pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6725-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 7,000 2,205E-09 5,386E-06 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 7,000 2,483E-09 3,033E-06 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 7,000 3,509E-09 2,857E-06 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 7,000 3,509E-09 2,143E-06 ! positive regulation of ligase activity GO:0051351 130 77 7,000 6,036E-09 2,949E-06 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 7,000 7,42E-09 3,021E-06 ! regulation of ligase activity GO:0051340 147 84 7,000 1,213E-08 4,234E-06 ! neutrophil chemotaxis GO:0030593 29 17 4,000 1,908E-08 5,825E-06 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 7,000 2,726E-08 7,4E-06 GO:0010498|proteasomal protein catabolic process, ! positive regulation of endothelial cell migration GO:0010595 19 8 3,000 4,481E-08 1,095E-05 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 3,000 4,481E-08 9,952E-06 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 6,000 5,312E-08 1,081E-05 ! negative regulation of ligase activity GO:0051352 116 68 6,000 5,896E-08 1,108E-05 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of locomotion GO:0040017 44 22 4,000 7,952E-08 1,388E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! cell proliferation in forebrain GO:0021846 18 9 3,000 8,034E-08 1,308E-05 ! induction of positive chemotaxis GO:0050930 17 9 3,000 8,034E-08 1,227E-05 ! regulation of chemotaxis GO:0050920 45 23 4,000 1,012E-07 1,454E-05 ! regulation of behavior GO:0050795 48 25 4,000 1,585E-07 2,151E-05 ! positive regulation of cell cycle GO:0045787 96 48 5,000 1,649E-07 2,12E-05 ! myelination GO:0042552 50 26 4,000 1,954E-07 2,387E-05 ! response to hypoxia GO:0001666 178 81 6,000 2E-07 2,327E-05 ! response to oxygen levels GO:0070482 183 83 6,000 2,368E-07 2,63E-05 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 3,119E-07 3,313E-05 GO:0050927|positive regulation of positive chemotaxis, ! ensheathment of neurons GO:0007272 64 31 4,000 4,944E-07 5,032E-05 GO:0008366|axon ensheathment, ! positive regulation of MAP kinase activity GO:0043406 174 93 6,000 5,177E-07 5,059E-05 ! positive regulation of cell migration GO:0030335 137 58 5,000 5,213E-07 4,899E-05 ! leukocyte chemotaxis GO:0030595 55 33 4,000 6,849E-07 6,197E-05 GO:0060326|cell chemotaxis, ! negative regulation of response to stimulus GO:0048585 106 61 5,000 7,062E-07 6,162E-05 ! epithelial to mesenchymal transition GO:0001837 30 15 3,000 8,498E-07 7,159E-05 ! positive regulation of cell motion GO:0051272 157 65 5,000 1,033E-06 8,412E-05 ! ganglioside catabolic process GO:0006689 12 5 2,000 1,289E-06 1,016E-04 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 2,000 1,289E-06 9,841E-05 ! regulation of action potential in neuron GO:0019228 80 40 4,000 1,845E-06 1,366E-04 ! mesenchymal cell development GO:0014031 94 41 4,000 2,092E-06 1,503E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of endothelial cell migration GO:0010594 45 19 3,000 2,375E-06 1,658E-04 ! eye development GO:0001654 155 75 5,000 2,414E-06 1,638E-04 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 2,000 2,568E-06 1,696E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 2,995E-06 1,926E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 4,000 3,356E-06 2,102E-04 ! collagen fibril organization GO:0030199 62 21 3,000 3,638E-06 2,222E-04 ! leukocyte migration GO:0050900 75 46 4,000 3,749E-06 2,234E-04 ! positive regulation of phosphorylation GO:0042327 149 81 5,000 3,794E-06 2,207E-04 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 5,000 4,376E-06 2,486E-04 GO:0045937|positive regulation of phosphate metabolic process, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 2,000 4,478E-06 2,486E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 4,478E-06 2,431E-04 ! axonal fasciculation GO:0007413 19 7 2,000 4,478E-06 2,378E-04 ! negative regulation of transport GO:0051051 164 85 5,000 5,028E-06 2,613E-04 ! regulation of action potential GO:0001508 102 50 4,000 5,701E-06 2,901E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 3,000 6,382E-06 3,182E-04 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 4,000 6,935E-06 3,389E-04 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 2,000 7,138E-06 3,419E-04 ! glycolipid catabolic process GO:0019377 16 8 2,000 7,138E-06 3,353E-04 GO:0046479|glycosphingolipid catabolic process, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 7,138E-06 3,29E-04 ! neuromuscular process GO:0050905 107 54 4,000 8,37E-06 3,787E-04 ! regulation of blood coagulation GO:0030193 46 26 3,000 8,908E-06 3,957E-04 ! positive regulation of nuclear division GO:0051785 41 26 3,000 8,908E-06 3,886E-04 GO:0045840|positive regulation of mitosis, ! regulation of membrane potential GO:0042391 179 94 5,000 9,013E-06 3,863E-04 ! negative regulation of multicellular organismal process GO:0051241 174 95 5,000 9,58E-06 4,035E-04 ! RNA elongation GO:0006354 90 56 4,000 1,003E-05 4,152E-04 ! negative regulation of actin filament depolymerization GO:0030835 63 27 3,000 1,042E-05 4,241E-04 ! regulation of endothelial cell proliferation GO:0001936 60 27 3,000 1,042E-05 4,171E-04 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 2,000 1,067E-05 4,203E-04 GO:0010469|regulation of receptor activity, ! middle ear morphogenesis GO:0042474 14 9 2,000 1,067E-05 4,136E-04 ! ganglioside metabolic process GO:0001573 22 9 2,000 1,067E-05 4,072E-04 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 2,000 1,067E-05 4,009E-04 ! neuromuscular process controlling posture GO:0050884 15 9 2,000 1,067E-05 3,948E-04 ! transcription initiation GO:0006352 171 97 5,000 1,08E-05 3,938E-04 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 3,000 1,21E-05 4,348E-04 ! negative regulation of protein modification process GO:0031400 66 28 3,000 1,21E-05 4,285E-04 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 2,000 1,518E-05 5,298E-04 ! positive regulation of heart contraction GO:0045823 17 10 2,000 1,518E-05 5,223E-04 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 1,518E-05 5,151E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 1,518E-05 5,08E-04 ! regulation of heart contraction GO:0008016 123 61 4,000 1,53E-05 5,05E-04 ! regulation of actin filament depolymerization GO:0030834 67 30 3,000 1,607E-05 5,235E-04 ! regulation of coagulation GO:0050818 52 30 3,000 1,607E-05 5,166E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 2,000 2,08E-05 6,598E-04 ! detection of mechanical stimulus GO:0050982 22 11 2,000 2,08E-05 6,513E-04 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 2,08E-05 6,431E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 2,08E-05 6,35E-04 ! positive regulation of leukocyte migration GO:0002687 28 11 2,000 2,08E-05 6,272E-04 ! negative regulation of glucose import GO:0046325 18 11 2,000 2,08E-05 6,195E-04 GO:0010829|negative regulation of glucose transport, ! prepulse inhibition GO:0060134 18 11 2,000 2,08E-05 6,121E-04 ! regulation of leukocyte migration GO:0002685 29 12 2,000 2,762E-05 8,034E-04 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 2,000 2,762E-05 7,939E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 4,000 2,796E-05 7,944E-04 ! plasma membrane organization GO:0007009 27 13 2,000 3,578E-05 1,005E-03 ! regulation of RNA splicing GO:0043484 22 13 2,000 3,578E-05 9,932E-04 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 2,000 3,578E-05 9,82E-04 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 3,000 3,767E-05 1,023E-03 ! regulation of actin cytoskeleton organization GO:0032956 167 76 4,000 4,467E-05 1,199E-03 ! lipid localization GO:0010876 32 14 2,000 4,536E-05 1,205E-03 GO:0019915|lipid storage, ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 4,536E-05 1,192E-03 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 3,000 4,654E-05 1,21E-03 ! regulation of actin filament-based process GO:0032970 170 79 4,000 5,382E-05 1,384E-03 ! regulation of mRNA processing GO:0050684 26 15 2,000 5,649E-05 1,438E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 5,649E-05 1,423E-03 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 4,000 6,069E-05 1,513E-03 ! positive regulation of cell size GO:0045793 29 16 2,000 6,926E-05 1,709E-03 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 2,000 6,926E-05 1,692E-03 ! startle response GO:0001964 28 16 2,000 6,926E-05 1,675E-03 ! neuron recognition GO:0008038 40 16 2,000 6,926E-05 1,659E-03 ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 6,926E-05 1,643E-03 ! negative regulation of protein complex disassembly GO:0043242 113 44 3,000 7,53E-05 1,769E-03 ! regulation of neuron differentiation GO:0045664 187 85 4,000 7,643E-05 1,778E-03 ! branching morphogenesis of a tube GO:0048754 102 45 3,000 8,232E-05 1,897E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 8,232E-05 1,88E-03 ! negative regulation of blood coagulation GO:0030195 25 17 2,000 8,379E-05 1,895E-03 ! adult walking behavior GO:0007628 36 18 2,000 1,002E-04 2,245E-03 ! patterning of blood vessels GO:0001569 43 18 2,000 1,002E-04 2,225E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 1,002E-04 2,205E-03 ! sphingolipid catabolic process GO:0030149 32 18 2,000 1,002E-04 2,185E-03 GO:0046466|membrane lipid catabolic process, ! regulation of cell morphogenesis GO:0022604 243 93 4,000 1,172E-04 2,533E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 1,348E-04 2,889E-03 ! actin filament bundle formation GO:0051017 47 20 2,000 1,389E-04 2,951E-03 ! regulation of glucose import GO:0046324 30 20 2,000 1,389E-04 2,925E-03 GO:0010827|regulation of glucose transport, ! negative regulation of coagulation GO:0050819 30 20 2,000 1,389E-04 2,9E-03 ! regulation of protein complex disassembly GO:0043244 127 52 3,000 1,455E-04 3,012E-03 ! morphogenesis of a branching structure GO:0001763 116 52 3,000 1,455E-04 2,987E-03 ! forebrain development GO:0030900 210 98 4,000 1,5E-04 3,054E-03 ! cartilage development GO:0051216 99 53 3,000 1,567E-04 3,165E-03 ! phosphatidylinositol metabolic process GO:0046488 47 21 2,000 1,614E-04 3,233E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 1,614E-04 3,207E-03 ! regulation of vasoconstriction GO:0019229 40 21 2,000 1,614E-04 3,181E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 1,614E-04 3,155E-03 ! regulation of angiogenesis GO:0045765 125 54 3,000 1,686E-04 3,269E-03 ! regulation of muscle contraction GO:0006937 94 54 3,000 1,686E-04 3,243E-03 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 3,000 1,811E-04 3,457E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 1,862E-04 3,527E-03 ! negative regulation of cytoskeleton organization GO:0051494 139 56 3,000 1,943E-04 3,651E-03 ! lysosome organization GO:0007040 47 23 2,000 2,134E-04 3,979E-03 ! regulation of actin filament length GO:0030832 118 58 3,000 2,226E-04 4,121E-03 ! positive regulation of organelle organization GO:0010638 108 58 3,000 2,226E-04 4,09E-03 ! positive regulation of cell adhesion GO:0045785 61 24 2,000 2,429E-04 4,429E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 2,429E-04 4,396E-03 ! calcium-independent cell-cell adhesion GO:0016338 36 24 2,000 2,429E-04 4,364E-03 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 2,429E-04 4,332E-03 ! glycosphingolipid metabolic process GO:0006687 44 24 2,000 2,429E-04 4,301E-03 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 1,000 2,553E-04 4,487E-03 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,553E-04 4,455E-03 ! hypothalamus development GO:0021854 9 5 1,000 2,553E-04 4,423E-03 ! cell migration involved in gastrulation GO:0042074 7 5 1,000 2,553E-04 4,392E-03 ! apoptotic cell clearance GO:0043277 23 5 1,000 2,553E-04 4,362E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,553E-04 4,331E-03 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 1,000 2,553E-04 4,301E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 2,553E-04 4,272E-03 ! microvillus organization GO:0032528 8 5 1,000 2,553E-04 4,243E-03 GO:0030033|microvillus assembly, ! mRNA transcription GO:0009299 10 5 1,000 2,553E-04 4,214E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 2,553E-04 4,186E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,553E-04 4,158E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 2,553E-04 4,13E-03 ! muscle cell proliferation GO:0033002 12 5 1,000 2,553E-04 4,103E-03 ! positive regulation of blood coagulation GO:0030194 12 5 1,000 2,553E-04 4,076E-03 ! positive regulation of macrophage activation GO:0043032 12 5 1,000 2,553E-04 4,05E-03 ! regulation of hair follicle development GO:0051797 10 5 1,000 2,553E-04 4,024E-03 GO:0042634|regulation of hair cycle, ! glial cell migration GO:0008347 10 5 1,000 2,553E-04 3,998E-03 ! negative regulation of fibrinolysis GO:0051918 11 5 1,000 2,553E-04 3,973E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 2,553E-04 3,947E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 2,553E-04 3,923E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 2,553E-04 3,898E-03 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 1,000 2,553E-04 3,874E-03 ! regulation of cellular component size GO:0032535 125 61 3,000 2,706E-04 4,081E-03 ! vasculogenesis GO:0001570 49 25 2,000 2,75E-04 4,122E-03 ! vacuole organization GO:0007033 49 25 2,000 2,75E-04 4,097E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 2,881E-04 4,266E-03 ! regulation of mitosis GO:0007088 112 63 3,000 3,065E-04 4,51E-03 GO:0051783|regulation of nuclear division, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 3,098E-04 4,531E-03 GO:0045936|negative regulation of phosphate metabolic process, ! insulin receptor signaling pathway GO:0008286 66 27 2,000 3,472E-04 5,048E-03 ! ear development GO:0043583 114 66 3,000 3,664E-04 5,297E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 3,817E-04 5,485E-03 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 1,000 3,817E-04 5,453E-03 ! vascular smooth muscle contraction GO:0014829 13 6 1,000 3,817E-04 5,421E-03 ! positive regulation of muscle hypertrophy GO:0014742 10 6 1,000 3,817E-04 5,39E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! neural nucleus development GO:0048857 19 6 1,000 3,817E-04 5,359E-03 ! astrocyte development GO:0014002 16 6 1,000 3,817E-04 5,328E-03 ! Schwann cell development GO:0014044 15 6 1,000 3,817E-04 5,298E-03 ! receptor internalization GO:0031623 11 6 1,000 3,817E-04 5,268E-03 ! salivary gland morphogenesis GO:0007435 14 6 1,000 3,817E-04 5,238E-03 ! progesterone metabolic process GO:0042448 12 6 1,000 3,817E-04 5,209E-03 ! negative regulation of axon extension GO:0030517 24 6 1,000 3,817E-04 5,18E-03 ! positive regulation of coagulation GO:0050820 13 6 1,000 3,817E-04 5,151E-03 ! glycolipid metabolic process GO:0006664 50 28 2,000 3,874E-04 5,2E-03 ! activation of MAPK activity GO:0000187 124 67 3,000 3,882E-04 5,182E-03 ! extracellular matrix organization GO:0030198 146 68 3,000 4,108E-04 5,454E-03 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 2,000 4,305E-04 5,684E-03 ! neuromuscular process controlling balance GO:0050885 67 29 2,000 4,305E-04 5,654E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 4,343E-04 5,674E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 4,588E-04 5,963E-03 ! eye morphogenesis GO:0048592 65 31 2,000 5,256E-04 6,794E-03 ! negative regulation of cellular catabolic process GO:0031330 12 7 1,000 5,325E-04 6,847E-03 ! neuron adhesion GO:0007158 14 7 1,000 5,325E-04 6,812E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 5,325E-04 6,776E-03 ! mRNA stabilization GO:0048255 18 7 1,000 5,325E-04 6,741E-03 GO:0043489|RNA stabilization, ! fibril organization GO:0043206 17 7 1,000 5,325E-04 6,706E-03 ! positive regulation of heart rate GO:0010460 11 7 1,000 5,325E-04 6,672E-03 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 1,000 5,325E-04 6,638E-03 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 1,000 5,325E-04 6,604E-03 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 1,000 5,325E-04 6,571E-03 ! regulation of granule cell precursor proliferation GO:0021936 12 7 1,000 5,325E-04 6,538E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! phasic smooth muscle contraction GO:0014821 12 7 1,000 5,325E-04 6,505E-03 ! melanosome organization GO:0032438 10 7 1,000 5,325E-04 6,473E-03 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 5,325E-04 6,441E-03 ! fibrinolysis GO:0042730 11 7 1,000 5,325E-04 6,409E-03 ! negative regulation of focal adhesion formation GO:0051895 21 7 1,000 5,325E-04 6,377E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 5,325E-04 6,346E-03 ! regulation of lipid transport GO:0032368 14 7 1,000 5,325E-04 6,316E-03 ! diuresis GO:0030146 12 7 1,000 5,325E-04 6,285E-03 GO:0030147|natriuresis, ! dopamine biosynthetic process GO:0042416 18 7 1,000 5,325E-04 6,255E-03 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 1,000 5,325E-04 6,225E-03 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 1,000 5,325E-04 6,195E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 5,668E-04 6,562E-03 ! response to mechanical stimulus GO:0009612 60 32 2,000 5,778E-04 6,658E-03 ! peripheral nervous system development GO:0007422 68 32 2,000 5,778E-04 6,627E-03 ! hindbrain development GO:0030902 65 32 2,000 5,778E-04 6,596E-03 ! axon guidance GO:0007411 162 75 3,000 5,964E-04 6,776E-03 ! negative regulation of response to external stimulus GO:0032102 50 33 2,000 6,332E-04 7,162E-03 ! regulation of axonogenesis GO:0050770 86 33 2,000 6,332E-04 7,129E-03 ! phosphoinositide metabolic process GO:0030384 146 77 3,000 6,588E-04 7,382E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 6,919E-04 7,718E-03 ! adult locomotory behavior GO:0008344 62 34 2,000 6,919E-04 7,683E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 7,077E-04 7,823E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 7,077E-04 7,788E-03 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 7,077E-04 7,753E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 7,077E-04 7,718E-03 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 7,077E-04 7,684E-03 ! pigment granule organization GO:0048753 17 8 1,000 7,077E-04 7,65E-03 ! astrocyte differentiation GO:0048708 19 8 1,000 7,077E-04 7,616E-03 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 1,000 7,077E-04 7,583E-03 ! regulation of muscle hypertrophy GO:0014743 12 8 1,000 7,077E-04 7,55E-03 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! regulation of vascular permeability GO:0043114 12 8 1,000 7,077E-04 7,517E-03 ! Schwann cell differentiation GO:0014037 21 8 1,000 7,077E-04 7,484E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 7,077E-04 7,452E-03 ! regulation of focal adhesion formation GO:0051893 23 8 1,000 7,077E-04 7,42E-03 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 7,077E-04 7,388E-03 ! positive regulation of epidermis development GO:0045684 13 8 1,000 7,077E-04 7,357E-03 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 7,077E-04 7,326E-03 GO:0002688|regulation of leukocyte chemotaxis, ! negative regulation of organic acid transport GO:0032891 13 8 1,000 7,077E-04 7,295E-03 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 1,000 7,077E-04 7,264E-03 ! positive regulation of smooth muscle contraction GO:0045987 15 8 1,000 7,077E-04 7,234E-03 ! regulation of synaptic transmission GO:0050804 159 79 3,000 7,256E-04 7,386E-03 ! negative regulation of secretion GO:0051048 68 35 2,000 7,539E-04 7,643E-03 ! regulation of synaptic plasticity GO:0048167 78 35 2,000 7,539E-04 7,611E-03 ! ceramide metabolic process GO:0006672 72 35 2,000 7,539E-04 7,58E-03 ! calcium-mediated signaling GO:0019722 67 35 2,000 7,539E-04 7,549E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 3,000 7,608E-04 7,587E-03 ! activation of protein kinase activity GO:0032147 170 80 3,000 7,608E-04 7,556E-03 ! negative regulation of organelle organization GO:0010639 181 80 3,000 7,608E-04 7,525E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 8,884E-04 8,751E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 9,068E-04 8,897E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 9,068E-04 8,861E-03 ! cerebral cortex cell migration GO:0021795 18 9 1,000 9,068E-04 8,826E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 9,068E-04 8,791E-03 ! establishment of melanosome localization GO:0032401 14 9 1,000 9,068E-04 8,756E-03 ! renal water homeostasis GO:0003091 15 9 1,000 9,068E-04 8,722E-03 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 1,000 9,068E-04 8,688E-03 ! regulation of macrophage activation GO:0043030 17 9 1,000 9,068E-04 8,654E-03 ! regulation of telomere maintenance GO:0032204 17 9 1,000 9,068E-04 8,62E-03 ! regulation of muscle adaptation GO:0043502 14 9 1,000 9,068E-04 8,587E-03 ! regulation of transmission of nerve impulse GO:0051969 167 85 3,000 9,55E-04 9,008E-03 ! sphingoid metabolic process GO:0046519 78 38 2,000 9,609E-04 9,029E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 9,609E-04 8,995E-03 ! regulation of neuron projection development GO:0010975 102 39 2,000 1,037E-03 9,671E-03 ! regulation of phosphatase activity GO:0010921 28 10 1,000 1,13E-03 0,01049403 ! SMAD protein nuclear translocation GO:0007184 21 10 1,000 1,13E-03 0,01045428 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 1,13E-03 0,01041483 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 1,000 1,13E-03 0,01037568 ! lung alveolus development GO:0048286 26 10 1,000 1,13E-03 0,01033682 ! phagocytosis, engulfment GO:0006911 33 10 1,000 1,13E-03 0,01029825 ! ruffle organization GO:0031529 17 10 1,000 1,13E-03 0,01025997 ! lens development in camera-type eye GO:0002088 17 10 1,000 1,13E-03 0,01022197 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 1,13E-03 0,01018425 ! motor axon guidance GO:0008045 22 10 1,000 1,13E-03 0,0101468 ! regulation of bone resorption GO:0045124 25 10 1,000 1,13E-03 0,01010964 ! melanosome localization GO:0032400 16 10 1,000 1,13E-03 0,01007274 ! salivary gland development GO:0007431 28 10 1,000 1,13E-03 0,01003611 ! midbrain development GO:0030901 14 10 1,000 1,13E-03 1E-02 ! multicellular organismal water homeostasis GO:0050891 16 10 1,000 1,13E-03 9,964E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,13E-03 9,928E-03 GO:0043470|regulation of carbohydrate catabolic process, ! establishment of pigment granule localization GO:0051905 18 10 1,000 1,13E-03 9,892E-03 ! regulation of fibrinolysis GO:0051917 20 10 1,000 1,13E-03 9,857E-03 ! tube morphogenesis GO:0035239 194 89 3,000 1,134E-03 9,855E-03 ! regulation of neurological system process GO:0031644 175 89 3,000 1,134E-03 9,82E-03 ! regulation of cell cycle process GO:0010564 161 90 3,000 1,182E-03 0,01020059 ! gliogenesis GO:0042063 91 41 2,000 1,201E-03 0,01032915 ! gland development GO:0048732 220 91 3,000 1,231E-03 0,01055304 ! regulation of cell adhesion GO:0030155 241 92 3,000 1,282E-03 0,01095092 ! ear morphogenesis GO:0042471 64 42 2,000 1,288E-03 0,01096644 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 1,288E-03 0,01092837 ! telencephalon cell migration GO:0022029 23 11 1,000 1,376E-03 0,01163308 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,376E-03 0,01159296 ! blood vessel remodeling GO:0001974 30 11 1,000 1,376E-03 0,01155313 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,376E-03 0,01151356 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,376E-03 0,01147426 ! negative regulation of proteolysis GO:0045861 25 11 1,000 1,376E-03 0,01143524 ! positive regulation of muscle contraction GO:0045933 19 11 1,000 1,376E-03 0,01139647 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 1,376E-03 0,01135797 ! negative regulation of axonogenesis GO:0050771 37 11 1,000 1,376E-03 0,01131973 ! pigment granule localization GO:0051875 20 11 1,000 1,376E-03 0,01128174 ! vasoconstriction GO:0042310 20 11 1,000 1,376E-03 0,01124401 ! apical protein localization GO:0045176 18 11 1,000 1,376E-03 0,01120653 ! regulation of organic acid transport GO:0032890 19 11 1,000 1,376E-03 0,0111693 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 1,38E-03 0,01116168 ! glucose transport GO:0015758 66 43 2,000 1,38E-03 0,01112485 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 2,000 1,475E-03 0,01185531 ! hexose transport GO:0008645 68 44 2,000 1,475E-03 0,01181644 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 2,000 1,475E-03 0,01177782 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,646E-03 0,01309725 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,646E-03 0,01305472 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 1,000 1,646E-03 0,01301248 ! negative regulation of endothelial cell migration GO:0010596 26 12 1,000 1,646E-03 0,0129705 ! forebrain cell migration GO:0021885 24 12 1,000 1,646E-03 0,01292879 ! regulation of interleukin-12 production GO:0032655 19 12 1,000 1,646E-03 0,01288736 ! cranial nerve development GO:0021545 23 12 1,000 1,646E-03 0,01284618 ! histone acetylation GO:0016573 27 12 1,000 1,646E-03 0,01280527 ! autonomic nervous system development GO:0048483 24 12 1,000 1,646E-03 0,01276462 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 1,646E-03 0,01272422 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,646E-03 0,01268408 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 1,646E-03 0,0126442 GO:0042130|negative regulation of T cell proliferation, ! embryonic placenta development GO:0001892 21 12 1,000 1,646E-03 0,01260456 ! localization within membrane GO:0051668 26 12 1,000 1,646E-03 0,01256517 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 1,678E-03 0,01277312 ! negative regulation of cell migration GO:0030336 122 46 2,000 1,678E-03 0,01273345 ! pigmentation GO:0043473 103 46 2,000 1,678E-03 0,01269403 ! response to insulin stimulus GO:0032868 98 47 2,000 1,786E-03 0,01346742 ! positive regulation of defense response GO:0031349 88 48 2,000 1,898E-03 0,0142678 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 2,000 1,898E-03 0,01422404 ! vascular process in circulatory system GO:0003018 85 48 2,000 1,898E-03 0,01418054 ! regulation of inflammatory response GO:0050727 84 48 2,000 1,898E-03 0,01413731 ! negative regulation of cell projection organization GO:0031345 42 13 1,000 1,939E-03 0,01439522 ! positive regulation of cell growth GO:0030307 24 13 1,000 1,939E-03 0,0143516 ! exocrine system development GO:0035272 34 13 1,000 1,939E-03 0,01430824 ! asymmetric protein localization GO:0008105 24 13 1,000 1,939E-03 0,01426515 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 1,939E-03 0,01422231 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,939E-03 0,01417973 ! gastrulation with mouth forming second GO:0001702 29 13 1,000 1,939E-03 0,0141374 ! gland morphogenesis GO:0022612 31 13 1,000 1,939E-03 0,01409532 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 1,939E-03 0,0140535 ! regulation of epidermis development GO:0045682 19 13 1,000 1,939E-03 0,01401192 ! regulation of mRNA stability GO:0043488 32 13 1,000 1,939E-03 0,01397059 ! detection of stimulus involved in sensory perception GO:0050906 75 49 2,000 2,014E-03 0,0144738 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 2,135E-03 0,01529546 ! positive regulation of cytokine production GO:0001819 94 50 2,000 2,135E-03 0,01525074 ! hair follicle morphogenesis GO:0031069 27 14 1,000 2,254E-03 0,01605509 ! regulation of heart rate GO:0002027 25 14 1,000 2,254E-03 0,01600842 ! catecholamine biosynthetic process GO:0042423 30 14 1,000 2,254E-03 0,01596202 ! regulation of RNA stability GO:0043487 33 14 1,000 2,254E-03 0,01591589 ! regulation of axon extension GO:0030516 43 14 1,000 2,254E-03 0,01587002 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 2,254E-03 0,01582442 ! regulation of cell projection organization GO:0031344 135 51 2,000 2,26E-03 0,01581992 ! detection of abiotic stimulus GO:0009582 80 51 2,000 2,26E-03 0,01577472 ! positive regulation of growth GO:0045927 96 53 2,000 2,523E-03 0,01756322 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 2,523E-03 0,01751332 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,592E-03 0,01794017 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 2,592E-03 0,01788949 ! response to hexose stimulus GO:0009746 25 15 1,000 2,592E-03 0,0178391 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! water homeostasis GO:0030104 28 15 1,000 2,592E-03 0,01778899 ! dopamine metabolic process GO:0042417 35 15 1,000 2,592E-03 0,01773916 ! cAMP biosynthetic process GO:0006171 25 15 1,000 2,592E-03 0,01768961 ! activation of phospholipase C activity GO:0007202 110 54 2,000 2,662E-03 0,01811445 GO:0010863|positive regulation of phospholipase C activity, ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 2,000 2,662E-03 0,01806413 ! positive regulation of phospholipase activity GO:0010518 111 55 2,000 2,805E-03 0,01898266 ! cell recognition GO:0008037 98 55 2,000 2,805E-03 0,01893022 ! negative regulation of cell motion GO:0051271 142 55 2,000 2,805E-03 0,01887807 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,953E-03 0,01981705 ! pituitary gland development GO:0021983 30 16 1,000 2,953E-03 0,01976275 ! regulation of dephosphorylation GO:0035303 43 16 1,000 2,953E-03 0,01970876 ! negative regulation of immune response GO:0050777 38 16 1,000 2,953E-03 0,01965505 ! embryonic digit morphogenesis GO:0042733 36 16 1,000 2,953E-03 0,01960164 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 2,953E-03 0,01954852 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 2,953E-03 0,01949569 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 1,000 2,953E-03 0,01944314 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 2,953E-03 0,01939087 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 3,105E-03 0,02033856 ! regulation of bone remodeling GO:0046850 143 57 2,000 3,105E-03 0,02028418 ! regulation of phospholipase activity GO:0010517 113 57 2,000 3,105E-03 0,02023009 ! regulation of tissue remodeling GO:0034103 146 58 2,000 3,263E-03 0,02119791 ! positive regulation of lipase activity GO:0060193 115 58 2,000 3,263E-03 0,02114168 ! negative regulation of hormone secretion GO:0046888 26 17 1,000 3,335E-03 0,02155529 ! endothelial cell migration GO:0043542 31 17 1,000 3,335E-03 0,02149841 ! glial cell development GO:0021782 28 17 1,000 3,335E-03 0,02144184 ! regulation of muscle cell differentiation GO:0051147 36 17 1,000 3,335E-03 0,02138556 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 3,335E-03 0,02132958 ! activation of MAPKK activity GO:0000186 43 17 1,000 3,335E-03 0,02127389 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 3,335E-03 0,02121848 ! regulation of survival gene product expression GO:0045884 38 17 1,000 3,335E-03 0,02116337 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 3,335E-03 0,02110854 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 3,335E-03 0,021054 ! adult behavior GO:0030534 104 60 2,000 3,591E-03 0,02261328 ! limbic system development GO:0021761 40 18 1,000 3,74E-03 0,02348533 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 3,74E-03 0,02342511 GO:0050886|endocrine process, ! epidermis morphogenesis GO:0048730 43 18 1,000 3,74E-03 0,0233652 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 3,74E-03 0,0233056 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 1,000 3,74E-03 0,0232463 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 3,74E-03 0,0231873 ! nerve development GO:0021675 34 18 1,000 3,74E-03 0,02312859 ! glycosaminoglycan metabolic process GO:0030203 108 61 2,000 3,763E-03 0,02321611 ! camera-type eye development GO:0043010 126 61 2,000 3,763E-03 0,02315763 ! skeletal system morphogenesis GO:0048705 118 63 2,000 4,122E-03 0,02529921 ! positive regulation of translation GO:0045727 31 19 1,000 4,166E-03 0,02550509 ! positive regulation of hormone secretion GO:0046887 35 19 1,000 4,166E-03 0,02544133 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 4,166E-03 0,02537789 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 4,166E-03 0,02531476 ! cerebral cortex development GO:0021987 40 19 1,000 4,166E-03 0,02525194 ! neuromuscular junction development GO:0007528 43 19 1,000 4,166E-03 0,02518944 ! peptide cross-linking GO:0018149 39 19 1,000 4,166E-03 0,02512724 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 1,000 4,166E-03 0,02506535 ! cellular pigmentation GO:0033059 37 19 1,000 4,166E-03 0,02500377 ! peptide hormone secretion GO:0030072 32 19 1,000 4,166E-03 0,02494248 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 4,308E-03 0,02573391 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 4,308E-03 0,02567114 ! sphingolipid metabolic process GO:0006665 122 65 2,000 4,5E-03 0,02674842 ! positive regulation of ossification GO:0045778 50 20 1,000 4,613E-03 0,02735329 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 4,613E-03 0,02728705 ! skin development GO:0043588 42 20 1,000 4,613E-03 0,02722114 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 4,613E-03 0,02715555 ! protein amino acid acetylation GO:0006473 41 20 1,000 4,613E-03 0,02709027 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 4,613E-03 0,02702531 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 4,613E-03 0,02696065 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 1,000 4,613E-03 0,02689631 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 4,613E-03 0,02683227 ! response to carbohydrate stimulus GO:0009743 33 20 1,000 4,613E-03 0,02676854 ! body fluid secretion GO:0007589 33 20 1,000 4,613E-03 0,0267051 ! peptide secretion GO:0002790 38 20 1,000 4,613E-03 0,02664197 ! cell-cell junction organization GO:0045216 43 20 1,000 4,613E-03 0,02657914 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 4,613E-03 0,0265166 ! negative regulation of T cell activation GO:0050868 41 20 1,000 4,613E-03 0,02645435 ! negative regulation of translation GO:0017148 32 20 1,000 4,613E-03 0,0263924 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 4,697E-03 0,02680952 ! embryonic limb morphogenesis GO:0030326 139 67 2,000 4,899E-03 0,02789719 GO:0035113|embryonic appendage morphogenesis, ! hormone secretion GO:0046879 39 21 1,000 5,082E-03 0,02887048 ! lipid phosphorylation GO:0046834 43 21 1,000 5,082E-03 0,02880349 ! cAMP metabolic process GO:0046058 41 21 1,000 5,082E-03 0,02873682 ! C21-steroid hormone metabolic process GO:0008207 38 21 1,000 5,082E-03 0,02867045 ! smooth muscle contraction GO:0006939 48 21 1,000 5,082E-03 0,02860439 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 5,082E-03 0,02853863 ! diencephalon development GO:0021536 36 21 1,000 5,082E-03 0,02847318 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 5,082E-03 0,02840802 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 5,082E-03 0,02834316 ! regulation of cellular response to stress GO:0080135 142 68 2,000 5,106E-03 0,02841444 ! detection of external stimulus GO:0009581 102 68 2,000 5,106E-03 0,02834986 ! regulation of lipase activity GO:0060191 137 68 2,000 5,106E-03 0,02828558 ! lung development GO:0030324 165 69 2,000 5,318E-03 0,02939526 ! positive regulation of bone remodeling GO:0046852 54 22 1,000 5,571E-03 0,03072288 GO:0034105|positive regulation of tissue remodeling, ! glutamate signaling pathway GO:0007215 48 22 1,000 5,571E-03 0,03065369 ! apoptotic nuclear changes GO:0030262 34 22 1,000 5,571E-03 0,0305848 ! renal system process GO:0003014 42 22 1,000 5,571E-03 0,03051623 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 5,571E-03 0,03044796 ! aminoglycan metabolic process GO:0006022 121 71 2,000 5,759E-03 0,03140343 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 5,759E-03 0,03133349 ! appendage morphogenesis GO:0035107 150 72 2,000 5,987E-03 0,03250259 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 2,000 5,987E-03 0,03243052 ! respiratory tube development GO:0030323 171 72 2,000 5,987E-03 0,03235877 ! actin filament organization GO:0007015 167 72 2,000 5,987E-03 0,03228734 ! membrane lipid metabolic process GO:0006643 132 72 2,000 5,987E-03 0,03221622 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 5,987E-03 0,03214542 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 6,081E-03 0,03258071 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 6,081E-03 0,03250942 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 6,081E-03 0,03243844 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 6,081E-03 0,03236777 ! hormone transport GO:0009914 41 23 1,000 6,081E-03 0,0322974 ! negative regulation of cytokine production GO:0001818 41 23 1,000 6,081E-03 0,03222734 ! appendage development GO:0048736 151 73 2,000 6,22E-03 0,03289317 GO:0060173|limb development, ! regulation of caspase activity GO:0043281 136 74 2,000 6,459E-03 0,03408261 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 6,459E-03 0,03400916 ! respiratory system development GO:0060541 175 74 2,000 6,459E-03 0,03393602 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 6,612E-03 0,03466409 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 6,612E-03 0,03458987 ! barbed-end actin filament capping GO:0051016 58 24 1,000 6,612E-03 0,03451596 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 1,000 6,612E-03 0,03444236 ! membrane depolarization GO:0051899 45 24 1,000 6,612E-03 0,03436908 ! pallium development GO:0021543 56 24 1,000 6,612E-03 0,03429611 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 6,612E-03 0,03422345 ! negative regulation of catabolic process GO:0009895 52 24 1,000 6,612E-03 0,03415109 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 6,704E-03 0,03455075 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 7,163E-03 0,03684145 ! receptor metabolic process GO:0043112 53 25 1,000 7,163E-03 0,03676405 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 7,209E-03 0,03691941 ! regulation of catabolic process GO:0009894 173 77 2,000 7,209E-03 0,03684217 ! molting cycle process GO:0022404 52 26 1,000 7,734E-03 0,03944663 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 7,734E-03 0,03936445 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 7,734E-03 0,03928261 ! neural crest cell development GO:0014032 59 26 1,000 7,734E-03 0,03920111 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 1,000 7,734E-03 0,03911995 GO:0050768|negative regulation of neurogenesis, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 7,734E-03 0,03903912 ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 7,734E-03 0,03895863 ! blood coagulation GO:0007596 151 79 2,000 7,735E-03 0,03888418 GO:0050817|coagulation, ! negative regulation of actin filament polymerization GO:0030837 61 27 1,000 8,325E-03 0,0417632 ! cellular response to oxidative stress GO:0034599 43 27 1,000 8,325E-03 0,04167762 ! regulation of chromosome organization GO:0033044 49 27 1,000 8,325E-03 0,04159239 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 8,325E-03 0,0415075 ! regulation of peptidase activity GO:0052547 150 82 2,000 8,567E-03 0,04262761 ! cellular lipid catabolic process GO:0044242 150 83 2,000 8,856E-03 0,04397359 ! protein amino acid acylation GO:0043543 59 28 1,000 8,936E-03 0,04428071 ! dendrite development GO:0016358 67 28 1,000 8,936E-03 0,04419108 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 1,000 8,936E-03 0,0441018 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 8,936E-03 0,04401289 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 8,936E-03 0,04392433 ! negative regulation of protein polymerization GO:0032272 63 28 1,000 8,936E-03 0,04383613 ! hemostasis GO:0007599 165 85 2,000 9,45E-03 0,04626472 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 9,45E-03 0,04617219 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 9,566E-03 0,04664583 ! catechol metabolic process GO:0009712 55 29 1,000 9,566E-03 0,04655291 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! respiratory gaseous exchange GO:0007585 61 29 1,000 9,566E-03 0,04646036 ! somitogenesis GO:0001756 52 29 1,000 9,566E-03 0,04636817 ! regulation of protein transport GO:0051223 165 87 2,000 0,0100666 0,04869845 GO:0070201|regulation of establishment of protein localization, ! phenol metabolic process GO:0018958 56 30 1,000 0,01021517 0,04931949 ! negative regulation of protein complex assembly GO:0031333 68 30 1,000 0,01021517 0,04922222 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 1,000 0,01021517 0,04912532 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01021517 0,04902881 ! peptide transport GO:0015833 60 31 1,000 0,01088342 0,05213371 ! male gonad development GO:0008584 56 31 1,000 0,01088342 0,05203168 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01088342 0,05193006 ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 0,01088342 0,05182883 ! response to heat GO:0009408 54 31 1,000 0,01088342 0,051728 ! positive regulation of protein modification process GO:0031401 156 90 2,000 0,01103464 0,05234491 ! collagen metabolic process GO:0032963 49 32 1,000 0,01157046 0,05478029 ! metanephros development GO:0001656 81 32 1,000 0,01157046 0,05467433 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,01157046 0,05456879 ! BMP signaling pathway GO:0030509 71 32 1,000 0,01157046 0,05446364 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01157046 0,05435891 ! regulation of pH GO:0006885 56 33 1,000 0,01227609 0,0575633 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,01227609 0,05745303 ! establishment of vesicle localization GO:0051650 67 33 1,000 0,01227609 0,05734318 ! regulation of defense response GO:0031347 171 95 2,000 0,0127638 0,05950756 ! glial cell differentiation GO:0010001 67 34 1,000 0,0130001 0,06049379 ! regulation of protein localization GO:0032880 188 97 2,000 0,01349634 0,06268357 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01374229 0,06370477 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 0,01374229 0,06358412 ! telencephalon development GO:0021537 81 35 1,000 0,01374229 0,06346392 ! biogenic amine biosynthetic process GO:0042401 65 35 1,000 0,01374229 0,06334418 ! placenta development GO:0001890 53 35 1,000 0,01374229 0,06322489 ! vesicle localization GO:0051648 70 35 1,000 0,01374229 0,06310604 ! regulation of muscle development GO:0048634 82 36 1,000 0,01450246 0,06647187 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01450246 0,06634739 ! regulation of proteolysis GO:0030162 77 36 1,000 0,01450246 0,06622338 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01450246 0,06609983 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01463928 0,06659916 GO:0060538|skeletal muscle organ development, ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01528041 0,06938668 ! cell junction organization GO:0034330 96 37 1,000 0,01528041 0,06925794 ! tissue remodeling GO:0048771 78 37 1,000 0,01528041 0,06912969 ! hormone biosynthetic process GO:0042446 62 37 1,000 0,01528041 0,06900191 ! negative regulation of cell activation GO:0050866 69 37 1,000 0,01528041 0,0688746 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,01607593 0,07232689 ! cyclic nucleotide metabolic process GO:0009187 69 38 1,000 0,01607593 0,07219393 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,01607593 0,07206147 ! regulation of protein stability GO:0031647 77 38 1,000 0,01607593 0,07192949 ! mammary gland development GO:0030879 93 40 1,000 0,01771893 0,07913592 ! nucleus organization GO:0006997 73 40 1,000 0,01771893 0,07899151 ! regulation of hormone secretion GO:0046883 69 41 1,000 0,01856602 0,08261708 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 1,000 0,01856602 0,08246687 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01856602 0,0823172 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,01856602 0,08216808 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,0194299 0,08583589 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,0194299 0,08568096 ! regulation of protein secretion GO:0050708 77 42 1,000 0,0194299 0,08552658 ! cytokinesis GO:0000910 84 42 1,000 0,0194299 0,08537275 ! response to xenobiotic stimulus GO:0009410 63 42 1,000 0,0194299 0,08521948 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02031039 0,08892167 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,02031039 0,0887626 ! regulation of tube size GO:0035150 76 43 1,000 0,02031039 0,0886041 GO:0050880|regulation of blood vessel size, ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,02031039 0,08844616 ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,02031039 0,08828878 ! segmentation GO:0035282 78 43 1,000 0,02031039 0,08813196 ! neuron migration GO:0001764 85 43 1,000 0,02031039 0,0879757 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,02031039 0,08781999 ! phagocytosis GO:0006909 105 44 1,000 0,02120731 0,09153613 ! receptor-mediated endocytosis GO:0006898 98 45 1,000 0,02212045 0,0953091 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,02304964 0,09913779 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 1,000 0,02304964 0,09896355 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,02304964 0,09878993 ! cell growth GO:0016049 90 46 1,000 0,02304964 0,09861692 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,02304964 0,09844451 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,02399468 0,10230194 ! cellular component disassembly GO:0022411 89 48 1,000 0,0249554 0,10621263 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,0249554 0,10602792 ! male sex differentiation GO:0046661 93 48 1,000 0,0249554 0,10584384 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02520481 0,10671637 ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02520481 0,10653174 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02520481 0,10634775 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02520481 0,10616439 ! neuron fate determination GO:0048664 7 5 0,000 0,02520481 0,10598166 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02520481 0,10579956 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02520481 0,10561809 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02520481 0,10543724 ! polyol transport GO:0015791 12 5 0,000 0,02520481 0,105257 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02520481 0,10507738 ! response to superoxide GO:0000303 10 5 0,000 0,02520481 0,10489837 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02520481 0,10471998 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02520481 0,10454218 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02520481 0,10436499 ! female meiosis GO:0007143 10 5 0,000 0,02520481 0,1041884 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02520481 0,10401241 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02520481 0,10383701 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02520481 0,1036622 ! cobalt ion transport GO:0006824 11 5 0,000 0,02520481 0,10348798 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02520481 0,10331434 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02520481 0,10314128 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02520481 0,1029688 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02520481 0,1027969 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02520481 0,10262558 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02520481 0,10245482 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02520481 0,10228463 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02520481 0,102115 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02520481 0,10194594 ! transposition GO:0032196 9 5 0,000 0,02520481 0,10177743 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02520481 0,10160948 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,02520481 0,10144208 ! negative chemotaxis GO:0050919 16 5 0,000 0,02520481 0,10127524 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02520481 0,10110894 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02520481 0,10094319 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02520481 0,10077798 ! behavioral response to pain GO:0048266 10 5 0,000 0,02520481 0,10061331 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02520481 0,10044918 ! Notch receptor processing GO:0007220 11 5 0,000 0,02520481 0,10028558 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02520481 0,10012251 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02520481 0,09995998 ! micturition GO:0060073 9 5 0,000 0,02520481 0,09979797 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02520481 0,09963648 ! copulation GO:0007620 9 5 0,000 0,02520481 0,09947552 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02520481 0,09931507 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02520481 0,09915515 ! bioluminescence GO:0008218 9 5 0,000 0,02520481 0,09899573 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02520481 0,09883683 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02520481 0,09867844 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02520481 0,09852055 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02520481 0,09836317 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02520481 0,09820629 ! grooming behavior GO:0007625 6 5 0,000 0,02520481 0,09804991 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02520481 0,09789403 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02520481 0,09773864 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02520481 0,09758375 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02520481 0,09742934 ! response to protozoan GO:0001562 13 5 0,000 0,02520481 0,09727543 ! lymph vessel development GO:0001945 10 5 0,000 0,02520481 0,097122 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02520481 0,09696905 ! endochondral ossification GO:0001958 17 5 0,000 0,02520481 0,09681658 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02520481 0,09666459 ! single strand break repair GO:0000012 8 5 0,000 0,02520481 0,09651308 ! parathyroid gland development GO:0060017 14 5 0,000 0,02520481 0,09636204 ! anagen GO:0042640 7 5 0,000 0,02520481 0,09621148 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02520481 0,09606138 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02520481 0,09591175 ! cytokine secretion GO:0050663 15 5 0,000 0,02520481 0,09576259 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02520481 0,09561389 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02520481 0,09546565 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02520481 0,09531787 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02520481 0,09517055 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02520481 0,09502368 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02520481 0,09487727 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02520481 0,0947313 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02520481 0,09458578 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02520481 0,09444071 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02520481 0,09429609 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02520481 0,0941519 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02520481 0,09400816 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02520481 0,09386486 ! valine metabolic process GO:0006573 12 5 0,000 0,02520481 0,09372199 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02520481 0,09357955 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02520481 0,09343755 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02520481 0,09329598 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02520481 0,09315483 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02520481 0,09301412 ! polyol catabolic process GO:0046174 9 5 0,000 0,02520481 0,09287382 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02520481 0,09273395 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02520481 0,0925945 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02520481 0,09245547 ! muscle cell migration GO:0014812 8 5 0,000 0,02520481 0,09231686 ! mitochondrial fission GO:0000266 8 5 0,000 0,02520481 0,09217866 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02520481 0,09204087 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02520481 0,0919035 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02520481 0,09176654 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02520481 0,09162998 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02520481 0,09149383 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02520481 0,09135808 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02520481 0,09122273 ! monocyte activation GO:0042117 10 5 0,000 0,02520481 0,09108779 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02520481 0,09095324 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02520481 0,09081909 ! response to food GO:0032094 6 5 0,000 0,02520481 0,09068534 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02520481 0,09055198 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02520481 0,09041901 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02520481 0,09028643 ! forebrain neuron development GO:0021884 13 5 0,000 0,02520481 0,09015424 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02520481 0,09002243 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02520481 0,08989102 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02520481 0,08975998 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02520481 0,08962932 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02520481 0,08949905 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02520481 0,08936915 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02520481 0,08923963 ! lipid glycosylation GO:0030259 7 5 0,000 0,02520481 0,08911049 ! nucleobase transport GO:0015851 6 5 0,000 0,02520481 0,08898171 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02520481 0,08885331 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02520481 0,08872528 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02520481 0,08859762 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02520481 0,08847032 ! basic amino acid transport GO:0015802 12 5 0,000 0,02520481 0,08834339 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02520481 0,08821683 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02520481 0,08809062 ! actin nucleation GO:0045010 11 5 0,000 0,02520481 0,08796478 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02520481 0,08783929 ! depurination GO:0045007 5 5 0,000 0,02520481 0,08771417 ! depyrimidination GO:0045008 10 5 0,000 0,02520481 0,0875894 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02520481 0,08746498 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02520481 0,08734092 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02520481 0,0872172 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02520481 0,08709384 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02520481 0,08697083 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,02520481 0,08684816 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02520481 0,08672584 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02520481 0,08660386 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02520481 0,08648223 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02520481 0,08636093 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02520481 0,08623998 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02520481 0,08611936 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02520481 0,08599909 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02520481 0,08587914 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02520481 0,08575953 ! response to arsenic GO:0046685 11 5 0,000 0,02520481 0,08564026 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02520481 0,08552131 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02520481 0,0854027 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02520481 0,08528441 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02520481 0,08516645 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02520481 0,08504882 ! response to mercury ion GO:0046689 8 5 0,000 0,02520481 0,08493151 ! response to cadmium ion GO:0046686 7 5 0,000 0,02520481 0,08481453 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02520481 0,08469786 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02520481 0,08458152 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02520481 0,08446549 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02520481 0,08434979 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02520481 0,0842344 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02520481 0,08411932 ! decidualization GO:0046697 11 5 0,000 0,02520481 0,08400456 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02520481 0,08389012 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02520481 0,08377598 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02520481 0,08366215 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02520481 0,08354864 ! embryonic cleavage GO:0040016 6 5 0,000 0,02520481 0,08343543 ! peroxisome fission GO:0016559 5 5 0,000 0,02520481 0,08332252 ! histone demethylation GO:0016577 13 5 0,000 0,02520481 0,08320993 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02520481 0,08309763 ! mitotic recombination GO:0006312 9 5 0,000 0,02520481 0,08298564 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02520481 0,08287395 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02520481 0,08276256 ! metaphase plate congression GO:0051310 7 5 0,000 0,02520481 0,08265147 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02520481 0,08254068 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02520481 0,08243018 ! enteric nervous system development GO:0048484 8 5 0,000 0,02520481 0,08231998 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02520481 0,08221007 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02520481 0,08210046 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02520481 0,08199114 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02520481 0,08188211 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02520481 0,08177337 ! B cell homeostasis GO:0001782 13 5 0,000 0,02520481 0,08166491 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02520481 0,08155675 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02520481 0,08144887 ! metaphase GO:0051323 11 5 0,000 0,02520481 0,08134128 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02520481 0,08123396 GO:0030186|melatonin metabolic process, ! cellular response to nutrient GO:0031670 8 5 0,000 0,02520481 0,08112694 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02520481 0,08102019 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02520481 0,08091373 ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02520481 0,08080754 ! response to redox state GO:0051775 6 5 0,000 0,02520481 0,08070163 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02520481 0,080596 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02520481 0,08049065 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02520481 0,08038557 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02520481 0,08028076 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02520481 0,08017623 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02520481 0,08007197 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02520481 0,07996798 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02520481 0,07986426 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02520481 0,07976081 ! striatum development GO:0021756 14 5 0,000 0,02520481 0,07965763 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02520481 0,07955471 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02520481 0,07945206 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02520481 0,07934967 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02520481 0,07924755 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02520481 0,07914569 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02520481 0,07904409 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02520481 0,07894275 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02520481 0,07884167 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02520481 0,07874085 ! neuroprotection GO:0043526 8 5 0,000 0,02520481 0,07864029 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02520481 0,07853998 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02520481 0,07843993 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02520481 0,07834013 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02520481 0,07824059 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02520481 0,0781413 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02520481 0,07804226 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02520481 0,07794348 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02520481 0,07784494 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02520481 0,07774665 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02520481 0,07764861 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02520481 0,07755081 ! spindle assembly GO:0051225 6 5 0,000 0,02520481 0,07745326 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02520481 0,07735596 ! protein palmitoylation GO:0018345 12 5 0,000 0,02520481 0,0772589 ! drug metabolic process GO:0017144 7 5 0,000 0,02520481 0,07716209 ! organ regeneration GO:0031100 7 5 0,000 0,02520481 0,07706551 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02520481 0,07696918 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02520481 0,07687309 ! response to calcium ion GO:0051592 94 49 1,000 0,02593162 0,0789912 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,02593162 0,07889283 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 0,02593162 0,07879471 ! protein homooligomerization GO:0051260 84 49 1,000 0,02593162 0,07869683 ! endocrine system development GO:0035270 109 50 1,000 0,02692315 0,08160452 ! activation of caspase activity GO:0006919 95 50 1,000 0,02692315 0,0815034 ! regulation of ossification GO:0030278 123 50 1,000 0,02692315 0,08140253 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,02692315 0,08130191 ! response to temperature stimulus GO:0009266 84 51 1,000 0,0279298 0,08423767 ! positive regulation of binding GO:0051099 88 52 1,000 0,02895142 0,08721124 ! excretion GO:0007588 87 52 1,000 0,02895142 0,08710384 ! histone modification GO:0016570 104 52 1,000 0,02895142 0,0869967 ! vesicle organization GO:0016050 127 53 1,000 0,02998781 0,09000027 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,02998781 0,08988984 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! synapse organization GO:0050808 102 53 1,000 0,02998781 0,08977969 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03016944 0,09021289 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03016944 0,09010261 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03016944 0,08999259 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03016944 0,08988284 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03016944 0,08977336 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03016944 0,08966415 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03016944 0,0895552 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03016944 0,08944652 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03016944 0,0893381 ! response to oxygen radical GO:0000305 11 6 0,000 0,03016944 0,08922994 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03016944 0,08912205 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03016944 0,08901441 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03016944 0,08890704 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03016944 0,08879992 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03016944 0,08869306 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03016944 0,08858646 ! forebrain regionalization GO:0021871 9 6 0,000 0,03016944 0,08848011 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03016944 0,08837402 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03016944 0,08826818 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03016944 0,0881626 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03016944 0,08805727 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03016944 0,08795219 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03016944 0,08784736 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03016944 0,08774278 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03016944 0,08763845 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03016944 0,08753436 ! malate metabolic process GO:0006108 13 6 0,000 0,03016944 0,08743053 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03016944 0,08732693 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03016944 0,08722359 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03016944 0,08712049 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03016944 0,08701763 ! protein refolding GO:0042026 15 6 0,000 0,03016944 0,08691501 ! opsonization GO:0008228 8 6 0,000 0,03016944 0,08681264 ! mating behavior GO:0007617 7 6 0,000 0,03016944 0,08671051 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03016944 0,08660862 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,03016944 0,08650696 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03016944 0,08640555 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03016944 0,08630437 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03016944 0,08620343 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03016944 0,08610273 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03016944 0,08600226 ! toxin metabolic process GO:0009404 11 6 0,000 0,03016944 0,08590202 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03016944 0,08580202 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03016944 0,08570225 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03016944 0,08560271 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03016944 0,0855034 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03016944 0,08540433 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03016944 0,08530548 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03016944 0,08520686 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03016944 0,08510847 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03016944 0,0850103 ! thymic T cell selection GO:0045061 16 6 0,000 0,03016944 0,08491236 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03016944 0,08481465 ! protein lipoylation GO:0009249 10 6 0,000 0,03016944 0,08471716 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03016944 0,0846199 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03016944 0,08452286 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03016944 0,08442604 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03016944 0,08432944 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03016944 0,08423307 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03016944 0,08413691 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03016944 0,08404097 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03016944 0,08394525 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03016944 0,08384975 ! hyperosmotic response GO:0006972 10 6 0,000 0,03016944 0,08375447 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03016944 0,0836594 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03016944 0,08356455 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03016944 0,08346991 ! urea metabolic process GO:0019627 7 6 0,000 0,03016944 0,08337549 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03016944 0,08328128 ! neutrophil activation GO:0042119 7 6 0,000 0,03016944 0,08318728 ! regulation of appetite GO:0032098 10 6 0,000 0,03016944 0,0830935 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03016944 0,08299992 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03016944 0,08290656 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03016944 0,08281341 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03016944 0,08272046 ! neuron apoptosis GO:0051402 15 6 0,000 0,03016944 0,08262773 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03016944 0,0825352 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03016944 0,08244288 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03016944 0,08235076 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03016944 0,08225885 ! carnitine transport GO:0015879 10 6 0,000 0,03016944 0,08216715 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03016944 0,08207565 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03016944 0,08198435 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03016944 0,08189326 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03016944 0,08180237 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03016944 0,08171168 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03016944 0,08162119 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03016944 0,0815309 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03016944 0,08144081 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03016944 0,08135092 ! establishment of spindle localization GO:0051293 16 6 0,000 0,03016944 0,08126123 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03016944 0,08117173 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03016944 0,08108243 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,03016944 0,08099333 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03016944 0,08090443 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03016944 0,08081572 ! interaction with symbiont GO:0051702 14 6 0,000 0,03016944 0,0807272 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03016944 0,08063888 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03016944 0,08055075 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03016944 0,08046281 ! response to copper ion GO:0046688 10 6 0,000 0,03016944 0,08037506 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03016944 0,08028751 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03016944 0,08020014 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03016944 0,08011297 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03016944 0,08002599 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03016944 0,07993919 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03016944 0,07985258 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03016944 0,07976616 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03016944 0,07967993 ! hair follicle maturation GO:0048820 8 6 0,000 0,03016944 0,07959388 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03016944 0,07950802 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03016944 0,07942234 ! response to pheromone GO:0019236 6 6 0,000 0,03016944 0,07933685 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03016944 0,07925154 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03016944 0,07916642 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,03016944 0,07908147 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03016944 0,07899671 ! subpallium development GO:0021544 15 6 0,000 0,03016944 0,07891213 ! neural tube patterning GO:0021532 8 6 0,000 0,03016944 0,07882774 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03016944 0,07874352 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03016944 0,07865948 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03016944 0,07857562 ! G2 phase GO:0051319 16 6 0,000 0,03016944 0,07849194 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03016944 0,07840844 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03016944 0,07832511 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03016944 0,07824197 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03016944 0,078159 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03016944 0,0780762 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03016944 0,07799358 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03016944 0,07791113 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03016944 0,07782886 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03016944 0,07774676 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03016944 0,07766484 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03016944 0,07758309 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03016944 0,07750151 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 16 6 0,000 0,03016944 0,0774201 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03016944 0,07733886 ! protein destabilization GO:0031648 9 6 0,000 0,03016944 0,07725779 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03016944 0,07717689 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03016944 0,07709616 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03016944 0,0770156 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03016944 0,07693521 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03016944 0,07685499 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03016944 0,07677493 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03016944 0,07669504 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03016944 0,07661531 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03016944 0,07653576 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03016944 0,07645636 ! neural plate development GO:0001840 9 6 0,000 0,03016944 0,07637713 ! catecholamine transport GO:0051937 9 6 0,000 0,03016944 0,07629807 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03016944 0,07621917 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03016944 0,07614043 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03016944 0,07606185 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03016944 0,07598344 ! maternal placenta development GO:0001893 12 6 0,000 0,03016944 0,07590518 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03016944 0,07582709 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03016944 0,07574916 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,03016944 0,07567139 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03016944 0,07559378 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03016944 0,07551632 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03016944 0,07543903 GO:0055081|anion homeostasis, ! embryonic skeletal system development GO:0048706 101 54 1,000 0,03103881 0,07753354 ! covalent chromatin modification GO:0016569 115 54 1,000 0,03103881 0,07745435 ! regulation of cell shape GO:0008360 142 54 1,000 0,03103881 0,07737531 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 0,03210423 0,07994968 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03210423 0,07986827 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,03210423 0,07978702 ! response to UV GO:0009411 120 55 1,000 0,03210423 0,07970593 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,03318391 0,08230284 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,03318391 0,08221937 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,03427768 0,08484334 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,03427768 0,08475746 ! heart morphogenesis GO:0003007 105 57 1,000 0,03427768 0,08467176 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,03427768 0,08458624 ! tRNA transcription GO:0009304 17 7 0,000 0,03510892 0,08655004 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03510892 0,08646279 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03510892 0,08637572 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03510892 0,08628882 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03510892 0,0862021 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03510892 0,08611555 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03510892 0,08602918 ! sleep GO:0030431 16 7 0,000 0,03510892 0,08594297 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03510892 0,08585695 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03510892 0,08577109 ! prostate gland development GO:0030850 14 7 0,000 0,03510892 0,0856854 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03510892 0,08559989 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03510892 0,08551454 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03510892 0,08542937 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03510892 0,08534437 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03510892 0,08525953 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03510892 0,08517486 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03510892 0,08509037 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03510892 0,08500603 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03510892 0,08492187 ! glycolipid transport GO:0046836 11 7 0,000 0,03510892 0,08483787 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03510892 0,08475404 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,03510892 0,08467037 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03510892 0,08458687 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03510892 0,08450354 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03510892 0,08442036 ! pericardium development GO:0060039 16 7 0,000 0,03510892 0,08433735 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03510892 0,08425451 GO:0031958|corticosteroid receptor signaling pathway, ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03510892 0,08417182 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03510892 0,0840893 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03510892 0,08400694 ! lipoprotein transport GO:0042953 14 7 0,000 0,03510892 0,08392474 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03510892 0,08384271 ! rhythmic behavior GO:0007622 17 7 0,000 0,03510892 0,08376083 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03510892 0,08367911 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03510892 0,08359755 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03510892 0,08351615 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03510892 0,08343491 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03510892 0,08335383 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03510892 0,0832729 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03510892 0,08319213 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03510892 0,08311152 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03510892 0,08303106 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03510892 0,08295076 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03510892 0,08287062 GO:0045911|positive regulation of DNA recombination, ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03510892 0,08279063 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03510892 0,08271079 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03510892 0,08263111 ! spinal cord patterning GO:0021511 14 7 0,000 0,03510892 0,08255158 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03510892 0,0824722 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03510892 0,08239298 ! adrenal gland development GO:0030325 17 7 0,000 0,03510892 0,0823139 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03510892 0,08223498 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03510892 0,08215622 ! ovulation GO:0030728 10 7 0,000 0,03510892 0,0820776 ! adenohypophysis development GO:0021984 11 7 0,000 0,03510892 0,08199913 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03510892 0,08192081 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03510892 0,08184264 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! microtubule nucleation GO:0007020 21 7 0,000 0,03510892 0,08176462 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03510892 0,08168675 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03510892 0,08160903 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03510892 0,08153145 ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03510892 0,08145403 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03510892 0,08137674 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03510892 0,08129961 ! galactose metabolic process GO:0006012 13 7 0,000 0,03510892 0,08122262 ! vesicle fusion GO:0006906 20 7 0,000 0,03510892 0,08114578 ! response to dietary excess GO:0002021 8 7 0,000 0,03510892 0,08106908 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03510892 0,08099253 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03510892 0,08091612 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03510892 0,08083986 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 0,000 0,03510892 0,08076374 ! nucleoside transport GO:0015858 11 7 0,000 0,03510892 0,08068776 ! nucleoside salvage GO:0043174 11 7 0,000 0,03510892 0,08061193 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03510892 0,08053623 ! male sex determination GO:0030238 15 7 0,000 0,03510892 0,08046068 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03510892 0,08038528 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03510892 0,08031001 ! parturition GO:0007567 16 7 0,000 0,03510892 0,08023488 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03510892 0,0801599 ! rRNA modification GO:0000154 14 7 0,000 0,03510892 0,08008505 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03510892 0,08001034 ! spindle checkpoint GO:0031577 16 7 0,000 0,03510892 0,07993578 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03510892 0,07986135 ! monocyte differentiation GO:0030224 16 7 0,000 0,03510892 0,07978706 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03510892 0,07971291 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03510892 0,07963889 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03510892 0,07956502 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03510892 0,07949128 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03510892 0,07941767 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03510892 0,07934421 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03510892 0,07927088 ! eating behavior GO:0042755 8 7 0,000 0,03510892 0,07919768 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03510892 0,07912462 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03510892 0,07905169 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03510892 0,0789789 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03510892 0,07890625 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03510892 0,07883372 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03510892 0,07876133 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03510892 0,07868907 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03510892 0,07861695 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03510892 0,07854495 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03510892 0,07847309 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03510892 0,07840136 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03510892 0,07832976 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03510892 0,07825829 ! histone ubiquitination GO:0016574 9 7 0,000 0,03510892 0,07818695 ! regulation of meiosis GO:0040020 12 7 0,000 0,03510892 0,07811575 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03510892 0,07804467 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03510892 0,07797372 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03510892 0,0779029 GO:0002714|positive regulation of B cell mediated immunity, ! membrane to membrane docking GO:0022614 14 7 0,000 0,03510892 0,0778322 ! transcription termination GO:0006353 14 7 0,000 0,03510892 0,07776164 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03510892 0,0776912 ! anaphase GO:0051322 18 7 0,000 0,03510892 0,07762089 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03510892 0,07755071 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03510892 0,07748066 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03510892 0,07741073 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03510892 0,07734093 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03510892 0,07727125 ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03510892 0,0772017 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03510892 0,07713227 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03510892 0,07706297 ! antibiotic transport GO:0042891 9 7 0,000 0,03510892 0,0769938 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03510892 0,07692474 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03510892 0,07685581 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03510892 0,07678701 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03510892 0,07671833 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03510892 0,07664977 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03510892 0,07658133 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03510892 0,07651301 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03510892 0,07644482 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03510892 0,07637675 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03510892 0,0763088 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03510892 0,07624097 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03510892 0,07617326 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03510892 0,07610567 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03510892 0,0760382 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03510892 0,07597085 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03510892 0,07590362 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03510892 0,07583651 ! muscle adaptation GO:0043500 13 7 0,000 0,03510892 0,07576951 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03510892 0,07570264 ! retina homeostasis GO:0001895 12 7 0,000 0,03510892 0,07563588 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03510892 0,07556924 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03510892 0,07550272 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03510892 0,07543631 ! gastrulation GO:0007369 122 58 1,000 0,03538536 0,07596348 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 1,000 0,03538536 0,07589679 ! establishment of organelle localization GO:0051656 122 59 1,000 0,03650679 0,07823342 ! lipid modification GO:0030258 112 60 1,000 0,03764181 0,08059503 ! DNA catabolic process GO:0006308 94 60 1,000 0,03764181 0,08052446 ! kidney development GO:0001822 133 60 1,000 0,03764181 0,08045401 ! positive regulation of secretion GO:0051047 110 61 1,000 0,03879023 0,08283613 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04002338 0,08539487 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04002338 0,08532035 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04002338 0,08524597 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04002338 0,08517171 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04002338 0,08509758 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04002338 0,08502358 ! male meiosis GO:0007140 9 8 0,000 0,04002338 0,08494972 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04002338 0,08487597 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04002338 0,08480236 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04002338 0,08472888 ! meiotic prophase I GO:0007128 14 8 0,000 0,04002338 0,08465552 ! response to zinc ion GO:0010043 12 8 0,000 0,04002338 0,08458229 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04002338 0,08450918 ! oligopeptide transport GO:0006857 16 8 0,000 0,04002338 0,0844362 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04002338 0,08436335 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04002338 0,08429062 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04002338 0,08421802 ! signal peptide processing GO:0006465 12 8 0,000 0,04002338 0,08414554 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04002338 0,08407319 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04002338 0,08400096 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04002338 0,08392886 ! succinate metabolic process GO:0006105 17 8 0,000 0,04002338 0,08385688 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04002338 0,08378502 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04002338 0,08371329 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04002338 0,08364168 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04002338 0,08357019 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04002338 0,08349882 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04002338 0,08342758 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04002338 0,08335646 ! reflex GO:0060004 17 8 0,000 0,04002338 0,08328545 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04002338 0,08321457 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04002338 0,08314381 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04002338 0,08307317 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04002338 0,08300265 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04002338 0,08293225 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04002338 0,08286197 ! histidine catabolic process GO:0006548 10 8 0,000 0,04002338 0,08279181 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04002338 0,08272176 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04002338 0,08265184 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04002338 0,08258203 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,04002338 0,08251234 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04002338 0,08244277 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04002338 0,08237331 ! melanin metabolic process GO:0006582 17 8 0,000 0,04002338 0,08230398 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04002338 0,08223475 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04002338 0,08216565 ! macrophage activation GO:0042116 13 8 0,000 0,04002338 0,08209666 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,04002338 0,08202779 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04002338 0,08195903 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04002338 0,08189039 ! purine salvage GO:0043101 12 8 0,000 0,04002338 0,08182186 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04002338 0,08175345 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04002338 0,08168515 ! osteoblast development GO:0002076 17 8 0,000 0,04002338 0,08161696 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04002338 0,08154889 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04002338 0,08148094 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04002338 0,08141309 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04002338 0,08134536 ! response to UV-B GO:0010224 17 8 0,000 0,04002338 0,08127774 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04002338 0,08121023 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04002338 0,08114284 ! intermediate filament organization GO:0045109 12 8 0,000 0,04002338 0,08107556 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04002338 0,08100839 ! cellular extravasation GO:0045123 13 8 0,000 0,04002338 0,08094133 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04002338 0,08087438 ! response to antibiotic GO:0046677 11 8 0,000 0,04002338 0,08080754 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04002338 0,08074081 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04002338 0,08067419 ! DNA topological change GO:0006265 12 8 0,000 0,04002338 0,08060769 ! response to tropane GO:0014073 15 8 0,000 0,04002338 0,08054129 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04002338 0,080475 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04002338 0,08040882 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04002338 0,08034275 ! mast cell activation GO:0045576 14 8 0,000 0,04002338 0,08027678 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04002338 0,08021093 ! gas homeostasis GO:0033483 14 8 0,000 0,04002338 0,08014518 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04002338 0,08007954 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04002338 0,08001401 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04002338 0,07994859 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04002338 0,07988327 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04002338 0,07981806 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04002338 0,07975295 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04002338 0,07968796 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04002338 0,07962306 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04002338 0,07955828 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04002338 0,0794936 ! response to tumor cell GO:0002347 16 8 0,000 0,04002338 0,07942902 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04002338 0,07936455 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04002338 0,07930018 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04002338 0,07923592 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04002338 0,07917176 ! hormone catabolic process GO:0042447 17 8 0,000 0,04002338 0,0791077 ! lymph node development GO:0048535 11 8 0,000 0,04002338 0,07904375 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04002338 0,07897991 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04002338 0,07891616 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04002338 0,07885252 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04002338 0,07878898 ! adult feeding behavior GO:0008343 10 8 0,000 0,04002338 0,07872554 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04002338 0,07866221 ! ATP catabolic process GO:0006200 11 8 0,000 0,04002338 0,07859897 ! blastocyst growth GO:0001832 19 8 0,000 0,04002338 0,07853584 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04002338 0,07847281 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04002338 0,07840988 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04002338 0,07834705 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04002338 0,07828433 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04002338 0,0782217 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04002338 0,07815917 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04002338 0,07809674 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04002338 0,07803442 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04002338 0,07797219 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04002338 0,07791006 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04002338 0,07784803 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04002338 0,0777861 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04002338 0,07772426 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04002338 0,07766253 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04002338 0,07760089 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04002338 0,07753935 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,04112667 0,07961368 ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 0,04351482 0,08416999 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,04472788 0,08644795 ! gonad development GO:0008406 115 66 1,000 0,04472788 0,08637961 ! axon extension GO:0048675 16 9 0,000 0,04491295 0,08666852 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04491295 0,08660011 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04491295 0,08653182 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04491295 0,08646363 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04491295 0,08639555 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,04491295 0,08632757 ! reproductive behavior GO:0019098 22 9 0,000 0,04491295 0,0862597 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04491295 0,08619194 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04491295 0,08612429 ! UTP metabolic process GO:0046051 10 9 0,000 0,04491295 0,08605674 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04491295 0,0859893 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04491295 0,08592196 ! artery development GO:0060840 25 9 0,000 0,04491295 0,08585473 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04491295 0,0857876 ! equilibrioception GO:0050957 20 9 0,000 0,04491295 0,08572058 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,04491295 0,08565366 ! chemosensory behavior GO:0007635 21 9 0,000 0,04491295 0,08558685 ! microtubule bundle formation GO:0001578 22 9 0,000 0,04491295 0,08552014 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04491295 0,08545354 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04491295 0,08538704 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04491295 0,08532064 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04491295 0,08525435 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04491295 0,08518815 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04491295 0,08512207 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04491295 0,08505608 ! protein targeting to ER GO:0045047 25 9 0,000 0,04491295 0,0849902 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04491295 0,08492441 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,04491295 0,08485873 ! T cell selection GO:0045058 27 9 0,000 0,04491295 0,08479316 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04491295 0,08472768 ! glycine catabolic process GO:0006546 15 9 0,000 0,04491295 0,0846623 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04491295 0,08459703 ! endosome organization GO:0007032 20 9 0,000 0,04491295 0,08453185 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04491295 0,08446678 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04491295 0,0844018 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04491295 0,08433693 ! mannose metabolic process GO:0006013 13 9 0,000 0,04491295 0,08427215 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04491295 0,08420748 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04491295 0,0841429 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,04491295 0,08407842 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04491295 0,08401404 ! receptor clustering GO:0043113 20 9 0,000 0,04491295 0,08394976 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04491295 0,08388558 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04491295 0,0838215 ! retinol metabolic process GO:0042572 20 9 0,000 0,04491295 0,08375751 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04491295 0,08369363 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04491295 0,08362983 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,04491295 0,08356614 ! macrophage differentiation GO:0030225 15 9 0,000 0,04491295 0,08350254 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04491295 0,08343904 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,04491295 0,08337564 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04491295 0,08331233 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04491295 0,08324912 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04491295 0,08318601 ! response to amine stimulus GO:0014075 13 9 0,000 0,04491295 0,08312299 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04491295 0,08306006 ! erythrocyte development GO:0048821 17 9 0,000 0,04491295 0,08299723 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04491295 0,0829345 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,04491295 0,08287186 ! postreplication repair GO:0006301 25 9 0,000 0,04491295 0,08280932 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04491295 0,08274686 ! icosanoid secretion GO:0032309 15 9 0,000 0,04491295 0,08268451 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04491295 0,08262225 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04491295 0,08256008 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04491295 0,082498 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04491295 0,08243602 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04491295 0,08237413 ! sterol catabolic process GO:0016127 14 9 0,000 0,04491295 0,08231234 GO:0006707|cholesterol catabolic process, ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04491295 0,08225063 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04491295 0,08218902 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,04491295 0,0821275 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,04491295 0,08206608 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,04491295 0,08200474 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04491295 0,0819435 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04491295 0,08188235 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04491295 0,08182128 ! purine base metabolic process GO:0006144 25 9 0,000 0,04491295 0,08176032 ! pigment granule transport GO:0051904 17 9 0,000 0,04491295 0,08169944 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04491295 0,08163865 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04491295 0,08157795 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04491295 0,08151734 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,04491295 0,08145682 ! mitochondrion localization GO:0051646 18 9 0,000 0,04491295 0,0813964 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,04595339 0,08322025 ! adaptive immune response GO:0002250 126 68 1,000 0,04719119 0,08539857 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,04719119 0,08533536 ! negative regulation of cell size GO:0045792 144 69 1,000 0,04844112 0,08753081 ! cellular hormone metabolic process GO:0034754 120 69 1,000 0,04844112 0,08746612 ! urogenital system development GO:0001655 149 69 1,000 0,04844112 0,08740152 ! germ cell development GO:0007281 133 70 1,000 0,04970304 0,08961219 ! regulation of developmental growth GO:0048638 16 10 0,000 0,04977775 0,08968072 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,04977775 0,08961463 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04977775 0,08954864 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04977775 0,08948275 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04977775 0,08941695 ! associative learning GO:0008306 21 10 0,000 0,04977775 0,08935125 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,04977775 0,08928565 ! phosphate transport GO:0006817 24 10 0,000 0,04977775 0,08922014 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04977775 0,08915473 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,04977775 0,08908942 ! CTP metabolic process GO:0046036 11 10 0,000 0,04977775 0,0890242 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 11 10 0,000 0,04977775 0,08895907 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04977775 0,08889405 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04977775 0,08882911 ! social behavior GO:0035176 29 10 0,000 0,04977775 0,08876427 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04977775 0,08869953 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04977775 0,08863488 ! androgen metabolic process GO:0008209 17 10 0,000 0,04977775 0,08857032 ! phospholipid efflux GO:0033700 19 10 0,000 0,04977775 0,08850586 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,04977775 0,08844149 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04977775 0,08837722 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04977775 0,08831304 ! pathogenesis GO:0009405 17 10 0,000 0,04977775 0,08824895 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04977775 0,08818496 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04977775 0,08812105 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04977775 0,08805724 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04977775 0,08799353 ! endoderm development GO:0007492 18 10 0,000 0,04977775 0,0879299 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,04977775 0,08786637 ! arginine catabolic process GO:0006527 17 10 0,000 0,04977775 0,08780293 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,04977775 0,08773958 ! proline metabolic process GO:0006560 13 10 0,000 0,04977775 0,08767632 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,04977775 0,08761315 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,04977775 0,08755008 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,04977775 0,08748709 ! V(D)J recombination GO:0033151 34 10 0,000 0,04977775 0,08742419 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04977775 0,08736139 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04977775 0,08729868 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04977775 0,08723605 ! B cell proliferation GO:0042100 19 10 0,000 0,04977775 0,08717352 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04977775 0,08711107 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04977775 0,08704872 ! multicellular organism growth GO:0035264 19 10 0,000 0,04977775 0,08698645 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04977775 0,08692427 ! epithelial cell development GO:0002064 21 10 0,000 0,04977775 0,08686218 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04977775 0,08680018 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04977775 0,08673827 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04977775 0,08667645 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04977775 0,08661471 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,04977775 0,08655306 ! copper ion homeostasis GO:0055070 13 10 0,000 0,04977775 0,0864915 ! protein heterooligomerization GO:0051291 17 10 0,000 0,04977775 0,08643003 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,04977775 0,08636865 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,04977775 0,08630735 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,04977775 0,08624614 ! segment specification GO:0007379 15 10 0,000 0,04977775 0,08618501 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,04977775 0,08612398 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04977775 0,08606303 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04977775 0,08600216 ! response to dsRNA GO:0043331 23 10 0,000 0,04977775 0,08594138 ! DNA ligation GO:0006266 18 10 0,000 0,04977775 0,08588069 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,04977775 0,08582008 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04977775 0,08575956 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04977775 0,08569912 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,04977775 0,08563877 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,04977775 0,0855785 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,04977775 0,08551832 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,04977775 0,08545823 ! induction of an organ GO:0001759 17 10 0,000 0,04977775 0,08539821 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04977775 0,08533828 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04977775 0,08527844 ! protein sumoylation GO:0016925 17 10 0,000 0,04977775 0,08521868 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,04977775 0,085159 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04977775 0,08509941 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04977775 0,0850399 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04977775 0,08498047 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04977775 0,08492113 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04977775 0,08486187 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,04977775 0,08480269 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04977775 0,08474359 GO:0050879|multicellular organismal movement, ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04977775 0,08468458 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,04977775 0,08462565 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,04977775 0,0845668 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04977775 0,08450803 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04977775 0,08444934 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,04977775 0,08439074 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04977775 0,08433222 ! detection of calcium ion GO:0005513 24 10 0,000 0,04977775 0,08427377 ! blastocyst formation GO:0001825 18 10 0,000 0,04977775 0,08421541 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04977775 0,08415713 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04977775 0,08409893 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04977775 0,08404081 ! response to nicotine GO:0035094 20 10 0,000 0,04977775 0,08398277 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,04977775 0,08392481 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05461791 0,09202177 ! respiratory burst GO:0045730 17 11 0,000 0,05461791 0,09195835 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05461791 0,09189502 ! neuron fate specification GO:0048665 18 11 0,000 0,05461791 0,09183177 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05461791 0,09176861 ! thyroid gland development GO:0030878 26 11 0,000 0,05461791 0,09170554 ! synapsis GO:0007129 14 11 0,000 0,05461791 0,09164256 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05461791 0,09157966 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05461791 0,09151685 ! response to pain GO:0048265 27 11 0,000 0,05461791 0,09145412 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05461791 0,09139148 ! bone resorption GO:0045453 16 11 0,000 0,05461791 0,09132893 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05461791 0,09126646 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05461791 0,09120408 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05461791 0,09114178 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05461791 0,09107957 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05461791 0,09101744 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05461791 0,0909554 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05461791 0,09089344 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05461791 0,09083156 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05461791 0,09076977 ! UV protection GO:0009650 20 11 0,000 0,05461791 0,09070807 ! adult heart development GO:0007512 16 11 0,000 0,05461791 0,09064644 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05461791 0,0905849 ! macroautophagy GO:0016236 19 11 0,000 0,05461791 0,09052345 ! temperature homeostasis GO:0001659 18 11 0,000 0,05461791 0,09046208 ! behavioral fear response GO:0001662 27 11 0,000 0,05461791 0,09040079 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 0,000 0,05461791 0,09033958 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05461791 0,09027846 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,05461791 0,09021742 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,05461791 0,09015646 ! regulation of organ growth GO:0046620 14 11 0,000 0,05461791 0,09009559 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,05461791 0,09003479 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05461791 0,08997408 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05461791 0,08991345 ! embryonic axis specification GO:0000578 19 11 0,000 0,05461791 0,08985291 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05461791 0,08979244 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05461791 0,08973205 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05461791 0,08967175 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05461791 0,08961153 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,05461791 0,08955139 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05461791 0,08949132 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05461791 0,08943134 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05461791 0,08937144 ! prophase GO:0051324 17 11 0,000 0,05461791 0,08931162 ! neuroblast proliferation GO:0007405 25 11 0,000 0,05461791 0,08925188 ! nucleosome positioning GO:0016584 15 11 0,000 0,05461791 0,08919222 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05461791 0,08913264 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05461791 0,08907314 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05461791 0,08901372 ! acid secretion GO:0046717 20 11 0,000 0,05461791 0,08895438 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05461791 0,08889511 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05461791 0,08883593 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05461791 0,08877682 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05461791 0,0887178 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05461791 0,08865885 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,05461791 0,08859998 ! cholesterol efflux GO:0033344 21 11 0,000 0,05461791 0,08854118 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05461791 0,08848247 ! oocyte development GO:0048599 20 11 0,000 0,05461791 0,08842383 ! germ cell migration GO:0008354 26 11 0,000 0,05461791 0,08836527 ! embryonic gut development GO:0048566 19 11 0,000 0,05461791 0,08830679 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05461791 0,08824839 ! activation of innate immune response GO:0002218 16 11 0,000 0,05461791 0,08819006 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05461791 0,08813181 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05461791 0,08807364 ! lysogeny GO:0030069 22 11 0,000 0,05461791 0,08801554 GO:0019047|provirus integration, ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,05461791 0,08795752 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05461791 0,08789958 ! regulation of embryonic development GO:0045995 35 11 0,000 0,05461791 0,08784171 ! nucleus localization GO:0051647 22 11 0,000 0,05461791 0,08778392 ! organelle localization GO:0051640 155 74 1,000 0,05486749 0,08812707 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,05618704 0,09018722 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 1,000 0,05618704 0,090128 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,05751768 0,0922019 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,05751768 0,09214144 ! regulation of blood pressure GO:0008217 134 76 1,000 0,05751768 0,09208106 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,05885926 0,0941671 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,05943355 0,09502367 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,05943355 0,09496153 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,05943355 0,09489946 ! virus-host interaction GO:0019048 30 12 0,000 0,05943355 0,09483748 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,05943355 0,09477557 ! mating GO:0007618 17 12 0,000 0,05943355 0,09471375 ! protein complex disassembly GO:0043241 28 12 0,000 0,05943355 0,094652 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05943355 0,09459034 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,05943355 0,09452876 ! hippocampus development GO:0021766 29 12 0,000 0,05943355 0,09446726 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,05943355 0,09440584 ! T cell proliferation GO:0042098 32 12 0,000 0,05943355 0,09434449 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,05943355 0,09428323 ! ventral spinal cord development GO:0021517 25 12 0,000 0,05943355 0,09422205 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,05943355 0,09416094 ! drug transport GO:0015893 16 12 0,000 0,05943355 0,09409992 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,05943355 0,09403897 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,05943355 0,09397811 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,05943355 0,09391732 ! polyamine metabolic process GO:0006595 18 12 0,000 0,05943355 0,09385661 ! focal adhesion formation GO:0048041 37 12 0,000 0,05943355 0,09379598 ! mitotic spindle organization GO:0007052 23 12 0,000 0,05943355 0,09373543 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,05943355 0,09367495 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 21 12 0,000 0,05943355 0,09361455 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,05943355 0,09355424 ! entry into host cell GO:0030260 34 12 0,000 0,05943355 0,093494 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05943355 0,09343383 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,05943355 0,09337375 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,05943355 0,09331374 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05943355 0,09325381 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,05943355 0,09319395 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,05943355 0,09313417 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,05943355 0,09307447 ! snRNA metabolic process GO:0016073 30 12 0,000 0,05943355 0,09301485 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,05943355 0,0929553 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,05943355 0,09289583 ! fucose catabolic process GO:0019317 25 12 0,000 0,05943355 0,09283643 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,05943355 0,09277711 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,05943355 0,09271786 ! zymogen activation GO:0031638 18 12 0,000 0,05943355 0,09265869 ! T cell homeostasis GO:0043029 28 12 0,000 0,05943355 0,0925996 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,05943355 0,09254058 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,05943355 0,09248164 ! oocyte differentiation GO:0009994 21 12 0,000 0,05943355 0,09242277 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,05943355 0,09236398 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,05943355 0,09230526 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,05943355 0,09224662 ! defense response to fungus GO:0050832 15 12 0,000 0,05943355 0,09218805 ! developmental induction GO:0031128 22 12 0,000 0,05943355 0,09212955 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,05943355 0,09207113 ! response to cold GO:0009409 17 12 0,000 0,05943355 0,09201278 ! establishment of cell polarity GO:0030010 21 12 0,000 0,05943355 0,09195451 ! regulation of synapse organization GO:0050807 18 12 0,000 0,05943355 0,09189631 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,06157464 0,09514665 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,06157464 0,09508651 ! protein oligomerization GO:0051259 149 79 1,000 0,06157464 0,09502644 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,06294817 0,09708483 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0642248 0,09899129 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,0642248 0,09892887 ! regulation of chemokine production GO:0032642 18 13 0,000 0,0642248 0,09886653 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0642248 0,09880427 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,0642248 0,09874209 ! peroxisomal transport GO:0043574 28 13 0,000 0,0642248 0,09867999 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,0642248 0,09861797 ! cartilage condensation GO:0001502 22 13 0,000 0,0642248 0,09855602 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,0642248 0,09849415 ! organelle fusion GO:0048284 36 13 0,000 0,0642248 0,09843236 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,0642248 0,09837065 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,0642248 0,09830901 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,0642248 0,09824746 ! endocrine pancreas development GO:0031018 25 13 0,000 0,0642248 0,09818597 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,0642248 0,09812457 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,0642248 0,09806324 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,0642248 0,09800199 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,0642248 0,09794082 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,0642248 0,09787972 ! methionine metabolic process GO:0006555 31 13 0,000 0,0642248 0,0978187 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,0642248 0,09775775 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,0642248 0,09769688 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,0642248 0,09763608 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,0642248 0,09757536 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,0642248 0,09751472 ! cytokine metabolic process GO:0042107 24 13 0,000 0,0642248 0,09745415 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,0642248 0,09739366 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,0642248 0,09733324 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,0642248 0,0972729 ! L-glutamate transport GO:0015813 30 13 0,000 0,0642248 0,09721263 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,0642248 0,09715244 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,0642248 0,09709232 ! protein homotetramerization GO:0051289 24 13 0,000 0,0642248 0,09703227 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,0642248 0,0969723 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,0642248 0,09691241 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,0642248 0,09685258 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,0642248 0,09679284 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,0642248 0,09673316 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0642248 0,09667356 ! histone methylation GO:0016571 29 13 0,000 0,0642248 0,09661403 ! chromatin silencing GO:0006342 29 13 0,000 0,0642248 0,09655458 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,0642248 0,09649519 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,0642248 0,09643589 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,0642248 0,09637665 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,0642248 0,09631749 ! spleen development GO:0048536 24 13 0,000 0,0642248 0,0962584 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,0642248 0,09619938 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,0642248 0,09614043 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,0642248 0,09608156 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,0642248 0,09602276 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,0642248 0,09596403 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,0642248 0,09590537 ! insulin secretion GO:0030073 24 13 0,000 0,0642248 0,09584678 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,0642248 0,09578827 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,0642248 0,09572983 ! acrosome reaction GO:0007340 19 13 0,000 0,0642248 0,09567146 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,0642248 0,09561315 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,0642248 0,09555493 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,06572617 0,09772918 ! protein import into nucleus GO:0006606 174 82 1,000 0,06572617 0,09766974 ! nuclear import GO:0051170 177 83 1,000 0,06713038 0,09969575 ! response to metal ion GO:0010038 158 84 1,000 0,06854453 0,10173408 ! digestion GO:0007586 130 84 1,000 0,06854453 0,10167231 ! rRNA transcription GO:0009303 28 14 0,000 0,06899177 0,10227361 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06899177 0,10221158 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,06899177 0,10214964 ! water transport GO:0006833 21 14 0,000 0,06899177 0,10208777 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06899177 0,10202597 ! non-recombinational repair GO:0000726 29 14 0,000 0,06899177 0,10196425 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,06899177 0,1019026 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06899177 0,10184103 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06899177 0,10177953 ! palate development GO:0060021 32 14 0,000 0,06899177 0,10171811 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06899177 0,10165676 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06899177 0,10159548 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06899177 0,10153428 ! arginine metabolic process GO:0006525 21 14 0,000 0,06899177 0,10147315 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06899177 0,10141209 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06899177 0,10135111 ! fear response GO:0042596 34 14 0,000 0,06899177 0,10129021 ! organic alcohol transport GO:0015850 29 14 0,000 0,06899177 0,10122937 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06899177 0,10116861 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,06899177 0,10110792 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,06899177 0,1010473 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06899177 0,10098676 ! bone mineralization GO:0030282 18 14 0,000 0,06899177 0,10092629 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06899177 0,10086589 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06899177 0,10080556 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06899177 0,10074531 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,06899177 0,10068513 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06899177 0,10062502 ! regulation of cellular pH GO:0030641 27 14 0,000 0,06899177 0,10056498 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,06899177 0,10050501 ! ribosome assembly GO:0042255 18 14 0,000 0,06899177 0,10044511 ! cerebellum development GO:0021549 23 14 0,000 0,06899177 0,10038529 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06899177 0,10032554 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,06899177 0,10026585 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06899177 0,10020624 ! response to gamma radiation GO:0010332 30 14 0,000 0,06899177 0,1001467 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06899177 0,10008723 ! NADP metabolic process GO:0006739 24 14 0,000 0,06899177 0,10002783 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,06899177 0,09996851 ! oxygen transport GO:0015671 22 14 0,000 0,06899177 0,09990925 ! male genitalia development GO:0030539 26 14 0,000 0,06899177 0,09985006 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,06899177 0,09979094 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,06899177 0,09973189 ! negative regulation of growth GO:0045926 168 85 1,000 0,0699685 0,101084 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,07140214 0,10309423 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,07140214 0,10303334 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,07284533 0,10505381 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,0737346 0,10627352 ! lactation GO:0007595 30 15 0,000 0,0737346 0,10621086 ! reproductive cellular process GO:0048610 22 15 0,000 0,0737346 0,10614827 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,0737346 0,10608576 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,0737346 0,10602332 ! superoxide anion generation GO:0042554 22 15 0,000 0,0737346 0,10596095 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,0737346 0,10589866 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,0737346 0,10583644 ! copper ion transport GO:0006825 22 15 0,000 0,0737346 0,10577429 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,0737346 0,10571222 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,0737346 0,10565022 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,0737346 0,10558829 ! sulfate transport GO:0008272 27 15 0,000 0,0737346 0,10552643 ! response to cAMP GO:0051591 25 15 0,000 0,0737346 0,10546465 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,0737346 0,10540294 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,0737346 0,1053413 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,0737346 0,10527973 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,0737346 0,10521823 ! vesicle coating GO:0006901 38 15 0,000 0,0737346 0,10515681 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,0737346 0,10509546 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,0737346 0,10503418 ! regulation of exocytosis GO:0017157 26 15 0,000 0,0737346 0,10497297 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,0737346 0,10491183 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,0737346 0,10485077 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,0737346 0,10478977 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,0737346 0,10472885 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,0737346 0,10466799 ! regulation of vasodilation GO:0042312 27 15 0,000 0,0737346 0,10460721 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,0737346 0,1045465 ! histone deacetylation GO:0016575 24 15 0,000 0,0737346 0,10448586 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,0737346 0,10442529 ! cofactor transport GO:0051181 30 15 0,000 0,0737346 0,10436478 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,0737346 0,10430435 ! muscle maintenance GO:0046716 26 15 0,000 0,0737346 0,10424399 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,0737346 0,1041837 ! intestinal absorption GO:0050892 31 15 0,000 0,0737346 0,10412348 ! heme biosynthetic process GO:0006783 33 15 0,000 0,0737346 0,10406333 ! cell killing GO:0001906 32 15 0,000 0,0737346 0,10400324 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,0737346 0,10394323 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,0737346 0,10388329 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,0737346 0,10382341 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,0737346 0,1037636 ! actin filament polymerization GO:0030041 27 15 0,000 0,0737346 0,10370387 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,0737346 0,1036442 ! amine biosynthetic process GO:0009309 146 88 1,000 0,07429793 0,10437599 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,07575981 0,10636852 ! regulation of DNA binding GO:0051101 167 89 1,000 0,07575981 0,10630742 ! cellular defense response GO:0006968 123 89 1,000 0,07575981 0,1062464 ! protein localization in nucleus GO:0034504 192 89 1,000 0,07575981 0,10618544 ! response to inorganic substance GO:0010035 173 90 1,000 0,07723084 0,10818517 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,07845339 0,10983475 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,07845339 0,10977184 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,07845339 0,109709 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,07845339 0,10964624 ! bone remodeling GO:0046849 28 16 0,000 0,07845339 0,10958355 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,07845339 0,10952093 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,07845339 0,10945838 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07845339 0,10939591 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,07845339 0,1093335 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,07845339 0,10927117 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,07845339 0,10920891 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,07845339 0,10914671 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,07845339 0,10908459 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,07845339 0,10902254 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,07845339 0,10896056 ! protein polyubiquitination GO:0000209 41 16 0,000 0,07845339 0,10889865 ! glutamate metabolic process GO:0006536 25 16 0,000 0,07845339 0,10883682 ! response to osmotic stress GO:0006970 27 16 0,000 0,07845339 0,10877505 ! lysosomal transport GO:0007041 31 16 0,000 0,07845339 0,10871335 ! fructose metabolic process GO:0006000 25 16 0,000 0,07845339 0,10865172 ! L-amino acid transport GO:0015807 33 16 0,000 0,07845339 0,10859016 ! stem cell development GO:0048864 46 16 0,000 0,07845339 0,10852867 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07845339 0,10846725 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 36 16 0,000 0,07845339 0,1084059 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,07845339 0,10834462 ! axon cargo transport GO:0008088 46 16 0,000 0,07845339 0,10828341 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,07845339 0,10822227 ! DNA replication initiation GO:0006270 28 16 0,000 0,07845339 0,10816119 ! mRNA splice site selection GO:0006376 44 16 0,000 0,07845339 0,10810019 ! tissue regeneration GO:0042246 27 16 0,000 0,07845339 0,10803925 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,07845339 0,10797838 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,07845339 0,10791759 ! biomineral formation GO:0031214 22 16 0,000 0,07845339 0,10785686 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,07845339 0,10779619 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,07845339 0,1077356 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07845339 0,10767507 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,07845339 0,10761462 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,07845339 0,10755423 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,07845339 0,1074939 ! peptide hormone processing GO:0016486 27 16 0,000 0,07845339 0,10743365 ! ossification GO:0001503 205 91 1,000 0,07871088 0,10772588 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,07871088 0,10766556 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! bone development GO:0060348 206 92 1,000 0,08019982 0,10964083 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,08314828 0,11360808 ! metencephalon development GO:0022037 32 17 0,000 0,08314828 0,11354457 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,08314828 0,11348114 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,08314828 0,11341778 ! signal complex assembly GO:0007172 47 17 0,000 0,08314828 0,11335449 ! filopodium assembly GO:0046847 42 17 0,000 0,08314828 0,11329127 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08314828 0,11322812 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08314828 0,11316504 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,08314828 0,11310203 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08314828 0,11303909 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08314828 0,11297622 ! myoblast differentiation GO:0045445 50 17 0,000 0,08314828 0,11291342 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08314828 0,11285069 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,08314828 0,11278803 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08314828 0,11272544 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08314828 0,11266292 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,08314828 0,11260047 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,08314828 0,11253808 ! membrane budding GO:0006900 42 17 0,000 0,08314828 0,11247577 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08314828 0,11241353 ! regulation of protein binding GO:0043393 33 17 0,000 0,08314828 0,11235135 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,08314828 0,11228924 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08314828 0,1122272 ! genitalia development GO:0048806 32 17 0,000 0,08314828 0,11216523 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08314828 0,11210333 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,08314828 0,1120415 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08314828 0,11197974 ! steroid catabolic process GO:0006706 34 17 0,000 0,08314828 0,11191804 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,08314828 0,11185641 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,08314828 0,11179485 ! gas transport GO:0015669 26 17 0,000 0,08314828 0,11173336 ! organic cation transport GO:0015695 32 17 0,000 0,08314828 0,11167193 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08314828 0,11161057 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,08314828 0,11154928 ! female pregnancy GO:0007565 166 94 1,000 0,08320384 0,11156256 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,08471868 0,1135314 ! sex differentiation GO:0007548 171 96 1,000 0,08624191 0,11550931 ! regulation of T cell activation GO:0050863 175 96 1,000 0,08624191 0,11544602 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 0,08777339 0,11743176 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,08777339 0,11736749 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,08781938 0,11736474 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,08781938 0,11730057 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,08781938 0,11723647 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,08781938 0,11717244 ! heart looping GO:0001947 34 18 0,000 0,08781938 0,11710848 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,08781938 0,11704459 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,08781938 0,11698077 ! centrosome cycle GO:0007098 26 18 0,000 0,08781938 0,11691702 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,08781938 0,11685334 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,08781938 0,11678973 ! glycine metabolic process GO:0006544 30 18 0,000 0,08781938 0,11672619 ! glutamine metabolic process GO:0006541 29 18 0,000 0,08781938 0,11666272 ! response to retinoic acid GO:0032526 31 18 0,000 0,08781938 0,11659931 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,08781938 0,11653598 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,08781938 0,11647271 ! DNA integration GO:0015074 32 18 0,000 0,08781938 0,11640952 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,08781938 0,11634639 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,08781938 0,11628333 ! neural crest cell migration GO:0001755 41 18 0,000 0,08781938 0,11622033 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,08781938 0,11615741 ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,08781938 0,11609455 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,08781938 0,11603177 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,08781938 0,11596905 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,08781938 0,11590639 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,08781938 0,11584381 ! detection of bacterium GO:0016045 22 18 0,000 0,08781938 0,11578129 ! defense response to virus GO:0051607 43 18 0,000 0,08781938 0,11571884 ! microspike assembly GO:0030035 46 18 0,000 0,08781938 0,11565646 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,08781938 0,11559415 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,08781938 0,1155319 ! interphase of mitotic cell cycle GO:0051329 224 98 1,000 0,08931302 0,11743364 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,08931302 0,11737047 ! positive regulation of immune response GO:0050778 175 100 1,000 0,0924162 0,12138321 ! hormone metabolic process GO:0042445 171 100 1,000 0,0924162 0,12131799 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,09246681 0,12131923 ! negative regulation of defense response GO:0031348 27 19 0,000 0,09246681 0,12125411 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,09246681 0,12118906 ! neuron maturation GO:0042551 46 19 0,000 0,09246681 0,12112408 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,09246681 0,12105917 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,09246681 0,12099433 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,09246681 0,12092956 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,09246681 0,12086486 ! inositol metabolic process GO:0006020 33 19 0,000 0,09246681 0,12080022 ! memory GO:0007613 34 19 0,000 0,09246681 0,12073566 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,09246681 0,12067116 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,09246681 0,12060673 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,09246681 0,12054238 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,09246681 0,12047809 ! pigmentation during development GO:0048066 42 19 0,000 0,09246681 0,12041387 ! response to vitamin A GO:0033189 32 19 0,000 0,09246681 0,12034971 ! heme metabolic process GO:0042168 40 19 0,000 0,09246681 0,12028563 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,09246681 0,12022161 ! response to fungus GO:0009620 26 19 0,000 0,09246681 0,12015767 ! protein export from nucleus GO:0006611 40 19 0,000 0,09246681 0,12009379 ! heart process GO:0003015 32 19 0,000 0,09246681 0,12002998 GO:0060047|heart contraction, ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,09246681 0,11996623 ! visual learning GO:0008542 38 19 0,000 0,09246681 0,11990256 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,09246681 0,11983895 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,09246681 0,11977541 ! vitamin transport GO:0051180 31 19 0,000 0,09246681 0,11971193 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,09246681 0,11964852 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,09246681 0,11958519 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,09246681 0,11952191 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,09246681 0,11945871 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,09246681 0,11939557 ! cilium assembly GO:0042384 38 19 0,000 0,09246681 0,1193325 ! protein secretion GO:0009306 45 20 0,000 0,09709069 0,12523367 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,09709069 0,12516758 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,09709069 0,12510156 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,09709069 0,12503562 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,09709069 0,12496974 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,09709069 0,12490393 ! response to vitamin GO:0033273 36 20 0,000 0,09709069 0,12483819 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,09709069 0,12477252 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,09709069 0,12470692 ! bile acid metabolic process GO:0008206 34 20 0,000 0,09709069 0,12464139 ! retinoid metabolic process GO:0001523 34 20 0,000 0,09709069 0,12457593 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,09709069 0,12451053 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,09709069 0,12444521 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,09709069 0,12437995 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,09709069 0,12431476 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,09709069 0,12424964 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,09709069 0,12418459 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,09709069 0,1241196 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,09709069 0,12405469 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,09709069 0,12398984 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,09709069 0,12392506 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,09709069 0,12386035 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,09709069 0,1237957 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,09709069 0,12373112 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,09709069 0,12366661 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,09709069 0,12360217 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,09709069 0,12353779 ! regulation of cell killing GO:0031341 46 21 0,000 0,10169115 0,12932404 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,10169115 0,12925675 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,10169115 0,12918954 ! ovarian follicle development GO:0001541 39 21 0,000 0,10169115 0,12912239 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,10169115 0,12905531 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,10169115 0,12898831 ! plasma membrane fusion GO:0045026 33 21 0,000 0,10169115 0,12892137 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,10169115 0,1288545 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,10169115 0,1287877 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,10169115 0,12872097 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,10169115 0,12865431 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,10169115 0,12858772 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,10169115 0,1285212 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,10169115 0,12845475 ! collagen catabolic process GO:0030574 29 21 0,000 0,10169115 0,12838836 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,10169115 0,12832204 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,10169115 0,1282558 ! actin filament-based movement GO:0030048 47 21 0,000 0,10169115 0,12818962 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,10169115 0,12812351 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,10626829 0,13382136 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,10626829 0,13375242 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,10626829 0,13368354 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,10626829 0,13361474 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,10626829 0,13354601 ! microtubule-based transport GO:0010970 59 22 0,000 0,10626829 0,13347735 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,10626829 0,13340876 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,10626829 0,13334024 ! cellular response to starvation GO:0009267 37 22 0,000 0,10626829 0,13327179 ! vacuolar transport GO:0007034 41 22 0,000 0,10626829 0,13320341 ! central nervous system neuron development GO:0021954 47 22 0,000 0,10626829 0,1331351 ! fucose metabolic process GO:0006004 44 22 0,000 0,10626829 0,13306686 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,10626829 0,13299869 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,10626829 0,13293059 ! ureteric bud development GO:0001657 50 22 0,000 0,10626829 0,13286256 ! cell aging GO:0007569 48 22 0,000 0,10626829 0,1327946 ! stem cell differentiation GO:0048863 57 22 0,000 0,10626829 0,13272671 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,10626829 0,13265889 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,10626829 0,13259113 ! cytolysis GO:0019835 27 22 0,000 0,10626829 0,13252345 ! vasodilation GO:0042311 40 22 0,000 0,10626829 0,13245584 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,10626829 0,13238829 ! G1 phase GO:0051318 44 22 0,000 0,10626829 0,13232082 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,10626829 0,13225341 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,10626829 0,13218607 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,10626829 0,1321188 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,10626829 0,1320516 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,10626829 0,13198446 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,10626829 0,1319174 ! sarcomere organization GO:0045214 32 22 0,000 0,10626829 0,1318504 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,10626829 0,13178347 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,10626829 0,13171661 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,10626829 0,13164982 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,10626829 0,13158309 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,10626829 0,13151643 ! gut development GO:0048565 44 22 0,000 0,10626829 0,13144984 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,10626829 0,13138332 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,10626829 0,13131686 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,10626829 0,13125048 ! protein stabilization GO:0050821 41 22 0,000 0,10626829 0,13118415 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,11082224 0,13673674 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,11082224 0,13666772 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11082224 0,13659876 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11082224 0,13652988 ! gluconeogenesis GO:0006094 38 23 0,000 0,11082224 0,13646106 ! glycerol metabolic process GO:0006071 40 23 0,000 0,11082224 0,13639231 ! viral genome replication GO:0019079 44 23 0,000 0,11082224 0,13632364 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,11082224 0,13625503 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11082224 0,13618649 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11082224 0,13611802 ! regeneration GO:0031099 42 23 0,000 0,11082224 0,13604962 ! axis specification GO:0009798 43 23 0,000 0,11082224 0,13598129 ! visual behavior GO:0007632 46 23 0,000 0,11082224 0,13591302 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,11082224 0,13584483 ! response to ethanol GO:0045471 47 23 0,000 0,11082224 0,1357767 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11082224 0,13570864 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11082224 0,13564065 ! peroxisome organization GO:0007031 43 23 0,000 0,11082224 0,13557273 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,11082224 0,13550488 ! vesicle targeting GO:0006903 49 23 0,000 0,11082224 0,13543709 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,11082224 0,13536937 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11082224 0,13530172 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11082224 0,13523414 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11082224 0,13516662 ! DNA modification GO:0006304 36 23 0,000 0,11082224 0,13509917 ! fatty acid transport GO:0015908 47 23 0,000 0,11082224 0,13503179 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,11082224 0,13496448 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11082224 0,13489723 ! cell-cell recognition GO:0009988 28 23 0,000 0,11082224 0,13483005 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,11082224 0,13476294 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11082224 0,13469589 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,11535312 0,1401331 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,11535312 0,14006345 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,11535312 0,13999387 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,11535312 0,13992436 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,11535312 0,13985492 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,11535312 0,13978555 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,11535312 0,13971625 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,11535312 0,13964701 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,11535312 0,13957784 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,11535312 0,13950875 GO:0042278|purine nucleoside metabolic process, ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,11535312 0,13943972 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,11535312 0,13937076 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,11535312 0,13930186 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,11535312 0,13923304 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,11535312 0,13916428 ! oogenesis GO:0048477 44 24 0,000 0,11535312 0,13909559 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,11535312 0,13902697 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,11535312 0,13895842 ! platelet activation GO:0030168 41 24 0,000 0,11535312 0,13888993 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,11535312 0,13882151 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,11535312 0,13875316 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,11535312 0,13868488 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,11535312 0,13861666 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,11535312 0,13854851 ! regulation of amine transport GO:0051952 41 24 0,000 0,11535312 0,13848043 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,11535312 0,13841241 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,11986103 0,14375086 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,11986103 0,14368032 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,11986103 0,14360986 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,11986103 0,14353946 ! leukocyte adhesion GO:0007159 55 25 0,000 0,11986103 0,14346913 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,11986103 0,14339887 ! phototransduction GO:0007602 37 25 0,000 0,11986103 0,14332868 ! keratinization GO:0031424 37 25 0,000 0,11986103 0,14325856 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,11986103 0,14318851 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,11986103 0,14311852 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,11986103 0,14304861 ! chromosome condensation GO:0030261 48 25 0,000 0,11986103 0,14297876 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,11986103 0,14290898 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,11986103 0,14283927 ! interaction with host GO:0051701 66 25 0,000 0,11986103 0,14276963 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,11986103 0,14270005 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,11986103 0,14263054 ! immunoglobulin production GO:0002377 62 25 0,000 0,11986103 0,1425611 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,11986103 0,14249173 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,11986103 0,14242242 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,11986103 0,14235318 ! liver development GO:0001889 55 25 0,000 0,11986103 0,14228401 ! protein tetramerization GO:0051262 57 25 0,000 0,11986103 0,14221491 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,1243461 0,14746482 ! initiation of viral infection GO:0019059 60 26 0,000 0,1243461 0,14739327 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,1243461 0,14732179 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,1243461 0,14725038 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,1243461 0,14717903 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,1243461 0,14710776 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,1243461 0,14703656 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,1243461 0,14696542 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,1243461 0,14689435 ! digestive system process GO:0022600 49 26 0,000 0,1243461 0,14682336 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,1243461 0,14675243 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,1243461 0,14668157 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,1243461 0,14661077 ! osteoblast differentiation GO:0001649 63 26 0,000 0,1243461 0,14654005 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,1243461 0,14646939 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,1243461 0,14639881 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,1243461 0,14632829 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,1243461 0,14625784 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,1243461 0,14618745 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,1243461 0,14611714 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,1243461 0,14604689 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,1243461 0,14597671 ! blastocyst development GO:0001824 50 26 0,000 0,1243461 0,14590659 ! telomere organization GO:0032200 46 26 0,000 0,1243461 0,14583655 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,1243461 0,14576657 ! neural tube closure GO:0001843 58 26 0,000 0,1243461 0,14569665 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,1243461 0,14562681 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,1243461 0,14555703 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,12880844 0,15070834 ! embryonic pattern specification GO:0009880 49 27 0,000 0,12880844 0,1506362 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,12880844 0,15056412 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,12880844 0,15049212 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,12880844 0,15042018 ! iron ion transport GO:0006826 65 27 0,000 0,12880844 0,15034831 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,12880844 0,15027651 ! superoxide metabolic process GO:0006801 41 27 0,000 0,12880844 0,15020478 ! tube lumen formation GO:0035148 59 27 0,000 0,12880844 0,15013312 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,12880844 0,15006153 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,12880844 0,14999 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,12880844 0,14991854 ! response to starvation GO:0042594 47 27 0,000 0,12880844 0,14984715 ! response to toxin GO:0009636 49 27 0,000 0,12880844 0,14977583 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,12880844 0,14970458 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,12880844 0,14963339 ! leukocyte proliferation GO:0070661 59 27 0,000 0,12880844 0,14956227 GO:0032943|mononuclear cell proliferation, ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,13324816 0,15464383 ! neuron fate commitment GO:0048663 52 28 0,000 0,13324816 0,1545704 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,13324816 0,15449704 ! vesicle docking GO:0048278 55 28 0,000 0,13324816 0,15442375 ! circadian rhythm GO:0007623 56 28 0,000 0,13324816 0,15435053 ! fat cell differentiation GO:0045444 57 28 0,000 0,13324816 0,15427738 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,13324816 0,15420429 ! sperm motility GO:0030317 37 28 0,000 0,13324816 0,15413128 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,13324816 0,15405834 ! base-excision repair GO:0006284 41 28 0,000 0,13324816 0,15398546 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,13324816 0,15391265 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,13324816 0,15383992 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,13324816 0,15376725 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,13324816 0,15369465 ! glutathione metabolic process GO:0006749 42 28 0,000 0,13324816 0,15362212 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,13324816 0,15354965 ! lipid oxidation GO:0034440 48 28 0,000 0,13324816 0,15347726 GO:0019395|fatty acid oxidation, ! translational initiation GO:0006413 66 29 0,000 0,13766539 0,15849036 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,13766539 0,1584157 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,13766539 0,15834112 ! autophagy GO:0006914 47 29 0,000 0,13766539 0,15826661 ! primary neural tube formation GO:0014020 61 29 0,000 0,13766539 0,15819216 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,13766539 0,15811779 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,13766539 0,15804349 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,13766539 0,15796925 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,13766539 0,15789509 ! synaptogenesis GO:0007416 46 29 0,000 0,13766539 0,15782099 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,13766539 0,15774697 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,13766539 0,15767301 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,13766539 0,15759913 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,14206022 0,16255415 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,14206022 0,16247805 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,14206022 0,16240202 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,14206022 0,16232606 ! acute-phase response GO:0006953 50 30 0,000 0,14206022 0,16225017 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,14206022 0,16217436 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,14206022 0,16209861 ! myofibril assembly GO:0030239 50 30 0,000 0,14206022 0,16202293 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,14206022 0,16194733 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,14206022 0,16187179 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,14206022 0,16179633 ! cell fate determination GO:0001709 64 30 0,000 0,14206022 0,16172093 ! phospholipid transport GO:0015914 65 30 0,000 0,14206022 0,16164561 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,14206022 0,16157035 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,14206022 0,16149517 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,14206022 0,16142006 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,14206022 0,16134501 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,14206022 0,16127004 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,14206022 0,16119513 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,14643278 0,16607952 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,14643278 0,16600245 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,14643278 0,16592546 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,14643278 0,16584853 ! cell junction assembly GO:0034329 85 31 0,000 0,14643278 0,16577168 ! regulation of innate immune response GO:0045088 57 31 0,000 0,14643278 0,1656949 ! ovulation cycle process GO:0022602 55 31 0,000 0,14643278 0,16561819 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,14643278 0,16554155 ! detection of light stimulus GO:0009583 44 31 0,000 0,14643278 0,16546498 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,14643278 0,16538848 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,14643278 0,16531205 ! natural killer cell activation GO:0030101 50 31 0,000 0,14643278 0,1652357 ! cofactor catabolic process GO:0051187 54 31 0,000 0,14643278 0,16515941 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,14643278 0,1650832 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,14643278 0,16500705 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,15078318 0,16983094 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,15078318 0,16975268 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,15078318 0,16967448 ! spindle organization GO:0007051 50 32 0,000 0,15078318 0,16959637 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,15078318 0,16951832 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,15078318 0,16944034 ! muscle cell development GO:0055001 52 32 0,000 0,15078318 0,16936244 ! mesoderm formation GO:0001707 73 32 0,000 0,15078318 0,16928461 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,15078318 0,16920685 ! ovulation cycle GO:0042698 57 32 0,000 0,15078318 0,16912916 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,15078318 0,16905154 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,15078318 0,16897399 ! gene silencing GO:0016458 71 32 0,000 0,15078318 0,16889652 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,15511153 0,1736652 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,15511153 0,17358564 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,15511153 0,17350616 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,15511153 0,17342675 ! response to ionizing radiation GO:0010212 74 33 0,000 0,15511153 0,17334742 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,15511153 0,17326816 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,15511153 0,17318897 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,15511153 0,17310985 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,15511153 0,1730308 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,15941793 0,17775354 ! post-embryonic development GO:0009791 76 34 0,000 0,15941793 0,17767245 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,15941793 0,17759143 ! cholesterol transport GO:0030301 62 34 0,000 0,15941793 0,17751049 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,15941793 0,17742962 ! spliceosome assembly GO:0000245 75 34 0,000 0,15941793 0,17734882 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,15941793 0,1772681 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,15941793 0,17718745 ! formation of primary germ layer GO:0001704 76 34 0,000 0,15941793 0,17710687 ! cell fate specification GO:0001708 56 34 0,000 0,15941793 0,17702637 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,15941793 0,17694594 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,15941793 0,17686558 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,16370251 0,18153665 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,16370251 0,18145428 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,16370251 0,18137199 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,16370251 0,18128977 ! membrane docking GO:0022406 69 35 0,000 0,16370251 0,18120763 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,16370251 0,18112556 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,16370251 0,18104356 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,16370251 0,18096164 ! sterol transport GO:0015918 63 35 0,000 0,16370251 0,1808798 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,16796537 0,18550606 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,16796537 0,18542223 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,16796537 0,18533848 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,16796537 0,18525481 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,16796537 0,18517121 ! protein targeting to membrane GO:0006612 75 36 0,000 0,16796537 0,18508768 ! aerobic respiration GO:0009060 56 36 0,000 0,16796537 0,18500424 ! cytokine production GO:0001816 68 36 0,000 0,16796537 0,18492086 ! embryonic organ development GO:0048568 67 36 0,000 0,16796537 0,18483757 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,16796537 0,18475434 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,16796537 0,1846712 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,17220662 0,18924911 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,17220662 0,18916401 ! sister chromatid segregation GO:0000819 65 37 0,000 0,17220662 0,189079 ! odontogenesis GO:0042476 74 37 0,000 0,17220662 0,18899406 ! actomyosin structure organization GO:0031032 68 37 0,000 0,17220662 0,18890919 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,17220662 0,1888244 ! female gonad development GO:0008585 71 37 0,000 0,17220662 0,18873969 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,17220662 0,18865505 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,17642637 0,19319122 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,17642637 0,19310466 ! meiosis I GO:0007127 74 38 0,000 0,17642637 0,19301819 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,17642637 0,19293179 ! organic anion transport GO:0015711 82 38 0,000 0,17642637 0,19284546 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,17642637 0,19275922 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,17642637 0,19267305 ! spermatid development GO:0007286 69 38 0,000 0,17642637 0,19258696 ! glycogen metabolic process GO:0005977 63 38 0,000 0,17642637 0,19250094 ! pigment metabolic process GO:0042440 87 38 0,000 0,17642637 0,19241501 ! neural tube formation GO:0001841 79 38 0,000 0,17642637 0,19232914 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,18062472 0,19681811 ! negative regulation of binding GO:0051100 71 39 0,000 0,18062472 0,19673036 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,18062472 0,19664269 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,18062472 0,1965551 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,18062472 0,19646758 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,18062472 0,19638015 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,18062472 0,19629279 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,18062472 0,19620551 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,18062472 0,19611831 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 0,000 0,18062472 0,19603118 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,18480179 0,20047548 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,18480179 0,2003865 ! learning GO:0007612 82 40 0,000 0,18480179 0,2002976 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,18480179 0,20020877 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,18480179 0,20012003 ! mismatch repair GO:0006298 58 40 0,000 0,18480179 0,20003136 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,18480179 0,19994277 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,18480179 0,19985426 ! RNA export from nucleus GO:0006405 61 41 0,000 0,18895769 0,20425824 ! mRNA catabolic process GO:0006402 79 41 0,000 0,18895769 0,2041679 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,18895769 0,20407764 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,18895769 0,20398746 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,18895769 0,20389736 ! feeding behavior GO:0007631 69 41 0,000 0,18895769 0,20380734 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,18895769 0,2037174 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,18895769 0,20362754 ! spermatid differentiation GO:0048515 73 41 0,000 0,18895769 0,20353776 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,18895769 0,20344805 ! RNA modification GO:0009451 64 41 0,000 0,18895769 0,20335843 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,19309251 0,20771687 ! organic ether metabolic process GO:0018904 59 42 0,000 0,19309251 0,20762544 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,19309251 0,2075341 ! T cell differentiation GO:0030217 93 42 0,000 0,19309251 0,20744283 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,19309251 0,20735165 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,19309251 0,20726055 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,19720637 0,2115833 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,19720637 0,21149042 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,19720637 0,21139762 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,19720637 0,2113049 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,19720637 0,21121226 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,19720637 0,2111197 ! ion transmembrane transport GO:0034220 79 43 0,000 0,19720637 0,21102723 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,20129937 0,21531277 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,20129937 0,21521854 ! striated muscle contraction GO:0006941 85 44 0,000 0,20129937 0,2151244 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,20129937 0,21503033 ! double-strand break repair GO:0006302 85 44 0,000 0,20129937 0,21493635 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,20537162 0,21918867 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,20537162 0,21909296 ! biopolymer methylation GO:0043414 91 45 0,000 0,20537162 0,21899732 ! B cell differentiation GO:0030183 124 45 0,000 0,20537162 0,21890178 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,20537162 0,21880631 ! female gamete generation GO:0007292 71 45 0,000 0,20537162 0,21871093 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,20537162 0,21861563 ! polyol metabolic process GO:0019751 77 45 0,000 0,20537162 0,21852041 ! developmental growth GO:0048589 88 45 0,000 0,20537162 0,21842528 ! maintenance of location in cell GO:0051651 101 45 0,000 0,20537162 0,21833023 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,20942322 0,22254064 ! glycolysis GO:0006096 71 46 0,000 0,20942322 0,22244388 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,20942322 0,22234721 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,20942322 0,22225062 ! neural tube development GO:0021915 91 47 0,000 0,21345428 0,22643022 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,21746489 0,23058452 ! mitochondrial transport GO:0006839 94 48 0,000 0,21746489 0,23048448 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,21746489 0,23038453 ! endosome transport GO:0016197 127 48 0,000 0,21746489 0,23028467 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,21746489 0,23018489 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,21746489 0,2300852 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,21746489 0,2299856 ! methylation GO:0032259 97 48 0,000 0,21746489 0,22988608 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,22145517 0,23400302 ! JNK cascade GO:0007254 106 49 0,000 0,22145517 0,23390185 ! regulation of ion transport GO:0043269 86 50 0,000 0,22542521 0,23799213 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,22542521 0,23788932 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,22542521 0,23778661 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,22542521 0,23768398 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,22542521 0,23758144 ! viral infectious cycle GO:0019058 104 51 0,000 0,22937512 0,24164011 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,22937512 0,24153595 ! peptide metabolic process GO:0006518 80 51 0,000 0,22937512 0,24143189 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,23330499 0,24546257 ! Notch signaling pathway GO:0007219 111 52 0,000 0,23330499 0,24535691 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,23330499 0,24525133 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,23330499 0,24514585 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,23330499 0,24504045 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,23330499 0,24493515 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,23330499 0,24482994 ! amino acid activation GO:0043038 98 52 0,000 0,23330499 0,24472482 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,23721494 0,24871935 ! inner ear development GO:0048839 89 53 0,000 0,23721494 0,24861265 ! chromatin remodeling GO:0006338 122 53 0,000 0,23721494 0,24850604 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,23721494 0,24839953 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,23721494 0,2482931 ! regulation of translational initiation GO:0006446 87 54 0,000 0,24110505 0,25225681 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,24110505 0,25214882 ! membrane fusion GO:0006944 122 54 0,000 0,24110505 0,25204093 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,24110505 0,25193313 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,24110505 0,25182542 ! RNA catabolic process GO:0006401 103 55 0,000 0,24497544 0,25575855 ! cell maturation GO:0048469 107 55 0,000 0,24497544 0,2556493 ! glucose catabolic process GO:0006007 88 56 0,000 0,2488262 0,25955696 ! regulation of DNA replication GO:0006275 105 56 0,000 0,2488262 0,25944618 ! chloride transport GO:0006821 102 57 0,000 0,25265742 0,26332853 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,25265742 0,26321624 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,25646921 0,26707343 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,25646921 0,26695964 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,25646921 0,26684594 ! aging GO:0007568 112 58 0,000 0,25646921 0,26673234 ! maintenance of location GO:0051235 124 58 0,000 0,25646921 0,26661884 ! nuclear export GO:0051168 110 59 0,000 0,26026166 0,2704463 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,26403488 0,27425052 ! regulation of endocytosis GO:0030100 104 60 0,000 0,26403488 0,27413396 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,26403488 0,27401751 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,26778896 0,27779551 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,26778896 0,2776776 ! proton transport GO:0015992 117 61 0,000 0,26778896 0,27755979 ! viral reproductive process GO:0022415 132 62 0,000 0,27152399 0,28131175 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,27152399 0,2811925 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,27152399 0,28107335 ! tRNA processing GO:0008033 102 62 0,000 0,27152399 0,28095431 ! mesoderm development GO:0007498 128 63 0,000 0,27524008 0,28467888 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,27524008 0,28455841 ! hydrogen transport GO:0006818 121 64 0,000 0,27893731 0,28825882 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,27893731 0,28813694 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,27893731 0,28801515 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,28261579 0,29169006 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,28261579 0,29156688 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,28261579 0,2914438 GO:0048609|reproductive process in a multicellular organism, ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,2862756 0,29509338 ! chromosome segregation GO:0007059 127 67 0,000 0,28991685 0,29872074 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,28991685 0,2985948 ! secondary metabolic process GO:0019748 125 67 0,000 0,28991685 0,29846897 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,28991685 0,29834324 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,29353962 0,30194412 ! hexose catabolic process GO:0019320 113 68 0,000 0,29353962 0,30181704 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,29353962 0,30169007 ! viral reproduction GO:0016032 142 68 0,000 0,29353962 0,3015632 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,29714401 0,3051378 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,29714401 0,30500959 ! developmental maturation GO:0021700 128 69 0,000 0,29714401 0,30488149 ! single fertilization GO:0007338 83 69 0,000 0,29714401 0,30475349 ! cell redox homeostasis GO:0045454 114 70 0,000 0,30073011 0,308302 ! activation of immune response GO:0002253 120 70 0,000 0,30073011 0,30817268 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,30073011 0,30804346 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,30429802 0,3115675 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,30429802 0,31143697 ! B cell activation GO:0042113 179 72 0,000 0,30784782 0,31493811 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,30784782 0,31480628 ! humoral immune response GO:0006959 115 73 0,000 0,3113796 0,31828467 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,3113796 0,31815156 ! regulation of immune effector process GO:0002697 156 73 0,000 0,3113796 0,31801855 ! acute inflammatory response GO:0002526 118 74 0,000 0,31489347 0,32147294 ! amino acid transport GO:0006865 148 74 0,000 0,31489347 0,32133866 ! transition metal ion transport GO:0000041 143 75 0,000 0,3183895 0,32477058 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,3183895 0,32463504 ! rhythmic process GO:0048511 142 75 0,000 0,3183895 0,3244996 ! learning or memory GO:0007611 161 76 0,000 0,32186779 0,32790785 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,32186779 0,32777116 ! amine catabolic process GO:0009310 136 77 0,000 0,32532843 0,33115723 ! neurotransmitter transport GO:0006836 142 77 0,000 0,32532843 0,33101931 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,32532843 0,3308815 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,32532843 0,3307438 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,32877151 0,33410515 ! antigen processing and presentation GO:0019882 117 78 0,000 0,32877151 0,33396623 ! fertilization GO:0009566 99 78 0,000 0,32877151 0,33382743 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,32877151 0,33368874 ! meiosis GO:0007126 143 81 0,000 0,33899624 0,34392351 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,33899624 0,34378074 ! meiotic cell cycle GO:0051321 144 82 0,000 0,34236994 0,34705799 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,34572652 0,35031518 ! exocytosis GO:0006887 153 83 0,000 0,34572652 0,35016994 ! response to drug GO:0042493 149 83 0,000 0,34572652 0,35002482 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,34572652 0,34987982 ! inorganic anion transport GO:0015698 156 83 0,000 0,34572652 0,34973494 ! T cell activation GO:0042110 189 84 0,000 0,34906606 0,35296705 ! response to nutrient GO:0007584 135 84 0,000 0,34906606 0,35282101 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,35238865 0,35603204 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,35238865 0,35588486 ! regulation of lyase activity GO:0051339 169 86 0,000 0,35569438 0,35907494 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,35898332 0,36224546 ! alcohol catabolic process GO:0046164 142 87 0,000 0,35898332 0,36209589 ! nucleosome assembly GO:0006334 126 87 0,000 0,35898332 0,36194645 ! cellular respiration GO:0045333 143 88 0,000 0,36225556 0,36509503 ! sensory perception of smell GO:0007608 117 88 0,000 0,36225556 0,36494447 ! chromatin assembly GO:0031497 128 88 0,000 0,36225556 0,36479404 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,36225556 0,36464373 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,3687503 0,37102841 ! response to unfolded protein GO:0006986 139 90 0,000 0,3687503 0,37087566 ! defense response to bacterium GO:0042742 112 91 0,000 0,37197296 0,37396294 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,37517926 0,37703124 ! amine transport GO:0015837 181 93 0,000 0,37836928 0,38008065 ! vitamin metabolic process GO:0006766 153 93 0,000 0,37836928 0,37992444 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,3815431 0,3829539 ! sterol metabolic process GO:0016125 166 94 0,000 0,3815431 0,38279663 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,3815431 0,38263949 ! nucleosome organization GO:0034728 143 95 0,000 0,38470081 0,38564796 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,38470081 0,38548978 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,38470081 0,38533172 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,38470081 0,3851738 ! response to protein stimulus GO:0051789 158 96 0,000 0,38784248 0,38816026 ! leukocyte differentiation GO:0002521 232 98 0,000 0,39407805 0,39423942 ! mRNA transport GO:0051028 185 100 0,000 0,40025045 0,40025045