pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6709-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 9,000 1,826E-11 4,394E-08 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 6,000 6,094E-10 7,331E-07 ! regulation of cell adhesion GO:0030155 212 89 9,000 1,737E-09 1,393E-06 ! negative regulation of cell adhesion GO:0007162 81 35 6,000 7,987E-09 4,804E-06 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 4,000 1,131E-08 5,443E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of protein stability GO:0031647 73 37 6,000 1,207E-08 4,84E-06 ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,676E-08 5,761E-06 ! regulation of cell-matrix adhesion GO:0001952 78 23 5,000 1,727E-08 5,194E-06 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of phosphorylation GO:0042326 47 24 5,000 2,288E-08 6,116E-06 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 5,000 3,864E-08 9,296E-06 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 7,000 4,688E-08 1,025E-05 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 4,998E-08 1,002E-05 ! cell growth GO:0016049 84 45 6,000 5,05E-08 9,346E-06 ! negative regulation of cell migration GO:0030336 115 46 6,000 5,918E-08 1,017E-05 ! negative regulation of focal adhesion formation GO:0051895 20 7 3,000 1,159E-07 1,859E-05 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 4,000 1,459E-07 2,194E-05 ! negative regulation of cell motion GO:0051271 134 55 6,000 2,116E-07 2,995E-05 ! regulation of focal adhesion formation GO:0051893 22 8 3,000 2,304E-07 3,08E-05 ! induction of positive chemotaxis GO:0050930 15 9 3,000 4,123E-07 5,221E-05 ! positive regulation of locomotion GO:0040017 39 21 4,000 4,68E-07 5,63E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of homeostatic process GO:0032844 134 62 6,000 4,9E-07 5,614E-05 ! regulation of chemotaxis GO:0050920 40 22 4,000 6,018E-07 6,582E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 3,000 6,83E-07 7,145E-05 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 3,000 6,83E-07 6,847E-05 ! interphase of mitotic cell cycle GO:0051329 209 95 7,000 7,267E-07 6,994E-05 ! regulation of epithelial cell proliferation GO:0050678 111 43 5,000 9,175E-07 8,491E-05 ! interphase GO:0051325 213 98 7,000 9,225E-07 8,22E-05 ! regulation of behavior GO:0050795 43 24 4,000 9,593E-07 8,243E-05 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 5,000 1,383E-06 1,147E-04 ! regulation of B cell proliferation GO:0030888 20 12 3,000 1,591E-06 1,276E-04 ! regulation of positive chemotaxis GO:0050926 19 12 3,000 1,591E-06 1,234E-04 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of protein modification process GO:0031400 60 28 4,000 2,163E-06 1,627E-04 ! embryonic placenta development GO:0001892 23 13 3,000 2,284E-06 1,665E-04 ! positive regulation of phosphorylation GO:0042327 129 79 6,000 2,586E-06 1,83E-04 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 6,000 3,062E-06 2,105E-04 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 3,000 3,178E-06 2,124E-04 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 3,000 4,307E-06 2,801E-04 ! epithelial to mesenchymal transition GO:0001837 28 15 3,000 4,307E-06 2,727E-04 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 2,000 4,404E-06 2,717E-04 ! positive regulation of cell migration GO:0030335 126 57 5,000 4,994E-06 3,004E-04 ! lipid modification GO:0030258 97 57 5,000 4,994E-06 2,93E-04 ! regulation of protein ubiquitination GO:0031396 25 16 3,000 5,709E-06 3,27E-04 ! placenta development GO:0001890 53 34 4,000 5,9E-06 3,301E-04 ! regulation of cell cycle process GO:0010564 149 90 6,000 6,206E-06 3,393E-04 ! endothelial cell migration GO:0043542 28 17 3,000 7,42E-06 3,967E-04 ! inositol metabolic process GO:0006020 28 17 3,000 7,42E-06 3,881E-04 ! cardiac muscle tissue development GO:0048738 31 17 3,000 7,42E-06 3,799E-04 ! neural nucleus development GO:0048857 14 6 2,000 8,758E-06 4,39E-04 ! maternal placenta development GO:0001893 12 6 2,000 8,758E-06 4,3E-04 ! forebrain development GO:0030900 188 95 6,000 8,885E-06 4,276E-04 ! positive regulation of cell motion GO:0051272 146 64 5,000 9,866E-06 4,655E-04 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 3,000 1,194E-05 5,524E-04 ! negative regulation of protein kinase activity GO:0006469 130 67 5,000 1,288E-05 5,849E-04 ! mesenchymal cell development GO:0014031 87 40 4,000 1,344E-05 5,987E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of kinase activity GO:0033673 131 68 5,000 1,404E-05 6,142E-04 ! C21-steroid hormone metabolic process GO:0008207 33 20 3,000 1,483E-05 6,374E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 1,483E-05 6,262E-04 ! regulation of T cell differentiation GO:0045580 70 41 4,000 1,521E-05 6,309E-04 ! positive regulation of protein ubiquitination GO:0031398 12 7 2,000 1,524E-05 6,215E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 1,524E-05 6,111E-04 ! positive regulation of response to external stimulus GO:0032103 77 43 4,000 1,929E-05 7,61E-04 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 5,000 1,954E-05 7,582E-04 ! negative regulation of transferase activity GO:0051348 140 72 5,000 1,954E-05 7,461E-04 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 2,418E-05 9,092E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 2,424E-05 8,974E-04 ! dendrite morphogenesis GO:0048813 13 8 2,000 2,424E-05 8,838E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 2,424E-05 8,706E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 2,424E-05 8,578E-04 ! sex determination GO:0007530 47 23 3,000 2,663E-05 9,285E-04 ! lymphocyte proliferation GO:0046651 48 24 3,000 3,176E-05 1,092E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 4,000 3,327E-05 1,127E-03 ! regulation of mast cell proliferation GO:0070666 81 48 4,000 3,327E-05 1,112E-03 ! axon extension GO:0048675 15 9 2,000 3,616E-05 1,192E-03 ! T cell selection GO:0045058 23 9 2,000 3,616E-05 1,176E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 2,000 3,616E-05 1,16E-03 ! motor axon guidance GO:0008045 16 9 2,000 3,616E-05 1,145E-03 ! positive regulation of erythrocyte differentiation GO:0045648 29 9 2,000 3,616E-05 1,13E-03 ! response to hypoxia GO:0001666 171 81 5,000 3,832E-05 1,182E-03 ! response to oxygen levels GO:0070482 176 83 5,000 4,4E-05 1,34E-03 ! leukocyte proliferation GO:0070661 52 26 3,000 4,415E-05 1,328E-03 GO:0032943|mononuclear cell proliferation, ! regulation of leukocyte proliferation GO:0070663 88 51 4,000 4,479E-05 1,331E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 90 52 4,000 4,925E-05 1,445E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 5,137E-05 1,489E-03 ! positive regulation of B cell proliferation GO:0030890 16 10 2,000 5,137E-05 1,471E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 5,137E-05 1,454E-03 ! negative regulation of striated muscle development GO:0045843 19 10 2,000 5,137E-05 1,437E-03 ! central nervous system neuron axonogenesis GO:0021955 22 10 2,000 5,137E-05 1,421E-03 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 5,137E-05 1,404E-03 ! protein sumoylation GO:0016925 15 10 2,000 5,137E-05 1,389E-03 ! positive regulation of leukocyte migration GO:0002687 25 10 2,000 5,137E-05 1,373E-03 ! blastocyst formation GO:0001825 17 10 2,000 5,137E-05 1,358E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 5,137E-05 1,343E-03 ! dendrite development GO:0016358 59 28 3,000 5,974E-05 1,546E-03 ! positive regulation of protein modification process GO:0031401 136 88 5,000 6,12E-05 1,566E-03 ! negative regulation of muscle development GO:0048635 20 11 2,000 7,023E-05 1,779E-03 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 2,000 7,023E-05 1,76E-03 ! T cell proliferation GO:0042098 26 11 2,000 7,023E-05 1,742E-03 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 2,000 7,023E-05 1,724E-03 ! chondrocyte differentiation GO:0002062 24 11 2,000 7,023E-05 1,707E-03 ! regulation of leukocyte migration GO:0002685 26 11 2,000 7,023E-05 1,69E-03 ! negative regulation of glucose import GO:0046325 17 11 2,000 7,023E-05 1,673E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of protein kinase cascade GO:0010741 68 30 3,000 7,901E-05 1,864E-03 ! regulation of B cell activation GO:0050864 50 30 3,000 7,901E-05 1,846E-03 ! positive regulation of MAP kinase activity GO:0043406 160 93 5,000 8,338E-05 1,929E-03 ! hippocampus development GO:0021766 26 12 2,000 9,311E-05 2,133E-03 ! focal adhesion formation GO:0048041 35 12 2,000 9,311E-05 2,113E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 9,311E-05 2,094E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of DNA metabolic process GO:0051052 178 97 5,000 1,054E-04 2,348E-03 ! ear development GO:0043583 103 62 4,000 1,152E-04 2,543E-03 ! regulation of monooxygenase activity GO:0032768 33 13 2,000 1,204E-04 2,632E-03 ! regulation of mitosis GO:0007088 105 63 4,000 1,244E-04 2,696E-03 GO:0051783|regulation of nuclear division, ! regulation of striated muscle tissue development GO:0016202 69 34 3,000 1,305E-04 2,804E-03 ! regulation of muscle development GO:0048634 70 35 3,000 1,465E-04 3,119E-03 ! T cell differentiation in the thymus GO:0033077 31 14 2,000 1,523E-04 3,215E-03 ! regulation of erythrocyte differentiation GO:0045646 44 14 2,000 1,523E-04 3,187E-03 ! release of cytochrome c from mitochondria GO:0001836 30 14 2,000 1,523E-04 3,159E-03 ! hormone biosynthetic process GO:0042446 57 36 3,000 1,638E-04 3,369E-03 ! androgen receptor signaling pathway GO:0030521 74 36 3,000 1,638E-04 3,34E-03 ! negative regulation of bone remodeling GO:0046851 33 15 2,000 1,893E-04 3,828E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 1,893E-04 3,796E-03 ! G1 phase of mitotic cell cycle GO:0000080 35 16 2,000 2,317E-04 4,607E-03 ! negative regulation of microtubule depolymerization GO:0007026 46 16 2,000 2,317E-04 4,569E-03 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of tissue remodeling GO:0034104 36 16 2,000 2,317E-04 4,532E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 2,317E-04 4,495E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 37 16 2,000 2,317E-04 4,459E-03 ! phosphoinositide metabolic process GO:0030384 128 72 4,000 2,341E-04 4,471E-03 ! regulation of T cell proliferation GO:0042129 71 41 3,000 2,733E-04 5,178E-03 ! polyol metabolic process GO:0019751 66 41 3,000 2,733E-04 5,137E-03 ! limbic system development GO:0021761 36 17 2,000 2,797E-04 5,217E-03 ! regulation of protein binding GO:0043393 33 17 2,000 2,797E-04 5,177E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 2,797E-04 5,138E-03 ! neutrophil chemotaxis GO:0030593 27 17 2,000 2,797E-04 5,099E-03 ! negative regulation of homeostatic process GO:0032845 33 17 2,000 2,797E-04 5,06E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 2,000 2,797E-04 5,023E-03 ! cell-matrix adhesion GO:0007160 163 75 4,000 2,835E-04 5,053E-03 ! neuron migration GO:0001764 79 42 3,000 3,003E-04 5,312E-03 ! cell-substrate junction assembly GO:0007044 54 18 2,000 3,338E-04 5,862E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 3,338E-04 5,82E-03 ! JAK-STAT cascade GO:0007259 71 44 3,000 3,598E-04 6,228E-03 ! cellular pigmentation GO:0033059 36 19 2,000 3,941E-04 6,773E-03 ! G1 phase GO:0051318 40 19 2,000 3,941E-04 6,725E-03 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 2,000 3,941E-04 6,678E-03 ! T cell activation GO:0042110 168 81 4,000 4,055E-04 6,822E-03 ! cell-substrate adhesion GO:0031589 171 81 4,000 4,055E-04 6,775E-03 ! pigmentation GO:0043473 100 46 3,000 4,274E-04 7,092E-03 ! response to alkaloid GO:0043279 38 20 2,000 4,611E-04 7,598E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 4,611E-04 7,546E-03 ! regulation of glucose import GO:0046324 29 20 2,000 4,611E-04 7,495E-03 GO:0010827|regulation of glucose transport, ! inner ear receptor cell differentiation GO:0060113 37 20 2,000 4,611E-04 7,445E-03 ! negative regulation of T cell activation GO:0050868 40 20 2,000 4,611E-04 7,396E-03 ! negative regulation of growth GO:0045926 155 84 4,000 4,796E-04 7,641E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 5,349E-04 8,467E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 5,349E-04 8,411E-03 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 5,349E-04 8,357E-03 ! response to cytokine stimulus GO:0034097 63 21 2,000 5,349E-04 8,303E-03 ! negative regulation of protein ubiquitination GO:0031397 9 5 1,000 5,769E-04 8,898E-03 ! hemoglobin biosynthetic process GO:0042541 7 5 1,000 5,769E-04 8,841E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,769E-04 8,785E-03 ! negative regulation of cell-cell adhesion GO:0022408 12 5 1,000 5,769E-04 8,73E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,769E-04 8,675E-03 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 1,000 5,769E-04 8,622E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 5,769E-04 8,568E-03 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 5,769E-04 8,516E-03 ! valine metabolic process GO:0006573 10 5 1,000 5,769E-04 8,464E-03 ! mRNA transcription GO:0009299 9 5 1,000 5,769E-04 8,412E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 5,769E-04 8,362E-03 ! paraxial mesoderm development GO:0048339 14 5 1,000 5,769E-04 8,312E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 5,769E-04 8,262E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 5,769E-04 8,213E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 5,769E-04 8,165E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 5,769E-04 8,117E-03 ! negative regulation of T cell mediated immunity GO:0002710 12 5 1,000 5,769E-04 8,07E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! decidualization GO:0046697 11 5 1,000 5,769E-04 8,023E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 5,769E-04 7,977E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 1,000 5,769E-04 7,932E-03 ! B cell homeostasis GO:0001782 13 5 1,000 5,769E-04 7,887E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 1,000 5,769E-04 7,842E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 5,769E-04 7,798E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 5,769E-04 7,755E-03 ! regulation of sensory perception GO:0051931 7 5 1,000 5,769E-04 7,711E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 5,769E-04 7,669E-03 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 5,769E-04 7,627E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! stem cell division GO:0017145 11 5 1,000 5,769E-04 7,585E-03 GO:0048103|somatic stem cell division, ! histone modification GO:0016570 91 50 3,000 5,889E-04 7,7E-03 ! negative regulation of immune system process GO:0002683 95 50 3,000 5,889E-04 7,659E-03 ! gland development GO:0048732 206 88 4,000 5,937E-04 7,68E-03 ! mechanoreceptor differentiation GO:0042490 40 22 2,000 6,158E-04 7,924E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 6,158E-04 7,881E-03 ! central nervous system neuron development GO:0021954 46 22 2,000 6,158E-04 7,84E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 6,158E-04 7,798E-03 ! positive regulation of B cell activation GO:0050871 38 22 2,000 6,158E-04 7,758E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 2,000 6,158E-04 7,717E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 3,000 6,352E-04 7,918E-03 ! vesicle organization GO:0016050 107 51 3,000 6,352E-04 7,878E-03 ! regulation of cell shape GO:0008360 125 51 3,000 6,352E-04 7,837E-03 ! positive regulation of growth GO:0045927 90 52 3,000 6,84E-04 8,397E-03 ! covalent chromatin modification GO:0016569 101 52 3,000 6,84E-04 8,354E-03 ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 7,042E-04 8,557E-03 ! response to UV GO:0009411 104 53 3,000 7,354E-04 8,892E-03 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 2,000 8,003E-04 9,627E-03 ! central nervous system neuron differentiation GO:0021953 50 24 2,000 8,003E-04 9,58E-03 ! regulation of alpha-beta T cell activation GO:0046634 42 24 2,000 8,003E-04 9,532E-03 ! pallium development GO:0021543 49 24 2,000 8,003E-04 9,485E-03 ! regulation of oxidoreductase activity GO:0051341 46 24 2,000 8,003E-04 9,439E-03 ! regulation of T cell activation GO:0050863 158 94 4,000 8,015E-04 9,407E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 8,61E-04 0,0100561 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 1,000 8,61E-04 0,01000752 ! embryonic hemopoiesis GO:0035162 14 6 1,000 8,61E-04 9,959E-03 ! thymic T cell selection GO:0045061 12 6 1,000 8,61E-04 9,912E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 8,61E-04 9,865E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 8,61E-04 9,818E-03 ! establishment of spindle localization GO:0051293 12 6 1,000 8,61E-04 9,771E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 8,61E-04 9,726E-03 GO:0045686|negative regulation of glial cell differentiation, ! regulation of interleukin-13 production GO:0032656 11 6 1,000 8,61E-04 9,68E-03 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 8,61E-04 9,635E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 8,61E-04 9,591E-03 GO:0043011|myeloid dendritic cell differentiation, ! negative regulation of B cell activation GO:0050869 13 6 1,000 8,61E-04 9,546E-03 ! leukocyte differentiation GO:0002521 202 96 4,000 8,816E-04 9,73E-03 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 2,000 9,043E-04 9,935E-03 ! vasculogenesis GO:0001570 46 25 2,000 9,043E-04 9,89E-03 ! somitogenesis GO:0001756 43 25 2,000 9,043E-04 9,845E-03 ! insulin receptor signaling pathway GO:0008286 64 26 2,000 1,016E-03 0,01101646 ! regulation of endothelial cell proliferation GO:0001936 57 26 2,000 1,016E-03 0,01096705 ! cellular response to oxidative stress GO:0034599 39 26 2,000 1,016E-03 0,01091809 ! blastocyst development GO:0001824 49 26 2,000 1,016E-03 0,01086957 ! skeletal system morphogenesis GO:0048705 105 59 3,000 1,103E-03 0,0117406 ! DNA catabolic process GO:0006308 86 59 3,000 1,103E-03 0,01168888 ! integrin-mediated signaling pathway GO:0007229 135 59 3,000 1,103E-03 0,01163762 ! regulation of chromosome organization GO:0033044 42 27 2,000 1,137E-03 0,01194701 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 1,137E-03 0,01189507 ! negative regulation of response to stimulus GO:0048585 100 60 3,000 1,175E-03 0,01223368 ! cytokinesis during cell cycle GO:0033205 11 7 1,000 1,199E-03 0,01243756 ! prostate gland development GO:0030850 13 7 1,000 1,199E-03 0,01238418 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,199E-03 0,01233125 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 1,199E-03 0,01227878 ! mRNA stabilization GO:0048255 18 7 1,000 1,199E-03 0,01222675 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 10 7 1,000 1,199E-03 0,01217516 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,199E-03 0,01212401 ! positive regulation of isotype switching GO:0045830 15 7 1,000 1,199E-03 0,01207328 GO:0045911|positive regulation of DNA recombination, ! organ growth GO:0035265 15 7 1,000 1,199E-03 0,01202297 ! B cell lineage commitment GO:0002326 21 7 1,000 1,199E-03 0,01197309 ! cranial nerve morphogenesis GO:0021602 11 7 1,000 1,199E-03 0,01192361 ! regulation of interleukin-10 production GO:0032653 13 7 1,000 1,199E-03 0,01187454 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 1,199E-03 0,01182588 ! T cell lineage commitment GO:0002360 16 7 1,000 1,199E-03 0,01177761 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 1,000 1,199E-03 0,01172973 GO:0002714|positive regulation of B cell mediated immunity, ! oxygen homeostasis GO:0032364 12 7 1,000 1,199E-03 0,01168224 ! peptidyl-threonine modification GO:0018210 25 7 1,000 1,199E-03 0,01163514 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 1,000 1,199E-03 0,01158841 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 1,199E-03 0,01154205 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 1,000 1,199E-03 0,01149607 ! response to peptide hormone stimulus GO:0043434 122 61 3,000 1,249E-03 0,01192975 ! cellular iron ion homeostasis GO:0006879 51 29 2,000 1,405E-03 0,01335717 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 1,405E-03 0,01330458 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 2,000 1,405E-03 0,01325241 ! steroid hormone receptor signaling pathway GO:0030518 129 63 3,000 1,409E-03 0,01324529 ! cell junction assembly GO:0034329 78 30 2,000 1,552E-03 0,01452812 ! positive regulation of multicellular organism growth GO:0040018 51 30 2,000 1,552E-03 0,01447181 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 1,552E-03 0,01441594 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 1,591E-03 0,01472272 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 1,591E-03 0,01466631 ! succinate metabolic process GO:0006105 14 8 1,000 1,591E-03 0,01461033 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,591E-03 0,01455478 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,591E-03 0,01449965 ! hemoglobin metabolic process GO:0020027 13 8 1,000 1,591E-03 0,01444493 ! pigment granule organization GO:0048753 16 8 1,000 1,591E-03 0,01439063 ! ER overload response GO:0006983 12 8 1,000 1,591E-03 0,01433673 ! regulation of pigmentation during development GO:0048070 24 8 1,000 1,591E-03 0,01428324 ! melanin metabolic process GO:0006582 15 8 1,000 1,591E-03 0,01423014 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,591E-03 0,01417743 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,591E-03 0,01412512 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 1,591E-03 0,01407319 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,591E-03 0,01402164 ! response to UV-B GO:0010224 16 8 1,000 1,591E-03 0,01397046 ! regulation of interleukin-4 production GO:0032673 17 8 1,000 1,591E-03 0,01391966 ! trophectodermal cell differentiation GO:0001829 13 8 1,000 1,591E-03 0,01386923 ! B cell receptor signaling pathway GO:0050853 16 8 1,000 1,591E-03 0,01381916 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 1,000 1,591E-03 0,01376945 ! iron ion homeostasis GO:0055072 54 31 2,000 1,708E-03 0,01473307 ! myeloid leukocyte activation GO:0002274 49 31 2,000 1,708E-03 0,01468045 ! cellular hormone metabolic process GO:0034754 113 67 3,000 1,771E-03 0,0151613 ! negative regulation of cell growth GO:0030308 132 67 3,000 1,771E-03 0,01510754 ! activation of MAPK activity GO:0000187 115 67 3,000 1,771E-03 0,01505416 ! lung development GO:0030324 144 67 3,000 1,771E-03 0,01500115 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 3,000 1,87E-03 0,01578844 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 1,875E-03 0,01577013 ! hindbrain development GO:0030902 61 32 2,000 1,875E-03 0,01571518 ! negative regulation of cell size GO:0045792 134 69 3,000 1,973E-03 0,01648695 ! autophagic vacuole formation GO:0000045 15 9 1,000 2,035E-03 0,01694373 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 2,035E-03 0,0168853 ! regulation of glycolysis GO:0006110 21 9 1,000 2,035E-03 0,01682728 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 2,035E-03 0,01676965 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 2,035E-03 0,01671241 ! induction of an organ GO:0001759 14 9 1,000 2,035E-03 0,01665557 ! synaptic vesicle endocytosis GO:0048488 20 9 1,000 2,035E-03 0,01659911 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 1,000 2,035E-03 0,01654303 GO:0002820|negative regulation of adaptive immune response, ! regulation of telomere maintenance GO:0032204 14 9 1,000 2,035E-03 0,01648733 ! microtubule bundle formation GO:0001578 21 9 1,000 2,035E-03 0,016432 ! middle ear morphogenesis GO:0042474 14 9 1,000 2,035E-03 0,01637705 ! phosphagen metabolic process GO:0006599 12 9 1,000 2,035E-03 0,01632246 GO:0006600|creatine metabolic process, ! behavioral fear response GO:0001662 22 9 1,000 2,035E-03 0,01626823 GO:0002209|behavioral defense response, ! gas homeostasis GO:0033483 16 9 1,000 2,035E-03 0,01621436 ! leukocyte chemotaxis GO:0030595 50 33 2,000 2,05E-03 0,01628187 GO:0060326|cell chemotaxis, ! respiratory tube development GO:0030323 150 70 3,000 2,081E-03 0,01646747 ! respiratory system development GO:0060541 153 72 3,000 2,307E-03 0,01819855 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 2,000 2,432E-03 0,01912358 ! telencephalon development GO:0021537 68 35 2,000 2,432E-03 0,01906129 ! regulation of microtubule-based process GO:0032886 78 35 2,000 2,432E-03 0,0189994 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 1,000 2,531E-03 0,01970882 ! lung alveolus development GO:0048286 26 10 1,000 2,531E-03 0,01964524 ! B cell proliferation GO:0042100 18 10 1,000 2,531E-03 0,01958207 ! macroautophagy GO:0016236 17 10 1,000 2,531E-03 0,01951931 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 1,000 2,531E-03 0,01945695 ! regulation of bone resorption GO:0045124 25 10 1,000 2,531E-03 0,01939498 ! regulation of gliogenesis GO:0014013 23 10 1,000 2,531E-03 0,01933341 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell activation GO:0046631 23 10 1,000 2,531E-03 0,01927223 ! regulation of B cell differentiation GO:0045577 19 10 1,000 2,531E-03 0,01921144 ! apical protein localization GO:0045176 15 10 1,000 2,531E-03 0,01915102 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 2,531E-03 0,01909099 GO:0043470|regulation of carbohydrate catabolic process, ! oocyte development GO:0048599 17 10 1,000 2,531E-03 0,01903133 ! response to nicotine GO:0035094 20 10 1,000 2,531E-03 0,01897204 ! negative regulation of immune effector process GO:0002698 20 10 1,000 2,531E-03 0,01891312 ! localization within membrane GO:0051668 20 10 1,000 2,531E-03 0,01885457 ! cell junction organization GO:0034330 86 36 2,000 2,638E-03 0,0195925 ! negative regulation of cell activation GO:0050866 65 36 2,000 2,638E-03 0,01953221 ! lymphocyte differentiation GO:0030098 167 75 3,000 2,677E-03 0,0197596 ! steroid biosynthetic process GO:0006694 131 76 3,000 2,809E-03 0,0206703 ! tissue remodeling GO:0048771 76 37 2,000 2,855E-03 0,02094307 ! cellular response to insulin stimulus GO:0032869 82 37 2,000 2,855E-03 0,02087941 ! detection of mechanical stimulus GO:0050982 22 11 1,000 3,078E-03 0,02244187 ! blood vessel remodeling GO:0001974 29 11 1,000 3,078E-03 0,02237407 ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 3,078E-03 0,02230667 ! negative regulation of ossification GO:0030279 26 11 1,000 3,078E-03 0,02223969 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 1,000 3,078E-03 0,0221731 ! positive regulation of T cell mediated immunity GO:0002711 24 11 1,000 3,078E-03 0,02210691 ! DNA methylation GO:0006306 19 11 1,000 3,078E-03 0,02204112 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 24 11 1,000 3,078E-03 0,02197571 ! regulation of isotype switching GO:0045191 22 11 1,000 3,078E-03 0,0219107 ! oocyte differentiation GO:0009994 18 11 1,000 3,078E-03 0,02184606 ! thymus development GO:0048538 27 11 1,000 3,078E-03 0,02178181 ! germ cell migration GO:0008354 25 11 1,000 3,078E-03 0,02171793 ! developmental induction GO:0031128 19 11 1,000 3,078E-03 0,02165443 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 23 11 1,000 3,078E-03 0,0215913 ! regulation of embryonic development GO:0045995 27 11 1,000 3,078E-03 0,02152853 ! nucleus organization GO:0006997 67 38 2,000 3,082E-03 0,02149652 ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 3,082E-03 0,02143439 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! negative regulation of organelle organization GO:0010639 161 78 3,000 3,087E-03 0,02140094 ! mammary gland development GO:0030879 86 39 2,000 3,321E-03 0,0229577 ! segmentation GO:0035282 67 39 2,000 3,321E-03 0,02289192 ! negative regulation of binding GO:0051100 72 40 2,000 3,57E-03 0,02453902 ! multicellular organismal metabolic process GO:0044236 57 40 2,000 3,57E-03 0,02446911 ! cytokinesis GO:0000910 72 40 2,000 3,57E-03 0,0243996 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 3,675E-03 0,02504866 ! cartilage condensation GO:0001502 20 12 1,000 3,675E-03 0,0249779 ! positive regulation of cell growth GO:0030307 22 12 1,000 3,675E-03 0,02490754 ! asymmetric protein localization GO:0008105 20 12 1,000 3,675E-03 0,02483757 ! membrane protein proteolysis GO:0033619 25 12 1,000 3,675E-03 0,024768 GO:0006509|membrane protein ectodomain proteolysis, ! fear response GO:0042596 26 12 1,000 3,675E-03 0,02469882 ! cranial nerve development GO:0021545 20 12 1,000 3,675E-03 0,02463002 ! histone acetylation GO:0016573 26 12 1,000 3,675E-03 0,0245616 ! histone methylation GO:0016571 26 12 1,000 3,675E-03 0,02449356 ! autonomic nervous system development GO:0048483 24 12 1,000 3,675E-03 0,0244259 ! gland morphogenesis GO:0022612 29 12 1,000 3,675E-03 0,02435861 ! regulation of hormone metabolic process GO:0032350 26 12 1,000 3,675E-03 0,02429169 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,675E-03 0,02422514 ! T cell homeostasis GO:0043029 25 12 1,000 3,675E-03 0,02415895 ! spleen development GO:0048536 22 12 1,000 3,675E-03 0,02409312 ! digestive tract morphogenesis GO:0048546 26 12 1,000 3,675E-03 0,02402765 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 3,675E-03 0,02396254 ! cellular response to hormone stimulus GO:0032870 167 82 3,000 3,696E-03 0,02403248 ! T cell differentiation GO:0030217 81 41 2,000 3,83E-03 0,02483773 ! response to reactive oxygen species GO:0000302 67 42 2,000 4,101E-03 0,02652704 ! negative regulation of protein complex disassembly GO:0043242 101 42 2,000 4,101E-03 0,02645592 ! regulation of myeloid cell differentiation GO:0045637 98 42 2,000 4,101E-03 0,02638518 ! one-carbon metabolic process GO:0006730 154 85 3,000 4,203E-03 0,02696571 ! regulation of chemokine production GO:0032642 18 13 1,000 4,321E-03 0,02765212 ! regulation of cell-cell adhesion GO:0022407 33 13 1,000 4,321E-03 0,02757877 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 1,000 4,321E-03 0,02750581 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 4,321E-03 0,02743323 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 4,321E-03 0,02736104 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 4,321E-03 0,02728923 ! regulation of DNA repair GO:0006282 21 13 1,000 4,321E-03 0,02721779 ! chromatin silencing GO:0006342 26 13 1,000 4,321E-03 0,02714672 ! regulation of mRNA stability GO:0043488 31 13 1,000 4,321E-03 0,02707603 ! mitochondrion organization GO:0007005 148 86 3,000 4,382E-03 0,02738364 ! biopolymer methylation GO:0043414 84 44 2,000 4,679E-03 0,02916398 ! B cell differentiation GO:0030183 107 44 2,000 4,679E-03 0,02908862 ! regulation of cell morphogenesis GO:0022604 215 89 3,000 4,949E-03 0,03069111 ! glycolysis GO:0006096 65 45 2,000 4,985E-03 0,03083271 ! leukocyte migration GO:0050900 68 45 2,000 4,985E-03 0,03075365 ! branching morphogenesis of a tube GO:0048754 97 45 2,000 4,985E-03 0,030675 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 5,016E-03 0,03078823 ! regulation of S phase GO:0033261 23 14 1,000 5,016E-03 0,03070988 ! hair follicle morphogenesis GO:0031069 26 14 1,000 5,016E-03 0,03063194 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 5,016E-03 0,03055439 GO:0060675|ureteric bud morphogenesis, ! response to gamma radiation GO:0010332 28 14 1,000 5,016E-03 0,03047723 ! regulation of RNA stability GO:0043487 32 14 1,000 5,016E-03 0,03040047 ! ossification GO:0001503 188 90 3,000 5,149E-03 0,03112664 ! response to insulin stimulus GO:0032868 95 46 2,000 5,303E-03 0,03197736 ! bone development GO:0060348 189 91 3,000 5,354E-03 0,03220365 ! positive regulation of defense response GO:0031349 76 47 2,000 5,633E-03 0,03379731 ! endosome transport GO:0016197 108 47 2,000 5,633E-03 0,03371324 ! methylation GO:0032259 90 47 2,000 5,633E-03 0,03362959 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 5,759E-03 0,03429623 ! positive regulation of cell size GO:0045793 27 15 1,000 5,759E-03 0,03421155 ! regulation of T cell mediated immunity GO:0002709 33 15 1,000 5,759E-03 0,03412728 ! histone deacetylation GO:0016575 20 15 1,000 5,759E-03 0,03404343 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 5,759E-03 0,03395999 ! muscle maintenance GO:0046716 26 15 1,000 5,759E-03 0,03387696 ! regulation of T-helper cell differentiation GO:0045622 26 15 1,000 5,759E-03 0,03379434 ! lymphocyte homeostasis GO:0002260 30 15 1,000 5,759E-03 0,03371211 ! positive regulation of cell cycle GO:0045787 89 48 2,000 5,975E-03 0,03489192 ! Notch signaling pathway GO:0007219 96 48 2,000 5,975E-03 0,03480743 ! cellular component disassembly GO:0022411 86 48 2,000 5,975E-03 0,03472336 ! activation of caspase activity GO:0006919 84 48 2,000 5,975E-03 0,03463969 ! regulation of inflammatory response GO:0050727 75 48 2,000 5,975E-03 0,03455642 ! regulation of protein complex disassembly GO:0043244 113 49 2,000 6,329E-03 0,03651674 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 6,329E-03 0,03642937 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 6,548E-03 0,03760245 ! startle response GO:0001964 28 16 1,000 6,548E-03 0,03751292 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 1,000 6,548E-03 0,03742382 ! protein polyubiquitination GO:0000209 34 16 1,000 6,548E-03 0,03733514 ! negative regulation of immune response GO:0050777 35 16 1,000 6,548E-03 0,03724687 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 1,000 6,548E-03 0,03715903 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 1,000 6,548E-03 0,0370716 ! inner ear development GO:0048839 79 50 2,000 6,695E-03 0,03781457 ! regulation of gene expression, epigenetic GO:0040029 105 50 2,000 6,695E-03 0,03772601 ! hormone metabolic process GO:0042445 157 97 3,000 6,699E-03 0,03765642 ! response to virus GO:0009615 160 98 3,000 6,943E-03 0,03893643 ! chromatin remodeling GO:0006338 109 51 2,000 7,074E-03 0,0395821 ! positive regulation of cell killing GO:0031343 32 17 1,000 7,384E-03 0,04122137 ! metencephalon development GO:0022037 30 17 1,000 7,384E-03 0,04112595 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 7,384E-03 0,04103098 ! heart looping GO:0001947 30 17 1,000 7,384E-03 0,04093643 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 1,000 7,384E-03 0,04084233 ! regulation of viral genome replication GO:0045069 28 17 1,000 7,384E-03 0,04074865 ! regulation of survival gene product expression GO:0045884 33 17 1,000 7,384E-03 0,04065541 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 7,384E-03 0,04056259 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 1,000 7,384E-03 0,04047019 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 1,000 7,384E-03 0,04037821 ! branched chain family amino acid metabolic process GO:0009081 33 17 1,000 7,384E-03 0,04028665 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 1,000 7,384E-03 0,0401955 ! cell cycle arrest GO:0007050 213 100 3,000 7,448E-03 0,04044984 ! regulation of angiogenesis GO:0045765 114 52 2,000 7,465E-03 0,04045406 ! regulation of muscle contraction GO:0006937 81 52 2,000 7,465E-03 0,04036315 ! morphogenesis of a branching structure GO:0001763 111 52 2,000 7,465E-03 0,04027265 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 8,266E-03 0,04448955 ! protein amino acid ADP-ribosylation GO:0006471 33 18 1,000 8,266E-03 0,04439024 ! patterning of blood vessels GO:0001569 39 18 1,000 8,266E-03 0,04429138 ! epidermis morphogenesis GO:0048730 40 18 1,000 8,266E-03 0,04419295 ! regulation of immunoglobulin production GO:0002637 43 18 1,000 8,266E-03 0,04409496 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 8,266E-03 0,04399741 ! nerve development GO:0021675 28 18 1,000 8,266E-03 0,04390028 ! negative regulation of cytoskeleton organization GO:0051494 124 54 2,000 8,286E-03 0,04390991 ! positive regulation of caspase activity GO:0043280 95 55 2,000 8,715E-03 0,04608289 GO:0010952|positive regulation of peptidase activity, ! glucose catabolic process GO:0006007 82 55 2,000 8,715E-03 0,04598183 ! aging GO:0007568 103 55 2,000 8,715E-03 0,04588121 ! regulation of multicellular organism growth GO:0040014 85 55 2,000 8,715E-03 0,04578104 ! regulation of DNA replication GO:0006275 101 56 2,000 9,157E-03 0,04799819 ! positive regulation of angiogenesis GO:0045766 44 19 1,000 9,192E-03 0,04807585 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 1,000 9,192E-03 0,04797156 ! lipid phosphorylation GO:0046834 35 19 1,000 9,192E-03 0,04786773 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 9,192E-03 0,04776434 ! actin filament bundle formation GO:0051017 42 19 1,000 9,192E-03 0,0476614 ! neuromuscular junction development GO:0007528 34 19 1,000 9,192E-03 0,04755891 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 9,192E-03 0,04745685 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 1,000 9,192E-03 0,04735523 ! regulation of bone remodeling GO:0046850 137 57 2,000 9,612E-03 0,04941378 ! regulation of tissue remodeling GO:0034103 140 58 2,000 0,01007952 0,05170857 ! protein amino acid deacetylation GO:0006476 29 20 1,000 0,01016161 0,05201881 ! protein amino acid acetylation GO:0006473 39 20 1,000 0,01016161 0,05190837 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 0,01016161 0,0517984 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 0,01016161 0,05168888 GO:0010675|regulation of cellular carbohydrate metabolic process, ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 1,000 0,01016161 0,05157984 ! cellular response to starvation GO:0009267 33 20 1,000 0,01016161 0,05147125 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 0,01016161 0,05136311 ! fatty acid beta-oxidation GO:0006635 34 20 1,000 0,01016161 0,05125544 ! regulation of interleukin-2 production GO:0032663 35 20 1,000 0,01016161 0,05114821 ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 1,000 0,01016161 0,05104143 ! actin filament-based movement GO:0030048 43 20 1,000 0,01016161 0,05093509 ! negative regulation of translation GO:0017148 29 20 1,000 0,01016161 0,05082919 ! regulation of heart contraction GO:0008016 110 60 2,000 0,01105441 0,05518029 ! protein amino acid autophosphorylation GO:0046777 141 60 2,000 0,01105441 0,05506604 ! regulation of cell killing GO:0031341 42 21 1,000 0,01117495 0,05555153 ! ovarian follicle development GO:0001541 35 21 1,000 0,01117495 0,05543699 ! cell aging GO:0007569 44 21 1,000 0,01117495 0,05532292 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 1,000 0,01117495 0,05520932 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 0,01117495 0,05509619 ! oogenesis GO:0048477 36 21 1,000 0,01117495 0,05498352 ! DNA modification GO:0006304 34 21 1,000 0,01117495 0,05487131 ! gut development GO:0048565 39 21 1,000 0,01117495 0,05475955 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 1,000 0,01223087 0,05981192 ! regeneration GO:0031099 41 22 1,000 0,01223087 0,0596906 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 0,01223087 0,05956976 ! ureteric bud development GO:0001657 43 22 1,000 0,01223087 0,05944942 ! renal system process GO:0003014 41 22 1,000 0,01223087 0,05932956 ! positive regulation of adaptive immune response GO:0002821 39 22 1,000 0,01223087 0,05921019 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 0,01223087 0,05909129 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 0,01223087 0,05897287 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 0,01223087 0,05885493 ! protein stabilization GO:0050821 39 22 1,000 0,01223087 0,05873745 ! multicellular organism reproduction GO:0032504 111 64 2,000 0,0131625 0,06308559 GO:0048609|reproductive process in a multicellular organism, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 1,000 0,01332864 0,0637549 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 0,01332864 0,0636284 ! myeloid leukocyte differentiation GO:0002573 40 23 1,000 0,01332864 0,0635024 ! gluconeogenesis GO:0006094 33 23 1,000 0,01332864 0,0633769 ! leukocyte adhesion GO:0007159 50 23 1,000 0,01332864 0,0632519 ! regulation of DNA recombination GO:0000018 48 23 1,000 0,01332864 0,06312739 ! response to ethanol GO:0045471 46 23 1,000 0,01332864 0,06300336 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 1,000 0,01332864 0,06287983 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of viral reproduction GO:0050792 38 23 1,000 0,01332864 0,06275678 ! synaptic vesicle transport GO:0048489 46 23 1,000 0,01332864 0,0626342 ! germ cell development GO:0007281 118 65 2,000 0,0137228 0,06436074 ! actin filament organization GO:0007015 148 66 2,000 0,01429651 0,06692101 ! fatty acid biosynthetic process GO:0006633 124 66 2,000 0,01429651 0,06679107 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 0,01446758 0,06745931 ! regulation of cellular catabolic process GO:0031329 52 24 1,000 0,01446758 0,06732883 ! multicellular organismal response to stress GO:0033555 49 24 1,000 0,01446758 0,06719885 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 1,000 0,01446758 0,06706938 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukocyte homeostasis GO:0001776 44 24 1,000 0,01446758 0,0669404 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 0,01446758 0,06681191 ! hexose catabolic process GO:0019320 104 67 2,000 0,01488366 0,06860168 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 1,000 0,015647 0,07198219 ! myelination GO:0042552 45 25 1,000 0,015647 0,07184482 ! dicarboxylic acid metabolic process GO:0043648 42 25 1,000 0,015647 0,07170797 ! protein amino acid alkylation GO:0008213 53 25 1,000 0,015647 0,07157164 GO:0006479|protein amino acid methylation, ! negative regulation of DNA replication GO:0008156 42 25 1,000 0,015647 0,07143583 ! response to starvation GO:0042594 42 25 1,000 0,015647 0,07130054 ! response to endoplasmic reticulum stress GO:0034976 43 25 1,000 0,015647 0,07116575 ! neural crest cell development GO:0014032 54 25 1,000 0,015647 0,07103148 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 73 25 1,000 0,015647 0,07089771 GO:0050768|negative regulation of neurogenesis, ! immunoglobulin production GO:0002377 55 25 1,000 0,015647 0,07076444 GO:0002440|production of molecular mediator of immune response, ! cellular response to nutrient levels GO:0031669 41 25 1,000 0,015647 0,07063168 ! urogenital system development GO:0001655 137 69 2,000 0,0160984 0,07253326 ! initiation of viral infection GO:0019059 57 26 1,000 0,01686621 0,07585066 ! pyruvate metabolic process GO:0006090 38 26 1,000 0,01686621 0,07570915 ! molting cycle process GO:0022404 50 26 1,000 0,01686621 0,07556816 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 48 26 1,000 0,01686621 0,0754277 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 0,01686621 0,07528776 ! positive regulation of MAPKKK cascade GO:0043410 47 26 1,000 0,01686621 0,07514834 ! positive regulation of nuclear division GO:0051785 40 26 1,000 0,01686621 0,07500943 GO:0045840|positive regulation of mitosis, ! reproductive structure development GO:0048608 113 71 2,000 0,01736728 0,07709534 ! B cell activation GO:0042113 160 71 2,000 0,01736728 0,07695336 ! regulation of caspase activity GO:0043281 122 72 2,000 0,01802208 0,07970793 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 0,01812454 0,08001402 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01812454 0,07986748 ! mitochondrial membrane organization GO:0007006 57 27 1,000 0,01812454 0,07972147 ! male gonad development GO:0008584 44 27 1,000 0,01812454 0,07957599 ! regulation of fibroblast proliferation GO:0048145 52 27 1,000 0,01812454 0,07943104 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 0,01812454 0,07928662 ! autophagy GO:0006914 41 27 1,000 0,01812454 0,07914272 ! response to toxin GO:0009636 47 27 1,000 0,01812454 0,07899935 ! negative regulation of neuron differentiation GO:0045665 42 27 1,000 0,01812454 0,07885649 ! axon guidance GO:0007411 139 73 2,000 0,01869047 0,08117197 ! regulation of transcription factor activity GO:0051090 126 74 2,000 0,01937248 0,0839823 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 121 74 2,000 0,01937248 0,08383126 GO:0051327|M phase of meiotic cell cycle, ! regulation of endopeptidase activity GO:0052548 125 74 2,000 0,01937248 0,08368075 ! ER-nuclear signaling pathway GO:0006984 48 28 1,000 0,01942132 0,08374139 ! positive regulation of T cell differentiation GO:0045582 42 28 1,000 0,01942132 0,08359159 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 0,01942132 0,08344232 ! lipid oxidation GO:0034440 43 28 1,000 0,01942132 0,08329358 GO:0019395|fatty acid oxidation, ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 2,000 0,02006811 0,08591436 ! meiotic cell cycle GO:0051321 122 75 2,000 0,02006811 0,08576175 ! immune response-activating signal transduction GO:0002757 47 29 1,000 0,0207559 0,08854377 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 1,000 0,0207559 0,08838705 ! response to organic cyclic substance GO:0014070 55 29 1,000 0,0207559 0,08823089 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 0,0207559 0,08807528 ! tissue homeostasis GO:0001894 48 29 1,000 0,0207559 0,08792022 GO:0048871|multicellular organismal homeostasis, ! cytosolic calcium ion homeostasis GO:0051480 135 76 2,000 0,02077737 0,08785652 ! monosaccharide catabolic process GO:0046365 115 76 2,000 0,02077737 0,08770239 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 0,02150028 0,09059488 ! ensheathment of neurons GO:0007272 57 30 1,000 0,02212761 0,09307524 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 0,02212761 0,09291281 ! regulation of peptidase activity GO:0052547 134 79 2,000 0,02298703 0,09635329 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 1,000 0,02353583 0,09848211 ! collagen metabolic process GO:0032963 45 31 1,000 0,02353583 0,09831113 ! ovulation cycle process GO:0022602 49 31 1,000 0,02353583 0,09814075 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,02353583 0,09797095 ! mesoderm formation GO:0001707 69 31 1,000 0,02353583 0,09780175 ! fatty acid catabolic process GO:0009062 48 31 1,000 0,02353583 0,09763312 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 0,02353583 0,09746508 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 67 31 1,000 0,02353583 0,09729761 ! regulation of neuron differentiation GO:0045664 167 81 2,000 0,02452835 0,10122676 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,02497991 0,10291383 ! spindle organization GO:0007051 46 32 1,000 0,02497991 0,10273791 ! metanephros development GO:0001656 74 32 1,000 0,02497991 0,10256259 ! response to ionizing radiation GO:0010212 65 32 1,000 0,02497991 0,10238786 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,02497991 0,10221373 ! hexose biosynthetic process GO:0019319 48 32 1,000 0,02497991 0,1020402 ! ovulation cycle GO:0042698 51 32 1,000 0,02497991 0,10186725 ! peripheral nervous system development GO:0007422 64 32 1,000 0,02497991 0,10169488 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,02497991 0,1015231 ! positive regulation of catabolic process GO:0009896 64 32 1,000 0,02497991 0,1013519 ! gene silencing GO:0016458 65 32 1,000 0,02497991 0,10118127 ! response to drug GO:0042493 143 82 2,000 0,02531946 0,10238423 ! post-embryonic development GO:0009791 69 33 1,000 0,02645923 0,10681362 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,02645923 0,1066347 ! formation of primary germ layer GO:0001704 72 33 1,000 0,02645923 0,10645639 ! cell fate specification GO:0001708 52 33 1,000 0,02645923 0,10627866 ! adult locomotory behavior GO:0008344 59 33 1,000 0,02645923 0,10610153 ! negative regulation of transport GO:0051051 153 84 2,000 0,02694253 0,10785979 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,02777447 0,11100561 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 1,000 0,02797317 0,11161434 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 1,000 0,02797317 0,11142955 ! mesoderm morphogenesis GO:0048332 76 34 1,000 0,02797317 0,11124537 ! tube morphogenesis GO:0035239 176 86 2,000 0,02861999 0,11362985 ! alcohol catabolic process GO:0046164 130 86 2,000 0,02861999 0,11344265 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,02952111 0,11682202 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 0,02952111 0,1166302 ! odontogenesis GO:0042476 66 35 1,000 0,02952111 0,116439 ! embryonic skeletal system morphogenesis GO:0048704 59 35 1,000 0,02952111 0,11624843 ! female gonad development GO:0008585 58 35 1,000 0,02952111 0,11605848 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,02952111 0,11586915 ! regulation of DNA binding GO:0051101 155 88 2,000 0,03035168 0,11893508 ! regulation of neurological system process GO:0031644 148 88 2,000 0,03035168 0,11874169 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,03110245 0,12148131 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 1,000 0,03110245 0,12128442 ! positive regulation of cell development GO:0010720 80 36 1,000 0,03110245 0,12108816 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 1,000 0,03110245 0,12089254 ! embryonic organ development GO:0048568 57 36 1,000 0,03110245 0,12069756 ! monosaccharide biosynthetic process GO:0046364 52 36 1,000 0,03110245 0,1205032 ! sex differentiation GO:0007548 145 90 2,000 0,03213742 0,12431292 ! meiosis I GO:0007127 65 37 1,000 0,03271658 0,12635007 ! sister chromatid segregation GO:0000819 58 37 1,000 0,03271658 0,12614759 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,03271658 0,12594575 ! glycogen metabolic process GO:0005977 61 37 1,000 0,03271658 0,12574456 ! pigment metabolic process GO:0042440 80 37 1,000 0,03271658 0,12554401 ! regulation of defense response GO:0031347 149 92 2,000 0,033977 0,13017303 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,03436292 0,13144228 ! carbohydrate homeostasis GO:0033500 53 38 1,000 0,03436292 0,13123364 GO:0042593|glucose homeostasis, ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,03436292 0,13102566 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 62 38 1,000 0,03436292 0,13081835 GO:0006073|cellular glucan metabolic process, ! regulation of membrane potential GO:0042391 164 93 2,000 0,0349169 0,13271732 ! negative regulation of multicellular organismal process GO:0051241 166 93 2,000 0,0349169 0,13250799 ! female pregnancy GO:0007565 164 94 2,000 0,03587017 0,13591121 ! learning GO:0007612 77 39 1,000 0,03604089 0,13634336 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,03604089 0,13612932 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 1,000 0,03604089 0,13591595 ! ear morphogenesis GO:0042471 60 39 1,000 0,03604089 0,13570325 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,03604089 0,13549122 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 1,000 0,0377499 0,14169463 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,0377691 0,14154586 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,0377691 0,14132573 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,0377691 0,14110628 ! neuron fate determination GO:0048664 7 5 0,000 0,0377691 0,14088751 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0377691 0,14066942 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,0377691 0,140452 ! polyol transport GO:0015791 12 5 0,000 0,0377691 0,14023525 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,0377691 0,14001917 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,0377691 0,13980376 ! response to superoxide GO:0000303 10 5 0,000 0,0377691 0,13958901 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,0377691 0,13937491 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,0377691 0,13916148 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,0377691 0,13894869 ! female meiosis GO:0007143 7 5 0,000 0,0377691 0,13873656 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0377691 0,13852507 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,0377691 0,13831422 ! cobalt ion transport GO:0006824 11 5 0,000 0,0377691 0,13810402 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,0377691 0,13789445 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,0377691 0,13768552 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,0377691 0,13747722 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,0377691 0,13726955 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,0377691 0,13706251 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,0377691 0,13685609 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,0377691 0,13665029 GO:0006451|translational readthrough, ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,0377691 0,13644511 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0377691 0,13624055 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0377691 0,13603659 ! negative chemotaxis GO:0050919 14 5 0,000 0,0377691 0,13583325 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0377691 0,13563051 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,0377691 0,13542838 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,0377691 0,13522685 ! behavioral response to pain GO:0048266 9 5 0,000 0,0377691 0,13502592 ! clathrin coat assembly GO:0048268 14 5 0,000 0,0377691 0,13482559 ! Notch receptor processing GO:0007220 8 5 0,000 0,0377691 0,13462584 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0377691 0,13442669 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0377691 0,13422813 ! micturition GO:0060073 9 5 0,000 0,0377691 0,13403015 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,0377691 0,13383276 ! copulation GO:0007620 9 5 0,000 0,0377691 0,13363595 ! glial cell fate commitment GO:0021781 13 5 0,000 0,0377691 0,13343971 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,0377691 0,13324405 ! spermidine metabolic process GO:0008216 7 5 0,000 0,0377691 0,13304897 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,0377691 0,13285445 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,0377691 0,1326605 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,0377691 0,13246712 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,0377691 0,1322743 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,0377691 0,13208204 ! grooming behavior GO:0007625 6 5 0,000 0,0377691 0,13189034 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,0377691 0,1316992 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,0377691 0,1315086 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0377691 0,13131856 ! response to protozoan GO:0001562 10 5 0,000 0,0377691 0,13112907 ! lymph vessel development GO:0001945 10 5 0,000 0,0377691 0,13094012 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,0377691 0,13075172 ! endochondral ossification GO:0001958 16 5 0,000 0,0377691 0,13056386 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,0377691 0,13037653 ! parathyroid gland development GO:0060017 13 5 0,000 0,0377691 0,13018975 ! anagen GO:0042640 6 5 0,000 0,0377691 0,1300035 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,0377691 0,12981778 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,0377691 0,12963259 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,0377691 0,12944793 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,0377691 0,12926379 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,0377691 0,12908018 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,0377691 0,12889708 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,0377691 0,12871451 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,0377691 0,12853245 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,0377691 0,12835091 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,0377691 0,12816988 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,0377691 0,12798936 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,0377691 0,12780935 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,0377691 0,12762984 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,0377691 0,12745083 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,0377691 0,12727233 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,0377691 0,12709433 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,0377691 0,12691682 ! histidine catabolic process GO:0006548 6 5 0,000 0,0377691 0,12673981 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,0377691 0,12656329 ! microvillus organization GO:0032528 7 5 0,000 0,0377691 0,12638727 GO:0030033|microvillus assembly, ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,0377691 0,12621173 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0377691 0,12603668 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,0377691 0,12586211 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,0377691 0,12568803 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0377691 0,12551443 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,0377691 0,1253413 ! polyol catabolic process GO:0046174 7 5 0,000 0,0377691 0,12516866 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0377691 0,12499648 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0377691 0,12482479 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0377691 0,12465356 ! muscle cell migration GO:0014812 8 5 0,000 0,0377691 0,1244828 ! mitochondrial fission GO:0000266 8 5 0,000 0,0377691 0,12431251 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,0377691 0,12414268 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,0377691 0,12397332 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,0377691 0,12380442 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,0377691 0,12363598 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0377691 0,123468 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,0377691 0,12330047 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,0377691 0,12313339 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,0377691 0,12296677 ! response to food GO:0032094 6 5 0,000 0,0377691 0,1228006 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,0377691 0,12263488 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,0377691 0,1224696 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0377691 0,12230477 ! forebrain neuron development GO:0021884 13 5 0,000 0,0377691 0,12214038 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,0377691 0,12197644 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,0377691 0,12181293 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,0377691 0,12164986 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0377691 0,12148723 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,0377691 0,12132503 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0377691 0,12116326 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,0377691 0,12100192 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,0377691 0,12084102 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,0377691 0,12068054 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,0377691 0,12052048 ! basic amino acid transport GO:0015802 11 5 0,000 0,0377691 0,12036085 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,0377691 0,12020165 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,0377691 0,12004286 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0377691 0,11988449 ! depyrimidination GO:0045008 10 5 0,000 0,0377691 0,11972654 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,0377691 0,11956901 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0377691 0,11941189 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,0377691 0,11925518 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,0377691 0,11909888 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0377691 0,11894299 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,0377691 0,11878751 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,0377691 0,11863243 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,0377691 0,11847776 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,0377691 0,1183235 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,0377691 0,11816963 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0377691 0,11801616 ! response to arsenic GO:0046685 10 5 0,000 0,0377691 0,11786309 ! mast cell degranulation GO:0043303 7 5 0,000 0,0377691 0,11771042 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,0377691 0,11755814 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,0377691 0,11740626 ! response to cadmium ion GO:0046686 7 5 0,000 0,0377691 0,11725477 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,0377691 0,11710367 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,0377691 0,11695295 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,0377691 0,11680263 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,0377691 0,11665269 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,0377691 0,11650313 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0377691 0,11635396 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0377691 0,11620517 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,0377691 0,11605676 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0377691 0,11590873 ! neural tube patterning GO:0021532 7 5 0,000 0,0377691 0,11576108 ! embryonic cleavage GO:0040016 6 5 0,000 0,0377691 0,1156138 ! peroxisome fission GO:0016559 5 5 0,000 0,0377691 0,11546689 ! histone demethylation GO:0016577 10 5 0,000 0,0377691 0,11532036 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,0377691 0,1151742 ! mitotic recombination GO:0006312 9 5 0,000 0,0377691 0,11502841 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,0377691 0,11488299 ! metaphase plate congression GO:0051310 7 5 0,000 0,0377691 0,11473794 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0377691 0,11459325 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,0377691 0,11444892 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,0377691 0,11430496 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,0377691 0,11416136 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,0377691 0,11401812 ! muscle cell proliferation GO:0033002 11 5 0,000 0,0377691 0,11387524 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,0377691 0,11373272 ! plasminogen activation GO:0031639 5 5 0,000 0,0377691 0,11359056 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,0377691 0,11344874 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,0377691 0,11330729 ! metaphase GO:0051323 8 5 0,000 0,0377691 0,11316618 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,0377691 0,11302543 ! cellular response to nutrient GO:0031670 8 5 0,000 0,0377691 0,11288502 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,0377691 0,11274497 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0377691 0,11260526 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0377691 0,1124659 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,0377691 0,11232688 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,0377691 0,1121882 ! response to redox state GO:0051775 5 5 0,000 0,0377691 0,11204987 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,0377691 0,11191188 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,0377691 0,11177422 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,0377691 0,11163691 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,0377691 0,11149993 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0377691 0,11136329 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,0377691 0,11122698 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0377691 0,11109101 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,0377691 0,11095537 ! striatum development GO:0021756 9 5 0,000 0,0377691 0,11082005 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,0377691 0,11068507 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,0377691 0,11055042 ! glial cell migration GO:0008347 11 5 0,000 0,0377691 0,11041609 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,0377691 0,11028209 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0377691 0,11014842 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,0377691 0,11001507 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,0377691 0,10988204 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,0377691 0,10974933 ! neuroprotection GO:0043526 6 5 0,000 0,0377691 0,10961694 ! neural plate development GO:0001840 8 5 0,000 0,0377691 0,10948487 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,0377691 0,10935312 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,0377691 0,10922169 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,0377691 0,10909057 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,0377691 0,10895977 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,0377691 0,10882927 ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,0377691 0,1086991 ! spindle assembly GO:0051225 6 5 0,000 0,0377691 0,10856923 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,0377691 0,10843967 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,0377691 0,10831042 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,0377691 0,10818148 ! drug metabolic process GO:0017144 6 5 0,000 0,0377691 0,10805285 ! phospholipid scrambling GO:0017121 8 5 0,000 0,0377691 0,10792452 ! organ regeneration GO:0031100 7 5 0,000 0,0377691 0,10779649 ! carnitine metabolic process GO:0009437 7 5 0,000 0,0377691 0,10766877 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,0377691 0,10754135 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,0377691 0,10741424 ! regulation of protein localization GO:0032880 176 97 2,000 0,03880976 0,11024355 ! cellular amide metabolic process GO:0043603 67 41 1,000 0,03948939 0,11204182 ! female gamete generation GO:0007292 61 41 1,000 0,03948939 0,11190985 ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 0,03948939 0,11177819 ! skeletal muscle tissue development GO:0007519 186 99 2,000 0,04083559 0,11545292 GO:0060538|skeletal muscle organ development, ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,04125878 0,11651248 GO:0090047|positive regulation of transcription regulator activity, ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 1,000 0,04125878 0,11637589 ! alcohol biosynthetic process GO:0046165 59 42 1,000 0,04125878 0,11623962 ! regulation of intracellular protein transport GO:0033157 80 42 1,000 0,04125878 0,11610366 ! regulation of leukocyte mediated immunity GO:0002703 79 42 1,000 0,04125878 0,11596803 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,04305754 0,12088265 ! glucose transport GO:0015758 65 43 1,000 0,04305754 0,12074176 ! hexose transport GO:0008645 67 44 1,000 0,04488509 0,12572006 GO:0015749|monosaccharide transport, ! male sex differentiation GO:0046661 76 44 1,000 0,04488509 0,12557387 ! double-strand break repair GO:0006302 81 44 1,000 0,04488509 0,12542803 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 1,000 0,04488509 0,12528252 ! developmental growth GO:0048589 82 44 1,000 0,04488509 0,12513735 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04515072 0,1257322 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04515072 0,12558685 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,04515072 0,12544183 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04515072 0,12529714 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04515072 0,12515279 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,04515072 0,12500877 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,04515072 0,12486508 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04515072 0,12472172 ! sleep GO:0030431 13 6 0,000 0,04515072 0,1245787 ! response to oxygen radical GO:0000305 11 6 0,000 0,04515072 0,12443599 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,04515072 0,12429362 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,04515072 0,12415157 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,04515072 0,12400984 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,04515072 0,12386844 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04515072 0,12372736 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,04515072 0,1235866 ! forebrain regionalization GO:0021871 8 6 0,000 0,04515072 0,12344616 ! male meiosis GO:0007140 7 6 0,000 0,04515072 0,12330604 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04515072 0,12316624 ! response to zinc ion GO:0010043 9 6 0,000 0,04515072 0,12302675 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04515072 0,12288758 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,04515072 0,12274873 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,04515072 0,12261018 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04515072 0,12247195 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04515072 0,12233403 ! malate metabolic process GO:0006108 11 6 0,000 0,04515072 0,12219643 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,04515072 0,12205913 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,04515072 0,12192213 ! protein refolding GO:0042026 15 6 0,000 0,04515072 0,12178545 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04515072 0,12164907 ! opsonization GO:0008228 8 6 0,000 0,04515072 0,121513 ! mating behavior GO:0007617 7 6 0,000 0,04515072 0,12137723 ! neuron remodeling GO:0016322 15 6 0,000 0,04515072 0,12124177 ! erythrocyte maturation GO:0043249 7 6 0,000 0,04515072 0,1211066 ! equilibrioception GO:0050957 14 6 0,000 0,04515072 0,12097174 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,04515072 0,12083718 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,04515072 0,12070291 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04515072 0,12056895 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,04515072 0,12043528 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04515072 0,12030191 ! response to interferon-gamma GO:0034341 15 6 0,000 0,04515072 0,12016883 ! toxin metabolic process GO:0009404 11 6 0,000 0,04515072 0,12003605 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04515072 0,11990356 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04515072 0,11977136 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,04515072 0,11963945 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,04515072 0,11950784 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,04515072 0,11937651 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,04515072 0,11924547 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04515072 0,11911472 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,04515072 0,11898425 ! protein lipoylation GO:0009249 10 6 0,000 0,04515072 0,11885407 ! cysteine metabolic process GO:0006534 10 6 0,000 0,04515072 0,11872418 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04515072 0,11859457 ! glutamate catabolic process GO:0006538 10 6 0,000 0,04515072 0,11846524 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,04515072 0,11833619 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04515072 0,11820742 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,04515072 0,11807894 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,04515072 0,11795073 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04515072 0,1178228 ! hyperosmotic response GO:0006972 9 6 0,000 0,04515072 0,11769515 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,04515072 0,11756777 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,04515072 0,11744067 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,04515072 0,11731385 ! urea metabolic process GO:0019627 7 6 0,000 0,04515072 0,11718729 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04515072 0,11706102 ! neutrophil activation GO:0042119 8 6 0,000 0,04515072 0,11693501 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04515072 0,11680927 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,04515072 0,1166838 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04515072 0,11655861 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04515072 0,11643368 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04515072 0,11630902 ! neuron apoptosis GO:0051402 9 6 0,000 0,04515072 0,11618462 ! nucleoside salvage GO:0043174 9 6 0,000 0,04515072 0,11606049 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,04515072 0,11593663 ! T cell mediated immunity GO:0002456 16 6 0,000 0,04515072 0,11581303 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04515072 0,11568969 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,04515072 0,11556662 ! carnitine transport GO:0015879 10 6 0,000 0,04515072 0,11544381 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,04515072 0,11532125 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04515072 0,11519896 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,04515072 0,11507693 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,04515072 0,11495516 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,04515072 0,11483364 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04515072 0,11471238 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,04515072 0,11459137 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,04515072 0,11447062 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,04515072 0,11435013 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,04515072 0,11422989 ! monocyte differentiation GO:0030224 12 6 0,000 0,04515072 0,1141099 ! response to UV-C GO:0010225 11 6 0,000 0,04515072 0,11399016 ! astrocyte development GO:0014002 15 6 0,000 0,04515072 0,11387067 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,04515072 0,11375144 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04515072 0,11363245 ! interaction with symbiont GO:0051702 13 6 0,000 0,04515072 0,11351371 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04515072 0,11339522 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04515072 0,11327698 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,04515072 0,11315898 ! response to copper ion GO:0046688 10 6 0,000 0,04515072 0,11304123 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,04515072 0,11292372 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,04515072 0,11280646 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04515072 0,11268944 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04515072 0,11257267 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,04515072 0,11245613 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04515072 0,11233984 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,04515072 0,11222378 ! hair follicle maturation GO:0048820 7 6 0,000 0,04515072 0,11210797 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04515072 0,11199239 ! Schwann cell development GO:0014044 15 6 0,000 0,04515072 0,11187706 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,04515072 0,11176196 ! subpallium development GO:0021544 10 6 0,000 0,04515072 0,11164709 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,04515072 0,11153247 ! histone ubiquitination GO:0016574 8 6 0,000 0,04515072 0,11141807 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,04515072 0,11130392 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04515072 0,11118999 ! G2 phase GO:0051319 16 6 0,000 0,04515072 0,1110763 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,04515072 0,11096284 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04515072 0,11084961 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,04515072 0,11073662 ! membrane to membrane docking GO:0022614 14 6 0,000 0,04515072 0,11062385 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04515072 0,11051131 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,04515072 0,11039901 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04515072 0,11028693 ! receptor internalization GO:0031623 10 6 0,000 0,04515072 0,11017507 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,04515072 0,11006345 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,04515072 0,10995205 ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,04515072 0,10984087 ! protein deubiquitination GO:0016579 14 6 0,000 0,04515072 0,10972992 ! negative regulation of neuroblast proliferation GO:0007406 21 6 0,000 0,04515072 0,10961919 ! protein destabilization GO:0031648 9 6 0,000 0,04515072 0,10950869 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04515072 0,10939841 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,04515072 0,10928835 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04515072 0,10917851 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,04515072 0,1090689 ! progesterone metabolic process GO:0042448 10 6 0,000 0,04515072 0,1089595 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,04515072 0,10885032 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,04515072 0,10874136 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,04515072 0,10863262 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,04515072 0,1085241 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04515072 0,10841579 ! determination of adult lifespan GO:0008340 15 6 0,000 0,04515072 0,1083077 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,04515072 0,10819982 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,04515072 0,10809216 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04515072 0,10798471 ! catecholamine transport GO:0051937 9 6 0,000 0,04515072 0,10787748 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,04515072 0,10777046 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04515072 0,10766365 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04515072 0,10755705 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,04515072 0,10745066 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,04515072 0,10734449 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04515072 0,10723852 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,04515072 0,10713276 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04515072 0,10702721 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,04515072 0,10692187 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,04515072 0,10681674 ! regulation of JAK-STAT cascade GO:0046425 70 45 1,000 0,04674091 0,11047017 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,04674091 0,11036176 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 1,000 0,04674091 0,11025356 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 1,000 0,04862445 0,11458416 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 0,04862445 0,11447205 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,04862445 0,11436015 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,05053519 0,11873795 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,05053519 0,11862211 ! regulation of adaptive immune response GO:0002819 84 47 1,000 0,05053519 0,11850649 ! mitochondrial transport GO:0006839 82 48 1,000 0,05247259 0,12292995 ! tRNA transcription GO:0009304 14 7 0,000 0,05247595 0,12281823 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,05247595 0,12269887 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,05247595 0,12257975 ! regulation of helicase activity GO:0051095 15 7 0,000 0,05247595 0,12246085 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,05247595 0,12234219 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,05247595 0,12222376 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,05247595 0,12210555 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,05247595 0,12198758 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,05247595 0,12186983 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05247595 0,1217523 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,05247595 0,12163501 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,05247595 0,12151794 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05247595 0,1214011 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,05247595 0,12128448 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,05247595 0,12116808 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,05247595 0,12105191 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,05247595 0,12093596 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,05247595 0,12082023 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,05247595 0,12070472 ! glycolipid transport GO:0046836 10 7 0,000 0,05247595 0,12058944 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,05247595 0,12047437 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,05247595 0,12035952 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,05247595 0,1202449 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,05247595 0,12013049 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,05247595 0,12001629 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,05247595 0,11990232 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,05247595 0,11978856 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,05247595 0,11967501 ! pericardium development GO:0060039 14 7 0,000 0,05247595 0,11956169 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,05247595 0,11944857 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,05247595 0,11933567 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05247595 0,11922298 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,05247595 0,11911051 ! lipoprotein transport GO:0042953 14 7 0,000 0,05247595 0,11899825 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05247595 0,1188862 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05247595 0,11877436 ! rhythmic behavior GO:0007622 15 7 0,000 0,05247595 0,11866273 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,05247595 0,11855131 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,05247595 0,11844009 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,05247595 0,11832909 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,05247595 0,1182183 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,05247595 0,11810771 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,05247595 0,11799733 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,05247595 0,11788715 ! mechanosensory behavior GO:0007638 14 7 0,000 0,05247595 0,11777718 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,05247595 0,11766742 ! positive regulation of heart rate GO:0010460 10 7 0,000 0,05247595 0,11755786 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05247595 0,1174485 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05247595 0,11733935 ! spinal cord patterning GO:0021511 13 7 0,000 0,05247595 0,1172304 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,05247595 0,11712165 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,05247595 0,1170131 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,05247595 0,11690476 ! adrenal gland development GO:0030325 17 7 0,000 0,05247595 0,11679661 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,05247595 0,11668867 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,05247595 0,11658092 ! ovulation GO:0030728 9 7 0,000 0,05247595 0,11647338 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,05247595 0,11636603 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,05247595 0,11625888 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,05247595 0,11615192 ! microtubule nucleation GO:0007020 20 7 0,000 0,05247595 0,11604517 ! proline biosynthetic process GO:0006561 10 7 0,000 0,05247595 0,1159386 ! thyroid hormone generation GO:0006590 13 7 0,000 0,05247595 0,11583224 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,05247595 0,11572607 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,05247595 0,11562009 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,05247595 0,11551431 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05247595 0,11540872 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05247595 0,11530332 ! galactose metabolic process GO:0006012 13 7 0,000 0,05247595 0,11519812 ! vesicle fusion GO:0006906 17 7 0,000 0,05247595 0,11509311 ! response to dietary excess GO:0002021 8 7 0,000 0,05247595 0,11498829 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,05247595 0,11488366 ! intracellular pH reduction GO:0051452 11 7 0,000 0,05247595 0,11477922 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,05247595 0,11467497 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,05247595 0,11457091 ! purine salvage GO:0043101 10 7 0,000 0,05247595 0,11446704 ! nucleoside transport GO:0015858 8 7 0,000 0,05247595 0,11436335 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,05247595 0,11425986 ! parturition GO:0007567 14 7 0,000 0,05247595 0,11415655 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,05247595 0,11405342 ! rRNA modification GO:0000154 14 7 0,000 0,05247595 0,11395049 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,05247595 0,11384774 ! spindle checkpoint GO:0031577 15 7 0,000 0,05247595 0,11374517 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,05247595 0,11364279 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,05247595 0,11354059 ! macrophage differentiation GO:0030225 11 7 0,000 0,05247595 0,11343858 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05247595 0,11333675 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,05247595 0,1132351 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,05247595 0,11313364 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,05247595 0,11303235 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,05247595 0,11293125 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,05247595 0,11283033 ! fibrinolysis GO:0042730 10 7 0,000 0,05247595 0,11272959 ! eating behavior GO:0042755 7 7 0,000 0,05247595 0,11262903 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,05247595 0,11252865 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,05247595 0,11242844 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,05247595 0,11232842 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,05247595 0,11222857 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,05247595 0,1121289 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,05247595 0,11202941 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,05247595 0,11193009 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,05247595 0,11183095 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,05247595 0,11173198 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,05247595 0,11163319 ! regulation of meiosis GO:0040020 12 7 0,000 0,05247595 0,11153458 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,05247595 0,11143613 ! regulation of lipid transport GO:0032368 14 7 0,000 0,05247595 0,11133787 ! transcription termination GO:0006353 13 7 0,000 0,05247595 0,11123977 ! response to tumor cell GO:0002347 13 7 0,000 0,05247595 0,11114185 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,05247595 0,1110441 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,05247595 0,11094652 ! anaphase GO:0051322 17 7 0,000 0,05247595 0,11084911 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,05247595 0,11075188 ! axonal fasciculation GO:0007413 18 7 0,000 0,05247595 0,11065481 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,05247595 0,11055792 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,05247595 0,11046119 ! diuresis GO:0030146 12 7 0,000 0,05247595 0,11036463 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,05247595 0,11026824 ! thiamin metabolic process GO:0006772 7 7 0,000 0,05247595 0,11017202 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05247595 0,11007597 ! antibiotic transport GO:0042891 9 7 0,000 0,05247595 0,10998009 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,05247595 0,10988437 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05247595 0,10978882 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05247595 0,10969343 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05247595 0,10959821 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,05247595 0,10950316 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,05247595 0,10940827 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,05247595 0,10931354 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,05247595 0,10921898 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,05247595 0,10912458 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05247595 0,10903035 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,05247595 0,10893627 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,05247595 0,10884236 ! adult feeding behavior GO:0008343 9 7 0,000 0,05247595 0,10874861 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,05247595 0,10865503 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,05247595 0,1085616 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,05247595 0,10846833 ! muscle adaptation GO:0043500 14 7 0,000 0,05247595 0,10837523 ! embryonic heart tube development GO:0035050 10 7 0,000 0,05247595 0,10828228 ! retina homeostasis GO:0001895 12 7 0,000 0,05247595 0,10818949 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,05247595 0,10809687 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,05247595 0,1080044 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,05247595 0,10791209 ! protein prenylation GO:0018342 18 7 0,000 0,05247595 0,10781993 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,05247595 0,10772794 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,05247595 0,1076361 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05247595 0,10754441 ! regulation of action potential GO:0001508 95 49 1,000 0,05443615 0,11146671 ! response to temperature stimulus GO:0009266 76 49 1,000 0,05443615 0,11137193 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,05443615 0,1112773 ! neuromuscular process GO:0050905 99 50 1,000 0,05642535 0,11524567 ! regulation of ossification GO:0030278 117 50 1,000 0,05642535 0,11514792 ! positive regulation of cytokine production GO:0001819 86 50 1,000 0,05642535 0,11505034 ! positive regulation of binding GO:0051099 78 51 1,000 0,05843969 0,11905664 ! viral infectious cycle GO:0019058 99 51 1,000 0,05843969 0,11895592 ! response to estrogen stimulus GO:0043627 93 51 1,000 0,05843969 0,11885536 ! embryonic skeletal system development GO:0048706 85 51 1,000 0,05843969 0,11875498 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 0,05843969 0,11865476 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,05974523 0,12120323 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,05974523 0,12110112 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,05974523 0,12099918 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,05974523 0,12089742 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05974523 0,12079582 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05974523 0,1206944 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,05974523 0,12059315 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,05974523 0,12049206 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,05974523 0,12039115 ! meiotic prophase I GO:0007128 13 8 0,000 0,05974523 0,1202904 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05974523 0,12018982 ! oligopeptide transport GO:0006857 15 8 0,000 0,05974523 0,12008942 ! UTP metabolic process GO:0046051 8 8 0,000 0,05974523 0,11998917 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,05974523 0,1198891 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,05974523 0,11978919 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,05974523 0,11968945 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05974523 0,11958988 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05974523 0,11949047 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,05974523 0,11939122 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,05974523 0,11929214 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05974523 0,11919323 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05974523 0,11909447 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,05974523 0,11899589 ! reflex GO:0060004 16 8 0,000 0,05974523 0,11889746 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,05974523 0,1187992 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,05974523 0,1187011 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05974523 0,11860316 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,05974523 0,11850538 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,05974523 0,11840777 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05974523 0,11831031 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,05974523 0,11821302 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,05974523 0,11811588 ! astrocyte differentiation GO:0048708 18 8 0,000 0,05974523 0,11801891 ! histidine metabolic process GO:0006547 16 8 0,000 0,05974523 0,11792209 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05974523 0,11782543 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,05974523 0,11772894 ! glycine catabolic process GO:0006546 13 8 0,000 0,05974523 0,11763259 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,05974523 0,11753641 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,05974523 0,11744038 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,05974523 0,11734451 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,05974523 0,1172488 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05974523 0,11715324 ! macrophage activation GO:0042116 12 8 0,000 0,05974523 0,11705784 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05974523 0,1169626 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,05974523 0,1168675 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,05974523 0,11677257 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,05974523 0,11667778 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,05974523 0,11658316 ! osteoblast development GO:0002076 16 8 0,000 0,05974523 0,11648868 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,05974523 0,11639436 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,05974523 0,11630019 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,05974523 0,11620617 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,05974523 0,1161123 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,05974523 0,11601859 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05974523 0,11592502 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,05974523 0,11583161 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05974523 0,11573835 ! intermediate filament organization GO:0045109 12 8 0,000 0,05974523 0,11564524 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,05974523 0,11555228 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,05974523 0,11545946 ! cellular extravasation GO:0045123 12 8 0,000 0,05974523 0,1153668 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,05974523 0,11527428 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,05974523 0,11518192 ! response to antibiotic GO:0046677 11 8 0,000 0,05974523 0,1150897 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,05974523 0,11499762 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,05974523 0,1149057 ! DNA topological change GO:0006265 12 8 0,000 0,05974523 0,11481392 ! response to tropane GO:0014073 15 8 0,000 0,05974523 0,11472229 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,05974523 0,11463081 ! melanosome transport GO:0032402 13 8 0,000 0,05974523 0,11453947 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05974523 0,11444827 ! mast cell activation GO:0045576 14 8 0,000 0,05974523 0,11435722 ! multicellular organismal aging GO:0010259 18 8 0,000 0,05974523 0,11426632 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,05974523 0,11417556 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05974523 0,11408494 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05974523 0,11399447 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,05974523 0,11390414 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05974523 0,11381396 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05974523 0,11372392 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,05974523 0,11363402 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,05974523 0,11354426 ! intracellular lipid transport GO:0032365 13 8 0,000 0,05974523 0,11345464 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05974523 0,11336517 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05974523 0,11327583 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,05974523 0,11318664 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,05974523 0,11309759 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05974523 0,11300867 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,05974523 0,1129199 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,05974523 0,11283126 ! hormone catabolic process GO:0042447 17 8 0,000 0,05974523 0,11274277 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05974523 0,11265441 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,05974523 0,11256619 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,05974523 0,11247811 ! ATP catabolic process GO:0006200 11 8 0,000 0,05974523 0,11239017 ! blastocyst growth GO:0001832 19 8 0,000 0,05974523 0,11230237 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05974523 0,1122147 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,05974523 0,11212717 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05974523 0,11203977 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05974523 0,11195252 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,05974523 0,11186539 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,05974523 0,11177841 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,05974523 0,11169155 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,05974523 0,11160484 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,05974523 0,11151825 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05974523 0,11143181 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05974523 0,11134549 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05974523 0,11125931 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,05974523 0,11117326 ! synapse organization GO:0050808 85 52 1,000 0,06047866 0,11245106 ! regulation of neuron apoptosis GO:0043523 100 53 1,000 0,06254178 0,11619732 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,06462856 0,11998173 GO:0010863|positive regulation of phospholipase C activity, ! chloride transport GO:0006821 90 55 1,000 0,06673852 0,12380329 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,06673852 0,12370791 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,06673852 0,12361268 ! gastrulation GO:0007369 112 55 1,000 0,06673852 0,12351759 ! heart morphogenesis GO:0003007 97 55 1,000 0,06673852 0,12342265 ! regulation of developmental growth GO:0048638 15 9 0,000 0,06695898 0,12373527 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,06695898 0,1236403 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,06695898 0,12354549 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06695898 0,12345082 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,06695898 0,12335629 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,06695898 0,12326191 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,06695898 0,12316767 ! phosphate transport GO:0006817 19 9 0,000 0,06695898 0,12307358 ! reproductive behavior GO:0019098 19 9 0,000 0,06695898 0,12297963 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06695898 0,12288583 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,06695898 0,12279216 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06695898 0,12269864 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,06695898 0,12260526 ! GTP metabolic process GO:0046039 9 9 0,000 0,06695898 0,12251203 ! RNA methylation GO:0001510 15 9 0,000 0,06695898 0,12241893 ! elastic fiber assembly GO:0048251 15 9 0,000 0,06695898 0,12232598 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,06695898 0,12223317 ! artery development GO:0060840 24 9 0,000 0,06695898 0,1221405 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,06695898 0,12204797 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,06695898 0,12195558 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,06695898 0,12186333 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,06695898 0,12177121 ! chemosensory behavior GO:0007635 20 9 0,000 0,06695898 0,12167924 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,06695898 0,12158741 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06695898 0,12149571 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,06695898 0,12140416 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,06695898 0,12131274 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,06695898 0,12122146 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06695898 0,12113031 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06695898 0,12103931 ! protein targeting to ER GO:0045047 22 9 0,000 0,06695898 0,12094844 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,06695898 0,1208577 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,06695898 0,1207671 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,06695898 0,12067664 ! endosome organization GO:0007032 17 9 0,000 0,06695898 0,12058632 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06695898 0,12049612 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06695898 0,12040607 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06695898 0,12031614 ! mannose metabolic process GO:0006013 13 9 0,000 0,06695898 0,12022636 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,06695898 0,1201367 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,06695898 0,12004718 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,06695898 0,11995779 ! receptor clustering GO:0043113 18 9 0,000 0,06695898 0,11986854 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,06695898 0,11977942 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06695898 0,11969043 ! ruffle organization GO:0031529 15 9 0,000 0,06695898 0,11960157 ! retinol metabolic process GO:0042572 18 9 0,000 0,06695898 0,11951285 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,06695898 0,11942425 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,06695898 0,11933579 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,06695898 0,11924746 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,06695898 0,11915926 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,06695898 0,11907119 ! oligodendrocyte development GO:0014003 10 9 0,000 0,06695898 0,11898325 ! segment specification GO:0007379 13 9 0,000 0,06695898 0,11889544 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06695898 0,11880776 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,06695898 0,1187202 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06695898 0,11863278 ! response to amine stimulus GO:0014075 13 9 0,000 0,06695898 0,11854549 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06695898 0,11845832 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,06695898 0,11837128 ! erythrocyte development GO:0048821 15 9 0,000 0,06695898 0,11828437 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06695898 0,11819759 ! renal water homeostasis GO:0003091 14 9 0,000 0,06695898 0,11811094 ! postreplication repair GO:0006301 22 9 0,000 0,06695898 0,11802441 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,06695898 0,11793801 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,06695898 0,11785173 ! icosanoid secretion GO:0032309 15 9 0,000 0,06695898 0,11776558 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06695898 0,11767956 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 15 9 0,000 0,06695898 0,11759366 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,06695898 0,11750789 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,06695898 0,11742224 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06695898 0,11733672 ! sterol catabolic process GO:0016127 11 9 0,000 0,06695898 0,11725132 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06695898 0,11716605 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,06695898 0,1170809 ! S phase GO:0051320 9 9 0,000 0,06695898 0,11699587 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,06695898 0,11691097 ! musculoskeletal movement GO:0050881 14 9 0,000 0,06695898 0,11682619 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,06695898 0,11674153 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,06695898 0,116657 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06695898 0,11657259 ! purine base metabolic process GO:0006144 21 9 0,000 0,06695898 0,1164883 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,06695898 0,11640413 ! pigment granule transport GO:0051904 17 9 0,000 0,06695898 0,11632008 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,06695898 0,11623616 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,06695898 0,11615236 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06695898 0,11606867 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06695898 0,11598511 ! mitochondrion localization GO:0051646 15 9 0,000 0,06695898 0,11590167 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,06887117 0,11912584 ! positive regulation of organelle organization GO:0010638 100 56 1,000 0,06887117 0,11904026 ! muscle fiber development GO:0048747 112 57 1,000 0,07102606 0,12267675 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,07102606 0,12258875 ! regulation of intracellular transport GO:0032386 101 57 1,000 0,07102606 0,12250087 ! adult behavior GO:0030534 99 58 1,000 0,07320273 0,12616459 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,07320273 0,12607427 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,07411763 0,12755867 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,07411763 0,12746749 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,07411763 0,12737644 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,07411763 0,12728552 ! synapsis GO:0007129 13 10 0,000 0,07411763 0,12719473 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,07411763 0,12710407 ! N-glycan processing GO:0006491 20 10 0,000 0,07411763 0,12701354 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,07411763 0,12692314 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,07411763 0,12683287 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,07411763 0,12674273 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,07411763 0,12665271 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,07411763 0,12656282 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,07411763 0,12647306 ! androgen metabolic process GO:0008209 17 10 0,000 0,07411763 0,12638343 ! phospholipid efflux GO:0033700 16 10 0,000 0,07411763 0,12629392 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,07411763 0,12620454 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,07411763 0,12611529 ! pathogenesis GO:0009405 13 10 0,000 0,07411763 0,12602616 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07411763 0,12593716 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,07411763 0,12584828 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,07411763 0,12575953 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,07411763 0,12567091 ! endoderm development GO:0007492 16 10 0,000 0,07411763 0,12558241 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,07411763 0,12549403 ! arginine catabolic process GO:0006527 13 10 0,000 0,07411763 0,12540578 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,07411763 0,12531765 ! proline metabolic process GO:0006560 13 10 0,000 0,07411763 0,12522965 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,07411763 0,12514177 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,07411763 0,12505401 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,07411763 0,12496637 ! V(D)J recombination GO:0033151 28 10 0,000 0,07411763 0,12487886 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07411763 0,12479147 ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,07411763 0,12470421 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,07411763 0,12461706 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,07411763 0,12453004 ! multicellular organism growth GO:0035264 18 10 0,000 0,07411763 0,12444314 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,07411763 0,12435636 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,07411763 0,1242697 ! epithelial cell development GO:0002064 20 10 0,000 0,07411763 0,12418316 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,07411763 0,12409674 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,07411763 0,12401044 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,07411763 0,12392426 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,07411763 0,12383821 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,07411763 0,12375227 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 0,000 0,07411763 0,12366645 ! copper ion homeostasis GO:0055070 13 10 0,000 0,07411763 0,12358075 ! brain morphogenesis GO:0048854 23 10 0,000 0,07411763 0,12349516 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,07411763 0,1234097 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,07411763 0,12332435 ! blastoderm segmentation GO:0007350 18 10 0,000 0,07411763 0,12323913 ! response to dsRNA GO:0043331 20 10 0,000 0,07411763 0,12315402 ! DNA ligation GO:0006266 19 10 0,000 0,07411763 0,12306902 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07411763 0,12298415 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,07411763 0,12289939 ! melanosome localization GO:0032400 16 10 0,000 0,07411763 0,12281475 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,07411763 0,12273022 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,07411763 0,12264582 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,07411763 0,12256152 ! mRNA cleavage GO:0006379 17 10 0,000 0,07411763 0,12247735 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,07411763 0,12239329 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07411763 0,12230934 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,07411763 0,12222551 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,07411763 0,12214179 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,07411763 0,12205819 ! salivary gland development GO:0007431 27 10 0,000 0,07411763 0,1219747 ! prophase GO:0051324 15 10 0,000 0,07411763 0,12189133 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07411763 0,12180807 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,07411763 0,12172493 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,07411763 0,12164189 ! midbrain development GO:0030901 13 10 0,000 0,07411763 0,12155898 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07411763 0,12147617 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,07411763 0,12139348 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,07411763 0,1213109 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,07411763 0,12122843 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,07411763 0,12114607 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,07411763 0,12106383 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,07411763 0,12098169 ! detection of calcium ion GO:0005513 23 10 0,000 0,07411763 0,12089967 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,07411763 0,12081776 ! cerebellar cortex development GO:0021695 15 10 0,000 0,07411763 0,12073596 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,07411763 0,12065427 ! activation of innate immune response GO:0002218 12 10 0,000 0,07411763 0,1205727 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,07411763 0,12049123 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,07411763 0,12040987 ! establishment of cell polarity GO:0030010 16 10 0,000 0,07411763 0,12032862 ! cytokine-mediated signaling pathway GO:0019221 97 59 1,000 0,0754007 0,12232912 ! establishment of organelle localization GO:0051656 109 59 1,000 0,0754007 0,12224669 ! kidney development GO:0001822 122 60 1,000 0,07761954 0,12575934 ! mesoderm development GO:0007498 119 61 1,000 0,07985879 0,12930031 ! respiratory burst GO:0045730 17 11 0,000 0,08122159 0,13141838 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,08122159 0,13133006 ! neuron fate specification GO:0048665 17 11 0,000 0,08122159 0,13124186 ! telencephalon cell migration GO:0022029 20 11 0,000 0,08122159 0,13115378 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,08122159 0,13106582 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,08122159 0,13097797 ! thyroid gland development GO:0030878 26 11 0,000 0,08122159 0,13089025 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,08122159 0,13080263 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,08122159 0,13071514 ! response to pain GO:0048265 24 11 0,000 0,08122159 0,13062777 ! bone resorption GO:0045453 16 11 0,000 0,08122159 0,13054051 ! ventral spinal cord development GO:0021517 21 11 0,000 0,08122159 0,13045336 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,08122159 0,13036634 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,08122159 0,13027942 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,08122159 0,13019263 ! melanocyte differentiation GO:0030318 21 11 0,000 0,08122159 0,13010595 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,08122159 0,13001939 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,08122159 0,12993294 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,08122159 0,1298466 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,08122159 0,12976038 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,08122159 0,12967428 ! lipid digestion GO:0044241 18 11 0,000 0,08122159 0,12958829 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,08122159 0,12950241 ! UV protection GO:0009650 19 11 0,000 0,08122159 0,12941665 ! adult heart development GO:0007512 14 11 0,000 0,08122159 0,129331 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,08122159 0,12924546 ! temperature homeostasis GO:0001659 17 11 0,000 0,08122159 0,12916004 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,08122159 0,12907473 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,08122159 0,12898953 ! regulation of organ growth GO:0046620 13 11 0,000 0,08122159 0,12890444 ! pigment granule localization GO:0051875 20 11 0,000 0,08122159 0,12881947 ! vasoconstriction GO:0042310 18 11 0,000 0,08122159 0,12873461 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,08122159 0,12864986 ! embryonic axis specification GO:0000578 18 11 0,000 0,08122159 0,12856522 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,08122159 0,12848069 ! snRNA metabolic process GO:0016073 24 11 0,000 0,08122159 0,12839628 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,08122159 0,12831197 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,08122159 0,12822778 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,08122159 0,1281437 ! zymogen activation GO:0031638 15 11 0,000 0,08122159 0,12805972 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,08122159 0,12797586 ! nucleosome positioning GO:0016584 15 11 0,000 0,08122159 0,12789211 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,08122159 0,12780846 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,08122159 0,12772493 ! acid secretion GO:0046717 18 11 0,000 0,08122159 0,1276415 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,08122159 0,12755818 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,08122159 0,12747497 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,08122159 0,12739188 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,08122159 0,12730888 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,08122159 0,127226 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,08122159 0,12714322 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,08122159 0,12706056 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,08122159 0,126978 ! embryonic gut development GO:0048566 15 11 0,000 0,08122159 0,12689554 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,08122159 0,1268132 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,08122159 0,12673096 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,08122159 0,12664882 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,08122159 0,1265668 ! defense response to fungus GO:0050832 13 11 0,000 0,08122159 0,12648488 ! lysogeny GO:0030069 21 11 0,000 0,08122159 0,12640306 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,08122159 0,12632136 ! sequestering of metal ion GO:0051238 14 11 0,000 0,08122159 0,12623975 ! lamellipodium assembly GO:0030032 20 11 0,000 0,08122159 0,12615825 ! nucleus localization GO:0051647 19 11 0,000 0,08122159 0,12607686 ! regulation of synapse organization GO:0050807 17 11 0,000 0,08122159 0,12599557 ! viral reproductive process GO:0022415 126 62 1,000 0,08211802 0,1273041 ! gonad development GO:0008406 98 62 1,000 0,08211802 0,12722213 ! detection of external stimulus GO:0009581 91 63 1,000 0,08439679 0,13066839 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,08669467 0,1341398 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,08827127 0,13649144 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,08827127 0,13640378 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,08827127 0,13631622 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,08827127 0,13622879 ! virus-host interaction GO:0019048 29 12 0,000 0,08827127 0,13614146 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,08827127 0,13605425 ! mating GO:0007618 17 12 0,000 0,08827127 0,13596714 ! protein complex disassembly GO:0043241 27 12 0,000 0,08827127 0,13588015 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,08827127 0,13579327 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,08827127 0,1357065 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,08827127 0,13561985 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,08827127 0,1355333 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08827127 0,13544686 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,08827127 0,13536053 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,08827127 0,13527432 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,08827127 0,13518821 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,08827127 0,13510221 ! drug transport GO:0015893 16 12 0,000 0,08827127 0,13501632 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,08827127 0,13493055 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,08827127 0,13484488 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,08827127 0,13475931 ! polyamine metabolic process GO:0006595 17 12 0,000 0,08827127 0,13467386 ! mitotic spindle organization GO:0007052 21 12 0,000 0,08827127 0,13458852 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,08827127 0,13450328 ! forebrain cell migration GO:0021885 21 12 0,000 0,08827127 0,13441815 ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,08827127 0,13433313 ! entry into host cell GO:0030260 32 12 0,000 0,08827127 0,13424822 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,08827127 0,13416341 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08827127 0,13407871 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,08827127 0,13399412 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,08827127 0,13390963 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,08827127 0,13382525 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08827127 0,13374098 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,08827127 0,13365681 ! protein homotetramerization GO:0051289 21 12 0,000 0,08827127 0,13357275 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,08827127 0,1334888 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,08827127 0,13340495 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08827127 0,1333212 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,08827127 0,13323756 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,08827127 0,13315403 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08827127 0,1330706 ! fucose catabolic process GO:0019317 22 12 0,000 0,08827127 0,13298728 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,08827127 0,13290405 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,08827127 0,13282094 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,08827127 0,13273792 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,08827127 0,13265501 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,08827127 0,13257221 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,08827127 0,13248951 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,08827127 0,13240691 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,08827127 0,13232441 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,08827127 0,13224202 ! response to cold GO:0009409 17 12 0,000 0,08827127 0,13215973 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,08827127 0,13207754 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,08827127 0,13199545 ! regulation of cytokine biosynthetic process GO:0042035 95 65 1,000 0,08901124 0,13301928 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,08901124 0,13293671 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 111 65 1,000 0,08901124 0,13285425 ! secondary metabolic process GO:0019748 116 66 1,000 0,09134608 0,13625459 ! developmental maturation GO:0021700 116 66 1,000 0,09134608 0,13617017 ! regulation of cellular response to stress GO:0080135 128 67 1,000 0,09369877 0,13959086 ! chromosome segregation GO:0007059 113 67 1,000 0,09369877 0,13950448 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,09369877 0,1394182 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,09369877 0,13933203 ! adaptive immune response GO:0002250 119 67 1,000 0,09369877 0,13924597 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 1,000 0,09369877 0,13916002 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0952671 0,141402 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,0952671 0,14131482 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0952671 0,14122775 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,0952671 0,14114079 ! lipid localization GO:0010876 28 13 0,000 0,0952671 0,14105393 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,0952671 0,14096718 ! organelle fusion GO:0048284 32 13 0,000 0,0952671 0,14088054 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,0952671 0,140794 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,0952671 0,14070757 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,0952671 0,14062125 ! endocrine pancreas development GO:0031018 22 13 0,000 0,0952671 0,14053503 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,0952671 0,14044892 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,0952671 0,14036291 ! methionine metabolic process GO:0006555 27 13 0,000 0,0952671 0,14027701 ! plasma membrane organization GO:0007009 24 13 0,000 0,0952671 0,14019121 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,0952671 0,14010552 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,0952671 0,14001994 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,0952671 0,13993445 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,0952671 0,13984908 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,0952671 0,1397638 ! response to X-ray GO:0010165 25 13 0,000 0,0952671 0,13967863 ! cytokine metabolic process GO:0042107 22 13 0,000 0,0952671 0,13959357 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,0952671 0,1395086 ! exocrine system development GO:0035272 32 13 0,000 0,0952671 0,13942374 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,0952671 0,13933899 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,0952671 0,13925433 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,0952671 0,13916978 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,0952671 0,13908534 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,0952671 0,13900099 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,0952671 0,13891675 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,0952671 0,13883261 ! regulation of cellular pH GO:0030641 22 13 0,000 0,0952671 0,13874857 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0952671 0,13866463 ! ribosome assembly GO:0042255 17 13 0,000 0,0952671 0,1385808 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,0952671 0,13849706 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,0952671 0,13841343 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,0952671 0,13832989 ! regulation of epidermis development GO:0045682 19 13 0,000 0,0952671 0,13824646 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0952671 0,13816313 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,0952671 0,1380799 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,0952671 0,13799677 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,0952671 0,13791374 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,0952671 0,13783081 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,0952671 0,13774798 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,0952671 0,13766525 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,0952671 0,13758261 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,0952671 0,13750008 ! insulin secretion GO:0030073 23 13 0,000 0,0952671 0,13741765 ! actin filament polymerization GO:0030041 24 13 0,000 0,0952671 0,13733531 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,0952671 0,13725308 ! acrosome reaction GO:0007340 18 13 0,000 0,0952671 0,13717094 ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,0960689 0,13824269 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 134 68 1,000 0,0960689 0,13816006 ! regulation of lipase activity GO:0060191 130 68 1,000 0,0960689 0,13807753 ! cell cycle checkpoint GO:0000075 137 69 1,000 0,09845608 0,14142408 ! appendage morphogenesis GO:0035107 135 70 1,000 0,10085991 0,14479053 GO:0035108|limb morphogenesis, ! rRNA transcription GO:0009303 25 14 0,000 0,10220947 0,14664043 ! lactation GO:0007595 26 14 0,000 0,10220947 0,14655304 ! reproductive cellular process GO:0048610 20 14 0,000 0,10220947 0,14646575 ! tRNA modification GO:0006400 20 14 0,000 0,10220947 0,14637857 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,10220947 0,14629149 ! water transport GO:0006833 21 14 0,000 0,10220947 0,14620451 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,10220947 0,14611764 ! non-recombinational repair GO:0000726 25 14 0,000 0,10220947 0,14603087 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,10220947 0,14594421 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,10220947 0,14585765 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,10220947 0,14577119 ! RNA polyadenylation GO:0043631 30 14 0,000 0,10220947 0,14568483 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,10220947 0,14559857 ! palate development GO:0060021 31 14 0,000 0,10220947 0,14551242 ! regulated secretory pathway GO:0045055 23 14 0,000 0,10220947 0,14542637 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,10220947 0,14534042 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,10220947 0,14525457 ! arginine metabolic process GO:0006525 17 14 0,000 0,10220947 0,14516883 ! regulation of heart rate GO:0002027 24 14 0,000 0,10220947 0,14508318 ! organic alcohol transport GO:0015850 29 14 0,000 0,10220947 0,14499764 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,10220947 0,14491219 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,10220947 0,14482685 ! embryo implantation GO:0007566 30 14 0,000 0,10220947 0,14474161 ! neutral amino acid transport GO:0015804 26 14 0,000 0,10220947 0,14465647 ! L-amino acid transport GO:0015807 30 14 0,000 0,10220947 0,14457142 ! bone mineralization GO:0030282 17 14 0,000 0,10220947 0,14448648 ! stem cell development GO:0048864 43 14 0,000 0,10220947 0,14440164 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,10220947 0,1443169 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10220947 0,14423225 ! cerebellum development GO:0021549 21 14 0,000 0,10220947 0,14414771 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,10220947 0,14406326 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,10220947 0,14397892 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,10220947 0,14389467 ! cofactor transport GO:0051181 26 14 0,000 0,10220947 0,14381052 ! NADP metabolic process GO:0006739 24 14 0,000 0,10220947 0,14372647 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,10220947 0,14364252 ! intestinal absorption GO:0050892 25 14 0,000 0,10220947 0,14355866 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,10220947 0,14347491 ! oxygen transport GO:0015671 21 14 0,000 0,10220947 0,14339125 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,10220947 0,14330769 ! male genitalia development GO:0030539 24 14 0,000 0,10220947 0,14322422 ! regulation of axon extension GO:0030516 37 14 0,000 0,10220947 0,14314086 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,10220947 0,14305759 ! appendage development GO:0048736 136 71 1,000 0,10327998 0,14447188 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 1,000 0,10327998 0,14438793 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,10327998 0,14430409 ! regulation of immune effector process GO:0002697 137 71 1,000 0,10327998 0,14422033 ! carbohydrate transport GO:0008643 110 72 1,000 0,10571592 0,14753626 ! learning or memory GO:0007611 147 73 1,000 0,10816734 0,15086993 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10909881 0,15208096 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! superoxide anion generation GO:0042554 20 15 0,000 0,10909881 0,1519929 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,10909881 0,15190494 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,10909881 0,15181708 ! copper ion transport GO:0006825 20 15 0,000 0,10909881 0,15172932 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,10909881 0,15164167 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,10909881 0,15155412 ! sulfate transport GO:0008272 23 15 0,000 0,10909881 0,15146666 ! response to cAMP GO:0051591 22 15 0,000 0,10909881 0,15137931 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,10909881 0,15129206 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,10909881 0,15120491 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,10909881 0,15111786 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,10909881 0,15103091 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,10909881 0,15094407 ! response to hexose stimulus GO:0009746 22 15 0,000 0,10909881 0,15085732 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,10909881 0,15077067 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,10909881 0,15068412 ! pituitary gland development GO:0021983 29 15 0,000 0,10909881 0,15059766 ! vesicle coating GO:0006901 33 15 0,000 0,10909881 0,15051131 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,10909881 0,15042506 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,10909881 0,15033891 ! regulation of exocytosis GO:0017157 22 15 0,000 0,10909881 0,15025285 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,10909881 0,15016689 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,10909881 0,15008103 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,10909881 0,14999527 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,10909881 0,14990961 ! regulation of vasodilation GO:0042312 26 15 0,000 0,10909881 0,14982405 ! mRNA splice site selection GO:0006376 38 15 0,000 0,10909881 0,14973858 ! tissue regeneration GO:0042246 26 15 0,000 0,10909881 0,14965321 ! water homeostasis GO:0030104 27 15 0,000 0,10909881 0,14956794 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10909881 0,14948276 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,10909881 0,14939768 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10909881 0,1493127 ! heme biosynthetic process GO:0006783 29 15 0,000 0,10909881 0,14922782 ! cell killing GO:0001906 29 15 0,000 0,10909881 0,14914303 ! detection of bacterium GO:0016045 18 15 0,000 0,10909881 0,14905834 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,10909881 0,14897374 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,10909881 0,14888924 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,10909881 0,14880484 ! peptide hormone processing GO:0016486 23 15 0,000 0,10909881 0,14872053 ! organelle localization GO:0051640 136 74 1,000 0,11063387 0,15072768 ! phosphoinositide-mediated signaling GO:0048015 131 75 1,000 0,11311512 0,15402093 ! rhythmic process GO:0048511 128 75 1,000 0,11311512 0,15393381 ! development of primary sexual characteristics GO:0045137 124 76 1,000 0,11561074 0,15724106 ! regulation of catabolic process GO:0009894 161 76 1,000 0,11561074 0,15715222 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,1159355 0,1575047 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,1159355 0,15741581 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,1159355 0,15732703 ! bone remodeling GO:0046849 27 16 0,000 0,1159355 0,15723834 ! filopodium assembly GO:0046847 32 16 0,000 0,1159355 0,15714976 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 0,000 0,1159355 0,15706127 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,1159355 0,15697289 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,1159355 0,1568846 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,1159355 0,15679641 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,1159355 0,15670832 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,1159355 0,15662034 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,1159355 0,15653244 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,1159355 0,15644465 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,1159355 0,15635696 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,1159355 0,15626937 ! glutamate metabolic process GO:0006536 22 16 0,000 0,1159355 0,15618187 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,1159355 0,15609447 ! response to osmotic stress GO:0006970 25 16 0,000 0,1159355 0,15600717 ! lysosomal transport GO:0007041 26 16 0,000 0,1159355 0,15591996 ! fructose metabolic process GO:0006000 25 16 0,000 0,1159355 0,15583286 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,1159355 0,15574585 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,1159355 0,15565894 ! intermediate filament-based process GO:0045103 32 16 0,000 0,1159355 0,15557212 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,1159355 0,15548541 ! axon cargo transport GO:0008088 43 16 0,000 0,1159355 0,15539878 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,1159355 0,15531226 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,1159355 0,15522583 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,1159355 0,1551395 ! DNA replication initiation GO:0006270 27 16 0,000 0,1159355 0,15505326 ! neuron recognition GO:0008038 35 16 0,000 0,1159355 0,15496712 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,1159355 0,15488108 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,1159355 0,15479513 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,1159355 0,15470927 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,1159355 0,15462351 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,1159355 0,15453785 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,1159355 0,15445228 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,1159355 0,15436681 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,1159355 0,15428143 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,1159355 0,15419614 ! response to steroid hormone stimulus GO:0048545 137 78 1,000 0,1206436 0,16036934 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,12271996 0,16303932 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,12271996 0,16294935 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,12271996 0,16285947 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,12271996 0,16276969 ! signal complex assembly GO:0007172 41 17 0,000 0,12271996 0,16268001 ! gene silencing by RNA GO:0031047 36 17 0,000 0,12271996 0,16259043 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,12271996 0,16250094 ! glial cell development GO:0021782 27 17 0,000 0,12271996 0,16241156 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,12271996 0,16232227 ! adult walking behavior GO:0007628 33 17 0,000 0,12271996 0,16223309 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,12271996 0,162144 ! myoblast differentiation GO:0045445 45 17 0,000 0,12271996 0,162055 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,12271996 0,16196611 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,12271996 0,16187731 ! glycine metabolic process GO:0006544 28 17 0,000 0,12271996 0,16178861 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,12271996 0,16170001 ! NAD metabolic process GO:0019674 29 17 0,000 0,12271996 0,1616115 ! membrane budding GO:0006900 37 17 0,000 0,12271996 0,16152309 ! DNA integration GO:0015074 29 17 0,000 0,12271996 0,16143478 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,12271996 0,16134657 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,12271996 0,16125845 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,12271996 0,16117042 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,12271996 0,1610825 ! genitalia development GO:0048806 30 17 0,000 0,12271996 0,16099467 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,12271996 0,16090693 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,12271996 0,16081929 ! steroid catabolic process GO:0006706 31 17 0,000 0,12271996 0,16073175 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,12271996 0,1606443 ! gas transport GO:0015669 25 17 0,000 0,12271996 0,16055694 ! organic cation transport GO:0015695 31 17 0,000 0,12271996 0,16046968 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,12271996 0,16038252 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,12271996 0,16029545 ! microspike assembly GO:0030035 36 17 0,000 0,12271996 0,16020847 ! activation of protein kinase activity GO:0032147 147 79 1,000 0,12318013 0,16072202 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,12318013 0,1606349 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,12318013 0,16054789 ! response to metal ion GO:0010038 140 80 1,000 0,1257296 0,16378204 ! cellular lipid catabolic process GO:0044242 134 80 1,000 0,1257296 0,16369341 ! inorganic anion transport GO:0015698 138 80 1,000 0,1257296 0,16360488 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,12945257 0,16835832 ! neuron maturation GO:0042551 42 18 0,000 0,12945257 0,16826736 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,12945257 0,1681765 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,12945257 0,16808575 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,12945257 0,16799508 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,12945257 0,16790452 ! memory GO:0007613 31 18 0,000 0,12945257 0,16781406 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,12945257 0,16772369 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,12945257 0,16763342 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,12945257 0,16754324 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,12945257 0,16745316 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,12945257 0,16736318 ! glutamine metabolic process GO:0006541 29 18 0,000 0,12945257 0,1672733 ! response to retinoic acid GO:0032526 26 18 0,000 0,12945257 0,16718351 ! response to fungus GO:0009620 21 18 0,000 0,12945257 0,16709382 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,12945257 0,16700423 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,12945257 0,16691473 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,12945257 0,16682533 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,12945257 0,16673602 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,12945257 0,16664681 ! vitamin transport GO:0051180 27 18 0,000 0,12945257 0,16655769 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,12945257 0,16646867 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,12945257 0,16637975 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,12945257 0,16629092 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,12945257 0,16620218 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,12945257 0,16611354 ! response to nutrient GO:0007584 125 82 1,000 0,13086596 0,16783769 ! regulation of ligase activity GO:0051340 142 84 1,000 0,13604998 0,17439331 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,13604998 0,17430045 ! protein secretion GO:0009306 39 19 0,000 0,13613374 0,17431494 ! positive regulation of translation GO:0045727 30 19 0,000 0,13613374 0,17422222 ! negative regulation of defense response GO:0031348 25 19 0,000 0,13613374 0,1741296 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,13613374 0,17403708 ! skin development GO:0043588 36 19 0,000 0,13613374 0,17394465 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,13613374 0,17385232 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,13613374 0,17376009 ! bile acid metabolic process GO:0008206 29 19 0,000 0,13613374 0,17366796 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,13613374 0,17357593 ! cerebral cortex development GO:0021987 36 19 0,000 0,13613374 0,17348399 ! pigmentation during development GO:0048066 41 19 0,000 0,13613374 0,17339215 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,13613374 0,17330041 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,13613374 0,17320877 ! heme metabolic process GO:0042168 36 19 0,000 0,13613374 0,17311722 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,13613374 0,17302577 ! plasma membrane fusion GO:0045026 28 19 0,000 0,13613374 0,17293441 ! peptide cross-linking GO:0018149 37 19 0,000 0,13613374 0,17284315 ! protein export from nucleus GO:0006611 36 19 0,000 0,13613374 0,17275199 ! heart process GO:0003015 30 19 0,000 0,13613374 0,17266093 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,13613374 0,17256996 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,13613374 0,17247908 ! visual learning GO:0008542 36 19 0,000 0,13613374 0,1723883 ! cell-cell junction organization GO:0045216 35 19 0,000 0,13613374 0,17229762 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,13613374 0,17220703 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,13613374 0,17211654 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,13613374 0,17202614 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,13613374 0,17193584 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,13613374 0,17184563 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,13613374 0,17175552 ! cilium assembly GO:0042384 37 19 0,000 0,13613374 0,1716655 ! peptide hormone secretion GO:0030072 31 19 0,000 0,13613374 0,17157558 ! response to inorganic substance GO:0010035 153 86 1,000 0,141279 0,17796716 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,14276385 0,1797435 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,14276385 0,17964949 ! positive regulation of ossification GO:0045778 47 20 0,000 0,14276385 0,17955558 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,14276385 0,17946177 ! cAMP metabolic process GO:0046058 36 20 0,000 0,14276385 0,17936805 ! response to vitamin GO:0033273 31 20 0,000 0,14276385 0,17927444 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,14276385 0,17918092 ! retinoid metabolic process GO:0001523 32 20 0,000 0,14276385 0,1790875 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,14276385 0,17899418 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,14276385 0,17890095 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,14276385 0,17880782 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,14276385 0,17871479 GO:0032392|DNA geometric change, ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,14276385 0,17862185 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,14276385 0,17852901 ! body fluid secretion GO:0007589 31 20 0,000 0,14276385 0,17843627 ! peptide secretion GO:0002790 35 20 0,000 0,14276385 0,17834363 ! stem cell differentiation GO:0048863 53 20 0,000 0,14276385 0,17825108 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,14276385 0,17815862 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,14276385 0,17806626 ! sensory perception of pain GO:0019233 30 20 0,000 0,14276385 0,177974 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,14276385 0,17788184 ! diencephalon development GO:0021536 34 20 0,000 0,14276385 0,17778976 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,14276385 0,17769779 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,14276385 0,17760591 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,14276385 0,17751412 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,14276385 0,17742243 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,14276385 0,17733083 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,14276385 0,17723933 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,14276385 0,17714792 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,14276385 0,17705661 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,14276385 0,17696539 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,14276385 0,17687427 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,14276385 0,17678323 ! regulation of protein transport GO:0051223 154 87 1,000 0,14390959 0,17811032 GO:0070201|regulation of establishment of protein localization, ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,1493433 0,18474034 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,1493433 0,18464541 ! hormone secretion GO:0046879 38 21 0,000 0,1493433 0,18455057 ! glycerol metabolic process GO:0006071 34 21 0,000 0,1493433 0,18445584 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,1493433 0,18436119 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,1493433 0,18426665 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,1493433 0,1841722 ! axis specification GO:0009798 38 21 0,000 0,1493433 0,18407785 ! smooth muscle contraction GO:0006939 46 21 0,000 0,1493433 0,1839836 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,1493433 0,18388944 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,1493433 0,18379538 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,1493433 0,18370142 ! cytolysis GO:0019835 24 21 0,000 0,1493433 0,18360755 ! vasodilation GO:0042311 39 21 0,000 0,1493433 0,18351377 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,1493433 0,1834201 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,1493433 0,18332651 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,1493433 0,18323303 ! collagen fibril organization GO:0030199 59 21 0,000 0,1493433 0,18313964 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,1493433 0,18304634 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,1493433 0,18295314 ! negative regulation of intracellular transport GO:0032387 41 21 0,000 0,1493433 0,18286004 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,1493433 0,18276702 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,1493433 0,18267411 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,1493433 0,18258128 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,1493433 0,18248856 ! collagen catabolic process GO:0030574 28 21 0,000 0,1493433 0,18239592 ! sperm-egg recognition GO:0035036 21 21 0,000 0,1493433 0,18230338 ! response to protein stimulus GO:0051789 149 91 1,000 0,1545318 0,18854133 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,15587246 0,19008066 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,15587246 0,18998436 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,15587246 0,18988817 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,15587246 0,18979207 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,15587246 0,18969607 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,15587246 0,18960017 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,15587246 0,18950436 ! keratinization GO:0031424 28 22 0,000 0,15587246 0,18940865 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,15587246 0,18931304 ! sensory perception of taste GO:0050909 28 22 0,000 0,15587246 0,18921753 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 0,000 0,15587246 0,18912211 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,15587246 0,18902678 ! vacuolar transport GO:0007034 36 22 0,000 0,15587246 0,18893155 ! lysosome organization GO:0007040 41 22 0,000 0,15587246 0,18883642 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,15587246 0,18874139 ! fucose metabolic process GO:0006004 39 22 0,000 0,15587246 0,18864645 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,15587246 0,1885516 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,15587246 0,18845685 GO:0060415|muscle tissue morphogenesis, ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,15587246 0,1883622 ! sarcomere organization GO:0045214 30 22 0,000 0,15587246 0,18826764 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,15587246 0,18817317 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,15587246 0,1880788 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,15587246 0,18798453 ! carbohydrate biosynthetic process GO:0016051 141 93 1,000 0,15989857 0,19274347 ! positive regulation of DNA replication GO:0045740 43 23 0,000 0,16235172 0,19560253 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,16235172 0,19550463 ! viral genome replication GO:0019079 41 23 0,000 0,16235172 0,19540683 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,16235172 0,19530912 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,16235172 0,19521152 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,16235172 0,19511401 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,16235172 0,1950166 GO:0006044|N-acetylglucosamine metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,16235172 0,19491928 ! visual behavior GO:0007632 42 23 0,000 0,16235172 0,19482207 ! peroxisome organization GO:0007031 37 23 0,000 0,16235172 0,19472495 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,16235172 0,19462793 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,16235172 0,194531 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,16235172 0,19443417 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,16235172 0,19433744 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,16235172 0,1942408 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,16235172 0,19414426 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,16235172 0,19404781 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,16235172 0,19395146 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,16235172 0,19385521 ! fatty acid transport GO:0015908 44 23 0,000 0,16235172 0,19375905 ! platelet activation GO:0030168 37 23 0,000 0,16235172 0,19366299 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,16235172 0,19356702 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,16235172 0,19347115 ! hormone transport GO:0009914 40 23 0,000 0,16235172 0,19337537 ! cell-cell recognition GO:0009988 25 23 0,000 0,16235172 0,19327969 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,16235172 0,1931841 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,16235172 0,1930886 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,16235172 0,1929932 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,16235172 0,1928979 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,16235172 0,19280269 ! transcription initiation GO:0006352 153 94 1,000 0,16259484 0,19299615 ! positive regulation of immune response GO:0050778 156 96 1,000 0,16801171 0,19932751 ! detection of stimulus GO:0051606 151 96 1,000 0,16801171 0,19922927 ! protein import into nucleus, translocation GO:0000060 46 24 0,000 0,16878147 0,20004345 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,16878147 0,19994496 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,16878147 0,19984656 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,16878147 0,19974826 ! vesicle docking GO:0048278 47 24 0,000 0,16878147 0,19965006 ! spinal cord development GO:0021510 47 24 0,000 0,16878147 0,19955195 ! vacuole organization GO:0007033 43 24 0,000 0,16878147 0,19945394 ! digestive system process GO:0022600 39 24 0,000 0,16878147 0,19935602 ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,16878147 0,1992582 ! membrane depolarization GO:0051899 39 24 0,000 0,16878147 0,19916048 ! pentose metabolic process GO:0019321 35 24 0,000 0,16878147 0,19906285 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,16878147 0,19896532 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,16878147 0,19886788 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,16878147 0,19877054 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,16878147 0,19867329 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,16878147 0,19857614 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,16878147 0,19847909 ! regulation of amine transport GO:0051952 40 24 0,000 0,16878147 0,19838213 ! protein tetramerization GO:0051262 52 24 0,000 0,16878147 0,19828526 ! protein ubiquitination GO:0016567 217 97 1,000 0,17073175 0,20047857 ! carboxylic acid catabolic process GO:0046395 156 98 1,000 0,17345916 0,20358183 GO:0016054|organic acid catabolic process, ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,17516207 0,20548023 ! phototransduction GO:0007602 33 25 0,000 0,17516207 0,20538009 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 0,000 0,17516207 0,20528005 ! sperm motility GO:0030317 31 25 0,000 0,17516207 0,20518011 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,17516207 0,20508026 ! receptor metabolic process GO:0043112 46 25 0,000 0,17516207 0,20498052 ! chromosome condensation GO:0030261 45 25 0,000 0,17516207 0,20488087 ! osteoblast differentiation GO:0001649 60 25 0,000 0,17516207 0,20478131 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,17516207 0,20468186 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,17516207 0,2045825 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,17516207 0,20448323 ! interaction with host GO:0051701 62 25 0,000 0,17516207 0,20438407 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,17516207 0,20428499 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,17516207 0,20418602 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,17516207 0,20408714 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,17516207 0,20398836 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,17516207 0,20388967 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,17516207 0,20379108 ! telomere organization GO:0032200 43 25 0,000 0,17516207 0,20369258 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,17516207 0,20359418 GO:0060606|tube closure, ! liver development GO:0001889 53 25 0,000 0,17516207 0,20349587 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,18149391 0,21075016 ! embryonic pattern specification GO:0009880 44 26 0,000 0,18149391 0,2106485 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,18149391 0,21054693 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,18149391 0,21044546 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,18149391 0,21034409 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,18149391 0,21024282 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,18149391 0,21014164 ! tube lumen formation GO:0035148 50 26 0,000 0,18149391 0,21004057 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,18149391 0,20993959 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,18149391 0,2098387 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,18149391 0,20973791 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,18149391 0,20963722 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,18149391 0,20953663 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,18149391 0,20943613 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,18149391 0,20933573 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,18149391 0,20923543 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,18149391 0,20913522 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,18149391 0,20903511 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,18149391 0,20893509 ! neuron fate commitment GO:0048663 48 27 0,000 0,18777734 0,21606518 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,18777734 0,2159619 ! iron ion transport GO:0006826 59 27 0,000 0,18777734 0,21585871 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,18777734 0,21575563 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,18777734 0,21565264 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,18777734 0,21554976 ! fat cell differentiation GO:0045444 50 27 0,000 0,18777734 0,21544697 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,18777734 0,21534427 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,18777734 0,21524168 ! primary neural tube formation GO:0014020 51 27 0,000 0,18777734 0,21513918 ! base-excision repair GO:0006284 41 27 0,000 0,18777734 0,21503679 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,18777734 0,21493448 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,18777734 0,21483228 ! glutathione metabolic process GO:0006749 39 27 0,000 0,18777734 0,21473017 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,18777734 0,21462816 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,18777734 0,21452625 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,19401275 0,2215447 ! circadian rhythm GO:0007623 50 28 0,000 0,19401275 0,2214396 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,19401275 0,2213346 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,19401275 0,22122971 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,19401275 0,22112491 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,19401275 0,22102021 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,19401275 0,22091561 ! synaptogenesis GO:0007416 42 28 0,000 0,19401275 0,22081111 ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,19401275 0,2207067 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,19401275 0,2206024 ! translational initiation GO:0006413 65 29 0,000 0,2002005 0,22753065 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,2002005 0,22742323 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,2002005 0,2273159 ! regulation of pH GO:0006885 43 29 0,000 0,2002005 0,22720868 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,2002005 0,22710155 ! catechol metabolic process GO:0009712 54 29 0,000 0,2002005 0,22699453 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,2002005 0,22688761 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,2002005 0,22678079 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,2002005 0,22667407 ! cell fate determination GO:0001709 60 29 0,000 0,2002005 0,22656745 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,2002005 0,22646093 ! detection of light stimulus GO:0009583 38 29 0,000 0,2002005 0,22635451 ! regulation of coagulation GO:0050818 46 29 0,000 0,2002005 0,22624819 ! phenol metabolic process GO:0018958 55 30 0,000 0,20634094 0,23307808 ! zinc ion transport GO:0006829 45 30 0,000 0,20634094 0,2329687 ! membrane docking GO:0022406 61 30 0,000 0,20634094 0,23285943 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,20634094 0,23275026 ! regulation of innate immune response GO:0045088 51 30 0,000 0,20634094 0,23264119 ! acute-phase response GO:0006953 49 30 0,000 0,20634094 0,23253223 ! myofibril assembly GO:0030239 47 30 0,000 0,20634094 0,23242336 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 47 30 0,000 0,20634094 0,2323146 ! phospholipid transport GO:0015914 51 30 0,000 0,20634094 0,23220594 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,20634094 0,23209738 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,20634094 0,23198893 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,20634094 0,23188057 ! eye morphogenesis GO:0048592 60 30 0,000 0,20634094 0,23177232 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,21243444 0,23850549 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,21243444 0,23839425 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,21243444 0,23828311 GO:0009799|determination of symmetry, ! inner ear morphogenesis GO:0042472 47 31 0,000 0,21243444 0,23817207 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,21243444 0,23806114 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,21243444 0,23795031 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,21243444 0,23783959 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,21243444 0,23772896 ! peptide transport GO:0015833 55 31 0,000 0,21243444 0,23761844 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,21243444 0,23750803 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,21243444 0,23739771 ! natural killer cell activation GO:0030101 45 31 0,000 0,21243444 0,2372875 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,21243444 0,23717739 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,21848136 0,24381547 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,21848136 0,24370244 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,21848136 0,24358951 ! cholesterol transport GO:0030301 56 32 0,000 0,21848136 0,24347668 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,21848136 0,24336396 ! spliceosome assembly GO:0000245 67 32 0,000 0,21848136 0,24325135 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,21848136 0,24313884 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,21848136 0,24302643 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,21848136 0,24291412 ! regulation of protein import into nucleus GO:0042306 63 32 0,000 0,21848136 0,24280192 ! muscle cell development GO:0055001 49 32 0,000 0,21848136 0,24268983 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,21848136 0,24257783 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,21848136 0,24246594 ! BMP signaling pathway GO:0030509 64 32 0,000 0,21848136 0,24235415 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,21848136 0,24224247 ! DNA damage checkpoint GO:0000077 71 33 0,000 0,22448206 0,24878113 ! protein targeting to membrane GO:0006612 68 33 0,000 0,22448206 0,24866659 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,22448206 0,24855215 ! ceramide metabolic process GO:0006672 64 33 0,000 0,22448206 0,24843782 ! sterol transport GO:0015918 57 33 0,000 0,22448206 0,2483236 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,22448206 0,24820948 ! negative regulation of protein transport GO:0051224 69 33 0,000 0,22448206 0,24809546 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,22448206 0,24798155 ! glial cell differentiation GO:0010001 63 34 0,000 0,23043687 0,25444291 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,23043687 0,2543262 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,23043687 0,25420959 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,23043687 0,25409308 ! mismatch repair GO:0006298 46 34 0,000 0,23043687 0,25397669 ! spermatid development GO:0007286 63 34 0,000 0,23043687 0,2538604 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,23043687 0,25374421 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,23043687 0,25362814 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,23043687 0,25351217 ! negative regulation of secretion GO:0051048 63 35 0,000 0,23634616 0,25989436 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,23634616 0,25977563 GO:0006639|acylglycerol metabolic process, ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,23634616 0,25965701 ! cytokine production GO:0001816 59 35 0,000 0,23634616 0,2595385 ! neural tube formation GO:0001841 67 35 0,000 0,23634616 0,2594201 ! vesicle localization GO:0051648 64 35 0,000 0,23634616 0,2593018 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,24221026 0,26561435 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,24221026 0,26549335 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,24221026 0,26537245 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,24221026 0,26525166 ! DNA integrity checkpoint GO:0031570 75 36 0,000 0,24221026 0,26513098 ! regulation of proteolysis GO:0030162 72 36 0,000 0,24221026 0,26501041 ! aerobic respiration GO:0009060 55 36 0,000 0,24221026 0,26488995 ! RNA export from nucleus GO:0006405 56 37 0,000 0,24802953 0,27113087 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,24802953 0,27100775 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,24802953 0,27088473 ! actomyosin structure organization GO:0031032 62 37 0,000 0,24802953 0,27076182 ! organic anion transport GO:0015711 68 37 0,000 0,24802953 0,27063903 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,24802953 0,27051634 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,24802953 0,27039377 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,24802953 0,27027131 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,24802953 0,27014896 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,24802953 0,27002672 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,25380431 0,27618867 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,25380431 0,27606382 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,25380431 0,27593907 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,25380431 0,27581443 ! mitotic cell cycle checkpoint GO:0007093 76 38 0,000 0,25380431 0,27568991 ! lipid homeostasis GO:0055088 67 38 0,000 0,25380431 0,2755655 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,25380431 0,27544121 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,25380431 0,27531702 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,25380431 0,27519295 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,25380431 0,27506899 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,25380431 0,27494514 ! mRNA catabolic process GO:0006402 71 39 0,000 0,25953492 0,28102656 ! organic ether metabolic process GO:0018904 55 39 0,000 0,25953492 0,28090014 ! ion transmembrane transport GO:0034220 66 39 0,000 0,25953492 0,28077384 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,25953492 0,28064765 ! RNA modification GO:0009451 57 39 0,000 0,25953492 0,28052157 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,25953492 0,28039561 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,26522172 0,28641088 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,26522172 0,28628239 ! feeding behavior GO:0007631 59 40 0,000 0,26522172 0,28615401 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,26522172 0,28602575 ! maintenance of protein location GO:0045185 91 40 0,000 0,26522172 0,2858976 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,27086503 0,29185009 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,27086503 0,29171945 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,27086503 0,29158893 ! gliogenesis GO:0042063 88 41 0,000 0,27086503 0,29145852 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,27086503 0,29132823 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,27086503 0,29119806 ! regulation of tube size GO:0035150 71 42 0,000 0,27646518 0,29708585 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,27646518 0,29695322 ! regulation of protein secretion GO:0050708 71 42 0,000 0,27646518 0,29682071 ! epithelial cell differentiation GO:0030855 79 43 0,000 0,2820225 0,30265216 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,2820225 0,30251723 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,2820225 0,30238242 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,2820225 0,30224772 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,2820225 0,30211315 ! neural tube development GO:0021915 77 43 0,000 0,2820225 0,3019787 ! striated muscle contraction GO:0006941 77 43 0,000 0,2820225 0,30184437 ! phagocytosis GO:0006909 90 43 0,000 0,2820225 0,30171016 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,2820225 0,30157606 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,28753733 0,30733665 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,28753733 0,30720018 ! maintenance of location in cell GO:0051651 97 44 0,000 0,28753733 0,30706383 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,29300997 0,3127693 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,29300997 0,3126306 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,29300997 0,31249202 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,29300997 0,31235356 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,29300997 0,31221523 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,29844076 0,31786121 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,29844076 0,31772056 ! response to calcium ion GO:0051592 81 47 0,000 0,30383001 0,32331491 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,30383001 0,32317198 ! JNK cascade GO:0007254 91 47 0,000 0,30383001 0,32302917 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,30383001 0,32288649 ! protein homooligomerization GO:0051260 76 47 0,000 0,30383001 0,32274393 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,30917804 0,32827995 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,30917804 0,32813514 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,30917804 0,32799046 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,30917804 0,32784591 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,31448517 0,33332657 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,31448517 0,33317979 ! regulation of ion transport GO:0043269 77 49 0,000 0,31448517 0,33303315 ! peptide metabolic process GO:0006518 76 49 0,000 0,31448517 0,33288663 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,31448517 0,33274024 ! endocrine system development GO:0035270 104 49 0,000 0,31448517 0,33259398 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,31448517 0,33244785 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,31448517 0,33230185 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,31448517 0,33215597 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,31975169 0,33757024 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,32497793 0,34293724 ! excretion GO:0007588 83 51 0,000 0,32497793 0,34278689 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,32497793 0,34263668 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,32497793 0,3424866 ! membrane fusion GO:0006944 110 52 0,000 0,33016419 0,34779993 ! amino acid activation GO:0043038 92 52 0,000 0,33016419 0,34764772 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 76 53 0,000 0,33531078 0,35291239 ! RNA catabolic process GO:0006401 93 53 0,000 0,33531078 0,35275808 ! regulation of translational initiation GO:0006446 82 53 0,000 0,33531078 0,3526039 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,33531078 0,35244986 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,33531078 0,35229595 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,33531078 0,35214218 ! cell maturation GO:0048469 100 53 0,000 0,33531078 0,35198854 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,33531078 0,35183503 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,34041799 0,35703822 ! cell recognition GO:0008037 85 54 0,000 0,34041799 0,35688265 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,34041799 0,35672721 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,34041799 0,35657191 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,34041799 0,35641675 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,34548613 0,36156573 ! regulation of protein catabolic process GO:0042176 116 55 0,000 0,34548613 0,36140853 ! RNA elongation GO:0006354 79 55 0,000 0,34548613 0,36125147 ! nuclear export GO:0051168 97 55 0,000 0,34548613 0,36109454 ! regulation of actin filament length GO:0030832 105 56 0,000 0,35051549 0,36619204 ! sensory perception of smell GO:0007608 80 56 0,000 0,35051549 0,3660331 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,35051549 0,3658743 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,35051549 0,36571564 ! proton transport GO:0015992 94 56 0,000 0,35051549 0,36555712 ! maintenance of location GO:0051235 118 57 0,000 0,35550637 0,37060153 ! hydrogen transport GO:0006818 97 58 0,000 0,36045907 0,37560178 ! regulation of endocytosis GO:0030100 91 58 0,000 0,36045907 0,37543919 ! positive regulation of secretion GO:0051047 95 59 0,000 0,36537387 0,38039356 ! regulation of cellular component size GO:0032535 109 59 0,000 0,36537387 0,38022903 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,36537387 0,38006465 GO:0032313|regulation of Rab GTPase activity, ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,37025106 0,3849715 ! DNA damage response, signal transduction GO:0042770 128 60 0,000 0,37025106 0,3848052 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,37025106 0,38463905 ! camera-type eye development GO:0043010 116 60 0,000 0,37025106 0,38447305 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,37509093 0,38933079 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,37509093 0,38916291 ! tRNA processing GO:0008033 89 61 0,000 0,37509093 0,38899516 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,37509093 0,38882757 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,37989377 0,39363669 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,38465985 0,39840361 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,38465985 0,39823218 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,38465985 0,3980609 ! cell redox homeostasis GO:0045454 102 64 0,000 0,38938945 0,40278204 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,38938945 0,40260895 ! single fertilization GO:0007338 75 64 0,000 0,38938945 0,40243601 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,39408286 0,40711179 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,39874035 0,41174647 ! extracellular matrix organization GO:0030198 133 66 0,000 0,39874035 0,41156983 ! cell projection assembly GO:0030031 120 66 0,000 0,39874035 0,41139335 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,40336219 0,41598347 ! amino acid transport GO:0006865 125 68 0,000 0,40794866 0,42053319 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,40794866 0,42035309 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,40794866 0,42017315 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,40794866 0,41999336 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,41250002 0,42449745 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,41250002 0,42431597 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,41250002 0,42413464 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,41250002 0,42395346 ! antigen processing and presentation GO:0019882 104 69 0,000 0,41250002 0,42377244 ! amine catabolic process GO:0009310 117 71 0,000 0,42149849 0,432832 ! acute inflammatory response GO:0002526 113 72 0,000 0,42594614 0,43721263 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,42594614 0,43702619 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,42594614 0,4368399 ! regulation of blood pressure GO:0008217 125 73 0,000 0,43035973 0,44117832 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,43035973 0,44099042 ! fertilization GO:0009566 90 73 0,000 0,43035973 0,44080269 ! transition metal ion transport GO:0000041 126 74 0,000 0,43473954 0,44509929 ! neurotransmitter transport GO:0006836 123 74 0,000 0,43473954 0,44490996 ! exocytosis GO:0006887 133 74 0,000 0,43473954 0,4447208 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,43473954 0,4445318 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,43473954 0,44434296 ! eye development GO:0001654 143 74 0,000 0,43473954 0,44415428 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,43908581 0,44840427 ! defense response to bacterium GO:0042742 89 76 0,000 0,44339881 0,45261669 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,44767879 0,45679185 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,44767879 0,45659821 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,44767879 0,45640474 ! blood coagulation GO:0007596 146 78 0,000 0,451926 0,46053959 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,451926 0,46034461 ! protein oligomerization GO:0051259 139 78 0,000 0,451926 0,4601498 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,4561407 0,46424472 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,4561407 0,46404842 ! regulation of adenylate cyclase activity GO:0045761 156 80 0,000 0,46032311 0,46810542 ! muscle cell differentiation GO:0042692 159 80 0,000 0,46032311 0,46790765 ! protein import into nucleus GO:0006606 158 80 0,000 0,46032311 0,46771006 ! digestion GO:0007586 112 81 0,000 0,46447351 0,47172784 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,46447351 0,4715288 ! nuclear import GO:0051170 161 81 0,000 0,46447351 0,47132993 ! regulation of cAMP biosynthetic process GO:0030817 161 82 0,000 0,46859212 0,47530887 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,46859212 0,47510857 ! regulation of cyclase activity GO:0031279 159 82 0,000 0,46859212 0,47490844 ! regulation of lyase activity GO:0051339 160 83 0,000 0,47267919 0,4788489 ! regulation of cAMP metabolic process GO:0030814 168 84 0,000 0,47673497 0,48275435 ! hemostasis GO:0007599 158 84 0,000 0,47673497 0,48255125 ! response to unfolded protein GO:0006986 131 85 0,000 0,48075968 0,48642043 ! nucleosome assembly GO:0006334 122 85 0,000 0,48075968 0,48621597 ! amine biosynthetic process GO:0009309 138 86 0,000 0,48475357 0,4900492 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,48475357 0,48984338 ! chromatin assembly GO:0031497 124 86 0,000 0,48475357 0,48963774 ! amine transport GO:0015837 155 86 0,000 0,48475357 0,48943226 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 0,000 0,48871687 0,49322684 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,48871687 0,49302004 ! protein localization in nucleus GO:0034504 176 87 0,000 0,48871687 0,49281341 ! cellular respiration GO:0045333 135 88 0,000 0,49264982 0,4965712 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,49264982 0,49636326 ! cellular defense response GO:0006968 114 89 0,000 0,49655264 0,50008608 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 0,000 0,50042557 0,5037757 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,50042557 0,503565 ! sterol metabolic process GO:0016125 152 91 0,000 0,50426884 0,50722024 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,50426884 0,50700828 ! nucleosome organization GO:0034728 138 92 0,000 0,50808266 0,51062944 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,50808266 0,51041623 ! vitamin metabolic process GO:0006766 139 92 0,000 0,50808266 0,51020321 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,51186727 0,51378917 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 0,000 0,51186727 0,51357492 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,51562289 0,51712741 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,51934973 0,52064811 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,52304803 0,52413726 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,52304803 0,52391905 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,52671799 0,52737557 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,53035983 0,53080107 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,53397377 0,5341958 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,53397377 0,53397377