pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6693-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! polyol catabolic process GO:0046174 7 5 3,000 1,451E-08 3,338E-05 GO:0019405|alditol catabolic process, ! B cell lineage commitment GO:0002326 17 7 3,000 1,004E-07 1,155E-04 ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 2,456E-07 1,883E-04 ! interphase GO:0051325 159 88 7,000 2,939E-07 1,69E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 7,326E-07 3,37E-04 ! cellular carbohydrate catabolic process GO:0044275 13 11 3,000 9,253E-07 3,547E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 2,061E-06 6,773E-04 ! hexose biosynthetic process GO:0019319 35 29 4,000 2,166E-06 6,227E-04 ! cell cycle arrest GO:0007050 150 86 6,000 3,526E-06 9,012E-04 ! monosaccharide biosynthetic process GO:0046364 38 32 4,000 3,608E-06 8,298E-04 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 2,000 3,975E-06 8,311E-04 ! negative regulation of DNA binding GO:0043392 54 33 4,000 4,227E-06 8,101E-04 ! androgen receptor signaling pathway GO:0030521 54 33 4,000 4,227E-06 7,478E-04 ! G1 phase GO:0051318 27 16 3,000 4,958E-06 8,145E-04 ! negative regulation of binding GO:0051100 58 36 4,000 6,595E-06 1,011E-03 ! cytokinesis during cell cycle GO:0033205 9 6 2,000 7,906E-06 1,136E-03 ! alcohol biosynthetic process GO:0046165 45 38 4,000 8,677E-06 1,174E-03 ! alditol metabolic process GO:0019400 24 20 3,000 1,29E-05 1,648E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 2,19E-05 2,651E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 2,19E-05 2,518E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,19E-05 2,398E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,19E-05 2,289E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,19E-05 2,19E-03 ! response to UV GO:0009411 75 46 4,000 2,259E-05 2,165E-03 ! DNA ligation GO:0006266 14 9 2,000 3,267E-05 3,005E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 5,000 4,072E-05 3,603E-03 ! negative regulation of transcription regulator activity GO:0090048 47 27 3,000 4,487E-05 3,822E-03 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 3,000 4,487E-05 3,686E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 4,641E-05 3,681E-03 ! cytoplasmic sequestering of protein GO:0051220 14 10 2,000 4,641E-05 3,558E-03 ! actin cytoskeleton reorganization GO:0031532 21 11 2,000 6,347E-05 4,709E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 6,347E-05 4,562E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 6,465E-05 4,506E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 7,033E-05 4,758E-03 ! steroid hormone receptor signaling pathway GO:0030518 96 58 4,000 7,033E-05 4,622E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 8,97E-05 5,731E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 9,699E-05 6,029E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 4,000 1,047E-04 6,339E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 1,129E-04 6,66E-03 ! polyol metabolic process GO:0019751 44 34 3,000 1,139E-04 6,549E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 1,278E-04 7,172E-03 ! G1 phase of mitotic cell cycle GO:0000080 23 14 2,000 1,377E-04 7,543E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 1,712E-04 9,16E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,712E-04 8,952E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! fructose metabolic process GO:0006000 20 16 2,000 2,096E-04 0,01071413 ! B cell differentiation GO:0030183 62 40 3,000 2,168E-04 0,01084139 ! negative regulation of growth GO:0045926 123 75 4,000 2,395E-04 0,01172018 ! negative regulation of protein catabolic process GO:0042177 26 17 2,000 2,532E-04 0,0121307 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 2,532E-04 0,01188313 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 2,625E-04 0,01207629 ! regulation of DNA binding GO:0051101 119 77 4,000 2,709E-04 0,01221887 ! carbohydrate biosynthetic process GO:0016051 97 77 4,000 2,709E-04 0,01198389 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 3,021E-04 0,01311203 ! activation of JUN kinase activity GO:0007257 23 18 2,000 3,021E-04 0,01286922 ! negative regulation of T cell activation GO:0050868 25 18 2,000 3,021E-04 0,01263523 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 3,148E-04 0,01292787 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 3,569E-04 0,01439936 ! apoptotic nuclear changes GO:0030262 24 19 2,000 3,569E-04 0,01415109 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 4,065E-04 0,01584733 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 3,000 4,409E-04 0,01690268 ! regulation of intracellular transport GO:0032386 78 49 3,000 4,774E-04 0,01799993 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 2,000 4,845E-04 0,01797353 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 4,845E-04 0,01768823 ! gluconeogenesis GO:0006094 25 21 2,000 4,845E-04 0,01741185 ! cell aging GO:0007569 32 21 2,000 4,845E-04 0,01714398 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 4,845E-04 0,01688422 ! regulation of neurogenesis GO:0050767 153 89 4,000 5,302E-04 0,01820037 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,408E-04 0,01829036 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,408E-04 0,01802528 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 5,408E-04 0,01776778 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 5,408E-04 0,01751753 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 5,408E-04 0,01727423 ! valine metabolic process GO:0006573 8 5 1,000 5,408E-04 0,0170376 ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,408E-04 0,01680736 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 5,408E-04 0,01658326 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 5,408E-04 0,01636506 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 6 5 1,000 5,408E-04 0,01615253 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 5,408E-04 0,01594544 ! regulation of protein catabolic process GO:0042176 77 51 3,000 5,566E-04 0,01620618 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 2,000 5,58E-04 0,0160415 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 5,58E-04 0,01584345 ! positive regulation of JUN kinase activity GO:0043507 28 22 2,000 5,58E-04 0,01565024 ! aging GO:0007568 79 52 3,000 5,996E-04 0,01661513 ! cell fate commitment GO:0045165 141 92 4,000 6,171E-04 0,01689703 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 2,000 6,382E-04 0,01726853 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 6,382E-04 0,01706773 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 6,382E-04 0,01687155 ! negative regulation of catabolic process GO:0009895 34 23 2,000 6,382E-04 0,01667983 ! regulation of binding GO:0051098 151 95 4,000 7,143E-04 0,01845959 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 7,254E-04 0,01853813 ! pyruvate metabolic process GO:0006090 29 24 2,000 7,254E-04 0,01833442 ! sperm motility GO:0030317 27 24 2,000 7,254E-04 0,01813513 ! negative regulation of cell development GO:0010721 56 24 2,000 7,254E-04 0,01794013 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 2,000 7,254E-04 0,01774928 ! regulation of JUN kinase activity GO:0043506 34 24 2,000 7,254E-04 0,01756244 ! response to light stimulus GO:0009416 153 96 4,000 7,491E-04 0,01794757 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 4,000 7,852E-04 0,01861764 ! regulation of helicase activity GO:0051095 11 6 1,000 8,072E-04 0,01894413 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 8,072E-04 0,01875278 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 8,072E-04 0,01856525 ! mRNA stabilization GO:0048255 15 6 1,000 8,072E-04 0,01838144 GO:0043489|RNA stabilization, ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 8,072E-04 0,01820123 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 8,072E-04 0,01802451 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 8,072E-04 0,0178512 ! activation of MAPKKK activity GO:0000185 10 6 1,000 8,072E-04 0,01768119 ! ER overload response GO:0006983 7 6 1,000 8,072E-04 0,01751439 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 8,072E-04 0,0173507 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 8,072E-04 0,01719005 ! positive regulation of cytokine production during immune response GO:0002720 8 6 1,000 8,072E-04 0,01703234 ! DNA topological change GO:0006265 8 6 1,000 8,072E-04 0,0168775 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 8,072E-04 0,01672545 ! negative regulation of B cell activation GO:0050869 9 6 1,000 8,072E-04 0,01657612 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 8,072E-04 0,01642942 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 8,199E-04 0,01654109 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 8,199E-04 0,01639725 ! activation of MAPK activity GO:0000187 84 59 3,000 9,684E-04 0,0192011 ! response to ionizing radiation GO:0010212 47 27 2,000 1,031E-03 0,02027541 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,031E-03 0,02010359 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,125E-03 0,02173509 ! glycerol-3-phosphate metabolic process GO:0006072 9 7 1,000 1,125E-03 0,02155396 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,125E-03 0,02137583 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,125E-03 0,02120062 ! microtubule bundle formation GO:0001578 8 7 1,000 1,125E-03 0,02102826 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,125E-03 0,02085867 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,125E-03 0,0206918 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 1,000 1,125E-03 0,02052758 ! mast cell activation GO:0045576 9 7 1,000 1,125E-03 0,02036595 ! multicellular organismal aging GO:0010259 11 7 1,000 1,125E-03 0,02020684 ! T cell lineage commitment GO:0002360 12 7 1,000 1,125E-03 0,0200502 ! response to tumor cell GO:0002347 12 7 1,000 1,125E-03 0,01989597 ! neuroblast proliferation GO:0007405 13 7 1,000 1,125E-03 0,01974409 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 2,000 1,149E-03 0,02001913 ! regulation of B cell activation GO:0050864 42 28 2,000 1,149E-03 0,01986861 ! regulation of transcription factor activity GO:0051090 97 63 3,000 1,239E-03 0,02126269 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,239E-03 0,02110519 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,275E-03 0,02155515 ! cell cycle checkpoint GO:0000075 108 64 3,000 1,314E-03 0,02205717 ! B cell activation GO:0042113 104 65 3,000 1,392E-03 0,02320031 ! positive regulation of neurogenesis GO:0050769 45 30 2,000 1,409E-03 0,02330665 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,409E-03 0,02314017 ! DNA synthesis during DNA repair GO:0000731 9 8 1,000 1,492E-03 0,02433934 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,492E-03 0,02416794 ! induction of positive chemotaxis GO:0050930 14 8 1,000 1,492E-03 0,02399893 ! succinate metabolic process GO:0006105 14 8 1,000 1,492E-03 0,02383227 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,492E-03 0,02366791 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,492E-03 0,0235058 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,492E-03 0,0233459 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,492E-03 0,02318815 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,492E-03 0,02303253 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,492E-03 0,02287898 ! maintenance of protein location in cell GO:0032507 60 31 2,000 1,551E-03 0,02362485 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 2,000 1,702E-03 0,02575747 ! regulation of protein stability GO:0031647 48 32 2,000 1,702E-03 0,02558912 ! activation of protein kinase activity GO:0032147 102 69 3,000 1,737E-03 0,02594686 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 1,832E-03 0,02718627 ! regulation of catabolic process GO:0009894 106 70 3,000 1,832E-03 0,027012 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 1,862E-03 0,02728282 ! nucleus organization GO:0006997 49 33 2,000 1,862E-03 0,02711014 ! positive regulation of cell development GO:0010720 54 33 2,000 1,862E-03 0,02693964 ! cytokinesis GO:0000910 52 33 2,000 1,862E-03 0,02677126 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 1,909E-03 0,02727272 ! lung alveolus development GO:0048286 17 9 1,000 1,909E-03 0,02710437 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,909E-03 0,02693809 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,909E-03 0,02677383 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 1,000 1,909E-03 0,02661157 ! receptor clustering GO:0043113 15 9 1,000 1,909E-03 0,02645125 ! motor axon guidance GO:0008045 14 9 1,000 1,909E-03 0,02629286 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,909E-03 0,02613636 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,909E-03 0,02598171 ! pyrimidine base metabolic process GO:0006206 14 9 1,000 1,909E-03 0,02582887 ! localization within membrane GO:0051668 15 9 1,000 1,909E-03 0,02567783 ! lymphocyte differentiation GO:0030098 113 71 3,000 1,93E-03 0,0258142 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 2,000 2,032E-03 0,02700911 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 2,032E-03 0,02686484 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 3,000 2,138E-03 0,02809912 ! maintenance of protein location GO:0045185 65 35 2,000 2,21E-03 0,02888104 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,375E-03 0,03085847 ! regulation of cell projection assembly GO:0060491 20 10 1,000 2,375E-03 0,0306851 ! hippocampus development GO:0021766 19 10 1,000 2,375E-03 0,03051368 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,375E-03 0,03034416 ! blood vessel remodeling GO:0001974 21 10 1,000 2,375E-03 0,03017651 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,375E-03 0,03001071 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,375E-03 0,02984671 ! response to X-ray GO:0010165 16 10 1,000 2,375E-03 0,0296845 ! nucleobase biosynthetic process GO:0046112 21 10 1,000 2,375E-03 0,02952405 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,375E-03 0,02936531 ! regulation of bone resorption GO:0045124 24 10 1,000 2,375E-03 0,02920828 ! DNA methylation GO:0006306 15 10 1,000 2,375E-03 0,02905292 GO:0006305|DNA alkylation, ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,375E-03 0,0288992 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 2,375E-03 0,0287471 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 2,477E-03 0,02983242 ! regulation of protein transport GO:0051223 114 76 3,000 2,477E-03 0,02967705 GO:0070201|regulation of establishment of protein localization, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 2,000 2,595E-03 0,03093029 ! regulation of T cell proliferation GO:0042129 58 38 2,000 2,803E-03 0,03322833 ! maintenance of location in cell GO:0051651 69 38 2,000 2,803E-03 0,03305793 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 2,888E-03 0,03389426 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,888E-03 0,03372221 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 2,888E-03 0,03355189 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 2,888E-03 0,03338329 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 2,888E-03 0,03321637 ! negative regulation of proteolysis GO:0045861 16 11 1,000 2,888E-03 0,03305112 ! regulation of mRNA processing GO:0050684 18 11 1,000 2,888E-03 0,0328875 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,888E-03 0,03272549 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 2,888E-03 0,03256507 ! nitric oxide metabolic process GO:0046209 14 11 1,000 2,888E-03 0,03240622 GO:0006809|nitric oxide biosynthetic process, ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,888E-03 0,03224891 ! lysogeny GO:0030069 18 11 1,000 2,888E-03 0,03209312 GO:0019047|provirus integration, ! alcohol catabolic process GO:0046164 104 80 3,000 2,985E-03 0,03300938 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,02E-03 0,03323383 ! JNK cascade GO:0007254 54 39 2,000 3,02E-03 0,03307557 ! regulation of cell cycle process GO:0010564 122 81 3,000 3,122E-03 0,03403614 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 2,000 3,247E-03 0,03522931 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 3,247E-03 0,03506391 ! double-strand break repair GO:0006302 67 40 2,000 3,247E-03 0,03490006 ! JAK-STAT cascade GO:0007259 53 40 2,000 3,247E-03 0,03473773 ! ossification GO:0001503 134 82 3,000 3,264E-03 0,03475495 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 3,000 3,41E-03 0,03614021 ! non-recombinational repair GO:0000726 19 12 1,000 3,449E-03 0,03639089 GO:0006303|double-strand break repair via nonhomologous end joining, ! cartilage condensation GO:0001502 18 12 1,000 3,449E-03 0,03622472 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 3,449E-03 0,03606006 ! cell-cell junction assembly GO:0007043 18 12 1,000 3,449E-03 0,03589689 ! response to gamma radiation GO:0010332 20 12 1,000 3,449E-03 0,0357352 ! regulation of mRNA stability GO:0043488 27 12 1,000 3,449E-03 0,03557495 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 3,449E-03 0,03541613 ! regulation of T cell differentiation GO:0045580 59 41 2,000 3,485E-03 0,03562161 ! regulation of JNK cascade GO:0046328 58 41 2,000 3,485E-03 0,03546399 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 3,715E-03 0,03763633 ! regulation of protein localization GO:0032880 132 85 3,000 3,715E-03 0,03747126 ! regulation of JAK-STAT cascade GO:0046425 61 42 2,000 3,733E-03 0,03748883 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 2,000 3,733E-03 0,03732584 ! regulation of cell shape GO:0008360 78 42 2,000 3,733E-03 0,03716425 ! activation of caspase activity GO:0006919 65 43 2,000 3,991E-03 0,03956538 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 4,037E-03 0,03985335 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 4,057E-03 0,03987226 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 1,000 4,057E-03 0,03970259 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! bone mineralization GO:0030282 15 13 1,000 4,057E-03 0,03953436 ! regulation of cytokine production during immune response GO:0002718 18 13 1,000 4,057E-03 0,03936755 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 4,057E-03 0,03920214 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,057E-03 0,03903811 ! regulation of cellular pH GO:0030641 20 13 1,000 4,057E-03 0,03887545 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,057E-03 0,03871414 ! regulation of RNA stability GO:0043487 28 13 1,000 4,057E-03 0,03855417 ! regulation of cell projection organization GO:0031344 83 44 2,000 4,26E-03 0,04032034 ! regulation of T cell activation GO:0050863 128 89 3,000 4,379E-03 0,04127333 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 4,54E-03 0,04261737 ! leukocyte differentiation GO:0002521 143 90 3,000 4,556E-03 0,04259917 ! neuron maturation GO:0042551 21 14 1,000 4,71E-03 0,04385556 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,71E-03 0,04367873 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,71E-03 0,04350331 ! limbic system development GO:0021761 25 14 1,000 4,71E-03 0,0433293 ! activation of MAPKK activity GO:0000186 21 14 1,000 4,71E-03 0,04315667 ! cellular response to starvation GO:0009267 21 14 1,000 4,71E-03 0,04298541 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,71E-03 0,04281551 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 4,71E-03 0,04264694 ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,71E-03 0,0424797 ! positive regulation of axonogenesis GO:0050772 19 14 1,000 4,71E-03 0,04231377 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 4,71E-03 0,04214912 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 1,000 4,71E-03 0,04198575 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 4,71E-03 0,04182364 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 4,71E-03 0,04166278 ! DNA recombination GO:0006310 146 92 3,000 4,926E-03 0,04341008 ! carbohydrate catabolic process GO:0016052 121 93 3,000 5,118E-03 0,04493216 ! negative regulation of immune system process GO:0002683 73 47 2,000 5,132E-03 0,04487993 ! response to oxidative stress GO:0006979 141 94 3,000 5,316E-03 0,04631005 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 5,408E-03 0,04693675 ! lipid phosphorylation GO:0046834 23 15 1,000 5,408E-03 0,0467603 ! myoblast differentiation GO:0045445 27 15 1,000 5,408E-03 0,04658517 ! DNA integration GO:0015074 22 15 1,000 5,408E-03 0,04641134 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 5,408E-03 0,04623881 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 5,408E-03 0,04606755 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,408E-03 0,04589756 ! biomineral formation GO:0031214 18 15 1,000 5,408E-03 0,04572882 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,408E-03 0,04556132 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 5,408E-03 0,04539503 ! positive regulation of caspase activity GO:0043280 72 48 2,000 5,445E-03 0,04553711 GO:0010952|positive regulation of peptidase activity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 5,445E-03 0,04537212 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 5,445E-03 0,04520832 ! maintenance of location GO:0051235 84 49 2,000 5,769E-03 0,04772588 ! skeletal muscle fiber development GO:0048741 73 50 2,000 6,104E-03 0,05031875 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 6,151E-03 0,05052234 ! muscle fiber development GO:0048747 74 51 2,000 6,451E-03 0,05279839 ! positive regulation of cell migration GO:0030335 92 51 2,000 6,451E-03 0,05261116 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 6,937E-03 0,05637733 ! glycerol metabolic process GO:0006071 20 17 1,000 6,937E-03 0,05617882 ! signal complex assembly GO:0007172 29 17 1,000 6,937E-03 0,0559817 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 6,937E-03 0,05578596 ! forelimb morphogenesis GO:0035136 19 17 1,000 6,937E-03 0,05559159 ! regulation of viral genome replication GO:0045069 24 17 1,000 6,937E-03 0,05539856 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,937E-03 0,05520687 ! neuromuscular junction development GO:0007528 23 17 1,000 6,937E-03 0,0550165 ! nucleobase metabolic process GO:0009112 31 17 1,000 6,937E-03 0,05482744 ! cell-cell junction organization GO:0045216 25 17 1,000 6,937E-03 0,05463967 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 6,937E-03 0,05445319 ! regulation of mitosis GO:0007088 84 54 2,000 7,56E-03 0,05914435 GO:0051783|regulation of nuclear division, ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 7,766E-03 0,06055005 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 7,766E-03 0,06034549 ! axis specification GO:0009798 26 18 1,000 7,766E-03 0,06014231 ! pancreas development GO:0031016 26 18 1,000 7,766E-03 0,05994049 ! glutamine metabolic process GO:0006541 23 18 1,000 7,766E-03 0,05974002 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 7,766E-03 0,05954089 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,766E-03 0,05934308 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 7,766E-03 0,05914658 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 7,766E-03 0,05895137 ! positive regulation of cell motion GO:0051272 99 56 2,000 8,359E-03 0,06324029 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 8,638E-03 0,06513819 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 8,638E-03 0,06492532 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 8,638E-03 0,06471384 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 8,638E-03 0,06450373 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 8,638E-03 0,06429498 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 1,000 8,638E-03 0,06408758 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 8,638E-03 0,06388151 ! protein stabilization GO:0050821 26 19 1,000 8,638E-03 0,06367676 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 8,638E-03 0,06347332 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 8,638E-03 0,06327117 ! response to starvation GO:0042594 30 19 1,000 8,638E-03 0,06307031 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 8,638E-03 0,06287072 ! hindlimb morphogenesis GO:0035137 32 20 1,000 9,551E-03 0,06929937 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 9,551E-03 0,06908145 ! chromosome condensation GO:0030261 31 20 1,000 9,551E-03 0,0688649 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 9,551E-03 0,06864969 ! pallium development GO:0021543 38 20 1,000 9,551E-03 0,06843583 ! DNA modification GO:0006304 28 20 1,000 9,551E-03 0,0682233 ! positive regulation of locomotion GO:0040017 35 20 1,000 9,551E-03 0,06801208 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 31 20 1,000 9,551E-03 0,06780217 ! actin filament-based movement GO:0030048 34 20 1,000 9,551E-03 0,06759354 ! actin filament organization GO:0007015 95 59 2,000 9,646E-03 0,06805648 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 1,000 0,01050566 0,073893 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01050566 0,07366772 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01050566 0,0734438 ! dendrite development GO:0016358 35 21 1,000 0,01050566 0,07322125 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01050566 0,07300003 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01050566 0,07278016 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01050566 0,0725616 ! regulation of insulin secretion GO:0050796 26 21 1,000 0,01050566 0,07234435 ! platelet activation GO:0030168 28 21 1,000 0,01050566 0,07212839 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 0,01050566 0,07191372 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 0,01050566 0,07170033 ! regulation of cellular response to stress GO:0080135 85 61 2,000 0,01056528 0,07189393 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01150043 0,07802649 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01150043 0,077797 ! vasculogenesis GO:0001570 33 22 1,000 0,01150043 0,07756886 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01150043 0,07734205 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01150043 0,07711656 ! regulation of behavior GO:0050795 38 22 1,000 0,01150043 0,07689239 ! neural tube closure GO:0001843 33 22 1,000 0,01150043 0,07666951 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein tetramerization GO:0051262 39 22 1,000 0,01150043 0,07644792 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 0,01203599 0,07977747 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01253493 0,08284577 ! myelination GO:0042552 35 23 1,000 0,01253493 0,08260839 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,01253493 0,08237237 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01253493 0,08213769 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01253493 0,08190434 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01253493 0,08167232 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01253493 0,08144161 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01253493 0,08121219 ! somatic diversification of immune receptors GO:0002200 35 23 1,000 0,01253493 0,08098407 ! telomere organization GO:0032200 32 23 1,000 0,01253493 0,08075722 GO:0000723|telomere maintenance, ! liver development GO:0001889 40 23 1,000 0,01253493 0,08053164 ! regulation of caspase activity GO:0043281 97 65 2,000 0,01255102 0,08041045 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 0,01255102 0,08018709 ! protein oligomerization GO:0051259 100 65 2,000 0,01255102 0,07996497 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,01307853 0,08309563 ! initiation of viral infection GO:0019059 42 24 1,000 0,01360852 0,08622477 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,01360852 0,08598789 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01360852 0,08575231 ! fat cell differentiation GO:0045444 37 24 1,000 0,01360852 0,08551801 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01360852 0,08528499 ! receptor metabolic process GO:0043112 37 24 1,000 0,01360852 0,08505324 ! response to toxin GO:0009636 38 24 1,000 0,01360852 0,08482274 ! primary neural tube formation GO:0014020 35 24 1,000 0,01360852 0,08459349 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,01360852 0,08436548 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01360852 0,08413869 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01360852 0,08391312 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01361855 0,08375046 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01361855 0,08352713 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,01472058 0,09004607 ! regulation of peptide secretion GO:0002791 34 25 1,000 0,01472058 0,08980722 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01472058 0,08956964 ! response to drug GO:0042493 108 69 2,000 0,01473631 0,08942879 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01587047 0,09605813 ! regulation of pH GO:0006885 36 26 1,000 0,01587047 0,09580601 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01587047 0,09555521 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01587047 0,09530572 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01590456 0,09526171 ! muscle cell differentiation GO:0042692 104 71 2,000 0,01590456 0,09501428 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,0165077 0,09836195 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,0170576 0,10137592 ! mitochondrion organization GO:0007005 104 73 2,000 0,01712355 0,10150556 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 0,01775212 0,10496113 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,01775212 0,104692 ! cell junction assembly GO:0034329 56 28 1,000 0,01828134 0,10753732 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01828134 0,10726299 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01828134 0,10699006 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01828134 0,10671851 GO:0008366|axon ensheathment, ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,01828134 0,10644834 ! neural tube formation GO:0001841 41 28 1,000 0,01828134 0,10617953 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01828134 0,10591207 ! placenta development GO:0001890 37 28 1,000 0,01828134 0,10564596 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,01954111 0,11264297 ! telencephalon development GO:0021537 52 29 1,000 0,01954111 0,11236136 ! tissue homeostasis GO:0001894 42 29 1,000 0,01954111 0,11208116 GO:0048871|multicellular organismal homeostasis, ! protein ubiquitination GO:0016567 125 77 2,000 0,01971439 0,11279376 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,02039404 0,11639276 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02083629 0,11862244 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,02083629 0,11832955 ! response to heat GO:0009408 41 30 1,000 0,02083629 0,1180381 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,02083629 0,11774808 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02216631 0,12495713 ! mammary gland development GO:0030879 57 31 1,000 0,02216631 0,12465161 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,02216631 0,12434758 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02216631 0,12404503 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02216631 0,12374395 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,02250977 0,12535709 GO:0002696|positive regulation of leukocyte activation, ! regulation of muscle development GO:0048634 48 32 1,000 0,02353058 0,13072544 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,02353058 0,13041044 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02353058 0,13009696 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02353058 0,12978497 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02353058 0,12947448 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02492853 0,13683919 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! cell junction organization GO:0034330 63 33 1,000 0,02492853 0,13651338 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02492853 0,13618912 GO:0042593|glucose homeostasis, ! regulation of proteolysis GO:0030162 50 33 1,000 0,02492853 0,1358664 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02492853 0,1355452 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 1,000 0,02492853 0,13522552 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02635959 0,14265191 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,02635959 0,14231704 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02635959 0,14198375 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02635959 0,14165201 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02635959 0,14132182 ! neuron migration GO:0001764 46 34 1,000 0,02635959 0,14099316 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,02635959 0,14066603 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,02635959 0,14034042 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,02635959 0,1400163 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,02635959 0,13969369 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02708684 0,14321779 GO:0060538|skeletal muscle organ development, ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,0278232 0,14677377 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,0278232 0,1464379 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,0278232 0,14610357 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,02789442 0,14614386 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,0293188 0,15325739 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,0293188 0,15290987 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,0293188 0,15256392 ! tissue remodeling GO:0048771 62 36 1,000 0,0293188 0,15221953 ! neural tube development GO:0021915 50 36 1,000 0,0293188 0,15187669 ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,0293188 0,1515354 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,02954779 0,15237648 ! learning GO:0007612 67 37 1,000 0,03084585 0,15871468 ! amino acid activation GO:0043038 52 37 1,000 0,03084585 0,15836041 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,0324038 0,16598831 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,0324038 0,16561944 ! mesenchymal cell development GO:0014031 64 38 1,000 0,0324038 0,16525222 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! angiogenesis GO:0001525 149 95 2,000 0,03390327 0,17251665 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,03399212 0,17258693 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03399212 0,17220678 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03399212 0,17182831 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,03399212 0,17145149 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,03399212 0,17107632 ! cell growth GO:0016049 61 39 1,000 0,03399212 0,17070279 ! synapse organization GO:0050808 55 39 1,000 0,03399212 0,17033089 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,03481224 0,17406121 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03561027 0,17766514 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03561027 0,17728058 ! T cell differentiation GO:0030217 65 40 1,000 0,03561027 0,17689769 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03561027 0,17651644 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03561027 0,17613684 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03663635 0,1808232 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03663635 0,180436 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03663635 0,18005045 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03663635 0,17966655 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03663635 0,17928428 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03663635 0,17890363 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03663635 0,1785246 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03663635 0,17814717 ! sleep GO:0030431 11 5 0,000 0,03663635 0,17777133 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03663635 0,17739708 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03663635 0,17702439 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03663635 0,17665327 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03663635 0,17628371 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03663635 0,17591568 ! tongue development GO:0043586 6 5 0,000 0,03663635 0,17554919 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03663635 0,17518422 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03663635 0,17482077 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03663635 0,17445882 ! cobalt ion transport GO:0006824 9 5 0,000 0,03663635 0,17409837 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03663635 0,17373941 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03663635 0,17338192 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03663635 0,1730259 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03663635 0,17267134 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03663635 0,17231822 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03663635 0,17196655 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03663635 0,17161632 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03663635 0,1712675 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03663635 0,1709201 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03663635 0,17057411 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03663635 0,17022952 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03663635 0,16988631 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03663635 0,16954449 ! malate metabolic process GO:0006108 7 5 0,000 0,03663635 0,16920404 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03663635 0,16886495 ! behavioral response to pain GO:0048266 7 5 0,000 0,03663635 0,16852722 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03663635 0,16819084 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03663635 0,1678558 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03663635 0,16752209 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03663635 0,16718971 ! mating behavior GO:0007617 6 5 0,000 0,03663635 0,16685864 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03663635 0,16652888 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03663635 0,16620042 ! rhythmic behavior GO:0007622 12 5 0,000 0,03663635 0,16587325 ! copulation GO:0007620 7 5 0,000 0,03663635 0,16554737 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03663635 0,16522277 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03663635 0,16489944 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03663635 0,16457737 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03663635 0,16425655 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03663635 0,16393699 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03663635 0,16361866 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03663635 0,16330157 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03663635 0,16298571 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03663635 0,16267106 ! response to protozoan GO:0001562 9 5 0,000 0,03663635 0,16235763 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03663635 0,16204541 ! lymph vessel development GO:0001945 7 5 0,000 0,03663635 0,16173438 ! endochondral ossification GO:0001958 12 5 0,000 0,03663635 0,16142454 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03663635 0,16111589 ! parathyroid gland development GO:0060017 8 5 0,000 0,03663635 0,16080842 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03663635 0,16050212 ! anagen GO:0042640 6 5 0,000 0,03663635 0,16019698 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03663635 0,159893 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03663635 0,15959017 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03663635 0,15928849 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03663635 0,15898795 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03663635 0,15868853 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03663635 0,15839025 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03663635 0,15809308 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03663635 0,15779703 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03663635 0,15750208 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03663635 0,15720823 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03663635 0,15691548 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03663635 0,15662381 ! ovulation GO:0030728 6 5 0,000 0,03663635 0,15633323 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03663635 0,15604373 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03663635 0,15575529 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03663635 0,15546792 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03663635 0,15518161 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03663635 0,15489634 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03663635 0,15461213 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03663635 0,15432896 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03663635 0,15404682 ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03663635 0,15376571 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03663635 0,15348563 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03663635 0,15320657 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03663635 0,15292851 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03663635 0,15265147 ! urea metabolic process GO:0019627 6 5 0,000 0,03663635 0,15237543 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03663635 0,15210038 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03663635 0,15182633 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03663635 0,15155326 ! neutrophil activation GO:0042119 5 5 0,000 0,03663635 0,15128117 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03663635 0,15101006 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03663635 0,15073991 ! response to food GO:0032094 5 5 0,000 0,03663635 0,15047073 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03663635 0,15020252 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03663635 0,14993525 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03663635 0,14966894 ! forebrain neuron development GO:0021884 7 5 0,000 0,03663635 0,14940357 ! melanosome organization GO:0032438 7 5 0,000 0,03663635 0,14913914 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03663635 0,14887564 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03663635 0,14861307 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03663635 0,14835143 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03663635 0,14809071 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03663635 0,1478309 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03663635 0,147572 ! nucleoside transport GO:0015858 6 5 0,000 0,03663635 0,14731401 ! nucleoside salvage GO:0043174 7 5 0,000 0,03663635 0,14705691 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03663635 0,14680072 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03663635 0,14654541 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03663635 0,14629099 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03663635 0,14603746 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03663635 0,1457848 ! depyrimidination GO:0045008 8 5 0,000 0,03663635 0,14553301 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03663635 0,14528209 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03663635 0,14503203 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03663635 0,14478284 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03663635 0,1445345 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03663635 0,14428701 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03663635 0,14404036 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03663635 0,14379456 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03663635 0,14354959 ! monocyte differentiation GO:0030224 8 5 0,000 0,03663635 0,14330546 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03663635 0,14306216 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03663635 0,14281968 ! centrosome duplication GO:0051298 5 5 0,000 0,03663635 0,14257802 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03663635 0,14233718 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03663635 0,14209715 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03663635 0,14185793 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03663635 0,14161952 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03663635 0,1413819 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03663635 0,14114508 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03663635 0,14090905 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03663635 0,14067381 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03663635 0,14043935 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03663635 0,14020568 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03663635 0,13997278 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03663635 0,13974065 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03663635 0,13950929 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03663635 0,1392787 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03663635 0,13904886 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03663635 0,13881979 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03663635 0,13859147 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03663635 0,13836389 ! neural tube patterning GO:0021532 6 5 0,000 0,03663635 0,13813707 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03663635 0,13791098 ! histone demethylation GO:0016577 9 5 0,000 0,03663635 0,13768564 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03663635 0,13746103 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03663635 0,13723715 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03663635 0,137014 ! enteric nervous system development GO:0048484 8 5 0,000 0,03663635 0,13679158 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03663635 0,13656987 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03663635 0,13634889 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03663635 0,13612861 ! transcription termination GO:0006353 8 5 0,000 0,03663635 0,13590905 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03663635 0,1356902 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03663635 0,13547204 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03663635 0,13525459 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03663635 0,13503784 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03663635 0,13482178 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03663635 0,13460641 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03663635 0,13439173 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03663635 0,13417773 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03663635 0,13396441 ! apical protein localization GO:0045176 6 5 0,000 0,03663635 0,13375176 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03663635 0,1335398 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03663635 0,1333285 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03663635 0,13311787 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03663635 0,1329079 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03663635 0,1326986 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03663635 0,13248996 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03663635 0,13228196 ! glial cell migration GO:0008347 10 5 0,000 0,03663635 0,13207463 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03663635 0,13186794 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03663635 0,13166189 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03663635 0,13145649 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03663635 0,13125173 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03663635 0,13104761 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03663635 0,13084412 ! neural plate development GO:0001840 6 5 0,000 0,03663635 0,13064126 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03663635 0,13043903 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03663635 0,13023742 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03663635 0,13003644 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03663635 0,12983607 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03663635 0,12963633 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03663635 0,12943719 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03663635 0,12923867 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03663635 0,12904075 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03663635 0,12884344 ! spindle assembly GO:0051225 5 5 0,000 0,03663635 0,12864674 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03663635 0,12845063 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03663635 0,12825512 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03663635 0,1280602 ! organ regeneration GO:0031100 7 5 0,000 0,03663635 0,12786587 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03663635 0,12767214 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03663635 0,12747899 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03663635 0,12728642 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03663635 0,12709444 GO:0055081|anion homeostasis, ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03725774 0,12905542 ! endosome transport GO:0016197 71 41 1,000 0,03725774 0,12886135 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,03725774 0,12866786 ! biopolymer methylation GO:0043414 62 41 1,000 0,03725774 0,12847496 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,03761438 0,12951058 ! mitochondrial transport GO:0006839 60 42 1,000 0,038934 0,1338538 ! cellular component disassembly GO:0022411 64 42 1,000 0,038934 0,13365402 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,038934 0,13345483 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,04063853 0,13909022 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04063853 0,13888355 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,04063853 0,13867749 ! response to insulin stimulus GO:0032868 63 43 1,000 0,04063853 0,13847204 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,04063853 0,1382672 ! methylation GO:0032259 64 43 1,000 0,04063853 0,13806297 ! regulation of action potential GO:0001508 71 44 1,000 0,04237085 0,14373592 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,04237085 0,14352423 ! tRNA transcription GO:0009304 11 6 0,000 0,04380219 0,14815445 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04380219 0,1479369 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04380219 0,14771998 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04380219 0,1475037 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04380219 0,14728805 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04380219 0,14707303 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04380219 0,14685864 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04380219 0,14664487 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04380219 0,14643173 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04380219 0,1462192 ! prostate gland development GO:0030850 9 6 0,000 0,04380219 0,14600729 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04380219 0,14579599 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04380219 0,1455853 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04380219 0,14537522 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04380219 0,14516575 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04380219 0,14495688 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04380219 0,1447486 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04380219 0,14454093 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04380219 0,14433385 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,04380219 0,14412737 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04380219 0,14392147 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04380219 0,14371616 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04380219 0,14351144 ! signal peptide processing GO:0006465 8 6 0,000 0,04380219 0,1433073 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04380219 0,14310373 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04380219 0,14290075 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04380219 0,14269834 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04380219 0,1424965 ! opsonization GO:0008228 8 6 0,000 0,04380219 0,14229524 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04380219 0,14209454 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04380219 0,14189441 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04380219 0,14169484 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04380219 0,14149583 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04380219 0,14129738 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04380219 0,14109948 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04380219 0,14090214 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04380219 0,14070535 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04380219 0,14050911 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04380219 0,14031341 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04380219 0,14011826 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04380219 0,13992365 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04380219 0,13972958 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04380219 0,13953605 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04380219 0,13934306 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04380219 0,13915059 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04380219 0,13895866 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04380219 0,13876726 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04380219 0,13857638 ! thymic T cell selection GO:0045061 12 6 0,000 0,04380219 0,13838603 ! protein lipoylation GO:0009249 10 6 0,000 0,04380219 0,1381962 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04380219 0,13800689 ! pigment granule organization GO:0048753 11 6 0,000 0,04380219 0,1378181 ! drug transport GO:0015893 6 6 0,000 0,04380219 0,13762982 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04380219 0,13744206 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04380219 0,13725481 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04380219 0,13706807 ! histidine metabolic process GO:0006547 6 6 0,000 0,04380219 0,13688183 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04380219 0,1366961 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04380219 0,13651088 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04380219 0,13632616 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04380219 0,13614193 ! adenohypophysis development GO:0021984 10 6 0,000 0,04380219 0,1359582 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04380219 0,13577497 ! hyperosmotic response GO:0006972 8 6 0,000 0,04380219 0,13559223 ! microtubule nucleation GO:0007020 10 6 0,000 0,04380219 0,13540999 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04380219 0,13522823 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04380219 0,13504696 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04380219 0,13486617 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04380219 0,13468587 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04380219 0,13450605 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04380219 0,13432671 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04380219 0,13414784 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04380219 0,13396945 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04380219 0,13379154 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04380219 0,1336141 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04380219 0,13343712 ! neuron apoptosis GO:0051402 8 6 0,000 0,04380219 0,13326062 ! organic alcohol transport GO:0015850 9 6 0,000 0,04380219 0,13308458 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04380219 0,13290901 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04380219 0,1327339 ! male sex determination GO:0030238 9 6 0,000 0,04380219 0,13255925 ! carnitine transport GO:0015879 8 6 0,000 0,04380219 0,13238506 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04380219 0,13221132 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04380219 0,13203805 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04380219 0,13186522 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04380219 0,13169285 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04380219 0,13152093 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04380219 0,13134945 ! parturition GO:0007567 12 6 0,000 0,04380219 0,13117842 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04380219 0,13100784 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04380219 0,1308377 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04380219 0,130668 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04380219 0,13049874 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04380219 0,13032992 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04380219 0,13016154 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04380219 0,12999359 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04380219 0,12982607 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04380219 0,12965898 ! macrophage differentiation GO:0030225 10 6 0,000 0,04380219 0,12949233 ! astrocyte development GO:0014002 14 6 0,000 0,04380219 0,1293261 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04380219 0,12916029 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04380219 0,12899492 ! interaction with symbiont GO:0051702 8 6 0,000 0,04380219 0,12882996 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04380219 0,12866543 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04380219 0,12850131 ! eating behavior GO:0042755 6 6 0,000 0,04380219 0,12833762 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04380219 0,12817434 ! response to copper ion GO:0046688 9 6 0,000 0,04380219 0,12801147 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04380219 0,12784902 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04380219 0,12768698 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04380219 0,12752535 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04380219 0,12736413 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04380219 0,12720332 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04380219 0,12704291 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04380219 0,12688291 ! gas homeostasis GO:0033483 11 6 0,000 0,04380219 0,12672331 ! hair follicle maturation GO:0048820 7 6 0,000 0,04380219 0,12656411 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04380219 0,12640531 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04380219 0,1262469 ! Schwann cell development GO:0014044 14 6 0,000 0,04380219 0,1260889 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04380219 0,12593129 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04380219 0,12577407 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04380219 0,12561724 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04380219 0,12546081 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04380219 0,12530476 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04380219 0,1251491 ! histone ubiquitination GO:0016574 7 6 0,000 0,04380219 0,12499383 ! regulation of meiosis GO:0040020 10 6 0,000 0,04380219 0,12483895 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04380219 0,12468444 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04380219 0,12453032 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04380219 0,12437658 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04380219 0,12422322 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04380219 0,12407023 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04380219 0,12391762 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04380219 0,12376539 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04380219 0,12361353 ! receptor internalization GO:0031623 9 6 0,000 0,04380219 0,12346205 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04380219 0,12331093 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04380219 0,12316018 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04380219 0,1230098 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04380219 0,12285979 ! protein deubiquitination GO:0016579 8 6 0,000 0,04380219 0,12271014 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04380219 0,12256086 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04380219 0,12241194 ! axonal fasciculation GO:0007413 9 6 0,000 0,04380219 0,12226338 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04380219 0,12211519 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04380219 0,12196735 ! midbrain development GO:0030901 6 6 0,000 0,04380219 0,12181987 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04380219 0,12167274 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04380219 0,12152597 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04380219 0,12137955 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04380219 0,12123349 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04380219 0,12108778 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04380219 0,12094241 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04380219 0,1207974 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04380219 0,12065273 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04380219 0,12050841 ! adult feeding behavior GO:0008343 6 6 0,000 0,04380219 0,12036443 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04380219 0,1202208 ! blastocyst growth GO:0001832 15 6 0,000 0,04380219 0,12007751 ! pigment granule transport GO:0051904 12 6 0,000 0,04380219 0,11993456 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04380219 0,11979195 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04380219 0,11964968 ! catecholamine transport GO:0051937 7 6 0,000 0,04380219 0,11950774 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04380219 0,11936615 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04380219 0,11922489 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04380219 0,11908396 ! protein prenylation GO:0018342 10 6 0,000 0,04380219 0,11894336 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04380219 0,1188031 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04380219 0,11866317 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04380219 0,11852356 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04380219 0,11838429 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,04413044 0,11913147 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,04413044 0,1189918 ! cell maturation GO:0048469 60 45 1,000 0,04413044 0,11885247 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04591681 0,1235189 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,04591681 0,1233746 ! viral infectious cycle GO:0019058 71 47 1,000 0,04772947 0,12809543 ! glutamine family amino acid metabolic process GO:0009064 59 47 1,000 0,04772947 0,12794613 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04772947 0,12779718 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04956794 0,13256542 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04956794 0,13241146 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05091513 0,13585242 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05091513 0,135695 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05091513 0,13553795 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05091513 0,13538126 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05091513 0,13522493 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05091513 0,13506896 GO:0070193|synaptonemal complex organization, ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05091513 0,13491335 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05091513 0,1347581 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05091513 0,1346032 ! reproductive behavior GO:0019098 12 7 0,000 0,05091513 0,13444867 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05091513 0,13429448 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05091513 0,13414065 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,05091513 0,13398717 ! oligopeptide transport GO:0006857 11 7 0,000 0,05091513 0,13383404 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05091513 0,13368126 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05091513 0,13352883 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05091513 0,13337675 ! RNA methylation GO:0001510 11 7 0,000 0,05091513 0,13322501 ! pericardium development GO:0060039 8 7 0,000 0,05091513 0,13307362 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05091513 0,13292257 ! fibril organization GO:0043206 13 7 0,000 0,05091513 0,13277187 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05091513 0,1326215 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,05091513 0,13247148 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05091513 0,13232179 ! lipoprotein transport GO:0042953 9 7 0,000 0,05091513 0,13217245 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05091513 0,13202344 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05091513 0,13187476 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05091513 0,13172642 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05091513 0,13157841 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05091513 0,13143074 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05091513 0,13128339 ! chemosensory behavior GO:0007635 9 7 0,000 0,05091513 0,13113638 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05091513 0,1309897 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05091513 0,13084334 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05091513 0,13069731 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05091513 0,1305516 ! reflex GO:0060004 12 7 0,000 0,05091513 0,13040622 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05091513 0,13026117 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05091513 0,13011643 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05091513 0,12997202 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05091513 0,12982792 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05091513 0,12968415 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05091513 0,12954069 ! spinal cord patterning GO:0021511 7 7 0,000 0,05091513 0,12939756 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05091513 0,12925473 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05091513 0,12911222 ! adrenal gland development GO:0030325 17 7 0,000 0,05091513 0,12897003 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05091513 0,12882815 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05091513 0,12868658 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05091513 0,12854532 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05091513 0,12840437 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05091513 0,12826373 ! endosome organization GO:0007032 10 7 0,000 0,05091513 0,1281234 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05091513 0,12798337 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05091513 0,12784365 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05091513 0,12770424 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05091513 0,12756513 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05091513 0,12742632 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05091513 0,12728781 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05091513 0,12714961 ! galactose metabolic process GO:0006012 10 7 0,000 0,05091513 0,1270117 ! vesicle fusion GO:0006906 15 7 0,000 0,05091513 0,12687409 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05091513 0,12673678 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05091513 0,12659977 ! organ growth GO:0035265 11 7 0,000 0,05091513 0,12646305 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05091513 0,12632663 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05091513 0,1261905 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05091513 0,12605467 ! retinol metabolic process GO:0042572 9 7 0,000 0,05091513 0,12591913 ! behavioral fear response GO:0001662 13 7 0,000 0,05091513 0,12578388 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05091513 0,12564891 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05091513 0,12551424 ! rRNA modification GO:0000154 12 7 0,000 0,05091513 0,12537986 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05091513 0,12524576 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05091513 0,12511195 ! response to UV-B GO:0010224 11 7 0,000 0,05091513 0,12497843 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05091513 0,12484519 ! intermediate filament organization GO:0045109 11 7 0,000 0,05091513 0,12471223 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05091513 0,12457956 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05091513 0,12444717 ! fibrinolysis GO:0042730 9 7 0,000 0,05091513 0,12431506 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05091513 0,12418323 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05091513 0,12405168 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05091513 0,12392041 ! response to tropane GO:0014073 13 7 0,000 0,05091513 0,12378942 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05091513 0,1236587 ! melanosome localization GO:0032400 10 7 0,000 0,05091513 0,12352826 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05091513 0,12339809 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05091513 0,1232682 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05091513 0,12313858 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05091513 0,12300923 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05091513 0,12288016 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05091513 0,12275135 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05091513 0,12262281 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05091513 0,12249455 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05091513 0,12236655 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05091513 0,12223882 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05091513 0,12211135 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05091513 0,12198415 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05091513 0,12185722 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05091513 0,12173055 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05091513 0,12160414 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05091513 0,121478 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05091513 0,12135211 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05091513 0,12122649 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05091513 0,12110112 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05091513 0,12097602 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,05091513 0,12085117 ! diuresis GO:0030146 12 7 0,000 0,05091513 0,12072659 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05091513 0,12060225 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05091513 0,12047818 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05091513 0,12035436 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05091513 0,12023079 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05091513 0,12010747 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05091513 0,11998441 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05091513 0,1198616 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05091513 0,11973905 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05091513 0,11961674 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05091513 0,11949468 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05091513 0,11937287 ! lymph node development GO:0048535 9 7 0,000 0,05091513 0,11925131 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05091513 0,11913 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05091513 0,11900893 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05091513 0,11888811 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05091513 0,11876753 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05091513 0,1186472 ! ATP catabolic process GO:0006200 10 7 0,000 0,05091513 0,11852711 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05091513 0,11840727 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05091513 0,11828766 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05091513 0,1181683 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05091513 0,11804918 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05091513 0,1179303 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05091513 0,11781166 ! muscle adaptation GO:0043500 12 7 0,000 0,05091513 0,11769325 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05091513 0,11757509 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05091513 0,11745716 ! retina homeostasis GO:0001895 9 7 0,000 0,05091513 0,11733947 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05091513 0,11722201 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05091513 0,11710479 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05091513 0,1169878 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05091513 0,11687105 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05091513 0,11675452 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05091513 0,11663823 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05091513 0,11652218 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,05143174 0,11758748 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,05143174 0,11747071 ! cartilage development GO:0051216 70 49 1,000 0,05143174 0,11735417 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,0533204 0,12154304 ! lipid modification GO:0030258 73 50 1,000 0,0533204 0,1214227 ! positive regulation of growth GO:0045927 67 50 1,000 0,0533204 0,1213026 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,0533204 0,12118273 ! positive regulation of secretion GO:0051047 71 51 1,000 0,05523346 0,12540666 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05523346 0,12528299 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05717044 0,12954879 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,05717044 0,12942128 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05797556 0,13111483 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05797556 0,13098603 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05797556 0,13085749 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05797556 0,1307292 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05797556 0,13060116 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05797556 0,13047337 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05797556 0,13034583 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05797556 0,13021853 ! phosphate transport GO:0006817 10 8 0,000 0,05797556 0,13009149 ! N-glycan processing GO:0006491 12 8 0,000 0,05797556 0,1299647 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05797556 0,12983815 ! UTP metabolic process GO:0046051 8 8 0,000 0,05797556 0,12971185 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05797556 0,12958579 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05797556 0,12945998 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05797556 0,12933441 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05797556 0,12920909 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05797556 0,12908401 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,05797556 0,12895917 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05797556 0,12883457 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,05797556 0,12871021 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05797556 0,12858609 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05797556 0,12846222 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05797556 0,12833857 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05797556 0,12821517 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05797556 0,12809201 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05797556 0,12796908 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05797556 0,12784638 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05797556 0,12772393 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05797556 0,1276017 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05797556 0,12747971 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05797556 0,12735796 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05797556 0,12723643 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05797556 0,12711514 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05797556 0,12699408 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05797556 0,12687324 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05797556 0,12675264 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05797556 0,12663227 ! melanin metabolic process GO:0006582 12 8 0,000 0,05797556 0,12651212 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05797556 0,12639221 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05797556 0,12627252 ! macrophage activation GO:0042116 12 8 0,000 0,05797556 0,12615306 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05797556 0,12603382 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05797556 0,12591481 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05797556 0,12579602 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05797556 0,12567745 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05797556 0,12555911 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05797556 0,125441 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05797556 0,1253231 ! ruffle organization GO:0031529 11 8 0,000 0,05797556 0,12520543 ! osteoblast development GO:0002076 13 8 0,000 0,05797556 0,12508797 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05797556 0,12497074 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05797556 0,12485373 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05797556 0,12473693 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05797556 0,12462035 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05797556 0,124504 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05797556 0,12438785 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05797556 0,12427193 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05797556 0,12415622 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05797556 0,12404072 ! brain morphogenesis GO:0048854 20 8 0,000 0,05797556 0,12392545 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05797556 0,12381038 ! segment specification GO:0007379 10 8 0,000 0,05797556 0,12369553 ! cellular extravasation GO:0045123 11 8 0,000 0,05797556 0,12358089 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05797556 0,12346646 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05797556 0,12335225 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05797556 0,12323824 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05797556 0,12312445 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05797556 0,12301087 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05797556 0,12289749 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05797556 0,12278433 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05797556 0,12267137 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05797556 0,12255862 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05797556 0,12244608 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05797556 0,12233374 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05797556 0,12222161 ! icosanoid secretion GO:0032309 12 8 0,000 0,05797556 0,12210969 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05797556 0,12199797 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05797556 0,12188645 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05797556 0,12177514 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05797556 0,12166403 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05797556 0,12155313 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05797556 0,12144242 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05797556 0,12133192 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05797556 0,12122162 ! sterol catabolic process GO:0016127 9 8 0,000 0,05797556 0,12111152 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05797556 0,12100161 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05797556 0,12089191 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05797556 0,12078241 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05797556 0,1206731 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05797556 0,120564 ! prophase GO:0051324 11 8 0,000 0,05797556 0,12045509 ! S phase GO:0051320 8 8 0,000 0,05797556 0,12034637 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05797556 0,12023785 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05797556 0,12012953 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05797556 0,1200214 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05797556 0,11991347 ! hormone catabolic process GO:0042447 13 8 0,000 0,05797556 0,11980573 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05797556 0,11969819 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05797556 0,11959083 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05797556 0,11948367 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05797556 0,1193767 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05797556 0,11926993 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,05797556 0,11916334 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05797556 0,11905695 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05797556 0,11895074 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05797556 0,11884472 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05797556 0,1187389 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05797556 0,11863326 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05797556 0,1185278 ! regulation of embryonic development GO:0045995 16 8 0,000 0,05797556 0,11842254 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05797556 0,11831746 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05797556 0,11821257 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,0591309 0,12046154 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,0591309 0,12035494 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,06111439 0,12428214 ! DNA catabolic process GO:0006308 67 54 1,000 0,06111439 0,12417235 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,06111439 0,12406276 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,06111439 0,12395336 ! mesoderm development GO:0007498 76 55 1,000 0,06312046 0,12790931 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06498386 0,13156944 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06498386 0,13145373 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06498386 0,13133821 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06498386 0,1312229 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06498386 0,1311078 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06498386 0,13099289 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06498386 0,13087819 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06498386 0,13076368 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06498386 0,13064938 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06498386 0,13053527 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06498386 0,13042137 ! GTP metabolic process GO:0046039 9 9 0,000 0,06498386 0,13030766 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06498386 0,13019415 ! social behavior GO:0035176 14 9 0,000 0,06498386 0,13008084 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06498386 0,12996773 ! artery development GO:0060840 19 9 0,000 0,06498386 0,12985481 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06498386 0,12974209 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06498386 0,12962956 ! response to pain GO:0048265 16 9 0,000 0,06498386 0,12951723 ! protein complex disassembly GO:0043241 17 9 0,000 0,06498386 0,1294051 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06498386 0,12929316 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06498386 0,12918141 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06498386 0,12906985 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06498386 0,12895849 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06498386 0,12884732 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06498386 0,12873634 ! protein targeting to ER GO:0045047 19 9 0,000 0,06498386 0,12862555 ! T cell selection GO:0045058 18 9 0,000 0,06498386 0,12851495 ! endoderm development GO:0007492 12 9 0,000 0,06498386 0,12840454 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06498386 0,12829432 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06498386 0,1281843 ! arginine catabolic process GO:0006527 10 9 0,000 0,06498386 0,12807445 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06498386 0,1279648 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06498386 0,12785534 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06498386 0,12774606 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06498386 0,12763697 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06498386 0,12752806 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06498386 0,12741934 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06498386 0,12731081 ! mannose metabolic process GO:0006013 9 9 0,000 0,06498386 0,12720246 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06498386 0,12709429 ! epithelial cell development GO:0002064 10 9 0,000 0,06498386 0,12698631 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06498386 0,12687851 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06498386 0,1267709 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06498386 0,12666346 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06498386 0,12655621 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06498386 0,12644914 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06498386 0,12634226 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06498386 0,12623555 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06498386 0,12612902 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06498386 0,12602267 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06498386 0,1259165 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06498386 0,12581051 ! response to amine stimulus GO:0014075 13 9 0,000 0,06498386 0,1257047 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06498386 0,12559907 ! erythrocyte development GO:0048821 11 9 0,000 0,06498386 0,12549361 ! renal water homeostasis GO:0003091 14 9 0,000 0,06498386 0,12538833 ! postreplication repair GO:0006301 11 9 0,000 0,06498386 0,12528323 ! mRNA cleavage GO:0006379 13 9 0,000 0,06498386 0,1251783 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06498386 0,12507355 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06498386 0,12496897 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06498386 0,12486457 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06498386 0,12476034 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06498386 0,12465629 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06498386 0,12455241 ! acid secretion GO:0046717 14 9 0,000 0,06498386 0,1244487 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06498386 0,12434516 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06498386 0,1242418 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06498386 0,12413861 ! purine base metabolic process GO:0006144 18 9 0,000 0,06498386 0,12403559 ! oocyte differentiation GO:0009994 12 9 0,000 0,06498386 0,12393274 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,06498386 0,12383006 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06498386 0,12372756 ! spleen development GO:0048536 15 9 0,000 0,06498386 0,12362522 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06498386 0,12352305 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06498386 0,12342105 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06498386 0,12331921 ! detection of calcium ion GO:0005513 13 9 0,000 0,06498386 0,12321755 ! blastocyst formation GO:0001825 12 9 0,000 0,06498386 0,12311605 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06498386 0,12301472 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06498386 0,12291356 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06498386 0,12281256 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06498386 0,12271173 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06498386 0,12261106 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06498386 0,12251056 ! prepulse inhibition GO:0060134 14 9 0,000 0,06498386 0,12241023 ! embryonic placenta development GO:0001892 12 9 0,000 0,06498386 0,12231006 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06498386 0,12221005 ! insulin secretion GO:0030073 17 9 0,000 0,06498386 0,1221102 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06498386 0,12201052 ! response to nicotine GO:0035094 16 9 0,000 0,06498386 0,121911 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06498386 0,12181164 ! nucleus localization GO:0051647 15 9 0,000 0,06498386 0,12171245 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06498386 0,12161342 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,06514868 0,12182273 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,06514868 0,12172377 ! chromosome segregation GO:0007059 83 57 1,000 0,0671986 0,12545193 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,0671986 0,12535018 ! developmental maturation GO:0021700 75 57 1,000 0,0671986 0,1252486 ! viral reproductive process GO:0022415 87 58 1,000 0,0692698 0,12900448 ! lung development GO:0030324 94 59 1,000 0,07136185 0,13279309 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,07136185 0,13268574 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07194043 0,13365347 ! neuron fate specification GO:0048665 11 10 0,000 0,07194043 0,1335456 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07194043 0,1334379 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07194043 0,13333037 ! thyroid gland development GO:0030878 19 10 0,000 0,07194043 0,13322302 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07194043 0,13311584 ! synapsis GO:0007129 13 10 0,000 0,07194043 0,13300884 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07194043 0,132902 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07194043 0,13279534 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07194043 0,13268885 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07194043 0,13258253 ! sulfate transport GO:0008272 12 10 0,000 0,07194043 0,13247638 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07194043 0,13237039 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,07194043 0,13226458 ! phospholipid efflux GO:0033700 16 10 0,000 0,07194043 0,13215894 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07194043 0,13205347 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07194043 0,13194816 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07194043 0,13184302 ! pathogenesis GO:0009405 13 10 0,000 0,07194043 0,13173805 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07194043 0,13163325 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07194043 0,13152861 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07194043 0,13142414 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07194043 0,13131984 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07194043 0,1312157 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07194043 0,13111172 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07194043 0,13100791 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07194043 0,13090427 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07194043 0,13080078 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07194043 0,13069747 ! B cell proliferation GO:0042100 14 10 0,000 0,07194043 0,13059431 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07194043 0,13049132 ! forebrain cell migration GO:0021885 17 10 0,000 0,07194043 0,13038849 ! lipid digestion GO:0044241 15 10 0,000 0,07194043 0,13028582 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07194043 0,13018331 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07194043 0,13008097 ! UV protection GO:0009650 14 10 0,000 0,07194043 0,12997878 ! entry into host cell GO:0030260 20 10 0,000 0,07194043 0,12987676 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07194043 0,1297749 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07194043 0,12967319 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07194043 0,12957165 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07194043 0,12947026 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07194043 0,12936903 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07194043 0,12926796 ! regulation of organ growth GO:0046620 11 10 0,000 0,07194043 0,12916705 ! response to dsRNA GO:0043331 18 10 0,000 0,07194043 0,1290663 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07194043 0,1289657 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07194043 0,12886526 ! embryonic axis specification GO:0000578 12 10 0,000 0,07194043 0,12876497 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07194043 0,12866485 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07194043 0,12856487 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07194043 0,12846506 ! cranial nerve development GO:0021545 12 10 0,000 0,07194043 0,12836539 ! fucose catabolic process GO:0019317 16 10 0,000 0,07194043 0,12826589 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07194043 0,12816653 ! protein sumoylation GO:0016925 12 10 0,000 0,07194043 0,12806733 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07194043 0,12796829 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07194043 0,12786939 ! zymogen activation GO:0031638 14 10 0,000 0,07194043 0,12777065 ! salivary gland development GO:0007431 22 10 0,000 0,07194043 0,12767206 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07194043 0,12757363 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07194043 0,12747534 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07194043 0,12737721 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07194043 0,12727923 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07194043 0,12718139 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07194043 0,12708371 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07194043 0,12698618 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07194043 0,1268888 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07194043 0,12679157 ! detection of bacterium GO:0016045 10 10 0,000 0,07194043 0,12669448 ! embryonic gut development GO:0048566 11 10 0,000 0,07194043 0,12659755 ! activation of innate immune response GO:0002218 10 10 0,000 0,07194043 0,12650076 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07194043 0,12640412 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07194043 0,12630763 ! developmental induction GO:0031128 13 10 0,000 0,07194043 0,12621128 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07194043 0,12611509 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07194043 0,12601903 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07194043 0,12592313 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,07347434 0,12851025 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07347434 0,1284126 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,07347434 0,1283151 GO:0035113|embryonic appendage morphogenesis, ! regulation of homeostatic process GO:0032844 105 60 1,000 0,07347434 0,12821774 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,07560685 0,13183909 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,07560685 0,13173921 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,07560685 0,13163948 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! respiratory tube development GO:0030323 99 62 1,000 0,07775897 0,13528414 ! rRNA transcription GO:0009303 17 11 0,000 0,07884564 0,13707102 ! respiratory burst GO:0045730 14 11 0,000 0,07884564 0,1369675 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07884564 0,13686412 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07884564 0,13676091 ! virus-host interaction GO:0019048 17 11 0,000 0,07884564 0,13665785 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07884564 0,13655494 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,07884564 0,13645219 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07884564 0,1363496 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07884564 0,13624716 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,07884564 0,13614487 ! mating GO:0007618 14 11 0,000 0,07884564 0,13604273 ! T cell proliferation GO:0042098 20 11 0,000 0,07884564 0,13594075 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07884564 0,13583892 ! bone resorption GO:0045453 16 11 0,000 0,07884564 0,13573725 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07884564 0,13563573 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07884564 0,13553435 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07884564 0,13543313 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07884564 0,13533206 ! syncytium formation GO:0006949 15 11 0,000 0,07884564 0,13523114 ! plasma membrane organization GO:0007009 18 11 0,000 0,07884564 0,13513038 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07884564 0,13502976 ! focal adhesion formation GO:0048041 24 11 0,000 0,07884564 0,13492929 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07884564 0,13482897 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07884564 0,1347288 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07884564 0,13462878 ! adult heart development GO:0007512 11 11 0,000 0,07884564 0,13452891 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07884564 0,13442918 ! temperature homeostasis GO:0001659 16 11 0,000 0,07884564 0,1343296 ! L-glutamate transport GO:0015813 16 11 0,000 0,07884564 0,13423017 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07884564 0,13413089 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07884564 0,13403175 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07884564 0,13393277 ! stem cell development GO:0048864 29 11 0,000 0,07884564 0,13383392 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07884564 0,13373522 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07884564 0,13363667 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07884564 0,13353827 ! vasoconstriction GO:0042310 15 11 0,000 0,07884564 0,13344 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07884564 0,13334189 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07884564 0,13324391 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07884564 0,13314608 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07884564 0,1330484 ! ribosome assembly GO:0042255 13 11 0,000 0,07884564 0,13295085 ! histone deacetylation GO:0016575 13 11 0,000 0,07884564 0,13285345 ! chromatin silencing GO:0006342 19 11 0,000 0,07884564 0,1327562 ! nucleosome positioning GO:0016584 13 11 0,000 0,07884564 0,13265908 ! T cell homeostasis GO:0043029 20 11 0,000 0,07884564 0,13256211 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07884564 0,13246528 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07884564 0,13236859 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07884564 0,13227204 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07884564 0,13217563 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07884564 0,13207936 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07884564 0,13198323 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07884564 0,13188725 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07884564 0,1317914 ! male genitalia development GO:0030539 13 11 0,000 0,07884564 0,13169569 ! cholesterol efflux GO:0033344 19 11 0,000 0,07884564 0,13160012 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07884564 0,13150469 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07884564 0,13140939 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07884564 0,13131424 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07884564 0,13121922 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07884564 0,13112434 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07884564 0,1310296 ! defense response to fungus GO:0050832 12 11 0,000 0,07884564 0,13093499 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07884564 0,13084052 ! actin filament polymerization GO:0030041 17 11 0,000 0,07884564 0,13074619 ! acrosome reaction GO:0007340 13 11 0,000 0,07884564 0,13065199 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07884564 0,13055793 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,0799303 0,13225878 ! viral reproduction GO:0016032 92 63 1,000 0,0799303 0,13216369 ! regulation of lipase activity GO:0060191 109 63 1,000 0,0799303 0,13206875 ! appendage morphogenesis GO:0035107 93 64 1,000 0,08212044 0,13559011 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 1,000 0,08212044 0,13549284 ! adaptive immune response GO:0002250 94 64 1,000 0,08212044 0,13539571 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 1,000 0,084329 0,13893746 GO:0060173|limb development, ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,084329 0,138838 ! lactation GO:0007595 20 12 0,000 0,08569986 0,14099404 ! reproductive cellular process GO:0048610 14 12 0,000 0,08569986 0,14089326 ! tRNA modification GO:0006400 14 12 0,000 0,08569986 0,14079262 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08569986 0,14069213 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08569986 0,14059178 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08569986 0,14049157 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08569986 0,1403915 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08569986 0,14029158 ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08569986 0,1401918 ! peroxisomal transport GO:0043574 21 12 0,000 0,08569986 0,14009216 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08569986 0,13999266 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08569986 0,13989331 ! heart looping GO:0001947 15 12 0,000 0,08569986 0,13979409 ! palate development GO:0060021 15 12 0,000 0,08569986 0,13969502 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08569986 0,13959608 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08569986 0,13949729 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08569986 0,13939863 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08569986 0,13930012 ! arginine metabolic process GO:0006525 13 12 0,000 0,08569986 0,13920174 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08569986 0,13910351 ! methionine metabolic process GO:0006555 13 12 0,000 0,08569986 0,13900541 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08569986 0,13890745 ! Golgi organization GO:0007030 18 12 0,000 0,08569986 0,13880963 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08569986 0,13871194 ! monoamine transport GO:0015844 13 12 0,000 0,08569986 0,13861439 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08569986 0,13851698 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08569986 0,13841971 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08569986 0,13832257 ! L-amino acid transport GO:0015807 20 12 0,000 0,08569986 0,13822557 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08569986 0,13812871 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08569986 0,13803198 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08569986 0,13793539 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08569986 0,13783893 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08569986 0,13774261 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08569986 0,13764642 ! cerebellum development GO:0021549 13 12 0,000 0,08569986 0,13755036 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08569986 0,13745444 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08569986 0,13735865 ! histone acetylation GO:0016573 23 12 0,000 0,08569986 0,137263 ! histone methylation GO:0016571 15 12 0,000 0,08569986 0,13716748 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08569986 0,13707209 ! gland morphogenesis GO:0022612 23 12 0,000 0,08569986 0,13697684 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08569986 0,13688171 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08569986 0,13678672 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08569986 0,13669186 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08569986 0,13659714 ! intestinal absorption GO:0050892 19 12 0,000 0,08569986 0,13650254 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08569986 0,13640808 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08569986 0,13631374 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08569986 0,13621954 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08569986 0,13612546 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08569986 0,13603152 ! microspike assembly GO:0030035 23 12 0,000 0,08569986 0,1359377 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08569986 0,13584402 ! response to cold GO:0009409 14 12 0,000 0,08569986 0,13575046 ! axon guidance GO:0007411 99 66 1,000 0,08655557 0,13701157 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,08655557 0,13691734 ! regulation of immune effector process GO:0002697 101 66 1,000 0,08655557 0,13682324 ! learning or memory GO:0007611 123 68 1,000 0,09106126 0,14384678 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09250346 0,14602468 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09250346 0,14592453 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09250346 0,14582451 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09250346 0,14572463 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09250346 0,14562489 ! water transport GO:0006833 17 13 0,000 0,09250346 0,14552528 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09250346 0,14542581 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09250346 0,14532648 ! lipid localization GO:0010876 24 13 0,000 0,09250346 0,14522728 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09250346 0,14512822 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09250346 0,14502929 ! organelle fusion GO:0048284 28 13 0,000 0,09250346 0,14493049 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09250346 0,14483184 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09250346 0,14473331 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,09250346 0,14463492 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09250346 0,14453666 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09250346 0,14443854 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09250346 0,14434055 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,09250346 0,14424269 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09250346 0,14414496 ! cytokine metabolic process GO:0042107 17 13 0,000 0,09250346 0,14404737 ! NAD metabolic process GO:0019674 21 13 0,000 0,09250346 0,14394991 ! exocrine system development GO:0035272 27 13 0,000 0,09250346 0,14385258 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09250346 0,14375538 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09250346 0,14365832 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09250346 0,14356138 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09250346 0,14346458 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09250346 0,1433679 ! genitalia development GO:0048806 15 13 0,000 0,09250346 0,14327136 ! cellular pigmentation GO:0033059 24 13 0,000 0,09250346 0,14317494 ! tissue regeneration GO:0042246 21 13 0,000 0,09250346 0,14307866 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09250346 0,1429825 ! cofactor transport GO:0051181 19 13 0,000 0,09250346 0,14288648 ! NADP metabolic process GO:0006739 18 13 0,000 0,09250346 0,14279058 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09250346 0,14269481 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09250346 0,14259917 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09250346 0,14250366 ! gas transport GO:0015669 18 13 0,000 0,09250346 0,14240828 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09250346 0,14231302 ! regulation of axon extension GO:0030516 23 13 0,000 0,09250346 0,14221789 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09250346 0,14212289 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,09250346 0,14202801 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09250346 0,14193327 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09250346 0,14183864 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09250346 0,14174415 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09250346 0,14164978 ! response to metal ion GO:0010038 103 70 1,000 0,09563449 0,14634685 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,09563449 0,14624955 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,0979455 0,14968415 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09925683 0,15158746 ! superoxide anion generation GO:0042554 18 14 0,000 0,09925683 0,15148687 ! regulation of S phase GO:0033261 18 14 0,000 0,09925683 0,15138641 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09925683 0,15128609 ! myotube differentiation GO:0014902 21 14 0,000 0,09925683 0,1511859 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09925683 0,15108584 ! inositol metabolic process GO:0006020 20 14 0,000 0,09925683 0,15098592 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09925683 0,15088613 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09925683 0,15078646 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09925683 0,15068694 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09925683 0,15058754 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09925683 0,15048827 ! response to cAMP GO:0051591 19 14 0,000 0,09925683 0,15038914 ! startle response GO:0001964 21 14 0,000 0,09925683 0,15029013 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09925683 0,15019125 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09925683 0,15009251 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09925683 0,14999389 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09925683 0,14989541 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,09925683 0,14979705 ! glycine metabolic process GO:0006544 22 14 0,000 0,09925683 0,14969882 ! pituitary gland development GO:0021983 23 14 0,000 0,09925683 0,14960073 ! lysosomal transport GO:0007041 20 14 0,000 0,09925683 0,14950276 ! regulation of heart rate GO:0002027 23 14 0,000 0,09925683 0,14940491 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09925683 0,1493072 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09925683 0,14920961 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,09925683 0,14911215 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,09925683 0,14901482 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09925683 0,14891762 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09925683 0,14882054 ! axon cargo transport GO:0008088 27 14 0,000 0,09925683 0,14872359 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09925683 0,14862676 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09925683 0,14853006 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,09925683 0,14843349 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09925683 0,14833704 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09925683 0,14824072 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09925683 0,14814452 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09925683 0,14804845 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09925683 0,1479525 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09925683 0,14785668 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09925683 0,14776098 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09925683 0,1476654 ! muscle maintenance GO:0046716 19 14 0,000 0,09925683 0,14756995 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09925683 0,14747462 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09925683 0,14737941 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09925683 0,14728433 ! cell killing GO:0001906 20 14 0,000 0,09925683 0,14718937 ! cilium assembly GO:0042384 20 14 0,000 0,09925683 0,14709453 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09925683 0,14699981 ! response to hypoxia GO:0001666 132 72 1,000 0,10027229 0,14840816 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,10027229 0,14831272 ! tube morphogenesis GO:0035239 118 73 1,000 0,10261451 0,15167955 ! response to oxygen levels GO:0070482 137 74 1,000 0,1049718 0,15506432 ! protein import into nucleus GO:0006606 118 74 1,000 0,1049718 0,15496479 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10596032 0,15632376 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10596032 0,15622355 ! metencephalon development GO:0022037 19 15 0,000 0,10596032 0,15612347 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10596032 0,15602352 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10596032 0,1559237 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10596032 0,155824 ! skin development GO:0043588 25 15 0,000 0,10596032 0,15572444 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10596032 0,15562499 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10596032 0,15552568 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10596032 0,15542649 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10596032 0,15532743 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10596032 0,1552285 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10596032 0,15512969 ! adult walking behavior GO:0007628 25 15 0,000 0,10596032 0,15503101 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10596032 0,15493245 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10596032 0,15483402 ! centrosome cycle GO:0007098 16 15 0,000 0,10596032 0,15473571 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10596032 0,15463753 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,10596032 0,15453947 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10596032 0,15444153 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10596032 0,15434372 ! cerebral cortex development GO:0021987 29 15 0,000 0,10596032 0,15424604 ! response to osmotic stress GO:0006970 22 15 0,000 0,10596032 0,15414848 ! vesicle coating GO:0006901 25 15 0,000 0,10596032 0,15405104 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10596032 0,15395372 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,10596032 0,15385653 ! peptide secretion GO:0002790 27 15 0,000 0,10596032 0,15375946 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10596032 0,15366251 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10596032 0,15356568 ! neuron recognition GO:0008038 22 15 0,000 0,10596032 0,15346898 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10596032 0,1533724 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10596032 0,15327594 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10596032 0,1531796 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10596032 0,15308338 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10596032 0,15298728 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10596032 0,15289131 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10596032 0,15279545 ! organic cation transport GO:0015695 19 15 0,000 0,10596032 0,15269971 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10596032 0,1526041 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10596032 0,1525086 ! defense response to virus GO:0051607 27 15 0,000 0,10596032 0,15241322 ! peptide hormone processing GO:0016486 19 15 0,000 0,10596032 0,15231796 ! blood coagulation GO:0007596 116 75 1,000 0,10734381 0,15421035 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,10734381 0,15411409 ! regulation of ligase activity GO:0051340 114 75 1,000 0,10734381 0,15401795 ! nuclear import GO:0051170 121 75 1,000 0,10734381 0,15392192 ! tRNA metabolic process GO:0006399 95 76 1,000 0,1097302 0,15724577 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,11213062 0,16058557 ! gland development GO:0048732 148 77 1,000 0,11213062 0,16048564 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,11213062 0,16038584 ! protein secretion GO:0009306 27 16 0,000 0,11261431 0,16097757 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11261431 0,16087758 ! hormone secretion GO:0046879 25 16 0,000 0,11261431 0,16077772 ! bone remodeling GO:0046849 24 16 0,000 0,11261431 0,16067798 ! endothelial cell migration GO:0043542 22 16 0,000 0,11261431 0,16057837 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11261431 0,16047888 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11261431 0,16037951 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11261431 0,16028026 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11261431 0,16018114 ! glial cell development GO:0021782 24 16 0,000 0,11261431 0,16008214 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11261431 0,15998327 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11261431 0,15988451 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11261431 0,15978588 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11261431 0,15968737 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11261431 0,15958898 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11261431 0,15949071 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11261431 0,15939256 ! regulation of protein binding GO:0043393 27 16 0,000 0,11261431 0,15929453 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11261431 0,15919662 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11261431 0,15909884 ! protein export from nucleus GO:0006611 24 16 0,000 0,11261431 0,15900117 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11261431 0,15890362 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11261431 0,1588062 ! DNA replication initiation GO:0006270 25 16 0,000 0,11261431 0,15870889 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11261431 0,1586117 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11261431 0,15851463 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11261431 0,15841768 ! diencephalon development GO:0021536 25 16 0,000 0,11261431 0,15832085 ! oogenesis GO:0048477 23 16 0,000 0,11261431 0,15822413 ! neural crest cell migration GO:0001755 24 16 0,000 0,11261431 0,15812754 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11261431 0,15803106 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11261431 0,1579347 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11261431 0,15783846 ! steroid catabolic process GO:0006706 22 16 0,000 0,11261431 0,15774233 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11261431 0,15764632 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11261431 0,15755043 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11261431 0,15745465 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11261431 0,157359 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11261431 0,15726345 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11261431 0,15716803 ! nerve development GO:0021675 18 16 0,000 0,11261431 0,15707271 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11261431 0,15697752 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11261431 0,15688244 ! negative regulation of translation GO:0017148 22 16 0,000 0,11261431 0,15678747 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,11454474 0,15937865 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,11697223 0,16265787 ! T cell activation GO:0042110 134 79 1,000 0,11697223 0,16255959 ! regulation of lyase activity GO:0051339 133 79 1,000 0,11697223 0,16246143 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11921915 0,16548222 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11921915 0,16538241 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11921915 0,16528272 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11921915 0,16518316 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11921915 0,16508371 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11921915 0,16498438 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11921915 0,16488517 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11921915 0,16478608 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11921915 0,16468711 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11921915 0,16458826 ! memory GO:0007613 25 17 0,000 0,11921915 0,16448953 ! keratinization GO:0031424 17 17 0,000 0,11921915 0,16439091 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11921915 0,16429241 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11921915 0,16419404 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11921915 0,16409577 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,11921915 0,16399763 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11921915 0,16389961 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11921915 0,1638017 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11921915 0,1637039 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,11921915 0,16360623 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11921915 0,16350867 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11921915 0,16341123 ! membrane budding GO:0006900 29 17 0,000 0,11921915 0,1633139 ! heme metabolic process GO:0042168 27 17 0,000 0,11921915 0,16321669 ! actin filament bundle formation GO:0051017 26 17 0,000 0,11921915 0,1631196 ! body fluid secretion GO:0007589 27 17 0,000 0,11921915 0,16302262 ! stem cell differentiation GO:0048863 36 17 0,000 0,11921915 0,16292575 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11921915 0,162829 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11921915 0,16273237 ! sensory perception of pain GO:0019233 23 17 0,000 0,11921915 0,16263585 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11921915 0,16253944 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11921915 0,16244315 ! synaptogenesis GO:0007416 24 17 0,000 0,11921915 0,16234697 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,11921915 0,16225091 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11921915 0,16215496 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11921915 0,16205912 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11921915 0,1619634 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,11921915 0,16186779 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11921915 0,16177229 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11921915 0,16167691 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11921915 0,16158164 ! protein localization in nucleus GO:0034504 133 80 1,000 0,11941275 0,16174872 ! forebrain development GO:0030900 131 80 1,000 0,11941275 0,16165352 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,12186599 0,16487752 ! hemostasis GO:0007599 125 81 1,000 0,12186599 0,16478059 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,1257752 0,16996649 ! positive regulation of translation GO:0045727 28 18 0,000 0,1257752 0,16986669 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,1257752 0,169767 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,1257752 0,16966743 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,1257752 0,16956798 ! cAMP metabolic process GO:0046058 33 18 0,000 0,1257752 0,16946864 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,1257752 0,16936942 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,1257752 0,16927031 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,1257752 0,16917133 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,1257752 0,16907245 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,1257752 0,1689737 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,1257752 0,16887505 ! response to retinoic acid GO:0032526 25 18 0,000 0,1257752 0,16877653 ! pigmentation during development GO:0048066 31 18 0,000 0,1257752 0,16867811 ! central nervous system neuron development GO:0021954 30 18 0,000 0,1257752 0,16857982 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,1257752 0,16848163 ! fucose metabolic process GO:0006004 26 18 0,000 0,1257752 0,16838357 ! response to fungus GO:0009620 19 18 0,000 0,1257752 0,16828561 ! peptide cross-linking GO:0018149 31 18 0,000 0,1257752 0,16818777 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,1257752 0,16809004 ! heart process GO:0003015 27 18 0,000 0,1257752 0,16799243 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,1257752 0,16789493 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,1257752 0,16779754 ! visual learning GO:0008542 35 18 0,000 0,1257752 0,16770027 ! somitogenesis GO:0001756 24 18 0,000 0,1257752 0,16760311 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,1257752 0,16750606 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,1257752 0,16740912 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,1257752 0,1673123 ! vitamin transport GO:0051180 24 18 0,000 0,1257752 0,16721559 ! hormone transport GO:0009914 27 18 0,000 0,1257752 0,16711899 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,1257752 0,1670225 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,1257752 0,16692612 ! cell-cell recognition GO:0009988 20 18 0,000 0,1257752 0,16682985 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,1257752 0,1667337 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,1257752 0,16663765 ! regulation of glucose import GO:0046324 21 18 0,000 0,1257752 0,16654172 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,1257752 0,1664459 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,1257752 0,16635018 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,12680934 0,16762154 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,12929882 0,17081406 ! rRNA metabolic process GO:0016072 107 85 1,000 0,13179975 0,17401804 GO:0006364|rRNA processing, ! regulation of membrane potential GO:0042391 128 85 1,000 0,13179975 0,1739182 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,13179975 0,17381848 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13228283 0,17435559 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13228283 0,17425573 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13228283 0,17415599 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13228283 0,17405636 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,13228283 0,17395684 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,13228283 0,17385744 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,13228283 0,17375815 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13228283 0,17365897 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13228283 0,1735599 ! regeneration GO:0031099 32 19 0,000 0,13228283 0,17346095 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13228283 0,17336212 ! response to alkaloid GO:0043279 32 19 0,000 0,13228283 0,17326339 ! sensory perception of taste GO:0050909 23 19 0,000 0,13228283 0,17316478 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,13228283 0,17306628 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13228283 0,17296789 ! peroxisome organization GO:0007031 29 19 0,000 0,13228283 0,17286961 ! digestive system process GO:0022600 30 19 0,000 0,13228283 0,17277144 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13228283 0,17267339 ! response to vitamin A GO:0033189 26 19 0,000 0,13228283 0,17257545 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13228283 0,17247761 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13228283 0,17237989 ! sex determination GO:0007530 29 19 0,000 0,13228283 0,17228228 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13228283 0,17218478 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13228283 0,17208739 ! cytolysis GO:0019835 20 19 0,000 0,13228283 0,17199011 ! renal system process GO:0003014 35 19 0,000 0,13228283 0,17189294 ! vasodilation GO:0042311 33 19 0,000 0,13228283 0,17179589 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13228283 0,17169893 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13228283 0,17160209 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13228283 0,17150536 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13228283 0,17140874 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13228283 0,17131223 ! sarcomere organization GO:0045214 23 19 0,000 0,13228283 0,17121582 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13228283 0,17111952 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13228283 0,17102333 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13228283 0,17092725 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13228283 0,17083128 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13228283 0,17073542 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,13431184 0,173257 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13874239 0,17887191 ! iron ion transport GO:0006826 37 20 0,000 0,13874239 0,1787717 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13874239 0,17867161 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13874239 0,17857162 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13874239 0,17847175 ! response to vitamin GO:0033273 29 20 0,000 0,13874239 0,17837199 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13874239 0,17827234 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13874239 0,1781728 ! spinal cord development GO:0021510 31 20 0,000 0,13874239 0,17807338 ! response to ethanol GO:0045471 37 20 0,000 0,13874239 0,17797406 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13874239 0,17787486 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13874239 0,17777576 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13874239 0,17767678 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13874239 0,1775779 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13874239 0,17747914 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13874239 0,17738048 ! collagen fibril organization GO:0030199 45 20 0,000 0,13874239 0,17728194 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,13874239 0,1771835 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13874239 0,17708518 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13874239 0,17698696 ! collagen catabolic process GO:0030574 25 20 0,000 0,13874239 0,17688885 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13874239 0,17679085 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,13874239 0,17669296 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13874239 0,17659518 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,14191204 0,1805297 ! regulation of cell killing GO:0031341 34 21 0,000 0,14515422 0,18455208 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14515422 0,18445012 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14515422 0,18434827 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14515422 0,18424653 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14515422 0,18414491 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14515422 0,18404339 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14515422 0,18394199 ! protein amino acid acylation GO:0043543 37 21 0,000 0,14515422 0,1838407 ! vesicle docking GO:0048278 27 21 0,000 0,14515422 0,18373952 ! phototransduction GO:0007602 25 21 0,000 0,14515422 0,18363846 ! visual behavior GO:0007632 39 21 0,000 0,14515422 0,1835375 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14515422 0,18343666 ! ovarian follicle development GO:0001541 30 21 0,000 0,14515422 0,18333592 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14515422 0,1832353 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14515422 0,18313479 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14515422 0,18303438 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14515422 0,18293409 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14515422 0,18283391 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14515422 0,18273383 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14515422 0,18263387 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14515422 0,18253402 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14515422 0,18243427 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14515422 0,18233463 ! fatty acid transport GO:0015908 30 21 0,000 0,14515422 0,18223511 ! immunoglobulin production GO:0002377 33 21 0,000 0,14515422 0,18213569 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14515422 0,18203638 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,14515422 0,18193718 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14515422 0,18183808 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14515422 0,18173909 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,14515422 0,18164022 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14515422 0,18154144 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14515422 0,18144278 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14515422 0,18134422 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14515422 0,18124577 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14515422 0,18114743 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14515422 0,1810492 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,14960202 0,18649574 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,14960202 0,18639471 ! positive regulation of immune response GO:0050778 121 92 1,000 0,14960202 0,1862938 ! sulfur metabolic process GO:0006790 118 92 1,000 0,14960202 0,18619299 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15151869 0,18847647 ! viral genome replication GO:0019079 29 22 0,000 0,15151869 0,18837459 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15151869 0,18827282 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15151869 0,18817116 ! leukocyte adhesion GO:0007159 38 22 0,000 0,15151869 0,18806961 ! molting cycle process GO:0022404 40 22 0,000 0,15151869 0,18796817 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,15151869 0,18786684 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15151869 0,18776562 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,15151869 0,18766451 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,15151869 0,1875635 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15151869 0,18746261 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15151869 0,18736182 ! lysosome organization GO:0007040 37 22 0,000 0,15151869 0,18726114 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15151869 0,18716057 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,15151869 0,18706011 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15151869 0,18695976 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15151869 0,18685951 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15151869 0,18675937 ! membrane depolarization GO:0051899 35 22 0,000 0,15151869 0,18665934 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15151869 0,18655942 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,15151869 0,1864596 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15151869 0,18635989 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15151869 0,18626028 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15151869 0,18616078 ! blastocyst development GO:0001824 37 22 0,000 0,15151869 0,18606139 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,15218397 0,18677862 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,15218397 0,18667901 ! neuron fate commitment GO:0048663 32 23 0,000 0,15783613 0,19350912 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15783613 0,19340603 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15783613 0,19330304 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,15783613 0,19320017 ! vesicle targeting GO:0006903 32 23 0,000 0,15783613 0,1930974 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,15783613 0,19299474 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15783613 0,19289219 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15783613 0,19278976 ! interaction with host GO:0051701 37 23 0,000 0,15783613 0,19268743 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,15783613 0,1925852 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,15783613 0,19248309 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15783613 0,19238109 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15783613 0,19227919 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15783613 0,1921774 ! cell fate determination GO:0001709 45 23 0,000 0,15783613 0,19207572 ! pentose metabolic process GO:0019321 31 23 0,000 0,15783613 0,19197415 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15783613 0,19187268 ! spermatid development GO:0007286 33 23 0,000 0,15783613 0,19177132 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15783613 0,19167007 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15783613 0,19156892 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15783613 0,19146789 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,15783613 0,19136695 ! regulation of amine transport GO:0051952 38 23 0,000 0,15783613 0,19126613 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,15998187 0,19376424 ! in utero embryonic development GO:0001701 147 96 1,000 0,15998187 0,19366226 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,15998187 0,19356039 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,1641069 0,19844683 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,1641069 0,19834255 ! superoxide metabolic process GO:0006801 32 24 0,000 0,1641069 0,19823838 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,1641069 0,19813432 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,1641069 0,19803036 ! vacuole organization GO:0007033 39 24 0,000 0,1641069 0,19792652 ! neural crest cell development GO:0014032 39 24 0,000 0,1641069 0,19782278 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,1641069 0,19771916 ! glutathione metabolic process GO:0006749 29 24 0,000 0,1641069 0,19761564 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,1641069 0,19751223 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,1641069 0,19740893 ! extracellular structure organization GO:0043062 156 99 1,000 0,16785222 0,20180873 ! protein import GO:0017038 156 99 1,000 0,16785222 0,2017033 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17033133 0,20457549 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17033133 0,20446872 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17033133 0,20436206 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17033133 0,20425551 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,17033133 0,20414907 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17033133 0,20404274 ! peptide transport GO:0015833 43 25 0,000 0,17033133 0,20393652 ! male gonad development GO:0008584 33 25 0,000 0,17033133 0,20383042 ! iron ion homeostasis GO:0055072 39 25 0,000 0,17033133 0,20372442 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17033133 0,20361854 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,17033133 0,20351276 ! phospholipid transport GO:0015914 35 25 0,000 0,17033133 0,20340709 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17033133 0,20330154 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17033133 0,20319609 ! detection of light stimulus GO:0009583 30 25 0,000 0,17033133 0,20309075 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,17033133 0,20298552 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,17033133 0,2028804 GO:0032943|mononuclear cell proliferation, ! homophilic cell adhesion GO:0007156 149 100 1,000 0,17049056 0,20296496 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,17049056 0,20285996 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,17049056 0,20275507 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,17049056 0,20265028 ! protein localization in organelle GO:0033365 161 100 1,000 0,17049056 0,20254561 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17650977 0,20958826 ! translational initiation GO:0006413 43 26 0,000 0,17650977 0,20948011 ! circadian rhythm GO:0007623 42 26 0,000 0,17650977 0,20937208 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17650977 0,20926415 ! post-embryonic development GO:0009791 42 26 0,000 0,17650977 0,20915634 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,17650977 0,20904864 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17650977 0,20894105 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17650977 0,20883357 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17650977 0,2087262 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17650977 0,20861894 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17650977 0,20851179 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17650977 0,20840475 ! regulation of coagulation GO:0050818 39 26 0,000 0,17650977 0,20829782 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18264254 0,21542454 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,18264254 0,21531412 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18264254 0,21520381 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18264254 0,21509362 ! membrane docking GO:0022406 39 27 0,000 0,18264254 0,21498354 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18264254 0,21487358 ! catechol metabolic process GO:0009712 43 27 0,000 0,18264254 0,21476372 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18264254 0,21465398 ! acute-phase response GO:0006953 42 27 0,000 0,18264254 0,21454435 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18264254 0,21443484 ! myofibril assembly GO:0030239 36 27 0,000 0,18264254 0,21432543 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18264254 0,21421614 ! natural killer cell activation GO:0030101 35 27 0,000 0,18264254 0,21410695 ! lipid oxidation GO:0034440 38 27 0,000 0,18264254 0,21399788 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18264254 0,21388892 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18264254 0,21378007 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,18264254 0,21367133 ! gene silencing GO:0016458 41 27 0,000 0,18264254 0,21356271 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18872999 0,22056859 ! phenol metabolic process GO:0018958 44 28 0,000 0,18872999 0,22045657 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,18872999 0,22034466 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18872999 0,22023287 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18872999 0,22012119 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18872999 0,22000962 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18872999 0,21989817 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18872999 0,21978683 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,18872999 0,2196756 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,18872999 0,21956448 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18872999 0,21945348 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,18872999 0,21934259 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18872999 0,21923181 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18872999 0,21912114 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18872999 0,21901059 ! mesoderm formation GO:0001707 46 28 0,000 0,18872999 0,21890014 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,18872999 0,21878981 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18872999 0,21867959 ! BMP signaling pathway GO:0030509 40 28 0,000 0,18872999 0,21856948 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18872999 0,21845948 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,19477245 0,22534036 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19477245 0,22522707 ! ovulation cycle process GO:0022602 41 29 0,000 0,19477245 0,22511389 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,19477245 0,22500082 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19477245 0,22488787 ! mismatch repair GO:0006298 34 29 0,000 0,19477245 0,22477503 ! muscle cell development GO:0055001 38 29 0,000 0,19477245 0,22466231 ! formation of primary germ layer GO:0001704 48 29 0,000 0,19477245 0,22454969 ! eye morphogenesis GO:0048592 51 29 0,000 0,19477245 0,2244372 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19477245 0,22432481 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20077025 0,23111691 ! collagen metabolic process GO:0032963 40 30 0,000 0,20077025 0,23100129 ! organic anion transport GO:0015711 51 30 0,000 0,20077025 0,23088579 ! cholesterol transport GO:0030301 46 30 0,000 0,20077025 0,2307704 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,20077025 0,23065513 ! spliceosome assembly GO:0000245 49 30 0,000 0,20077025 0,23053998 ! spindle organization GO:0007051 37 30 0,000 0,20077025 0,23042494 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20077025 0,23031001 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20077025 0,2301952 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20077025 0,23008051 ! ovulation cycle GO:0042698 43 30 0,000 0,20077025 0,22996593 ! hindbrain development GO:0030902 45 30 0,000 0,20077025 0,22985146 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20077025 0,2297371 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20077025 0,22962286 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,20077025 0,22950874 ! negative regulation of secretion GO:0051048 49 31 0,000 0,20672372 0,23619699 ! glial cell differentiation GO:0010001 55 31 0,000 0,20672372 0,23607972 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,20672372 0,23596255 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20672372 0,23584551 ! odontogenesis GO:0042476 50 31 0,000 0,20672372 0,23572858 ! segmentation GO:0035282 41 31 0,000 0,20672372 0,23561177 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,20672372 0,23549507 ! metanephros development GO:0001656 58 31 0,000 0,20672372 0,23537849 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20672372 0,23526202 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,20672372 0,23514567 ! cell fate specification GO:0001708 37 31 0,000 0,20672372 0,23502944 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,20672372 0,23491331 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,20672372 0,23479731 ! RNA modification GO:0009451 40 31 0,000 0,20672372 0,23468142 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,21263317 0,24127099 ! meiosis I GO:0007127 52 32 0,000 0,21263317 0,24115202 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,21263317 0,24103317 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,21263317 0,24091443 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,21263317 0,24079581 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,21263317 0,24067731 ! cytokine production GO:0001816 44 32 0,000 0,21263317 0,24055893 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,21263317 0,24044066 ! vesicle localization GO:0051648 47 32 0,000 0,21263317 0,2403225 ! RNA export from nucleus GO:0006405 44 33 0,000 0,21849894 0,24683083 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,21849894 0,24670966 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,21849894 0,2465886 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,21849894 0,24646766 ! sister chromatid segregation GO:0000819 46 33 0,000 0,21849894 0,24634685 ! ear morphogenesis GO:0042471 42 33 0,000 0,21849894 0,24622615 ! actomyosin structure organization GO:0031032 43 33 0,000 0,21849894 0,24610557 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,21849894 0,2459851 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,21849894 0,24586476 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,21849894 0,24574453 ! female gonad development GO:0008585 49 33 0,000 0,21849894 0,24562442 ! lipid homeostasis GO:0055088 55 33 0,000 0,21849894 0,24550443 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,21849894 0,24538455 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,21849894 0,2452648 ! mRNA catabolic process GO:0006402 48 34 0,000 0,22432135 0,25167761 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,22432135 0,2515549 ! feeding behavior GO:0007631 45 34 0,000 0,22432135 0,25143231 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,22432135 0,25130984 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,22432135 0,25118749 ! female gamete generation GO:0007292 43 34 0,000 0,22432135 0,25106525 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,22432135 0,25094314 ! aerobic respiration GO:0009060 47 34 0,000 0,22432135 0,25082115 ! embryonic organ development GO:0048568 45 34 0,000 0,22432135 0,25069927 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,2301007 0,25703333 ! Notch signaling pathway GO:0007219 56 35 0,000 0,2301007 0,25690855 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,2301007 0,2567839 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,2301007 0,25665937 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,2301007 0,25653496 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,2301007 0,25641067 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,2301007 0,2562865 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,2301007 0,25616245 ! glycogen metabolic process GO:0005977 48 35 0,000 0,2301007 0,25603852 ! pigment metabolic process GO:0042440 61 35 0,000 0,2301007 0,25591471 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,23583733 0,26216813 GO:0090047|positive regulation of transcription regulator activity, ! organic ether metabolic process GO:0018904 46 36 0,000 0,23583733 0,26204148 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,23583733 0,26191495 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,23583733 0,26178854 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23583733 0,26166226 ! glucan metabolic process GO:0044042 49 36 0,000 0,23583733 0,26153609 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,24153154 0,2677217 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,24153154 0,26759274 ! ion transmembrane transport GO:0034220 56 37 0,000 0,24153154 0,26746391 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,24153154 0,2673352 ! regulation of protein secretion GO:0050708 51 37 0,000 0,24153154 0,26720661 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,24153154 0,26707814 ! gliogenesis GO:0042063 71 38 0,000 0,24718364 0,27319672 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,24718364 0,2730655 ! phagocytosis GO:0006909 60 38 0,000 0,24718364 0,27293441 ! pigmentation GO:0043473 74 38 0,000 0,24718364 0,27280344 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,25279394 0,27886142 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,25279394 0,27872774 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,25279394 0,27859419 ! male sex differentiation GO:0046661 53 39 0,000 0,25279394 0,27846076 ! chromatin remodeling GO:0006338 68 39 0,000 0,25279394 0,27832746 ! developmental growth GO:0048589 62 39 0,000 0,25279394 0,27819429 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,25836275 0,28418667 ! response to calcium ion GO:0051592 58 40 0,000 0,25836275 0,28405083 ! regulation of tube size GO:0035150 60 40 0,000 0,25836275 0,28391511 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,25836275 0,28377953 ! peptide metabolic process GO:0006518 56 40 0,000 0,25836275 0,28364407 ! inner ear development GO:0048839 57 40 0,000 0,25836275 0,28350875 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,25836275 0,28337355 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,25836275 0,28323848 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,26389038 0,28916049 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,26389038 0,2890228 ! glucose transport GO:0015758 52 41 0,000 0,26389038 0,28888523 ! striated muscle contraction GO:0006941 62 41 0,000 0,26389038 0,2887478 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,26389038 0,2886105 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,26937712 0,29447119 ! hexose transport GO:0008645 54 42 0,000 0,26937712 0,29433129 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,26937712 0,29419154 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,26937712 0,29405191 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,26937712 0,29391242 ! excretion GO:0007588 63 42 0,000 0,26937712 0,29377306 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,26937712 0,29363383 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,26937712 0,29349473 ! positive regulation of binding GO:0051099 59 43 0,000 0,27482328 0,29928671 ! leukocyte migration GO:0050900 60 43 0,000 0,27482328 0,29914507 ! neuromuscular process GO:0050905 79 43 0,000 0,27482328 0,29900357 ! tRNA processing GO:0008033 49 43 0,000 0,27482328 0,29886219 ! vesicle organization GO:0016050 79 43 0,000 0,27482328 0,29872095 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,28022915 0,30445302 ! glycolysis GO:0006096 53 44 0,000 0,28022915 0,30430927 ! regulation of ion transport GO:0043269 57 44 0,000 0,28022915 0,30416566 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,28022915 0,30402219 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,28022915 0,30387885 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,28022915 0,30373564 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,28022915 0,30359258 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,28022915 0,30344964 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,28022915 0,30330684 ! RNA catabolic process GO:0006401 64 45 0,000 0,28559503 0,30896922 ! positive regulation of defense response GO:0031349 59 45 0,000 0,28559503 0,30882396 ! regulation of translational initiation GO:0006446 64 45 0,000 0,28559503 0,30867884 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28559503 0,30853385 ! cell recognition GO:0008037 58 45 0,000 0,28559503 0,308389 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,29092121 0,31399286 ! cell redox homeostasis GO:0045454 63 46 0,000 0,29092121 0,31384558 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,29092121 0,31369844 ! regulation of ossification GO:0030278 71 46 0,000 0,29092121 0,31355144 ! histone modification GO:0016570 68 46 0,000 0,29092121 0,31340458 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,29620799 0,31895055 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,29620799 0,3188013 ! endocrine system development GO:0035270 83 47 0,000 0,29620799 0,31865218 ! covalent chromatin modification GO:0016569 75 47 0,000 0,29620799 0,31850321 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,29620799 0,31835438 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,29620799 0,31820568 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,29620799 0,31805713 ! chloride transport GO:0006821 67 48 0,000 0,30145565 0,32354083 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,30145565 0,32338992 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,30145565 0,32323916 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,30145565 0,32308853 ! gastrulation GO:0007369 73 48 0,000 0,30145565 0,32293805 ! heart morphogenesis GO:0003007 65 48 0,000 0,30145565 0,3227877 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,30145565 0,3226375 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,30145565 0,32248744 ! regulation of endocytosis GO:0030100 63 48 0,000 0,30145565 0,32233751 ! nuclear export GO:0051168 69 48 0,000 0,30145565 0,32218773 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,30666448 0,32760255 ! sensory perception of smell GO:0007608 61 49 0,000 0,30666448 0,32745046 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,30666448 0,32729852 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,30666448 0,32714671 ! RNA elongation GO:0006354 62 49 0,000 0,30666448 0,32699504 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,30666448 0,32684351 ! germ cell development GO:0007281 68 49 0,000 0,30666448 0,32669213 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,30666448 0,32654088 ! regulation of actin filament length GO:0030832 72 50 0,000 0,31183477 0,33189262 ! ear development GO:0043583 72 50 0,000 0,31183477 0,33173911 ! membrane fusion GO:0006944 80 50 0,000 0,31183477 0,33158574 ! proton transport GO:0015992 75 50 0,000 0,31183477 0,33143251 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,31183477 0,33127943 ! hydrogen transport GO:0006818 77 51 0,000 0,31696679 0,336576 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,31696679 0,33642068 ! adult behavior GO:0030534 80 51 0,000 0,31696679 0,33626551 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,31696679 0,33611048 ! transition metal ion transport GO:0000041 74 52 0,000 0,32206084 0,34135481 ! regulation of cellular component size GO:0032535 74 52 0,000 0,32206084 0,34119757 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,32206084 0,34104048 ! establishment of organelle localization GO:0051656 85 52 0,000 0,32206084 0,34088354 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,32711718 0,34607614 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,32711718 0,34591702 ! kidney development GO:0001822 90 53 0,000 0,32711718 0,34575805 ! single fertilization GO:0007338 59 53 0,000 0,32711718 0,34559923 ! cell projection assembly GO:0030031 76 53 0,000 0,32711718 0,34544055 ! amino acid transport GO:0006865 84 54 0,000 0,3321361 0,35057964 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,3321361 0,35041882 ! glucose catabolic process GO:0006007 66 54 0,000 0,3321361 0,35025816 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,3321361 0,35009763 ! detection of external stimulus GO:0009581 66 54 0,000 0,3321361 0,34993726 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,3321361 0,34977703 ! exocytosis GO:0006887 74 55 0,000 0,33711787 0,35486092 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,33711787 0,35469859 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,33711787 0,3545364 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,34206277 0,35957238 ! carbohydrate transport GO:0008643 74 57 0,000 0,34697106 0,3645653 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,34697106 0,36439883 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,34697106 0,36423251 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,34697106 0,36406635 ! camera-type eye development GO:0043010 88 57 0,000 0,34697106 0,36390033 ! secondary metabolic process GO:0019748 84 57 0,000 0,34697106 0,36373447 ! gonad development GO:0008406 79 57 0,000 0,34697106 0,36356876 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,35184301 0,36850588 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,35184301 0,36833815 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,35667889 0,37323087 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,35667889 0,37306114 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,36147897 0,37790983 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,36147897 0,37773813 ! regulation of heart contraction GO:0008016 91 60 0,000 0,36147897 0,37756659 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,36147897 0,3773952 ! fertilization GO:0009566 68 60 0,000 0,36147897 0,37722397 ! meiosis GO:0007126 96 61 0,000 0,3662435 0,3820227 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,3662435 0,38184953 ! urogenital system development GO:0001655 101 61 0,000 0,3662435 0,38167651 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,3662435 0,38150365 ! extracellular matrix organization GO:0030198 103 61 0,000 0,3662435 0,38133095 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,3662435 0,3811584 ! amine catabolic process GO:0009310 90 62 0,000 0,37097276 0,38590563 ! neurotransmitter transport GO:0006836 81 62 0,000 0,37097276 0,38573117 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,37097276 0,38555687 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,37097276 0,38538272 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,37097276 0,38520873 ! meiotic cell cycle GO:0051321 97 62 0,000 0,37097276 0,3850349 ! organelle localization GO:0051640 96 62 0,000 0,37097276 0,38486123 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,38032646 0,39438722 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,38032646 0,39420949 ! hexose catabolic process GO:0019320 82 64 0,000 0,38032646 0,39403192 ! reproductive structure development GO:0048608 90 65 0,000 0,38495142 0,39864398 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,38495142 0,39846457 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,38495142 0,39828532 ! defense response to bacterium GO:0042742 73 65 0,000 0,38495142 0,39810624 ! activation of immune response GO:0002253 83 65 0,000 0,38495142 0,39792731 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,38954213 0,40249186 ! antigen processing and presentation GO:0019882 96 66 0,000 0,38954213 0,40231113 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,39409883 0,40683452 ! acute inflammatory response GO:0002526 92 68 0,000 0,39862178 0,41131902 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,39862178 0,41113457 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,39862178 0,41095029 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,39862178 0,41076617 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,39862178 0,41058222 ! rhythmic process GO:0048511 105 68 0,000 0,39862178 0,41039843 ! inorganic anion transport GO:0015698 93 68 0,000 0,39862178 0,4102148 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,40311122 0,41464929 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,40311122 0,41446393 ! humoral immune response GO:0006959 86 70 0,000 0,40756741 0,41885837 ! eye development GO:0001654 111 70 0,000 0,40756741 0,4186713 ! amine transport GO:0015837 101 70 0,000 0,40756741 0,41848439 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,40756741 0,41829765 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,41199058 0,42264867 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,41199058 0,42246024 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,41199058 0,42227198 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,41638097 0,42658184 ! regulation of blood pressure GO:0008217 107 73 0,000 0,42073884 0,43085456 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,42073884 0,43066281 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,42073884 0,43047123 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,42506442 0,43470349 ! digestion GO:0007586 97 74 0,000 0,42506442 0,43451029 ! response to nutrient GO:0007584 104 75 0,000 0,42935794 0,43870425 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,42935794 0,43850944 ! amine biosynthetic process GO:0009309 97 76 0,000 0,43361964 0,44266541 ! response to unfolded protein GO:0006986 99 76 0,000 0,43361964 0,44246902 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,43784976 0,44658734 ! sex differentiation GO:0007548 105 77 0,000 0,43784976 0,44638938 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,43784976 0,4461916 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,44204853 0,45027086 ! cellular respiration GO:0045333 107 79 0,000 0,44621617 0,45431483 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,44621617 0,4541138 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,44621617 0,45391296 ! chromatin assembly GO:0031497 102 80 0,000 0,45035292 0,45791854 GO:0006334|nucleosome assembly, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,45035292 0,45771618 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,45035292 0,45751401 ! mRNA transport GO:0051028 121 81 0,000 0,45445901 0,46148156 ! response to protein stimulus GO:0051789 111 81 0,000 0,45445901 0,4612779 ! regulation of neurological system process GO:0031644 122 81 0,000 0,45445901 0,46107443 ! vitamin metabolic process GO:0006766 103 81 0,000 0,45445901 0,46087113 ! detection of stimulus GO:0051606 108 82 0,000 0,45853466 0,46479934 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,46258009 0,46869348 ! regulation of defense response GO:0031347 117 84 0,000 0,46659553 0,47255381 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,46659553 0,47234582 ! sterol metabolic process GO:0016125 120 84 0,000 0,46659553 0,47213802 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,47058119 0,47596163 ! transcription initiation GO:0006352 118 85 0,000 0,47058119 0,47575241 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,47058119 0,47554338 ! nucleosome organization GO:0034728 114 87 0,000 0,47846407 0,48329704 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,47846407 0,48308488 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,47846407 0,48287291 ! female pregnancy GO:0007565 130 87 0,000 0,47846407 0,48266113 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,48236173 0,48637964 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,48236173 0,48616651 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,48236173 0,48595356 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,48236173 0,48574079 ! reproductive developmental process GO:0003006 127 89 0,000 0,48623047 0,48942236 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,48623047 0,48920826 ! hormone metabolic process GO:0042445 121 90 0,000 0,49007053 0,49285623 ! RNA localization GO:0006403 135 91 0,000 0,4938821 0,49647239 ! ATP metabolic process GO:0046034 137 91 0,000 0,4938821 0,49625549 ! response to virus GO:0009615 122 91 0,000 0,4938821 0,49603879 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,50142063 0,50339041 ! electron transport chain GO:0022900 123 94 0,000 0,505148 0,50691117 ! carboxylic acid transport GO:0046942 147 95 0,000 0,50884772 0,51040112 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,51251999 0,5138605 ! protein maturation GO:0051604 129 96 0,000 0,51251999 0,5136366 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,51616502 0,51706426 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,52337413 0,52405768 ! regulation of translation GO:0006417 151 100 0,000 0,52693861 0,52739721 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,52693861 0,52716781 ! divalent metal ion transport GO:0070838 171 100 0,000 0,52693861 0,52693861