pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6700-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of MAP kinase activity GO:0043405 67 66 7,000 3,407E-08 6,28E-05 ! regulation of cell migration GO:0030334 71 71 7,000 6,126E-08 5,645E-05 ! gland development GO:0048732 51 49 6,000 8,191E-08 5,032E-05 ! positive regulation of MAP kinase activity GO:0043406 50 49 6,000 8,191E-08 3,774E-05 ! regulation of locomotion GO:0040012 79 79 7,000 1,432E-07 5,278E-05 ! regulation of cell motion GO:0051270 79 79 7,000 1,432E-07 4,398E-05 ! positive regulation of transferase activity GO:0051347 91 88 7,000 3,343E-07 8,8E-05 GO:0033674|positive regulation of kinase activity, ! defense response to virus GO:0051607 9 9 3,000 4,149E-07 9,559E-05 ! regulation of membrane potential GO:0042391 46 46 5,000 1,295E-06 2,651E-04 ! protein amino acid autophosphorylation GO:0046777 28 28 4,000 2,113E-06 3,894E-04 ! vasculogenesis GO:0001570 13 13 3,000 2,3E-06 3,854E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 3,000 2,3E-06 3,533E-04 ! response to hypoxia GO:0001666 53 53 5,000 3,042E-06 4,313E-04 ! response to oxygen levels GO:0070482 55 54 5,000 3,402E-06 4,479E-04 ! positive regulation of protein kinase activity GO:0045860 89 86 6,000 4,101E-06 5,039E-04 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 6,000 4,101E-06 4,724E-04 ! peptidyl-amino acid modification GO:0018193 61 59 5,000 5,76E-06 6,244E-04 ! blood vessel development GO:0001568 95 94 6,000 7,446E-06 7,624E-04 ! positive regulation of cell migration GO:0030335 36 36 4,000 7,728E-06 7,497E-04 ! vasculature development GO:0001944 97 96 6,000 8,567E-06 7,894E-04 ! peptidyl-serine phosphorylation GO:0018105 6 6 2,000 8,992E-06 7,892E-04 ! thymus development GO:0048538 6 6 2,000 8,992E-06 7,533E-04 ! positive regulation of cell motion GO:0051272 39 39 4,000 1,159E-05 9,291E-04 ! negative regulation of bone remodeling GO:0046851 8 8 2,000 2,49E-05 1,912E-03 ! T cell selection GO:0045058 8 8 2,000 2,49E-05 1,836E-03 ! sex determination GO:0007530 8 8 2,000 2,49E-05 1,765E-03 ! peptidyl-serine modification GO:0018209 8 8 2,000 2,49E-05 1,7E-03 ! MAPKKK cascade GO:0000165 82 81 5,000 3,636E-05 2,393E-03 ! response to ethanol GO:0045471 9 9 2,000 3,714E-05 2,36E-03 ! T cell differentiation in the thymus GO:0033077 9 9 2,000 3,714E-05 2,282E-03 ! negative regulation of tissue remodeling GO:0034104 9 9 2,000 3,714E-05 2,208E-03 ! blood vessel morphogenesis GO:0048514 84 83 5,000 4,178E-05 2,406E-03 ! negative regulation of cell migration GO:0030336 26 26 3,000 4,459E-05 2,49E-03 ! gland morphogenesis GO:0022612 10 10 2,000 5,276E-05 2,86E-03 ! negative regulation of homeostatic process GO:0032845 10 10 2,000 5,276E-05 2,778E-03 ! reproductive developmental process GO:0003006 56 56 4,000 6,953E-05 3,56E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 7,215E-05 3,594E-03 ! membrane depolarization GO:0051899 11 11 2,000 7,215E-05 3,499E-03 ! response to temperature stimulus GO:0009266 30 30 3,000 7,986E-05 3,774E-03 ! negative regulation of cell motion GO:0051271 31 31 3,000 9,116E-05 4,2E-03 ! mitochondrial membrane organization GO:0007006 13 13 2,000 1,237E-04 5,559E-03 ! regulation of angiogenesis GO:0045765 35 34 3,000 1,32E-04 5,794E-03 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 1,565E-04 6,709E-03 ! response to retinoic acid GO:0032526 14 14 2,000 1,565E-04 6,556E-03 GO:0033189|response to vitamin A, ! response to radiation GO:0009314 70 68 4,000 1,767E-04 7,237E-03 ! negative regulation of protein kinase activity GO:0006469 37 37 3,000 1,848E-04 7,403E-03 ! lung development GO:0030324 38 37 3,000 1,848E-04 7,246E-03 ! response to vitamin GO:0033273 15 15 2,000 1,946E-04 7,471E-03 ! negative regulation of kinase activity GO:0033673 38 38 3,000 2,053E-04 7,723E-03 ! cell-matrix adhesion GO:0007160 39 38 3,000 2,053E-04 7,568E-03 ! urogenital system development GO:0001655 38 38 3,000 2,053E-04 7,42E-03 ! regulation of homeostatic process GO:0032844 38 38 3,000 2,053E-04 7,277E-03 ! negative regulation of signal transduction GO:0009968 71 71 4,000 2,168E-04 7,539E-03 ! activation of MAPK activity GO:0000187 39 39 3,000 2,275E-04 7,763E-03 ! respiratory tube development GO:0030323 40 39 3,000 2,275E-04 7,622E-03 ! regulation of MAPKKK cascade GO:0043408 41 39 3,000 2,275E-04 7,486E-03 ! respiratory system development GO:0060541 40 39 3,000 2,275E-04 7,355E-03 ! lymphocyte proliferation GO:0046651 16 16 2,000 2,381E-04 7,567E-03 ! negative regulation of transferase activity GO:0051348 40 40 3,000 2,513E-04 7,849E-03 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 2,000 2,876E-04 8,833E-03 ! tissue remodeling GO:0048771 17 17 2,000 2,876E-04 8,689E-03 ! pigmentation GO:0043473 17 17 2,000 2,876E-04 8,548E-03 ! negative regulation of cell communication GO:0010648 76 76 4,000 2,986E-04 8,736E-03 ! cell-substrate adhesion GO:0031589 43 42 3,000 3,042E-04 8,76E-03 ! reproductive structure development GO:0048608 43 43 3,000 3,335E-04 9,455E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 2,000 3,432E-04 9,583E-03 ! mononuclear cell proliferation GO:0032943 18 18 2,000 3,432E-04 9,44E-03 GO:0070661|leukocyte proliferation, ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 2,000 3,432E-04 9,301E-03 ! tube development GO:0035295 83 81 4,000 4,021E-04 0,01073884 ! regulation of endothelial cell proliferation GO:0001936 19 19 2,000 4,053E-04 0,01067007 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 2,000 4,053E-04 0,01051978 ! sex differentiation GO:0007548 47 47 3,000 4,709E-04 0,01205347 ! peptidyl-tyrosine modification GO:0018212 21 20 2,000 4,741E-04 0,01197047 ! calcium ion transport GO:0006816 48 48 3,000 5,107E-04 0,01271985 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 2,000 5,501E-04 0,01351787 ! mammary gland development GO:0030879 23 21 2,000 5,501E-04 0,01334 ! leukocyte differentiation GO:0002521 50 49 3,000 5,529E-04 0,01323389 ! ossification GO:0001503 50 49 3,000 5,529E-04 0,01306422 GO:0060348|bone development, ! divalent metal ion transport GO:0070838 49 49 3,000 5,529E-04 0,01289885 ! skeletal muscle tissue development GO:0007519 50 49 3,000 5,529E-04 0,01273762 GO:0060538|skeletal muscle organ development, ! response to nutrient GO:0007584 49 49 3,000 5,529E-04 0,01258036 ! heart development GO:0007507 90 87 4,000 5,595E-04 0,01257612 ! positive regulation of glucose metabolic process GO:0010907 5 5 1,000 5,956E-04 0,01322584 ! prostate gland development GO:0030850 5 5 1,000 5,956E-04 0,01306839 ! metencephalon development GO:0022037 5 5 1,000 5,956E-04 0,01291464 ! positive regulation of B cell proliferation GO:0030890 5 5 1,000 5,956E-04 0,01276447 ! filopodium assembly GO:0046847 7 5 1,000 5,956E-04 0,01261775 GO:0030035|microspike assembly, ! mRNA stabilization GO:0048255 5 5 1,000 5,956E-04 0,01247437 GO:0043489|RNA stabilization, ! memory GO:0007613 5 5 1,000 5,956E-04 0,01233421 ! thymic T cell selection GO:0045061 5 5 1,000 5,956E-04 0,01219716 ! pituitary gland development GO:0021983 5 5 1,000 5,956E-04 0,01206313 ! indolalkylamine metabolic process GO:0006586 5 5 1,000 5,956E-04 0,011932 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! vesicle fusion GO:0006906 5 5 1,000 5,956E-04 0,0118037 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 5,956E-04 0,01167813 ! fear response GO:0042596 5 5 1,000 5,956E-04 0,0115552 ! protein heterooligomerization GO:0051291 5 5 1,000 5,956E-04 0,01143484 ! response to UV-B GO:0010224 5 5 1,000 5,956E-04 0,01131695 ! response to amine stimulus GO:0014075 5 5 1,000 5,956E-04 0,01120147 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 5,956E-04 0,01108833 ! cellular pigmentation GO:0033059 5 5 1,000 5,956E-04 0,01097744 ! T cell lineage commitment GO:0002360 5 5 1,000 5,956E-04 0,01086876 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 1,000 5,956E-04 0,0107622 GO:0002714|positive regulation of B cell mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 1,000 5,956E-04 0,01065771 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 1,000 5,956E-04 0,01055524 GO:0002820|negative regulation of adaptive immune response, ! peptidyl-lysine modification GO:0018205 5 5 1,000 5,956E-04 0,01045471 ! regulation of isotype switching GO:0045191 5 5 1,000 5,956E-04 0,01035608 ! oocyte differentiation GO:0009994 5 5 1,000 5,956E-04 0,01025929 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 5,956E-04 0,0101643 ! spleen development GO:0048536 5 5 1,000 5,956E-04 0,01007105 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 5,956E-04 9,979E-03 ! B cell receptor signaling pathway GO:0050853 5 5 1,000 5,956E-04 9,89E-03 ! response to nicotine GO:0035094 5 5 1,000 5,956E-04 9,801E-03 ! nucleus localization GO:0051647 5 5 1,000 5,956E-04 9,715E-03 ! positive regulation of DNA metabolic process GO:0051054 23 22 2,000 6,334E-04 0,01024054 ! male sex differentiation GO:0046661 22 22 2,000 6,334E-04 0,01015149 ! response to light stimulus GO:0009416 53 52 3,000 6,943E-04 0,01103092 ! endocrine system development GO:0035270 23 23 2,000 7,244E-04 0,01141115 ! positive regulation of growth GO:0045927 23 23 2,000 7,244E-04 0,01131445 ! cell projection assembly GO:0030031 25 23 2,000 7,244E-04 0,01121937 ! response to virus GO:0009615 54 54 3,000 8,017E-04 0,01231281 ! negative regulation of multicellular organismal process GO:0051241 55 54 3,000 8,017E-04 0,01221106 ! mitochondrial transport GO:0006839 24 24 2,000 8,233E-04 0,01243764 ! T cell differentiation GO:0030217 24 24 2,000 8,233E-04 0,01233652 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 8,889E-04 0,01321234 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 8,889E-04 0,01310664 ! regulation of S phase GO:0033261 6 6 1,000 8,889E-04 0,01300262 ! regulation of B cell proliferation GO:0030888 6 6 1,000 8,889E-04 0,01290024 ! regulation of lipid kinase activity GO:0043550 6 6 1,000 8,889E-04 0,01279946 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 1,000 8,889E-04 0,01270024 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 8,889E-04 0,01260254 GO:0050927|positive regulation of positive chemotaxis, ! pathogenesis GO:0009405 6 6 1,000 8,889E-04 0,01250634 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 1,000 8,889E-04 0,01241159 ! L-serine metabolic process GO:0006563 6 6 1,000 8,889E-04 0,01231827 ! ER overload response GO:0006983 6 6 1,000 8,889E-04 0,01222635 ! focal adhesion formation GO:0048041 7 6 1,000 8,889E-04 0,01213578 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 8,889E-04 0,01204655 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 8,889E-04 0,01195862 ! negative regulation of ossification GO:0030279 6 6 1,000 8,889E-04 0,01187196 ! regulation of bone resorption GO:0045124 6 6 1,000 8,889E-04 0,01178655 ! positive regulation of T cell mediated immunity GO:0002711 6 6 1,000 8,889E-04 0,01170236 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 8,889E-04 0,01161936 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 8,889E-04 0,01153754 ! diencephalon development GO:0021536 6 6 1,000 8,889E-04 0,01145686 ! serine family amino acid biosynthetic process GO:0009070 6 6 1,000 8,889E-04 0,01137729 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 1,000 8,889E-04 0,01129883 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! regulation of embryonic development GO:0045995 6 6 1,000 8,889E-04 0,01122144 ! negative regulation of immune effector process GO:0002698 6 6 1,000 8,889E-04 0,01114511 ! localization within membrane GO:0051668 6 6 1,000 8,889E-04 0,0110698 ! regulation of T cell proliferation GO:0042129 25 25 2,000 9,304E-04 0,01150853 ! negative regulation of immune system process GO:0002683 25 25 2,000 9,304E-04 0,01143181 ! anti-apoptosis GO:0006916 100 99 4,000 1,009E-03 0,01231212 ! regulation of T cell differentiation GO:0045580 26 26 2,000 1,046E-03 0,01268236 ! synapse organization GO:0050808 26 26 2,000 1,046E-03 0,01259946 ! hemopoiesis GO:0030097 104 100 4,000 1,056E-03 0,01263261 ! immune effector process GO:0002252 59 59 3,000 1,121E-03 0,01332681 ! positive regulation of cellular catabolic process GO:0031331 7 7 1,000 1,238E-03 0,01462902 ! hair follicle morphogenesis GO:0031069 7 7 1,000 1,238E-03 0,01453584 ! visual behavior GO:0007632 7 7 1,000 1,238E-03 0,01444384 GO:0008542|visual learning, ! startle response GO:0001964 7 7 1,000 1,238E-03 0,014353 ! digestive system development GO:0055123 7 7 1,000 1,238E-03 0,01426329 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 1,238E-03 0,0141747 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 1,238E-03 0,0140872 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 1,000 1,238E-03 0,01400078 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 1,238E-03 0,0139154 ! axon cargo transport GO:0008088 7 7 1,000 1,238E-03 0,01383107 ! response to gamma radiation GO:0010332 8 7 1,000 1,238E-03 0,01374775 ! dopamine metabolic process GO:0042417 7 7 1,000 1,238E-03 0,01366543 ! regulation of mRNA stability GO:0043488 7 7 1,000 1,238E-03 0,01358409 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 1,000 1,238E-03 0,01350371 ! positive regulation of protein polymerization GO:0032273 7 7 1,000 1,238E-03 0,01342427 ! T cell receptor signaling pathway GO:0050852 7 7 1,000 1,238E-03 0,01334577 ! negative regulation of T cell activation GO:0050868 7 7 1,000 1,238E-03 0,01326818 ! response to cold GO:0009409 7 7 1,000 1,238E-03 0,01319148 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 3,000 1,27E-03 0,01345541 ! stress-activated protein kinase signaling pathway GO:0031098 28 28 2,000 1,303E-03 0,01372656 GO:0007254|JNK cascade, ! regulation of mast cell proliferation GO:0070666 28 28 2,000 1,303E-03 0,01364856 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 3,000 1,35E-03 0,01405797 ! regulation of epithelial cell proliferation GO:0050678 29 29 2,000 1,446E-03 0,01496918 ! regulation of lymphocyte proliferation GO:0050670 29 29 2,000 1,446E-03 0,01488555 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! response to UV GO:0009411 29 29 2,000 1,446E-03 0,01480286 ! vesicle organization GO:0016050 30 30 2,000 1,598E-03 0,0162664 ! anion transport GO:0006820 65 65 3,000 1,61E-03 0,0163074 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 1,643E-03 0,01654393 ! positive regulation of cell killing GO:0031343 8 8 1,000 1,643E-03 0,01645402 ! lipid localization GO:0010876 8 8 1,000 1,643E-03 0,01636508 GO:0019915|lipid storage, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 1,000 1,643E-03 0,01627709 ! organelle fusion GO:0048284 8 8 1,000 1,643E-03 0,01619005 ! Golgi organization GO:0007030 8 8 1,000 1,643E-03 0,01610393 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 1,643E-03 0,01601872 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 1,643E-03 0,01593442 ! plasma membrane fusion GO:0045026 8 8 1,000 1,643E-03 0,01585099 ! alpha-beta T cell activation GO:0046631 8 8 1,000 1,643E-03 0,01576843 ! regulation of vasodilation GO:0042312 8 8 1,000 1,643E-03 0,01568673 ! regulation of T cell mediated immunity GO:0002709 8 8 1,000 1,643E-03 0,01560587 ! regulation of fatty acid metabolic process GO:0019217 8 8 1,000 1,643E-03 0,01552584 ! sensory perception of pain GO:0019233 8 8 1,000 1,643E-03 0,01544663 ! T cell homeostasis GO:0043029 8 8 1,000 1,643E-03 0,01536822 ! positive regulation of leukocyte migration GO:0002687 8 8 1,000 1,643E-03 0,0152906 ! regulation of immunoglobulin production GO:0002637 8 8 1,000 1,643E-03 0,01521376 ! regulation of RNA stability GO:0043487 8 8 1,000 1,643E-03 0,01513769 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 1,000 1,643E-03 0,01506238 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 1,643E-03 0,01498782 ! negative regulation of protein metabolic process GO:0051248 66 66 3,000 1,704E-03 0,01547389 ! membrane fusion GO:0006944 31 31 2,000 1,759E-03 0,01589054 ! striated muscle tissue development GO:0014706 69 67 3,000 1,802E-03 0,01620181 ! Ras protein signal transduction GO:0007265 69 67 3,000 1,802E-03 0,01612316 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 2,000 1,93E-03 0,01718487 ! regulation of lymphocyte differentiation GO:0045619 32 32 2,000 1,93E-03 0,01710225 ! response to nutrient levels GO:0031667 69 69 3,000 2,009E-03 0,0177179 ! positive regulation of cell projection organization GO:0031346 9 9 1,000 2,101E-03 0,01844282 ! positive regulation of protein complex assembly GO:0031334 9 9 1,000 2,101E-03 0,01835542 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 2,101E-03 0,01826883 ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 1,000 2,101E-03 0,01818306 ! regulation of postsynaptic membrane potential GO:0060078 9 9 1,000 2,101E-03 0,0180981 ! response to alkaloid GO:0043279 10 9 1,000 2,101E-03 0,01801392 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 1,000 2,101E-03 0,01793052 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 1,000 2,101E-03 0,01784789 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 2,101E-03 0,01776602 ! pigmentation during development GO:0048066 9 9 1,000 2,101E-03 0,0176849 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 2,101E-03 0,01760451 GO:0060675|ureteric bud morphogenesis, ! histone acetylation GO:0016573 9 9 1,000 2,101E-03 0,01752485 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 1,000 2,101E-03 0,01744591 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 1,000 2,101E-03 0,01736768 GO:0002712|regulation of B cell mediated immunity, ! regulation of leukocyte migration GO:0002685 9 9 1,000 2,101E-03 0,01729015 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 1,000 2,101E-03 0,0172133 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 2,101E-03 0,01713714 ! regulation of protein complex assembly GO:0043254 33 33 2,000 2,111E-03 0,01714272 ! regulation of neuron differentiation GO:0045664 34 33 2,000 2,111E-03 0,01706753 ! muscle tissue development GO:0060537 72 70 3,000 2,119E-03 0,01705163 ! calcium ion homeostasis GO:0055074 71 71 3,000 2,232E-03 0,01788737 GO:0006874|cellular calcium ion homeostasis, ! regulation of bone remodeling GO:0046850 34 34 2,000 2,303E-03 0,01837418 ! ear development GO:0043583 34 34 2,000 2,303E-03 0,01829498 ! regulation of lipid metabolic process GO:0019216 34 34 2,000 2,303E-03 0,01821646 ! response to peptide hormone stimulus GO:0043434 36 34 2,000 2,303E-03 0,01813861 ! response to extracellular stimulus GO:0009991 72 72 3,000 2,35E-03 0,01842975 ! mesoderm development GO:0007498 35 35 2,000 2,505E-03 0,01956247 ! regulation of tissue remodeling GO:0034103 35 35 2,000 2,505E-03 0,01947993 ! regulation of glucose metabolic process GO:0010906 10 10 1,000 2,614E-03 0,0202392 ! regulation of cell killing GO:0031341 10 10 1,000 2,614E-03 0,02015452 ! calcium-independent cell-cell adhesion GO:0016338 10 10 1,000 2,614E-03 0,02007054 ! auditory receptor cell differentiation GO:0042491 10 10 1,000 2,614E-03 0,01998726 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 2,614E-03 0,01990467 ! inactivation of MAPK activity GO:0000188 10 10 1,000 2,614E-03 0,01982276 ! regulation of survival gene product expression GO:0045884 10 10 1,000 2,614E-03 0,01974152 ! epidermis morphogenesis GO:0048730 10 10 1,000 2,614E-03 0,01966094 ! cell-substrate junction assembly GO:0007044 11 10 1,000 2,614E-03 0,01958102 ! cell structure disassembly during apoptosis GO:0006921 10 10 1,000 2,614E-03 0,01950174 ! neuromuscular junction development GO:0007528 10 10 1,000 2,614E-03 0,0194231 ! regulation of protein binding GO:0043393 11 10 1,000 2,614E-03 0,0193451 ! negative regulation of immune response GO:0050777 10 10 1,000 2,614E-03 0,01926772 ! regulation of B cell differentiation GO:0045577 10 10 1,000 2,614E-03 0,01919096 ! negative regulation of neuron differentiation GO:0045665 10 10 1,000 2,614E-03 0,0191148 ! lymphocyte homeostasis GO:0002260 10 10 1,000 2,614E-03 0,01903925 ! gut development GO:0048565 10 10 1,000 2,614E-03 0,01896429 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 1,000 2,614E-03 0,01888992 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 2,000 2,718E-03 0,01956513 ! integrin-mediated signaling pathway GO:0007229 36 36 2,000 2,718E-03 0,019489 ! gonad development GO:0008406 36 36 2,000 2,718E-03 0,01941347 ! response to drug GO:0042493 37 37 2,000 2,941E-03 0,02092883 ! cellular metal ion homeostasis GO:0006875 77 77 3,000 3,003E-03 0,02128762 ! regulation of protein modification process GO:0031399 79 78 3,000 3,147E-03 0,02222361 ! metal ion homeostasis GO:0055065 78 78 3,000 3,147E-03 0,02213879 ! myeloid leukocyte differentiation GO:0002573 12 11 1,000 3,178E-03 0,02227304 ! microtubule-based transport GO:0010970 11 11 1,000 3,178E-03 0,02218868 ! protein amino acid acetylation GO:0006473 11 11 1,000 3,178E-03 0,02210495 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 1,000 3,178E-03 0,02202184 GO:0032388|positive regulation of intracellular transport, ! T cell proliferation GO:0042098 11 11 1,000 3,178E-03 0,02193937 ! negative regulation of endothelial cell proliferation GO:0001937 11 11 1,000 3,178E-03 0,0218575 ! regulation of viral genome replication GO:0045069 11 11 1,000 3,178E-03 0,02177625 ! apoptotic nuclear changes GO:0030262 11 11 1,000 3,178E-03 0,02169559 ! regulation of cellular ketone metabolic process GO:0010565 11 11 1,000 3,178E-03 0,02161554 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 1,000 3,178E-03 0,02153607 ! interaction with host GO:0051701 11 11 1,000 3,178E-03 0,02145718 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 3,178E-03 0,02137887 ! oogenesis GO:0048477 11 11 1,000 3,178E-03 0,02130113 ! negative regulation of angiogenesis GO:0016525 11 11 1,000 3,178E-03 0,02122395 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 1,000 3,178E-03 0,02114733 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 1,000 3,178E-03 0,02107126 GO:0006109|regulation of carbohydrate metabolic process, ! hindbrain development GO:0030902 11 11 1,000 3,178E-03 0,02099574 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 3,178E-03 0,02092075 ! lymphocyte differentiation GO:0030098 39 39 2,000 3,421E-03 0,02243966 ! protein oligomerization GO:0051259 39 39 2,000 3,421E-03 0,02236009 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 1,000 3,795E-03 0,02471417 ! heterophilic cell adhesion GO:0007157 12 12 1,000 3,795E-03 0,02462715 ! glutamate signaling pathway GO:0007215 12 12 1,000 3,795E-03 0,02454074 ! osteoblast differentiation GO:0001649 12 12 1,000 3,795E-03 0,02445494 ! male gonad development GO:0008584 12 12 1,000 3,795E-03 0,02436973 ! regulation of alpha-beta T cell activation GO:0046634 12 12 1,000 3,795E-03 0,02428511 ! renal system process GO:0003014 12 12 1,000 3,795E-03 0,02420108 ! cell fate determination GO:0001709 12 12 1,000 3,795E-03 0,02411763 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 3,795E-03 0,02403475 ! somitogenesis GO:0001756 13 12 1,000 3,795E-03 0,02395244 ! positive regulation of adaptive immune response GO:0002821 12 12 1,000 3,795E-03 0,02387069 ! synaptogenesis GO:0007416 12 12 1,000 3,795E-03 0,02378949 ! negative regulation of translation GO:0017148 12 12 1,000 3,795E-03 0,02370885 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 1,000 3,795E-03 0,02362876 ! development of primary sexual characteristics GO:0045137 42 42 2,000 4,227E-03 0,02623101 ! positive regulation of DNA replication GO:0045740 14 13 1,000 4,462E-03 0,02759841 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 4,462E-03 0,02750611 ! phenol metabolic process GO:0018958 13 13 1,000 4,462E-03 0,02741442 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! regeneration GO:0031099 13 13 1,000 4,462E-03 0,02732335 ! post-embryonic development GO:0009791 14 13 1,000 4,462E-03 0,02723287 ! negative regulation of protein modification process GO:0031400 13 13 1,000 4,462E-03 0,02714299 ! regulation of DNA recombination GO:0000018 13 13 1,000 4,462E-03 0,02705371 ! response to corticosteroid stimulus GO:0031960 13 13 1,000 4,462E-03 0,02696501 GO:0051384|response to glucocorticoid stimulus, ! negative regulation of protein catabolic process GO:0042177 13 13 1,000 4,462E-03 0,02687689 ! ureteric bud development GO:0001657 13 13 1,000 4,462E-03 0,02678934 ! cell aging GO:0007569 13 13 1,000 4,462E-03 0,02670236 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 4,462E-03 0,02661595 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 4,462E-03 0,02653009 ! coenzyme catabolic process GO:0009109 13 13 1,000 4,462E-03 0,02644478 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 1,000 4,462E-03 0,02636002 ! regulation of viral reproduction GO:0050792 13 13 1,000 4,462E-03 0,02627581 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 1,000 4,462E-03 0,02619212 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 1,000 4,462E-03 0,02610897 ! positive regulation of locomotion GO:0040017 13 13 1,000 4,462E-03 0,02602635 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! immunoglobulin production GO:0002377 13 13 1,000 4,462E-03 0,02594425 GO:0002440|production of molecular mediator of immune response, ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 4,462E-03 0,02586266 ! regulation of cell-substrate adhesion GO:0010810 14 13 1,000 4,462E-03 0,02578159 GO:0001952|regulation of cell-matrix adhesion, ! response to cytokine stimulus GO:0034097 13 13 1,000 4,462E-03 0,02570102 ! activation of JUN kinase activity GO:0007257 13 13 1,000 4,462E-03 0,02562096 ! tissue homeostasis GO:0001894 13 13 1,000 4,462E-03 0,02554139 GO:0048871|multicellular organismal homeostasis, ! inner ear receptor cell differentiation GO:0060113 13 13 1,000 4,462E-03 0,02546231 ! protein tetramerization GO:0051262 13 13 1,000 4,462E-03 0,02538373 ! mitochondrion organization GO:0007005 44 43 2,000 4,519E-03 0,02562711 ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 3,000 5,056E-03 0,02858283 ! Wnt receptor signaling pathway GO:0016055 46 45 2,000 5,139E-03 0,02896515 ! neuron fate commitment GO:0048663 14 14 1,000 5,18E-03 0,02910661 ! acetyl-CoA metabolic process GO:0006084 14 14 1,000 5,18E-03 0,02901814 ! protein amino acid acylation GO:0043543 14 14 1,000 5,18E-03 0,02893021 ! vesicle docking GO:0048278 14 14 1,000 5,18E-03 0,02884281 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 1,000 5,18E-03 0,02875593 ! mechanoreceptor differentiation GO:0042490 14 14 1,000 5,18E-03 0,02866958 ! hair cycle GO:0042633 14 14 1,000 5,18E-03 0,02858374 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 1,000 5,18E-03 0,02849841 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! multicellular organismal response to stress GO:0033555 14 14 1,000 5,18E-03 0,0284136 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 1,000 5,18E-03 0,02832928 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of behavior GO:0050795 14 14 1,000 5,18E-03 0,02824547 ! response to organic cyclic substance GO:0014070 15 14 1,000 5,18E-03 0,02816215 ! regulation of vasoconstriction GO:0019229 14 14 1,000 5,18E-03 0,02807932 ! regulation of blood coagulation GO:0030193 15 14 1,000 5,18E-03 0,02799698 ! negative regulation of cell cycle GO:0045786 92 91 3,000 5,471E-03 0,02948199 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 3,000 5,471E-03 0,02939604 ! regulation of catabolic process GO:0009894 48 47 2,000 5,808E-03 0,03111795 ! negative regulation of protein complex assembly GO:0031333 15 15 1,000 5,947E-03 0,03176975 ! detection of stimulus involved in sensory perception GO:0050906 16 15 1,000 5,947E-03 0,03167793 ! insulin receptor signaling pathway GO:0008286 17 15 1,000 5,947E-03 0,03158664 ! ovarian follicle development GO:0001541 15 15 1,000 5,947E-03 0,03149587 ! regulation of smooth muscle contraction GO:0006940 15 15 1,000 5,947E-03 0,03140563 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 5,947E-03 0,0313159 ! response to ionizing radiation GO:0010212 16 15 1,000 5,947E-03 0,03122668 ! regulation of production of molecular mediator of immune response GO:0002700 15 15 1,000 5,947E-03 0,03113797 ! leukocyte homeostasis GO:0001776 15 15 1,000 5,947E-03 0,03104976 ! positive regulation of B cell activation GO:0050871 15 15 1,000 5,947E-03 0,03096205 ! negative regulation of cell activation GO:0050866 15 15 1,000 5,947E-03 0,03087483 ! protein homooligomerization GO:0051260 15 15 1,000 5,947E-03 0,0307881 ! positive regulation of immune effector process GO:0002699 15 15 1,000 5,947E-03 0,03070186 ! regulation of cell growth GO:0001558 97 96 3,000 6,607E-03 0,03401268 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 6,763E-03 0,03471771 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of synaptic plasticity GO:0048167 16 16 1,000 6,763E-03 0,03462127 ! learning GO:0007612 16 16 1,000 6,763E-03 0,03452537 ! positive regulation of cytoskeleton organization GO:0051495 16 16 1,000 6,763E-03 0,03443 ! segmentation GO:0035282 17 16 1,000 6,763E-03 0,03433515 ! triglyceride metabolic process GO:0006641 16 16 1,000 6,763E-03 0,03424082 ! positive regulation of cell development GO:0010720 16 16 1,000 6,763E-03 0,03414701 ! positive regulation of MAPKKK cascade GO:0043410 17 16 1,000 6,763E-03 0,03405371 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 1,000 6,763E-03 0,03396092 ! cofactor catabolic process GO:0051187 16 16 1,000 6,763E-03 0,03386864 ! serine family amino acid metabolic process GO:0009069 16 16 1,000 6,763E-03 0,03377685 ! positive regulation of catabolic process GO:0009896 16 16 1,000 6,763E-03 0,03368556 ! regulation of JUN kinase activity GO:0043506 17 16 1,000 6,763E-03 0,03359477 GO:0043507|positive regulation of JUN kinase activity, ! regulation of coagulation GO:0050818 17 16 1,000 6,763E-03 0,03350446 ! regulation of DNA metabolic process GO:0051052 51 50 2,000 6,906E-03 0,034121 ! T cell activation GO:0042110 51 50 2,000 6,906E-03 0,03402977 ! regulation of neurogenesis GO:0050767 51 50 2,000 6,906E-03 0,03393902 ! anterior/posterior pattern formation GO:0009952 51 50 2,000 6,906E-03 0,03384876 ! posttranscriptional regulation of gene expression GO:0010608 98 98 3,000 7,102E-03 0,03471916 ! interphase of mitotic cell cycle GO:0051329 52 51 2,000 7,297E-03 0,03557758 GO:0051325|interphase, ! muscle organ development GO:0007517 102 100 3,000 7,621E-03 0,03706066 ! response to other organism GO:0051707 101 100 3,000 7,621E-03 0,03696313 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 7,626E-03 0,03688927 ! myelination GO:0042552 17 17 1,000 7,626E-03 0,0367927 ! leukocyte adhesion GO:0007159 17 17 1,000 7,626E-03 0,03669664 ! cell junction assembly GO:0034329 18 17 1,000 7,626E-03 0,03660107 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 7,626E-03 0,03650601 ! response to toxin GO:0009636 18 17 1,000 7,626E-03 0,03641143 ! immune response-activating signal transduction GO:0002757 17 17 1,000 7,626E-03 0,03631735 GO:0002764|immune response-regulating signal transduction, ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 7,626E-03 0,03622374 ! liver development GO:0001889 17 17 1,000 7,626E-03 0,03613062 ! cell fate commitment GO:0045165 52 52 2,000 7,701E-03 0,03639321 ! regulation of T cell activation GO:0050863 53 53 2,000 8,118E-03 0,03826698 ! regulation of cell projection organization GO:0031344 19 18 1,000 8,536E-03 0,0401342 ! regulation of cellular catabolic process GO:0031329 18 18 1,000 8,536E-03 0,04003207 ! membrane docking GO:0022406 18 18 1,000 8,536E-03 0,03993047 ! cholesterol homeostasis GO:0042632 18 18 1,000 8,536E-03 0,03982938 GO:0055092|sterol homeostasis, ! neutral lipid metabolic process GO:0006638 18 18 1,000 8,536E-03 0,0397288 GO:0006639|acylglycerol metabolic process, ! negative regulation of MAP kinase activity GO:0043407 18 18 1,000 8,536E-03 0,03962873 ! B cell differentiation GO:0030183 18 18 1,000 8,536E-03 0,03952916 ! ensheathment of neurons GO:0007272 18 18 1,000 8,536E-03 0,03943009 GO:0008366|axon ensheathment, ! regulation of microtubule-based process GO:0032886 18 18 1,000 8,536E-03 0,03933151 ! negative regulation of catabolic process GO:0009895 18 18 1,000 8,536E-03 0,03923343 ! protein amino acid dephosphorylation GO:0006470 55 54 2,000 8,549E-03 0,03919308 ! regulation of cell adhesion GO:0030155 56 55 2,000 8,993E-03 0,04112456 ! extracellular structure organization GO:0043062 56 56 2,000 9,449E-03 0,04310716 ! regulation of nervous system development GO:0051960 57 56 2,000 9,449E-03 0,04300072 ! regulation of JAK-STAT cascade GO:0046425 19 19 1,000 9,493E-03 0,04309268 ! positive regulation of T cell proliferation GO:0042102 19 19 1,000 9,493E-03 0,0429868 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 9,493E-03 0,04288144 ! metanephros development GO:0001656 19 19 1,000 9,493E-03 0,0427766 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 1,000 9,493E-03 0,04267226 ! positive regulation of T cell differentiation GO:0045582 19 19 1,000 9,493E-03 0,04256844 ! peripheral nervous system development GO:0007422 19 19 1,000 9,493E-03 0,04246512 ! regulation of protein stability GO:0031647 19 19 1,000 9,493E-03 0,0423623 ! regulation of cell shape GO:0008360 21 19 1,000 9,493E-03 0,04225997 ! response to heat GO:0009408 19 19 1,000 9,493E-03 0,04215814 ! regulation of binding GO:0051098 60 57 2,000 9,92E-03 0,04394723 ! regulation of protein localization GO:0032880 58 57 2,000 9,92E-03 0,04384184 ! regulation of muscle development GO:0048634 21 20 1,000 0,01049511 0,04627391 ! establishment or maintenance of cell polarity GO:0007163 21 20 1,000 0,01049511 0,04616347 ! organic ether metabolic process GO:0018904 20 20 1,000 0,01049511 0,04605356 GO:0006662|glycerol ether metabolic process, ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 1,000 0,01049511 0,04594416 ! nucleus organization GO:0006997 20 20 1,000 0,01049511 0,04583529 ! chromatin remodeling GO:0006338 20 20 1,000 0,01049511 0,04572693 ! detection of abiotic stimulus GO:0009582 21 20 1,000 0,01049511 0,04561909 ! female gamete generation GO:0007292 20 20 1,000 0,01049511 0,04551175 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 0,01049511 0,04540491 ! regulation of B cell activation GO:0050864 20 20 1,000 0,01049511 0,04529858 ! regulation of cell development GO:0060284 60 59 2,000 0,01090076 0,04693949 ! dephosphorylation GO:0016311 60 59 2,000 0,01090076 0,04683008 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 2,000 0,01141165 0,04891085 ! regulation of leukocyte mediated immunity GO:0002703 21 21 1,000 0,01154196 0,04935458 ! cellular response to insulin stimulus GO:0032869 23 21 1,000 0,01154196 0,04924034 ! Notch signaling pathway GO:0007219 22 21 1,000 0,01154196 0,04912662 ! cholesterol transport GO:0030301 21 21 1,000 0,01154196 0,04901342 GO:0015918|sterol transport, ! regulation of action potential in neuron GO:0019228 21 21 1,000 0,01154196 0,04890075 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 0,01154196 0,04878859 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 1,000 0,01154196 0,04867695 ! axonogenesis GO:0007409 66 62 2,000 0,01247447 0,05248962 ! regulation of cellular component biogenesis GO:0044087 63 62 2,000 0,01247447 0,05237005 ! regulation of lymphocyte activation GO:0051249 62 62 2,000 0,01247447 0,05225103 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 0,01263281 0,05279425 GO:0090047|positive regulation of transcription regulator activity, ! cell junction organization GO:0034330 23 22 1,000 0,01263281 0,05267481 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 1,000 0,01263281 0,0525559 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! ovulation cycle process GO:0022602 22 22 1,000 0,01263281 0,05243753 ! regulation of adaptive immune response GO:0002819 22 22 1,000 0,01263281 0,0523197 ! detection of external stimulus GO:0009581 23 22 1,000 0,01263281 0,05220239 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 1,000 0,01263281 0,0520856 ! aerobic respiration GO:0009060 22 22 1,000 0,01263281 0,05196934 ! regulation of response to external stimulus GO:0032101 65 64 2,000 0,01359242 0,0557925 ! regulation of cytoskeleton organization GO:0051493 66 64 2,000 0,01359242 0,05566852 ! angiogenesis GO:0001525 65 64 2,000 0,01359242 0,05554508 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,01376694 0,05613379 ! response to estrogen stimulus GO:0043627 23 23 1,000 0,01376694 0,05600987 ! female gonad development GO:0008585 23 23 1,000 0,01376694 0,0558865 ! lipid homeostasis GO:0055088 23 23 1,000 0,01376694 0,05576367 ! calcium-mediated signaling GO:0019722 23 23 1,000 0,01376694 0,05564138 ! Rho protein signal transduction GO:0007266 24 23 1,000 0,01376694 0,05551963 ! regulation of JNK cascade GO:0046328 25 23 1,000 0,01376694 0,05539841 ! positive regulation of cellular component organization GO:0051130 65 65 2,000 0,0141722 0,05690492 ! regulation of action potential GO:0001508 24 24 1,000 0,01494363 0,05987199 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 1,000 0,01494363 0,05974211 ! cellular amino acid biosynthetic process GO:0008652 24 24 1,000 0,01494363 0,0596128 ! glucose homeostasis GO:0042593 24 24 1,000 0,01494363 0,05948405 GO:0033500|carbohydrate homeostasis, ! ovulation cycle GO:0042698 24 24 1,000 0,01494363 0,05935585 ! androgen receptor signaling pathway GO:0030521 24 24 1,000 0,01494363 0,0592282 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,01494363 0,0591011 ! glucan metabolic process GO:0044042 25 24 1,000 0,01494363 0,05897455 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 0,01537358 0,06054167 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! negative regulation of cell differentiation GO:0045596 68 67 2,000 0,01537358 0,06041259 ! regulation of cell size GO:0008361 68 68 2,000 0,01599526 0,06272185 ! regulation of gene-specific transcription GO:0032583 25 25 1,000 0,01616217 0,06324179 ! cellular component disassembly GO:0022411 26 25 1,000 0,01616217 0,0631078 ! regulation of intracellular protein transport GO:0033157 25 25 1,000 0,01616217 0,06297438 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,01616217 0,06284153 GO:0046660|female sex differentiation, ! positive regulation of DNA binding GO:0043388 26 25 1,000 0,01616217 0,06270923 ! heart morphogenesis GO:0003007 25 25 1,000 0,01616217 0,06257749 ! regionalization GO:0003002 70 69 2,000 0,01663099 0,06425768 ! regulation of leukocyte activation GO:0002694 69 69 2,000 0,01663099 0,06412325 ! cell part morphogenesis GO:0032990 75 70 2,000 0,01728079 0,06648956 ! growth GO:0040007 70 70 2,000 0,01728079 0,06635104 ! positive regulation of binding GO:0051099 27 26 1,000 0,01742186 0,0667536 ! glycolysis GO:0006096 26 26 1,000 0,01742186 0,06661511 ! germ cell development GO:0007281 27 26 1,000 0,01742186 0,06647719 ! pigment metabolic process GO:0042440 26 26 1,000 0,01742186 0,06633984 ! response to insulin stimulus GO:0032868 28 26 1,000 0,01742186 0,06620305 ! regulation of cell activation GO:0050865 71 71 2,000 0,0179447 0,06804954 ! sensory organ development GO:0007423 72 72 2,000 0,01862273 0,07047575 ! chloride transport GO:0006821 27 27 1,000 0,01872199 0,0707062 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 1,000 0,01872199 0,0705616 ! energy reserve metabolic process GO:0006112 28 27 1,000 0,01872199 0,0704176 ! learning or memory GO:0007611 28 27 1,000 0,01872199 0,07027418 ! mesenchymal cell development GO:0014031 29 27 1,000 0,01872199 0,07013135 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! inner ear development GO:0048839 27 27 1,000 0,01872199 0,06998909 ! cell growth GO:0016049 27 27 1,000 0,01872199 0,06984742 ! neuromuscular process GO:0050905 28 28 1,000 0,02006188 0,07469504 ! regulation of muscle contraction GO:0006937 28 28 1,000 0,02006188 0,07454445 ! histone modification GO:0016570 28 28 1,000 0,02006188 0,07439446 ! developmental growth GO:0048589 28 28 1,000 0,02006188 0,07424507 ! positive regulation of cell cycle GO:0045787 29 29 1,000 0,02144085 0,07918936 ! viral reproductive process GO:0022415 29 29 1,000 0,02144085 0,07903098 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,02144085 0,07887324 ! covalent chromatin modification GO:0016569 29 29 1,000 0,02144085 0,07871612 ! regulation of protein polymerization GO:0032271 29 29 1,000 0,02144085 0,07855963 ! positive regulation of protein transport GO:0051222 29 29 1,000 0,02144085 0,07840375 ! positive regulation of multicellular organismal process GO:0051240 76 76 2,000 0,0214765 0,07837859 ! cell morphogenesis involved in differentiation GO:0000904 82 77 2,000 0,02222542 0,08095148 ! response to reactive oxygen species GO:0000302 31 30 1,000 0,02285823 0,08309216 ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,02285823 0,08292859 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of response to external stimulus GO:0032103 30 30 1,000 0,02285823 0,08276567 ! regulation of ossification GO:0030278 30 30 1,000 0,02285823 0,08260338 ! vascular process in circulatory system GO:0003018 31 30 1,000 0,02285823 0,08244173 ! establishment of organelle localization GO:0051656 31 30 1,000 0,02285823 0,08228071 ! microtubule-based movement GO:0007018 82 78 2,000 0,02298855 0,08258848 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,02431336 0,08717806 ! B cell activation GO:0042113 31 31 1,000 0,02431336 0,08700878 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,02431336 0,08684016 ! aging GO:0007568 32 31 1,000 0,02431336 0,08667219 ! regulation of DNA replication GO:0006275 32 31 1,000 0,02431336 0,08650487 ! regulation of intracellular transport GO:0032386 31 31 1,000 0,02431336 0,08633819 ! neuron projection development GO:0031175 85 80 2,000 0,02455743 0,0870372 ! lymphocyte activation GO:0046649 82 81 2,000 0,02536319 0,08972044 ! negative regulation of cell growth GO:0030308 32 32 1,000 0,02580557 0,09111048 ! muscle fiber development GO:0048747 32 32 1,000 0,02580557 0,09093628 ! glucose catabolic process GO:0006007 32 32 1,000 0,02580557 0,09076273 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,02580557 0,09058985 ! cell maturation GO:0048469 32 32 1,000 0,02580557 0,09041763 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,02580557 0,09024606 ! nuclear export GO:0051168 32 32 1,000 0,02580557 0,09007514 ! kidney development GO:0001822 32 32 1,000 0,02580557 0,08990486 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,02580557 0,08973523 ! negative regulation of cell size GO:0045792 33 33 1,000 0,02733423 0,0948719 ! regulation of cellular response to stress GO:0080135 35 33 1,000 0,02733423 0,09469357 ! amino acid transport GO:0006865 33 33 1,000 0,02733423 0,09451591 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 1,000 0,02733423 0,09433892 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,02733423 0,09416258 ! regulation of synaptic transmission GO:0050804 33 33 1,000 0,02733423 0,09398691 ! positive regulation of cell differentiation GO:0045597 87 85 2,000 0,02872813 0,09859579 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,02872813 0,09841252 ! regulation of actin filament length GO:0030832 34 34 1,000 0,02889868 0,09881311 ! response to metal ion GO:0010038 34 34 1,000 0,02889868 0,09863012 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 0,02889868 0,09844781 ! regulation of protein catabolic process GO:0042176 35 34 1,000 0,02889868 0,09826617 ! secondary metabolic process GO:0019748 34 34 1,000 0,02889868 0,0980852 ! negative regulation of response to stimulus GO:0048585 34 34 1,000 0,02889868 0,0979049 ! viral reproduction GO:0016032 34 34 1,000 0,02889868 0,09772526 ! detection of stimulus GO:0051606 36 34 1,000 0,02889868 0,09754627 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 1,000 0,03049829 0,10275751 ! regulation of cellular component size GO:0032535 35 35 1,000 0,03049829 0,10257 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,03049829 0,10238316 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,03049829 0,10219701 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 0,03049829 0,10201154 ! inorganic anion transport GO:0015698 35 35 1,000 0,03049829 0,10182673 ! response to steroid hormone stimulus GO:0048545 35 35 1,000 0,03049829 0,1016426 ! regulation of immune effector process GO:0002697 35 35 1,000 0,03049829 0,10145913 ! response to inorganic substance GO:0010035 36 36 1,000 0,03213245 0,10670289 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 0,03213245 0,10651098 GO:0045937|positive regulation of phosphate metabolic process, ! female pregnancy GO:0007565 37 36 1,000 0,03213245 0,10631975 ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,03213245 0,10612922 ! regulation of transmission of nerve impulse GO:0051969 36 36 1,000 0,03213245 0,10593936 ! regulation of lipase activity GO:0060191 36 36 1,000 0,03213245 0,10575018 ! activation of immune response GO:0002253 36 36 1,000 0,03213245 0,10556168 ! brain development GO:0007420 91 90 2,000 0,03325254 0,10904703 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 0,03380052 0,11064718 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! regulation of transcription factor activity GO:0051090 38 37 1,000 0,03380052 0,110451 GO:0090046|regulation of transcription regulator activity, ! negative regulation of growth GO:0045926 37 37 1,000 0,03380052 0,11025551 ! regulation of Rho protein signal transduction GO:0035023 37 37 1,000 0,03380052 0,11006071 ! adaptive immune response GO:0002250 37 37 1,000 0,03380052 0,1098666 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! energy derivation by oxidation of organic compounds GO:0015980 94 92 2,000 0,03516075 0,11408674 ! positive regulation of immune system process GO:0002684 92 92 2,000 0,03516075 0,11388624 ! hexose catabolic process GO:0019320 38 38 1,000 0,0355019 0,11478949 ! axon guidance GO:0007411 39 38 1,000 0,0355019 0,11458845 ! regulation of neurological system process GO:0031644 38 38 1,000 0,0355019 0,11438813 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 0,0355019 0,1141885 ! regulation of response to stress GO:0080134 97 94 2,000 0,03712487 0,11920058 ! pattern specification process GO:0007389 96 94 2,000 0,03712487 0,11899328 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,03723599 0,11914223 ! cytokine-mediated signaling pathway GO:0019221 39 39 1,000 0,03723599 0,11893574 ! positive regulation of T cell activation GO:0050870 39 39 1,000 0,03723599 0,11872997 ! developmental maturation GO:0021700 39 39 1,000 0,03723599 0,11852491 ! rRNA transcription GO:0009303 5 5 0,000 0,03864402 0,1227947 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,03864402 0,12258335 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,03864402 0,12237273 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,03864402 0,12216282 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,03864402 0,12195364 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,03864402 0,12174517 ! reproductive cellular process GO:0048610 5 5 0,000 0,03864402 0,12153742 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,03864402 0,12133037 ! water transport GO:0006833 5 5 0,000 0,03864402 0,12112403 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,03864402 0,12091838 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,03864402 0,12071344 ! glycerol metabolic process GO:0006071 5 5 0,000 0,03864402 0,12050918 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,03864402 0,12030562 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,03864402 0,12010274 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,03864402 0,11990055 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,03864402 0,11969904 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,03864402 0,1194982 ! CTP metabolic process GO:0046036 5 5 0,000 0,03864402 0,11929803 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,03864402 0,11909854 ! GTP metabolic process GO:0046039 5 5 0,000 0,03864402 0,11889971 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,03864402 0,11870154 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,03864402 0,11850404 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,03864402 0,11830719 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,03864402 0,11811099 ! social behavior GO:0035176 5 5 0,000 0,03864402 0,11791544 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,03864402 0,11772054 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,03864402 0,11752628 ! dopamine receptor signaling pathway GO:0007212 5 5 0,000 0,03864402 0,11733266 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,03864402 0,11713968 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,03864402 0,11694733 ! response to lipid GO:0033993 5 5 0,000 0,03864402 0,11675562 ! erythrocyte maturation GO:0043249 5 5 0,000 0,03864402 0,11656453 ! hippocampus development GO:0021766 6 5 0,000 0,03864402 0,11637406 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,03864402 0,11618422 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,03864402 0,11599499 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,03864402 0,11580638 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,03864402 0,11561839 ! mechanosensory behavior GO:0007638 5 5 0,000 0,03864402 0,115431 ! heart looping GO:0001947 5 5 0,000 0,03864402 0,11524422 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,03864402 0,11505804 ! response to interferon-gamma GO:0034341 5 5 0,000 0,03864402 0,11487246 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,03864402 0,11468748 ! endocrine pancreas development GO:0031018 5 5 0,000 0,03864402 0,1145031 ! pH reduction GO:0045851 5 5 0,000 0,03864402 0,1143193 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,03864402 0,1141361 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,03864402 0,11395348 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,03864402 0,11377145 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,03864402 0,11358999 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,03864402 0,11340912 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,03864402 0,11322882 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,03864402 0,11304909 ! adrenal gland development GO:0030325 5 5 0,000 0,03864402 0,11286993 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,03864402 0,11269134 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,03864402 0,11251331 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,03864402 0,11233585 ! astrocyte differentiation GO:0048708 5 5 0,000 0,03864402 0,11215894 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,03864402 0,11198259 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,03864402 0,11180679 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,03864402 0,11163155 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,03864402 0,11145685 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,03864402 0,1112827 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,03864402 0,11110909 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,03864402 0,11093602 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,03864402 0,11076349 ! muscle cell migration GO:0014812 5 5 0,000 0,03864402 0,1105915 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,03864402 0,11042004 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,03864402 0,11024911 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,03864402 0,11007871 ! response to ATP GO:0033198 5 5 0,000 0,03864402 0,10990884 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,03864402 0,10973949 ! regulation of appetite GO:0032098 5 5 0,000 0,03864402 0,10957066 GO:0032095|regulation of response to food, ! paraxial mesoderm development GO:0048339 5 5 0,000 0,03864402 0,10940235 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,03864402 0,10923455 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,03864402 0,10906727 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03864402 0,1089005 ! receptor clustering GO:0043113 5 5 0,000 0,03864402 0,10873424 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,03864402 0,10856849 ! actin cytoskeleton reorganization GO:0031532 5 5 0,000 0,03864402 0,10840324 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,03864402 0,10823849 ! retinol metabolic process GO:0042572 5 5 0,000 0,03864402 0,10807424 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,03864402 0,1079105 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,03864402 0,10774724 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,03864402 0,10758448 ! parturition GO:0007567 5 5 0,000 0,03864402 0,10742221 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03864402 0,10726043 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,03864402 0,10709914 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,03864402 0,10693833 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,03864402 0,106778 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,03864402 0,10661815 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,03864402 0,10645878 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,03864402 0,10629989 ! oligodendrocyte development GO:0014003 5 5 0,000 0,03864402 0,10614147 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,03864402 0,10598352 ! activated T cell proliferation GO:0050798 5 5 0,000 0,03864402 0,10582604 ! interaction with symbiont GO:0051702 5 5 0,000 0,03864402 0,10566903 ! cellular extravasation GO:0045123 5 5 0,000 0,03864402 0,10551248 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,03864402 0,1053564 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,03864402 0,10520078 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,03864402 0,10504561 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,03864402 0,10489091 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,03864402 0,10473666 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,03864402 0,10458286 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,03864402 0,10442951 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,03864402 0,10427661 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,03864402 0,10412416 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,03864402 0,10397216 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,03864402 0,10382059 ! neuron recognition GO:0008038 5 5 0,000 0,03864402 0,10366947 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,03864402 0,10351879 ! decidualization GO:0046697 5 5 0,000 0,03864402 0,10336854 ! hair follicle maturation GO:0048820 5 5 0,000 0,03864402 0,10321873 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,03864402 0,10306936 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,03864402 0,10292041 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,03864402 0,1027719 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,03864402 0,10262381 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,03864402 0,10247615 ! postreplication repair GO:0006301 5 5 0,000 0,03864402 0,10232892 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,03864402 0,1021821 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,03864402 0,10203571 ! DNA methylation GO:0006306 5 5 0,000 0,03864402 0,10188974 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03864402 0,10174418 ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,03864402 0,10159904 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,03864402 0,10145431 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,03864402 0,10131 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,03864402 0,10116609 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,03864402 0,10102259 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,03864402 0,1008795 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,03864402 0,10073681 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,03864402 0,10059453 ! sterol catabolic process GO:0016127 5 5 0,000 0,03864402 0,10045265 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,03864402 0,10031116 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,03864402 0,10017008 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,03864402 0,10002939 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,03864402 0,0998891 ! zymogen activation GO:0031638 5 5 0,000 0,03864402 0,0997492 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,03864402 0,09960969 ! cellular response to nutrient GO:0031670 5 5 0,000 0,03864402 0,09947057 ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 0,03864402 0,09933184 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,03864402 0,09919349 ! nucleosome positioning GO:0016584 5 5 0,000 0,03864402 0,09905553 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,03864402 0,09891795 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,03864402 0,09878076 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,03864402 0,09864394 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,03864402 0,09850751 ! NADPH regeneration GO:0006740 5 5 0,000 0,03864402 0,09837145 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,03864402 0,09823576 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,03864402 0,09810045 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,03864402 0,09796551 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,03864402 0,09783094 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,03864402 0,09769674 ! sarcomere organization GO:0045214 5 5 0,000 0,03864402 0,09756291 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,03864402 0,09742945 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,03864402 0,09729635 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,03864402 0,09716361 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,03864402 0,09703124 GO:0045622|regulation of T-helper cell differentiation, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,03864402 0,09689922 ! male genitalia development GO:0030539 5 5 0,000 0,03864402 0,09676756 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,03864402 0,09663626 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,03864402 0,09650532 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,03864402 0,09637473 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,03864402 0,0962445 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,03864402 0,09611461 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,03864402 0,09598508 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,03864402 0,09585589 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,03864402 0,09572705 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,03864402 0,09559856 ! ATP catabolic process GO:0006200 5 5 0,000 0,03864402 0,09547041 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03864402 0,09534261 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,03864402 0,09521514 ! blastocyst formation GO:0001825 5 5 0,000 0,03864402 0,09508802 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,03864402 0,09496124 ! embryonic gut development GO:0048566 5 5 0,000 0,03864402 0,09483479 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,03864402 0,09470868 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,03864402 0,0945829 ! activation of innate immune response GO:0002218 5 5 0,000 0,03864402 0,09445746 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,03864402 0,09433235 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,03864402 0,09420758 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,03864402 0,09408313 ! muscle adaptation GO:0043500 5 5 0,000 0,03864402 0,09395901 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,03864402 0,09383521 ! embryonic heart tube development GO:0035050 5 5 0,000 0,03864402 0,09371175 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,03864402 0,0935886 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,03864402 0,09346578 ! defense response to fungus GO:0050832 5 5 0,000 0,03864402 0,09334329 ! lysogeny GO:0030069 5 5 0,000 0,03864402 0,09322111 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,03864402 0,09309925 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,03864402 0,09297771 ! establishment of cell polarity GO:0030010 5 5 0,000 0,03864402 0,09285649 ! mitochondrion localization GO:0051646 5 5 0,000 0,03864402 0,09273558 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,03864402 0,09261499 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,03900218 0,09335196 ! DNA catabolic process GO:0006308 41 40 1,000 0,03900218 0,09323089 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 0,03900218 0,09311012 ! myeloid cell differentiation GO:0030099 42 40 1,000 0,03900218 0,09298967 ! organelle localization GO:0051640 41 40 1,000 0,03900218 0,09286953 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,04079988 0,09702475 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 1,000 0,04079988 0,09689972 ! monosaccharide catabolic process GO:0046365 41 41 1,000 0,04079988 0,09677501 ! regulation of system process GO:0044057 98 98 2,000 0,04121965 0,09764501 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,04262852 0,10085284 ! cytosolic calcium ion homeostasis GO:0051480 42 42 1,000 0,04262852 0,10072354 ! response to protein stimulus GO:0051789 42 42 1,000 0,04262852 0,10059457 ! forebrain development GO:0030900 43 42 1,000 0,04262852 0,10046594 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 1,000 0,04262852 0,10033763 ! response to hormone stimulus GO:0009725 102 100 2,000 0,04334966 0,10190488 ! alcohol catabolic process GO:0046164 43 43 1,000 0,04448751 0,10444648 ! homeostasis of number of cells GO:0048872 44 43 1,000 0,04448751 0,1043136 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,04448751 0,10418105 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,04619503 0,10804244 ! axon extension GO:0048675 7 6 0,000 0,04619503 0,10790551 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,04619503 0,10776892 ! tRNA modification GO:0006400 6 6 0,000 0,04619503 0,10763268 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,04619503 0,10749678 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,04619503 0,10736122 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,04619503 0,107226 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,04619503 0,10709113 ! myotube differentiation GO:0014902 6 6 0,000 0,04619503 0,10695659 ! bone remodeling GO:0046849 6 6 0,000 0,04619503 0,10682239 ! N-glycan processing GO:0006491 6 6 0,000 0,04619503 0,10668853 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,04619503 0,106555 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,04619503 0,10642181 ! RNA methylation GO:0001510 6 6 0,000 0,04619503 0,10628895 ! cartilage condensation GO:0001502 7 6 0,000 0,04619503 0,10615642 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,04619503 0,10602422 ! succinate metabolic process GO:0006105 7 6 0,000 0,04619503 0,10589235 ! artery development GO:0060840 6 6 0,000 0,04619503 0,1057608 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,04619503 0,10562959 ! bile acid metabolic process GO:0008206 6 6 0,000 0,04619503 0,10549869 ! androgen metabolic process GO:0008209 6 6 0,000 0,04619503 0,10536813 ! estrogen metabolic process GO:0008210 6 6 0,000 0,04619503 0,10523788 ! limbic system development GO:0021761 7 6 0,000 0,04619503 0,10510796 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,04619503 0,10497836 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 0,000 0,04619503 0,10484907 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,04619503 0,10472011 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,04619503 0,10459146 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,04619503 0,10446312 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,04619503 0,10433511 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,04619503 0,1042074 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,04619503 0,10408001 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,04619503 0,10395293 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,04619503 0,10382615 ! arginine metabolic process GO:0006525 6 6 0,000 0,04619503 0,10369969 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,04619503 0,10357354 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,04619503 0,10344769 ! glutamate catabolic process GO:0006538 7 6 0,000 0,04619503 0,10332214 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,04619503 0,1031969 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,04619503 0,10307197 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,04619503 0,10294733 GO:0005978|glycogen biosynthetic process, ! V(D)J recombination GO:0033151 6 6 0,000 0,04619503 0,102823 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,04619503 0,10269897 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,04619503 0,10257524 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,04619503 0,1024518 ! regulation of heart rate GO:0002027 6 6 0,000 0,04619503 0,10232866 ! lipid digestion GO:0044241 6 6 0,000 0,04619503 0,10220582 ! asymmetric protein localization GO:0008105 6 6 0,000 0,04619503 0,10208327 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,04619503 0,10196101 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,04619503 0,10183905 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,04619503 0,10171738 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,04619503 0,101596 ! ruffle organization GO:0031529 6 6 0,000 0,04619503 0,10147491 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,04619503 0,1013541 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,04619503 0,10123359 ! neutral amino acid transport GO:0015804 6 6 0,000 0,04619503 0,10111336 ! L-amino acid transport GO:0015807 6 6 0,000 0,04619503 0,10099341 ! bone mineralization GO:0030282 6 6 0,000 0,04619503 0,10087375 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,04619503 0,10075437 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,04619503 0,10063528 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,04619503 0,10051647 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,04619503 0,10039793 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 0,04619503 0,10027968 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,04619503 0,1001617 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,04619503 0,100044 ! regulation of organ growth GO:0046620 6 6 0,000 0,04619503 0,09992658 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,04619503 0,09980943 ! response to dsRNA GO:0043331 6 6 0,000 0,04619503 0,09969256 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,04619503 0,09957596 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,04619503 0,09945963 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,04619503 0,09934358 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,04619503 0,09922779 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,04619503 0,09911228 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,04619503 0,09899703 ! multicellular organismal aging GO:0010259 6 6 0,000 0,04619503 0,09888205 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,04619503 0,09876734 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,04619503 0,09865289 ! erythrocyte development GO:0048821 6 6 0,000 0,04619503 0,09853871 ! renal water homeostasis GO:0003091 6 6 0,000 0,04619503 0,09842479 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,04619503 0,09831114 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,04619503 0,09819775 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,04619503 0,09808462 ! ribosome assembly GO:0042255 6 6 0,000 0,04619503 0,09797174 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,04619503 0,09785913 ! fucose catabolic process GO:0019317 6 6 0,000 0,04619503 0,09774678 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,04619503 0,09763469 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,04619503 0,09752285 ! regulation of lipid transport GO:0032368 6 6 0,000 0,04619503 0,09741127 ! regulation of cell division GO:0051302 6 6 0,000 0,04619503 0,09729994 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,04619503 0,09718887 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,04619503 0,09707805 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,04619503 0,09696748 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,04619503 0,09685716 ! neuroblast proliferation GO:0007405 6 6 0,000 0,04619503 0,0967471 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,04619503 0,09663728 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,04619503 0,09652772 ! regulation of glucose transport GO:0010827 6 6 0,000 0,04619503 0,0964184 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,04619503 0,09630933 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,04619503 0,0962005 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,04619503 0,09609193 ! lymph node development GO:0048535 6 6 0,000 0,04619503 0,09598359 ! organic cation transport GO:0015695 6 6 0,000 0,04619503 0,0958755 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,04619503 0,09576766 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,04619503 0,09566005 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,04619503 0,09555269 ! sperm-egg recognition GO:0035036 7 6 0,000 0,04619503 0,09544557 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,04619503 0,09533869 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,04619503 0,09523204 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,04619503 0,09512564 ! alditol metabolic process GO:0019400 6 6 0,000 0,04619503 0,09501947 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,04619503 0,09491354 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,04619503 0,09480785 ! maternal placenta development GO:0001893 6 6 0,000 0,04619503 0,09470239 ! humoral immune response GO:0006959 44 44 1,000 0,04637629 0,09496834 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 1,000 0,04637629 0,09486294 ! positive regulation of lymphocyte activation GO:0051251 44 44 1,000 0,04637629 0,09475777 ! amine biosynthetic process GO:0009309 46 45 1,000 0,0482943 0,09856743 ! homophilic cell adhesion GO:0007156 45 45 1,000 0,0482943 0,09845839 ! regulation of actin cytoskeleton organization GO:0032956 46 45 1,000 0,0482943 0,0983496 ! regulation of DNA binding GO:0051101 47 45 1,000 0,0482943 0,09824104 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 0,0482943 0,09813273 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 1,000 0,0482943 0,09802465 ! regulation of actin filament-based process GO:0032970 47 46 1,000 0,05024097 0,1018637 ! tube morphogenesis GO:0035239 47 46 1,000 0,05024097 0,10175176 ! regulation of peptidase activity GO:0052547 46 46 1,000 0,05024097 0,10164006 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 1,000 0,05024097 0,10152862 ! positive regulation of ligase activity GO:0051351 47 46 1,000 0,05024097 0,10141741 ! cellular response to hormone stimulus GO:0032870 48 46 1,000 0,05024097 0,10130645 ! amine transport GO:0015837 47 47 1,000 0,05221575 0,10517337 ! rhythmic process GO:0048511 47 47 1,000 0,05221575 0,10505855 ! respiratory burst GO:0045730 7 7 0,000 0,05368783 0,10790258 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,05368783 0,10778504 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,05368783 0,10766775 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,05368783 0,10755072 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,05368783 0,10743395 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,05368783 0,10731743 ! regulation of chemokine production GO:0032642 7 7 0,000 0,05368783 0,10720115 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,05368783 0,10708514 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,05368783 0,10696937 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,05368783 0,10685385 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,05368783 0,10673858 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,05368783 0,10662356 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,05368783 0,10650879 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,05368783 0,10639426 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,05368783 0,10627998 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,05368783 0,10616595 ! axis specification GO:0009798 7 7 0,000 0,05368783 0,10605216 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,05368783 0,10593861 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,05368783 0,10582531 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,05368783 0,10571225 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,05368783 0,10559943 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,05368783 0,10548685 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,05368783 0,10537451 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,05368783 0,10526241 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,05368783 0,10515055 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,05368783 0,10503892 ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,05368783 0,10492754 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,05368783 0,10481638 ! protein targeting to ER GO:0045047 8 7 0,000 0,05368783 0,10470547 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,05368783 0,10459478 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,05368783 0,10448434 ! endoderm development GO:0007492 7 7 0,000 0,05368783 0,10437412 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,05368783 0,10426414 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,05368783 0,10415439 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 0,05368783 0,10404486 ! response to hexose stimulus GO:0009746 7 7 0,000 0,05368783 0,10393557 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,05368783 0,10382651 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,05368783 0,10371768 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,05368783 0,10360907 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,05368783 0,1035007 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,05368783 0,10339255 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,05368783 0,10328462 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,05368783 0,10317692 ! response to X-ray GO:0010165 7 7 0,000 0,05368783 0,10306944 ! regulation of intracellular pH GO:0051453 7 7 0,000 0,05368783 0,10296219 ! UV protection GO:0009650 7 7 0,000 0,05368783 0,10285516 ! DNA integration GO:0015074 7 7 0,000 0,05368783 0,10274836 ! myofibril assembly GO:0030239 7 7 0,000 0,05368783 0,10264177 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,05368783 0,10253541 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,05368783 0,10242926 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,05368783 0,10232334 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,05368783 0,10221763 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,05368783 0,10211214 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,05368783 0,10200687 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,05368783 0,10190182 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,05368783 0,10179698 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,05368783 0,10169236 ! eating behavior GO:0042755 7 7 0,000 0,05368783 0,10158795 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,05368783 0,10148376 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,05368783 0,10137978 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,05368783 0,10127601 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,05368783 0,10117246 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,05368783 0,10106912 ! cranial nerve development GO:0021545 7 7 0,000 0,05368783 0,10096599 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,05368783 0,10086306 ! induction of an organ GO:0001759 7 7 0,000 0,05368783 0,10076035 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,05368783 0,10065785 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,05368783 0,10055555 ! autonomic nervous system development GO:0048483 7 7 0,000 0,05368783 0,10045347 ! intracellular lipid transport GO:0032365 7 7 0,000 0,05368783 0,10035159 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,05368783 0,10024991 ! platelet activation GO:0030168 8 7 0,000 0,05368783 0,10014845 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,05368783 0,10004719 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,05368783 0,09994613 ! natural killer cell activation GO:0030101 7 7 0,000 0,05368783 0,09984527 ! NADP metabolic process GO:0006739 7 7 0,000 0,05368783 0,09974462 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,05368783 0,09964418 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,05368783 0,09954393 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,05368783 0,09944389 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,05368783 0,09934404 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,05368783 0,0992444 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,05368783 0,09914496 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,05368783 0,09904571 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,05368783 0,09894667 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,05368783 0,09884782 ! cell-cell recognition GO:0009988 8 7 0,000 0,05368783 0,09874917 ! hormone catabolic process GO:0042447 7 7 0,000 0,05368783 0,09865071 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,05368783 0,09855246 ! oxygen transport GO:0015671 7 7 0,000 0,05368783 0,09845439 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,05368783 0,09835653 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,05368783 0,09825885 ! regulation of axon extension GO:0030516 7 7 0,000 0,05368783 0,09816137 ! cell killing GO:0001906 7 7 0,000 0,05368783 0,09806409 ! adult feeding behavior GO:0008343 7 7 0,000 0,05368783 0,097967 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,05368783 0,09787009 ! actin filament organization GO:0007015 50 48 1,000 0,05421812 0,09873912 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 1,000 0,05421812 0,09864165 ! regulation of cell cycle process GO:0010564 50 48 1,000 0,05421812 0,09854437 ! regulation of ligase activity GO:0051340 50 49 1,000 0,05624752 0,10213219 ! positive regulation of cell activation GO:0050867 49 49 1,000 0,05624752 0,10203167 GO:0002696|positive regulation of leukocyte activation, ! anatomical structure homeostasis GO:0060249 51 50 1,000 0,05830343 0,10565705 ! biogenic amine metabolic process GO:0006576 52 51 1,000 0,06038533 0,10932235 ! positive regulation of immune response GO:0050778 51 51 1,000 0,06038533 0,10921507 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,06112284 0,11044059 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,06112284 0,11033242 ! positive regulation of translation GO:0045727 8 8 0,000 0,06112284 0,11022446 ! superoxide anion generation GO:0042554 8 8 0,000 0,06112284 0,11011671 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,06112284 0,11000918 ! cGMP metabolic process GO:0046068 8 8 0,000 0,06112284 0,10990185 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,06112284 0,10979474 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,06112284 0,10968783 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,06112284 0,10958113 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,06112284 0,10947463 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,06112284 0,10936835 ! zinc ion transport GO:0006829 8 8 0,000 0,06112284 0,10926227 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,06112284 0,10915639 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,06112284 0,10905072 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,06112284 0,10894526 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,06112284 0,10884 ! response to pain GO:0048265 8 8 0,000 0,06112284 0,10873494 ! response to cAMP GO:0051591 8 8 0,000 0,06112284 0,10863009 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,06112284 0,10852543 GO:0048200|Golgi transport vesicle coating, ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,06112284 0,10842098 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,06112284 0,10831673 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,06112284 0,10821268 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,06112284 0,10810883 ! sensory perception of taste GO:0050909 8 8 0,000 0,06112284 0,10800518 ! pancreas development GO:0031016 8 8 0,000 0,06112284 0,10790172 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,06112284 0,10779847 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,06112284 0,10769541 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,06112284 0,10759255 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,06112284 0,10748988 ! sperm motility GO:0030317 8 8 0,000 0,06112284 0,10738742 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,06112284 0,10728514 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,06112284 0,10718306 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,06112284 0,10708118 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,06112284 0,10697949 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,06112284 0,10687799 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,06112284 0,10677668 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,06112284 0,10667557 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,06112284 0,10657464 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,06112284 0,10647391 ! fructose metabolic process GO:0006000 8 8 0,000 0,06112284 0,10637337 ! mannose metabolic process GO:0006013 9 8 0,000 0,06112284 0,10627302 ! NAD metabolic process GO:0019674 8 8 0,000 0,06112284 0,10617285 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,06112284 0,10607288 ! response to fungus GO:0009620 8 8 0,000 0,06112284 0,10597309 ! stem cell differentiation GO:0048863 8 8 0,000 0,06112284 0,10587349 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,06112284 0,10577408 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,06112284 0,10567486 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,06112284 0,10557582 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,06112284 0,10547696 ! vasoconstriction GO:0042310 8 8 0,000 0,06112284 0,1053783 ! muscle cell development GO:0055001 8 8 0,000 0,06112284 0,10527981 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,06112284 0,10518151 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,06112284 0,10508339 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,06112284 0,10498546 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,06112284 0,10488771 ! chromatin silencing GO:0006342 8 8 0,000 0,06112284 0,10479014 ! tissue regeneration GO:0042246 8 8 0,000 0,06112284 0,10469275 ! salivary gland development GO:0007431 8 8 0,000 0,06112284 0,10459554 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,06112284 0,10449851 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,06112284 0,10440167 ! water homeostasis GO:0030104 8 8 0,000 0,06112284 0,104305 ! cofactor transport GO:0051181 8 8 0,000 0,06112284 0,10420851 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,06112284 0,1041122 ! acid secretion GO:0046717 8 8 0,000 0,06112284 0,10401607 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,06112284 0,10392011 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,06112284 0,10382433 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,06112284 0,10372873 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,06112284 0,1036333 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,06112284 0,10353805 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,06112284 0,10344297 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,06112284 0,10334807 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,06112284 0,10325334 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,06112284 0,10315879 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,06112284 0,10306441 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,06112284 0,1029702 ! developmental induction GO:0031128 8 8 0,000 0,06112284 0,10287616 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,06112284 0,1027823 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,06112284 0,1026886 ! actin filament polymerization GO:0030041 9 8 0,000 0,06112284 0,10259508 ! cytoplasmic sequestering of protein GO:0051220 8 8 0,000 0,06112284 0,10250173 ! peptide hormone processing GO:0016486 8 8 0,000 0,06112284 0,10240854 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,06112284 0,10231553 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,06112284 0,10222268 ! regulation of GTPase activity GO:0043087 53 52 1,000 0,06249269 0,10441888 ! carbohydrate catabolic process GO:0016052 53 53 1,000 0,06462501 0,10788396 ! regulation of protein transport GO:0051223 53 53 1,000 0,06462501 0,10778633 GO:0070201|regulation of establishment of protein localization, ! lactation GO:0007595 10 9 0,000 0,06850051 0,11414688 ! embryonic pattern specification GO:0009880 10 9 0,000 0,06850051 0,11404377 ! positive regulation of cell size GO:0045793 9 9 0,000 0,06850051 0,11394084 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,06850051 0,1138381 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,06850051 0,11373554 ! negative regulation of cell cycle process GO:0010948 9 9 0,000 0,06850051 0,11363317 ! viral genome replication GO:0019079 9 9 0,000 0,06850051 0,11353098 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,06850051 0,11342897 ! copper ion transport GO:0006825 9 9 0,000 0,06850051 0,11332715 ! lipid phosphorylation GO:0046834 9 9 0,000 0,06850051 0,11322551 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,06850051 0,11312406 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,06850051 0,11302278 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,06850051 0,11292169 ! RNA polyadenylation GO:0043631 9 9 0,000 0,06850051 0,11282078 GO:0006378|mRNA polyadenylation, ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,06850051 0,11272004 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,06850051 0,11261949 ! phospholipid efflux GO:0033700 9 9 0,000 0,06850051 0,11251912 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,06850051 0,11241892 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,06850051 0,1123189 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,06850051 0,11221907 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,06850051 0,1121194 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,06850051 0,11201992 ! methionine metabolic process GO:0006555 9 9 0,000 0,06850051 0,11192061 ! glutamine metabolic process GO:0006541 9 9 0,000 0,06850051 0,11182148 ! cerebral cortex development GO:0021987 9 9 0,000 0,06850051 0,11172252 ! response to osmotic stress GO:0006970 9 9 0,000 0,06850051 0,11162374 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,06850051 0,11152513 ! central nervous system neuron development GO:0021954 10 9 0,000 0,06850051 0,1114267 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,06850051 0,11132844 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,06850051 0,11123035 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,06850051 0,11113244 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,06850051 0,1110347 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,06850051 0,11093713 ! L-glutamate transport GO:0015813 9 9 0,000 0,06850051 0,11083973 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,06850051 0,1107425 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,06850051 0,11064544 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,06850051 0,11054855 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,06850051 0,11045184 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,06850051 0,11035529 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,06850051 0,11025891 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,06850051 0,1101627 ! positive regulation of protein import into nucleus GO:0042307 9 9 0,000 0,06850051 0,11006665 ! DNA replication initiation GO:0006270 9 9 0,000 0,06850051 0,10997077 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,06850051 0,10987506 GO:0006692|prostanoid metabolic process, ! regulation of cellular pH GO:0030641 9 9 0,000 0,06850051 0,10977952 ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,06850051 0,10968414 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,06850051 0,10958893 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,06850051 0,10949388 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,06850051 0,109399 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,06850051 0,10930428 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,06850051 0,10920973 ! collagen catabolic process GO:0030574 9 9 0,000 0,06850051 0,10911534 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,06850051 0,10902111 ! purine base metabolic process GO:0006144 9 9 0,000 0,06850051 0,10892705 ! gas transport GO:0015669 9 9 0,000 0,06850051 0,10883315 ! cholesterol efflux GO:0033344 9 9 0,000 0,06850051 0,1087394 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,06850051 0,10864583 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,06850051 0,10855241 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,06850051 0,10845915 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,06850051 0,10836605 ! actin filament-based movement GO:0030048 9 9 0,000 0,06850051 0,10827311 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,06850051 0,10818033 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,07582128 0,11963923 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,07582128 0,11953688 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 0,000 0,07582128 0,11943472 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,07582128 0,11933272 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,07582128 0,1192309 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! neuron maturation GO:0042551 10 10 0,000 0,07582128 0,11912926 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,07582128 0,11902778 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,07582128 0,11892648 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,07582128 0,11882536 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,07582128 0,1187244 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,07582128 0,11862361 ! hormone secretion GO:0046879 10 10 0,000 0,07582128 0,118523 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,07582128 0,11842256 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,07582128 0,11832228 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 0,000 0,07582128 0,11822218 ! inositol metabolic process GO:0006020 10 10 0,000 0,07582128 0,11812225 ! cAMP metabolic process GO:0046058 10 10 0,000 0,07582128 0,11802248 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,07582128 0,11792288 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,07582128 0,11782346 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,07582128 0,11772419 ! glial cell development GO:0021782 10 10 0,000 0,07582128 0,1176251 ! phototransduction GO:0007602 11 10 0,000 0,07582128 0,11752617 ! fat cell differentiation GO:0045444 10 10 0,000 0,07582128 0,11742741 ! myoblast differentiation GO:0045445 10 10 0,000 0,07582128 0,11732881 ! centrosome cycle GO:0007098 10 10 0,000 0,07582128 0,11723038 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,07582128 0,11713212 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,07582128 0,11703402 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,07582128 0,11693608 ! protein polyubiquitination GO:0000209 10 10 0,000 0,07582128 0,11683831 ! glutamate metabolic process GO:0006536 11 10 0,000 0,07582128 0,1167407 ! plasma membrane organization GO:0007009 10 10 0,000 0,07582128 0,11664325 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,07582128 0,11654597 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,07582128 0,11644885 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,07582128 0,11635189 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,07582128 0,11625509 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,07582128 0,11615845 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,07582128 0,11606198 ! exocrine system development GO:0035272 10 10 0,000 0,07582128 0,11596566 ! embryo implantation GO:0007566 11 10 0,000 0,07582128 0,1158695 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,07582128 0,1157735 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,07582128 0,11567766 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,07582128 0,11558198 ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,07582128 0,11548646 ! protein export from nucleus GO:0006611 10 10 0,000 0,07582128 0,1153911 ! cytolysis GO:0019835 10 10 0,000 0,07582128 0,11529589 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,07582128 0,11520084 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,07582128 0,11510595 ! histone deacetylation GO:0016575 10 10 0,000 0,07582128 0,11501121 ! mRNA splice site selection GO:0006376 11 10 0,000 0,07582128 0,11491663 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,07582128 0,1148222 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,07582128 0,11472793 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,07582128 0,11463381 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,07582128 0,11453985 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,07582128 0,11444604 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,07582128 0,11435239 ! regulation of epidermis development GO:0045682 10 10 0,000 0,07582128 0,11425889 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,07582128 0,11416554 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,07582128 0,11407234 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,07582128 0,1139793 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,07582128 0,1138864 ! nerve development GO:0021675 10 10 0,000 0,07582128 0,11379366 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,07582128 0,11370107 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,07582128 0,11360863 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,07582128 0,11351634 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,07582128 0,1134242 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,07582128 0,11333221 ! protein stabilization GO:0050821 10 10 0,000 0,07582128 0,11324037 ! carboxylic acid transport GO:0046942 59 59 1,000 0,07791519 0,11627344 GO:0015849|organic acid transport, ! cellular aromatic compound metabolic process GO:0006725 60 59 1,000 0,07791519 0,11617937 ! protein polymerization GO:0051258 65 60 1,000 0,08020842 0,11950212 ! cellular respiration GO:0045333 62 61 1,000 0,08252273 0,12285089 ! proteasomal protein catabolic process GO:0010498 62 61 1,000 0,08252273 0,12275173 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 1,000 0,08252273 0,12265274 ! protein secretion GO:0009306 11 11 0,000 0,08308557 0,12338977 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,08308557 0,12329042 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,08308557 0,12319123 ! negative regulation of defense response GO:0031348 11 11 0,000 0,08308557 0,1230922 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,08308557 0,12299333 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,08308557 0,12289462 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,08308557 0,12279607 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,08308557 0,12269768 ! skin development GO:0043588 11 11 0,000 0,08308557 0,12259944 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,08308557 0,12250136 ! signal complex assembly GO:0007172 11 11 0,000 0,08308557 0,12240344 ! endothelial cell migration GO:0043542 11 11 0,000 0,08308557 0,12230567 ! peroxisomal transport GO:0043574 11 11 0,000 0,08308557 0,12220806 ! protein amino acid methylation GO:0006479 11 11 0,000 0,08308557 0,1221106 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,08308557 0,12201331 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,08308557 0,12191616 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,08308557 0,12181917 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,08308557 0,12172234 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! spinal cord development GO:0021510 11 11 0,000 0,08308557 0,12162565 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,08308557 0,12152913 ! smooth muscle contraction GO:0006939 11 11 0,000 0,08308557 0,12143275 ! cellular response to starvation GO:0009267 11 11 0,000 0,08308557 0,12133653 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,08308557 0,12124046 ! digestive system process GO:0022600 11 11 0,000 0,08308557 0,12114454 ! mitotic spindle organization GO:0007052 11 11 0,000 0,08308557 0,12104877 ! fucose metabolic process GO:0006004 11 11 0,000 0,08308557 0,12095316 ! membrane budding GO:0006900 11 11 0,000 0,08308557 0,12085769 ! monoamine transport GO:0015844 11 11 0,000 0,08308557 0,12076238 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,08308557 0,12066722 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,08308557 0,1205722 ! body fluid secretion GO:0007589 11 11 0,000 0,08308557 0,12047734 ! G1/S transition checkpoint GO:0031575 12 11 0,000 0,08308557 0,12038262 ! intermediate filament-based process GO:0045103 11 11 0,000 0,08308557 0,12028806 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,08308557 0,12019364 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,08308557 0,12009937 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,08308557 0,12000525 ! vitamin transport GO:0051180 11 11 0,000 0,08308557 0,11991128 ! muscle maintenance GO:0046716 12 11 0,000 0,08308557 0,11981745 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,08308557 0,11972377 ! steroid catabolic process GO:0006706 11 11 0,000 0,08308557 0,11963023 ! endocrine process GO:0050886 11 11 0,000 0,08308557 0,11953685 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,08308557 0,1194436 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,08308557 0,11935051 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,08308557 0,11925755 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,08308557 0,11916475 ! lipid transport GO:0006869 62 62 1,000 0,08485768 0,12161174 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,08485768 0,12151725 GO:0060429|epithelium development, ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,0872128 0,12479284 ! glucose metabolic process GO:0006006 63 63 1,000 0,0872128 0,12469603 ! glycerolipid metabolic process GO:0046486 65 64 1,000 0,08958765 0,12799227 ! positive regulation of protein metabolic process GO:0051247 64 64 1,000 0,08958765 0,12789313 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,0902938 0,12880145 ! translational initiation GO:0006413 12 12 0,000 0,0902938 0,12870184 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,0902938 0,12860238 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,0902938 0,12850307 ! initiation of viral infection GO:0019059 12 12 0,000 0,0902938 0,12840392 ! iron ion transport GO:0006826 13 12 0,000 0,0902938 0,12830492 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,0902938 0,12820607 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,0902938 0,12810737 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,0902938 0,12800883 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,0902938 0,12791044 ! collagen metabolic process GO:0032963 12 12 0,000 0,0902938 0,1278122 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,0902938 0,12771411 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,0902938 0,12761617 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,0902938 0,12751837 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,0902938 0,12742073 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,0902938 0,12732324 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,0902938 0,1272259 ! actomyosin structure organization GO:0031032 12 12 0,000 0,0902938 0,12712871 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,0902938 0,12703166 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,0902938 0,12693477 ! retinoid metabolic process GO:0001523 12 12 0,000 0,0902938 0,12683802 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,0902938 0,12674142 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,0902938 0,12664496 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,0902938 0,12654865 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,0902938 0,12645249 ! acute-phase response GO:0006953 12 12 0,000 0,0902938 0,12635648 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,0902938 0,12626061 ! vacuolar transport GO:0007034 12 12 0,000 0,0902938 0,12616488 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,0902938 0,1260693 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,0902938 0,12597387 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,0902938 0,12587858 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,0902938 0,12578343 GO:0051693|actin filament capping, ! regulation of insulin secretion GO:0050796 12 12 0,000 0,0902938 0,12568843 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,0902938 0,12559357 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,0902938 0,12549885 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,0902938 0,12540428 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,0902938 0,12530985 ! pallium development GO:0021543 13 12 0,000 0,0902938 0,12521556 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,0902938 0,12512141 ! G1 phase GO:0051318 13 12 0,000 0,0902938 0,12502741 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,0902938 0,12493354 ! detection of light stimulus GO:0009583 13 12 0,000 0,0902938 0,12483982 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,0902938 0,12474624 ! hormone transport GO:0009914 12 12 0,000 0,0902938 0,12465279 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,0902938 0,12455949 ! heme biosynthetic process GO:0006783 12 12 0,000 0,0902938 0,12446633 ! spermatid differentiation GO:0048515 13 12 0,000 0,0902938 0,1243733 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,0902938 0,12428042 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,0902938 0,12418767 ! neural tube closure GO:0001843 13 12 0,000 0,0902938 0,12409506 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 0,000 0,0902938 0,12400259 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,0902938 0,12391026 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,09439478 0,12944166 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,09744641 0,13352695 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,09744641 0,13342774 ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,09744641 0,13332869 ! gluconeogenesis GO:0006094 13 13 0,000 0,09744641 0,13322978 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,09744641 0,13313102 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,09744641 0,1330324 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,09744641 0,13293393 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,09744641 0,13283561 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,09744641 0,13273743 ! keratinization GO:0031424 13 13 0,000 0,09744641 0,1326394 ! patterning of blood vessels GO:0001569 13 13 0,000 0,09744641 0,13254151 ! regulation of innate immune response GO:0045088 13 13 0,000 0,09744641 0,13244376 ! negative regulation of DNA replication GO:0008156 13 13 0,000 0,09744641 0,13234616 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,09744641 0,13224871 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,09744641 0,13215139 ! autophagy GO:0006914 13 13 0,000 0,09744641 0,13205422 ! receptor metabolic process GO:0043112 14 13 0,000 0,09744641 0,13195719 ! actin filament bundle formation GO:0051017 13 13 0,000 0,09744641 0,13186031 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,09744641 0,13176357 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,09744641 0,13166697 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,09744641 0,13157051 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,09744641 0,13147419 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,09744641 0,13137801 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,09744641 0,13128198 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,09744641 0,13118608 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,09744641 0,13109032 ! vasodilation GO:0042311 14 13 0,000 0,09744641 0,13099471 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,09744641 0,13089923 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,09744641 0,13080389 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,09744641 0,13070869 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,09744641 0,13061363 ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,09744641 0,13051871 ! negative regulation of intracellular transport GO:0032387 13 13 0,000 0,09744641 0,13042392 ! cell-cell junction organization GO:0045216 13 13 0,000 0,09744641 0,13032928 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,09744641 0,13023477 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,09744641 0,13014039 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,09744641 0,13004616 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,09744641 0,12995206 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,09744641 0,12985809 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,09744641 0,12976426 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,09744641 0,12967057 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,09744641 0,12957701 ! blastocyst development GO:0001824 13 13 0,000 0,09744641 0,12948359 ! telomere organization GO:0032200 13 13 0,000 0,09744641 0,1293903 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,09744641 0,12929715 ! regulation of amine transport GO:0051952 13 13 0,000 0,09744641 0,12920413 ! regulation of translation GO:0006417 69 69 1,000 0,10174263 0,1348035 ! regulation of mitotic cell cycle GO:0007346 72 69 1,000 0,10174263 0,13470666 ! positive regulation of transport GO:0051050 71 70 1,000 0,1042268 0,13789663 ! wound healing GO:0042060 74 70 1,000 0,1042268 0,1377977 ! carboxylic acid biosynthetic process GO:0046394 70 70 1,000 0,1042268 0,13769892 GO:0016053|organic acid biosynthetic process, ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,10454382 0,13801881 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,10454382 0,13792002 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,10454382 0,13782136 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,10454382 0,13772285 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,10454382 0,13762447 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,10454382 0,13752624 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,10454382 0,13742815 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,10454382 0,13733019 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,10454382 0,13723238 ! superoxide metabolic process GO:0006801 15 14 0,000 0,10454382 0,13713471 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,10454382 0,13703717 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,10454382 0,13693977 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,10454382 0,13684252 ! lysosome organization GO:0007040 14 14 0,000 0,10454382 0,1367454 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,10454382 0,13664841 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,10454382 0,13655157 ! peptide transport GO:0015833 14 14 0,000 0,10454382 0,13645486 ! primary neural tube formation GO:0014020 15 14 0,000 0,10454382 0,13635829 ! peptide cross-linking GO:0018149 14 14 0,000 0,10454382 0,13626186 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,10454382 0,13616556 ! base-excision repair GO:0006284 14 14 0,000 0,10454382 0,13606939 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,10454382 0,13597337 ! formation of primary germ layer GO:0001704 14 14 0,000 0,10454382 0,13587748 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,10454382 0,13578172 ! collagen fibril organization GO:0030199 14 14 0,000 0,10454382 0,1356861 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,10454382 0,13559061 ! positive regulation of inflammatory response GO:0050729 14 14 0,000 0,10454382 0,13549526 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,10454382 0,13540004 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,10454382 0,13530496 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,10454382 0,13521001 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,10454382 0,13511519 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,10454382 0,13502051 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,10454382 0,13492595 ! positive regulation of hydrolase activity GO:0051345 72 72 1,000 0,10924502 0,14089473 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,11158644 0,14381386 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,11158644 0,14371336 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,11158644 0,143613 ! positive regulation of ossification GO:0045778 15 15 0,000 0,11158644 0,14351278 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,11158644 0,1434127 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,11158644 0,14331276 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,11158644 0,14321296 ! regulation of transcription factor import into nucleus GO:0042990 15 15 0,000 0,11158644 0,1431133 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,11158644 0,14301378 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,11158644 0,14291439 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,11158644 0,14281515 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,11158644 0,14271604 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,11158644 0,14261707 ! heme metabolic process GO:0042168 15 15 0,000 0,11158644 0,14251823 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,11158644 0,14241954 ! chromosome condensation GO:0030261 15 15 0,000 0,11158644 0,14232098 ! response to starvation GO:0042594 15 15 0,000 0,11158644 0,14222255 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,11158644 0,14212427 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,11158644 0,14202611 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,11158644 0,1419281 GO:0030500|regulation of bone mineralization, ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,11158644 0,14183022 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,11158644 0,14173247 ! phospholipid transport GO:0015914 15 15 0,000 0,11158644 0,14163486 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,11158644 0,14153738 ! glutathione metabolic process GO:0006749 16 15 0,000 0,11158644 0,14144004 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,11158644 0,14134283 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,11158644 0,14124575 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,11158644 0,14114881 ! negative regulation of transcription factor activity GO:0043433 16 15 0,000 0,11158644 0,141052 GO:0090048|negative regulation of transcription regulator activity, ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,11158644 0,14095532 ! coenzyme metabolic process GO:0006732 75 74 1,000 0,11432707 0,14431835 ! response to oxidative stress GO:0006979 76 75 1,000 0,11689105 0,14745394 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,11857469 0,14947548 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,11857469 0,14937331 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,11857469 0,14927128 ! circadian rhythm GO:0007623 16 16 0,000 0,11857469 0,14916939 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,11857469 0,14906764 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,11857469 0,14896602 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,11857469 0,14886455 ! vacuole organization GO:0007033 16 16 0,000 0,11857469 0,14876321 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,11857469 0,14866201 ! vesicle targeting GO:0006903 17 16 0,000 0,11857469 0,14856095 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,11857469 0,14846002 ! iron ion homeostasis GO:0055072 16 16 0,000 0,11857469 0,14835924 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,11857469 0,14825859 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,11857469 0,14815807 ! cell fate specification GO:0001708 16 16 0,000 0,11857469 0,14805769 ! pentose metabolic process GO:0019321 16 16 0,000 0,11857469 0,14795745 ! fatty acid transport GO:0015908 16 16 0,000 0,11857469 0,14785735 ! cellular response to nutrient levels GO:0031669 16 16 0,000 0,11857469 0,14775737 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,11857469 0,14765754 ! polyol metabolic process GO:0019751 16 16 0,000 0,11857469 0,14755784 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,11857469 0,14745827 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,11857469 0,14735884 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,11857469 0,14725954 GO:0001841|neural tube formation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,11857469 0,14716037 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,11857469 0,14706134 ! positive regulation of protein kinase cascade GO:0010740 79 78 1,000 0,12467023 0,1545173 ! regulation of immune response GO:0050776 78 78 1,000 0,12467023 0,15441346 ! regulation of fibroblast proliferation GO:0048145 17 17 0,000 0,12550898 0,15534792 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,12550898 0,15524366 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,12550898 0,15513954 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,12550898 0,15503556 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,12550898 0,15493172 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,12550898 0,15482801 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,12550898 0,15472445 ! sensory perception of smell GO:0007608 17 17 0,000 0,12550898 0,15462102 ! glucose transport GO:0015758 17 17 0,000 0,12550898 0,15451774 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,12550898 0,15441459 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,12550898 0,15431158 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,12550898 0,1542087 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,12550898 0,15410596 ! neural crest cell development GO:0014032 19 17 0,000 0,12550898 0,15400336 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 18 17 0,000 0,12550898 0,1539009 GO:0050768|negative regulation of neurogenesis, ! cell recognition GO:0008037 18 17 0,000 0,12550898 0,15379857 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,12550898 0,15369638 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,12550898 0,15359432 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,12550898 0,1534924 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,12550898 0,15339062 ! adult locomotory behavior GO:0008344 17 17 0,000 0,12550898 0,15328897 ! embryonic organ development GO:0048568 17 17 0,000 0,12550898 0,15318745 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,12550898 0,15308607 ! gene silencing GO:0016458 17 17 0,000 0,12550898 0,15298482 ! nuclear transport GO:0051169 79 79 1,000 0,12729112 0,15505455 GO:0006913|nucleocytoplasmic transport, ! mRNA export from nucleus GO:0006406 18 18 0,000 0,13238972 0,16115869 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,13238972 0,16105231 ! meiosis I GO:0007127 18 18 0,000 0,13238972 0,16094608 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,13238972 0,16083998 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,13238972 0,16073403 ! response to calcium ion GO:0051592 18 18 0,000 0,13238972 0,16062821 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,13238972 0,16052254 ! hexose transport GO:0008645 18 18 0,000 0,13238972 0,160417 GO:0015749|monosaccharide transport, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 0,000 0,13238972 0,1603116 ! striated muscle contraction GO:0006941 18 18 0,000 0,13238972 0,16020634 ! negative regulation of DNA binding GO:0043392 19 18 0,000 0,13238972 0,16010122 ! ceramide metabolic process GO:0006672 18 18 0,000 0,13238972 0,15999623 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,13238972 0,15989139 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,13238972 0,15978668 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,13238972 0,1596821 ! cellular response to extracellular stimulus GO:0031668 18 18 0,000 0,13238972 0,15957767 ! BMP signaling pathway GO:0030509 18 18 0,000 0,13238972 0,15947337 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,13238972 0,15936921 ! lipid catabolic process GO:0016042 82 81 1,000 0,13257246 0,15948501 ! DNA damage checkpoint GO:0000077 19 19 0,000 0,13921732 0,16736955 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,13921732 0,16726044 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,13921732 0,16715147 GO:0006956|complement activation, ! negative regulation of DNA metabolic process GO:0051053 19 19 0,000 0,13921732 0,16704265 ! glial cell differentiation GO:0010001 19 19 0,000 0,13921732 0,16693397 ! regulation of pH GO:0006885 19 19 0,000 0,13921732 0,16682543 ! feeding behavior GO:0007631 19 19 0,000 0,13921732 0,16671703 ! peroxisome organization GO:0007031 19 19 0,000 0,13921732 0,16660877 ! multicellular organismal metabolic process GO:0044236 19 19 0,000 0,13921732 0,16650066 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,13921732 0,16639268 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,13921732 0,16628484 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,13921732 0,16617715 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,13921732 0,16606959 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,13921732 0,16596217 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,13921732 0,16585489 ! eye morphogenesis GO:0048592 19 19 0,000 0,13921732 0,16574775 ! placenta development GO:0001890 19 19 0,000 0,13921732 0,16564074 ! vesicle localization GO:0051648 20 19 0,000 0,13921732 0,16553388 ! cellular amino acid derivative metabolic process GO:0006575 87 84 1,000 0,14058803 0,16705593 ! regulation of cellular localization GO:0060341 86 85 1,000 0,14328345 0,1701491 ! nitrogen compound biosynthetic process GO:0044271 86 85 1,000 0,14328345 0,17003954 ! hexose metabolic process GO:0019318 87 86 1,000 0,14599009 0,17314011 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,14599217 0,17303123 ! negative regulation of binding GO:0051100 21 20 0,000 0,14599217 0,17292003 ! neural tube development GO:0021915 21 20 0,000 0,14599217 0,17280897 ! phagocytosis GO:0006909 21 20 0,000 0,14599217 0,17269805 ! positive regulation of gene-specific transcription GO:0043193 20 20 0,000 0,14599217 0,17258728 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,14599217 0,17247665 ! protein targeting to membrane GO:0006612 22 20 0,000 0,14599217 0,17236615 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,14599217 0,1722558 ! lipid oxidation GO:0034440 20 20 0,000 0,14599217 0,1721456 GO:0019395|fatty acid oxidation, ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,14599217 0,17203553 ! RNA modification GO:0009451 20 20 0,000 0,14599217 0,1719256 ! single fertilization GO:0007338 21 20 0,000 0,14599217 0,17181582 ! male gamete generation GO:0048232 90 88 1,000 0,15143568 0,17810846 GO:0007283|spermatogenesis, ! mitotic sister chromatid segregation GO:0000070 21 21 0,000 0,15271468 0,17949818 ! mRNA catabolic process GO:0006402 21 21 0,000 0,15271468 0,17938378 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,15271468 0,17926952 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,15271468 0,17915541 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,15271468 0,17904145 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,15271468 0,17892762 ! ear morphogenesis GO:0042471 21 21 0,000 0,15271468 0,17881395 ! organic anion transport GO:0015711 21 21 0,000 0,15271468 0,17870042 ! spliceosome assembly GO:0000245 22 21 0,000 0,15271468 0,17858703 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,15271468 0,17847378 GO:0032313|regulation of Rab GTPase activity, ! DNA integrity checkpoint GO:0031570 21 21 0,000 0,15271468 0,17836068 ! regulation of protein import into nucleus GO:0042306 21 21 0,000 0,15271468 0,17824772 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,15271468 0,17813491 ! regulation of proteolysis GO:0030162 21 21 0,000 0,15271468 0,17802224 ! negative regulation of hydrolase activity GO:0051346 21 21 0,000 0,15271468 0,17790971 ! negative regulation of protein transport GO:0051224 21 21 0,000 0,15271468 0,17779732 ! chemotaxis GO:0006935 90 89 1,000 0,15417398 0,17938298 GO:0042330|taxis, ! regulation of Ras protein signal transduction GO:0046578 90 90 1,000 0,15692219 0,18246536 ! RNA export from nucleus GO:0006405 22 22 0,000 0,15938524 0,18521249 ! sister chromatid segregation GO:0000819 22 22 0,000 0,15938524 0,18509578 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,15938524 0,18497922 ! regulation of ion transport GO:0043269 22 22 0,000 0,15938524 0,18486281 ! odontogenesis GO:0042476 22 22 0,000 0,15938524 0,18474654 ! hormone-mediated signaling GO:0009755 22 22 0,000 0,15938524 0,18463042 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,15938524 0,18451445 ! maintenance of protein location in cell GO:0032507 23 22 0,000 0,15938524 0,18439862 ! spindle organization GO:0007051 22 22 0,000 0,15938524 0,18428294 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,15938524 0,1841674 ! cell chemotaxis GO:0060326 23 22 0,000 0,15938524 0,18405201 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,15938524 0,18393676 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,15938524 0,18382166 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,15938524 0,1837067 ! biopolymer methylation GO:0043414 22 22 0,000 0,15938524 0,18359188 GO:0032259|methylation, ! neuron migration GO:0001764 22 22 0,000 0,15938524 0,18347721 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,15938524 0,18336268 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,15938524 0,18324829 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,15938524 0,18313404 ! cytokine production GO:0001816 22 22 0,000 0,15938524 0,18301994 ! cytokinesis GO:0000910 23 22 0,000 0,15938524 0,18290598 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,15938524 0,18279216 ! tissue morphogenesis GO:0048729 94 93 1,000 0,16522317 0,18936959 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,16600426 0,19014658 ! viral infectious cycle GO:0019058 23 23 0,000 0,16600426 0,19002848 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,16600426 0,18991052 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,16600426 0,18979271 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,16600426 0,18967505 ! mitotic cell cycle checkpoint GO:0007093 24 23 0,000 0,16600426 0,18955753 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,16600426 0,18944015 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,16600426 0,18932293 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,16600426 0,18920584 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,16600426 0,1890889 ! epidermis development GO:0008544 94 94 1,000 0,16800792 0,19125299 ! cofactor metabolic process GO:0051186 95 94 1,000 0,16800792 0,19113493 ! gliogenesis GO:0042063 24 24 0,000 0,17257211 0,19620629 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,17257211 0,19608533 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,17257211 0,19596451 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,17257211 0,19584384 ! fertilization GO:0009566 25 24 0,000 0,17257211 0,19572332 ! maintenance of protein location GO:0045185 25 24 0,000 0,17257211 0,19560295 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,17257211 0,19548273 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,17908919 0,20274041 ! negative regulation of secretion GO:0051048 26 25 0,000 0,17908919 0,20261595 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,17908919 0,20249165 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,17908919 0,20236749 ! endosome transport GO:0016197 25 25 0,000 0,17908919 0,20224349 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,17908919 0,20211965 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,17908919 0,20199595 ! excretion GO:0007588 25 25 0,000 0,17908919 0,2018724 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,17908919 0,20174901 ! gastrulation GO:0007369 25 25 0,000 0,17908919 0,20162577 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,17908919 0,20150267 ! regulation of endocytosis GO:0030100 25 25 0,000 0,17908919 0,20137973 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,17908919 0,20125694 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,17908919 0,2011343 ! endocytosis GO:0006897 99 98 1,000 0,17922772 0,20116729 GO:0010324|membrane invagination, ! blood circulation GO:0008015 99 98 1,000 0,17922772 0,20104485 GO:0003013|circulatory system process, ! ectoderm development GO:0007398 99 99 1,000 0,18205143 0,20408807 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 1,000 0,18488208 0,20713536 ! positive regulation of defense response GO:0031349 26 26 0,000 0,18555589 0,20776397 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,18555589 0,20763782 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 0,000 0,18555589 0,20751183 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,18555589 0,20738599 ! induction of apoptosis by intracellular signals GO:0008629 26 26 0,000 0,18555589 0,2072603 ! cellular defense response GO:0006968 26 26 0,000 0,18555589 0,20713477 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,18555589 0,20700938 ! double-strand break repair GO:0006302 27 26 0,000 0,18555589 0,20688415 ! regulation of protein secretion GO:0050708 26 26 0,000 0,18555589 0,20675907 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,18555589 0,20663414 GO:0035150|regulation of tube size, ! maintenance of location in cell GO:0051651 27 26 0,000 0,18555589 0,20650936 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,19197257 0,2135217 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,19197257 0,21339292 ! cAMP-mediated signaling GO:0019933 27 27 0,000 0,19197257 0,21326429 ! peptide metabolic process GO:0006518 29 27 0,000 0,19197257 0,21313582 ! activation of caspase activity GO:0006919 27 27 0,000 0,19197257 0,2130075 ! defense response to bacterium GO:0042742 27 27 0,000 0,19197257 0,21287933 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,19197257 0,21275133 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,19197257 0,21262347 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,19833964 0,21954351 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! carbohydrate transport GO:0008643 28 28 0,000 0,19833964 0,21941174 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,19833964 0,21928011 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,19833964 0,21914865 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,19833964 0,21901735 ! cartilage development GO:0051216 29 28 0,000 0,19833964 0,2188862 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,20465745 0,22572333 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,20465745 0,22558833 ! leukocyte migration GO:0050900 30 29 0,000 0,20465745 0,22545349 ! antigen processing and presentation GO:0019882 29 29 0,000 0,20465745 0,22531881 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,20465745 0,22518429 ! tRNA processing GO:0008033 29 29 0,000 0,20465745 0,22504993 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,20465745 0,22491573 ! adult behavior GO:0030534 30 29 0,000 0,20465745 0,22478169 ! transition metal ion transport GO:0000041 31 30 0,000 0,21092639 0,23152909 ! RNA catabolic process GO:0006401 30 30 0,000 0,21092639 0,23139127 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,21092639 0,23125362 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,21092639 0,23111613 GO:0043280|positive regulation of caspase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,21092639 0,23097881 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,21092639 0,23084165 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,21092639 0,23070465 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,21092639 0,23056781 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,21092639 0,23043114 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,21092639 0,23029463 GO:0019724|B cell mediated immunity, ! regulation of inflammatory response GO:0050727 30 30 0,000 0,21092639 0,23015828 ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,21092639 0,23002209 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,21092639 0,22988606 ! regulation of translational initiation GO:0006446 31 31 0,000 0,21714682 0,23652577 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,21714682 0,23638606 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,21714682 0,23624651 ! ion transmembrane transport GO:0034220 31 31 0,000 0,21714682 0,23610714 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,21714682 0,23596792 ! digestion GO:0007586 31 31 0,000 0,21714682 0,23582887 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,21714682 0,23568999 ! regulation of heart contraction GO:0008016 31 31 0,000 0,21714682 0,23555126 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,21714682 0,2354127 ! camera-type eye development GO:0043010 31 31 0,000 0,21714682 0,23527431 ! extracellular matrix organization GO:0030198 31 31 0,000 0,21714682 0,23513607 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,21714682 0,234998 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,21714682 0,23486009 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,21714682 0,23472234 ! cell redox homeostasis GO:0045454 32 32 0,000 0,22331912 0,24125272 ! lipid modification GO:0030258 32 32 0,000 0,22331912 0,24111139 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,22331912 0,24097022 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,22331912 0,24082922 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,22331912 0,24068839 ! maintenance of location GO:0051235 33 32 0,000 0,22331912 0,24054772 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,22944365 0,24700038 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,22944365 0,24685619 ! muscle cell differentiation GO:0042692 35 34 0,000 0,23552077 0,25324666 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,23552077 0,253099 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,23552077 0,2529515 ! acute inflammatory response GO:0002526 35 35 0,000 0,24155084 0,25927676 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,24155084 0,25912585 ! hydrogen transport GO:0006818 36 36 0,000 0,24753423 0,2653901 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,24753423 0,2652358 ! regulation of mitosis GO:0007088 37 36 0,000 0,24753423 0,26508168 GO:0051783|regulation of nuclear division, ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,24753423 0,26492775 GO:0035113|embryonic appendage morphogenesis, ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,24753423 0,26477399 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,24753423 0,2646204 ! coagulation GO:0050817 39 36 0,000 0,24753423 0,264467 GO:0007596|blood coagulation, ! meiosis GO:0007126 37 37 0,000 0,25347127 0,27065328 GO:0051327|M phase of meiotic cell cycle, ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,25347127 0,27049656 ! eye development GO:0001654 37 37 0,000 0,25347127 0,27034002 ! DNA damage response, signal transduction GO:0042770 37 37 0,000 0,25347127 0,27018366 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,25347127 0,27002749 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,25347127 0,26987149 ! positive regulation of secretion GO:0051047 39 38 0,000 0,25936234 0,27598429 ! neurotransmitter transport GO:0006836 40 38 0,000 0,25936234 0,27582504 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,25936234 0,27566597 ! exocytosis GO:0006887 40 38 0,000 0,25936234 0,27550708 ! chromosome segregation GO:0007059 38 38 0,000 0,25936234 0,27534838 ! RNA elongation GO:0006354 38 38 0,000 0,25936234 0,27518986 ! meiotic cell cycle GO:0051321 38 38 0,000 0,25936234 0,27503152 ! hemostasis GO:0007599 42 39 0,000 0,26520777 0,28106838 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,26520777 0,28090685 ! response to unfolded protein GO:0006986 39 39 0,000 0,26520777 0,2807455 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,26520777 0,28058434 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,26520777 0,28042336 ! nucleotide-excision repair GO:0006289 40 39 0,000 0,26520777 0,28026257 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,26520777 0,28010196 ! limb development GO:0060173 39 39 0,000 0,26520777 0,27994153 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! cell cycle checkpoint GO:0000075 42 41 0,000 0,27676311 0,29197162 ! amine catabolic process GO:0009310 42 41 0,000 0,27676311 0,29180458 ! regulation of caspase activity GO:0043281 41 41 0,000 0,27676311 0,29163774 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,27676311 0,29147109 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,27676311 0,29130463 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,27676311 0,29113836 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,28247371 0,29697607 ! regulation of endopeptidase activity GO:0052548 42 42 0,000 0,28247371 0,29680676 ! protein ubiquitination GO:0016567 43 42 0,000 0,28247371 0,29663764 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,28247371 0,29646871 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! one-carbon metabolic process GO:0006730 42 42 0,000 0,28247371 0,29629997 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 0,000 0,28814005 0,30207174 ! mRNA transport GO:0051028 44 44 0,000 0,29376246 0,30779091 ! protein import into nucleus GO:0006606 44 44 0,000 0,29376246 0,30761603 ! negative regulation of organelle organization GO:0010639 45 44 0,000 0,29376246 0,30744135 ! vitamin metabolic process GO:0006766 44 44 0,000 0,29376246 0,30726687 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,29934128 0,31292455 ! nuclear import GO:0051170 45 45 0,000 0,29934128 0,31274716 ! protein processing GO:0016485 45 45 0,000 0,29934128 0,31256996 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 0,000 0,30487685 0,31816989 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,30487685 0,31798983 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,31036948 0,32353561 ! regulation of blood pressure GO:0008217 48 47 0,000 0,31036948 0,32335271 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,31581951 0,32884483 ! protein localization in nucleus GO:0034504 48 48 0,000 0,31581951 0,32865915 ! DNA recombination GO:0006310 48 48 0,000 0,31581951 0,32847368 ! cell cycle arrest GO:0007050 49 49 0,000 0,32122726 0,33390967 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,32122726 0,33372144 ! response to bacterium GO:0009617 50 49 0,000 0,32122726 0,33353343 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,32122726 0,33334563 ! regulation of defense response GO:0031347 50 50 0,000 0,32659305 0,33872312 ! negative regulation of transport GO:0051051 51 50 0,000 0,32659305 0,33853262 ! chromatin assembly GO:0031497 50 50 0,000 0,32659305 0,33834232 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,32659305 0,33815224 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 0,000 0,32659305 0,33796238 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,32659305 0,33777272 ! transcription initiation GO:0006352 50 50 0,000 0,32659305 0,33758328 ! protein modification by small protein conjugation GO:0032446 52 51 0,000 0,3319172 0,34289429 ! rRNA metabolic process GO:0016072 51 51 0,000 0,3319172 0,34270219 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,3319172 0,34251031 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,3319172 0,34231864 ! protein maturation GO:0051604 51 51 0,000 0,3319172 0,34212719 ! RNA localization GO:0006403 52 52 0,000 0,33720004 0,34737824 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,33720004 0,34718417 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 0,000 0,33720004 0,34699032 ! regulation of body fluid levels GO:0050878 55 52 0,000 0,33720004 0,34679669 ! sodium ion transport GO:0006814 53 53 0,000 0,34244187 0,35199128 ! tRNA metabolic process GO:0006399 53 53 0,000 0,34244187 0,35179507 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,34244187 0,35159909 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,34244187 0,35140332 ! hormone metabolic process GO:0042445 55 54 0,000 0,347643 0,35654204 ! sulfur metabolic process GO:0006790 55 54 0,000 0,347643 0,35634374 ! nucleosome organization GO:0034728 55 55 0,000 0,35280375 0,36143263 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,35280375 0,36123184 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 55 55 0,000 0,35280375 0,36103127 ! in utero embryonic development GO:0001701 55 55 0,000 0,35280375 0,36083092 ! protein modification by small protein conjugation or removal GO:0070647 56 55 0,000 0,35280375 0,36063079 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,35792442 0,36566226 ! ATP metabolic process GO:0046034 57 57 0,000 0,36300533 0,37064754 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,36300533 0,37044231 ! innate immune response GO:0045087 58 58 0,000 0,36804676 0,37537918 ! sterol metabolic process GO:0016125 59 59 0,000 0,37304903 0,38027066 ! protein localization in organelle GO:0033365 59 59 0,000 0,37304903 0,38006045 ! potassium ion transport GO:0006813 60 60 0,000 0,37801243 0,38490437 ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,38293726 0,38970368 GO:0016054|organic acid catabolic process, ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,38782381 0,39445876 ! protein import GO:0017038 62 62 0,000 0,38782381 0,39424119 ! regulation of secretion GO:0051046 65 63 0,000 0,39267237 0,39894994 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,39267237 0,39873013 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,39267237 0,39851056 ! regulation of hormone levels GO:0010817 66 65 0,000 0,4022567 0,40801271 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,40699304 0,41258975 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,40699304 0,41236293 ! DNA packaging GO:0006323 66 66 0,000 0,40699304 0,41213636 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,41169254 0,41666631 ! muscle contraction GO:0006936 67 67 0,000 0,41169254 0,41643762 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,41635548 0,42092328 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,41635548 0,42069251 ! sensory perception of sound GO:0007605 71 69 0,000 0,42098214 0,42513429 GO:0050954|sensory perception of mechanical stimulus, ! translational elongation GO:0006414 71 71 0,000 0,43012772 0,4341322 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,43012772 0,43389458 ! ribosome biogenesis GO:0042254 71 71 0,000 0,43012772 0,43365722 ! secretion by cell GO:0032940 75 72 0,000 0,4346472 0,43797418 ! muscle system process GO:0003012 72 72 0,000 0,4346472 0,43773485 ! regulation of cytokine production GO:0001817 72 72 0,000 0,4346472 0,43749579 ! electron transport chain GO:0022900 75 74 0,000 0,44358086 0,44624428 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,44799559 0,45043965 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,44799559 0,45019404 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,4695587 0,47160582 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,48209742 0,48393549 ! ncRNA processing GO:0034470 83 83 0,000 0,48209742 0,48367205 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,49434512 0,49568991 GO:0006644|phospholipid metabolic process, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,50235184 0,50344451 ! DNA replication GO:0006260 91 91 0,000 0,51412914 0,5149674 ! visual perception GO:0007601 93 92 0,000 0,51799378 0,51855651 GO:0050953|sensory perception of light stimulus, ! fatty acid metabolic process GO:0006631 93 92 0,000 0,51799378 0,51827499 ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,54055597 0,54055597