pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6729-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 13 6 3,000 2,318E-09 5,664E-06 ! establishment of nucleus localization GO:0040023 18 8 3,000 1,076E-08 1,314E-05 ! nucleus localization GO:0051647 22 11 3,000 5,03E-08 4,096E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 5,000 1,842E-07 1,125E-04 ! negative regulation of kinase activity GO:0033673 145 70 5,000 2,009E-07 9,814E-05 ! negative regulation of transferase activity GO:0051348 155 74 5,000 2,805E-07 1,142E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 5,861E-07 2,046E-04 ! L-serine biosynthetic process GO:0006564 7 6 2,000 8,84E-07 2,699E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 8,84E-07 2,399E-04 GO:0031272|regulation of pseudopodium assembly, ! inactivation of MAPK activity GO:0000188 45 22 3,000 1,082E-06 2,642E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 1,543E-06 3,427E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 1,563E-06 3,181E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 2,186E-06 4,108E-04 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 2,186E-06 3,815E-04 GO:0045936|negative regulation of phosphate metabolic process, ! establishment of organelle localization GO:0051656 122 59 4,000 2,308E-06 3,758E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 2,462E-06 3,759E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,462E-06 3,538E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 2,559E-06 3,474E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 2,978E-06 3,829E-04 ! induction of positive chemotaxis GO:0050930 17 9 2,000 3,684E-06 4,5E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 3,684E-06 4,285E-04 ! macrophage differentiation GO:0030225 15 9 2,000 3,684E-06 4,091E-04 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 5,249E-06 5,575E-04 ! negative regulation of MAP kinase activity GO:0043407 78 34 3,000 6,633E-06 6,752E-04 ! organelle localization GO:0051640 155 74 4,000 7,114E-06 6,951E-04 ! L-serine metabolic process GO:0006563 21 11 2,000 7,198E-06 6,763E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 7,198E-06 6,513E-04 ! negative regulation of glucose import GO:0046325 18 11 2,000 7,198E-06 6,28E-04 GO:0010829|negative regulation of glucose transport, ! regulation of positive chemotaxis GO:0050926 22 12 2,000 9,572E-06 8,064E-04 GO:0050927|positive regulation of positive chemotaxis, ! regulation of cell projection assembly GO:0060491 33 12 2,000 9,572E-06 7,795E-04 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 1,044E-05 8,229E-04 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 1,404E-05 1,072E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 3,000 1,421E-05 1,052E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 1,575E-05 1,132E-03 ! serine family amino acid biosynthetic process GO:0009070 19 14 2,000 1,575E-05 1,1E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 1,964E-05 1,333E-03 ! actin cytoskeleton reorganization GO:0031532 38 15 2,000 1,964E-05 1,297E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 2,174E-05 1,398E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 2,258E-05 1,414E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 2,461E-05 1,503E-03 ! negative regulation of cell cycle process GO:0010948 35 17 2,000 2,92E-05 1,74E-03 ! filopodium assembly GO:0046847 42 17 2,000 2,92E-05 1,699E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 2,92E-05 1,659E-03 ! negative regulation of protein catabolic process GO:0042177 42 18 2,000 3,495E-05 1,941E-03 ! microspike assembly GO:0030035 46 18 2,000 3,495E-05 1,897E-03 ! regulation of glucose import GO:0046324 30 20 2,000 4,857E-05 2,58E-03 GO:0010827|regulation of glucose transport, ! positive regulation of inflammatory response GO:0050729 41 21 2,000 5,652E-05 2,938E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 6,528E-05 3,322E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 2,000 6,528E-05 3,254E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 7,487E-05 3,658E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 8,366E-05 4,007E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 8,366E-05 3,93E-03 ! negative regulation of catabolic process GO:0009895 52 24 2,000 8,534E-05 3,934E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 9,673E-05 4,376E-03 ! regulation of behavior GO:0050795 48 25 2,000 9,673E-05 4,297E-03 ! interaction with host GO:0051701 66 25 2,000 9,673E-05 4,22E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 1,123E-04 4,812E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 1,224E-04 5,154E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 1,224E-04 5,067E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 1,258E-04 5,121E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 1,258E-04 5,037E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 1,258E-04 4,956E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 1,258E-04 4,877E-03 ! valine metabolic process GO:0006573 12 5 1,000 1,258E-04 4,801E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 1,258E-04 4,727E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 1,258E-04 4,656E-03 GO:0051930|regulation of sensory perception of pain, ! negative regulation of protein modification process GO:0031400 66 28 2,000 1,367E-04 4,984E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 3,000 1,474E-04 5,295E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 1,685E-04 5,967E-03 ! regulation of catabolic process GO:0009894 173 77 3,000 1,719E-04 6E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 1,000 1,882E-04 6,476E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! early endosome to late endosome transport GO:0045022 16 6 1,000 1,882E-04 6,386E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 1,882E-04 6,299E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 1,882E-04 6,214E-03 GO:0045686|negative regulation of glial cell differentiation, ! positive regulation of phosphorylation GO:0042327 149 81 3,000 2,09E-04 6,809E-03 ! leukocyte chemotaxis GO:0030595 55 33 2,000 2,247E-04 7,223E-03 GO:0060326|cell chemotaxis, ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 2,296E-04 7,285E-03 GO:0045937|positive regulation of phosphate metabolic process, ! serine family amino acid metabolic process GO:0009069 56 34 2,000 2,458E-04 7,699E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 2,458E-04 7,602E-03 ! negative regulation of transport GO:0051051 164 85 3,000 2,516E-04 7,684E-03 ! sleep GO:0030431 16 7 1,000 2,629E-04 7,929E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 2,629E-04 7,832E-03 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 2,629E-04 7,738E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 2,629E-04 7,646E-03 ! male sex determination GO:0030238 15 7 1,000 2,629E-04 7,556E-03 ! spindle checkpoint GO:0031577 16 7 1,000 2,629E-04 7,468E-03 ! negative regulation of nuclear division GO:0051784 15 7 1,000 2,629E-04 7,382E-03 GO:0045839|negative regulation of mitosis, ! mitotic sister chromatid segregation GO:0000070 63 36 2,000 2,918E-04 8,1E-03 ! positive regulation of protein modification process GO:0031401 156 90 3,000 3,132E-04 8,597E-03 ! sister chromatid segregation GO:0000819 65 37 2,000 3,167E-04 8,597E-03 ! succinate metabolic process GO:0006105 17 8 1,000 3,497E-04 9,388E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 3,497E-04 9,286E-03 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 3,497E-04 9,186E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 3,497E-04 9,089E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 3,497E-04 8,993E-03 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 1,000 3,497E-04 8,899E-03 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 4,3E-04 0,01082963 ! leukocyte differentiation GO:0002521 232 98 3,000 4,331E-04 0,01079709 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 4,331E-04 0,01068803 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 4,486E-04 0,01095846 ! Golgi to endosome transport GO:0006895 25 9 1,000 4,486E-04 0,01084996 ! regulation of glycolysis GO:0006110 20 9 1,000 4,486E-04 0,01074359 ! middle ear morphogenesis GO:0042474 14 9 1,000 4,486E-04 0,01063928 ! receptor clustering GO:0043113 20 9 1,000 4,486E-04 0,01053698 ! response to amine stimulus GO:0014075 13 9 1,000 4,486E-04 0,01043663 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of telomere maintenance GO:0032204 17 9 1,000 4,486E-04 0,01033817 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 5,301E-04 0,01210238 ! regulation of developmental growth GO:0048638 16 10 1,000 5,594E-04 0,01265372 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 5,594E-04 0,01253763 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 5,594E-04 0,01242365 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 5,594E-04 0,01231173 ! phosphagen metabolic process GO:0006599 17 10 1,000 5,594E-04 0,0122018 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 22 10 1,000 5,594E-04 0,01209382 ! protein heterooligomerization GO:0051291 17 10 1,000 5,594E-04 0,01198773 ! regulation of gliogenesis GO:0014013 23 10 1,000 5,594E-04 0,01188349 GO:0045685|regulation of glial cell differentiation, ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 5,594E-04 0,01178105 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of gene-specific transcription GO:0032583 102 46 2,000 6,044E-04 0,01262002 ! leukocyte migration GO:0050900 75 46 2,000 6,044E-04 0,01251307 ! pigmentation GO:0043473 103 46 2,000 6,044E-04 0,01240792 ! negative regulation of muscle development GO:0048635 27 11 1,000 6,821E-04 0,01388653 ! detection of mechanical stimulus GO:0050982 22 11 1,000 6,821E-04 0,01377176 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 6,821E-04 0,01365888 ! adult heart development GO:0007512 16 11 1,000 6,821E-04 0,01354783 ! neuroblast proliferation GO:0007405 25 11 1,000 6,821E-04 0,01343858 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 1,000 6,821E-04 0,01333107 ! regulation of embryonic development GO:0045995 35 11 1,000 6,821E-04 0,01322526 ! positive regulation of defense response GO:0031349 88 48 2,000 6,851E-04 0,01317818 ! endosome transport GO:0016197 127 48 2,000 6,851E-04 0,01307523 ! regulation of inflammatory response GO:0050727 84 48 2,000 6,851E-04 0,01297387 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 7,279E-04 0,01367805 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 7,723E-04 0,01440253 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 8,166E-04 0,01511351 ! virus-host interaction GO:0019048 30 12 1,000 8,166E-04 0,01499987 ! regulation of B cell proliferation GO:0030888 22 12 1,000 8,166E-04 0,01488793 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 8,166E-04 0,01477765 ! hippocampus development GO:0021766 29 12 1,000 8,166E-04 0,01466899 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 8,166E-04 0,01456192 ! entry into host cell GO:0030260 34 12 1,000 8,166E-04 0,0144564 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 8,166E-04 0,0143524 ! peptidyl-lysine modification GO:0018205 21 12 1,000 8,166E-04 0,01424988 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 8,166E-04 0,01414882 GO:0042130|negative regulation of T cell proliferation, ! regulation of cell projection organization GO:0031344 135 51 2,000 8,184E-04 0,01408059 ! cellular amino acid biosynthetic process GO:0008652 80 52 2,000 8,663E-04 0,01479964 ! positive regulation of growth GO:0045927 96 53 2,000 9,159E-04 0,01553822 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 9,159E-04 0,01543106 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 2,000 9,159E-04 0,01532537 ! indolalkylamine metabolic process GO:0006586 19 13 1,000 9,628E-04 0,01600132 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 9,628E-04 0,01589321 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 9,628E-04 0,01578654 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 9,628E-04 0,0156813 ! regulation of muscle contraction GO:0006937 94 54 2,000 9,672E-04 0,01564881 ! regulation of cell shape GO:0008360 142 54 2,000 9,672E-04 0,01554586 ! epithelial tube morphogenesis GO:0060562 114 54 2,000 9,672E-04 0,01544425 ! regulation of protein catabolic process GO:0042176 126 56 2,000 1,075E-03 0,01705892 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,121E-03 0,0176633 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 1,121E-03 0,01755008 GO:0060675|ureteric bud morphogenesis, ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 1,132E-03 0,01761672 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,29E-03 0,01994703 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 1,000 1,29E-03 0,01982158 ! dopamine metabolic process GO:0042417 35 15 1,000 1,29E-03 0,0196977 ! lipid modification GO:0030258 112 60 2,000 1,314E-03 0,01993518 ! DNA catabolic process GO:0006308 94 60 2,000 1,314E-03 0,01981212 ! regulation of heart contraction GO:0008016 123 61 2,000 1,378E-03 0,02065535 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 1,378E-03 0,0205294 ! viral reproductive process GO:0022415 132 62 2,000 1,444E-03 0,02138692 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 1,471E-03 0,02164729 ! startle response GO:0001964 28 16 1,000 1,471E-03 0,02151766 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 1,471E-03 0,02138958 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 1,471E-03 0,02126301 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of protein complex assembly GO:0043254 132 63 2,000 1,513E-03 0,02173928 ! regulation of mitosis GO:0007088 112 63 2,000 1,513E-03 0,02161215 GO:0051783|regulation of nuclear division, ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 1,663E-03 0,02362246 ! signal complex assembly GO:0007172 47 17 1,000 1,663E-03 0,02348592 ! regulation of survival gene product expression GO:0045884 38 17 1,000 1,663E-03 0,02335094 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 1,663E-03 0,02321751 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 1,663E-03 0,02308559 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 1,73E-03 0,02387343 ! activation of MAPK activity GO:0000187 124 67 2,000 1,806E-03 0,0247877 ! chromosome segregation GO:0007059 127 67 2,000 1,806E-03 0,02464922 ! fatty acid biosynthetic process GO:0006633 139 67 2,000 1,806E-03 0,02451228 ! myeloid cell differentiation GO:0030099 126 67 2,000 1,806E-03 0,02437685 ! limbic system development GO:0021761 40 18 1,000 1,867E-03 0,02505645 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 1,867E-03 0,02491953 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 1,867E-03 0,0247841 ! viral reproduction GO:0016032 142 68 2,000 1,885E-03 0,02488591 ! cell projection assembly GO:0030031 138 68 2,000 1,885E-03 0,02475211 ! memory GO:0007613 34 19 1,000 2,081E-03 0,02719186 ! regulation of postsynaptic membrane potential GO:0060078 38 19 1,000 2,081E-03 0,02704723 ! pigmentation during development GO:0048066 42 19 1,000 2,081E-03 0,02690412 ! neuromuscular junction development GO:0007528 43 19 1,000 2,081E-03 0,02676252 ! visual learning GO:0008542 38 19 1,000 2,081E-03 0,0266224 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 2,307E-03 0,02935771 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 2,307E-03 0,02920559 ! protein amino acid acetylation GO:0006473 41 20 1,000 2,307E-03 0,02905505 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 2,307E-03 0,02890605 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 2,307E-03 0,02875857 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 2,307E-03 0,02861259 ! response to alkaloid GO:0043279 38 20 1,000 2,307E-03 0,02846808 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 2,307E-03 0,02832502 ! fatty acid beta-oxidation GO:0006635 36 20 1,000 2,307E-03 0,0281834 ! negative regulation of T cell activation GO:0050868 41 20 1,000 2,307E-03 0,02804318 ! regulation of transcription factor activity GO:0051090 137 75 2,000 2,494E-03 0,03015654 GO:0090046|regulation of transcription regulator activity, ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 2,544E-03 0,03061813 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 2,544E-03 0,03046804 ! lipid phosphorylation GO:0046834 43 21 1,000 2,544E-03 0,03031941 ! prostaglandin metabolic process GO:0006693 43 21 1,000 2,544E-03 0,03017223 GO:0006692|prostanoid metabolic process, ! learning or memory GO:0007611 161 76 2,000 2,589E-03 0,03055824 ! hindlimb morphogenesis GO:0035137 47 22 1,000 2,792E-03 0,03279366 ! glutamate signaling pathway GO:0007215 48 22 1,000 2,792E-03 0,03263675 ! apoptotic nuclear changes GO:0030262 34 22 1,000 2,792E-03 0,03248134 ! ureteric bud development GO:0001657 50 22 1,000 2,792E-03 0,0323274 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 2,792E-03 0,03217491 ! positive regulation of B cell activation GO:0050871 42 22 1,000 2,792E-03 0,03202385 ! protein stabilization GO:0050821 41 22 1,000 2,792E-03 0,03187421 ! negative regulation of organelle organization GO:0010639 181 80 2,000 2,995E-03 0,03403039 ! positive regulation of DNA replication GO:0045740 44 23 1,000 3,051E-03 0,03450596 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 3,051E-03 0,03434695 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 1,000 3,051E-03 0,03418939 ! visual behavior GO:0007632 46 23 1,000 3,051E-03 0,03403327 ! response to ethanol GO:0045471 47 23 1,000 3,051E-03 0,03387858 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 3,051E-03 0,03372528 ! acetyl-CoA catabolic process GO:0046356 37 23 1,000 3,051E-03 0,03357337 GO:0006099|tricarboxylic acid cycle, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 3,32E-03 0,03637625 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 3,32E-03 0,03621386 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 3,32E-03 0,03605291 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 3,32E-03 0,03589338 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 3,32E-03 0,03573526 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 3,32E-03 0,03557853 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 3,32E-03 0,03542316 ! sex determination GO:0007530 48 24 1,000 3,32E-03 0,03526915 ! membrane depolarization GO:0051899 45 24 1,000 3,32E-03 0,03511647 ! pallium development GO:0021543 56 24 1,000 3,32E-03 0,03496511 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 3,601E-03 0,03775424 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 3,601E-03 0,0375929 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 3,601E-03 0,03743293 ! receptor metabolic process GO:0043112 53 25 1,000 3,601E-03 0,03727432 ! protein tetramerization GO:0051262 57 25 1,000 3,601E-03 0,03711704 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 3,892E-03 0,03994789 ! myelination GO:0042552 50 26 1,000 3,892E-03 0,03978074 ! initiation of viral infection GO:0019059 60 26 1,000 3,892E-03 0,03961499 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 3,892E-03 0,03945061 ! coenzyme catabolic process GO:0009109 42 26 1,000 3,892E-03 0,03928759 ! negative regulation of cell development GO:0010721 83 26 1,000 3,892E-03 0,03912592 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 3,892E-03 0,03896556 GO:0045840|positive regulation of mitosis, ! neural tube closure GO:0001843 58 26 1,000 3,892E-03 0,03880652 GO:0060606|tube closure, ! cellular respiration GO:0045333 143 88 2,000 3,918E-03 0,03891088 ! amine biosynthetic process GO:0009309 146 88 2,000 3,918E-03 0,03875335 ! regulation of DNA binding GO:0051101 167 89 2,000 4,044E-03 0,03984037 ! tube morphogenesis GO:0035239 194 89 2,000 4,044E-03 0,03968037 ! regulation of cell cycle process GO:0010564 161 90 2,000 4,173E-03 0,04077893 ! acetyl-CoA metabolic process GO:0006084 41 27 1,000 4,193E-03 0,0408139 ! tube lumen formation GO:0035148 59 27 1,000 4,193E-03 0,04065194 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 4,193E-03 0,04049126 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 4,505E-03 0,04333316 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 4,505E-03 0,04316322 ! protein amino acid acylation GO:0043543 59 28 1,000 4,505E-03 0,04299462 ! lipid oxidation GO:0034440 48 28 1,000 4,505E-03 0,04282732 GO:0019395|fatty acid oxidation, ! regulation of cell morphogenesis GO:0022604 243 93 2,000 4,574E-03 0,04330987 ! regulation of membrane potential GO:0042391 179 94 2,000 4,712E-03 0,04444998 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 4,828E-03 0,0453631 ! catechol metabolic process GO:0009712 55 29 1,000 4,828E-03 0,0451893 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! primary neural tube formation GO:0014020 61 29 1,000 4,828E-03 0,04501682 ! somitogenesis GO:0001756 52 29 1,000 4,828E-03 0,04484565 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 4,828E-03 0,04467578 ! regulation of defense response GO:0031347 171 95 2,000 4,854E-03 0,0447445 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 5,143E-03 0,04723822 ! transcription initiation GO:0006352 171 97 2,000 5,143E-03 0,0470613 ! phenol metabolic process GO:0018958 56 30 1,000 5,161E-03 0,04704274 ! acute-phase response GO:0006953 50 30 1,000 5,161E-03 0,04686786 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 5,161E-03 0,04669428 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 5,161E-03 0,04652198 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 1,000 5,161E-03 0,04635094 ! iron ion homeostasis GO:0055072 60 31 1,000 5,504E-03 0,04925121 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 5,504E-03 0,04907146 ! ensheathment of neurons GO:0007272 64 31 1,000 5,504E-03 0,04889302 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 1,000 5,504E-03 0,04871587 ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 5,504E-03 0,04854 ! fatty acid catabolic process GO:0009062 54 31 1,000 5,504E-03 0,0483654 ! skeletal muscle tissue development GO:0007519 223 100 2,000 5,597E-03 0,0490121 GO:0060538|skeletal muscle organ development, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 5,857E-03 0,05110212 ! spindle organization GO:0007051 50 32 1,000 5,857E-03 0,05092026 ! metanephros development GO:0001656 81 32 1,000 5,857E-03 0,05073969 ! response to mechanical stimulus GO:0009612 60 32 1,000 5,857E-03 0,0505604 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 5,857E-03 0,05038237 ! peripheral nervous system development GO:0007422 68 32 1,000 5,857E-03 0,05020559 ! positive regulation of catabolic process GO:0009896 72 32 1,000 5,857E-03 0,05003005 ! negative regulation of protein transport GO:0051224 74 33 1,000 6,22E-03 0,05294882 ! regulation of synaptic plasticity GO:0048167 78 35 1,000 6,977E-03 0,05918443 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 6,977E-03 0,05897964 ! telencephalon development GO:0021537 81 35 1,000 6,977E-03 0,05877626 ! regulation of muscle development GO:0048634 82 36 1,000 7,37E-03 0,06187574 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 7,37E-03 0,06166383 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 1,000 7,37E-03 0,06145338 ! negative regulation of DNA binding GO:0043392 67 36 1,000 7,37E-03 0,06124435 ! aerobic respiration GO:0009060 56 36 1,000 7,37E-03 0,06103674 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 7,773E-03 0,0641572 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! maintenance of protein location in cell GO:0032507 89 37 1,000 7,773E-03 0,06394119 ! negative regulation of cell activation GO:0050866 69 37 1,000 7,773E-03 0,06372662 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 8,186E-03 0,06688634 ! meiosis I GO:0007127 74 38 1,000 8,186E-03 0,06666338 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 8,186E-03 0,06644191 ! regulation of protein stability GO:0031647 77 38 1,000 8,186E-03 0,0662219 ! neural tube formation GO:0001841 79 38 1,000 8,186E-03 0,06600335 ! negative regulation of binding GO:0051100 71 39 1,000 8,609E-03 0,06918128 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 8,609E-03 0,06895445 ! carbohydrate homeostasis GO:0033500 59 39 1,000 8,609E-03 0,06872911 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 8,609E-03 0,06850524 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 1,000 9,041E-03 0,07170985 ! learning GO:0007612 82 40 1,000 9,041E-03 0,07147777 ! nucleus organization GO:0006997 73 40 1,000 9,041E-03 0,0712472 ! regulation of action potential in neuron GO:0019228 80 40 1,000 9,041E-03 0,07101811 ! cellular amide metabolic process GO:0043603 73 41 1,000 9,482E-03 0,07424811 ! maintenance of protein location GO:0045185 95 41 1,000 9,482E-03 0,07401089 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 9,482E-03 0,07377519 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 9,933E-03 0,07703893 ! ear morphogenesis GO:0042471 64 42 1,000 9,933E-03 0,07679514 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 9,933E-03 0,07655288 ! T cell differentiation GO:0030217 93 42 1,000 9,933E-03 0,07631215 ! regulation of T cell differentiation GO:0045580 78 42 1,000 9,933E-03 0,07607293 ! cytokinesis GO:0000910 84 42 1,000 9,933E-03 0,0758352 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01039379 0,07910286 GO:0090047|positive regulation of transcription regulator activity, ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,01039379 0,0788572 ! segmentation GO:0035282 78 43 1,000 0,01039379 0,07861306 ! neuron migration GO:0001764 85 43 1,000 0,01039379 0,07837042 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,01134242 0,08526008 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01134242 0,08499855 ! ATP synthesis coupled electron transport GO:0042773 69 45 1,000 0,01134242 0,08473861 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! maintenance of location in cell GO:0051651 101 45 1,000 0,01134242 0,08448026 ! glycolysis GO:0006096 71 46 1,000 0,01183051 0,08784783 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,01183051 0,08758162 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,01183051 0,08731702 ! neural tube development GO:0021915 91 47 1,000 0,01232769 0,0907125 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,01283389 0,09415375 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,01283389 0,09387185 ! cellular component disassembly GO:0022411 89 48 1,000 0,01283389 0,09359164 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,01283389 0,09331309 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,01283389 0,0930362 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,01283389 0,09276094 ! response to calcium ion GO:0051592 94 49 1,000 0,01334904 0,09619974 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,01334904 0,0959168 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,01334904 0,09563552 ! JNK cascade GO:0007254 106 49 1,000 0,01334904 0,09535588 ! regulation of action potential GO:0001508 102 50 1,000 0,01387307 0,09881026 ! activation of caspase activity GO:0006919 95 50 1,000 0,01387307 0,09852302 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,01387307 0,09823744 ! viral infectious cycle GO:0019058 104 51 1,000 0,01440592 0,10171576 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,01440592 0,10142263 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,01440592 0,10113118 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,01440592 0,10084141 ! positive regulation of binding GO:0051099 88 52 1,000 0,0149475 0,10433356 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,0149475 0,10403631 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,0149475 0,10374075 ! histone modification GO:0016570 104 52 1,000 0,0149475 0,10344687 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,0149475 0,10315464 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,0149475 0,10286407 ! respiratory electron transport chain GO:0022904 83 53 1,000 0,01549776 0,1063512 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,01549776 0,1060533 ! synapse organization GO:0050808 102 53 1,000 0,01549776 0,10575706 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,01605663 0,10926557 ! neuromuscular process GO:0050905 107 54 1,000 0,01605663 0,10896205 ! covalent chromatin modification GO:0016569 115 54 1,000 0,01605663 0,10866022 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,01662403 0,11218925 ! response to UV GO:0009411 120 55 1,000 0,01662403 0,11188019 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,01719991 0,11543785 ! glucose catabolic process GO:0006007 88 56 1,000 0,01719991 0,11512158 ! regulation of DNA replication GO:0006275 105 56 1,000 0,01719991 0,11480704 ! RNA elongation GO:0006354 90 56 1,000 0,01719991 0,11449422 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01773896 0,11776164 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01773896 0,1174425 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01773896 0,11712509 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01773896 0,11680939 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01773896 0,11649539 ! neuron fate determination GO:0048664 7 5 0,000 0,01773896 0,11618307 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01773896 0,11587242 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01773896 0,11556342 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01773896 0,11525607 ! polyol transport GO:0015791 12 5 0,000 0,01773896 0,11495035 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01773896 0,11464625 ! response to superoxide GO:0000303 10 5 0,000 0,01773896 0,11434376 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01773896 0,11404285 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01773896 0,11374353 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01773896 0,11344577 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01773896 0,11314956 ! female meiosis GO:0007143 10 5 0,000 0,01773896 0,1128549 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01773896 0,11256178 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01773896 0,11227016 ! hypothalamus development GO:0021854 9 5 0,000 0,01773896 0,11198006 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01773896 0,11169145 ! cobalt ion transport GO:0006824 11 5 0,000 0,01773896 0,11140433 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01773896 0,11111868 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01773896 0,11083448 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01773896 0,11055174 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01773896 0,11027044 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01773896 0,10999057 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01773896 0,10971211 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01773896 0,10943506 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01773896 0,1091594 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01773896 0,10888513 ! transposition GO:0032196 9 5 0,000 0,01773896 0,10861224 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01773896 0,10834071 ! negative chemotaxis GO:0050919 16 5 0,000 0,01773896 0,10807053 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01773896 0,1078017 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01773896 0,1075342 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01773896 0,10726803 ! behavioral response to pain GO:0048266 10 5 0,000 0,01773896 0,10700317 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01773896 0,10673961 ! Notch receptor processing GO:0007220 11 5 0,000 0,01773896 0,10647735 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01773896 0,10621638 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01773896 0,10595668 ! micturition GO:0060073 9 5 0,000 0,01773896 0,10569825 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01773896 0,10544108 ! copulation GO:0007620 9 5 0,000 0,01773896 0,10518515 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01773896 0,10493047 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01773896 0,10467701 ! bioluminescence GO:0008218 9 5 0,000 0,01773896 0,10442478 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01773896 0,10417376 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01773896 0,10392394 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01773896 0,10367532 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01773896 0,10342788 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01773896 0,10318163 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01773896 0,10293654 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01773896 0,10269261 ! grooming behavior GO:0007625 6 5 0,000 0,01773896 0,10244984 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01773896 0,10220822 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01773896 0,10196773 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01773896 0,10172836 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01773896 0,10149013 ! response to protozoan GO:0001562 13 5 0,000 0,01773896 0,101253 ! lymph vessel development GO:0001945 10 5 0,000 0,01773896 0,10101698 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01773896 0,10078205 ! endochondral ossification GO:0001958 17 5 0,000 0,01773896 0,10054822 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01773896 0,10031547 ! single strand break repair GO:0000012 8 5 0,000 0,01773896 0,1000838 ! parathyroid gland development GO:0060017 14 5 0,000 0,01773896 0,09985319 ! anagen GO:0042640 7 5 0,000 0,01773896 0,09962364 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01773896 0,09939515 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01773896 0,0991677 ! cytokine secretion GO:0050663 15 5 0,000 0,01773896 0,09894129 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01773896 0,09871591 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01773896 0,09849155 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01773896 0,09826822 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01773896 0,09804589 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01773896 0,09782457 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01773896 0,09760424 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01773896 0,09738491 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01773896 0,09716655 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01773896 0,09694918 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01773896 0,09673278 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01773896 0,09651733 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01773896 0,09630285 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01773896 0,09608932 ! microvillus organization GO:0032528 8 5 0,000 0,01773896 0,09587673 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01773896 0,09566508 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01773896 0,09545437 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01773896 0,09524458 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01773896 0,09503571 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01773896 0,09482775 ! polyol catabolic process GO:0046174 9 5 0,000 0,01773896 0,09462071 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01773896 0,09441456 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01773896 0,09420931 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01773896 0,09400495 ! muscle cell migration GO:0014812 8 5 0,000 0,01773896 0,09380148 ! mitochondrial fission GO:0000266 8 5 0,000 0,01773896 0,09359888 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01773896 0,09339716 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01773896 0,09319631 ! mRNA transcription GO:0009299 10 5 0,000 0,01773896 0,09299632 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01773896 0,09279718 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01773896 0,0925989 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01773896 0,09240146 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01773896 0,09220486 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01773896 0,09200909 ! monocyte activation GO:0042117 10 5 0,000 0,01773896 0,09181416 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01773896 0,09162005 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01773896 0,09142676 ! response to food GO:0032094 6 5 0,000 0,01773896 0,09123428 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01773896 0,09104261 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01773896 0,09085175 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01773896 0,09066168 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01773896 0,09047241 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,01773896 0,09028392 ! forebrain neuron development GO:0021884 13 5 0,000 0,01773896 0,09009622 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01773896 0,0899093 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01773896 0,08972315 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01773896 0,08953778 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01773896 0,08935316 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01773896 0,08916931 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01773896 0,08898621 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01773896 0,08880386 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01773896 0,08862226 ! lipid glycosylation GO:0030259 7 5 0,000 0,01773896 0,08844139 ! nucleobase transport GO:0015851 6 5 0,000 0,01773896 0,08826127 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01773896 0,08808188 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01773896 0,08790321 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01773896 0,08772527 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01773896 0,08754805 ! basic amino acid transport GO:0015802 12 5 0,000 0,01773896 0,08737154 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01773896 0,08719574 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01773896 0,08702065 ! actin nucleation GO:0045010 11 5 0,000 0,01773896 0,08684626 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01773896 0,08667257 ! depurination GO:0045007 5 5 0,000 0,01773896 0,08649957 ! depyrimidination GO:0045008 10 5 0,000 0,01773896 0,08632726 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01773896 0,08615563 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01773896 0,08598469 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01773896 0,08581442 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01773896 0,08564483 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01773896 0,0854759 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01773896 0,08530764 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01773896 0,08514005 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01773896 0,0849731 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01773896 0,08480682 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01773896 0,08464118 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01773896 0,08447619 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01773896 0,08431184 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01773896 0,08414812 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01773896 0,08398505 ! response to arsenic GO:0046685 11 5 0,000 0,01773896 0,0838226 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01773896 0,08366078 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01773896 0,08349958 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01773896 0,08333901 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01773896 0,08317905 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01773896 0,0830197 ! response to mercury ion GO:0046689 8 5 0,000 0,01773896 0,08286096 ! response to cadmium ion GO:0046686 7 5 0,000 0,01773896 0,08270283 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01773896 0,0825453 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01773896 0,08238837 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01773896 0,08223204 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01773896 0,08207629 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01773896 0,08192114 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01773896 0,08176657 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01773896 0,08161259 ! decidualization GO:0046697 11 5 0,000 0,01773896 0,08145918 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01773896 0,08130635 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01773896 0,08115409 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01773896 0,0810024 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01773896 0,08085127 ! embryonic cleavage GO:0040016 6 5 0,000 0,01773896 0,08070071 ! peroxisome fission GO:0016559 5 5 0,000 0,01773896 0,08055071 ! histone demethylation GO:0016577 13 5 0,000 0,01773896 0,08040127 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01773896 0,08025238 ! mitotic recombination GO:0006312 9 5 0,000 0,01773896 0,08010404 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01773896 0,07995624 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01773896 0,07980899 ! metaphase plate congression GO:0051310 7 5 0,000 0,01773896 0,07966229 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01773896 0,07951612 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01773896 0,07937048 ! enteric nervous system development GO:0048484 8 5 0,000 0,01773896 0,07922538 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01773896 0,07908081 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01773896 0,07893676 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01773896 0,07879324 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01773896 0,07865024 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01773896 0,07850776 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01773896 0,07836579 ! B cell homeostasis GO:0001782 13 5 0,000 0,01773896 0,07822434 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01773896 0,07808339 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01773896 0,07794296 ! metaphase GO:0051323 11 5 0,000 0,01773896 0,07780302 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01773896 0,07766359 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01773896 0,07752466 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01773896 0,07738622 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01773896 0,07724828 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01773896 0,07711082 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01773896 0,07697386 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01773896 0,07683738 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01773896 0,07670139 ! response to redox state GO:0051775 6 5 0,000 0,01773896 0,07656587 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01773896 0,07643083 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01773896 0,07629627 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01773896 0,07616219 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01773896 0,07602857 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01773896 0,07589542 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01773896 0,07576273 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01773896 0,07563051 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01773896 0,07549875 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01773896 0,07536745 ! striatum development GO:0021756 14 5 0,000 0,01773896 0,0752366 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01773896 0,07510621 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01773896 0,07497627 ! glial cell migration GO:0008347 10 5 0,000 0,01773896 0,07484678 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01773896 0,07471773 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01773896 0,07458913 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01773896 0,07446097 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01773896 0,07433325 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01773896 0,07420596 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01773896 0,07407912 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01773896 0,0739527 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01773896 0,07382672 ! neuroprotection GO:0043526 8 5 0,000 0,01773896 0,07370116 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01773896 0,07357603 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01773896 0,07345133 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01773896 0,07332704 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01773896 0,07320318 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01773896 0,07307974 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01773896 0,07295671 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01773896 0,07283409 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01773896 0,07271188 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01773896 0,07259009 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,01773896 0,0724687 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01773896 0,07234772 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01773896 0,07222714 ! spindle assembly GO:0051225 6 5 0,000 0,01773896 0,07210696 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01773896 0,07198718 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01773896 0,0718678 ! protein palmitoylation GO:0018345 12 5 0,000 0,01773896 0,07174881 ! drug metabolic process GO:0017144 7 5 0,000 0,01773896 0,07163022 ! stem cell division GO:0017145 11 5 0,000 0,01773896 0,07151202 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01773896 0,07139421 ! organ regeneration GO:0031100 7 5 0,000 0,01773896 0,07127678 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01773896 0,07115974 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01773896 0,07104309 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,01778419 0,07110766 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,01778419 0,07099147 ! heart morphogenesis GO:0003007 105 57 1,000 0,01778419 0,07087566 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,01778419 0,07076023 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,01778419 0,07064517 ! positive regulation of cell migration GO:0030335 137 58 1,000 0,01837681 0,07288077 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,01837681 0,07276265 ! maintenance of location GO:0051235 124 58 1,000 0,01837681 0,07264491 ! kidney development GO:0001822 133 60 1,000 0,01958681 0,07730302 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,02020405 0,07961047 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,02082937 0,08194227 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02124911 0,08345912 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02124911 0,08332516 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02124911 0,08319163 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02124911 0,08305852 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02124911 0,08292584 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02124911 0,08279358 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02124911 0,08266174 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02124911 0,08253033 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02124911 0,08239933 ! response to oxygen radical GO:0000305 11 6 0,000 0,02124911 0,08226874 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02124911 0,08213857 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02124911 0,08200881 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02124911 0,08187946 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02124911 0,08175051 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02124911 0,08162197 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02124911 0,08149384 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02124911 0,08136611 ! forebrain regionalization GO:0021871 9 6 0,000 0,02124911 0,08123877 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02124911 0,08111184 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02124911 0,0809853 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02124911 0,08085915 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02124911 0,0807334 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02124911 0,08060804 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02124911 0,08048306 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02124911 0,08035848 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02124911 0,08023427 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02124911 0,08011046 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02124911 0,07998702 ! malate metabolic process GO:0006108 13 6 0,000 0,02124911 0,07986396 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02124911 0,07974128 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02124911 0,07961898 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02124911 0,07949705 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02124911 0,0793755 ! protein refolding GO:0042026 15 6 0,000 0,02124911 0,07925431 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02124911 0,0791335 ! opsonization GO:0008228 8 6 0,000 0,02124911 0,07901305 ! mating behavior GO:0007617 7 6 0,000 0,02124911 0,07889297 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02124911 0,07877326 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02124911 0,0786539 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02124911 0,07853491 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02124911 0,07841628 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02124911 0,078298 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02124911 0,07818008 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02124911 0,07806252 ! toxin metabolic process GO:0009404 11 6 0,000 0,02124911 0,07794531 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02124911 0,07782845 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02124911 0,07771194 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02124911 0,07759578 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02124911 0,07747996 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02124911 0,07736449 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02124911 0,07724937 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02124911 0,07713458 ! thymic T cell selection GO:0045061 16 6 0,000 0,02124911 0,07702014 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02124911 0,07690604 ! protein lipoylation GO:0009249 10 6 0,000 0,02124911 0,07679227 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02124911 0,07667884 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02124911 0,07656574 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02124911 0,07645298 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02124911 0,07634055 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02124911 0,07622845 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02124911 0,07611668 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02124911 0,07600523 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02124911 0,07589412 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02124911 0,07578332 ! hyperosmotic response GO:0006972 10 6 0,000 0,02124911 0,07567285 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02124911 0,0755627 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02124911 0,07545287 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02124911 0,07534336 ! urea metabolic process GO:0019627 7 6 0,000 0,02124911 0,07523417 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02124911 0,07512529 ! neutrophil activation GO:0042119 7 6 0,000 0,02124911 0,07501673 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02124911 0,07490848 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02124911 0,07480054 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02124911 0,07469291 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02124911 0,0745856 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02124911 0,07447859 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02124911 0,07437188 ! neuron apoptosis GO:0051402 15 6 0,000 0,02124911 0,07426549 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02124911 0,07415939 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02124911 0,0740536 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02124911 0,07394811 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02124911 0,07384292 ! carnitine transport GO:0015879 10 6 0,000 0,02124911 0,07373803 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02124911 0,07363344 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02124911 0,07352914 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02124911 0,07342514 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02124911 0,07332143 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02124911 0,07321802 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02124911 0,07311489 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02124911 0,07301206 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02124911 0,07290952 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02124911 0,07280726 ! neural nucleus development GO:0048857 19 6 0,000 0,02124911 0,07270529 ! response to UV-C GO:0010225 14 6 0,000 0,02124911 0,0726036 ! astrocyte development GO:0014002 16 6 0,000 0,02124911 0,0725022 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02124911 0,07240108 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02124911 0,07230024 ! interaction with symbiont GO:0051702 14 6 0,000 0,02124911 0,07219969 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02124911 0,07209941 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02124911 0,07199941 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02124911 0,07189969 ! response to copper ion GO:0046688 10 6 0,000 0,02124911 0,07180024 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02124911 0,07170107 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02124911 0,07160217 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02124911 0,07150355 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02124911 0,07140519 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02124911 0,07130711 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02124911 0,07120929 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02124911 0,07111175 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02124911 0,07101447 ! hair follicle maturation GO:0048820 8 6 0,000 0,02124911 0,07091745 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02124911 0,0708207 ! Schwann cell development GO:0014044 15 6 0,000 0,02124911 0,07072422 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02124911 0,07062799 ! response to pheromone GO:0019236 6 6 0,000 0,02124911 0,07053203 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02124911 0,07043633 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02124911 0,07034089 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02124911 0,0702457 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02124911 0,07015078 ! subpallium development GO:0021544 15 6 0,000 0,02124911 0,07005611 ! neural tube patterning GO:0021532 8 6 0,000 0,02124911 0,06996169 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02124911 0,06986753 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02124911 0,06977362 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02124911 0,06967997 ! G2 phase GO:0051319 16 6 0,000 0,02124911 0,06958656 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02124911 0,06949341 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02124911 0,0694005 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02124911 0,06930784 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02124911 0,06921543 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02124911 0,06912327 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02124911 0,06903135 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02124911 0,06893967 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02124911 0,06884824 ! receptor internalization GO:0031623 11 6 0,000 0,02124911 0,06875705 ! plasminogen activation GO:0031639 9 6 0,000 0,02124911 0,0686661 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02124911 0,0685754 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02124911 0,06848493 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02124911 0,0683947 ! protein deubiquitination GO:0016579 16 6 0,000 0,02124911 0,0683047 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02124911 0,06821495 ! protein destabilization GO:0031648 9 6 0,000 0,02124911 0,06812543 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02124911 0,06803614 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02124911 0,06794709 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02124911 0,06785827 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02124911 0,06776968 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02124911 0,06768132 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02124911 0,0675932 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02124911 0,0675053 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02124911 0,06741763 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02124911 0,06733019 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02124911 0,06724297 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02124911 0,06715598 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02124911 0,06706922 ! neural plate development GO:0001840 9 6 0,000 0,02124911 0,06698268 ! catecholamine transport GO:0051937 9 6 0,000 0,02124911 0,06689636 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02124911 0,06681026 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02124911 0,06672439 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02124911 0,06663874 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02124911 0,0665533 ! maternal placenta development GO:0001893 12 6 0,000 0,02124911 0,06646809 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02124911 0,06638309 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02124911 0,06629831 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02124911 0,06621374 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02124911 0,0661294 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02124911 0,06604526 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02124911 0,06596134 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02124911 0,06587763 GO:0055081|anion homeostasis, ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,0214627 0,06645548 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,02210398 0,06835446 ! positive regulation of cell motion GO:0051272 157 65 1,000 0,02275314 0,07027298 ! ear development GO:0043583 114 66 1,000 0,02341013 0,07221078 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,02407487 0,07416759 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,02407487 0,07407418 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 1,000 0,02407487 0,073981 ! tRNA transcription GO:0009304 17 7 0,000 0,02474681 0,07595033 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02474681 0,07585504 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02474681 0,07575998 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02474681 0,07566516 ! regulation of helicase activity GO:0051095 16 7 0,000 0,02474681 0,07557058 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02474681 0,07547623 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02474681 0,07538212 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02474681 0,07528825 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02474681 0,07519461 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02474681 0,0751012 ! prostate gland development GO:0030850 14 7 0,000 0,02474681 0,07500802 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02474681 0,07491507 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02474681 0,07482236 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02474681 0,07472987 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02474681 0,07463761 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02474681 0,07454558 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02474681 0,07445377 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02474681 0,07436219 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02474681 0,07427084 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02474681 0,07417971 ! glycolipid transport GO:0046836 11 7 0,000 0,02474681 0,0740888 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02474681 0,07399812 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02474681 0,07390766 ! neuron adhesion GO:0007158 14 7 0,000 0,02474681 0,07381742 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02474681 0,07372739 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02474681 0,07363759 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02474681 0,07354801 ! mRNA stabilization GO:0048255 18 7 0,000 0,02474681 0,07345864 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,02474681 0,07336949 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02474681 0,07328056 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02474681 0,07319184 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02474681 0,07310334 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02474681 0,07301505 ! lipoprotein transport GO:0042953 14 7 0,000 0,02474681 0,07292698 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02474681 0,07283911 ! rhythmic behavior GO:0007622 17 7 0,000 0,02474681 0,07275146 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02474681 0,07266402 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02474681 0,07257679 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02474681 0,07248976 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02474681 0,07240295 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02474681 0,07231634 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02474681 0,07222994 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02474681 0,07214375 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02474681 0,07205776 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02474681 0,07197198 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02474681 0,0718864 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02474681 0,07180103 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02474681 0,07171585 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02474681 0,07163088 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02474681 0,07154611 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02474681 0,07146154 ! spinal cord patterning GO:0021511 14 7 0,000 0,02474681 0,07137717 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02474681 0,071293 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02474681 0,07120903 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02474681 0,07112525 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02474681 0,07104167 ! adrenal gland development GO:0030325 17 7 0,000 0,02474681 0,07095829 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02474681 0,0708751 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02474681 0,07079211 ! ovulation GO:0030728 10 7 0,000 0,02474681 0,07070931 ! adenohypophysis development GO:0021984 11 7 0,000 0,02474681 0,07062671 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02474681 0,0705443 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02474681 0,07046208 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02474681 0,07038005 ! microtubule nucleation GO:0007020 21 7 0,000 0,02474681 0,07029821 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02474681 0,07021657 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02474681 0,07013511 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02474681 0,07005384 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02474681 0,06997276 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02474681 0,06989186 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02474681 0,06981116 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02474681 0,06973064 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02474681 0,0696503 ! galactose metabolic process GO:0006012 13 7 0,000 0,02474681 0,06957015 ! vesicle fusion GO:0006906 20 7 0,000 0,02474681 0,06949019 ! response to dietary excess GO:0002021 8 7 0,000 0,02474681 0,06941041 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02474681 0,06933081 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02474681 0,06925139 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02474681 0,06917215 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02474681 0,0690931 ! organ growth GO:0035265 15 7 0,000 0,02474681 0,06901423 ! nucleoside transport GO:0015858 11 7 0,000 0,02474681 0,06893553 ! nucleoside salvage GO:0043174 11 7 0,000 0,02474681 0,06885702 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02474681 0,06877868 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02474681 0,06870053 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02474681 0,06862255 ! parturition GO:0007567 16 7 0,000 0,02474681 0,06854474 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02474681 0,06846712 ! rRNA modification GO:0000154 14 7 0,000 0,02474681 0,06838966 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02474681 0,06831239 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02474681 0,06823529 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02474681 0,06815836 ! monocyte differentiation GO:0030224 16 7 0,000 0,02474681 0,0680816 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02474681 0,06800502 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02474681 0,06792861 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02474681 0,06785237 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02474681 0,0677763 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,02474681 0,06770041 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02474681 0,06762468 ! fibrinolysis GO:0042730 11 7 0,000 0,02474681 0,06754912 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02474681 0,06747373 ! eating behavior GO:0042755 8 7 0,000 0,02474681 0,06739851 ! B cell lineage commitment GO:0002326 21 7 0,000 0,02474681 0,06732346 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02474681 0,06724857 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02474681 0,06717385 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02474681 0,06709929 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02474681 0,0670249 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02474681 0,06695068 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02474681 0,06687662 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02474681 0,06680272 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02474681 0,06672899 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02474681 0,06665542 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02474681 0,06658201 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02474681 0,06650876 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02474681 0,06643567 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02474681 0,06636275 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02474681 0,06628998 ! histone ubiquitination GO:0016574 9 7 0,000 0,02474681 0,06621737 ! regulation of meiosis GO:0040020 12 7 0,000 0,02474681 0,06614493 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02474681 0,06607264 ! T cell lineage commitment GO:0002360 16 7 0,000 0,02474681 0,06600051 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02474681 0,06592853 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02474681 0,06585671 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02474681 0,06578505 ! transcription termination GO:0006353 14 7 0,000 0,02474681 0,06571355 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02474681 0,0656422 ! anaphase GO:0051322 18 7 0,000 0,02474681 0,065571 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02474681 0,06549996 ! axonal fasciculation GO:0007413 19 7 0,000 0,02474681 0,06542907 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02474681 0,06535834 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02474681 0,06528776 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02474681 0,06521733 ! diuresis GO:0030146 12 7 0,000 0,02474681 0,06514705 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02474681 0,06507692 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02474681 0,06500695 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02474681 0,06493712 ! antibiotic transport GO:0042891 9 7 0,000 0,02474681 0,06486745 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02474681 0,06479792 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02474681 0,06472855 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02474681 0,06465932 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02474681 0,06459024 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02474681 0,06452131 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02474681 0,06445252 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02474681 0,06438388 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02474681 0,06431539 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02474681 0,06424704 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02474681 0,06417884 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02474681 0,06411078 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02474681 0,06404286 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02474681 0,06397509 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02474681 0,06390747 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02474681 0,06383998 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02474681 0,06377264 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02474681 0,06370544 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02474681 0,06363838 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02474681 0,06357146 ! muscle adaptation GO:0043500 13 7 0,000 0,02474681 0,06350469 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02474681 0,06343805 ! retina homeostasis GO:0001895 12 7 0,000 0,02474681 0,06337155 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02474681 0,0633052 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02474681 0,06323898 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02474681 0,0631729 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02474681 0,06310696 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,0247473 0,06304239 ! hexose catabolic process GO:0019320 113 68 1,000 0,0247473 0,06297673 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,0247473 0,06291119 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,0247473 0,0628458 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,0247473 0,06278054 ! negative regulation of cell size GO:0045792 144 69 1,000 0,02542737 0,06443886 ! lung development GO:0030324 165 69 1,000 0,02542737 0,06437208 ! urogenital system development GO:0001655 149 69 1,000 0,02542737 0,06430544 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,02681015 0,06773236 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,02681015 0,06766238 ! appendage morphogenesis GO:0035107 150 72 1,000 0,02751274 0,06936389 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 1,000 0,02751274 0,06929238 ! actin filament organization GO:0007015 167 72 1,000 0,02751274 0,06922102 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,02751274 0,06914981 ! appendage development GO:0048736 151 73 1,000 0,02822271 0,07086134 GO:0060173|limb development, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02823211 0,07081217 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02823211 0,07073954 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,02823211 0,07066706 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02823211 0,07059473 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02823211 0,07052255 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02823211 0,07045052 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02823211 0,07037863 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02823211 0,07030689 ! male meiosis GO:0007140 9 8 0,000 0,02823211 0,07023529 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02823211 0,07016384 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02823211 0,07009253 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02823211 0,07002137 ! meiotic prophase I GO:0007128 14 8 0,000 0,02823211 0,06995036 ! response to zinc ion GO:0010043 12 8 0,000 0,02823211 0,06987949 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02823211 0,06980876 ! oligopeptide transport GO:0006857 16 8 0,000 0,02823211 0,06973817 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02823211 0,06966773 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02823211 0,06959743 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02823211 0,06952727 ! signal peptide processing GO:0006465 12 8 0,000 0,02823211 0,06945726 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02823211 0,06938738 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02823211 0,06931764 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02823211 0,06924805 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02823211 0,06917859 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02823211 0,06910927 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02823211 0,06904009 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02823211 0,06897105 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,02823211 0,06890215 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02823211 0,06883339 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02823211 0,06876476 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02823211 0,06869627 ! reflex GO:0060004 17 8 0,000 0,02823211 0,06862791 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02823211 0,0685597 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02823211 0,06849161 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02823211 0,06842367 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02823211 0,06835585 ! pigment granule organization GO:0048753 17 8 0,000 0,02823211 0,06828817 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02823211 0,06822063 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02823211 0,06815322 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02823211 0,06808594 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02823211 0,06801879 ! histidine catabolic process GO:0006548 10 8 0,000 0,02823211 0,06795178 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02823211 0,0678849 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02823211 0,06781815 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02823211 0,06775153 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02823211 0,06768504 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02823211 0,06761868 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02823211 0,06755245 ! melanin metabolic process GO:0006582 17 8 0,000 0,02823211 0,06748635 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02823211 0,06742039 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02823211 0,06735455 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02823211 0,06728883 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02823211 0,06722325 ! macrophage activation GO:0042116 13 8 0,000 0,02823211 0,06715779 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02823211 0,06709247 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02823211 0,06702726 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02823211 0,06696219 ! purine salvage GO:0043101 12 8 0,000 0,02823211 0,06689724 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02823211 0,06683242 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02823211 0,06676772 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02823211 0,06670315 ! osteoblast development GO:0002076 17 8 0,000 0,02823211 0,0666387 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02823211 0,06657438 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02823211 0,06651018 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02823211 0,0664461 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02823211 0,06638215 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02823211 0,06631832 ! response to UV-B GO:0010224 17 8 0,000 0,02823211 0,06625462 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02823211 0,06619103 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02823211 0,06612757 ! intermediate filament organization GO:0045109 12 8 0,000 0,02823211 0,06606423 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02823211 0,06600101 ! cellular extravasation GO:0045123 13 8 0,000 0,02823211 0,06593791 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02823211 0,06587493 ! response to antibiotic GO:0046677 11 8 0,000 0,02823211 0,06581207 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02823211 0,06574934 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02823211 0,06568672 ! DNA topological change GO:0006265 12 8 0,000 0,02823211 0,06562422 ! response to tropane GO:0014073 15 8 0,000 0,02823211 0,06556184 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,02823211 0,06549958 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02823211 0,06543743 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02823211 0,06537541 ! mast cell activation GO:0045576 14 8 0,000 0,02823211 0,0653135 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02823211 0,06525171 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02823211 0,06519003 ! gas homeostasis GO:0033483 14 8 0,000 0,02823211 0,06512847 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02823211 0,06506703 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02823211 0,06500571 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02823211 0,0649445 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02823211 0,0648834 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02823211 0,06482242 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02823211 0,06476155 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02823211 0,0647008 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02823211 0,06464016 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02823211 0,06457964 ! response to tumor cell GO:0002347 16 8 0,000 0,02823211 0,06451923 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02823211 0,06445893 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02823211 0,06439874 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02823211 0,06433867 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02823211 0,06427871 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02823211 0,06421886 ! hormone catabolic process GO:0042447 17 8 0,000 0,02823211 0,06415912 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02823211 0,06409949 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02823211 0,06403998 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02823211 0,06398057 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02823211 0,06392127 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02823211 0,06386209 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02823211 0,06380301 ! adult feeding behavior GO:0008343 10 8 0,000 0,02823211 0,06374404 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02823211 0,06368518 ! ATP catabolic process GO:0006200 11 8 0,000 0,02823211 0,06362643 ! blastocyst growth GO:0001832 19 8 0,000 0,02823211 0,06356779 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02823211 0,06350926 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02823211 0,06345083 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02823211 0,06339251 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02823211 0,0633343 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02823211 0,0632762 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02823211 0,0632182 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02823211 0,06316031 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02823211 0,06310252 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02823211 0,06304484 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02823211 0,06298726 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02823211 0,06292979 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02823211 0,06287243 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02823211 0,06281517 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02823211 0,06275801 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02823211 0,06270096 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02823211 0,06264401 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02823211 0,06258716 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02823211 0,06253042 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02823211 0,06247378 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02823211 0,06241724 ! acute inflammatory response GO:0002526 118 74 1,000 0,02894001 0,06392445 ! regulation of caspase activity GO:0043281 136 74 1,000 0,02894001 0,0638667 ! respiratory system development GO:0060541 175 74 1,000 0,02894001 0,06380906 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,02966457 0,06534765 ! axon guidance GO:0007411 162 75 1,000 0,02966457 0,06528878 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,03039634 0,06683911 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,03039634 0,066779 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,03113524 0,06834088 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,03113524 0,06827953 ! monosaccharide catabolic process GO:0046365 125 77 1,000 0,03113524 0,0682183 ! axon extension GO:0048675 16 9 0,000 0,03170506 0,06940453 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03170506 0,0693424 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03170506 0,06928037 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03170506 0,06921846 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03170506 0,06915666 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03170506 0,06909496 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03170506 0,06903338 ! reproductive behavior GO:0019098 22 9 0,000 0,03170506 0,06897191 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03170506 0,06891055 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03170506 0,06884929 GO:0010469|regulation of receptor activity, ! UTP metabolic process GO:0046051 10 9 0,000 0,03170506 0,06878815 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03170506 0,06872711 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03170506 0,06866618 ! artery development GO:0060840 25 9 0,000 0,03170506 0,06860536 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03170506 0,06854465 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03170506 0,06848405 ! equilibrioception GO:0050957 20 9 0,000 0,03170506 0,06842355 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03170506 0,06836316 ! chemosensory behavior GO:0007635 21 9 0,000 0,03170506 0,06830287 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03170506 0,06824269 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03170506 0,06818262 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03170506 0,06812265 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03170506 0,06806279 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03170506 0,06800303 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03170506 0,06794338 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03170506 0,06788383 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03170506 0,06782439 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03170506 0,06776505 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03170506 0,06770582 ! protein targeting to ER GO:0045047 25 9 0,000 0,03170506 0,06764669 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03170506 0,06758766 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03170506 0,06752873 ! T cell selection GO:0045058 27 9 0,000 0,03170506 0,06746991 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03170506 0,06741119 ! glycine catabolic process GO:0006546 15 9 0,000 0,03170506 0,06735257 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03170506 0,06729405 ! endosome organization GO:0007032 20 9 0,000 0,03170506 0,06723564 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03170506 0,06717732 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03170506 0,06711911 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03170506 0,067061 ! mannose metabolic process GO:0006013 13 9 0,000 0,03170506 0,06700299 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03170506 0,06694508 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03170506 0,06688727 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03170506 0,06682956 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03170506 0,06677194 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03170506 0,06671443 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03170506 0,06665702 ! retinol metabolic process GO:0042572 20 9 0,000 0,03170506 0,0665997 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03170506 0,06654249 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03170506 0,06648537 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03170506 0,06642835 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03170506 0,06637143 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03170506 0,0663146 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03170506 0,06625787 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03170506 0,06620124 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03170506 0,06614471 ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03170506 0,06608827 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03170506 0,06603193 ! erythrocyte development GO:0048821 17 9 0,000 0,03170506 0,06597569 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03170506 0,06591954 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03170506 0,06586348 ! renal water homeostasis GO:0003091 15 9 0,000 0,03170506 0,06580752 ! postreplication repair GO:0006301 25 9 0,000 0,03170506 0,06575166 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03170506 0,06569589 ! icosanoid secretion GO:0032309 15 9 0,000 0,03170506 0,06564022 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03170506 0,06558464 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03170506 0,06552915 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03170506 0,06547376 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03170506 0,06541846 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03170506 0,06536325 ! sterol catabolic process GO:0016127 14 9 0,000 0,03170506 0,06530814 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03170506 0,06525312 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03170506 0,06519819 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03170506 0,06514336 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03170506 0,06508862 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03170506 0,06503397 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03170506 0,06497941 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03170506 0,06492494 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03170506 0,06487057 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03170506 0,06481628 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03170506 0,06476209 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03170506 0,06470798 ! purine base metabolic process GO:0006144 25 9 0,000 0,03170506 0,06465397 ! pigment granule transport GO:0051904 17 9 0,000 0,03170506 0,06460005 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03170506 0,06454621 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03170506 0,06449247 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03170506 0,06443881 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03170506 0,06438525 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03170506 0,06433177 ! mitochondrion localization GO:0051646 18 9 0,000 0,03170506 0,06427839 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,03188124 0,06458197 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,03263425 0,0660526 ! protein oligomerization GO:0051259 149 79 1,000 0,03263425 0,06599792 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,03263425 0,06594333 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,03339424 0,06742324 ! meiosis GO:0007126 143 81 1,000 0,03416113 0,06891465 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 1,000 0,03416113 0,06885779 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,03416113 0,06880102 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,03493487 0,07030139 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,03493487 0,07024353 ! meiotic cell cycle GO:0051321 144 82 1,000 0,03493487 0,07018576 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,03516569 0,07059143 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,03516569 0,07053347 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03516569 0,07047561 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,03516569 0,07041785 ! associative learning GO:0008306 21 10 0,000 0,03516569 0,07036017 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03516569 0,0703026 ! phosphate transport GO:0006817 24 10 0,000 0,03516569 0,07024511 ! cell volume homeostasis GO:0006884 17 10 0,000 0,03516569 0,07018772 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,03516569 0,07013043 ! CTP metabolic process GO:0046036 11 10 0,000 0,03516569 0,07007322 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,03516569 0,07001611 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,03516569 0,0699591 ! GTP metabolic process GO:0046039 11 10 0,000 0,03516569 0,06990217 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,03516569 0,06984534 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,03516569 0,0697886 ! social behavior GO:0035176 29 10 0,000 0,03516569 0,06973196 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,03516569 0,0696754 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,03516569 0,06961894 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,03516569 0,06956257 ! androgen metabolic process GO:0008209 17 10 0,000 0,03516569 0,06950629 ! phospholipid efflux GO:0033700 19 10 0,000 0,03516569 0,0694501 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03516569 0,069394 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,03516569 0,06933799 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,03516569 0,06928207 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,03516569 0,06922625 ! lung alveolus development GO:0048286 26 10 0,000 0,03516569 0,06917051 ! pathogenesis GO:0009405 17 10 0,000 0,03516569 0,06911486 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03516569 0,0690593 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,03516569 0,06900383 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,03516569 0,06894845 ! endoderm development GO:0007492 18 10 0,000 0,03516569 0,06889316 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,03516569 0,06883796 ! arginine catabolic process GO:0006527 17 10 0,000 0,03516569 0,06878284 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03516569 0,06872782 ! proline metabolic process GO:0006560 13 10 0,000 0,03516569 0,06867288 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03516569 0,06861803 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,03516569 0,06856327 ! V(D)J recombination GO:0033151 34 10 0,000 0,03516569 0,06850859 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,03516569 0,068454 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,03516569 0,0683995 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,03516569 0,06834509 ! B cell proliferation GO:0042100 19 10 0,000 0,03516569 0,06829076 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,03516569 0,06823652 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,03516569 0,06818236 ! multicellular organism growth GO:0035264 19 10 0,000 0,03516569 0,06812829 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,03516569 0,0680743 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,03516569 0,06802041 ! ruffle organization GO:0031529 17 10 0,000 0,03516569 0,06796659 ! epithelial cell development GO:0002064 21 10 0,000 0,03516569 0,06791286 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,03516569 0,06785922 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03516569 0,06780566 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,03516569 0,06775219 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,03516569 0,0676988 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,03516569 0,06764549 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,03516569 0,06759227 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,03516569 0,06753913 ! copper ion homeostasis GO:0055070 13 10 0,000 0,03516569 0,06748607 ! regulation of bone resorption GO:0045124 25 10 0,000 0,03516569 0,0674331 ! brain morphogenesis GO:0048854 23 10 0,000 0,03516569 0,06738021 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,03516569 0,06732741 ! segment specification GO:0007379 15 10 0,000 0,03516569 0,06727468 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,03516569 0,06722204 ! blastoderm segmentation GO:0007350 19 10 0,000 0,03516569 0,06716949 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,03516569 0,06711701 ! response to dsRNA GO:0043331 23 10 0,000 0,03516569 0,06706462 ! DNA ligation GO:0006266 18 10 0,000 0,03516569 0,0670123 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,03516569 0,06696007 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03516569 0,06690792 ! melanosome localization GO:0032400 16 10 0,000 0,03516569 0,06685585 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,03516569 0,06680387 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,03516569 0,06675196 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,03516569 0,06670013 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03516569 0,06664839 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,03516569 0,06659672 ! induction of an organ GO:0001759 17 10 0,000 0,03516569 0,06654514 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,03516569 0,06649363 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,03516569 0,06644221 ! protein sumoylation GO:0016925 17 10 0,000 0,03516569 0,06639086 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,03516569 0,06633959 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03516569 0,0662884 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03516569 0,0662373 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03516569 0,06618627 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,03516569 0,06613531 ! salivary gland development GO:0007431 28 10 0,000 0,03516569 0,06608444 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,03516569 0,06603365 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,03516569 0,06598293 ! midbrain development GO:0030901 14 10 0,000 0,03516569 0,06593229 ! musculoskeletal movement GO:0050881 16 10 0,000 0,03516569 0,06588173 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,03516569 0,06583124 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,03516569 0,06578084 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,03516569 0,06573051 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,03516569 0,06568025 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,03516569 0,06563008 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03516569 0,06557998 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03516569 0,06552996 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,03516569 0,06548001 ! detection of calcium ion GO:0005513 24 10 0,000 0,03516569 0,06543014 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03516569 0,06538034 ! blastocyst formation GO:0001825 18 10 0,000 0,03516569 0,06533063 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,03516569 0,06528098 ! cerebellar cortex development GO:0021695 16 10 0,000 0,03516569 0,06523141 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,03516569 0,06518192 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,03516569 0,0651325 ! response to nicotine GO:0035094 20 10 0,000 0,03516569 0,06508316 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,03516569 0,06503389 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,03516569 0,0649847 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,0357154 0,06595066 ! response to drug GO:0042493 149 83 1,000 0,0357154 0,06590085 ! response to oxygen levels GO:0070482 183 83 1,000 0,0357154 0,06585111 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,0357154 0,06580145 ! response to metal ion GO:0010038 158 84 1,000 0,03650267 0,06720121 ! T cell activation GO:0042110 189 84 1,000 0,03650267 0,06715061 ! regulation of ligase activity GO:0051340 147 84 1,000 0,03650267 0,06710008 ! negative regulation of growth GO:0045926 168 85 1,000 0,03729661 0,06850798 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,03729661 0,06845651 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,03729661 0,06840511 ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,03729661 0,0683538 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,03809717 0,06976865 ! regulation of lyase activity GO:0051339 169 86 1,000 0,03809717 0,06971639 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,03809717 0,06966421 GO:0002696|positive regulation of leukocyte activation, ! respiratory burst GO:0045730 17 11 0,000 0,03861404 0,07055655 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03861404 0,07050382 ! neuron fate specification GO:0048665 18 11 0,000 0,03861404 0,07045117 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03861404 0,07039859 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03861404 0,07034609 ! thyroid gland development GO:0030878 26 11 0,000 0,03861404 0,07029367 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,03861404 0,07024133 ! synapsis GO:0007129 14 11 0,000 0,03861404 0,07018907 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03861404 0,07013689 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03861404 0,07008478 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03861404 0,07003275 ! response to pain GO:0048265 27 11 0,000 0,03861404 0,06998079 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03861404 0,06992892 ! blood vessel remodeling GO:0001974 30 11 0,000 0,03861404 0,06987712 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03861404 0,0698254 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,03861404 0,06977375 ! bone resorption GO:0045453 16 11 0,000 0,03861404 0,06972218 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03861404 0,06967069 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03861404 0,06961927 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03861404 0,06956793 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03861404 0,06951666 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03861404 0,06946547 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03861404 0,06941436 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03861404 0,06936332 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of intracellular pH GO:0051453 21 11 0,000 0,03861404 0,06931235 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03861404 0,06926146 ! UV protection GO:0009650 20 11 0,000 0,03861404 0,06921065 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03861404 0,06915991 ! macroautophagy GO:0016236 19 11 0,000 0,03861404 0,06910924 ! temperature homeostasis GO:0001659 18 11 0,000 0,03861404 0,06905865 ! behavioral fear response GO:0001662 27 11 0,000 0,03861404 0,06900813 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03861404 0,06895768 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03861404 0,06890731 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03861404 0,06885702 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03861404 0,06880679 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03861404 0,06875664 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03861404 0,06870656 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03861404 0,06865656 ! regulation of organ growth GO:0046620 14 11 0,000 0,03861404 0,06860663 ! pigment granule localization GO:0051875 20 11 0,000 0,03861404 0,06855677 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03861404 0,06850698 ! vasoconstriction GO:0042310 20 11 0,000 0,03861404 0,06845727 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03861404 0,06840762 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03861404 0,06835805 ! embryonic axis specification GO:0000578 19 11 0,000 0,03861404 0,06830855 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03861404 0,06825913 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03861404 0,06820977 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03861404 0,06816049 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03861404 0,06811127 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03861404 0,06806213 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03861404 0,06801306 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03861404 0,06796406 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03861404 0,06791513 ! prophase GO:0051324 17 11 0,000 0,03861404 0,06786627 ! nucleosome positioning GO:0016584 15 11 0,000 0,03861404 0,06781748 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03861404 0,06776876 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03861404 0,06772011 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03861404 0,06767153 ! apical protein localization GO:0045176 18 11 0,000 0,03861404 0,06762302 ! acid secretion GO:0046717 20 11 0,000 0,03861404 0,06757458 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03861404 0,06752621 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03861404 0,06747791 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,03861404 0,06742967 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03861404 0,06738151 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03861404 0,06733341 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03861404 0,06728539 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03861404 0,06723743 ! cholesterol efflux GO:0033344 21 11 0,000 0,03861404 0,06718954 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03861404 0,06714172 ! oocyte development GO:0048599 20 11 0,000 0,03861404 0,06709396 ! germ cell migration GO:0008354 26 11 0,000 0,03861404 0,06704628 ! embryonic gut development GO:0048566 19 11 0,000 0,03861404 0,06699866 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03861404 0,06695111 ! activation of innate immune response GO:0002218 16 11 0,000 0,03861404 0,06690363 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03861404 0,06685621 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03861404 0,06680886 ! lysogeny GO:0030069 22 11 0,000 0,03861404 0,06676158 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03861404 0,06671436 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03861404 0,06666722 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03861404 0,06662014 ! mitochondrion organization GO:0007005 159 87 1,000 0,03890429 0,06707353 ! alcohol catabolic process GO:0046164 142 87 1,000 0,03890429 0,06702623 ! regulation of protein transport GO:0051223 165 87 1,000 0,03890429 0,06697899 GO:0070201|regulation of establishment of protein localization, ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,04053801 0,0697425 ! regulation of neurological system process GO:0031644 175 89 1,000 0,04053801 0,06969342 ! response to inorganic substance GO:0010035 173 90 1,000 0,04136448 0,0710643 ! oxidative phosphorylation GO:0006119 152 90 1,000 0,04136448 0,07101436 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,04205018 0,07214086 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,04205018 0,07209023 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,04205018 0,07203968 ! mating GO:0007618 17 12 0,000 0,04205018 0,07198919 ! protein complex disassembly GO:0043241 28 12 0,000 0,04205018 0,07193878 GO:0043624|cellular protein complex disassembly, ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,04205018 0,07188844 ! T cell proliferation GO:0042098 32 12 0,000 0,04205018 0,07183817 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,04205018 0,07178796 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,04205018 0,07173783 ! ventral spinal cord development GO:0021517 25 12 0,000 0,04205018 0,07168777 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,04205018 0,07163778 ! drug transport GO:0015893 16 12 0,000 0,04205018 0,07158786 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,04205018 0,07153801 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,04205018 0,07148822 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,04205018 0,07143851 ! polyamine metabolic process GO:0006595 18 12 0,000 0,04205018 0,07138887 ! focal adhesion formation GO:0048041 37 12 0,000 0,04205018 0,07133929 ! mitotic spindle organization GO:0007052 23 12 0,000 0,04205018 0,07128978 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,04205018 0,07124035 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,04205018 0,07119098 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,04205018 0,07114167 ! lipid digestion GO:0044241 21 12 0,000 0,04205018 0,07109244 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,04205018 0,07104328 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04205018 0,07099418 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,04205018 0,07094515 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,04205018 0,07089619 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,04205018 0,07084729 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,04205018 0,07079847 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,04205018 0,07074971 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,04205018 0,07070102 ! snRNA metabolic process GO:0016073 30 12 0,000 0,04205018 0,07065239 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,04205018 0,07060383 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,04205018 0,07055534 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,04205018 0,07050692 ! cranial nerve development GO:0021545 23 12 0,000 0,04205018 0,07045856 ! fucose catabolic process GO:0019317 25 12 0,000 0,04205018 0,07041027 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,04205018 0,07036204 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,04205018 0,07031388 ! autonomic nervous system development GO:0048483 24 12 0,000 0,04205018 0,07026578 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,04205018 0,07021776 ! zymogen activation GO:0031638 18 12 0,000 0,04205018 0,07016979 ! T cell homeostasis GO:0043029 28 12 0,000 0,04205018 0,0701219 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,04205018 0,07007406 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,04205018 0,0700263 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,04205018 0,0699786 ! oocyte differentiation GO:0009994 21 12 0,000 0,04205018 0,06993096 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,04205018 0,06988339 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,04205018 0,06983588 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,04205018 0,06978844 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,04205018 0,06974106 ! defense response to fungus GO:0050832 15 12 0,000 0,04205018 0,06969374 ! developmental induction GO:0031128 22 12 0,000 0,04205018 0,06964649 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,04205018 0,06959931 ! lamellipodium assembly GO:0030032 24 12 0,000 0,04205018 0,06955219 ! response to cold GO:0009409 17 12 0,000 0,04205018 0,06950513 ! establishment of cell polarity GO:0030010 21 12 0,000 0,04205018 0,06945813 ! regulation of synapse organization GO:0050807 18 12 0,000 0,04205018 0,0694112 ! localization within membrane GO:0051668 26 12 0,000 0,04205018 0,06936433 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,0421973 0,06956005 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! gland development GO:0048732 220 91 1,000 0,0421973 0,06951315 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,0430364 0,07084766 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,04388173 0,07219062 GO:0010498|proteasomal protein catabolic process, ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04547412 0,07475994 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04547412 0,07470967 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04547412 0,07465946 ! regulation of chemokine production GO:0032642 18 13 0,000 0,04547412 0,07460932 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,04547412 0,07455925 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04547412 0,07450924 ! peroxisomal transport GO:0043574 28 13 0,000 0,04547412 0,0744593 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04547412 0,07440943 ! cartilage condensation GO:0001502 22 13 0,000 0,04547412 0,07435962 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,04547412 0,07430988 ! organelle fusion GO:0048284 36 13 0,000 0,04547412 0,07426021 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04547412 0,07421061 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04547412 0,07416107 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,04547412 0,07411159 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04547412 0,07406218 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04547412 0,07401284 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04547412 0,07396357 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04547412 0,07391436 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04547412 0,07386521 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04547412 0,07381613 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,04547412 0,07376712 ! methionine metabolic process GO:0006555 31 13 0,000 0,04547412 0,07371817 ! plasma membrane organization GO:0007009 27 13 0,000 0,04547412 0,07366928 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04547412 0,07362046 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04547412 0,07357171 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04547412 0,07352302 ! response to X-ray GO:0010165 28 13 0,000 0,04547412 0,07347439 ! cytokine metabolic process GO:0042107 24 13 0,000 0,04547412 0,07342583 ! exocrine system development GO:0035272 34 13 0,000 0,04547412 0,07337733 ! asymmetric protein localization GO:0008105 24 13 0,000 0,04547412 0,0733289 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,04547412 0,07328053 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,04547412 0,07323222 ! L-glutamate transport GO:0015813 30 13 0,000 0,04547412 0,07318398 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,04547412 0,0731358 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04547412 0,07308768 ! protein homotetramerization GO:0051289 24 13 0,000 0,04547412 0,07303963 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04547412 0,07299164 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04547412 0,07294371 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04547412 0,07289585 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04547412 0,07284805 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04547412 0,07280031 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04547412 0,07275264 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,04547412 0,07270502 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04547412 0,07265747 ! histone methylation GO:0016571 29 13 0,000 0,04547412 0,07260998 ! chromatin silencing GO:0006342 29 13 0,000 0,04547412 0,07256256 ! gland morphogenesis GO:0022612 31 13 0,000 0,04547412 0,07251519 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04547412 0,07246789 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,04547412 0,07242065 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04547412 0,07237347 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04547412 0,07232635 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04547412 0,07227929 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04547412 0,0722323 ! spleen development GO:0048536 24 13 0,000 0,04547412 0,07218536 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,04547412 0,07213849 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,04547412 0,07209168 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04547412 0,07204493 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04547412 0,07199823 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04547412 0,0719516 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04547412 0,07190503 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04547412 0,07185852 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04547412 0,07181207 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04547412 0,07176568 ! insulin secretion GO:0030073 24 13 0,000 0,04547412 0,07171935 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04547412 0,07167308 ! acrosome reaction GO:0007340 19 13 0,000 0,04547412 0,07162687 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04547412 0,07158072 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04547412 0,07153463 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,04559086 0,07167212 ! regulation of T cell activation GO:0050863 175 96 1,000 0,04645456 0,07298295 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,04732426 0,07430153 ! regulation of protein localization GO:0032880 188 97 1,000 0,04732426 0,07425381 ! forebrain development GO:0030900 210 98 1,000 0,04819993 0,07557923 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,04819993 0,07553075 ! rRNA transcription GO:0009303 28 14 0,000 0,04888592 0,07655661 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04888592 0,07650757 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04888592 0,07645859 ! water transport GO:0006833 21 14 0,000 0,04888592 0,07640967 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04888592 0,07636081 ! non-recombinational repair GO:0000726 29 14 0,000 0,04888592 0,07631202 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04888592 0,07626329 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04888592 0,07621462 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04888592 0,07616602 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04888592 0,07611747 ! lipid localization GO:0010876 32 14 0,000 0,04888592 0,07606899 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04888592 0,07602057 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04888592 0,07597221 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04888592 0,07592391 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04888592 0,07587567 ! arginine metabolic process GO:0006525 21 14 0,000 0,04888592 0,0758275 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04888592 0,07577939 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04888592 0,07573133 ! regulation of heart rate GO:0002027 25 14 0,000 0,04888592 0,07568334 ! fear response GO:0042596 34 14 0,000 0,04888592 0,07563541 ! organic alcohol transport GO:0015850 29 14 0,000 0,04888592 0,07558754 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04888592 0,07553973 ! embryo implantation GO:0007566 30 14 0,000 0,04888592 0,07549198 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04888592 0,07544429 ! bone mineralization GO:0030282 18 14 0,000 0,04888592 0,07539666 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04888592 0,07534909 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,04888592 0,07530158 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04888592 0,07525413 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04888592 0,07520675 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04888592 0,07515942 ! regulation of cellular pH GO:0030641 27 14 0,000 0,04888592 0,07511215 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04888592 0,07506494 ! ribosome assembly GO:0042255 18 14 0,000 0,04888592 0,07501778 ! cerebellum development GO:0021549 23 14 0,000 0,04888592 0,07497069 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04888592 0,07492366 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04888592 0,07487668 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04888592 0,07482977 ! response to gamma radiation GO:0010332 30 14 0,000 0,04888592 0,07478291 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04888592 0,07473612 ! NADP metabolic process GO:0006739 24 14 0,000 0,04888592 0,07468938 ! oxygen transport GO:0015671 22 14 0,000 0,04888592 0,07464269 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04888592 0,07459607 ! male genitalia development GO:0030539 26 14 0,000 0,04888592 0,07454951 ! regulation of RNA stability GO:0043487 33 14 0,000 0,04888592 0,074503 ! regulation of axon extension GO:0030516 43 14 0,000 0,04888592 0,07445655 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04888592 0,07441016 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04888592 0,07436383 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,05228563 0,07948587 ! lactation GO:0007595 30 15 0,000 0,05228563 0,07943644 ! reproductive cellular process GO:0048610 22 15 0,000 0,05228563 0,07938707 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,05228563 0,07933776 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,05228563 0,07928851 ! superoxide anion generation GO:0042554 22 15 0,000 0,05228563 0,07923932 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,05228563 0,0791902 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,05228563 0,07914113 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,05228563 0,07909213 ! copper ion transport GO:0006825 22 15 0,000 0,05228563 0,07904319 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,05228563 0,0789943 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,05228563 0,07894548 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,05228563 0,07889672 ! sulfate transport GO:0008272 27 15 0,000 0,05228563 0,07884802 ! response to cAMP GO:0051591 25 15 0,000 0,05228563 0,07879938 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,05228563 0,07875079 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,05228563 0,07870227 ! response to hexose stimulus GO:0009746 25 15 0,000 0,05228563 0,07865381 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,05228563 0,07860541 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,05228563 0,07855707 ! vesicle coating GO:0006901 38 15 0,000 0,05228563 0,07850878 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,05228563 0,07846056 ! regulation of exocytosis GO:0017157 26 15 0,000 0,05228563 0,07841239 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,05228563 0,07836429 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,05228563 0,07831624 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,05228563 0,07826825 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,05228563 0,07822032 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,05228563 0,07817245 ! regulation of vasodilation GO:0042312 27 15 0,000 0,05228563 0,07812464 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,05228563 0,07807689 ! histone deacetylation GO:0016575 24 15 0,000 0,05228563 0,07802919 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,05228563 0,07798156 ! water homeostasis GO:0030104 28 15 0,000 0,05228563 0,07793398 ! cofactor transport GO:0051181 30 15 0,000 0,05228563 0,07788646 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,05228563 0,07783899 ! muscle maintenance GO:0046716 26 15 0,000 0,05228563 0,07779159 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,05228563 0,07774424 ! intestinal absorption GO:0050892 31 15 0,000 0,05228563 0,07769695 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,05228563 0,07764972 ! heme biosynthetic process GO:0006783 33 15 0,000 0,05228563 0,07760255 ! cell killing GO:0001906 32 15 0,000 0,05228563 0,07755543 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,05228563 0,07750837 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,05228563 0,07746136 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,05228563 0,07741442 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,05228563 0,07736753 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,05228563 0,0773207 ! actin filament polymerization GO:0030041 27 15 0,000 0,05228563 0,07727392 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,05228563 0,0772272 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05567328 0,08218116 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05567328 0,08213153 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05567328 0,08208196 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05567328 0,08203246 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05567328 0,08198301 ! bone remodeling GO:0046849 28 16 0,000 0,05567328 0,08193362 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,05567328 0,08188429 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05567328 0,08183503 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05567328 0,08178582 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05567328 0,08173667 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05567328 0,08168757 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05567328 0,08163854 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,05567328 0,08158957 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05567328 0,08154065 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05567328 0,0814918 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05567328 0,081443 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05567328 0,08139426 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05567328 0,08134558 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05567328 0,08129696 ! pituitary gland development GO:0021983 30 16 0,000 0,05567328 0,08124839 ! response to osmotic stress GO:0006970 27 16 0,000 0,05567328 0,08119989 ! lysosomal transport GO:0007041 31 16 0,000 0,05567328 0,08115144 ! fructose metabolic process GO:0006000 25 16 0,000 0,05567328 0,08110305 ! L-amino acid transport GO:0015807 33 16 0,000 0,05567328 0,08105471 ! stem cell development GO:0048864 46 16 0,000 0,05567328 0,08100644 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05567328 0,08095822 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05567328 0,08091006 ! intermediate filament-based process GO:0045103 36 16 0,000 0,05567328 0,08086196 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,05567328 0,08081391 ! negative regulation of immune response GO:0050777 38 16 0,000 0,05567328 0,08076592 ! axon cargo transport GO:0008088 46 16 0,000 0,05567328 0,08071799 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05567328 0,08067011 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05567328 0,0806223 ! DNA replication initiation GO:0006270 28 16 0,000 0,05567328 0,08057453 ! neuron recognition GO:0008038 40 16 0,000 0,05567328 0,08052683 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05567328 0,08047918 ! tissue regeneration GO:0042246 27 16 0,000 0,05567328 0,08043159 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05567328 0,08038405 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05567328 0,08033657 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,05567328 0,08028915 ! biomineral formation GO:0031214 22 16 0,000 0,05567328 0,08024178 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05567328 0,08019446 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05567328 0,08014721 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05567328 0,08010001 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05567328 0,08005286 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05567328 0,08000577 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05567328 0,07995874 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,05567328 0,07991176 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,05567328 0,07986483 ! peptide hormone processing GO:0016486 27 16 0,000 0,05567328 0,07981796 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,05904891 0,08460791 ! metencephalon development GO:0022037 32 17 0,000 0,05904891 0,08455831 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,05904891 0,08450878 ! endothelial cell migration GO:0043542 31 17 0,000 0,05904891 0,0844593 ! gene silencing by RNA GO:0031047 38 17 0,000 0,05904891 0,08440988 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,05904891 0,08436052 ! glial cell development GO:0021782 28 17 0,000 0,05904891 0,08431121 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,05904891 0,08426196 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,05904891 0,08421277 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,05904891 0,08416364 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,05904891 0,08411457 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,05904891 0,08406555 ! myoblast differentiation GO:0045445 50 17 0,000 0,05904891 0,08401659 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,05904891 0,08396769 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,05904891 0,08391884 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,05904891 0,08387005 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,05904891 0,08382132 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,05904891 0,08377264 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,05904891 0,08372402 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,05904891 0,08367545 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,05904891 0,08362695 ! membrane budding GO:0006900 42 17 0,000 0,05904891 0,0835785 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,05904891 0,0835301 ! regulation of protein binding GO:0043393 33 17 0,000 0,05904891 0,08348176 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,05904891 0,08343348 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,05904891 0,08338525 ! genitalia development GO:0048806 32 17 0,000 0,05904891 0,08333708 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,05904891 0,08328896 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,05904891 0,0832409 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,05904891 0,0831929 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,05904891 0,08314495 ! steroid catabolic process GO:0006706 34 17 0,000 0,05904891 0,08309705 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,05904891 0,08304921 ! gas transport GO:0015669 26 17 0,000 0,05904891 0,08300143 ! organic cation transport GO:0015695 32 17 0,000 0,05904891 0,0829537 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,05904891 0,08290603 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,05904891 0,08285841 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,05904891 0,08281084 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,06241257 0,08747786 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,06241257 0,0874277 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,06241257 0,0873776 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,06241257 0,08732755 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,06241257 0,08727757 ! adult walking behavior GO:0007628 36 18 0,000 0,06241257 0,08722764 ! patterning of blood vessels GO:0001569 43 18 0,000 0,06241257 0,08717776 ! heart looping GO:0001947 34 18 0,000 0,06241257 0,08712795 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,06241257 0,08707819 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,06241257 0,08702849 ! centrosome cycle GO:0007098 26 18 0,000 0,06241257 0,08697884 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,06241257 0,08692925 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,06241257 0,08687972 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,06241257 0,08683024 ! glycine metabolic process GO:0006544 30 18 0,000 0,06241257 0,08678082 ! glutamine metabolic process GO:0006541 29 18 0,000 0,06241257 0,08673146 ! response to retinoic acid GO:0032526 31 18 0,000 0,06241257 0,08668215 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,06241257 0,0866329 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,06241257 0,08658371 ! DNA integration GO:0015074 32 18 0,000 0,06241257 0,08653457 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,06241257 0,08648548 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,06241257 0,08643646 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,06241257 0,08638748 ! neural crest cell migration GO:0001755 41 18 0,000 0,06241257 0,08633857 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,06241257 0,0862897 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,06241257 0,0862409 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,06241257 0,08619215 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,06241257 0,08614345 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,06241257 0,08609481 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,06241257 0,08604622 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,06241257 0,08599769 ! detection of bacterium GO:0016045 22 18 0,000 0,06241257 0,08594922 ! nerve development GO:0021675 34 18 0,000 0,06241257 0,08590079 ! defense response to virus GO:0051607 43 18 0,000 0,06241257 0,08585243 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,06241257 0,08580411 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,06241257 0,08575585 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,0657643 0,09031039 ! positive regulation of translation GO:0045727 31 19 0,000 0,0657643 0,09025966 ! negative regulation of defense response GO:0031348 27 19 0,000 0,0657643 0,09020898 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,0657643 0,09015835 ! neuron maturation GO:0042551 46 19 0,000 0,0657643 0,09010779 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,0657643 0,09005728 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,0657643 0,09000683 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,0657643 0,08995643 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,0657643 0,08990609 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,0657643 0,08985581 ! inositol metabolic process GO:0006020 33 19 0,000 0,0657643 0,08980558 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,0657643 0,08975541 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,0657643 0,0897053 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,0657643 0,08965524 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,0657643 0,08960524 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,0657643 0,08955529 ! cerebral cortex development GO:0021987 40 19 0,000 0,0657643 0,0895054 ! response to vitamin A GO:0033189 32 19 0,000 0,0657643 0,08945556 ! heme metabolic process GO:0042168 40 19 0,000 0,0657643 0,08940578 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,0657643 0,08935606 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,0657643 0,08930639 ! response to fungus GO:0009620 26 19 0,000 0,0657643 0,08925677 ! peptide cross-linking GO:0018149 39 19 0,000 0,0657643 0,08920721 ! protein export from nucleus GO:0006611 40 19 0,000 0,0657643 0,08915771 ! heart process GO:0003015 32 19 0,000 0,0657643 0,08910826 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,0657643 0,08905886 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,0657643 0,08900952 ! cellular pigmentation GO:0033059 37 19 0,000 0,0657643 0,08896024 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,0657643 0,08891101 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,0657643 0,08886183 ! vitamin transport GO:0051180 31 19 0,000 0,0657643 0,08881271 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,0657643 0,08876364 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,0657643 0,08871463 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,0657643 0,08866567 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,0657643 0,08861676 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,0657643 0,08856791 ! cilium assembly GO:0042384 38 19 0,000 0,0657643 0,08851911 ! peptide hormone secretion GO:0030072 32 19 0,000 0,0657643 0,08847037 ! protein secretion GO:0009306 45 20 0,000 0,06910414 0,09291218 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,06910414 0,09286107 ! positive regulation of ossification GO:0045778 50 20 0,000 0,06910414 0,09281002 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,06910414 0,09275902 ! skin development GO:0043588 42 20 0,000 0,06910414 0,09270809 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,06910414 0,0926572 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,06910414 0,09260638 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,06910414 0,09255561 ! response to vitamin GO:0033273 36 20 0,000 0,06910414 0,09250489 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,06910414 0,09245423 ! bile acid metabolic process GO:0008206 34 20 0,000 0,06910414 0,09240363 ! retinoid metabolic process GO:0001523 34 20 0,000 0,06910414 0,09235308 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,06910414 0,09230258 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,06910414 0,09225214 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,06910414 0,09220176 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,06910414 0,09215143 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,06910414 0,09210116 ! actin filament bundle formation GO:0051017 47 20 0,000 0,06910414 0,09205094 ! body fluid secretion GO:0007589 33 20 0,000 0,06910414 0,09200078 ! peptide secretion GO:0002790 38 20 0,000 0,06910414 0,09195067 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,06910414 0,09190061 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,06910414 0,09185061 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,06910414 0,09180067 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,06910414 0,09175077 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,06910414 0,09170094 ! cell-cell junction organization GO:0045216 43 20 0,000 0,06910414 0,09165115 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,06910414 0,09160142 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,06910414 0,09155175 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,06910414 0,09150213 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,06910414 0,09145256 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,06910414 0,09140305 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,06910414 0,09135358 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,06910414 0,09130418 ! negative regulation of translation GO:0017148 32 20 0,000 0,06910414 0,09125482 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,06910414 0,09120552 ! regulation of cell killing GO:0031341 46 21 0,000 0,07243214 0,09554629 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,07243214 0,09549472 ! hormone secretion GO:0046879 39 21 0,000 0,07243214 0,09544322 ! cAMP metabolic process GO:0046058 41 21 0,000 0,07243214 0,09539176 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,07243214 0,09534037 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,07243214 0,09528903 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,07243214 0,09523774 ! ovarian follicle development GO:0001541 39 21 0,000 0,07243214 0,09518651 ! smooth muscle contraction GO:0006939 48 21 0,000 0,07243214 0,09513533 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,07243214 0,09508421 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,07243214 0,09503315 ! plasma membrane fusion GO:0045026 33 21 0,000 0,07243214 0,09498214 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,07243214 0,09493118 ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,07243214 0,09488028 ! sensory perception of pain GO:0019233 33 21 0,000 0,07243214 0,09482943 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,07243214 0,09477864 ! diencephalon development GO:0021536 36 21 0,000 0,07243214 0,0947279 ! collagen fibril organization GO:0030199 62 21 0,000 0,07243214 0,09467722 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,07243214 0,09462659 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,07243214 0,09457601 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,07243214 0,09452549 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,07243214 0,09447502 ! collagen catabolic process GO:0030574 29 21 0,000 0,07243214 0,09442461 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,07243214 0,09437425 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,07243214 0,09432395 ! sperm-egg recognition GO:0035036 23 21 0,000 0,07243214 0,09427369 ! actin filament-based movement GO:0030048 47 21 0,000 0,07243214 0,09422349 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,07243214 0,09417335 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,07574833 0,09843254 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07574833 0,09838021 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,07574833 0,09832794 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07574833 0,09827572 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07574833 0,09822356 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,07574833 0,09817145 ! microtubule-based transport GO:0010970 59 22 0,000 0,07574833 0,0981194 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,07574833 0,0980674 ! cellular response to starvation GO:0009267 37 22 0,000 0,07574833 0,09801546 ! vacuolar transport GO:0007034 41 22 0,000 0,07574833 0,09796357 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07574833 0,09791174 ! fucose metabolic process GO:0006004 44 22 0,000 0,07574833 0,09785996 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07574833 0,09780823 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07574833 0,09775657 ! cell aging GO:0007569 48 22 0,000 0,07574833 0,09770495 ! stem cell differentiation GO:0048863 57 22 0,000 0,07574833 0,09765339 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07574833 0,09760189 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,07574833 0,09755044 ! cytolysis GO:0019835 27 22 0,000 0,07574833 0,09749904 ! renal system process GO:0003014 42 22 0,000 0,07574833 0,0974477 ! vasodilation GO:0042311 40 22 0,000 0,07574833 0,09739641 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07574833 0,09734518 ! G1 phase GO:0051318 44 22 0,000 0,07574833 0,097294 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,07574833 0,09724287 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,07574833 0,0971918 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,07574833 0,09714078 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,07574833 0,09708981 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07574833 0,0970389 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07574833 0,09698804 ! sarcomere organization GO:0045214 32 22 0,000 0,07574833 0,09693723 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,07574833 0,09688648 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07574833 0,09683578 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07574833 0,09678514 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07574833 0,09673454 ! gut development GO:0048565 44 22 0,000 0,07574833 0,096684 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07574833 0,09663351 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,07574833 0,09658308 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,07905276 0,10074382 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,07905276 0,10069129 ! gluconeogenesis GO:0006094 38 23 0,000 0,07905276 0,10063882 ! glycerol metabolic process GO:0006071 40 23 0,000 0,07905276 0,10058641 ! viral genome replication GO:0019079 44 23 0,000 0,07905276 0,10053405 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,07905276 0,10048174 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,07905276 0,10042949 ! regeneration GO:0031099 42 23 0,000 0,07905276 0,10037729 ! axis specification GO:0009798 43 23 0,000 0,07905276 0,10032514 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,07905276 0,10027305 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,07905276 0,10022102 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,07905276 0,10016904 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,07905276 0,10011711 ! peroxisome organization GO:0007031 43 23 0,000 0,07905276 0,10006523 ! lysosome organization GO:0007040 47 23 0,000 0,07905276 0,10001341 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,07905276 0,09996165 ! vesicle targeting GO:0006903 49 23 0,000 0,07905276 0,09990993 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,07905276 0,09985827 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,07905276 0,09980667 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,07905276 0,09975512 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,07905276 0,09970362 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,07905276 0,09965217 ! DNA modification GO:0006304 36 23 0,000 0,07905276 0,09960078 ! fatty acid transport GO:0015908 47 23 0,000 0,07905276 0,09954943 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,07905276 0,09949815 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,07905276 0,09944691 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,07905276 0,09939573 ! hormone transport GO:0009914 41 23 0,000 0,07905276 0,0993446 ! cell-cell recognition GO:0009988 28 23 0,000 0,07905276 0,09929352 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,07905276 0,0992425 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,07905276 0,09919153 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,08234547 0,10327002 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,08234547 0,10321703 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,08234547 0,1031641 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,08234547 0,10311122 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,08234547 0,1030584 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,08234547 0,10300563 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,08234547 0,10295291 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,08234547 0,10290025 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,08234547 0,10284764 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,08234547 0,10279509 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,08234547 0,10274259 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,08234547 0,10269014 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,08234547 0,10263775 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,08234547 0,10258541 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,08234547 0,10253312 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,08234547 0,10248089 ! oogenesis GO:0048477 44 24 0,000 0,08234547 0,10242871 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,08234547 0,10237659 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,08234547 0,10232451 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,08234547 0,10227249 ! platelet activation GO:0030168 41 24 0,000 0,08234547 0,10222052 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,08234547 0,10216861 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,08234547 0,10211675 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,08234547 0,10206494 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,08234547 0,10201318 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,08234547 0,10196147 ! regulation of amine transport GO:0051952 41 24 0,000 0,08234547 0,10190982 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,08234547 0,10185822 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,0856265 0,10586313 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,0856265 0,10580958 ! leukocyte adhesion GO:0007159 55 25 0,000 0,0856265 0,10575609 ! phototransduction GO:0007602 37 25 0,000 0,0856265 0,10570265 ! keratinization GO:0031424 37 25 0,000 0,0856265 0,10564926 ! vasculogenesis GO:0001570 49 25 0,000 0,0856265 0,10559593 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,0856265 0,10554265 ! vacuole organization GO:0007033 49 25 0,000 0,0856265 0,10548943 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,0856265 0,10543626 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,0856265 0,10538314 ! chromosome condensation GO:0030261 48 25 0,000 0,0856265 0,10533008 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,0856265 0,10527707 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,0856265 0,10522412 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,0856265 0,10517121 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,0856265 0,10511836 ! immunoglobulin production GO:0002377 62 25 0,000 0,0856265 0,10506557 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,0856265 0,10501282 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,0856265 0,10496013 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,0856265 0,10490749 ! liver development GO:0001889 55 25 0,000 0,0856265 0,10485491 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,08889589 0,10880394 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,08889589 0,10874945 ! molting cycle process GO:0022404 52 26 0,000 0,08889589 0,10869502 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,08889589 0,10864065 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,08889589 0,10858633 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,08889589 0,10853206 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,08889589 0,10847785 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,08889589 0,10842369 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,08889589 0,10836959 ! digestive system process GO:0022600 49 26 0,000 0,08889589 0,10831554 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,08889589 0,10826155 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,08889589 0,1082076 ! osteoblast differentiation GO:0001649 63 26 0,000 0,08889589 0,10815372 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,08889589 0,10809988 ! neural crest cell development GO:0014032 59 26 0,000 0,08889589 0,1080461 GO:0014033|neural crest cell differentiation, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,08889589 0,10799237 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,08889589 0,1079387 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,08889589 0,10788508 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,08889589 0,10783151 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,08889589 0,10777799 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,08889589 0,10772453 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,08889589 0,10767113 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,08889589 0,10761777 ! blastocyst development GO:0001824 50 26 0,000 0,08889589 0,10756447 ! telomere organization GO:0032200 46 26 0,000 0,08889589 0,10751122 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,08889589 0,10745802 ! alditol metabolic process GO:0019400 44 26 0,000 0,08889589 0,10740488 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,08889589 0,10735178 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,08889589 0,10729874 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,09215368 0,11117602 ! embryonic pattern specification GO:0009880 49 27 0,000 0,09215368 0,11112115 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,09215368 0,11106633 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,09215368 0,11101156 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,09215368 0,11095685 ! iron ion transport GO:0006826 65 27 0,000 0,09215368 0,11090219 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,09215368 0,11084758 ! superoxide metabolic process GO:0006801 41 27 0,000 0,09215368 0,11079303 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,09215368 0,11073854 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,09215368 0,11068409 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,09215368 0,1106297 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,09215368 0,11057537 ! response to starvation GO:0042594 47 27 0,000 0,09215368 0,11052108 ! response to toxin GO:0009636 49 27 0,000 0,09215368 0,11046685 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,09215368 0,11041267 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,09215368 0,11035855 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,09215368 0,11030448 ! leukocyte proliferation GO:0070661 59 27 0,000 0,09215368 0,11025046 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,09539991 0,11407831 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,09539991 0,1140225 ! vesicle docking GO:0048278 55 28 0,000 0,09539991 0,11396674 ! circadian rhythm GO:0007623 56 28 0,000 0,09539991 0,11391104 ! dendrite development GO:0016358 67 28 0,000 0,09539991 0,11385539 ! fat cell differentiation GO:0045444 57 28 0,000 0,09539991 0,1137998 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,09539991 0,11374426 ! sperm motility GO:0030317 37 28 0,000 0,09539991 0,11368878 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,09539991 0,11363335 ! base-excision repair GO:0006284 41 28 0,000 0,09539991 0,11357797 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,09539991 0,11352265 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,09539991 0,11346738 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,09539991 0,11341216 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,09539991 0,113357 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,09539991 0,11330189 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,09539991 0,11324684 ! glutathione metabolic process GO:0006749 42 28 0,000 0,09539991 0,11319184 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,09539991 0,11313689 ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,09539991 0,113082 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,09539991 0,11302715 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,09863463 0,11680291 ! translational initiation GO:0006413 66 29 0,000 0,09863463 0,11674632 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,09863463 0,11668978 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,09863463 0,1166333 ! autophagy GO:0006914 47 29 0,000 0,09863463 0,11657688 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,09863463 0,11652051 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,09863463 0,11646419 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,09863463 0,11640793 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,09863463 0,11635172 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,09863463 0,11629556 ! synaptogenesis GO:0007416 46 29 0,000 0,09863463 0,11623946 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,09863463 0,11618342 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,09863463 0,11612742 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,09863463 0,11607149 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,10185787 0,11980683 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,10185787 0,11974917 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,10185787 0,11969157 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,10185787 0,11963403 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,10185787 0,11957654 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,10185787 0,11951911 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,10185787 0,11946173 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,10185787 0,11940441 ! myofibril assembly GO:0030239 50 30 0,000 0,10185787 0,11934714 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,10185787 0,11928993 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,10185787 0,11923277 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,10185787 0,11917566 ! cell fate determination GO:0001709 64 30 0,000 0,10185787 0,11911861 ! phospholipid transport GO:0015914 65 30 0,000 0,10185787 0,11906162 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,10185787 0,11900468 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,10185787 0,11894779 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,10185787 0,11889096 ! tissue homeostasis GO:0001894 50 30 0,000 0,10185787 0,11883419 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,10185787 0,11877746 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10506968 0,12246432 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10506968 0,12240592 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10506968 0,12234758 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10506968 0,12228929 ! cell junction assembly GO:0034329 85 31 0,000 0,10506968 0,12223106 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10506968 0,12217288 ! ovulation cycle process GO:0022602 55 31 0,000 0,10506968 0,12211476 ! peptide transport GO:0015833 60 31 0,000 0,10506968 0,12205669 ! male gonad development GO:0008584 56 31 0,000 0,10506968 0,12199868 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,10506968 0,12194072 ! detection of light stimulus GO:0009583 44 31 0,000 0,10506968 0,12188282 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,10506968 0,12182498 ! natural killer cell activation GO:0030101 50 31 0,000 0,10506968 0,12176718 ! eye morphogenesis GO:0048592 65 31 0,000 0,10506968 0,12170945 ! response to heat GO:0009408 54 31 0,000 0,10506968 0,12165176 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,10506968 0,12159414 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,10827009 0,12523855 ! collagen metabolic process GO:0032963 49 32 0,000 0,10827009 0,12517928 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,10827009 0,12512007 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,10827009 0,12506091 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,10827009 0,12500181 ! muscle cell development GO:0055001 52 32 0,000 0,10827009 0,12494276 ! mesoderm formation GO:0001707 73 32 0,000 0,10827009 0,12488377 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,10827009 0,12482483 ! ovulation cycle GO:0042698 57 32 0,000 0,10827009 0,12476596 ! BMP signaling pathway GO:0030509 71 32 0,000 0,10827009 0,12470713 ! hindbrain development GO:0030902 65 32 0,000 0,10827009 0,12464836 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,10827009 0,12458965 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,10827009 0,12453099 ! gene silencing GO:0016458 71 32 0,000 0,10827009 0,12447239 ! regulation of pH GO:0006885 56 33 0,000 0,11145914 0,1280784 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,11145914 0,12801819 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,11145914 0,12795803 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,11145914 0,12789793 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,11145914 0,12783788 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,11145914 0,12777789 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,11145914 0,12771796 ! response to ionizing radiation GO:0010212 74 33 0,000 0,11145914 0,12765808 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,11145914 0,12759826 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,11145914 0,12753849 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,11145914 0,12747878 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,11145914 0,12741913 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,11145914 0,12735953 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,11463688 0,13092936 ! glial cell differentiation GO:0010001 67 34 0,000 0,11463688 0,13086818 ! post-embryonic development GO:0009791 76 34 0,000 0,11463688 0,13080705 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,11463688 0,13074599 ! cholesterol transport GO:0030301 62 34 0,000 0,11463688 0,13068497 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,11463688 0,13062402 ! spliceosome assembly GO:0000245 75 34 0,000 0,11463688 0,13056312 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,11463688 0,13050228 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,11463688 0,1304415 ! formation of primary germ layer GO:0001704 76 34 0,000 0,11463688 0,13038077 ! cell fate specification GO:0001708 56 34 0,000 0,11463688 0,1303201 ! adult locomotory behavior GO:0008344 62 34 0,000 0,11463688 0,13025949 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,11780334 0,13379524 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,11780334 0,13373307 ! negative regulation of secretion GO:0051048 68 35 0,000 0,11780334 0,13367096 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,11780334 0,1336089 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,11780334 0,1335469 ! membrane docking GO:0022406 69 35 0,000 0,11780334 0,13348496 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,11780334 0,13342307 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,11780334 0,13336125 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,11780334 0,13329948 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,11780334 0,13323776 ! ceramide metabolic process GO:0006672 72 35 0,000 0,11780334 0,13317611 ! sterol transport GO:0015918 63 35 0,000 0,11780334 0,13311451 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,11780334 0,13305297 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,11780334 0,13299148 ! placenta development GO:0001890 53 35 0,000 0,11780334 0,13293006 ! vesicle localization GO:0051648 70 35 0,000 0,11780334 0,13286868 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,12095857 0,13636446 ! positive regulation of cell development GO:0010720 85 36 0,000 0,12095857 0,13630156 ! protein targeting to membrane GO:0006612 75 36 0,000 0,12095857 0,13623872 ! regulation of proteolysis GO:0030162 77 36 0,000 0,12095857 0,13617594 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,12095857 0,13611322 ! cytokine production GO:0001816 68 36 0,000 0,12095857 0,13605055 ! embryonic organ development GO:0048568 67 36 0,000 0,12095857 0,13598794 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,12095857 0,13592539 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,12095857 0,13586289 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,1241026 0,13933027 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,1241026 0,13926627 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,1241026 0,13920232 ! odontogenesis GO:0042476 74 37 0,000 0,1241026 0,13913844 ! actomyosin structure organization GO:0031032 68 37 0,000 0,1241026 0,13907461 ! cell junction organization GO:0034330 96 37 0,000 0,1241026 0,13901085 ! tissue remodeling GO:0048771 78 37 0,000 0,1241026 0,13894714 ! female gonad development GO:0008585 71 37 0,000 0,1241026 0,13888349 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,1241026 0,1388199 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,1241026 0,13875637 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,1241026 0,13869289 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,12723548 0,14212907 ! organic anion transport GO:0015711 82 38 0,000 0,12723548 0,14206411 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,12723548 0,14199921 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,12723548 0,14193437 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,12723548 0,14186959 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,12723548 0,14180487 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,12723548 0,14174021 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,12723548 0,1416756 ! spermatid development GO:0007286 69 38 0,000 0,12723548 0,14161106 ! glycogen metabolic process GO:0005977 63 38 0,000 0,12723548 0,14154657 ! pigment metabolic process GO:0042440 87 38 0,000 0,12723548 0,14148214 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,13035723 0,1448875 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,13035723 0,14482161 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,13035723 0,14475578 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,13035723 0,14469002 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,13035723 0,14462431 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,13035723 0,14455866 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,13035723 0,14449307 ! glucan metabolic process GO:0044042 64 39 0,000 0,13035723 0,14442754 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,13346791 0,14780694 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,13346791 0,14773997 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,13346791 0,14767306 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,13346791 0,14760621 ! mismatch repair GO:0006298 58 40 0,000 0,13346791 0,14753942 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,13346791 0,14747269 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,13346791 0,14740602 ! RNA export from nucleus GO:0006405 61 41 0,000 0,13656755 0,1507612 ! mRNA catabolic process GO:0006402 79 41 0,000 0,13656755 0,1506931 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,13656755 0,15062507 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,13656755 0,1505571 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,13656755 0,15048919 ! gliogenesis GO:0042063 91 41 0,000 0,13656755 0,15042134 ! feeding behavior GO:0007631 69 41 0,000 0,13656755 0,15035355 ! mesenchymal cell development GO:0014031 94 41 0,000 0,13656755 0,15028582 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,13656755 0,15021816 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,13656755 0,15015055 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,13656755 0,15008301 ! RNA modification GO:0009451 64 41 0,000 0,13656755 0,15001553 ! organic ether metabolic process GO:0018904 59 42 0,000 0,13965619 0,15333936 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,13965619 0,15327047 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,13965619 0,15320165 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,13965619 0,15313289 ! regulation of protein secretion GO:0050708 77 42 0,000 0,13965619 0,15306419 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,13965619 0,15299555 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,13965619 0,15292697 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,14273387 0,15622708 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,14273387 0,15615711 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,14273387 0,15608721 ! regulation of tube size GO:0035150 76 43 0,000 0,14273387 0,15601738 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,14273387 0,1559476 ! glucose transport GO:0015758 66 43 0,000 0,14273387 0,15587789 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,14273387 0,15580824 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,14273387 0,15573865 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,14273387 0,15566912 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,14273387 0,15559966 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,14273387 0,15553026 ! ion transmembrane transport GO:0034220 79 43 0,000 0,14273387 0,15546092 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,14273387 0,15539164 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,14580062 0,15865965 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,14580062 0,15858901 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,14580062 0,15851843 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,14580062 0,15844791 ! hexose transport GO:0008645 68 44 0,000 0,14580062 0,15837746 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,14580062 0,15830707 ! striated muscle contraction GO:0006941 85 44 0,000 0,14580062 0,15823674 ! phagocytosis GO:0006909 105 44 0,000 0,14580062 0,15816648 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,14580062 0,15809628 ! double-strand break repair GO:0006302 85 44 0,000 0,14580062 0,15802614 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,14885649 0,1612667 ! keratinocyte differentiation GO:0030216 81 45 0,000 0,14885649 0,16119521 ! biopolymer methylation GO:0043414 91 45 0,000 0,14885649 0,16112379 ! B cell differentiation GO:0030183 124 45 0,000 0,14885649 0,16105244 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,14885649 0,16098114 ! female gamete generation GO:0007292 71 45 0,000 0,14885649 0,16090991 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,14885649 0,16083874 ! polyol metabolic process GO:0019751 77 45 0,000 0,14885649 0,16076764 ! developmental growth GO:0048589 88 45 0,000 0,14885649 0,1606966 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,15190151 0,16391139 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,15190151 0,16383902 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,15190151 0,16376672 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,15190151 0,16369448 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,15190151 0,1636223 ! cell growth GO:0016049 90 46 0,000 0,15190151 0,16355019 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,15493572 0,1667436 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,15795917 0,16992261 ! mitochondrial transport GO:0006839 94 48 0,000 0,15795917 0,16984782 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,15795917 0,16977309 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,15795917 0,16969844 ! male sex differentiation GO:0046661 93 48 0,000 0,15795917 0,16962384 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,15795917 0,16954932 ! methylation GO:0032259 97 48 0,000 0,15795917 0,16947485 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,16097188 0,17263138 ! protein homooligomerization GO:0051260 84 49 0,000 0,16097188 0,17255564 ! regulation of ion transport GO:0043269 86 50 0,000 0,16397389 0,17569659 ! endocrine system development GO:0035270 109 50 0,000 0,16397389 0,17561956 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,16397389 0,1755426 ! regulation of ossification GO:0030278 123 50 0,000 0,16397389 0,17546571 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,16397389 0,17538889 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,16397389 0,17531213 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,16397389 0,17523544 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,16397389 0,17515882 ! peptide metabolic process GO:0006518 80 51 0,000 0,16696525 0,17827627 ! response to temperature stimulus GO:0009266 84 51 0,000 0,16696525 0,17819839 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,16994599 0,18130046 ! Notch signaling pathway GO:0007219 111 52 0,000 0,16994599 0,18122133 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,16994599 0,18114226 ! excretion GO:0007588 87 52 0,000 0,16994599 0,18106326 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,16994599 0,18098433 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,16994599 0,18090547 ! amino acid activation GO:0043038 98 52 0,000 0,16994599 0,18082668 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! inner ear development GO:0048839 89 53 0,000 0,17291615 0,1839069 ! chromatin remodeling GO:0006338 122 53 0,000 0,17291615 0,18382687 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,17291615 0,18374691 ! vesicle organization GO:0016050 127 53 0,000 0,17291615 0,18366702 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,17291615 0,1835872 ! regulation of translational initiation GO:0006446 87 54 0,000 0,17587576 0,18664835 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,17587576 0,1865673 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,17587576 0,18648633 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 0,000 0,17587576 0,18640542 ! membrane fusion GO:0006944 122 54 0,000 0,17587576 0,18632458 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,17587576 0,18624382 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,17587576 0,18616313 ! RNA catabolic process GO:0006401 103 55 0,000 0,17882487 0,18920275 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,17882487 0,18912085 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,17882487 0,18903901 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,17882487 0,18895725 ! cell recognition GO:0008037 98 55 0,000 0,17882487 0,18887556 ! cell maturation GO:0048469 107 55 0,000 0,17882487 0,18879393 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,17882487 0,18871238 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,17882487 0,1886309 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,18176351 0,19164793 ! chloride transport GO:0006821 102 57 0,000 0,18469171 0,19465136 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,18469171 0,19456742 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,18469171 0,19448355 ! regulation of actin filament length GO:0030832 118 58 0,000 0,18760951 0,19747094 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,18760951 0,19738589 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,18760951 0,19730092 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,18760951 0,19721602 ! aging GO:0007568 112 58 0,000 0,18760951 0,1971312 ! gastrulation GO:0007369 122 58 0,000 0,18760951 0,19704645 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,18760951 0,19696177 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,18760951 0,19687717 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,18760951 0,19679263 ! nuclear export GO:0051168 110 59 0,000 0,19051696 0,19975662 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,19341408 0,20270725 ! regulation of endocytosis GO:0030100 104 60 0,000 0,19341408 0,20262032 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,19341408 0,20253348 ! adult behavior GO:0030534 104 60 0,000 0,19341408 0,2024467 ! positive regulation of secretion GO:0051047 110 61 0,000 0,19630091 0,20538036 ! regulation of cellular component size GO:0032535 125 61 0,000 0,19630091 0,20529244 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,19630091 0,20520459 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,19630091 0,20511682 ! camera-type eye development GO:0043010 126 61 0,000 0,19630091 0,20502913 ! proton transport GO:0015992 117 61 0,000 0,19630091 0,20494151 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,1991775 0,20785588 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,1991775 0,20776713 ! tRNA processing GO:0008033 102 62 0,000 0,1991775 0,20767846 ! mesoderm development GO:0007498 128 63 0,000 0,20204386 0,21057729 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,20204386 0,21048749 ! hydrogen transport GO:0006818 121 64 0,000 0,20490005 0,21337205 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,20490005 0,21328114 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,2077461 0,2161515 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,2077461 0,21605948 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,2077461 0,21596754 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,2077461 0,21587568 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,2077461 0,21578389 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,21058204 0,2186366 ! gonad development GO:0008406 115 66 0,000 0,21058204 0,21854372 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,21058204 0,21845092 ! secondary metabolic process GO:0019748 125 67 0,000 0,2134079 0,22128841 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,21622373 0,2241131 ! extracellular matrix organization GO:0030198 146 68 0,000 0,21622373 0,22401806 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,21622373 0,22392309 ! regulation of lipase activity GO:0060191 137 68 0,000 0,21622373 0,22382821 ! adaptive immune response GO:0002250 126 68 0,000 0,21622373 0,22373341 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,21902956 0,22654074 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,21902956 0,22644487 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,21902956 0,22634908 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,21902956 0,22625337 ! developmental maturation GO:0021700 128 69 0,000 0,21902956 0,22615774 ! single fertilization GO:0007338 83 69 0,000 0,21902956 0,2260622 ! cell redox homeostasis GO:0045454 114 70 0,000 0,22182542 0,22885115 ! germ cell development GO:0007281 133 70 0,000 0,22182542 0,22875454 ! activation of immune response GO:0002253 120 70 0,000 0,22182542 0,22865802 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,22182542 0,22856158 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,22461136 0,23133455 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,22461136 0,23123706 ! carbohydrate transport GO:0008643 114 72 0,000 0,22738739 0,23399638 ! B cell activation GO:0042113 179 72 0,000 0,22738739 0,23389785 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,22738739 0,23379941 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,22738739 0,23370105 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,22738739 0,23360278 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,22738739 0,23350458 ! humoral immune response GO:0006959 115 73 0,000 0,23015357 0,23624587 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,23015357 0,23614665 ! regulation of immune effector process GO:0002697 156 73 0,000 0,23015357 0,23604751 ! amino acid transport GO:0006865 148 74 0,000 0,23290992 0,23877421 ! transition metal ion transport GO:0000041 143 75 0,000 0,23565648 0,24148858 ! reproductive structure development GO:0048608 131 75 0,000 0,23565648 0,24138733 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,23565648 0,24128616 ! eye development GO:0001654 155 75 0,000 0,23565648 0,24118508 ! rhythmic process GO:0048511 142 75 0,000 0,23565648 0,24108408 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,23839328 0,24378183 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,23839328 0,24367983 ! regulation of blood pressure GO:0008217 134 76 0,000 0,23839328 0,24357791 ! amine catabolic process GO:0009310 136 77 0,000 0,24112036 0,2462613 ! neurotransmitter transport GO:0006836 142 77 0,000 0,24112036 0,2461584 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,24112036 0,24605557 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,24112036 0,24595284 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,24112036 0,24585018 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,24383775 0,24851716 ! antigen processing and presentation GO:0019882 117 78 0,000 0,24383775 0,24841352 ! fertilization GO:0009566 99 78 0,000 0,24383775 0,24830997 ! blood coagulation GO:0007596 151 79 0,000 0,24654549 0,25096276 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,24654549 0,25085824 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,24654549 0,2507538 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,24654549 0,25064945 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,24924361 0,25328708 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,24924361 0,25318176 ! muscle cell differentiation GO:0042692 178 81 0,000 0,25193214 0,2558064 ! protein import into nucleus GO:0006606 174 82 0,000 0,25461112 0,25841918 ! exocytosis GO:0006887 153 83 0,000 0,25728058 0,26102012 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,25728058 0,26091177 ! nuclear import GO:0051170 177 83 0,000 0,25728058 0,2608035 ! inorganic anion transport GO:0015698 156 83 0,000 0,25728058 0,26069533 ! response to nutrient GO:0007584 135 84 0,000 0,25994055 0,26328141 ! digestion GO:0007586 130 84 0,000 0,25994055 0,2631723 ! hemostasis GO:0007599 165 85 0,000 0,26259107 0,26574565 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,26259107 0,26563561 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,2678639 0,27085741 ! nucleosome assembly GO:0006334 126 87 0,000 0,2678639 0,27074535 ! sensory perception of smell GO:0007608 117 88 0,000 0,27048627 0,27328286 ! chromatin assembly GO:0031497 128 88 0,000 0,27048627 0,27316988 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,27048627 0,273057 ! cellular defense response GO:0006968 123 89 0,000 0,27309931 0,27558101 ! protein localization in nucleus GO:0034504 192 89 0,000 0,27309931 0,27546723 ! response to unfolded protein GO:0006986 139 90 0,000 0,27570308 0,27797879 ! ossification GO:0001503 205 91 0,000 0,27829758 0,28047896 ! defense response to bacterium GO:0042742 112 91 0,000 0,27829758 0,2803633 ! bone development GO:0060348 206 92 0,000 0,28088287 0,28285114 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,28088287 0,28273459 ! amine transport GO:0015837 181 93 0,000 0,28345897 0,28521016 ! vitamin metabolic process GO:0006766 153 93 0,000 0,28345897 0,28509274 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,28602591 0,28755609 ! female pregnancy GO:0007565 166 94 0,000 0,28602591 0,28743781 ! sterol metabolic process GO:0016125 166 94 0,000 0,28602591 0,28731962 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,28602591 0,28720152 ! nucleosome organization GO:0034728 143 95 0,000 0,28858373 0,28965081 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,28858373 0,28953185 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,28858373 0,289413 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,28858373 0,28929424 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,28858373 0,28917558 ! sex differentiation GO:0007548 171 96 0,000 0,29113246 0,29160992 ! response to protein stimulus GO:0051789 158 96 0,000 0,29113246 0,29149041 ! mRNA transport GO:0051028 185 100 0,000 0,3012371 0,30148391 ! positive regulation of immune response GO:0050778 175 100 0,000 0,3012371 0,30136046 ! hormone metabolic process GO:0042445 171 100 0,000 0,3012371 0,3012371