pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6709-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 9,000 1,05E-11 2,565E-08 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 7,000 2,521E-11 3,08E-08 ! regulation of cell adhesion GO:0030155 241 92 9,000 1,405E-09 1,144E-06 ! negative regulation of cell adhesion GO:0007162 94 37 6,000 8,146E-09 4,975E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 4,000 8,475E-09 4,141E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of protein stability GO:0031647 77 38 6,000 9,924E-09 4,041E-06 ! regulation of cell-matrix adhesion GO:0001952 81 23 5,000 1,227E-08 4,283E-06 GO:0010810|regulation of cell-substrate adhesion, ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,328E-08 4,054E-06 ! negative regulation of phosphorylation GO:0042326 52 24 5,000 1,627E-08 4,415E-06 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 5,000 2,749E-08 6,715E-06 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 7,000 3,828E-08 8,501E-06 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 3,96E-08 8,062E-06 ! negative regulation of cell migration GO:0030336 122 46 6,000 4,006E-08 7,529E-06 ! cell growth GO:0016049 90 46 6,000 4,006E-08 6,991E-06 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 9,187E-08 1,496E-05 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 4,000 1,096E-07 1,673E-05 ! negative regulation of cell motion GO:0051271 142 55 6,000 1,437E-07 2,065E-05 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 1,827E-07 2,48E-05 ! induction of positive chemotaxis GO:0050930 17 9 3,000 3,27E-07 4,204E-05 ! positive regulation of locomotion GO:0040017 44 22 4,000 4,527E-07 5,529E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 5,419E-07 6,304E-05 ! regulation of chemotaxis GO:0050920 45 23 4,000 5,75E-07 6,385E-05 ! interphase of mitotic cell cycle GO:0051329 224 98 7,000 6,015E-07 6,389E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 3,000 8,467E-07 8,618E-05 ! regulation of epithelial cell proliferation GO:0050678 122 45 5,000 8,668E-07 8,47E-05 ! regulation of behavior GO:0050795 48 25 4,000 8,972E-07 8,43E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 9,908E-07 8,965E-05 ! regulation of B cell proliferation GO:0030888 22 12 3,000 1,263E-06 1,102E-04 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 1,263E-06 1,064E-04 GO:0050927|positive regulation of positive chemotaxis, ! embryonic placenta development GO:0001892 21 12 3,000 1,263E-06 1,028E-04 ! negative regulation of protein modification process GO:0031400 66 28 4,000 1,63E-06 1,285E-04 ! positive regulation of phosphorylation GO:0042327 149 81 6,000 2,099E-06 1,602E-04 ! cartilage development GO:0051216 99 53 5,000 2,328E-06 1,723E-04 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 6,000 2,476E-06 1,779E-04 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 3,000 2,525E-06 1,762E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 3,000 3,423E-06 2,323E-04 ! positive regulation of cell migration GO:0030335 137 58 5,000 3,982E-06 2,629E-04 ! regulation of cell cycle process GO:0010564 161 90 6,000 4,267E-06 2,743E-04 ! regulation of protein ubiquitination GO:0031396 28 16 3,000 4,538E-06 2,843E-04 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 3,000 4,538E-06 2,772E-04 ! lipid modification GO:0030258 112 60 5,000 4,866E-06 2,899E-04 ! placenta development GO:0001890 53 35 4,000 5,168E-06 3,006E-04 ! endothelial cell migration GO:0043542 31 17 3,000 5,901E-06 3,353E-04 ! cardiac muscle tissue development GO:0048738 34 17 3,000 5,901E-06 3,276E-04 ! regulation of homeostatic process GO:0032844 148 62 5,000 5,903E-06 3,205E-04 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 2,000 7,353E-06 3,905E-04 ! neural nucleus development GO:0048857 19 6 2,000 7,353E-06 3,822E-04 ! maternal placenta development GO:0001893 12 6 2,000 7,353E-06 3,743E-04 ! forebrain development GO:0030900 210 98 6,000 7,523E-06 3,751E-04 ! positive regulation of cell motion GO:0051272 157 65 5,000 7,79E-06 3,806E-04 ! inositol metabolic process GO:0006020 33 19 3,000 9,501E-06 4,551E-04 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 3,000 9,501E-06 4,464E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 5,000 1,104E-05 5,087E-04 ! mesenchymal cell development GO:0014031 94 41 4,000 1,151E-05 5,209E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 1,181E-05 5,246E-04 ! negative regulation of kinase activity GO:0033673 145 70 5,000 1,2E-05 5,234E-04 ! positive regulation of protein ubiquitination GO:0031398 14 7 2,000 1,28E-05 5,486E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 1,28E-05 5,391E-04 ! regulation of T cell differentiation GO:0045580 78 42 4,000 1,299E-05 5,38E-04 ! C21-steroid hormone metabolic process GO:0008207 38 21 3,000 1,451E-05 5,906E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 1,639E-05 6,566E-04 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 5,000 1,655E-05 6,52E-04 ! negative regulation of transferase activity GO:0051348 155 74 5,000 1,655E-05 6,417E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 1,834E-05 6,999E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 2,037E-05 7,656E-04 ! dendrite morphogenesis GO:0048813 14 8 2,000 2,037E-05 7,54E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 2,037E-05 7,427E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,037E-05 7,318E-04 ! sex determination GO:0007530 48 24 3,000 2,532E-05 8,964E-04 ! response to hypoxia GO:0001666 178 81 5,000 2,779E-05 9,699E-04 ! regulation of lymphocyte differentiation GO:0045619 92 49 4,000 2,795E-05 9,617E-04 ! regulation of mast cell proliferation GO:0070666 89 49 4,000 2,795E-05 9,484E-04 ! lymphocyte proliferation GO:0046651 55 25 3,000 2,997E-05 1,003E-03 ! T cell selection GO:0045058 27 9 2,000 3,039E-05 1,003E-03 ! axon extension GO:0048675 16 9 2,000 3,039E-05 9,899E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 3,039E-05 9,769E-04 ! response to oxygen levels GO:0070482 183 83 5,000 3,194E-05 1,013E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 4,000 4,108E-05 1,287E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! leukocyte proliferation GO:0070661 59 27 3,000 4,111E-05 1,271E-03 GO:0032943|mononuclear cell proliferation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 4,318E-05 1,319E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 2,000 4,318E-05 1,302E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 4,318E-05 1,287E-03 ! negative regulation of striated muscle development GO:0045843 26 10 2,000 4,318E-05 1,271E-03 ! central nervous system neuron axonogenesis GO:0021955 23 10 2,000 4,318E-05 1,256E-03 GO:0021952|central nervous system projection neuron axonogenesis, ! motor axon guidance GO:0008045 22 10 2,000 4,318E-05 1,241E-03 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 4,318E-05 1,227E-03 ! protein sumoylation GO:0016925 17 10 2,000 4,318E-05 1,213E-03 ! blastocyst formation GO:0001825 18 10 2,000 4,318E-05 1,199E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 4,318E-05 1,185E-03 ! dendrite development GO:0016358 67 28 3,000 4,769E-05 1,294E-03 ! positive regulation of protein modification process GO:0031401 156 90 5,000 5,051E-05 1,356E-03 ! negative regulation of muscle development GO:0048635 27 11 2,000 5,906E-05 1,568E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 2,000 5,906E-05 1,551E-03 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 5,906E-05 1,535E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 5,906E-05 1,519E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 2,000 5,906E-05 1,503E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 5,906E-05 1,487E-03 GO:0010829|negative regulation of glucose transport, ! positive regulation of MAP kinase activity GO:0043406 174 93 5,000 6,073E-05 1,514E-03 ! negative regulation of protein kinase cascade GO:0010741 72 30 3,000 6,311E-05 1,557E-03 ! regulation of B cell activation GO:0050864 55 30 3,000 6,311E-05 1,542E-03 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 7,685E-05 1,859E-03 ! hippocampus development GO:0021766 29 12 2,000 7,832E-05 1,876E-03 ! T cell proliferation GO:0042098 32 12 2,000 7,832E-05 1,858E-03 ! focal adhesion formation GO:0048041 37 12 2,000 7,832E-05 1,84E-03 ! regulation of leukocyte migration GO:0002685 29 12 2,000 7,832E-05 1,822E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 7,832E-05 1,805E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of mitosis GO:0007088 112 63 4,000 9,489E-05 2,166E-03 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 4,000 9,489E-05 2,146E-03 ! cartilage condensation GO:0001502 22 13 2,000 1,013E-04 2,27E-03 ! regulation of monooxygenase activity GO:0032768 35 13 2,000 1,013E-04 2,249E-03 ! regulation of striated muscle tissue development GO:0016202 81 35 3,000 1,172E-04 2,579E-03 ! ear development GO:0043583 114 66 4,000 1,185E-04 2,586E-03 ! T cell differentiation in the thymus GO:0033077 37 14 2,000 1,282E-04 2,772E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 1,282E-04 2,748E-03 ! regulation of muscle development GO:0048634 82 36 3,000 1,311E-04 2,785E-03 ! hormone biosynthetic process GO:0042446 62 37 3,000 1,462E-04 3,078E-03 ! androgen receptor signaling pathway GO:0030521 81 37 3,000 1,462E-04 3,052E-03 ! negative regulation of bone remodeling GO:0046851 34 15 2,000 1,594E-04 3,3E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 1,594E-04 3,273E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 2,000 1,951E-04 3,973E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,951E-04 3,94E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! cell-matrix adhesion GO:0007160 181 76 4,000 2,311E-04 4,627E-03 ! negative regulation of microtubule depolymerization GO:0007026 50 17 2,000 2,357E-04 4,681E-03 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 2,000 2,357E-04 4,644E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 2,357E-04 4,606E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 2,357E-04 4,57E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 2,357E-04 4,534E-03 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 2,457E-04 4,689E-03 ! regulation of T cell proliferation GO:0042129 80 43 3,000 2,64E-04 4,999E-03 ! neuron migration GO:0001764 85 43 3,000 2,64E-04 4,961E-03 ! limbic system development GO:0021761 40 18 2,000 2,813E-04 5,246E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 2,813E-04 5,207E-03 ! defense response to virus GO:0051607 43 18 2,000 2,813E-04 5,168E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 2,000 2,813E-04 5,129E-03 ! polyol metabolic process GO:0019751 77 45 3,000 3,151E-04 5,703E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 3,295E-04 5,919E-03 ! G1 phase of mitotic cell cycle GO:0000080 39 19 2,000 3,323E-04 5,926E-03 ! cellular pigmentation GO:0033059 37 19 2,000 3,323E-04 5,883E-03 ! pigmentation GO:0043473 103 46 3,000 3,432E-04 6,032E-03 ! T cell activation GO:0042110 189 84 4,000 3,685E-04 6,43E-03 ! response to alkaloid GO:0043279 38 20 2,000 3,889E-04 6,737E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 3,889E-04 6,69E-03 ! regulation of glucose import GO:0046324 30 20 2,000 3,889E-04 6,643E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 3,889E-04 6,597E-03 ! negative regulation of growth GO:0045926 168 85 4,000 3,892E-04 6,557E-03 ! JAK-STAT cascade GO:0007259 82 48 3,000 4,046E-04 6,77E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 4,512E-04 7,499E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 4,512E-04 7,449E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 5,109E-04 8,377E-03 ! negative regulation of protein ubiquitination GO:0031397 10 5 1,000 5,133E-04 8,361E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 5,133E-04 8,305E-03 GO:0045844|positive regulation of striated muscle development, ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 5,133E-04 8,251E-03 ! monocyte activation GO:0042117 10 5 1,000 5,133E-04 8,197E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 5,133E-04 8,144E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 5,133E-04 8,091E-03 ! negative regulation of T cell mediated immunity GO:0002710 15 5 1,000 5,133E-04 8,039E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! decidualization GO:0046697 11 5 1,000 5,133E-04 7,988E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 5,133E-04 7,937E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 1,000 5,133E-04 7,887E-03 ! B cell homeostasis GO:0001782 13 5 1,000 5,133E-04 7,838E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 1,000 5,133E-04 7,789E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 5,133E-04 7,741E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 5,133E-04 7,694E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 5,133E-04 7,647E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 5,133E-04 7,601E-03 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 1,000 5,133E-04 7,555E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 1,000 5,133E-04 7,51E-03 ! stem cell division GO:0017145 11 5 1,000 5,133E-04 7,465E-03 GO:0048103|somatic stem cell division, ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 5,133E-04 7,421E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,133E-04 7,377E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 5,133E-04 7,334E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 5,133E-04 7,291E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 5,133E-04 7,249E-03 ! valine metabolic process GO:0006573 12 5 1,000 5,133E-04 7,207E-03 ! response to tumor necrosis factor GO:0034612 10 5 1,000 5,133E-04 7,166E-03 ! mRNA transcription GO:0009299 10 5 1,000 5,133E-04 7,126E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 5,133E-04 7,085E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 5,133E-04 7,046E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 5,133E-04 7,006E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 5,197E-04 7,054E-03 ! central nervous system neuron development GO:0021954 47 22 2,000 5,197E-04 7,015E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 5,197E-04 6,976E-03 ! G1 phase GO:0051318 44 22 2,000 5,197E-04 6,938E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 5,197E-04 6,9E-03 ! positive regulation of B cell activation GO:0050871 42 22 2,000 5,197E-04 6,863E-03 ! response to cytokine stimulus GO:0034097 69 22 2,000 5,197E-04 6,826E-03 ! inner ear receptor cell differentiation GO:0060113 42 22 2,000 5,197E-04 6,79E-03 ! gland development GO:0048732 220 91 4,000 5,328E-04 6,923E-03 ! histone modification GO:0016570 104 52 3,000 5,504E-04 7,114E-03 ! positive regulation of growth GO:0045927 96 53 3,000 5,919E-04 7,611E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 3,000 5,919E-04 7,571E-03 ! vesicle organization GO:0016050 127 53 3,000 5,919E-04 7,532E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 5,945E-04 7,525E-03 ! covalent chromatin modification GO:0016569 115 54 3,000 6,357E-04 8,005E-03 ! regulation of cell shape GO:0008360 142 54 3,000 6,357E-04 7,964E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 6,758E-04 8,423E-03 ! mechanoreceptor differentiation GO:0042490 48 24 2,000 6,758E-04 8,381E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 6,758E-04 8,338E-03 ! central nervous system neuron differentiation GO:0021953 51 24 2,000 6,758E-04 8,296E-03 ! pallium development GO:0021543 56 24 2,000 6,758E-04 8,255E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 6,758E-04 8,214E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 6,758E-04 8,173E-03 ! regulation of T cell activation GO:0050863 175 96 4,000 6,801E-04 8,184E-03 ! response to UV GO:0009411 120 55 3,000 6,817E-04 8,163E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 7,468E-04 8,9E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 7,639E-04 9,059E-03 ! vasculogenesis GO:0001570 49 25 2,000 7,639E-04 9,015E-03 ! regulation of alpha-beta T cell activation GO:0046634 48 25 2,000 7,639E-04 8,972E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 7,663E-04 8,958E-03 ! thymic T cell selection GO:0045061 16 6 1,000 7,663E-04 8,915E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 1,000 7,663E-04 8,873E-03 ! paraxial mesoderm development GO:0048339 16 6 1,000 7,663E-04 8,831E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 7,663E-04 8,79E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 7,663E-04 8,748E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 7,663E-04 8,708E-03 GO:0045686|negative regulation of glial cell differentiation, ! DNA catabolic process, exonucleolytic GO:0000738 8 6 1,000 7,663E-04 8,667E-03 ! negative regulation of cell-cell adhesion GO:0022408 13 6 1,000 7,663E-04 8,628E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 7,663E-04 8,588E-03 ! regulation of interleukin-13 production GO:0032656 12 6 1,000 7,663E-04 8,549E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 7,663E-04 8,51E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 7,663E-04 8,471E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 7,663E-04 8,433E-03 GO:0043011|myeloid dendritic cell differentiation, ! negative regulation of B cell activation GO:0050869 14 6 1,000 7,663E-04 8,395E-03 ! blastocyst development GO:0001824 50 26 2,000 8,589E-04 9,367E-03 ! DNA catabolic process GO:0006308 94 60 3,000 9,475E-04 0,01028814 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 2,000 9,611E-04 0,01038948 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 9,611E-04 0,01034371 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 9,611E-04 0,01029834 ! cellular response to oxidative stress GO:0034599 43 27 2,000 9,611E-04 0,01025337 ! regulation of chromosome organization GO:0033044 49 27 2,000 9,611E-04 0,01020879 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 9,611E-04 0,0101646 ! negative regulation of response to stimulus GO:0048585 106 61 3,000 1,008E-03 0,01061786 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 1,068E-03 0,01119542 ! prostate gland development GO:0030850 14 7 1,000 1,068E-03 0,01114758 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,068E-03 0,01110014 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,068E-03 0,01105311 ! mRNA stabilization GO:0048255 18 7 1,000 1,068E-03 0,01100647 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 1,068E-03 0,01096022 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,068E-03 0,01091436 ! positive regulation of isotype switching GO:0045830 17 7 1,000 1,068E-03 0,01086889 GO:0045911|positive regulation of DNA recombination, ! organ growth GO:0035265 15 7 1,000 1,068E-03 0,01082379 ! B cell lineage commitment GO:0002326 21 7 1,000 1,068E-03 0,01077906 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 1,068E-03 0,0107347 ! regulation of interleukin-10 production GO:0032653 13 7 1,000 1,068E-03 0,01069071 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 1,068E-03 0,01064707 ! T cell lineage commitment GO:0002360 16 7 1,000 1,068E-03 0,01060379 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 1,000 1,068E-03 0,01056086 GO:0002714|positive regulation of B cell mediated immunity, ! peptidyl-threonine modification GO:0018210 26 7 1,000 1,068E-03 0,01051828 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 1,068E-03 0,01047604 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 1,000 1,068E-03 0,01043413 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 1,188E-03 0,01156225 ! somitogenesis GO:0001756 52 29 2,000 1,188E-03 0,01151636 ! integrin-mediated signaling pathway GO:0007229 160 64 3,000 1,207E-03 0,01165579 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 1,207E-03 0,0116099 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 1,313E-03 0,01257824 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 1,354E-03 0,01292007 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,417E-03 0,0134687 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 1,417E-03 0,0134165 ! succinate metabolic process GO:0006105 17 8 1,000 1,417E-03 0,0133647 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,417E-03 0,0133133 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,417E-03 0,01326229 ! hemoglobin metabolic process GO:0020027 14 8 1,000 1,417E-03 0,01321167 ! pigment granule organization GO:0048753 17 8 1,000 1,417E-03 0,01316143 ! ER overload response GO:0006983 13 8 1,000 1,417E-03 0,01311158 ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,417E-03 0,0130621 ! melanin metabolic process GO:0006582 17 8 1,000 1,417E-03 0,013013 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,417E-03 0,01296426 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,417E-03 0,01291588 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 1,417E-03 0,01286787 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,417E-03 0,01282021 ! response to UV-B GO:0010224 17 8 1,000 1,417E-03 0,0127729 ! regulation of interleukin-4 production GO:0032673 18 8 1,000 1,417E-03 0,01272594 ! gas homeostasis GO:0033483 14 8 1,000 1,417E-03 0,01267933 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 1,417E-03 0,01263305 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 1,417E-03 0,01258712 GO:0002688|regulation of leukocyte chemotaxis, ! trophectodermal cell differentiation GO:0001829 13 8 1,000 1,417E-03 0,01254151 ! B cell receptor signaling pathway GO:0050853 22 8 1,000 1,417E-03 0,01249623 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 1,000 1,417E-03 0,01245128 ! negative regulation of cell growth GO:0030308 142 67 3,000 1,432E-03 0,01253688 ! activation of MAPK activity GO:0000187 124 67 3,000 1,432E-03 0,0124921 ! cell junction assembly GO:0034329 85 31 2,000 1,446E-03 0,01257028 ! iron ion homeostasis GO:0055072 60 31 2,000 1,446E-03 0,01252571 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 1,446E-03 0,01248145 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 1,446E-03 0,0124375 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 1,446E-03 0,01239386 ! hindbrain development GO:0030902 65 32 2,000 1,587E-03 0,01355582 ! myeloid leukocyte activation GO:0002274 53 32 2,000 1,587E-03 0,01350859 ! negative regulation of cell size GO:0045792 144 69 3,000 1,597E-03 0,01354491 ! cellular hormone metabolic process GO:0034754 120 69 3,000 1,597E-03 0,01349804 ! lung development GO:0030324 165 69 3,000 1,597E-03 0,0134515 ! leukocyte chemotaxis GO:0030595 55 33 2,000 1,736E-03 0,01457742 GO:0060326|cell chemotaxis, ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,775E-03 0,01484692 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,813E-03 0,01511683 ! regulation of glycolysis GO:0006110 20 9 1,000 1,813E-03 0,01506541 ! microtubule bundle formation GO:0001578 22 9 1,000 1,813E-03 0,01501435 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,813E-03 0,01496362 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,813E-03 0,01491324 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 1,000 1,813E-03 0,01486319 GO:0002820|negative regulation of adaptive immune response, ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,813E-03 0,01481348 ! respiratory tube development GO:0030323 171 72 3,000 1,868E-03 0,01521524 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 1,894E-03 0,01537498 ! telencephalon development GO:0021537 81 35 2,000 2,061E-03 0,01667182 ! respiratory system development GO:0060541 175 74 3,000 2,066E-03 0,01666024 ! autophagic vacuole formation GO:0000045 17 10 1,000 2,255E-03 0,01812555 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 1,000 2,255E-03 0,01806612 ! lung alveolus development GO:0048286 26 10 1,000 2,255E-03 0,01800708 ! phosphagen metabolic process GO:0006599 17 10 1,000 2,255E-03 0,01794842 GO:0006600|creatine metabolic process, ! B cell proliferation GO:0042100 19 10 1,000 2,255E-03 0,01789015 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 2,255E-03 0,01783225 ! regulation of bone resorption GO:0045124 25 10 1,000 2,255E-03 0,01777473 ! regulation of gliogenesis GO:0014013 23 10 1,000 2,255E-03 0,01771758 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 2,255E-03 0,01766079 ! regulation of B cell differentiation GO:0045577 24 10 1,000 2,255E-03 0,01760436 ! induction of an organ GO:0001759 17 10 1,000 2,255E-03 0,0175483 ! synaptic vesicle endocytosis GO:0048488 23 10 1,000 2,255E-03 0,01749259 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 2,255E-03 0,01743723 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 2,255E-03 0,01738223 ! negative regulation of immune effector process GO:0002698 23 10 1,000 2,255E-03 0,01732757 ! lymphocyte differentiation GO:0030098 193 76 3,000 2,278E-03 0,0174476 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 2,000 2,421E-03 0,01848143 ! cell junction organization GO:0034330 96 37 2,000 2,421E-03 0,01842385 ! tissue remodeling GO:0048771 78 37 2,000 2,421E-03 0,01836663 ! regulation of microtubule-based process GO:0032886 86 37 2,000 2,421E-03 0,01830977 ! negative regulation of cell activation GO:0050866 69 37 2,000 2,421E-03 0,01825326 ! odontogenesis GO:0042476 74 37 2,000 2,421E-03 0,0181971 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 2,614E-03 0,01959191 ! steroid biosynthetic process GO:0006694 146 79 3,000 2,624E-03 0,01960008 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,744E-03 0,02043471 ! blood vessel remodeling GO:0001974 30 11 1,000 2,744E-03 0,0203726 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,744E-03 0,02031086 ! macroautophagy GO:0016236 19 11 1,000 2,744E-03 0,0202495 ! behavioral fear response GO:0001662 27 11 1,000 2,744E-03 0,02018851 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 2,744E-03 0,02012788 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 2,744E-03 0,02006762 ! alpha-beta T cell activation GO:0046631 26 11 1,000 2,744E-03 0,02000772 ! positive regulation of T cell mediated immunity GO:0002711 26 11 1,000 2,744E-03 0,01994817 ! DNA methylation GO:0006306 19 11 1,000 2,744E-03 0,01988898 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 25 11 1,000 2,744E-03 0,01983013 ! regulation of isotype switching GO:0045191 24 11 1,000 2,744E-03 0,01977164 ! apical protein localization GO:0045176 18 11 1,000 2,744E-03 0,01971348 ! thymus development GO:0048538 29 11 1,000 2,744E-03 0,01965567 ! oocyte development GO:0048599 20 11 1,000 2,744E-03 0,0195982 ! germ cell migration GO:0008354 26 11 1,000 2,744E-03 0,01954106 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 2,744E-03 0,01948426 ! regulation of embryonic development GO:0045995 35 11 1,000 2,744E-03 0,01942778 ! negative regulation of organelle organization GO:0010639 181 80 3,000 2,746E-03 0,01938956 ! negative regulation of binding GO:0051100 71 39 2,000 2,817E-03 0,01983449 ! positive regulation of leukocyte proliferation GO:0070665 70 39 2,000 2,817E-03 0,0197775 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 2,000 3,03E-03 0,02120696 ! nucleus organization GO:0006997 73 40 2,000 3,03E-03 0,02114637 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 3,251E-03 0,02263043 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 3,277E-03 0,022741 ! cranial nerve development GO:0021545 23 12 1,000 3,277E-03 0,02267658 ! histone acetylation GO:0016573 27 12 1,000 3,277E-03 0,02261252 ! autonomic nervous system development GO:0048483 24 12 1,000 3,277E-03 0,02254882 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 3,277E-03 0,02248548 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,277E-03 0,0224225 ! T cell homeostasis GO:0043029 28 12 1,000 3,277E-03 0,02235987 ! oocyte differentiation GO:0009994 21 12 1,000 3,277E-03 0,02229758 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 3,277E-03 0,02223565 ! developmental induction GO:0031128 22 12 1,000 3,277E-03 0,02217405 GO:0045168|cell-cell signaling involved in cell fate specification, ! localization within membrane GO:0051668 26 12 1,000 3,277E-03 0,0221128 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 3,418E-03 0,02300617 ! T cell differentiation GO:0030217 93 42 2,000 3,483E-03 0,02337652 ! cytokinesis GO:0000910 84 42 2,000 3,483E-03 0,02331248 ! mitochondrion organization GO:0007005 159 87 3,000 3,716E-03 0,02480433 ! segmentation GO:0035282 78 43 2,000 3,724E-03 0,02479255 ! regulation of chemokine production GO:0032642 18 13 1,000 3,854E-03 0,02558498 ! positive regulation of cell growth GO:0030307 24 13 1,000 3,854E-03 0,02551564 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 1,000 3,854E-03 0,02544668 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 3,854E-03 0,02537809 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 3,854E-03 0,02530987 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,854E-03 0,02524201 ! asymmetric protein localization GO:0008105 24 13 1,000 3,854E-03 0,02517452 ! membrane protein proteolysis GO:0033619 33 13 1,000 3,854E-03 0,02510739 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of DNA repair GO:0006282 23 13 1,000 3,854E-03 0,02504061 ! histone methylation GO:0016571 29 13 1,000 3,854E-03 0,02497419 ! chromatin silencing GO:0006342 29 13 1,000 3,854E-03 0,02490812 ! gland morphogenesis GO:0022612 31 13 1,000 3,854E-03 0,0248424 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 3,854E-03 0,02477703 ! spleen development GO:0048536 24 13 1,000 3,854E-03 0,024712 ! regulation of mRNA stability GO:0043488 32 13 1,000 3,854E-03 0,02464731 ! digestive tract morphogenesis GO:0048546 31 13 1,000 3,854E-03 0,02458295 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! one-carbon metabolic process GO:0006730 167 88 3,000 3,871E-03 0,02462904 ! response to reactive oxygen species GO:0000302 75 44 2,000 3,976E-03 0,02522863 ! negative regulation of protein complex disassembly GO:0043242 113 44 2,000 3,976E-03 0,02516327 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 4,237E-03 0,02674889 ! biopolymer methylation GO:0043414 91 45 2,000 4,237E-03 0,02667995 ! B cell differentiation GO:0030183 124 45 2,000 4,237E-03 0,02661136 ! ossification GO:0001503 205 91 3,000 4,363E-03 0,027331 ! regulation of S phase GO:0033261 26 14 1,000 4,475E-03 0,0279598 ! hair follicle morphogenesis GO:0031069 27 14 1,000 4,475E-03 0,02788847 ! fear response GO:0042596 34 14 1,000 4,475E-03 0,02781751 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 4,475E-03 0,0277469 GO:0060675|ureteric bud morphogenesis, ! response to gamma radiation GO:0010332 30 14 1,000 4,475E-03 0,02767666 ! regulation of RNA stability GO:0043487 33 14 1,000 4,475E-03 0,02760677 ! glycolysis GO:0006096 71 46 2,000 4,509E-03 0,02774697 ! leukocyte migration GO:0050900 75 46 2,000 4,509E-03 0,02767725 ! bone development GO:0060348 206 92 3,000 4,536E-03 0,02777293 ! regulation of cell morphogenesis GO:0022604 243 93 3,000 4,713E-03 0,02878706 ! response to insulin stimulus GO:0032868 98 47 2,000 4,791E-03 0,02918822 ! positive regulation of cell cycle GO:0045787 96 48 2,000 5,083E-03 0,03089273 ! positive regulation of defense response GO:0031349 88 48 2,000 5,083E-03 0,03081607 ! cellular component disassembly GO:0022411 89 48 2,000 5,083E-03 0,0307398 ! endosome transport GO:0016197 127 48 2,000 5,083E-03 0,0306639 ! regulation of inflammatory response GO:0050727 84 48 2,000 5,083E-03 0,03058837 ! methylation GO:0032259 97 48 2,000 5,083E-03 0,03051321 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 5,139E-03 0,03077024 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 5,139E-03 0,03069501 ! regulation of cell-cell adhesion GO:0022407 35 15 1,000 5,139E-03 0,03062014 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 5,139E-03 0,03054564 ! histone deacetylation GO:0016575 24 15 1,000 5,139E-03 0,0304715 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 5,139E-03 0,03039772 ! muscle maintenance GO:0046716 26 15 1,000 5,139E-03 0,03032429 ! lymphocyte homeostasis GO:0002260 33 15 1,000 5,139E-03 0,03025122 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 5,7E-03 0,03347382 ! activation of caspase activity GO:0006919 95 50 2,000 5,7E-03 0,03339354 ! regulation of gene expression, epigenetic GO:0040029 116 50 2,000 5,7E-03 0,03331365 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,845E-03 0,03408023 ! positive regulation of cell size GO:0045793 29 16 1,000 5,845E-03 0,03399909 ! embryonic hindlimb morphogenesis GO:0035116 36 16 1,000 5,845E-03 0,03391833 ! startle response GO:0001964 28 16 1,000 5,845E-03 0,03383796 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 1,000 5,845E-03 0,03375796 ! protein polyubiquitination GO:0000209 41 16 1,000 5,845E-03 0,03367834 ! stem cell development GO:0048864 46 16 1,000 5,845E-03 0,0335991 GO:0019827|stem cell maintenance, ! negative regulation of immune response GO:0050777 38 16 1,000 5,845E-03 0,03352023 ! regulation of T-helper cell differentiation GO:0045622 30 16 1,000 5,845E-03 0,03344173 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 1,000 5,845E-03 0,03336359 ! hormone metabolic process GO:0042445 171 100 3,000 6,087E-03 0,03466446 ! Notch signaling pathway GO:0007219 111 52 2,000 6,359E-03 0,03613062 ! regulation of protein complex disassembly GO:0043244 127 52 2,000 6,359E-03 0,03604679 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 6,359E-03 0,03596335 ! positive regulation of cell killing GO:0031343 36 17 1,000 6,593E-03 0,03719813 ! metencephalon development GO:0022037 32 17 1,000 6,593E-03 0,03711242 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 6,593E-03 0,03702711 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 1,000 6,593E-03 0,03694218 ! regulation of survival gene product expression GO:0045884 38 17 1,000 6,593E-03 0,03685765 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 1,000 6,593E-03 0,0367735 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 1,000 6,593E-03 0,03668973 GO:0002712|regulation of B cell mediated immunity, ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 6,593E-03 0,03660634 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 6,593E-03 0,03652334 ! inner ear development GO:0048839 89 53 2,000 6,706E-03 0,03706238 ! chromatin remodeling GO:0006338 122 53 2,000 6,706E-03 0,03697872 ! regulation of angiogenesis GO:0045765 125 54 2,000 7,063E-03 0,03886001 ! regulation of muscle contraction GO:0006937 94 54 2,000 7,063E-03 0,03877268 ! patterning of blood vessels GO:0001569 43 18 1,000 7,382E-03 0,04043549 ! heart looping GO:0001947 34 18 1,000 7,382E-03 0,04034503 ! regulation of viral genome replication GO:0045069 30 18 1,000 7,382E-03 0,04025498 ! epidermis morphogenesis GO:0048730 43 18 1,000 7,382E-03 0,04016532 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 7,382E-03 0,04007607 ! neural crest cell migration GO:0001755 41 18 1,000 7,382E-03 0,03998721 ! regulation of immunoglobulin production GO:0002637 49 18 1,000 7,382E-03 0,03989874 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 7,382E-03 0,03981066 ! nerve development GO:0021675 34 18 1,000 7,382E-03 0,03972297 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 7,431E-03 0,0398971 ! negative regulation of cytoskeleton organization GO:0051494 139 56 2,000 7,81E-03 0,04184161 ! glucose catabolic process GO:0006007 88 56 2,000 7,81E-03 0,04175005 ! regulation of DNA replication GO:0006275 105 56 2,000 7,81E-03 0,0416589 ! regulation of bone remodeling GO:0046850 143 57 2,000 8,2E-03 0,04364664 ! positive regulation of caspase activity GO:0043280 108 57 2,000 8,2E-03 0,04355176 GO:0010952|positive regulation of peptidase activity, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 1,000 8,211E-03 0,04351496 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 8,211E-03 0,04342078 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 8,211E-03 0,04332699 ! neuromuscular junction development GO:0007528 43 19 1,000 8,211E-03 0,04323362 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 8,211E-03 0,04314064 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 1,000 8,211E-03 0,04304806 ! aging GO:0007568 112 58 2,000 8,602E-03 0,04500098 ! regulation of tissue remodeling GO:0034103 146 58 2,000 8,602E-03 0,04490483 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 9,081E-03 0,04730017 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 9,081E-03 0,04719953 ! protein amino acid deacetylation GO:0006476 34 20 1,000 9,081E-03 0,04709932 ! protein amino acid acetylation GO:0006473 41 20 1,000 9,081E-03 0,04699953 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 9,081E-03 0,04690017 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 9,081E-03 0,04680122 GO:0010675|regulation of cellular carbohydrate metabolic process, ! actin filament bundle formation GO:0051017 47 20 1,000 9,081E-03 0,04670269 ! fatty acid beta-oxidation GO:0006635 36 20 1,000 9,081E-03 0,04660458 ! regulation of interleukin-2 production GO:0032663 39 20 1,000 9,081E-03 0,04650688 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 9,081E-03 0,04640958 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 9,081E-03 0,04631269 ! negative regulation of translation GO:0017148 32 20 1,000 9,081E-03 0,04621621 ! regulation of heart contraction GO:0008016 123 61 2,000 9,876E-03 0,05016159 ! regulation of cell killing GO:0031341 46 21 1,000 9,989E-03 0,05062837 ! lipid phosphorylation GO:0046834 43 21 1,000 9,989E-03 0,05052355 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 1,000 9,989E-03 0,05041916 ! ovarian follicle development GO:0001541 39 21 1,000 9,989E-03 0,0503152 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 9,989E-03 0,05021167 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 9,989E-03 0,05010857 ! actin filament-based movement GO:0030048 47 21 1,000 9,989E-03 0,05000589 ! hindlimb morphogenesis GO:0035137 47 22 1,000 0,01093582 0,05463435 ! cellular response to starvation GO:0009267 37 22 1,000 0,01093582 0,05452285 ! ureteric bud development GO:0001657 50 22 1,000 0,01093582 0,0544118 ! cell aging GO:0007569 48 22 1,000 0,01093582 0,05430121 ! stem cell differentiation GO:0048863 57 22 1,000 0,01093582 0,05419107 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 0,01093582 0,05408137 ! renal system process GO:0003014 42 22 1,000 0,01093582 0,05397211 ! positive regulation of adaptive immune response GO:0002821 42 22 1,000 0,01093582 0,0538633 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 0,01093582 0,05375492 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 0,01093582 0,05364698 ! gut development GO:0048565 44 22 1,000 0,01093582 0,05353947 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 0,01093582 0,05343239 ! protein stabilization GO:0050821 41 22 1,000 0,01093582 0,05332574 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 0,01125421 0,05476898 ! multicellular organism reproduction GO:0032504 123 65 2,000 0,01173688 0,05700436 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 0,0119207 0,0577823 ! gluconeogenesis GO:0006094 38 23 1,000 0,0119207 0,05766788 ! regeneration GO:0031099 42 23 1,000 0,0119207 0,05755391 ! regulation of DNA recombination GO:0000018 51 23 1,000 0,0119207 0,05744039 ! response to ethanol GO:0045471 47 23 1,000 0,0119207 0,05732732 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 0,0119207 0,05721469 ! DNA modification GO:0006304 36 23 1,000 0,0119207 0,05710251 ! embryonic limb morphogenesis GO:0030326 139 67 2,000 0,01273754 0,06089589 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 139 67 2,000 0,01273754 0,06077695 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 0,01294297 0,06163679 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01294297 0,06151687 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 0,01294297 0,06139742 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 0,01294297 0,06127843 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to corticosteroid stimulus GO:0031960 46 24 1,000 0,01294297 0,06115991 ! regulation of viral reproduction GO:0050792 41 24 1,000 0,01294297 0,06104184 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 0,01294297 0,06092422 GO:0002708|positive regulation of lymphocyte mediated immunity, ! oogenesis GO:0048477 44 24 1,000 0,01294297 0,06080706 ! synaptic vesicle transport GO:0048489 52 24 1,000 0,01294297 0,06069035 ! hexose catabolic process GO:0019320 113 68 2,000 0,0132556 0,06203724 ! urogenital system development GO:0001655 149 69 2,000 0,01378555 0,06439407 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 0,01400202 0,06528042 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 0,01400202 0,06515607 ! leukocyte adhesion GO:0007159 55 25 1,000 0,01400202 0,0650322 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 0,01400202 0,0649088 ! negative regulation of DNA replication GO:0008156 45 25 1,000 0,01400202 0,06478587 ! immunoglobulin production GO:0002377 62 25 1,000 0,01400202 0,0646634 GO:0002440|production of molecular mediator of immune response, ! leukocyte homeostasis GO:0001776 50 25 1,000 0,01400202 0,06454139 ! germ cell development GO:0007281 133 70 2,000 0,01432741 0,06591687 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,01509728 0,06932831 ! myelination GO:0042552 50 26 1,000 0,01509728 0,06919824 ! initiation of viral infection GO:0019059 60 26 1,000 0,01509728 0,06906865 ! pyruvate metabolic process GO:0006090 43 26 1,000 0,01509728 0,06893955 ! molting cycle process GO:0022404 52 26 1,000 0,01509728 0,06881093 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein amino acid alkylation GO:0008213 59 26 1,000 0,01509728 0,06868279 GO:0006479|protein amino acid methylation, ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01509728 0,06855513 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 0,01509728 0,06842794 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 0,01509728 0,06830122 ! neural crest cell development GO:0014032 59 26 1,000 0,01509728 0,06817497 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 1,000 0,01509728 0,06804919 GO:0050768|negative regulation of neurogenesis, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 0,01509728 0,06792387 ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01509728 0,06779901 GO:0045840|positive regulation of mitosis, ! appendage morphogenesis GO:0035107 150 72 2,000 0,01544698 0,06924217 GO:0035108|limb morphogenesis, ! actin filament organization GO:0007015 167 72 2,000 0,01544698 0,06911535 ! B cell activation GO:0042113 179 72 2,000 0,01544698 0,068989 ! appendage development GO:0048736 151 73 2,000 0,01602475 0,07143882 GO:0060173|limb development, ! mitochondrial membrane organization GO:0007006 60 27 1,000 0,01622817 0,0722139 ! response to starvation GO:0042594 47 27 1,000 0,01622817 0,0720826 ! response to toxin GO:0009636 49 27 1,000 0,01622817 0,07195178 ! cellular response to nutrient levels GO:0031669 45 27 1,000 0,01622817 0,07182143 ! regulation of caspase activity GO:0043281 136 74 2,000 0,01661455 0,07339844 ! regulation of transcription factor activity GO:0051090 137 75 2,000 0,01721638 0,07591989 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 2,000 0,01721638 0,0757831 ! axon guidance GO:0007411 162 75 2,000 0,01721638 0,0756468 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 0,01739413 0,0762906 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 0,01739413 0,07615388 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01739413 0,07601764 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 0,01739413 0,0758819 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 0,01739413 0,07574664 ! lipid oxidation GO:0034440 48 28 1,000 0,01739413 0,07561186 GO:0019395|fatty acid oxidation, ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 2,000 0,01783028 0,0773701 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 0,01845625 0,07994436 ! cytosolic calcium ion homeostasis GO:0051480 149 77 2,000 0,01845625 0,07980286 ! monosaccharide catabolic process GO:0046365 125 77 2,000 0,01845625 0,07966187 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01859459 0,08011743 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01859459 0,07997638 ! autophagy GO:0006914 47 29 1,000 0,01859459 0,07983583 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 0,01859459 0,07969576 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01859459 0,07955619 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01859459 0,07941711 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01859459 0,07927851 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 0,01909431 0,08126725 ! immune response-activating signal transduction GO:0002757 58 30 1,000 0,019829 0,08424737 GO:0002764|immune response-regulating signal transduction, ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,019829 0,08410111 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 0,019829 0,08395535 GO:0048871|multicellular organismal homeostasis, ! meiosis GO:0007126 143 81 2,000 0,02108114 0,08910246 GO:0051327|M phase of meiotic cell cycle, ! ovulation cycle process GO:0022602 55 31 1,000 0,0210968 0,08901464 ! male gonad development GO:0008584 56 31 1,000 0,0210968 0,08886117 ! ensheathment of neurons GO:0007272 64 31 1,000 0,0210968 0,08870822 GO:0008366|axon ensheathment, ! fatty acid catabolic process GO:0009062 54 31 1,000 0,0210968 0,0885558 ! response to heat GO:0009408 54 31 1,000 0,0210968 0,08840391 ! positive regulation of immune effector process GO:0002699 78 31 1,000 0,0210968 0,08825253 ! regulation of peptidase activity GO:0052547 150 82 2,000 0,02176765 0,09090319 ! meiotic cell cycle GO:0051321 144 82 2,000 0,02176765 0,09074806 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,02239745 0,09321461 ! collagen metabolic process GO:0032963 49 32 1,000 0,02239745 0,09305609 ! spindle organization GO:0007051 50 32 1,000 0,02239745 0,0928981 ! positive regulation of T cell proliferation GO:0042102 60 32 1,000 0,02239745 0,09274064 ! metanephros development GO:0001656 81 32 1,000 0,02239745 0,09258372 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,02239745 0,09242733 ! mesoderm formation GO:0001707 73 32 1,000 0,02239745 0,09227146 ! hexose biosynthetic process GO:0019319 53 32 1,000 0,02239745 0,09211613 ! ovulation cycle GO:0042698 57 32 1,000 0,02239745 0,09196131 ! peripheral nervous system development GO:0007422 68 32 1,000 0,02239745 0,09180701 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,02239745 0,09165323 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,02239745 0,09149996 ! gene silencing GO:0016458 71 32 1,000 0,02239745 0,09134721 ! response to drug GO:0042493 149 83 2,000 0,02246628 0,09147521 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,02373042 0,09646161 ! response to ionizing radiation GO:0010212 74 33 1,000 0,02373042 0,09630137 ! negative regulation of transport GO:0051051 164 85 2,000 0,02389991 0,09682833 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,02389991 0,09666802 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,0246349 0,09947615 GO:0002696|positive regulation of leukocyte activation, ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,02509518 0,10116753 ! post-embryonic development GO:0009791 76 34 1,000 0,02509518 0,10100086 ! formation of primary germ layer GO:0001704 76 34 1,000 0,02509518 0,10083474 ! cell fate specification GO:0001708 56 34 1,000 0,02509518 0,10066917 ! adult locomotory behavior GO:0008344 62 34 1,000 0,02509518 0,10050414 ! alcohol catabolic process GO:0046164 142 87 2,000 0,025382 0,10148648 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,02649119 0,10574835 ! regulation of synaptic plasticity GO:0048167 78 35 1,000 0,02649119 0,10557584 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 0,02649119 0,10540389 ! mesoderm morphogenesis GO:0048332 80 35 1,000 0,02649119 0,1052325 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,02649119 0,10506167 ! regulation of DNA binding GO:0051101 167 89 2,000 0,0269125 0,10655954 ! tube morphogenesis GO:0035239 194 89 2,000 0,0269125 0,10638711 ! regulation of neurological system process GO:0031644 175 89 2,000 0,0269125 0,10621524 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,02791795 0,11000572 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,02791795 0,10982858 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,02791795 0,109652 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02791795 0,109476 ! embryonic organ development GO:0048568 67 36 1,000 0,02791795 0,10930055 ! monosaccharide biosynthetic process GO:0046364 57 36 1,000 0,02791795 0,10912567 ! sister chromatid segregation GO:0000819 65 37 1,000 0,02937493 0,11463729 ! female gonad development GO:0008585 71 37 1,000 0,02937493 0,11445446 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,03086162 0,12005564 ! meiosis I GO:0007127 74 38 1,000 0,03086162 0,11986478 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,03086162 0,11967451 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,03086162 0,11948486 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,03086162 0,1192958 ! glycogen metabolic process GO:0005977 63 38 1,000 0,03086162 0,11910734 ! pigment metabolic process GO:0042440 87 38 1,000 0,03086162 0,11891947 ! female pregnancy GO:0007565 166 94 2,000 0,03094982 0,11907153 ! regulation of membrane potential GO:0042391 179 94 2,000 0,03094982 0,11888431 ! regulation of defense response GO:0031347 171 95 2,000 0,03179334 0,12193269 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,03179334 0,12174157 ! carbohydrate homeostasis GO:0033500 59 39 1,000 0,03237753 0,12378453 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,03237753 0,12359112 ! glucan metabolic process GO:0044042 64 39 1,000 0,03237753 0,12339831 GO:0006073|cellular glucan metabolic process, ! sex differentiation GO:0007548 171 96 2,000 0,03264882 0,1242384 ! regulation of protein localization GO:0032880 188 97 2,000 0,03351624 0,12734085 ! learning GO:0007612 82 40 1,000 0,03392216 0,12868299 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,03392216 0,12848348 GO:0046660|female sex differentiation, ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,03392216 0,12828459 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,03549502 0,13402525 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03563532 0,13434735 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03563532 0,13414035 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03563532 0,13393398 ! neuron fate determination GO:0048664 7 5 0,000 0,03563532 0,13372824 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03563532 0,13352314 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03563532 0,13331866 ! polyol transport GO:0015791 12 5 0,000 0,03563532 0,13311481 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03563532 0,13291158 ! response to superoxide GO:0000303 10 5 0,000 0,03563532 0,13270897 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03563532 0,13250698 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,03563532 0,1323056 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03563532 0,13210483 ! female meiosis GO:0007143 10 5 0,000 0,03563532 0,13190467 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,03563532 0,13170512 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03563532 0,13150617 ! hypothalamus development GO:0021854 9 5 0,000 0,03563532 0,13130782 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03563532 0,13111007 ! cobalt ion transport GO:0006824 11 5 0,000 0,03563532 0,13091291 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03563532 0,13071634 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03563532 0,13052037 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03563532 0,13032498 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03563532 0,13013017 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03563532 0,12993595 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03563532 0,1297423 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03563532 0,12954923 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03563532 0,12935674 ! transposition GO:0032196 9 5 0,000 0,03563532 0,12916482 ! negative chemotaxis GO:0050919 16 5 0,000 0,03563532 0,12897346 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03563532 0,12878267 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03563532 0,12859245 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03563532 0,12840278 ! behavioral response to pain GO:0048266 10 5 0,000 0,03563532 0,12821368 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03563532 0,12802513 ! Notch receptor processing GO:0007220 11 5 0,000 0,03563532 0,12783713 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03563532 0,12764969 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03563532 0,12746279 ! micturition GO:0060073 9 5 0,000 0,03563532 0,12727644 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03563532 0,12709064 ! copulation GO:0007620 9 5 0,000 0,03563532 0,12690537 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03563532 0,12672065 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03563532 0,12653646 ! bioluminescence GO:0008218 9 5 0,000 0,03563532 0,12635281 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03563532 0,12616969 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03563532 0,1259871 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03563532 0,12580504 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03563532 0,1256235 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03563532 0,12544249 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03563532 0,12526199 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03563532 0,12508202 ! grooming behavior GO:0007625 6 5 0,000 0,03563532 0,12490256 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03563532 0,12472362 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03563532 0,12454519 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03563532 0,12436726 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03563532 0,12418985 ! response to protozoan GO:0001562 13 5 0,000 0,03563532 0,12401294 ! lymph vessel development GO:0001945 10 5 0,000 0,03563532 0,12383654 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03563532 0,12366063 ! endochondral ossification GO:0001958 17 5 0,000 0,03563532 0,12348523 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03563532 0,12331032 ! single strand break repair GO:0000012 8 5 0,000 0,03563532 0,12313591 ! parathyroid gland development GO:0060017 14 5 0,000 0,03563532 0,12296199 ! anagen GO:0042640 7 5 0,000 0,03563532 0,12278855 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03563532 0,12261561 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03563532 0,12244316 ! cytokine secretion GO:0050663 15 5 0,000 0,03563532 0,12227119 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03563532 0,1220997 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03563532 0,12192869 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03563532 0,12175816 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03563532 0,12158811 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03563532 0,12141853 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03563532 0,12124942 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,03563532 0,12108079 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03563532 0,12091262 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03563532 0,12074492 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03563532 0,12057768 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03563532 0,12041091 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03563532 0,12024459 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03563532 0,12007874 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03563532 0,11991334 ! microvillus organization GO:0032528 8 5 0,000 0,03563532 0,1197484 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03563532 0,11958391 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03563532 0,11941987 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03563532 0,11925628 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03563532 0,11909314 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03563532 0,11893044 ! polyol catabolic process GO:0046174 9 5 0,000 0,03563532 0,11876819 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03563532 0,11860638 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03563532 0,11844501 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03563532 0,11828408 ! muscle cell migration GO:0014812 8 5 0,000 0,03563532 0,11812359 ! mitochondrial fission GO:0000266 8 5 0,000 0,03563532 0,11796353 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03563532 0,1178039 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03563532 0,11764471 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,03563532 0,11748595 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03563532 0,11732761 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03563532 0,1171697 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03563532 0,11701221 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03563532 0,11685515 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03563532 0,11669851 ! response to food GO:0032094 6 5 0,000 0,03563532 0,11654228 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03563532 0,11638648 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03563532 0,11623109 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03563532 0,11607611 ! forebrain neuron development GO:0021884 13 5 0,000 0,03563532 0,11592155 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03563532 0,1157674 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,03563532 0,11561366 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03563532 0,11546033 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03563532 0,1153074 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03563532 0,11515487 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03563532 0,11500275 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03563532 0,11485104 ! lipid glycosylation GO:0030259 7 5 0,000 0,03563532 0,11469972 ! nucleobase transport GO:0015851 6 5 0,000 0,03563532 0,1145488 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03563532 0,11439827 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03563532 0,11424814 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,03563532 0,11409841 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03563532 0,11394906 ! basic amino acid transport GO:0015802 12 5 0,000 0,03563532 0,11380011 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,03563532 0,11365155 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03563532 0,11350337 ! actin nucleation GO:0045010 11 5 0,000 0,03563532 0,11335558 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03563532 0,11320817 ! depurination GO:0045007 5 5 0,000 0,03563532 0,11306115 ! depyrimidination GO:0045008 10 5 0,000 0,03563532 0,11291451 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03563532 0,11276825 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03563532 0,11262236 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,03563532 0,11247685 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03563532 0,11233172 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03563532 0,11218697 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03563532 0,11204258 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03563532 0,11189857 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03563532 0,11175492 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03563532 0,11161165 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03563532 0,11146874 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03563532 0,1113262 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03563532 0,11118402 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03563532 0,1110422 ! response to arsenic GO:0046685 11 5 0,000 0,03563532 0,11090075 ! mast cell degranulation GO:0043303 7 5 0,000 0,03563532 0,11075965 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03563532 0,11061891 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03563532 0,11047853 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03563532 0,11033851 ! response to mercury ion GO:0046689 8 5 0,000 0,03563532 0,11019884 ! response to cadmium ion GO:0046686 7 5 0,000 0,03563532 0,11005953 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03563532 0,10992056 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03563532 0,10978195 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03563532 0,10964368 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03563532 0,10950577 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03563532 0,1093682 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03563532 0,10923097 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03563532 0,10909409 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03563532 0,10895755 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03563532 0,10882136 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03563532 0,1086855 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03563532 0,10854998 ! embryonic cleavage GO:0040016 6 5 0,000 0,03563532 0,1084148 ! peroxisome fission GO:0016559 5 5 0,000 0,03563532 0,10827996 ! histone demethylation GO:0016577 13 5 0,000 0,03563532 0,10814545 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03563532 0,10801127 ! mitotic recombination GO:0006312 9 5 0,000 0,03563532 0,10787743 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03563532 0,10774392 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03563532 0,10761074 ! metaphase plate congression GO:0051310 7 5 0,000 0,03563532 0,10747788 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03563532 0,10734536 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03563532 0,10721316 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03563532 0,10708129 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03563532 0,10694974 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03563532 0,10681851 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03563532 0,1066876 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03563532 0,10655702 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03563532 0,10642675 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03563532 0,10629681 ! metaphase GO:0051323 11 5 0,000 0,03563532 0,10616718 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03563532 0,10603786 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03563532 0,10590886 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03563532 0,10578018 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03563532 0,1056518 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03563532 0,10552374 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03563532 0,10539599 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03563532 0,10526854 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03563532 0,10514141 ! response to redox state GO:0051775 6 5 0,000 0,03563532 0,10501458 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03563532 0,10488805 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03563532 0,10476184 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03563532 0,10463592 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03563532 0,10451031 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03563532 0,10438499 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03563532 0,10425998 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03563532 0,10413527 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03563532 0,10401085 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03563532 0,10388674 ! striatum development GO:0021756 14 5 0,000 0,03563532 0,10376291 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03563532 0,10363939 ! glial cell migration GO:0008347 10 5 0,000 0,03563532 0,10351615 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03563532 0,10339321 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03563532 0,10327056 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03563532 0,10314821 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03563532 0,10302614 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03563532 0,10290436 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03563532 0,10278286 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03563532 0,10266166 ! neuroprotection GO:0043526 8 5 0,000 0,03563532 0,10254074 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03563532 0,1024201 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03563532 0,10229975 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03563532 0,10217968 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03563532 0,10205989 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03563532 0,10194038 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03563532 0,10182115 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03563532 0,1017022 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03563532 0,10158353 ! spindle assembly GO:0051225 6 5 0,000 0,03563532 0,10146513 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03563532 0,10134701 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03563532 0,10122917 ! protein palmitoylation GO:0018345 12 5 0,000 0,03563532 0,1011116 ! drug metabolic process GO:0017144 7 5 0,000 0,03563532 0,1009943 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03563532 0,10087727 ! organ regeneration GO:0031100 7 5 0,000 0,03563532 0,10076052 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03563532 0,10064403 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03563532 0,10052781 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,03618987 0,10197446 GO:0060538|skeletal muscle organ development, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,03709562 0,10440622 ! ear morphogenesis GO:0042471 64 42 1,000 0,03709562 0,10428608 ! alcohol biosynthetic process GO:0046165 65 42 1,000 0,03709562 0,10416621 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,03709562 0,10404661 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,03709562 0,1039273 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,03709562 0,10380825 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,03872348 0,10823966 GO:0090047|positive regulation of transcription regulator activity, ! glucose transport GO:0015758 66 43 1,000 0,03872348 0,10811596 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 1,000 0,03872348 0,10799254 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,03872348 0,1078694 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,03872348 0,10774655 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,04037813 0,11222272 ! hexose transport GO:0008645 68 44 1,000 0,04037813 0,1120952 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 0,04037813 0,11196796 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 1,000 0,0420591 0,11649703 ! female gamete generation GO:0007292 71 45 1,000 0,0420591 0,11636509 ! developmental growth GO:0048589 88 45 1,000 0,0420591 0,11623346 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04260912 0,11762042 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04260912 0,11748766 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,04260912 0,11735521 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,04260912 0,11722305 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04260912 0,11709119 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,04260912 0,11695963 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,04260912 0,11682836 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04260912 0,11669739 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,04260912 0,11656671 ! response to oxygen radical GO:0000305 11 6 0,000 0,04260912 0,11643632 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,04260912 0,11630622 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,04260912 0,11617642 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,04260912 0,1160469 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,04260912 0,11591767 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04260912 0,11578873 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,04260912 0,11566008 ! forebrain regionalization GO:0021871 9 6 0,000 0,04260912 0,11553171 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04260912 0,11540362 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,04260912 0,11527582 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04260912 0,11514831 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,04260912 0,11502107 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,04260912 0,11489412 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04260912 0,11476744 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,04260912 0,11464104 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04260912 0,11451493 ! malate metabolic process GO:0006108 13 6 0,000 0,04260912 0,11438909 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,04260912 0,11426352 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,04260912 0,11413823 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,04260912 0,11401322 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,04260912 0,11388848 ! protein refolding GO:0042026 15 6 0,000 0,04260912 0,11376401 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04260912 0,11363981 ! opsonization GO:0008228 8 6 0,000 0,04260912 0,11351589 ! mating behavior GO:0007617 7 6 0,000 0,04260912 0,11339223 ! erythrocyte maturation GO:0043249 8 6 0,000 0,04260912 0,11326884 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,04260912 0,11314573 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,04260912 0,11302288 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,04260912 0,11290029 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04260912 0,11277797 ! response to interferon-gamma GO:0034341 16 6 0,000 0,04260912 0,11265592 ! toxin metabolic process GO:0009404 11 6 0,000 0,04260912 0,11253413 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04260912 0,1124126 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,04260912 0,11229134 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,04260912 0,11217033 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,04260912 0,11204959 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,04260912 0,11192911 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,04260912 0,11180888 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04260912 0,11168891 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,04260912 0,1115692 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,04260912 0,11144975 ! protein lipoylation GO:0009249 10 6 0,000 0,04260912 0,11133055 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,04260912 0,11121161 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,04260912 0,11109292 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04260912 0,11097449 ! glutamate catabolic process GO:0006538 12 6 0,000 0,04260912 0,1108563 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,04260912 0,11073837 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04260912 0,11062069 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,04260912 0,11050326 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04260912 0,11038607 ! hyperosmotic response GO:0006972 10 6 0,000 0,04260912 0,11026914 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,04260912 0,11015245 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,04260912 0,11003601 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,04260912 0,10991982 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,04260912 0,10980387 ! urea metabolic process GO:0019627 7 6 0,000 0,04260912 0,10968816 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04260912 0,1095727 ! neutrophil activation GO:0042119 7 6 0,000 0,04260912 0,10945748 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04260912 0,10934251 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,04260912 0,10922777 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04260912 0,10911328 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,04260912 0,10899902 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04260912 0,10888501 ! neuron apoptosis GO:0051402 15 6 0,000 0,04260912 0,10877123 ! T cell mediated immunity GO:0002456 17 6 0,000 0,04260912 0,10865769 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04260912 0,10854439 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,04260912 0,10843132 ! carnitine transport GO:0015879 10 6 0,000 0,04260912 0,10831849 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04260912 0,10820589 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,04260912 0,10809353 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,04260912 0,1079814 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,04260912 0,1078695 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,04260912 0,10775783 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04260912 0,1076464 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,04260912 0,10753519 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,04260912 0,10742422 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,04260912 0,10731347 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,04260912 0,10720295 ! response to UV-C GO:0010225 14 6 0,000 0,04260912 0,10709266 ! astrocyte development GO:0014002 16 6 0,000 0,04260912 0,1069826 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,04260912 0,10687276 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04260912 0,10676315 ! interaction with symbiont GO:0051702 14 6 0,000 0,04260912 0,10665376 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04260912 0,10654459 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,04260912 0,10643565 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,04260912 0,10632693 ! response to copper ion GO:0046688 10 6 0,000 0,04260912 0,10621844 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,04260912 0,10611016 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,04260912 0,10600211 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04260912 0,10589427 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,04260912 0,10578665 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,04260912 0,10567926 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04260912 0,10557208 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,04260912 0,10546511 ! hair follicle maturation GO:0048820 8 6 0,000 0,04260912 0,10535837 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04260912 0,10525184 ! Schwann cell development GO:0014044 15 6 0,000 0,04260912 0,10514552 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,04260912 0,10503942 ! response to pheromone GO:0019236 6 6 0,000 0,04260912 0,10493354 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,04260912 0,10482786 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,04260912 0,1047224 ! subpallium development GO:0021544 15 6 0,000 0,04260912 0,10461715 ! neural tube patterning GO:0021532 8 6 0,000 0,04260912 0,10451212 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,04260912 0,10440729 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,04260912 0,10430267 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04260912 0,10419827 ! G2 phase GO:0051319 16 6 0,000 0,04260912 0,10409407 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,04260912 0,10399008 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,04260912 0,1038863 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04260912 0,10378272 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,04260912 0,10367935 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04260912 0,10357619 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,04260912 0,10347323 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04260912 0,10337047 ! receptor internalization GO:0031623 11 6 0,000 0,04260912 0,10326792 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,04260912 0,10316558 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,04260912 0,10306343 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,04260912 0,10296149 ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,04260912 0,10285975 ! protein deubiquitination GO:0016579 16 6 0,000 0,04260912 0,10275821 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,04260912 0,10265687 ! protein destabilization GO:0031648 9 6 0,000 0,04260912 0,10255573 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,04260912 0,10245479 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04260912 0,10235405 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,04260912 0,10225351 ! regulation of viral transcription GO:0046782 11 6 0,000 0,04260912 0,10215316 ! progesterone metabolic process GO:0042448 12 6 0,000 0,04260912 0,10205301 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,04260912 0,10195305 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,04260912 0,1018533 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,04260912 0,10175373 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04260912 0,10165436 ! determination of adult lifespan GO:0008340 17 6 0,000 0,04260912 0,10155519 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,04260912 0,10145621 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04260912 0,10135742 ! neural plate development GO:0001840 9 6 0,000 0,04260912 0,10125882 ! catecholamine transport GO:0051937 9 6 0,000 0,04260912 0,10116042 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,04260912 0,1010622 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04260912 0,10096418 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,04260912 0,10086635 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,04260912 0,1007687 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,04260912 0,10067125 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04260912 0,10057398 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,04260912 0,1004769 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,04260912 0,10038001 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,04260912 0,1002833 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,04260912 0,10018678 GO:0055081|anion homeostasis, ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,04376592 0,10280783 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,04376592 0,10270907 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 1,000 0,04376592 0,1026105 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,04376592 0,10251212 ! mitochondrial transport GO:0006839 94 48 1,000 0,0472553 0,11057921 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,0472553 0,11047339 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,0472553 0,11036777 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,0472553 0,11026236 ! male sex differentiation GO:0046661 93 48 1,000 0,0472553 0,11015715 ! regulation of adaptive immune response GO:0002819 92 48 1,000 0,0472553 0,11005214 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,04903695 0,11409264 ! tRNA transcription GO:0009304 17 7 0,000 0,04953267 0,11513637 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04953267 0,11502692 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04953267 0,11491769 ! regulation of helicase activity GO:0051095 16 7 0,000 0,04953267 0,11480866 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04953267 0,11469983 ! sleep GO:0030431 16 7 0,000 0,04953267 0,11459122 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04953267 0,1144828 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04953267 0,1143746 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04953267 0,11426659 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04953267 0,1141588 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04953267 0,1140512 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04953267 0,11394381 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04953267 0,11383662 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04953267 0,11372963 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04953267 0,11362284 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04953267 0,11351625 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04953267 0,11340986 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04953267 0,11330367 ! glycolipid transport GO:0046836 11 7 0,000 0,04953267 0,11319768 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04953267 0,11309189 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04953267 0,1129863 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04953267 0,1128809 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04953267 0,1127757 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04953267 0,11267069 ! pericardium development GO:0060039 16 7 0,000 0,04953267 0,11256588 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04953267 0,11246127 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04953267 0,11235685 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04953267 0,11225262 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04953267 0,11214859 ! lipoprotein transport GO:0042953 14 7 0,000 0,04953267 0,11204474 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04953267 0,1119411 ! rhythmic behavior GO:0007622 17 7 0,000 0,04953267 0,11183764 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04953267 0,11173437 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04953267 0,1116313 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04953267 0,11152841 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04953267 0,11142571 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04953267 0,11132321 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04953267 0,11122089 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04953267 0,11111875 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04953267 0,11101681 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04953267 0,11091505 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04953267 0,11081348 ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04953267 0,1107121 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04953267 0,1106109 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04953267 0,11050988 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04953267 0,11040905 ! spinal cord patterning GO:0021511 14 7 0,000 0,04953267 0,11030841 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04953267 0,11020795 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04953267 0,11010767 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04953267 0,11000757 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04953267 0,10990765 ! adrenal gland development GO:0030325 17 7 0,000 0,04953267 0,10980792 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04953267 0,10970836 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04953267 0,10960899 ! ovulation GO:0030728 10 7 0,000 0,04953267 0,1095098 ! adenohypophysis development GO:0021984 11 7 0,000 0,04953267 0,10941078 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04953267 0,10931195 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04953267 0,10921329 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04953267 0,10911481 ! microtubule nucleation GO:0007020 21 7 0,000 0,04953267 0,10901651 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04953267 0,10891838 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04953267 0,10882044 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04953267 0,10872266 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04953267 0,10862507 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04953267 0,10852764 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04953267 0,1084304 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04953267 0,10833333 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04953267 0,10823643 ! galactose metabolic process GO:0006012 13 7 0,000 0,04953267 0,1081397 ! vesicle fusion GO:0006906 20 7 0,000 0,04953267 0,10804315 ! response to dietary excess GO:0002021 8 7 0,000 0,04953267 0,10794677 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04953267 0,10785056 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04953267 0,10775452 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04953267 0,10765865 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,04953267 0,10756295 ! nucleoside transport GO:0015858 11 7 0,000 0,04953267 0,10746743 ! nucleoside salvage GO:0043174 11 7 0,000 0,04953267 0,10737207 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04953267 0,10727688 ! male sex determination GO:0030238 15 7 0,000 0,04953267 0,10718186 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04953267 0,10708701 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04953267 0,10699233 ! parturition GO:0007567 16 7 0,000 0,04953267 0,10689781 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04953267 0,10680346 ! rRNA modification GO:0000154 14 7 0,000 0,04953267 0,10670928 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04953267 0,10661526 ! spindle checkpoint GO:0031577 16 7 0,000 0,04953267 0,10652141 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04953267 0,10642773 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04953267 0,1063342 ! monocyte differentiation GO:0030224 16 7 0,000 0,04953267 0,10624085 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04953267 0,10614765 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04953267 0,10605462 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04953267 0,10596175 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04953267 0,10586905 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,04953267 0,10577651 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04953267 0,10568413 ! fibrinolysis GO:0042730 11 7 0,000 0,04953267 0,10559191 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04953267 0,10549985 ! eating behavior GO:0042755 8 7 0,000 0,04953267 0,10540795 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04953267 0,10531621 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04953267 0,10522463 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04953267 0,10513321 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04953267 0,10504195 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04953267 0,10495084 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04953267 0,1048599 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04953267 0,10476911 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04953267 0,10467848 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04953267 0,10458801 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04953267 0,10449769 ! histone ubiquitination GO:0016574 9 7 0,000 0,04953267 0,10440753 ! regulation of meiosis GO:0040020 12 7 0,000 0,04953267 0,10431752 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04953267 0,10422767 ! regulation of lipid transport GO:0032368 14 7 0,000 0,04953267 0,10413797 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04953267 0,10404843 ! transcription termination GO:0006353 14 7 0,000 0,04953267 0,10395904 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04953267 0,10386981 ! anaphase GO:0051322 18 7 0,000 0,04953267 0,10378072 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04953267 0,10369179 ! axonal fasciculation GO:0007413 19 7 0,000 0,04953267 0,10360302 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04953267 0,10351439 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04953267 0,10342592 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04953267 0,1033376 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04953267 0,10324942 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04953267 0,1031614 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04953267 0,10307353 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04953267 0,10298581 ! antibiotic transport GO:0042891 9 7 0,000 0,04953267 0,10289823 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04953267 0,10281081 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04953267 0,10272353 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04953267 0,10263641 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04953267 0,10254943 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04953267 0,10246259 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04953267 0,10237591 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04953267 0,10228937 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04953267 0,10220298 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04953267 0,10211673 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04953267 0,10203063 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04953267 0,10194467 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04953267 0,10185886 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04953267 0,10177319 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04953267 0,10168767 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04953267 0,10160229 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04953267 0,10151705 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04953267 0,10143196 ! muscle adaptation GO:0043500 13 7 0,000 0,04953267 0,10134701 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04953267 0,1012622 ! retina homeostasis GO:0001895 12 7 0,000 0,04953267 0,10117753 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04953267 0,101093 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04953267 0,10100862 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04953267 0,10092437 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04953267 0,10084027 ! regulation of action potential GO:0001508 102 50 1,000 0,05084266 0,10342099 ! regulation of ossification GO:0030278 123 50 1,000 0,05084266 0,10333495 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,05084266 0,10324906 ! viral infectious cycle GO:0019058 104 51 1,000 0,05267198 0,10687512 ! response to temperature stimulus GO:0009266 84 51 1,000 0,05267198 0,10678642 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,05267198 0,10669788 ! positive regulation of binding GO:0051099 88 52 1,000 0,05452448 0,11035899 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,05452448 0,11026763 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,05639973 0,11396571 ! synapse organization GO:0050808 102 53 1,000 0,05639973 0,11387152 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,05640636 0,11379086 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,05640636 0,11369697 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,05640636 0,11360324 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,05640636 0,11350967 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05640636 0,11341624 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05640636 0,11332297 ! male meiosis GO:0007140 9 8 0,000 0,05640636 0,11322986 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,05640636 0,11313689 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,05640636 0,11304408 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,05640636 0,11295142 ! meiotic prophase I GO:0007128 14 8 0,000 0,05640636 0,11285891 ! response to zinc ion GO:0010043 12 8 0,000 0,05640636 0,11276656 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,05640636 0,11267435 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05640636 0,1125823 ! oligopeptide transport GO:0006857 16 8 0,000 0,05640636 0,11249039 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,05640636 0,11239864 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,05640636 0,11230704 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,05640636 0,11221558 ! signal peptide processing GO:0006465 12 8 0,000 0,05640636 0,11212427 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,05640636 0,11203312 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,05640636 0,11194211 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05640636 0,11185124 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,05640636 0,11176053 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,05640636 0,11166996 ! estrogen metabolic process GO:0008210 17 8 0,000 0,05640636 0,11157954 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,05640636 0,11148927 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,05640636 0,11139914 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05640636 0,11130915 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05640636 0,11121932 ! reflex GO:0060004 17 8 0,000 0,05640636 0,11112962 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05640636 0,11104008 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,05640636 0,11095067 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05640636 0,11086141 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,05640636 0,11077229 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,05640636 0,11068332 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,05640636 0,11059449 ! astrocyte differentiation GO:0048708 19 8 0,000 0,05640636 0,1105058 ! histidine catabolic process GO:0006548 10 8 0,000 0,05640636 0,11041725 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05640636 0,11032885 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,05640636 0,11024059 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,05640636 0,11015246 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,05640636 0,11006448 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,05640636 0,10997664 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,05640636 0,10988894 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,05640636 0,10980138 ! macrophage activation GO:0042116 13 8 0,000 0,05640636 0,10971396 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05640636 0,10962668 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,05640636 0,10953953 ! purine salvage GO:0043101 12 8 0,000 0,05640636 0,10945253 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,05640636 0,10936566 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,05640636 0,10927893 ! osteoblast development GO:0002076 17 8 0,000 0,05640636 0,10919234 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,05640636 0,10910589 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,05640636 0,10901957 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,05640636 0,10893339 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,05640636 0,10884734 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05640636 0,10876143 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,05640636 0,10867566 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05640636 0,10859002 ! intermediate filament organization GO:0045109 12 8 0,000 0,05640636 0,10850451 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,05640636 0,10841915 ! cellular extravasation GO:0045123 13 8 0,000 0,05640636 0,10833391 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,05640636 0,10824881 ! response to antibiotic GO:0046677 11 8 0,000 0,05640636 0,10816384 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,05640636 0,10807901 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,05640636 0,10799431 ! DNA topological change GO:0006265 12 8 0,000 0,05640636 0,10790974 ! response to tropane GO:0014073 15 8 0,000 0,05640636 0,1078253 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05640636 0,107741 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05640636 0,10765682 ! mast cell activation GO:0045576 14 8 0,000 0,05640636 0,10757278 ! multicellular organismal aging GO:0010259 20 8 0,000 0,05640636 0,10748887 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,05640636 0,10740509 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,05640636 0,10732144 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05640636 0,10723793 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05640636 0,10715454 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,05640636 0,10707128 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05640636 0,10698815 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,05640636 0,10690515 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,05640636 0,10682227 ! intracellular lipid transport GO:0032365 16 8 0,000 0,05640636 0,10673953 ! response to tumor cell GO:0002347 16 8 0,000 0,05640636 0,10665691 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05640636 0,10657443 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,05640636 0,10649207 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,05640636 0,10640983 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05640636 0,10632773 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,05640636 0,10624575 ! hormone catabolic process GO:0042447 17 8 0,000 0,05640636 0,10616389 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,05640636 0,10608217 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,05640636 0,10600056 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,05640636 0,10591909 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,05640636 0,10583774 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05640636 0,10575651 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,05640636 0,10567541 ! adult feeding behavior GO:0008343 10 8 0,000 0,05640636 0,10559443 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,05640636 0,10551358 ! ATP catabolic process GO:0006200 11 8 0,000 0,05640636 0,10543285 ! blastocyst growth GO:0001832 19 8 0,000 0,05640636 0,10535224 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05640636 0,10527176 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,05640636 0,1051914 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05640636 0,10511116 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,05640636 0,10503105 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,05640636 0,10495105 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,05640636 0,10487118 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,05640636 0,10479143 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,05640636 0,1047118 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05640636 0,1046323 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,05640636 0,10455291 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05640636 0,10447364 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,05640636 0,1043945 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,05640636 0,10431547 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,05640636 0,10423656 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,05640636 0,10415777 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,05640636 0,1040791 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,05829732 0,10748705 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 1,000 0,05829732 0,10740599 ! embryonic skeletal system development GO:0048706 101 54 1,000 0,05829732 0,10732505 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,05829732 0,10724423 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,06021681 0,110692 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,0621578 0,11417407 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,06323052 0,11605723 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,06323052 0,1159701 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06323052 0,1158831 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,06323052 0,11579623 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,06323052 0,11570949 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,06323052 0,11562288 ! reproductive behavior GO:0019098 22 9 0,000 0,06323052 0,1155364 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06323052 0,11545005 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,06323052 0,11536383 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,06323052 0,11527774 ! UTP metabolic process GO:0046051 10 9 0,000 0,06323052 0,11519178 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,06323052 0,11510594 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,06323052 0,11502023 ! artery development GO:0060840 25 9 0,000 0,06323052 0,11493465 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,06323052 0,1148492 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,06323052 0,11476387 ! equilibrioception GO:0050957 20 9 0,000 0,06323052 0,11467867 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,06323052 0,1145936 ! chemosensory behavior GO:0007635 21 9 0,000 0,06323052 0,11450865 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,06323052 0,11442383 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06323052 0,11433914 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,06323052 0,11425456 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,06323052 0,11417012 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,06323052 0,1140858 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,06323052 0,1140016 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06323052 0,11391753 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06323052 0,11383358 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,06323052 0,11374976 ! protein targeting to ER GO:0045047 25 9 0,000 0,06323052 0,11366606 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,06323052 0,11358248 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,06323052 0,11349902 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,06323052 0,11341569 ! glycine catabolic process GO:0006546 15 9 0,000 0,06323052 0,11333248 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,06323052 0,11324939 ! endosome organization GO:0007032 20 9 0,000 0,06323052 0,11316643 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06323052 0,11308358 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,06323052 0,11300086 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06323052 0,11291825 ! mannose metabolic process GO:0006013 13 9 0,000 0,06323052 0,11283577 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,06323052 0,11275341 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,06323052 0,11267117 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,06323052 0,11258905 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,06323052 0,11250704 ! receptor clustering GO:0043113 20 9 0,000 0,06323052 0,11242516 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,06323052 0,1123434 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06323052 0,11226175 ! retinol metabolic process GO:0042572 20 9 0,000 0,06323052 0,11218023 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,06323052 0,11209882 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,06323052 0,11201753 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,06323052 0,11193636 ! macrophage differentiation GO:0030225 15 9 0,000 0,06323052 0,1118553 ! oligodendrocyte development GO:0014003 11 9 0,000 0,06323052 0,11177436 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,06323052 0,11169354 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06323052 0,11161284 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,06323052 0,11153225 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06323052 0,11145178 ! response to amine stimulus GO:0014075 13 9 0,000 0,06323052 0,11137143 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06323052 0,11129119 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,06323052 0,11121107 ! erythrocyte development GO:0048821 17 9 0,000 0,06323052 0,11113106 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06323052 0,11105117 ! renal water homeostasis GO:0003091 15 9 0,000 0,06323052 0,11097139 ! postreplication repair GO:0006301 25 9 0,000 0,06323052 0,11089172 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,06323052 0,11081217 ! icosanoid secretion GO:0032309 15 9 0,000 0,06323052 0,11073274 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06323052 0,11065342 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,06323052 0,11057421 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,06323052 0,11049512 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,06323052 0,11041613 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06323052 0,11033727 ! sterol catabolic process GO:0016127 14 9 0,000 0,06323052 0,11025851 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06323052 0,11017987 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,06323052 0,11010133 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,06323052 0,11002291 ! S phase GO:0051320 10 9 0,000 0,06323052 0,10994461 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,06323052 0,10986641 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,06323052 0,10978832 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,06323052 0,10971035 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,06323052 0,10963249 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,06323052 0,10955473 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06323052 0,10947709 ! purine base metabolic process GO:0006144 25 9 0,000 0,06323052 0,10939955 ! pigment granule transport GO:0051904 17 9 0,000 0,06323052 0,10932213 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,06323052 0,10924482 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,06323052 0,10916761 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06323052 0,10909052 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,06323052 0,10901353 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,06323052 0,10893665 ! mitochondrion localization GO:0051646 18 9 0,000 0,06323052 0,10885988 ! chloride transport GO:0006821 102 57 1,000 0,06411989 0,1103133 ! muscle fiber development GO:0048747 131 57 1,000 0,06411989 0,11023567 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,06411989 0,11015815 ! heart morphogenesis GO:0003007 105 57 1,000 0,06411989 0,11008074 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,06411989 0,11000343 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,06610266 0,11332547 ! gastrulation GO:0007369 122 58 1,000 0,06610266 0,113246 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,06610266 0,11316664 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,06610266 0,11308739 ! establishment of organelle localization GO:0051656 122 59 1,000 0,06810572 0,11643266 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,07000553 0,11959686 ! regulation of developmental growth GO:0048638 16 10 0,000 0,07000553 0,11951328 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,07000553 0,11942982 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,07000553 0,11934648 ! associative learning GO:0008306 21 10 0,000 0,07000553 0,11926325 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,07000553 0,11918014 ! phosphate transport GO:0006817 24 10 0,000 0,07000553 0,11909715 ! cell volume homeostasis GO:0006884 17 10 0,000 0,07000553 0,11901427 ! CTP metabolic process GO:0046036 11 10 0,000 0,07000553 0,11893151 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,07000553 0,11884886 ! GTP metabolic process GO:0046039 11 10 0,000 0,07000553 0,11876632 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,07000553 0,1186839 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,07000553 0,1186016 ! social behavior GO:0035176 29 10 0,000 0,07000553 0,11851941 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,07000553 0,11843733 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,07000553 0,11835537 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,07000553 0,11827352 ! androgen metabolic process GO:0008209 17 10 0,000 0,07000553 0,11819178 ! phospholipid efflux GO:0033700 19 10 0,000 0,07000553 0,11811016 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,07000553 0,11802864 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,07000553 0,11794725 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,07000553 0,11786596 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,07000553 0,11778478 ! pathogenesis GO:0009405 17 10 0,000 0,07000553 0,11770372 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07000553 0,11762277 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,07000553 0,11754193 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,07000553 0,1174612 ! endoderm development GO:0007492 18 10 0,000 0,07000553 0,11738058 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,07000553 0,11730007 ! arginine catabolic process GO:0006527 17 10 0,000 0,07000553 0,11721967 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,07000553 0,11713939 ! proline metabolic process GO:0006560 13 10 0,000 0,07000553 0,11705921 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,07000553 0,11697914 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,07000553 0,11689918 ! V(D)J recombination GO:0033151 34 10 0,000 0,07000553 0,11681933 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,07000553 0,11673959 ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,07000553 0,11665996 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,07000553 0,11658044 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,07000553 0,11650103 ! multicellular organism growth GO:0035264 19 10 0,000 0,07000553 0,11642172 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,07000553 0,11634252 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,07000553 0,11626343 ! ruffle organization GO:0031529 17 10 0,000 0,07000553 0,11618445 ! epithelial cell development GO:0002064 21 10 0,000 0,07000553 0,11610557 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,07000553 0,1160268 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,07000553 0,11594814 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,07000553 0,11586958 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,07000553 0,11579113 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,07000553 0,11571279 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,07000553 0,11563455 ! copper ion homeostasis GO:0055070 13 10 0,000 0,07000553 0,11555642 ! protein heterooligomerization GO:0051291 17 10 0,000 0,07000553 0,1154784 ! brain morphogenesis GO:0048854 23 10 0,000 0,07000553 0,11540048 ! segment specification GO:0007379 15 10 0,000 0,07000553 0,11532266 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,07000553 0,11524495 ! blastoderm segmentation GO:0007350 19 10 0,000 0,07000553 0,11516734 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,07000553 0,11508984 ! response to dsRNA GO:0043331 23 10 0,000 0,07000553 0,11501244 ! DNA ligation GO:0006266 18 10 0,000 0,07000553 0,11493515 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,07000553 0,11485796 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,07000553 0,11478088 ! melanosome localization GO:0032400 16 10 0,000 0,07000553 0,11470389 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,07000553 0,11462701 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,07000553 0,11455024 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,07000553 0,11447356 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,07000553 0,11439699 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,07000553 0,11432052 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,07000553 0,11424416 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07000553 0,11416789 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,07000553 0,11409173 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,07000553 0,11401567 ! salivary gland development GO:0007431 28 10 0,000 0,07000553 0,11393971 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,07000553 0,11386385 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,07000553 0,11378809 ! midbrain development GO:0030901 14 10 0,000 0,07000553 0,11371244 ! musculoskeletal movement GO:0050881 16 10 0,000 0,07000553 0,11363688 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,07000553 0,11356142 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,07000553 0,11348607 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,07000553 0,11341081 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,07000553 0,11333566 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,07000553 0,1132606 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,07000553 0,11318564 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,07000553 0,11311078 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,07000553 0,11303602 ! detection of calcium ion GO:0005513 24 10 0,000 0,07000553 0,11296136 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,07000553 0,1128868 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,07000553 0,11281234 ! cerebellar cortex development GO:0021695 16 10 0,000 0,07000553 0,11273797 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,07000553 0,11266371 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,07000553 0,11258954 ! adult behavior GO:0030534 104 60 1,000 0,07012867 0,11271338 ! kidney development GO:0001822 133 60 1,000 0,07012867 0,11263927 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,07217112 0,11584366 ! viral reproductive process GO:0022415 132 62 1,000 0,07423269 0,11907451 ! mesoderm development GO:0007498 128 63 1,000 0,076313 0,12233115 ! respiratory burst GO:0045730 17 11 0,000 0,07673172 0,1229217 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,07673172 0,12284115 ! neuron fate specification GO:0048665 18 11 0,000 0,07673172 0,12276071 ! telencephalon cell migration GO:0022029 23 11 0,000 0,07673172 0,12268036 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,07673172 0,12260013 ! thyroid gland development GO:0030878 26 11 0,000 0,07673172 0,12252 ! synapsis GO:0007129 14 11 0,000 0,07673172 0,12243997 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,07673172 0,12236005 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,07673172 0,12228023 ! response to pain GO:0048265 27 11 0,000 0,07673172 0,12220052 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,07673172 0,12212091 ! bone resorption GO:0045453 16 11 0,000 0,07673172 0,1220414 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,07673172 0,121962 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07673172 0,1218827 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07673172 0,12180351 ! melanocyte differentiation GO:0030318 20 11 0,000 0,07673172 0,12172441 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,07673172 0,12164542 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,07673172 0,12156654 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,07673172 0,12148775 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,07673172 0,12140907 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,07673172 0,12133048 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,07673172 0,121252 ! UV protection GO:0009650 20 11 0,000 0,07673172 0,12117362 ! adult heart development GO:0007512 16 11 0,000 0,07673172 0,12109535 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07673172 0,12101717 ! temperature homeostasis GO:0001659 18 11 0,000 0,07673172 0,1209391 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,07673172 0,12086112 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,07673172 0,12078325 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,07673172 0,12070547 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,07673172 0,1206278 ! regulation of organ growth GO:0046620 14 11 0,000 0,07673172 0,12055022 ! pigment granule localization GO:0051875 20 11 0,000 0,07673172 0,12047275 ! vasoconstriction GO:0042310 20 11 0,000 0,07673172 0,12039537 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,07673172 0,1203181 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07673172 0,12024092 ! embryonic axis specification GO:0000578 19 11 0,000 0,07673172 0,12016384 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,07673172 0,12008687 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07673172 0,12000999 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,07673172 0,1199332 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,07673172 0,11985652 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,07673172 0,11977993 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,07673172 0,11970345 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,07673172 0,11962706 ! prophase GO:0051324 17 11 0,000 0,07673172 0,11955076 ! nucleosome positioning GO:0016584 15 11 0,000 0,07673172 0,11947457 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,07673172 0,11939847 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,07673172 0,11932247 ! acid secretion GO:0046717 20 11 0,000 0,07673172 0,11924656 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07673172 0,11917075 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,07673172 0,11909504 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,07673172 0,11901943 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,07673172 0,11894391 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,07673172 0,11886848 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,07673172 0,11879315 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07673172 0,11871792 ! embryonic gut development GO:0048566 19 11 0,000 0,07673172 0,11864278 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,07673172 0,11856774 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,07673172 0,11849279 ! activation of innate immune response GO:0002218 16 11 0,000 0,07673172 0,11841794 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,07673172 0,11834318 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,07673172 0,11826852 ! lysogeny GO:0030069 22 11 0,000 0,07673172 0,11819395 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07673172 0,11811947 ! sequestering of metal ion GO:0051238 15 11 0,000 0,07673172 0,11804509 ! nucleus localization GO:0051647 22 11 0,000 0,07673172 0,1179708 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,08052833 0,12373001 ! regulation of cytokine biosynthetic process GO:0042035 108 66 1,000 0,08266262 0,12692946 ! gonad development GO:0008406 115 66 1,000 0,08266262 0,12684973 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,08340946 0,12791544 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,08340946 0,1278352 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,08340946 0,12775505 ! virus-host interaction GO:0019048 30 12 0,000 0,08340946 0,127675 ! mating GO:0007618 17 12 0,000 0,08340946 0,12759506 ! protein complex disassembly GO:0043241 28 12 0,000 0,08340946 0,12751521 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,08340946 0,12743546 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,08340946 0,12735581 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,08340946 0,12727627 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,08340946 0,12719682 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08340946 0,12711747 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,08340946 0,12703822 ! ventral spinal cord development GO:0021517 25 12 0,000 0,08340946 0,12695907 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,08340946 0,12688001 ! drug transport GO:0015893 16 12 0,000 0,08340946 0,12680106 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,08340946 0,1267222 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,08340946 0,12664345 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,08340946 0,12656478 ! polyamine metabolic process GO:0006595 18 12 0,000 0,08340946 0,12648622 ! mitotic spindle organization GO:0007052 23 12 0,000 0,08340946 0,12640776 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,08340946 0,12632939 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,08340946 0,12625112 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,08340946 0,12617294 ! lipid digestion GO:0044241 21 12 0,000 0,08340946 0,12609487 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,08340946 0,12601689 ! entry into host cell GO:0030260 34 12 0,000 0,08340946 0,125939 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08340946 0,12586121 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,08340946 0,12578352 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,08340946 0,12570592 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08340946 0,12562842 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,08340946 0,12555102 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,08340946 0,12547371 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,08340946 0,12539649 ! snRNA metabolic process GO:0016073 30 12 0,000 0,08340946 0,12531937 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,08340946 0,12524235 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,08340946 0,12516542 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08340946 0,12508858 ! fucose catabolic process GO:0019317 25 12 0,000 0,08340946 0,12501184 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,08340946 0,1249352 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,08340946 0,12485864 ! zymogen activation GO:0031638 18 12 0,000 0,08340946 0,12478218 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,08340946 0,12470582 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,08340946 0,12462954 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,08340946 0,12455336 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,08340946 0,12447728 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,08340946 0,12440128 ! defense response to fungus GO:0050832 15 12 0,000 0,08340946 0,12432538 ! lamellipodium assembly GO:0030032 24 12 0,000 0,08340946 0,12424958 ! response to cold GO:0009409 17 12 0,000 0,08340946 0,12417386 ! establishment of cell polarity GO:0030010 21 12 0,000 0,08340946 0,12409824 ! regulation of synapse organization GO:0050807 18 12 0,000 0,08340946 0,1240227 ! chromosome segregation GO:0007059 127 67 1,000 0,08481416 0,12603466 ! secondary metabolic process GO:0019748 125 67 1,000 0,08481416 0,12595805 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,08481416 0,12588152 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,0869826 0,12902155 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,0869826 0,12894326 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,0869826 0,12886506 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,0869826 0,12878696 ! viral reproduction GO:0016032 142 68 1,000 0,0869826 0,12870896 ! regulation of lipase activity GO:0060191 137 68 1,000 0,0869826 0,12863105 ! adaptive immune response GO:0002250 126 68 1,000 0,0869826 0,12855323 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! homeostasis of number of cells GO:0048872 131 69 1,000 0,08916759 0,13170279 ! developmental maturation GO:0021700 128 69 1,000 0,08916759 0,13162321 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,09003908 0,13282939 ! cGMP metabolic process GO:0046068 18 13 0,000 0,09003908 0,13274923 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,09003908 0,13266916 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,09003908 0,13258919 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,09003908 0,13250932 ! peroxisomal transport GO:0043574 28 13 0,000 0,09003908 0,13242954 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,09003908 0,13234986 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,09003908 0,13227028 ! organelle fusion GO:0048284 36 13 0,000 0,09003908 0,13219079 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,09003908 0,13211139 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,09003908 0,1320321 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,09003908 0,13195289 ! endocrine pancreas development GO:0031018 25 13 0,000 0,09003908 0,13187378 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,09003908 0,13179477 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,09003908 0,13171585 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,09003908 0,13163703 ! methionine metabolic process GO:0006555 31 13 0,000 0,09003908 0,1315583 ! plasma membrane organization GO:0007009 27 13 0,000 0,09003908 0,13147966 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,09003908 0,13140112 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,09003908 0,13132267 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,09003908 0,13124432 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,09003908 0,13116605 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,09003908 0,13108789 ! cytokine metabolic process GO:0042107 24 13 0,000 0,09003908 0,13100981 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,09003908 0,13093183 ! exocrine system development GO:0035272 34 13 0,000 0,09003908 0,13085394 ! monoamine transport GO:0015844 21 13 0,000 0,09003908 0,13077614 ! L-glutamate transport GO:0015813 30 13 0,000 0,09003908 0,13069844 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,09003908 0,13062083 ! protein homotetramerization GO:0051289 24 13 0,000 0,09003908 0,13054331 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,09003908 0,13046588 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,09003908 0,13038854 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,09003908 0,1303113 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,09003908 0,13023415 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,09003908 0,13015708 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,09003908 0,13008011 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,09003908 0,13000323 ! regulation of epidermis development GO:0045682 19 13 0,000 0,09003908 0,12992645 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,09003908 0,12984975 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,09003908 0,12977314 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,09003908 0,12969662 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,09003908 0,1296202 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,09003908 0,12954386 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,09003908 0,12946761 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,09003908 0,12939145 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,09003908 0,12931539 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,09003908 0,12923941 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,09003908 0,12916352 ! insulin secretion GO:0030073 24 13 0,000 0,09003908 0,12908772 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,09003908 0,12901201 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,09003908 0,12893638 ! acrosome reaction GO:0007340 19 13 0,000 0,09003908 0,12886085 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,09003908 0,12878541 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,09003908 0,12871005 ! activation of immune response GO:0002253 120 70 1,000 0,09136877 0,13053444 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,0935858 0,13362367 ! carbohydrate transport GO:0008643 114 72 1,000 0,09581834 0,13673142 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,09581834 0,1366516 ! rRNA transcription GO:0009303 28 14 0,000 0,09662094 0,13771584 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,09662094 0,13763554 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,09662094 0,13755533 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,09662094 0,13747522 ! non-recombinational repair GO:0000726 29 14 0,000 0,09662094 0,1373952 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,09662094 0,13731527 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,09662094 0,13723544 ! RNA polyadenylation GO:0043631 32 14 0,000 0,09662094 0,13715569 ! lipid localization GO:0010876 32 14 0,000 0,09662094 0,13707604 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,09662094 0,13699649 ! regulated secretory pathway GO:0045055 24 14 0,000 0,09662094 0,13691702 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,09662094 0,13683765 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,09662094 0,13675837 ! arginine metabolic process GO:0006525 21 14 0,000 0,09662094 0,13667918 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,09662094 0,13660009 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,09662094 0,13652108 ! regulation of heart rate GO:0002027 25 14 0,000 0,09662094 0,13644217 ! organic alcohol transport GO:0015850 29 14 0,000 0,09662094 0,13636334 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,09662094 0,13628461 ! embryo implantation GO:0007566 30 14 0,000 0,09662094 0,13620597 ! neutral amino acid transport GO:0015804 28 14 0,000 0,09662094 0,13612742 ! bone mineralization GO:0030282 18 14 0,000 0,09662094 0,13604896 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,09662094 0,13597059 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,09662094 0,13589231 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,09662094 0,13581412 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,09662094 0,13573603 ! regulation of cellular pH GO:0030641 27 14 0,000 0,09662094 0,13565802 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,09662094 0,1355801 ! ribosome assembly GO:0042255 18 14 0,000 0,09662094 0,13550227 ! cerebellum development GO:0021549 23 14 0,000 0,09662094 0,13542453 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,09662094 0,13534687 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,09662094 0,13526931 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,09662094 0,13519184 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,09662094 0,13511445 ! NADP metabolic process GO:0006739 24 14 0,000 0,09662094 0,13503716 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,09662094 0,13495995 ! oxygen transport GO:0015671 22 14 0,000 0,09662094 0,13488283 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09662094 0,1348058 ! male genitalia development GO:0030539 26 14 0,000 0,09662094 0,13472885 ! regulation of axon extension GO:0030516 43 14 0,000 0,09662094 0,134652 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,09662094 0,13457523 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,09662094 0,13449855 ! humoral immune response GO:0006959 115 73 1,000 0,09806604 0,13643243 ! regulation of immune effector process GO:0002697 156 73 1,000 0,09806604 0,13635478 ! organelle localization GO:0051640 155 74 1,000 0,10032858 0,13942135 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,10260563 0,14250458 ! rhythmic process GO:0048511 142 75 1,000 0,10260563 0,14242361 ! lactation GO:0007595 30 15 0,000 0,10315537 0,14310538 ! reproductive cellular process GO:0048610 22 15 0,000 0,10315537 0,14302416 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10315537 0,14294303 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,10315537 0,142862 ! superoxide anion generation GO:0042554 22 15 0,000 0,10315537 0,14278106 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,10315537 0,14270021 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,10315537 0,14261945 ! copper ion transport GO:0006825 22 15 0,000 0,10315537 0,14253878 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,10315537 0,14245821 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,10315537 0,14237772 ! sulfate transport GO:0008272 27 15 0,000 0,10315537 0,14229733 ! response to cAMP GO:0051591 25 15 0,000 0,10315537 0,14221703 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,10315537 0,14213681 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,10315537 0,14205669 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,10315537 0,14197666 ! response to hexose stimulus GO:0009746 25 15 0,000 0,10315537 0,14189672 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,10315537 0,14181687 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,10315537 0,1417371 ! vesicle coating GO:0006901 38 15 0,000 0,10315537 0,14165743 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,10315537 0,14157785 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,10315537 0,14149835 ! regulation of exocytosis GO:0017157 26 15 0,000 0,10315537 0,14141895 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,10315537 0,14133964 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,10315537 0,14126041 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,10315537 0,14118127 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,10315537 0,14110222 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,10315537 0,14102326 ! regulation of vasodilation GO:0042312 27 15 0,000 0,10315537 0,14094439 ! water homeostasis GO:0030104 28 15 0,000 0,10315537 0,14086561 ! cofactor transport GO:0051181 30 15 0,000 0,10315537 0,14078691 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10315537 0,1407083 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,10315537 0,14062978 ! intestinal absorption GO:0050892 31 15 0,000 0,10315537 0,14055135 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10315537 0,140473 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,10315537 0,14039475 ! heme biosynthetic process GO:0006783 33 15 0,000 0,10315537 0,14031658 ! cell killing GO:0001906 32 15 0,000 0,10315537 0,14023849 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,10315537 0,14016049 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,10315537 0,14008258 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,10315537 0,14000476 ! actin filament polymerization GO:0030041 27 15 0,000 0,10315537 0,13992702 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,10315537 0,13984937 ! learning or memory GO:0007611 161 76 1,000 0,10489686 0,14213146 ! regulation of catabolic process GO:0009894 173 77 1,000 0,10720194 0,14517424 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,10964272 0,14839732 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,10964272 0,14831515 ! bone remodeling GO:0046849 28 16 0,000 0,10964272 0,14823308 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,10964272 0,14815109 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,10964272 0,14806919 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10964272 0,14798738 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,10964272 0,14790567 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,10964272 0,14782404 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,10964272 0,14774251 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,10964272 0,14766106 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,10964272 0,14757971 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,10964272 0,14749844 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,10964272 0,14741726 ! glutamate metabolic process GO:0006536 25 16 0,000 0,10964272 0,14733618 ! pituitary gland development GO:0021983 30 16 0,000 0,10964272 0,14725518 ! response to osmotic stress GO:0006970 27 16 0,000 0,10964272 0,14717427 ! lysosomal transport GO:0007041 31 16 0,000 0,10964272 0,14709345 ! fructose metabolic process GO:0006000 25 16 0,000 0,10964272 0,14701271 ! L-amino acid transport GO:0015807 33 16 0,000 0,10964272 0,14693207 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10964272 0,14685152 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,10964272 0,14677105 ! intermediate filament-based process GO:0045103 36 16 0,000 0,10964272 0,14669067 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,10964272 0,14661038 ! axon cargo transport GO:0008088 46 16 0,000 0,10964272 0,14653018 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,10964272 0,14645006 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,10964272 0,14637004 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,10964272 0,1462901 ! DNA replication initiation GO:0006270 28 16 0,000 0,10964272 0,14621024 ! neuron recognition GO:0008038 40 16 0,000 0,10964272 0,14613048 ! mRNA splice site selection GO:0006376 44 16 0,000 0,10964272 0,1460508 ! tissue regeneration GO:0042246 27 16 0,000 0,10964272 0,14597121 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,10964272 0,1458917 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,10964272 0,14581228 ! biomineral formation GO:0031214 22 16 0,000 0,10964272 0,14573295 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,10964272 0,14565371 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10964272 0,14557455 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,10964272 0,14549547 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,10964272 0,14541649 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,10964272 0,14533758 ! peptide hormone processing GO:0016486 27 16 0,000 0,10964272 0,14525877 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,11185241 0,14810592 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,11185241 0,14802569 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,11185241 0,14794555 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,11419717 0,15096519 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,11419717 0,15088355 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,11608333 0,15329274 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,11608333 0,15320992 ! signal complex assembly GO:0007172 47 17 0,000 0,11608333 0,15312719 ! filopodium assembly GO:0046847 42 17 0,000 0,11608333 0,15304456 ! gene silencing by RNA GO:0031047 38 17 0,000 0,11608333 0,15296201 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,11608333 0,15287955 ! glial cell development GO:0021782 28 17 0,000 0,11608333 0,15279718 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,11608333 0,1527149 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,11608333 0,1526327 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,11608333 0,1525506 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,11608333 0,15246858 ! myoblast differentiation GO:0045445 50 17 0,000 0,11608333 0,15238666 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,11608333 0,15230481 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,11608333 0,15222306 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,11608333 0,1521414 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,11608333 0,15205982 ! NAD metabolic process GO:0019674 33 17 0,000 0,11608333 0,15197833 ! membrane budding GO:0006900 42 17 0,000 0,11608333 0,15189693 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,11608333 0,15181561 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,11608333 0,15173438 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,11608333 0,15165324 ! genitalia development GO:0048806 32 17 0,000 0,11608333 0,15157219 ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,11608333 0,15149122 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,11608333 0,15141034 ! steroid catabolic process GO:0006706 34 17 0,000 0,11608333 0,15132954 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,11608333 0,15124883 ! gas transport GO:0015669 26 17 0,000 0,11608333 0,15116821 ! organic cation transport GO:0015695 32 17 0,000 0,11608333 0,15108767 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,11608333 0,15100722 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,12130588 0,15771702 ! inorganic anion transport GO:0015698 156 83 1,000 0,12130588 0,15763313 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,12247752 0,15907102 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,12247752 0,1589865 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,12247752 0,15890206 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,12247752 0,15881772 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,12247752 0,15873347 ! adult walking behavior GO:0007628 36 18 0,000 0,12247752 0,1586493 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,12247752 0,15856523 ! centrosome cycle GO:0007098 26 18 0,000 0,12247752 0,15848124 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,12247752 0,15839735 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,12247752 0,15831354 ! glycine metabolic process GO:0006544 30 18 0,000 0,12247752 0,15822982 ! glutamine metabolic process GO:0006541 29 18 0,000 0,12247752 0,15814619 ! response to retinoic acid GO:0032526 31 18 0,000 0,12247752 0,15806264 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,12247752 0,15797919 ! DNA integration GO:0015074 32 18 0,000 0,12247752 0,15789582 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,12247752 0,15781254 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,12247752 0,15772935 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,12247752 0,15764625 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,12247752 0,15756324 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,12247752 0,15748031 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,12247752 0,15739747 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,12247752 0,15731471 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,12247752 0,15723205 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,12247752 0,15714947 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,12247752 0,15706697 ! detection of bacterium GO:0016045 22 18 0,000 0,12247752 0,15698457 ! microspike assembly GO:0030035 46 18 0,000 0,12247752 0,15690225 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,12247752 0,15682001 ! response to metal ion GO:0010038 158 84 1,000 0,12369927 0,15830137 ! response to nutrient GO:0007584 135 84 1,000 0,12369927 0,15821849 ! regulation of ligase activity GO:0051340 147 84 1,000 0,12369927 0,1581357 ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,12610407 0,16112566 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,12882564 0,16451701 ! positive regulation of translation GO:0045727 31 19 0,000 0,12882564 0,16443106 ! negative regulation of defense response GO:0031348 27 19 0,000 0,12882564 0,16434519 ! neuron maturation GO:0042551 46 19 0,000 0,12882564 0,16425942 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,12882564 0,16417373 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,12882564 0,16408813 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,12882564 0,16400263 GO:0019692|deoxyribose phosphate metabolic process, ! memory GO:0007613 34 19 0,000 0,12882564 0,16391721 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,12882564 0,16383188 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,12882564 0,16374664 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,12882564 0,16366149 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,12882564 0,16357642 ! cerebral cortex development GO:0021987 40 19 0,000 0,12882564 0,16349145 ! pigmentation during development GO:0048066 42 19 0,000 0,12882564 0,16340656 ! response to vitamin A GO:0033189 32 19 0,000 0,12882564 0,16332176 ! heme metabolic process GO:0042168 40 19 0,000 0,12882564 0,16323705 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,12882564 0,16315243 ! response to fungus GO:0009620 26 19 0,000 0,12882564 0,1630679 ! peptide cross-linking GO:0018149 39 19 0,000 0,12882564 0,16298345 ! protein export from nucleus GO:0006611 40 19 0,000 0,12882564 0,16289909 ! heart process GO:0003015 32 19 0,000 0,12882564 0,16281482 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,12882564 0,16273063 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,12882564 0,16264653 ! visual learning GO:0008542 38 19 0,000 0,12882564 0,16256252 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,12882564 0,1624786 ! vitamin transport GO:0051180 31 19 0,000 0,12882564 0,16239476 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,12882564 0,16231101 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,12882564 0,16222734 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,12882564 0,16214376 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,12882564 0,16206027 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,12882564 0,16197686 ! cilium assembly GO:0042384 38 19 0,000 0,12882564 0,16189354 ! peptide hormone secretion GO:0030072 32 19 0,000 0,12882564 0,1618103 ! regulation of protein transport GO:0051223 165 87 1,000 0,13094678 0,16439003 GO:0070201|regulation of establishment of protein localization, ! protein secretion GO:0009306 45 20 0,000 0,13512801 0,169552 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,13512801 0,16946496 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,13512801 0,16937801 ! positive regulation of ossification GO:0045778 50 20 0,000 0,13512801 0,16929115 ! skin development GO:0043588 42 20 0,000 0,13512801 0,16920438 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,13512801 0,16911769 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,13512801 0,1690311 ! response to vitamin GO:0033273 36 20 0,000 0,13512801 0,16894459 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,13512801 0,16885818 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,13512801 0,16877185 ! bile acid metabolic process GO:0008206 34 20 0,000 0,13512801 0,16868561 ! retinoid metabolic process GO:0001523 34 20 0,000 0,13512801 0,16859946 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,13512801 0,16851339 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,13512801 0,16842742 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,13512801 0,16834153 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,13512801 0,16825573 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,13512801 0,16817001 ! peptide secretion GO:0002790 38 20 0,000 0,13512801 0,16808439 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,13512801 0,16799885 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,13512801 0,1679134 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,13512801 0,16782803 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,13512801 0,16774275 ! cell-cell junction organization GO:0045216 43 20 0,000 0,13512801 0,16765756 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,13512801 0,16757246 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,13512801 0,16748744 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,13512801 0,1674025 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,13512801 0,16731766 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,13512801 0,1672329 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,13512801 0,16714822 ! response to inorganic substance GO:0010035 173 90 1,000 0,13828938 0,17097214 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,14138497 0,17471092 ! hormone secretion GO:0046879 39 21 0,000 0,14138497 0,17462259 ! cAMP metabolic process GO:0046058 41 21 0,000 0,14138497 0,17453435 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,14138497 0,1744462 ! smooth muscle contraction GO:0006939 48 21 0,000 0,14138497 0,17435814 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,14138497 0,17427017 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,14138497 0,17418229 ! plasma membrane fusion GO:0045026 33 21 0,000 0,14138497 0,1740945 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,14138497 0,17400679 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,14138497 0,17391917 ! sensory perception of pain GO:0019233 33 21 0,000 0,14138497 0,17383165 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,14138497 0,17374421 ! diencephalon development GO:0021536 36 21 0,000 0,14138497 0,17365685 ! collagen fibril organization GO:0030199 62 21 0,000 0,14138497 0,17356959 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,14138497 0,17348241 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,14138497 0,17339532 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,14138497 0,17330832 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,14138497 0,1732214 ! collagen catabolic process GO:0030574 29 21 0,000 0,14138497 0,17313458 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,14138497 0,17304784 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,14138497 0,17296118 ! sperm-egg recognition GO:0035036 23 21 0,000 0,14138497 0,17287461 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,14138497 0,17278813 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,14759683 0,18028953 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,14759683 0,18019943 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,14759683 0,18010942 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,14759683 0,1800195 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,14759683 0,17992967 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,14759683 0,17983993 ! microtubule-based transport GO:0010970 59 22 0,000 0,14759683 0,17975028 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,14759683 0,17966072 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,14759683 0,17957125 ! vacuolar transport GO:0007034 41 22 0,000 0,14759683 0,17948186 ! fucose metabolic process GO:0006004 44 22 0,000 0,14759683 0,17939257 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,14759683 0,17930336 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,14759683 0,17921425 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,14759683 0,17912522 ! cytolysis GO:0019835 27 22 0,000 0,14759683 0,17903628 ! vasodilation GO:0042311 40 22 0,000 0,14759683 0,17894743 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,14759683 0,17885866 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,14759683 0,17876999 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,14759683 0,1786814 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,14759683 0,1785929 ! sarcomere organization GO:0045214 32 22 0,000 0,14759683 0,17850449 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,14759683 0,17841616 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,14759683 0,17832793 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,14759683 0,17823978 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,14759683 0,17815171 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,14821464 0,17880907 ! response to protein stimulus GO:0051789 158 96 1,000 0,15323044 0,18476899 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,15376393 0,18532081 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,15376393 0,18522943 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,15376393 0,18513814 ! glycerol metabolic process GO:0006071 40 23 0,000 0,15376393 0,18504694 ! viral genome replication GO:0019079 44 23 0,000 0,15376393 0,18495583 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,15376393 0,1848648 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,15376393 0,18477387 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,15376393 0,18468303 ! axis specification GO:0009798 43 23 0,000 0,15376393 0,18459228 ! visual behavior GO:0007632 46 23 0,000 0,15376393 0,18450161 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,15376393 0,18441104 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,15376393 0,18432055 ! peroxisome organization GO:0007031 43 23 0,000 0,15376393 0,18423015 ! lysosome organization GO:0007040 47 23 0,000 0,15376393 0,18413984 ! vesicle targeting GO:0006903 49 23 0,000 0,15376393 0,18404962 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,15376393 0,18395949 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,15376393 0,18386945 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,15376393 0,18377949 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,15376393 0,18368963 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,15376393 0,18359985 ! fatty acid transport GO:0015908 47 23 0,000 0,15376393 0,18351015 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,15376393 0,18342055 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,15376393 0,18333103 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,15376393 0,1832416 ! hormone transport GO:0009914 41 23 0,000 0,15376393 0,18315226 ! cell-cell recognition GO:0009988 28 23 0,000 0,15376393 0,183063 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,15376393 0,18297384 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,15376393 0,18288475 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,15376393 0,18279576 ! transcription initiation GO:0006352 171 97 1,000 0,15575074 0,18506764 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,15988658 0,18988961 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,15988658 0,18979734 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,15988658 0,18970516 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,15988658 0,18961307 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,15988658 0,18952107 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,15988658 0,18942916 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,15988658 0,18933733 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,15988658 0,1892456 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,15988658 0,18915396 GO:0051693|actin filament capping, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,15988658 0,1890624 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,15988658 0,18897093 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,15988658 0,18887955 ! membrane depolarization GO:0051899 45 24 0,000 0,15988658 0,18878826 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,15988658 0,18869706 ! platelet activation GO:0030168 41 24 0,000 0,15988658 0,18860595 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,15988658 0,18851492 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,15988658 0,18842398 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,15988658 0,18833313 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,15988658 0,18824237 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,15988658 0,18815169 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,15988658 0,18806111 ! regulation of amine transport GO:0051952 41 24 0,000 0,15988658 0,18797061 ! positive regulation of immune response GO:0050778 175 100 1,000 0,16335826 0,19195971 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,1659651 0,19492921 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,1659651 0,19483554 ! phototransduction GO:0007602 37 25 0,000 0,1659651 0,19474196 ! keratinization GO:0031424 37 25 0,000 0,1659651 0,19464846 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,1659651 0,19455506 ! vacuole organization GO:0007033 49 25 0,000 0,1659651 0,19446175 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,1659651 0,19436853 ! receptor metabolic process GO:0043112 53 25 0,000 0,1659651 0,1942754 ! chromosome condensation GO:0030261 48 25 0,000 0,1659651 0,19418235 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,1659651 0,1940894 ! interaction with host GO:0051701 66 25 0,000 0,1659651 0,19399653 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,1659651 0,19390375 ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,1659651 0,19381107 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,1659651 0,19371847 ! liver development GO:0001889 55 25 0,000 0,1659651 0,19362596 ! protein tetramerization GO:0051262 57 25 0,000 0,1659651 0,19353353 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,17199982 0,20047498 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,17199982 0,20037938 ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,17199982 0,20028387 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,17199982 0,20018845 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,17199982 0,20009312 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,17199982 0,19999788 ! digestive system process GO:0022600 49 26 0,000 0,17199982 0,19990274 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,17199982 0,19980768 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,17199982 0,19971272 ! osteoblast differentiation GO:0001649 63 26 0,000 0,17199982 0,19961784 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,17199982 0,19952306 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,17199982 0,19942836 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,17199982 0,19933375 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,17199982 0,19923924 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,17199982 0,19914481 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,17199982 0,19905048 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,17199982 0,19895623 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,17199982 0,19886207 ! telomere organization GO:0032200 46 26 0,000 0,17199982 0,198768 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,17199982 0,19867402 ! neural tube closure GO:0001843 58 26 0,000 0,17199982 0,19858013 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,17199982 0,19848633 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,17199982 0,19839261 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,17199982 0,19829899 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,17799103 0,20510948 ! embryonic pattern specification GO:0009880 49 27 0,000 0,17799103 0,20501278 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,17799103 0,20491616 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,17799103 0,20481964 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,17799103 0,20472321 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,17799103 0,20462687 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,17799103 0,20453062 ! iron ion transport GO:0006826 65 27 0,000 0,17799103 0,20443446 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,17799103 0,20433839 ! superoxide metabolic process GO:0006801 41 27 0,000 0,17799103 0,20424241 ! tube lumen formation GO:0035148 59 27 0,000 0,17799103 0,20414652 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,17799103 0,20405073 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,17799103 0,20395502 ! neuron fate commitment GO:0048663 52 28 0,000 0,18393907 0,21067189 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,18393907 0,21057317 ! vesicle docking GO:0048278 55 28 0,000 0,18393907 0,21047454 ! circadian rhythm GO:0007623 56 28 0,000 0,18393907 0,210376 ! fat cell differentiation GO:0045444 57 28 0,000 0,18393907 0,21027756 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,18393907 0,21017921 ! sperm motility GO:0030317 37 28 0,000 0,18393907 0,21008095 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,18393907 0,20998278 ! base-excision repair GO:0006284 41 28 0,000 0,18393907 0,2098847 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,18393907 0,20978672 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,18393907 0,20968882 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,18393907 0,20959102 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,18393907 0,20949331 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,18393907 0,20939569 ! glutathione metabolic process GO:0006749 42 28 0,000 0,18393907 0,20929816 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,18393907 0,20920072 ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,18393907 0,20910337 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,18393907 0,20900611 ! translational initiation GO:0006413 66 29 0,000 0,18984423 0,21561574 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,18984423 0,21551554 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,18984423 0,21541544 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,18984423 0,21531544 ! primary neural tube formation GO:0014020 61 29 0,000 0,18984423 0,21521552 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,18984423 0,2151157 ! synaptogenesis GO:0007416 46 29 0,000 0,18984423 0,21501597 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,18984423 0,21491633 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,18984423 0,21481679 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,19570682 0,22134804 ! phenol metabolic process GO:0018958 56 30 0,000 0,19570682 0,22124561 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,19570682 0,22114328 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,19570682 0,22104104 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,19570682 0,22093889 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,19570682 0,22083684 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,19570682 0,22073489 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,19570682 0,22063303 ! acute-phase response GO:0006953 50 30 0,000 0,19570682 0,22053126 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,19570682 0,22042958 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,19570682 0,220328 ! myofibril assembly GO:0030239 50 30 0,000 0,19570682 0,22022652 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,19570682 0,22012512 ! cell fate determination GO:0001709 64 30 0,000 0,19570682 0,22002382 ! phospholipid transport GO:0015914 65 30 0,000 0,19570682 0,21992262 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,19570682 0,2198215 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,19570682 0,21972048 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,19570682 0,21961955 ! regulation of coagulation GO:0050818 52 30 0,000 0,19570682 0,21951872 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,20152716 0,22594348 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,20152716 0,22583984 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,20152716 0,22573629 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,20152716 0,22563283 ! regulation of innate immune response GO:0045088 57 31 0,000 0,20152716 0,22552947 ! peptide transport GO:0015833 60 31 0,000 0,20152716 0,22542621 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,20152716 0,22532304 ! detection of light stimulus GO:0009583 44 31 0,000 0,20152716 0,22521996 ! natural killer cell activation GO:0030101 50 31 0,000 0,20152716 0,22511698 ! cofactor catabolic process GO:0051187 54 31 0,000 0,20152716 0,2250141 ! eye morphogenesis GO:0048592 65 31 0,000 0,20152716 0,2249113 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,20730553 0,23125453 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,20730553 0,23114898 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,20730553 0,23104353 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,20730553 0,23093818 ! muscle cell development GO:0055001 52 32 0,000 0,20730553 0,23083292 ! BMP signaling pathway GO:0030509 71 32 0,000 0,20730553 0,23072775 ! regulation of pH GO:0006885 56 33 0,000 0,21304226 0,23700466 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,21304226 0,23689678 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,21304226 0,236789 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,21304226 0,23668132 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,21304226 0,23657374 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,21304226 0,23646626 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,21304226 0,23635887 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,21304226 0,23625158 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,21304226 0,23614439 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,21304226 0,23603729 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,21304226 0,2359303 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,21304226 0,23582339 ! glial cell differentiation GO:0010001 67 34 0,000 0,21873762 0,24201812 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,21873762 0,24190856 ! cholesterol transport GO:0030301 62 34 0,000 0,21873762 0,2417991 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,21873762 0,24168974 ! spliceosome assembly GO:0000245 75 34 0,000 0,21873762 0,24158048 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,21873762 0,24147131 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,21873762 0,24136225 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,21873762 0,24125328 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,21873762 0,24114441 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,22439193 0,24726634 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,22439193 0,24715486 ! negative regulation of secretion GO:0051048 68 35 0,000 0,22439193 0,24704348 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,22439193 0,2469322 ! membrane docking GO:0022406 69 35 0,000 0,22439193 0,24682102 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,22439193 0,24670994 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,22439193 0,24659896 ! ceramide metabolic process GO:0006672 72 35 0,000 0,22439193 0,24648808 ! sterol transport GO:0015918 63 35 0,000 0,22439193 0,2463773 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,22439193 0,24626661 ! vesicle localization GO:0051648 70 35 0,000 0,22439193 0,24615603 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,23000547 0,25220079 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,23000547 0,25208765 ! protein targeting to membrane GO:0006612 75 36 0,000 0,23000547 0,2519746 ! regulation of proteolysis GO:0030162 77 36 0,000 0,23000547 0,25186166 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,23000547 0,25174882 ! aerobic respiration GO:0009060 56 36 0,000 0,23000547 0,25163608 ! cytokine production GO:0001816 68 36 0,000 0,23000547 0,25152344 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,23000547 0,2514109 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,23557854 0,25738747 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,23557854 0,25727241 ! actomyosin structure organization GO:0031032 68 37 0,000 0,23557854 0,25715745 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,23557854 0,2570426 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,24111143 0,26296216 ! organic anion transport GO:0015711 82 38 0,000 0,24111143 0,26284481 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,24111143 0,26272758 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,24111143 0,26261044 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,24111143 0,26249342 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,24111143 0,26237649 ! spermatid development GO:0007286 69 38 0,000 0,24111143 0,26225967 ! neural tube formation GO:0001841 79 38 0,000 0,24111143 0,26214296 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,24660443 0,26799583 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,24660443 0,26787667 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,24660443 0,26775761 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,24660443 0,26763866 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,24660443 0,26751981 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,24660443 0,26740107 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,24660443 0,26728244 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,25205782 0,27307195 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,25205782 0,27295091 ! lipid homeostasis GO:0055088 75 40 0,000 0,25205782 0,27282998 ! mismatch repair GO:0006298 58 40 0,000 0,25205782 0,27270915 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,25205782 0,27258843 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,25205782 0,27246781 ! RNA export from nucleus GO:0006405 61 41 0,000 0,25747189 0,27819718 ! mRNA catabolic process GO:0006402 79 41 0,000 0,25747189 0,27807419 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,25747189 0,27795132 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,25747189 0,27782855 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,25747189 0,27770588 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,25747189 0,27758333 ! gliogenesis GO:0042063 91 41 0,000 0,25747189 0,27746089 ! feeding behavior GO:0007631 69 41 0,000 0,25747189 0,27733855 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,25747189 0,27721632 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,25747189 0,2770942 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,25747189 0,27697218 ! spermatid differentiation GO:0048515 73 41 0,000 0,25747189 0,27685028 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,25747189 0,27672848 ! RNA modification GO:0009451 64 41 0,000 0,25747189 0,27660678 ! organic ether metabolic process GO:0018904 59 42 0,000 0,26284692 0,28225716 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,26284692 0,28213314 ! regulation of protein secretion GO:0050708 77 42 0,000 0,26284692 0,28200924 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,26284692 0,28188544 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,26818319 0,28748203 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,26818319 0,28735594 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,26818319 0,28722996 ! regulation of tube size GO:0035150 76 43 0,000 0,26818319 0,28710409 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,26818319 0,28697834 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,26818319 0,28685269 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,26818319 0,28672715 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,26818319 0,28660172 ! ion transmembrane transport GO:0034220 79 43 0,000 0,26818319 0,28647641 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,27348099 0,29200789 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,27348099 0,29188032 ! striated muscle contraction GO:0006941 85 44 0,000 0,27348099 0,29175286 ! phagocytosis GO:0006909 105 44 0,000 0,27348099 0,29162551 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,27348099 0,29149828 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,27874057 0,2969748 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,27874057 0,29684535 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,27874057 0,296716 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,27874057 0,29658677 ! maintenance of location in cell GO:0051651 101 45 0,000 0,27874057 0,29645765 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,28396223 0,30187978 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,28396223 0,30174847 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,28396223 0,30161728 ! neural tube development GO:0021915 91 47 0,000 0,28914624 0,30699011 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,28914624 0,30685676 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,29429285 0,31218299 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,29429285 0,3120475 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,29429285 0,31191212 ! response to calcium ion GO:0051592 94 49 0,000 0,29940235 0,31718991 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,29940235 0,31705242 ! JNK cascade GO:0007254 106 49 0,000 0,29940235 0,31691505 ! protein homooligomerization GO:0051260 84 49 0,000 0,29940235 0,3167778 ! regulation of ion transport GO:0043269 86 50 0,000 0,304475 0,32200537 ! endocrine system development GO:0035270 109 50 0,000 0,304475 0,32186604 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,304475 0,32172682 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,304475 0,32158773 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,304475 0,32144875 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,304475 0,3213099 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,30951106 0,32648338 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,30951106 0,32634247 ! peptide metabolic process GO:0006518 80 51 0,000 0,30951106 0,32620169 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,31451079 0,3313281 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,31451079 0,33118529 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,31451079 0,3310426 ! excretion GO:0007588 87 52 0,000 0,31451079 0,33090003 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,31451079 0,33075758 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,31451079 0,33061526 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,31451079 0,33047306 ! amino acid activation GO:0043038 98 52 0,000 0,31451079 0,33033098 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,31947447 0,33540014 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,31947447 0,33525607 ! regulation of translational initiation GO:0006446 87 54 0,000 0,32440234 0,3402812 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,32440234 0,34013515 ! membrane fusion GO:0006944 122 54 0,000 0,32440234 0,33998924 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,32440234 0,33984344 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,32440234 0,33969778 ! RNA catabolic process GO:0006401 103 55 0,000 0,32929466 0,34467303 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,32929466 0,34452542 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,32929466 0,34437794 ! cell recognition GO:0008037 98 55 0,000 0,32929466 0,34423058 ! cell maturation GO:0048469 107 55 0,000 0,32929466 0,34408334 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,32929466 0,34393624 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,3341517 0,34886008 ! RNA elongation GO:0006354 90 56 0,000 0,3341517 0,34871106 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,33897369 0,35359211 ! regulation of actin filament length GO:0030832 118 58 0,000 0,3437609 0,35843273 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,3437609 0,35827982 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,3437609 0,35812703 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,3437609 0,35797438 ! maintenance of location GO:0051235 124 58 0,000 0,3437609 0,35782185 ! nuclear export GO:0051168 110 59 0,000 0,34851358 0,36261443 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,35323197 0,36736726 ! regulation of endocytosis GO:0030100 104 60 0,000 0,35323197 0,36721093 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,35323197 0,36705474 ! positive regulation of secretion GO:0051047 110 61 0,000 0,35791632 0,37176427 ! regulation of cellular component size GO:0032535 125 61 0,000 0,35791632 0,37160627 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,35791632 0,37144841 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,35791632 0,37129068 ! camera-type eye development GO:0043010 126 61 0,000 0,35791632 0,37113309 ! proton transport GO:0015992 117 61 0,000 0,35791632 0,37097563 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,36256687 0,37563649 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,36256687 0,37547726 ! tRNA processing GO:0008033 102 62 0,000 0,36256687 0,37531816 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,36718386 0,37993654 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,36718386 0,37977569 ! hydrogen transport GO:0006818 121 64 0,000 0,37176755 0,38435384 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,37176755 0,38419125 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,37631816 0,3887295 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,37631816 0,3885652 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,37631816 0,38840104 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,38083594 0,39289789 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,38532112 0,39735732 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,38977393 0,40177963 ! extracellular matrix organization GO:0030198 146 68 0,000 0,38977393 0,40161017 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,38977393 0,40144086 ! cell projection assembly GO:0030031 138 68 0,000 0,38977393 0,40127169 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,39419461 0,40565183 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,39419461 0,40548103 ! single fertilization GO:0007338 83 69 0,000 0,39419461 0,40531037 ! cell redox homeostasis GO:0045454 114 70 0,000 0,39858339 0,4096505 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,39858339 0,40947823 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,4029405 0,41378043 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,4029405 0,41360657 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,40726617 0,41787117 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,40726617 0,41769574 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,40726617 0,41752046 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,40726617 0,41734532 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,41156061 0,42156922 ! acute inflammatory response GO:0002526 118 74 0,000 0,41582407 0,42575783 ! amino acid transport GO:0006865 148 74 0,000 0,41582407 0,42557947 ! transition metal ion transport GO:0000041 143 75 0,000 0,42005675 0,42973142 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,42005675 0,42955154 ! eye development GO:0001654 155 75 0,000 0,42005675 0,42937181 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,42425888 0,43348576 ! regulation of blood pressure GO:0008217 134 76 0,000 0,42425888 0,43330453 ! amine catabolic process GO:0009310 136 77 0,000 0,42843068 0,43738243 ! neurotransmitter transport GO:0006836 142 77 0,000 0,42843068 0,43719973 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,42843068 0,43701718 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,42843068 0,43683479 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,43257237 0,44087372 ! antigen processing and presentation GO:0019882 117 78 0,000 0,43257237 0,44068987 ! fertilization GO:0009566 99 78 0,000 0,43257237 0,44050617 ! blood coagulation GO:0007596 151 79 0,000 0,43668417 0,44450809 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,43668417 0,44432296 ! protein oligomerization GO:0051259 149 79 0,000 0,43668417 0,44413797 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,44076628 0,44810321 ! muscle cell differentiation GO:0042692 178 81 0,000 0,44481893 0,45203521 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,44481893 0,45184725 ! protein import into nucleus GO:0006606 174 82 0,000 0,44884232 0,45574471 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,45283666 0,45960946 ! exocytosis GO:0006887 153 83 0,000 0,45283666 0,45941859 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,45283666 0,45922788 ! nuclear import GO:0051170 177 83 0,000 0,45283666 0,45903733 ! digestion GO:0007586 130 84 0,000 0,45680218 0,46286508 ! hemostasis GO:0007599 165 85 0,000 0,46073906 0,46666066 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,46073906 0,46646727 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,46073906 0,46627403 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,46464752 0,47003473 ! regulation of lyase activity GO:0051339 169 86 0,000 0,46464752 0,46984018 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,46852776 0,47356777 ! nucleosome assembly GO:0006334 126 87 0,000 0,46852776 0,47337192 ! cellular respiration GO:0045333 143 88 0,000 0,47237998 0,47706668 ! amine biosynthetic process GO:0009309 146 88 0,000 0,47237998 0,47686955 ! sensory perception of smell GO:0007608 117 88 0,000 0,47237998 0,47667257 ! chromatin assembly GO:0031497 128 88 0,000 0,47237998 0,47647576 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,4762044 0,4801351 ! cellular defense response GO:0006968 123 89 0,000 0,4762044 0,47993702 ! protein localization in nucleus GO:0034504 192 89 0,000 0,4762044 0,47973911 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,48000119 0,48336476 ! response to unfolded protein GO:0006986 139 90 0,000 0,48000119 0,4831656 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,48377058 0,48675927 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,48377058 0,48655888 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,48751274 0,49012083 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,49122788 0,4936527 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,49122788 0,49344972 ! vitamin metabolic process GO:0006766 153 93 0,000 0,49122788 0,4932469 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,4949162 0,49674621 ! sterol metabolic process GO:0016125 166 94 0,000 0,4949162 0,49654221 ! nucleosome organization GO:0034728 143 95 0,000 0,49857788 0,50001057 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,49857788 0,4998054 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,49857788 0,49960039 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,49857788 0,49939555 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,49857788 0,49919088 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,5058221 0,50623653 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,50940501 0,50961362 ! mRNA transport GO:0051028 185 100 0,000 0,51649341 0,51649341