08377563 ! mitochondrion localization GO:0051646 18 9 0,000 0,04903772 0,08371708 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,05108605 0,08715308 ! ear development GO:0043583 114 66 1,000 0,05249432 0,0894931 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 1,000 0,05391635 0,09185331 ! chromosome segregation GO:0007059 127 67 1,000 0,05391635 0,0917893 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05433645 0,09244008 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05433645 0,09237575 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05433645 0,09231151 ! associative learning GO:0008306 21 10 0,000 0,05433645 0,09224736 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,05433645 0,0921833 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05433645 0,09211933 ! phosphate transport GO:0006817 24 10 0,000 0,05433645 0,09205545 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05433645 0,09199165 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05433645 0,09192795 ! CTP metabolic process GO:0046036 11 10 0,000 0,05433645 0,09186433 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,05433645 0,0918008 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,05433645 0,09173736 ! GTP metabolic process GO:0046039 11 10 0,000 0,05433645 0,091674 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05433645 0,09161074 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05433645 0,09154756 ! social behavior GO:0035176 29 10 0,000 0,05433645 0,09148446 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05433645 0,09142146 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 17 10 0,000 0,05433645 0,09135854 ! phospholipid efflux GO:0033700 19 10 0,000 0,05433645 0,09129571 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05433645 0,09123296 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,05433645 0,0911703 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,05433645 0,09110772 ! lung alveolus development GO:0048286 26 10 0,000 0,05433645 0,09104524 ! pathogenesis GO:0009405 17 10 0,000 0,05433645 0,09098283 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,05433645 0,09092052 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05433645 0,09085829 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,05433645 0,09079614 ! endoderm development GO:0007492 18 10 0,000 0,05433645 0,09073408 ! arginine catabolic process GO:0006527 17 10 0,000 0,05433645 0,0906721 ! proline metabolic process GO:0006560 13 10 0,000 0,05433645 0,09061021 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05433645 0,0905484 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05433645 0,09048668 ! V(D)J recombination GO:0033151 34 10 0,000 0,05433645 0,09042504 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05433645 0,09036348 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,05433645 0,09030201 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05433645 0,09024062 ! B cell proliferation GO:0042100 19 10 0,000 0,05433645 0,09017932 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,05433645 0,0901181 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05433645 0,09005696 ! multicellular organism growth GO:0035264 19 10 0,000 0,05433645 0,0899959 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05433645 0,08993493 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05433645 0,08987404 ! ruffle organization GO:0031529 17 10 0,000 0,05433645 0,08981323 ! epithelial cell development GO:0002064 21 10 0,000 0,05433645 0,08975251 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05433645 0,08969186 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05433645 0,0896313 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05433645 0,08957082 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05433645 0,08951042 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05433645 0,0894501 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05433645 0,08938987 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,05433645 0,08932971 ! regulation of bone resorption GO:0045124 25 10 0,000 0,05433645 0,08926964 ! brain morphogenesis GO:0048854 23 10 0,000 0,05433645 0,08920965 ! segment specification GO:0007379 15 10 0,000 0,05433645 0,08914973 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05433645 0,0890899 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05433645 0,08903015 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05433645 0,08897048 ! DNA ligation GO:0006266 18 10 0,000 0,05433645 0,08891089 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05433645 0,08885138 ! melanosome localization GO:0032400 16 10 0,000 0,05433645 0,08879194 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05433645 0,08873259 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05433645 0,08867332 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05433645 0,08861412 ! induction of an organ GO:0001759 17 10 0,000 0,05433645 0,08855501 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05433645 0,08849597 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05433645 0,08843701 ! protein sumoylation GO:0016925 17 10 0,000 0,05433645 0,08837813 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05433645 0,08831933 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05433645 0,08826061 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05433645 0,08820196 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05433645 0,0881434 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! midbrain development GO:0030901 14 10 0,000 0,05433645 0,08808491 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05433645 0,0880265 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05433645 0,08796816 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05433645 0,0879099 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05433645 0,08785172 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05433645 0,08779362 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05433645 0,08773559 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05433645 0,08767765 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05433645 0,08761977 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05433645 0,08756198 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05433645 0,08750426 ! blastocyst formation GO:0001825 18 10 0,000 0,05433645 0,08744661 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05433645 0,08738904 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05433645 0,08733155 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05433645 0,08727413 ! response to nicotine GO:0035094 20 10 0,000 0,05433645 0,08721679 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05433645 0,08715952 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05433645 0,08710233 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,05535196 0,08867202 ! viral reproduction GO:0016032 142 68 1,000 0,05535196 0,08861391 ! regulation of lipase activity GO:0060191 137 68 1,000 0,05535196 0,08855588 ! adaptive immune response GO:0002250 126 68 1,000 0,05535196 0,08849793 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,05535196 0,08844005 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,05680094 0,09069588 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,05680094 0,09063664 ! cellular amino acid catabolic process GO:0009063 120 69 1,000 0,05680094 0,09057748 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05960581 0,09498826 ! respiratory burst GO:0045730 17 11 0,000 0,05960581 0,09492633 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05960581 0,09486449 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05960581 0,09480273 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05960581 0,09474105 ! thyroid gland development GO:0030878 26 11 0,000 0,05960581 0,09467945 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,05960581 0,09461793 ! synapsis GO:0007129 14 11 0,000 0,05960581 0,09455649 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05960581 0,09449513 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05960581 0,09443385 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,05960581 0,09437265 ! response to pain GO:0048265 27 11 0,000 0,05960581 0,09431153 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,05960581 0,09425048 ! bone resorption GO:0045453 16 11 0,000 0,05960581 0,09418952 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05960581 0,09412863 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,05960581 0,09406783 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05960581 0,0940071 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05960581 0,09394645 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05960581 0,09388588 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05960581 0,09382539 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05960581 0,09376497 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05960581 0,09370463 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05960581 0,09364437 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05960581 0,09358419 ! UV protection GO:0009650 20 11 0,000 0,05960581 0,09352408 ! adult heart development GO:0007512 16 11 0,000 0,05960581 0,09346406 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05960581 0,0934041 ! macroautophagy GO:0016236 19 11 0,000 0,05960581 0,09334423 ! temperature homeostasis GO:0001659 18 11 0,000 0,05960581 0,09328443 ! behavioral fear response GO:0001662 27 11 0,000 0,05960581 0,09322471 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05960581 0,09316507 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,05960581 0,0931055 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05960581 0,093046 ! regulation of organ growth GO:0046620 14 11 0,000 0,05960581 0,09298659 ! pigment granule localization GO:0051875 20 11 0,000 0,05960581 0,09292725 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,05960581 0,09286798 ! vasoconstriction GO:0042310 20 11 0,000 0,05960581 0,09280879 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05960581 0,09274968 ! embryonic axis specification GO:0000578 19 11 0,000 0,05960581 0,09269064 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05960581 0,09263168 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05960581 0,09257279 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05960581 0,09251398 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05960581 0,09245524 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,05960581 0,09239657 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05960581 0,09233798 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05960581 0,09227947 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05960581 0,09222102 ! prophase GO:0051324 17 11 0,000 0,05960581 0,09216266 ! nucleosome positioning GO:0016584 15 11 0,000 0,05960581 0,09210436 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05960581 0,09204614 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05960581 0,091988 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05960581 0,09192992 ! apical protein localization GO:0045176 18 11 0,000 0,05960581 0,09187192 ! acid secretion GO:0046717 20 11 0,000 0,05960581 0,091814 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05960581 0,09175614 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05960581 0,09169836 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05960581 0,09164065 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,05960581 0,09158302 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05960581 0,09152545 ! oocyte development GO:0048599 20 11 0,000 0,05960581 0,09146796 ! germ cell migration GO:0008354 26 11 0,000 0,05960581 0,09141054 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05960581 0,0913532 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05960581 0,09129592 ! activation of innate immune response GO:0002218 16 11 0,000 0,05960581 0,09123872 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05960581 0,09118159 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05960581 0,09112453 ! lysogeny GO:0030069 22 11 0,000 0,05960581 0,09106754 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05960581 0,09101062 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,05960581 0,09095378 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05960581 0,090897 ! nucleus localization GO:0051647 22 11 0,000 0,05960581 0,0908403 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,05973827 0,09098541 ! carbohydrate transport GO:0008643 114 72 1,000 0,06122624 0,09319359 ! B cell activation GO:0042113 179 72 1,000 0,06122624 0,09313556 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,06122624 0,09307761 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,06122624 0,09301972 ! humoral immune response GO:0006959 115 73 1,000 0,06272683 0,09524031 ! regulation of immune effector process GO:0002697 156 73 1,000 0,06272683 0,09518115 ! acute inflammatory response GO:0002526 118 74 1,000 0,06423986 0,0974165 ! organelle localization GO:0051640 155 74 1,000 0,06423986 0,09735606 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06484596 0,09821368 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06484596 0,09815283 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06484596 0,09809206 ! mating GO:0007618 17 12 0,000 0,06484596 0,09803136 ! protein complex disassembly GO:0043241 28 12 0,000 0,06484596 0,09797073 GO:0043624|cellular protein complex disassembly, ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06484596 0,09791018 ! T cell proliferation GO:0042098 32 12 0,000 0,06484596 0,0978497 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06484596 0,0977893 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06484596 0,09772898 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06484596 0,09766872 ! drug transport GO:0015893 16 12 0,000 0,06484596 0,09760855 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06484596 0,09754844 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06484596 0,09748841 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06484596 0,09742846 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06484596 0,09736857 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06484596 0,09730877 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06484596 0,09724903 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06484596 0,09718937 ! lipid digestion GO:0044241 21 12 0,000 0,06484596 0,09712978 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06484596 0,09707026 ! entry into host cell GO:0030260 34 12 0,000 0,06484596 0,09701082 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06484596 0,09695145 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06484596 0,09689215 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06484596 0,09683293 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06484596 0,09677378 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06484596 0,0967147 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06484596 0,09665569 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06484596 0,09659675 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06484596 0,09653789 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06484596 0,09647909 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06484596 0,09642037 ! fucose catabolic process GO:0019317 25 12 0,000 0,06484596 0,09636172 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06484596 0,09630314 ! histone acetylation GO:0016573 27 12 0,000 0,06484596 0,09624464 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,06484596 0,0961862 ! zymogen activation GO:0031638 18 12 0,000 0,06484596 0,09612783 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,06484596 0,09606954 ! T cell homeostasis GO:0043029 28 12 0,000 0,06484596 0,09601132 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06484596 0,09595316 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06484596 0,09589508 ! oocyte differentiation GO:0009994 21 12 0,000 0,06484596 0,09583707 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06484596 0,09577912 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06484596 0,09572125 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,06484596 0,09566345 ! defense response to fungus GO:0050832 15 12 0,000 0,06484596 0,09560572 ! developmental induction GO:0031128 22 12 0,000 0,06484596 0,09554805 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,06484596 0,09549046 ! response to cold GO:0009409 17 12 0,000 0,06484596 0,09543293 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06484596 0,09537548 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06484596 0,09531809 ! localization within membrane GO:0051668 26 12 0,000 0,06484596 0,09526078 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,06576513 0,09655302 ! eye development GO:0001654 155 75 1,000 0,06576513 0,09649503 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,06730248 0,09869145 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,06730248 0,09863225 ! learning or memory GO:0007611 161 76 1,000 0,06730248 0,09857312 ! amine catabolic process GO:0009310 136 77 1,000 0,06885171 0,10078175 ! neurotransmitter transport GO:0006836 142 77 1,000 0,06885171 0,1007214 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,06885171 0,10066112 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,06885171 0,10060092 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,07005705 0,10230088 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07005705 0,10223977 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07005705 0,10217873 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07005705 0,10211776 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,07005705 0,10205687 ! peroxisomal transport GO:0043574 28 13 0,000 0,07005705 0,10199605 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07005705 0,1019353 ! cartilage condensation GO:0001502 22 13 0,000 0,07005705 0,10187462 ! organelle fusion GO:0048284 36 13 0,000 0,07005705 0,10181402 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07005705 0,10175349 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07005705 0,10169303 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07005705 0,10163264 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07005705 0,10157232 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07005705 0,10151208 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07005705 0,10145191 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07005705 0,1013918 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,07005705 0,10133177 ! methionine metabolic process GO:0006555 31 13 0,000 0,07005705 0,10127181 ! plasma membrane organization GO:0007009 27 13 0,000 0,07005705 0,10121193 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,07005705 0,10115211 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07005705 0,10109236 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,07005705 0,10103268 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,07005705 0,10097308 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,07005705 0,10091354 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,07005705 0,10085408 ! asymmetric protein localization GO:0008105 24 13 0,000 0,07005705 0,10079468 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07005705 0,10073535 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07005705 0,1006761 ! L-glutamate transport GO:0015813 30 13 0,000 0,07005705 0,10061691 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,07005705 0,10055779 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07005705 0,10049875 ! protein homotetramerization GO:0051289 24 13 0,000 0,07005705 0,10043977 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07005705 0,10038086 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07005705 0,10032202 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07005705 0,10026325 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07005705 0,10020455 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,07005705 0,10014591 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07005705 0,10008735 ! histone methylation GO:0016571 29 13 0,000 0,07005705 0,10002885 ! chromatin silencing GO:0006342 29 13 0,000 0,07005705 0,09997042 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,07005705 0,09991206 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07005705 0,09985377 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07005705 0,09979555 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,07005705 0,09973739 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07005705 0,09967931 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07005705 0,09962128 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,07005705 0,09956333 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07005705 0,09950545 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,07005705 0,09944763 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07005705 0,09938988 ! insulin secretion GO:0030073 24 13 0,000 0,07005705 0,09933219 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07005705 0,09927457 ! acrosome reaction GO:0007340 19 13 0,000 0,07005705 0,09921702 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,07005705 0,09915954 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,07005705 0,09910212 ! blood coagulation GO:0007596 151 79 1,000 0,07198514 0,10177066 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,07198514 0,10171179 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,07356897 0,1038896 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,07356897 0,10382958 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,07356897 0,10376963 ! rRNA transcription GO:0009303 28 14 0,000 0,07523925 0,10606433 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07523925 0,10600316 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07523925 0,10594206 ! water transport GO:0006833 21 14 0,000 0,07523925 0,10588104 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07523925 0,10582008 ! non-recombinational repair GO:0000726 29 14 0,000 0,07523925 0,10575919 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07523925 0,10569838 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07523925 0,10563763 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,07523925 0,10557695 ! palate development GO:0060021 32 14 0,000 0,07523925 0,10551635 ! regulated secretory pathway GO:0045055 24 14 0,000 0,07523925 0,10545581 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07523925 0,10539534 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07523925 0,10533494 ! arginine metabolic process GO:0006525 21 14 0,000 0,07523925 0,10527462 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07523925 0,10521436 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,07523925 0,10515416 ! regulation of heart rate GO:0002027 25 14 0,000 0,07523925 0,10509404 ! fear response GO:0042596 34 14 0,000 0,07523925 0,10503399 ! organic alcohol transport GO:0015850 29 14 0,000 0,07523925 0,104974 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07523925 0,10491409 ! embryo implantation GO:0007566 30 14 0,000 0,07523925 0,10485424 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07523925 0,10479446 ! bone mineralization GO:0030282 18 14 0,000 0,07523925 0,10473475 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07523925 0,1046751 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07523925 0,10461553 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,07523925 0,10455602 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07523925 0,10449658 ! ribosome assembly GO:0042255 18 14 0,000 0,07523925 0,1044372 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07523925 0,1043779 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07523925 0,10431866 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07523925 0,10425949 ! NADP metabolic process GO:0006739 24 14 0,000 0,07523925 0,10420038 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07523925 0,10414135 ! oxygen transport GO:0015671 22 14 0,000 0,07523925 0,10408238 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07523925 0,10402347 ! regulation of RNA stability GO:0043487 33 14 0,000 0,07523925 0,10396464 ! regulation of axon extension GO:0030516 43 14 0,000 0,07523925 0,10390587 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07523925 0,10384716 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,07677003 0,10590016 ! response to drug GO:0042493 149 83 1,000 0,0783869 0,10806953 ! response to nutrient GO:0007584 135 84 1,000 0,08001445 0,11025116 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,08039271 0,11070992 ! lactation GO:0007595 30 15 0,000 0,08039271 0,11064755 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,08039271 0,11058524 ! reproductive cellular process GO:0048610 22 15 0,000 0,08039271 0,11052301 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08039271 0,11046085 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,08039271 0,11039876 ! superoxide anion generation GO:0042554 22 15 0,000 0,08039271 0,11033674 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,08039271 0,11027479 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,08039271 0,1102129 ! copper ion transport GO:0006825 22 15 0,000 0,08039271 0,11015109 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,08039271 0,11008935 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,08039271 0,11002767 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,08039271 0,10996607 ! response to cAMP GO:0051591 25 15 0,000 0,08039271 0,10990453 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,08039271 0,10984306 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,08039271 0,10978166 ! response to hexose stimulus GO:0009746 25 15 0,000 0,08039271 0,10972033 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,08039271 0,10965907 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,08039271 0,10959788 ! vesicle coating GO:0006901 38 15 0,000 0,08039271 0,10953675 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,08039271 0,10947569 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,08039271 0,1094147 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,08039271 0,10935378 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,08039271 0,10929293 ! regulation of vasodilation GO:0042312 27 15 0,000 0,08039271 0,10923214 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,08039271 0,10917143 ! histone deacetylation GO:0016575 24 15 0,000 0,08039271 0,10911077 ! water homeostasis GO:0030104 28 15 0,000 0,08039271 0,10905019 ! cofactor transport GO:0051181 30 15 0,000 0,08039271 0,10898968 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08039271 0,10892923 ! muscle maintenance GO:0046716 26 15 0,000 0,08039271 0,10886884 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,08039271 0,10880853 ! intestinal absorption GO:0050892 31 15 0,000 0,08039271 0,10874828 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08039271 0,1086881 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,08039271 0,10862798 ! heme biosynthetic process GO:0006783 33 15 0,000 0,08039271 0,10856794 ! cell killing GO:0001906 32 15 0,000 0,08039271 0,10850795 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,08039271 0,10844804 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,08039271 0,10838819 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,08039271 0,1083284 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,08039271 0,10826869 ! actin filament polymerization GO:0030041 27 15 0,000 0,08039271 0,10820903 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,08039271 0,10814945 ! hemostasis GO:0007599 165 85 1,000 0,0816525 0,10978374 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,0855176 0,11491722 ! positive regulation of cell size GO:0045793 29 16 0,000 0,0855176 0,11485404 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,0855176 0,11479094 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,0855176 0,1147279 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,0855176 0,11466493 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,0855176 0,11460203 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0855176 0,1145392 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,0855176 0,11447644 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,0855176 0,11441375 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,0855176 0,11435112 ! startle response GO:0001964 28 16 0,000 0,0855176 0,11428857 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,0855176 0,11422608 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,0855176 0,11416366 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,0855176 0,11410131 ! protein polyubiquitination GO:0000209 41 16 0,000 0,0855176 0,11403903 ! glutamate metabolic process GO:0006536 25 16 0,000 0,0855176 0,11397682 ! response to osmotic stress GO:0006970 27 16 0,000 0,0855176 0,11391467 ! lysosomal transport GO:0007041 31 16 0,000 0,0855176 0,11385259 ! fructose metabolic process GO:0006000 25 16 0,000 0,0855176 0,11379058 ! L-amino acid transport GO:0015807 33 16 0,000 0,0855176 0,11372864 ! stem cell development GO:0048864 46 16 0,000 0,0855176 0,11366676 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,0855176 0,11360495 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,0855176 0,11354321 ! intermediate filament-based process GO:0045103 36 16 0,000 0,0855176 0,11348153 ! negative regulation of immune response GO:0050777 38 16 0,000 0,0855176 0,11341993 ! axon cargo transport GO:0008088 46 16 0,000 0,0855176 0,11335838 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,0855176 0,11329691 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,0855176 0,1132355 ! DNA replication initiation GO:0006270 28 16 0,000 0,0855176 0,11317416 ! mRNA splice site selection GO:0006376 44 16 0,000 0,0855176 0,11311289 ! tissue regeneration GO:0042246 27 16 0,000 0,0855176 0,11305168 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,0855176 0,11299054 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,0855176 0,11292946 ! biomineral formation GO:0031214 22 16 0,000 0,0855176 0,11286845 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,0855176 0,11280751 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,0855176 0,11274663 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,0855176 0,11268582 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,0855176 0,11262507 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,0855176 0,11256439 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,0855176 0,11250377 ! peptide hormone processing GO:0016486 27 16 0,000 0,0855176 0,11244322 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,09061408 0,11908025 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,09061408 0,11901623 ! filopodium assembly GO:0046847 42 17 0,000 0,09061408 0,11895228 ! gene silencing by RNA GO:0031047 38 17 0,000 0,09061408 0,11888839 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,09061408 0,11882458 ! glial cell development GO:0021782 28 17 0,000 0,09061408 0,11876083 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,09061408 0,11869715 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,09061408 0,11863354 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,09061408 0,11857 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,09061408 0,11850652 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,09061408 0,11844312 ! myoblast differentiation GO:0045445 50 17 0,000 0,09061408 0,11837978 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,09061408 0,11831651 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,09061408 0,11825331 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,09061408 0,11819017 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,09061408 0,1181271 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,09061408 0,1180641 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,09061408 0,11800117 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,09061408 0,1179383 ! membrane budding GO:0006900 42 17 0,000 0,09061408 0,1178755 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,09061408 0,11781277 ! regulation of protein binding GO:0043393 33 17 0,000 0,09061408 0,1177501 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,09061408 0,1176875 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,09061408 0,11762497 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,09061408 0,1175625 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,09061408 0,1175001 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,09061408 0,11743777 ! steroid catabolic process GO:0006706 34 17 0,000 0,09061408 0,1173755 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,09061408 0,1173133 ! gas transport GO:0015669 26 17 0,000 0,09061408 0,11725116 ! organic cation transport GO:0015695 32 17 0,000 0,09061408 0,11718909 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,09061408 0,11712708 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,09061408 0,11706514 ! defense response to bacterium GO:0042742 112 91 1,000 0,09169221 0,11839538 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,09568229 0,12348221 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,09568229 0,12341702 ! adult walking behavior GO:0007628 36 18 0,000 0,09568229 0,12335189 ! patterning of blood vessels GO:0001569 43 18 0,000 0,09568229 0,12328683 ! heart looping GO:0001947 34 18 0,000 0,09568229 0,12322184 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,09568229 0,12315692 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,09568229 0,12309207 ! centrosome cycle GO:0007098 26 18 0,000 0,09568229 0,12302728 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,09568229 0,12296256 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,09568229 0,12289791 ! glycine metabolic process GO:0006544 30 18 0,000 0,09568229 0,12283333 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09568229 0,12276882 ! response to retinoic acid GO:0032526 31 18 0,000 0,09568229 0,12270437 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,09568229 0,12264 ! DNA integration GO:0015074 32 18 0,000 0,09568229 0,12257569 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,09568229 0,12251144 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,09568229 0,12244727 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,09568229 0,12238316 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,09568229 0,12231912 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,09568229 0,12225514 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,09568229 0,12219124 ! detection of bacterium GO:0016045 22 18 0,000 0,09568229 0,12212739 ! microspike assembly GO:0030035 46 18 0,000 0,09568229 0,12206362 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,09568229 0,12199991 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,09568229 0,12193627 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,09684075 0,12334826 ! regulation of membrane potential GO:0042391 179 94 1,000 0,09684075 0,12328398 ! sex differentiation GO:0007548 171 96 1,000 0,10031792 0,12764411 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,1007224 0,12809205 ! negative regulation of defense response GO:0031348 27 19 0,000 0,1007224 0,1280254 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,1007224 0,12795882 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,1007224 0,12789232 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,1007224 0,12782588 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,1007224 0,12775951 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,1007224 0,12769321 ! inositol metabolic process GO:0006020 33 19 0,000 0,1007224 0,12762698 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,1007224 0,12756082 ! memory GO:0007613 34 19 0,000 0,1007224 0,12749472 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,1007224 0,1274287 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,1007224 0,12736274 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,1007224 0,12729685 ! cerebral cortex development GO:0021987 40 19 0,000 0,1007224 0,12723103 ! response to vitamin A GO:0033189 32 19 0,000 0,1007224 0,12716528 ! heme metabolic process GO:0042168 40 19 0,000 0,1007224 0,1270996 ! response to fungus GO:0009620 26 19 0,000 0,1007224 0,12703398 ! peptide cross-linking GO:0018149 39 19 0,000 0,1007224 0,12696843 ! protein export from nucleus GO:0006611 40 19 0,000 0,1007224 0,12690295 ! heart process GO:0003015 32 19 0,000 0,1007224 0,12683754 GO:0060047|heart contraction, ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,1007224 0,12677219 ! visual learning GO:0008542 38 19 0,000 0,1007224 0,12670691 ! cellular pigmentation GO:0033059 37 19 0,000 0,1007224 0,1266417 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,1007224 0,12657655 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,1007224 0,12651147 ! vitamin transport GO:0051180 31 19 0,000 0,1007224 0,12644646 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,1007224 0,12638152 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,1007224 0,12631664 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,1007224 0,12625183 ! cilium assembly GO:0042384 38 19 0,000 0,1007224 0,12618709 ! transcription initiation GO:0006352 171 97 1,000 0,1020695 0,12780921 ! protein secretion GO:0009306 45 20 0,000 0,10573456 0,1323307 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,10573456 0,13226294 ! positive regulation of ossification GO:0045778 50 20 0,000 0,10573456 0,13219525 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,10573456 0,13212763 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,10573456 0,13206008 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,10573456 0,1319926 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,10573456 0,13192519 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,10573456 0,13185785 ! response to vitamin GO:0033273 36 20 0,000 0,10573456 0,13179057 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,10573456 0,13172337 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,10573456 0,13165623 ! bile acid metabolic process GO:0008206 34 20 0,000 0,10573456 0,13158916 ! retinoid metabolic process GO:0001523 34 20 0,000 0,10573456 0,13152216 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,10573456 0,13145523 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,10573456 0,13138836 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,10573456 0,13132157 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,10573456 0,13125484 ! body fluid secretion GO:0007589 33 20 0,000 0,10573456 0,13118818 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,10573456 0,13112159 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,10573456 0,13105506 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,10573456 0,1309886 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,10573456 0,13092221 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,10573456 0,13085589 ! cell-cell junction organization GO:0045216 43 20 0,000 0,10573456 0,13078963 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,10573456 0,13072344 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,10573456 0,13065732 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,10573456 0,13059127 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,10573456 0,13052528 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,10573456 0,13045936 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,10573456 0,1303935 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,10737438 0,13234895 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 1,000 0,10737438 0,13228221 ! regulation of cell killing GO:0031341 46 21 0,000 0,11071892 0,13633383 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,11071892 0,13626515 ! lipid phosphorylation GO:0046834 43 21 0,000 0,11071892 0,13619654 ! cAMP metabolic process GO:0046058 41 21 0,000 0,11071892 0,136128 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,11071892 0,13605952 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,11071892 0,13599111 ! ovarian follicle development GO:0001541 39 21 0,000 0,11071892 0,13592278 ! smooth muscle contraction GO:0006939 48 21 0,000 0,11071892 0,13585451 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,11071892 0,13578631 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,11071892 0,13571818 ! plasma membrane fusion GO:0045026 33 21 0,000 0,11071892 0,13565011 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,11071892 0,13558212 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,11071892 0,13551419 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,11071892 0,13544633 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,11071892 0,13537854 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,11071892 0,13531082 ! collagen catabolic process GO:0030574 29 21 0,000 0,11071892 0,13524316 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,11071892 0,13517558 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,11071892 0,13510806 ! actin filament-based movement GO:0030048 47 21 0,000 0,11071892 0,1350406 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,11567564 0,14101577 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,11567564 0,14094544 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,11567564 0,14087517 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,11567564 0,14080498 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,11567564 0,14073486 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 59 22 0,000 0,11567564 0,14066481 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,11567564 0,14059483 ! vacuolar transport GO:0007034 41 22 0,000 0,11567564 0,14052491 ! central nervous system neuron development GO:0021954 47 22 0,000 0,11567564 0,14045507 ! fucose metabolic process GO:0006004 44 22 0,000 0,11567564 0,1403853 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,11567564 0,14031559 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,11567564 0,14024596 ! stem cell differentiation GO:0048863 57 22 0,000 0,11567564 0,14017639 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,11567564 0,14010689 ! cytolysis GO:0019835 27 22 0,000 0,11567564 0,14003746 ! vasodilation GO:0042311 40 22 0,000 0,11567564 0,1399681 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,11567564 0,13989881 ! G1 phase GO:0051318 44 22 0,000 0,11567564 0,13982959 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,11567564 0,13976043 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,11567564 0,13969135 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,11567564 0,13962233 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,11567564 0,13955338 ! sarcomere organization GO:0045214 32 22 0,000 0,11567564 0,1394845 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,11567564 0,13941569 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,11567564 0,13934694 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,11567564 0,13927826 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,11567564 0,13920965 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,11567564 0,13914111 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,11567564 0,13907264 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,12060488 0,14492755 ! gluconeogenesis GO:0006094 38 23 0,000 0,12060488 0,1448563 ! glycerol metabolic process GO:0006071 40 23 0,000 0,12060488 0,14478512 ! viral genome replication GO:0019079 44 23 0,000 0,12060488 0,14471401 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,12060488 0,14464296 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,12060488 0,14457199 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,12060488 0,14450109 ! regeneration GO:0031099 42 23 0,000 0,12060488 0,14443025 ! axis specification GO:0009798 43 23 0,000 0,12060488 0,14435949 ! visual behavior GO:0007632 46 23 0,000 0,12060488 0,14428879 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,12060488 0,14421817 ! response to ethanol GO:0045471 47 23 0,000 0,12060488 0,14414761 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,12060488 0,14407712 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,12060488 0,1440067 ! peroxisome organization GO:0007031 43 23 0,000 0,12060488 0,14393635 ! lysosome organization GO:0007040 47 23 0,000 0,12060488 0,14386607 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,12060488 0,14379586 ! vesicle targeting GO:0006903 49 23 0,000 0,12060488 0,14372572 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,12060488 0,14365564 GO:0060415|muscle tissue morphogenesis, ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,12060488 0,14358563 ! DNA modification GO:0006304 36 23 0,000 0,12060488 0,14351569 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,12060488 0,14344582 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,12060488 0,14337602 ! cell-cell recognition GO:0009988 28 23 0,000 0,12060488 0,14330628 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,12060488 0,14323661 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,12060488 0,14316701 GO:0006099|tricarboxylic acid cycle, ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,12550677 0,14891357 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,12550677 0,14884129 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,12550677 0,14876907 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,12550677 0,14869692 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,12550677 0,14862484 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,12550677 0,14855283 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,12550677 0,14848089 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,12550677 0,14840903 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,12550677 0,14833723 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,12550677 0,1482655 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,12550677 0,14819384 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,12550677 0,14812224 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,12550677 0,14805072 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,12550677 0,14797927 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,12550677 0,14790789 ! membrane depolarization GO:0051899 45 24 0,000 0,12550677 0,14783657 ! oogenesis GO:0048477 44 24 0,000 0,12550677 0,14776532 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,12550677 0,14769415 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,12550677 0,14762304 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,12550677 0,147552 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,12550677 0,14748102 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,12550677 0,14741012 ! regulation of amine transport GO:0051952 41 24 0,000 0,12550677 0,14733928 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,12550677 0,14726851 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,13038148 0,15291501 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,13038148 0,15284163 ! leukocyte adhesion GO:0007159 55 25 0,000 0,13038148 0,15276833 ! keratinization GO:0031424 37 25 0,000 0,13038148 0,15269509 ! vasculogenesis GO:0001570 49 25 0,000 0,13038148 0,15262193 ! vacuole organization GO:0007033 49 25 0,000 0,13038148 0,15254883 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,13038148 0,15247581 ! chromosome condensation GO:0030261 48 25 0,000 0,13038148 0,15240285 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,13038148 0,15232997 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,13038148 0,15225715 ! immunoglobulin production GO:0002377 62 25 0,000 0,13038148 0,15218441 GO:0002440|production of molecular mediator of immune response, ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,13038148 0,15211173 ! liver development GO:0001889 55 25 0,000 0,13038148 0,15203912 ! initiation of viral infection GO:0019059 60 26 0,000 0,13522915 0,15761681 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,13522915 0,15754164 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,13522915 0,15746655 ! molting cycle process GO:0022404 52 26 0,000 0,13522915 0,15739153 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,13522915 0,15731658 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,13522915 0,15724171 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,13522915 0,1571669 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,13522915 0,15709217 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,13522915 0,1570175 ! digestive system process GO:0022600 49 26 0,000 0,13522915 0,15694291 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,13522915 0,15686839 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,13522915 0,15679394 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,13522915 0,15671956 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,13522915 0,15664525 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,13522915 0,15657101 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,13522915 0,15649684 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,13522915 0,15642274 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,13522915 0,15634871 ! blastocyst development GO:0001824 50 26 0,000 0,13522915 0,15627475 ! telomere organization GO:0032200 46 26 0,000 0,13522915 0,15620086 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,13522915 0,15612704 ! neural tube closure GO:0001843 58 26 0,000 0,13522915 0,15605329 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,13522915 0,15597961 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,13522915 0,155906 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,13522915 0,15583246 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,14004994 0,16131165 ! embryonic pattern specification GO:0009880 49 27 0,000 0,14004994 0,16123563 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,14004994 0,16115968 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,14004994 0,1610838 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,14004994 0,161008 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,14004994 0,16093227 ! iron ion transport GO:0006826 65 27 0,000 0,14004994 0,16085661 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,14004994 0,16078102 ! superoxide metabolic process GO:0006801 41 27 0,000 0,14004994 0,1607055 ! tube lumen formation GO:0035148 59 27 0,000 0,14004994 0,16063005 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,14004994 0,16055467 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,14004994 0,16047936 ! response to toxin GO:0009636 49 27 0,000 0,14004994 0,16040413 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,14004994 0,16032896 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,14004994 0,16025386 ! leukocyte proliferation GO:0070661 59 27 0,000 0,14004994 0,16017884 GO:0032943|mononuclear cell proliferation, ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,14484398 0,1655844 ! protein amino acid acylation GO:0043543 59 28 0,000 0,14484398 0,16550695 ! circadian rhythm GO:0007623 56 28 0,000 0,14484398 0,16542957 ! dendrite development GO:0016358 67 28 0,000 0,14484398 0,16535227 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,14484398 0,16527504 ! sperm motility GO:0030317 37 28 0,000 0,14484398 0,16519788 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,14484398 0,16512079 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,14484398 0,16504378 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,14484398 0,16496683 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,14484398 0,16488996 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,14484398 0,16481316 ! glutathione metabolic process GO:0006749 42 28 0,000 0,14484398 0,16473643 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,14484398 0,16465977 ! lipid oxidation GO:0034440 48 28 0,000 0,14484398 0,16458319 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,14484398 0,16450667 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,14484398 0,16443023 ! translational initiation GO:0006413 66 29 0,000 0,14961144 0,16976347 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,14961144 0,16968465 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,14961144 0,16960591 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,14961144 0,16952725 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,14961144 0,16944865 ! primary neural tube formation GO:0014020 61 29 0,000 0,14961144 0,16937013 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,14961144 0,16929168 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,14961144 0,16921331 ! somitogenesis GO:0001756 52 29 0,000 0,14961144 0,169135 ! synaptogenesis GO:0007416 46 29 0,000 0,14961144 0,16905677 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,14961144 0,16897861 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,14961144 0,16890053 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,14961144 0,16882251 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,15435245 0,17409189 ! phenol metabolic process GO:0018958 56 30 0,000 0,15435245 0,17401155 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,15435245 0,17393129 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,15435245 0,1738511 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,15435245 0,17377098 ! sensory perception of taste GO:0050909 41 30 0,000 0,15435245 0,17369094 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,15435245 0,17361097 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,15435245 0,17353108 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,15435245 0,17345126 ! myofibril assembly GO:0030239 50 30 0,000 0,15435245 0,17337151 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,15435245 0,17329183 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,15435245 0,17321223 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,15435245 0,1731327 ! cell fate determination GO:0001709 64 30 0,000 0,15435245 0,17305325 ! phospholipid transport GO:0015914 65 30 0,000 0,15435245 0,17297387 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,15435245 0,17289456 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,15435245 0,17281532 GO:0046496|nicotinamide nucleotide metabolic process, ! tissue homeostasis GO:0001894 50 30 0,000 0,15435245 0,17273616 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,15435245 0,17265706 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,15906716 0,17784946 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,15906716 0,1777681 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,15906716 0,17768682 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,15906716 0,17760561 ! regulation of innate immune response GO:0045088 57 31 0,000 0,15906716 0,17752447 ! ovulation cycle process GO:0022602 55 31 0,000 0,15906716 0,17744341 ! male gonad development GO:0008584 56 31 0,000 0,15906716 0,17736242 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,15906716 0,17728151 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,15906716 0,17720067 ! natural killer cell activation GO:0030101 50 31 0,000 0,15906716 0,1771199 ! cofactor catabolic process GO:0051187 54 31 0,000 0,15906716 0,17703921 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,15906716 0,17695859 ! response to heat GO:0009408 54 31 0,000 0,15906716 0,17687805 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,15906716 0,17679757 ! collagen metabolic process GO:0032963 49 32 0,000 0,16375571 0,18192597 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,16375571 0,18184328 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,16375571 0,18176066 ! muscle cell development GO:0055001 52 32 0,000 0,16375571 0,18167811 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,16375571 0,18159565 ! ovulation cycle GO:0042698 57 32 0,000 0,16375571 0,18151325 ! BMP signaling pathway GO:0030509 71 32 0,000 0,16375571 0,18143093 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,16375571 0,18134869 ! gene silencing GO:0016458 71 32 0,000 0,16375571 0,18126652 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,16841826 0,18634321 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,16841826 0,18625886 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,16841826 0,18617458 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,16841826 0,18609037 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,16841826 0,18600624 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,16841826 0,18592219 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,16841826 0,18583822 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,16841826 0,18575432 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,16841826 0,18567049 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,16841826 0,18558674 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,17305494 0,19061011 ! glial cell differentiation GO:0010001 67 34 0,000 0,17305494 0,19052421 ! post-embryonic development GO:0009791 76 34 0,000 0,17305494 0,19043839 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,17305494 0,19035264 ! cholesterol transport GO:0030301 62 34 0,000 0,17305494 0,19026698 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,17305494 0,19018139 ! spliceosome assembly GO:0000245 75 34 0,000 0,17305494 0,19009587 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,17305494 0,19001044 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,17305494 0,18992508 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,17305494 0,18983979 ! adult locomotory behavior GO:0008344 62 34 0,000 0,17305494 0,18975459 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,1776659 0,1947231 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,1776659 0,19463578 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,1776659 0,19454854 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,1776659 0,19446138 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,1776659 0,19437429 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,1776659 0,19428728 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,1776659 0,19420036 ! ceramide metabolic process GO:0006672 72 35 0,000 0,1776659 0,1941135 ! sterol transport GO:0015918 63 35 0,000 0,1776659 0,19402673 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,1776659 0,19394003 ! vesicle localization GO:0051648 70 35 0,000 0,1776659 0,19385341 ! regulation of muscle development GO:0048634 82 36 0,000 0,18225128 0,1987678 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,18225128 0,1986791 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,18225128 0,19859049 ! positive regulation of cell development GO:0010720 85 36 0,000 0,18225128 0,19850195 ! protein targeting to membrane GO:0006612 75 36 0,000 0,18225128 0,19841349 ! regulation of proteolysis GO:0030162 77 36 0,000 0,18225128 0,19832511 ! aerobic respiration GO:0009060 56 36 0,000 0,18225128 0,19823681 ! cytokine production GO:0001816 68 36 0,000 0,18225128 0,19814858 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,18225128 0,19806044 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,18225128 0,19797237 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,18681121 0,20283546 ! female gonad development GO:0008585 71 37 0,000 0,18681121 0,20274536 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,18681121 0,20265533 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,18681121 0,20256538 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,18681121 0,20247551 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,19134585 0,20729841 ! organic anion transport GO:0015711 82 38 0,000 0,19134585 0,20720652 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,19134585 0,20711472 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,19134585 0,20702299 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,19134585 0,20693135 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,19134585 0,20683979 ! spermatid development GO:0007286 69 38 0,000 0,19134585 0,2067483 ! glycogen metabolic process GO:0005977 63 38 0,000 0,19134585 0,2066569 ! pigment metabolic process GO:0042440 87 38 0,000 0,19134585 0,20656558 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,19585533 0,21134036 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,19585533 0,21124705 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,19585533 0,21115383 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,19585533 0,21106068 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,19585533 0,21096762 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,19585533 0,21087465 ! glucan metabolic process GO:0044042 64 39 0,000 0,19585533 0,21078175 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,20033979 0,21551303 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,20033979 0,21541818 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,20033979 0,2153234 GO:0046660|female sex differentiation, ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,20033979 0,21522872 ! RNA export from nucleus GO:0006405 61 41 0,000 0,20479936 0,21992301 ! mRNA catabolic process GO:0006402 79 41 0,000 0,20479936 0,21982638 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,20479936 0,21972984 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,20479936 0,21963338 ! gliogenesis GO:0042063 91 41 0,000 0,20479936 0,21953701 ! feeding behavior GO:0007631 69 41 0,000 0,20479936 0,21944072 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,20479936 0,21934451 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,20479936 0,2192484 ! RNA modification GO:0009451 64 41 0,000 0,20479936 0,21915236 ! organic ether metabolic process GO:0018904 59 42 0,000 0,20923419 0,22379997 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,20923419 0,22370202 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,20923419 0,22360417 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,20923419 0,22350639 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,20923419 0,22340871 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,21364441 0,22801804 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,21364441 0,22791847 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,21364441 0,22781898 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,21364441 0,22771959 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,21364441 0,22762028 ! segmentation GO:0035282 78 43 0,000 0,21364441 0,22752105 ! ion transmembrane transport GO:0034220 79 43 0,000 0,21364441 0,22742191 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,21803016 0,2319894 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,21803016 0,23188841 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,21803016 0,2317875 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,21803016 0,23168668 ! striated muscle contraction GO:0006941 85 44 0,000 0,21803016 0,23158594 ! phagocytosis GO:0006909 105 44 0,000 0,21803016 0,2314853 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,21803016 0,23138474 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,22239157 0,23591081 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,22239157 0,23580842 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,22239157 0,23570612 ! biopolymer methylation GO:0043414 91 45 0,000 0,22239157 0,2356039 ! female gamete generation GO:0007292 71 45 0,000 0,22239157 0,23550178 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,22239157 0,23539974 ! polyol metabolic process GO:0019751 77 45 0,000 0,22239157 0,23529779 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,22672877 0,23978285 ! glycolysis GO:0006096 71 46 0,000 0,22672877 0,2396791 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,22672877 0,23957543 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,22672877 0,23947185 ! cell growth GO:0016049 90 46 0,000 0,22672877 0,23936836 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,23104191 0,24381658 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,23533111 0,24823571 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,23533111 0,24812857 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,23533111 0,24802152 ! methylation GO:0032259 97 48 0,000 0,23533111 0,24791457 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,2395965 0,25229925 ! regulation of ion transport GO:0043269 86 50 0,000 0,24383822 0,25665523 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,24383822 0,25654469 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,24383822 0,25643426 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,24383822 0,25632391 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,24383822 0,25621367 ! viral infectious cycle GO:0019058 104 51 0,000 0,2480564 0,26053387 ! peptide metabolic process GO:0006518 80 51 0,000 0,2480564 0,26042191 ! response to temperature stimulus GO:0009266 84 51 0,000 0,2480564 0,26031005 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,25225117 0,26459837 ! Notch signaling pathway GO:0007219 111 52 0,000 0,25225117 0,26448481 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,25225117 0,26437134 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,25225117 0,26425798 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,25225117 0,26414471 ! excretion GO:0007588 87 52 0,000 0,25225117 0,26403153 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,25225117 0,26391846 ! histone modification GO:0016570 104 52 0,000 0,25225117 0,26380548 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,25225117 0,2636926 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,25225117 0,26357981 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,25642265 0,26782408 ! inner ear development GO:0048839 89 53 0,000 0,25642265 0,26770963 ! vesicle organization GO:0016050 127 53 0,000 0,25642265 0,26759527 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,26057098 0,27180824 ! neuromuscular process GO:0050905 107 54 0,000 0,26057098 0,27169223 ! membrane fusion GO:0006944 122 54 0,000 0,26057098 0,27157632 ! covalent chromatin modification GO:0016569 115 54 0,000 0,26057098 0,27146051 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,26057098 0,2713448 ! regulation of cell shape GO:0008360 142 54 0,000 0,26057098 0,27122919 ! RNA catabolic process GO:0006401 103 55 0,000 0,26469628 0,27540588 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,26469628 0,27528864 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,26469628 0,27517149 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,26879868 0,27931739 ! glucose catabolic process GO:0006007 88 56 0,000 0,26879868 0,27919863 ! RNA elongation GO:0006354 90 56 0,000 0,26879868 0,27907997 ! chloride transport GO:0006821 102 57 0,000 0,27287831 0,28319529 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,27693529 0,28728362 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,27693529 0,28716168 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,27693529 0,28703985 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,27693529 0,28691812 ! nuclear export GO:0051168 110 59 0,000 0,28096975 0,29097461 ! lipid modification GO:0030258 112 60 0,000 0,28498181 0,29500448 ! regulation of endocytosis GO:0030100 104 60 0,000 0,28498181 0,29487953 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,28498181 0,29475468 ! adult behavior GO:0030534 104 60 0,000 0,28498181 0,29462995 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,2889716 0,29862843 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,2889716 0,29850216 ! proton transport GO:0015992 117 61 0,000 0,2889716 0,298376 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,29293923 0,30234497 ! tRNA processing GO:0008033 102 62 0,000 0,29293923 0,30221729 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,29688484 0,30615858 ! hydrogen transport GO:0006818 121 64 0,000 0,30080854 0,31007395 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,30080854 0,30994317 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,30080854 0,30981251 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,30471046 0,31369896 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,30471046 0,31356683 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,30471046 0,3134348 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,30471046 0,31330288 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,3085907 0,31715906 ! gonad development GO:0008406 115 66 0,000 0,3085907 0,31702569 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,3085907 0,31689243 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,31244941 0,32072013 ! secondary metabolic process GO:0019748 125 67 0,000 0,31244941 0,32058543 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,31628668 0,32438638 ! hexose catabolic process GO:0019320 113 68 0,000 0,31628668 0,32425026 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,32010265 0,32802465 ! single fertilization GO:0007338 83 69 0,000 0,32010265 0,32788712 ! cell redox homeostasis GO:0045454 114 70 0,000 0,32389742 0,33163512 ! germ cell development GO:0007281 133 70 0,000 0,32389742 0,33149619 ! activation of immune response GO:0002253 120 70 0,000 0,32389742 0,33135737 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,32389742 0,33121867 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,32767113 0,33493747 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,32767113 0,33479739 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,33142387 0,33849018 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,33142387 0,33834873 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,33515577 0,34201569 ! amino acid transport GO:0006865 148 74 0,000 0,33886695 0,34565844 ! transition metal ion transport GO:0000041 143 75 0,000 0,34255752 0,34927713 ! reproductive structure development GO:0048608 131 75 0,000 0,34255752 0,34913142 ! rhythmic process GO:0048511 142 75 0,000 0,34255752 0,34898583 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,34622758 0,35257774 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,34987727 0,3561459 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,34987727 0,35599757 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,34987727 0,35584936 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,35350668 0,3593911 ! antigen processing and presentation GO:0019882 117 78 0,000 0,35350668 0,3592416 ! fertilization GO:0009566 99 78 0,000 0,35350668 0,35909223 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,35711593 0,36260773 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,35711593 0,36245709 ! muscle cell differentiation GO:0042692 178 81 0,000 0,36427439 0,36956908 ! response to hypoxia GO:0001666 178 81 0,000 0,36427439 0,36941567 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,36427439 0,36926238 ! response to oxygen levels GO:0070482 183 83 0,000 0,37135355 0,37628234 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,37135355 0,37612633 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,37135355 0,37597046 ! digestion GO:0007586 130 84 0,000 0,37486366 0,37936699 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,37835427 0,38274098 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,37835427 0,38258256 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,38527741 0,3894219 ! alcohol catabolic process GO:0046164 142 87 0,000 0,38527741 0,38926084 ! nucleosome assembly GO:0006334 126 87 0,000 0,38527741 0,38909993 ! cellular respiration GO:0045333 143 88 0,000 0,38871017 0,39240452 ! amine biosynthetic process GO:0009309 146 88 0,000 0,38871017 0,39224243 ! sensory perception of smell GO:0007608 117 88 0,000 0,38871017 0,39208048 ! chromatin assembly GO:0031497 128 88 0,000 0,38871017 0,39191867 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,38871017 0,39175699 ! cellular defense response GO:0006968 123 89 0,000 0,39212384 0,39503445 ! regulation of neurological system process GO:0031644 175 89 0,000 0,39212384 0,39487162 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,39551855 0,39812601 ! response to unfolded protein GO:0006986 139 90 0,000 0,39551855 0,39796204 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,40225149 0,40456995 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,40558993 0,40775975 ! amine transport GO:0015837 181 93 0,000 0,40558993 0,40759202 ! vitamin metabolic process GO:0006766 153 93 0,000 0,40558993 0,40742442 ! female pregnancy GO:0007565 166 94 0,000 0,40890981 0,41059049 ! sterol metabolic process GO:0016125 166 94 0,000 0,40890981 0,4104218 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,40890981 0,41025325 ! nucleosome organization GO:0034728 143 95 0,000 0,41221125 0,41339576 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,41221125 0,41322613 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,41221125 0,41305663 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,41221125 0,41288728 ! response to protein stimulus GO:0051789 158 96 0,000 0,41549433 0,41600519 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,41875918 0,41910228 ! positive regulation of immune response GO:0050778 175 100 0,000 0,42844524 0,42862068 ! hormone metabolic process GO:0042445 171 100 0,000 0,42844524 0,42844524