pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6709-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 8,000 1,831E-09 4,211E-06 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 6,000 2,786E-09 3,204E-06 ! negative regulation of phosphorylation GO:0042326 41 23 5,000 8,372E-08 6,419E-05 ! cell growth GO:0016049 61 39 6,000 1,09E-07 6,269E-05 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 1,444E-07 6,645E-05 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cell adhesion GO:0030155 159 83 8,000 1,501E-07 5,755E-05 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 7,000 2,174E-07 7,144E-05 ! induction of positive chemotaxis GO:0050930 14 8 3,000 6,734E-07 1,936E-04 ! regulation of protein stability GO:0031647 48 32 5,000 6,971E-07 1,782E-04 ! negative regulation of cell adhesion GO:0007162 67 33 5,000 8,45E-07 1,943E-04 ! positive regulation of locomotion GO:0040017 35 20 4,000 1,34E-06 2,802E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 4,000 1,745E-06 3,344E-04 ! regulation of B cell proliferation GO:0030888 15 10 3,000 1,989E-06 3,518E-04 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 3,000 1,989E-06 3,267E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 1,989E-06 3,049E-04 ! regulation of cell-matrix adhesion GO:0001952 51 22 4,000 2,239E-06 3,219E-04 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 38 22 4,000 2,239E-06 3,03E-04 ! regulation of homeostatic process GO:0032844 105 60 6,000 2,292E-06 2,928E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 5,000 2,368E-06 2,866E-04 ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 2,447E-06 2,814E-04 ! interphase GO:0051325 159 88 7,000 2,914E-06 3,192E-04 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 3,101E-06 3,241E-04 GO:0050927|positive regulation of positive chemotaxis, ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 4,279E-06 4,279E-04 ! negative regulation of cell migration GO:0030336 92 44 5,000 4,914E-06 4,709E-04 ! negative regulation of protein modification process GO:0031400 50 26 4,000 5,414E-06 4,981E-04 ! positive regulation of phosphorylation GO:0042327 102 70 6,000 6,537E-06 5,783E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 6,613E-06 5,633E-04 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 7,000 7,067E-06 5,805E-04 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 6,000 7,898E-06 6,264E-04 GO:0045937|positive regulation of phosphate metabolic process, ! C21-steroid hormone biosynthetic process GO:0006700 15 14 3,000 9,185E-06 7,042E-04 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 2,000 9,884E-06 7,333E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 9,884E-06 7,104E-04 ! positive regulation of cell migration GO:0030335 92 51 5,000 1,183E-05 8,242E-04 ! negative regulation of cell motion GO:0051271 104 51 5,000 1,183E-05 8E-04 ! regulation of protein ubiquitination GO:0031396 19 15 3,000 1,243E-05 8,166E-04 ! regulation of cell cycle process GO:0010564 122 81 6,000 1,728E-05 1,104E-03 ! positive regulation of protein ubiquitination GO:0031398 8 6 2,000 1,962E-05 1,22E-03 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 1,962E-05 1,188E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 1,962E-05 1,157E-03 ! positive regulation of cell motion GO:0051272 99 56 5,000 2,045E-05 1,176E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 5,000 2,267E-05 1,272E-03 ! negative regulation of kinase activity GO:0033673 100 58 5,000 2,507E-05 1,373E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 2,721E-05 1,455E-03 ! negative regulation of transferase activity GO:0051348 105 61 5,000 3,355E-05 1,754E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 3,408E-05 1,742E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 3,408E-05 1,704E-03 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 3,408E-05 1,668E-03 ! C21-steroid hormone metabolic process GO:0008207 23 19 3,000 3,419E-05 1,638E-03 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 3,000 3,419E-05 1,605E-03 ! sex determination GO:0007530 29 19 3,000 3,419E-05 1,573E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 5,000 4,419E-05 1,993E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 4,832E-05 2,137E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 4,832E-05 2,097E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 5,413E-05 2,305E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 2,000 5,413E-05 2,264E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 5,413E-05 2,223E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 5,413E-05 2,184E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 5,413E-05 2,146E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 5,413E-05 2,11E-03 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 5,413E-05 2,075E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 5,413E-05 2,041E-03 ! regulation of T cell differentiation GO:0045580 59 41 4,000 5,459E-05 2,025E-03 ! lymphocyte proliferation GO:0046651 36 23 3,000 7,57E-05 2,763E-03 ! regulation of mast cell proliferation GO:0070666 64 44 4,000 7,72E-05 2,775E-03 ! negative regulation of striated muscle development GO:0045843 11 9 2,000 8,059E-05 2,852E-03 ! T cell selection GO:0045058 18 9 2,000 8,059E-05 2,808E-03 ! motor axon guidance GO:0008045 14 9 2,000 8,059E-05 2,767E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 8,059E-05 2,726E-03 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 2,000 8,059E-05 2,686E-03 ! blastocyst formation GO:0001825 12 9 2,000 8,059E-05 2,648E-03 ! embryonic placenta development GO:0001892 12 9 2,000 8,059E-05 2,611E-03 ! response to hypoxia GO:0001666 132 72 5,000 8,616E-05 2,752E-03 ! response to oxygen levels GO:0070482 137 74 5,000 1,005E-04 3,166E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 4,000 1,064E-04 3,308E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! leukocyte proliferation GO:0070661 39 25 3,000 1,064E-04 3,264E-03 GO:0032943|mononuclear cell proliferation, ! negative regulation of muscle development GO:0048635 12 10 2,000 1,143E-04 3,458E-03 ! hippocampus development GO:0021766 19 10 2,000 1,143E-04 3,413E-03 ! protein sumoylation GO:0016925 12 10 2,000 1,143E-04 3,37E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 2,000 1,143E-04 3,327E-03 ! regulation of lymphocyte differentiation GO:0045619 69 48 4,000 1,178E-04 3,388E-03 ! cartilage development GO:0051216 70 49 4,000 1,302E-04 3,696E-03 ! positive regulation of protein modification process GO:0031401 107 78 5,000 1,348E-04 3,78E-03 ! ear development GO:0043583 72 50 4,000 1,435E-04 3,975E-03 ! lipid modification GO:0030258 73 50 4,000 1,435E-04 3,928E-03 ! forebrain development GO:0030900 131 80 5,000 1,551E-04 4,196E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 1,56E-04 4,171E-03 ! T cell proliferation GO:0042098 20 11 2,000 1,56E-04 4,123E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 1,56E-04 4,076E-03 ! focal adhesion formation GO:0048041 24 11 2,000 1,56E-04 4,031E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 1,56E-04 3,986E-03 ! regulation of leukocyte migration GO:0002685 24 11 2,000 1,56E-04 3,942E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 1,56E-04 3,899E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,56E-04 3,857E-03 GO:0042130|negative regulation of T cell proliferation, ! placenta development GO:0001890 37 28 3,000 1,683E-04 4,118E-03 ! regulation of B cell activation GO:0050864 42 28 3,000 1,683E-04 4,074E-03 ! regulation of mitosis GO:0007088 84 54 4,000 2,073E-04 4,966E-03 GO:0051783|regulation of nuclear division, ! regulation of DNA metabolic process GO:0051052 135 85 5,000 2,166E-04 5,135E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 5,000 2,166E-04 5,082E-03 ! regulation of striated muscle tissue development GO:0016202 47 31 3,000 2,526E-04 5,868E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 2,664E-04 6,126E-03 ! cellular pigmentation GO:0033059 24 13 2,000 2,664E-04 6,066E-03 ! reproductive developmental process GO:0003006 127 89 5,000 2,784E-04 6,277E-03 ! regulation of muscle development GO:0048634 48 32 3,000 2,864E-04 6,396E-03 ! hormone biosynthetic process GO:0042446 45 33 3,000 3,234E-04 7,152E-03 ! G1 phase of mitotic cell cycle GO:0000080 23 14 2,000 3,365E-04 7,371E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 3,365E-04 7,301E-03 ! inositol metabolic process GO:0006020 20 14 2,000 3,365E-04 7,233E-03 ! limbic system development GO:0021761 25 14 2,000 3,365E-04 7,166E-03 ! negative regulation of microtubule depolymerization GO:0007026 31 14 2,000 3,365E-04 7,101E-03 GO:0031114|regulation of microtubule depolymerization, ! T cell differentiation in the thymus GO:0033077 27 14 2,000 3,365E-04 7,036E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 3,365E-04 6,973E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 3,365E-04 6,91E-03 ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 3,365E-04 6,849E-03 ! cell-matrix adhesion GO:0007160 114 61 4,000 3,684E-04 7,434E-03 ! angiogenesis GO:0001525 149 95 5,000 3,962E-04 7,923E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 4,175E-04 8,278E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 4,175E-04 8,208E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 4,175E-04 8,138E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 4,175E-04 8,07E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 4,175E-04 8,003E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 4,175E-04 7,936E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 2,000 4,175E-04 7,871E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 2,000 4,175E-04 7,807E-03 ! in utero embryonic development GO:0001701 147 96 5,000 4,191E-04 7,773E-03 ! endothelial cell migration GO:0043542 22 16 2,000 5,101E-04 9,385E-03 ! regulation of protein binding GO:0043393 27 16 2,000 5,101E-04 9,311E-03 ! G1 phase GO:0051318 27 16 2,000 5,101E-04 9,238E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 5,101E-04 9,166E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 5,101E-04 9,094E-03 ! cell-substrate adhesion GO:0031589 121 66 4,000 5,315E-04 9,404E-03 ! regulation of T cell proliferation GO:0042129 58 38 3,000 5,61E-04 9,849E-03 ! mesenchymal cell development GO:0014031 64 38 3,000 5,61E-04 9,774E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 3,000 5,61E-04 9,701E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 6,148E-04 0,01055275 ! cell-substrate junction assembly GO:0007044 39 17 2,000 6,148E-04 0,01047458 ! peptidyl-serine modification GO:0018209 27 17 2,000 6,148E-04 0,01039757 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 6,148E-04 0,01032167 ! JAK-STAT cascade GO:0007259 53 40 3,000 6,837E-04 0,01139552 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 7,323E-04 0,01211775 ! somitogenesis GO:0001756 24 18 2,000 7,323E-04 0,0120312 ! regulation of glucose import GO:0046324 21 18 2,000 7,323E-04 0,01194587 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 7,323E-04 0,01186174 ! regulation of cell shape GO:0008360 78 42 3,000 8,244E-04 0,0132597 ! response to alkaloid GO:0043279 32 19 2,000 8,632E-04 0,01378778 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 8,632E-04 0,0136927 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 8,632E-04 0,01359891 ! apoptotic nuclear changes GO:0030262 24 19 2,000 8,632E-04 0,0135064 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 8,632E-04 0,01341514 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 8,632E-04 0,01332511 ! vesicle organization GO:0016050 79 43 3,000 9,019E-04 0,01382892 ! negative regulation of growth GO:0045926 123 75 4,000 9,545E-04 0,01453936 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 9,879E-04 0,01494891 ! autophagic vacuole formation GO:0000045 8 5 1,000 9,879E-04 0,0148512 ! negative regulation of bone resorption GO:0045779 10 5 1,000 9,879E-04 0,01475477 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 9,879E-04 0,01465958 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 1,000 9,879E-04 0,0145656 ! negative regulation of cell-cell adhesion GO:0022408 11 5 1,000 9,879E-04 0,01447283 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 9,879E-04 0,01438123 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 9,879E-04 0,01429078 ! embryonic hemopoiesis GO:0035162 10 5 1,000 9,879E-04 0,01420146 ! positive regulation of glycolysis GO:0045821 11 5 1,000 9,879E-04 0,01411326 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 9,879E-04 0,01402614 ! valine metabolic process GO:0006573 8 5 1,000 9,879E-04 0,01394009 ! paraxial mesoderm development GO:0048339 9 5 1,000 9,879E-04 0,01385509 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 9,879E-04 0,01377112 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 9,879E-04 0,01368816 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 9,879E-04 0,01360619 GO:0045686|negative regulation of glial cell differentiation, ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 9,879E-04 0,0135252 GO:0002707|negative regulation of lymphocyte mediated immunity, ! cranial nerve morphogenesis GO:0021602 6 5 1,000 9,879E-04 0,01344517 ! positive regulation of chemokine production GO:0032722 7 5 1,000 9,879E-04 0,01336608 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 9,879E-04 0,01328792 ! apical protein localization GO:0045176 6 5 1,000 9,879E-04 0,01321066 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 1,000 9,879E-04 0,0131343 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 9,879E-04 0,01305882 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 9,879E-04 0,0129842 ! regulation of sensory perception GO:0051931 6 5 1,000 9,879E-04 0,01291042 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 9,879E-04 0,01283748 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 9,879E-04 0,01276536 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! pallium development GO:0021543 38 20 2,000 1,008E-03 0,01295308 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 1,008E-03 0,01288112 ! positive regulation of B cell activation GO:0050871 31 20 2,000 1,008E-03 0,01280995 ! gland development GO:0048732 148 77 4,000 1,075E-03 0,01358798 ! histone modification GO:0016570 68 46 3,000 1,165E-03 0,01464141 ! response to UV GO:0009411 75 46 3,000 1,165E-03 0,01456183 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,167E-03 0,01451412 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 1,167E-03 0,01443609 ! dendrite development GO:0016358 35 21 2,000 1,167E-03 0,01435889 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,167E-03 0,01428251 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 1,167E-03 0,01420694 ! response to cytokine stimulus GO:0034097 47 21 2,000 1,167E-03 0,01413217 ! T cell activation GO:0042110 134 79 4,000 1,207E-03 0,01453294 ! covalent chromatin modification GO:0016569 75 47 3,000 1,263E-03 0,01513465 ! negative regulation of immune system process GO:0002683 73 47 3,000 1,263E-03 0,01505623 ! vasculogenesis GO:0001570 33 22 2,000 1,342E-03 0,01590819 ! blastocyst development GO:0001824 37 22 2,000 1,342E-03 0,01582661 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 3,000 1,368E-03 0,01604787 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,472E-03 0,01718674 ! prostate gland development GO:0030850 9 6 1,000 1,472E-03 0,01709993 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,472E-03 0,017014 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,472E-03 0,01692893 ! mRNA stabilization GO:0048255 15 6 1,000 1,472E-03 0,01684471 GO:0043489|RNA stabilization, ! thymic T cell selection GO:0045061 12 6 1,000 1,472E-03 0,01676132 ! pigment granule organization GO:0048753 11 6 1,000 1,472E-03 0,01667875 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 1,472E-03 0,01659699 ! ER overload response GO:0006983 7 6 1,000 1,472E-03 0,01651603 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,472E-03 0,01643586 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,472E-03 0,01635646 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 1,472E-03 0,01627782 ! macroautophagy GO:0016236 10 6 1,000 1,472E-03 0,01619994 ! gas homeostasis GO:0033483 11 6 1,000 1,472E-03 0,01612279 ! dendrite morphogenesis GO:0048813 9 6 1,000 1,472E-03 0,01604638 ! regulation of interleukin-13 production GO:0032656 11 6 1,000 1,472E-03 0,01597069 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,472E-03 0,01589571 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 1,472E-03 0,01582143 GO:0043011|myeloid dendritic cell differentiation, ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,472E-03 0,01574785 ! integrin-mediated signaling pathway GO:0007229 81 49 3,000 1,478E-03 0,01573315 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,532E-03 0,01623504 ! cellular response to oxidative stress GO:0034599 33 23 2,000 1,532E-03 0,01616056 ! positive regulation of growth GO:0045927 67 50 3,000 1,594E-03 0,01673597 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 1,738E-03 0,01816671 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 1,738E-03 0,01808451 ! regulation of alpha-beta T cell activation GO:0046634 35 24 2,000 1,738E-03 0,01800305 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 1,738E-03 0,01792232 ! iron ion homeostasis GO:0055072 39 25 2,000 1,96E-03 0,0201263 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,96E-03 0,02003685 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,96E-03 0,01994819 ! skeletal system morphogenesis GO:0048705 78 53 3,000 1,979E-03 0,02005536 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,047E-03 0,02065239 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 2,047E-03 0,02056221 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 2,047E-03 0,02047281 ! microtubule bundle formation GO:0001578 8 7 1,000 2,047E-03 0,02038418 ! T-helper 1 type immune response GO:0042088 11 7 1,000 2,047E-03 0,02029632 ! positive regulation of isotype switching GO:0045830 15 7 1,000 2,047E-03 0,02020921 GO:0045911|positive regulation of DNA recombination, ! hemoglobin metabolic process GO:0020027 10 7 1,000 2,047E-03 0,02012284 ! regulation of pigmentation during development GO:0048070 15 7 1,000 2,047E-03 0,02003722 ! central nervous system neuron axonogenesis GO:0021955 14 7 1,000 2,047E-03 0,01995231 GO:0021952|central nervous system projection neuron axonogenesis, ! asymmetric protein localization GO:0008105 8 7 1,000 2,047E-03 0,01986812 ! organ growth GO:0035265 11 7 1,000 2,047E-03 0,01978465 ! behavioral fear response GO:0001662 13 7 1,000 2,047E-03 0,01970186 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 2,047E-03 0,01961977 ! B cell lineage commitment GO:0002326 17 7 1,000 2,047E-03 0,01953836 ! regulation of interleukin-10 production GO:0032653 11 7 1,000 2,047E-03 0,01945763 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 2,047E-03 0,01937755 ! T cell lineage commitment GO:0002360 12 7 1,000 2,047E-03 0,01929814 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 2,047E-03 0,01921937 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 1,000 2,047E-03 0,01914124 ! neuroblast proliferation GO:0007405 13 7 1,000 2,047E-03 0,01906375 ! peptidyl-threonine modification GO:0018210 18 7 1,000 2,047E-03 0,01898688 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 2,047E-03 0,01891062 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 2,047E-03 0,01883498 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 2,047E-03 0,01875994 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 2,047E-03 0,0186855 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 2,047E-03 0,01861164 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 2,047E-03 0,01853837 ! regulation of T cell activation GO:0050863 128 89 4,000 2,051E-03 0,01849627 ! DNA catabolic process GO:0006308 67 54 3,000 2,121E-03 0,01905714 ! leukocyte differentiation GO:0002521 143 90 4,000 2,154E-03 0,01927617 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 2,2E-03 0,01960808 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 2,2E-03 0,01953237 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 2,425E-03 0,02145559 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 2,456E-03 0,02164539 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 2,486E-03 0,02182664 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 2,588E-03 0,02263488 ! axon extension GO:0048675 11 8 1,000 2,712E-03 0,02362435 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 2,712E-03 0,0235352 ! succinate metabolic process GO:0006105 14 8 1,000 2,712E-03 0,02344673 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,712E-03 0,02335891 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,712E-03 0,02327175 ! melanin metabolic process GO:0006582 12 8 1,000 2,712E-03 0,02318524 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,712E-03 0,02309937 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,712E-03 0,02301413 ! regulation of gliogenesis GO:0014013 20 8 1,000 2,712E-03 0,02292952 GO:0045685|regulation of glial cell differentiation, ! regulation of interleukin-4 production GO:0032673 16 8 1,000 2,712E-03 0,02284553 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,712E-03 0,02276215 ! induction of an organ GO:0001759 11 8 1,000 2,712E-03 0,02267938 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,712E-03 0,02259721 ! regulation of embryonic development GO:0045995 16 8 1,000 2,712E-03 0,02251563 ! regulation of binding GO:0051098 151 95 4,000 2,728E-03 0,02256739 ! cell junction assembly GO:0034329 56 28 2,000 2,731E-03 0,02251231 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,731E-03 0,02243191 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 2,731E-03 0,02235208 ! myeloid leukocyte activation GO:0002274 39 28 2,000 2,731E-03 0,02227282 ! regulation of response to external stimulus GO:0032101 139 96 4,000 2,855E-03 0,02319959 ! activation of MAPK activity GO:0000187 84 59 3,000 2,936E-03 0,02377851 ! lung development GO:0030324 94 59 3,000 2,936E-03 0,02369507 ! telencephalon development GO:0021537 52 29 2,000 3,024E-03 0,02431558 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 3,121E-03 0,02501546 ! hindbrain development GO:0030902 45 30 2,000 3,335E-03 0,02663294 ! regulation of microtubule-based process GO:0032886 58 30 2,000 3,335E-03 0,02654078 ! negative regulation of cell activation GO:0050866 44 30 2,000 3,335E-03 0,02644926 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,463E-03 0,02737395 ! regulation of glycolysis GO:0006110 15 9 1,000 3,463E-03 0,02728021 ! lung alveolus development GO:0048286 17 9 1,000 3,463E-03 0,0271871 ! phosphagen metabolic process GO:0006599 12 9 1,000 3,463E-03 0,02709463 GO:0006600|creatine metabolic process, ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 3,463E-03 0,02700278 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 3,463E-03 0,02691156 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 3,463E-03 0,02682094 GO:0002820|negative regulation of adaptive immune response, ! oocyte differentiation GO:0009994 12 9 1,000 3,463E-03 0,02673094 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 3,463E-03 0,02664154 ! spleen development GO:0048536 15 9 1,000 3,463E-03 0,02655273 ! response to nicotine GO:0035094 16 9 1,000 3,463E-03 0,02646452 ! localization within membrane GO:0051668 15 9 1,000 3,463E-03 0,02637689 ! cellular hormone metabolic process GO:0034754 87 62 3,000 3,516E-03 0,02668815 ! negative regulation of cell growth GO:0030308 106 62 3,000 3,516E-03 0,02660036 ! respiratory tube development GO:0030323 99 62 3,000 3,516E-03 0,02651315 ! mammary gland development GO:0030879 57 31 2,000 3,665E-03 0,02754855 ! segmentation GO:0035282 41 31 2,000 3,665E-03 0,02745881 ! leukocyte chemotaxis GO:0030595 43 31 2,000 3,665E-03 0,02736966 GO:0060326|cell chemotaxis, ! negative regulation of cell size GO:0045792 108 64 3,000 3,943E-03 0,02934786 ! respiratory system development GO:0060541 100 64 3,000 3,943E-03 0,02925319 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 4,301E-03 0,03180568 ! hair follicle morphogenesis GO:0031069 17 10 1,000 4,301E-03 0,03170374 ! blood vessel remodeling GO:0001974 21 10 1,000 4,301E-03 0,03160245 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 4,301E-03 0,0315018 ! B cell proliferation GO:0042100 14 10 1,000 4,301E-03 0,0314018 ! fear response GO:0042596 16 10 1,000 4,301E-03 0,03130242 ! negative regulation of ossification GO:0030279 19 10 1,000 4,301E-03 0,03120368 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 4,301E-03 0,03110555 ! regulation of bone resorption GO:0045124 24 10 1,000 4,301E-03 0,03100804 ! alpha-beta T cell activation GO:0046631 16 10 1,000 4,301E-03 0,03091114 ! regulation of B cell differentiation GO:0045577 16 10 1,000 4,301E-03 0,03081485 ! cranial nerve development GO:0021545 12 10 1,000 4,301E-03 0,03071915 ! DNA methylation GO:0006306 15 10 1,000 4,301E-03 0,03062404 GO:0006305|DNA alkylation, ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 4,301E-03 0,03052952 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 4,301E-03 0,03043559 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 4,301E-03 0,03034223 ! negative regulation of immune effector process GO:0002698 16 10 1,000 4,301E-03 0,03024944 ! cell junction organization GO:0034330 63 33 2,000 4,384E-03 0,03074011 ! nucleus organization GO:0006997 49 33 2,000 4,384E-03 0,03064668 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 4,384E-03 0,03055381 ! cytokinesis GO:0000910 52 33 2,000 4,384E-03 0,0304615 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 4,773E-03 0,03306496 ! neuron migration GO:0001764 46 34 2,000 4,773E-03 0,03296567 ! polyol metabolic process GO:0019751 44 34 2,000 4,773E-03 0,03286697 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 4,773E-03 0,03276886 ! Notch signaling pathway GO:0007219 56 35 2,000 5,182E-03 0,03547285 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 5,182E-03 0,03536758 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! detection of mechanical stimulus GO:0050982 15 11 1,000 5,222E-03 0,03553247 ! membrane protein proteolysis GO:0033619 18 11 1,000 5,222E-03 0,03542765 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 5,222E-03 0,03532345 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 5,222E-03 0,03521986 ! histone deacetylation GO:0016575 13 11 1,000 5,222E-03 0,03511688 ! chromatin silencing GO:0006342 19 11 1,000 5,222E-03 0,0350145 ! T cell homeostasis GO:0043029 20 11 1,000 5,222E-03 0,03491271 ! regulation of isotype switching GO:0045191 19 11 1,000 5,222E-03 0,03481152 ! digestive tract morphogenesis GO:0048546 15 11 1,000 5,222E-03 0,03471091 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! germ cell migration GO:0008354 18 11 1,000 5,222E-03 0,03461088 ! response to reactive oxygen species GO:0000302 55 36 2,000 5,612E-03 0,03709004 ! negative regulation of binding GO:0051100 58 36 2,000 5,612E-03 0,03698377 ! tissue remodeling GO:0048771 62 36 2,000 5,612E-03 0,0368781 ! steroid biosynthetic process GO:0006694 94 71 3,000 5,711E-03 0,03742249 ! lymphocyte differentiation GO:0030098 113 71 3,000 5,711E-03 0,03731618 ! negative regulation of organelle organization GO:0010639 115 72 3,000 6E-03 0,03909547 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 6,225E-03 0,04044354 ! cartilage condensation GO:0001502 18 12 1,000 6,225E-03 0,04032962 ! heart looping GO:0001947 15 12 1,000 6,225E-03 0,04021633 ! positive regulation of cell growth GO:0030307 16 12 1,000 6,225E-03 0,04010368 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 1,000 6,225E-03 0,03999166 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 6,225E-03 0,03988026 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 6,225E-03 0,03976949 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 6,225E-03 0,03965932 ! histone methylation GO:0016571 15 12 1,000 6,225E-03 0,03954976 ! autonomic nervous system development GO:0048483 23 12 1,000 6,225E-03 0,03944081 ! gland morphogenesis GO:0022612 23 12 1,000 6,225E-03 0,03933246 ! peptidyl-lysine modification GO:0018205 18 12 1,000 6,225E-03 0,0392247 ! response to gamma radiation GO:0010332 20 12 1,000 6,225E-03 0,03911753 ! regulation of mRNA stability GO:0043488 27 12 1,000 6,225E-03 0,03901094 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 6,225E-03 0,03890493 ! mitochondrion organization GO:0007005 104 73 3,000 6,299E-03 0,03926335 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 6,608E-03 0,04107576 ! negative regulation of protein complex disassembly GO:0043242 67 39 2,000 7,027E-03 0,04356229 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 7,027E-03 0,04344518 ! chromatin remodeling GO:0006338 68 39 2,000 7,027E-03 0,04332871 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 7,255E-03 0,04461523 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 7,308E-03 0,04482325 ! regulation of chemokine production GO:0032642 17 13 1,000 7,308E-03 0,04470404 ! regulation of cell-cell adhesion GO:0022407 27 13 1,000 7,308E-03 0,04458546 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 7,308E-03 0,04446751 ! regulation of DNA repair GO:0006282 15 13 1,000 7,308E-03 0,04435018 ! regulation of RNA stability GO:0043487 28 13 1,000 7,308E-03 0,04423347 ! lymphocyte homeostasis GO:0002260 24 13 1,000 7,308E-03 0,04411737 ! inner ear development GO:0048839 57 40 2,000 7,541E-03 0,04540446 ! T cell differentiation GO:0030217 65 40 2,000 7,541E-03 0,04528591 ! B cell differentiation GO:0030183 62 40 2,000 7,541E-03 0,04516798 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 7,541E-03 0,04505066 ! one-carbon metabolic process GO:0006730 110 77 3,000 7,593E-03 0,04524584 ! biopolymer methylation GO:0043414 62 41 2,000 8,077E-03 0,04800337 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 8,47E-03 0,05020923 ! regulation of S phase GO:0033261 18 14 1,000 8,47E-03 0,05008015 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 8,47E-03 0,04995174 ! startle response GO:0001964 21 14 1,000 8,47E-03 0,04982399 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 1,000 8,47E-03 0,04969689 ! epidermis morphogenesis GO:0048730 29 14 1,000 8,47E-03 0,04957043 ! cellular response to starvation GO:0009267 21 14 1,000 8,47E-03 0,04944462 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 8,47E-03 0,04931944 GO:0060675|ureteric bud morphogenesis, ! muscle maintenance GO:0046716 19 14 1,000 8,47E-03 0,0491949 ! cellular component disassembly GO:0022411 64 42 2,000 8,635E-03 0,05002638 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 8,635E-03 0,04990068 ! regulation of gene expression, epigenetic GO:0040029 72 42 2,000 8,635E-03 0,04977562 ! leukocyte migration GO:0050900 60 43 2,000 9,215E-03 0,05298608 ! activation of caspase activity GO:0006919 65 43 2,000 9,215E-03 0,05285394 ! response to insulin stimulus GO:0032868 63 43 2,000 9,215E-03 0,05272246 ! methylation GO:0032259 64 43 2,000 9,215E-03 0,05259164 ! ossification GO:0001503 134 82 3,000 9,443E-03 0,05375728 GO:0060348|bone development, ! positive regulation of cell size GO:0045793 20 15 1,000 9,709E-03 0,05513715 ! metencephalon development GO:0022037 19 15 1,000 9,709E-03 0,05500135 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 9,709E-03 0,05486621 ! lipid phosphorylation GO:0046834 23 15 1,000 9,709E-03 0,05473173 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 1,000 9,709E-03 0,05459791 ! regulation of survival gene product expression GO:0045884 20 15 1,000 9,709E-03 0,05446475 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 9,709E-03 0,05433223 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 9,709E-03 0,05420035 ! regulation of T-helper cell differentiation GO:0045622 23 15 1,000 9,709E-03 0,05406912 ! glycolysis GO:0006096 53 44 2,000 9,817E-03 0,05454006 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 9,817E-03 0,05440863 ! regulation of inflammatory response GO:0050727 60 44 2,000 9,817E-03 0,05427784 ! positive regulation of cell cycle GO:0045787 77 45 2,000 0,01044187 0,05759304 ! positive regulation of defense response GO:0031349 59 45 2,000 0,01044187 0,05745526 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 0,01044187 0,05731814 ! anterior/posterior pattern formation GO:0009952 124 85 3,000 0,01068118 0,05849218 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 0,01102305 0,06022097 ! protein amino acid deacetylation GO:0006476 20 16 1,000 0,01102305 0,06007826 ! protein amino acid acetylation GO:0006473 28 16 1,000 0,01102305 0,05993623 ! patterning of blood vessels GO:0001569 24 16 1,000 0,01102305 0,05979487 ! protein polyubiquitination GO:0000209 26 16 1,000 0,01102305 0,05965418 ! negative regulation of immune response GO:0050777 28 16 1,000 0,01102305 0,05951415 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 1,000 0,01102305 0,05937477 ! oogenesis GO:0048477 23 16 1,000 0,01102305 0,05923604 ! neural crest cell migration GO:0001755 24 16 1,000 0,01102305 0,05909796 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 0,01102305 0,05896053 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 0,01102305 0,05882373 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 1,000 0,01102305 0,05868756 ! nerve development GO:0021675 18 16 1,000 0,01102305 0,05855202 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 0,01102305 0,05841711 ! negative regulation of translation GO:0017148 22 16 1,000 0,01102305 0,05828282 ! regulation of protein complex disassembly GO:0043244 77 46 2,000 0,0110891 0,05849753 ! cell cycle arrest GO:0007050 150 86 3,000 0,01111623 0,05850648 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 0,01156255 0,06071659 ! positive regulation of cell killing GO:0031343 24 17 1,000 0,01241082 0,06502252 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 0,01241082 0,06487474 ! regulation of viral genome replication GO:0045069 24 17 1,000 0,01241082 0,06472764 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 0,01241082 0,06458119 ! actin filament bundle formation GO:0051017 26 17 1,000 0,01241082 0,06443541 ! neuromuscular junction development GO:0007528 23 17 1,000 0,01241082 0,06429029 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 0,01241082 0,06414581 GO:0002712|regulation of B cell mediated immunity, ! regulation of immunoglobulin production GO:0002637 25 17 1,000 0,01241082 0,06400199 ! positive regulation of caspase activity GO:0043280 72 48 2,000 0,01245179 0,06406963 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 0,01245179 0,06392662 ! regulation of DNA replication GO:0006275 75 48 2,000 0,01245179 0,06378424 ! protein modification by small protein conjugation GO:0032446 140 90 3,000 0,01297011 0,0662917 ! hormone metabolic process GO:0042445 121 90 3,000 0,01297011 0,06614471 ! regulation of angiogenesis GO:0045765 94 49 2,000 0,01316751 0,06700279 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 0,01316751 0,06685488 ! germ cell development GO:0007281 68 49 2,000 0,01316751 0,06670763 ! response to virus GO:0009615 122 91 3,000 0,01346249 0,06805216 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 0,01387063 0,06996152 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 0,01387063 0,06980843 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 1,000 0,01387063 0,06965601 ! central nervous system neuron development GO:0021954 30 18 1,000 0,01387063 0,06950425 ! synaptic vesicle transport GO:0048489 33 18 1,000 0,01387063 0,06935316 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 0,01387063 0,06920272 ! cellular response to nutrient levels GO:0031669 27 18 1,000 0,01387063 0,06905293 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,01387063 0,06890378 ! gut development GO:0048565 26 18 1,000 0,01387063 0,06875529 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01387063 0,06860742 ! negative regulation of cytoskeleton organization GO:0051494 84 50 2,000 0,01390627 0,06863609 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,01390627 0,06848912 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 0,01396662 0,06863938 ! response to oxidative stress GO:0006979 141 94 3,000 0,01501048 0,07361218 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01540091 0,07536617 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 0,01540091 0,07520616 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 0,01540091 0,07504682 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,01540091 0,07488816 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 0,01540091 0,07473017 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01540091 0,07457284 ! response to starvation GO:0042594 30 19 1,000 0,01540091 0,07441618 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01540091 0,07426017 ! renal system process GO:0003014 35 19 1,000 0,01540091 0,07410481 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 0,01540091 0,07395011 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 0,01540091 0,07379604 ! protein stabilization GO:0050821 26 19 1,000 0,01540091 0,07364262 ! aging GO:0007568 79 52 2,000 0,01545331 0,07373986 ! protein modification by small protein conjugation or removal GO:0070647 148 96 3,000 0,01610238 0,07667799 ! response to light stimulus GO:0009416 153 96 3,000 0,01610238 0,07651956 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01626175 0,07711756 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 0,01666654 0,07887457 ! response to ethanol GO:0045471 37 20 1,000 0,01700012 0,08028802 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01700012 0,0801235 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01700012 0,07995965 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 0,01700012 0,07979646 ! fatty acid beta-oxidation GO:0006635 31 20 1,000 0,01700012 0,07963395 ! DNA modification GO:0006304 28 20 1,000 0,01700012 0,07947209 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 0,01700012 0,07931089 ! actin filament-based movement GO:0030048 34 20 1,000 0,01700012 0,07915034 ! glucose catabolic process GO:0006007 66 54 2,000 0,01709355 0,07942456 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01709355 0,07926443 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01866671 0,08638519 ! regulation of cell killing GO:0031341 34 21 1,000 0,01866671 0,08621173 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 0,01866671 0,08603896 ! gluconeogenesis GO:0006094 25 21 1,000 0,01866671 0,08586688 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01866671 0,08569549 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01866671 0,08552478 ! ovarian follicle development GO:0001541 30 21 1,000 0,01866671 0,08535475 ! autophagy GO:0006914 28 21 1,000 0,01866671 0,0851854 ! cell aging GO:0007569 32 21 1,000 0,01866671 0,08501672 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01866671 0,0848487 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 0,01866671 0,08468134 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01866671 0,08451465 ! immunoglobulin production GO:0002377 33 21 1,000 0,01866671 0,08434861 GO:0002440|production of molecular mediator of immune response, ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 0,01866671 0,08418322 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01866671 0,08401848 ! multicellular organism reproduction GO:0032504 83 57 2,000 0,01972962 0,08862917 GO:0048609|reproductive process in a multicellular organism, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,0203992 0,09145842 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,0203992 0,09128048 ! leukocyte adhesion GO:0007159 38 22 1,000 0,0203992 0,09110324 ! molting cycle process GO:0022404 40 22 1,000 0,0203992 0,09092668 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,0203992 0,09075081 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,0203992 0,09057561 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 0,0203992 0,09040109 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! ureteric bud development GO:0001657 32 22 1,000 0,0203992 0,09022724 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,0203992 0,09005406 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 0,02065532 0,09101005 ! actin filament organization GO:0007015 95 59 2,000 0,02160457 0,09501052 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,0221961 0,09742565 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,0221961 0,09724008 ! myelination GO:0042552 35 23 1,000 0,0221961 0,09705521 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,0221961 0,09687104 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,0221961 0,09668758 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,0221961 0,0965048 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,0221961 0,09632272 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,0221961 0,09614132 ! regulation of heart contraction GO:0008016 91 60 2,000 0,02257736 0,09760889 ! meiosis GO:0007126 96 61 2,000 0,02357371 0,10172518 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 2,000 0,02357371 0,10153468 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,02405596 0,10341815 ! initiation of viral infection GO:0019059 42 24 1,000 0,02405596 0,1032252 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,02405596 0,10303298 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,02405596 0,10284147 ! neural crest cell development GO:0014032 39 24 1,000 0,02405596 0,10265067 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,02405596 0,10246057 ! negative regulation of cell development GO:0010721 56 24 1,000 0,02405596 0,10227118 GO:0050768|negative regulation of neurogenesis, ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,02405596 0,10208249 GO:0002708|positive regulation of lymphocyte mediated immunity, ! meiotic cell cycle GO:0051321 97 62 2,000 0,02459359 0,10417176 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,02563701 0,10839179 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,02563701 0,10819291 ! protein amino acid alkylation GO:0008213 39 25 1,000 0,02597734 0,10942834 GO:0006479|protein amino acid methylation, ! male gonad development GO:0008584 33 25 1,000 0,02597734 0,10922829 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,02597734 0,10902897 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,02597734 0,10883037 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,02597734 0,1086325 ! hexose catabolic process GO:0019320 82 64 2,000 0,02670394 0,11146836 ! reproductive structure development GO:0048608 90 65 2,000 0,02779435 0,11580978 ! regulation of caspase activity GO:0043281 97 65 2,000 0,02779435 0,11560036 ! B cell activation GO:0042113 104 65 2,000 0,02779435 0,1153917 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,02795882 0,11586539 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,02795882 0,115657 ! post-embryonic development GO:0009791 42 26 1,000 0,02795882 0,11544936 ! axon guidance GO:0007411 99 66 2,000 0,02890819 0,11915564 ! response to ionizing radiation GO:0010212 47 27 1,000 0,02999903 0,1234307 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,02999903 0,12321028 ! lipid oxidation GO:0034440 38 27 1,000 0,02999903 0,12299066 GO:0019395|fatty acid oxidation, ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,02999903 0,12277181 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02999903 0,12255375 ! gene silencing GO:0016458 41 27 1,000 0,02999903 0,12233645 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 2,000 0,03004544 0,12230887 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,03004544 0,12209278 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,03004544 0,12187745 ! cytosolic calcium ion homeostasis GO:0051480 107 68 2,000 0,03120603 0,12636245 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,03209658 0,12974012 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,03209658 0,12951251 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 1,000 0,03209658 0,12928569 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,03209658 0,12905967 ! mesoderm formation GO:0001707 46 28 1,000 0,03209658 0,12883443 ! ensheathment of neurons GO:0007272 43 28 1,000 0,03209658 0,12860998 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,03209658 0,12838631 ! response to drug GO:0042493 108 69 2,000 0,03238991 0,12933473 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,03425013 0,13652566 ! ovulation cycle process GO:0022602 41 29 1,000 0,03425013 0,13628946 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,03425013 0,13605407 ! formation of primary germ layer GO:0001704 48 29 1,000 0,03425013 0,13581949 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,03425013 0,13558573 ! tissue homeostasis GO:0001894 42 29 1,000 0,03425013 0,13535276 GO:0048871|multicellular organismal homeostasis, ! monosaccharide catabolic process GO:0046365 91 71 2,000 0,03482729 0,13739754 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,03608064 0,14209839 ! collagen metabolic process GO:0032963 40 30 1,000 0,03645836 0,14334057 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,03645836 0,14309597 ! spindle organization GO:0007051 37 30 1,000 0,03645836 0,14285219 ! ovulation cycle GO:0042698 43 30 1,000 0,03645836 0,14260925 ! fatty acid catabolic process GO:0009062 43 30 1,000 0,03645836 0,14236712 ! adult locomotory behavior GO:0008344 47 30 1,000 0,03645836 0,14212582 ! response to heat GO:0009408 41 30 1,000 0,03645836 0,14188534 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,03645836 0,14164567 ! negative regulation of transport GO:0051051 116 73 2,000 0,03735698 0,14489218 ! tube morphogenesis GO:0035239 118 73 2,000 0,03735698 0,14464825 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,03865624 0,14942749 ! odontogenesis GO:0042476 50 31 1,000 0,03871996 0,14942268 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,03871996 0,14917239 ! metanephros development GO:0001656 58 31 1,000 0,03871996 0,14892294 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03871996 0,14867432 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03871996 0,14842653 ! cell fate specification GO:0001708 37 31 1,000 0,03871996 0,14817956 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,04103365 0,15677308 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,04103365 0,15651309 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,04103365 0,15625396 ! meiosis I GO:0007127 52 32 1,000 0,04103365 0,15599569 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,04103365 0,15573828 ! peripheral nervous system development GO:0007422 53 32 1,000 0,04103365 0,1554817 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,04103365 0,15522598 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,04103365 0,15497109 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,04103365 0,15471704 ! regulation of DNA binding GO:0051101 119 77 2,000 0,04269054 0,1607009 ! sex differentiation GO:0007548 105 77 2,000 0,04269054 0,16043831 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,04339816 0,16283158 ! sister chromatid segregation GO:0000819 46 33 1,000 0,04339816 0,16256638 ! ear morphogenesis GO:0042471 42 33 1,000 0,04339816 0,16230205 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,04339816 0,16203857 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,04339816 0,16177595 ! female gonad development GO:0008585 49 33 1,000 0,04339816 0,16151417 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,04339816 0,16125324 ! positive regulation of cell development GO:0010720 54 33 1,000 0,04339816 0,16099316 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,04581224 0,16967495 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,04581224 0,16940216 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,04581224 0,16913025 ! female gamete generation GO:0007292 43 34 1,000 0,04581224 0,16885921 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,04581224 0,16858903 ! embryonic organ development GO:0048568 45 34 1,000 0,04581224 0,16831972 ! alcohol catabolic process GO:0046164 104 80 2,000 0,04692741 0,17214201 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,04827467 0,17680213 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,04827467 0,17652105 ! glycogen metabolic process GO:0005977 48 35 1,000 0,04827467 0,17624085 ! pigment metabolic process GO:0042440 61 35 1,000 0,04827467 0,17596155 ! regulation of neurological system process GO:0031644 122 81 2,000 0,04838417 0,17608164 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,04838417 0,17580347 GO:0002696|positive regulation of leukocyte activation, ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04933963 0,17899234 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04933963 0,17871047 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04933963 0,17842947 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04933963 0,17814937 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04933963 0,17787013 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04933963 0,17759178 ! sleep GO:0030431 11 5 0,000 0,04933963 0,17731429 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04933963 0,17703767 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04933963 0,17676191 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04933963 0,17648701 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04933963 0,17621296 ! tongue development GO:0043586 6 5 0,000 0,04933963 0,17593976 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04933963 0,17566741 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04933963 0,1753959 ! cobalt ion transport GO:0006824 9 5 0,000 0,04933963 0,17512523 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04933963 0,17485539 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04933963 0,17458638 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04933963 0,1743182 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04933963 0,17405084 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04933963 0,1737843 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04933963 0,17351857 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04933963 0,17325366 GO:0048596|embryonic camera-type eye morphogenesis, ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04933963 0,17298955 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04933963 0,17272625 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04933963 0,17246375 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04933963 0,17220204 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04933963 0,17194113 ! malate metabolic process GO:0006108 7 5 0,000 0,04933963 0,17168101 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04933963 0,17142167 ! behavioral response to pain GO:0048266 7 5 0,000 0,04933963 0,17116312 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04933963 0,17090534 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04933963 0,17064834 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04933963 0,17039211 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04933963 0,17013665 ! mating behavior GO:0007617 6 5 0,000 0,04933963 0,16988196 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04933963 0,16962802 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04933963 0,16937484 ! rhythmic behavior GO:0007622 12 5 0,000 0,04933963 0,16912242 ! copulation GO:0007620 7 5 0,000 0,04933963 0,16887075 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04933963 0,16861983 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04933963 0,16836965 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04933963 0,16812022 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04933963 0,16787152 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04933963 0,16762355 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04933963 0,16737632 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04933963 0,16712982 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04933963 0,16688404 ! response to protozoan GO:0001562 9 5 0,000 0,04933963 0,16663898 ! lymph vessel development GO:0001945 7 5 0,000 0,04933963 0,16639464 ! endochondral ossification GO:0001958 12 5 0,000 0,04933963 0,16615102 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04933963 0,16590811 ! parathyroid gland development GO:0060017 8 5 0,000 0,04933963 0,16566591 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04933963 0,16542441 ! anagen GO:0042640 6 5 0,000 0,04933963 0,16518362 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04933963 0,16494353 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04933963 0,16470413 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04933963 0,16446543 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04933963 0,16422742 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04933963 0,1639901 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04933963 0,16375346 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04933963 0,1635175 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04933963 0,16328222 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04933963 0,16304762 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04933963 0,1628137 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04933963 0,16258044 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04933963 0,16234785 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04933963 0,16211592 ! ovulation GO:0030728 6 5 0,000 0,04933963 0,16188466 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04933963 0,16165405 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,04933963 0,16142411 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,04933963 0,16119481 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04933963 0,16096616 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04933963 0,16073817 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04933963 0,16051081 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04933963 0,1602841 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04933963 0,16005803 ! polyol catabolic process GO:0046174 7 5 0,000 0,04933963 0,1598326 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04933963 0,1596078 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04933963 0,15938363 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04933963 0,15916009 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04933963 0,15893718 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04933963 0,15871489 ! urea metabolic process GO:0019627 6 5 0,000 0,04933963 0,15849322 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04933963 0,15827217 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04933963 0,15805174 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04933963 0,15783191 ! neutrophil activation GO:0042119 5 5 0,000 0,04933963 0,1576127 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04933963 0,1573941 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04933963 0,1571761 ! response to food GO:0032094 5 5 0,000 0,04933963 0,15695871 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04933963 0,15674191 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04933963 0,15652572 ! forebrain neuron development GO:0021884 7 5 0,000 0,04933963 0,15631012 ! melanosome organization GO:0032438 7 5 0,000 0,04933963 0,15609511 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04933963 0,1558807 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04933963 0,15566687 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04933963 0,15545362 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04933963 0,15524097 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04933963 0,15502889 ! nucleoside transport GO:0015858 6 5 0,000 0,04933963 0,15481739 ! nucleoside salvage GO:0043174 7 5 0,000 0,04933963 0,15460647 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04933963 0,15439612 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04933963 0,15418634 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04933963 0,15397713 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04933963 0,15376849 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04933963 0,15356041 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04933963 0,1533529 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04933963 0,15314595 ! depyrimidination GO:0045008 8 5 0,000 0,04933963 0,15293955 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04933963 0,15273371 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04933963 0,15252842 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04933963 0,15232369 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04933963 0,1521195 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04933963 0,15191586 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04933963 0,15171276 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04933963 0,15151021 ! monocyte differentiation GO:0030224 8 5 0,000 0,04933963 0,15130819 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04933963 0,15110672 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04933963 0,15090578 ! centrosome duplication GO:0051298 5 5 0,000 0,04933963 0,15070537 ! response to UV-C GO:0010225 6 5 0,000 0,04933963 0,1505055 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04933963 0,15030615 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04933963 0,15010734 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04933963 0,14990904 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04933963 0,14971127 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04933963 0,14951403 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04933963 0,1493173 ! melanosome transport GO:0032402 8 5 0,000 0,04933963 0,14912109 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04933963 0,14892539 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04933963 0,1487302 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04933963 0,14853553 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04933963 0,14834137 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04933963 0,14814771 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04933963 0,14795456 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04933963 0,14776191 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04933963 0,14756976 ! neural tube patterning GO:0021532 6 5 0,000 0,04933963 0,14737811 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04933963 0,14718696 ! histone demethylation GO:0016577 9 5 0,000 0,04933963 0,1469963 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04933963 0,14680614 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04933963 0,14661647 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,04933963 0,14642729 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04933963 0,14623859 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04933963 0,14605038 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04933963 0,14586266 ! transcription termination GO:0006353 8 5 0,000 0,04933963 0,14567541 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04933963 0,14548865 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04933963 0,14530236 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04933963 0,14511656 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04933963 0,14493122 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04933963 0,14474636 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04933963 0,14456197 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04933963 0,14437805 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04933963 0,14419459 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04933963 0,14401161 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04933963 0,14382908 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04933963 0,14364702 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04933963 0,14346542 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04933963 0,14328428 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04933963 0,14310359 ! glial cell migration GO:0008347 10 5 0,000 0,04933963 0,14292336 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04933963 0,14274358 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04933963 0,14256425 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04933963 0,14238538 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04933963 0,14220695 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04933963 0,14202897 ! neural plate development GO:0001840 6 5 0,000 0,04933963 0,14185143 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04933963 0,14167434 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04933963 0,14149769 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04933963 0,14132148 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04933963 0,1411457 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04933963 0,14097037 ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04933963 0,14079547 ! spindle assembly GO:0051225 5 5 0,000 0,04933963 0,140621 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04933963 0,14044696 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04933963 0,14027336 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04933963 0,14010018 ! organ regeneration GO:0031100 7 5 0,000 0,04933963 0,13992743 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04933963 0,13975511 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04933963 0,13958321 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04933963 0,13941173 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04933963 0,13924067 GO:0055081|anion homeostasis, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,05078424 0,14314186 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,05078424 0,14296666 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,05078424 0,14279188 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,05078424 0,14261754 GO:0006073|cellular glucan metabolic process, ! regulation of defense response GO:0031347 117 84 2,000 0,05288612 0,14833911 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,05288612 0,14815843 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,05333978 0,14924755 ! learning GO:0007612 67 37 1,000 0,05333978 0,14906621 ! regulation of protein localization GO:0032880 132 85 2,000 0,0544302 0,15192896 ! regulation of membrane potential GO:0042391 128 85 2,000 0,0544302 0,1517448 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,0544302 0,15156109 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,0559401 0,15557706 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,05758267 0,15995185 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 2,000 0,05758267 0,15975891 ! male sex differentiation GO:0046661 53 39 1,000 0,05858406 0,16234138 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,05858406 0,16214602 ! developmental growth GO:0048589 62 39 1,000 0,05858406 0,16195113 ! synapse organization GO:0050808 55 39 1,000 0,05858406 0,16175672 ! tRNA transcription GO:0009304 11 6 0,000 0,05891314 0,16247029 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05891314 0,16227571 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05891314 0,1620816 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05891314 0,16188795 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05891314 0,16169477 ! regulation of helicase activity GO:0051095 11 6 0,000 0,05891314 0,16150205 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05891314 0,16130978 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05891314 0,16111798 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05891314 0,16092662 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05891314 0,16073573 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05891314 0,16054528 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05891314 0,16035529 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05891314 0,16016574 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05891314 0,15997664 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05891314 0,15978799 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05891314 0,15959979 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05891314 0,15941202 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05891314 0,1592247 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05891314 0,15903781 ! neuron adhesion GO:0007158 9 6 0,000 0,05891314 0,15885137 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05891314 0,15866536 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05891314 0,15847979 ! signal peptide processing GO:0006465 8 6 0,000 0,05891314 0,15829465 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05891314 0,15810994 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05891314 0,15792566 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05891314 0,15774181 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05891314 0,15755839 ! opsonization GO:0008228 8 6 0,000 0,05891314 0,1573754 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05891314 0,15719283 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05891314 0,15701068 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05891314 0,15682896 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05891314 0,15664765 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05891314 0,15646676 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05891314 0,1562863 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05891314 0,15610624 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05891314 0,1559266 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05891314 0,15574738 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05891314 0,15556856 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05891314 0,15539016 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05891314 0,15521216 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05891314 0,15503457 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05891314 0,15485739 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05891314 0,15468061 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05891314 0,15450424 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05891314 0,15432827 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05891314 0,15415269 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05891314 0,15397752 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05891314 0,15380274 ! protein lipoylation GO:0009249 10 6 0,000 0,05891314 0,15362836 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05891314 0,15345438 ! drug transport GO:0015893 6 6 0,000 0,05891314 0,15328079 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05891314 0,15310759 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,05891314 0,15293478 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05891314 0,15276237 ! histidine metabolic process GO:0006547 6 6 0,000 0,05891314 0,15259034 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05891314 0,15241869 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05891314 0,15224744 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05891314 0,15207656 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05891314 0,15190607 ! adenohypophysis development GO:0021984 10 6 0,000 0,05891314 0,15173597 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05891314 0,15156624 ! hyperosmotic response GO:0006972 8 6 0,000 0,05891314 0,15139689 ! microtubule nucleation GO:0007020 10 6 0,000 0,05891314 0,15122792 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05891314 0,15105933 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05891314 0,15089111 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05891314 0,15072327 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05891314 0,1505558 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05891314 0,1503887 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05891314 0,15022197 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05891314 0,15005561 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05891314 0,14988962 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05891314 0,149724 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05891314 0,14955874 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05891314 0,14939385 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05891314 0,14922931 ! neuron apoptosis GO:0051402 8 6 0,000 0,05891314 0,14906515 ! organic alcohol transport GO:0015850 9 6 0,000 0,05891314 0,14890134 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05891314 0,14873789 ! male sex determination GO:0030238 9 6 0,000 0,05891314 0,1485748 ! carnitine transport GO:0015879 8 6 0,000 0,05891314 0,14841207 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05891314 0,14824969 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05891314 0,14808767 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05891314 0,147926 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05891314 0,14776469 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05891314 0,14760372 ! parturition GO:0007567 12 6 0,000 0,05891314 0,14744311 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05891314 0,14728285 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05891314 0,14712293 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05891314 0,14696336 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05891314 0,14680414 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05891314 0,14664526 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05891314 0,14648672 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,05891314 0,14632853 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05891314 0,14617068 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05891314 0,14601317 ! macrophage differentiation GO:0030225 10 6 0,000 0,05891314 0,14585599 ! astrocyte development GO:0014002 14 6 0,000 0,05891314 0,14569916 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05891314 0,14554266 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05891314 0,1453865 ! interaction with symbiont GO:0051702 8 6 0,000 0,05891314 0,14523067 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05891314 0,14507518 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05891314 0,14492002 ! eating behavior GO:0042755 6 6 0,000 0,05891314 0,14476519 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05891314 0,14461069 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05891314 0,14445652 ! response to copper ion GO:0046688 9 6 0,000 0,05891314 0,14430268 ! DNA topological change GO:0006265 8 6 0,000 0,05891314 0,14414917 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05891314 0,14399598 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,05891314 0,14384312 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05891314 0,14369058 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05891314 0,14353837 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05891314 0,14338647 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05891314 0,1432349 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05891314 0,14308365 ! hair follicle maturation GO:0048820 7 6 0,000 0,05891314 0,14293272 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05891314 0,14278211 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05891314 0,14263181 ! Schwann cell development GO:0014044 14 6 0,000 0,05891314 0,14248183 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05891314 0,14233216 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05891314 0,14218281 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05891314 0,14203377 ! histone ubiquitination GO:0016574 7 6 0,000 0,05891314 0,14188504 ! regulation of meiosis GO:0040020 10 6 0,000 0,05891314 0,14173663 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05891314 0,14158852 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05891314 0,14144073 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05891314 0,14129324 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05891314 0,14114606 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05891314 0,14099919 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05891314 0,14085262 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05891314 0,14070635 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05891314 0,14056039 ! receptor internalization GO:0031623 9 6 0,000 0,05891314 0,14041473 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05891314 0,14026938 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05891314 0,14012432 ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05891314 0,13997956 ! protein deubiquitination GO:0016579 8 6 0,000 0,05891314 0,13983511 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05891314 0,13969095 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,05891314 0,13954708 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05891314 0,13940352 ! axonal fasciculation GO:0007413 9 6 0,000 0,05891314 0,13926024 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05891314 0,13911727 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05891314 0,13897458 ! midbrain development GO:0030901 6 6 0,000 0,05891314 0,13883219 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05891314 0,13869009 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05891314 0,13854828 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05891314 0,13840676 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05891314 0,13826553 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05891314 0,13812459 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05891314 0,13798393 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05891314 0,13784356 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05891314 0,13770347 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05891314 0,13756367 ! adult feeding behavior GO:0008343 6 6 0,000 0,05891314 0,13742416 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05891314 0,13728492 ! blastocyst growth GO:0001832 15 6 0,000 0,05891314 0,13714597 ! pigment granule transport GO:0051904 12 6 0,000 0,05891314 0,1370073 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05891314 0,13686891 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05891314 0,1367308 ! catecholamine transport GO:0051937 7 6 0,000 0,05891314 0,13659296 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05891314 0,13645541 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05891314 0,13631813 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05891314 0,13618112 ! protein prenylation GO:0018342 10 6 0,000 0,05891314 0,1360444 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05891314 0,13590794 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05891314 0,13577176 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05891314 0,13563585 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05891314 0,13550022 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,05919075 0,13600273 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,06081987 0,13960649 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,06127053 0,14050073 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,06127053 0,14036079 ! double-strand break repair GO:0006302 67 40 1,000 0,06127053 0,14022112 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,06127053 0,14008174 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,0639984 0,14617312 ! glucose transport GO:0015758 52 41 1,000 0,0639984 0,1460281 ! endosome transport GO:0016197 71 41 1,000 0,0639984 0,14588338 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,0639984 0,14573894 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,0639984 0,14559479 ! cell fate commitment GO:0045165 141 92 2,000 0,06583182 0,14961778 ! mitochondrial transport GO:0006839 60 42 1,000 0,06676657 0,15159242 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,06676657 0,15144292 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,06676657 0,15129372 ! hexose transport GO:0008645 54 42 1,000 0,06676657 0,1511448 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 1,000 0,06676657 0,15099619 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,06676657 0,15084786 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,06754347 0,15245336 ! carbohydrate catabolic process GO:0016052 121 93 2,000 0,06754347 0,15230389 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06839078 0,15406346 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06839078 0,15391272 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06839078 0,15376226 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06839078 0,15361211 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06839078 0,15346224 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06839078 0,15331267 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06839078 0,15316339 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06839078 0,15301439 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06839078 0,15286569 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06839078 0,15271728 ! reproductive behavior GO:0019098 12 7 0,000 0,06839078 0,15256915 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06839078 0,15242131 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,06839078 0,15227376 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06839078 0,1521265 ! oligopeptide transport GO:0006857 11 7 0,000 0,06839078 0,15197951 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06839078 0,15183282 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06839078 0,1516864 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06839078 0,15154027 ! RNA methylation GO:0001510 11 7 0,000 0,06839078 0,15139441 ! pericardium development GO:0060039 8 7 0,000 0,06839078 0,15124884 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06839078 0,15110355 ! fibril organization GO:0043206 13 7 0,000 0,06839078 0,15095854 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06839078 0,1508138 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06839078 0,15066935 ! lipoprotein transport GO:0042953 9 7 0,000 0,06839078 0,15052516 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06839078 0,15038126 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06839078 0,15023763 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06839078 0,15009427 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06839078 0,14995119 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06839078 0,14980838 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06839078 0,14966584 ! chemosensory behavior GO:0007635 9 7 0,000 0,06839078 0,14952357 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06839078 0,14938157 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06839078 0,14923984 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06839078 0,14909839 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06839078 0,14895719 ! reflex GO:0060004 12 7 0,000 0,06839078 0,14881627 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06839078 0,14867561 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06839078 0,14853522 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06839078 0,14839509 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06839078 0,14825523 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06839078 0,14811563 ! spinal cord patterning GO:0021511 7 7 0,000 0,06839078 0,14797629 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06839078 0,14783721 ! adrenal gland development GO:0030325 17 7 0,000 0,06839078 0,1476984 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06839078 0,14755985 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06839078 0,14742155 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06839078 0,14728352 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06839078 0,14714574 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06839078 0,14700822 ! endosome organization GO:0007032 10 7 0,000 0,06839078 0,14687096 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06839078 0,14673395 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06839078 0,1465972 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06839078 0,1464607 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06839078 0,14632446 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06839078 0,14618847 ! galactose metabolic process GO:0006012 10 7 0,000 0,06839078 0,14605274 ! vesicle fusion GO:0006906 15 7 0,000 0,06839078 0,14591725 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06839078 0,14578202 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06839078 0,14564703 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06839078 0,1455123 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06839078 0,14537782 ! retinol metabolic process GO:0042572 9 7 0,000 0,06839078 0,14524358 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06839078 0,14510959 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06839078 0,14497585 ! rRNA modification GO:0000154 12 7 0,000 0,06839078 0,14484235 ! protein heterooligomerization GO:0051291 10 7 0,000 0,06839078 0,1447091 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06839078 0,1445761 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,06839078 0,14444334 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06839078 0,14431082 ! intermediate filament organization GO:0045109 11 7 0,000 0,06839078 0,14417855 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06839078 0,14404652 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06839078 0,14391473 ! fibrinolysis GO:0042730 9 7 0,000 0,06839078 0,14378318 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06839078 0,14365187 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06839078 0,1435208 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06839078 0,14338997 ! response to tropane GO:0014073 13 7 0,000 0,06839078 0,14325938 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06839078 0,14312902 ! melanosome localization GO:0032400 10 7 0,000 0,06839078 0,14299891 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06839078 0,14286903 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06839078 0,14273938 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06839078 0,14260997 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06839078 0,14248079 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06839078 0,14235185 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06839078 0,14222314 ! mast cell activation GO:0045576 9 7 0,000 0,06839078 0,14209467 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06839078 0,14196642 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06839078 0,14183841 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06839078 0,14171063 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06839078 0,14158308 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06839078 0,14145575 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06839078 0,14132866 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06839078 0,14120179 ! response to tumor cell GO:0002347 12 7 0,000 0,06839078 0,14107515 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06839078 0,14094874 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06839078 0,14082256 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06839078 0,1406966 ! diuresis GO:0030146 12 7 0,000 0,06839078 0,14057086 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06839078 0,14044535 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06839078 0,14032007 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06839078 0,14019501 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06839078 0,14007017 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06839078 0,13994555 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06839078 0,13982115 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06839078 0,13969698 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06839078 0,13957302 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06839078 0,13944929 ! lymph node development GO:0048535 9 7 0,000 0,06839078 0,13932577 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06839078 0,13920247 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06839078 0,1390794 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06839078 0,13895653 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06839078 0,13883389 ! ATP catabolic process GO:0006200 10 7 0,000 0,06839078 0,13871146 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06839078 0,13858925 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06839078 0,13846725 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06839078 0,13834547 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06839078 0,1382239 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06839078 0,13810254 ! muscle adaptation GO:0043500 12 7 0,000 0,06839078 0,1379814 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06839078 0,13786047 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06839078 0,13773975 ! retina homeostasis GO:0001895 9 7 0,000 0,06839078 0,13761924 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06839078 0,13749895 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06839078 0,13737886 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06839078 0,13725898 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06839078 0,13713932 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06839078 0,13701986 ! positive regulation of binding GO:0051099 59 43 1,000 0,06957397 0,13926904 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,06957397 0,13914794 ! neuromuscular process GO:0050905 79 43 1,000 0,06957397 0,13902705 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,06957397 0,13890636 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,06957397 0,13878589 ! regulation of action potential GO:0001508 71 44 1,000 0,07241953 0,14433702 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,07241953 0,14421205 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,07279899 0,14484228 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,07530221 0,14969325 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,07777351 0,15447243 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,07777351 0,15433915 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,07777351 0,1542061 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,07777351 0,15407328 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,07777351 0,15394069 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,07777351 0,15380832 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,07777351 0,15367618 ! phosphate transport GO:0006817 10 8 0,000 0,07777351 0,15354427 ! N-glycan processing GO:0006491 12 8 0,000 0,07777351 0,15341259 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,07777351 0,15328113 ! UTP metabolic process GO:0046051 8 8 0,000 0,07777351 0,1531499 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,07777351 0,15301889 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,07777351 0,1528881 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,07777351 0,15275754 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,07777351 0,1526272 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,07777351 0,15249708 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,07777351 0,15236719 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,07777351 0,15223751 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,07777351 0,15210806 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,07777351 0,15197883 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,07777351 0,15184981 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,07777351 0,15172102 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,07777351 0,15159244 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,07777351 0,15146408 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,07777351 0,15133594 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,07777351 0,15120801 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,07777351 0,1510803 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,07777351 0,15095281 ! astrocyte differentiation GO:0048708 16 8 0,000 0,07777351 0,15082553 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,07777351 0,15069846 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,07777351 0,15057161 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,07777351 0,15044498 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,07777351 0,15031855 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,07777351 0,15019234 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,07777351 0,15006634 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,07777351 0,14994055 ! macrophage activation GO:0042116 12 8 0,000 0,07777351 0,14981497 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,07777351 0,1496896 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,07777351 0,14956445 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,07777351 0,1494395 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,07777351 0,14931476 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,07777351 0,14919022 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,07777351 0,1490659 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,07777351 0,14894178 ! ruffle organization GO:0031529 11 8 0,000 0,07777351 0,14881787 ! osteoblast development GO:0002076 13 8 0,000 0,07777351 0,14869416 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,07777351 0,14857066 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,07777351 0,14844737 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,07777351 0,14832428 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,07777351 0,14820139 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,07777351 0,14807871 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,07777351 0,14795623 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,07777351 0,14783395 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,07777351 0,14771187 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,07777351 0,14759 ! brain morphogenesis GO:0048854 20 8 0,000 0,07777351 0,14746832 ! oligodendrocyte development GO:0014003 8 8 0,000 0,07777351 0,14734685 ! segment specification GO:0007379 10 8 0,000 0,07777351 0,14722558 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,07777351 0,1471045 ! cellular extravasation GO:0045123 11 8 0,000 0,07777351 0,14698363 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,07777351 0,14686295 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,07777351 0,14674248 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,07777351 0,14662219 ! snRNA metabolic process GO:0016073 10 8 0,000 0,07777351 0,14650211 GO:0016180|snRNA processing, ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,07777351 0,14638222 ! nucleosome disassembly GO:0006337 12 8 0,000 0,07777351 0,14626253 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,07777351 0,14614304 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,07777351 0,14602374 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,07777351 0,14590463 ! icosanoid secretion GO:0032309 12 8 0,000 0,07777351 0,14578572 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,07777351 0,145667 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,07777351 0,14554848 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,07777351 0,14543014 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,07777351 0,145312 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,07777351 0,14519406 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,07777351 0,1450763 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,07777351 0,14495873 ! sterol catabolic process GO:0016127 9 8 0,000 0,07777351 0,14484136 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,07777351 0,14472417 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,07777351 0,14460718 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,07777351 0,14449037 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,07777351 0,14437375 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,07777351 0,14425732 ! prophase GO:0051324 11 8 0,000 0,07777351 0,14414108 ! S phase GO:0051320 8 8 0,000 0,07777351 0,14402502 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,07777351 0,14390915 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,07777351 0,14379347 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,07777351 0,14367797 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,07777351 0,14356266 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,07777351 0,14344754 ! hormone catabolic process GO:0042447 13 8 0,000 0,07777351 0,14333259 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,07777351 0,14321784 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,07777351 0,14310326 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,07777351 0,14298887 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,07777351 0,14287466 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,07777351 0,14276064 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,07777351 0,14264679 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,07777351 0,14253313 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,07777351 0,14241965 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,07777351 0,14230635 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,07777351 0,14219323 ! lamellipodium assembly GO:0030032 9 8 0,000 0,07777351 0,14208028 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,07777351 0,14196752 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,07777351 0,14185494 ! regulation of ossification GO:0030278 71 46 1,000 0,07822099 0,14255806 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,07822099 0,14244519 ! viral infectious cycle GO:0019058 71 47 1,000 0,08117485 0,14770741 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,08117485 0,14759065 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,08117485 0,14747406 ! chloride transport GO:0006821 67 48 1,000 0,08416281 0,15278175 ! response to temperature stimulus GO:0009266 62 48 1,000 0,08416281 0,15266126 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,08416281 0,15254096 ! gastrulation GO:0007369 73 48 1,000 0,08416281 0,15242084 ! heart morphogenesis GO:0003007 65 48 1,000 0,08416281 0,15230092 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,08416281 0,15218119 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,08706228 0,15730026 ! regulation of developmental growth GO:0048638 13 9 0,000 0,08706228 0,15717679 ! telencephalon cell migration GO:0022029 16 9 0,000 0,08706228 0,15705352 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08706228 0,15693043 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08706228 0,15680754 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08706228 0,15668485 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,08706228 0,15656234 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,08706228 0,15644003 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,08706228 0,1563179 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,08706228 0,15619597 ! GTP metabolic process GO:0046039 9 9 0,000 0,08706228 0,15607423 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08706228 0,15595268 ! social behavior GO:0035176 14 9 0,000 0,08706228 0,15583131 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,08706228 0,15571014 ! artery development GO:0060840 19 9 0,000 0,08706228 0,15558915 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,08706228 0,15546835 ! response to pain GO:0048265 16 9 0,000 0,08706228 0,15534774 ! protein complex disassembly GO:0043241 17 9 0,000 0,08706228 0,15522731 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08706228 0,15510708 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,08706228 0,15498702 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,08706228 0,15486716 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08706228 0,15474748 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08706228 0,15462798 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08706228 0,15450867 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08706228 0,15438954 ! protein targeting to ER GO:0045047 19 9 0,000 0,08706228 0,1542706 ! endoderm development GO:0007492 12 9 0,000 0,08706228 0,15415184 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08706228 0,15403326 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,08706228 0,15391486 ! arginine catabolic process GO:0006527 10 9 0,000 0,08706228 0,15379665 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,08706228 0,15367861 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08706228 0,15356076 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,08706228 0,15344309 ! V(D)J recombination GO:0033151 12 9 0,000 0,08706228 0,1533256 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,08706228 0,15320829 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08706228 0,15309116 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08706228 0,15297421 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08706228 0,15285743 ! mannose metabolic process GO:0006013 9 9 0,000 0,08706228 0,15274084 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,08706228 0,15262442 ! receptor clustering GO:0043113 15 9 0,000 0,08706228 0,15250818 ! epithelial cell development GO:0002064 10 9 0,000 0,08706228 0,15239211 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08706228 0,15227622 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08706228 0,15216051 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08706228 0,15204498 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08706228 0,15192962 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08706228 0,15181443 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08706228 0,15169942 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,08706228 0,15158458 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08706228 0,15146992 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08706228 0,15135543 ! DNA ligation GO:0006266 14 9 0,000 0,08706228 0,15124111 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,08706228 0,15112697 ! response to amine stimulus GO:0014075 13 9 0,000 0,08706228 0,151013 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08706228 0,1508992 ! erythrocyte development GO:0048821 11 9 0,000 0,08706228 0,15078557 ! renal water homeostasis GO:0003091 14 9 0,000 0,08706228 0,15067211 ! postreplication repair GO:0006301 11 9 0,000 0,08706228 0,15055882 ! mRNA cleavage GO:0006379 13 9 0,000 0,08706228 0,15044571 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08706228 0,15033276 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08706228 0,15021998 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,08706228 0,15010737 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08706228 0,14999493 ! acid secretion GO:0046717 14 9 0,000 0,08706228 0,14988266 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08706228 0,14977056 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08706228 0,14965862 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,08706228 0,14954685 ! purine base metabolic process GO:0006144 18 9 0,000 0,08706228 0,14943525 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08706228 0,14932381 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08706228 0,14921254 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08706228 0,14910144 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,08706228 0,1489905 ! detection of calcium ion GO:0005513 13 9 0,000 0,08706228 0,14887973 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08706228 0,14876912 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08706228 0,14865867 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08706228 0,14854839 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08706228 0,14843828 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08706228 0,14832832 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08706228 0,14821853 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08706228 0,1481089 ! prepulse inhibition GO:0060134 14 9 0,000 0,08706228 0,14799943 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,08706228 0,14789013 ! insulin secretion GO:0030073 17 9 0,000 0,08706228 0,14778099 ! sequestering of metal ion GO:0051238 11 9 0,000 0,08706228 0,147672 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08706228 0,14756318 ! nucleus localization GO:0051647 15 9 0,000 0,08706228 0,14745452 ! regulation of synapse organization GO:0050807 12 9 0,000 0,08706228 0,14734602 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,08718389 0,14744334 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,09023713 0,15249477 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,09332157 0,15759149 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,09332157 0,15747587 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,09332157 0,15736042 ! adult behavior GO:0030534 80 51 1,000 0,09332157 0,15724514 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09625801 0,16207425 ! neuron fate specification GO:0048665 11 10 0,000 0,09625801 0,16195568 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09625801 0,1618373 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,09625801 0,16171908 ! thyroid gland development GO:0030878 19 10 0,000 0,09625801 0,16160104 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,09625801 0,16148317 ! synapsis GO:0007129 13 10 0,000 0,09625801 0,16136547 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,09625801 0,16124794 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09625801 0,16113058 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,09625801 0,1610134 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09625801 0,16089638 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,09625801 0,16077954 ! androgen metabolic process GO:0008209 13 10 0,000 0,09625801 0,16066286 ! phospholipid efflux GO:0033700 16 10 0,000 0,09625801 0,16054635 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,09625801 0,16043001 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,09625801 0,16031385 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09625801 0,16019784 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,09625801 0,16008201 ! pathogenesis GO:0009405 13 10 0,000 0,09625801 0,15996634 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09625801 0,15985084 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09625801 0,15973551 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09625801 0,15962035 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,09625801 0,15950535 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09625801 0,15939051 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09625801 0,15927584 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,09625801 0,15916134 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09625801 0,159047 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09625801 0,15893282 ! response to X-ray GO:0010165 16 10 0,000 0,09625801 0,15881881 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,09625801 0,15870496 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09625801 0,15859128 ! forebrain cell migration GO:0021885 17 10 0,000 0,09625801 0,15847775 ! lipid digestion GO:0044241 15 10 0,000 0,09625801 0,15836439 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09625801 0,15825119 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09625801 0,15813816 ! UV protection GO:0009650 14 10 0,000 0,09625801 0,15802528 ! entry into host cell GO:0030260 20 10 0,000 0,09625801 0,15791257 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09625801 0,15780001 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,09625801 0,15768762 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09625801 0,15757539 ! regulation of organ growth GO:0046620 11 10 0,000 0,09625801 0,15746331 ! response to dsRNA GO:0043331 18 10 0,000 0,09625801 0,1573514 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09625801 0,15723965 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09625801 0,15712805 ! embryonic axis specification GO:0000578 12 10 0,000 0,09625801 0,15701661 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09625801 0,15690533 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09625801 0,15679421 ! fucose catabolic process GO:0019317 16 10 0,000 0,09625801 0,15668324 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,09625801 0,15657243 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09625801 0,15646178 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,09625801 0,15635129 ! zymogen activation GO:0031638 14 10 0,000 0,09625801 0,15624095 ! salivary gland development GO:0007431 22 10 0,000 0,09625801 0,15613076 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09625801 0,15602073 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09625801 0,15591086 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09625801 0,15580114 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09625801 0,15569158 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09625801 0,15558216 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09625801 0,15547291 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09625801 0,1553638 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,09625801 0,15525485 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09625801 0,15514605 ! detection of bacterium GO:0016045 10 10 0,000 0,09625801 0,15503741 ! embryonic gut development GO:0048566 11 10 0,000 0,09625801 0,15492892 ! activation of innate immune response GO:0002218 10 10 0,000 0,09625801 0,15482057 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09625801 0,15471238 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,09625801 0,15460434 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,09625801 0,15449646 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,09625801 0,15438872 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,0964363 0,1545669 ! establishment of organelle localization GO:0051656 85 52 1,000 0,0964363 0,15445926 ! kidney development GO:0001822 90 53 1,000 0,0995804 0,15938408 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,10275297 0,16434759 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,10275297 0,16423338 ! detection of external stimulus GO:0009581 66 54 1,000 0,10275297 0,16411933 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,10275297 0,16400544 ! rRNA transcription GO:0009303 17 11 0,000 0,10536164 0,16805254 ! respiratory burst GO:0045730 14 11 0,000 0,10536164 0,16793608 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,10536164 0,16781978 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,10536164 0,16770364 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,10536164 0,16758767 ! virus-host interaction GO:0019048 17 11 0,000 0,10536164 0,16747185 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,10536164 0,16735619 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,10536164 0,16724069 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,10536164 0,16712536 ! RNA polyadenylation GO:0043631 19 11 0,000 0,10536164 0,16701018 ! mating GO:0007618 14 11 0,000 0,10536164 0,16689515 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,10536164 0,16678029 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,10536164 0,16666559 ! bone resorption GO:0045453 16 11 0,000 0,10536164 0,16655104 ! regulated secretory pathway GO:0045055 14 11 0,000 0,10536164 0,16643665 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,10536164 0,16632242 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,10536164 0,16620834 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,10536164 0,16609442 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,10536164 0,16598066 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,10536164 0,16586705 ! syncytium formation GO:0006949 15 11 0,000 0,10536164 0,1657536 ! plasma membrane organization GO:0007009 18 11 0,000 0,10536164 0,1656403 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,10536164 0,16552716 ! mitotic spindle organization GO:0007052 15 11 0,000 0,10536164 0,16541417 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,10536164 0,16530134 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,10536164 0,16518866 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,10536164 0,16507613 ! adult heart development GO:0007512 11 11 0,000 0,10536164 0,16496376 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,10536164 0,16485154 ! temperature homeostasis GO:0001659 16 11 0,000 0,10536164 0,16473947 ! L-glutamate transport GO:0015813 16 11 0,000 0,10536164 0,16462756 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,10536164 0,16451579 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,10536164 0,16440418 ! stem cell development GO:0048864 29 11 0,000 0,10536164 0,16429272 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,10536164 0,16418141 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,10536164 0,16407025 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,10536164 0,16395925 ! vasoconstriction GO:0042310 15 11 0,000 0,10536164 0,16384839 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,10536164 0,16373768 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,10536164 0,16362712 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,10536164 0,16351671 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,10536164 0,16340645 ! ribosome assembly GO:0042255 13 11 0,000 0,10536164 0,16329634 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,10536164 0,16318637 GO:0006809|nitric oxide biosynthetic process, ! nucleosome positioning GO:0016584 13 11 0,000 0,10536164 0,16307656 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,10536164 0,16296689 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,10536164 0,16285737 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,10536164 0,162748 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,10536164 0,16263877 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,10536164 0,16252969 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,10536164 0,16242075 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,10536164 0,16231197 ! male genitalia development GO:0030539 13 11 0,000 0,10536164 0,16220332 ! cholesterol efflux GO:0033344 19 11 0,000 0,10536164 0,16209483 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,10536164 0,16198647 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,10536164 0,16187827 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,10536164 0,1617702 ! defense response to fungus GO:0050832 12 11 0,000 0,10536164 0,16166228 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,10536164 0,16155451 ! lysogeny GO:0030069 18 11 0,000 0,10536164 0,16144688 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,10536164 0,16133939 ! acrosome reaction GO:0007340 13 11 0,000 0,10536164 0,16123205 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,10536164 0,16112484 ! mesoderm development GO:0007498 76 55 1,000 0,10595313 0,16192173 ! carbohydrate transport GO:0008643 74 57 1,000 0,11243275 0,17171005 ! chromosome segregation GO:0007059 83 57 1,000 0,11243275 0,1715961 ! secondary metabolic process GO:0019748 84 57 1,000 0,11243275 0,17148231 ! developmental maturation GO:0021700 75 57 1,000 0,11243275 0,17136867 ! gonad development GO:0008406 79 57 1,000 0,11243275 0,17125518 ! lactation GO:0007595 20 12 0,000 0,11437408 0,17409688 ! reproductive cellular process GO:0048610 14 12 0,000 0,11437408 0,17398173 ! tRNA modification GO:0006400 14 12 0,000 0,11437408 0,17386674 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,11437408 0,1737519 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,11437408 0,17363721 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,11437408 0,17352268 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,11437408 0,17340829 ! non-recombinational repair GO:0000726 19 12 0,000 0,11437408 0,17329406 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,11437408 0,17317997 ! peroxisomal transport GO:0043574 21 12 0,000 0,11437408 0,17306604 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,11437408 0,17295225 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,11437408 0,17283862 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,11437408 0,17272513 ! palate development GO:0060021 15 12 0,000 0,11437408 0,1726118 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,11437408 0,17249861 ! arginine metabolic process GO:0006525 13 12 0,000 0,11437408 0,17238557 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,11437408 0,17227268 ! methionine metabolic process GO:0006555 13 12 0,000 0,11437408 0,17215993 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,11437408 0,17204734 ! Golgi organization GO:0007030 18 12 0,000 0,11437408 0,17193489 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,11437408 0,17182259 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,11437408 0,17171043 ! monoamine transport GO:0015844 13 12 0,000 0,11437408 0,17159842 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,11437408 0,17148656 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,11437408 0,17137484 ! L-amino acid transport GO:0015807 20 12 0,000 0,11437408 0,17126327 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,11437408 0,17115184 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,11437408 0,17104056 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,11437408 0,17092942 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,11437408 0,17081843 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,11437408 0,17070758 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,11437408 0,17059687 ! cerebellum development GO:0021549 13 12 0,000 0,11437408 0,17048631 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,11437408 0,17037589 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,11437408 0,17026562 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,11437408 0,17015548 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,11437408 0,17004549 ! regulation of epidermis development GO:0045682 17 12 0,000 0,11437408 0,16993565 ! intestinal absorption GO:0050892 19 12 0,000 0,11437408 0,16982594 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,11437408 0,16971637 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,11437408 0,16960695 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,11437408 0,16949767 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,11437408 0,16938852 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,11437408 0,16927952 ! microspike assembly GO:0030035 23 12 0,000 0,11437408 0,16917066 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,11437408 0,16906194 ! response to cold GO:0009409 14 12 0,000 0,11437408 0,16895336 ! viral reproductive process GO:0022415 87 58 1,000 0,11571052 0,17081784 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,11571052 0,17070827 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,11901248 0,17546712 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,11901248 0,17535471 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,12233783 0,18013893 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,12329624 0,18143401 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,12329624 0,181318 ! cGMP metabolic process GO:0046068 16 13 0,000 0,12329624 0,18120214 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,12329624 0,18108643 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,12329624 0,18097087 ! lipid localization GO:0010876 24 13 0,000 0,12329624 0,18085545 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,12329624 0,18074018 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,12329624 0,18062506 ! organelle fusion GO:0048284 28 13 0,000 0,12329624 0,18051009 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,12329624 0,18039526 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,12329624 0,18028058 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,12329624 0,18016604 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,12329624 0,18005165 ! response to hexose stimulus GO:0009746 19 13 0,000 0,12329624 0,1799374 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,12329624 0,1798233 ! glutamate metabolic process GO:0006536 18 13 0,000 0,12329624 0,17970935 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,12329624 0,17959554 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,12329624 0,17948187 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,12329624 0,17936834 ! NAD metabolic process GO:0019674 21 13 0,000 0,12329624 0,17925496 ! exocrine system development GO:0035272 27 13 0,000 0,12329624 0,17914172 ! bone mineralization GO:0030282 15 13 0,000 0,12329624 0,17902863 ! regulation of exocytosis GO:0017157 17 13 0,000 0,12329624 0,17891568 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,12329624 0,17880287 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,12329624 0,1786902 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,12329624 0,17857768 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,12329624 0,17846529 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,12329624 0,17835305 ! genitalia development GO:0048806 15 13 0,000 0,12329624 0,17824095 ! regulation of cellular pH GO:0030641 20 13 0,000 0,12329624 0,17812899 ! tissue regeneration GO:0042246 21 13 0,000 0,12329624 0,17801717 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,12329624 0,17790549 ! cofactor transport GO:0051181 19 13 0,000 0,12329624 0,17779395 ! NADP metabolic process GO:0006739 18 13 0,000 0,12329624 0,17768255 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,12329624 0,17757129 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,12329624 0,17746017 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,12329624 0,17734919 ! gas transport GO:0015669 18 13 0,000 0,12329624 0,17723834 ! heme biosynthetic process GO:0006783 20 13 0,000 0,12329624 0,17712764 ! regulation of axon extension GO:0030516 23 13 0,000 0,12329624 0,17701707 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,12329624 0,17690664 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,12329624 0,17679635 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,12329624 0,1766862 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,12329624 0,17657618 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,12329624 0,1764663 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,12568577 0,17977442 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,12568577 0,17966269 ! fatty acid biosynthetic process GO:0006633 92 61 1,000 0,12568577 0,17955109 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,12568577 0,17943964 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! organelle localization GO:0051640 96 62 1,000 0,1290555 0,18413627 ! superoxide anion generation GO:0042554 18 14 0,000 0,13212902 0,18840468 ! neuron maturation GO:0042551 21 14 0,000 0,13212902 0,18828795 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,13212902 0,18817136 ! myotube differentiation GO:0014902 21 14 0,000 0,13212902 0,18805492 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,13212902 0,18793862 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,13212902 0,18782246 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,13212902 0,18770645 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,13212902 0,18759059 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,13212902 0,18747486 ! gene silencing by RNA GO:0031047 20 14 0,000 0,13212902 0,18735928 ! response to cAMP GO:0051591 19 14 0,000 0,13212902 0,18724384 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,13212902 0,18712854 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,13212902 0,18701338 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,13212902 0,18689837 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,13212902 0,1867835 ! glycine metabolic process GO:0006544 22 14 0,000 0,13212902 0,18666876 ! pituitary gland development GO:0021983 23 14 0,000 0,13212902 0,18655417 ! lysosomal transport GO:0007041 20 14 0,000 0,13212902 0,18643972 ! regulation of heart rate GO:0002027 23 14 0,000 0,13212902 0,18632541 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,13212902 0,18621124 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,13212902 0,18609721 ! embryo implantation GO:0007566 27 14 0,000 0,13212902 0,18598332 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,13212902 0,18586957 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,13212902 0,18575596 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,13212902 0,18564248 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,13212902 0,18552915 ! axon cargo transport GO:0008088 27 14 0,000 0,13212902 0,18541595 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,13212902 0,1853029 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,13212902 0,18518997 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,13212902 0,18507719 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,13212902 0,18496455 ! mRNA splice site selection GO:0006376 26 14 0,000 0,13212902 0,18485204 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,13212902 0,18473966 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,13212902 0,18462743 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,13212902 0,18451533 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,13212902 0,18440337 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,13212902 0,18429154 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,13212902 0,18417985 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,13212902 0,18406829 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,13212902 0,18395687 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,13212902 0,18384558 ! cell killing GO:0001906 20 14 0,000 0,13212902 0,18373443 ! cilium assembly GO:0042384 20 14 0,000 0,13212902 0,18362341 ! peptide hormone secretion GO:0030072 23 14 0,000 0,13212902 0,18351253 ! viral reproduction GO:0016032 92 63 1,000 0,13244627 0,18384214 ! regulation of lipase activity GO:0060191 109 63 1,000 0,13244627 0,18373126 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,13585732 0,18834951 ! appendage morphogenesis GO:0035107 93 64 1,000 0,13585732 0,18823604 GO:0035108|limb morphogenesis, ! adaptive immune response GO:0002250 94 64 1,000 0,13585732 0,18812272 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 1,000 0,13928789 0,19275701 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,13928789 0,1926411 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,13928789 0,19252533 ! activation of immune response GO:0002253 83 65 1,000 0,13928789 0,1924097 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,14087331 0,19448296 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,14087331 0,1943663 ! skin development GO:0043588 25 15 0,000 0,14087331 0,19424977 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,14087331 0,19413338 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,14087331 0,19401714 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,14087331 0,19390103 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,14087331 0,19378506 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,14087331 0,19366923 ! bile acid metabolic process GO:0008206 22 15 0,000 0,14087331 0,19355354 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,14087331 0,19343798 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,14087331 0,19332257 ! adult walking behavior GO:0007628 25 15 0,000 0,14087331 0,19320729 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,14087331 0,19309215 ! myoblast differentiation GO:0045445 27 15 0,000 0,14087331 0,19297714 ! centrosome cycle GO:0007098 16 15 0,000 0,14087331 0,19286227 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,14087331 0,19274754 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,14087331 0,19263295 ! cerebral cortex development GO:0021987 29 15 0,000 0,14087331 0,19251849 ! response to osmotic stress GO:0006970 22 15 0,000 0,14087331 0,19240417 ! vesicle coating GO:0006901 25 15 0,000 0,14087331 0,19228998 ! DNA integration GO:0015074 22 15 0,000 0,14087331 0,19217593 ! peptide secretion GO:0002790 27 15 0,000 0,14087331 0,19206202 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,14087331 0,19194823 ! regulation of vasodilation GO:0042312 24 15 0,000 0,14087331 0,19183459 ! neuron recognition GO:0008038 22 15 0,000 0,14087331 0,19172108 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,14087331 0,1916077 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,14087331 0,19149446 ! biomineral formation GO:0031214 18 15 0,000 0,14087331 0,19138135 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,14087331 0,19126837 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,14087331 0,19115553 ! dopamine metabolic process GO:0042417 30 15 0,000 0,14087331 0,19104282 ! organic cation transport GO:0015695 19 15 0,000 0,14087331 0,19093024 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,14087331 0,1908178 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,14087331 0,19070549 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,14087331 0,19059331 ! peptide hormone processing GO:0016486 19 15 0,000 0,14087331 0,19048126 ! regulation of immune effector process GO:0002697 101 66 1,000 0,14273725 0,19288818 ! protein secretion GO:0009306 27 16 0,000 0,14953 0,20194891 ! hormone secretion GO:0046879 25 16 0,000 0,14953 0,20183039 ! bone remodeling GO:0046849 24 16 0,000 0,14953 0,20171202 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14953 0,20159378 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14953 0,20147568 ! glial cell development GO:0021782 24 16 0,000 0,14953 0,20135772 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,14953 0,2012399 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,14953 0,20112222 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14953 0,20100467 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,14953 0,20088726 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,14953 0,20076999 ! fructose metabolic process GO:0006000 20 16 0,000 0,14953 0,20065285 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,14953 0,20053586 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,14953 0,20041899 ! protein export from nucleus GO:0006611 24 16 0,000 0,14953 0,20030227 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,14953 0,20018568 ! DNA replication initiation GO:0006270 25 16 0,000 0,14953 0,20006922 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14953 0,1999529 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,14953 0,19983672 ! diencephalon development GO:0021536 25 16 0,000 0,14953 0,19972067 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14953 0,19960475 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,14953 0,19948897 ! steroid catabolic process GO:0006706 22 16 0,000 0,14953 0,19937333 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14953 0,19925782 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14953 0,19914244 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14953 0,19902719 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14953 0,19891208 ! learning or memory GO:0007611 123 68 1,000 0,1496895 0,19900916 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,1496895 0,1988942 ! rhythmic process GO:0048511 105 68 1,000 0,1496895 0,19877936 ! inorganic anion transport GO:0015698 93 68 1,000 0,1496895 0,19866466 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,15319098 0,2031945 ! response to metal ion GO:0010038 103 70 1,000 0,15670845 0,20774031 ! humoral immune response GO:0006959 86 70 1,000 0,15670845 0,20762064 ! regulation of catabolic process GO:0009894 106 70 1,000 0,15670845 0,20750112 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,15809995 0,20922317 ! negative regulation of defense response GO:0031348 19 17 0,000 0,15809995 0,20910286 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,15809995 0,20898269 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,15809995 0,20886265 ! glycerol metabolic process GO:0006071 20 17 0,000 0,15809995 0,20874275 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,15809995 0,20862299 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,15809995 0,20850337 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,15809995 0,20838388 ! signal complex assembly GO:0007172 29 17 0,000 0,15809995 0,20826453 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,15809995 0,20814532 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,15809995 0,20802624 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,15809995 0,2079073 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,15809995 0,2077885 ! memory GO:0007613 25 17 0,000 0,15809995 0,20766983 ! keratinization GO:0031424 17 17 0,000 0,15809995 0,2075513 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,15809995 0,2074329 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,15809995 0,20731464 ! retinoid metabolic process GO:0001523 22 17 0,000 0,15809995 0,20719651 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,15809995 0,20707852 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,15809995 0,20696066 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,15809995 0,20684293 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,15809995 0,20672534 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,15809995 0,20660788 ! membrane budding GO:0006900 29 17 0,000 0,15809995 0,20649056 ! heme metabolic process GO:0042168 27 17 0,000 0,15809995 0,20637337 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,15809995 0,20625631 ! body fluid secretion GO:0007589 27 17 0,000 0,15809995 0,20613938 ! stem cell differentiation GO:0048863 36 17 0,000 0,15809995 0,20602259 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,15809995 0,20590593 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,15809995 0,2057894 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,15809995 0,20567301 ! sensory perception of pain GO:0019233 23 17 0,000 0,15809995 0,20555674 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,15809995 0,20544061 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,15809995 0,2053246 ! synaptogenesis GO:0007416 24 17 0,000 0,15809995 0,20520873 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,15809995 0,20509299 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,15809995 0,20497738 ! cell-cell junction organization GO:0045216 25 17 0,000 0,15809995 0,2048619 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,15809995 0,20474655 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,15809995 0,20463133 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,15809995 0,20451624 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,15809995 0,20440128 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,16024124 0,20705329 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,16024124 0,20693703 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,16378868 0,21139954 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,16658402 0,21488685 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,16658402 0,2147664 ! positive regulation of translation GO:0045727 28 18 0,000 0,16658402 0,21464608 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,16658402 0,2145259 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,16658402 0,21440585 ! cAMP metabolic process GO:0046058 33 18 0,000 0,16658402 0,21428593 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,16658402 0,21416616 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,16658402 0,21404651 ! axis specification GO:0009798 26 18 0,000 0,16658402 0,213927 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,16658402 0,21380762 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,16658402 0,21368837 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,16658402 0,21356926 ! glutamine metabolic process GO:0006541 23 18 0,000 0,16658402 0,21345028 ! response to retinoic acid GO:0032526 25 18 0,000 0,16658402 0,21333143 ! pigmentation during development GO:0048066 31 18 0,000 0,16658402 0,21321272 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,16658402 0,21309413 ! fucose metabolic process GO:0006004 26 18 0,000 0,16658402 0,21297568 ! response to fungus GO:0009620 19 18 0,000 0,16658402 0,21285736 ! peptide cross-linking GO:0018149 31 18 0,000 0,16658402 0,21273917 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,16658402 0,21262112 ! heart process GO:0003015 27 18 0,000 0,16658402 0,21250319 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,16658402 0,21238539 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,16658402 0,21226773 ! visual learning GO:0008542 35 18 0,000 0,16658402 0,21215019 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,16658402 0,21203279 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,16658402 0,21191552 ! vitamin transport GO:0051180 24 18 0,000 0,16658402 0,21179837 ! hormone transport GO:0009914 27 18 0,000 0,16658402 0,21168135 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,16658402 0,21156447 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,16658402 0,21144771 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,16658402 0,21133108 ! cell-cell recognition GO:0009988 20 18 0,000 0,16658402 0,21121458 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,16658402 0,21109821 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,16658402 0,21098197 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,16658402 0,21086585 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,16735014 0,2117191 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,16735014 0,21160271 ! response to inorganic substance GO:0010035 115 75 1,000 0,17451255 0,22053784 ! response to nutrient GO:0007584 104 75 1,000 0,17451255 0,22041673 ! regulation of ligase activity GO:0051340 114 75 1,000 0,17451255 0,22029576 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,17498308 0,22076856 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,17498308 0,22064753 ! positive regulation of ossification GO:0045778 30 19 0,000 0,17498308 0,22052663 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,17498308 0,22040586 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,17498308 0,22028522 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,17498308 0,22016471 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,17498308 0,22004434 ! sensory perception of taste GO:0050909 23 19 0,000 0,17498308 0,21992409 ! smooth muscle contraction GO:0006939 36 19 0,000 0,17498308 0,21980398 ! peroxisome organization GO:0007031 29 19 0,000 0,17498308 0,219684 ! digestive system process GO:0022600 30 19 0,000 0,17498308 0,21956415 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,17498308 0,21944443 ! response to vitamin A GO:0033189 26 19 0,000 0,17498308 0,21932485 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,17498308 0,21920539 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,17498308 0,21908606 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,17498308 0,21896686 ! plasma membrane fusion GO:0045026 23 19 0,000 0,17498308 0,21884779 ! cytolysis GO:0019835 20 19 0,000 0,17498308 0,21872886 ! vasodilation GO:0042311 33 19 0,000 0,17498308 0,21861005 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,17498308 0,21849136 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,17498308 0,21837281 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,17498308 0,21825439 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,17498308 0,21813609 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,17498308 0,21801793 ! sarcomere organization GO:0045214 23 19 0,000 0,17498308 0,21789989 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,17498308 0,21778198 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,17498308 0,21766419 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,17498308 0,21754654 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,17498308 0,21742901 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,17498308 0,21731161 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,17498308 0,21719433 ! regulation of protein transport GO:0051223 114 76 1,000 0,17811227 0,22095912 GO:0070201|regulation of establishment of protein localization, ! protein ubiquitination GO:0016567 125 77 1,000 0,18172351 0,22531756 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,18172351 0,22519616 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,18172351 0,22507489 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,18329798 0,22690277 ! iron ion transport GO:0006826 37 20 0,000 0,18329798 0,22678071 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,18329798 0,22665879 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,18329798 0,22653699 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,18329798 0,22641533 ! response to vitamin GO:0033273 29 20 0,000 0,18329798 0,2262938 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,18329798 0,2261724 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,18329798 0,22605112 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,18329798 0,22592998 ! spinal cord development GO:0021510 31 20 0,000 0,18329798 0,22580897 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,18329798 0,22568809 ! chromosome condensation GO:0030261 31 20 0,000 0,18329798 0,22556733 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,18329798 0,22544671 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,18329798 0,22532621 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,18329798 0,22520585 ! collagen fibril organization GO:0030199 45 20 0,000 0,18329798 0,22508561 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,18329798 0,2249655 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,18329798 0,22484552 ! collagen catabolic process GO:0030574 25 20 0,000 0,18329798 0,22472566 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,18329798 0,22460594 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,18329798 0,22448634 ! alditol metabolic process GO:0019400 24 20 0,000 0,18329798 0,22436687 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,19152954 0,23431805 GO:0016444|somatic cell DNA recombination, ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,19152954 0,23419348 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,19152954 0,23406904 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,19152954 0,23394474 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,19152954 0,23382056 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,19152954 0,23369652 ! vesicle docking GO:0048278 27 21 0,000 0,19152954 0,23357261 ! phototransduction GO:0007602 25 21 0,000 0,19152954 0,23344883 ! visual behavior GO:0007632 39 21 0,000 0,19152954 0,23332518 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,19152954 0,23320166 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,19152954 0,23307828 GO:0042278|purine nucleoside metabolic process, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,19152954 0,23295502 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,19152954 0,23283189 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,19152954 0,2327089 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,19152954 0,23258603 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,19152954 0,23246329 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,19152954 0,23234069 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,19152954 0,23221821 ! fatty acid transport GO:0015908 30 21 0,000 0,19152954 0,23209586 ! platelet activation GO:0030168 28 21 0,000 0,19152954 0,23197364 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,19152954 0,23185155 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,19152954 0,23172959 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,19152954 0,23160775 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,19152954 0,23148604 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,19152954 0,23136447 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,19152954 0,23124301 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,19152954 0,23112169 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,19152954 0,23100049 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,19152954 0,23087942 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,19152954 0,23075848 ! response to protein stimulus GO:0051789 111 81 1,000 0,19627212 0,23634863 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,1996786 0,24032485 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,1996786 0,24019916 ! viral genome replication GO:0019079 29 22 0,000 0,1996786 0,2400736 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,1996786 0,23994817 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,1996786 0,23982287 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,1996786 0,2396977 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,1996786 0,23957266 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,1996786 0,23944775 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,1996786 0,23932298 ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,1996786 0,23919833 ! lysosome organization GO:0007040 37 22 0,000 0,1996786 0,23907381 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,1996786 0,23894942 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,1996786 0,23882516 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,1996786 0,23870103 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,1996786 0,23857703 ! membrane depolarization GO:0051899 35 22 0,000 0,1996786 0,23845316 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,1996786 0,23832942 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,1996786 0,2382058 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,1996786 0,23808232 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,1996786 0,23795896 ! neural tube closure GO:0001843 33 22 0,000 0,1996786 0,23783573 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,1996786 0,23771262 ! protein tetramerization GO:0051262 39 22 0,000 0,1996786 0,23758965 ! detection of stimulus GO:0051606 108 82 1,000 0,19993235 0,23776857 ! neuron fate commitment GO:0048663 32 23 0,000 0,20774599 0,24693322 ! embryonic pattern specification GO:0009880 31 23 0,000 0,20774599 0,24680567 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,20774599 0,24667825 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,20774599 0,24655097 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,20774599 0,24642382 ! vesicle targeting GO:0006903 32 23 0,000 0,20774599 0,24629679 ! osteoblast differentiation GO:0001649 40 23 0,000 0,20774599 0,2461699 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,20774599 0,24604314 ! interaction with host GO:0051701 37 23 0,000 0,20774599 0,24591651 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,20774599 0,24579001 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,20774599 0,24566364 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,20774599 0,2455374 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,20774599 0,24541129 ! cell fate determination GO:0001709 45 23 0,000 0,20774599 0,24528531 ! pentose metabolic process GO:0019321 31 23 0,000 0,20774599 0,24515945 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,20774599 0,24503373 ! spermatid development GO:0007286 33 23 0,000 0,20774599 0,24490814 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,20774599 0,24478267 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,20774599 0,24465734 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,20774599 0,24453213 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,20774599 0,24440705 ! telomere organization GO:0032200 32 23 0,000 0,20774599 0,24428209 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,20774599 0,24415727 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,20774599 0,24403257 ! regulation of amine transport GO:0051952 38 23 0,000 0,20774599 0,243908 ! liver development GO:0001889 40 23 0,000 0,20774599 0,24378356 ! rRNA metabolic process GO:0016072 107 85 1,000 0,21095973 0,24742854 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,21095973 0,24730243 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,21573251 0,25276861 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,21573251 0,25263991 ! superoxide metabolic process GO:0006801 32 24 0,000 0,21573251 0,25251134 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,21573251 0,2523829 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,21573251 0,25225459 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,21573251 0,25212641 ! sperm motility GO:0030317 27 24 0,000 0,21573251 0,25199837 ! vacuole organization GO:0007033 39 24 0,000 0,21573251 0,25187045 ! receptor metabolic process GO:0043112 37 24 0,000 0,21573251 0,25174266 ! primary neural tube formation GO:0014020 35 24 0,000 0,21573251 0,251615 ! base-excision repair GO:0006284 31 24 0,000 0,21573251 0,25148747 ! glutathione metabolic process GO:0006749 29 24 0,000 0,21573251 0,25136007 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,21573251 0,2512328 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,21573251 0,25110566 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,21573251 0,25097864 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,22204629 0,25819337 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 1,000 0,22204629 0,2580629 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,22363898 0,25978265 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,22363898 0,25965152 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,22363898 0,25952051 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,22363898 0,25938964 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,22363898 0,2592589 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,22363898 0,25912829 ! peptide transport GO:0015833 43 25 0,000 0,22363898 0,25899781 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,22363898 0,25886746 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,22363898 0,25873725 ! phospholipid transport GO:0015914 35 25 0,000 0,22363898 0,25860717 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,22363898 0,25847721 ! detection of light stimulus GO:0009583 30 25 0,000 0,22363898 0,25834739 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,23146619 0,26725513 ! translational initiation GO:0006413 43 26 0,000 0,23146619 0,26712104 ! regulation of pH GO:0006885 36 26 0,000 0,23146619 0,26698707 ! circadian rhythm GO:0007623 42 26 0,000 0,23146619 0,26685325 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,23146619 0,26671955 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,23146619 0,26658599 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,23146619 0,26645257 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,23146619 0,26631927 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,23146619 0,26618611 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,23146619 0,26605309 ! regulation of coagulation GO:0050818 39 26 0,000 0,23146619 0,26592019 ! positive regulation of immune response GO:0050778 121 92 1,000 0,23689757 0,27202417 ! sulfur metabolic process GO:0006790 118 92 1,000 0,23689757 0,27188843 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,23921492 0,27441113 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,23921492 0,27427434 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,23921492 0,27413768 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,23921492 0,27400116 ! membrane docking GO:0022406 39 27 0,000 0,23921492 0,27386477 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,23921492 0,27372852 ! catechol metabolic process GO:0009712 43 27 0,000 0,23921492 0,2735924 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,23921492 0,27345642 ! acute-phase response GO:0006953 42 27 0,000 0,23921492 0,27332058 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,23921492 0,27318487 ! myofibril assembly GO:0030239 36 27 0,000 0,23921492 0,27304929 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,23921492 0,27291385 ! natural killer cell activation GO:0030101 35 27 0,000 0,23921492 0,27277854 ! cofactor catabolic process GO:0051187 45 27 0,000 0,23921492 0,27264337 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,23921492 0,27250833 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,23921492 0,27237343 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,24061964 0,27383729 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,24688597 0,28082974 ! phenol metabolic process GO:0018958 44 28 0,000 0,24688597 0,28069092 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,24688597 0,28055224 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,24688597 0,2804137 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,24688597 0,28027529 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,24688597 0,28013702 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,24688597 0,27999888 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,24688597 0,27986088 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,24688597 0,27972302 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,24688597 0,2795853 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,24688597 0,2794477 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,24688597 0,27931025 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,24688597 0,27917293 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,24688597 0,27903574 ! BMP signaling pathway GO:0030509 40 28 0,000 0,24688597 0,27889869 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,24688597 0,27876177 ! neural tube formation GO:0001841 41 28 0,000 0,24688597 0,27862499 ! protein maturation GO:0051604 129 96 1,000 0,25180097 0,28403249 ! regulation of innate immune response GO:0045088 38 29 0,000 0,25448011 0,28691385 ! protein targeting to membrane GO:0006612 53 29 0,000 0,25448011 0,28677327 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,25448011 0,28663284 ! mismatch repair GO:0006298 34 29 0,000 0,25448011 0,28649254 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,25448011 0,28635237 ! muscle cell development GO:0055001 38 29 0,000 0,25448011 0,28621235 ! eye morphogenesis GO:0048592 51 29 0,000 0,25448011 0,28607246 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,25448011 0,28593271 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,2619981 0,29423615 ! organic anion transport GO:0015711 51 30 0,000 0,2619981 0,29409255 ! cholesterol transport GO:0030301 46 30 0,000 0,2619981 0,29394909 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,2619981 0,29380577 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,2619981 0,29366259 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,2619981 0,29351955 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,2619981 0,29337665 ! ceramide metabolic process GO:0006672 43 30 0,000 0,2619981 0,29323388 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,2619981 0,29309126 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,2619981 0,29294878 ! calcium ion transport GO:0006816 167 99 1,000 0,26299622 0,29392191 ! extracellular structure organization GO:0043062 156 99 1,000 0,26299622 0,29377917 ! regulation of translation GO:0006417 151 100 1,000 0,26672918 0,29780442 ! divalent metal ion transport GO:0070838 171 100 1,000 0,26672918 0,29765993 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,2694407 0,30054007 ! negative regulation of secretion GO:0051048 49 31 0,000 0,2694407 0,30039439 ! glial cell differentiation GO:0010001 55 31 0,000 0,2694407 0,30024885 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,2694407 0,30010345 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,2694407 0,29995819 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,2694407 0,29981307 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,2694407 0,2996681 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,2694407 0,29952326 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,2694407 0,29937856 ! RNA modification GO:0009451 40 31 0,000 0,2694407 0,299234 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,27680867 0,30726832 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,27680867 0,30712009 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,27680867 0,30697201 ! cytokine production GO:0001816 44 32 0,000 0,27680867 0,30682407 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,27680867 0,30667628 ! vesicle localization GO:0051648 47 32 0,000 0,27680867 0,30652862 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,28410275 0,31445444 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,28410275 0,31430319 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,28410275 0,31415208 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,28410275 0,31400112 ! actomyosin structure organization GO:0031032 43 33 0,000 0,28410275 0,3138503 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,28410275 0,31369963 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,28410275 0,3135491 ! lipid homeostasis GO:0055088 55 33 0,000 0,28410275 0,31339872 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,28410275 0,31324848 ! regulation of proteolysis GO:0030162 50 33 0,000 0,28410275 0,31309839 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,28410275 0,31294843 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,28410275 0,31279863 ! mRNA catabolic process GO:0006402 48 34 0,000 0,29132368 0,32059543 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,29132368 0,32044211 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,29132368 0,32028894 ! feeding behavior GO:0007631 45 34 0,000 0,29132368 0,32013591 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,29132368 0,31998303 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,29132368 0,31983029 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,29132368 0,3196777 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,29132368 0,31952525 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,29132368 0,31937295 ! aerobic respiration GO:0009060 47 34 0,000 0,29132368 0,3192208 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,29132368 0,31906879 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,29847218 0,32674251 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,29847218 0,32658706 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,29847218 0,32643177 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,29847218 0,32627662 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,29847218 0,32612162 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,29847218 0,32596677 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,29847218 0,32581206 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,29847218 0,3256575 ! protein homooligomerization GO:0051260 52 35 0,000 0,29847218 0,32550309 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,30554898 0,33306286 ! organic ether metabolic process GO:0018904 46 36 0,000 0,30554898 0,33290509 ! neural tube development GO:0021915 50 36 0,000 0,30554898 0,33274746 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,30554898 0,33258999 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,30554898 0,33243266 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,30554898 0,33227548 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,31255479 0,33973346 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,31255479 0,33957299 ! ion transmembrane transport GO:0034220 56 37 0,000 0,31255479 0,33941266 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,31255479 0,33925248 ! regulation of protein secretion GO:0050708 51 37 0,000 0,31255479 0,33909246 ! amino acid activation GO:0043038 52 37 0,000 0,31255479 0,33893258 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,31255479 0,33877286 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,31949032 0,34612705 ! gliogenesis GO:0042063 71 38 0,000 0,31949032 0,34596409 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,31949032 0,34580129 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,31949032 0,34563863 ! phagocytosis GO:0006909 60 38 0,000 0,31949032 0,34547613 ! maintenance of location in cell GO:0051651 69 38 0,000 0,31949032 0,34531378 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,32635627 0,35256901 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,32635627 0,35240349 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,32635627 0,35223812 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,32635627 0,3520729 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,32635627 0,35190784 ! JNK cascade GO:0007254 54 39 0,000 0,32635627 0,35174294 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,33315334 0,35890056 ! response to calcium ion GO:0051592 58 40 0,000 0,33315334 0,35873253 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,33315334 0,35856467 ! regulation of tube size GO:0035150 60 40 0,000 0,33315334 0,35839696 GO:0050880|regulation of blood vessel size, ! peptide metabolic process GO:0006518 56 40 0,000 0,33315334 0,3582294 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,33315334 0,358062 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,33315334 0,35789476 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,33988222 0,36495289 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,33988222 0,36478259 ! striated muscle contraction GO:0006941 62 41 0,000 0,33988222 0,36461245 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,33988222 0,36444247 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,34654357 0,37141203 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,34654357 0,37123904 ! excretion GO:0007588 63 42 0,000 0,34654357 0,37106621 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,34654357 0,37089354 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,34654357 0,37072103 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,35313809 0,3776 ! tRNA processing GO:0008033 49 43 0,000 0,35313809 0,37742454 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,35966643 0,38422331 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,35966643 0,38404493 ! regulation of ion transport GO:0043269 57 44 0,000 0,35966643 0,38386672 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,35966643 0,38368867 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,35966643 0,38351079 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,35966643 0,38333308 ! RNA catabolic process GO:0006401 64 45 0,000 0,36612925 0,39004042 ! regulation of translational initiation GO:0006446 64 45 0,000 0,36612925 0,38985985 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,36612925 0,38967944 ! cell recognition GO:0008037 58 45 0,000 0,36612925 0,3894992 ! cell maturation GO:0048469 60 45 0,000 0,36612925 0,38931913 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,37252721 0,39593927 ! cell redox homeostasis GO:0045454 63 46 0,000 0,37252721 0,39575639 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,37252721 0,39557368 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,37886096 0,40211362 ! endocrine system development GO:0035270 83 47 0,000 0,37886096 0,40192814 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,37886096 0,40174283 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,37886096 0,4015577 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,37886096 0,40137273 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,37886096 0,40118794 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,38513113 0,40763995 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,38513113 0,40745244 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,38513113 0,4072651 ! regulation of endocytosis GO:0030100 63 48 0,000 0,38513113 0,40707794 ! nuclear export GO:0051168 69 48 0,000 0,38513113 0,40689095 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,39133837 0,41325906 ! sensory perception of smell GO:0007608 61 49 0,000 0,39133837 0,41306941 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,39133837 0,41287993 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,39133837 0,41269062 ! RNA elongation GO:0006354 62 49 0,000 0,39133837 0,41250149 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,39133837 0,41231252 ! maintenance of location GO:0051235 84 49 0,000 0,39133837 0,41212374 ! regulation of actin filament length GO:0030832 72 50 0,000 0,39748329 0,41840346 ! membrane fusion GO:0006944 80 50 0,000 0,39748329 0,41821206 ! proton transport GO:0015992 75 50 0,000 0,39748329 0,41802083 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,39748329 0,41782978 ! positive regulation of secretion GO:0051047 71 51 0,000 0,40356652 0,42403061 ! hydrogen transport GO:0006818 77 51 0,000 0,40356652 0,42383699 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,40356652 0,42364354 ! transition metal ion transport GO:0000041 74 52 0,000 0,40958868 0,42976915 ! regulation of cellular component size GO:0032535 74 52 0,000 0,40958868 0,42957318 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,40958868 0,42937738 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,40958868 0,42918177 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,41555038 0,43523036 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,41555038 0,43503226 ! single fertilization GO:0007338 59 53 0,000 0,41555038 0,43483434 ! cell projection assembly GO:0030031 76 53 0,000 0,41555038 0,4346366 ! amino acid transport GO:0006865 84 54 0,000 0,42145222 0,44060914 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,42145222 0,44040895 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,42145222 0,44020895 ! exocytosis GO:0006887 74 55 0,000 0,4272948 0,44610896 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,4272948 0,44590655 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,4272948 0,44570432 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,4330787 0,45153264 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,4330787 0,45132805 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,43880452 0,45708804 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,43880452 0,45688112 ! camera-type eye development GO:0043010 88 57 0,000 0,43880452 0,45667439 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,44447284 0,46236433 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,45008422 0,46798992 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,45563925 0,47355186 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,45563925 0,47333797 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,45563925 0,47312427 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,45563925 0,47291077 ! fertilization GO:0009566 68 60 0,000 0,45563925 0,47269746 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,46113847 0,47818687 ! extracellular matrix organization GO:0030198 103 61 0,000 0,46113847 0,47797138 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,46113847 0,47775607 ! amine catabolic process GO:0009310 90 62 0,000 0,46658245 0,48317859 ! neurotransmitter transport GO:0006836 81 62 0,000 0,46658245 0,48296114 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,46658245 0,48274388 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,46658245 0,48252682 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,47197175 0,48788091 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,4773069 0,49317424 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,4773069 0,49295279 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,48258844 0,49818376 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,48258844 0,49796026 ! defense response to bacterium GO:0042742 73 65 0,000 0,48258844 0,49773696 ! protein oligomerization GO:0051259 100 65 0,000 0,48258844 0,49751386 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,48781692 0,50267873 ! antigen processing and presentation GO:0019882 96 66 0,000 0,48781692 0,50245362 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,48781692 0,5022287 ! acute inflammatory response GO:0002526 92 68 0,000 0,4981168 0,51260342 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,4981168 0,51237417 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,4981168 0,51214512 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,50318924 0,51712924 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,50318924 0,51689828 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,5082107 0,52182348 ! eye development GO:0001654 111 70 0,000 0,5082107 0,52159063 ! amine transport GO:0015837 101 70 0,000 0,5082107 0,52135799 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,5082107 0,52112555 ! muscle cell differentiation GO:0042692 104 71 0,000 0,51318169 0,52598836 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,51318169 0,52575407 ! regulation of blood pressure GO:0008217 107 73 0,000 0,52297428 0,53554802 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,52779687 0,54024602 ! digestion GO:0007586 97 74 0,000 0,52779687 0,5400057 ! protein import into nucleus GO:0006606 118 74 0,000 0,52779687 0,53976559 ! blood coagulation GO:0007596 116 75 0,000 0,53257099 0,5444059 GO:0050817|coagulation, ! nuclear import GO:0051170 121 75 0,000 0,53257099 0,54416405 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,53257099 0,54392241 ! amine biosynthetic process GO:0009309 97 76 0,000 0,5372971 0,5485057 ! tRNA metabolic process GO:0006399 95 76 0,000 0,5372971 0,54826235 ! response to unfolded protein GO:0006986 99 76 0,000 0,5372971 0,54801922 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,5419757 0,55254615 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,5419757 0,55230134 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,54660726 0,55677445 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,54660726 0,55652798 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,55119225 0,56094786 ! cellular respiration GO:0045333 107 79 0,000 0,55119225 0,56069977 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,55119225 0,56045189 ! regulation of lyase activity GO:0051339 133 79 0,000 0,55119225 0,56020423 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,55119225 0,55995679 ! chromatin assembly GO:0031497 102 80 0,000 0,55573113 0,56431859 GO:0006334|nucleosome assembly, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,55573113 0,56406955 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,55573113 0,56382073 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,55573113 0,56357213 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,56022437 0,56787838 ! hemostasis GO:0007599 125 81 0,000 0,56022437 0,56762822 ! mRNA transport GO:0051028 121 81 0,000 0,56022437 0,56737827 ! vitamin metabolic process GO:0006766 103 81 0,000 0,56022437 0,56712854 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,56907573 0,57583554 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,56907573 0,57558231 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,57343476 0,57973624 ! sterol metabolic process GO:0016125 120 84 0,000 0,57343476 0,57948152 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,57774994 0,58358579 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,58202171 0,58764264 ! nucleosome organization GO:0034728 114 87 0,000 0,58625051 0,59165255 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,58625051 0,59139305 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,58625051 0,59113378 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,59043676 0,59509402 ! establishment of RNA localization GO:0051236 128 88 0,000 0,59043676 0,59483336 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,5945809 0,59874609 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,5945809 0,59848406 ! RNA localization GO:0006403 135 91 0,000 0,6027445 0,60643585 ! ATP metabolic process GO:0046034 137 91 0,000 0,6027445 0,60617068 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,6067648 0,60994713 ! DNA recombination GO:0006310 146 92 0,000 0,6067648 0,60968066 ! electron transport chain GO:0022900 123 94 0,000 0,61468442 0,61736863 ! carboxylic acid transport GO:0046942 147 95 0,000 0,61858456 0,62101462 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,62244544 0,62461802 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,62626746 0,62817931 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! protein import GO:0017038 156 99 0,000 0,63379646 0,63545416 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,63750421 0,63889311 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,63750421 0,63861484 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,63750421 0,63833682 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,63750421 0,63805904 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,63750421 0,6377815 ! protein localization in organelle GO:0033365 161 100 0,000 0,63750421 0,63750421