pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6744-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of epithelial cell proliferation GO:0050679 14 14 3,000 1,668E-06 3,073E-03 ! positive regulation of cell migration GO:0030335 36 36 4,000 3,452E-06 3,181E-03 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 3,000 3,907E-06 2,4E-03 ! pigmentation GO:0043473 17 17 3,000 3,907E-06 1,8E-03 ! positive regulation of cell motion GO:0051272 39 39 4,000 5,194E-06 1,915E-03 ! peptidyl-serine phosphorylation GO:0018105 6 6 2,000 5,518E-06 1,695E-03 ! regulation of cell migration GO:0030334 71 71 5,000 6,593E-06 1,736E-03 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 3,000 9,635E-06 2,22E-03 ! regulation of locomotion GO:0040012 79 79 5,000 1,229E-05 2,518E-03 ! regulation of cell motion GO:0051270 79 79 5,000 1,229E-05 2,266E-03 ! negative regulation of bone remodeling GO:0046851 8 8 2,000 1,53E-05 2,564E-03 ! peptidyl-serine modification GO:0018209 8 8 2,000 1,53E-05 2,351E-03 ! positive regulation of leukocyte migration GO:0002687 8 8 2,000 1,53E-05 2,17E-03 ! negative regulation of tissue remodeling GO:0034104 9 9 2,000 2,285E-05 3,008E-03 ! regulation of leukocyte migration GO:0002685 9 9 2,000 2,285E-05 2,807E-03 ! collagen catabolic process GO:0030574 9 9 2,000 2,285E-05 2,632E-03 ! defense response to virus GO:0051607 9 9 2,000 2,285E-05 2,477E-03 ! gland morphogenesis GO:0022612 10 10 2,000 3,249E-05 3,327E-03 ! negative regulation of homeostatic process GO:0032845 10 10 2,000 3,249E-05 3,152E-03 ! regulation of epithelial cell proliferation GO:0050678 29 29 3,000 3,677E-05 3,388E-03 ! peptidyl-amino acid modification GO:0018193 61 59 4,000 4,089E-05 3,588E-03 ! hindbrain development GO:0030902 11 11 2,000 4,446E-05 3,725E-03 ! proximal/distal pattern formation GO:0009954 11 11 2,000 4,446E-05 3,563E-03 ! collagen metabolic process GO:0032963 12 12 2,000 5,901E-05 4,531E-03 ! regulation of bone remodeling GO:0046850 34 34 3,000 7,006E-05 5,165E-03 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 2,000 7,635E-05 5,412E-03 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 2,000 7,635E-05 5,212E-03 ! response to corticosteroid stimulus GO:0031960 13 13 2,000 7,635E-05 5,026E-03 GO:0051384|response to glucocorticoid stimulus, ! multicellular organismal catabolic process GO:0044243 13 13 2,000 7,635E-05 4,852E-03 ! positive regulation of locomotion GO:0040017 13 13 2,000 7,635E-05 4,691E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! regulation of tissue remodeling GO:0034103 35 35 3,000 7,871E-05 4,68E-03 ! response to steroid hormone stimulus GO:0048545 35 35 3,000 7,871E-05 4,533E-03 ! regionalization GO:0003002 70 69 4,000 8,733E-05 4,877E-03 ! regulation of behavior GO:0050795 14 14 2,000 9,672E-05 5,243E-03 ! leukocyte homeostasis GO:0001776 15 15 2,000 1,203E-04 6,336E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 2,000 2,128E-04 0,01089385 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 4,000 2,487E-04 0,01238706 ! multicellular organismal metabolic process GO:0044236 19 19 2,000 2,515E-04 0,01219829 ! gland development GO:0048732 51 49 3,000 2,975E-04 0,01405761 ! positive regulation of MAP kinase activity GO:0043406 50 49 3,000 2,975E-04 0,01370617 ! anterior/posterior pattern formation GO:0009952 51 50 3,000 3,218E-04 0,01446391 ! interphase of mitotic cell cycle GO:0051329 52 51 3,000 3,475E-04 0,01524664 GO:0051325|interphase, ! pattern specification process GO:0007389 96 94 4,000 3,767E-04 0,01614454 ! positive regulation of transcription factor activity GO:0051091 22 22 2,000 3,941E-04 0,0165091 GO:0090047|positive regulation of transcription regulator activity, ! response to hypoxia GO:0001666 53 53 3,000 4,032E-04 0,01651264 ! metencephalon development GO:0022037 5 5 1,000 4,318E-04 0,01730048 ! mRNA stabilization GO:0048255 5 5 1,000 4,318E-04 0,01693238 GO:0043489|RNA stabilization, ! endocrine pancreas development GO:0031018 5 5 1,000 4,318E-04 0,01657962 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 1,000 4,318E-04 0,01624126 GO:0033135|regulation of peptidyl-serine phosphorylation, ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 4,318E-04 0,01591644 ! fear response GO:0042596 5 5 1,000 4,318E-04 0,01560435 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 1,000 4,318E-04 0,01530427 ! response to UV-B GO:0010224 5 5 1,000 4,318E-04 0,01501551 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 4,318E-04 0,01473744 ! positive regulation of interleukin-6 production GO:0032755 5 5 1,000 4,318E-04 0,01446949 ! cellular pigmentation GO:0033059 5 5 1,000 4,318E-04 0,01421111 ! DNA methylation GO:0006306 5 5 1,000 4,318E-04 0,01396179 GO:0006305|DNA alkylation, ! T cell lineage commitment GO:0002360 5 5 1,000 4,318E-04 0,01372107 ! peptidyl-lysine modification GO:0018205 5 5 1,000 4,318E-04 0,01348851 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 1,000 4,318E-04 0,0132637 GO:0002688|regulation of leukocyte chemotaxis, ! sarcomere organization GO:0045214 5 5 1,000 4,318E-04 0,01304626 ! positive regulation of T-helper cell differentiation GO:0045624 5 5 1,000 4,318E-04 0,01283584 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 1,000 4,318E-04 0,01263209 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 4,318E-04 0,01243472 ! spleen development GO:0048536 5 5 1,000 4,318E-04 0,01224341 ! myeloid cell homeostasis GO:0002262 5 5 1,000 4,318E-04 0,01205791 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 4,318E-04 0,01187794 ! response to nicotine GO:0035094 5 5 1,000 4,318E-04 0,01170326 ! response to oxygen levels GO:0070482 55 54 3,000 4,333E-04 0,01157406 ! negative regulation of multicellular organismal process GO:0051241 55 54 3,000 4,333E-04 0,01140872 ! response to estrogen stimulus GO:0043627 23 23 2,000 4,511E-04 0,01171068 ! posttranscriptional regulation of gene expression GO:0010608 98 98 4,000 4,569E-04 0,01169409 ! T cell differentiation GO:0030217 24 24 2,000 5,132E-04 0,01295616 ! regulation of binding GO:0051098 60 57 3,000 5,334E-04 0,01328394 ! regulation of protein localization GO:0032880 58 57 3,000 5,334E-04 0,01310682 ! regulation of T cell proliferation GO:0042129 25 25 2,000 5,804E-04 0,01407571 ! positive regulation of DNA binding GO:0043388 26 25 2,000 5,804E-04 0,01389291 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 6,45E-04 0,01523908 GO:0018409|peptide or protein amino-terminal blocking, ! regulation of positive chemotaxis GO:0050926 6 6 1,000 6,45E-04 0,01504618 GO:0050927|positive regulation of positive chemotaxis, ! regulation of chemokine biosynthetic process GO:0045073 6 6 1,000 6,45E-04 0,0148581 ! oligodendrocyte differentiation GO:0048709 6 6 1,000 6,45E-04 0,01467467 ! ER overload response GO:0006983 6 6 1,000 6,45E-04 0,01449571 ! focal adhesion formation GO:0048041 7 6 1,000 6,45E-04 0,01432106 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 6,45E-04 0,01415058 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 6,45E-04 0,0139841 ! negative regulation of ossification GO:0030279 6 6 1,000 6,45E-04 0,01382149 ! regulation of bone resorption GO:0045124 6 6 1,000 6,45E-04 0,01366262 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 6,45E-04 0,01350737 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 6,45E-04 0,0133556 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 1,000 6,45E-04 0,0132072 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! regulation of T-helper 2 type immune response GO:0002828 6 6 1,000 6,45E-04 0,01306207 ! salivary gland morphogenesis GO:0007435 6 6 1,000 6,45E-04 0,01292009 ! thymus development GO:0048538 6 6 1,000 6,45E-04 0,01278116 ! localization within membrane GO:0051668 6 6 1,000 6,45E-04 0,0126452 ! positive regulation of binding GO:0051099 27 26 2,000 6,531E-04 0,01266991 ! negative regulation of cell migration GO:0030336 26 26 2,000 6,531E-04 0,01253793 ! regulation of T cell differentiation GO:0045580 26 26 2,000 6,531E-04 0,01240867 ! protein amino acid autophosphorylation GO:0046777 28 28 2,000 8,152E-04 0,01533127 ! regulation of mast cell proliferation GO:0070666 28 28 2,000 8,152E-04 0,01517641 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 1,000 8,991E-04 0,01657023 ! regulation of chemokine production GO:0032642 7 7 1,000 8,991E-04 0,01640617 ! hair follicle morphogenesis GO:0031069 7 7 1,000 8,991E-04 0,01624532 ! digestive system development GO:0055123 7 7 1,000 8,991E-04 0,0160876 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 8,991E-04 0,01593291 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 8,991E-04 0,01578117 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! myofibril assembly GO:0030239 7 7 1,000 8,991E-04 0,01563229 GO:0055002|striated muscle cell development, ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 8,991E-04 0,01548619 ! response to estradiol stimulus GO:0032355 7 7 1,000 8,991E-04 0,0153428 ! platelet activation GO:0030168 8 7 1,000 8,991E-04 0,01520204 ! response to gamma radiation GO:0010332 8 7 1,000 8,991E-04 0,01506384 ! positive regulation of acute inflammatory response GO:0002675 7 7 1,000 8,991E-04 0,01492813 ! regulation of mRNA stability GO:0043488 7 7 1,000 8,991E-04 0,01479485 ! negative regulation of T cell activation GO:0050868 7 7 1,000 8,991E-04 0,01466392 ! positive regulation of cell cycle GO:0045787 29 29 2,000 9,051E-04 0,01463164 ! regulation of lymphocyte proliferation GO:0050670 29 29 2,000 9,051E-04 0,01450441 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! positive regulation of protein transport GO:0051222 29 29 2,000 9,051E-04 0,01437937 ! response to UV GO:0009411 29 29 2,000 9,051E-04 0,01425647 ! regulation of MAP kinase activity GO:0043405 67 66 3,000 9,314E-04 0,01454755 ! striated muscle tissue development GO:0014706 69 67 3,000 9,857E-04 0,01526666 ! response to reactive oxygen species GO:0000302 31 30 2,000 1,001E-03 0,01537247 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 1,001E-03 0,01524542 ! regulation of ossification GO:0030278 30 30 2,000 1,001E-03 0,01512046 ! response to radiation GO:0009314 70 68 3,000 1,042E-03 0,01561708 ! digestion GO:0007586 31 31 2,000 1,103E-03 0,01639369 ! negative regulation of cell motion GO:0051271 31 31 2,000 1,103E-03 0,01626254 ! wound healing GO:0042060 74 70 3,000 1,162E-03 0,0169979 ! muscle tissue development GO:0060537 72 70 3,000 1,162E-03 0,01686406 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 1,194E-03 0,0171872 ! positive regulation of translation GO:0045727 8 8 1,000 1,194E-03 0,01705396 ! embryonic forelimb morphogenesis GO:0035115 8 8 1,000 1,194E-03 0,01692278 ! pancreas development GO:0031016 8 8 1,000 1,194E-03 0,0167936 ! T cell selection GO:0045058 8 8 1,000 1,194E-03 0,01666637 ! Golgi organization GO:0007030 8 8 1,000 1,194E-03 0,01654106 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 1,194E-03 0,01641762 ! sex determination GO:0007530 8 8 1,000 1,194E-03 0,01629601 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 1,194E-03 0,01617619 ! alpha-beta T cell activation GO:0046631 8 8 1,000 1,194E-03 0,01605811 ! muscle cell development GO:0055001 8 8 1,000 1,194E-03 0,01594175 ! salivary gland development GO:0007431 8 8 1,000 1,194E-03 0,01582706 ! T cell homeostasis GO:0043029 8 8 1,000 1,194E-03 0,01571401 ! regulation of acute inflammatory response GO:0002673 8 8 1,000 1,194E-03 0,01560256 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 1,000 1,194E-03 0,01549269 ! regulation of immunoglobulin production GO:0002637 8 8 1,000 1,194E-03 0,01538434 ! regulation of RNA stability GO:0043487 8 8 1,000 1,194E-03 0,01527751 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 1,194E-03 0,01517215 ! peptide hormone secretion GO:0030072 8 8 1,000 1,194E-03 0,01506823 ! actin filament polymerization GO:0030041 9 8 1,000 1,194E-03 0,01496572 ! negative regulation of cell growth GO:0030308 32 32 2,000 1,211E-03 0,01508547 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 2,000 1,211E-03 0,01498423 ! regulation of lymphocyte differentiation GO:0045619 32 32 2,000 1,211E-03 0,01488433 ! negative regulation of cell size GO:0045792 33 33 2,000 1,326E-03 0,01618852 ! regulation of angiogenesis GO:0045765 35 34 2,000 1,448E-03 0,01755613 ! response to metal ion GO:0010038 34 34 2,000 1,448E-03 0,01744138 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 1,528E-03 0,01828889 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 1,528E-03 0,0181709 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 1,000 1,528E-03 0,01805442 ! response to alkaloid GO:0043279 10 9 1,000 1,528E-03 0,01793942 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 1,000 1,528E-03 0,01782588 ! response to ethanol GO:0045471 9 9 1,000 1,528E-03 0,01771377 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 1,000 1,528E-03 0,01760306 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 1,528E-03 0,01749372 ! pigmentation during development GO:0048066 9 9 1,000 1,528E-03 0,01738574 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 1,528E-03 0,01727908 GO:0060675|ureteric bud morphogenesis, ! peptide secretion GO:0002790 9 9 1,000 1,528E-03 0,01717372 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 1,000 1,528E-03 0,01706963 ! T cell differentiation in the thymus GO:0033077 9 9 1,000 1,528E-03 0,0169668 ! histone acetylation GO:0016573 9 9 1,000 1,528E-03 0,01686521 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 1,528E-03 0,01676482 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 2,000 1,576E-03 0,01718998 ! positive regulation of phosphorylation GO:0042327 35 35 2,000 1,576E-03 0,01708886 ! response to inorganic substance GO:0010035 36 36 2,000 1,712E-03 0,01844703 ! embryonic limb morphogenesis GO:0030326 36 36 2,000 1,712E-03 0,01833978 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of phosphorus metabolic process GO:0010562 36 36 2,000 1,712E-03 0,01823377 GO:0045937|positive regulation of phosphate metabolic process, ! coagulation GO:0050817 39 36 2,000 1,712E-03 0,01812898 GO:0007596|blood coagulation, ! regulation of transcription factor activity GO:0051090 38 37 2,000 1,854E-03 0,0195245 GO:0090046|regulation of transcription regulator activity, ! response to drug GO:0042493 37 37 2,000 1,854E-03 0,01941356 ! lung development GO:0030324 38 37 2,000 1,854E-03 0,01930388 ! negative regulation of growth GO:0045926 37 37 2,000 1,854E-03 0,01919543 ! positive regulation of anti-apoptosis GO:0045768 10 10 1,000 1,902E-03 0,01958459 GO:0045767|regulation of anti-apoptosis, ! hormone secretion GO:0046879 10 10 1,000 1,902E-03 0,01947579 ! forelimb morphogenesis GO:0035136 10 10 1,000 1,902E-03 0,01936819 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 1,902E-03 0,01926177 ! epidermis morphogenesis GO:0048730 10 10 1,000 1,902E-03 0,01915652 ! plasma membrane organization GO:0007009 10 10 1,000 1,902E-03 0,0190524 ! cell-substrate junction assembly GO:0007044 11 10 1,000 1,902E-03 0,01894942 ! exocrine system development GO:0035272 10 10 1,000 1,902E-03 0,01884754 ! neuromuscular junction development GO:0007528 10 10 1,000 1,902E-03 0,01874675 ! regulation of protein binding GO:0043393 11 10 1,000 1,902E-03 0,01864703 ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 1,000 1,902E-03 0,01854837 ! lymphocyte homeostasis GO:0002260 10 10 1,000 1,902E-03 0,01845075 ! gut development GO:0048565 10 10 1,000 1,902E-03 0,01835415 ! neuron projection development GO:0031175 85 80 3,000 1,909E-03 0,01832756 ! tube development GO:0035295 83 81 3,000 1,999E-03 0,0190867 ! regulation of homeostatic process GO:0032844 38 38 2,000 2,003E-03 0,01903288 ! hemostasis GO:0007599 42 39 2,000 2,16E-03 0,02041772 ! respiratory tube development GO:0030323 40 39 2,000 2,16E-03 0,02031354 ! cytokine-mediated signaling pathway GO:0019221 39 39 2,000 2,16E-03 0,02021043 ! respiratory system development GO:0060541 40 39 2,000 2,16E-03 0,02010836 ! lymphocyte differentiation GO:0030098 39 39 2,000 2,16E-03 0,02000731 ! limb development GO:0060173 39 39 2,000 2,16E-03 0,01990727 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 1,000 2,315E-03 0,02122619 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 1,000 2,315E-03 0,02112111 ! protein amino acid acetylation GO:0006473 11 11 1,000 2,315E-03 0,02101706 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 1,000 2,315E-03 0,02091404 GO:0032388|positive regulation of intracellular transport, ! regulation of viral genome replication GO:0045069 11 11 1,000 2,315E-03 0,02081202 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 1,000 2,315E-03 0,02071099 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 1,000 2,315E-03 0,02061093 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 2,315E-03 0,02051184 ! oogenesis GO:0048477 11 11 1,000 2,315E-03 0,0204137 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 2,315E-03 0,02031649 ! positive regulation of protein kinase activity GO:0045860 89 86 3,000 2,49E-03 0,02174842 ! negative regulation of ligase activity GO:0051352 43 42 2,000 2,676E-03 0,02326332 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 2,000 2,676E-03 0,02315411 ! positive regulation of transferase activity GO:0051347 91 88 3,000 2,708E-03 0,02331955 GO:0033674|positive regulation of kinase activity, ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 1,000 2,766E-03 0,02371165 ! C21-steroid hormone metabolic process GO:0008207 13 12 1,000 2,766E-03 0,02360188 ! actomyosin structure organization GO:0031032 12 12 1,000 2,766E-03 0,02349311 ! acute-phase response GO:0006953 12 12 1,000 2,766E-03 0,02338535 ! male gonad development GO:0008584 12 12 1,000 2,766E-03 0,02327856 ! regulation of alpha-beta T cell activation GO:0046634 12 12 1,000 2,766E-03 0,02317275 ! renal system process GO:0003014 12 12 1,000 2,766E-03 0,0230679 ! regulation of interleukin-6 production GO:0032675 12 12 1,000 2,766E-03 0,02296399 ! regulation of chromosome organization GO:0033044 12 12 1,000 2,766E-03 0,02286101 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 2,766E-03 0,02275895 ! somitogenesis GO:0001756 13 12 1,000 2,766E-03 0,0226578 ! hormone transport GO:0009914 12 12 1,000 2,766E-03 0,02255755 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 2,766E-03 0,02245817 ! negative regulation of translation GO:0017148 12 12 1,000 2,766E-03 0,02235967 ! homeostasis of number of cells GO:0048872 44 43 2,000 2,863E-03 0,02304389 ! humoral immune response GO:0006959 44 44 2,000 3,059E-03 0,02450799 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 2,000 3,059E-03 0,0244019 ! negative regulation of hormone secretion GO:0046888 13 13 1,000 3,255E-03 0,02585919 ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 1,000 3,255E-03 0,0257482 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 1,000 3,255E-03 0,02563817 ! regeneration GO:0031099 13 13 1,000 3,255E-03 0,02552907 ! post-embryonic development GO:0009791 14 13 1,000 3,255E-03 0,02542089 ! vasculogenesis GO:0001570 13 13 1,000 3,255E-03 0,02531363 ! mitochondrial membrane organization GO:0007006 13 13 1,000 3,255E-03 0,02520727 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 1,000 3,255E-03 0,0251018 ! ureteric bud development GO:0001657 13 13 1,000 3,255E-03 0,02499721 ! cell aging GO:0007569 13 13 1,000 3,255E-03 0,02489349 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 3,255E-03 0,02479062 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 3,255E-03 0,02468861 ! regulation of viral reproduction GO:0050792 13 13 1,000 3,255E-03 0,02458742 ! negative regulation of phosphorylation GO:0042326 13 13 1,000 3,255E-03 0,02448707 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 3,255E-03 0,02438752 ! regulation of cell-substrate adhesion GO:0010810 14 13 1,000 3,255E-03 0,02428879 GO:0001952|regulation of cell-matrix adhesion, ! response to cytokine stimulus GO:0034097 13 13 1,000 3,255E-03 0,02419085 ! tissue homeostasis GO:0001894 13 13 1,000 3,255E-03 0,0240937 GO:0048871|multicellular organismal homeostasis, ! regulation of DNA binding GO:0051101 47 45 2,000 3,262E-03 0,02404555 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 2,000 3,262E-03 0,02394975 ! Wnt receptor signaling pathway GO:0016055 46 45 2,000 3,262E-03 0,02385472 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 2,000 3,473E-03 0,02529997 ! positive regulation of ligase activity GO:0051351 47 46 2,000 3,473E-03 0,02520037 ! regulation of membrane potential GO:0042391 46 46 2,000 3,473E-03 0,02510154 ! regulation of cell growth GO:0001558 97 96 3,000 3,71E-03 0,02671202 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 1,000 3,782E-03 0,02711872 ! protein amino acid acylation GO:0043543 14 14 1,000 3,782E-03 0,02701361 ! hair cycle GO:0042633 14 14 1,000 3,782E-03 0,02690931 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! multicellular organismal response to stress GO:0033555 14 14 1,000 3,782E-03 0,02680581 ! actin polymerization or depolymerization GO:0008154 15 14 1,000 3,782E-03 0,02670311 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 1,000 3,782E-03 0,02660118 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 1,000 3,782E-03 0,02650004 ! response to organic cyclic substance GO:0014070 15 14 1,000 3,782E-03 0,02639966 ! DNA modification GO:0006304 14 14 1,000 3,782E-03 0,02630004 ! positive regulation of inflammatory response GO:0050729 14 14 1,000 3,782E-03 0,02620117 ! positive regulation of osteoblast differentiation GO:0045669 14 14 1,000 3,782E-03 0,02610304 ! response to molecule of bacterial origin GO:0002237 14 14 1,000 3,782E-03 0,02600564 ! actin filament organization GO:0007015 50 48 2,000 3,921E-03 0,02686065 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 2,000 3,921E-03 0,02676116 ! leukocyte differentiation GO:0002521 50 49 2,000 4,157E-03 0,02826933 ! ossification GO:0001503 50 49 2,000 4,157E-03 0,0281654 GO:0060348|bone development, ! skeletal muscle tissue development GO:0007519 50 49 2,000 4,157E-03 0,02806223 GO:0060538|skeletal muscle organ development, ! regulation of ligase activity GO:0051340 50 49 2,000 4,157E-03 0,02795981 ! response to hormone stimulus GO:0009725 102 100 3,000 4,296E-03 0,02878793 ! muscle organ development GO:0007517 102 100 3,000 4,296E-03 0,02868363 ! hemopoiesis GO:0030097 104 100 3,000 4,296E-03 0,02858008 ! striated muscle cell differentiation GO:0051146 16 15 1,000 4,345E-03 0,0288044 ! ovarian follicle development GO:0001541 15 15 1,000 4,345E-03 0,02870116 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 4,345E-03 0,02859866 ! response to ionizing radiation GO:0010212 16 15 1,000 4,345E-03 0,02849688 ! regulation of production of molecular mediator of immune response GO:0002700 15 15 1,000 4,345E-03 0,02839583 ! positive regulation of B cell activation GO:0050871 15 15 1,000 4,345E-03 0,02829549 ! negative regulation of cell activation GO:0050866 15 15 1,000 4,345E-03 0,02819586 ! T cell activation GO:0042110 51 50 2,000 4,402E-03 0,02846363 ! regulation of body fluid levels GO:0050878 55 52 2,000 4,917E-03 0,03168569 ! response to light stimulus GO:0009416 53 52 2,000 4,917E-03 0,03157528 ! segmentation GO:0035282 17 16 1,000 4,945E-03 0,03164152 ! lymphocyte proliferation GO:0046651 16 16 1,000 4,945E-03 0,03153204 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 1,000 4,945E-03 0,03142331 ! positive regulation of mitosis GO:0045840 16 16 1,000 4,945E-03 0,03131532 GO:0051785|positive regulation of nuclear division, ! cellular response to reactive oxygen species GO:0034614 16 16 1,000 4,945E-03 0,03120808 ! triglyceride metabolic process GO:0006641 16 16 1,000 4,945E-03 0,03110157 ! positive regulation of cell development GO:0010720 16 16 1,000 4,945E-03 0,03099578 ! positive regulation of MAPKKK cascade GO:0043410 17 16 1,000 4,945E-03 0,03089071 ! regulation of T cell activation GO:0050863 53 53 2,000 5,188E-03 0,03230152 ! regulation of protein transport GO:0051223 53 53 2,000 5,188E-03 0,03219276 GO:0070201|regulation of establishment of protein localization, ! response to virus GO:0009615 54 54 2,000 5,468E-03 0,03381442 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 1,000 5,58E-03 0,03439469 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 5,58E-03 0,03428004 ! myelination GO:0042552 17 17 1,000 5,58E-03 0,03416616 ! cell junction assembly GO:0034329 18 17 1,000 5,58E-03 0,03405302 ! tissue remodeling GO:0048771 17 17 1,000 5,58E-03 0,03394064 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 5,58E-03 0,03382899 ! response to toxin GO:0009636 18 17 1,000 5,58E-03 0,03371808 ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 5,58E-03 0,03360789 ! positive regulation of protein secretion GO:0050714 17 17 1,000 5,58E-03 0,03349841 ! regulation of osteoblast differentiation GO:0045667 17 17 1,000 5,58E-03 0,03338965 ! regulation of cell adhesion GO:0030155 56 55 2,000 5,756E-03 0,03433204 ! reproductive developmental process GO:0003006 56 56 2,000 6,054E-03 0,03599064 ! meiosis I GO:0007127 18 18 1,000 6,251E-03 0,03704338 ! mononuclear cell proliferation GO:0032943 18 18 1,000 6,251E-03 0,03692465 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 1,000 6,251E-03 0,03680668 ! neutral lipid metabolic process GO:0006638 18 18 1,000 6,251E-03 0,03668947 GO:0006639|acylglycerol metabolic process, ! B cell differentiation GO:0030183 18 18 1,000 6,251E-03 0,03657299 ! ensheathment of neurons GO:0007272 18 18 1,000 6,251E-03 0,03645725 GO:0008366|axon ensheathment, ! glial cell differentiation GO:0010001 19 19 1,000 6,957E-03 0,04044578 ! regulation of JAK-STAT cascade GO:0046425 19 19 1,000 6,957E-03 0,04031859 ! regulation of endothelial cell proliferation GO:0001936 19 19 1,000 6,957E-03 0,0401922 ! positive regulation of T cell proliferation GO:0042102 19 19 1,000 6,957E-03 0,0400666 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 6,957E-03 0,03994178 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 6,957E-03 0,03981774 ! metanephros development GO:0001656 19 19 1,000 6,957E-03 0,03969446 ! cellular response to oxidative stress GO:0034599 19 19 1,000 6,957E-03 0,03957195 ! positive regulation of T cell differentiation GO:0045582 19 19 1,000 6,957E-03 0,03945019 ! peripheral nervous system development GO:0007422 19 19 1,000 6,957E-03 0,03932917 ! regulation of protein stability GO:0031647 19 19 1,000 6,957E-03 0,0392089 ! hormone biosynthetic process GO:0042446 19 19 1,000 6,957E-03 0,03908936 ! dorsal/ventral pattern formation GO:0009953 19 19 1,000 6,957E-03 0,03897055 ! regulation of cell shape GO:0008360 21 19 1,000 6,957E-03 0,03885246 ! response to heat GO:0009408 19 19 1,000 6,957E-03 0,03873508 ! immune effector process GO:0002252 59 59 2,000 7,001E-03 0,03886594 ! protein polymerization GO:0051258 65 60 2,000 7,336E-03 0,04059964 ! proteasomal protein catabolic process GO:0010498 62 61 2,000 7,679E-03 0,04237454 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! regulation of protein amino acid phosphorylation GO:0001932 62 61 2,000 7,679E-03 0,04224805 ! regulation of muscle development GO:0048634 21 20 1,000 7,697E-03 0,04221902 ! organic ether metabolic process GO:0018904 20 20 1,000 7,697E-03 0,04209374 GO:0006662|glycerol ether metabolic process, ! neural tube development GO:0021915 21 20 1,000 7,697E-03 0,04196921 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 7,697E-03 0,0418454 ! female gamete generation GO:0007292 20 20 1,000 7,697E-03 0,04172233 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 7,697E-03 0,04159997 ! regulation of B cell activation GO:0050864 20 20 1,000 7,697E-03 0,04147834 ! axonogenesis GO:0007409 66 62 2,000 8,032E-03 0,04315993 ! regulation of lymphocyte activation GO:0051249 62 62 2,000 8,032E-03 0,04303447 ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 8,471E-03 0,04525352 ! mammary gland development GO:0030879 23 21 1,000 8,471E-03 0,04512273 ! regulation of action potential in neuron GO:0019228 21 21 1,000 8,471E-03 0,04499269 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 8,471E-03 0,04486341 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 1,000 8,471E-03 0,04473486 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 1,000 8,471E-03 0,04460704 ! regulation of response to external stimulus GO:0032101 65 64 2,000 8,767E-03 0,04603372 ! angiogenesis GO:0001525 65 64 2,000 8,767E-03 0,04590294 ! regulation of hormone levels GO:0010817 66 65 2,000 9,149E-03 0,0477656 ! sister chromatid segregation GO:0000819 22 22 1,000 9,279E-03 0,04830811 ! cell junction organization GO:0034330 23 22 1,000 9,279E-03 0,04817203 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 1,000 9,279E-03 0,04803672 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! ovulation cycle process GO:0022602 22 22 1,000 9,279E-03 0,04790216 ! spindle organization GO:0007051 22 22 1,000 9,279E-03 0,04776836 ! cell chemotaxis GO:0060326 23 22 1,000 9,279E-03 0,0476353 GO:0030595|leukocyte chemotaxis, ! male sex differentiation GO:0046661 22 22 1,000 9,279E-03 0,04750298 ! biopolymer methylation GO:0043414 22 22 1,000 9,279E-03 0,04737139 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 1,000 9,279E-03 0,04724053 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 1,000 9,279E-03 0,04711039 ! cytokinesis GO:0000910 23 22 1,000 9,279E-03 0,04698097 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 9,941E-03 0,05019575 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,01011967 0,05095781 ! regulation of hormone secretion GO:0046883 23 23 1,000 0,01011967 0,05081896 ! endocrine system development GO:0035270 23 23 1,000 0,01011967 0,05068087 ! positive regulation of growth GO:0045927 23 23 1,000 0,01011967 0,05054352 ! female gonad development GO:0008585 23 23 1,000 0,01011967 0,05040691 ! calcium-mediated signaling GO:0019722 23 23 1,000 0,01011967 0,05027105 ! cell projection assembly GO:0030031 25 23 1,000 0,01011967 0,05013591 ! regulation of cell size GO:0008361 68 68 2,000 0,01035182 0,05114851 ! regulation of translation GO:0006417 69 69 2,000 0,01077231 0,05308385 ! regulation of leukocyte activation GO:0002694 69 69 2,000 0,01077231 0,05294229 ! regulation of mitotic cell cycle GO:0007346 72 69 2,000 0,01077231 0,05280149 ! mitochondrial transport GO:0006839 24 24 1,000 0,01099299 0,05374027 ! regulation of action potential GO:0001508 24 24 1,000 0,01099299 0,0535981 ! gliogenesis GO:0042063 24 24 1,000 0,01099299 0,05345668 ! ovulation cycle GO:0042698 24 24 1,000 0,01099299 0,05331601 ! androgen receptor signaling pathway GO:0030521 24 24 1,000 0,01099299 0,05317607 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,01099299 0,05303686 ! glucan metabolic process GO:0044042 25 24 1,000 0,01099299 0,05289839 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! positive regulation of transport GO:0051050 71 70 2,000 0,01120261 0,05376671 ! cell part morphogenesis GO:0032990 75 70 2,000 0,01120261 0,05362706 ! regulation of cell activation GO:0050865 71 71 2,000 0,01164278 0,05558975 ! negative regulation of secretion GO:0051048 26 25 1,000 0,01189843 0,05666358 ! regulation of intracellular protein transport GO:0033157 25 25 1,000 0,01189843 0,05651754 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,01189843 0,05637225 GO:0046660|female sex differentiation, ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 1,000 0,01189843 0,05622771 ! negative regulation of immune system process GO:0002683 25 25 1,000 0,01189843 0,0560839 ! positive regulation of cytokine production GO:0001819 25 25 1,000 0,01189843 0,05594083 ! positive regulation of defense response GO:0031349 26 26 1,000 0,01283554 0,06019314 ! regulation of protein secretion GO:0050708 26 26 1,000 0,01283554 0,06004036 ! germ cell development GO:0007281 27 26 1,000 0,01283554 0,05988836 ! pigment metabolic process GO:0042440 26 26 1,000 0,01283554 0,05973713 ! synapse organization GO:0050808 26 26 1,000 0,01283554 0,05958666 ! response to oxidative stress GO:0006979 76 75 2,000 0,01350279 0,06252674 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 1,000 0,01380388 0,06376079 ! energy reserve metabolic process GO:0006112 28 27 1,000 0,01380388 0,06360138 ! learning or memory GO:0007611 28 27 1,000 0,01380388 0,06344278 ! mesenchymal cell development GO:0014031 29 27 1,000 0,01380388 0,06328496 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! defense response to bacterium GO:0042742 27 27 1,000 0,01380388 0,06312792 ! positive regulation of multicellular organismal process GO:0051240 76 76 2,000 0,0139928 0,06383348 ! cell morphogenesis involved in differentiation GO:0000904 82 77 2,000 0,01449287 0,0659515 ! tRNA aminoacylation for protein translation GO:0006418 28 28 1,000 0,01480301 0,06719691 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! histone modification GO:0016570 28 28 1,000 0,01480301 0,06703181 ! developmental growth GO:0048589 28 28 1,000 0,01480301 0,06686751 ! regulation of protein modification process GO:0031399 79 78 2,000 0,01500303 0,06760534 ! leukocyte migration GO:0050900 30 29 1,000 0,01583249 0,07116896 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,01583249 0,0709958 ! regulation of gene expression, epigenetic GO:0040029 29 29 1,000 0,01583249 0,07082348 ! covalent chromatin modification GO:0016569 29 29 1,000 0,01583249 0,07065199 ! lymphocyte activation GO:0046649 82 81 2,000 0,0165943 0,07387267 ! lipid catabolic process GO:0016042 82 81 2,000 0,0165943 0,07369467 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 1,000 0,01689188 0,07483592 ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,01689188 0,07465646 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 1,000 0,01689188 0,07447786 ! response to temperature stimulus GO:0009266 30 30 1,000 0,01689188 0,0743001 ! vascular process in circulatory system GO:0003018 31 30 1,000 0,01689188 0,0741232 ! regulation of inflammatory response GO:0050727 30 30 1,000 0,01689188 0,07394713 ! vesicle organization GO:0016050 30 30 1,000 0,01689188 0,0737719 ! establishment of organelle localization GO:0051656 31 30 1,000 0,01689188 0,0735975 ! blood vessel morphogenesis GO:0048514 84 83 2,000 0,017706 0,07696265 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,01798077 0,0779731 ! B cell activation GO:0042113 31 31 1,000 0,01798077 0,07779006 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,01798077 0,07760788 ! aging GO:0007568 32 31 1,000 0,01798077 0,07742656 ! regulation of intracellular transport GO:0032386 31 31 1,000 0,01798077 0,07724607 ! regulation of cellular localization GO:0060341 86 85 2,000 0,01885857 0,0808287 ! positive regulation of cell differentiation GO:0045597 87 85 2,000 0,01885857 0,08064116 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,01885857 0,08045449 ! muscle fiber development GO:0048747 32 32 1,000 0,01909873 0,0812909 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,01909873 0,0811036 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,01909873 0,08091715 ! kidney development GO:0001822 32 32 1,000 0,01909873 0,08073156 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,01909873 0,08054682 ! heart development GO:0007507 90 87 2,000 0,0200521 0,08437446 ! amino acid transport GO:0006865 33 33 1,000 0,02024534 0,08499352 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 1,000 0,02024534 0,08480035 ! regulation of neuron differentiation GO:0045664 34 33 1,000 0,02024534 0,08460806 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,02024534 0,08441664 ! regulation of actin filament length GO:0030832 34 34 1,000 0,02142017 0,08911372 ! ear development GO:0043583 34 34 1,000 0,02142017 0,08891302 ! muscle cell differentiation GO:0042692 35 34 1,000 0,02142017 0,08871321 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 0,02142017 0,0885143 ! secondary metabolic process GO:0019748 34 34 1,000 0,02142017 0,08831629 ! response to peptide hormone stimulus GO:0043434 36 34 1,000 0,02142017 0,08811915 ! brain development GO:0007420 91 90 2,000 0,02191937 0,08997195 ! negative regulation of cell cycle GO:0045786 92 91 2,000 0,02256236 0,09240538 ! acute inflammatory response GO:0002526 35 35 1,000 0,02262283 0,09244763 ! regulation of cellular component size GO:0032535 35 35 1,000 0,02262283 0,0922431 ! regulation of cytokine biosynthetic process GO:0042035 35 35 1,000 0,02262283 0,09203947 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,02262283 0,09183674 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,02262283 0,0916349 ! regulation of immune effector process GO:0002697 35 35 1,000 0,02262283 0,09143395 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 2,000 0,02321562 0,0936245 ! positive regulation of immune system process GO:0002684 92 92 2,000 0,02321562 0,09342008 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 0,02385291 0,0957754 ! regulation of mitosis GO:0007088 37 36 1,000 0,02385291 0,09556719 GO:0051783|regulation of nuclear division, ! female pregnancy GO:0007565 37 36 1,000 0,02385291 0,09535989 ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,02385291 0,09515348 ! gonad development GO:0008406 36 36 1,000 0,02385291 0,09494796 ! regulation of lipase activity GO:0060191 36 36 1,000 0,02385291 0,09474333 ! blood vessel development GO:0001568 95 94 2,000 0,02455302 0,09731444 ! meiosis GO:0007126 37 37 1,000 0,02510999 0,0993084 GO:0051327|M phase of meiotic cell cycle, ! ATP synthesis coupled electron transport GO:0042773 37 37 1,000 0,02510999 0,09909575 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! adaptive immune response GO:0002250 37 37 1,000 0,02510999 0,098884 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! vasculature development GO:0001944 97 96 2,000 0,02593156 0,10190162 ! positive regulation of secretion GO:0051047 39 38 1,000 0,02639369 0,10349695 ! cellular hormone metabolic process GO:0034754 39 38 1,000 0,02639369 0,10327721 ! cell-matrix adhesion GO:0007160 39 38 1,000 0,02639369 0,1030584 ! chromosome segregation GO:0007059 38 38 1,000 0,02639369 0,10284052 ! urogenital system development GO:0001655 38 38 1,000 0,02639369 0,10262356 ! meiotic cell cycle GO:0051321 38 38 1,000 0,02639369 0,10240751 ! axon guidance GO:0007411 39 38 1,000 0,02639369 0,10219237 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 0,02639369 0,10197813 ! blood circulation GO:0008015 99 98 2,000 0,02735121 0,10545667 GO:0003013|circulatory system process, ! positive regulation of protein modification process GO:0031401 39 39 1,000 0,0277036 0,10659235 ! intracellular protein transmembrane transport GO:0065002 39 39 1,000 0,0277036 0,10637028 ! regulation of MAPKKK cascade GO:0043408 41 39 1,000 0,0277036 0,10614914 ! positive regulation of T cell activation GO:0050870 39 39 1,000 0,0277036 0,10592891 ! response to other organism GO:0051707 101 100 2,000 0,02881194 0,10993872 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 0,02903934 0,11057747 ! organelle localization GO:0051640 41 40 1,000 0,02903934 0,11034948 ! leukocyte mediated immunity GO:0002443 41 41 1,000 0,03040051 0,11528424 ! respiratory electron transport chain GO:0022904 43 42 1,000 0,03178674 0,12029354 ! cell-substrate adhesion GO:0031589 43 42 1,000 0,03178674 0,12004704 ! development of primary sexual characteristics GO:0045137 42 42 1,000 0,03178674 0,11980155 ! protein ubiquitination GO:0016567 43 42 1,000 0,03178674 0,11955705 ! response to protein stimulus GO:0051789 42 42 1,000 0,03178674 0,11931356 ! one-carbon metabolic process GO:0006730 42 42 1,000 0,03178674 0,11907105 ! rRNA transcription GO:0009303 5 5 0,000 0,03299564 0,12334883 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,03299564 0,12309913 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,03299564 0,12285045 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,03299564 0,12260277 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,03299564 0,12235608 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,03299564 0,12211039 ! reproductive cellular process GO:0048610 5 5 0,000 0,03299564 0,12186568 ! positive regulation of glucose metabolic process GO:0010907 5 5 0,000 0,03299564 0,12162194 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,03299564 0,12137919 ! prostate gland development GO:0030850 5 5 0,000 0,03299564 0,12113739 ! water transport GO:0006833 5 5 0,000 0,03299564 0,12089656 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,03299564 0,12065669 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,03299564 0,12041777 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,03299564 0,12017979 ! glycerol metabolic process GO:0006071 5 5 0,000 0,03299564 0,11994275 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,03299564 0,11970664 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,03299564 0,11947146 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,03299564 0,1192372 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,03299564 0,11900386 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,03299564 0,11877143 ! filopodium assembly GO:0046847 7 5 0,000 0,03299564 0,11853991 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,03299564 0,11830928 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,03299564 0,11807956 ! GTP metabolic process GO:0046039 5 5 0,000 0,03299564 0,11785072 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,03299564 0,11762277 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,03299564 0,1173957 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,03299564 0,1171695 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,03299564 0,11694418 ! social behavior GO:0035176 5 5 0,000 0,03299564 0,11671972 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,03299564 0,11649612 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,03299564 0,11627337 ! memory GO:0007613 5 5 0,000 0,03299564 0,11605147 ! dopamine receptor signaling pathway GO:0007212 5 5 0,000 0,03299564 0,11583042 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,03299564 0,11561021 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,03299564 0,11539084 ! response to lipid GO:0033993 5 5 0,000 0,03299564 0,1151723 ! erythrocyte maturation GO:0043249 5 5 0,000 0,03299564 0,11495458 ! hippocampus development GO:0021766 6 5 0,000 0,03299564 0,11473768 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,03299564 0,1145216 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,03299564 0,11430634 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,03299564 0,11409188 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,03299564 0,11387823 ! mechanosensory behavior GO:0007638 5 5 0,000 0,03299564 0,11366537 ! heart looping GO:0001947 5 5 0,000 0,03299564 0,11345331 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,03299564 0,11324203 ! response to interferon-gamma GO:0034341 5 5 0,000 0,03299564 0,11303155 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,03299564 0,11282184 ! pH reduction GO:0045851 5 5 0,000 0,03299564 0,11261291 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,03299564 0,11240475 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,03299564 0,11219737 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,03299564 0,11199074 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,03299564 0,11178488 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,03299564 0,11157977 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,03299564 0,11137541 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,03299564 0,1111718 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,03299564 0,11096893 ! adrenal gland development GO:0030325 5 5 0,000 0,03299564 0,1107668 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,03299564 0,1105654 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,03299564 0,11036474 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,03299564 0,1101648 ! astrocyte differentiation GO:0048708 5 5 0,000 0,03299564 0,10996559 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,03299564 0,1097671 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,03299564 0,10956932 ! tyrosine metabolic process GO:0006570 5 5 0,000 0,03299564 0,10937225 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,03299564 0,10917589 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,03299564 0,10898024 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,03299564 0,10878528 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,03299564 0,10859102 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,03299564 0,10839745 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,03299564 0,10820458 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,03299564 0,10801238 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,03299564 0,10782087 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,03299564 0,10763004 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,03299564 0,10743988 ! response to ATP GO:0033198 5 5 0,000 0,03299564 0,10725039 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,03299564 0,10706157 ! regulation of appetite GO:0032098 5 5 0,000 0,03299564 0,10687341 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,03299564 0,10668592 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,03299564 0,10649908 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,03299564 0,10631289 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,03299564 0,10612735 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03299564 0,10594246 ! receptor clustering GO:0043113 5 5 0,000 0,03299564 0,10575821 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,03299564 0,1055746 ! actin cytoskeleton reorganization GO:0031532 5 5 0,000 0,03299564 0,10539163 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,03299564 0,10520929 ! retinol metabolic process GO:0042572 5 5 0,000 0,03299564 0,10502759 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,03299564 0,1048465 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,03299564 0,10466605 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,03299564 0,10448621 ! parturition GO:0007567 5 5 0,000 0,03299564 0,10430698 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03299564 0,10412838 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,03299564 0,10395038 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,03299564 0,10377299 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,03299564 0,1035962 ! protein heterooligomerization GO:0051291 5 5 0,000 0,03299564 0,10342002 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,03299564 0,10324443 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,03299564 0,10306944 ! oligodendrocyte development GO:0014003 5 5 0,000 0,03299564 0,10289505 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,03299564 0,10272124 ! activated T cell proliferation GO:0050798 5 5 0,000 0,03299564 0,10254801 ! interaction with symbiont GO:0051702 5 5 0,000 0,03299564 0,10237537 ! cellular extravasation GO:0045123 5 5 0,000 0,03299564 0,10220331 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,03299564 0,10203183 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,03299564 0,10186092 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,03299564 0,10169059 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,03299564 0,10152082 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,03299564 0,10135162 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,03299564 0,10118298 ! response to amine stimulus GO:0014075 5 5 0,000 0,03299564 0,1010149 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,03299564 0,10084738 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,03299564 0,10068042 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,03299564 0,100514 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,03299564 0,10034814 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,03299564 0,10018282 ! neuron recognition GO:0008038 5 5 0,000 0,03299564 0,10001805 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,03299564 0,09985381 ! decidualization GO:0046697 5 5 0,000 0,03299564 0,09969012 ! hair follicle maturation GO:0048820 5 5 0,000 0,03299564 0,09952696 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,03299564 0,09936433 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,03299564 0,09920224 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,03299564 0,09904067 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,03299564 0,09887963 ! postreplication repair GO:0006301 5 5 0,000 0,03299564 0,09871911 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,03299564 0,09855911 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,03299564 0,09839963 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03299564 0,09824067 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,03299564 0,09808221 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,03299564 0,09792427 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,03299564 0,09776684 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,03299564 0,09760991 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,03299564 0,09745348 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,03299564 0,09729756 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,03299564 0,09714213 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,03299564 0,0969872 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,03299564 0,09683276 ! sterol catabolic process GO:0016127 5 5 0,000 0,03299564 0,09667881 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,03299564 0,09652535 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,03299564 0,09637238 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,03299564 0,09621989 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,03299564 0,09606789 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,03299564 0,09591636 ! zymogen activation GO:0031638 5 5 0,000 0,03299564 0,09576531 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,03299564 0,09561474 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,03299564 0,09546463 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,03299564 0,095315 ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 0,03299564 0,09516584 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,03299564 0,09501714 ! nucleosome positioning GO:0016584 5 5 0,000 0,03299564 0,09486891 ! regulation of isotype switching GO:0045191 5 5 0,000 0,03299564 0,09472114 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,03299564 0,09457383 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,03299564 0,09442698 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,03299564 0,09428058 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,03299564 0,09413463 ! NADPH regeneration GO:0006740 5 5 0,000 0,03299564 0,09398914 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,03299564 0,09384409 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,03299564 0,09369949 ! musculoskeletal movement GO:0050881 5 5 0,000 0,03299564 0,09355534 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,03299564 0,09341163 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,03299564 0,09326836 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,03299564 0,09312553 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,03299564 0,09298314 GO:0046325|negative regulation of glucose import, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,03299564 0,09284118 ! male genitalia development GO:0030539 5 5 0,000 0,03299564 0,09269965 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,03299564 0,09255856 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,03299564 0,09241789 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,03299564 0,09227765 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,03299564 0,09213784 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,03299564 0,09199845 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,03299564 0,09185947 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,03299564 0,09172092 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,03299564 0,09158279 ! ATP catabolic process GO:0006200 5 5 0,000 0,03299564 0,09144507 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03299564 0,09130777 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,03299564 0,09117087 ! blastocyst formation GO:0001825 5 5 0,000 0,03299564 0,09103439 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,03299564 0,09089831 ! embryonic gut development GO:0048566 5 5 0,000 0,03299564 0,09076265 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,03299564 0,09062738 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,03299564 0,09049252 ! activation of innate immune response GO:0002218 5 5 0,000 0,03299564 0,09035806 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,03299564 0,09022399 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,03299564 0,09009033 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,03299564 0,08995706 ! muscle adaptation GO:0043500 5 5 0,000 0,03299564 0,08982418 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,03299564 0,0896917 ! embryonic heart tube development GO:0035050 5 5 0,000 0,03299564 0,08955961 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,03299564 0,0894279 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,03299564 0,08929658 ! defense response to fungus GO:0050832 5 5 0,000 0,03299564 0,08916565 ! lysogeny GO:0030069 5 5 0,000 0,03299564 0,0890351 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,03299564 0,08890493 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,03299564 0,08877514 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,03299564 0,08864573 ! establishment of cell polarity GO:0030010 5 5 0,000 0,03299564 0,0885167 ! mitochondrion localization GO:0051646 5 5 0,000 0,03299564 0,08838804 ! nucleus localization GO:0051647 5 5 0,000 0,03299564 0,08825976 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,03299564 0,08813184 ! reproductive structure development GO:0048608 43 43 1,000 0,03319764 0,08854304 ! mitochondrion organization GO:0007005 44 43 1,000 0,03319764 0,08841509 ! mRNA transport GO:0051028 44 44 1,000 0,03463283 0,09210434 ! protein import into nucleus GO:0006606 44 44 1,000 0,03463283 0,09197163 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,03463283 0,0918393 ! positive regulation of lymphocyte activation GO:0051251 44 44 1,000 0,03463283 0,09170734 ! regulation of actin cytoskeleton organization GO:0032956 46 45 1,000 0,03609195 0,09543396 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 0,03609195 0,09529723 ! steroid biosynthetic process GO:0006694 46 45 1,000 0,03609195 0,0951609 ! nuclear import GO:0051170 45 45 1,000 0,03609195 0,09502496 ! regulation of actin filament-based process GO:0032970 47 46 1,000 0,03757463 0,09878751 ! tube morphogenesis GO:0035239 47 46 1,000 0,03757463 0,09864678 ! sex differentiation GO:0007548 47 47 1,000 0,0390805 0,10245427 ! amine transport GO:0015837 47 47 1,000 0,0390805 0,10230874 ! rhythmic process GO:0048511 47 47 1,000 0,0390805 0,10216362 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,03946578 0,1030247 ! axon extension GO:0048675 7 6 0,000 0,03946578 0,10287898 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,03946578 0,10273367 ! tRNA modification GO:0006400 6 6 0,000 0,03946578 0,10258877 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,03946578 0,10244428 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,03946578 0,10230019 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,03946578 0,10215651 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,03946578 0,10201324 ! virus-host interaction GO:0019048 6 6 0,000 0,03946578 0,10187036 ! regulation of S phase GO:0033261 6 6 0,000 0,03946578 0,10172788 ! myotube differentiation GO:0014902 6 6 0,000 0,03946578 0,10158581 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,03946578 0,10144412 ! bone remodeling GO:0046849 6 6 0,000 0,03946578 0,10130284 ! N-glycan processing GO:0006491 6 6 0,000 0,03946578 0,10116194 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,03946578 0,10102144 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,03946578 0,10088133 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,03946578 0,1007416 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,03946578 0,10060226 ! RNA methylation GO:0001510 6 6 0,000 0,03946578 0,10046331 ! cartilage condensation GO:0001502 7 6 0,000 0,03946578 0,10032474 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,03946578 0,10018655 ! succinate metabolic process GO:0006105 7 6 0,000 0,03946578 0,10004874 ! artery development GO:0060840 6 6 0,000 0,03946578 0,09991131 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,03946578 0,09977426 ! bile acid metabolic process GO:0008206 6 6 0,000 0,03946578 0,09963758 ! androgen metabolic process GO:0008209 6 6 0,000 0,03946578 0,09950128 ! estrogen metabolic process GO:0008210 6 6 0,000 0,03946578 0,09936535 ! limbic system development GO:0021761 7 6 0,000 0,03946578 0,09922979 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,03946578 0,0990946 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 0,000 0,03946578 0,09895978 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,03946578 0,09882532 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,03946578 0,09869123 ! pathogenesis GO:0009405 6 6 0,000 0,03946578 0,0985575 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,03946578 0,09842414 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,03946578 0,09829113 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,03946578 0,09815848 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,03946578 0,0980262 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,03946578 0,09789426 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,03946578 0,09776268 ! arginine metabolic process GO:0006525 6 6 0,000 0,03946578 0,09763146 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,03946578 0,09750059 ! glutamate catabolic process GO:0006538 7 6 0,000 0,03946578 0,09737006 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,03946578 0,09723989 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,03946578 0,09711006 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,03946578 0,09698058 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,03946578 0,09685145 ! V(D)J recombination GO:0033151 6 6 0,000 0,03946578 0,09672266 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,03946578 0,09659421 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,03946578 0,0964661 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,03946578 0,09633833 ! regulation of heart rate GO:0002027 6 6 0,000 0,03946578 0,0962109 ! lipid digestion GO:0044241 6 6 0,000 0,03946578 0,0960838 ! asymmetric protein localization GO:0008105 6 6 0,000 0,03946578 0,09595704 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,03946578 0,09583062 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,03946578 0,09570452 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,03946578 0,09557876 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,03946578 0,09545333 ! ruffle organization GO:0031529 6 6 0,000 0,03946578 0,09532823 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,03946578 0,09520345 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,03946578 0,095079 ! neutral amino acid transport GO:0015804 6 6 0,000 0,03946578 0,09495488 ! L-amino acid transport GO:0015807 6 6 0,000 0,03946578 0,09483108 ! bone mineralization GO:0030282 6 6 0,000 0,03946578 0,0947076 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,03946578 0,09458444 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,03946578 0,09446161 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,03946578 0,09433909 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,03946578 0,09421689 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 0,03946578 0,094095 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,03946578 0,09397343 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,03946578 0,09385218 ! regulation of organ growth GO:0046620 6 6 0,000 0,03946578 0,09373123 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,03946578 0,0936106 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,03946578 0,09349028 ! response to dsRNA GO:0043331 6 6 0,000 0,03946578 0,09337027 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,03946578 0,09325056 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,03946578 0,09313116 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,03946578 0,09301207 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,03946578 0,09289328 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,03946578 0,09277479 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,03946578 0,09265661 ! multicellular organismal aging GO:0010259 6 6 0,000 0,03946578 0,09253872 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,03946578 0,09242114 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,03946578 0,09230385 ! erythrocyte development GO:0048821 6 6 0,000 0,03946578 0,09218687 ! renal water homeostasis GO:0003091 6 6 0,000 0,03946578 0,09207017 ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,03946578 0,09195378 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,03946578 0,09183767 ! ribosome assembly GO:0042255 6 6 0,000 0,03946578 0,09172186 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,03946578 0,09160634 ! diencephalon development GO:0021536 6 6 0,000 0,03946578 0,09149112 ! fucose catabolic process GO:0019317 6 6 0,000 0,03946578 0,09137618 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,03946578 0,09126153 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,03946578 0,09114716 ! regulation of lipid transport GO:0032368 6 6 0,000 0,03946578 0,09103309 ! regulation of cell division GO:0051302 6 6 0,000 0,03946578 0,0909193 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,03946578 0,09080579 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,03946578 0,09069256 ! neuroblast proliferation GO:0007405 6 6 0,000 0,03946578 0,09057962 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,03946578 0,09046696 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,03946578 0,09035458 ! regulation of glucose transport GO:0010827 6 6 0,000 0,03946578 0,09024248 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,03946578 0,09013065 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,03946578 0,09001911 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,03946578 0,08990783 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,03946578 0,08979684 ! lymph node development GO:0048535 6 6 0,000 0,03946578 0,08968611 ! organic cation transport GO:0015695 6 6 0,000 0,03946578 0,08957566 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,03946578 0,08946548 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,03946578 0,08935557 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 0,000 0,03946578 0,08924593 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,03946578 0,08913656 ! sperm-egg recognition GO:0035036 7 6 0,000 0,03946578 0,08902746 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,03946578 0,08891863 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,03946578 0,08881006 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,03946578 0,08870175 ! alditol metabolic process GO:0019400 6 6 0,000 0,03946578 0,08859371 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,03946578 0,08848593 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,03946578 0,08837842 ! maternal placenta development GO:0001893 6 6 0,000 0,03946578 0,08827116 ! regulation of embryonic development GO:0045995 6 6 0,000 0,03946578 0,08816417 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,03946578 0,08805743 ! regulation of cell cycle process GO:0010564 50 48 1,000 0,04060919 0,09049908 ! protein localization in nucleus GO:0034504 48 48 1,000 0,04060919 0,09038978 ! cell cycle arrest GO:0007050 49 49 1,000 0,04216036 0,09372923 ! cellular lipid catabolic process GO:0044242 50 49 1,000 0,04216036 0,09361631 ! response to nutrient GO:0007584 49 49 1,000 0,04216036 0,09350365 ! response to bacterium GO:0009617 50 49 1,000 0,04216036 0,09339127 ! positive regulation of cell activation GO:0050867 49 49 1,000 0,04216036 0,09327915 GO:0002696|positive regulation of leukocyte activation, ! regulation of defense response GO:0031347 50 50 1,000 0,04373364 0,096644 ! negative regulation of transport GO:0051051 51 50 1,000 0,04373364 0,09652826 ! RNA transport GO:0050658 50 50 1,000 0,04373364 0,09641279 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! regulation of neurogenesis GO:0050767 51 50 1,000 0,04373364 0,0962976 ! anatomical structure homeostasis GO:0060249 51 50 1,000 0,04373364 0,09618269 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,04532868 0,09957183 ! respiratory burst GO:0045730 7 7 0,000 0,04589356 0,10069267 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,04589356 0,10057294 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,04589356 0,10045349 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,04589356 0,10033433 ! positive regulation of cellular catabolic process GO:0031331 7 7 0,000 0,04589356 0,10021545 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,04589356 0,10009685 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,04589356 0,09997853 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,04589356 0,0998605 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,04589356 0,09974274 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,04589356 0,09962525 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,04589356 0,09950805 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,04589356 0,09939112 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,04589356 0,09927446 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,04589356 0,09915808 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,04589356 0,09904197 ! axis specification GO:0009798 7 7 0,000 0,04589356 0,09892613 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,04589356 0,09881056 ! visual behavior GO:0007632 7 7 0,000 0,04589356 0,09869526 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,04589356 0,09858023 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,04589356 0,09846547 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,04589356 0,09835098 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,04589356 0,09823675 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,04589356 0,09812278 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,04589356 0,09800908 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,04589356 0,09789565 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,04589356 0,09778247 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,04589356 0,09766956 ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,04589356 0,09755691 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,04589356 0,09744452 ! protein targeting to ER GO:0045047 8 7 0,000 0,04589356 0,09733238 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,04589356 0,0972205 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,04589356 0,09710889 ! endoderm development GO:0007492 7 7 0,000 0,04589356 0,09699752 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,04589356 0,09688641 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,04589356 0,09677556 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 0,04589356 0,09666496 ! response to hexose stimulus GO:0009746 7 7 0,000 0,04589356 0,09655461 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,04589356 0,09644451 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,04589356 0,09633467 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,04589356 0,09622507 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,04589356 0,09611573 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,04589356 0,09600663 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,04589356 0,09589778 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,04589356 0,09578917 ! response to X-ray GO:0010165 7 7 0,000 0,04589356 0,09568081 ! regulation of intracellular pH GO:0051453 7 7 0,000 0,04589356 0,0955727 ! UV protection GO:0009650 7 7 0,000 0,04589356 0,09546483 ! DNA integration GO:0015074 7 7 0,000 0,04589356 0,0953572 ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 0,000 0,04589356 0,09524982 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,04589356 0,09514268 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,04589356 0,09503577 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,04589356 0,09492911 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,04589356 0,09482269 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,04589356 0,09471651 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,04589356 0,09461056 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,04589356 0,09450485 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,04589356 0,09439937 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,04589356 0,09429414 ! axon cargo transport GO:0008088 7 7 0,000 0,04589356 0,09418913 ! eating behavior GO:0042755 7 7 0,000 0,04589356 0,09408436 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,04589356 0,09397982 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,04589356 0,09387552 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,04589356 0,09377144 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,04589356 0,0936676 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,04589356 0,09356398 ! cranial nerve development GO:0021545 7 7 0,000 0,04589356 0,0934606 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,04589356 0,09335744 ! induction of an organ GO:0001759 7 7 0,000 0,04589356 0,09325451 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,04589356 0,09315181 GO:0002263|cell activation during immune response, ! autonomic nervous system development GO:0048483 7 7 0,000 0,04589356 0,09304933 ! intracellular lipid transport GO:0032365 7 7 0,000 0,04589356 0,09294708 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,04589356 0,09284505 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,04589356 0,09274324 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,04589356 0,09264166 ! natural killer cell activation GO:0030101 7 7 0,000 0,04589356 0,09254031 ! NADP metabolic process GO:0006739 7 7 0,000 0,04589356 0,09243917 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,04589356 0,09233825 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,04589356 0,09223756 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,04589356 0,09213708 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,04589356 0,09203682 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,04589356 0,09193678 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,04589356 0,09183696 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,04589356 0,09173735 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,04589356 0,09163796 ! cell-cell recognition GO:0009988 8 7 0,000 0,04589356 0,09153879 ! hormone catabolic process GO:0042447 7 7 0,000 0,04589356 0,09143983 ! dopamine metabolic process GO:0042417 7 7 0,000 0,04589356 0,09134108 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,04589356 0,09124255 ! oxygen transport GO:0015671 7 7 0,000 0,04589356 0,09114422 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,04589356 0,09104611 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,04589356 0,09094821 ! regulation of axon extension GO:0030516 7 7 0,000 0,04589356 0,09085053 ! cell killing GO:0001906 7 7 0,000 0,04589356 0,09075305 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,04589356 0,09065578 ! adult feeding behavior GO:0008343 7 7 0,000 0,04589356 0,09055871 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,04589356 0,09046186 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,04589356 0,09036521 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,04589356 0,09026877 ! response to cold GO:0009409 7 7 0,000 0,04589356 0,09017254 ! RNA localization GO:0006403 52 52 1,000 0,04694515 0,09214048 ! cell fate commitment GO:0045165 52 52 1,000 0,04694515 0,09204246 ! regulation of GTPase activity GO:0043087 53 52 1,000 0,04694515 0,09194465 ! tRNA metabolic process GO:0006399 53 53 1,000 0,04858269 0,09505085 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 1,000 0,04858269 0,09495005 ! protein amino acid dephosphorylation GO:0006470 55 54 1,000 0,05024097 0,09808697 ! hormone metabolic process GO:0042445 55 54 1,000 0,05024097 0,09798317 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,05191964 0,10114999 ! protein modification by small protein conjugation or removal GO:0070647 56 55 1,000 0,05191964 0,10104318 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,05227926 0,10163574 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,05227926 0,10152864 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,05227926 0,10142177 ! superoxide anion generation GO:0042554 8 8 0,000 0,05227926 0,10131512 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,05227926 0,1012087 ! cGMP metabolic process GO:0046068 8 8 0,000 0,05227926 0,1011025 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,05227926 0,10099652 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,05227926 0,10089076 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,05227926 0,10078523 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,05227926 0,10067992 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,05227926 0,10057482 ! zinc ion transport GO:0006829 8 8 0,000 0,05227926 0,10046995 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,05227926 0,10036529 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,05227926 0,10026085 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,05227926 0,10015663 ! lipid localization GO:0010876 8 8 0,000 0,05227926 0,10005263 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,05227926 0,09994884 ! response to cAMP GO:0051591 8 8 0,000 0,05227926 0,09984526 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,05227926 0,0997419 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,05227926 0,09963876 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,05227926 0,09953583 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,05227926 0,09943311 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,05227926 0,0993306 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,05227926 0,0992283 ! sensory perception of taste GO:0050909 8 8 0,000 0,05227926 0,09912621 ! organelle fusion GO:0048284 8 8 0,000 0,05227926 0,09902434 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,05227926 0,09892267 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,05227926 0,09882121 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,05227926 0,09871996 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,05227926 0,09861891 ! sperm motility GO:0030317 8 8 0,000 0,05227926 0,09851808 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,05227926 0,09841745 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,05227926 0,09831702 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,05227926 0,0982168 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,05227926 0,09811678 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,05227926 0,09801697 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,05227926 0,09791736 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,05227926 0,09781795 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,05227926 0,09771874 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,05227926 0,09761974 ! fructose metabolic process GO:0006000 8 8 0,000 0,05227926 0,09752093 ! mannose metabolic process GO:0006013 9 8 0,000 0,05227926 0,09742232 ! NAD metabolic process GO:0019674 8 8 0,000 0,05227926 0,09732392 ! plasma membrane fusion GO:0045026 8 8 0,000 0,05227926 0,09722571 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,05227926 0,0971277 ! response to fungus GO:0009620 8 8 0,000 0,05227926 0,09702989 ! stem cell differentiation GO:0048863 8 8 0,000 0,05227926 0,09693227 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,05227926 0,09683485 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,05227926 0,09673763 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,05227926 0,0966406 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,05227926 0,09654377 ! regulation of vasodilation GO:0042312 8 8 0,000 0,05227926 0,09644713 ! vasoconstriction GO:0042310 8 8 0,000 0,05227926 0,09635068 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,05227926 0,09625442 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,05227926 0,09615836 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,05227926 0,09606249 ! sensory perception of pain GO:0019233 8 8 0,000 0,05227926 0,09596681 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,05227926 0,09587132 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,05227926 0,09577602 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,05227926 0,09568091 ! chromatin silencing GO:0006342 8 8 0,000 0,05227926 0,09558599 ! tissue regeneration GO:0042246 8 8 0,000 0,05227926 0,09549126 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,05227926 0,09539671 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,05227926 0,09530235 ! water homeostasis GO:0030104 8 8 0,000 0,05227926 0,09520818 ! cofactor transport GO:0051181 8 8 0,000 0,05227926 0,09511419 ! acid secretion GO:0046717 8 8 0,000 0,05227926 0,09502039 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,05227926 0,09492678 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,05227926 0,09483335 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,05227926 0,0947401 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,05227926 0,09464703 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 0,000 0,05227926 0,09455415 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,05227926 0,09446145 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,05227926 0,09436893 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,05227926 0,09427659 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,05227926 0,09418444 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,05227926 0,09409246 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,05227926 0,09400066 ! developmental induction GO:0031128 8 8 0,000 0,05227926 0,09390904 GO:0045168|cell-cell signaling involved in cell fate specification, ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,05227926 0,0938176 ! cytoplasmic sequestering of protein GO:0051220 8 8 0,000 0,05227926 0,09372634 ! peptide hormone processing GO:0016486 8 8 0,000 0,05227926 0,09363526 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,05227926 0,09354435 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,05227926 0,09345362 ! extracellular structure organization GO:0043062 56 56 1,000 0,05361837 0,09575452 ! regulation of nervous system development GO:0051960 57 56 1,000 0,05361837 0,09566182 ! lactation GO:0007595 10 9 0,000 0,05862314 0,1044898 ! embryonic pattern specification GO:0009880 10 9 0,000 0,05862314 0,10438884 ! positive regulation of cell size GO:0045793 9 9 0,000 0,05862314 0,10428808 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,05862314 0,10418751 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,05862314 0,10408714 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,05862314 0,10398696 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,05862314 0,10388697 ! viral genome replication GO:0019079 9 9 0,000 0,05862314 0,10378718 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,05862314 0,10368757 ! copper ion transport GO:0006825 9 9 0,000 0,05862314 0,10358816 ! lipid phosphorylation GO:0046834 9 9 0,000 0,05862314 0,10348894 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,05862314 0,10338991 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,05862314 0,10329106 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,05862314 0,10319241 ! RNA polyadenylation GO:0043631 9 9 0,000 0,05862314 0,10309394 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,05862314 0,10299567 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,05862314 0,10289757 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,05862314 0,10279967 ! phospholipid efflux GO:0033700 9 9 0,000 0,05862314 0,10270195 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,05862314 0,10260442 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,05862314 0,10250707 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,05862314 0,10240991 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,05862314 0,10231293 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,05862314 0,10221613 ! methionine metabolic process GO:0006555 9 9 0,000 0,05862314 0,10211952 ! glutamine metabolic process GO:0006541 9 9 0,000 0,05862314 0,10202309 ! cerebral cortex development GO:0021987 9 9 0,000 0,05862314 0,10192684 ! response to osmotic stress GO:0006970 9 9 0,000 0,05862314 0,10183078 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,05862314 0,10173489 ! central nervous system neuron development GO:0021954 10 9 0,000 0,05862314 0,10163918 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,05862314 0,10154366 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,05862314 0,10144831 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,05862314 0,10135315 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,05862314 0,10125816 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,05862314 0,10116335 ! L-glutamate transport GO:0015813 9 9 0,000 0,05862314 0,10106871 GO:0015800|acidic amino acid transport, ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,05862314 0,10097425 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,05862314 0,10087997 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,05862314 0,10078587 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,05862314 0,10069194 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,05862314 0,10059819 ! positive regulation of protein import into nucleus GO:0042307 9 9 0,000 0,05862314 0,10050461 ! DNA replication initiation GO:0006270 9 9 0,000 0,05862314 0,1004112 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,05862314 0,10031797 GO:0006692|prostanoid metabolic process, ! regulation of cellular pH GO:0030641 9 9 0,000 0,05862314 0,10022491 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,05862314 0,10013202 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,05862314 0,10003931 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,05862314 0,09994676 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,05862314 0,09985439 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,05862314 0,09976219 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,05862314 0,09967016 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,05862314 0,0995783 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,05862314 0,0994866 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,05862314 0,09939508 ! purine base metabolic process GO:0006144 9 9 0,000 0,05862314 0,09930372 ! gas transport GO:0015669 9 9 0,000 0,05862314 0,09921254 ! cholesterol efflux GO:0033344 9 9 0,000 0,05862314 0,09912152 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,05862314 0,09903066 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,05862314 0,09893998 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,05862314 0,09884945 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,05862314 0,0987591 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,05862314 0,09866891 ! actin filament-based movement GO:0030048 9 9 0,000 0,05862314 0,09857888 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,05862314 0,09848902 ! dephosphorylation GO:0016311 60 59 1,000 0,05883168 0,09874935 ! carboxylic acid transport GO:0046942 59 59 1,000 0,05883168 0,0986595 GO:0015849|organic acid transport, ! regulation of cell development GO:0060284 60 59 1,000 0,05883168 0,0985698 ! protein localization in organelle GO:0033365 59 59 1,000 0,05883168 0,09848028 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 1,000 0,0606074 0,10136066 ! cellular respiration GO:0045333 62 61 1,000 0,06240157 0,10426664 ! positive regulation of cellular protein metabolic process GO:0032270 61 61 1,000 0,06240157 0,10417219 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,06421388 0,10710061 GO:0060429|epithelium development, ! protein import GO:0017038 62 62 1,000 0,06421388 0,10700377 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,06492548 0,10809183 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,06492548 0,10799427 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 0,000 0,06492548 0,10789689 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,06492548 0,10779969 ! regulation of glucose metabolic process GO:0010906 10 10 0,000 0,06492548 0,10770266 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,06492548 0,1076058 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,06492548 0,10750912 ! neuron maturation GO:0042551 10 10 0,000 0,06492548 0,10741262 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,06492548 0,10731628 ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,06492548 0,10722012 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,06492548 0,10712413 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,06492548 0,10702831 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,06492548 0,10693267 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,06492548 0,10683719 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 0,000 0,06492548 0,10674189 ! inositol metabolic process GO:0006020 10 10 0,000 0,06492548 0,10664675 ! cAMP metabolic process GO:0046058 10 10 0,000 0,06492548 0,10655178 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,06492548 0,10645699 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,06492548 0,10636236 ! glial cell development GO:0021782 10 10 0,000 0,06492548 0,1062679 ! phototransduction GO:0007602 11 10 0,000 0,06492548 0,10617361 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,06492548 0,10607948 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,06492548 0,10598552 ! fat cell differentiation GO:0045444 10 10 0,000 0,06492548 0,10589173 ! myoblast differentiation GO:0045445 10 10 0,000 0,06492548 0,1057981 ! centrosome cycle GO:0007098 10 10 0,000 0,06492548 0,10570464 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,06492548 0,10561134 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,06492548 0,10551821 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,06492548 0,10542525 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,06492548 0,10533244 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,06492548 0,1052398 ! protein polyubiquitination GO:0000209 10 10 0,000 0,06492548 0,10514732 ! glutamate metabolic process GO:0006536 11 10 0,000 0,06492548 0,10505501 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,06492548 0,10496285 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,06492548 0,10487086 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,06492548 0,10477903 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,06492548 0,10468736 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,06492548 0,10459585 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,06492548 0,1045045 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,06492548 0,10441331 ! embryo implantation GO:0007566 11 10 0,000 0,06492548 0,10432228 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,06492548 0,10423141 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,06492548 0,10414069 GO:0070585|protein localization in mitochondrion, ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,06492548 0,10405013 ! protein export from nucleus GO:0006611 10 10 0,000 0,06492548 0,10395973 ! negative regulation of immune response GO:0050777 10 10 0,000 0,06492548 0,10386949 ! cytolysis GO:0019835 10 10 0,000 0,06492548 0,1037794 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,06492548 0,10368947 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,06492548 0,1035997 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,06492548 0,10351008 ! histone deacetylation GO:0016575 10 10 0,000 0,06492548 0,10342062 ! mRNA splice site selection GO:0006376 11 10 0,000 0,06492548 0,10333131 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,06492548 0,10324215 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,06492548 0,10315315 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,06492548 0,1030643 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,06492548 0,10297561 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,06492548 0,10288706 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,06492548 0,10279867 ! regulation of epidermis development GO:0045682 10 10 0,000 0,06492548 0,10271043 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,06492548 0,10262234 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,06492548 0,10253441 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,06492548 0,10244662 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,06492548 0,10235899 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,06492548 0,1022715 ! nerve development GO:0021675 10 10 0,000 0,06492548 0,10218416 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,06492548 0,10209697 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,06492548 0,10200994 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,06492548 0,10192304 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,06492548 0,1018363 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,06492548 0,10174971 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,06492548 0,10166326 ! protein stabilization GO:0050821 10 10 0,000 0,06492548 0,10157696 ! regulation of secretion GO:0051046 65 63 1,000 0,066044 0,10323927 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,066044 0,10315178 ! glycerolipid metabolic process GO:0046486 65 64 1,000 0,06789164 0,10594775 ! regulation of cytoskeleton organization GO:0051493 66 64 1,000 0,06789164 0,10585812 ! positive regulation of protein metabolic process GO:0051247 64 64 1,000 0,06789164 0,10576864 ! positive regulation of cellular component organization GO:0051130 65 65 1,000 0,06975649 0,10858211 ! protein secretion GO:0009306 11 11 0,000 0,07118653 0,11071458 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,07118653 0,11062123 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,07118653 0,11052803 ! negative regulation of defense response GO:0031348 11 11 0,000 0,07118653 0,11043499 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,07118653 0,11034211 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,07118653 0,11024939 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,07118653 0,11015682 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,07118653 0,11006441 ! skin development GO:0043588 11 11 0,000 0,07118653 0,10997215 ! signal complex assembly GO:0007172 11 11 0,000 0,07118653 0,10988004 ! microtubule-based transport GO:0010970 11 11 0,000 0,07118653 0,10978809 ! endothelial cell migration GO:0043542 11 11 0,000 0,07118653 0,1096963 ! peroxisomal transport GO:0043574 11 11 0,000 0,07118653 0,10960466 ! protein amino acid methylation GO:0006479 11 11 0,000 0,07118653 0,10951317 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,07118653 0,10942183 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,07118653 0,10933064 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,07118653 0,10923961 ! T cell proliferation GO:0042098 11 11 0,000 0,07118653 0,10914873 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,07118653 0,109058 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,07118653 0,10896742 ! spinal cord development GO:0021510 11 11 0,000 0,07118653 0,10887699 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,07118653 0,10878671 ! smooth muscle contraction GO:0006939 11 11 0,000 0,07118653 0,10869658 ! cellular response to starvation GO:0009267 11 11 0,000 0,07118653 0,1086066 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,07118653 0,10851677 ! digestive system process GO:0022600 11 11 0,000 0,07118653 0,10842709 ! mitotic spindle organization GO:0007052 11 11 0,000 0,07118653 0,10833755 ! fucose metabolic process GO:0006004 11 11 0,000 0,07118653 0,10824816 ! membrane budding GO:0006900 11 11 0,000 0,07118653 0,10815892 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,07118653 0,10806983 ! monoamine transport GO:0015844 11 11 0,000 0,07118653 0,10798088 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,07118653 0,10789208 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,07118653 0,10780343 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,07118653 0,10771492 ! body fluid secretion GO:0007589 11 11 0,000 0,07118653 0,10762656 ! G1/S transition checkpoint GO:0031575 12 11 0,000 0,07118653 0,10753834 ! intermediate filament-based process GO:0045103 11 11 0,000 0,07118653 0,10745026 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,07118653 0,10736233 GO:0060415|muscle tissue morphogenesis, ! interaction with host GO:0051701 11 11 0,000 0,07118653 0,10727455 ! membrane depolarization GO:0051899 11 11 0,000 0,07118653 0,10718691 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,07118653 0,10709941 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,07118653 0,10701205 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,07118653 0,10692484 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,07118653 0,10683776 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 0,000 0,07118653 0,10675083 GO:0006109|regulation of carbohydrate metabolic process, ! vitamin transport GO:0051180 11 11 0,000 0,07118653 0,10666404 ! muscle maintenance GO:0046716 12 11 0,000 0,07118653 0,10657739 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,07118653 0,10649089 ! steroid catabolic process GO:0006706 11 11 0,000 0,07118653 0,10640452 ! endocrine process GO:0050886 11 11 0,000 0,07118653 0,10631829 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,07118653 0,1062322 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,07118653 0,10614626 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,07118653 0,10606045 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,07163826 0,10664726 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 0,07163826 0,10656118 ! Golgi vesicle transport GO:0048193 67 67 1,000 0,07353663 0,10929678 ! sensory perception of sound GO:0007605 71 69 1,000 0,07738204 0,1149195 GO:0050954|sensory perception of mechanical stimulus, ! response to nutrient levels GO:0031667 69 69 1,000 0,07738204 0,11482697 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,07740656 0,11477096 ! translational initiation GO:0006413 12 12 0,000 0,07740656 0,1146787 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,07740656 0,11458658 ! initiation of viral infection GO:0019059 12 12 0,000 0,07740656 0,11449462 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,07740656 0,1144028 ! iron ion transport GO:0006826 13 12 0,000 0,07740656 0,11431114 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,07740656 0,11421961 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,07740656 0,11412824 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,07740656 0,11403701 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,07740656 0,11394592 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,07740656 0,11385499 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,07740656 0,11376419 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,07740656 0,11367354 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,07740656 0,11358304 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,07740656 0,11349268 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,07740656 0,11340246 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,07740656 0,11331239 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,07740656 0,11322246 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,07740656 0,11313267 ! retinoid metabolic process GO:0001523 12 12 0,000 0,07740656 0,11304302 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,07740656 0,11295352 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,07740656 0,11286416 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,07740656 0,11277494 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,07740656 0,11268586 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,07740656 0,11259692 ! vacuolar transport GO:0007034 12 12 0,000 0,07740656 0,11250812 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,07740656 0,11241946 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,07740656 0,11233094 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,07740656 0,11224256 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,07740656 0,11215432 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,07740656 0,11206622 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,07740656 0,11197826 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,07740656 0,11189043 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,07740656 0,11180274 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,07740656 0,11171519 ! pallium development GO:0021543 13 12 0,000 0,07740656 0,11162778 ! cell fate determination GO:0001709 12 12 0,000 0,07740656 0,1115405 ! G1 phase GO:0051318 13 12 0,000 0,07740656 0,11145336 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,07740656 0,11136635 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,07740656 0,11127948 ! detection of light stimulus GO:0009583 13 12 0,000 0,07740656 0,11119275 ! synaptogenesis GO:0007416 12 12 0,000 0,07740656 0,11110615 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,07740656 0,11101969 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,07740656 0,11093336 ! heme biosynthetic process GO:0006783 12 12 0,000 0,07740656 0,11084716 ! spermatid differentiation GO:0048515 13 12 0,000 0,07740656 0,1107611 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,07740656 0,11067517 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,07740656 0,11058938 ! neural tube closure GO:0001843 13 12 0,000 0,07740656 0,11050372 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,07740656 0,11041819 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,07740656 0,11033279 ! growth GO:0040007 70 70 1,000 0,07932849 0,11298486 ! oxidative phosphorylation GO:0006119 71 71 1,000 0,0812904 0,11568973 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,0812904 0,11560047 GO:0006874|cellular calcium ion homeostasis, ! negative regulation of signal transduction GO:0009968 71 71 1,000 0,0812904 0,11551134 ! secretion by cell GO:0032940 75 72 1,000 0,08326747 0,11822954 ! positive regulation of hydrolase activity GO:0051345 72 72 1,000 0,08326747 0,11813853 ! sensory organ development GO:0007423 72 72 1,000 0,08326747 0,11804765 ! response to extracellular stimulus GO:0009991 72 72 1,000 0,08326747 0,11795692 ! regulation of cytokine production GO:0001817 72 72 1,000 0,08326747 0,11786632 ! positive regulation of DNA replication GO:0045740 14 13 0,000 0,08358584 0,11822618 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,08358584 0,11813551 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,08358584 0,11804499 ! phenol metabolic process GO:0018958 13 13 0,000 0,08358584 0,1179546 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,08358584 0,11786435 ! gluconeogenesis GO:0006094 13 13 0,000 0,08358584 0,11777424 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,08358584 0,11768427 GO:0019692|deoxyribose phosphate metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,08358584 0,11759444 ! keratinization GO:0031424 13 13 0,000 0,08358584 0,11750474 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,08358584 0,11741518 ! patterning of blood vessels GO:0001569 13 13 0,000 0,08358584 0,11732575 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,08358584 0,11723646 ! regulation of innate immune response GO:0045088 13 13 0,000 0,08358584 0,11714731 ! negative regulation of DNA replication GO:0008156 13 13 0,000 0,08358584 0,11705829 ! autophagy GO:0006914 13 13 0,000 0,08358584 0,11696941 ! receptor metabolic process GO:0043112 14 13 0,000 0,08358584 0,11688066 ! actin filament bundle formation GO:0051017 13 13 0,000 0,08358584 0,11679205 ! negative regulation of protein catabolic process GO:0042177 13 13 0,000 0,08358584 0,11670357 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,08358584 0,11661522 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,08358584 0,11652701 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,08358584 0,11643894 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,08358584 0,11635099 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,08358584 0,11626318 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,08358584 0,1161755 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,08358584 0,11608795 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,08358584 0,11600054 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,08358584 0,11591325 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,08358584 0,1158261 ! vasodilation GO:0042311 14 13 0,000 0,08358584 0,11573908 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,08358584 0,11565219 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,08358584 0,11556542 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,08358584 0,11547879 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,08358584 0,11539229 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,08358584 0,11530592 ! immunoglobulin production GO:0002377 13 13 0,000 0,08358584 0,11521968 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,08358584 0,11513357 ! negative regulation of intracellular transport GO:0032387 13 13 0,000 0,08358584 0,11504758 ! cell-cell junction organization GO:0045216 13 13 0,000 0,08358584 0,11496172 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,08358584 0,114876 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,08358584 0,1147904 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,08358584 0,11470492 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,08358584 0,11461958 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,08358584 0,11453436 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,08358584 0,11444927 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,08358584 0,1143643 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,08358584 0,11427946 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,08358584 0,11419475 ! blastocyst development GO:0001824 13 13 0,000 0,08358584 0,11411016 ! telomere organization GO:0032200 13 13 0,000 0,08358584 0,11402569 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,08358584 0,11394135 ! regulation of amine transport GO:0051952 13 13 0,000 0,08358584 0,11385714 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,08358584 0,11377305 ! protein tetramerization GO:0051262 13 13 0,000 0,08358584 0,11368909 ! electron transport chain GO:0022900 75 74 1,000 0,087266 0,11860711 ! neuron fate commitment GO:0048663 14 14 0,000 0,08972463 0,12185888 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,08972463 0,12176914 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,08972463 0,12167954 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,08972463 0,12159007 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,08972463 0,12150073 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,08972463 0,12141152 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,08972463 0,12132245 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,08972463 0,1212335 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,08972463 0,12114469 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,08972463 0,121056 ! vesicle docking GO:0048278 14 14 0,000 0,08972463 0,12096744 ! superoxide metabolic process GO:0006801 15 14 0,000 0,08972463 0,12087902 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,08972463 0,12079072 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,08972463 0,12070255 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,08972463 0,12061451 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,08972463 0,1205266 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,08972463 0,12043882 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,08972463 0,12035116 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,08972463 0,12026363 GO:0033189|response to vitamin A, ! lysosome organization GO:0007040 14 14 0,000 0,08972463 0,12017623 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,08972463 0,12008896 ! primary neural tube formation GO:0014020 15 14 0,000 0,08972463 0,12000181 ! peptide cross-linking GO:0018149 14 14 0,000 0,08972463 0,11991479 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,08972463 0,1198279 ! base-excision repair GO:0006284 14 14 0,000 0,08972463 0,11974113 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,08972463 0,11965448 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,08972463 0,11956797 ! formation of primary germ layer GO:0001704 14 14 0,000 0,08972463 0,11948157 GO:0001707|mesoderm formation, ! collagen fibril organization GO:0030199 14 14 0,000 0,08972463 0,1193953 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,08972463 0,11930916 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,08972463 0,11922314 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,08972463 0,11913724 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,08972463 0,11905147 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,08972463 0,11896582 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,08972463 0,1188803 ! negative regulation of cell communication GO:0010648 76 76 1,000 0,09132189 0,12090966 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,09337066 0,12353348 ! microtubule-based movement GO:0007018 82 78 1,000 0,09543297 0,12617142 ! positive regulation of protein kinase cascade GO:0010740 79 78 1,000 0,09543297 0,12608098 ! metal ion homeostasis GO:0055065 78 78 1,000 0,09543297 0,12599066 ! regulation of immune response GO:0050776 78 78 1,000 0,09543297 0,12590048 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,09582318 0,12632484 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,09582318 0,12623455 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,09582318 0,12614438 ! positive regulation of ossification GO:0045778 15 15 0,000 0,09582318 0,12605434 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,09582318 0,12596443 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,09582318 0,12587465 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,09582318 0,12578499 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,09582318 0,12569547 ! response to vitamin GO:0033273 15 15 0,000 0,09582318 0,12560607 ! regulation of transcription factor import into nucleus GO:0042990 15 15 0,000 0,09582318 0,12551679 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,09582318 0,12542765 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,09582318 0,12533863 ! insulin receptor signaling pathway GO:0008286 17 15 0,000 0,09582318 0,12524974 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,09582318 0,12516097 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,09582318 0,12507233 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,09582318 0,12498381 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,09582318 0,12489542 ! heme metabolic process GO:0042168 15 15 0,000 0,09582318 0,12480716 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,09582318 0,12471902 ! chromosome condensation GO:0030261 15 15 0,000 0,09582318 0,124631 ! response to starvation GO:0042594 15 15 0,000 0,09582318 0,12454311 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,09582318 0,12445534 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,09582318 0,1243677 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,09582318 0,12428018 GO:0030500|regulation of bone mineralization, ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,09582318 0,12419278 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,09582318 0,1241055 ! phospholipid transport GO:0015914 15 15 0,000 0,09582318 0,12401835 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,09582318 0,12393132 ! glutathione metabolic process GO:0006749 16 15 0,000 0,09582318 0,12384441 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,09582318 0,12375762 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,09582318 0,12367096 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,09582318 0,12358442 ! negative regulation of transcription factor activity GO:0043433 16 15 0,000 0,09582318 0,12349799 GO:0090048|negative regulation of transcription regulator activity, ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,09582318 0,12341169 ! protein homooligomerization GO:0051260 15 15 0,000 0,09582318 0,12332551 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,09582318 0,12323945 ! nuclear transport GO:0051169 79 79 1,000 0,09750855 0,12531956 GO:0006913|nucleocytoplasmic transport, ! negative regulation of adenylate cyclase activity GO:0007194 16 16 0,000 0,10188176 0,13084884 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! alkaloid metabolic process GO:0009820 16 16 0,000 0,10188176 0,13075772 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,10188176 0,13066673 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,10188176 0,13057586 ! learning GO:0007612 16 16 0,000 0,10188176 0,13048512 ! circadian rhythm GO:0007623 16 16 0,000 0,10188176 0,13039451 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,10188176 0,13030402 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,10188176 0,13021365 ! vacuole organization GO:0007033 16 16 0,000 0,10188176 0,13012341 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,10188176 0,1300333 ! vesicle targeting GO:0006903 17 16 0,000 0,10188176 0,12994331 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,10188176 0,12985345 ! iron ion homeostasis GO:0055072 16 16 0,000 0,10188176 0,12976371 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,10188176 0,12967409 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,10188176 0,1295846 ! cell fate specification GO:0001708 16 16 0,000 0,10188176 0,12949523 ! pentose metabolic process GO:0019321 16 16 0,000 0,10188176 0,12940599 ! fatty acid transport GO:0015908 16 16 0,000 0,10188176 0,12931686 ! cellular response to nutrient levels GO:0031669 16 16 0,000 0,10188176 0,12922786 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,10188176 0,12913899 ! cofactor catabolic process GO:0051187 16 16 0,000 0,10188176 0,12905023 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,10188176 0,1289616 ! polyol metabolic process GO:0019751 16 16 0,000 0,10188176 0,12887309 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,10188176 0,1287847 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,10188176 0,12869643 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,10188176 0,12860828 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,10188176 0,12852025 GO:0001841|neural tube formation, ! positive regulation of catabolic process GO:0009896 16 16 0,000 0,10188176 0,12843234 ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,10188176 0,12834456 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,10188176 0,12825689 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,10188176 0,12816934 ! regulation of coagulation GO:0050818 17 16 0,000 0,10188176 0,12808192 ! regulation of fibroblast proliferation GO:0048145 17 17 0,000 0,10790062 0,13555613 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,10790062 0,13546379 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,10790062 0,13537157 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,10790062 0,13527948 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,10790062 0,13518752 ! leukocyte adhesion GO:0007159 17 17 0,000 0,10790062 0,13509568 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,10790062 0,13500397 ! sensory perception of smell GO:0007608 17 17 0,000 0,10790062 0,13491238 ! glucose transport GO:0015758 17 17 0,000 0,10790062 0,13482091 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,10790062 0,13472957 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,10790062 0,13463835 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,10790062 0,13454725 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,10790062 0,13445628 ! neural crest cell development GO:0014032 19 17 0,000 0,10790062 0,13436543 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 18 17 0,000 0,10790062 0,13427471 GO:0050768|negative regulation of neurogenesis, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,10790062 0,1341841 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,10790062 0,13409362 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,10790062 0,13400326 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,10790062 0,13391303 ! adult locomotory behavior GO:0008344 17 17 0,000 0,10790062 0,13382291 ! embryonic organ development GO:0048568 17 17 0,000 0,10790062 0,13373291 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,10790062 0,13364304 ! liver development GO:0001889 17 17 0,000 0,10790062 0,13355329 ! gene silencing GO:0016458 17 17 0,000 0,10790062 0,13346365 ! organophosphate metabolic process GO:0019637 87 86 1,000 0,11238763 0,13892046 GO:0006644|phospholipid metabolic process, ! mRNA export from nucleus GO:0006406 18 18 0,000 0,11388001 0,14067082 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,11388001 0,1405766 ! regulation of cellular catabolic process GO:0031329 18 18 0,000 0,11388001 0,14048251 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,11388001 0,14038854 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,11388001 0,14029469 ! membrane docking GO:0022406 18 18 0,000 0,11388001 0,14020098 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,11388001 0,14010739 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,11388001 0,14001392 ! hexose transport GO:0008645 18 18 0,000 0,11388001 0,13992058 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 0,000 0,11388001 0,13982736 GO:0055092|sterol homeostasis, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 0,000 0,11388001 0,13973426 ! striated muscle contraction GO:0006941 18 18 0,000 0,11388001 0,13964129 ! negative regulation of DNA binding GO:0043392 19 18 0,000 0,11388001 0,13954845 ! ceramide metabolic process GO:0006672 18 18 0,000 0,11388001 0,13945572 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,11388001 0,13936312 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,11388001 0,13927065 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,11388001 0,13917829 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,11388001 0,13908606 ! cellular response to extracellular stimulus GO:0031668 18 18 0,000 0,11388001 0,13899395 ! BMP signaling pathway GO:0030509 18 18 0,000 0,11388001 0,13890196 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,11388001 0,13881009 ! negative regulation of catabolic process GO:0009895 18 18 0,000 0,11388001 0,13871835 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 0,000 0,11388001 0,13862673 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,11388001 0,13853522 ! male gamete generation GO:0048232 90 88 1,000 0,11674386 0,14192541 GO:0007283|spermatogenesis, ! chemotaxis GO:0006935 90 89 1,000 0,11893828 0,14449785 GO:0042330|taxis, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,11893828 0,14440266 ! DNA damage checkpoint GO:0000077 19 19 0,000 0,11982019 0,14537763 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,11982019 0,14528198 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,11982019 0,14518647 GO:0006956|complement activation, ! negative regulation of DNA metabolic process GO:0051053 19 19 0,000 0,11982019 0,14509107 ! regulation of pH GO:0006885 19 19 0,000 0,11982019 0,14499581 ! feeding behavior GO:0007631 19 19 0,000 0,11982019 0,14490067 ! peroxisome organization GO:0007031 19 19 0,000 0,11982019 0,14480565 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,11982019 0,14471076 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,11982019 0,14461599 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,11982019 0,14452135 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,11982019 0,14442683 ! eye morphogenesis GO:0048592 19 19 0,000 0,11982019 0,14433243 ! placenta development GO:0001890 19 19 0,000 0,11982019 0,14423816 ! vesicle localization GO:0051648 20 19 0,000 0,11982019 0,14414401 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,12335855 0,14830385 ! DNA replication GO:0006260 91 91 1,000 0,12335855 0,14820718 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,12572141 0,1509476 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,12572141 0,15084933 ! negative regulation of binding GO:0051100 21 20 0,000 0,12572141 0,15075118 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,12572141 0,15065316 ! nucleus organization GO:0006997 20 20 0,000 0,12572141 0,15055527 ! phagocytosis GO:0006909 21 20 0,000 0,12572141 0,15045751 ! positive regulation of gene-specific transcription GO:0043193 20 20 0,000 0,12572141 0,15035987 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,12572141 0,15026236 ! protein targeting to membrane GO:0006612 22 20 0,000 0,12572141 0,15016498 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,12572141 0,15006772 ! chromatin remodeling GO:0006338 20 20 0,000 0,12572141 0,14997059 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,12572141 0,14987359 ! lipid oxidation GO:0034440 20 20 0,000 0,12572141 0,14977671 GO:0019395|fatty acid oxidation, ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,12572141 0,14967995 ! RNA modification GO:0009451 20 20 0,000 0,12572141 0,14958332 ! single fertilization GO:0007338 21 20 0,000 0,12572141 0,14948682 ! tissue morphogenesis GO:0048729 94 93 1,000 0,12781922 0,15188319 ! regulation of response to stress GO:0080134 97 94 1,000 0,13006414 0,15445116 ! epidermis development GO:0008544 94 94 1,000 0,13006414 0,15435171 ! mRNA catabolic process GO:0006402 21 21 0,000 0,13158392 0,15605481 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,13158392 0,15595445 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,13158392 0,15585422 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,13158392 0,15575412 ! Notch signaling pathway GO:0007219 22 21 0,000 0,13158392 0,15565415 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,13158392 0,15555431 ! ear morphogenesis GO:0042471 21 21 0,000 0,13158392 0,1554546 ! organic anion transport GO:0015711 21 21 0,000 0,13158392 0,15535501 ! cholesterol transport GO:0030301 21 21 0,000 0,13158392 0,15525555 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,13158392 0,15515622 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,13158392 0,15505701 GO:0032313|regulation of Rab GTPase activity, ! DNA integrity checkpoint GO:0031570 21 21 0,000 0,13158392 0,15495794 ! regulation of protein import into nucleus GO:0042306 21 21 0,000 0,13158392 0,15485898 ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,13158392 0,15476016 ! regulation of proteolysis GO:0030162 21 21 0,000 0,13158392 0,15466146 ! negative regulation of hydrolase activity GO:0051346 21 21 0,000 0,13158392 0,15456289 ! cellular response to insulin stimulus GO:0032869 23 21 0,000 0,13158392 0,15446444 ! negative regulation of protein transport GO:0051224 21 21 0,000 0,13158392 0,15436612 ! RNA export from nucleus GO:0006405 22 22 0,000 0,13740797 0,16109598 ! positive regulation of DNA metabolic process GO:0051054 23 22 0,000 0,13740797 0,16099357 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,13740797 0,16089129 ! regulation of ion transport GO:0043269 22 22 0,000 0,13740797 0,16078914 ! odontogenesis GO:0042476 22 22 0,000 0,13740797 0,16068711 ! hormone-mediated signaling GO:0009755 22 22 0,000 0,13740797 0,16058522 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,13740797 0,16048345 ! maintenance of protein location in cell GO:0032507 23 22 0,000 0,13740797 0,16038182 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,13740797 0,16028031 ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,13740797 0,16017893 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,13740797 0,16007768 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,13740797 0,15997656 ! detection of external stimulus GO:0009581 23 22 0,000 0,13740797 0,15987556 ! neuron migration GO:0001764 22 22 0,000 0,13740797 0,15977469 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,13740797 0,15967395 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,13740797 0,15957334 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,13740797 0,15947285 ! aerobic respiration GO:0009060 22 22 0,000 0,13740797 0,15937249 ! cytokine production GO:0001816 22 22 0,000 0,13740797 0,15927226 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,13740797 0,15917215 ! anti-apoptosis GO:0006916 100 99 1,000 0,14142578 0,16372344 ! ectoderm development GO:0007398 99 99 1,000 0,14142578 0,16362066 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,1431938 0,16556222 ! viral infectious cycle GO:0019058 23 23 0,000 0,1431938 0,16545842 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,1431938 0,16535475 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,1431938 0,16525121 ! mitotic cell cycle checkpoint GO:0007093 24 23 0,000 0,1431938 0,16514779 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,1431938 0,16504451 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,1431938 0,16494136 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,1431938 0,16483834 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,1431938 0,16473544 ! lipid homeostasis GO:0055088 23 23 0,000 0,1431938 0,16463267 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,1431938 0,16453003 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,1431938 0,16442752 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 1,000 0,14372402 0,16493361 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,14894166 0,17081486 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,14894166 0,17070863 ! glucose homeostasis GO:0042593 24 24 0,000 0,14894166 0,17060254 GO:0033500|carbohydrate homeostasis, ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,14894166 0,17049657 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,14894166 0,17039074 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,14894166 0,17028504 ! fertilization GO:0009566 25 24 0,000 0,14894166 0,17017947 ! maintenance of protein location GO:0045185 25 24 0,000 0,14894166 0,17007403 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,14894166 0,16996872 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,1546518 0,17637578 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,1546518 0,17626671 ! regulation of gene-specific transcription GO:0032583 25 25 0,000 0,1546518 0,17615776 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,1546518 0,17604896 ! cellular component disassembly GO:0022411 26 25 0,000 0,1546518 0,17594029 ! endosome transport GO:0016197 25 25 0,000 0,1546518 0,17583175 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,1546518 0,17572334 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,1546518 0,17561507 ! excretion GO:0007588 25 25 0,000 0,1546518 0,17550694 ! gastrulation GO:0007369 25 25 0,000 0,1546518 0,17539893 ! heart morphogenesis GO:0003007 25 25 0,000 0,1546518 0,17529106 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,1546518 0,17518332 ! regulation of endocytosis GO:0030100 25 25 0,000 0,1546518 0,17507571 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,1546518 0,17496824 ! glycolysis GO:0006096 26 26 0,000 0,16032445 0,18127482 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,16032445 0,18116368 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 0,000 0,16032445 0,18105267 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,16032445 0,1809418 ! induction of apoptosis by intracellular signals GO:0008629 26 26 0,000 0,16032445 0,18083106 ! cellular defense response GO:0006968 26 26 0,000 0,16032445 0,18072046 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,16032445 0,18061 ! double-strand break repair GO:0006302 27 26 0,000 0,16032445 0,18049967 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,16032445 0,18038947 GO:0035150|regulation of tube size, ! response to insulin stimulus GO:0032868 28 26 0,000 0,16032445 0,18027941 ! maintenance of location in cell GO:0051651 27 26 0,000 0,16032445 0,18016949 ! chloride transport GO:0006821 27 27 0,000 0,16595985 0,18638879 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,16595985 0,18627528 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,16595985 0,18616191 ! cAMP-mediated signaling GO:0019933 27 27 0,000 0,16595985 0,18604867 ! peptide metabolic process GO:0006518 29 27 0,000 0,16595985 0,18593557 ! activation of caspase activity GO:0006919 27 27 0,000 0,16595985 0,18582261 ! inner ear development GO:0048839 27 27 0,000 0,16595985 0,18570978 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,16595985 0,18559709 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,16595985 0,18548454 ! cell growth GO:0016049 27 27 0,000 0,16595985 0,18537213 ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,17155826 0,19150931 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,17155826 0,19139338 ! carbohydrate transport GO:0008643 28 28 0,000 0,17155826 0,1912776 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,17155826 0,19116195 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,17155826 0,19104644 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,17155826 0,19093108 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,17155826 0,19081585 ! cartilage development GO:0051216 29 28 0,000 0,17155826 0,19070076 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,17711989 0,19676429 ! viral reproductive process GO:0022415 29 29 0,000 0,17711989 0,19664576 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,17711989 0,19652737 ! antigen processing and presentation GO:0019882 29 29 0,000 0,17711989 0,19640912 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,17711989 0,19629101 ! tRNA processing GO:0008033 29 29 0,000 0,17711989 0,19617305 ! adult behavior GO:0030534 30 29 0,000 0,17711989 0,19605523 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,17711989 0,19593755 ! transition metal ion transport GO:0000041 31 30 0,000 0,18264499 0,20192845 ! RNA catabolic process GO:0006401 30 30 0,000 0,18264499 0,20180739 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,18264499 0,20168647 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,18264499 0,2015657 GO:0043280|positive regulation of caspase activity, ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,18264499 0,20144508 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,18264499 0,2013246 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,18264499 0,20120426 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,18264499 0,20108406 GO:0019724|B cell mediated immunity, ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,18264499 0,20096401 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,18264499 0,20084411 ! regulation of translational initiation GO:0006446 31 31 0,000 0,1881338 0,20675647 ! membrane fusion GO:0006944 31 31 0,000 0,1881338 0,20663325 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,1881338 0,20651018 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,1881338 0,20638726 ! ion transmembrane transport GO:0034220 31 31 0,000 0,1881338 0,20626448 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,1881338 0,20614185 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,1881338 0,20601937 ! regulation of DNA replication GO:0006275 32 31 0,000 0,1881338 0,20589703 ! regulation of heart contraction GO:0008016 31 31 0,000 0,1881338 0,20577483 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,1881338 0,20565279 ! camera-type eye development GO:0043010 31 31 0,000 0,1881338 0,20553088 ! extracellular matrix organization GO:0030198 31 31 0,000 0,1881338 0,20540912 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,1881338 0,2052875 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,1881338 0,20516603 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,1881338 0,2050447 ! cell redox homeostasis GO:0045454 32 32 0,000 0,19358655 0,21086289 ! glucose catabolic process GO:0006007 32 32 0,000 0,19358655 0,21073834 ! lipid modification GO:0030258 32 32 0,000 0,19358655 0,21061393 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,19358655 0,21048968 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,19358655 0,21036557 ! cell maturation GO:0048469 32 32 0,000 0,19358655 0,2102416 ! nuclear export GO:0051168 32 32 0,000 0,19358655 0,21011779 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,19358655 0,20999412 ! maintenance of location GO:0051235 33 32 0,000 0,19358655 0,20987059 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,19900346 0,21561633 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,19900346 0,21548964 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,19900346 0,21536311 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,19900346 0,21523672 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,19900346 0,21511048 ! regulation of protein catabolic process GO:0042176 35 34 0,000 0,20438477 0,22079785 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,20438477 0,2206685 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,20438477 0,2205393 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,20438477 0,22041026 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,20438477 0,22028136 ! viral reproduction GO:0016032 34 34 0,000 0,20438477 0,22015262 ! detection of stimulus GO:0051606 36 34 0,000 0,20438477 0,22002403 ! mesoderm development GO:0007498 35 35 0,000 0,20973071 0,22564723 ! inorganic anion transport GO:0015698 35 35 0,000 0,20973071 0,22551558 ! hydrogen transport GO:0006818 36 36 0,000 0,2150415 0,23109125 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,2150415 0,23095658 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,2150415 0,23082207 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,2150415 0,23068771 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,2150415 0,23055351 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,2150415 0,23041947 ! activation of immune response GO:0002253 36 36 0,000 0,2150415 0,23028558 ! regulation of adenylate cyclase activity GO:0045761 37 37 0,000 0,22031738 0,23579845 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! negative regulation of protein kinase activity GO:0006469 37 37 0,000 0,22031738 0,2356616 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,22031738 0,2355249 ! eye development GO:0001654 37 37 0,000 0,22031738 0,23538836 ! DNA damage response, signal transduction GO:0042770 37 37 0,000 0,22031738 0,23525199 ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,22031738 0,23511577 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,22031738 0,2349797 ! neurotransmitter transport GO:0006836 40 38 0,000 0,22555856 0,24043055 ! exocytosis GO:0006887 40 38 0,000 0,22555856 0,24029158 ! negative regulation of kinase activity GO:0033673 38 38 0,000 0,22555856 0,24015276 ! hexose catabolic process GO:0019320 38 38 0,000 0,22555856 0,2400141 ! RNA elongation GO:0006354 38 38 0,000 0,22555856 0,23987561 ! regulation of neurological system process GO:0031644 38 38 0,000 0,22555856 0,23973727 ! regulation of cAMP biosynthetic process GO:0030817 39 39 0,000 0,23076527 0,24512991 ! activation of MAPK activity GO:0000187 39 39 0,000 0,23076527 0,2449887 ! response to unfolded protein GO:0006986 39 39 0,000 0,23076527 0,24484766 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,23076527 0,24470678 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,23076527 0,24456607 ! nucleotide-excision repair GO:0006289 40 39 0,000 0,23076527 0,24442551 ! developmental maturation GO:0021700 39 39 0,000 0,23076527 0,24428512 ! protein oligomerization GO:0051259 39 39 0,000 0,23076527 0,24414489 ! regulation of cAMP metabolic process GO:0030814 40 40 0,000 0,23593773 0,24947403 ! DNA catabolic process GO:0006308 41 40 0,000 0,23593773 0,24933098 ! negative regulation of transferase activity GO:0051348 40 40 0,000 0,23593773 0,2491881 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,23593773 0,24904538 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 0,000 0,24107616 0,25432362 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cell cycle checkpoint GO:0000075 42 41 0,000 0,24107616 0,25417812 ! amine catabolic process GO:0009310 42 41 0,000 0,24107616 0,2540328 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,24107616 0,25388764 ! regulation of caspase activity GO:0043281 41 41 0,000 0,24107616 0,25374264 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,24107616 0,25359781 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,24107616 0,25345314 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,24107616 0,25330864 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 0,000 0,24618078 0,25852489 ! regulation of endopeptidase activity GO:0052548 42 42 0,000 0,24618078 0,25837766 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,24618078 0,25823061 ! forebrain development GO:0030900 43 42 0,000 0,24618078 0,25808372 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 0,000 0,25125181 0,26325019 ! alcohol catabolic process GO:0046164 43 43 0,000 0,25125181 0,26310061 ! regulation of nucleotide metabolic process GO:0006140 43 43 0,000 0,25125181 0,26295121 ! vitamin metabolic process GO:0006766 44 44 0,000 0,25628946 0,26807121 ! amine biosynthetic process GO:0009309 46 45 0,000 0,26129395 0,27315073 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,26129395 0,27299589 ! protein processing GO:0016485 45 45 0,000 0,26129395 0,27284121 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 0,000 0,26626549 0,27787502 ! regulation of peptidase activity GO:0052547 46 46 0,000 0,26626549 0,27771777 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,26626549 0,27756069 ! cellular response to hormone stimulus GO:0032870 48 46 0,000 0,26626549 0,27740378 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,27120429 0,28238955 ! regulation of blood pressure GO:0008217 48 47 0,000 0,27120429 0,2822301 ! regulation of catabolic process GO:0009894 48 47 0,000 0,27120429 0,28207083 ! calcium ion transport GO:0006816 48 48 0,000 0,27611057 0,28701172 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,27611057 0,28684993 ! DNA recombination GO:0006310 48 48 0,000 0,27611057 0,28668833 ! divalent metal ion transport GO:0070838 49 49 0,000 0,28098453 0,29158474 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,28098453 0,29142065 ! regulation of DNA metabolic process GO:0051052 51 50 0,000 0,28582639 0,29627561 ! chromatin assembly GO:0031497 50 50 0,000 0,28582639 0,29610907 GO:0006334|nucleosome assembly, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 0,000 0,28582639 0,29594271 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,28582639 0,29577655 ! transcription initiation GO:0006352 50 50 0,000 0,28582639 0,29561057 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,29063634 0,30041659 ! positive regulation of immune response GO:0050778 51 51 0,000 0,29063634 0,30024819 ! rRNA metabolic process GO:0016072 51 51 0,000 0,29063634 0,30007999 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,29063634 0,29991197 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,29063634 0,29974414 ! protein maturation GO:0051604 51 51 0,000 0,29063634 0,2995765 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,2954146 0,30433153 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 0,000 0,2954146 0,30416151 ! sodium ion transport GO:0006814 53 53 0,000 0,30016137 0,30887627 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,30016137 0,30870391 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,30016137 0,30853173 ! sulfur metabolic process GO:0006790 55 54 0,000 0,30487685 0,31320403 ! nucleosome organization GO:0034728 55 55 0,000 0,30956124 0,3178392 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,30956124 0,31766223 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! in utero embryonic development GO:0001701 55 55 0,000 0,30956124 0,31748546 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,31421475 0,32207885 ! ATP metabolic process GO:0046034 57 57 0,000 0,31883757 0,32663571 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,31883757 0,32645424 ! innate immune response GO:0045087 58 58 0,000 0,3234299 0,3309724 ! sterol metabolic process GO:0016125 59 59 0,000 0,32799193 0,33545457 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,32799193 0,33526852 ! potassium ion transport GO:0006813 60 60 0,000 0,33252388 0,33971259 ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,33702591 0,3441212 GO:0016054|organic acid catabolic process, ! lipid transport GO:0006869 62 62 0,000 0,34149824 0,34849461 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,34149824 0,34830175 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,34149824 0,3481091 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,34149824 0,34791667 ! glucose metabolic process GO:0006006 63 63 0,000 0,34594105 0,35224827 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,34594105 0,35205376 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,34594105 0,35185947 ! anion transport GO:0006820 65 65 0,000 0,35473888 0,3606088 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,35909427 0,36483503 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,35909427 0,36463402 ! DNA packaging GO:0006323 66 66 0,000 0,35909427 0,36443323 ! muscle contraction GO:0006936 67 67 0,000 0,36342091 0,3686212 ! negative regulation of cell differentiation GO:0045596 68 67 0,000 0,36342091 0,36841844 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,36342091 0,3682159 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,36771896 0,37236596 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,36771896 0,37216147 ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,37623007 0,38056642 GO:0016053|organic acid biosynthetic process, ! translational elongation GO:0006414 71 71 0,000 0,38044349 0,38461731 ! ribosome biogenesis GO:0042254 71 71 0,000 0,38044349 0,38440645 ! muscle system process GO:0003012 72 72 0,000 0,38462907 0,38842267 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,39291741 0,39657546 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,39702052 0,40049744 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,39702052 0,40027835 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,41713259 0,42032552 ! MAPKKK cascade GO:0000165 82 81 0,000 0,42107552 0,42406677 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,42888325 0,43169407 ! ncRNA processing GO:0034470 83 83 0,000 0,42888325 0,43145843 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,43274839 0,43510927 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,43658794 0,43873041 ! hexose metabolic process GO:0019318 87 86 0,000 0,44040207 0,44232207 ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,44795468 0,44966257 ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,45540755 0,456895 ! visual perception GO:0007601 93 92 0,000 0,46276197 0,46402084 GO:0050953|sensory perception of light stimulus, ! fatty acid metabolic process GO:0006631 93 92 0,000 0,46276197 0,46376852 ! cofactor metabolic process GO:0051186 95 94 0,000 0,47001919 0,47078553 ! endocytosis GO:0006897 99 98 0,000 0,48424709 0,48477316 GO:0010324|membrane invagination, ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,48424709 0,48450998 ! regulation of system process GO:0044057 98 98 0,000 0,48424709 0,48424709