pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6744-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! sarcomere organization GO:0045214 23 19 8,000 1,589E-15 3,654E-12 ! myofibril assembly GO:0030239 36 27 8,000 7,712E-14 8,869E-11 GO:0055002|striated muscle cell development, ! response to calcium ion GO:0051592 58 40 9,000 7,992E-14 6,127E-11 ! muscle cell development GO:0055001 38 29 8,000 1,63E-13 9,372E-11 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 8,000 3,245E-13 1,493E-10 ! actomyosin structure organization GO:0031032 43 33 8,000 6,139E-13 2,353E-10 ! response to metal ion GO:0010038 103 70 10,000 1,055E-12 3,465E-10 ! response to inorganic substance GO:0010035 115 75 10,000 2,322E-12 6,676E-10 ! striated muscle cell differentiation GO:0051146 54 38 8,000 2,524E-12 6,451E-10 ! muscle cell differentiation GO:0042692 104 71 8,000 9,61E-10 2,21E-07 ! negative regulation of phosphorylation GO:0042326 41 23 5,000 6,897E-09 1,442E-06 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 1,197E-08 2,294E-06 GO:0045936|negative regulation of phosphate metabolic process, ! induction of positive chemotaxis GO:0050930 14 8 3,000 1,262E-07 2,233E-05 ! sex determination GO:0007530 29 19 4,000 1,273E-07 2,092E-05 ! positive regulation of locomotion GO:0040017 35 20 4,000 1,689E-07 2,589E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 4,000 2,205E-07 3,169E-05 ! regulation of behavior GO:0050795 38 22 4,000 2,838E-07 3,84E-05 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 3,739E-07 4,778E-05 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 5,859E-07 7,092E-05 GO:0050927|positive regulation of positive chemotaxis, ! C21-steroid hormone biosynthetic process GO:0006700 15 14 3,000 1,75E-06 2,013E-04 ! negative regulation of ligase activity GO:0051352 91 61 5,000 3,09E-06 3,385E-04 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! proximal/distal pattern formation GO:0009954 25 17 3,000 4,097E-06 4,284E-04 ! pigmentation GO:0043473 74 38 4,000 4,97E-06 4,97E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 5,241E-06 5,023E-04 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 6,447E-06 5,931E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 6,447E-06 5,703E-04 ! C21-steroid hormone metabolic process GO:0008207 23 19 3,000 6,605E-06 5,626E-04 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 6,605E-06 5,425E-04 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 5,000 7,553E-06 5,99E-04 ! positive regulation of inflammatory response GO:0050729 30 20 3,000 8,214E-06 6,297E-04 ! digestion GO:0007586 97 74 5,000 9,613E-06 7,132E-04 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 9,772E-06 7,024E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 9,772E-06 6,811E-04 ! regulation of ligase activity GO:0051340 114 75 5,000 1,039E-05 7,03E-04 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 4,000 1,042E-05 6,846E-04 ! regulation of mast cell proliferation GO:0070666 64 44 4,000 1,042E-05 6,656E-04 ! regulation of leukocyte proliferation GO:0070663 71 47 4,000 1,448E-05 9,003E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 1,556E-05 9,418E-04 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 1,556E-05 9,176E-04 ! neurotransmitter secretion GO:0007269 32 24 3,000 1,765E-05 1,015E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 2,172E-05 1,218E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 2,172E-05 1,189E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 5,000 2,287E-05 1,223E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,323E-05 1,214E-03 ! interphase GO:0051325 159 88 5,000 2,608E-05 1,333E-03 ! reproductive developmental process GO:0003006 127 89 5,000 2,782E-05 1,391E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 3,302E-05 1,616E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 2,000 3,302E-05 1,582E-03 ! regulation of B cell activation GO:0050864 42 28 3,000 3,332E-05 1,564E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 3,439E-05 1,582E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 3,75E-05 1,691E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 4,082E-05 1,806E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 4,518E-05 1,961E-03 ! regulation of leukocyte migration GO:0002685 24 11 2,000 4,518E-05 1,924E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 4,518E-05 1,889E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 4,518E-05 1,856E-03 GO:0042130|negative regulation of T cell proliferation, ! embryonic limb morphogenesis GO:0030326 86 60 4,000 4,815E-05 1,943E-03 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 4,000 4,815E-05 1,909E-03 ! leukocyte chemotaxis GO:0030595 43 31 3,000 5,042E-05 1,966E-03 GO:0060326|cell chemotaxis, ! negative regulation of transferase activity GO:0051348 105 61 4,000 5,217E-05 2E-03 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 4,000 5,217E-05 1,967E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 5,645E-05 2,094E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 4,000 5,645E-05 2,061E-03 ! gland morphogenesis GO:0022612 23 12 2,000 5,995E-05 2,155E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 6,099E-05 2,158E-03 ! hormone biosynthetic process GO:0042446 45 33 3,000 6,491E-05 2,262E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 6,581E-05 2,259E-03 ! appendage morphogenesis GO:0035107 93 64 4,000 6,581E-05 2,226E-03 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 94 65 4,000 7,092E-05 2,364E-03 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 4,000 7,092E-05 2,33E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 4,000 7,092E-05 2,297E-03 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 3,000 7,318E-05 2,338E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 7,756E-05 2,444E-03 ! positive regulation of ligase activity GO:0051351 99 69 4,000 9,448E-05 2,937E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 9,824E-05 3,013E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 9,824E-05 2,973E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 1,012E-04 3,023E-03 ! regulation of T cell proliferation GO:0042129 58 38 3,000 1,141E-04 3,365E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 1,158E-04 3,371E-03 GO:0045937|positive regulation of phosphate metabolic process, ! embryonic forelimb morphogenesis GO:0035115 17 15 2,000 1,222E-04 3,513E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,222E-04 3,47E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,222E-04 3,428E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,222E-04 3,386E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 1,222E-04 3,346E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,222E-04 3,307E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 2,000 1,222E-04 3,268E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,265E-04 3,345E-03 ! negative regulation of growth GO:0045926 123 75 4,000 1,406E-04 3,674E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,497E-04 3,868E-03 ! regulation of T cell differentiation GO:0045580 59 41 3,000 1,542E-04 3,941E-03 ! forelimb morphogenesis GO:0035136 19 17 2,000 1,809E-04 4,572E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,809E-04 4,522E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,809E-04 4,473E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,809E-04 4,426E-03 ! leukocyte migration GO:0050900 60 43 3,000 1,86E-04 4,503E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 4,000 1,907E-04 4,57E-03 GO:0010498|proteasomal protein catabolic process, ! regulation of inflammatory response GO:0050727 60 44 3,000 2,036E-04 4,827E-03 ! regulation of glucose import GO:0046324 21 18 2,000 2,16E-04 5,069E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 2,16E-04 5,018E-03 ! positive regulation of defense response GO:0031349 59 45 3,000 2,223E-04 5,112E-03 ! response to UV GO:0009411 75 46 3,000 2,422E-04 5,516E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 2,553E-04 5,756E-03 ! response to alkaloid GO:0043279 32 19 2,000 2,553E-04 5,7E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 2,553E-04 5,645E-03 ! cell cycle arrest GO:0007050 150 86 4,000 2,677E-04 5,864E-03 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 2,859E-04 6,203E-03 ! positive regulation of B cell activation GO:0050871 31 20 2,000 2,989E-04 6,424E-03 ! collagen catabolic process GO:0030574 25 20 2,000 2,989E-04 6,365E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 3,47E-04 7,322E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 3,47E-04 7,255E-03 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 3,47E-04 7,19E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 3,851E-04 7,908E-03 ! vasculogenesis GO:0001570 33 22 2,000 3,998E-04 8,138E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 3,998E-04 8,067E-03 GO:0010810|regulation of cell-substrate adhesion, ! leukocyte homeostasis GO:0001776 33 22 2,000 3,998E-04 7,997E-03 ! regulation of bone remodeling GO:0046850 90 53 3,000 4,194E-04 8,315E-03 ! regulation of neurotransmitter levels GO:0001505 73 53 3,000 4,194E-04 8,244E-03 ! regulation of binding GO:0051098 151 95 4,000 4,248E-04 8,281E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,308E-04 8,327E-03 ! regulation of collagen biosynthetic process GO:0032965 6 5 1,000 4,308E-04 8,258E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 4,308E-04 8,19E-03 ! response to protozoan GO:0001562 9 5 1,000 4,308E-04 8,123E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 4,308E-04 8,057E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 4,308E-04 7,992E-03 ! neutrophil mediated immunity GO:0002446 6 5 1,000 4,308E-04 7,928E-03 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 1,000 4,308E-04 7,865E-03 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 1,000 4,308E-04 7,803E-03 GO:0030033|microvillus assembly, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 4,308E-04 7,742E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 4,308E-04 7,682E-03 ! neural tube patterning GO:0021532 6 5 1,000 4,308E-04 7,623E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 4,308E-04 7,565E-03 ! triglyceride catabolic process GO:0019433 6 5 1,000 4,308E-04 7,507E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 4,308E-04 7,451E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 4,308E-04 7,395E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 4,308E-04 7,34E-03 ! regulation of response to external stimulus GO:0032101 139 96 4,000 4,458E-04 7,54E-03 ! regulation of tissue remodeling GO:0034103 91 54 3,000 4,506E-04 7,565E-03 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 4,576E-04 7,626E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 5,135E-04 8,497E-03 ! male gonad development GO:0008584 33 25 2,000 5,886E-04 9,669E-03 ! regulation of chromosome organization GO:0033044 35 25 2,000 5,886E-04 9,601E-03 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 5,886E-04 9,533E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 6,435E-04 0,01034946 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 6,435E-04 0,01027759 ! mRNA stabilization GO:0048255 15 6 1,000 6,435E-04 0,01020671 GO:0043489|RNA stabilization, ! pigment granule organization GO:0048753 11 6 1,000 6,435E-04 0,0101368 ! ER overload response GO:0006983 7 6 1,000 6,435E-04 0,01006784 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 6,435E-04 1E-02 ! glycerol ether catabolic process GO:0044269 8 6 1,000 6,435E-04 9,933E-03 GO:0046464|acylglycerol catabolic process, ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 6,435E-04 9,866E-03 ! regulation of collagen metabolic process GO:0010712 7 6 1,000 6,435E-04 9,801E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 6,435E-04 9,737E-03 ! neutrophil homeostasis GO:0001780 6 6 1,000 6,435E-04 9,673E-03 ! salivary gland morphogenesis GO:0007435 11 6 1,000 6,435E-04 9,61E-03 ! midbrain development GO:0030901 6 6 1,000 6,435E-04 9,548E-03 ! organ or tissue specific immune response GO:0002251 7 6 1,000 6,435E-04 9,487E-03 ! negative regulation of B cell activation GO:0050869 9 6 1,000 6,435E-04 9,427E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 6,435E-04 9,367E-03 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 2,000 6,621E-04 9,578E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 6,621E-04 9,518E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 6,621E-04 9,459E-03 ! multicellular organismal catabolic process GO:0044243 32 26 2,000 6,621E-04 9,4E-03 ! regulation of homeostatic process GO:0032844 105 60 3,000 6,739E-04 9,509E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 7,413E-04 0,01039622 ! neurotransmitter transport GO:0006836 81 62 3,000 7,632E-04 0,01063792 ! cellular hormone metabolic process GO:0034754 87 62 3,000 7,632E-04 0,01057383 ! regulation of transcription factor activity GO:0051090 97 63 3,000 8,108E-04 0,01116614 GO:0090046|regulation of transcription regulator activity, ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 8,263E-04 0,0113118 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 8,604E-04 0,01170989 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 8,969E-04 0,01213513 ! neutral lipid catabolic process GO:0046461 9 7 1,000 8,969E-04 0,01206416 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 8,969E-04 0,01199402 ! microtubule bundle formation GO:0001578 8 7 1,000 8,969E-04 0,01192469 ! T-helper 1 type immune response GO:0042088 11 7 1,000 8,969E-04 0,01185616 ! glycerolipid catabolic process GO:0046503 9 7 1,000 8,969E-04 0,01178841 ! regulation of pigmentation during development GO:0048070 15 7 1,000 8,969E-04 0,01172143 ! organ growth GO:0035265 11 7 1,000 8,969E-04 0,01165521 ! behavioral fear response GO:0001662 13 7 1,000 8,969E-04 0,01158973 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 8,969E-04 0,01152498 ! B cell lineage commitment GO:0002326 17 7 1,000 8,969E-04 0,01146096 ! T cell lineage commitment GO:0002360 12 7 1,000 8,969E-04 0,01139764 ! peptidyl-threonine modification GO:0018210 18 7 1,000 8,969E-04 0,01133501 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 8,969E-04 0,01127307 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 1,000 8,969E-04 0,0112118 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 8,969E-04 0,0111512 ! defense response to Gram-negative bacterium GO:0050829 9 7 1,000 8,969E-04 0,01109125 ! collagen metabolic process GO:0032963 40 30 2,000 1,014E-03 0,01247356 ! hindbrain development GO:0030902 45 30 2,000 1,014E-03 0,01240721 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,014E-03 0,01234156 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 1,117E-03 0,01352656 ! metanephros development GO:0001656 58 31 2,000 1,117E-03 0,01345574 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,191E-03 0,01426406 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,191E-03 0,01419016 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,191E-03 0,01411701 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,191E-03 0,01404462 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,191E-03 0,01397296 ! melanin metabolic process GO:0006582 12 8 1,000 1,191E-03 0,01390203 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,191E-03 0,01383182 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,191E-03 0,01376231 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 1,000 1,191E-03 0,0136935 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,191E-03 0,01362537 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,191E-03 0,01355792 ! myeloid cell homeostasis GO:0002262 8 8 1,000 1,191E-03 0,01349113 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,191E-03 0,013425 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,191E-03 0,01335951 ! regulation of muscle development GO:0048634 48 32 2,000 1,227E-03 0,01370036 ! regulation of protein stability GO:0031647 48 32 2,000 1,227E-03 0,01363417 ! steroid biosynthetic process GO:0006694 94 71 3,000 1,27E-03 0,01404098 ! response to hypoxia GO:0001666 132 72 3,000 1,338E-03 0,01472084 ! nucleus organization GO:0006997 49 33 2,000 1,343E-03 0,01471225 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 2,000 1,343E-03 0,01464252 ! negative regulation of transport GO:0051051 116 73 3,000 1,408E-03 0,01527606 ! mitochondrion organization GO:0007005 104 73 3,000 1,408E-03 0,01520435 ! response to steroid hormone stimulus GO:0048545 114 73 3,000 1,408E-03 0,0151333 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 1,466E-03 0,01568499 ! response to oxygen levels GO:0070482 137 74 3,000 1,481E-03 0,01576967 ! lung alveolus development GO:0048286 17 9 1,000 1,524E-03 0,01615633 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,524E-03 0,01608222 ! T cell selection GO:0045058 18 9 1,000 1,524E-03 0,01600878 ! myeloid leukocyte mediated immunity GO:0002444 11 9 1,000 1,524E-03 0,01593601 ! motor axon guidance GO:0008045 14 9 1,000 1,524E-03 0,01586391 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,524E-03 0,01579245 ! oocyte differentiation GO:0009994 12 9 1,000 1,524E-03 0,01572163 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,524E-03 0,01565144 ! spleen development GO:0048536 15 9 1,000 1,524E-03 0,01558188 ! detection of calcium ion GO:0005513 13 9 1,000 1,524E-03 0,01551293 ! defense response to Gram-positive bacterium GO:0050830 10 9 1,000 1,524E-03 0,01544459 ! response to nicotine GO:0035094 16 9 1,000 1,524E-03 0,01537686 ! localization within membrane GO:0051668 15 9 1,000 1,524E-03 0,01530971 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 1,596E-03 0,01595956 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of DNA binding GO:0051101 119 77 3,000 1,715E-03 0,01708065 ! gland development GO:0048732 148 77 3,000 1,715E-03 0,01700702 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 1,733E-03 0,01710369 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 2,000 1,733E-03 0,0170306 ! neural tube development GO:0021915 50 36 2,000 1,733E-03 0,01695813 ! positive regulation of protein modification process GO:0031401 107 78 3,000 1,799E-03 0,01753331 ! negative regulation of muscle development GO:0048635 12 10 1,000 1,897E-03 0,01841104 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,897E-03 0,01833369 ! blood vessel remodeling GO:0001974 21 10 1,000 1,897E-03 0,01825698 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 1,897E-03 0,0181809 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 1,897E-03 0,01810547 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,897E-03 0,01803065 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,897E-03 0,01795645 ! B cell proliferation GO:0042100 14 10 1,000 1,897E-03 0,01788286 ! fear response GO:0042596 16 10 1,000 1,897E-03 0,01780987 ! negative regulation of ossification GO:0030279 19 10 1,000 1,897E-03 0,01773747 ! regulation of bone resorption GO:0045124 24 10 1,000 1,897E-03 0,01766566 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,897E-03 0,01759442 ! positive regulation of interleukin-6 production GO:0032755 13 10 1,000 1,897E-03 0,01752376 ! DNA methylation GO:0006306 15 10 1,000 1,897E-03 0,01745367 GO:0006305|DNA alkylation, ! salivary gland development GO:0007431 22 10 1,000 1,897E-03 0,01738413 ! positive regulation of acute inflammatory response GO:0002675 14 10 1,000 1,897E-03 0,01731515 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 2,186E-03 0,01987261 ! male sex differentiation GO:0046661 53 39 2,000 2,186E-03 0,01979437 ! regulation of cell adhesion GO:0030155 159 83 3,000 2,26E-03 0,02038137 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,309E-03 0,02074208 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,309E-03 0,02066137 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 2,309E-03 0,02058129 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 2,309E-03 0,02050182 ! plasma membrane organization GO:0007009 18 11 1,000 2,309E-03 0,02042297 ! focal adhesion formation GO:0048041 24 11 1,000 2,309E-03 0,02034472 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 2,309E-03 0,02026707 ! T cell homeostasis GO:0043029 20 11 1,000 2,309E-03 0,02019001 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 1,000 2,309E-03 0,02011353 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,309E-03 0,02003763 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! actin filament polymerization GO:0030041 17 11 1,000 2,309E-03 0,0199623 ! T cell differentiation GO:0030217 65 40 2,000 2,352E-03 0,02025971 ! positive regulation of protein transport GO:0051222 55 40 2,000 2,352E-03 0,02018412 ! regulation of defense response GO:0031347 117 84 3,000 2,361E-03 0,02018413 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 2,465E-03 0,0209958 ! anterior/posterior pattern formation GO:0009952 124 85 3,000 2,465E-03 0,02091832 ! regulation of protein localization GO:0032880 132 85 3,000 2,465E-03 0,02084142 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 2,465E-03 0,02076507 ! positive regulation of DNA binding GO:0043388 57 41 2,000 2,525E-03 0,02119853 ! cellular component disassembly GO:0022411 64 42 2,000 2,707E-03 0,02263709 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,758E-03 0,02298691 ! Golgi organization GO:0007030 18 12 1,000 2,758E-03 0,02290393 ! histone acetylation GO:0016573 23 12 1,000 2,758E-03 0,02282154 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,758E-03 0,02273974 ! response to gamma radiation GO:0010332 20 12 1,000 2,758E-03 0,02265853 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,758E-03 0,02257789 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,758E-03 0,02249783 ! positive regulation of binding GO:0051099 59 43 2,000 2,896E-03 0,02353359 ! activation of caspase activity GO:0006919 65 43 2,000 2,896E-03 0,02345072 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 2,896E-03 0,02336844 ! regulation of T cell activation GO:0050863 128 89 3,000 2,913E-03 0,02342254 ! hormone metabolic process GO:0042445 121 90 3,000 3,033E-03 0,02430324 ! negative regulation of cell migration GO:0030336 92 44 2,000 3,093E-03 0,02469815 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 3,093E-03 0,02461269 ! response to virus GO:0009615 122 91 3,000 3,156E-03 0,02503068 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 3,246E-03 0,02565456 ! regulation of chemokine production GO:0032642 17 13 1,000 3,246E-03 0,02556671 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 3,246E-03 0,02547945 ! endocrine pancreas development GO:0031018 19 13 1,000 3,246E-03 0,02539278 ! exocrine system development GO:0035272 27 13 1,000 3,246E-03 0,02530671 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 3,246E-03 0,02522121 ! regulation of exocytosis GO:0017157 17 13 1,000 3,246E-03 0,02513629 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 3,246E-03 0,02505194 ! cellular pigmentation GO:0033059 24 13 1,000 3,246E-03 0,02496816 ! regulation of acute inflammatory response GO:0002673 19 13 1,000 3,246E-03 0,02488493 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 1,000 3,246E-03 0,02480225 ! regulation of RNA stability GO:0043487 28 13 1,000 3,246E-03 0,02472013 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,246E-03 0,02463854 ! positive regulation of cell cycle GO:0045787 77 45 2,000 3,298E-03 0,02494943 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 3,298E-03 0,02486762 ! regulation of ossification GO:0030278 71 46 2,000 3,511E-03 0,02638863 ! response to estrogen stimulus GO:0043627 74 47 2,000 3,732E-03 0,02796149 ! negative regulation of immune system process GO:0002683 73 47 2,000 3,732E-03 0,02787071 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 3,77E-03 0,02806494 ! epidermis morphogenesis GO:0048730 29 14 1,000 3,77E-03 0,02797441 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 3,77E-03 0,02788446 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 3,77E-03 0,02779509 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,77E-03 0,02770628 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 1,000 3,77E-03 0,02761805 ! regulation of T-helper 2 type immune response GO:0002828 21 14 1,000 3,77E-03 0,02753037 ! peptide hormone secretion GO:0030072 23 14 1,000 3,77E-03 0,02744325 ! response to light stimulus GO:0009416 153 96 3,000 3,825E-03 0,02775103 ! positive regulation of caspase activity GO:0043280 72 48 2,000 3,962E-03 0,02865605 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 3,962E-03 0,02856622 ! regulation of angiogenesis GO:0045765 94 49 2,000 4,2E-03 0,03018897 ! germ cell development GO:0007281 68 49 2,000 4,2E-03 0,03009492 ! cartilage development GO:0051216 70 49 2,000 4,2E-03 0,03000146 ! metencephalon development GO:0022037 19 15 1,000 4,332E-03 0,03084517 ! negative regulation of hormone secretion GO:0046888 20 15 1,000 4,332E-03 0,03074997 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 4,332E-03 0,03065535 ! regulation of survival gene product expression GO:0045884 20 15 1,000 4,332E-03 0,03056132 ! peptide secretion GO:0002790 27 15 1,000 4,332E-03 0,03046786 ! regulation of T-helper cell differentiation GO:0045622 23 15 1,000 4,332E-03 0,03037497 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 4,332E-03 0,03028265 ! ear development GO:0043583 72 50 2,000 4,447E-03 0,03099372 ! negative regulation of cell motion GO:0051271 104 51 2,000 4,702E-03 0,03267431 ! hormone secretion GO:0046879 25 16 1,000 4,929E-03 0,03414788 ! protein amino acid acetylation GO:0006473 28 16 1,000 4,929E-03 0,03404533 ! regulation of protein binding GO:0043393 27 16 1,000 4,929E-03 0,0339434 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 1,000 4,929E-03 0,03384207 ! oogenesis GO:0048477 23 16 1,000 4,929E-03 0,03374135 ! negative regulation of translation GO:0017148 22 16 1,000 4,929E-03 0,03364123 ! aging GO:0007568 79 52 2,000 4,966E-03 0,0337943 ! kidney development GO:0001822 90 53 2,000 5,239E-03 0,03554557 ! cytokine-mediated signaling pathway GO:0019221 76 54 2,000 5,521E-03 0,03734647 ! DNA catabolic process GO:0006308 67 54 2,000 5,521E-03 0,03723695 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 1,000 5,562E-03 0,03740713 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 1,000 5,562E-03 0,03729808 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 5,562E-03 0,03718965 ! regulation of viral genome replication GO:0045069 24 17 1,000 5,562E-03 0,03708186 ! cell-substrate junction assembly GO:0007044 39 17 1,000 5,562E-03 0,03697468 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 5,562E-03 0,03686813 ! actin polymerization or depolymerization GO:0008154 31 17 1,000 5,562E-03 0,03676218 ! neuromuscular junction development GO:0007528 23 17 1,000 5,562E-03 0,03665685 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 5,562E-03 0,03655211 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 6,111E-03 0,04004371 ! positive regulation of translation GO:0045727 28 18 1,000 6,231E-03 0,04071107 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 6,231E-03 0,04059574 ! pancreas development GO:0031016 26 18 1,000 6,231E-03 0,04048106 ! pigmentation during development GO:0048066 31 18 1,000 6,231E-03 0,04036703 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 6,231E-03 0,04025364 ! somitogenesis GO:0001756 24 18 1,000 6,231E-03 0,04014088 ! detection of chemical stimulus GO:0009593 26 18 1,000 6,231E-03 0,04002876 ! hormone transport GO:0009914 27 18 1,000 6,231E-03 0,03991726 ! gut development GO:0048565 26 18 1,000 6,231E-03 0,03980638 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 6,231E-03 0,03969611 ! gonad development GO:0008406 79 57 2,000 6,42E-03 0,0407883 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 6,934E-03 0,04393152 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 6,934E-03 0,04381083 ! regeneration GO:0031099 32 19 1,000 6,934E-03 0,0436908 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 6,934E-03 0,04357143 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 6,934E-03 0,0434527 ! renal system process GO:0003014 35 19 1,000 6,934E-03 0,04333463 ! regulation of interleukin-6 production GO:0032675 22 19 1,000 6,934E-03 0,04321719 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 6,934E-03 0,04310038 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 6,934E-03 0,04298421 ! lung development GO:0030324 94 59 2,000 7,065E-03 0,04367931 ! actin filament organization GO:0007015 95 59 2,000 7,065E-03 0,0435622 ! regulation of heart contraction GO:0008016 91 60 2,000 7,401E-03 0,04551422 ! hindlimb morphogenesis GO:0035137 32 20 1,000 7,671E-03 0,04704713 ! response to ethanol GO:0045471 37 20 1,000 7,671E-03 0,046922 ! multicellular organismal response to stress GO:0033555 32 20 1,000 7,671E-03 0,04679754 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 7,671E-03 0,04667374 ! DNA modification GO:0006304 28 20 1,000 7,671E-03 0,04655059 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 7,671E-03 0,04642809 ! urogenital system development GO:0001655 101 61 2,000 7,747E-03 0,04676487 ! homeostasis of number of cells GO:0048872 84 61 2,000 7,747E-03 0,04664245 ! respiratory tube development GO:0030323 99 62 2,000 8,102E-03 0,0486531 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 8,442E-03 0,05056195 ! protein amino acid acylation GO:0043543 37 21 1,000 8,442E-03 0,05043062 ! dendrite development GO:0016358 35 21 1,000 8,442E-03 0,05029997 ! ovarian follicle development GO:0001541 30 21 1,000 8,442E-03 0,05017 ! cell aging GO:0007569 32 21 1,000 8,442E-03 0,05004069 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 8,442E-03 0,04991205 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 8,442E-03 0,04978408 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 8,442E-03 0,04965675 ! platelet activation GO:0030168 28 21 1,000 8,442E-03 0,04953007 ! positive regulation of protein secretion GO:0050714 26 21 1,000 8,442E-03 0,04940404 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 8,442E-03 0,04927865 ! response to cytokine stimulus GO:0034097 47 21 1,000 8,442E-03 0,0491539 ! respiratory system development GO:0060541 100 64 2,000 8,84E-03 0,05134583 ! reproductive structure development GO:0048608 90 65 2,000 9,224E-03 0,053439 ! regulation of caspase activity GO:0043281 97 65 2,000 9,224E-03 0,05330473 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 9,246E-03 0,05329676 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 9,246E-03 0,05316352 ! molting cycle process GO:0022404 40 22 1,000 9,246E-03 0,05303094 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! ureteric bud development GO:0001657 32 22 1,000 9,246E-03 0,05289902 ! neural tube closure GO:0001843 33 22 1,000 9,246E-03 0,05276776 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01002016 0,05704547 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,0100828 0,05726037 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,0100828 0,05711933 ! myelination GO:0042552 35 23 1,000 0,0100828 0,05697899 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,0100828 0,05683934 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,0100828 0,05670037 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,0100828 0,05656207 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,0100828 0,05642445 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,0100828 0,0562875 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,0100828 0,05615121 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 0,0100828 0,05601558 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01043275 0,05782009 ! response to drug GO:0042493 108 69 2,000 0,01085509 0,06001614 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01095211 0,06040732 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01095211 0,06026281 ! response to toxin GO:0009636 38 24 1,000 0,01095211 0,06011898 ! primary neural tube formation GO:0014020 35 24 1,000 0,01095211 0,05997584 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,01095211 0,05983338 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01095211 0,0596916 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01095211 0,05955048 ! humoral immune response GO:0006959 86 70 2,000 0,01128722 0,06122782 ! eye development GO:0001654 111 70 2,000 0,01128722 0,06108375 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,01172916 0,06332645 ! peptide transport GO:0015833 43 25 1,000 0,01185329 0,06384675 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01185329 0,06369758 ! response to estradiol stimulus GO:0032355 34 25 1,000 0,01185329 0,0635491 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01185329 0,06340131 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01185329 0,06325421 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01185329 0,06310779 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01185329 0,06296204 GO:0032943|mononuclear cell proliferation, ! regulation of peptidase activity GO:0052547 106 72 2,000 0,01218096 0,0645535 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01218096 0,0644051 ! tube morphogenesis GO:0035239 118 73 2,000 0,01264266 0,06669293 ! post-embryonic development GO:0009791 42 26 1,000 0,01278589 0,06729414 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01278589 0,0671405 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,01311428 0,06870808 ! blood coagulation GO:0007596 116 75 2,000 0,01359586 0,07106924 GO:0050817|coagulation, ! acute-phase response GO:0006953 42 27 1,000 0,01374945 0,07170917 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01374945 0,07154693 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01374945 0,07138542 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01374945 0,07122465 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01374945 0,07106459 ! regulation of protein transport GO:0051223 114 76 2,000 0,01408741 0,07264809 GO:0070201|regulation of establishment of protein localization, ! sex differentiation GO:0007548 105 77 2,000 0,01458898 0,07506632 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01474355 0,07569231 ! cell junction assembly GO:0034329 56 28 1,000 0,01474355 0,07552373 ! triglyceride metabolic process GO:0006641 34 28 1,000 0,01474355 0,0753559 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01474355 0,07518881 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,01474355 0,07502247 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01474355 0,07485686 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01474355 0,07469197 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01474355 0,07452781 ! T cell activation GO:0042110 134 79 2,000 0,01562222 0,0787963 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01576772 0,07935616 ! ovulation cycle process GO:0022602 41 29 1,000 0,01576772 0,07918289 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,01576772 0,07901038 ! tissue homeostasis GO:0001894 42 29 1,000 0,01576772 0,07883862 GO:0048871|multicellular organismal homeostasis, ! hemostasis GO:0007599 125 81 2,000 0,01669576 0,08329774 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,01669576 0,08311744 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,01669576 0,08293792 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,01682155 0,08338268 ! spindle organization GO:0007051 37 30 1,000 0,01682155 0,08320336 ! ovulation cycle GO:0042698 43 30 1,000 0,01682155 0,08302481 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01682155 0,08284703 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01682155 0,08267001 ! response to heat GO:0009408 41 30 1,000 0,01682155 0,08249374 ! ossification GO:0001503 134 82 2,000 0,01724769 0,08440359 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 2,000 0,01724769 0,08422439 ! negative regulation of secretion GO:0051048 49 31 1,000 0,01790459 0,08724696 ! mammary gland development GO:0030879 57 31 1,000 0,01790459 0,0870625 ! glial cell differentiation GO:0010001 55 31 1,000 0,01790459 0,08687883 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 1,000 0,01790459 0,08669593 ! segmentation GO:0035282 41 31 1,000 0,01790459 0,08651379 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01790459 0,08633242 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01838193 0,08844861 ! regulation of membrane potential GO:0042391 128 85 2,000 0,01896427 0,09106015 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01901643 0,09112038 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,01901643 0,09093094 ! meiosis I GO:0007127 52 32 1,000 0,01901643 0,09074229 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,01901643 0,09055442 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 1,000 0,01901643 0,09036732 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01901643 0,090181 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,01901643 0,08999544 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02015663 0,09519558 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02015663 0,09500051 ! ear morphogenesis GO:0042471 42 33 1,000 0,02015663 0,09480624 ! cell junction organization GO:0034330 63 33 1,000 0,02015663 0,09461275 ! female gonad development GO:0008585 49 33 1,000 0,02015663 0,09442006 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02015663 0,09422815 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02015663 0,09403702 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,02015663 0,09384666 ! cytokinesis GO:0000910 52 33 1,000 0,02015663 0,09365707 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02015942 0,0934812 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,02015942 0,0932931 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02132478 0,09848795 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,02132478 0,09829058 ! neuron migration GO:0001764 46 34 1,000 0,02132478 0,098094 ! female gamete generation GO:0007292 43 34 1,000 0,02132478 0,0978982 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,02132478 0,09770318 ! leukocyte differentiation GO:0002521 143 90 2,000 0,02202847 0,10072659 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02252047 0,10277198 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02252047 0,10256847 ! glycogen metabolic process GO:0005977 48 35 1,000 0,02252047 0,10236576 ! pigment metabolic process GO:0042440 61 35 1,000 0,02252047 0,10216386 ! protein homooligomerization GO:0051260 52 35 1,000 0,02252047 0,10196275 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,02374328 0,1072879 ! negative regulation of binding GO:0051100 58 36 1,000 0,02374328 0,10707753 ! organic ether metabolic process GO:0018904 46 36 1,000 0,02374328 0,10686799 ! tissue remodeling GO:0048771 62 36 1,000 0,02374328 0,10665926 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02374328 0,10645135 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,02374328 0,10624425 GO:0006073|cellular glucan metabolic process, ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,02398915 0,10713601 ! response to oxidative stress GO:0006979 141 94 2,000 0,02466307 0,10993231 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,02499281 0,11118658 ! regulation of protein secretion GO:0050708 51 37 1,000 0,02499281 0,11097193 ! amino acid activation GO:0043038 52 37 1,000 0,02499281 0,11075811 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! angiogenesis GO:0001525 149 95 2,000 0,02534717 0,1121125 ! gliogenesis GO:0042063 71 38 1,000 0,02626866 0,11596528 ! mesenchymal cell development GO:0014031 64 38 1,000 0,02626866 0,11574312 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02757042 0,1212466 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,02757042 0,12101521 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,02757042 0,12078471 ! developmental growth GO:0048589 62 39 1,000 0,02757042 0,12055508 ! synapse organization GO:0050808 55 39 1,000 0,02757042 0,12032632 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02889771 0,12588019 ! ATP synthesis coupled electron transport GO:0042773 48 40 1,000 0,02889771 0,12564223 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! B cell differentiation GO:0030183 62 40 1,000 0,02889771 0,12540517 ! regulation of translation GO:0006417 151 100 2,000 0,02892007 0,12526582 ! regulation of body fluid levels GO:0050878 154 100 2,000 0,02892007 0,12503036 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03025014 0,13053531 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,03025014 0,13029086 ! biopolymer methylation GO:0043414 62 41 1,000 0,03025014 0,13004733 ! mitochondrial transport GO:0006839 60 42 1,000 0,03162732 0,13571423 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,03162732 0,1354615 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,03162732 0,13520972 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,03162732 0,13495886 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,03162732 0,13470894 ! regulation of cell shape GO:0008360 78 42 1,000 0,03162732 0,13445994 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03274331 0,13894761 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03274331 0,13869172 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03274331 0,13843677 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03274331 0,13818276 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03274331 0,13792967 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03274331 0,13767752 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03274331 0,13742628 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03274331 0,13717596 ! sleep GO:0030431 11 5 0,000 0,03274331 0,13692655 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03274331 0,13667804 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03274331 0,13643044 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03274331 0,13618373 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03274331 0,13593791 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03274331 0,13569298 ! tongue development GO:0043586 6 5 0,000 0,03274331 0,13544893 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03274331 0,13520575 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03274331 0,13496345 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03274331 0,13472201 ! cobalt ion transport GO:0006824 9 5 0,000 0,03274331 0,13448143 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03274331 0,13424172 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03274331 0,13400285 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03274331 0,13376484 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03274331 0,13352766 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03274331 0,13329133 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03274331 0,13305583 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03274331 0,13282117 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03274331 0,13258733 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03274331 0,13235431 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03274331 0,13212211 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03274331 0,13189072 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03274331 0,13166014 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03274331 0,13143037 ! malate metabolic process GO:0006108 7 5 0,000 0,03274331 0,1312014 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03274331 0,13097322 ! behavioral response to pain GO:0048266 7 5 0,000 0,03274331 0,13074584 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03274331 0,13051924 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03274331 0,13029343 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03274331 0,1300684 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03274331 0,12984414 ! mating behavior GO:0007617 6 5 0,000 0,03274331 0,12962066 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03274331 0,12939794 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03274331 0,12917599 ! rhythmic behavior GO:0007622 12 5 0,000 0,03274331 0,1289548 ! copulation GO:0007620 7 5 0,000 0,03274331 0,12873436 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03274331 0,12851468 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03274331 0,12829575 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03274331 0,12807756 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03274331 0,12786011 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03274331 0,12764339 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03274331 0,12742742 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03274331 0,12721217 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03274331 0,12699764 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03274331 0,12678384 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03274331 0,12657076 ! lymph vessel development GO:0001945 7 5 0,000 0,03274331 0,12635839 ! endochondral ossification GO:0001958 12 5 0,000 0,03274331 0,12614674 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03274331 0,12593579 ! parathyroid gland development GO:0060017 8 5 0,000 0,03274331 0,12572555 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03274331 0,125516 ! anagen GO:0042640 6 5 0,000 0,03274331 0,12530716 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03274331 0,12509901 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03274331 0,12489155 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03274331 0,12468477 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03274331 0,12447868 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03274331 0,12427327 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03274331 0,12406854 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03274331 0,12386448 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03274331 0,12366109 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03274331 0,12345836 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03274331 0,12325631 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03274331 0,12305491 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03274331 0,12285416 ! ovulation GO:0030728 6 5 0,000 0,03274331 0,12265408 ! valine metabolic process GO:0006573 8 5 0,000 0,03274331 0,12245464 ! response to pH GO:0009268 9 5 0,000 0,03274331 0,12225585 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03274331 0,1220577 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03274331 0,1218602 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03274331 0,12166333 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03274331 0,1214671 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03274331 0,1212715 ! polyol catabolic process GO:0046174 7 5 0,000 0,03274331 0,12107653 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03274331 0,12088219 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03274331 0,12068847 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03274331 0,12049536 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03274331 0,12030288 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03274331 0,12011101 ! urea metabolic process GO:0019627 6 5 0,000 0,03274331 0,11991975 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03274331 0,1197291 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03274331 0,11953905 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03274331 0,11934961 ! neutrophil activation GO:0042119 5 5 0,000 0,03274331 0,11916076 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03274331 0,11897252 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03274331 0,11878486 ! response to food GO:0032094 5 5 0,000 0,03274331 0,1185978 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03274331 0,11841132 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03274331 0,11822544 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03274331 0,11804013 ! forebrain neuron development GO:0021884 7 5 0,000 0,03274331 0,1178554 ! melanosome organization GO:0032438 7 5 0,000 0,03274331 0,11767125 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03274331 0,11748768 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03274331 0,11730468 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03274331 0,11712224 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03274331 0,11694038 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03274331 0,11675907 ! nucleoside transport GO:0015858 6 5 0,000 0,03274331 0,11657833 ! nucleoside salvage GO:0043174 7 5 0,000 0,03274331 0,11639815 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03274331 0,11621852 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03274331 0,11603945 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03274331 0,11586093 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03274331 0,11568295 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03274331 0,11550553 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03274331 0,11532864 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03274331 0,1151523 ! depyrimidination GO:0045008 8 5 0,000 0,03274331 0,11497649 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03274331 0,11480122 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03274331 0,11462649 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03274331 0,11445228 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03274331 0,11427861 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03274331 0,11410546 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03274331 0,11393283 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03274331 0,11376073 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03274331 0,11358914 ! monocyte differentiation GO:0030224 8 5 0,000 0,03274331 0,11341808 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03274331 0,11324752 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03274331 0,11307748 ! centrosome duplication GO:0051298 5 5 0,000 0,03274331 0,11290795 ! response to UV-C GO:0010225 6 5 0,000 0,03274331 0,11273893 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03274331 0,11257041 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03274331 0,11240239 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03274331 0,11223488 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03274331 0,11206786 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03274331 0,11190134 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03274331 0,11173532 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03274331 0,11156978 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03274331 0,11140474 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03274331 0,11124018 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03274331 0,11107611 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03274331 0,11091252 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03274331 0,11074942 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03274331 0,11058679 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03274331 0,11042464 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03274331 0,11026296 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03274331 0,11010176 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03274331 0,10994103 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03274331 0,10978076 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03274331 0,10962096 ! histone demethylation GO:0016577 9 5 0,000 0,03274331 0,10946163 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03274331 0,10930276 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03274331 0,10914435 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03274331 0,1089864 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03274331 0,10882891 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03274331 0,10867187 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03274331 0,10851528 ! transcription termination GO:0006353 8 5 0,000 0,03274331 0,10835914 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03274331 0,10820345 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03274331 0,10804821 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03274331 0,10789341 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03274331 0,10773906 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03274331 0,10758515 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03274331 0,10743167 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03274331 0,10727864 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03274331 0,10712603 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03274331 0,10697387 ! apical protein localization GO:0045176 6 5 0,000 0,03274331 0,10682213 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03274331 0,10667083 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03274331 0,10651995 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03274331 0,10636949 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03274331 0,10621947 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03274331 0,10606986 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03274331 0,10592068 ! glial cell migration GO:0008347 10 5 0,000 0,03274331 0,10577191 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03274331 0,10562357 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03274331 0,10547563 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03274331 0,10532812 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03274331 0,10518101 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03274331 0,10503431 ! neural plate development GO:0001840 6 5 0,000 0,03274331 0,10488803 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03274331 0,10474215 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03274331 0,10459667 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03274331 0,1044516 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03274331 0,10430693 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03274331 0,10416266 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03274331 0,10401879 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03274331 0,10387531 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03274331 0,10373223 ! spindle assembly GO:0051225 5 5 0,000 0,03274331 0,10358955 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03274331 0,10344726 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03274331 0,10330535 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03274331 0,10316384 ! organ regeneration GO:0031100 7 5 0,000 0,03274331 0,10302271 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03274331 0,10288197 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03274331 0,10274161 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03274331 0,10260164 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03274331 0,10246204 GO:0055081|anion homeostasis, ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,03302886 0,10321519 ! vesicle organization GO:0016050 79 43 1,000 0,03302886 0,10307514 ! methylation GO:0032259 64 43 1,000 0,03302886 0,10293547 ! regulation of action potential GO:0001508 71 44 1,000 0,0344544 0,1072329 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,0344544 0,10708799 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,03590355 0,11144151 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,03737594 0,11585534 ! histone modification GO:0016570 68 46 1,000 0,03737594 0,11569942 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,03737594 0,11554391 ! respiratory electron transport chain GO:0022904 59 47 1,000 0,03887122 0,1200051 ! endocrine system development GO:0035270 83 47 1,000 0,03887122 0,11984423 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03887122 0,1196838 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,03887122 0,1195238 ! tRNA transcription GO:0009304 11 6 0,000 0,03916327 0,12026105 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03916327 0,1201007 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03916327 0,11994078 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03916327 0,11978129 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03916327 0,11962222 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03916327 0,11946357 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03916327 0,11930534 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03916327 0,11914752 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03916327 0,11899013 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03916327 0,11883315 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03916327 0,11867659 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03916327 0,11852043 ! prostate gland development GO:0030850 9 6 0,000 0,03916327 0,11836469 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03916327 0,11820935 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03916327 0,11805443 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03916327 0,11789991 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03916327 0,11774579 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03916327 0,11759207 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03916327 0,11743876 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03916327 0,11728584 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03916327 0,11713333 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03916327 0,11698121 ! neuron adhesion GO:0007158 9 6 0,000 0,03916327 0,11682948 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03916327 0,11667815 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03916327 0,1165272 ! signal peptide processing GO:0006465 8 6 0,000 0,03916327 0,11637665 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03916327 0,11622649 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03916327 0,11607671 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03916327 0,11592732 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03916327 0,11577831 ! opsonization GO:0008228 8 6 0,000 0,03916327 0,11562969 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03916327 0,11548145 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03916327 0,11533358 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03916327 0,1151861 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03916327 0,11503899 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03916327 0,11489226 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03916327 0,1147459 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03916327 0,11459991 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03916327 0,11445429 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03916327 0,11430905 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03916327 0,11416417 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03916327 0,11401966 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03916327 0,11387551 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03916327 0,11373173 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03916327 0,11358831 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03916327 0,11344525 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03916327 0,11330255 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03916327 0,11316021 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03916327 0,11301823 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03916327 0,1128766 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03916327 0,11273533 ! thymic T cell selection GO:0045061 12 6 0,000 0,03916327 0,11259441 ! protein lipoylation GO:0009249 10 6 0,000 0,03916327 0,11245384 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03916327 0,11231363 ! drug transport GO:0015893 6 6 0,000 0,03916327 0,11217376 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03916327 0,11203424 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03916327 0,11189507 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03916327 0,11175624 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03916327 0,11161776 ! histidine metabolic process GO:0006547 6 6 0,000 0,03916327 0,11147961 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03916327 0,11134181 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03916327 0,11120436 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03916327 0,11106724 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03916327 0,11093045 ! adenohypophysis development GO:0021984 10 6 0,000 0,03916327 0,11079401 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03916327 0,1106579 ! hyperosmotic response GO:0006972 8 6 0,000 0,03916327 0,11052212 ! microtubule nucleation GO:0007020 10 6 0,000 0,03916327 0,11038668 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03916327 0,11025156 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03916327 0,11011678 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03916327 0,10998233 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03916327 0,10984821 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03916327 0,10971441 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,03916327 0,10958093 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03916327 0,10944779 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03916327 0,10931496 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03916327 0,10918246 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03916327 0,10905028 ! purine salvage GO:0043101 8 6 0,000 0,03916327 0,10891841 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03916327 0,10878687 ! neuron apoptosis GO:0051402 8 6 0,000 0,03916327 0,10865564 ! organic alcohol transport GO:0015850 9 6 0,000 0,03916327 0,10852473 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03916327 0,10839414 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03916327 0,10826386 ! male sex determination GO:0030238 9 6 0,000 0,03916327 0,10813389 ! carnitine transport GO:0015879 8 6 0,000 0,03916327 0,10800423 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03916327 0,10787488 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03916327 0,10774585 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03916327 0,10761712 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03916327 0,1074887 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03916327 0,10736058 ! parturition GO:0007567 12 6 0,000 0,03916327 0,10723277 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03916327 0,10710527 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03916327 0,10697806 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03916327 0,10685116 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03916327 0,10672456 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03916327 0,10659826 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03916327 0,10647226 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03916327 0,10634655 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03916327 0,10622114 ! macrophage differentiation GO:0030225 10 6 0,000 0,03916327 0,10609603 ! astrocyte development GO:0014002 14 6 0,000 0,03916327 0,10597121 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03916327 0,10584668 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03916327 0,10572245 ! interaction with symbiont GO:0051702 8 6 0,000 0,03916327 0,10559851 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03916327 0,10547486 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03916327 0,1053515 ! eating behavior GO:0042755 6 6 0,000 0,03916327 0,10522842 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03916327 0,10510563 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03916327 0,10498313 ! response to copper ion GO:0046688 9 6 0,000 0,03916327 0,10486092 ! DNA topological change GO:0006265 8 6 0,000 0,03916327 0,10473899 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03916327 0,10461734 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03916327 0,10449597 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03916327 0,10437489 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03916327 0,10425408 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03916327 0,10413356 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03916327 0,10401331 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03916327 0,10389334 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03916327 0,10377365 ! gas homeostasis GO:0033483 11 6 0,000 0,03916327 0,10365423 ! hair follicle maturation GO:0048820 7 6 0,000 0,03916327 0,10353509 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03916327 0,10341622 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03916327 0,10329762 ! Schwann cell development GO:0014044 14 6 0,000 0,03916327 0,1031793 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03916327 0,10306125 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03916327 0,10294346 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03916327 0,10282595 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03916327 0,1027087 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03916327 0,10259172 ! histone ubiquitination GO:0016574 7 6 0,000 0,03916327 0,102475 ! regulation of meiosis GO:0040020 10 6 0,000 0,03916327 0,10235855 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03916327 0,10224237 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03916327 0,10212645 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03916327 0,10201079 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03916327 0,10189539 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03916327 0,10178026 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03916327 0,10166538 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03916327 0,10155076 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03916327 0,10143641 ! receptor internalization GO:0031623 9 6 0,000 0,03916327 0,1013223 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03916327 0,10120846 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03916327 0,10109487 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,03916327 0,10098153 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03916327 0,10086845 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,03916327 0,10075562 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03916327 0,10064305 ! axonal fasciculation GO:0007413 9 6 0,000 0,03916327 0,10053072 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03916327 0,10041865 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03916327 0,10030682 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03916327 0,10019525 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03916327 0,10008392 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03916327 0,09997284 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03916327 0,099862 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03916327 0,09975142 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03916327 0,09964107 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03916327 0,09953097 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03916327 0,09942111 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03916327 0,0993115 ! adult feeding behavior GO:0008343 6 6 0,000 0,03916327 0,09920212 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03916327 0,09909299 ! blastocyst growth GO:0001832 15 6 0,000 0,03916327 0,0989841 ! pigment granule transport GO:0051904 12 6 0,000 0,03916327 0,09887544 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03916327 0,09876703 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03916327 0,09865885 ! catecholamine transport GO:0051937 7 6 0,000 0,03916327 0,09855091 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03916327 0,0984432 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03916327 0,09833573 ! protein prenylation GO:0018342 10 6 0,000 0,03916327 0,09822849 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03916327 0,09812149 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03916327 0,09801472 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03916327 0,09790818 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03916327 0,09780188 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04038901 0,10075349 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,04038901 0,10064433 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,04038901 0,10053541 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,04038901 0,10042672 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04038901 0,10031827 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,04192896 0,10403085 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,04192896 0,10391875 ! regulation of actin filament length GO:0030832 72 50 1,000 0,04349071 0,10767345 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,04349071 0,10755767 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,04349071 0,10744214 ! positive regulation of growth GO:0045927 67 50 1,000 0,04349071 0,10732686 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,04349071 0,10721182 ! positive regulation of secretion GO:0051047 71 51 1,000 0,04507391 0,11099571 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,04507391 0,110877 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,04507391 0,11075854 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,04507391 0,11064034 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04554099 0,11166768 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04554099 0,11154876 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04554099 0,11143009 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04554099 0,11131168 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04554099 0,11119351 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04554099 0,1110756 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04554099 0,11095793 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04554099 0,11084052 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04554099 0,11072335 ! reproductive behavior GO:0019098 12 7 0,000 0,04554099 0,11060643 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04554099 0,11048975 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,04554099 0,11037333 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04554099 0,11025714 ! oligopeptide transport GO:0006857 11 7 0,000 0,04554099 0,11014121 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04554099 0,11002551 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04554099 0,10991006 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04554099 0,10979485 ! RNA methylation GO:0001510 11 7 0,000 0,04554099 0,10967988 ! pericardium development GO:0060039 8 7 0,000 0,04554099 0,10956515 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04554099 0,10945067 ! fibril organization GO:0043206 13 7 0,000 0,04554099 0,10933642 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04554099 0,10922241 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04554099 0,10910863 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04554099 0,1089951 ! lipoprotein transport GO:0042953 9 7 0,000 0,04554099 0,1088818 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04554099 0,10876873 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04554099 0,1086559 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04554099 0,1085433 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04554099 0,10843094 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04554099 0,10831881 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04554099 0,10820691 ! chemosensory behavior GO:0007635 9 7 0,000 0,04554099 0,10809524 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04554099 0,1079838 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04554099 0,10787259 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04554099 0,10776161 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04554099 0,10765086 ! reflex GO:0060004 12 7 0,000 0,04554099 0,10754034 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04554099 0,10743004 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04554099 0,10731997 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04554099 0,10721012 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04554099 0,1071005 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04554099 0,1069911 ! spinal cord patterning GO:0021511 7 7 0,000 0,04554099 0,10688193 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04554099 0,10677297 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04554099 0,10666424 ! adrenal gland development GO:0030325 17 7 0,000 0,04554099 0,10655574 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04554099 0,10644745 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04554099 0,10633938 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04554099 0,10623153 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04554099 0,1061239 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04554099 0,10601649 ! endosome organization GO:0007032 10 7 0,000 0,04554099 0,10590929 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04554099 0,10580231 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04554099 0,10569555 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04554099 0,105589 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04554099 0,10548267 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04554099 0,10537655 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04554099 0,10527064 ! galactose metabolic process GO:0006012 10 7 0,000 0,04554099 0,10516495 ! vesicle fusion GO:0006906 15 7 0,000 0,04554099 0,10505947 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04554099 0,1049542 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04554099 0,10484914 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04554099 0,10474429 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04554099 0,10463965 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04554099 0,10453522 ! retinol metabolic process GO:0042572 9 7 0,000 0,04554099 0,10443099 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04554099 0,10432698 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04554099 0,10422317 ! rRNA modification GO:0000154 12 7 0,000 0,04554099 0,10411957 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04554099 0,10401617 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04554099 0,10391298 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04554099 0,10381 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04554099 0,10370722 ! intermediate filament organization GO:0045109 11 7 0,000 0,04554099 0,10360464 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04554099 0,10350226 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04554099 0,10340009 ! fibrinolysis GO:0042730 9 7 0,000 0,04554099 0,10329811 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04554099 0,10319634 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04554099 0,10309477 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04554099 0,1029934 ! response to tropane GO:0014073 13 7 0,000 0,04554099 0,10289223 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04554099 0,10279125 ! melanosome localization GO:0032400 10 7 0,000 0,04554099 0,10269048 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04554099 0,1025899 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04554099 0,10248952 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04554099 0,10238933 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04554099 0,10228934 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04554099 0,10218955 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04554099 0,10208995 ! mast cell activation GO:0045576 9 7 0,000 0,04554099 0,10199054 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04554099 0,10189133 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04554099 0,10179231 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04554099 0,10169348 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04554099 0,10159485 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04554099 0,1014964 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04554099 0,10139815 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04554099 0,10130008 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04554099 0,10120221 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04554099 0,10110452 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04554099 0,10100703 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04554099 0,10090972 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04554099 0,1008126 ! response to tumor cell GO:0002347 12 7 0,000 0,04554099 0,10071566 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04554099 0,10061891 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04554099 0,10052235 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04554099 0,10042597 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04554099 0,10032978 ! diuresis GO:0030146 12 7 0,000 0,04554099 0,10023377 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04554099 0,10013794 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04554099 0,1000423 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04554099 0,09994684 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04554099 0,09985156 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04554099 0,09975646 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04554099 0,09966155 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04554099 0,09956681 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04554099 0,09947226 ! lymph node development GO:0048535 9 7 0,000 0,04554099 0,09937788 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04554099 0,09928369 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04554099 0,09918967 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04554099 0,09909583 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04554099 0,09900216 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04554099 0,09890868 ! ATP catabolic process GO:0006200 10 7 0,000 0,04554099 0,09881537 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04554099 0,09872223 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04554099 0,09862927 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04554099 0,09853649 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04554099 0,09844388 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04554099 0,09835144 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04554099 0,09825918 ! muscle adaptation GO:0043500 12 7 0,000 0,04554099 0,09816709 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04554099 0,09807518 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04554099 0,09798343 ! retina homeostasis GO:0001895 9 7 0,000 0,04554099 0,09789186 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04554099 0,09780046 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04554099 0,09770922 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04554099 0,09761816 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04554099 0,09752727 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04554099 0,09743655 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04554099 0,09734599 ! regulation of cellular component size GO:0032535 74 52 1,000 0,04667822 0,09968421 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,04667822 0,09959174 ! establishment of organelle localization GO:0051656 85 52 1,000 0,04667822 0,09949944 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,04830328 0,10286809 ! cell projection assembly GO:0030031 76 53 1,000 0,04830328 0,10277293 ! amino acid transport GO:0006865 84 54 1,000 0,04994876 0,10617574 ! regulation of mitosis GO:0007088 84 54 1,000 0,04994876 0,1060777 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04994876 0,10597984 ! detection of external stimulus GO:0009581 66 54 1,000 0,04994876 0,10588216 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04994876 0,10578467 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05187675 0,1097668 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05187675 0,10966591 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05187675 0,10956521 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05187675 0,10946469 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05187675 0,10936436 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05187675 0,10926421 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05187675 0,10916424 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05187675 0,10906446 ! phosphate transport GO:0006817 10 8 0,000 0,05187675 0,10896485 ! N-glycan processing GO:0006491 12 8 0,000 0,05187675 0,10886543 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05187675 0,10876619 ! UTP metabolic process GO:0046051 8 8 0,000 0,05187675 0,10866714 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05187675 0,10856826 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05187675 0,10846956 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05187675 0,10837104 ! succinate metabolic process GO:0006105 14 8 0,000 0,05187675 0,1082727 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05187675 0,10817454 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05187675 0,10807655 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05187675 0,10797875 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05187675 0,10788112 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05187675 0,10778366 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05187675 0,10768638 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05187675 0,10758928 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05187675 0,10749236 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05187675 0,1073956 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05187675 0,10729902 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05187675 0,10720262 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05187675 0,10710639 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05187675 0,10701033 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05187675 0,10691444 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,05187675 0,10681872 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05187675 0,10672318 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05187675 0,10662781 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05187675 0,1065326 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05187675 0,10643757 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05187675 0,1063427 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05187675 0,10624801 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05187675 0,10615348 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05187675 0,10605912 ! macrophage activation GO:0042116 12 8 0,000 0,05187675 0,10596493 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05187675 0,10587091 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05187675 0,10577705 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05187675 0,10568336 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05187675 0,10558984 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05187675 0,10549648 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05187675 0,10540328 ! ruffle organization GO:0031529 11 8 0,000 0,05187675 0,10531025 ! osteoblast development GO:0002076 13 8 0,000 0,05187675 0,10521738 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05187675 0,10512468 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05187675 0,10503214 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05187675 0,10493977 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05187675 0,10484755 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05187675 0,1047555 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05187675 0,10466361 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05187675 0,10457188 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05187675 0,10448031 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05187675 0,1043889 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05187675 0,10429765 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05187675 0,10420656 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05187675 0,10411563 ! segment specification GO:0007379 10 8 0,000 0,05187675 0,10402486 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05187675 0,10393425 ! cellular extravasation GO:0045123 11 8 0,000 0,05187675 0,10384379 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05187675 0,10375349 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05187675 0,10366335 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05187675 0,10357336 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05187675 0,10348353 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05187675 0,10339386 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05187675 0,10330434 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05187675 0,10321498 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05187675 0,10312577 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05187675 0,10303671 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05187675 0,10294781 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05187675 0,10285906 ! icosanoid secretion GO:0032309 12 8 0,000 0,05187675 0,10277047 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05187675 0,10268203 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05187675 0,10259374 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05187675 0,1025056 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05187675 0,10241761 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05187675 0,10232977 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05187675 0,10224209 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05187675 0,10215455 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05187675 0,10206716 ! sterol catabolic process GO:0016127 9 8 0,000 0,05187675 0,10197993 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05187675 0,10189284 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05187675 0,1018059 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05187675 0,10171911 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05187675 0,10163247 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05187675 0,10154597 ! prophase GO:0051324 11 8 0,000 0,05187675 0,10145962 ! S phase GO:0051320 8 8 0,000 0,05187675 0,10137342 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05187675 0,10128736 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05187675 0,10120145 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05187675 0,10111569 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05187675 0,10103007 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05187675 0,1009446 ! hormone catabolic process GO:0042447 13 8 0,000 0,05187675 0,10085927 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05187675 0,10077408 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05187675 0,10068904 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05187675 0,10060414 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05187675 0,10051939 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05187675 0,10043478 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05187675 0,10035031 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05187675 0,10026598 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05187675 0,10018179 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05187675 0,10009775 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05187675 0,10001384 ! regulation of embryonic development GO:0045995 16 8 0,000 0,05187675 0,09993008 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05187675 0,09984646 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05187675 0,09976297 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,05500435 0,10568923 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,05500435 0,10560101 ! camera-type eye development GO:0043010 88 57 1,000 0,05500435 0,10551293 ! secondary metabolic process GO:0019748 84 57 1,000 0,05500435 0,10542501 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,05500435 0,10533723 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,05672816 0,10854807 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,05672816 0,10845784 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,0581708 0,11112362 ! regulation of developmental growth GO:0048638 13 9 0,000 0,0581708 0,1110314 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,0581708 0,11093934 ! telencephalon cell migration GO:0022029 16 9 0,000 0,0581708 0,11084742 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,0581708 0,11075566 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,0581708 0,11066405 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,0581708 0,11057259 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,0581708 0,11048129 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0581708 0,11039013 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,0581708 0,11029912 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,0581708 0,11020827 ! GTP metabolic process GO:0046039 9 9 0,000 0,0581708 0,11011756 ! elastic fiber assembly GO:0048251 13 9 0,000 0,0581708 0,11002701 ! social behavior GO:0035176 14 9 0,000 0,0581708 0,1099366 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,0581708 0,10984634 ! artery development GO:0060840 19 9 0,000 0,0581708 0,10975623 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,0581708 0,10966626 ! regulation of glycolysis GO:0006110 15 9 0,000 0,0581708 0,10957644 ! response to pain GO:0048265 16 9 0,000 0,0581708 0,10948677 ! protein complex disassembly GO:0043241 17 9 0,000 0,0581708 0,10939725 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,0581708 0,10930787 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,0581708 0,10921864 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,0581708 0,10912956 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,0581708 0,10904062 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,0581708 0,10895182 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,0581708 0,10886317 ! ventral spinal cord development GO:0021517 11 9 0,000 0,0581708 0,10877467 ! protein targeting to ER GO:0045047 19 9 0,000 0,0581708 0,1086863 ! endoderm development GO:0007492 12 9 0,000 0,0581708 0,10859808 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,0581708 0,10851001 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,0581708 0,10842207 ! arginine catabolic process GO:0006527 10 9 0,000 0,0581708 0,10833428 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,0581708 0,10824663 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,0581708 0,10815913 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,0581708 0,10807176 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,0581708 0,10798453 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,0581708 0,10789745 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,0581708 0,10781051 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,0581708 0,1077237 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0581708 0,10763704 ! mannose metabolic process GO:0006013 9 9 0,000 0,0581708 0,10755051 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,0581708 0,10746413 ! receptor clustering GO:0043113 15 9 0,000 0,0581708 0,10737788 ! epithelial cell development GO:0002064 10 9 0,000 0,0581708 0,10729177 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,0581708 0,1072058 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,0581708 0,10711997 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,0581708 0,10703427 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,0581708 0,10694871 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,0581708 0,10686329 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,0581708 0,106778 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,0581708 0,10669285 ! blastoderm segmentation GO:0007350 11 9 0,000 0,0581708 0,10660784 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,0581708 0,10652296 ! DNA ligation GO:0006266 14 9 0,000 0,0581708 0,10643822 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,0581708 0,10635361 ! response to amine stimulus GO:0014075 13 9 0,000 0,0581708 0,10626913 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,0581708 0,10618479 ! erythrocyte development GO:0048821 11 9 0,000 0,0581708 0,10610059 ! renal water homeostasis GO:0003091 14 9 0,000 0,0581708 0,10601651 ! postreplication repair GO:0006301 11 9 0,000 0,0581708 0,10593257 ! mRNA cleavage GO:0006379 13 9 0,000 0,0581708 0,10584876 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,0581708 0,10576509 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,0581708 0,10568155 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,0581708 0,10559814 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,0581708 0,10551486 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,0581708 0,10543171 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,0581708 0,10534869 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,0581708 0,10526581 ! acid secretion GO:0046717 14 9 0,000 0,0581708 0,10518305 ! musculoskeletal movement GO:0050881 11 9 0,000 0,0581708 0,10510042 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,0581708 0,10501793 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,0581708 0,10493556 ! purine base metabolic process GO:0006144 18 9 0,000 0,0581708 0,10485332 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,0581708 0,10477121 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,0581708 0,10468923 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,0581708 0,10460738 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,0581708 0,10452565 ! blastocyst formation GO:0001825 12 9 0,000 0,0581708 0,10444406 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,0581708 0,10436259 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,0581708 0,10428125 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,0581708 0,10420003 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,0581708 0,10411894 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0581708 0,10403798 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,0581708 0,10395714 ! prepulse inhibition GO:0060134 14 9 0,000 0,0581708 0,10387643 ! embryonic placenta development GO:0001892 12 9 0,000 0,0581708 0,10379584 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,0581708 0,10371538 ! insulin secretion GO:0030073 17 9 0,000 0,0581708 0,10363504 ! sequestering of metal ion GO:0051238 11 9 0,000 0,0581708 0,10355483 ! establishment of cell polarity GO:0030010 12 9 0,000 0,0581708 0,10347474 ! nucleus localization GO:0051647 15 9 0,000 0,0581708 0,10339477 ! regulation of synapse organization GO:0050807 12 9 0,000 0,0581708 0,10331493 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,05847074 0,10376752 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,06023177 0,10681039 ! meiosis GO:0007126 96 61 1,000 0,06201092 0,10988068 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,06201092 0,10979609 ! meiotic cell cycle GO:0051321 97 62 1,000 0,0638079 0,11289089 ! organelle localization GO:0051640 96 62 1,000 0,0638079 0,11280412 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06442343 0,11380483 ! neuron fate specification GO:0048665 11 10 0,000 0,06442343 0,11371749 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06442343 0,11363028 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06442343 0,11354321 ! thyroid gland development GO:0030878 19 10 0,000 0,06442343 0,11345627 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06442343 0,11336946 ! synapsis GO:0007129 13 10 0,000 0,06442343 0,11328279 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06442343 0,11319625 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06442343 0,11310984 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06442343 0,11302356 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,06442343 0,11293741 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06442343 0,1128514 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06442343 0,11276551 ! androgen metabolic process GO:0008209 13 10 0,000 0,06442343 0,11267976 ! phospholipid efflux GO:0033700 16 10 0,000 0,06442343 0,11259414 ! hippocampus development GO:0021766 19 10 0,000 0,06442343 0,11250864 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06442343 0,11242328 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06442343 0,11233805 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06442343 0,11225294 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06442343 0,11216797 ! pathogenesis GO:0009405 13 10 0,000 0,06442343 0,11208312 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06442343 0,1119984 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06442343 0,11191381 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06442343 0,11182935 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06442343 0,11174501 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06442343 0,1116608 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06442343 0,11157672 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06442343 0,11149277 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06442343 0,11140894 ! response to X-ray GO:0010165 16 10 0,000 0,06442343 0,11132523 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06442343 0,11124166 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06442343 0,1111582 ! forebrain cell migration GO:0021885 17 10 0,000 0,06442343 0,11107488 ! lipid digestion GO:0044241 15 10 0,000 0,06442343 0,11099167 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06442343 0,1109086 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06442343 0,11082564 ! UV protection GO:0009650 14 10 0,000 0,06442343 0,11074281 ! entry into host cell GO:0030260 20 10 0,000 0,06442343 0,11066011 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06442343 0,11057753 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06442343 0,11049507 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,06442343 0,11041273 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06442343 0,11033052 ! regulation of organ growth GO:0046620 11 10 0,000 0,06442343 0,11024843 ! response to dsRNA GO:0043331 18 10 0,000 0,06442343 0,11016646 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06442343 0,11008461 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06442343 0,11000288 ! embryonic axis specification GO:0000578 12 10 0,000 0,06442343 0,10992128 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06442343 0,1098398 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06442343 0,10975843 ! cranial nerve development GO:0021545 12 10 0,000 0,06442343 0,10967719 ! fucose catabolic process GO:0019317 16 10 0,000 0,06442343 0,10959607 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06442343 0,10951507 ! protein sumoylation GO:0016925 12 10 0,000 0,06442343 0,10943418 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06442343 0,10935342 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06442343 0,10927278 ! zymogen activation GO:0031638 14 10 0,000 0,06442343 0,10919225 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06442343 0,10911184 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06442343 0,10903156 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06442343 0,10895139 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06442343 0,10887133 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06442343 0,1087914 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06442343 0,10871158 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06442343 0,10863188 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,06442343 0,1085523 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06442343 0,10847283 ! detection of bacterium GO:0016045 10 10 0,000 0,06442343 0,10839348 ! embryonic gut development GO:0048566 11 10 0,000 0,06442343 0,10831424 ! activation of innate immune response GO:0002218 10 10 0,000 0,06442343 0,10823512 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06442343 0,10815612 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06442343 0,10807723 ! developmental induction GO:0031128 13 10 0,000 0,06442343 0,10799846 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06442343 0,1079198 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06442343 0,10784126 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06442343 0,10776283 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06442343 0,10768451 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,06562237 0,1096089 ! regulation of lipase activity GO:0060191 109 63 1,000 0,06562237 0,10952936 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,06745405 0,11250494 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,06745405 0,11242341 ! adaptive immune response GO:0002250 94 64 1,000 0,06745405 0,11234201 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,06930262 0,11533721 ! defense response to bacterium GO:0042742 73 65 1,000 0,06930262 0,11525382 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,06930262 0,11517054 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,06930262 0,11508738 ! protein oligomerization GO:0051259 100 65 1,000 0,06930262 0,11500435 ! rRNA transcription GO:0009303 17 11 0,000 0,0706349 0,1171307 ! respiratory burst GO:0045730 14 11 0,000 0,0706349 0,11704631 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,0706349 0,11696204 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,0706349 0,1168779 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,0706349 0,11679387 ! virus-host interaction GO:0019048 17 11 0,000 0,0706349 0,11670997 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,0706349 0,11662619 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,0706349 0,11654252 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,0706349 0,11645898 ! RNA polyadenylation GO:0043631 19 11 0,000 0,0706349 0,11637556 ! mating GO:0007618 14 11 0,000 0,0706349 0,11629225 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,0706349 0,11620907 ! T cell proliferation GO:0042098 20 11 0,000 0,0706349 0,116126 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,0706349 0,11604305 ! bone resorption GO:0045453 16 11 0,000 0,0706349 0,11596023 ! regulated secretory pathway GO:0045055 14 11 0,000 0,0706349 0,11587752 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,0706349 0,11579492 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,0706349 0,11571245 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,0706349 0,11563009 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,0706349 0,11554785 ! syncytium formation GO:0006949 15 11 0,000 0,0706349 0,11546573 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,0706349 0,11538372 ! mitotic spindle organization GO:0007052 15 11 0,000 0,0706349 0,11530183 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,0706349 0,11522005 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,0706349 0,1151384 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,0706349 0,11505685 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,0706349 0,11497543 ! adult heart development GO:0007512 11 11 0,000 0,0706349 0,11489411 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,0706349 0,11481292 ! temperature homeostasis GO:0001659 16 11 0,000 0,0706349 0,11473183 ! L-glutamate transport GO:0015813 16 11 0,000 0,0706349 0,11465087 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,0706349 0,11457001 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,0706349 0,11448927 ! stem cell development GO:0048864 29 11 0,000 0,0706349 0,11440865 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,0706349 0,11432813 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,0706349 0,11424773 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,0706349 0,11416745 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,0706349 0,11408727 ! vasoconstriction GO:0042310 15 11 0,000 0,0706349 0,11400721 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,0706349 0,11392726 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,0706349 0,11384743 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,0706349 0,1137677 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,0706349 0,11368809 ! ribosome assembly GO:0042255 13 11 0,000 0,0706349 0,11360858 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,0706349 0,11352919 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,0706349 0,11344991 ! chromatin silencing GO:0006342 19 11 0,000 0,0706349 0,11337074 ! nucleosome positioning GO:0016584 13 11 0,000 0,0706349 0,11329169 ! regulation of isotype switching GO:0045191 19 11 0,000 0,0706349 0,11321274 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,0706349 0,1131339 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,0706349 0,11305517 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,0706349 0,11297655 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,0706349 0,11289804 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,0706349 0,11281964 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,0706349 0,11274134 ! male genitalia development GO:0030539 13 11 0,000 0,0706349 0,11266316 ! cholesterol efflux GO:0033344 19 11 0,000 0,0706349 0,11258508 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,0706349 0,11250712 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,0706349 0,11242926 ! germ cell migration GO:0008354 18 11 0,000 0,0706349 0,11235151 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,0706349 0,11227386 ! defense response to fungus GO:0050832 12 11 0,000 0,0706349 0,11219632 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,0706349 0,11211889 ! lysogeny GO:0030069 18 11 0,000 0,0706349 0,11204157 GO:0019047|provirus integration, ! acrosome reaction GO:0007340 13 11 0,000 0,0706349 0,11196435 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,0706349 0,11188724 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,07116779 0,11265376 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,07116779 0,11257628 ! axon guidance GO:0007411 99 66 1,000 0,07116779 0,11249891 ! regulation of immune effector process GO:0002697 101 66 1,000 0,07116779 0,11242164 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,07304925 0,11531454 ! acute inflammatory response GO:0002526 92 68 1,000 0,07494672 0,11822871 ! learning or memory GO:0007611 123 68 1,000 0,07494672 0,11814768 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,07494672 0,11806675 ! rhythmic process GO:0048511 105 68 1,000 0,07494672 0,11798594 ! lactation GO:0007595 20 12 0,000 0,07680549 0,12082943 ! reproductive cellular process GO:0048610 14 12 0,000 0,07680549 0,12074684 ! tRNA modification GO:0006400 14 12 0,000 0,07680549 0,12066436 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,07680549 0,120582 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07680549 0,12049975 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,07680549 0,12041761 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07680549 0,12033558 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07680549 0,12025366 ! non-recombinational repair GO:0000726 19 12 0,000 0,07680549 0,12017186 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07680549 0,12009016 ! peroxisomal transport GO:0043574 21 12 0,000 0,07680549 0,12000858 ! cartilage condensation GO:0001502 18 12 0,000 0,07680549 0,11992711 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,07680549 0,11984575 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07680549 0,11976449 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,07680549 0,11968335 ! heart looping GO:0001947 15 12 0,000 0,07680549 0,11960232 ! palate development GO:0060021 15 12 0,000 0,07680549 0,1195214 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,07680549 0,11944059 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07680549 0,11935989 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07680549 0,11927929 ! arginine metabolic process GO:0006525 13 12 0,000 0,07680549 0,11919881 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07680549 0,11911843 ! methionine metabolic process GO:0006555 13 12 0,000 0,07680549 0,11903816 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07680549 0,118958 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,07680549 0,11887795 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07680549 0,118798 ! monoamine transport GO:0015844 13 12 0,000 0,07680549 0,11871817 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07680549 0,11863844 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,07680549 0,11855881 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07680549 0,1184793 ! L-amino acid transport GO:0015807 20 12 0,000 0,07680549 0,11839989 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07680549 0,11832058 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07680549 0,11824139 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07680549 0,11816229 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07680549 0,11808331 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07680549 0,11800443 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07680549 0,11792565 ! cerebellum development GO:0021549 13 12 0,000 0,07680549 0,11784698 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07680549 0,11776842 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,07680549 0,11768996 ! histone methylation GO:0016571 15 12 0,000 0,07680549 0,1176116 ! autonomic nervous system development GO:0048483 23 12 0,000 0,07680549 0,11753335 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07680549 0,11745521 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07680549 0,11737716 ! regulation of epidermis development GO:0045682 17 12 0,000 0,07680549 0,11729922 ! intestinal absorption GO:0050892 19 12 0,000 0,07680549 0,11722139 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07680549 0,11714365 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07680549 0,11706602 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,07680549 0,1169885 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07680549 0,11691107 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,07680549 0,11683375 ! microspike assembly GO:0030035 23 12 0,000 0,07680549 0,11675653 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07680549 0,11667941 ! response to cold GO:0009409 14 12 0,000 0,07680549 0,1166024 ! amine transport GO:0015837 101 70 1,000 0,07878851 0,11953402 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,08073226 0,12240224 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,08073226 0,12232161 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08293546 0,12557706 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08293546 0,12549445 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08293546 0,12541194 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,08293546 0,12532954 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08293546 0,12524725 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08293546 0,12516507 ! lipid localization GO:0010876 24 13 0,000 0,08293546 0,12508299 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08293546 0,12500102 ! organelle fusion GO:0048284 28 13 0,000 0,08293546 0,12491916 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08293546 0,12483741 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08293546 0,12475576 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08293546 0,12467422 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08293546 0,12459279 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08293546 0,12451146 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08293546 0,12443024 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08293546 0,12434913 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08293546 0,12426812 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08293546 0,12418721 ! NAD metabolic process GO:0019674 21 13 0,000 0,08293546 0,12410641 ! bone mineralization GO:0030282 15 13 0,000 0,08293546 0,12402572 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08293546 0,12394513 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08293546 0,12386465 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08293546 0,12378427 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08293546 0,12370399 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08293546 0,12362382 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,08293546 0,12354376 ! genitalia development GO:0048806 15 13 0,000 0,08293546 0,12346379 ! regulation of cellular pH GO:0030641 20 13 0,000 0,08293546 0,12338393 ! tissue regeneration GO:0042246 21 13 0,000 0,08293546 0,12330418 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,08293546 0,12322452 ! cofactor transport GO:0051181 19 13 0,000 0,08293546 0,12314497 ! NADP metabolic process GO:0006739 18 13 0,000 0,08293546 0,12306552 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08293546 0,12298618 ! gas transport GO:0015669 18 13 0,000 0,08293546 0,12290693 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08293546 0,12282779 ! regulation of axon extension GO:0030516 23 13 0,000 0,08293546 0,12274875 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08293546 0,12266981 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08293546 0,12259098 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08293546 0,12251224 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08293546 0,12243361 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08293546 0,12235507 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,08466406 0,12482522 ! protein import into nucleus GO:0006606 118 74 1,000 0,08665155 0,12767366 ! response to nutrient GO:0007584 104 75 1,000 0,08865308 0,13053911 ! nuclear import GO:0051170 121 75 1,000 0,08865308 0,13045559 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,08902508 0,13091923 ! superoxide anion generation GO:0042554 18 14 0,000 0,08902508 0,13083557 ! neuron maturation GO:0042551 21 14 0,000 0,08902508 0,13075203 ! regulation of S phase GO:0033261 18 14 0,000 0,08902508 0,13066859 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08902508 0,13058525 ! myotube differentiation GO:0014902 21 14 0,000 0,08902508 0,13050202 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,08902508 0,1304189 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08902508 0,13033588 ! inositol metabolic process GO:0006020 20 14 0,000 0,08902508 0,13025297 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08902508 0,13017017 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08902508 0,13008747 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08902508 0,13000487 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08902508 0,12992238 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08902508 0,12984 ! response to cAMP GO:0051591 19 14 0,000 0,08902508 0,12975771 ! limbic system development GO:0021761 25 14 0,000 0,08902508 0,12967554 ! startle response GO:0001964 21 14 0,000 0,08902508 0,12959346 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08902508 0,1295115 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08902508 0,12942963 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,08902508 0,12934787 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08902508 0,12926621 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08902508 0,12918465 ! glycine metabolic process GO:0006544 22 14 0,000 0,08902508 0,1291032 ! pituitary gland development GO:0021983 23 14 0,000 0,08902508 0,12902185 ! cellular response to starvation GO:0009267 21 14 0,000 0,08902508 0,1289406 ! lysosomal transport GO:0007041 20 14 0,000 0,08902508 0,12885946 ! regulation of heart rate GO:0002027 23 14 0,000 0,08902508 0,12877841 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08902508 0,12869747 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08902508 0,12861663 ! embryo implantation GO:0007566 27 14 0,000 0,08902508 0,12853589 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,08902508 0,12845525 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,08902508 0,12837472 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08902508 0,12829428 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08902508 0,12821395 ! axon cargo transport GO:0008088 27 14 0,000 0,08902508 0,12813371 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08902508 0,12805358 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08902508 0,12797355 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08902508 0,12789361 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08902508 0,12781378 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08902508 0,12773404 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08902508 0,12765441 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08902508 0,12757487 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08902508 0,12749544 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08902508 0,1274161 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,08902508 0,12733686 ! muscle maintenance GO:0046716 19 14 0,000 0,08902508 0,12725772 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08902508 0,12717868 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08902508 0,12709974 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08902508 0,12702089 ! cell killing GO:0001906 20 14 0,000 0,08902508 0,12694214 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,08902508 0,12686349 ! cilium assembly GO:0042384 20 14 0,000 0,08902508 0,12678494 ! tRNA metabolic process GO:0006399 95 76 1,000 0,09066837 0,12904533 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,09066837 0,12896552 ! protein ubiquitination GO:0016567 125 77 1,000 0,09269715 0,13176975 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,09269715 0,13168836 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,0950746 0,13498246 ! positive regulation of cell size GO:0045793 20 15 0,000 0,0950746 0,13489919 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,0950746 0,13481602 ! skin development GO:0043588 25 15 0,000 0,0950746 0,13473295 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,0950746 0,13464999 ! lipid phosphorylation GO:0046834 23 15 0,000 0,0950746 0,13456713 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,0950746 0,13448437 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,0950746 0,13440171 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,0950746 0,13431915 ! bile acid metabolic process GO:0008206 22 15 0,000 0,0950746 0,1342367 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,0950746 0,13415434 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,0950746 0,13407209 ! adult walking behavior GO:0007628 25 15 0,000 0,0950746 0,13398994 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,0950746 0,13390789 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,0950746 0,13382594 ! myoblast differentiation GO:0045445 27 15 0,000 0,0950746 0,13374409 ! centrosome cycle GO:0007098 16 15 0,000 0,0950746 0,13366234 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,0950746 0,13358068 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,0950746 0,13349913 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,0950746 0,13341768 ! cerebral cortex development GO:0021987 29 15 0,000 0,0950746 0,13333633 ! response to osmotic stress GO:0006970 22 15 0,000 0,0950746 0,13325508 ! vesicle coating GO:0006901 25 15 0,000 0,0950746 0,13317392 ! DNA integration GO:0015074 22 15 0,000 0,0950746 0,13309287 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,0950746 0,13301191 ! regulation of vasodilation GO:0042312 24 15 0,000 0,0950746 0,13293105 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,0950746 0,13285029 ! neuron recognition GO:0008038 22 15 0,000 0,0950746 0,13276963 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,0950746 0,13268907 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,0950746 0,1326086 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,0950746 0,13252823 ! biomineral formation GO:0031214 18 15 0,000 0,0950746 0,13244796 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,0950746 0,13236778 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,0950746 0,13228771 ! dopamine metabolic process GO:0042417 30 15 0,000 0,0950746 0,13220773 ! organic cation transport GO:0015695 19 15 0,000 0,0950746 0,13212784 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,0950746 0,13204806 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,0950746 0,13196836 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,0950746 0,13188877 ! peptide hormone processing GO:0016486 19 15 0,000 0,0950746 0,13180927 ! cellular respiration GO:0045333 107 79 1,000 0,09679415 0,13411238 ! oxidative phosphorylation GO:0006119 105 79 1,000 0,09679415 0,13403164 ! protein localization in nucleus GO:0034504 133 80 1,000 0,09886185 0,13681243 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,09886185 0,13673016 ! mRNA transport GO:0051028 121 81 1,000 0,10094201 0,1395232 ! response to protein stimulus GO:0051789 111 81 1,000 0,10094201 0,13943941 ! protein secretion GO:0009306 27 16 0,000 0,1010843 0,13955215 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,1010843 0,13946843 ! bone remodeling GO:0046849 24 16 0,000 0,1010843 0,13938482 ! endothelial cell migration GO:0043542 22 16 0,000 0,1010843 0,13930131 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,1010843 0,13921789 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,1010843 0,13913458 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,1010843 0,13905136 ! glial cell development GO:0021782 24 16 0,000 0,1010843 0,13896825 ! patterning of blood vessels GO:0001569 24 16 0,000 0,1010843 0,13888523 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,1010843 0,13880232 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,1010843 0,1387195 ! protein polyubiquitination GO:0000209 26 16 0,000 0,1010843 0,13863678 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,1010843 0,13855416 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,1010843 0,13847164 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,1010843 0,13838921 ! fructose metabolic process GO:0006000 20 16 0,000 0,1010843 0,13830689 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,1010843 0,13822466 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,1010843 0,13814253 ! protein export from nucleus GO:0006611 24 16 0,000 0,1010843 0,1380605 ! negative regulation of immune response GO:0050777 28 16 0,000 0,1010843 0,13797856 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,1010843 0,13789673 ! DNA replication initiation GO:0006270 25 16 0,000 0,1010843 0,13781498 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,1010843 0,13773334 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,1010843 0,13765179 ! diencephalon development GO:0021536 25 16 0,000 0,1010843 0,13757034 ! neural crest cell migration GO:0001755 24 16 0,000 0,1010843 0,13748899 ! G1 phase GO:0051318 27 16 0,000 0,1010843 0,13740773 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,1010843 0,13732657 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,1010843 0,1372455 ! steroid catabolic process GO:0006706 22 16 0,000 0,1010843 0,13716453 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,1010843 0,13708366 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,1010843 0,13700288 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,1010843 0,13692219 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,1010843 0,1368416 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,1010843 0,13676111 ! sperm-egg recognition GO:0035036 16 16 0,000 0,1010843 0,1366807 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,1010843 0,1366004 ! nerve development GO:0021675 18 16 0,000 0,1010843 0,13652019 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,1010843 0,13644007 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,1010843 0,13636005 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,10705442 0,14432894 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,10705442 0,14424439 ! negative regulation of defense response GO:0031348 19 17 0,000 0,10705442 0,14415994 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,10705442 0,14407558 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,10705442 0,14399133 ! glycerol metabolic process GO:0006071 20 17 0,000 0,10705442 0,14390717 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,10705442 0,14382311 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,10705442 0,14373915 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,10705442 0,14365529 ! signal complex assembly GO:0007172 29 17 0,000 0,10705442 0,14357153 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,10705442 0,14348786 ! memory GO:0007613 25 17 0,000 0,10705442 0,14340429 ! keratinization GO:0031424 17 17 0,000 0,10705442 0,14332082 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,10705442 0,14323745 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,10705442 0,14315417 ! retinoid metabolic process GO:0001523 22 17 0,000 0,10705442 0,14307099 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,10705442 0,1429879 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,10705442 0,14290492 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,10705442 0,14282202 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,10705442 0,14273923 ! membrane budding GO:0006900 29 17 0,000 0,10705442 0,14265653 ! heme metabolic process GO:0042168 27 17 0,000 0,10705442 0,14257393 ! actin filament bundle formation GO:0051017 26 17 0,000 0,10705442 0,14249142 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,10705442 0,142409 ! body fluid secretion GO:0007589 27 17 0,000 0,10705442 0,14232669 ! stem cell differentiation GO:0048863 36 17 0,000 0,10705442 0,14224447 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,10705442 0,14216234 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,10705442 0,14208031 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,10705442 0,14199837 ! sensory perception of pain GO:0019233 23 17 0,000 0,10705442 0,14191652 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,10705442 0,14183477 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,10705442 0,14175312 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,10705442 0,14167156 ! synaptogenesis GO:0007416 24 17 0,000 0,10705442 0,14159009 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,10705442 0,14150872 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,10705442 0,14142744 ! cell-cell junction organization GO:0045216 25 17 0,000 0,10705442 0,14134625 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,10705442 0,14126516 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,10705442 0,14118416 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,10705442 0,14110325 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,10938217 0,14408877 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,10938217 0,1440063 ! rRNA metabolic process GO:0016072 107 85 1,000 0,10938217 0,14392391 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,10938217 0,14384162 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,11298524 0,14849488 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,11298524 0,14841008 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,11298524 0,14832537 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,11298524 0,14824076 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,11298524 0,14815624 ! cAMP metabolic process GO:0046058 33 18 0,000 0,11298524 0,14807182 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,11298524 0,1479875 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,11298524 0,14790327 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,11298524 0,14781914 ! axis specification GO:0009798 26 18 0,000 0,11298524 0,1477351 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,11298524 0,14765116 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,11298524 0,14756732 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,11298524 0,14748357 ! glutamine metabolic process GO:0006541 23 18 0,000 0,11298524 0,14739991 ! response to retinoic acid GO:0032526 25 18 0,000 0,11298524 0,14731635 ! central nervous system neuron development GO:0021954 30 18 0,000 0,11298524 0,14723289 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,11298524 0,14714952 ! fucose metabolic process GO:0006004 26 18 0,000 0,11298524 0,14706624 ! response to fungus GO:0009620 19 18 0,000 0,11298524 0,14698306 ! peptide cross-linking GO:0018149 31 18 0,000 0,11298524 0,14689997 ! heart process GO:0003015 27 18 0,000 0,11298524 0,14681697 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,11298524 0,14673407 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,11298524 0,14665127 ! visual learning GO:0008542 35 18 0,000 0,11298524 0,14656855 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,11298524 0,14648593 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,11298524 0,14640341 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,11298524 0,14632097 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,11298524 0,14623863 ! vitamin transport GO:0051180 24 18 0,000 0,11298524 0,14615638 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,11298524 0,14607422 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,11298524 0,14599216 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,11298524 0,14591019 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,11298524 0,14582831 ! cell-cell recognition GO:0009988 20 18 0,000 0,11298524 0,14574652 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,11298524 0,14566482 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,11298524 0,14558322 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,11298524 0,1455017 ! cellular defense response GO:0006968 102 87 1,000 0,11367055 0,14630234 ! female pregnancy GO:0007565 130 87 1,000 0,11367055 0,14622051 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,11583098 0,1489163 ! establishment of RNA localization GO:0051236 128 88 1,000 0,11583098 0,1488331 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,11583098 0,14875 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,11800192 0,15145335 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,118877 0,15249141 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,118877 0,15240641 ! positive regulation of ossification GO:0045778 30 19 0,000 0,118877 0,1523215 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,118877 0,15223669 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,118877 0,15215197 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,118877 0,15206735 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,118877 0,15198282 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,118877 0,15189839 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,118877 0,15181404 ! sensory perception of taste GO:0050909 23 19 0,000 0,118877 0,1517298 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,118877 0,15164564 ! smooth muscle contraction GO:0006939 36 19 0,000 0,118877 0,15156158 ! peroxisome organization GO:0007031 29 19 0,000 0,118877 0,15147761 ! digestive system process GO:0022600 30 19 0,000 0,118877 0,15139374 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,118877 0,15130996 ! response to vitamin A GO:0033189 26 19 0,000 0,118877 0,15122627 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,118877 0,15114267 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,118877 0,15105917 ! response to starvation GO:0042594 30 19 0,000 0,118877 0,15097576 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,118877 0,15089244 ! plasma membrane fusion GO:0045026 23 19 0,000 0,118877 0,15080921 ! cytolysis GO:0019835 20 19 0,000 0,118877 0,15072607 ! vasodilation GO:0042311 33 19 0,000 0,118877 0,15064303 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,118877 0,15056007 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,118877 0,15047721 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,118877 0,15039444 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,118877 0,15031176 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,118877 0,15022917 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,118877 0,15014667 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,118877 0,15006427 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,118877 0,14998195 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,118877 0,14989972 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,118877 0,14981759 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,118877 0,14973554 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,118877 0,14965358 ! protein stabilization GO:0050821 26 19 0,000 0,118877 0,14957171 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,12018313 0,15113242 ! RNA localization GO:0006403 135 91 1,000 0,1223744 0,15380389 ! cell fate commitment GO:0045165 141 92 1,000 0,12457548 0,15648477 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,12472996 0,15659329 ! iron ion transport GO:0006826 37 20 0,000 0,12472996 0,15650786 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,12472996 0,15642252 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,12472996 0,15633728 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,12472996 0,15625213 ! response to vitamin GO:0033273 29 20 0,000 0,12472996 0,15616707 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,12472996 0,1560821 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,12472996 0,15599723 ! spinal cord development GO:0021510 31 20 0,000 0,12472996 0,15591245 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,12472996 0,15582776 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,12472996 0,15574316 ! chromosome condensation GO:0030261 31 20 0,000 0,12472996 0,15565866 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,12472996 0,15557424 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,12472996 0,15548992 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,12472996 0,15540569 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,12472996 0,15532155 ! pallium development GO:0021543 38 20 0,000 0,12472996 0,1552375 ! collagen fibril organization GO:0030199 45 20 0,000 0,12472996 0,15515355 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,12472996 0,15506968 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,12472996 0,1549859 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,12472996 0,15490222 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,12472996 0,15481862 ! alditol metabolic process GO:0019400 24 20 0,000 0,12472996 0,15473512 ! actin filament-based movement GO:0030048 34 20 0,000 0,12472996 0,1546517 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,12678617 0,15711649 ! electron transport chain GO:0022900 123 94 1,000 0,12900624 0,15978156 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,13054437 0,1615996 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,13054437 0,16151267 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,13054437 0,16142584 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,13054437 0,1613391 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13054437 0,16125245 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13054437 0,16116589 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,13054437 0,16107943 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,13054437 0,16099306 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,13054437 0,16090679 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,13054437 0,1608206 ! vesicle docking GO:0048278 27 21 0,000 0,13054437 0,16073451 ! phototransduction GO:0007602 25 21 0,000 0,13054437 0,16064851 ! visual behavior GO:0007632 39 21 0,000 0,13054437 0,1605626 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,13054437 0,16047678 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13054437 0,16039106 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,13054437 0,16030543 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,13054437 0,16021988 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,13054437 0,16013443 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,13054437 0,16004907 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13054437 0,1599638 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,13054437 0,15987863 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13054437 0,15979354 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,13054437 0,15970854 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13054437 0,15962364 ! fatty acid transport GO:0015908 30 21 0,000 0,13054437 0,15953882 ! immunoglobulin production GO:0002377 33 21 0,000 0,13054437 0,1594541 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13054437 0,15936946 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,13054437 0,15928491 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,13054437 0,15920046 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13054437 0,15911609 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13054437 0,15903181 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13054437 0,15894762 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,13054437 0,15886352 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,13054437 0,15877951 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,13054437 0,15869559 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13054437 0,15861176 ! carboxylic acid transport GO:0046942 147 95 1,000 0,13123547 0,15936725 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 1,000 0,13347364 0,16199967 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,13347364 0,16191422 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,13347364 0,16182887 ! protein maturation GO:0051604 129 96 1,000 0,13347364 0,16174361 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,1363205 0,16510645 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,1363205 0,16501955 ! viral genome replication GO:0019079 29 22 0,000 0,1363205 0,16493274 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,1363205 0,16484603 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,1363205 0,1647594 ! leukocyte adhesion GO:0007159 38 22 0,000 0,1363205 0,16467287 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,1363205 0,16458643 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,1363205 0,16450007 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,1363205 0,16441381 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,1363205 0,16432764 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,1363205 0,16424156 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,1363205 0,16415557 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,1363205 0,16406967 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,1363205 0,16398386 ! lysosome organization GO:0007040 37 22 0,000 0,1363205 0,16389814 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,1363205 0,16381251 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,1363205 0,16372697 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,1363205 0,16364151 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,1363205 0,16355615 ! membrane depolarization GO:0051899 35 22 0,000 0,1363205 0,16347088 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,1363205 0,16338569 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,1363205 0,16330059 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,1363205 0,16321559 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,1363205 0,16313067 ! blastocyst development GO:0001824 37 22 0,000 0,1363205 0,16304583 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,1363205 0,16296109 ! protein tetramerization GO:0051262 39 22 0,000 0,1363205 0,16287644 ! extracellular structure organization GO:0043062 156 99 1,000 0,14023968 0,1674721 ! protein import GO:0017038 156 99 1,000 0,14023968 0,1673852 ! neuron fate commitment GO:0048663 32 23 0,000 0,14205857 0,16946821 ! embryonic pattern specification GO:0009880 31 23 0,000 0,14205857 0,16938036 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,14205857 0,1692926 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,14205857 0,16920493 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,14205857 0,16911735 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,14205857 0,16902986 ! vesicle targeting GO:0006903 32 23 0,000 0,14205857 0,16894246 ! osteoblast differentiation GO:0001649 40 23 0,000 0,14205857 0,16885515 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,14205857 0,16876793 ! interaction with host GO:0051701 37 23 0,000 0,14205857 0,1686808 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,14205857 0,16859377 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,14205857 0,16850682 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,14205857 0,16841996 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,14205857 0,16833319 ! cell fate determination GO:0001709 45 23 0,000 0,14205857 0,16824651 ! pentose metabolic process GO:0019321 31 23 0,000 0,14205857 0,16815992 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,14205857 0,16807341 ! spermatid development GO:0007286 33 23 0,000 0,14205857 0,167987 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,14205857 0,16790068 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,14205857 0,16781444 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,14205857 0,16772829 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,14205857 0,16764224 ! telomere organization GO:0032200 32 23 0,000 0,14205857 0,16755627 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,14205857 0,16747038 ! regulation of amine transport GO:0051952 38 23 0,000 0,14205857 0,16738459 ! liver development GO:0001889 40 23 0,000 0,14205857 0,16729888 ! protein localization in organelle GO:0033365 161 100 1,000 0,14251151 0,16774641 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,14775885 0,17383395 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,14775885 0,17374507 ! initiation of viral infection GO:0019059 42 24 0,000 0,14775885 0,17365629 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,14775885 0,1735676 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,14775885 0,173479 ! superoxide metabolic process GO:0006801 32 24 0,000 0,14775885 0,17339049 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,14775885 0,17330207 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,14775885 0,17321374 ! fat cell differentiation GO:0045444 37 24 0,000 0,14775885 0,1731255 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,14775885 0,17303735 ! sperm motility GO:0030317 27 24 0,000 0,14775885 0,17294929 ! vacuole organization GO:0007033 39 24 0,000 0,14775885 0,17286132 ! receptor metabolic process GO:0043112 37 24 0,000 0,14775885 0,17277344 ! neural crest cell development GO:0014032 39 24 0,000 0,14775885 0,17268565 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 56 24 0,000 0,14775885 0,17259795 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 0,000 0,14775885 0,17251034 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,14775885 0,17242281 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,14775885 0,17233538 ! glutathione metabolic process GO:0006749 29 24 0,000 0,14775885 0,17224803 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,14775885 0,17216077 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,15342159 0,17866818 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,15342159 0,17857776 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,15342159 0,17848743 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,15342159 0,17839719 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,15342159 0,17830705 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,15342159 0,17821699 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,15342159 0,17812703 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,15342159 0,17803716 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,15342159 0,17794738 ! phospholipid transport GO:0015914 35 25 0,000 0,15342159 0,17785768 ! detection of light stimulus GO:0009583 30 25 0,000 0,15342159 0,17776808 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,15904701 0,18419342 ! translational initiation GO:0006413 43 26 0,000 0,15904701 0,18410072 ! regulation of pH GO:0006885 36 26 0,000 0,15904701 0,18400811 ! circadian rhythm GO:0007623 42 26 0,000 0,15904701 0,1839156 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,15904701 0,18382318 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,15904701 0,18373085 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,15904701 0,18363862 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,15904701 0,18354648 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,15904701 0,18345443 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,15904701 0,18336247 ! regulation of coagulation GO:0050818 39 26 0,000 0,15904701 0,18327061 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,16463538 0,18961511 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,16463538 0,18952021 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,16463538 0,1894254 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,16463538 0,18933069 ! membrane docking GO:0022406 39 27 0,000 0,16463538 0,18923607 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,16463538 0,18914155 ! catechol metabolic process GO:0009712 43 27 0,000 0,16463538 0,18904712 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,16463538 0,18895278 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,16463538 0,18885854 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,16463538 0,1887644 ! natural killer cell activation GO:0030101 35 27 0,000 0,16463538 0,18867034 ! lipid oxidation GO:0034440 38 27 0,000 0,16463538 0,18857638 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,16463538 0,18848252 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,16463538 0,18838874 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,16463538 0,18829507 ! gene silencing GO:0016458 41 27 0,000 0,16463538 0,18820148 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,17018693 0,19445104 ! phenol metabolic process GO:0018958 44 28 0,000 0,17018693 0,19435449 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,17018693 0,19425803 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,17018693 0,19416168 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,17018693 0,19406541 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,17018693 0,19396925 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,17018693 0,19387318 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,17018693 0,1937772 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,17018693 0,19368132 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,17018693 0,19358553 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,17018693 0,19348984 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,17018693 0,19339424 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,17018693 0,19329874 ! mesoderm formation GO:0001707 46 28 0,000 0,17018693 0,19320333 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,17018693 0,19310801 ! BMP signaling pathway GO:0030509 40 28 0,000 0,17018693 0,19301279 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,17018693 0,19291766 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,17018693 0,19282263 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,17018693 0,19272769 ! placenta development GO:0001890 37 28 0,000 0,17018693 0,19263284 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1757019 0,19877736 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1757019 0,19867963 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1757019 0,198582 ! mismatch repair GO:0006298 34 29 0,000 0,1757019 0,19848447 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,1757019 0,19838703 ! formation of primary germ layer GO:0001704 48 29 0,000 0,1757019 0,19828968 ! telencephalon development GO:0021537 52 29 0,000 0,1757019 0,19819244 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1757019 0,19809528 ! eye morphogenesis GO:0048592 51 29 0,000 0,1757019 0,19799822 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1757019 0,19790126 ! organic anion transport GO:0015711 51 30 0,000 0,18118054 0,20397221 ! cholesterol transport GO:0030301 46 30 0,000 0,18118054 0,20387242 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,18118054 0,20377273 ! spliceosome assembly GO:0000245 49 30 0,000 0,18118054 0,20367313 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,18118054 0,20357364 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,18118054 0,20347423 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,18118054 0,20337493 ! ceramide metabolic process GO:0006672 43 30 0,000 0,18118054 0,20327572 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,18118054 0,20317661 ! adult locomotory behavior GO:0008344 47 30 0,000 0,18118054 0,2030776 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,18118054 0,20297868 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,18118054 0,20287986 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,18662307 0,20887253 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,18662307 0,20877094 ! odontogenesis GO:0042476 50 31 0,000 0,18662307 0,20866945 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,18662307 0,20856805 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,18662307 0,20846676 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,18662307 0,20836556 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,18662307 0,20826446 ! cell fate specification GO:0001708 37 31 0,000 0,18662307 0,20816346 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,18662307 0,20806256 ! RNA modification GO:0009451 40 31 0,000 0,18662307 0,20796175 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,19202973 0,21388299 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,19202973 0,21377947 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,19202973 0,21367604 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,19202973 0,21357272 ! cytokine production GO:0001816 44 32 0,000 0,19202973 0,21346949 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,19202973 0,21336637 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,19202973 0,21326334 ! vesicle localization GO:0051648 47 32 0,000 0,19202973 0,21316042 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,19740077 0,21901677 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,19740077 0,21891117 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,19740077 0,21880567 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,19740077 0,21870027 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,19740077 0,21859498 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,19740077 0,21848978 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,19740077 0,21838469 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,19740077 0,21827969 GO:0042593|glucose homeostasis, ! lipid homeostasis GO:0055088 55 33 0,000 0,19740077 0,2181748 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,19740077 0,21807001 ! regulation of proteolysis GO:0030162 50 33 0,000 0,19740077 0,21796532 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,19740077 0,21786073 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,19740077 0,21775624 ! mRNA catabolic process GO:0006402 48 34 0,000 0,2027364 0,22353486 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,2027364 0,22342776 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,2027364 0,22332075 ! feeding behavior GO:0007631 45 34 0,000 0,2027364 0,22321385 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,2027364 0,22310705 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,2027364 0,22300035 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,2027364 0,22289375 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,2027364 0,22278726 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,2027364 0,22268086 ! polyol metabolic process GO:0019751 44 34 0,000 0,2027364 0,22257457 ! aerobic respiration GO:0009060 47 34 0,000 0,2027364 0,22246838 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,2027364 0,22236229 ! embryonic organ development GO:0048568 45 34 0,000 0,2027364 0,2222563 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,2027364 0,22215042 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,20803687 0,22784991 ! Notch signaling pathway GO:0007219 56 35 0,000 0,20803687 0,22774146 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,20803687 0,22763311 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,20803687 0,22752487 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,20803687 0,22741673 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,20803687 0,2273087 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,20803687 0,22720076 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,20803687 0,22709293 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,20803687 0,2269852 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,2133024 0,23261997 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,2133024 0,23250973 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,2133024 0,23239959 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,2133024 0,23228955 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,21853322 0,23787336 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,21853322 0,23776084 ! learning GO:0007612 67 37 0,000 0,21853322 0,23764842 ! ion transmembrane transport GO:0034220 56 37 0,000 0,21853322 0,23753611 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,21853322 0,23742391 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,21853322 0,23731181 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,22372956 0,24284002 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,22372956 0,24272547 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,22372956 0,24261103 ! phagocytosis GO:0006909 60 38 0,000 0,22372956 0,2424967 ! maintenance of location in cell GO:0051651 69 38 0,000 0,22372956 0,24238248 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,22889165 0,24785819 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,22889165 0,24774155 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,22889165 0,24762502 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,22889165 0,2475086 ! chromatin remodeling GO:0006338 68 39 0,000 0,22889165 0,24739229 ! JNK cascade GO:0007254 54 39 0,000 0,22889165 0,24727609 ! cell growth GO:0016049 61 39 0,000 0,22889165 0,24715999 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,2340197 0,25257874 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,2340197 0,25246027 ! regulation of tube size GO:0035150 60 40 0,000 0,2340197 0,25234191 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,2340197 0,25222367 ! peptide metabolic process GO:0006518 56 40 0,000 0,2340197 0,25210553 ! inner ear development GO:0048839 57 40 0,000 0,2340197 0,2519875 ! double-strand break repair GO:0006302 67 40 0,000 0,2340197 0,25186958 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,2340197 0,25175178 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,2340197 0,25163408 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,2340197 0,2515165 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,23911394 0,25687158 ! glucose transport GO:0015758 52 41 0,000 0,23911394 0,25675166 ! endosome transport GO:0016197 71 41 0,000 0,23911394 0,25663185 ! striated muscle contraction GO:0006941 62 41 0,000 0,23911394 0,25651215 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,23911394 0,25639256 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,23911394 0,25627309 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,24417458 0,26157501 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,24417458 0,26145323 ! hexose transport GO:0008645 54 42 0,000 0,24417458 0,26133157 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,24417458 0,26121002 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,24417458 0,26108858 ! excretion GO:0007588 63 42 0,000 0,24417458 0,26096726 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,24417458 0,26084605 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,24417458 0,26072495 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,24920186 0,26596951 ! neuromuscular process GO:0050905 79 43 0,000 0,24920186 0,26584614 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,24920186 0,2657229 ! tRNA processing GO:0008033 49 43 0,000 0,24920186 0,26559976 ! response to insulin stimulus GO:0032868 63 43 0,000 0,24920186 0,26547674 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,25419599 0,27067166 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,25419599 0,2705464 ! glycolysis GO:0006096 53 44 0,000 0,25419599 0,27042127 ! regulation of ion transport GO:0043269 57 44 0,000 0,25419599 0,27029625 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,25419599 0,27017134 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,25419599 0,27004655 ! RNA catabolic process GO:0006401 64 45 0,000 0,25915718 0,27518999 ! regulation of translational initiation GO:0006446 64 45 0,000 0,25915718 0,275063 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,25915718 0,27493613 ! cell recognition GO:0008037 58 45 0,000 0,25915718 0,27480937 ! cell maturation GO:0048469 60 45 0,000 0,25915718 0,27468273 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,26408566 0,27977752 ! cell redox homeostasis GO:0045454 63 46 0,000 0,26408566 0,27964871 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,26408566 0,27952002 ! viral infectious cycle GO:0019058 71 47 0,000 0,26898162 0,28457117 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,26898162 0,28444033 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,26898162 0,28430962 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,26898162 0,28417902 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,26898162 0,28404854 ! chloride transport GO:0006821 67 48 0,000 0,27384529 0,28905194 ! gastrulation GO:0007369 73 48 0,000 0,27384529 0,28891935 ! heart morphogenesis GO:0003007 65 48 0,000 0,27384529 0,28878688 ! regulation of DNA replication GO:0006275 75 48 0,000 0,27384529 0,28865453 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,27384529 0,2885223 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,27384529 0,28839019 ! regulation of endocytosis GO:0030100 63 48 0,000 0,27384529 0,2882582 ! nuclear export GO:0051168 69 48 0,000 0,27384529 0,28812634 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,27867688 0,29307583 ! sensory perception of smell GO:0007608 61 49 0,000 0,27867688 0,29294188 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,27867688 0,29280806 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,27867688 0,29267435 ! RNA elongation GO:0006354 62 49 0,000 0,27867688 0,29254077 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,27867688 0,29240731 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,27867688 0,29227398 ! maintenance of location GO:0051235 84 49 0,000 0,27867688 0,29214076 ! membrane fusion GO:0006944 80 50 0,000 0,2834766 0,29703699 ! lipid modification GO:0030258 73 50 0,000 0,2834766 0,29690172 ! proton transport GO:0015992 75 50 0,000 0,2834766 0,29676658 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,2834766 0,29663157 ! hydrogen transport GO:0006818 77 51 0,000 0,28824466 0,30148372 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,28824466 0,30134669 ! adult behavior GO:0030534 80 51 0,000 0,28824466 0,30120977 ! transition metal ion transport GO:0000041 74 52 0,000 0,29298125 0,30602038 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,29298125 0,30588147 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,29298125 0,30574269 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,2976866 0,3105121 ! single fertilization GO:0007338 59 53 0,000 0,2976866 0,31037134 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,3023609 0,31510198 ! glucose catabolic process GO:0006007 66 54 0,000 0,3023609 0,31495927 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,3023609 0,31481669 ! exocytosis GO:0006887 74 55 0,000 0,30700435 0,31950679 ! mesoderm development GO:0007498 76 55 0,000 0,30700435 0,31936228 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,30700435 0,31921791 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,30700435 0,31907366 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,31161717 0,32372154 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,31161717 0,32357539 ! carbohydrate transport GO:0008643 74 57 0,000 0,31619954 0,32818544 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,31619954 0,32803741 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,31619954 0,32788951 ! developmental maturation GO:0021700 75 57 0,000 0,31619954 0,32774175 ! viral reproductive process GO:0022415 87 58 0,000 0,32075167 0,33231029 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,32075167 0,33216066 ! activation of MAPK activity GO:0000187 84 59 0,000 0,32527375 0,336692 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,32527375 0,33654054 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,32527375 0,33638922 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,32976599 0,3408817 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,32976599 0,34072856 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,32976599 0,34057556 ! fertilization GO:0009566 68 60 0,000 0,32976599 0,3404227 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,33422857 0,3448747 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,33422857 0,34472005 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,33422857 0,34456554 ! extracellular matrix organization GO:0030198 103 61 0,000 0,33422857 0,34441116 ! amine catabolic process GO:0009310 90 62 0,000 0,3386617 0,34882307 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,3386617 0,34866692 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,34306556 0,35304286 ! viral reproduction GO:0016032 92 63 0,000 0,34306556 0,35288497 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,34744034 0,35722521 ! hexose catabolic process GO:0019320 82 64 0,000 0,34744034 0,35706559 ! activation of immune response GO:0002253 83 65 0,000 0,35178625 0,36137042 ! antigen processing and presentation GO:0019882 96 66 0,000 0,35610345 0,36564194 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,35610345 0,36547878 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,36039215 0,36971541 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,36465253 0,37391923 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,36465253 0,3737526 ! inorganic anion transport GO:0015698 93 68 0,000 0,36465253 0,37358611 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,36888478 0,37775378 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,36888478 0,37758566 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,37308907 0,38171925 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,37308907 0,38154952 ! regulation of catabolic process GO:0009894 106 70 0,000 0,37308907 0,38137994 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,3772656 0,38547795 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,38141454 0,38954415 ! regulation of blood pressure GO:0008217 107 73 0,000 0,38553607 0,39357877 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,38963038 0,39758202 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,38963038 0,39740571 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,39369764 0,40137614 ! amine biosynthetic process GO:0009309 97 76 0,000 0,39773803 0,40531567 ! response to unfolded protein GO:0006986 99 76 0,000 0,39773803 0,40513617 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,40175173 0,40904337 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,40175173 0,40886238 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,40175173 0,40868154 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,40175173 0,40850087 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,4057389 0,41237272 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,4057389 0,41219058 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,40969973 0,41603063 ! regulation of lyase activity GO:0051339 133 79 0,000 0,40969973 0,41584704 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,40969973 0,4156636 ! chromatin assembly GO:0031497 102 80 0,000 0,41363439 0,4194705 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,41363439 0,41928563 ! forebrain development GO:0030900 131 80 0,000 0,41363439 0,41910092 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,41754304 0,42287495 ! regulation of neurological system process GO:0031644 122 81 0,000 0,41754304 0,42268882 ! vitamin metabolic process GO:0006766 103 81 0,000 0,41754304 0,42250286 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,42528303 0,43014554 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,42528303 0,42995647 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,4291147 0,43363963 ! sterol metabolic process GO:0016125 120 84 0,000 0,4291147 0,43344919 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,43670221 0,44091971 ! nucleosome organization GO:0034728 114 87 0,000 0,4404584 0,44451703 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,4404584 0,44432207 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,44418974 0,4478897 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,44418974 0,44769343 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,44789642 0,45123161 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,44789642 0,45103405 ! ATP metabolic process GO:0046034 137 91 0,000 0,45523642 0,45822484 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,45887006 0,46168029 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,45887006 0,46147841 ! positive regulation of immune response GO:0050778 121 92 0,000 0,45887006 0,46127672 ! DNA recombination GO:0006310 146 92 0,000 0,45887006 0,4610752 ! sulfur metabolic process GO:0006790 118 92 0,000 0,45887006 0,46087386 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,46247966 0,46429648 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,47316588 0,47481742 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,47668094 0,47813613 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,47668094 0,47792771 ! calcium ion transport GO:0006816 167 99 0,000 0,48364145 0,48469513 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,4870872 0,48793579 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,4870872 0,48772336 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,4870872 0,48751113 ! divalent metal ion transport GO:0070838 171 100 0,000 0,4870872 0,48729907 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,4870872 0,4870872