pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6746-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of MAP kinase activity GO:0043406 160 93 9,000 3,137E-13 7,549E-10 ! indolalkylamine metabolic process GO:0006586 17 11 4,000 1,146E-10 1,379E-07 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cellular response to hormone stimulus GO:0032870 167 82 7,000 1,797E-10 1,441E-07 ! indolalkylamine biosynthetic process GO:0046219 7 5 3,000 4,249E-10 2,556E-07 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! nuclear migration GO:0007097 12 6 3,000 1,272E-09 6,12E-07 ! activation of MAPK activity GO:0000187 115 67 6,000 1,591E-09 6,381E-07 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 6,000 1,591E-09 5,469E-07 ! regulation of protein export from nucleus GO:0046825 10 7 3,000 2,961E-09 8,904E-07 ! organ growth GO:0035265 15 7 3,000 2,961E-09 7,915E-07 ! negative regulation of peptide secretion GO:0002792 10 7 3,000 2,961E-09 7,123E-07 GO:0046676|negative regulation of insulin secretion, ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 3,000 2,961E-09 6,476E-07 ! positive regulation of locomotion GO:0040017 39 21 4,000 4,928E-09 9,88E-07 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! induction of apoptosis by intracellular signals GO:0008629 93 45 5,000 5,441E-09 1,007E-06 ! establishment of nucleus localization GO:0040023 16 8 3,000 5,907E-09 1,015E-06 ! regulation of growth hormone secretion GO:0060123 16 8 3,000 5,907E-09 9,475E-07 ! regulation of chemotaxis GO:0050920 40 22 4,000 6,361E-09 9,566E-07 ! negative regulation of transport GO:0051051 153 84 6,000 7,943E-09 1,124E-06 ! regulation of behavior GO:0050795 43 24 4,000 1,022E-08 1,366E-06 ! induction of positive chemotaxis GO:0050930 15 9 3,000 1,061E-08 1,343E-06 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 3,000 1,061E-08 1,276E-06 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 3,000 1,764E-08 2,021E-06 ! hormone metabolic process GO:0042445 157 97 6,000 2,181E-08 2,385E-06 ! positive regulation of cell migration GO:0030335 126 57 5,000 2,353E-08 2,462E-06 ! nucleus localization GO:0051647 19 11 3,000 2,765E-08 2,772E-06 ! DNA damage response, signal transduction GO:0042770 128 60 5,000 3,222E-08 3,101E-06 ! protein amino acid autophosphorylation GO:0046777 141 60 5,000 3,222E-08 2,982E-06 ! regulation of positive chemotaxis GO:0050926 19 12 3,000 4,138E-08 3,687E-06 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of cell motion GO:0051272 146 64 5,000 4,778E-08 4,106E-06 ! negative regulation of protein kinase activity GO:0006469 130 67 5,000 6,313E-08 5,238E-06 ! negative regulation of kinase activity GO:0033673 131 68 5,000 6,907E-08 5,539E-06 ! negative regulation of transferase activity GO:0051348 140 72 5,000 9,762E-08 7,577E-06 ! carbohydrate homeostasis GO:0033500 53 38 4,000 1,166E-07 8,768E-06 GO:0042593|glucose homeostasis, ! regulation of intracellular protein transport GO:0033157 80 42 4,000 1,957E-07 1,427E-05 ! negative regulation of hormone secretion GO:0046888 25 17 3,000 1,966E-07 1,391E-05 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 3,000 1,966E-07 1,352E-05 ! positive regulation of response to external stimulus GO:0032103 77 43 4,000 2,209E-07 1,477E-05 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 2,000 2,838E-07 1,845E-05 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 4,000 3,123E-07 1,978E-05 ! positive regulation of hormone secretion GO:0046887 32 19 3,000 3,187E-07 1,966E-05 ! positive regulation of pseudopodium assembly GO:0031274 14 6 2,000 5,663E-07 3,406E-05 GO:0031272|regulation of pseudopodium assembly, ! regulation of multicellular organism growth GO:0040014 85 55 4,000 7,755E-07 4,551E-05 ! negative regulation of phosphorylation GO:0042326 47 24 3,000 8,634E-07 4,946E-05 ! regulation of intracellular transport GO:0032386 101 57 4,000 9,288E-07 5,197E-05 ! regulation of lipid kinase activity GO:0043550 13 7 2,000 9,888E-07 5,407E-05 ! macrophage differentiation GO:0030225 11 7 2,000 9,888E-07 5,287E-05 ! regulation of insulin secretion GO:0050796 37 25 3,000 1,025E-06 5,364E-05 ! insulin receptor signaling pathway GO:0008286 64 26 3,000 1,209E-06 6,189E-05 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 3,000 1,209E-06 6,06E-05 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 3,000 1,209E-06 5,937E-05 GO:0045936|negative regulation of phosphate metabolic process, ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 3,000 1,416E-06 6,813E-05 ! positive regulation of endothelial cell migration GO:0010595 19 8 2,000 1,578E-06 7,447E-05 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 1,578E-06 7,303E-05 ! peptidyl-tyrosine modification GO:0018212 50 28 3,000 1,648E-06 7,481E-05 ! regulation of peptide secretion GO:0002791 47 29 3,000 1,907E-06 8,498E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 2,000 2,362E-06 1,033E-04 ! triglyceride metabolic process GO:0006641 43 31 3,000 2,515E-06 1,08E-04 ! DNA damage checkpoint GO:0000077 71 33 3,000 3,255E-06 1,374E-04 ! biogenic amine biosynthetic process GO:0042401 62 34 3,000 3,68E-06 1,527E-04 ! negative regulation of secretion GO:0051048 63 35 3,000 4,145E-06 1,69E-04 ! neutral lipid metabolic process GO:0006638 50 35 3,000 4,145E-06 1,662E-04 GO:0006639|acylglycerol metabolic process, ! positive regulation of endothelial cell proliferation GO:0001938 22 11 2,000 4,62E-06 1,822E-04 ! chondrocyte differentiation GO:0002062 24 11 2,000 4,62E-06 1,793E-04 ! negative regulation of glucose import GO:0046325 17 11 2,000 4,62E-06 1,764E-04 GO:0010829|negative regulation of glucose transport, ! DNA integrity checkpoint GO:0031570 75 36 3,000 4,652E-06 1,749E-04 ! hormone biosynthetic process GO:0042446 57 36 3,000 4,652E-06 1,722E-04 ! positive regulation of phosphorylation GO:0042327 129 79 4,000 4,739E-06 1,728E-04 ! glycerol ether metabolic process GO:0006662 53 37 3,000 5,204E-06 1,869E-04 ! cellular response to insulin stimulus GO:0032869 82 37 3,000 5,204E-06 1,841E-04 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 4,000 5,361E-06 1,87E-04 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of cell projection assembly GO:0060491 30 12 2,000 6,146E-06 2,112E-04 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 2,000 6,146E-06 2,083E-04 ! organic ether metabolic process GO:0018904 55 39 3,000 6,451E-06 2,156E-04 ! regulation of hormone secretion GO:0046883 62 40 3,000 7,15E-06 2,357E-04 ! regulation of protein transport GO:0051223 154 87 4,000 7,62E-06 2,478E-04 GO:0070201|regulation of establishment of protein localization, ! hormone-mediated signaling GO:0009755 74 41 3,000 7,905E-06 2,536E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 2,000 1,012E-05 3,205E-04 ! biogenic amine metabolic process GO:0006576 155 94 4,000 1,113E-05 3,477E-04 ! response to insulin stimulus GO:0032868 95 46 3,000 1,259E-05 3,883E-04 ! negative regulation of bone remodeling GO:0046851 33 15 2,000 1,263E-05 3,845E-04 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 1,263E-05 3,797E-04 ! regulation of protein localization GO:0032880 176 97 4,000 1,297E-05 3,853E-04 ! regulation of inflammatory response GO:0050727 75 48 3,000 1,494E-05 4,383E-04 ! filopodium assembly GO:0046847 32 16 2,000 1,55E-05 4,494E-04 ! negative regulation of tissue remodeling GO:0034104 36 16 2,000 1,55E-05 4,441E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 2,000 1,878E-05 5,317E-04 ! negative regulation of protein catabolic process GO:0042177 40 17 2,000 1,878E-05 5,255E-04 ! neutrophil chemotaxis GO:0030593 27 17 2,000 1,878E-05 5,195E-04 ! microspike assembly GO:0030035 36 17 2,000 1,878E-05 5,136E-04 ! positive regulation of growth GO:0045927 90 52 3,000 2,059E-05 5,566E-04 ! cartilage development GO:0051216 90 52 3,000 2,059E-05 5,504E-04 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 3,000 2,394E-05 6,329E-04 ! regulation of endothelial cell migration GO:0010594 44 19 2,000 2,665E-05 6,969E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 3,000 2,969E-05 7,681E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 2,000 3,128E-05 8,006E-04 ! regulation of glucose import GO:0046324 29 20 2,000 3,128E-05 7,922E-04 GO:0010827|regulation of glucose transport, ! positive regulation of secretion GO:0051047 95 59 3,000 3,405E-05 8,533E-04 ! establishment of organelle localization GO:0051656 109 59 3,000 3,405E-05 8,445E-04 ! negative regulation of response to stimulus GO:0048585 100 60 3,000 3,639E-05 8,935E-04 ! inactivation of MAPK activity GO:0000188 39 21 2,000 3,641E-05 8,849E-04 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 3,641E-05 8,761E-04 ! response to peptide hormone stimulus GO:0043434 122 61 3,000 3,886E-05 9,256E-04 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 4,207E-05 9,923E-04 ! regulation of lipid metabolic process GO:0019216 115 63 3,000 4,414E-05 1,031E-03 ! multicellular organism reproduction GO:0032504 111 64 3,000 4,698E-05 1,087E-03 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of DNA replication GO:0045740 43 23 2,000 4,827E-05 1,106E-03 ! myeloid leukocyte differentiation GO:0002573 40 23 2,000 4,827E-05 1,096E-03 ! negative regulation of catabolic process GO:0009895 50 23 2,000 4,827E-05 1,085E-03 ! cell projection assembly GO:0030031 120 66 3,000 5,303E-05 1,181E-03 ! positive regulation of fibroblast proliferation GO:0048146 43 24 2,000 5,504E-05 1,215E-03 ! regulation of oxidoreductase activity GO:0051341 46 24 2,000 5,504E-05 1,204E-03 ! cellular hormone metabolic process GO:0034754 113 67 3,000 5,627E-05 1,22E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 2,000 6,241E-05 1,341E-03 ! interaction with host GO:0051701 62 25 2,000 6,241E-05 1,329E-03 ! cell cycle checkpoint GO:0000075 137 69 3,000 6,317E-05 1,333E-03 ! regulation of endothelial cell proliferation GO:0001936 57 26 2,000 7,039E-05 1,473E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 3,000 7,464E-05 1,548E-03 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 7,901E-05 1,625E-03 ! positive regulation of cell projection organization GO:0031346 58 27 2,000 7,901E-05 1,611E-03 ! organelle localization GO:0051640 136 74 3,000 8,309E-05 1,68E-03 ! rhythmic process GO:0048511 128 75 3,000 8,756E-05 1,756E-03 ! negative regulation of protein modification process GO:0031400 60 28 2,000 8,83E-05 1,756E-03 ! regulation of catabolic process GO:0009894 161 76 3,000 9,221E-05 1,819E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 9,376E-05 1,834E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 9,376E-05 1,819E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 9,376E-05 1,805E-03 ! valine metabolic process GO:0006573 10 5 1,000 9,376E-05 1,79E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 9,376E-05 1,776E-03 ! regulation of sensory perception GO:0051931 7 5 1,000 9,376E-05 1,762E-03 GO:0051930|regulation of sensory perception of pain, ! negative regulation of protein complex assembly GO:0031333 59 29 2,000 9,826E-05 1,833E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 1,325E-04 2,452E-03 ! sleep GO:0030431 13 6 1,000 1,404E-04 2,578E-03 ! negative regulation of platelet activation GO:0010544 9 6 1,000 1,404E-04 2,558E-03 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 1,000 1,404E-04 2,539E-03 ! leukocyte chemotaxis GO:0030595 50 33 2,000 1,454E-04 2,611E-03 GO:0060326|cell chemotaxis, ! amine biosynthetic process GO:0009309 138 86 3,000 1,491E-04 2,657E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 2,000 1,591E-04 2,815E-03 ! positive regulation of protein modification process GO:0031401 136 88 3,000 1,629E-04 2,861E-03 ! ossification GO:0001503 188 90 3,000 1,777E-04 3,098E-03 ! bone development GO:0060348 189 91 3,000 1,854E-04 3,21E-03 ! negative regulation of cell activation GO:0050866 65 36 2,000 1,89E-04 3,249E-03 ! regulation of defense response GO:0031347 149 92 3,000 1,934E-04 3,3E-03 ! mRNA stabilization GO:0048255 18 7 1,000 1,961E-04 3,323E-03 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 10 7 1,000 1,961E-04 3,3E-03 ! regulation of respiratory burst GO:0060263 11 7 1,000 1,961E-04 3,277E-03 ! negative regulation of multicellular organismal process GO:0051241 166 93 3,000 2,016E-04 3,345E-03 ! establishment or maintenance of cell polarity GO:0007163 83 37 2,000 2,052E-04 3,382E-03 ! interphase of mitotic cell cycle GO:0051329 209 95 3,000 2,188E-04 3,581E-03 ! positive regulation of DNA metabolic process GO:0051054 72 38 2,000 2,223E-04 3,615E-03 ! interphase GO:0051325 213 98 3,000 2,465E-04 3,981E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 2,61E-04 4,186E-03 ! succinate metabolic process GO:0006105 14 8 1,000 2,61E-04 4,158E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 2,61E-04 4,131E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,61E-04 4,104E-03 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 1,000 2,61E-04 4,077E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 2,61E-04 4,051E-03 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 3,216E-04 4,961E-03 ! regulation of developmental growth GO:0048638 15 9 1,000 3,348E-04 5,131E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 3,348E-04 5,099E-03 ! regulation of glycolysis GO:0006110 21 9 1,000 3,348E-04 5,067E-03 ! keratinocyte proliferation GO:0043616 14 9 1,000 3,348E-04 5,035E-03 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 1,000 3,348E-04 5,004E-03 ! phosphagen metabolic process GO:0006599 12 9 1,000 3,348E-04 4,973E-03 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 16 9 1,000 3,348E-04 4,942E-03 ! protein heterooligomerization GO:0051291 16 9 1,000 3,348E-04 4,912E-03 ! response to amine stimulus GO:0014075 13 9 1,000 3,348E-04 4,883E-03 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! S phase GO:0051320 9 9 1,000 3,348E-04 4,853E-03 GO:0000084|S phase of mitotic cell cycle, ! leukocyte migration GO:0050900 68 45 2,000 3,682E-04 5,305E-03 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 2,000 3,93E-04 5,628E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 1,000 4,177E-04 5,947E-03 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 1,000 4,177E-04 5,912E-03 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 4,177E-04 5,877E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 4,177E-04 5,843E-03 ! lung alveolus development GO:0048286 26 10 1,000 4,177E-04 5,809E-03 ! V(D)J recombination GO:0033151 28 10 1,000 4,177E-04 5,776E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 4,177E-04 5,743E-03 ! positive regulation of phagocytosis GO:0050766 13 10 1,000 4,177E-04 5,71E-03 ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 4,177E-04 5,678E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 4,177E-04 5,646E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 4,177E-04 5,615E-03 ! localization within membrane GO:0051668 20 10 1,000 4,177E-04 5,583E-03 ! positive regulation of defense response GO:0031349 76 47 2,000 4,189E-04 5,568E-03 ! regulation of mast cell proliferation GO:0070666 81 48 2,000 4,458E-04 5,893E-03 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 4,738E-04 6,229E-03 ! regulation of cell projection organization GO:0031344 121 50 2,000 5,029E-04 6,576E-03 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 5,095E-04 6,626E-03 ! blood vessel remodeling GO:0001974 29 11 1,000 5,095E-04 6,591E-03 ! negative regulation of proteolysis GO:0045861 25 11 1,000 5,095E-04 6,555E-03 ! substrate-bound cell migration GO:0006929 13 11 1,000 5,095E-04 6,521E-03 ! negative regulation of ossification GO:0030279 26 11 1,000 5,095E-04 6,486E-03 ! regulation of leukocyte migration GO:0002685 26 11 1,000 5,095E-04 6,452E-03 ! regulation of embryonic development GO:0045995 27 11 1,000 5,095E-04 6,418E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 2,000 5,332E-04 6,681E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of muscle contraction GO:0006937 81 52 2,000 5,645E-04 7,038E-03 ! response to UV GO:0009411 104 53 2,000 5,971E-04 7,405E-03 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 1,000 6,102E-04 7,529E-03 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 6,102E-04 7,49E-03 ! virus-host interaction GO:0019048 29 12 1,000 6,102E-04 7,452E-03 ! regulation of B cell proliferation GO:0030888 20 12 1,000 6,102E-04 7,415E-03 ! cartilage condensation GO:0001502 20 12 1,000 6,102E-04 7,377E-03 ! positive regulation of cell growth GO:0030307 22 12 1,000 6,102E-04 7,34E-03 ! entry into host cell GO:0030260 32 12 1,000 6,102E-04 7,304E-03 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of phagocytosis GO:0050764 16 12 1,000 6,102E-04 7,268E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 1,000 6,102E-04 7,232E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of protein catabolic process GO:0042176 116 55 2,000 6,657E-04 7,851E-03 ! regulation of DNA replication GO:0006275 101 56 2,000 7,018E-04 8,237E-03 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 7,197E-04 8,405E-03 ! negative regulation of lipid metabolic process GO:0045833 19 13 1,000 7,197E-04 8,365E-03 ! cellular carbohydrate catabolic process GO:0044275 15 13 1,000 7,197E-04 8,325E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 7,197E-04 8,285E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 33 13 1,000 7,197E-04 8,245E-03 ! regulation of mRNA stability GO:0043488 31 13 1,000 7,197E-04 8,206E-03 ! cytoplasmic sequestering of protein GO:0051220 24 13 1,000 7,197E-04 8,168E-03 ! regulation of bone remodeling GO:0046850 137 57 2,000 7,392E-04 8,349E-03 ! lipid modification GO:0030258 97 57 2,000 7,392E-04 8,31E-03 ! regulation of tissue remodeling GO:0034103 140 58 2,000 7,778E-04 8,704E-03 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 8,379E-04 9,334E-03 ! negative regulation of caspase activity GO:0043154 22 14 1,000 8,379E-04 9,291E-03 ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 8,379E-04 9,248E-03 ! regulation of RNA stability GO:0043487 32 14 1,000 8,379E-04 9,206E-03 ! release of cytochrome c from mitochondria GO:0001836 30 14 1,000 8,379E-04 9,164E-03 ! regulation of heart contraction GO:0008016 110 60 2,000 8,587E-04 9,349E-03 ! regulation of protein complex assembly GO:0043254 117 61 2,000 9,011E-04 9,766E-03 ! viral reproductive process GO:0022415 126 62 2,000 9,448E-04 0,01019395 ! positive regulation of cell size GO:0045793 27 15 1,000 9,649E-04 0,01036404 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 1,000 9,649E-04 0,01031798 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 9,649E-04 0,01027233 ! dopamine metabolic process GO:0042417 35 15 1,000 9,649E-04 0,01022707 ! myeloid cell differentiation GO:0030099 111 65 2,000 1,084E-03 0,01143858 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 1,101E-03 0,01156274 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 1,101E-03 0,01151246 ! startle response GO:0001964 28 16 1,000 1,101E-03 0,01146263 ! negative regulation of leukocyte proliferation GO:0070664 31 16 1,000 1,101E-03 0,01141322 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! viral reproduction GO:0016032 134 68 2,000 1,235E-03 0,01275688 ! negative regulation of peptidase activity GO:0010466 27 17 1,000 1,245E-03 0,01279867 ! negative regulation of blood coagulation GO:0030195 24 17 1,000 1,245E-03 0,01274421 ! branched chain family amino acid metabolic process GO:0009081 33 17 1,000 1,245E-03 0,01269021 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 1,245E-03 0,01263666 ! regulation of lipid biosynthetic process GO:0046890 25 18 1,000 1,398E-03 0,01412809 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 1,398E-03 0,01406898 ! protein amino acid ADP-ribosylation GO:0006471 33 18 1,000 1,398E-03 0,01401036 ! memory GO:0007613 31 18 1,000 1,398E-03 0,01395223 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 1,398E-03 0,01389457 ! B cell activation GO:0042113 160 71 2,000 1,4E-03 0,0138571 ! skin development GO:0043588 36 19 1,000 1,559E-03 0,01537102 ! lipid phosphorylation GO:0046834 35 19 1,000 1,559E-03 0,01530829 ! regulation of postsynaptic membrane potential GO:0060078 32 19 1,000 1,559E-03 0,01524606 ! mitotic chromosome condensation GO:0007076 34 19 1,000 1,559E-03 0,01518433 ! neuromuscular junction development GO:0007528 34 19 1,000 1,559E-03 0,0151231 ! prostaglandin metabolic process GO:0006693 37 19 1,000 1,559E-03 0,01506237 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 36 19 1,000 1,559E-03 0,01500212 ! apoptotic mitochondrial changes GO:0008637 41 20 1,000 1,729E-03 0,0165693 ! fatty acid beta-oxidation GO:0006635 34 20 1,000 1,729E-03 0,01650354 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 1,729E-03 0,01643831 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of T cell activation GO:0050868 40 20 1,000 1,729E-03 0,0163736 ! negative regulation of coagulation GO:0050819 29 20 1,000 1,729E-03 0,01630939 ! reciprocal meiotic recombination GO:0007131 39 21 1,000 1,907E-03 0,01791972 ! axis specification GO:0009798 38 21 1,000 1,907E-03 0,01785 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 1,000 1,907E-03 0,01778081 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 1,907E-03 0,01771216 ! response to hypoxia GO:0001666 171 81 2,000 2,043E-03 0,01890802 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 1,000 2,093E-03 0,0192953 ! glutamate signaling pathway GO:0007215 41 22 1,000 2,093E-03 0,01922165 ! calcium-independent cell-cell adhesion GO:0016338 30 22 1,000 2,093E-03 0,01914857 ! positive regulation of B cell activation GO:0050871 38 22 1,000 2,093E-03 0,01907603 ! activation of JUN kinase activity GO:0007257 42 22 1,000 2,093E-03 0,01900405 ! response to oxygen levels GO:0070482 176 83 2,000 2,191E-03 0,01981449 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 1,000 2,288E-03 0,02061662 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 2,288E-03 0,0205397 ! visual behavior GO:0007632 42 23 1,000 2,288E-03 0,02046334 ! response to ethanol GO:0045471 46 23 1,000 2,288E-03 0,02038755 ! sex determination GO:0007530 47 23 1,000 2,288E-03 0,02031232 ! regulation of bone mineralization GO:0030500 49 23 1,000 2,288E-03 0,02023764 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 1,000 2,491E-03 0,02195246 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 52 24 1,000 2,491E-03 0,02187234 ! membrane depolarization GO:0051899 39 24 1,000 2,491E-03 0,0217928 ! protein tetramerization GO:0051262 52 24 1,000 2,491E-03 0,02171384 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 1,000 2,702E-03 0,02346966 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 1,000 2,702E-03 0,02338524 ! myelination GO:0042552 45 25 1,000 2,702E-03 0,02330142 ! dicarboxylic acid metabolic process GO:0043648 42 25 1,000 2,702E-03 0,0232182 ! vasculogenesis GO:0001570 46 25 1,000 2,702E-03 0,02313558 ! chromosome condensation GO:0030261 45 25 1,000 2,702E-03 0,02305353 ! regulation of biomineral formation GO:0070167 51 25 1,000 2,702E-03 0,02297207 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 2,702E-03 0,02289119 ! regulation of blood coagulation GO:0030193 40 25 1,000 2,702E-03 0,02281087 ! initiation of viral infection GO:0019059 57 26 1,000 2,921E-03 0,02457602 ! regulation of transcription factor import into nucleus GO:0042990 54 26 1,000 2,921E-03 0,02449039 ! somatic diversification of immune receptors GO:0002200 56 26 1,000 2,921E-03 0,02440535 ! positive regulation of JUN kinase activity GO:0043507 51 26 1,000 2,921E-03 0,02432091 ! regulation of membrane potential GO:0042391 164 93 2,000 3,026E-03 0,02510505 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 3,149E-03 0,02603379 ! negative regulation of lymphocyte activation GO:0051250 53 27 1,000 3,149E-03 0,02594463 ! leukocyte differentiation GO:0002521 202 96 2,000 3,31E-03 0,02717767 ! lipid oxidation GO:0034440 43 28 1,000 3,384E-03 0,02769472 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 58 28 1,000 3,384E-03 0,02760084 ! regulation of DNA metabolic process GO:0051052 178 97 2,000 3,408E-03 0,02769931 ! catechol metabolic process GO:0009712 54 29 1,000 3,628E-03 0,02938675 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! cellular response to extracellular stimulus GO:0031668 48 29 1,000 3,628E-03 0,02928814 ! regulation of coagulation GO:0050818 46 29 1,000 3,628E-03 0,02919018 ! phenol metabolic process GO:0018958 55 30 1,000 3,879E-03 0,03110854 ! acute-phase response GO:0006953 49 30 1,000 3,879E-03 0,03100519 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 3,879E-03 0,03090252 ! ensheathment of neurons GO:0007272 57 30 1,000 3,879E-03 0,03080053 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 56 30 1,000 3,879E-03 0,03069922 ! regulation of B cell activation GO:0050864 50 30 1,000 3,879E-03 0,03059856 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 1,000 4,138E-03 0,03253666 ! fatty acid catabolic process GO:0009062 48 31 1,000 4,138E-03 0,03243068 ! regulation of protein import into nucleus GO:0042306 63 32 1,000 4,405E-03 0,03441141 ! peripheral nervous system development GO:0007422 64 32 1,000 4,405E-03 0,03430005 ! positive regulation of catabolic process GO:0009896 64 32 1,000 4,405E-03 0,0341894 ! negative regulation of protein transport GO:0051224 69 33 1,000 4,68E-03 0,03620557 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 1,000 4,962E-03 0,03826842 ! positive regulation of endocytosis GO:0045807 50 34 1,000 4,962E-03 0,03814616 ! mismatch repair GO:0006298 46 34 1,000 4,962E-03 0,03802467 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 5,253E-03 0,04012078 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 5,253E-03 0,03999381 ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 5,253E-03 0,03986765 ! calcium-mediated signaling GO:0019722 62 35 1,000 5,253E-03 0,03974228 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 5,551E-03 0,04186428 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 1,000 5,551E-03 0,04173346 ! maintenance of protein location in cell GO:0032507 86 36 1,000 5,551E-03 0,04160345 ! regulation of proteolysis GO:0030162 72 36 1,000 5,551E-03 0,04147424 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 1,000 5,551E-03 0,04134584 ! meiosis I GO:0007127 65 37 1,000 5,856E-03 0,04348646 ! sister chromatid segregation GO:0000819 58 37 1,000 5,856E-03 0,04335266 ! tissue remodeling GO:0048771 76 37 1,000 5,856E-03 0,04321968 ! negative regulation of DNA binding GO:0043392 68 37 1,000 5,856E-03 0,04308751 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 6,169E-03 0,04525199 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 86 39 1,000 6,489E-03 0,04745806 ! learning GO:0007612 77 39 1,000 6,489E-03 0,04731424 ! regulation of action potential in neuron GO:0019228 73 39 1,000 6,489E-03 0,0471713 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 1,000 6,817E-03 0,04940556 ! negative regulation of binding GO:0051100 72 40 1,000 6,817E-03 0,0492572 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 6,817E-03 0,04910972 ! maintenance of protein location GO:0045185 91 40 1,000 6,817E-03 0,04896312 ! cellular amide metabolic process GO:0043603 67 41 1,000 7,153E-03 0,05121837 ! regulation of T cell proliferation GO:0042129 71 41 1,000 7,153E-03 0,05106639 ! keratinocyte differentiation GO:0030216 62 41 1,000 7,153E-03 0,05091531 ! regulation of T cell differentiation GO:0045580 70 41 1,000 7,153E-03 0,05076511 ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 7,153E-03 0,0506158 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 1,000 7,845E-03 0,05535399 ! JAK-STAT cascade GO:0007259 71 44 1,000 8,202E-03 0,05770496 ! maintenance of location in cell GO:0051651 97 44 1,000 8,202E-03 0,05753672 ! regulation of JAK-STAT cascade GO:0046425 70 45 1,000 8,567E-03 0,05991803 ! icosanoid metabolic process GO:0006690 80 45 1,000 8,567E-03 0,05974436 ! cell growth GO:0016049 84 45 1,000 8,567E-03 0,05957169 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 8,938E-03 0,06197615 ! negative regulation of cell migration GO:0030336 115 46 1,000 8,938E-03 0,06179806 ! epidermal cell differentiation GO:0009913 68 46 1,000 8,938E-03 0,06162098 ! vascular process in circulatory system GO:0003018 80 47 1,000 9,317E-03 0,06404784 ! JNK cascade GO:0007254 91 47 1,000 9,317E-03 0,06386536 ! regulation of JNK cascade GO:0046328 94 47 1,000 9,317E-03 0,06368393 ! regulation of lymphocyte differentiation GO:0045619 81 48 1,000 9,703E-03 0,06613244 ! positive regulation of cell cycle GO:0045787 89 48 1,000 9,703E-03 0,06594562 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 1,000 9,703E-03 0,06575986 ! regulation of action potential GO:0001508 95 49 1,000 0,01009544 0,06822931 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 1,000 0,01009544 0,06803819 ! peptide metabolic process GO:0006518 76 49 1,000 0,01009544 0,06784814 ! unsaturated fatty acid metabolic process GO:0033559 86 49 1,000 0,01009544 0,06765915 ! neuromuscular process GO:0050905 99 50 1,000 0,01049513 0,07014246 ! regulation of ossification GO:0030278 117 50 1,000 0,01049513 0,06994816 ! negative regulation of immune system process GO:0002683 95 50 1,000 0,01049513 0,06975493 ! viral infectious cycle GO:0019058 99 51 1,000 0,01090174 0,07225782 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 1,000 0,01090174 0,07205931 ! regulation of cell shape GO:0008360 125 51 1,000 0,01090174 0,07186189 ! regulation of angiogenesis GO:0045765 114 52 1,000 0,01131523 0,07438372 ! amino acid activation GO:0043038 92 52 1,000 0,01131523 0,07418104 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! synapse organization GO:0050808 85 52 1,000 0,01131523 0,07397946 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,01216265 0,07930446 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,0125965 0,0819113 ! heart morphogenesis GO:0003007 97 55 1,000 0,0125965 0,08169051 ! negative regulation of cell motion GO:0051271 134 55 1,000 0,0125965 0,08147091 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,01303704 0,08409418 ! muscle fiber development GO:0048747 112 57 1,000 0,01348424 0,0867462 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,01348424 0,08651488 ! maintenance of location GO:0051235 118 57 1,000 0,01348424 0,08628479 ! regulation of endocytosis GO:0030100 91 58 1,000 0,01393804 0,08895207 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,01393804 0,08871675 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,01439841 0,09140521 ! integrin-mediated signaling pathway GO:0007229 135 59 1,000 0,01439841 0,09116467 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,01534574 0,09690772 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,01534574 0,09665404 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01534574 0,09640168 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,01534574 0,09615063 ! neuron fate determination GO:0048664 7 5 0,000 0,01534574 0,09590089 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01534574 0,09565244 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,01534574 0,09540528 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,01534574 0,09515939 ! polyol transport GO:0015791 12 5 0,000 0,01534574 0,09491476 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,01534574 0,09467139 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01534574 0,09442927 ! response to superoxide GO:0000303 10 5 0,000 0,01534574 0,09418837 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,01534574 0,09394871 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,01534574 0,09371026 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01534574 0,09347302 ! female meiosis GO:0007143 7 5 0,000 0,01534574 0,09323698 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01534574 0,09300212 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01534574 0,09276845 ! cobalt ion transport GO:0006824 11 5 0,000 0,01534574 0,09253595 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,01534574 0,09230461 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,01534574 0,09207442 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,01534574 0,09184538 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01534574 0,09161748 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01534574 0,0913907 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,01534574 0,09116504 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,01534574 0,0909405 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01534574 0,09071706 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,01534574 0,09049471 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,01534574 0,09027345 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01534574 0,09005328 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01534574 0,08983417 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 0,000 0,01534574 0,08961612 ! negative chemotaxis GO:0050919 14 5 0,000 0,01534574 0,08939914 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01534574 0,0891832 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01534574 0,0889683 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,01534574 0,08875443 ! behavioral response to pain GO:0048266 9 5 0,000 0,01534574 0,08854159 ! clathrin coat assembly GO:0048268 14 5 0,000 0,01534574 0,08832977 ! Notch receptor processing GO:0007220 8 5 0,000 0,01534574 0,08811896 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01534574 0,08790915 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01534574 0,08770034 ! micturition GO:0060073 9 5 0,000 0,01534574 0,08749252 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01534574 0,08728568 ! copulation GO:0007620 9 5 0,000 0,01534574 0,08707982 ! glial cell fate commitment GO:0021781 13 5 0,000 0,01534574 0,08687492 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,01534574 0,08667099 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01534574 0,08646802 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01534574 0,08626599 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01534574 0,0860649 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,01534574 0,08586475 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01534574 0,08566553 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01534574 0,08546723 ! grooming behavior GO:0007625 6 5 0,000 0,01534574 0,08526985 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01534574 0,08507337 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,01534574 0,0848778 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01534574 0,08468313 ! response to protozoan GO:0001562 10 5 0,000 0,01534574 0,08448934 ! lymph vessel development GO:0001945 10 5 0,000 0,01534574 0,08429644 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,01534574 0,08410443 ! endochondral ossification GO:0001958 16 5 0,000 0,01534574 0,08391328 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01534574 0,083723 ! parathyroid gland development GO:0060017 13 5 0,000 0,01534574 0,08353358 ! anagen GO:0042640 6 5 0,000 0,01534574 0,08334502 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01534574 0,0831573 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01534574 0,08297043 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,01534574 0,0827844 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,01534574 0,0825992 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,01534574 0,08241483 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,01534574 0,08223128 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,01534574 0,08204854 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,01534574 0,08186661 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,01534574 0,08168549 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01534574 0,08150517 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01534574 0,08132565 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01534574 0,08114691 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,01534574 0,08096895 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,01534574 0,08079178 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01534574 0,08061538 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,01534574 0,08043974 ! negative regulation of survival gene product expression GO:0008634 8 5 0,000 0,01534574 0,08026488 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01534574 0,08009077 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01534574 0,07991741 ! histidine catabolic process GO:0006548 6 5 0,000 0,01534574 0,0797448 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01534574 0,07957294 ! microvillus organization GO:0032528 7 5 0,000 0,01534574 0,07940181 GO:0030033|microvillus assembly, ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,01534574 0,07923142 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01534574 0,07906176 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,01534574 0,07889283 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,01534574 0,07872461 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01534574 0,07855711 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,01534574 0,07839032 ! polyol catabolic process GO:0046174 7 5 0,000 0,01534574 0,07822424 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01534574 0,07805886 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01534574 0,07789418 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01534574 0,0777302 ! muscle cell migration GO:0014812 8 5 0,000 0,01534574 0,0775669 ! mitochondrial fission GO:0000266 8 5 0,000 0,01534574 0,07740428 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,01534574 0,07724235 ! mRNA transcription GO:0009299 9 5 0,000 0,01534574 0,07708109 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,01534574 0,07692051 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,01534574 0,07676059 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,01534574 0,07660133 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01534574 0,07644274 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01534574 0,0762848 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01534574 0,07612751 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01534574 0,07597087 ! response to food GO:0032094 6 5 0,000 0,01534574 0,07581487 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01534574 0,07565951 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01534574 0,07550479 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,01534574 0,0753507 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01534574 0,07519724 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,01534574 0,0750444 ! forebrain neuron development GO:0021884 13 5 0,000 0,01534574 0,07489218 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01534574 0,07474057 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,01534574 0,07458958 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01534574 0,0744392 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01534574 0,07428942 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01534574 0,07414025 ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,01534574 0,07399167 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01534574 0,07384369 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,01534574 0,07369629 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,01534574 0,07354949 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01534574 0,07340327 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,01534574 0,07325762 ! basic amino acid transport GO:0015802 11 5 0,000 0,01534574 0,07311256 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,01534574 0,07296807 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,01534574 0,07282415 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01534574 0,07268079 ! depyrimidination GO:0045008 10 5 0,000 0,01534574 0,072538 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01534574 0,07239577 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01534574 0,0722541 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01534574 0,07211297 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,01534574 0,0719724 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,01534574 0,07183238 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,01534574 0,0716929 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01534574 0,07155396 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01534574 0,07141556 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01534574 0,07127769 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,01534574 0,07114035 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,01534574 0,07100354 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01534574 0,07086726 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01534574 0,0707315 ! response to arsenic GO:0046685 10 5 0,000 0,01534574 0,07059626 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,01534574 0,07046153 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01534574 0,07032732 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,01534574 0,07019362 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,01534574 0,07006042 ! response to cadmium ion GO:0046686 7 5 0,000 0,01534574 0,06992773 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,01534574 0,06979554 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,01534574 0,06966385 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01534574 0,06953266 ! decidualization GO:0046697 11 5 0,000 0,01534574 0,06940196 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,01534574 0,06927175 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,01534574 0,06914203 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01534574 0,06901279 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01534574 0,06888404 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,01534574 0,06875576 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01534574 0,06862796 ! neural tube patterning GO:0021532 7 5 0,000 0,01534574 0,06850064 ! embryonic cleavage GO:0040016 6 5 0,000 0,01534574 0,06837378 ! peroxisome fission GO:0016559 5 5 0,000 0,01534574 0,0682474 ! histone demethylation GO:0016577 10 5 0,000 0,01534574 0,06812148 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,01534574 0,06799603 ! mitotic recombination GO:0006312 9 5 0,000 0,01534574 0,06787103 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01534574 0,0677465 ! metaphase plate congression GO:0051310 7 5 0,000 0,01534574 0,06762242 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01534574 0,0674988 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01534574 0,06737563 ! enteric nervous system development GO:0048484 8 5 0,000 0,01534574 0,0672529 ! lymphocyte costimulation GO:0031294 6 5 0,000 0,01534574 0,06713062 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,01534574 0,06700879 ! muscle cell proliferation GO:0033002 11 5 0,000 0,01534574 0,0668874 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01534574 0,06676644 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,01534574 0,06664593 ! plasminogen activation GO:0031639 5 5 0,000 0,01534574 0,06652584 ! B cell homeostasis GO:0001782 13 5 0,000 0,01534574 0,06640619 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,01534574 0,06628697 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01534574 0,06616818 ! metaphase GO:0051323 8 5 0,000 0,01534574 0,06604981 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,01534574 0,06593186 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01534574 0,06581434 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01534574 0,06569723 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01534574 0,06558054 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01534574 0,06546426 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01534574 0,06534839 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,01534574 0,06523294 ! response to redox state GO:0051775 5 5 0,000 0,01534574 0,06511789 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,01534574 0,06500324 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,01534574 0,064889 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01534574 0,06477516 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,01534574 0,06466172 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01534574 0,06454868 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,01534574 0,06443603 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01534574 0,06432377 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,01534574 0,0642119 ! striatum development GO:0021756 9 5 0,000 0,01534574 0,06410042 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,01534574 0,06398933 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,01534574 0,06387862 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01534574 0,0637683 ! glial cell migration GO:0008347 11 5 0,000 0,01534574 0,06365835 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01534574 0,06354878 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,01534574 0,06343959 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01534574 0,06333078 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01534574 0,06322233 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01534574 0,06311426 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01534574 0,06300656 ! neuroprotection GO:0043526 6 5 0,000 0,01534574 0,06289922 ! neural plate development GO:0001840 8 5 0,000 0,01534574 0,06279225 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01534574 0,06268564 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01534574 0,06257939 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,01534574 0,06247351 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,01534574 0,06236798 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01534574 0,0622628 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01534574 0,06215798 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01534574 0,06205352 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01534574 0,0619494 ! spindle assembly GO:0051225 6 5 0,000 0,01534574 0,06184563 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,01534574 0,06174221 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01534574 0,06163914 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01534574 0,0615364 ! drug metabolic process GO:0017144 6 5 0,000 0,01534574 0,06143401 ! stem cell division GO:0017145 11 5 0,000 0,01534574 0,06133196 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01534574 0,06123025 ! organ regeneration GO:0031100 7 5 0,000 0,01534574 0,06112888 ! carnitine metabolic process GO:0009437 7 5 0,000 0,01534574 0,06102784 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,01534574 0,06092713 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01534574 0,06082676 ! regulation of homeostatic process GO:0032844 134 62 1,000 0,01581845 0,06259736 ! regulation of cellular response to stress GO:0080135 128 67 1,000 0,0183124 0,07234751 ! negative regulation of cell growth GO:0030308 132 67 1,000 0,0183124 0,0722289 ! lung development GO:0030324 144 67 1,000 0,0183124 0,07211069 ! chromosome segregation GO:0007059 113 67 1,000 0,0183124 0,07199286 ! adaptive immune response GO:0002250 119 67 1,000 0,0183124 0,07187542 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01838681 0,07204995 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01838681 0,0719328 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,01838681 0,07181602 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01838681 0,07169963 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01838681 0,07158361 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,01838681 0,07146796 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,01838681 0,07135269 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01838681 0,07123779 ! response to oxygen radical GO:0000305 11 6 0,000 0,01838681 0,07112326 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,01838681 0,0710091 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,01838681 0,0708953 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,01838681 0,07078187 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,01838681 0,0706688 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01838681 0,07055609 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01838681 0,07044374 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,01838681 0,07033175 ! forebrain regionalization GO:0021871 8 6 0,000 0,01838681 0,07022011 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01838681 0,07010883 ! male meiosis GO:0007140 7 6 0,000 0,01838681 0,06999789 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01838681 0,06988731 ! response to zinc ion GO:0010043 9 6 0,000 0,01838681 0,06977708 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01838681 0,0696672 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,01838681 0,06955766 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,01838681 0,06944846 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01838681 0,06933961 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01838681 0,06923109 ! malate metabolic process GO:0006108 11 6 0,000 0,01838681 0,06912292 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,01838681 0,06901508 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,01838681 0,06890758 ! protein refolding GO:0042026 15 6 0,000 0,01838681 0,06880042 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01838681 0,06869359 ! opsonization GO:0008228 8 6 0,000 0,01838681 0,06858708 ! mating behavior GO:0007617 7 6 0,000 0,01838681 0,06848091 ! neuron remodeling GO:0016322 15 6 0,000 0,01838681 0,06837507 ! erythrocyte maturation GO:0043249 7 6 0,000 0,01838681 0,06826955 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,01838681 0,06816436 ! equilibrioception GO:0050957 14 6 0,000 0,01838681 0,06805949 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,01838681 0,06795494 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,01838681 0,06785072 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01838681 0,06774681 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,01838681 0,06764322 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01838681 0,06753995 ! response to interferon-gamma GO:0034341 15 6 0,000 0,01838681 0,067437 ! toxin metabolic process GO:0009404 11 6 0,000 0,01838681 0,06733435 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01838681 0,06723202 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01838681 0,06713 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,01838681 0,06702829 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,01838681 0,06692688 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,01838681 0,06682578 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01838681 0,06672499 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,01838681 0,0666245 ! thymic T cell selection GO:0045061 12 6 0,000 0,01838681 0,06652431 ! protein lipoylation GO:0009249 10 6 0,000 0,01838681 0,06642443 ! cysteine metabolic process GO:0006534 10 6 0,000 0,01838681 0,06632484 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01838681 0,06622555 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01838681 0,06612656 ! glutamate catabolic process GO:0006538 10 6 0,000 0,01838681 0,06602786 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,01838681 0,06592946 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01838681 0,06583135 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,01838681 0,06573353 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,01838681 0,06563601 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01838681 0,06553877 ! hyperosmotic response GO:0006972 9 6 0,000 0,01838681 0,06544182 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,01838681 0,06534515 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,01838681 0,06524877 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01838681 0,06515268 ! urea metabolic process GO:0019627 7 6 0,000 0,01838681 0,06505687 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01838681 0,06496133 ! neutrophil activation GO:0042119 8 6 0,000 0,01838681 0,06486608 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01838681 0,06477111 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,01838681 0,06467642 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01838681 0,064582 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01838681 0,06448786 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01838681 0,06439399 ! neuron apoptosis GO:0051402 9 6 0,000 0,01838681 0,06430039 ! nucleoside salvage GO:0043174 9 6 0,000 0,01838681 0,06420707 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,01838681 0,06411401 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01838681 0,06402123 ! T cell mediated immunity GO:0002456 16 6 0,000 0,01838681 0,06392871 ! carnitine transport GO:0015879 10 6 0,000 0,01838681 0,06383646 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,01838681 0,06374448 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01838681 0,06365276 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,01838681 0,06356131 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,01838681 0,06347011 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,01838681 0,06337918 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01838681 0,06328851 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,01838681 0,0631981 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,01838681 0,06310794 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,01838681 0,06301805 ! establishment of spindle localization GO:0051293 12 6 0,000 0,01838681 0,06292841 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,01838681 0,06283902 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01838681 0,06274989 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 12 6 0,000 0,01838681 0,062661 ! neural nucleus development GO:0048857 14 6 0,000 0,01838681 0,06257237 ! response to UV-C GO:0010225 11 6 0,000 0,01838681 0,062484 ! astrocyte development GO:0014002 15 6 0,000 0,01838681 0,06239587 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,01838681 0,06230798 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01838681 0,06222035 ! interaction with symbiont GO:0051702 13 6 0,000 0,01838681 0,06213296 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01838681 0,06204582 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01838681 0,06195892 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,01838681 0,06187226 ! response to copper ion GO:0046688 10 6 0,000 0,01838681 0,06178585 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,01838681 0,06169968 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,01838681 0,06161375 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01838681 0,06152805 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01838681 0,0614426 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01838681 0,06135738 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,01838681 0,06127239 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01838681 0,06118765 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,01838681 0,06110313 ! hair follicle maturation GO:0048820 7 6 0,000 0,01838681 0,06101885 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01838681 0,06093481 ! Schwann cell development GO:0014044 15 6 0,000 0,01838681 0,06085099 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,01838681 0,0607674 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01838681 0,06068405 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,01838681 0,06060092 ! subpallium development GO:0021544 10 6 0,000 0,01838681 0,06051802 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,01838681 0,06043534 ! histone ubiquitination GO:0016574 8 6 0,000 0,01838681 0,06035289 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,01838681 0,06027067 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01838681 0,06018867 ! G2 phase GO:0051319 16 6 0,000 0,01838681 0,06010689 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,01838681 0,06002533 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01838681 0,059944 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,01838681 0,05986288 ! membrane to membrane docking GO:0022614 14 6 0,000 0,01838681 0,05978199 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01838681 0,05970131 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,01838681 0,05962085 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01838681 0,0595406 ! receptor internalization GO:0031623 10 6 0,000 0,01838681 0,05946058 ! neutrophil homeostasis GO:0001780 10 6 0,000 0,01838681 0,05938076 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01838681 0,05930116 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,01838681 0,05922178 ! protein deubiquitination GO:0016579 14 6 0,000 0,01838681 0,05914261 ! negative regulation of neuroblast proliferation GO:0007406 21 6 0,000 0,01838681 0,05906364 ! protein destabilization GO:0031648 9 6 0,000 0,01838681 0,05898489 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01838681 0,05890635 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,01838681 0,05882802 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01838681 0,05874989 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,01838681 0,05867197 ! progesterone metabolic process GO:0042448 10 6 0,000 0,01838681 0,05859426 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,01838681 0,05851676 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,01838681 0,05843946 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,01838681 0,05836236 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,01838681 0,05828547 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01838681 0,05820878 ! determination of adult lifespan GO:0008340 15 6 0,000 0,01838681 0,05813229 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,01838681 0,058056 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,01838681 0,05797991 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01838681 0,05790402 ! catecholamine transport GO:0051937 9 6 0,000 0,01838681 0,05782833 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,01838681 0,05775283 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01838681 0,05767753 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01838681 0,05760243 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,01838681 0,05752753 ! maternal placenta development GO:0001893 12 6 0,000 0,01838681 0,05745282 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,01838681 0,0573783 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01838681 0,05730398 ! negative regulation of B cell activation GO:0050869 13 6 0,000 0,01838681 0,05722984 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,01838681 0,0571559 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01838681 0,05708215 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,01838681 0,05700859 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,01838681 0,05693522 ! regulation of lipase activity GO:0060191 130 68 1,000 0,01882988 0,05823226 ! negative regulation of cell size GO:0045792 134 69 1,000 0,0193535 0,05977474 ! respiratory tube development GO:0030323 150 70 1,000 0,01988321 0,06133206 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,02041897 0,06290402 ! acute inflammatory response GO:0002526 113 72 1,000 0,02096074 0,06449045 ! regulation of caspase activity GO:0043281 122 72 1,000 0,02096074 0,06440809 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,02096074 0,06432594 ! respiratory system development GO:0060541 153 72 1,000 0,02096074 0,06424399 ! tRNA transcription GO:0009304 14 7 0,000 0,0214186 0,06556379 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,0214186 0,06548048 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,0214186 0,06539739 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,0214186 0,0653145 ! regulation of helicase activity GO:0051095 15 7 0,000 0,0214186 0,06523182 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,0214186 0,06514935 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,0214186 0,0650671 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,0214186 0,06498504 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,0214186 0,0649032 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,0214186 0,06482156 ! prostate gland development GO:0030850 13 7 0,000 0,0214186 0,06474013 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,0214186 0,0646589 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0214186 0,06457787 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,0214186 0,06449705 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,0214186 0,06441642 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0214186 0,064336 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,0214186 0,06425579 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,0214186 0,06417577 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,0214186 0,06409594 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,0214186 0,06401632 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,0214186 0,0639369 ! glycolipid transport GO:0046836 10 7 0,000 0,0214186 0,06385767 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,0214186 0,06377864 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,0214186 0,0636998 ! N-terminal protein amino acid acetylation GO:0006474 13 7 0,000 0,0214186 0,06362116 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,0214186 0,06354271 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,0214186 0,06346446 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,0214186 0,0633864 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,0214186 0,06330853 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,0214186 0,06323085 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,0214186 0,06315336 ! pericardium development GO:0060039 14 7 0,000 0,0214186 0,06307606 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,0214186 0,06299895 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,0214186 0,06292203 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0214186 0,06284529 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,0214186 0,06276874 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,0214186 0,06269238 ! lipoprotein transport GO:0042953 14 7 0,000 0,0214186 0,06261621 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0214186 0,06254022 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0214186 0,06246441 ! rhythmic behavior GO:0007622 15 7 0,000 0,0214186 0,06238879 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,0214186 0,06231335 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,0214186 0,06223809 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,0214186 0,06216302 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,0214186 0,06208812 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,0214186 0,06201341 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,0214186 0,06193887 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,0214186 0,06186451 ! mechanosensory behavior GO:0007638 14 7 0,000 0,0214186 0,06179034 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,0214186 0,06171633 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0214186 0,06164251 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,0214186 0,06156886 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0214186 0,06149539 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0214186 0,0614221 ! spinal cord patterning GO:0021511 13 7 0,000 0,0214186 0,06134898 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,0214186 0,06127603 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,0214186 0,06120325 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,0214186 0,06113065 ! adrenal gland development GO:0030325 17 7 0,000 0,0214186 0,06105822 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,0214186 0,06098596 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,0214186 0,06091388 ! ovulation GO:0030728 9 7 0,000 0,0214186 0,06084196 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,0214186 0,06077021 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,0214186 0,06069863 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,0214186 0,06062722 ! microtubule nucleation GO:0007020 20 7 0,000 0,0214186 0,06055598 ! proline biosynthetic process GO:0006561 10 7 0,000 0,0214186 0,06048491 ! thyroid hormone generation GO:0006590 13 7 0,000 0,0214186 0,060414 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,0214186 0,06034325 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,0214186 0,06027268 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,0214186 0,06020227 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0214186 0,06013202 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0214186 0,06006193 ! galactose metabolic process GO:0006012 13 7 0,000 0,0214186 0,05999201 ! vesicle fusion GO:0006906 17 7 0,000 0,0214186 0,05992226 ! response to dietary excess GO:0002021 8 7 0,000 0,0214186 0,05985266 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,0214186 0,05978322 ! intracellular pH reduction GO:0051452 11 7 0,000 0,0214186 0,05971395 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,0214186 0,05964484 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,0214186 0,05957588 ! purine salvage GO:0043101 10 7 0,000 0,0214186 0,05950709 ! nucleoside transport GO:0015858 8 7 0,000 0,0214186 0,05943845 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,0214186 0,05936998 ! parturition GO:0007567 14 7 0,000 0,0214186 0,05930166 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,0214186 0,05923349 ! rRNA modification GO:0000154 14 7 0,000 0,0214186 0,05916549 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,0214186 0,05909764 ! spindle checkpoint GO:0031577 15 7 0,000 0,0214186 0,05902994 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,0214186 0,0589624 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,0214186 0,05889502 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0214186 0,05882778 ! centrosome duplication GO:0051298 13 7 0,000 0,0214186 0,05876071 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,0214186 0,05869378 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,0214186 0,05862701 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,0214186 0,05856039 ! fibrinolysis GO:0042730 10 7 0,000 0,0214186 0,05849392 ! eating behavior GO:0042755 7 7 0,000 0,0214186 0,0584276 ! B cell lineage commitment GO:0002326 21 7 0,000 0,0214186 0,05836143 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,0214186 0,05829541 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,0214186 0,05822954 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,0214186 0,05816381 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,0214186 0,05809824 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,0214186 0,05803281 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,0214186 0,05796754 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,0214186 0,0579024 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,0214186 0,05783742 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,0214186 0,05777258 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,0214186 0,05770788 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,0214186 0,05764333 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,0214186 0,05757893 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,0214186 0,05751466 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,0214186 0,05745055 ! regulation of meiosis GO:0040020 12 7 0,000 0,0214186 0,05738657 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,0214186 0,05732274 ! T cell lineage commitment GO:0002360 16 7 0,000 0,0214186 0,05725904 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,0214186 0,05719549 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,0214186 0,05713208 ! oxygen homeostasis GO:0032364 12 7 0,000 0,0214186 0,05706881 ! transcription termination GO:0006353 13 7 0,000 0,0214186 0,05700569 ! response to tumor cell GO:0002347 13 7 0,000 0,0214186 0,0569427 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,0214186 0,05687985 ! anaphase GO:0051322 17 7 0,000 0,0214186 0,05681713 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,0214186 0,05675456 ! axonal fasciculation GO:0007413 18 7 0,000 0,0214186 0,05669212 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,0214186 0,05662982 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,0214186 0,05656766 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,0214186 0,05650564 ! diuresis GO:0030146 12 7 0,000 0,0214186 0,05644375 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,0214186 0,05638199 ! thiamin metabolic process GO:0006772 7 7 0,000 0,0214186 0,05632037 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0214186 0,05625889 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,0214186 0,05619754 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,0214186 0,05613632 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,0214186 0,05607523 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0214186 0,05601428 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0214186 0,05595346 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0214186 0,05589278 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,0214186 0,05583222 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,0214186 0,0557718 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,0214186 0,0557115 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,0214186 0,05565134 ! lymph node development GO:0048535 10 7 0,000 0,0214186 0,0555913 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,0214186 0,0555314 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0214186 0,05547163 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,0214186 0,05541198 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,0214186 0,05535246 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,0214186 0,05529307 ! adult feeding behavior GO:0008343 9 7 0,000 0,0214186 0,0552338 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,0214186 0,05517467 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,0214186 0,05511566 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,0214186 0,05505677 ! muscle adaptation GO:0043500 14 7 0,000 0,0214186 0,05499801 ! embryonic heart tube development GO:0035050 10 7 0,000 0,0214186 0,05493938 ! retina homeostasis GO:0001895 12 7 0,000 0,0214186 0,05488087 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,0214186 0,05482249 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,0214186 0,05476423 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,0214186 0,05470609 ! protein prenylation GO:0018342 18 7 0,000 0,0214186 0,05464808 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,0214186 0,05459019 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,0214186 0,05453242 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0214186 0,05447478 ! learning or memory GO:0007611 147 73 1,000 0,02150847 0,0546456 ! axon guidance GO:0007411 139 73 1,000 0,02150847 0,05458795 ! meiosis GO:0007126 121 74 1,000 0,02206213 0,05593412 GO:0051327|M phase of meiotic cell cycle, ! regulation of endopeptidase activity GO:0052548 125 74 1,000 0,02206213 0,05587524 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,02262167 0,05723212 ! phosphoinositide-mediated signaling GO:0048015 131 75 1,000 0,02262167 0,057172 ! regulation of vesicle-mediated transport GO:0060627 119 75 1,000 0,02262167 0,05711201 ! meiotic cell cycle GO:0051321 122 75 1,000 0,02262167 0,05705214 ! positive regulation of lymphocyte activation GO:0051251 127 77 1,000 0,02375825 0,05985586 ! protein oligomerization GO:0051259 139 78 1,000 0,0243352 0,06124528 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,02444111 0,06144757 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,02444111 0,06138343 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,02444111 0,06131942 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,02444111 0,06125554 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,02444111 0,0611918 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02444111 0,06112819 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02444111 0,06106472 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,02444111 0,06100137 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,02444111 0,06093816 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,02444111 0,06087507 ! meiotic prophase I GO:0007128 13 8 0,000 0,02444111 0,06081212 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02444111 0,0607493 ! oligopeptide transport GO:0006857 15 8 0,000 0,02444111 0,06068661 ! UTP metabolic process GO:0046051 8 8 0,000 0,02444111 0,06062404 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,02444111 0,06056161 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,02444111 0,0604993 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,02444111 0,06043712 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02444111 0,06037507 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02444111 0,06031315 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02444111 0,06025135 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,02444111 0,06018968 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,02444111 0,06012814 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02444111 0,06006672 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02444111 0,06000543 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,02444111 0,05994426 ! reflex GO:0060004 16 8 0,000 0,02444111 0,05988322 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,02444111 0,0598223 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,02444111 0,05976151 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02444111 0,05970083 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,02444111 0,05964029 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,02444111 0,05957986 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,02444111 0,05951956 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02444111 0,05945938 ! pigment granule organization GO:0048753 16 8 0,000 0,02444111 0,05939932 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02444111 0,05933938 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,02444111 0,05927956 ! astrocyte differentiation GO:0048708 18 8 0,000 0,02444111 0,05921986 ! histidine metabolic process GO:0006547 16 8 0,000 0,02444111 0,05916028 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02444111 0,05910083 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,02444111 0,05904149 ! glycine catabolic process GO:0006546 13 8 0,000 0,02444111 0,05898227 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,02444111 0,05892317 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,02444111 0,05886419 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 12 8 0,000 0,02444111 0,05880532 ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,02444111 0,05874658 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,02444111 0,05868795 ! melanin metabolic process GO:0006582 15 8 0,000 0,02444111 0,05862943 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,02444111 0,05857104 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02444111 0,05851276 ! macrophage activation GO:0042116 12 8 0,000 0,02444111 0,05845459 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02444111 0,05839655 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02444111 0,05833861 ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,02444111 0,0582808 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02444111 0,05822309 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,02444111 0,0581655 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,02444111 0,05810803 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,02444111 0,05805066 ! osteoblast development GO:0002076 16 8 0,000 0,02444111 0,05799341 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,02444111 0,05793628 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,02444111 0,05787925 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,02444111 0,05782234 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,02444111 0,05776554 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,02444111 0,05770885 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02444111 0,05765228 ! response to UV-B GO:0010224 16 8 0,000 0,02444111 0,05759581 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,02444111 0,05753945 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02444111 0,05748321 ! intermediate filament organization GO:0045109 12 8 0,000 0,02444111 0,05742707 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,02444111 0,05737105 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,02444111 0,05731513 ! cellular extravasation GO:0045123 12 8 0,000 0,02444111 0,05725932 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,02444111 0,05720362 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,02444111 0,05714803 ! response to antibiotic GO:0046677 11 8 0,000 0,02444111 0,05709255 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,02444111 0,05703717 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,02444111 0,0569819 ! DNA topological change GO:0006265 12 8 0,000 0,02444111 0,05692674 ! response to tropane GO:0014073 15 8 0,000 0,02444111 0,05687168 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,02444111 0,05681674 ! melanosome transport GO:0032402 13 8 0,000 0,02444111 0,05676189 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,02444111 0,05670716 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02444111 0,05665253 ! mast cell activation GO:0045576 14 8 0,000 0,02444111 0,056598 ! multicellular organismal aging GO:0010259 18 8 0,000 0,02444111 0,05654358 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,02444111 0,05648926 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,02444111 0,05643505 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,02444111 0,05638094 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02444111 0,05632694 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02444111 0,05627304 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02444111 0,05621924 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02444111 0,05616554 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,02444111 0,05611195 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,02444111 0,05605846 ! intracellular lipid transport GO:0032365 13 8 0,000 0,02444111 0,05600507 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02444111 0,05595178 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02444111 0,0558986 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,02444111 0,05584551 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,02444111 0,05579253 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02444111 0,05573964 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,02444111 0,05568686 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,02444111 0,05563417 ! hormone catabolic process GO:0042447 17 8 0,000 0,02444111 0,05558159 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02444111 0,05552911 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,02444111 0,05547672 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,02444111 0,05542443 ! ATP catabolic process GO:0006200 11 8 0,000 0,02444111 0,05537224 ! blastocyst growth GO:0001832 19 8 0,000 0,02444111 0,05532015 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02444111 0,05526816 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02444111 0,05521626 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,02444111 0,05516447 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02444111 0,05511277 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02444111 0,05506116 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,02444111 0,05500966 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,02444111 0,05495825 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,02444111 0,05490693 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,02444111 0,05485571 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,02444111 0,05480459 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,02444111 0,05475356 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,02444111 0,05470263 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02444111 0,05465179 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02444111 0,05460104 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,02444111 0,05455039 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 1,000 0,02491787 0,05556293 ! activation of protein kinase activity GO:0032147 147 79 1,000 0,02491787 0,05551149 ! regulation of peptidase activity GO:0052547 134 79 1,000 0,02491787 0,05546013 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,02491787 0,05540888 ! cellular lipid catabolic process GO:0044242 134 80 1,000 0,02550623 0,05666481 ! cell-substrate adhesion GO:0031589 171 81 1,000 0,02610023 0,05793095 ! response to drug GO:0042493 143 82 1,000 0,02669983 0,05920718 ! axon extension GO:0048675 15 9 0,000 0,0274544 0,06082439 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,0274544 0,06076843 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,0274544 0,06071258 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,0274544 0,06065683 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,0274544 0,06060118 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,0274544 0,06054563 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,0274544 0,06049019 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,0274544 0,06043484 ! phosphate transport GO:0006817 19 9 0,000 0,0274544 0,0603796 ! reproductive behavior GO:0019098 19 9 0,000 0,0274544 0,06032446 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,0274544 0,06026942 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,0274544 0,06021448 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0274544 0,06015964 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,0274544 0,0601049 ! GTP metabolic process GO:0046039 9 9 0,000 0,0274544 0,06005026 ! RNA methylation GO:0001510 15 9 0,000 0,0274544 0,05999572 ! elastic fiber assembly GO:0048251 15 9 0,000 0,0274544 0,05994127 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,0274544 0,05988693 ! artery development GO:0060840 24 9 0,000 0,0274544 0,05983268 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,0274544 0,05977854 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,0274544 0,05972449 ! chemosensory behavior GO:0007635 20 9 0,000 0,0274544 0,05967054 ! microtubule bundle formation GO:0001578 21 9 0,000 0,0274544 0,05961668 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,0274544 0,05956293 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,0274544 0,05950927 ! leukocyte degranulation GO:0043299 16 9 0,000 0,0274544 0,0594557 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,0274544 0,05940223 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,0274544 0,05934886 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,0274544 0,05929559 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,0274544 0,05924241 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,0274544 0,05918932 ! protein targeting to ER GO:0045047 22 9 0,000 0,0274544 0,05913633 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,0274544 0,05908344 ! T cell selection GO:0045058 23 9 0,000 0,0274544 0,05903064 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,0274544 0,05897793 ! endosome organization GO:0007032 17 9 0,000 0,0274544 0,05892532 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,0274544 0,0588728 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0274544 0,05882038 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,0274544 0,05876805 ! mannose metabolic process GO:0006013 13 9 0,000 0,0274544 0,05871581 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,0274544 0,05866366 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,0274544 0,05861161 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,0274544 0,05855965 ! receptor clustering GO:0043113 18 9 0,000 0,0274544 0,05850778 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,0274544 0,058456 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,0274544 0,05840432 ! ruffle organization GO:0031529 15 9 0,000 0,0274544 0,05835272 ! retinol metabolic process GO:0042572 18 9 0,000 0,0274544 0,05830122 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,0274544 0,05824981 ! behavioral fear response GO:0001662 22 9 0,000 0,0274544 0,05819849 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,0274544 0,05814726 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,0274544 0,05809612 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,0274544 0,05804507 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,0274544 0,0579941 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,0274544 0,05794323 ! segment specification GO:0007379 13 9 0,000 0,0274544 0,05789245 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,0274544 0,05784175 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,0274544 0,05779115 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,0274544 0,05774063 ! establishment of melanosome localization GO:0032401 14 9 0,000 0,0274544 0,0576902 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,0274544 0,05763986 ! erythrocyte development GO:0048821 15 9 0,000 0,0274544 0,05758961 ! gas homeostasis GO:0033483 16 9 0,000 0,0274544 0,05753945 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,0274544 0,05748937 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,0274544 0,05743938 ! renal water homeostasis GO:0003091 14 9 0,000 0,0274544 0,05738947 ! postreplication repair GO:0006301 22 9 0,000 0,0274544 0,05733966 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,0274544 0,05728993 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,0274544 0,05724028 ! icosanoid secretion GO:0032309 15 9 0,000 0,0274544 0,05719072 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,0274544 0,05714125 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,0274544 0,05709186 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,0274544 0,05704256 ! regulation of cell division GO:0051302 15 9 0,000 0,0274544 0,05699334 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,0274544 0,05694421 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,0274544 0,05689516 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,0274544 0,0568462 ! sterol catabolic process GO:0016127 11 9 0,000 0,0274544 0,05679732 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,0274544 0,05674853 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,0274544 0,05669981 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,0274544 0,05665119 GO:0002820|negative regulation of adaptive immune response, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,0274544 0,05660264 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,0274544 0,05655418 ! musculoskeletal movement GO:0050881 14 9 0,000 0,0274544 0,0565058 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,0274544 0,05645751 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,0274544 0,05640929 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,0274544 0,05636116 ! purine base metabolic process GO:0006144 21 9 0,000 0,0274544 0,05631312 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,0274544 0,05626515 ! pigment granule transport GO:0051904 17 9 0,000 0,0274544 0,05621726 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,0274544 0,05616946 ! regulation of telomere maintenance GO:0032204 14 9 0,000 0,0274544 0,05612174 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,0274544 0,0560741 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,0274544 0,05602653 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0274544 0,05597905 ! mitochondrion localization GO:0051646 15 9 0,000 0,0274544 0,05593165 ! negative regulation of growth GO:0045926 155 84 1,000 0,02791569 0,0568233 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,02791569 0,05677527 ! positive regulation of cell activation GO:0050867 145 85 1,000 0,02853186 0,05797944 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 148 86 1,000 0,02915348 0,05919264 ! regulation of DNA binding GO:0051101 155 88 1,000 0,03041291 0,06169769 ! gland development GO:0048732 206 88 1,000 0,03041291 0,06164571 ! regulation of neurological system process GO:0031644 148 88 1,000 0,03041291 0,06159382 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,03045848 0,06163422 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03045848 0,06158243 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03045848 0,06153072 ! synapsis GO:0007129 13 10 0,000 0,03045848 0,0614791 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,03045848 0,06142757 ! N-glycan processing GO:0006491 20 10 0,000 0,03045848 0,06137612 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,03045848 0,06132476 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,03045848 0,06127349 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,03045848 0,0612223 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,03045848 0,0611712 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 0,000 0,03045848 0,06112018 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,03045848 0,06106924 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,03045848 0,0610184 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,03045848 0,06096763 ! androgen metabolic process GO:0008209 17 10 0,000 0,03045848 0,06091695 ! phospholipid efflux GO:0033700 16 10 0,000 0,03045848 0,06086636 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03045848 0,06081584 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,03045848 0,06076542 ! pathogenesis GO:0009405 13 10 0,000 0,03045848 0,06071507 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03045848 0,06066481 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,03045848 0,06061463 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,03045848 0,06056454 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,03045848 0,06051453 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,03045848 0,0604646 ! endoderm development GO:0007492 16 10 0,000 0,03045848 0,06041475 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,03045848 0,06036499 ! arginine catabolic process GO:0006527 13 10 0,000 0,03045848 0,0603153 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03045848 0,0602657 ! proline metabolic process GO:0006560 13 10 0,000 0,03045848 0,06021618 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03045848 0,06016674 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,03045848 0,06011739 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,03045848 0,06006811 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03045848 0,06001891 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,03045848 0,0599698 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,03045848 0,05992076 ! B cell proliferation GO:0042100 18 10 0,000 0,03045848 0,05987181 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,03045848 0,05982293 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,03045848 0,05977414 ! multicellular organism growth GO:0035264 18 10 0,000 0,03045848 0,05972542 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,03045848 0,05967679 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,03045848 0,05962823 ! epithelial cell development GO:0002064 20 10 0,000 0,03045848 0,05957975 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,03045848 0,05953135 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03045848 0,05948303 ! macroautophagy GO:0016236 17 10 0,000 0,03045848 0,05943479 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,03045848 0,05938662 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,03045848 0,05933854 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,03045848 0,05929053 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,03045848 0,0592426 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 0,000 0,03045848 0,05919474 ! copper ion homeostasis GO:0055070 13 10 0,000 0,03045848 0,05914697 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,03045848 0,05909927 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,03045848 0,05905165 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,03045848 0,0590041 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,03045848 0,05895663 ! blastoderm segmentation GO:0007350 18 10 0,000 0,03045848 0,05890924 ! response to dsRNA GO:0043331 20 10 0,000 0,03045848 0,05886192 ! DNA ligation GO:0006266 19 10 0,000 0,03045848 0,05881468 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03045848 0,05876752 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03045848 0,05872043 ! melanosome localization GO:0032400 16 10 0,000 0,03045848 0,05867341 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,03045848 0,05862647 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,03045848 0,05857961 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,03045848 0,05853282 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03045848 0,05848611 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,03045848 0,05843947 ! mRNA cleavage GO:0006379 17 10 0,000 0,03045848 0,0583929 ! protein sumoylation GO:0016925 15 10 0,000 0,03045848 0,05834641 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03045848 0,05829999 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03045848 0,05825365 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03045848 0,05820738 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,03045848 0,05816118 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,03045848 0,05811506 ! salivary gland development GO:0007431 27 10 0,000 0,03045848 0,05806901 ! prophase GO:0051324 15 10 0,000 0,03045848 0,05802303 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03045848 0,05797713 ! apical protein localization GO:0045176 15 10 0,000 0,03045848 0,0579313 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,03045848 0,05788554 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,03045848 0,05783985 ! midbrain development GO:0030901 13 10 0,000 0,03045848 0,05779424 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03045848 0,05774869 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,03045848 0,05770322 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,03045848 0,05765782 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,03045848 0,05761249 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03045848 0,05756724 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03045848 0,05752205 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,03045848 0,05747694 ! detection of calcium ion GO:0005513 23 10 0,000 0,03045848 0,05743189 ! oocyte development GO:0048599 17 10 0,000 0,03045848 0,05738692 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03045848 0,05734201 ! blastocyst formation GO:0001825 17 10 0,000 0,03045848 0,05729718 ! cerebellar cortex development GO:0021695 15 10 0,000 0,03045848 0,05725242 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,03045848 0,05720772 ! activation of innate immune response GO:0002218 12 10 0,000 0,03045848 0,0571631 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,03045848 0,05711854 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,03045848 0,05707406 ! response to nicotine GO:0035094 20 10 0,000 0,03045848 0,05702964 ! establishment of cell polarity GO:0030010 16 10 0,000 0,03045848 0,0569853 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,03045848 0,05694102 ! regulation of cell morphogenesis GO:0022604 215 89 1,000 0,03105063 0,05800297 ! regulation of cell adhesion GO:0030155 212 89 1,000 0,03105063 0,05795797 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,03345337 0,06239443 ! respiratory burst GO:0045730 17 11 0,000 0,03345337 0,0623461 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,03345337 0,06229784 ! neuron fate specification GO:0048665 17 11 0,000 0,03345337 0,06224966 ! telencephalon cell migration GO:0022029 20 11 0,000 0,03345337 0,06220156 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,03345337 0,06215352 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,03345337 0,06210557 ! thyroid gland development GO:0030878 26 11 0,000 0,03345337 0,06205768 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,03345337 0,06200987 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,03345337 0,06196214 ! response to pain GO:0048265 24 11 0,000 0,03345337 0,06191447 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03345337 0,06186688 ! T cell proliferation GO:0042098 26 11 0,000 0,03345337 0,06181937 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 0,000 0,03345337 0,06177192 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,03345337 0,06172455 ! peptide or protein amino-terminal blocking GO:0018409 21 11 0,000 0,03345337 0,06167725 ! ventral spinal cord development GO:0021517 21 11 0,000 0,03345337 0,06163003 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03345337 0,06158287 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,03345337 0,06153579 ! melanocyte differentiation GO:0030318 21 11 0,000 0,03345337 0,06148878 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,03345337 0,06144184 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,03345337 0,06139498 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,03345337 0,06134818 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,03345337 0,06130146 ! lipid digestion GO:0044241 18 11 0,000 0,03345337 0,06125481 ! UV protection GO:0009650 19 11 0,000 0,03345337 0,06120822 ! adult heart development GO:0007512 14 11 0,000 0,03345337 0,06116171 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03345337 0,06111527 ! temperature homeostasis GO:0001659 17 11 0,000 0,03345337 0,0610689 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,03345337 0,0610226 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,03345337 0,06097637 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,03345337 0,06093022 ! regulation of organ growth GO:0046620 13 11 0,000 0,03345337 0,06088413 ! pigment granule localization GO:0051875 20 11 0,000 0,03345337 0,06083811 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,03345337 0,06079216 ! vasoconstriction GO:0042310 18 11 0,000 0,03345337 0,06074628 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03345337 0,06070046 ! embryonic axis specification GO:0000578 18 11 0,000 0,03345337 0,06065472 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,03345337 0,06060905 ! snRNA metabolic process GO:0016073 24 11 0,000 0,03345337 0,06056344 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03345337 0,06051791 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,03345337 0,06047244 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03345337 0,06042704 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,03345337 0,06038171 ! zymogen activation GO:0031638 15 11 0,000 0,03345337 0,06033644 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,03345337 0,06029125 ! neuroblast proliferation GO:0007405 24 11 0,000 0,03345337 0,06024612 ! nucleosome positioning GO:0016584 15 11 0,000 0,03345337 0,06020106 ! regulation of isotype switching GO:0045191 22 11 0,000 0,03345337 0,06015606 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,03345337 0,06011114 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,03345337 0,06006628 ! acid secretion GO:0046717 18 11 0,000 0,03345337 0,06002149 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03345337 0,05997676 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,03345337 0,0599321 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,03345337 0,05988751 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,03345337 0,05984298 ! oocyte differentiation GO:0009994 18 11 0,000 0,03345337 0,05979853 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,03345337 0,05975413 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,03345337 0,0597098 ! cholesterol efflux GO:0033344 19 11 0,000 0,03345337 0,05966554 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,03345337 0,05962134 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03345337 0,05957721 ! germ cell migration GO:0008354 25 11 0,000 0,03345337 0,05953315 ! embryonic gut development GO:0048566 15 11 0,000 0,03345337 0,05948915 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,03345337 0,05944521 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,03345337 0,05940134 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,03345337 0,05935753 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,03345337 0,05931379 ! defense response to fungus GO:0050832 13 11 0,000 0,03345337 0,05927011 ! developmental induction GO:0031128 19 11 0,000 0,03345337 0,0592265 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,03345337 0,05918295 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03345337 0,05913947 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,03345337 0,05909605 ! sequestering of metal ion GO:0051238 14 11 0,000 0,03345337 0,05905269 ! lamellipodium assembly GO:0030032 20 11 0,000 0,03345337 0,05900939 ! regulation of synapse organization GO:0050807 17 11 0,000 0,03345337 0,05896616 ! regulation of T cell activation GO:0050863 158 94 1,000 0,0343179 0,06044573 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,03643912 0,06413498 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,03643912 0,0640881 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,03643912 0,06404128 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,03643912 0,06399454 ! mating GO:0007618 17 12 0,000 0,03643912 0,06394786 ! protein complex disassembly GO:0043241 27 12 0,000 0,03643912 0,06390125 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03643912 0,06385471 ! hippocampus development GO:0021766 26 12 0,000 0,03643912 0,06380824 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,03643912 0,06376183 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,03643912 0,06371549 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03643912 0,06366922 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,03643912 0,06362302 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,03643912 0,06357688 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,03643912 0,06353081 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,03643912 0,06348481 ! drug transport GO:0015893 16 12 0,000 0,03643912 0,06343887 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,03643912 0,063393 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,03643912 0,06334719 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,03643912 0,06330146 ! polyamine metabolic process GO:0006595 17 12 0,000 0,03643912 0,06325578 ! focal adhesion formation GO:0048041 35 12 0,000 0,03643912 0,06321018 ! mitotic spindle organization GO:0007052 21 12 0,000 0,03643912 0,06316464 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,03643912 0,06311916 ! forebrain cell migration GO:0021885 21 12 0,000 0,03643912 0,06307375 ! asymmetric protein localization GO:0008105 20 12 0,000 0,03643912 0,06302841 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,03643912 0,06298313 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,03643912 0,06293792 ! fear response GO:0042596 26 12 0,000 0,03643912 0,06289277 ! monoamine transport GO:0015844 18 12 0,000 0,03643912 0,06284768 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03643912 0,06280266 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,03643912 0,06275771 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,03643912 0,06271282 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,03643912 0,06266799 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03643912 0,06262323 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,03643912 0,06257853 ! protein homotetramerization GO:0051289 21 12 0,000 0,03643912 0,06253389 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,03643912 0,06248932 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03643912 0,06244481 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,03643912 0,06240037 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,03643912 0,06235599 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03643912 0,06231167 ! cranial nerve development GO:0021545 20 12 0,000 0,03643912 0,06226741 ! fucose catabolic process GO:0019317 22 12 0,000 0,03643912 0,06222322 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,03643912 0,06217909 ! histone acetylation GO:0016573 26 12 0,000 0,03643912 0,06213502 ! histone methylation GO:0016571 26 12 0,000 0,03643912 0,06209102 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,03643912 0,06204707 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03643912 0,06200319 ! gland morphogenesis GO:0022612 29 12 0,000 0,03643912 0,06195938 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,03643912 0,06191562 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,03643912 0,06187192 ! T cell homeostasis GO:0043029 25 12 0,000 0,03643912 0,06182829 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,03643912 0,06178472 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,03643912 0,06174121 ! spleen development GO:0048536 22 12 0,000 0,03643912 0,06169776 ! digestive tract morphogenesis GO:0048546 26 12 0,000 0,03643912 0,06165437 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,03643912 0,06161104 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,03643912 0,06156778 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,03643912 0,06152457 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,03643912 0,06148143 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,03643912 0,06143834 ! response to cold GO:0009409 17 12 0,000 0,03643912 0,06139532 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,03643912 0,06135236 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,03643912 0,06130945 ! carboxylic acid catabolic process GO:0046395 156 98 1,000 0,03702381 0,06224968 GO:0016054|organic acid catabolic process, ! skeletal muscle tissue development GO:0007519 186 99 1,000 0,03771278 0,06336378 GO:0060538|skeletal muscle organ development, ! cell cycle arrest GO:0007050 213 100 1,000 0,03840666 0,06448459 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03941574 0,06613268 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,03941574 0,0660866 ! regulation of chemokine production GO:0032642 18 13 0,000 0,03941574 0,06604058 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,03941574 0,06599462 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,03941574 0,06594872 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,03941574 0,0659029 ! lipid localization GO:0010876 28 13 0,000 0,03941574 0,06585713 GO:0019915|lipid storage, ! organelle fusion GO:0048284 32 13 0,000 0,03941574 0,06581143 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,03941574 0,06576579 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,03941574 0,06572021 ! endocrine pancreas development GO:0031018 22 13 0,000 0,03941574 0,0656747 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,03941574 0,06562925 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,03941574 0,06558386 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,03941574 0,06553854 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03941574 0,06549328 ! methionine metabolic process GO:0006555 27 13 0,000 0,03941574 0,06544808 ! plasma membrane organization GO:0007009 24 13 0,000 0,03941574 0,06540294 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,03941574 0,06535787 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,03941574 0,06531286 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,03941574 0,06526791 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,03941574 0,06522302 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,03941574 0,06517819 ! response to X-ray GO:0010165 25 13 0,000 0,03941574 0,06513342 ! cytokine metabolic process GO:0042107 22 13 0,000 0,03941574 0,06508872 ! exocrine system development GO:0035272 32 13 0,000 0,03941574 0,06504408 ! negative regulation of mitotic cell cycle GO:0045930 33 13 0,000 0,03941574 0,0649995 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,03941574 0,06495498 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,03941574 0,06491052 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,03941574 0,06486612 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,03941574 0,06482178 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,03941574 0,0647775 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,03941574 0,06473329 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,03941574 0,06468913 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,03941574 0,06464503 ! regulation of cellular pH GO:0030641 22 13 0,000 0,03941574 0,064601 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03941574 0,06455702 ! ribosome assembly GO:0042255 17 13 0,000 0,03941574 0,06451311 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,03941574 0,06446925 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,03941574 0,06442545 ! chromatin silencing GO:0006342 26 13 0,000 0,03941574 0,06438171 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,03941574 0,06433804 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03941574 0,06429442 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03941574 0,06425086 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,03941574 0,06420736 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,03941574 0,06416391 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03941574 0,06412053 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,03941574 0,06407721 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,03941574 0,06403394 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,03941574 0,06399073 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,03941574 0,06394758 ! embryonic placenta development GO:0001892 23 13 0,000 0,03941574 0,06390449 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,03941574 0,06386146 ! insulin secretion GO:0030073 23 13 0,000 0,03941574 0,06381848 ! actin filament polymerization GO:0030041 24 13 0,000 0,03941574 0,06377557 ! acrosome reaction GO:0007340 18 13 0,000 0,03941574 0,06373271 ! rRNA transcription GO:0009303 25 14 0,000 0,04238326 0,06848498 ! lactation GO:0007595 26 14 0,000 0,04238326 0,06843901 ! N-terminal protein amino acid modification GO:0031365 27 14 0,000 0,04238326 0,06839311 ! reproductive cellular process GO:0048610 20 14 0,000 0,04238326 0,06834727 ! tRNA modification GO:0006400 20 14 0,000 0,04238326 0,06830149 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,04238326 0,06825578 ! regulation of S phase GO:0033261 23 14 0,000 0,04238326 0,06821012 ! water transport GO:0006833 21 14 0,000 0,04238326 0,06816452 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,04238326 0,06811899 ! non-recombinational repair GO:0000726 25 14 0,000 0,04238326 0,06807352 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,04238326 0,0680281 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,04238326 0,06798275 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,04238326 0,06793746 ! hair follicle morphogenesis GO:0031069 26 14 0,000 0,04238326 0,06789223 ! RNA polyadenylation GO:0043631 30 14 0,000 0,04238326 0,06784706 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,04238326 0,06780195 ! palate development GO:0060021 31 14 0,000 0,04238326 0,0677569 ! regulated secretory pathway GO:0045055 23 14 0,000 0,04238326 0,0677119 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,04238326 0,06766697 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,04238326 0,0676221 ! arginine metabolic process GO:0006525 17 14 0,000 0,04238326 0,06757729 ! regulation of heart rate GO:0002027 24 14 0,000 0,04238326 0,06753254 ! organic alcohol transport GO:0015850 29 14 0,000 0,04238326 0,06748784 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 0,000 0,04238326 0,06744321 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04238326 0,06739863 ! neutral amino acid transport GO:0015804 26 14 0,000 0,04238326 0,06735411 ! L-amino acid transport GO:0015807 30 14 0,000 0,04238326 0,06730966 ! bone mineralization GO:0030282 17 14 0,000 0,04238326 0,06726526 ! stem cell development GO:0048864 43 14 0,000 0,04238326 0,06722092 GO:0019827|stem cell maintenance, ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,04238326 0,06717663 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04238326 0,06713241 ! cerebellum development GO:0021549 21 14 0,000 0,04238326 0,06708824 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,04238326 0,06704413 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,04238326 0,06700008 ! response to gamma radiation GO:0010332 28 14 0,000 0,04238326 0,06695609 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,04238326 0,06691216 ! cofactor transport GO:0051181 26 14 0,000 0,04238326 0,06686828 ! NADP metabolic process GO:0006739 24 14 0,000 0,04238326 0,06682446 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,04238326 0,0667807 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,04238326 0,06673699 ! intestinal absorption GO:0050892 25 14 0,000 0,04238326 0,06669335 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,04238326 0,06664976 ! oxygen transport GO:0015671 21 14 0,000 0,04238326 0,06660622 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04238326 0,06656275 ! male genitalia development GO:0030539 24 14 0,000 0,04238326 0,06651933 ! regulation of axon extension GO:0030516 37 14 0,000 0,04238326 0,06647596 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,04238326 0,06643266 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04534172 0,07102355 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,04534172 0,07097734 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! superoxide anion generation GO:0042554 20 15 0,000 0,04534172 0,07093119 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,04534172 0,0708851 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,04534172 0,07083907 ! copper ion transport GO:0006825 20 15 0,000 0,04534172 0,0707931 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,04534172 0,07074719 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,04534172 0,07070134 ! sulfate transport GO:0008272 23 15 0,000 0,04534172 0,07065555 ! response to cAMP GO:0051591 22 15 0,000 0,04534172 0,07060982 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,04534172 0,07056415 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,04534172 0,07051853 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,04534172 0,07047298 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,04534172 0,07042748 ! response to hexose stimulus GO:0009746 22 15 0,000 0,04534172 0,07038205 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,04534172 0,07033667 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,04534172 0,07029135 ! pituitary gland development GO:0021983 29 15 0,000 0,04534172 0,07024608 ! vesicle coating GO:0006901 33 15 0,000 0,04534172 0,07020088 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,04534172 0,07015574 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,04534172 0,07011065 ! regulation of exocytosis GO:0017157 22 15 0,000 0,04534172 0,07006562 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,04534172 0,07002065 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,04534172 0,06997573 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,04534172 0,06993088 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,04534172 0,06988608 ! regulation of vasodilation GO:0042312 26 15 0,000 0,04534172 0,06984134 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,04534172 0,06979665 ! histone deacetylation GO:0016575 20 15 0,000 0,04534172 0,06975203 ! mRNA splice site selection GO:0006376 38 15 0,000 0,04534172 0,06970746 ! tissue regeneration GO:0042246 26 15 0,000 0,04534172 0,06966294 ! water homeostasis GO:0030104 27 15 0,000 0,04534172 0,06961849 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,04534172 0,06957409 ! muscle maintenance GO:0046716 26 15 0,000 0,04534172 0,06952974 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,04534172 0,06948546 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,04534172 0,06944123 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,04534172 0,06939705 ! heme biosynthetic process GO:0006783 29 15 0,000 0,04534172 0,06935294 ! cell killing GO:0001906 29 15 0,000 0,04534172 0,06930888 ! lymphocyte homeostasis GO:0002260 30 15 0,000 0,04534172 0,06926487 ! detection of bacterium GO:0016045 18 15 0,000 0,04534172 0,06922092 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,04534172 0,06917703 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,04534172 0,06913319 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,04534172 0,0690894 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,04534172 0,06904568 ! peptide hormone processing GO:0016486 23 15 0,000 0,04534172 0,069002 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,04829113 0,07344403 ! G1 phase of mitotic cell cycle GO:0000080 35 16 0,000 0,04829113 0,07339764 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,04829113 0,0733513 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,04829113 0,07330502 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,04829113 0,0732588 ! bone remodeling GO:0046849 27 16 0,000 0,04829113 0,07321264 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,04829113 0,07316653 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,04829113 0,07312049 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,04829113 0,0730745 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,04829113 0,07302857 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,04829113 0,0729827 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,04829113 0,07293688 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,04829113 0,07289113 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,04829113 0,07284543 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,04829113 0,07279978 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,04829113 0,0727542 ! protein polyubiquitination GO:0000209 34 16 0,000 0,04829113 0,07270867 ! glutamate metabolic process GO:0006536 22 16 0,000 0,04829113 0,0726632 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,04829113 0,07261779 ! response to osmotic stress GO:0006970 25 16 0,000 0,04829113 0,07257243 ! negative regulation of microtubule depolymerization GO:0007026 46 16 0,000 0,04829113 0,07252713 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 26 16 0,000 0,04829113 0,07248188 ! fructose metabolic process GO:0006000 25 16 0,000 0,04829113 0,07243669 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04829113 0,07239156 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04829113 0,07234649 ! intermediate filament-based process GO:0045103 32 16 0,000 0,04829113 0,07230147 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,04829113 0,0722565 ! negative regulation of immune response GO:0050777 35 16 0,000 0,04829113 0,0722116 ! axon cargo transport GO:0008088 43 16 0,000 0,04829113 0,07216674 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,04829113 0,07212195 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,04829113 0,07207721 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,04829113 0,07203252 ! DNA replication initiation GO:0006270 27 16 0,000 0,04829113 0,07198789 ! neuron recognition GO:0008038 35 16 0,000 0,04829113 0,07194332 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,04829113 0,0718988 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,04829113 0,07185433 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,04829113 0,07180992 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,04829113 0,07176557 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,04829113 0,07172127 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,04829113 0,07167702 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,04829113 0,07163283 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04829113 0,0715887 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,04829113 0,07154462 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,04829113 0,07150059 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,04829113 0,07145662 ! defense response to virus GO:0051607 37 16 0,000 0,04829113 0,0714127 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,05123153 0,07571441 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,05123153 0,07566793 ! metencephalon development GO:0022037 30 17 0,000 0,05123153 0,07562151 ! negative regulation of cell cycle process GO:0010948 32 17 0,000 0,05123153 0,07557514 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,05123153 0,07552883 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,05123153 0,07548258 ! signal complex assembly GO:0007172 41 17 0,000 0,05123153 0,07543639 ! endothelial cell migration GO:0043542 28 17 0,000 0,05123153 0,07539025 ! inositol metabolic process GO:0006020 28 17 0,000 0,05123153 0,07534417 ! gene silencing by RNA GO:0031047 36 17 0,000 0,05123153 0,07529814 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,05123153 0,07525217 ! glial cell development GO:0021782 27 17 0,000 0,05123153 0,07520626 ! limbic system development GO:0021761 36 17 0,000 0,05123153 0,0751604 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,05123153 0,0751146 ! adult walking behavior GO:0007628 33 17 0,000 0,05123153 0,07506885 ! heart looping GO:0001947 30 17 0,000 0,05123153 0,07502316 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,05123153 0,07497753 ! regulation of viral genome replication GO:0045069 28 17 0,000 0,05123153 0,07493195 ! myoblast differentiation GO:0045445 45 17 0,000 0,05123153 0,07488642 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,05123153 0,07484096 ! regulation of survival gene product expression GO:0045884 33 17 0,000 0,05123153 0,07479554 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,05123153 0,07475018 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,05123153 0,07470488 ! glycine metabolic process GO:0006544 28 17 0,000 0,05123153 0,07465963 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,05123153 0,07461444 ! NAD metabolic process GO:0019674 29 17 0,000 0,05123153 0,0745693 ! membrane budding GO:0006900 37 17 0,000 0,05123153 0,07452422 ! DNA integration GO:0015074 29 17 0,000 0,05123153 0,07447919 ! regulation of protein binding GO:0043393 33 17 0,000 0,05123153 0,07443421 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,05123153 0,07438929 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,05123153 0,07434442 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,05123153 0,07429961 ! genitalia development GO:0048806 30 17 0,000 0,05123153 0,07425485 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 0,000 0,05123153 0,07421015 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,05123153 0,0741655 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,05123153 0,0741209 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,05123153 0,07407636 ! steroid catabolic process GO:0006706 31 17 0,000 0,05123153 0,07403186 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,05123153 0,07398743 ! gas transport GO:0015669 25 17 0,000 0,05123153 0,07394304 ! organic cation transport GO:0015695 31 17 0,000 0,05123153 0,07389871 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,05123153 0,07385444 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,05123153 0,07381021 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,05123153 0,07376604 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 0,000 0,05123153 0,07372192 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,05416294 0,07789362 ! neuron maturation GO:0042551 42 18 0,000 0,05416294 0,07784709 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,05416294 0,07780061 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,05416294 0,07775419 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,05416294 0,07770783 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,05416294 0,07766152 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,05416294 0,07761526 ! patterning of blood vessels GO:0001569 39 18 0,000 0,05416294 0,07756907 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,05416294 0,07752292 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,05416294 0,07747683 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,05416294 0,0774308 ! epidermis morphogenesis GO:0048730 40 18 0,000 0,05416294 0,07738482 ! glutamine metabolic process GO:0006541 29 18 0,000 0,05416294 0,07733889 ! response to retinoic acid GO:0032526 26 18 0,000 0,05416294 0,07729302 ! cell-substrate junction assembly GO:0007044 54 18 0,000 0,05416294 0,0772472 ! peptidyl-serine phosphorylation GO:0018105 38 18 0,000 0,05416294 0,07720144 ! response to fungus GO:0009620 21 18 0,000 0,05416294 0,07715573 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,05416294 0,07711008 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,05416294 0,07706448 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,05416294 0,07701893 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,05416294 0,07697344 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,05416294 0,076928 ! vitamin transport GO:0051180 27 18 0,000 0,05416294 0,07688261 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,05416294 0,07683728 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,05416294 0,076792 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,05416294 0,07674678 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,05416294 0,07670161 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,05416294 0,07665649 ! nerve development GO:0021675 28 18 0,000 0,05416294 0,07661142 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,05416294 0,07656641 ! protein secretion GO:0009306 39 19 0,000 0,05708539 0,08065029 ! positive regulation of translation GO:0045727 30 19 0,000 0,05708539 0,08060296 ! negative regulation of defense response GO:0031348 25 19 0,000 0,05708539 0,08055569 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,05708539 0,08050847 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,05708539 0,0804613 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05708539 0,0804142 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,05708539 0,08036714 ! bile acid metabolic process GO:0008206 29 19 0,000 0,05708539 0,08032014 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,05708539 0,0802732 ! cerebral cortex development GO:0021987 36 19 0,000 0,05708539 0,08022631 ! pigmentation during development GO:0048066 41 19 0,000 0,05708539 0,08017948 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,05708539 0,0801327 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,05708539 0,08008597 ! heme metabolic process GO:0042168 36 19 0,000 0,05708539 0,0800393 ! actin filament bundle formation GO:0051017 42 19 0,000 0,05708539 0,07999269 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,05708539 0,07994613 ! plasma membrane fusion GO:0045026 28 19 0,000 0,05708539 0,07989962 ! peptide cross-linking GO:0018149 37 19 0,000 0,05708539 0,07985317 ! protein export from nucleus GO:0006611 36 19 0,000 0,05708539 0,07980677 ! heart process GO:0003015 30 19 0,000 0,05708539 0,07976042 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,05708539 0,07971413 ! cellular pigmentation GO:0033059 36 19 0,000 0,05708539 0,07966789 ! G1 phase GO:0051318 40 19 0,000 0,05708539 0,07962171 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,05708539 0,07957558 ! cell-cell junction organization GO:0045216 35 19 0,000 0,05708539 0,0795295 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,05708539 0,07948348 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,05708539 0,0794375 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,05708539 0,07939159 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,05708539 0,07934572 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,05708539 0,07929991 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,05708539 0,07925415 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,05708539 0,07920845 ! cilium assembly GO:0042384 37 19 0,000 0,05708539 0,07916279 ! peptide hormone secretion GO:0030072 31 19 0,000 0,05708539 0,07911719 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,05999891 0,08310729 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,05999891 0,08305948 ! positive regulation of ossification GO:0045778 47 20 0,000 0,05999891 0,08301171 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,05999891 0,08296401 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,05999891 0,08291635 ! protein amino acid acetylation GO:0006473 39 20 0,000 0,05999891 0,08286875 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 0,000 0,05999891 0,08282121 ! cAMP metabolic process GO:0046058 36 20 0,000 0,05999891 0,08277372 ! response to vitamin GO:0033273 31 20 0,000 0,05999891 0,08272629 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,05999891 0,08267891 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,05999891 0,08263158 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,05999891 0,08258431 ! response to alkaloid GO:0043279 38 20 0,000 0,05999891 0,08253709 ! retinoid metabolic process GO:0001523 32 20 0,000 0,05999891 0,08248993 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,05999891 0,08244282 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,05999891 0,08239576 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,05999891 0,08234876 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,05999891 0,08230181 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 0,000 0,05999891 0,08225491 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,05999891 0,08220807 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,05999891 0,08216128 ! body fluid secretion GO:0007589 31 20 0,000 0,05999891 0,08211454 ! peptide secretion GO:0002790 35 20 0,000 0,05999891 0,08206786 ! stem cell differentiation GO:0048863 53 20 0,000 0,05999891 0,08202123 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,05999891 0,08197466 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,05999891 0,08192813 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,05999891 0,08188166 ! sensory perception of pain GO:0019233 30 20 0,000 0,05999891 0,08183524 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,05999891 0,08178888 ! diencephalon development GO:0021536 34 20 0,000 0,05999891 0,08174257 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,05999891 0,0816963 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,05999891 0,0816501 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,05999891 0,08160394 ! peptidyl-serine modification GO:0018209 43 20 0,000 0,05999891 0,08155784 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,05999891 0,08151178 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,05999891 0,08146578 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,05999891 0,08141984 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,05999891 0,08137394 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,05999891 0,0813281 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,05999891 0,0812823 ! actin filament-based movement GO:0030048 43 20 0,000 0,05999891 0,08123656 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,05999891 0,08119087 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,05999891 0,08114523 ! negative regulation of translation GO:0017148 29 20 0,000 0,05999891 0,08109965 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,05999891 0,08105411 ! regulation of cell killing GO:0031341 42 21 0,000 0,06290352 0,08493034 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,06290352 0,08488271 ! hormone secretion GO:0046879 38 21 0,000 0,06290352 0,08483513 ! glycerol metabolic process GO:0006071 34 21 0,000 0,06290352 0,0847876 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,06290352 0,08474013 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,06290352 0,08469271 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,06290352 0,08464534 ! ovarian follicle development GO:0001541 35 21 0,000 0,06290352 0,08459802 ! smooth muscle contraction GO:0006939 46 21 0,000 0,06290352 0,08455076 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,06290352 0,08450355 ! cell structure disassembly during apoptosis GO:0006921 30 21 0,000 0,06290352 0,0844564 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,06290352 0,08440929 ! cell aging GO:0007569 44 21 0,000 0,06290352 0,08436224 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,06290352 0,08431525 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,06290352 0,0842683 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,06290352 0,08422141 ! cytolysis GO:0019835 24 21 0,000 0,06290352 0,08417456 ! vasodilation GO:0042311 39 21 0,000 0,06290352 0,08412777 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,06290352 0,08408104 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,06290352 0,08403435 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,06290352 0,08398772 ! oogenesis GO:0048477 36 21 0,000 0,06290352 0,08394113 ! DNA modification GO:0006304 34 21 0,000 0,06290352 0,0838946 ! collagen fibril organization GO:0030199 59 21 0,000 0,06290352 0,08384813 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,06290352 0,0838017 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,06290352 0,08375532 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,06290352 0,083709 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,06290352 0,08366272 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,06290352 0,0836165 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,06290352 0,08357033 ! collagen catabolic process GO:0030574 28 21 0,000 0,06290352 0,08352421 ! sperm-egg recognition GO:0035036 21 21 0,000 0,06290352 0,08347814 ! gut development GO:0048565 39 21 0,000 0,06290352 0,08343212 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,06579925 0,08722479 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,06579925 0,08717676 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,06579925 0,08712878 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,06579925 0,08708086 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,06579925 0,08703298 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,06579925 0,08698516 ! regeneration GO:0031099 41 22 0,000 0,06579925 0,0869374 ! keratinization GO:0031424 28 22 0,000 0,06579925 0,08688968 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,06579925 0,08684202 ! sensory perception of taste GO:0050909 28 22 0,000 0,06579925 0,08679441 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 0,000 0,06579925 0,08674685 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,06579925 0,08669934 ! vacuolar transport GO:0007034 36 22 0,000 0,06579925 0,08665189 ! lysosome organization GO:0007040 41 22 0,000 0,06579925 0,08660449 ! central nervous system neuron development GO:0021954 46 22 0,000 0,06579925 0,08655713 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,06579925 0,08650984 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,06579925 0,08646259 ! fucose metabolic process GO:0006004 39 22 0,000 0,06579925 0,08641539 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,06579925 0,08636825 ! apoptotic nuclear changes GO:0030262 32 22 0,000 0,06579925 0,08632116 ! ureteric bud development GO:0001657 43 22 0,000 0,06579925 0,08627411 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,06579925 0,08622712 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,06579925 0,08618018 ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,06579925 0,0861333 ! positive regulation of intracellular transport GO:0032388 37 22 0,000 0,06579925 0,08608646 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,06579925 0,08603967 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,06579925 0,08599294 ! sarcomere organization GO:0045214 30 22 0,000 0,06579925 0,08594625 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,06579925 0,08589962 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,06579925 0,08585304 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,06579925 0,0858065 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 0,000 0,06579925 0,08576002 ! protein stabilization GO:0050821 39 22 0,000 0,06579925 0,08571359 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,06868613 0,08942578 ! gluconeogenesis GO:0006094 33 23 0,000 0,06868613 0,08937741 ! viral genome replication GO:0019079 41 23 0,000 0,06868613 0,0893291 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,06868613 0,08928084 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,06868613 0,08923263 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,06868613 0,08918448 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,06868613 0,08913637 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,06868613 0,08908832 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,06868613 0,08904032 ! regulation of cell-matrix adhesion GO:0001952 78 23 0,000 0,06868613 0,08899237 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 48 23 0,000 0,06868613 0,08894447 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,06868613 0,08889663 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! activation of pro-apoptotic gene products GO:0008633 47 23 0,000 0,06868613 0,08884884 ! peroxisome organization GO:0007031 37 23 0,000 0,06868613 0,08880109 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,06868613 0,0887534 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,06868613 0,08870576 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,06868613 0,08865817 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,06868613 0,08861063 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,06868613 0,08856315 ! regulation of viral reproduction GO:0050792 38 23 0,000 0,06868613 0,08851571 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,06868613 0,08846833 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,06868613 0,08842099 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,06868613 0,08837371 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,06868613 0,08832647 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,06868613 0,08827929 ! fatty acid transport GO:0015908 44 23 0,000 0,06868613 0,08823216 ! platelet activation GO:0030168 37 23 0,000 0,06868613 0,08818508 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,06868613 0,08813804 ! hormone transport GO:0009914 40 23 0,000 0,06868613 0,08809106 ! cell-cell recognition GO:0009988 25 23 0,000 0,06868613 0,08804413 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,06868613 0,08799725 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,06868613 0,08795042 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,06868613 0,08790363 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,06868613 0,0878569 ! protein import into nucleus, translocation GO:0000060 46 24 0,000 0,07156419 0,0914896 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 0,000 0,07156419 0,09144102 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,07156419 0,09139248 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,07156419 0,091344 ! vesicle docking GO:0048278 47 24 0,000 0,07156419 0,09129556 ! spinal cord development GO:0021510 47 24 0,000 0,07156419 0,09124718 ! vacuole organization GO:0007033 43 24 0,000 0,07156419 0,09119885 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,07156419 0,09115057 ! digestive system process GO:0022600 39 24 0,000 0,07156419 0,09110235 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,07156419 0,09105417 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,07156419 0,09100604 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,07156419 0,09095797 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,07156419 0,09090994 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,07156419 0,09086197 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,07156419 0,09081405 ! pallium development GO:0021543 49 24 0,000 0,07156419 0,09076617 ! pentose metabolic process GO:0019321 35 24 0,000 0,07156419 0,09071835 ! leukocyte homeostasis GO:0001776 44 24 0,000 0,07156419 0,09067058 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,07156419 0,09062286 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,07156419 0,09057519 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,07156419 0,09052757 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,07156419 0,09048 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,07156419 0,09043248 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,07156419 0,090385 ! regulation of amine transport GO:0051952 40 24 0,000 0,07156419 0,09033758 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,07443344 0,09391026 ! phototransduction GO:0007602 33 25 0,000 0,07443344 0,09386104 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,07443344 0,09381187 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,07443344 0,09376276 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,07443344 0,09371369 ! negative regulation of DNA replication GO:0008156 42 25 0,000 0,07443344 0,09366468 ! receptor metabolic process GO:0043112 46 25 0,000 0,07443344 0,09361572 ! response to starvation GO:0042594 42 25 0,000 0,07443344 0,0935668 ! osteoblast differentiation GO:0001649 60 25 0,000 0,07443344 0,09351794 ! response to endoplasmic reticulum stress GO:0034976 43 25 0,000 0,07443344 0,09346914 ! neural crest cell development GO:0014032 54 25 0,000 0,07443344 0,09342038 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,07443344 0,09337167 ! negative regulation of cell development GO:0010721 73 25 0,000 0,07443344 0,09332301 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,07443344 0,09327441 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,07443344 0,09322585 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! somitogenesis GO:0001756 43 25 0,000 0,07443344 0,09317735 ! immunoglobulin production GO:0002377 55 25 0,000 0,07443344 0,09312889 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,07443344 0,09308049 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,07443344 0,09303214 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,07443344 0,09298383 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,07443344 0,09293558 ! telomere organization GO:0032200 43 25 0,000 0,07443344 0,09288738 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,07443344 0,09283922 GO:0060606|tube closure, ! liver development GO:0001889 53 25 0,000 0,07443344 0,09279112 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,07729393 0,09630719 ! embryonic pattern specification GO:0009880 44 26 0,000 0,07729393 0,09625734 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,07729393 0,09620755 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,07729393 0,0961578 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,07729393 0,09610811 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,07729393 0,09605847 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,07729393 0,09600887 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,07729393 0,09595933 ! molting cycle process GO:0022404 50 26 0,000 0,07729393 0,09590985 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! tube lumen formation GO:0035148 50 26 0,000 0,07729393 0,09586041 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,07729393 0,09581102 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,07729393 0,09576168 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,07729393 0,0957124 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,07729393 0,09566316 ! cellular response to oxidative stress GO:0034599 39 26 0,000 0,07729393 0,09561398 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,07729393 0,09556485 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,07729393 0,09551576 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,07729393 0,09546673 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,07729393 0,09541775 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,07729393 0,09536882 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,07729393 0,09531993 ! blastocyst development GO:0001824 49 26 0,000 0,07729393 0,0952711 ! leukocyte proliferation GO:0070661 52 26 0,000 0,07729393 0,09522232 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,07729393 0,09517359 ! neuron fate commitment GO:0048663 48 27 0,000 0,08014567 0,09863451 ! iron ion transport GO:0006826 59 27 0,000 0,08014567 0,09858409 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,08014567 0,09853371 ! protein amino acid acylation GO:0043543 55 27 0,000 0,08014567 0,09848339 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,08014567 0,09843312 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,08014567 0,09838289 ! fat cell differentiation GO:0045444 50 27 0,000 0,08014567 0,09833272 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,08014567 0,09828261 ! mitochondrial membrane organization GO:0007006 57 27 0,000 0,08014567 0,09823254 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,08014567 0,09818252 ! autophagy GO:0006914 41 27 0,000 0,08014567 0,09813256 ! male gonad development GO:0008584 44 27 0,000 0,08014567 0,09808264 ! response to toxin GO:0009636 47 27 0,000 0,08014567 0,09803278 ! primary neural tube formation GO:0014020 51 27 0,000 0,08014567 0,09798296 ! base-excision repair GO:0006284 41 27 0,000 0,08014567 0,0979332 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,08014567 0,09788349 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,08014567 0,09783383 ! regulation of chromosome organization GO:0033044 42 27 0,000 0,08014567 0,09778422 ! glutathione metabolic process GO:0006749 39 27 0,000 0,08014567 0,09773465 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,08014567 0,09768514 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,08014567 0,09763568 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,08014567 0,09758627 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,08298869 0,10099685 ! circadian rhythm GO:0007623 50 28 0,000 0,08298869 0,10094579 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,08298869 0,10089478 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 59 28 0,000 0,08298869 0,10084383 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,08298869 0,10079292 ! ER-nuclear signaling pathway GO:0006984 48 28 0,000 0,08298869 0,10074207 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,08298869 0,10069126 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,08298869 0,10064051 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,08298869 0,10058981 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,08298869 0,10053916 ! synaptogenesis GO:0007416 42 28 0,000 0,08298869 0,10048856 ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,08298869 0,10043802 ! translational initiation GO:0006413 65 29 0,000 0,08582301 0,10381607 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,08582301 0,1037639 ! regulation of pH GO:0006885 43 29 0,000 0,08582301 0,10371179 ! cellular iron ion homeostasis GO:0006879 51 29 0,000 0,08582301 0,10365972 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,08582301 0,10360771 ! complement activation, classical pathway GO:0006958 48 29 0,000 0,08582301 0,10355575 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,08582301 0,10350384 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,08582301 0,10345199 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,08582301 0,10340018 ! response to organic cyclic substance GO:0014070 55 29 0,000 0,08582301 0,10334843 ! cell fate determination GO:0001709 60 29 0,000 0,08582301 0,10329673 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,08582301 0,10324508 ! detection of light stimulus GO:0009583 38 29 0,000 0,08582301 0,10319349 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 0,000 0,08582301 0,10314194 ! negative regulation of neuron apoptosis GO:0043524 56 29 0,000 0,08582301 0,10309045 ! tissue homeostasis GO:0001894 48 29 0,000 0,08582301 0,10303901 GO:0048871|multicellular organismal homeostasis, ! zinc ion transport GO:0006829 45 30 0,000 0,08864867 0,10637841 ! membrane docking GO:0022406 61 30 0,000 0,08864867 0,10632538 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,08864867 0,1062724 ! cell junction assembly GO:0034329 78 30 0,000 0,08864867 0,10621947 ! regulation of innate immune response GO:0045088 51 30 0,000 0,08864867 0,1061666 ! myofibril assembly GO:0030239 47 30 0,000 0,08864867 0,10611378 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,08864867 0,10606102 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,08864867 0,1060083 ! phospholipid transport GO:0015914 51 30 0,000 0,08864867 0,10595564 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,08864867 0,10590303 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,08864867 0,10585047 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,08864867 0,10579797 ! eye morphogenesis GO:0048592 60 30 0,000 0,08864867 0,10574552 ! response to heat GO:0009408 50 30 0,000 0,08864867 0,10569311 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,09146569 0,10899775 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,09146569 0,10894379 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,09146569 0,10888988 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,09146569 0,10883603 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,09146569 0,10878223 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,09146569 0,10872849 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,09146569 0,10867479 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,09146569 0,10862115 ! ovulation cycle process GO:0022602 49 31 0,000 0,09146569 0,10856757 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,09146569 0,10851403 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,09146569 0,10846055 ! peptide transport GO:0015833 55 31 0,000 0,09146569 0,10840712 ! iron ion homeostasis GO:0055072 54 31 0,000 0,09146569 0,10835374 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,09146569 0,10830042 ! mesoderm formation GO:0001707 69 31 0,000 0,09146569 0,10824715 ! natural killer cell activation GO:0030101 45 31 0,000 0,09146569 0,10819393 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,09146569 0,10814076 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,09146569 0,10808765 ! negative regulation of transcription regulator activity GO:0090048 58 31 0,000 0,09146569 0,10803459 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,09146569 0,10798158 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,0942741 0,11124251 ! response to hydrogen peroxide GO:0042542 50 32 0,000 0,0942741 0,11118798 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,0942741 0,1111335 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,0942741 0,11107908 ! cholesterol transport GO:0030301 56 32 0,000 0,0942741 0,11102471 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,0942741 0,11097039 ! spliceosome assembly GO:0000245 67 32 0,000 0,0942741 0,11091613 ! spindle organization GO:0007051 46 32 0,000 0,0942741 0,11086192 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,0942741 0,11080776 ! metanephros development GO:0001656 74 32 0,000 0,0942741 0,11075365 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,0942741 0,1106996 ! response to ionizing radiation GO:0010212 65 32 0,000 0,0942741 0,1106456 ! response to mechanical stimulus GO:0009612 57 32 0,000 0,0942741 0,11059165 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,0942741 0,11053776 ! muscle cell development GO:0055001 49 32 0,000 0,0942741 0,11048392 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,0942741 0,11043013 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,0942741 0,11037639 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,0942741 0,1103227 ! ovulation cycle GO:0042698 51 32 0,000 0,0942741 0,11026907 ! BMP signaling pathway GO:0030509 64 32 0,000 0,0942741 0,11021549 ! hindbrain development GO:0030902 61 32 0,000 0,0942741 0,11016196 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,0942741 0,11010848 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,0942741 0,11005506 ! gene silencing GO:0016458 65 32 0,000 0,0942741 0,11000169 ! post-embryonic development GO:0009791 69 33 0,000 0,09707391 0,11321369 ! positive regulation of gene-specific transcription GO:0043193 65 33 0,000 0,09707391 0,11315884 ! protein targeting to membrane GO:0006612 68 33 0,000 0,09707391 0,11310404 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,09707391 0,11304929 ! ceramide metabolic process GO:0006672 64 33 0,000 0,09707391 0,1129946 ! formation of primary germ layer GO:0001704 72 33 0,000 0,09707391 0,11293996 ! cell fate specification GO:0001708 52 33 0,000 0,09707391 0,11288537 ! sterol transport GO:0015918 57 33 0,000 0,09707391 0,11283084 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,09707391 0,11277636 ! adult locomotory behavior GO:0008344 59 33 0,000 0,09707391 0,11272193 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,09707391 0,11266755 ! glial cell differentiation GO:0010001 63 34 0,000 0,09986517 0,1158513 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,09986517 0,11579547 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,09986517 0,11573969 ! regulation of striated muscle tissue development GO:0016202 69 34 0,000 0,09986517 0,11568397 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,09986517 0,1156283 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,09986517 0,11557268 ! spermatid development GO:0007286 63 34 0,000 0,09986517 0,11551712 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,09986517 0,1154616 ! placenta development GO:0001890 53 34 0,000 0,09986517 0,11540615 ! regulation of muscle development GO:0048634 70 35 0,000 0,10264789 0,11856496 ! negative regulation of DNA metabolic process GO:0051053 61 35 0,000 0,10264789 0,11850807 ! negative regulation of cell adhesion GO:0007162 81 35 0,000 0,10264789 0,11845123 ! odontogenesis GO:0042476 66 35 0,000 0,10264789 0,11839445 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,10264789 0,11833772 ! female gonad development GO:0008585 58 35 0,000 0,10264789 0,11828104 ! telencephalon development GO:0021537 68 35 0,000 0,10264789 0,11822442 ! cytokine production GO:0001816 59 35 0,000 0,10264789 0,11816786 ! regulation of microtubule-based process GO:0032886 78 35 0,000 0,10264789 0,11811134 ! neural tube formation GO:0001841 67 35 0,000 0,10264789 0,11805489 ! vesicle localization GO:0051648 64 35 0,000 0,10264789 0,11799848 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,1054221 0,12112969 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,1054221 0,12107187 ! cell junction organization GO:0034330 86 36 0,000 0,1054221 0,12101411 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,1054221 0,1209564 ! positive regulation of cell development GO:0010720 80 36 0,000 0,1054221 0,12089875 ! aerobic respiration GO:0009060 55 36 0,000 0,1054221 0,12084115 ! androgen receptor signaling pathway GO:0030521 74 36 0,000 0,1054221 0,1207836 ! embryonic organ development GO:0048568 57 36 0,000 0,1054221 0,12072612 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,1054221 0,12066868 ! RNA export from nucleus GO:0006405 56 37 0,000 0,10818782 0,12377551 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,10818782 0,12371668 ! actomyosin structure organization GO:0031032 62 37 0,000 0,10818782 0,12365791 ! organic anion transport GO:0015711 68 37 0,000 0,10818782 0,12359919 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,10818782 0,12354053 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,10818782 0,12348193 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,10818782 0,12342338 GO:0015986|ATP synthesis coupled proton transport, ! regulation of protein stability GO:0031647 73 37 0,000 0,10818782 0,12336488 ! glycogen metabolic process GO:0005977 61 37 0,000 0,10818782 0,12330644 ! pigment metabolic process GO:0042440 80 37 0,000 0,10818782 0,12324806 ! spermatid differentiation GO:0048515 66 37 0,000 0,10818782 0,12318973 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,11094509 0,12626957 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,11094509 0,12620987 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,11094509 0,12615023 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,11094509 0,12609064 ! mitotic cell cycle checkpoint GO:0007093 76 38 0,000 0,11094509 0,1260311 ! development of primary female sexual characteristics GO:0046545 67 38 0,000 0,11094509 0,12597163 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 67 38 0,000 0,11094509 0,12591221 ! lipid homeostasis GO:0055088 67 38 0,000 0,11094509 0,12585284 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,11094509 0,12579353 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,11094509 0,12573428 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,11094509 0,12567508 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,11094509 0,12561594 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,11094509 0,12555686 ! glucan metabolic process GO:0044042 62 38 0,000 0,11094509 0,12549783 GO:0006073|cellular glucan metabolic process, ! mRNA catabolic process GO:0006402 71 39 0,000 0,11369392 0,12854679 ! ear morphogenesis GO:0042471 60 39 0,000 0,11369392 0,12848641 ! development of primary male sexual characteristics GO:0046546 66 39 0,000 0,11369392 0,12842609 ! segmentation GO:0035282 67 39 0,000 0,11369392 0,12836582 ! ion transmembrane transport GO:0034220 66 39 0,000 0,11369392 0,12830561 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,11369392 0,12824546 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,11369392 0,12818536 ! RNA modification GO:0009451 57 39 0,000 0,11369392 0,12812532 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,11369392 0,12806534 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,11643434 0,13109079 ! feeding behavior GO:0007631 59 40 0,000 0,11643434 0,13102948 ! mesenchymal cell development GO:0014031 87 40 0,000 0,11643434 0,13096822 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,11643434 0,13090702 ! cytokinesis GO:0000910 72 40 0,000 0,11643434 0,13084588 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,11916638 0,13385356 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,11916638 0,1337911 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,11916638 0,13372869 ! gliogenesis GO:0042063 88 41 0,000 0,11916638 0,13366635 ! T cell differentiation GO:0030217 81 41 0,000 0,11916638 0,13360406 ! female gamete generation GO:0007292 61 41 0,000 0,11916638 0,13354183 ! polyol metabolic process GO:0019751 66 41 0,000 0,11916638 0,13347966 ! positive regulation of transcription factor activity GO:0051091 62 42 0,000 0,12189007 0,13646696 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 67 42 0,000 0,12189007 0,13640349 ! negative regulation of protein complex disassembly GO:0043242 101 42 0,000 0,12189007 0,13634008 ! regulation of tube size GO:0035150 71 42 0,000 0,12189007 0,13627672 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,12189007 0,13621342 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,12189007 0,13615019 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,12189007 0,13608701 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,12189007 0,13602389 ! neuron migration GO:0001764 79 42 0,000 0,12189007 0,13596083 ! regulation of protein secretion GO:0050708 71 42 0,000 0,12189007 0,13589782 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,12189007 0,13583488 ! epithelial cell differentiation GO:0030855 79 43 0,000 0,12460542 0,13879659 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,12460542 0,13873237 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,12460542 0,1386682 ! energy reserve metabolic process GO:0006112 74 43 0,000 0,12460542 0,13860409 ! glucose transport GO:0015758 65 43 0,000 0,12460542 0,13854004 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,12460542 0,13847605 ! neural tube development GO:0021915 77 43 0,000 0,12460542 0,13841212 ! striated muscle contraction GO:0006941 77 43 0,000 0,12460542 0,13834824 ! phagocytosis GO:0006909 90 43 0,000 0,12460542 0,13828443 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,12460542 0,13822067 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,12731247 0,14115843 ! hexose transport GO:0008645 67 44 0,000 0,12731247 0,14109341 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,12731247 0,14102845 ! male sex differentiation GO:0046661 76 44 0,000 0,12731247 0,14096355 ! double-strand break repair GO:0006302 81 44 0,000 0,12731247 0,14089871 ! biopolymer methylation GO:0043414 84 44 0,000 0,12731247 0,14083393 ! B cell differentiation GO:0030183 107 44 0,000 0,12731247 0,14076921 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,12731247 0,14070454 ! developmental growth GO:0048589 82 44 0,000 0,12731247 0,14063994 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,13001123 0,14355531 ! glycolysis GO:0006096 65 45 0,000 0,13001123 0,14348946 ! detection of stimulus involved in sensory perception GO:0050906 66 45 0,000 0,13001123 0,14342367 ! branching morphogenesis of a tube GO:0048754 97 45 0,000 0,13001123 0,14335794 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,13001123 0,14329227 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,13001123 0,14322666 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,13001123 0,14316111 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,13001123 0,14309562 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,13270174 0,14599012 ! pigmentation GO:0043473 100 46 0,000 0,13270174 0,14592339 ! positive regulation of protein transport GO:0051222 72 46 0,000 0,13270174 0,14585673 ! response to calcium ion GO:0051592 81 47 0,000 0,13538402 0,14873696 ! endosome transport GO:0016197 108 47 0,000 0,13538402 0,14866907 ! positive regulation of DNA binding GO:0043388 73 47 0,000 0,13538402 0,14860125 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,13538402 0,14853349 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,13538402 0,14846579 ! methylation GO:0032259 90 47 0,000 0,13538402 0,14839815 ! protein homooligomerization GO:0051260 76 47 0,000 0,13538402 0,14833057 ! mitochondrial transport GO:0006839 82 48 0,000 0,13805809 0,15119151 ! Notch signaling pathway GO:0007219 96 48 0,000 0,13805809 0,15112273 ! cellular component disassembly GO:0022411 86 48 0,000 0,13805809 0,151054 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,13805809 0,15098534 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,13805809 0,15091674 ! activation of caspase activity GO:0006919 84 48 0,000 0,13805809 0,15084821 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,13805809 0,15077973 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,14072397 0,15362154 ! regulation of protein complex disassembly GO:0043244 113 49 0,000 0,14072397 0,15355187 ! regulation of ion transport GO:0043269 77 49 0,000 0,14072397 0,15348227 ! response to temperature stimulus GO:0009266 76 49 0,000 0,14072397 0,15341272 ! endocrine system development GO:0035270 104 49 0,000 0,14072397 0,15334324 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,14072397 0,15327383 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,14072397 0,15320447 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,14072397 0,15313518 ! detection of abiotic stimulus GO:0009582 74 49 0,000 0,14072397 0,15306595 ! inner ear development GO:0048839 79 50 0,000 0,14338171 0,1558863 ! histone modification GO:0016570 91 50 0,000 0,14338171 0,15581589 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,14338171 0,15574555 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,14338171 0,15567526 ! positive regulation of binding GO:0051099 78 51 0,000 0,1460313 0,15848052 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,1460313 0,15840907 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,1460313 0,15833768 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,1460313 0,15826636 ! excretion GO:0007588 83 51 0,000 0,1460313 0,1581951 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,1460313 0,15812391 ! chromatin remodeling GO:0006338 109 51 0,000 0,1460313 0,15805277 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,1460313 0,15798171 ! vesicle organization GO:0016050 107 51 0,000 0,1460313 0,1579107 ! epithelial tube morphogenesis GO:0060562 98 51 0,000 0,1460313 0,15783977 ! membrane fusion GO:0006944 110 52 0,000 0,1486728 0,1606227 ! covalent chromatin modification GO:0016569 101 52 0,000 0,1486728 0,1605506 ! morphogenesis of a branching structure GO:0001763 111 52 0,000 0,1486728 0,16047858 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,1513062 0,16324786 ! RNA catabolic process GO:0006401 93 53 0,000 0,1513062 0,16317469 ! regulation of translational initiation GO:0006446 82 53 0,000 0,1513062 0,16310158 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,1513062 0,16302854 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,1513062 0,16295556 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,1513062 0,16288265 ! cell maturation GO:0048469 100 53 0,000 0,1513062 0,16280981 ! regulation of neuron apoptosis GO:0043523 100 53 0,000 0,1513062 0,16273703 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,1513062 0,16266431 ! negative regulation of cytoskeleton organization GO:0051494 124 54 0,000 0,15393155 0,16541283 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,15393155 0,16533898 ! cell recognition GO:0008037 85 54 0,000 0,15393155 0,1652652 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,15393155 0,16519149 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,15393155 0,16511784 ! chloride transport GO:0006821 90 55 0,000 0,15654887 0,16785053 ! positive regulation of caspase activity GO:0043280 95 55 0,000 0,15654887 0,16777576 GO:0010952|positive regulation of peptidase activity, ! glucose catabolic process GO:0006007 82 55 0,000 0,15654887 0,16770106 ! cellular polysaccharide metabolic process GO:0044264 86 55 0,000 0,15654887 0,16762643 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,15654887 0,16755186 ! aging GO:0007568 103 55 0,000 0,15654887 0,16747736 ! gastrulation GO:0007369 112 55 0,000 0,15654887 0,16740293 ! RNA elongation GO:0006354 79 55 0,000 0,15654887 0,16732856 ! nuclear export GO:0051168 97 55 0,000 0,15654887 0,16725426 ! regulation of actin filament length GO:0030832 105 56 0,000 0,15915818 0,16996652 ! sensory perception of smell GO:0007608 80 56 0,000 0,15915818 0,16989111 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,15915818 0,16981577 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,15915818 0,1697405 ! proton transport GO:0015992 94 56 0,000 0,15915818 0,1696653 ! positive regulation of organelle organization GO:0010638 100 56 0,000 0,15915818 0,16959016 ! hydrogen transport GO:0006818 97 58 0,000 0,16435286 0,1750478 ! adult behavior GO:0030534 99 58 0,000 0,16435286 0,17497034 ! regulation of cellular component size GO:0032535 109 59 0,000 0,16693828 0,17764418 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,16693828 0,17756565 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,16693828 0,17748718 ! DNA catabolic process GO:0006308 86 59 0,000 0,16693828 0,17740879 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,16951579 0,18006842 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,16951579 0,17998896 ! camera-type eye development GO:0043010 116 60 0,000 0,16951579 0,17990956 ! kidney development GO:0001822 122 60 0,000 0,16951579 0,17983024 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,1720854 0,18247575 ! mesoderm development GO:0007498 119 61 0,000 0,1720854 0,18239537 ! tRNA processing GO:0008033 89 61 0,000 0,1720854 0,18231505 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,1720854 0,18223481 ! ear development GO:0043583 103 62 0,000 0,17464716 0,18486628 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,17464716 0,18478499 ! gonad development GO:0008406 98 62 0,000 0,17464716 0,18470376 ! regulation of mitosis GO:0007088 105 63 0,000 0,17720107 0,1873224 GO:0051783|regulation of nuclear division, ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,17720107 0,18724013 ! detection of external stimulus GO:0009581 91 63 0,000 0,17720107 0,18715793 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,17720107 0,18707581 ! steroid hormone receptor signaling pathway GO:0030518 129 63 0,000 0,17720107 0,18699376 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,17974716 0,1895974 ! cell redox homeostasis GO:0045454 102 64 0,000 0,17974716 0,18951432 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,17974716 0,18943131 ! single fertilization GO:0007338 75 64 0,000 0,17974716 0,18934837 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,18228546 0,19193822 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,18228546 0,19185425 ! embryonic limb morphogenesis GO:0030326 125 65 0,000 0,18228546 0,19177036 GO:0035113|embryonic appendage morphogenesis, ! germ cell development GO:0007281 118 65 0,000 0,18228546 0,19168655 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,18481599 0,19426268 ! actin filament organization GO:0007015 148 66 0,000 0,18481599 0,19417785 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,18481599 0,19409309 ! extracellular matrix organization GO:0030198 133 66 0,000 0,18481599 0,19400841 ! secondary metabolic process GO:0019748 116 66 0,000 0,18481599 0,1939238 ! developmental maturation GO:0021700 116 66 0,000 0,18481599 0,19383927 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,18733877 0,1963996 ! homeostasis of number of cells GO:0048872 114 67 0,000 0,18733877 0,19631406 ! hexose catabolic process GO:0019320 104 67 0,000 0,18733877 0,1962286 ! positive regulation of T cell activation GO:0050870 109 67 0,000 0,18733877 0,19614321 ! activation of immune response GO:0002253 105 67 0,000 0,18733877 0,19605789 ! amino acid transport GO:0006865 125 68 0,000 0,18985383 0,19860362 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,18985383 0,1985173 ! negative regulation of ligase activity GO:0051352 112 68 0,000 0,18985383 0,19843107 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 0,000 0,18985383 0,19834491 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,18985383 0,19825882 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,18985383 0,19817281 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,19236119 0,20070296 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,19236119 0,20061596 ! urogenital system development GO:0001655 137 69 0,000 0,19236119 0,20052904 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,19236119 0,20044219 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,19236119 0,20035542 ! antigen processing and presentation GO:0019882 104 69 0,000 0,19236119 0,20026872 ! appendage morphogenesis GO:0035107 135 70 0,000 0,19486087 0,20278341 GO:0035108|limb morphogenesis, ! amine catabolic process GO:0009310 117 71 0,000 0,1973529 0,20528797 ! reproductive structure development GO:0048608 113 71 0,000 0,1973529 0,20519925 ! appendage development GO:0048736 136 71 0,000 0,1973529 0,20511061 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 0,000 0,1973529 0,20502205 ! regulation of immune effector process GO:0002697 137 71 0,000 0,1973529 0,20493356 ! carbohydrate transport GO:0008643 110 72 0,000 0,19983729 0,20742387 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,19983729 0,20733442 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,19983729 0,20724505 ! regulation of blood pressure GO:0008217 125 73 0,000 0,20231408 0,20972326 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,20231408 0,20963294 ! fertilization GO:0009566 90 73 0,000 0,20231408 0,2095427 ! regulation of transcription factor activity GO:0051090 126 74 0,000 0,20478329 0,21200886 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 126 74 0,000 0,20478329 0,21191767 ! neurotransmitter transport GO:0006836 123 74 0,000 0,20478329 0,21182656 ! exocytosis GO:0006887 133 74 0,000 0,20478329 0,21173553 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,20478329 0,21164458 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,20478329 0,21155371 ! eye development GO:0001654 143 74 0,000 0,20478329 0,21146291 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,20724493 0,21391304 ! lymphocyte differentiation GO:0030098 167 75 0,000 0,20724493 0,21382131 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,20969904 0,21626056 ! development of primary sexual characteristics GO:0045137 124 76 0,000 0,20969904 0,2161679 ! defense response to bacterium GO:0042742 89 76 0,000 0,20969904 0,21607532 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,20969904 0,21598283 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,20969904 0,21589041 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,21214562 0,21831581 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,21214562 0,21822248 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,21214562 0,21812922 ! blood coagulation GO:0007596 146 78 0,000 0,21458472 0,22054286 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,21458472 0,22044869 ! negative regulation of organelle organization GO:0010639 161 78 0,000 0,21458472 0,2203546 ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,21458472 0,2202606 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,21701635 0,22266155 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 0,000 0,21701635 0,22256664 ! regulation of adenylate cyclase activity GO:0045761 156 80 0,000 0,21944053 0,22495693 ! response to metal ion GO:0010038 140 80 0,000 0,21944053 0,22486112 ! muscle cell differentiation GO:0042692 159 80 0,000 0,21944053 0,22476539 ! protein import into nucleus GO:0006606 158 80 0,000 0,21944053 0,22466975 ! inorganic anion transport GO:0015698 138 80 0,000 0,21944053 0,22457418 ! T cell activation GO:0042110 168 81 0,000 0,22185728 0,22695094 ! digestion GO:0007586 112 81 0,000 0,22185728 0,22685449 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,22185728 0,22675812 ! nuclear import GO:0051170 161 81 0,000 0,22185728 0,22666183 ! regulation of neuron differentiation GO:0045664 167 81 0,000 0,22185728 0,22656563 ! regulation of cAMP biosynthetic process GO:0030817 161 82 0,000 0,22426663 0,22892894 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,22426663 0,22883186 ! response to nutrient GO:0007584 125 82 0,000 0,22426663 0,22873485 ! regulation of cyclase activity GO:0031279 159 82 0,000 0,22426663 0,22863793 ! regulation of lyase activity GO:0051339 160 83 0,000 0,2266686 0,23098884 ! regulation of cAMP metabolic process GO:0030814 168 84 0,000 0,22906322 0,23333027 ! hemostasis GO:0007599 158 84 0,000 0,22906322 0,23323153 ! regulation of ligase activity GO:0051340 142 84 0,000 0,22906322 0,23313287 ! response to unfolded protein GO:0006986 131 85 0,000 0,23145049 0,23546295 ! nucleosome assembly GO:0006334 122 85 0,000 0,23145049 0,23536344 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,23145049 0,235264 ! response to inorganic substance GO:0010035 153 86 0,000 0,23383046 0,23758281 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,23383046 0,23748252 ! chromatin assembly GO:0031497 124 86 0,000 0,23383046 0,23738231 ! tube morphogenesis GO:0035239 176 86 0,000 0,23383046 0,23728219 ! alcohol catabolic process GO:0046164 130 86 0,000 0,23383046 0,23718216 ! amine transport GO:0015837 155 86 0,000 0,23383046 0,23708221 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 0,000 0,23620313 0,239387 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,23620313 0,2392862 ! protein localization in nucleus GO:0034504 176 87 0,000 0,23620313 0,2391855 ! cellular respiration GO:0045333 135 88 0,000 0,23856854 0,24147913 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,23856854 0,24137759 ! cellular defense response GO:0006968 114 89 0,000 0,2409267 0,24366105 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 0,000 0,24327763 0,24593528 ! regulation of cell cycle process GO:0010564 149 90 0,000 0,24327763 0,24583199 ! sex differentiation GO:0007548 145 90 0,000 0,24327763 0,24572879 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,24327763 0,24562567 ! sterol metabolic process GO:0016125 152 91 0,000 0,24562136 0,247888 ! response to protein stimulus GO:0051789 149 91 0,000 0,24562136 0,24778406 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,24562136 0,24768021 ! nucleosome organization GO:0034728 138 92 0,000 0,24795791 0,2499316 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,24795791 0,24982694 ! vitamin metabolic process GO:0006766 139 92 0,000 0,24795791 0,24972236 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,2502873 0,25196286 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 0,000 0,2502873 0,25185748 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,2502873 0,25175219 ! female pregnancy GO:0007565 164 94 0,000 0,25260955 0,25398185 ! transcription initiation GO:0006352 153 94 0,000 0,25260955 0,25387576 ! forebrain development GO:0030900 188 95 0,000 0,25492468 0,25609553 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,25492468 0,25598864 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,25723272 0,25819855 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,25723272 0,25809088 ! positive regulation of immune response GO:0050778 156 96 0,000 0,25723272 0,2579833 ! detection of stimulus GO:0051606 151 96 0,000 0,25723272 0,25787581 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,25953369 0,26007416 ! protein ubiquitination GO:0016567 217 97 0,000 0,25953369 0,25996589 ! response to virus GO:0009615 160 98 0,000 0,26182761 0,26215448 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,26182761 0,26204544 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,26411449 0,26422431 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,26411449 0,26411449