pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6721-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of phosphorylation GO:0042326 47 24 5,000 1,09E-09 2,622E-06 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 5,000 1,85E-09 2,226E-06 GO:0045936|negative regulation of phosphate metabolic process, ! induction of positive chemotaxis GO:0050930 15 9 3,000 5,377E-08 4,313E-05 ! induction of apoptosis by intracellular signals GO:0008629 93 45 5,000 6,09E-08 3,663E-05 ! insulin receptor signaling pathway GO:0008286 64 26 4,000 1,185E-07 5,703E-05 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 4,000 1,449E-07 5,811E-05 ! regulation of positive chemotaxis GO:0050926 19 12 3,000 2,09E-07 7,183E-05 GO:0050927|positive regulation of positive chemotaxis, ! interphase of mitotic cell cycle GO:0051329 209 95 6,000 3,018E-07 9,077E-05 ! interphase GO:0051325 213 98 6,000 3,736E-07 9,987E-05 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 3,000 4,196E-07 1,01E-04 ! cell cycle arrest GO:0007050 213 100 6,000 4,289E-07 9,382E-05 ! cellular response to insulin stimulus GO:0032869 82 37 4,000 7,54E-07 1,512E-04 ! blood coagulation GO:0007596 146 78 5,000 1,695E-06 3,137E-04 GO:0050817|coagulation, ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 1,988E-06 3,416E-04 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 4,000 2,293E-06 3,679E-04 ! response to insulin stimulus GO:0032868 95 46 4,000 2,293E-06 3,449E-04 ! positive regulation of locomotion GO:0040017 39 21 3,000 2,447E-06 3,463E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! hemostasis GO:0007599 158 84 5,000 2,623E-06 3,506E-04 ! apoptotic nuclear changes GO:0030262 32 22 3,000 2,98E-06 3,773E-04 ! regulation of chemotaxis GO:0050920 40 22 3,000 2,98E-06 3,584E-04 ! N-terminal protein amino acid acetylation GO:0006474 13 7 2,000 3,322E-06 3,806E-04 ! fibrinolysis GO:0042730 10 7 2,000 3,322E-06 3,633E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 3,322E-06 3,475E-04 ! regulation of behavior GO:0050795 43 24 3,000 4,297E-06 4,308E-04 ! ER overload response GO:0006983 12 8 2,000 5,297E-06 5,098E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 5,297E-06 4,902E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 5,297E-06 4,72E-04 ! negative regulation of protein modification process GO:0031400 60 28 3,000 8,162E-06 7,014E-04 ! response to peptide hormone stimulus GO:0043434 122 61 4,000 9,416E-06 7,812E-04 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 2,000 1,127E-05 9,042E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 1,127E-05 8,75E-04 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 1,127E-05 8,477E-04 ! negative regulation of protein kinase activity GO:0006469 130 67 4,000 1,495E-05 1,09E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 4,000 1,495E-05 1,058E-03 ! peptide or protein amino-terminal blocking GO:0018409 21 11 2,000 1,545E-05 1,062E-03 ! chondrocyte differentiation GO:0002062 24 11 2,000 1,545E-05 1,033E-03 ! negative regulation of glucose import GO:0046325 17 11 2,000 1,545E-05 1,005E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of kinase activity GO:0033673 131 68 4,000 1,608E-05 1,018E-03 ! regulation of B cell proliferation GO:0030888 20 12 2,000 2,053E-05 1,267E-03 ! histone acetylation GO:0016573 26 12 2,000 2,053E-05 1,235E-03 ! peptidyl-lysine modification GO:0018205 21 12 2,000 2,053E-05 1,205E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 2,053E-05 1,176E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of transferase activity GO:0051348 140 72 4,000 2,126E-05 1,19E-03 ! nucleus organization GO:0006997 67 38 3,000 2,839E-05 1,553E-03 ! positive regulation of phosphorylation GO:0042327 129 79 4,000 3,338E-05 1,784E-03 ! N-terminal protein amino acid modification GO:0031365 27 14 2,000 3,374E-05 1,765E-03 ! release of cytochrome c from mitochondria GO:0001836 30 14 2,000 3,374E-05 1,727E-03 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 4,000 3,766E-05 1,888E-03 GO:0045937|positive regulation of phosphate metabolic process, ! cellular response to hormone stimulus GO:0032870 167 82 4,000 3,996E-05 1,962E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 4,203E-05 2,023E-03 ! positive regulation of response to external stimulus GO:0032103 77 43 3,000 4,663E-05 2,2E-03 ! G1 phase of mitotic cell cycle GO:0000080 35 16 2,000 5,156E-05 2,385E-03 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 2,000 5,156E-05 2,34E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 5,156E-05 2,297E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 2,000 6,239E-05 2,729E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 6,239E-05 2,681E-03 ! neutrophil chemotaxis GO:0030593 27 17 2,000 6,239E-05 2,634E-03 ! negative regulation of blood coagulation GO:0030195 24 17 2,000 6,239E-05 2,588E-03 ! positive regulation of cell cycle GO:0045787 89 48 3,000 7,221E-05 2,945E-03 ! activation of caspase activity GO:0006919 84 48 3,000 7,221E-05 2,896E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 7,221E-05 2,848E-03 ! positive regulation of MAP kinase activity GO:0043406 160 93 4,000 7,309E-05 2,836E-03 ! negative regulation of multicellular organismal process GO:0051241 166 93 4,000 7,309E-05 2,791E-03 ! G1 phase GO:0051318 40 19 2,000 8,831E-05 3,32E-03 ! regulation of DNA metabolic process GO:0051052 178 97 4,000 8,93E-05 3,306E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 9,176E-05 3,345E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! skeletal muscle tissue development GO:0007519 186 99 4,000 9,838E-05 3,533E-03 GO:0060538|skeletal muscle organ development, ! regulation of angiogenesis GO:0045765 114 52 3,000 9,905E-05 3,505E-03 ! cartilage development GO:0051216 90 52 3,000 9,905E-05 3,454E-03 ! protein amino acid acetylation GO:0006473 39 20 2,000 1,035E-04 3,559E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 2,000 1,035E-04 3,509E-03 ! regulation of glucose import GO:0046324 29 20 2,000 1,035E-04 3,46E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 40 20 2,000 1,035E-04 3,413E-03 ! negative regulation of coagulation GO:0050819 29 20 2,000 1,035E-04 3,367E-03 ! response to UV GO:0009411 104 53 3,000 1,068E-04 3,425E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 1,204E-04 3,811E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 1,204E-04 3,762E-03 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 1,204E-04 3,714E-03 ! positive regulation of caspase activity GO:0043280 95 55 3,000 1,234E-04 3,76E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of DNA replication GO:0006275 101 56 3,000 1,325E-04 3,984E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 1,389E-04 4,127E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 3,000 1,42E-04 4,165E-03 ! positive regulation of cell migration GO:0030335 126 57 3,000 1,42E-04 4,115E-03 ! platelet activation GO:0030168 37 23 2,000 1,592E-04 4,561E-03 ! protein amino acid autophosphorylation GO:0046777 141 60 3,000 1,734E-04 4,908E-03 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 2,000 1,814E-04 5,074E-03 ! protein tetramerization GO:0051262 52 24 2,000 1,814E-04 5,016E-03 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 2,000 2,054E-04 5,616E-03 ! myelination GO:0042552 45 25 2,000 2,054E-04 5,553E-03 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 2,054E-04 5,491E-03 ! negative regulation of cell development GO:0010721 73 25 2,000 2,054E-04 5,431E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of blood coagulation GO:0030193 40 25 2,000 2,054E-04 5,372E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,096E-04 5,422E-03 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 2,096E-04 5,364E-03 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 1,000 2,096E-04 5,308E-03 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 1,000 2,096E-04 5,252E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 2,096E-04 5,198E-03 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 2,096E-04 5,145E-03 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 1,000 2,096E-04 5,093E-03 ! regulation of retroviral genome replication GO:0045091 7 5 1,000 2,096E-04 5,042E-03 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 2,096E-04 4,992E-03 ! microvillus organization GO:0032528 7 5 1,000 2,096E-04 4,943E-03 GO:0030033|microvillus assembly, ! muscle cell migration GO:0014812 8 5 1,000 2,096E-04 4,895E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 2,096E-04 4,848E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 2,096E-04 4,802E-03 ! enteric nervous system development GO:0048484 8 5 1,000 2,096E-04 4,757E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,096E-04 4,712E-03 ! stem cell division GO:0017145 11 5 1,000 2,096E-04 4,669E-03 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 1,000 2,096E-04 4,626E-03 ! positive regulation of cell motion GO:0051272 146 64 3,000 2,227E-04 4,871E-03 ! positive regulation of nuclear division GO:0051785 40 26 2,000 2,314E-04 5,016E-03 GO:0045840|positive regulation of mitosis, ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 2,595E-04 5,574E-03 ! protein amino acid acylation GO:0043543 55 27 2,000 2,595E-04 5,524E-03 ! regulation of chromosome organization GO:0033044 42 27 2,000 2,595E-04 5,476E-03 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 2,595E-04 5,428E-03 ! negative regulation of cell growth GO:0030308 132 67 3,000 2,658E-04 5,513E-03 ! lung development GO:0030324 144 67 3,000 2,658E-04 5,466E-03 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 2,896E-04 5,905E-03 ! negative regulation of cell size GO:0045792 134 69 3,000 2,977E-04 6,019E-03 ! urogenital system development GO:0001655 137 69 3,000 2,977E-04 5,968E-03 ! regulation of smooth muscle cell differentiation GO:0051150 9 6 1,000 3,134E-04 6,232E-03 ! attachment of GPI anchor to protein GO:0016255 15 6 1,000 3,134E-04 6,181E-03 ! male sex determination GO:0030238 15 6 1,000 3,134E-04 6,13E-03 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 3,134E-04 6,081E-03 ! establishment of spindle localization GO:0051293 12 6 1,000 3,134E-04 6,032E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 3,134E-04 5,984E-03 GO:0045686|negative regulation of glial cell differentiation, ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 3,134E-04 5,937E-03 ! negative regulation of B cell activation GO:0050869 13 6 1,000 3,134E-04 5,891E-03 ! respiratory tube development GO:0030323 150 70 3,000 3,146E-04 5,867E-03 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 3,219E-04 5,958E-03 ! regulation of coagulation GO:0050818 46 29 2,000 3,219E-04 5,913E-03 ! regulation of caspase activity GO:0043281 122 72 3,000 3,505E-04 6,388E-03 ! respiratory system development GO:0060541 153 72 3,000 3,505E-04 6,34E-03 ! cell junction assembly GO:0034329 78 30 2,000 3,565E-04 6,401E-03 ! ensheathment of neurons GO:0007272 57 30 2,000 3,565E-04 6,354E-03 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 3,565E-04 6,307E-03 ! regulation of B cell activation GO:0050864 50 30 2,000 3,565E-04 6,261E-03 ! regulation of endopeptidase activity GO:0052548 125 74 3,000 3,892E-04 6,786E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 4,326E-04 7,488E-03 ! regulation of helicase activity GO:0051095 15 7 1,000 4,374E-04 7,518E-03 ! prostate gland development GO:0030850 13 7 1,000 4,374E-04 7,464E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 4,374E-04 7,412E-03 ! mRNA stabilization GO:0048255 18 7 1,000 4,374E-04 7,36E-03 GO:0043489|RNA stabilization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 4,374E-04 7,309E-03 ! regulation of granule cell precursor proliferation GO:0021936 13 7 1,000 4,374E-04 7,258E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! wound healing, spreading of epidermal cells GO:0035313 14 7 1,000 4,374E-04 7,209E-03 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 4,374E-04 7,16E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 4,374E-04 7,111E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 4,374E-04 7,064E-03 ! response to tumor cell GO:0002347 13 7 1,000 4,374E-04 7,016E-03 ! regulation of respiratory burst GO:0060263 11 7 1,000 4,374E-04 6,97E-03 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 1,000 4,374E-04 6,924E-03 ! leukocyte chemotaxis GO:0030595 50 33 2,000 4,743E-04 7,458E-03 GO:0060326|cell chemotaxis, ! regulation of peptidase activity GO:0052547 134 79 3,000 4,993E-04 7,8E-03 ! response to hypoxia GO:0001666 171 81 3,000 5,489E-04 8,521E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 5,815E-04 8,968E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 5,815E-04 8,911E-03 ! negative regulation of muscle cell differentiation GO:0051148 15 8 1,000 5,815E-04 8,855E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 5,815E-04 8,799E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 5,815E-04 8,744E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 5,815E-04 8,69E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 5,815E-04 8,636E-03 ! positive regulation of insulin secretion GO:0032024 15 8 1,000 5,815E-04 8,583E-03 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 5,815E-04 8,531E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 5,815E-04 8,479E-03 ! DNA topological change GO:0006265 12 8 1,000 5,815E-04 8,428E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 5,815E-04 8,377E-03 ! response to oxygen levels GO:0070482 176 83 3,000 6,02E-04 8,621E-03 ! cell junction organization GO:0034330 86 36 2,000 6,144E-04 8,747E-03 ! negative regulation of cell activation GO:0050866 65 36 2,000 6,144E-04 8,696E-03 ! negative regulation of transport GO:0051051 153 84 3,000 6,298E-04 8,862E-03 ! negative regulation of growth GO:0045926 155 84 3,000 6,298E-04 8,81E-03 ! regulation of protein stability GO:0031647 73 37 2,000 6,664E-04 9,267E-03 ! tube morphogenesis GO:0035239 176 86 3,000 6,883E-04 9,517E-03 ! mitochondrion organization GO:0007005 148 86 3,000 6,883E-04 9,463E-03 ! regulation of protein transport GO:0051223 154 87 3,000 7,189E-04 9,827E-03 GO:0070201|regulation of establishment of protein localization, ! carbohydrate homeostasis GO:0033500 53 38 2,000 7,21E-04 9,801E-03 GO:0042593|glucose homeostasis, ! embryonic epithelial tube formation GO:0001838 72 38 2,000 7,21E-04 9,746E-03 ! regulation of developmental growth GO:0048638 15 9 1,000 7,454E-04 0,01001857 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 7,454E-04 9,963E-03 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 1,000 7,454E-04 9,908E-03 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 21 9 1,000 7,454E-04 9,853E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 7,454E-04 9,8E-03 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 1,000 7,454E-04 9,746E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 7,454E-04 9,694E-03 ! retinol metabolic process GO:0042572 18 9 1,000 7,454E-04 9,642E-03 ! motor axon guidance GO:0008045 16 9 1,000 7,454E-04 9,59E-03 ! protein heterooligomerization GO:0051291 16 9 1,000 7,454E-04 9,539E-03 ! musculoskeletal movement GO:0050881 14 9 1,000 7,454E-04 9,488E-03 GO:0050879|multicellular organismal movement, ! regulation of telomere maintenance GO:0032204 14 9 1,000 7,454E-04 9,439E-03 ! regulation of action potential in neuron GO:0019228 73 39 2,000 7,785E-04 9,807E-03 ! regulation of cell cycle process GO:0010564 149 90 3,000 8,165E-04 0,01023146 ! regulation of T cell proliferation GO:0042129 71 41 2,000 9,02E-04 0,01124436 ! T cell differentiation GO:0030217 81 41 2,000 9,02E-04 0,0111864 ! regulation of T cell differentiation GO:0045580 70 41 2,000 9,02E-04 0,01112904 ! regulation of membrane potential GO:0042391 164 93 3,000 9,231E-04 0,01133116 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 9,289E-04 0,01134454 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 9,289E-04 0,01128724 ! lung alveolus development GO:0048286 26 10 1,000 9,289E-04 0,01123052 ! negative regulation of striated muscle development GO:0045843 19 10 1,000 9,289E-04 0,01117437 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 9,289E-04 0,01111878 ! regulation of bone resorption GO:0045124 25 10 1,000 9,289E-04 0,01106373 ! regulation of gliogenesis GO:0014013 23 10 1,000 9,289E-04 0,01100923 GO:0045685|regulation of glial cell differentiation, ! DNA ligation GO:0006266 19 10 1,000 9,289E-04 0,01095527 ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 9,289E-04 0,01090183 ! positive regulation of viral reproduction GO:0048524 18 10 1,000 9,289E-04 0,0108489 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 9,289E-04 0,01079649 GO:0043470|regulation of carbohydrate catabolic process, ! natural killer cell mediated immunity GO:0002228 18 10 1,000 9,289E-04 0,01074459 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 9,289E-04 0,01069318 ! localization within membrane GO:0051668 20 10 1,000 9,289E-04 0,01064226 ! neuron migration GO:0001764 79 42 2,000 9,681E-04 0,01103907 ! regulation of protein secretion GO:0050708 71 42 2,000 9,681E-04 0,01098699 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 1,037E-03 0,01171607 ! regulation of protein localization GO:0032880 176 97 3,000 1,08E-03 0,01214192 ! negative regulation of muscle development GO:0048635 20 11 1,000 1,132E-03 0,01266629 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 1,132E-03 0,01260765 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,132E-03 0,01254955 ! blood vessel remodeling GO:0001974 29 11 1,000 1,132E-03 0,01249198 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 1,132E-03 0,01243494 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 22 11 1,000 1,132E-03 0,01237842 ! regulation of intracellular pH GO:0051453 19 11 1,000 1,132E-03 0,01232241 ! positive regulation of peptide secretion GO:0002793 22 11 1,000 1,132E-03 0,0122669 ! neuroblast proliferation GO:0007405 24 11 1,000 1,132E-03 0,01221189 ! regulation of leukocyte migration GO:0002685 26 11 1,000 1,132E-03 0,01215738 ! regulation of embryonic development GO:0045995 27 11 1,000 1,132E-03 0,01210334 ! leukocyte migration GO:0050900 68 45 2,000 1,185E-03 0,01261137 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 1,263E-03 0,0133867 ! positive regulation of protein transport GO:0051222 72 46 2,000 1,263E-03 0,01332799 ! positive regulation of defense response GO:0031349 76 47 2,000 1,345E-03 0,01412695 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 1,354E-03 0,01416532 ! virus-host interaction GO:0019048 29 12 1,000 1,354E-03 0,014104 ! cartilage condensation GO:0001502 20 12 1,000 1,354E-03 0,01404321 ! hippocampus development GO:0021766 26 12 1,000 1,354E-03 0,01398293 ! autonomic nervous system development GO:0048483 24 12 1,000 1,354E-03 0,01392318 ! leukocyte mediated cytotoxicity GO:0001909 26 12 1,000 1,354E-03 0,01386393 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 1,354E-03 0,01380519 ! cellular component disassembly GO:0022411 86 48 2,000 1,429E-03 0,01451123 ! morphogenesis of embryonic epithelium GO:0016331 91 48 2,000 1,429E-03 0,01445026 ! regulation of inflammatory response GO:0050727 75 48 2,000 1,429E-03 0,0143898 ! regulation of lymphocyte differentiation GO:0045619 81 48 2,000 1,429E-03 0,01432984 ! regulation of action potential GO:0001508 95 49 2,000 1,518E-03 0,01515004 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 1,518E-03 0,01508744 ! endocrine pancreas development GO:0031018 22 13 1,000 1,595E-03 0,01579735 ! plasma membrane organization GO:0007009 24 13 1,000 1,595E-03 0,01573261 ! cell-cell junction assembly GO:0007043 27 13 1,000 1,595E-03 0,01566839 ! response to X-ray GO:0010165 25 13 1,000 1,595E-03 0,0156047 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 1,595E-03 0,01554152 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of cellular pH GO:0030641 22 13 1,000 1,595E-03 0,01547885 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 1,595E-03 0,01541669 ! regulation of mRNA stability GO:0043488 31 13 1,000 1,595E-03 0,01535502 ! histone modification GO:0016570 91 50 2,000 1,609E-03 0,01542303 ! negative regulation of immune system process GO:0002683 95 50 2,000 1,609E-03 0,01536182 ! epithelial tube morphogenesis GO:0060562 98 51 2,000 1,704E-03 0,01620289 ! regulation of muscle contraction GO:0006937 81 52 2,000 1,802E-03 0,01706976 ! covalent chromatin modification GO:0016569 101 52 2,000 1,802E-03 0,01700282 ! retina development in camera-type eye GO:0060041 27 14 1,000 1,856E-03 0,01744148 ! response to gamma radiation GO:0010332 28 14 1,000 1,856E-03 0,01737362 ! regulation of RNA stability GO:0043487 32 14 1,000 1,856E-03 0,01730628 ! aging GO:0007568 103 55 2,000 2,118E-03 0,01967321 ! heart morphogenesis GO:0003007 97 55 2,000 2,118E-03 0,01959754 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 2,135E-03 0,01967964 ! heterophilic cell adhesion GO:0007157 39 15 1,000 2,135E-03 0,01960453 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 2,135E-03 0,01952999 ! G1/S transition checkpoint GO:0031575 40 15 1,000 2,135E-03 0,01945601 ! cell killing GO:0001906 29 15 1,000 2,135E-03 0,01938259 ! positive regulation of organelle organization GO:0010638 100 56 2,000 2,23E-03 0,02017194 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,432E-03 0,02191924 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 2,432E-03 0,02183745 ! activation of MAPKK activity GO:0000186 35 16 1,000 2,432E-03 0,02175627 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 2,432E-03 0,02167569 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 2,432E-03 0,02159571 ! skeletal system morphogenesis GO:0048705 105 59 2,000 2,589E-03 0,02290337 ! DNA catabolic process GO:0006308 86 59 2,000 2,589E-03 0,02281947 ! integrin-mediated signaling pathway GO:0007229 135 59 2,000 2,589E-03 0,02273619 ! regulation of heart contraction GO:0008016 110 60 2,000 2,716E-03 0,02376596 ! negative regulation of response to stimulus GO:0048585 100 60 2,000 2,716E-03 0,02367985 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 2,748E-03 0,02387273 ! limbic system development GO:0021761 36 17 1,000 2,748E-03 0,02378685 ! regulation of muscle cell differentiation GO:0051147 33 17 1,000 2,748E-03 0,0237016 ! regulation of viral genome replication GO:0045069 28 17 1,000 2,748E-03 0,02361695 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 1,000 2,748E-03 0,0235329 ! regulation of survival gene product expression GO:0045884 33 17 1,000 2,748E-03 0,02344945 ! cardiac muscle tissue development GO:0048738 31 17 1,000 2,748E-03 0,02336659 ! genitalia development GO:0048806 30 17 1,000 2,748E-03 0,02328432 ! neural crest cell migration GO:0001755 37 17 1,000 2,748E-03 0,02320262 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 2,748E-03 0,02312149 ! regulation of homeostatic process GO:0032844 134 62 2,000 2,982E-03 0,02499975 ! neuron maturation GO:0042551 42 18 1,000 3,083E-03 0,02575312 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 3,083E-03 0,02566401 ! memory GO:0007613 31 18 1,000 3,083E-03 0,02557551 ! response to retinoic acid GO:0032526 26 18 1,000 3,083E-03 0,02548762 ! cell-substrate junction assembly GO:0007044 54 18 1,000 3,083E-03 0,02540033 ! peptidyl-serine phosphorylation GO:0018105 38 18 1,000 3,083E-03 0,02531364 ! vitamin transport GO:0051180 27 18 1,000 3,083E-03 0,02522754 ! regulation of immunoglobulin production GO:0002637 43 18 1,000 3,083E-03 0,02514203 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 3,083E-03 0,02505709 ! regulation of mitosis GO:0007088 105 63 2,000 3,121E-03 0,02528103 GO:0051783|regulation of nuclear division, ! single fertilization GO:0007338 75 64 2,000 3,263E-03 0,02634692 ! positive regulation of hormone secretion GO:0046887 32 19 1,000 3,435E-03 0,02764039 ! lipid phosphorylation GO:0046834 35 19 1,000 3,435E-03 0,02754826 ! forelimb morphogenesis GO:0035136 32 19 1,000 3,435E-03 0,02745673 ! response to vitamin A GO:0033189 27 19 1,000 3,435E-03 0,02736582 ! neuromuscular junction development GO:0007528 34 19 1,000 3,435E-03 0,0272755 ! plasma membrane fusion GO:0045026 28 19 1,000 3,435E-03 0,02718578 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 3,435E-03 0,02709665 ! cell-cell junction organization GO:0045216 35 19 1,000 3,435E-03 0,0270081 ! embryonic organ morphogenesis GO:0048562 26 19 1,000 3,435E-03 0,02692012 ! activation of MAPK activity GO:0000187 115 67 2,000 3,715E-03 0,02901692 ! chromosome segregation GO:0007059 113 67 2,000 3,715E-03 0,02892302 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 3,805E-03 0,02953249 ! response to vitamin GO:0033273 31 20 1,000 3,805E-03 0,02943753 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 3,805E-03 0,02934318 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 1,000 3,805E-03 0,02924943 ! retinoid metabolic process GO:0001523 32 20 1,000 3,805E-03 0,02915628 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 1,000 3,805E-03 0,02906372 ! cellular response to starvation GO:0009267 33 20 1,000 3,805E-03 0,02897175 ! negative regulation of angiogenesis GO:0016525 45 20 1,000 3,805E-03 0,02888035 ! peptidyl-serine modification GO:0018209 43 20 1,000 3,805E-03 0,02878953 ! camera-type eye morphogenesis GO:0048593 42 20 1,000 3,805E-03 0,02869929 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 3,805E-03 0,0286096 ! cell cycle checkpoint GO:0000075 137 69 2,000 4,036E-03 0,03024754 ! hindlimb morphogenesis GO:0035137 43 21 1,000 4,193E-03 0,03133004 ! cell aging GO:0007569 44 21 1,000 4,193E-03 0,03123304 ! vitamin A metabolic process GO:0006776 33 21 1,000 4,193E-03 0,03113665 ! terpenoid metabolic process GO:0006721 37 21 1,000 4,193E-03 0,03104084 ! gut development GO:0048565 39 21 1,000 4,193E-03 0,03094562 ! reproductive structure development GO:0048608 113 71 2,000 4,373E-03 0,03217463 ! phosphoinositide metabolic process GO:0030384 128 72 2,000 4,548E-03 0,03335939 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 2,000 4,548E-03 0,03325799 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 4,598E-03 0,03352628 ! ureteric bud development GO:0001657 43 22 1,000 4,598E-03 0,033425 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 4,598E-03 0,03332432 ! positive regulation of B cell activation GO:0050871 38 22 1,000 4,598E-03 0,03322425 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 4,598E-03 0,03312477 ! learning or memory GO:0007611 147 73 2,000 4,727E-03 0,03394842 ! fertilization GO:0009566 90 73 2,000 4,727E-03 0,03384738 ! regulation of transcription factor activity GO:0051090 126 74 2,000 4,91E-03 0,03505546 GO:0090046|regulation of transcription regulator activity, ! positive regulation of DNA replication GO:0045740 43 23 1,000 5,021E-03 0,03574222 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 5,021E-03 0,03563679 ! gluconeogenesis GO:0006094 33 23 1,000 5,021E-03 0,03553197 ! leukocyte adhesion GO:0007159 50 23 1,000 5,021E-03 0,03542777 ! regulation of cell-matrix adhesion GO:0001952 78 23 1,000 5,021E-03 0,03532418 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 47 23 1,000 5,021E-03 0,0352212 ! sex determination GO:0007530 47 23 1,000 5,021E-03 0,03511881 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 5,021E-03 0,03501702 ! regulation of viral reproduction GO:0050792 38 23 1,000 5,021E-03 0,03491581 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 5,098E-03 0,03534541 ! lymphocyte differentiation GO:0030098 167 75 2,000 5,098E-03 0,03524384 ! regulation of catabolic process GO:0009894 161 76 2,000 5,289E-03 0,03646501 ! protein import into nucleus, translocation GO:0000060 46 24 1,000 5,461E-03 0,03754132 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 5,461E-03 0,03743436 ! regulation of cellular catabolic process GO:0031329 52 24 1,000 5,461E-03 0,03732802 ! digestive system process GO:0022600 39 24 1,000 5,461E-03 0,03722227 ! pallium development GO:0021543 49 24 1,000 5,461E-03 0,03711712 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 5,461E-03 0,03701257 ! protein oligomerization GO:0051259 139 78 2,000 5,686E-03 0,03842749 ! vasculogenesis GO:0001570 46 25 1,000 5,918E-03 0,0398853 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 5,918E-03 0,03977388 ! negative regulation of DNA replication GO:0008156 42 25 1,000 5,918E-03 0,03966309 ! chromosome condensation GO:0030261 45 25 1,000 5,918E-03 0,03955292 ! response to starvation GO:0042594 42 25 1,000 5,918E-03 0,03944335 ! neural crest cell development GO:0014032 54 25 1,000 5,918E-03 0,03933439 GO:0014033|neural crest cell differentiation, ! regulation of insulin secretion GO:0050796 37 25 1,000 5,918E-03 0,03922603 ! interaction with host GO:0051701 62 25 1,000 5,918E-03 0,03911827 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 5,918E-03 0,0390111 ! somitogenesis GO:0001756 43 25 1,000 5,918E-03 0,03890451 ! positive regulation of protein secretion GO:0050714 36 25 1,000 5,918E-03 0,0387985 ! cellular response to nutrient levels GO:0031669 41 25 1,000 5,918E-03 0,03869307 ! neural tube closure GO:0001843 49 25 1,000 5,918E-03 0,03858821 GO:0060606|tube closure, ! T cell activation GO:0042110 168 81 2,000 6,313E-03 0,04105281 ! pyruvate metabolic process GO:0006090 38 26 1,000 6,392E-03 0,04145348 ! tube lumen formation GO:0035148 50 26 1,000 6,392E-03 0,04134204 ! regulation of endothelial cell proliferation GO:0001936 57 26 1,000 6,392E-03 0,04123121 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 6,392E-03 0,04112096 ! response to drug GO:0042493 143 82 2,000 6,531E-03 0,04190352 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 6,883E-03 0,04404159 ! mitochondrial membrane organization GO:0007006 57 27 1,000 6,883E-03 0,04392477 ! primary neural tube formation GO:0014020 51 27 1,000 6,883E-03 0,04380857 ! base-excision repair GO:0006284 41 27 1,000 6,883E-03 0,04369298 ! glutathione metabolic process GO:0006749 39 27 1,000 6,883E-03 0,043578 ! fat-soluble vitamin metabolic process GO:0006775 40 27 1,000 6,883E-03 0,04346362 ! negative regulation of neuron differentiation GO:0045665 42 27 1,000 6,883E-03 0,04334984 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 7,39E-03 0,0464226 ! regulation of pH GO:0006885 43 29 1,000 7,913E-03 0,04958205 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 7,913E-03 0,04945326 ! regulation of peptide secretion GO:0002791 47 29 1,000 7,913E-03 0,04932515 ! regulation of production of molecular mediator of immune response GO:0002700 61 29 1,000 7,913E-03 0,04919769 ! tissue homeostasis GO:0001894 48 29 1,000 7,913E-03 0,04907089 GO:0048871|multicellular organismal homeostasis, ! positive regulation of protein modification process GO:0031401 136 88 2,000 7,932E-03 0,04906285 ! regulation of DNA binding GO:0051101 155 88 2,000 7,932E-03 0,04893705 ! gland development GO:0048732 206 88 2,000 7,932E-03 0,04881189 ! regulation of cell adhesion GO:0030155 212 89 2,000 8,182E-03 0,05021813 ! ossification GO:0001503 188 90 2,000 8,436E-03 0,05164524 ! sex differentiation GO:0007548 145 90 2,000 8,436E-03 0,05151416 ! neurotransmitter secretion GO:0007269 48 30 1,000 8,453E-03 0,05148912 ! eye morphogenesis GO:0048592 60 30 1,000 8,453E-03 0,0513591 ! bone development GO:0060348 189 91 2,000 8,694E-03 0,05269196 ! regulation of defense response GO:0031347 149 92 2,000 8,958E-03 0,05415059 ! GPI anchor biosynthetic process GO:0006506 53 31 1,000 9,009E-03 0,05432472 ! iron ion homeostasis GO:0055072 54 31 1,000 9,009E-03 0,05418891 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 9,009E-03 0,05405378 GO:0043433|negative regulation of transcription factor activity, ! regulation of T cell activation GO:0050863 158 94 2,000 9,498E-03 0,0568454 ! response to hydrogen peroxide GO:0042542 50 32 1,000 9,581E-03 0,05719904 ! GPI anchor metabolic process GO:0006505 56 32 1,000 9,581E-03 0,05705745 ! spindle organization GO:0007051 46 32 1,000 9,581E-03 0,05691657 ! metanephros development GO:0001656 74 32 1,000 9,581E-03 0,05677638 ! response to ionizing radiation GO:0010212 65 32 1,000 9,581E-03 0,05663688 ! response to mechanical stimulus GO:0009612 57 32 1,000 9,581E-03 0,05649807 ! hexose biosynthetic process GO:0019319 48 32 1,000 9,581E-03 0,05635993 ! peripheral nervous system development GO:0007422 64 32 1,000 9,581E-03 0,05622247 ! positive regulation of catabolic process GO:0009896 64 32 1,000 9,581E-03 0,05608567 ! forebrain development GO:0030900 188 95 2,000 9,775E-03 0,05708401 ! leukocyte differentiation GO:0002521 202 96 2,000 0,01005679 0,05858748 ! DNA damage checkpoint GO:0000077 71 33 1,000 0,01016823 0,05909364 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,01016823 0,05895125 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01077135 0,06229774 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 0,01077135 0,06214835 ! regulation of muscle development GO:0048634 70 35 1,000 0,01138991 0,06556009 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,01138991 0,06540362 ! negative regulation of secretion GO:0051048 63 35 1,000 0,01138991 0,0652479 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,01138991 0,06509291 ! negative regulation of cell adhesion GO:0007162 81 35 1,000 0,01138991 0,06493866 ! telencephalon development GO:0021537 68 35 1,000 0,01138991 0,06478514 ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 0,01138991 0,06463235 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,01138991 0,06448027 ! neural tube formation GO:0001841 67 35 1,000 0,01138991 0,06432891 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,01202376 0,06774981 ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,01202376 0,06759151 ! regulation of proteolysis GO:0030162 72 36 1,000 0,01202376 0,06743396 ! androgen receptor signaling pathway GO:0030521 74 36 1,000 0,01202376 0,06727713 ! embryonic organ development GO:0048568 57 36 1,000 0,01202376 0,06712104 ! monosaccharide biosynthetic process GO:0046364 52 36 1,000 0,01202376 0,06696566 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 1,000 0,01267275 0,0704172 ! meiosis I GO:0007127 65 37 1,000 0,01267275 0,07025495 ! sister chromatid segregation GO:0000819 58 37 1,000 0,01267275 0,07009344 ! tissue remodeling GO:0048771 76 37 1,000 0,01267275 0,06993268 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,01267275 0,06977265 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,01267275 0,06961335 ! glycogen metabolic process GO:0005977 61 37 1,000 0,01267275 0,06945478 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,01333674 0,07292771 ! phosphoinositide biosynthetic process GO:0046489 67 38 1,000 0,01333674 0,07276234 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 0,01333674 0,07259772 ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,01333674 0,07243384 GO:0046660|female sex differentiation, ! isoprenoid metabolic process GO:0006720 66 38 1,000 0,01333674 0,0722707 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 0,01333674 0,0721083 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 62 38 1,000 0,01333674 0,07194662 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 86 39 1,000 0,01401556 0,07543946 ! ear morphogenesis GO:0042471 60 39 1,000 0,01401556 0,07527107 ! segmentation GO:0035282 67 39 1,000 0,01401556 0,07510343 ! cytokinesis GO:0000910 72 40 1,000 0,01470907 0,07864452 ! regulation of hormone secretion GO:0046883 62 40 1,000 0,01470907 0,07847014 ! negative regulation of binding GO:0051100 72 40 1,000 0,01470907 0,07829654 ! mesenchymal cell development GO:0014031 87 40 1,000 0,01470907 0,0781237 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,01613958 0,08553268 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 67 42 1,000 0,01613958 0,0853447 ! alcohol biosynthetic process GO:0046165 59 42 1,000 0,01613958 0,08515754 ! regulation of intracellular protein transport GO:0033157 80 42 1,000 0,01613958 0,0849712 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,01687628 0,08865576 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,01687628 0,08846261 ! neural tube development GO:0021915 77 43 1,000 0,01687628 0,0882703 ! double-strand break repair GO:0006302 81 44 1,000 0,01762709 0,09199735 ! B cell differentiation GO:0030183 107 44 1,000 0,01762709 0,09179822 ! developmental growth GO:0048589 82 44 1,000 0,01762709 0,09159995 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,01839186 0,09536812 ! branching morphogenesis of a tube GO:0048754 97 45 1,000 0,01839186 0,09516302 ! cell growth GO:0016049 84 45 1,000 0,01839186 0,09495881 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 1,000 0,01917044 0,09876677 ! pigmentation GO:0043473 100 46 1,000 0,01917044 0,09855573 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,0199627 0,10240993 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,0199627 0,10219204 ! mitochondrial transport GO:0006839 82 48 1,000 0,0207685 0,1060913 ! protein amino acid lipidation GO:0006497 95 49 1,000 0,02158769 0,11004232 ! peptide metabolic process GO:0006518 76 49 1,000 0,02158769 0,10980967 ! endocrine system development GO:0035270 104 49 1,000 0,02158769 0,109578 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,02158769 0,10934731 ! neuromuscular process GO:0050905 99 50 1,000 0,02242013 0,11332529 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02286614 0,11533739 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02286614 0,11509609 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02286614 0,11485581 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02286614 0,11461653 ! neuron fate determination GO:0048664 7 5 0,000 0,02286614 0,11437824 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02286614 0,11414094 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02286614 0,11390462 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,02286614 0,11366928 ! polyol transport GO:0015791 12 5 0,000 0,02286614 0,11343491 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02286614 0,11320151 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02286614 0,11296906 ! response to superoxide GO:0000303 10 5 0,000 0,02286614 0,11273757 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02286614 0,11250702 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02286614 0,11227741 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02286614 0,11204874 ! female meiosis GO:0007143 7 5 0,000 0,02286614 0,111821 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02286614 0,11159418 ! cobalt ion transport GO:0006824 11 5 0,000 0,02286614 0,11136829 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02286614 0,1111433 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02286614 0,11091922 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02286614 0,11069604 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02286614 0,11047376 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02286614 0,11025237 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02286614 0,11003187 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02286614 0,10981224 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02286614 0,10959349 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02286614 0,10937561 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02286614 0,1091586 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02286614 0,10894244 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02286614 0,10872714 ! negative chemotaxis GO:0050919 14 5 0,000 0,02286614 0,10851269 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02286614 0,10829908 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02286614 0,10808631 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02286614 0,10787438 ! behavioral response to pain GO:0048266 9 5 0,000 0,02286614 0,10766327 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02286614 0,10745299 ! Notch receptor processing GO:0007220 8 5 0,000 0,02286614 0,10724353 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02286614 0,10703489 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02286614 0,10682705 ! micturition GO:0060073 9 5 0,000 0,02286614 0,10662002 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02286614 0,1064138 ! copulation GO:0007620 9 5 0,000 0,02286614 0,10620836 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02286614 0,10600372 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02286614 0,10579987 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02286614 0,1055968 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02286614 0,10539451 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02286614 0,10519299 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02286614 0,10499224 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02286614 0,10479225 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02286614 0,10459303 ! grooming behavior GO:0007625 6 5 0,000 0,02286614 0,10439456 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02286614 0,10419684 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02286614 0,10399987 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02286614 0,10380365 ! response to protozoan GO:0001562 10 5 0,000 0,02286614 0,10360816 ! lymph vessel development GO:0001945 10 5 0,000 0,02286614 0,10341341 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02286614 0,10321939 ! endochondral ossification GO:0001958 16 5 0,000 0,02286614 0,10302609 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02286614 0,10283352 ! parathyroid gland development GO:0060017 13 5 0,000 0,02286614 0,10264167 ! anagen GO:0042640 6 5 0,000 0,02286614 0,10245053 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02286614 0,1022601 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02286614 0,10207038 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02286614 0,10188136 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02286614 0,10169304 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02286614 0,10150541 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,02286614 0,10131848 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,02286614 0,10113223 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02286614 0,10094667 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02286614 0,10076178 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02286614 0,10057757 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,02286614 0,10039404 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02286614 0,10021117 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02286614 0,10002897 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02286614 0,09984743 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02286614 0,09966655 ! histidine catabolic process GO:0006548 6 5 0,000 0,02286614 0,09948632 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02286614 0,09930674 ! valine metabolic process GO:0006573 10 5 0,000 0,02286614 0,09912781 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,02286614 0,09894952 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02286614 0,09877187 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02286614 0,09859486 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02286614 0,09841848 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02286614 0,09824274 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02286614 0,09806762 ! polyol catabolic process GO:0046174 7 5 0,000 0,02286614 0,09789312 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02286614 0,09771924 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02286614 0,09754598 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02286614 0,09737333 ! mitochondrial fission GO:0000266 8 5 0,000 0,02286614 0,09720129 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02286614 0,09702986 ! mRNA transcription GO:0009299 9 5 0,000 0,02286614 0,09685904 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02286614 0,09668881 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02286614 0,09651918 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,02286614 0,09635015 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02286614 0,0961817 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02286614 0,09601384 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02286614 0,09584657 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02286614 0,09567988 ! response to food GO:0032094 6 5 0,000 0,02286614 0,09551377 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02286614 0,09534824 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02286614 0,09518327 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02286614 0,09501888 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02286614 0,09485506 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,02286614 0,09469179 ! forebrain neuron development GO:0021884 13 5 0,000 0,02286614 0,09452909 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02286614 0,09436695 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,02286614 0,09420536 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02286614 0,09404433 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02286614 0,09388384 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02286614 0,09372391 ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,02286614 0,09356451 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02286614 0,09340566 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02286614 0,09324734 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02286614 0,09308956 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02286614 0,09293232 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02286614 0,0927756 ! basic amino acid transport GO:0015802 11 5 0,000 0,02286614 0,09261942 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02286614 0,09246375 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,02286614 0,09230861 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02286614 0,09215399 ! depyrimidination GO:0045008 10 5 0,000 0,02286614 0,09199989 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02286614 0,0918463 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02286614 0,09169322 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02286614 0,09154065 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02286614 0,09138859 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02286614 0,09123704 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02286614 0,09108598 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02286614 0,09093543 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02286614 0,09078537 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02286614 0,0906358 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02286614 0,09048673 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02286614 0,09033815 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02286614 0,09019005 ! response to arsenic GO:0046685 10 5 0,000 0,02286614 0,09004244 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,02286614 0,08989532 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02286614 0,08974867 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02286614 0,0896025 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,02286614 0,0894568 ! response to cadmium ion GO:0046686 7 5 0,000 0,02286614 0,08931158 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02286614 0,08916683 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02286614 0,08902255 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02286614 0,08887873 ! decidualization GO:0046697 11 5 0,000 0,02286614 0,08873538 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02286614 0,08859248 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02286614 0,08845005 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02286614 0,08830808 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02286614 0,08816656 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02286614 0,08802549 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02286614 0,08788488 ! neural tube patterning GO:0021532 7 5 0,000 0,02286614 0,08774471 ! embryonic cleavage GO:0040016 6 5 0,000 0,02286614 0,08760499 ! peroxisome fission GO:0016559 5 5 0,000 0,02286614 0,08746571 ! histone demethylation GO:0016577 10 5 0,000 0,02286614 0,08732688 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02286614 0,08718848 ! mitotic recombination GO:0006312 9 5 0,000 0,02286614 0,08705053 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02286614 0,08691301 ! metaphase plate congression GO:0051310 7 5 0,000 0,02286614 0,08677592 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02286614 0,08663926 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02286614 0,08650304 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02286614 0,08636724 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02286614 0,08623187 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02286614 0,08609692 ! muscle cell proliferation GO:0033002 11 5 0,000 0,02286614 0,0859624 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02286614 0,08582829 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,02286614 0,0856946 ! plasminogen activation GO:0031639 5 5 0,000 0,02286614 0,08556133 ! B cell homeostasis GO:0001782 13 5 0,000 0,02286614 0,08542847 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02286614 0,08529602 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02286614 0,08516398 ! metaphase GO:0051323 8 5 0,000 0,02286614 0,08503235 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02286614 0,08490113 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02286614 0,08477031 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02286614 0,0846399 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02286614 0,08450988 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02286614 0,08438027 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02286614 0,08425105 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02286614 0,08412222 ! response to redox state GO:0051775 5 5 0,000 0,02286614 0,08399379 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02286614 0,08386575 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02286614 0,0837381 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02286614 0,08361084 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02286614 0,08348396 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02286614 0,08335747 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02286614 0,08323137 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02286614 0,08310564 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02286614 0,08298029 ! striatum development GO:0021756 9 5 0,000 0,02286614 0,08285532 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,02286614 0,08273073 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02286614 0,08260651 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02286614 0,08248266 ! glial cell migration GO:0008347 11 5 0,000 0,02286614 0,08235918 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02286614 0,08223607 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,02286614 0,08211333 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02286614 0,08199096 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02286614 0,08186895 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02286614 0,0817473 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02286614 0,08162601 ! neuroprotection GO:0043526 6 5 0,000 0,02286614 0,08150509 ! neural plate development GO:0001840 8 5 0,000 0,02286614 0,08138452 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02286614 0,0812643 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02286614 0,08114444 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02286614 0,08102494 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02286614 0,08090578 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02286614 0,08078698 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02286614 0,08066852 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02286614 0,08055041 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02286614 0,08043265 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02286614 0,08031523 ! spindle assembly GO:0051225 6 5 0,000 0,02286614 0,08019815 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02286614 0,08008142 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02286614 0,07996502 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02286614 0,07984896 ! drug metabolic process GO:0017144 6 5 0,000 0,02286614 0,07973324 ! organ regeneration GO:0031100 7 5 0,000 0,02286614 0,07961785 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02286614 0,07950279 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02286614 0,07938807 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02286614 0,07927368 ! positive regulation of binding GO:0051099 78 51 1,000 0,0232657 0,08054283 ! embryonic skeletal system development GO:0048706 85 51 1,000 0,0232657 0,08042711 ! chromatin remodeling GO:0006338 109 51 1,000 0,0232657 0,08031172 ! regulation of cell shape GO:0008360 125 51 1,000 0,0232657 0,08019666 ! membrane fusion GO:0006944 110 52 1,000 0,02412424 0,0830371 ! positive regulation of growth GO:0045927 90 52 1,000 0,02412424 0,08291847 ! morphogenesis of a branching structure GO:0001763 111 52 1,000 0,02412424 0,08280019 ! synapse organization GO:0050808 85 52 1,000 0,02412424 0,08268224 ! lipoprotein biosynthetic process GO:0042158 101 53 1,000 0,02499564 0,08554694 ! cell maturation GO:0048469 100 53 1,000 0,02499564 0,08542542 ! regulation of neuron apoptosis GO:0043523 100 53 1,000 0,02499564 0,08530425 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,02587974 0,08819639 GO:0010863|positive regulation of phospholipase C activity, ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 1,000 0,02587974 0,08807164 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,02677642 0,09099443 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,02677642 0,09086609 ! regulation of protein catabolic process GO:0042176 116 55 1,000 0,02677642 0,09073811 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02737669 0,09264179 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02737669 0,09251167 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,02737669 0,09238192 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02737669 0,09225254 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02737669 0,09212351 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,02737669 0,09199485 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,02737669 0,09186654 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02737669 0,09173859 ! sleep GO:0030431 13 6 0,000 0,02737669 0,091611 ! response to oxygen radical GO:0000305 11 6 0,000 0,02737669 0,09148376 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,02737669 0,09135688 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,02737669 0,09123035 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,02737669 0,09110416 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,02737669 0,09097833 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02737669 0,09085284 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02737669 0,0907277 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,02737669 0,0906029 ! forebrain regionalization GO:0021871 8 6 0,000 0,02737669 0,09047845 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02737669 0,09035433 ! male meiosis GO:0007140 7 6 0,000 0,02737669 0,09023056 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02737669 0,09010713 ! response to zinc ion GO:0010043 9 6 0,000 0,02737669 0,08998403 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02737669 0,08986127 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,02737669 0,08973884 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,02737669 0,08961675 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02737669 0,08949499 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02737669 0,08937356 ! malate metabolic process GO:0006108 11 6 0,000 0,02737669 0,08925245 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,02737669 0,08913168 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,02737669 0,08901123 ! protein refolding GO:0042026 15 6 0,000 0,02737669 0,08889111 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02737669 0,08877131 ! opsonization GO:0008228 8 6 0,000 0,02737669 0,08865183 ! mating behavior GO:0007617 7 6 0,000 0,02737669 0,08853267 ! neuron remodeling GO:0016322 15 6 0,000 0,02737669 0,08841384 ! erythrocyte maturation GO:0043249 7 6 0,000 0,02737669 0,08829532 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,02737669 0,08817712 ! equilibrioception GO:0050957 14 6 0,000 0,02737669 0,08805924 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,02737669 0,08794167 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,02737669 0,08782441 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02737669 0,08770747 GO:0046530|photoreceptor cell differentiation, ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02737669 0,08759084 ! response to interferon-gamma GO:0034341 15 6 0,000 0,02737669 0,08747452 ! toxin metabolic process GO:0009404 11 6 0,000 0,02737669 0,0873585 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02737669 0,08724279 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02737669 0,08712739 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,02737669 0,0870123 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,02737669 0,08689751 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,02737669 0,08678302 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,02737669 0,08666883 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02737669 0,08655494 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,02737669 0,08644135 ! thymic T cell selection GO:0045061 12 6 0,000 0,02737669 0,08632806 ! protein lipoylation GO:0009249 10 6 0,000 0,02737669 0,08621507 ! cysteine metabolic process GO:0006534 10 6 0,000 0,02737669 0,08610237 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02737669 0,08598996 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02737669 0,08587785 ! glutamate catabolic process GO:0006538 10 6 0,000 0,02737669 0,08576603 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,02737669 0,0856545 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02737669 0,08554326 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,02737669 0,08543231 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,02737669 0,08532165 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02737669 0,08521127 ! hyperosmotic response GO:0006972 9 6 0,000 0,02737669 0,08510118 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,02737669 0,08499137 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,02737669 0,08488184 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02737669 0,0847726 ! urea metabolic process GO:0019627 7 6 0,000 0,02737669 0,08466364 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02737669 0,08455496 ! neutrophil activation GO:0042119 8 6 0,000 0,02737669 0,08444655 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02737669 0,08433843 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,02737669 0,08423058 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02737669 0,084123 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02737669 0,0840157 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02737669 0,08390868 ! neuron apoptosis GO:0051402 9 6 0,000 0,02737669 0,08380192 ! nucleoside salvage GO:0043174 9 6 0,000 0,02737669 0,08369544 GO:0006166|purine ribonucleoside salvage, ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02737669 0,08358923 ! T cell mediated immunity GO:0002456 16 6 0,000 0,02737669 0,08348328 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02737669 0,08337761 GO:0010543|regulation of platelet activation, ! carnitine transport GO:0015879 10 6 0,000 0,02737669 0,0832722 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,02737669 0,08316706 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,02737669 0,08306218 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,02737669 0,08295757 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,02737669 0,08285322 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02737669 0,08274913 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,02737669 0,08264531 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,02737669 0,08254174 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,02737669 0,08243844 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,02737669 0,08233539 ! monocyte differentiation GO:0030224 12 6 0,000 0,02737669 0,0822326 ! neural nucleus development GO:0048857 14 6 0,000 0,02737669 0,08213006 ! response to UV-C GO:0010225 11 6 0,000 0,02737669 0,08202778 ! astrocyte development GO:0014002 15 6 0,000 0,02737669 0,08192576 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,02737669 0,08182399 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02737669 0,08172247 ! interaction with symbiont GO:0051702 13 6 0,000 0,02737669 0,0816212 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02737669 0,08152019 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02737669 0,08141942 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,02737669 0,0813189 ! response to copper ion GO:0046688 10 6 0,000 0,02737669 0,08121863 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,02737669 0,08111861 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,02737669 0,08101883 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02737669 0,0809193 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02737669 0,08082001 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02737669 0,08072097 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,02737669 0,08062217 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02737669 0,08052361 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,02737669 0,08042529 ! hair follicle maturation GO:0048820 7 6 0,000 0,02737669 0,08032721 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02737669 0,08022937 ! Schwann cell development GO:0014044 15 6 0,000 0,02737669 0,08013176 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,02737669 0,0800344 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02737669 0,07993727 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,02737669 0,07984038 ! subpallium development GO:0021544 10 6 0,000 0,02737669 0,07974372 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,02737669 0,07964729 ! histone ubiquitination GO:0016574 8 6 0,000 0,02737669 0,0795511 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,02737669 0,07945514 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02737669 0,07935941 ! G2 phase GO:0051319 16 6 0,000 0,02737669 0,07926391 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,02737669 0,07916864 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02737669 0,0790736 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,02737669 0,07897879 ! membrane to membrane docking GO:0022614 14 6 0,000 0,02737669 0,0788842 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02737669 0,07878984 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,02737669 0,07869571 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02737669 0,0786018 ! receptor internalization GO:0031623 10 6 0,000 0,02737669 0,07850812 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,02737669 0,07841465 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,02737669 0,07832142 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02737669 0,0782284 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,02737669 0,0781356 ! protein deubiquitination GO:0016579 14 6 0,000 0,02737669 0,07804302 ! protein destabilization GO:0031648 9 6 0,000 0,02737669 0,07795066 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02737669 0,07785852 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,02737669 0,0777666 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02737669 0,07767489 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,02737669 0,0775834 ! progesterone metabolic process GO:0042448 10 6 0,000 0,02737669 0,07749213 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,02737669 0,07740107 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,02737669 0,07731022 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,02737669 0,07721959 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,02737669 0,07712917 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02737669 0,07703896 ! determination of adult lifespan GO:0008340 15 6 0,000 0,02737669 0,07694896 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,02737669 0,07685917 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,02737669 0,07676959 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02737669 0,07668022 ! catecholamine transport GO:0051937 9 6 0,000 0,02737669 0,07659106 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,02737669 0,0765021 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02737669 0,07641335 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02737669 0,07632481 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,02737669 0,07623647 ! maternal placenta development GO:0001893 12 6 0,000 0,02737669 0,07614834 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,02737669 0,0760604 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02737669 0,07597268 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,02737669 0,07588515 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02737669 0,07579783 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,02737669 0,0757107 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,02737669 0,07562378 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,02768554 0,07638922 ! nucleotide-excision repair GO:0006289 83 56 1,000 0,02768554 0,07630172 ! regulation of bone remodeling GO:0046850 137 57 1,000 0,02860697 0,07875099 ! muscle fiber development GO:0048747 112 57 1,000 0,02860697 0,07866099 ! lipid modification GO:0030258 97 57 1,000 0,02860697 0,07857119 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,02860697 0,0784816 ! regulation of intracellular transport GO:0032386 101 57 1,000 0,02860697 0,07839222 ! regulation of tissue remodeling GO:0034103 140 58 1,000 0,02954058 0,08085852 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,02954058 0,08076663 ! positive regulation of secretion GO:0051047 95 59 1,000 0,03048624 0,08325754 ! establishment of organelle localization GO:0051656 109 59 1,000 0,03048624 0,08316315 ! regulation of neurotransmitter levels GO:0001505 97 60 1,000 0,03144382 0,08567818 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,03144382 0,08558126 ! camera-type eye development GO:0043010 116 60 1,000 0,03144382 0,08548456 ! kidney development GO:0001822 122 60 1,000 0,03144382 0,08538808 ! tRNA transcription GO:0009304 14 7 0,000 0,03186656 0,0864385 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03186656 0,08634116 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03186656 0,08624404 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03186656 0,08614714 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,03186656 0,08605045 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03186656 0,08595398 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03186656 0,08585773 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03186656 0,08576169 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03186656 0,08566587 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03186656 0,08557026 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03186656 0,08547486 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03186656 0,08537968 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03186656 0,08528471 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03186656 0,08518995 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03186656 0,08509539 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03186656 0,08500105 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,03186656 0,08490692 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03186656 0,084813 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03186656 0,08471928 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03186656 0,08462577 ! glycolipid transport GO:0046836 10 7 0,000 0,03186656 0,08453247 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03186656 0,08443937 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,03186656 0,08434648 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03186656 0,08425379 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03186656 0,08416131 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03186656 0,08406902 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03186656 0,08397694 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03186656 0,08388507 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03186656 0,08379339 ! pericardium development GO:0060039 14 7 0,000 0,03186656 0,08370191 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03186656 0,08361063 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03186656 0,08351955 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,03186656 0,08342867 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03186656 0,08333799 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03186656 0,0832475 ! lipoprotein transport GO:0042953 14 7 0,000 0,03186656 0,08315721 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03186656 0,08306712 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03186656 0,08297722 ! rhythmic behavior GO:0007622 15 7 0,000 0,03186656 0,08288751 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03186656 0,082798 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03186656 0,08270868 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03186656 0,08261956 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03186656 0,08253062 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03186656 0,08244188 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03186656 0,08235333 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03186656 0,08226497 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03186656 0,0821768 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03186656 0,08208881 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03186656 0,08200102 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03186656 0,08191341 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03186656 0,08182599 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03186656 0,08173875 ! spinal cord patterning GO:0021511 13 7 0,000 0,03186656 0,0816517 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,03186656 0,08156484 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03186656 0,08147816 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03186656 0,08139167 ! adrenal gland development GO:0030325 17 7 0,000 0,03186656 0,08130536 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03186656 0,08121923 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03186656 0,08113328 ! ovulation GO:0030728 9 7 0,000 0,03186656 0,08104752 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03186656 0,08096193 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03186656 0,08087653 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03186656 0,08079131 ! microtubule nucleation GO:0007020 20 7 0,000 0,03186656 0,08070626 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03186656 0,0806214 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03186656 0,08053671 ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03186656 0,0804522 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03186656 0,08036787 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03186656 0,08028372 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03186656 0,08019974 ! galactose metabolic process GO:0006012 13 7 0,000 0,03186656 0,08011594 ! vesicle fusion GO:0006906 17 7 0,000 0,03186656 0,08003231 ! response to dietary excess GO:0002021 8 7 0,000 0,03186656 0,07994885 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03186656 0,07986557 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03186656 0,07978247 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03186656 0,07969953 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03186656 0,07961677 ! organ growth GO:0035265 15 7 0,000 0,03186656 0,07953418 ! purine salvage GO:0043101 10 7 0,000 0,03186656 0,07945176 ! nucleoside transport GO:0015858 8 7 0,000 0,03186656 0,07936951 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03186656 0,07928744 ! parturition GO:0007567 14 7 0,000 0,03186656 0,07920553 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,03186656 0,07912379 ! rRNA modification GO:0000154 14 7 0,000 0,03186656 0,07904222 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03186656 0,07896081 ! spindle checkpoint GO:0031577 15 7 0,000 0,03186656 0,07887958 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03186656 0,07879851 ! macrophage differentiation GO:0030225 11 7 0,000 0,03186656 0,07871761 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03186656 0,07863687 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03186656 0,0785563 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,03186656 0,0784759 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03186656 0,07839565 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03186656 0,07831558 ! eating behavior GO:0042755 7 7 0,000 0,03186656 0,07823566 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03186656 0,07815591 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03186656 0,07807632 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03186656 0,0779969 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03186656 0,07791763 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03186656 0,07783853 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03186656 0,07775958 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,03186656 0,0776808 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03186656 0,07760218 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03186656 0,07752371 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03186656 0,0774454 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03186656 0,07736726 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03186656 0,07728926 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03186656 0,07721143 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03186656 0,07713375 ! regulation of meiosis GO:0040020 12 7 0,000 0,03186656 0,07705623 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03186656 0,07697887 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,03186656 0,07690166 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03186656 0,0768246 ! oxygen homeostasis GO:0032364 12 7 0,000 0,03186656 0,0767477 ! transcription termination GO:0006353 13 7 0,000 0,03186656 0,07667095 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03186656 0,07659436 ! anaphase GO:0051322 17 7 0,000 0,03186656 0,07651791 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,03186656 0,07644163 ! axonal fasciculation GO:0007413 18 7 0,000 0,03186656 0,07636549 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,03186656 0,0762895 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03186656 0,07621367 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,03186656 0,07613798 ! diuresis GO:0030146 12 7 0,000 0,03186656 0,07606245 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03186656 0,07598707 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03186656 0,07591183 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03186656 0,07583675 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03186656 0,07576181 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03186656 0,07568702 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03186656 0,07561238 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03186656 0,07553788 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03186656 0,07546353 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03186656 0,07538933 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03186656 0,07531528 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03186656 0,07524136 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03186656 0,0751676 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03186656 0,07509398 ! lymph node development GO:0048535 10 7 0,000 0,03186656 0,0750205 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,03186656 0,07494717 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03186656 0,07487398 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,03186656 0,07480093 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03186656 0,07472802 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03186656 0,07465526 ! adult feeding behavior GO:0008343 9 7 0,000 0,03186656 0,07458264 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03186656 0,07451016 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03186656 0,07443782 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03186656 0,07436562 ! muscle adaptation GO:0043500 14 7 0,000 0,03186656 0,07429356 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03186656 0,07422164 ! retina homeostasis GO:0001895 12 7 0,000 0,03186656 0,07414986 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03186656 0,07407821 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03186656 0,07400671 ! protein prenylation GO:0018342 18 7 0,000 0,03186656 0,07393534 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,03186656 0,07386411 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,03186656 0,07379302 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03186656 0,07372207 ! glycerophospholipid biosynthetic process GO:0046474 105 61 1,000 0,03241319 0,07491464 ! ear development GO:0043583 103 62 1,000 0,03339423 0,07710798 ! viral reproductive process GO:0022415 126 62 1,000 0,03339423 0,07703405 ! detection of external stimulus GO:0009581 91 63 1,000 0,0343868 0,07924775 ! steroid hormone receptor signaling pathway GO:0030518 129 63 1,000 0,0343868 0,07917192 ! lymphocyte mediated immunity GO:0002449 114 64 1,000 0,03539079 0,08140558 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,03633586 0,0834996 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,03633586 0,08341992 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,03633586 0,0833404 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,03633586 0,08326103 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,03633586 0,08318181 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03633586 0,08310274 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03633586 0,08302382 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,03633586 0,08294505 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,03633586 0,08286643 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,03633586 0,08278795 ! meiotic prophase I GO:0007128 13 8 0,000 0,03633586 0,08270963 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03633586 0,08263146 ! oligopeptide transport GO:0006857 15 8 0,000 0,03633586 0,08255343 ! UTP metabolic process GO:0046051 8 8 0,000 0,03633586 0,08247555 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,03633586 0,08239781 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,03633586 0,08232023 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,03633586 0,08224278 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03633586 0,08216549 ! succinate metabolic process GO:0006105 14 8 0,000 0,03633586 0,08208834 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03633586 0,08201133 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,03633586 0,08193447 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03633586 0,08185775 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03633586 0,08178118 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,03633586 0,08170475 ! reflex GO:0060004 16 8 0,000 0,03633586 0,08162846 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,03633586 0,08155231 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,03633586 0,08147631 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03633586 0,08140045 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,03633586 0,08132473 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,03633586 0,08124915 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,03633586 0,08117371 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03633586 0,0810984 ! pigment granule organization GO:0048753 16 8 0,000 0,03633586 0,08102324 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,03633586 0,08094822 ! astrocyte differentiation GO:0048708 18 8 0,000 0,03633586 0,08087334 ! histidine metabolic process GO:0006547 16 8 0,000 0,03633586 0,0807986 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03633586 0,08072399 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,03633586 0,08064952 ! glycine catabolic process GO:0006546 13 8 0,000 0,03633586 0,08057519 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,03633586 0,08050099 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,03633586 0,08042694 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,03633586 0,08035302 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,03633586 0,08027923 ! melanin metabolic process GO:0006582 15 8 0,000 0,03633586 0,08020558 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,03633586 0,08013206 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03633586 0,08005868 ! macrophage activation GO:0042116 12 8 0,000 0,03633586 0,07998543 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03633586 0,07991232 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,03633586 0,07983934 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,03633586 0,0797665 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,03633586 0,07969378 ! osteoblast development GO:0002076 16 8 0,000 0,03633586 0,0796212 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,03633586 0,07954875 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,03633586 0,07947644 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,03633586 0,07940425 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,03633586 0,0793322 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,03633586 0,07926027 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03633586 0,07918848 ! response to UV-B GO:0010224 16 8 0,000 0,03633586 0,07911681 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,03633586 0,07904528 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03633586 0,07897388 ! intermediate filament organization GO:0045109 12 8 0,000 0,03633586 0,0789026 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,03633586 0,07883145 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,03633586 0,07876043 ! cellular extravasation GO:0045123 12 8 0,000 0,03633586 0,07868954 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,03633586 0,07861878 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,03633586 0,07854814 ! response to antibiotic GO:0046677 11 8 0,000 0,03633586 0,07847763 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,03633586 0,07840725 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,03633586 0,07833699 ! response to tropane GO:0014073 15 8 0,000 0,03633586 0,07826686 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,03633586 0,07819685 ! melanosome transport GO:0032402 13 8 0,000 0,03633586 0,07812697 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,03633586 0,07805721 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03633586 0,07798758 ! mast cell activation GO:0045576 14 8 0,000 0,03633586 0,07791808 ! multicellular organismal aging GO:0010259 18 8 0,000 0,03633586 0,07784869 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,03633586 0,07777943 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,03633586 0,07771029 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,03633586 0,07764128 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03633586 0,07757239 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03633586 0,07750362 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,03633586 0,07743497 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03633586 0,07736644 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03633586 0,07729804 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,03633586 0,07722975 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,03633586 0,07716159 ! intracellular lipid transport GO:0032365 13 8 0,000 0,03633586 0,07709355 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03633586 0,07702562 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03633586 0,07695782 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,03633586 0,07689013 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,03633586 0,07682257 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03633586 0,07675512 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,03633586 0,07668779 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,03633586 0,07662058 ! hormone catabolic process GO:0042447 17 8 0,000 0,03633586 0,07655349 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03633586 0,07648651 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,03633586 0,07641965 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,03633586 0,07635291 ! ATP catabolic process GO:0006200 11 8 0,000 0,03633586 0,07628628 ! blastocyst growth GO:0001832 19 8 0,000 0,03633586 0,07621977 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03633586 0,07615338 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03633586 0,0760871 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,03633586 0,07602094 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03633586 0,07595489 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03633586 0,07588896 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,03633586 0,07582314 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,03633586 0,07575744 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,03633586 0,07569184 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,03633586 0,07562637 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,03633586 0,075561 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,03633586 0,07549575 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03633586 0,07543061 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,03633586 0,07536559 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03633586 0,07530067 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03633586 0,07523587 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,03633586 0,07517118 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,03640606 0,07525171 GO:0035113|embryonic appendage morphogenesis, ! secondary metabolic process GO:0019748 116 66 1,000 0,0374325 0,07730694 ! developmental maturation GO:0021700 116 66 1,000 0,0374325 0,07724064 ! cell projection assembly GO:0030031 120 66 1,000 0,0374325 0,07717446 ! cellular hormone metabolic process GO:0034754 113 67 1,000 0,03846997 0,07924551 ! adaptive immune response GO:0002250 119 67 1,000 0,03846997 0,07917772 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,03951837 0,08126597 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 1,000 0,03951837 0,08119658 ! viral reproduction GO:0016032 134 68 1,000 0,03951837 0,08112729 ! regulation of lipase activity GO:0060191 130 68 1,000 0,03951837 0,08105813 ! glycerolipid biosynthetic process GO:0045017 118 69 1,000 0,04057756 0,08315979 ! axon extension GO:0048675 15 9 0,000 0,04078467 0,08351313 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,04078467 0,08344211 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,04078467 0,08337122 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,04078467 0,08330045 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04078467 0,08322979 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,04078467 0,08315926 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,04078467 0,08308884 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,04078467 0,08301855 ! phosphate transport GO:0006817 19 9 0,000 0,04078467 0,08294837 ! reproductive behavior GO:0019098 19 9 0,000 0,04078467 0,08287831 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04078467 0,08280838 ! CTP metabolic process GO:0046036 9 9 0,000 0,04078467 0,08273855 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,04078467 0,08266885 ! GTP metabolic process GO:0046039 9 9 0,000 0,04078467 0,08259926 ! RNA methylation GO:0001510 15 9 0,000 0,04078467 0,08252979 ! elastic fiber assembly GO:0048251 15 9 0,000 0,04078467 0,08246044 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,04078467 0,0823912 ! artery development GO:0060840 24 9 0,000 0,04078467 0,08232208 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,04078467 0,08225308 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,04078467 0,08218419 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,04078467 0,08211542 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,04078467 0,08204676 ! chemosensory behavior GO:0007635 20 9 0,000 0,04078467 0,08197822 ! microtubule bundle formation GO:0001578 21 9 0,000 0,04078467 0,08190979 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,04078467 0,08184147 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04078467 0,08177327 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,04078467 0,08170518 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,04078467 0,08163721 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,04078467 0,08156935 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04078467 0,0815016 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04078467 0,08143396 ! protein targeting to ER GO:0045047 22 9 0,000 0,04078467 0,08136644 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,04078467 0,08129903 ! T cell selection GO:0045058 23 9 0,000 0,04078467 0,08123173 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,04078467 0,08116454 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04078467 0,08109746 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,04078467 0,08103049 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04078467 0,08096363 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04078467 0,08089689 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04078467 0,08083025 ! mannose metabolic process GO:0006013 13 9 0,000 0,04078467 0,08076372 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,04078467 0,08069731 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,04078467 0,080631 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,04078467 0,0805648 ! receptor clustering GO:0043113 18 9 0,000 0,04078467 0,08049871 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,04078467 0,08043273 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04078467 0,08036685 ! ruffle organization GO:0031529 15 9 0,000 0,04078467 0,08030108 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,04078467 0,08023543 ! behavioral fear response GO:0001662 22 9 0,000 0,04078467 0,08016987 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,04078467 0,08010443 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,04078467 0,08003909 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,04078467 0,07997386 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,04078467 0,07990873 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,04078467 0,07984371 ! segment specification GO:0007379 13 9 0,000 0,04078467 0,0797788 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04078467 0,07971399 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,04078467 0,07964929 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04078467 0,07958469 ! response to amine stimulus GO:0014075 13 9 0,000 0,04078467 0,0795202 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04078467 0,07945581 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,04078467 0,07939152 ! erythrocyte development GO:0048821 15 9 0,000 0,04078467 0,07932734 ! gas homeostasis GO:0033483 16 9 0,000 0,04078467 0,07926327 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04078467 0,07919929 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,04078467 0,07913542 ! renal water homeostasis GO:0003091 14 9 0,000 0,04078467 0,07907166 ! postreplication repair GO:0006301 22 9 0,000 0,04078467 0,07900799 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,04078467 0,07894443 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,04078467 0,07888097 ! icosanoid secretion GO:0032309 15 9 0,000 0,04078467 0,07881761 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,04078467 0,07875435 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04078467 0,0786912 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,04078467 0,07862814 ! regulation of cell division GO:0051302 15 9 0,000 0,04078467 0,07856519 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,04078467 0,07850234 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,04078467 0,07843959 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04078467 0,07837694 ! sterol catabolic process GO:0016127 11 9 0,000 0,04078467 0,07831439 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04078467 0,07825193 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,04078467 0,07818958 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,04078467 0,07812733 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,04078467 0,07806517 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,04078467 0,07800312 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,04078467 0,07794116 ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,04078467 0,07787931 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,04078467 0,07781755 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04078467 0,07775588 ! purine base metabolic process GO:0006144 21 9 0,000 0,04078467 0,07769432 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,04078467 0,07763285 ! pigment granule transport GO:0051904 17 9 0,000 0,04078467 0,07757148 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,04078467 0,07751021 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,04078467 0,07744903 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04078467 0,07738795 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04078467 0,07732697 ! mitochondrion localization GO:0051646 15 9 0,000 0,04078467 0,07726608 ! appendage morphogenesis GO:0035107 135 70 1,000 0,04164742 0,07883847 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 136 71 1,000 0,04272784 0,08082012 GO:0060173|limb development, ! B cell activation GO:0042113 160 71 1,000 0,04272784 0,08075663 ! regulation of immune effector process GO:0002697 137 71 1,000 0,04272784 0,08069324 ! lipoprotein metabolic process GO:0042157 131 73 1,000 0,04491988 0,08476646 ! axon guidance GO:0007411 139 73 1,000 0,04491988 0,08470003 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0452131 0,08518615 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,0452131 0,08511949 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0452131 0,08505294 ! synapsis GO:0007129 13 10 0,000 0,0452131 0,08498649 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,0452131 0,08492015 ! N-glycan processing GO:0006491 20 10 0,000 0,0452131 0,08485391 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,0452131 0,08478777 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,0452131 0,08472174 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,0452131 0,0846558 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,0452131 0,08458998 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,0452131 0,08452425 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,0452131 0,08445862 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,0452131 0,0843931 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,0452131 0,08432768 ! androgen metabolic process GO:0008209 17 10 0,000 0,0452131 0,08426236 ! phospholipid efflux GO:0033700 16 10 0,000 0,0452131 0,08419714 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0452131 0,08413202 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,0452131 0,08406701 ! pathogenesis GO:0009405 13 10 0,000 0,0452131 0,08400209 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0452131 0,08393727 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,0452131 0,08387256 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,0452131 0,08380794 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,0452131 0,08374342 ! endoderm development GO:0007492 16 10 0,000 0,0452131 0,08367901 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,0452131 0,08361469 ! arginine catabolic process GO:0006527 13 10 0,000 0,0452131 0,08355047 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0452131 0,08348635 ! proline metabolic process GO:0006560 13 10 0,000 0,0452131 0,08342232 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0452131 0,0833584 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,0452131 0,08329457 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,0452131 0,08323084 ! V(D)J recombination GO:0033151 28 10 0,000 0,0452131 0,08316721 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0452131 0,08310367 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,0452131 0,08304024 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,0452131 0,08297689 ! B cell proliferation GO:0042100 18 10 0,000 0,0452131 0,08291365 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,0452131 0,0828505 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,0452131 0,08278745 ! multicellular organism growth GO:0035264 18 10 0,000 0,0452131 0,08272449 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,0452131 0,08266163 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,0452131 0,08259887 ! epithelial cell development GO:0002064 20 10 0,000 0,0452131 0,0825362 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,0452131 0,08247362 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0452131 0,08241114 ! macroautophagy GO:0016236 17 10 0,000 0,0452131 0,08234876 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,0452131 0,08228647 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,0452131 0,08222427 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,0452131 0,08216217 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,0452131 0,08210016 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0452131 0,08203824 ! brain morphogenesis GO:0048854 23 10 0,000 0,0452131 0,08197642 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,0452131 0,08191469 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,0452131 0,08185305 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,0452131 0,08179151 ! blastoderm segmentation GO:0007350 18 10 0,000 0,0452131 0,08173006 ! response to dsRNA GO:0043331 20 10 0,000 0,0452131 0,0816687 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0452131 0,08160743 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0452131 0,08154626 ! melanosome localization GO:0032400 16 10 0,000 0,0452131 0,08148517 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,0452131 0,08142418 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,0452131 0,08136328 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,0452131 0,08130247 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0452131 0,08124175 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,0452131 0,08118113 ! mRNA cleavage GO:0006379 17 10 0,000 0,0452131 0,08112059 ! protein sumoylation GO:0016925 15 10 0,000 0,0452131 0,08106014 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0452131 0,08099978 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0452131 0,08093952 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0452131 0,08087934 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,0452131 0,08081925 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,0452131 0,08075925 ! salivary gland development GO:0007431 27 10 0,000 0,0452131 0,08069934 ! prophase GO:0051324 15 10 0,000 0,0452131 0,08063952 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0452131 0,08057978 ! apical protein localization GO:0045176 15 10 0,000 0,0452131 0,08052014 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,0452131 0,08046058 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,0452131 0,08040111 ! midbrain development GO:0030901 13 10 0,000 0,0452131 0,08034173 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0452131 0,08028244 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,0452131 0,08022324 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,0452131 0,08016412 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,0452131 0,08010509 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0452131 0,08004614 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0452131 0,07998729 ! detection of calcium ion GO:0005513 23 10 0,000 0,0452131 0,07992851 ! oocyte development GO:0048599 17 10 0,000 0,0452131 0,07986983 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0452131 0,07981123 ! blastocyst formation GO:0001825 17 10 0,000 0,0452131 0,07975272 ! cerebellar cortex development GO:0021695 15 10 0,000 0,0452131 0,07969429 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,0452131 0,07963595 ! activation of innate immune response GO:0002218 12 10 0,000 0,0452131 0,07957769 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,0452131 0,07951952 ! response to nicotine GO:0035094 20 10 0,000 0,0452131 0,07946144 ! establishment of cell polarity GO:0030010 16 10 0,000 0,0452131 0,07940344 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,0452131 0,07934552 ! neurotransmitter transport GO:0006836 123 74 1,000 0,04603127 0,08072247 ! exocytosis GO:0006887 133 74 1,000 0,04603127 0,08066368 ! leukocyte mediated immunity GO:0002443 128 74 1,000 0,04603127 0,08060497 ! organelle localization GO:0051640 136 74 1,000 0,04603127 0,08054635 ! meiosis GO:0007126 121 74 1,000 0,04603127 0,08048781 GO:0051327|M phase of meiotic cell cycle, ! eye development GO:0001654 143 74 1,000 0,04603127 0,08042936 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,04715274 0,08232909 ! meiotic cell cycle GO:0051321 122 75 1,000 0,04715274 0,08226939 ! development of primary sexual characteristics GO:0045137 124 76 1,000 0,04828418 0,08418241 ! positive regulation of lymphocyte activation GO:0051251 127 77 1,000 0,04942548 0,08610985 ! respiratory burst GO:0045730 17 11 0,000 0,04962122 0,08638832 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,04962122 0,08632585 ! neuron fate specification GO:0048665 17 11 0,000 0,04962122 0,08626348 ! telencephalon cell migration GO:0022029 20 11 0,000 0,04962122 0,08620119 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,04962122 0,086139 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,04962122 0,0860769 ! thyroid gland development GO:0030878 26 11 0,000 0,04962122 0,08601488 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,04962122 0,08595295 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,04962122 0,08589112 ! response to pain GO:0048265 24 11 0,000 0,04962122 0,08582937 ! T cell proliferation GO:0042098 26 11 0,000 0,04962122 0,08576771 ! bone resorption GO:0045453 16 11 0,000 0,04962122 0,08570614 ! ventral spinal cord development GO:0021517 21 11 0,000 0,04962122 0,08564466 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04962122 0,08558326 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04962122 0,08552196 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,04962122 0,08546074 ! melanocyte differentiation GO:0030318 21 11 0,000 0,04962122 0,08539961 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,04962122 0,08533857 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,04962122 0,08527761 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,04962122 0,08521674 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,04962122 0,08515596 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,04962122 0,08509526 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,04962122 0,08503465 ! UV protection GO:0009650 19 11 0,000 0,04962122 0,08497413 ! adult heart development GO:0007512 14 11 0,000 0,04962122 0,08491369 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04962122 0,08485334 ! temperature homeostasis GO:0001659 17 11 0,000 0,04962122 0,08479308 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,04962122 0,0847329 ! negative regulation of ossification GO:0030279 26 11 0,000 0,04962122 0,0846728 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,04962122 0,0846128 ! regulation of organ growth GO:0046620 13 11 0,000 0,04962122 0,08455287 ! pigment granule localization GO:0051875 20 11 0,000 0,04962122 0,08449303 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,04962122 0,08443328 ! vasoconstriction GO:0042310 18 11 0,000 0,04962122 0,08437361 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04962122 0,08431402 ! embryonic axis specification GO:0000578 18 11 0,000 0,04962122 0,08425452 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,04962122 0,0841951 ! snRNA metabolic process GO:0016073 24 11 0,000 0,04962122 0,08413577 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04962122 0,08407652 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,04962122 0,08401735 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,04962122 0,08395827 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,04962122 0,08389926 ! zymogen activation GO:0031638 15 11 0,000 0,04962122 0,08384035 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,04962122 0,08378151 ! nucleosome positioning GO:0016584 15 11 0,000 0,04962122 0,08372276 ! regulation of isotype switching GO:0045191 22 11 0,000 0,04962122 0,08366409 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,04962122 0,0836055 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,04962122 0,08354699 ! acid secretion GO:0046717 18 11 0,000 0,04962122 0,08348857 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04962122 0,08343023 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,04962122 0,08337196 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,04962122 0,08331378 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,04962122 0,08325569 ! oocyte differentiation GO:0009994 18 11 0,000 0,04962122 0,08319767 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,04962122 0,08313973 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,04962122 0,08308187 ! cholesterol efflux GO:0033344 19 11 0,000 0,04962122 0,0830241 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,04962122 0,0829664 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04962122 0,08290879 ! germ cell migration GO:0008354 25 11 0,000 0,04962122 0,08285125 ! embryonic gut development GO:0048566 15 11 0,000 0,04962122 0,0827938 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,04962122 0,08273642 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,04962122 0,08267912 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,04962122 0,08262191 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,04962122 0,08256477 ! defense response to fungus GO:0050832 13 11 0,000 0,04962122 0,08250771 ! developmental induction GO:0031128 19 11 0,000 0,04962122 0,08245073 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,04962122 0,08239383 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04962122 0,082337 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,04962122 0,08228026 ! sequestering of metal ion GO:0051238 14 11 0,000 0,04962122 0,08222359 ! lamellipodium assembly GO:0030032 20 11 0,000 0,04962122 0,082167 ! nucleus localization GO:0051647 19 11 0,000 0,04962122 0,08211049 ! regulation of synapse organization GO:0050807 17 11 0,000 0,04962122 0,08205406 ! negative regulation of organelle organization GO:0010639 161 78 1,000 0,05057652 0,08357631 ! activation of protein kinase activity GO:0032147 147 79 1,000 0,05173719 0,08543561 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,05173719 0,08537701 ! protein import into nucleus GO:0006606 158 80 1,000 0,05290738 0,08724823 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,05400914 0,0890041 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,05400914 0,08894318 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,05400914 0,08888234 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,05400914 0,08882159 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,05400914 0,08876092 ! mating GO:0007618 17 12 0,000 0,05400914 0,08870033 ! protein complex disassembly GO:0043241 27 12 0,000 0,05400914 0,08863983 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05400914 0,0885794 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,05400914 0,08851906 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,05400914 0,0884588 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,05400914 0,08839863 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05400914 0,08833853 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,05400914 0,08827852 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,05400914 0,08821859 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,05400914 0,08815874 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,05400914 0,08809897 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,05400914 0,08803928 ! drug transport GO:0015893 16 12 0,000 0,05400914 0,08797968 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,05400914 0,08792015 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,05400914 0,08786071 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,05400914 0,08780134 ! polyamine metabolic process GO:0006595 17 12 0,000 0,05400914 0,08774206 ! focal adhesion formation GO:0048041 35 12 0,000 0,05400914 0,08768285 ! mitotic spindle organization GO:0007052 21 12 0,000 0,05400914 0,08762372 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,05400914 0,08756468 ! forebrain cell migration GO:0021885 21 12 0,000 0,05400914 0,08750571 ! asymmetric protein localization GO:0008105 20 12 0,000 0,05400914 0,08744683 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,05400914 0,08738802 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,05400914 0,08732929 ! entry into host cell GO:0030260 32 12 0,000 0,05400914 0,08727064 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 26 12 0,000 0,05400914 0,08721207 ! monoamine transport GO:0015844 18 12 0,000 0,05400914 0,08715358 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05400914 0,08709516 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,05400914 0,08703683 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,05400914 0,08697857 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,05400914 0,08692039 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05400914 0,08686229 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,05400914 0,08680426 ! protein homotetramerization GO:0051289 21 12 0,000 0,05400914 0,08674632 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,05400914 0,08668845 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,05400914 0,08663066 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05400914 0,08657294 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,05400914 0,0865153 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,05400914 0,08645774 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05400914 0,08640026 ! cranial nerve development GO:0021545 20 12 0,000 0,05400914 0,08634285 ! fucose catabolic process GO:0019317 22 12 0,000 0,05400914 0,08628551 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,05400914 0,08622826 ! histone methylation GO:0016571 26 12 0,000 0,05400914 0,08617108 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,05400914 0,08611397 ! gland morphogenesis GO:0022612 29 12 0,000 0,05400914 0,08605694 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,05400914 0,08599999 ! T cell homeostasis GO:0043029 25 12 0,000 0,05400914 0,08594311 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,05400914 0,08588631 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,05400914 0,08582958 ! spleen development GO:0048536 22 12 0,000 0,05400914 0,08577293 ! digestive tract morphogenesis GO:0048546 26 12 0,000 0,05400914 0,08571635 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,05400914 0,08565984 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,05400914 0,08560341 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,05400914 0,08554706 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,05400914 0,08549078 ! response to cold GO:0009409 17 12 0,000 0,05400914 0,08543457 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,05400914 0,08537844 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,05400914 0,08532238 ! digestion GO:0007586 112 81 1,000 0,05408698 0,08538929 ! cell-substrate adhesion GO:0031589 171 81 1,000 0,05408698 0,0853333 ! nuclear import GO:0051170 161 81 1,000 0,05408698 0,08527738 ! regulation of neuron differentiation GO:0045664 167 81 1,000 0,05408698 0,08522154 ! response to nutrient GO:0007584 125 82 1,000 0,05527588 0,08703781 ! regulation of ligase activity GO:0051340 142 84 1,000 0,05768113 0,09076573 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05837694 0,0918006 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,05837694 0,09174064 ! regulation of chemokine production GO:0032642 18 13 0,000 0,05837694 0,09168076 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05837694 0,09162095 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,05837694 0,09156123 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,05837694 0,09150158 ! lipid localization GO:0010876 28 13 0,000 0,05837694 0,091442 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,05837694 0,09138251 ! organelle fusion GO:0048284 32 13 0,000 0,05837694 0,09132309 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,05837694 0,09126376 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,05837694 0,09120449 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,05837694 0,09114531 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,05837694 0,0910862 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,05837694 0,09102717 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,05837694 0,09096821 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,05837694 0,09090933 ! methionine metabolic process GO:0006555 27 13 0,000 0,05837694 0,09085053 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,05837694 0,0907918 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,05837694 0,09073315 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,05837694 0,09067458 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,05837694 0,09061608 ! cytokine metabolic process GO:0042107 22 13 0,000 0,05837694 0,09055765 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,05837694 0,0904993 ! exocrine system development GO:0035272 32 13 0,000 0,05837694 0,09044103 ! negative regulation of mitotic cell cycle GO:0045930 33 13 0,000 0,05837694 0,09038283 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,05837694 0,09032471 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,05837694 0,09026666 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,05837694 0,09020868 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,05837694 0,09015078 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,05837694 0,09009296 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,05837694 0,0900352 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,05837694 0,08997753 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,05837694 0,08991992 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05837694 0,08986239 ! ribosome assembly GO:0042255 17 13 0,000 0,05837694 0,08980494 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,05837694 0,08974755 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,05837694 0,08969024 ! chromatin silencing GO:0006342 26 13 0,000 0,05837694 0,08963301 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,05837694 0,08957584 ! regulation of epidermis development GO:0045682 19 13 0,000 0,05837694 0,08951875 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05837694 0,08946173 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,05837694 0,08940479 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,05837694 0,08934791 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05837694 0,08929111 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,05837694 0,08923438 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,05837694 0,08917773 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,05837694 0,08912114 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,05837694 0,08906463 ! embryonic placenta development GO:0001892 23 13 0,000 0,05837694 0,08900819 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,05837694 0,08895182 ! insulin secretion GO:0030073 23 13 0,000 0,05837694 0,08889552 ! actin filament polymerization GO:0030041 24 13 0,000 0,05837694 0,08883929 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,05837694 0,08878313 ! acrosome reaction GO:0007340 18 13 0,000 0,05837694 0,08872705 ! positive regulation of cell activation GO:0050867 145 85 1,000 0,05889727 0,08946138 GO:0002696|positive regulation of leukocyte activation, ! protein localization in nucleus GO:0034504 176 87 1,000 0,06135602 0,09313728 ! rRNA transcription GO:0009303 25 14 0,000 0,06272472 0,09515491 ! lactation GO:0007595 26 14 0,000 0,06272472 0,09509495 ! reproductive cellular process GO:0048610 20 14 0,000 0,06272472 0,09503506 ! tRNA modification GO:0006400 20 14 0,000 0,06272472 0,09497526 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,06272472 0,09491552 ! regulation of S phase GO:0033261 23 14 0,000 0,06272472 0,09485586 ! water transport GO:0006833 21 14 0,000 0,06272472 0,09479628 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,06272472 0,09473677 ! non-recombinational repair GO:0000726 25 14 0,000 0,06272472 0,09467734 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,06272472 0,09461798 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,06272472 0,0945587 ! hair follicle morphogenesis GO:0031069 26 14 0,000 0,06272472 0,09449949 ! RNA polyadenylation GO:0043631 30 14 0,000 0,06272472 0,09444035 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,06272472 0,09438129 ! palate development GO:0060021 31 14 0,000 0,06272472 0,0943223 ! regulated secretory pathway GO:0045055 23 14 0,000 0,06272472 0,09426339 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,06272472 0,09420454 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,06272472 0,09414578 ! arginine metabolic process GO:0006525 17 14 0,000 0,06272472 0,09408708 ! regulation of heart rate GO:0002027 24 14 0,000 0,06272472 0,09402846 ! organic alcohol transport GO:0015850 29 14 0,000 0,06272472 0,09396991 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,06272472 0,09391144 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,06272472 0,09385304 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 0,000 0,06272472 0,09379471 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,06272472 0,09373645 ! neutral amino acid transport GO:0015804 26 14 0,000 0,06272472 0,09367826 ! L-amino acid transport GO:0015807 30 14 0,000 0,06272472 0,09362015 ! bone mineralization GO:0030282 17 14 0,000 0,06272472 0,09356211 ! stem cell development GO:0048864 43 14 0,000 0,06272472 0,09350414 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,06272472 0,09344624 ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,06272472 0,09338842 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06272472 0,09333066 ! cerebellum development GO:0021549 21 14 0,000 0,06272472 0,09327298 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,06272472 0,09321537 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,06272472 0,09315783 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,06272472 0,09310036 ! cofactor transport GO:0051181 26 14 0,000 0,06272472 0,09304296 ! NADP metabolic process GO:0006739 24 14 0,000 0,06272472 0,09298563 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,06272472 0,09292838 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,06272472 0,09287119 ! intestinal absorption GO:0050892 25 14 0,000 0,06272472 0,09281407 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,06272472 0,09275703 ! oxygen transport GO:0015671 21 14 0,000 0,06272472 0,09270005 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,06272472 0,09264314 ! male genitalia development GO:0030539 24 14 0,000 0,06272472 0,09258631 ! regulation of axon extension GO:0030516 37 14 0,000 0,06272472 0,09252954 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,06272472 0,09247284 ! regulation of cell morphogenesis GO:0022604 215 89 1,000 0,06384939 0,09407325 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,06705257 0,09873224 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06705257 0,09867186 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,06705257 0,09861155 ! superoxide anion generation GO:0042554 20 15 0,000 0,06705257 0,09855131 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,06705257 0,09849114 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,06705257 0,09843105 ! copper ion transport GO:0006825 20 15 0,000 0,06705257 0,09837103 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,06705257 0,09831108 ! sulfate transport GO:0008272 23 15 0,000 0,06705257 0,09825121 ! response to cAMP GO:0051591 22 15 0,000 0,06705257 0,09819141 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,06705257 0,09813168 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,06705257 0,09807203 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,06705257 0,09801245 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,06705257 0,09795294 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,06705257 0,0978935 ! response to hexose stimulus GO:0009746 22 15 0,000 0,06705257 0,09783413 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,06705257 0,09777484 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,06705257 0,09771562 ! pituitary gland development GO:0021983 29 15 0,000 0,06705257 0,09765647 ! vesicle coating GO:0006901 33 15 0,000 0,06705257 0,09759739 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,06705257 0,09753838 ! regulation of exocytosis GO:0017157 22 15 0,000 0,06705257 0,09747945 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,06705257 0,09742058 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,06705257 0,09736179 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,06705257 0,09730307 ! regulation of vasodilation GO:0042312 26 15 0,000 0,06705257 0,09724442 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,06705257 0,09718584 ! histone deacetylation GO:0016575 20 15 0,000 0,06705257 0,09712733 ! mRNA splice site selection GO:0006376 38 15 0,000 0,06705257 0,09706889 ! tissue regeneration GO:0042246 26 15 0,000 0,06705257 0,09701052 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,06705257 0,09695222 ! water homeostasis GO:0030104 27 15 0,000 0,06705257 0,09689399 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06705257 0,09683583 ! muscle maintenance GO:0046716 26 15 0,000 0,06705257 0,09677774 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,06705257 0,09671972 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,06705257 0,09666177 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,06705257 0,09660388 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06705257 0,09654607 ! heme biosynthetic process GO:0006783 29 15 0,000 0,06705257 0,09648833 ! lymphocyte homeostasis GO:0002260 30 15 0,000 0,06705257 0,09643066 ! detection of bacterium GO:0016045 18 15 0,000 0,06705257 0,09637305 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,06705257 0,09631552 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,06705257 0,09625805 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,06705257 0,09620065 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,06705257 0,09614332 ! peptide hormone processing GO:0016486 23 15 0,000 0,06705257 0,09608606 ! phospholipid biosynthetic process GO:0008654 167 92 1,000 0,0676525 0,09688805 ! vitamin metabolic process GO:0006766 139 92 1,000 0,0676525 0,09683041 ! carbohydrate biosynthetic process GO:0016051 141 93 1,000 0,06893661 0,09860969 ! transcription initiation GO:0006352 153 94 1,000 0,07022876 0,10039834 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,07136058 0,10195579 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,07136058 0,10189529 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,07136058 0,10183485 ! bone remodeling GO:0046849 27 16 0,000 0,07136058 0,10177449 ! filopodium assembly GO:0046847 32 16 0,000 0,07136058 0,10171419 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 0,000 0,07136058 0,10165397 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,07136058 0,10159382 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,07136058 0,10153374 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,07136058 0,10147373 ! startle response GO:0001964 28 16 0,000 0,07136058 0,1014138 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,07136058 0,10135393 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,07136058 0,10129413 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,07136058 0,10123441 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,07136058 0,10117475 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,07136058 0,10111517 ! protein polyubiquitination GO:0000209 34 16 0,000 0,07136058 0,10105565 ! glutamate metabolic process GO:0006536 22 16 0,000 0,07136058 0,10099621 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,07136058 0,10093684 ! response to osmotic stress GO:0006970 25 16 0,000 0,07136058 0,10087753 ! negative regulation of microtubule depolymerization GO:0007026 46 16 0,000 0,07136058 0,1008183 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 26 16 0,000 0,07136058 0,10075913 ! fructose metabolic process GO:0006000 25 16 0,000 0,07136058 0,10070003 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07136058 0,10064101 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,07136058 0,10058205 ! intermediate filament-based process GO:0045103 32 16 0,000 0,07136058 0,10052316 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,07136058 0,10046434 ! negative regulation of immune response GO:0050777 35 16 0,000 0,07136058 0,10040559 ! axon cargo transport GO:0008088 43 16 0,000 0,07136058 0,10034691 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,07136058 0,10028829 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,07136058 0,10022975 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,07136058 0,10017127 ! DNA replication initiation GO:0006270 27 16 0,000 0,07136058 0,10011286 ! neuron recognition GO:0008038 35 16 0,000 0,07136058 0,10005452 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,07136058 0,09999625 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,07136058 0,09993804 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,07136058 0,09987991 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,07136058 0,09982184 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,07136058 0,09976383 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,07136058 0,0997059 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,07136058 0,09964803 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07136058 0,09959023 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,07136058 0,0995325 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,07136058 0,09947483 ! defense response to virus GO:0051607 37 16 0,000 0,07136058 0,09941723 ! regulation of Rho protein signal transduction GO:0035023 213 95 1,000 0,07152884 0,09959398 ! detection of stimulus GO:0051606 151 96 1,000 0,07283676 0,10135641 ! hormone metabolic process GO:0042445 157 97 1,000 0,07415241 0,10312757 ! response to virus GO:0009615 160 98 1,000 0,0754757 0,1049073 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,07564884 0,10508725 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,07564884 0,10502661 ! metencephalon development GO:0022037 30 17 0,000 0,07564884 0,10496604 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,07564884 0,10490554 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,07564884 0,10484511 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,07564884 0,10478475 ! signal complex assembly GO:0007172 41 17 0,000 0,07564884 0,10472446 ! endothelial cell migration GO:0043542 28 17 0,000 0,07564884 0,10466424 ! inositol metabolic process GO:0006020 28 17 0,000 0,07564884 0,10460409 ! gene silencing by RNA GO:0031047 36 17 0,000 0,07564884 0,104544 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,07564884 0,10448399 ! glial cell development GO:0021782 27 17 0,000 0,07564884 0,10442404 ! adult walking behavior GO:0007628 33 17 0,000 0,07564884 0,10436417 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,07564884 0,10430436 ! heart looping GO:0001947 30 17 0,000 0,07564884 0,10424462 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,07564884 0,10418495 ! myoblast differentiation GO:0045445 45 17 0,000 0,07564884 0,10412535 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,07564884 0,10406581 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,07564884 0,10400635 ! glycine metabolic process GO:0006544 28 17 0,000 0,07564884 0,10394695 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,07564884 0,10388762 ! NAD metabolic process GO:0019674 29 17 0,000 0,07564884 0,10382836 ! membrane budding GO:0006900 37 17 0,000 0,07564884 0,10376916 ! DNA integration GO:0015074 29 17 0,000 0,07564884 0,10371003 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,07564884 0,10365097 ! regulation of protein binding GO:0043393 33 17 0,000 0,07564884 0,10359198 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,07564884 0,10353305 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,07564884 0,10347419 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,07564884 0,1034154 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,07564884 0,10335668 GO:0002712|regulation of B cell mediated immunity, ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,07564884 0,10329802 ! steroid catabolic process GO:0006706 31 17 0,000 0,07564884 0,10323943 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,07564884 0,1031809 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,07564884 0,10312244 ! gas transport GO:0015669 25 17 0,000 0,07564884 0,10306405 ! organic cation transport GO:0015695 31 17 0,000 0,07564884 0,10300572 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,07564884 0,10294746 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,07564884 0,10288926 ! microspike assembly GO:0030035 36 17 0,000 0,07564884 0,10283113 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,07564884 0,10277307 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 0,000 0,07564884 0,10271507 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,07991744 0,10844972 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,07991744 0,10838859 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,07991744 0,10832752 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,07991744 0,10826653 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,07991744 0,1082056 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,07991744 0,10814474 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,07991744 0,10808396 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,07991744 0,10802323 ! patterning of blood vessels GO:0001569 39 18 0,000 0,07991744 0,10796258 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,07991744 0,107902 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,07991744 0,10784148 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,07991744 0,10778103 ! epidermis morphogenesis GO:0048730 40 18 0,000 0,07991744 0,10772065 ! glutamine metabolic process GO:0006541 29 18 0,000 0,07991744 0,10766033 ! response to fungus GO:0009620 21 18 0,000 0,07991744 0,10760009 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,07991744 0,10753991 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,07991744 0,1074798 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,07991744 0,10741975 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,07991744 0,10735977 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,07991744 0,10729986 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,07991744 0,10724002 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,07991744 0,10718024 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,07991744 0,10712053 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,07991744 0,10706089 ! nerve development GO:0021675 28 18 0,000 0,07991744 0,10700131 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,07991744 0,1069418 ! protein secretion GO:0009306 39 19 0,000 0,08416647 0,11256505 ! positive regulation of translation GO:0045727 30 19 0,000 0,08416647 0,11250251 ! negative regulation of defense response GO:0031348 25 19 0,000 0,08416647 0,11244004 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,08416647 0,11237764 ! skin development GO:0043588 36 19 0,000 0,08416647 0,11231532 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,08416647 0,11225306 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,08416647 0,11219087 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,08416647 0,11212875 ! bile acid metabolic process GO:0008206 29 19 0,000 0,08416647 0,11206669 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,08416647 0,11200471 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,08416647 0,1119428 ! cerebral cortex development GO:0021987 36 19 0,000 0,08416647 0,11188095 ! pigmentation during development GO:0048066 41 19 0,000 0,08416647 0,11181917 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,08416647 0,11175746 GO:0030968|endoplasmic reticulum unfolded protein response, ! heme metabolic process GO:0042168 36 19 0,000 0,08416647 0,11169582 ! actin filament bundle formation GO:0051017 42 19 0,000 0,08416647 0,11163424 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,08416647 0,11157274 ! peptide cross-linking GO:0018149 37 19 0,000 0,08416647 0,1115113 ! protein export from nucleus GO:0006611 36 19 0,000 0,08416647 0,11144993 ! heart process GO:0003015 30 19 0,000 0,08416647 0,11138862 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,08416647 0,11132739 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,08416647 0,11126622 ! visual learning GO:0008542 36 19 0,000 0,08416647 0,11120512 ! cellular pigmentation GO:0033059 36 19 0,000 0,08416647 0,11114408 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,08416647 0,11108311 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,08416647 0,11102221 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,08416647 0,11096138 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,08416647 0,11090061 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,08416647 0,11083991 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,08416647 0,11077928 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,08416647 0,11071871 ! cilium assembly GO:0042384 37 19 0,000 0,08416647 0,11065821 ! peptide hormone secretion GO:0030072 31 19 0,000 0,08416647 0,11059777 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,08839601 0,11609214 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,08839601 0,11602881 ! positive regulation of ossification GO:0045778 47 20 0,000 0,08839601 0,11596554 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,08839601 0,11590234 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,08839601 0,11583922 ! cAMP metabolic process GO:0046058 36 20 0,000 0,08839601 0,11577616 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,08839601 0,11571317 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,08839601 0,11565025 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,08839601 0,11558739 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,08839601 0,11552461 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,08839601 0,11546189 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,08839601 0,11539924 GO:0032392|DNA geometric change, ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,08839601 0,11533666 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,08839601 0,11527415 ! body fluid secretion GO:0007589 31 20 0,000 0,08839601 0,1152117 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,08839601 0,11514932 ! peptide secretion GO:0002790 35 20 0,000 0,08839601 0,11508701 ! stem cell differentiation GO:0048863 53 20 0,000 0,08839601 0,11502477 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,08839601 0,1149626 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,08839601 0,11490049 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,08839601 0,11483845 ! sensory perception of pain GO:0019233 30 20 0,000 0,08839601 0,11477647 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,08839601 0,11471456 ! diencephalon development GO:0021536 34 20 0,000 0,08839601 0,11465272 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,08839601 0,11459095 GO:0006626|protein targeting to mitochondrion, ! detection of chemical stimulus GO:0009593 37 20 0,000 0,08839601 0,11452924 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,08839601 0,1144676 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,08839601 0,11440603 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,08839601 0,11434452 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,08839601 0,11428308 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,08839601 0,1142217 ! actin filament-based movement GO:0030048 43 20 0,000 0,08839601 0,11416039 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,08839601 0,11409914 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,08839601 0,11403796 ! negative regulation of translation GO:0017148 29 20 0,000 0,08839601 0,11397685 ! regulation of cell killing GO:0031341 42 21 0,000 0,09260616 0,11934142 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,09260616 0,11927753 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,09260616 0,11921371 ! hormone secretion GO:0046879 38 21 0,000 0,09260616 0,11914996 ! glycerol metabolic process GO:0006071 34 21 0,000 0,09260616 0,11908628 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,09260616 0,11902267 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,09260616 0,11895912 ! axis specification GO:0009798 38 21 0,000 0,09260616 0,11889564 ! ovarian follicle development GO:0001541 35 21 0,000 0,09260616 0,11883223 ! smooth muscle contraction GO:0006939 46 21 0,000 0,09260616 0,11876889 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,09260616 0,11870561 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,09260616 0,1186424 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,09260616 0,11857926 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,09260616 0,11851619 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,09260616 0,11845318 ! cytolysis GO:0019835 24 21 0,000 0,09260616 0,11839024 ! vasodilation GO:0042311 39 21 0,000 0,09260616 0,11832737 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,09260616 0,11826456 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,09260616 0,11820182 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,09260616 0,11813915 ! oogenesis GO:0048477 36 21 0,000 0,09260616 0,11807654 ! DNA modification GO:0006304 34 21 0,000 0,09260616 0,118014 ! collagen fibril organization GO:0030199 59 21 0,000 0,09260616 0,11795152 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,09260616 0,11788912 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,09260616 0,11782677 ! negative regulation of intracellular transport GO:0032387 41 21 0,000 0,09260616 0,1177645 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,09260616 0,11770229 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,09260616 0,11764014 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,09260616 0,11757806 ! collagen catabolic process GO:0030574 28 21 0,000 0,09260616 0,11751605 ! sperm-egg recognition GO:0035036 21 21 0,000 0,09260616 0,1174541 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,09679701 0,12270475 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,09679701 0,12264013 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,09679701 0,12257558 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,09679701 0,1225111 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,09679701 0,12244669 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,09679701 0,12238235 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,09679701 0,12231807 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,09679701 0,12225386 ! regeneration GO:0031099 41 22 0,000 0,09679701 0,12218972 ! keratinization GO:0031424 28 22 0,000 0,09679701 0,12212565 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,09679701 0,12206164 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,09679701 0,1219977 ! sensory perception of taste GO:0050909 28 22 0,000 0,09679701 0,12193383 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,09679701 0,12187002 ! vacuolar transport GO:0007034 36 22 0,000 0,09679701 0,12180628 ! lysosome organization GO:0007040 41 22 0,000 0,09679701 0,12174261 ! central nervous system neuron development GO:0021954 46 22 0,000 0,09679701 0,121679 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,09679701 0,12161546 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,09679701 0,12155199 ! fucose metabolic process GO:0006004 39 22 0,000 0,09679701 0,12148858 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,09679701 0,12142524 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,09679701 0,12136196 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,09679701 0,12129875 ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,09679701 0,12123561 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,09679701 0,12117253 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,09679701 0,12110952 ! sarcomere organization GO:0045214 30 22 0,000 0,09679701 0,12104657 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,09679701 0,12098369 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,09679701 0,12092088 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,09679701 0,12085813 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 0,000 0,09679701 0,12079544 ! protein stabilization GO:0050821 39 22 0,000 0,09679701 0,12073282 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,10096864 0,12587075 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,10096864 0,12580557 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,10096864 0,12574045 ! viral genome replication GO:0019079 41 23 0,000 0,10096864 0,1256754 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,10096864 0,12561042 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,10096864 0,1255455 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,10096864 0,12548066 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,10096864 0,12541588 GO:0006044|N-acetylglucosamine metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,10096864 0,12535116 ! visual behavior GO:0007632 42 23 0,000 0,10096864 0,12528651 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,10096864 0,12522193 ! response to ethanol GO:0045471 46 23 0,000 0,10096864 0,12515742 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,10096864 0,12509297 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,10096864 0,12502859 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,10096864 0,12496428 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,10096864 0,12490003 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,10096864 0,12483584 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,10096864 0,12477173 GO:0051693|actin filament capping, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,10096864 0,12470767 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,10096864 0,12464369 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,10096864 0,12457977 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,10096864 0,12451592 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,10096864 0,12445213 ! fatty acid transport GO:0015908 44 23 0,000 0,10096864 0,1243884 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,10096864 0,12432474 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,10096864 0,12426115 ! hormone transport GO:0009914 40 23 0,000 0,10096864 0,12419762 ! cell-cell recognition GO:0009988 25 23 0,000 0,10096864 0,12413416 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,10096864 0,12407076 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,10096864 0,12400743 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,10096864 0,12394416 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,10096864 0,12388095 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,10096864 0,12381781 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,10512114 0,12884435 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,10512114 0,12877875 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,10512114 0,12871322 ! vesicle docking GO:0048278 47 24 0,000 0,10512114 0,12864775 ! spinal cord development GO:0021510 47 24 0,000 0,10512114 0,12858234 ! vacuole organization GO:0007033 43 24 0,000 0,10512114 0,12851701 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,10512114 0,12845174 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,10512114 0,12838653 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,10512114 0,12832139 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,10512114 0,12825632 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,10512114 0,12819132 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,10512114 0,12812638 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,10512114 0,1280615 ! membrane depolarization GO:0051899 39 24 0,000 0,10512114 0,12799669 ! pentose metabolic process GO:0019321 35 24 0,000 0,10512114 0,12793195 ! leukocyte homeostasis GO:0001776 44 24 0,000 0,10512114 0,12786727 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,10512114 0,12780266 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,10512114 0,12773811 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,10512114 0,12767363 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,10512114 0,12760922 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,10512114 0,12754487 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,10512114 0,12748058 ! regulation of amine transport GO:0051952 40 24 0,000 0,10512114 0,12741636 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,1092546 0,1323598 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,1092546 0,13229319 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,1092546 0,13222664 ! phototransduction GO:0007602 33 25 0,000 0,1092546 0,13216017 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,1092546 0,13209375 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,1092546 0,13202741 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,1092546 0,13196113 ! receptor metabolic process GO:0043112 46 25 0,000 0,1092546 0,13189492 ! osteoblast differentiation GO:0001649 60 25 0,000 0,1092546 0,13182877 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,1092546 0,13176269 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,1092546 0,13169668 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,1092546 0,13163073 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,1092546 0,13156485 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,1092546 0,13149903 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,1092546 0,13143328 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,1092546 0,1313676 ! telomere organization GO:0032200 43 25 0,000 0,1092546 0,13130198 GO:0000723|telomere maintenance, ! liver development GO:0001889 53 25 0,000 0,1092546 0,13123643 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,1133691 0,13611081 ! embryonic pattern specification GO:0009880 44 26 0,000 0,1133691 0,13604292 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,1133691 0,13597511 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,1133691 0,13590736 ! initiation of viral infection GO:0019059 57 26 0,000 0,1133691 0,13583967 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,1133691 0,13577206 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,1133691 0,13570451 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,1133691 0,13563703 ! molting cycle process GO:0022404 50 26 0,000 0,1133691 0,13556961 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,1133691 0,13550227 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,1133691 0,13543499 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,1133691 0,13536777 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,1133691 0,13530063 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,1133691 0,13523355 ! cellular response to oxidative stress GO:0034599 39 26 0,000 0,1133691 0,13516653 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,1133691 0,13509958 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,1133691 0,1350327 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,1133691 0,13496589 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,1133691 0,13489914 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,1133691 0,13483246 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,1133691 0,13476584 ! blastocyst development GO:0001824 49 26 0,000 0,1133691 0,13469929 ! leukocyte proliferation GO:0070661 52 26 0,000 0,1133691 0,1346328 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,1133691 0,13456638 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,1133691 0,13450003 ! neuron fate commitment GO:0048663 48 27 0,000 0,11746474 0,13929037 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,11746474 0,13922175 ! iron ion transport GO:0006826 59 27 0,000 0,11746474 0,1391532 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,11746474 0,13908472 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,11746474 0,13901631 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,11746474 0,13894796 ! fat cell differentiation GO:0045444 50 27 0,000 0,11746474 0,13887968 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,11746474 0,13881147 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,11746474 0,13874333 ! autophagy GO:0006914 41 27 0,000 0,11746474 0,13867525 ! male gonad development GO:0008584 44 27 0,000 0,11746474 0,13860724 ! response to toxin GO:0009636 47 27 0,000 0,11746474 0,13853929 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,11746474 0,13847141 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,11746474 0,1384036 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,11746474 0,13833586 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,12154159 0,14306705 ! circadian rhythm GO:0007623 50 28 0,000 0,12154159 0,14299709 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,12154159 0,1429272 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 59 28 0,000 0,12154159 0,14285738 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,12154159 0,14278762 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,12154159 0,14271794 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,12154159 0,14264832 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,12154159 0,14257877 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,12154159 0,14250929 ! synaptogenesis GO:0007416 42 28 0,000 0,12154159 0,14243987 ! lipid oxidation GO:0034440 43 28 0,000 0,12154159 0,14237052 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,12154159 0,14230124 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,12154159 0,14223203 ! translational initiation GO:0006413 65 29 0,000 0,12559974 0,14690956 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,12559974 0,14683818 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,12559974 0,14676686 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,12559974 0,14669562 ! catechol metabolic process GO:0009712 54 29 0,000 0,12559974 0,14662444 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,12559974 0,14655333 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,12559974 0,14648229 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,12559974 0,14641132 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 55 29 0,000 0,12559974 0,14634042 ! cell fate determination GO:0001709 60 29 0,000 0,12559974 0,14626959 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,12559974 0,14619882 ! detection of light stimulus GO:0009583 38 29 0,000 0,12559974 0,14612813 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 0,000 0,12559974 0,1460575 ! negative regulation of neuron apoptosis GO:0043524 56 29 0,000 0,12559974 0,14598694 ! phenol metabolic process GO:0018958 55 30 0,000 0,12963928 0,15060941 ! zinc ion transport GO:0006829 45 30 0,000 0,12963928 0,15053673 ! membrane docking GO:0022406 61 30 0,000 0,12963928 0,15046411 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,12963928 0,15039156 ! regulation of innate immune response GO:0045088 51 30 0,000 0,12963928 0,15031908 ! acute-phase response GO:0006953 49 30 0,000 0,12963928 0,15024667 ! myofibril assembly GO:0030239 47 30 0,000 0,12963928 0,15017434 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,12963928 0,15010207 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,12963928 0,15002987 ! positive regulation of multicellular organism growth GO:0040018 51 30 0,000 0,12963928 0,14995774 ! phospholipid transport GO:0015914 51 30 0,000 0,12963928 0,14988568 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,12963928 0,14981369 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,12963928 0,14974177 ! response to heat GO:0009408 50 30 0,000 0,12963928 0,14966991 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,13366029 0,1542382 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,13366029 0,15416426 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,13366029 0,15409039 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,13366029 0,15401659 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,13366029 0,15394287 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,13366029 0,15386921 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,13366029 0,15379562 GO:0055092|sterol homeostasis, ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,13366029 0,15372211 ! ovulation cycle process GO:0022602 49 31 0,000 0,13366029 0,15364866 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,13366029 0,15357529 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,13366029 0,15350198 ! peptide transport GO:0015833 55 31 0,000 0,13366029 0,15342874 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,13366029 0,15335558 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,13366029 0,15328248 ! mesoderm formation GO:0001707 69 31 0,000 0,13366029 0,15320946 ! natural killer cell activation GO:0030101 45 31 0,000 0,13366029 0,1531365 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,13366029 0,15306361 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,13366029 0,15299079 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,13366029 0,15291804 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,13366029 0,15284536 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,13766285 0,15734766 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,13766285 0,15727295 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,13766285 0,1571983 ! cholesterol transport GO:0030301 56 32 0,000 0,13766285 0,15712373 ! spliceosome assembly GO:0000245 67 32 0,000 0,13766285 0,15704923 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,13766285 0,1569748 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,13766285 0,15690044 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,13766285 0,15682615 ! regulation of protein import into nucleus GO:0042306 63 32 0,000 0,13766285 0,15675193 ! muscle cell development GO:0055001 49 32 0,000 0,13766285 0,15667778 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,13766285 0,1566037 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,13766285 0,15652969 ! ovulation cycle GO:0042698 51 32 0,000 0,13766285 0,15645575 ! BMP signaling pathway GO:0030509 64 32 0,000 0,13766285 0,15638188 ! hindbrain development GO:0030902 61 32 0,000 0,13766285 0,15630808 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,13766285 0,15623435 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,13766285 0,15616069 ! gene silencing GO:0016458 65 32 0,000 0,13766285 0,1560871 ! post-embryonic development GO:0009791 69 33 0,000 0,14164706 0,16052889 ! protein targeting to membrane GO:0006612 68 33 0,000 0,14164706 0,16045331 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,14164706 0,1603778 ! ceramide metabolic process GO:0006672 64 33 0,000 0,14164706 0,16030236 ! formation of primary germ layer GO:0001704 72 33 0,000 0,14164706 0,160227 ! cell fate specification GO:0001708 52 33 0,000 0,14164706 0,1601517 ! sterol transport GO:0015918 57 33 0,000 0,14164706 0,16007648 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,14164706 0,16000133 ! adult locomotory behavior GO:0008344 59 33 0,000 0,14164706 0,15992624 ! negative regulation of protein transport GO:0051224 69 33 0,000 0,14164706 0,15985123 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,14164706 0,15977629 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,14561299 0,16417285 ! glial cell differentiation GO:0010001 63 34 0,000 0,14561299 0,16409595 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,14561299 0,16401913 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,14561299 0,16394237 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,14561299 0,16386569 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,14561299 0,16378909 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,14561299 0,16371255 ! mismatch repair GO:0006298 46 34 0,000 0,14561299 0,16363608 ! spermatid development GO:0007286 63 34 0,000 0,14561299 0,16355969 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,14561299 0,16348337 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,14561299 0,16340711 ! placenta development GO:0001890 53 34 0,000 0,14561299 0,16333093 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,14956073 0,16768085 ! odontogenesis GO:0042476 66 35 0,000 0,14956073 0,16760275 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,14956073 0,16752473 ! female gonad development GO:0008585 58 35 0,000 0,14956073 0,16744677 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,14956073 0,16736889 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 59 35 0,000 0,14956073 0,16729108 ! regulation of microtubule-based process GO:0032886 78 35 0,000 0,14956073 0,16721334 ! vesicle localization GO:0051648 64 35 0,000 0,14956073 0,16713568 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,15349036 0,17144744 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,15349036 0,17136789 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,15349036 0,1712884 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,15349036 0,17120899 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,15349036 0,17112965 ! positive regulation of cell development GO:0010720 80 36 0,000 0,15349036 0,17105039 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,15349036 0,1709712 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,15349036 0,17089208 ! aerobic respiration GO:0009060 55 36 0,000 0,15349036 0,17081304 ! RNA export from nucleus GO:0006405 56 37 0,000 0,15740196 0,17508512 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,15740196 0,17500421 ! actomyosin structure organization GO:0031032 62 37 0,000 0,15740196 0,17492337 ! organic anion transport GO:0015711 68 37 0,000 0,15740196 0,17484262 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,15740196 0,17476193 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,15740196 0,17468132 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,15740196 0,17460079 GO:0015986|ATP synthesis coupled proton transport, ! pigment metabolic process GO:0042440 80 37 0,000 0,15740196 0,17452032 ! spermatid differentiation GO:0048515 66 37 0,000 0,15740196 0,17443994 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,16129561 0,17867276 GO:0006956|complement activation, ! regulation of neuron projection development GO:0010975 91 38 0,000 0,16129561 0,17859054 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,16129561 0,17850839 ! lipid homeostasis GO:0055088 67 38 0,000 0,16129561 0,17842632 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,16129561 0,17834432 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,16129561 0,1782624 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,16129561 0,17818055 ! mRNA catabolic process GO:0006402 71 39 0,000 0,1651714 0,18237833 ! learning GO:0007612 77 39 0,000 0,1651714 0,18229467 ! organic ether metabolic process GO:0018904 55 39 0,000 0,1651714 0,18221109 ! development of primary male sexual characteristics GO:0046546 66 39 0,000 0,1651714 0,18212758 ! ion transmembrane transport GO:0034220 66 39 0,000 0,1651714 0,18204415 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,1651714 0,1819608 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,1651714 0,18187752 ! RNA modification GO:0009451 57 39 0,000 0,1651714 0,18179432 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,1651714 0,1817112 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,16902941 0,18587055 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,16902941 0,18578564 ! feeding behavior GO:0007631 59 40 0,000 0,16902941 0,1857008 ! multicellular organismal metabolic process GO:0044236 57 40 0,000 0,16902941 0,18561605 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,16902941 0,18553137 ! maintenance of protein location GO:0045185 91 40 0,000 0,16902941 0,18544677 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,17286972 0,18957363 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,17286972 0,18948726 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,17286972 0,18940097 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,17286972 0,18931476 ! gliogenesis GO:0042063 88 41 0,000 0,17286972 0,18922863 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,17286972 0,18914258 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,17286972 0,18905661 ! female gamete generation GO:0007292 61 41 0,000 0,17286972 0,18897071 ! polyol metabolic process GO:0019751 66 41 0,000 0,17286972 0,18888489 ! dorsal/ventral pattern formation GO:0009953 68 41 0,000 0,17286972 0,18879915 ! negative regulation of protein complex disassembly GO:0043242 101 42 0,000 0,1766924 0,19288653 ! regulation of tube size GO:0035150 71 42 0,000 0,1766924 0,19279906 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,1766924 0,19271166 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,1766924 0,19262434 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,1766924 0,1925371 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,1766924 0,19244994 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,18049755 0,19650548 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,18049755 0,1964166 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,18049755 0,1963278 ! glucose transport GO:0015758 65 43 0,000 0,18049755 0,19623909 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,18049755 0,19615045 ! striated muscle contraction GO:0006941 77 43 0,000 0,18049755 0,1960619 ! phagocytosis GO:0006909 90 43 0,000 0,18049755 0,19597342 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,18049755 0,19588502 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,18428523 0,19990544 ! hexose transport GO:0008645 67 44 0,000 0,18428523 0,19981535 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,18428523 0,19972535 ! male sex differentiation GO:0046661 76 44 0,000 0,18428523 0,19963542 ! biopolymer methylation GO:0043414 84 44 0,000 0,18428523 0,19954558 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,18428523 0,19945581 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,18428523 0,19936613 ! maintenance of location in cell GO:0051651 97 44 0,000 0,18428523 0,19927653 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,18805554 0,20326218 ! glycolysis GO:0006096 65 45 0,000 0,18805554 0,20317091 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,18805554 0,20307972 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,18805554 0,20298861 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,18805554 0,20289759 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,18805554 0,20280664 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,18805554 0,20271578 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,18805554 0,202625 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,19180854 0,20657625 ! negative regulation of cell migration GO:0030336 115 46 0,000 0,19180854 0,20648382 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,19180854 0,20639148 ! response to calcium ion GO:0051592 81 47 0,000 0,19554432 0,21031722 ! endosome transport GO:0016197 108 47 0,000 0,19554432 0,21022325 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,19554432 0,21012936 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,19554432 0,21003555 ! JNK cascade GO:0007254 91 47 0,000 0,19554432 0,20994182 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,19554432 0,20984818 ! methylation GO:0032259 90 47 0,000 0,19554432 0,20975463 ! protein homooligomerization GO:0051260 76 47 0,000 0,19554432 0,20966115 ! Notch signaling pathway GO:0007219 96 48 0,000 0,19926295 0,21355308 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,19926295 0,213458 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,19926295 0,213363 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,19926295 0,21326809 ! regulation of protein complex disassembly GO:0043244 113 49 0,000 0,20296452 0,21713323 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,20296452 0,21703673 ! regulation of ion transport GO:0043269 77 49 0,000 0,20296452 0,21694031 ! response to temperature stimulus GO:0009266 76 49 0,000 0,20296452 0,21684398 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,20296452 0,21674773 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,20296452 0,21665157 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,20296452 0,21655549 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,20296452 0,2164595 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,2066491 0,22029142 ! regulation of ossification GO:0030278 117 50 0,000 0,2066491 0,22019386 ! inner ear development GO:0048839 79 50 0,000 0,2066491 0,22009639 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,2066491 0,219999 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,2066491 0,2199017 ! viral infectious cycle GO:0019058 99 51 0,000 0,21031677 0,22370563 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,21031677 0,22360678 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,21031677 0,22350801 ! excretion GO:0007588 83 51 0,000 0,21031677 0,22340934 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,21031677 0,22331074 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,21031677 0,22321224 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,21031677 0,22311382 ! vesicle organization GO:0016050 107 51 0,000 0,21031677 0,22301549 ! amino acid activation GO:0043038 92 52 0,000 0,2139676 0,22678681 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 76 53 0,000 0,21760168 0,23053705 ! RNA catabolic process GO:0006401 93 53 0,000 0,21760168 0,23043558 ! regulation of translational initiation GO:0006446 82 53 0,000 0,21760168 0,2303342 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,21760168 0,23023291 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,21760168 0,23013171 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,21760168 0,2300306 ! negative regulation of cytoskeleton organization GO:0051494 124 54 0,000 0,22121907 0,23375191 ! cell recognition GO:0008037 85 54 0,000 0,22121907 0,23364929 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,22121907 0,23354677 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,22121907 0,23344434 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,22121907 0,233342 ! chloride transport GO:0006821 90 55 0,000 0,22481986 0,23703619 ! glucose catabolic process GO:0006007 82 55 0,000 0,22481986 0,23693237 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,22481986 0,23682863 ! gastrulation GO:0007369 112 55 0,000 0,22481986 0,23672499 ! regulation of multicellular organism growth GO:0040014 85 55 0,000 0,22481986 0,23662143 ! RNA elongation GO:0006354 79 55 0,000 0,22481986 0,23651797 ! nuclear export GO:0051168 97 55 0,000 0,22481986 0,23641459 ! negative regulation of cell motion GO:0051271 134 55 0,000 0,22481986 0,23631131 ! regulation of actin filament length GO:0030832 105 56 0,000 0,22840412 0,23997394 ! sensory perception of smell GO:0007608 80 56 0,000 0,22840412 0,23986919 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,22840412 0,23976454 ! proton transport GO:0015992 94 56 0,000 0,22840412 0,23965997 ! maintenance of location GO:0051235 118 57 0,000 0,23197193 0,2432975 ! hydrogen transport GO:0006818 97 58 0,000 0,23552336 0,24691468 ! regulation of endocytosis GO:0030100 91 58 0,000 0,23552336 0,24680714 ! adult behavior GO:0030534 99 58 0,000 0,23552336 0,24669969 ! regulation of cellular component size GO:0032535 109 59 0,000 0,23905848 0,2502936 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,23905848 0,25018473 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,23905848 0,25007596 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,24257737 0,25364674 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,24608011 0,25719754 ! mesoderm development GO:0007498 119 61 0,000 0,24608011 0,25708586 ! tRNA processing GO:0008033 89 61 0,000 0,24608011 0,25697428 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,24608011 0,25686279 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,24956676 0,26038926 ! gonad development GO:0008406 98 62 0,000 0,24956676 0,26027639 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,25303741 0,26378163 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,25303741 0,26366739 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,25303741 0,26355325 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,25649212 0,26703593 ! cell redox homeostasis GO:0045454 102 64 0,000 0,25649212 0,26692043 ! multicellular organism reproduction GO:0032504 111 64 0,000 0,25649212 0,26680503 GO:0048609|reproductive process in a multicellular organism, ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,25993096 0,27026529 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,25993096 0,27014855 ! germ cell development GO:0007281 118 65 0,000 0,25993096 0,2700319 ! myeloid cell differentiation GO:0030099 111 65 0,000 0,25993096 0,26991536 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,26335401 0,27335192 ! actin filament organization GO:0007015 148 66 0,000 0,26335401 0,27323405 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,26335401 0,27311627 ! extracellular matrix organization GO:0030198 133 66 0,000 0,26335401 0,2729986 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,26676135 0,27641163 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,26676135 0,27629264 ! homeostasis of number of cells GO:0048872 114 67 0,000 0,26676135 0,27617375 ! hexose catabolic process GO:0019320 104 67 0,000 0,26676135 0,27605497 ! positive regulation of T cell activation GO:0050870 109 67 0,000 0,26676135 0,27593629 ! activation of immune response GO:0002253 105 67 0,000 0,26676135 0,27581771 ! amino acid transport GO:0006865 125 68 0,000 0,27015303 0,27920455 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,27015303 0,27908467 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,27015303 0,27896489 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,27015303 0,27884522 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,27352914 0,28220888 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,27352914 0,28208792 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,27352914 0,28196706 ! antigen processing and presentation GO:0019882 104 69 0,000 0,27352914 0,2818463 ! amine catabolic process GO:0009310 117 71 0,000 0,28023492 0,28863237 ! humoral immune response GO:0006959 109 71 0,000 0,28023492 0,28850886 ! regulation of MAPKKK cascade GO:0043408 142 71 0,000 0,28023492 0,28838546 ! acute inflammatory response GO:0002526 113 72 0,000 0,28356472 0,29168736 ! carbohydrate transport GO:0008643 110 72 0,000 0,28356472 0,2915627 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,28356472 0,29143816 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,28356472 0,29131372 ! regulation of blood pressure GO:0008217 125 73 0,000 0,28687924 0,29459302 ! transition metal ion transport GO:0000041 126 74 0,000 0,29017852 0,29785389 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,29017852 0,29772688 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,29346266 0,30096809 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,29346266 0,30083986 ! rhythmic process GO:0048511 128 75 0,000 0,29346266 0,30071173 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,2967317 0,30393209 ! defense response to bacterium GO:0042742 89 76 0,000 0,2967317 0,30380275 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,2967317 0,30367353 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,2967317 0,30354442 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,29998573 0,30674274 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,29998573 0,30661243 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,29998573 0,30648224 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,30322481 0,30965997 ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,30322481 0,30952859 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,30644901 0,31268716 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,30644901 0,31255461 ! regulation of synaptic transmission GO:0050804 134 79 0,000 0,30644901 0,31242217 ! regulation of adenylate cyclase activity GO:0045761 156 80 0,000 0,3096584 0,3155604 ! response to metal ion GO:0010038 140 80 0,000 0,3096584 0,3154268 ! muscle cell differentiation GO:0042692 159 80 0,000 0,3096584 0,31529332 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,3096584 0,31515994 ! inorganic anion transport GO:0015698 138 80 0,000 0,3096584 0,31502668 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,31285304 0,31814219 ! regulation of cAMP biosynthetic process GO:0030817 161 82 0,000 0,31603301 0,32124014 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,31603301 0,32110448 ! regulation of cyclase activity GO:0031279 159 82 0,000 0,31603301 0,32096894 ! regulation of lyase activity GO:0051339 160 83 0,000 0,31919836 0,32404694 ! regulation of cAMP metabolic process GO:0030814 168 84 0,000 0,32234917 0,32710759 ! regulation of transmission of nerve impulse GO:0051969 141 84 0,000 0,32234917 0,32696969 ! response to unfolded protein GO:0006986 131 85 0,000 0,3254855 0,33001185 ! nucleosome assembly GO:0006334 122 85 0,000 0,3254855 0,32987284 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,3254855 0,32973395 ! amine biosynthetic process GO:0009309 138 86 0,000 0,32860742 0,33275651 ! response to inorganic substance GO:0010035 153 86 0,000 0,32860742 0,33261652 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,32860742 0,33247665 ! chromatin assembly GO:0031497 124 86 0,000 0,32860742 0,33233689 ! alcohol catabolic process GO:0046164 130 86 0,000 0,32860742 0,33219725 ! amine transport GO:0015837 155 86 0,000 0,32860742 0,33205773 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 0,000 0,331715 0,33505721 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,331715 0,33491661 ! cellular respiration GO:0045333 135 88 0,000 0,33480829 0,33789797 ! regulation of neurological system process GO:0031644 148 88 0,000 0,33480829 0,33775629 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,33480829 0,33761473 ! cellular defense response GO:0006968 114 89 0,000 0,33788737 0,34057688 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 0,000 0,3409523 0,34352229 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,3409523 0,3433785 ! sterol metabolic process GO:0016125 152 91 0,000 0,34400314 0,34630609 ! response to protein stimulus GO:0051789 149 91 0,000 0,34400314 0,34616125 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,34400314 0,34601654 ! nucleosome organization GO:0034728 138 92 0,000 0,34703996 0,34892526 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,35006282 0,35181752 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 0,000 0,35006282 0,35167063 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,35307179 0,35454538 ! female pregnancy GO:0007565 164 94 0,000 0,35307179 0,35439747 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,3590483 0,36024613 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,3590483 0,36009596 ! positive regulation of immune response GO:0050778 156 96 0,000 0,3590483 0,35994592 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,36201597 0,36276985 ! protein ubiquitination GO:0016567 217 97 0,000 0,36201597 0,36261882 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,36496999 0,36542563 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,36496999 0,36527362 GO:0016054|organic acid catabolic process, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,36791043 0,36806341 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,36791043 0,36791043