pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6693-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 4,000 1,453E-09 3,496E-06 ! polyol catabolic process GO:0046174 7 5 3,000 5,234E-09 6,297E-06 GO:0019405|alditol catabolic process, ! B cell lineage commitment GO:0002326 21 7 3,000 3,631E-08 2,912E-05 ! androgen receptor signaling pathway GO:0030521 74 36 5,000 5,56E-08 3,344E-05 ! interphase of mitotic cell cycle GO:0051329 209 95 7,000 8,007E-08 3,853E-05 ! interphase GO:0051325 213 98 7,000 1,022E-07 4,097E-05 ! cell cycle arrest GO:0007050 213 100 7,000 1,196E-07 4,112E-05 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 5,000 2,55E-07 7,668E-05 ! cellular carbohydrate catabolic process GO:0044275 15 13 3,000 7,221E-07 1,93E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 5,000 9,375E-07 2,256E-04 ! hexose biosynthetic process GO:0019319 48 32 4,000 1,048E-06 2,293E-04 ! positive regulation of MAP kinase activity GO:0043406 160 93 6,000 1,142E-06 2,291E-04 ! steroid hormone receptor signaling pathway GO:0030518 129 63 5,000 1,706E-06 3,158E-04 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 2,000 1,847E-06 3,174E-04 ! monosaccharide biosynthetic process GO:0046364 52 36 4,000 1,926E-06 3,09E-04 ! negative regulation of DNA binding GO:0043392 68 37 4,000 2,217E-06 3,333E-04 ! negative regulation of protein kinase activity GO:0006469 130 67 5,000 2,459E-06 3,48E-04 ! negative regulation of kinase activity GO:0033673 131 68 5,000 2,684E-06 3,587E-04 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 5,000 2,684E-06 3,399E-04 ! negative regulation of binding GO:0051100 72 40 4,000 3,3E-06 3,97E-04 ! myoblast cell fate commitment GO:0048625 16 6 2,000 3,679E-06 4,215E-04 ! negative regulation of transferase activity GO:0051348 140 72 5,000 3,759E-06 4,111E-04 ! G1 phase GO:0051318 40 19 3,000 3,81E-06 3,986E-04 ! alcohol biosynthetic process GO:0046165 59 42 4,000 4,227E-06 4,237E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 4,742E-06 4,563E-04 ! cytokinesis during cell cycle GO:0033205 11 7 2,000 6,41E-06 5,932E-04 ! activation of JUN kinase activity GO:0007257 42 22 3,000 7,095E-06 6,322E-04 ! JNK cascade GO:0007254 91 47 4,000 7,447E-06 6,399E-04 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 4,000 9,172E-06 7,61E-04 ! positive regulation of insulin secretion GO:0032024 15 8 2,000 1,021E-05 8,191E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 1,021E-05 7,927E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 1,021E-05 7,679E-04 ! alditol metabolic process GO:0019400 38 24 3,000 1,021E-05 7,447E-04 ! response to UV GO:0009411 104 53 4,000 1,355E-05 9,588E-04 ! positive regulation of JUN kinase activity GO:0043507 51 26 3,000 1,424E-05 9,791E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 2,000 1,525E-05 1,02E-03 ! regulation of JUN kinase activity GO:0043506 58 28 3,000 1,933E-05 1,257E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 2,17E-05 1,374E-03 ! DNA ligation GO:0006266 19 10 2,000 2,17E-05 1,339E-03 ! negative regulation of transcription regulator activity GO:0090048 58 31 3,000 2,931E-05 1,763E-03 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of peptide secretion GO:0002793 22 11 2,000 2,971E-05 1,744E-03 ! negative regulation of protein transport GO:0051224 69 33 3,000 3,778E-05 2,164E-03 ! regulation of B cell proliferation GO:0030888 20 12 2,000 3,945E-05 2,207E-03 ! regulation of hormone metabolic process GO:0032350 26 12 2,000 3,945E-05 2,157E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 3,945E-05 2,109E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of cell growth GO:0030308 132 67 4,000 4,274E-05 2,235E-03 ! activation of MAPK activity GO:0000187 115 67 4,000 4,274E-05 2,188E-03 ! negative regulation of cell size GO:0045792 134 69 4,000 4,927E-05 2,47E-03 ! cytoplasmic sequestering of protein GO:0051220 24 13 2,000 5,107E-05 2,507E-03 ! actin cytoskeleton reorganization GO:0031532 33 14 2,000 6,472E-05 3,114E-03 ! epithelial to mesenchymal transition GO:0001837 28 15 2,000 8,056E-05 3,8E-03 ! polyol metabolic process GO:0019751 66 41 3,000 9,021E-05 4,174E-03 ! G1 phase of mitotic cell cycle GO:0000080 35 16 2,000 9,873E-05 4,482E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 2,000 9,873E-05 4,399E-03 ! fructose metabolic process GO:0006000 25 16 2,000 9,873E-05 4,319E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 9,873E-05 4,242E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of intracellular protein transport GO:0033157 80 42 3,000 9,926E-05 4,19E-03 ! B cell differentiation GO:0030183 107 44 3,000 1,193E-04 4,949E-03 ! myoblast differentiation GO:0045445 45 17 2,000 1,194E-04 4,868E-03 ! negative regulation of protein catabolic process GO:0042177 40 17 2,000 1,194E-04 4,787E-03 ! negative regulation of growth GO:0045926 155 84 4,000 1,263E-04 4,981E-03 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 3,000 1,421E-04 5,516E-03 ! regulation of JNK cascade GO:0046328 94 47 3,000 1,547E-04 5,907E-03 ! regulation of DNA binding GO:0051101 155 88 4,000 1,573E-04 5,914E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 3,000 1,68E-04 6,218E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 1,68E-04 6,124E-03 ! positive regulation of hormone secretion GO:0046887 32 19 2,000 1,687E-04 6,058E-03 ! pancreas development GO:0031016 35 20 2,000 1,976E-04 6,992E-03 ! negative regulation of T cell activation GO:0050868 40 20 2,000 1,976E-04 6,891E-03 ! carbohydrate biosynthetic process GO:0016051 141 93 4,000 2,039E-04 7,01E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 2,129E-04 7,214E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cell aging GO:0007569 44 21 2,000 2,296E-04 7,672E-03 ! negative regulation of intracellular transport GO:0032387 41 21 2,000 2,296E-04 7,567E-03 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 2,000 2,647E-04 8,607E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 2,647E-04 8,492E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 2,647E-04 8,38E-03 ! regulation of protein catabolic process GO:0042176 116 55 3,000 2,854E-04 8,917E-03 ! aging GO:0007568 103 55 3,000 2,854E-04 8,803E-03 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 2,000 3,031E-04 9,232E-03 ! gluconeogenesis GO:0006094 33 23 2,000 3,031E-04 9,117E-03 ! negative regulation of catabolic process GO:0009895 50 23 2,000 3,031E-04 9,004E-03 ! skeletal muscle fiber development GO:0048741 111 56 3,000 3,06E-04 8,977E-03 ! regulation of DNA replication GO:0006275 101 56 3,000 3,06E-04 8,869E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,244E-04 9,291E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 3,244E-04 9,181E-03 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 1,000 3,244E-04 9,075E-03 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 3,244E-04 8,97E-03 ! regulation of retroviral genome replication GO:0045091 7 5 1,000 3,244E-04 8,868E-03 ! valine metabolic process GO:0006573 10 5 1,000 3,244E-04 8,769E-03 ! positive regulation of filopodium assembly GO:0051491 14 5 1,000 3,244E-04 8,671E-03 GO:0051489|regulation of filopodium assembly, ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 3,244E-04 8,576E-03 ! early endosome to late endosome transport GO:0045022 12 5 1,000 3,244E-04 8,483E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 3,244E-04 8,391E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 3,244E-04 8,302E-03 ! stem cell division GO:0017145 11 5 1,000 3,244E-04 8,215E-03 GO:0048103|somatic stem cell division, ! muscle fiber development GO:0048747 112 57 3,000 3,276E-04 8,21E-03 ! regulation of intracellular transport GO:0032386 101 57 3,000 3,276E-04 8,126E-03 ! negative regulation of phosphorylation GO:0042326 47 24 2,000 3,45E-04 8,47E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 2,000 3,904E-04 9,487E-03 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 2,000 3,904E-04 9,392E-03 ! sperm motility GO:0030317 31 25 2,000 3,904E-04 9,299E-03 ! negative regulation of cell development GO:0010721 73 25 2,000 3,904E-04 9,208E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of insulin secretion GO:0050796 37 25 2,000 3,904E-04 9,119E-03 ! pyruvate metabolic process GO:0006090 38 26 2,000 4,394E-04 0,01016609 ! regulation of transcription factor import into nucleus GO:0042990 54 26 2,000 4,394E-04 0,01006927 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 2,000 4,394E-04 9,974E-03 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of actin filament polymerization GO:0030838 11 6 1,000 4,847E-04 0,01089895 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 1,000 4,847E-04 0,01079803 ! neuron remodeling GO:0016322 15 6 1,000 4,847E-04 0,01069897 ! activation of MAPKKK activity GO:0000185 12 6 1,000 4,847E-04 0,0106017 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,847E-04 0,01050619 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 11 6 1,000 4,847E-04 0,01041239 ! positive regulation of cytokine production during immune response GO:0002720 9 6 1,000 4,847E-04 0,01032024 ! enucleate erythrocyte differentiation GO:0043353 12 6 1,000 4,847E-04 0,01022971 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 4,847E-04 0,01014076 ! negative regulation of B cell activation GO:0050869 13 6 1,000 4,847E-04 0,01005334 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 4,923E-04 0,01012331 ! positive regulation of cell projection organization GO:0031346 58 27 2,000 4,923E-04 0,01003752 ! fat cell differentiation GO:0045444 50 27 2,000 4,923E-04 9,953E-03 ! base-excision repair GO:0006284 41 27 2,000 4,923E-04 9,87E-03 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 4,923E-04 9,789E-03 ! regulation of cellular response to stress GO:0080135 128 67 3,000 6,08E-04 0,01198965 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 3,000 6,08E-04 0,01189217 ! regulation of peptide secretion GO:0002791 47 29 2,000 6,098E-04 0,01183226 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 6,098E-04 0,0117376 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 6,747E-04 0,01288386 ! regulation of B cell activation GO:0050864 50 30 2,000 6,747E-04 0,01278241 ! regulation of helicase activity GO:0051095 15 7 1,000 6,76E-04 0,01270698 ! regulation of lipid kinase activity GO:0043550 13 7 1,000 6,76E-04 0,01260847 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 6,76E-04 0,01251149 ! mRNA stabilization GO:0048255 18 7 1,000 6,76E-04 0,01241598 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 10 7 1,000 6,76E-04 0,01232192 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 6,76E-04 0,01222927 ! T cell lineage commitment GO:0002360 16 7 1,000 6,76E-04 0,01213801 ! response to tumor cell GO:0002347 13 7 1,000 6,76E-04 0,0120481 ! cell cycle checkpoint GO:0000075 137 69 3,000 6,796E-04 0,01202334 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 2,000 7,439E-04 0,01306382 ! B cell activation GO:0042113 160 71 3,000 7,571E-04 0,01319948 ! regulation of MAPKKK cascade GO:0043408 142 71 3,000 7,571E-04 0,01310452 ! response to ionizing radiation GO:0010212 65 32 2,000 8,174E-04 0,01404706 ! regulation of protein import into nucleus GO:0042306 63 32 2,000 8,174E-04 0,01394743 ! regulation of transcription factor activity GO:0051090 126 74 3,000 8,847E-04 0,01498934 GO:0090046|regulation of transcription regulator activity, ! positive regulation of neurogenesis GO:0050769 67 33 2,000 8,953E-04 0,01506404 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 8,979E-04 0,01500324 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 8,979E-04 0,01489977 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 8,979E-04 0,01479772 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 8,979E-04 0,01469705 ! mast cell activation GO:0045576 14 8 1,000 8,979E-04 0,01459775 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 1,000 8,979E-04 0,01449978 ! succinate metabolic process GO:0006105 14 8 1,000 8,979E-04 0,01440311 ! T-helper 1 type immune response GO:0042088 12 8 1,000 8,979E-04 0,01430773 ! ER overload response GO:0006983 12 8 1,000 8,979E-04 0,0142136 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 8,979E-04 0,0141207 ! regulation of vascular permeability GO:0043114 12 8 1,000 8,979E-04 0,014029 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 1,000 8,979E-04 0,01393849 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 1,000 8,979E-04 0,01384914 ! DNA topological change GO:0006265 12 8 1,000 8,979E-04 0,01376093 ! multicellular organismal aging GO:0010259 18 8 1,000 8,979E-04 0,01367384 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 8,979E-04 0,01358784 ! lymphocyte differentiation GO:0030098 167 75 3,000 9,304E-04 0,01399016 ! regulation of catabolic process GO:0009894 161 76 3,000 9,777E-04 0,01461056 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 2,000 9,778E-04 0,01452284 ! negative regulation of cell adhesion GO:0007162 81 35 2,000 1,065E-03 0,0157206 ! activation of protein kinase activity GO:0032147 147 79 3,000 1,13E-03 0,01657504 ! positive regulation of phosphorylation GO:0042327 129 79 3,000 1,13E-03 0,01647459 ! DNA synthesis during DNA repair GO:0000731 14 9 1,000 1,15E-03 0,01667022 ! induction of positive chemotaxis GO:0050930 15 9 1,000 1,15E-03 0,0165704 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 1,000 1,15E-03 0,01647176 ! microtubule bundle formation GO:0001578 21 9 1,000 1,15E-03 0,0163743 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,15E-03 0,01627798 GO:0006600|creatine metabolic process, ! receptor clustering GO:0043113 18 9 1,000 1,15E-03 0,01618278 ! motor axon guidance GO:0008045 16 9 1,000 1,15E-03 0,0160887 ! regulation of macrophage differentiation GO:0045649 15 9 1,000 1,15E-03 0,0159957 ! pyrimidine base metabolic process GO:0006206 17 9 1,000 1,15E-03 0,01590377 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 2,000 1,157E-03 0,0159067 ! maintenance of protein location in cell GO:0032507 86 36 2,000 1,157E-03 0,01581632 ! positive regulation of cell development GO:0010720 80 36 2,000 1,157E-03 0,01572696 ! negative regulation of cell activation GO:0050866 65 36 2,000 1,157E-03 0,01563861 ! muscle cell differentiation GO:0042692 159 80 3,000 1,184E-03 0,01591447 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 3,000 1,24E-03 0,0165744 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of neuron differentiation GO:0045664 167 81 3,000 1,24E-03 0,01648283 ! regulation of protein stability GO:0031647 73 37 2,000 1,254E-03 0,01657459 ! carbohydrate homeostasis GO:0033500 53 38 2,000 1,356E-03 0,01782184 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 67 38 2,000 1,356E-03 0,01772498 ! negative regulation of transport GO:0051051 153 84 3,000 1,419E-03 0,01845494 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 1,432E-03 0,01852697 ! lung alveolus development GO:0048286 26 10 1,000 1,432E-03 0,0184279 ! negative regulation of striated muscle development GO:0045843 19 10 1,000 1,432E-03 0,01832988 ! V(D)J recombination GO:0033151 28 10 1,000 1,432E-03 0,01823289 ! nucleobase biosynthetic process GO:0046112 24 10 1,000 1,432E-03 0,01813693 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 1,432E-03 0,01804197 ! regulation of bone resorption GO:0045124 25 10 1,000 1,432E-03 0,01794801 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,432E-03 0,01785501 GO:0045685|regulation of glial cell differentiation, ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 1,432E-03 0,01776297 ! positive regulation of viral reproduction GO:0048524 18 10 1,000 1,432E-03 0,01767188 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 1,432E-03 0,01758172 ! localization within membrane GO:0051668 20 10 1,000 1,432E-03 0,01749247 ! mitochondrion organization GO:0007005 148 86 3,000 1,548E-03 0,01880972 ! alcohol catabolic process GO:0046164 130 86 3,000 1,548E-03 0,01871519 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 2,000 1,574E-03 0,01893839 ! regulation of hormone secretion GO:0046883 62 40 2,000 1,574E-03 0,01884417 ! mesenchymal cell development GO:0014031 87 40 2,000 1,574E-03 0,01875088 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 91 40 2,000 1,574E-03 0,01865851 ! cytokinesis GO:0000910 72 40 2,000 1,574E-03 0,01856705 ! regulation of protein transport GO:0051223 154 87 3,000 1,615E-03 0,01895866 GO:0070201|regulation of establishment of protein localization, ! regulation of T cell proliferation GO:0042129 71 41 2,000 1,691E-03 0,01975519 ! regulation of T cell differentiation GO:0045580 70 41 2,000 1,691E-03 0,01965976 ! negative regulation of muscle development GO:0048635 20 11 1,000 1,744E-03 0,02017266 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 1,744E-03 0,02007614 ! blood vessel remodeling GO:0001974 29 11 1,000 1,744E-03 0,01998054 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 1,744E-03 0,01988584 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 22 11 1,000 1,744E-03 0,01979204 ! negative regulation of proteolysis GO:0045861 25 11 1,000 1,744E-03 0,01969912 ! regulation of intracellular pH GO:0051453 19 11 1,000 1,744E-03 0,01960707 ! positive regulation of T cell mediated immunity GO:0002711 24 11 1,000 1,744E-03 0,01951587 ! nitric oxide metabolic process GO:0046209 15 11 1,000 1,744E-03 0,01942552 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 1,000 1,744E-03 0,019336 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 24 11 1,000 1,744E-03 0,01924731 ! regulation of leukocyte migration GO:0002685 26 11 1,000 1,744E-03 0,01915942 ! lysogeny GO:0030069 21 11 1,000 1,744E-03 0,01907233 GO:0019047|provirus integration, ! regulation of cell morphogenesis GO:0022604 215 89 3,000 1,756E-03 0,01912011 ! regulation of cell adhesion GO:0030155 212 89 3,000 1,756E-03 0,01903398 ! ossification GO:0001503 188 90 3,000 1,83E-03 0,01974221 ! regulation of cell cycle process GO:0010564 149 90 3,000 1,83E-03 0,01965407 ! bone development GO:0060348 189 91 3,000 1,905E-03 0,02037579 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 2,000 1,942E-03 0,02067213 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 1,942E-03 0,02058106 ! double-strand break repair GO:0006302 81 44 2,000 2,075E-03 0,021898 ! JAK-STAT cascade GO:0007259 71 44 2,000 2,075E-03 0,02180237 ! maintenance of location in cell GO:0051651 97 44 2,000 2,075E-03 0,02170758 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 1,000 2,085E-03 0,02171477 ! cartilage condensation GO:0001502 20 12 1,000 2,085E-03 0,02162117 ! regulation of positive chemotaxis GO:0050926 19 12 1,000 2,085E-03 0,02152838 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 2,085E-03 0,02143638 ! regulation of cell projection assembly GO:0060491 30 12 1,000 2,085E-03 0,02134516 ! hippocampus development GO:0021766 26 12 1,000 2,085E-03 0,02125471 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 1,000 2,085E-03 0,02116503 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 2,085E-03 0,0210761 ! regulation of T cell activation GO:0050863 158 94 3,000 2,145E-03 0,02159769 ! regulation of JAK-STAT cascade GO:0046425 70 45 2,000 2,214E-03 0,02219568 ! induction of apoptosis by intracellular signals GO:0008629 93 45 2,000 2,214E-03 0,02210358 ! leukocyte differentiation GO:0002521 202 96 3,000 2,316E-03 0,0230307 ! regulation of DNA metabolic process GO:0051052 178 97 3,000 2,405E-03 0,02381669 ! regulation of protein localization GO:0032880 176 97 3,000 2,405E-03 0,02371908 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 2,455E-03 0,02410528 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 1,000 2,455E-03 0,02400729 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-cell junction assembly GO:0007043 27 13 1,000 2,455E-03 0,02391009 ! response to X-ray GO:0010165 25 13 1,000 2,455E-03 0,02381368 ! regulation of cytokine production during immune response GO:0002718 23 13 1,000 2,455E-03 0,02371805 ! regulation of cellular pH GO:0030641 22 13 1,000 2,455E-03 0,02362317 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 2,455E-03 0,02352906 ! regulation of mRNA stability GO:0043488 31 13 1,000 2,455E-03 0,02343569 ! positive regulation of protein polymerization GO:0032273 25 13 1,000 2,455E-03 0,02334306 ! skeletal muscle tissue development GO:0007519 186 99 3,000 2,59E-03 0,02453677 GO:0060538|skeletal muscle organ development, ! activation of caspase activity GO:0006919 84 48 2,000 2,665E-03 0,02514418 ! regulation of lymphocyte differentiation GO:0045619 81 48 2,000 2,665E-03 0,02504596 ! regulation of mRNA processing GO:0050684 24 14 1,000 2,853E-03 0,02670871 ! bone mineralization GO:0030282 17 14 1,000 2,853E-03 0,02660519 ! non-recombinational repair GO:0000726 25 14 1,000 2,853E-03 0,02650247 GO:0006303|double-strand break repair via nonhomologous end joining, ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 2,853E-03 0,02640054 ! response to gamma radiation GO:0010332 28 14 1,000 2,853E-03 0,02629939 ! regulation of RNA stability GO:0043487 32 14 1,000 2,853E-03 0,02619901 ! release of cytochrome c from mitochondria GO:0001836 30 14 1,000 2,853E-03 0,02609939 ! regulation of cell projection organization GO:0031344 121 50 2,000 2,995E-03 0,02729249 ! negative regulation of immune system process GO:0002683 95 50 2,000 2,995E-03 0,0271895 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 2,000 3,169E-03 0,0286599 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 2,000 3,169E-03 0,02855256 ! regulation of cell shape GO:0008360 125 51 2,000 3,169E-03 0,02844602 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 3,279E-03 0,02933213 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 3,279E-03 0,02922349 ! G1/S transition checkpoint GO:0031575 40 15 1,000 3,279E-03 0,02911565 ! positive regulation of axonogenesis GO:0050772 28 15 1,000 3,279E-03 0,02900861 ! regulation of T cell mediated immunity GO:0002709 33 15 1,000 3,279E-03 0,02890235 ! synaptic transmission, cholinergic GO:0007271 24 15 1,000 3,279E-03 0,02879687 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 3,734E-03 0,03266763 ! activation of MAPKK activity GO:0000186 35 16 1,000 3,734E-03 0,03254927 ! induction of apoptosis via death domain receptors GO:0008625 20 16 1,000 3,734E-03 0,03243177 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 3,734E-03 0,0323151 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of protein import into nucleus GO:0042307 30 16 1,000 3,734E-03 0,03219928 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 3,734E-03 0,03208428 ! biomineral formation GO:0031214 20 16 1,000 3,734E-03 0,0319701 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,734E-03 0,03185673 ! positive regulation of caspase activity GO:0043280 95 55 2,000 3,925E-03 0,03337274 GO:0010952|positive regulation of peptidase activity, ! positive regulation of protein complex assembly GO:0031334 32 17 1,000 4,216E-03 0,03571519 ! signal complex assembly GO:0007172 41 17 1,000 4,216E-03 0,03558988 ! limbic system development GO:0021761 36 17 1,000 4,216E-03 0,03546544 ! regulation of viral genome replication GO:0045069 28 17 1,000 4,216E-03 0,03534186 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 1,000 4,216E-03 0,03521915 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 4,216E-03 0,03509728 ! DNA integration GO:0015074 29 17 1,000 4,216E-03 0,03497626 ! nucleobase metabolic process GO:0009112 37 17 1,000 4,216E-03 0,03485606 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 1,000 4,216E-03 0,03473669 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 1,000 4,216E-03 0,03461814 ! branched chain family amino acid metabolic process GO:0009081 33 17 1,000 4,216E-03 0,03450039 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 4,216E-03 0,03438344 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 4,216E-03 0,03426728 ! positive regulation of cell migration GO:0030335 126 57 2,000 4,342E-03 0,03517071 ! maintenance of location GO:0051235 118 57 2,000 4,342E-03 0,03505268 ! neuron maturation GO:0042551 42 18 1,000 4,725E-03 0,03802041 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 4,725E-03 0,03789367 ! protein amino acid ADP-ribosylation GO:0006471 33 18 1,000 4,725E-03 0,03776778 ! glutamine metabolic process GO:0006541 29 18 1,000 4,725E-03 0,03764272 ! positive regulation of secretion GO:0051047 95 59 2,000 4,783E-03 0,03798326 ! protein amino acid autophosphorylation GO:0046777 141 60 2,000 5,014E-03 0,03968464 ! lipid phosphorylation GO:0046834 35 19 1,000 5,261E-03 0,04150091 ! forelimb morphogenesis GO:0035136 32 19 1,000 5,261E-03 0,04136529 ! neuromuscular junction development GO:0007528 34 19 1,000 5,261E-03 0,04123055 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 5,261E-03 0,04109668 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 1,000 5,261E-03 0,04096368 ! cell-cell junction organization GO:0045216 35 19 1,000 5,261E-03 0,04083154 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 1,000 5,261E-03 0,04070025 ! regulation of mitosis GO:0007088 105 63 2,000 5,746E-03 0,04431284 GO:0051783|regulation of nuclear division, ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 1,000 5,824E-03 0,04476475 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 5,824E-03 0,04462219 ! cellular response to starvation GO:0009267 33 20 1,000 5,824E-03 0,04448053 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 5,824E-03 0,04433977 ! regulation of interleukin-2 production GO:0032663 35 20 1,000 5,824E-03 0,0441999 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 1,000 5,824E-03 0,0440609 ! actin filament-based movement GO:0030048 43 20 1,000 5,824E-03 0,04392278 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 5,824E-03 0,04378552 ! positive regulation of cell motion GO:0051272 146 64 2,000 6,004E-03 0,04500037 ! glycerol metabolic process GO:0006071 34 21 1,000 6,412E-03 0,04791337 ! hindlimb morphogenesis GO:0035137 43 21 1,000 6,412E-03 0,04776503 ! axis specification GO:0009798 38 21 1,000 6,412E-03 0,04761761 ! cell structure disassembly during apoptosis GO:0006921 30 21 1,000 6,412E-03 0,04747109 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 1,000 6,412E-03 0,04732547 ! DNA modification GO:0006304 34 21 1,000 6,412E-03 0,04718075 ! positive regulation of locomotion GO:0040017 39 21 1,000 6,412E-03 0,0470369 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 1,000 6,412E-03 0,04689393 ! actin filament organization GO:0007015 148 66 2,000 6,539E-03 0,04767682 ! positive regulation of protein catabolic process GO:0045732 38 22 1,000 7,027E-03 0,05107923 ! regulation of chemotaxis GO:0050920 40 22 1,000 7,027E-03 0,05092538 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 7,027E-03 0,05077245 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 7,027E-03 0,05062043 ! positive regulation of cytoskeleton organization GO:0051495 48 22 1,000 7,027E-03 0,05046933 ! positive regulation of adaptive immune response GO:0002821 39 22 1,000 7,027E-03 0,05031912 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 7,027E-03 0,05016981 ! positive regulation of B cell activation GO:0050871 38 22 1,000 7,027E-03 0,05002138 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 1,000 7,027E-03 0,04987382 ! protein stabilization GO:0050821 39 22 1,000 7,027E-03 0,04972713 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 7,667E-03 0,05409964 ! regulation of cell-matrix adhesion GO:0001952 78 23 1,000 7,667E-03 0,05394145 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 47 23 1,000 7,667E-03 0,05378419 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 7,667E-03 0,05362784 ! regulation of viral reproduction GO:0050792 38 23 1,000 7,667E-03 0,05347239 ! platelet activation GO:0030168 37 23 1,000 7,667E-03 0,05331785 ! regulation of caspase activity GO:0043281 122 72 2,000 8,312E-03 0,0576343 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 2,000 8,312E-03 0,05746868 ! protein import into nucleus, translocation GO:0000060 46 24 1,000 8,333E-03 0,05744873 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 8,333E-03 0,0572846 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 1,000 8,333E-03 0,05712139 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 35 24 1,000 8,333E-03 0,05695911 ! regulation of behavior GO:0050795 43 24 1,000 8,333E-03 0,05679776 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 1,000 8,333E-03 0,05663731 GO:0002708|positive regulation of lymphocyte mediated immunity, ! pallium development GO:0021543 49 24 1,000 8,333E-03 0,05647777 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 8,333E-03 0,05631912 ! protein tetramerization GO:0051262 52 24 1,000 8,333E-03 0,05616137 ! regulation of endopeptidase activity GO:0052548 125 74 2,000 8,96E-03 0,06021559 ! myelination GO:0042552 45 25 1,000 9,024E-03 0,06047738 ! dicarboxylic acid metabolic process GO:0043648 42 25 1,000 9,024E-03 0,06030939 ! vasculogenesis GO:0001570 46 25 1,000 9,024E-03 0,06014233 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 9,024E-03 0,05997619 ! negative regulation of DNA replication GO:0008156 42 25 1,000 9,024E-03 0,05981096 ! receptor metabolic process GO:0043112 46 25 1,000 9,024E-03 0,05964665 ! chromosome condensation GO:0030261 45 25 1,000 9,024E-03 0,05948323 ! response to starvation GO:0042594 42 25 1,000 9,024E-03 0,05932071 ! response to endoplasmic reticulum stress GO:0034976 43 25 1,000 9,024E-03 0,05915907 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 9,024E-03 0,05899832 ! cellular response to nutrient levels GO:0031669 41 25 1,000 9,024E-03 0,05883843 ! telomere organization GO:0032200 43 25 1,000 9,024E-03 0,05867941 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 1,000 9,024E-03 0,05852124 GO:0060606|tube closure, ! liver development GO:0001889 53 25 1,000 9,024E-03 0,05836392 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 9,294E-03 0,05995209 ! initiation of viral infection GO:0019059 57 26 1,000 9,739E-03 0,06265389 ! tube lumen formation GO:0035148 50 26 1,000 9,739E-03 0,06248681 ! insulin receptor signaling pathway GO:0008286 64 26 1,000 9,739E-03 0,06232063 ! regulation of endothelial cell proliferation GO:0001936 57 26 1,000 9,739E-03 0,06215532 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 9,739E-03 0,06199089 ! cellular response to oxidative stress GO:0034599 39 26 1,000 9,739E-03 0,06182732 ! somatic diversification of immune receptors GO:0002200 56 26 1,000 9,739E-03 0,06166462 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 9,985E-03 0,06305569 ! protein oligomerization GO:0051259 139 78 2,000 0,01034144 0,06513482 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 0,01047897 0,06582874 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 0,01047897 0,06565731 ! mitochondrial membrane organization GO:0007006 57 27 1,000 0,01047897 0,06548677 ! response to toxin GO:0009636 47 27 1,000 0,01047897 0,06531711 ! primary neural tube formation GO:0014020 51 27 1,000 0,01047897 0,06514834 ! negative regulation of neuron differentiation GO:0045665 42 27 1,000 0,01047897 0,06498043 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 2,000 0,01070506 0,06621173 ! regulation of peptidase activity GO:0052547 134 79 2,000 0,01070506 0,06604195 ! dendrite development GO:0016358 59 28 1,000 0,01124281 0,06918212 ! ER-nuclear signaling pathway GO:0006984 48 28 1,000 0,01124281 0,06900563 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 0,01124281 0,06883005 ! cell-substrate adhesion GO:0031589 171 81 2,000 0,01145431 0,0699469 ! response to drug GO:0042493 143 82 2,000 0,01184 0,07211912 ! cellular response to hormone stimulus GO:0032870 167 82 2,000 0,01184 0,071937 ! regulation of pH GO:0006885 43 29 1,000 0,01203044 0,07290994 ! regulation of production of molecular mediator of immune response GO:0002700 61 29 1,000 0,01203044 0,07272675 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 1,000 0,01203044 0,07254448 ! tissue homeostasis GO:0001894 48 29 1,000 0,01203044 0,07236311 GO:0048871|multicellular organismal homeostasis, ! cell junction assembly GO:0034329 78 30 1,000 0,01284157 0,0770494 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,01284157 0,07685773 ! ensheathment of neurons GO:0007272 57 30 1,000 0,01284157 0,07666702 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 0,01284157 0,07647725 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,01304159 0,0774767 GO:0002696|positive regulation of leukocyte activation, ! erythrocyte differentiation GO:0030218 55 31 1,000 0,01367589 0,08104481 ! myeloid leukocyte activation GO:0002274 49 31 1,000 0,01367589 0,08084568 ! positive regulation of immune effector process GO:0002699 67 31 1,000 0,01367589 0,08064753 ! positive regulation of protein modification process GO:0031401 136 88 2,000 0,01431036 0,08418269 ! regulation of axonogenesis GO:0050770 75 32 1,000 0,01453313 0,08528463 ! peripheral nervous system development GO:0007422 64 32 1,000 0,01453313 0,08507713 ! positive regulation of catabolic process GO:0009896 64 32 1,000 0,01453313 0,08487063 ! DNA damage checkpoint GO:0000077 71 33 1,000 0,01541298 0,08979089 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,01541298 0,089574 ! xenobiotic metabolic process GO:0006805 51 34 1,000 0,01631518 0,09458873 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01631518 0,09436135 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 1,000 0,01631518 0,09413506 ! placenta development GO:0001890 53 34 1,000 0,01631518 0,09390986 ! regulation of muscle development GO:0048634 70 35 1,000 0,01723943 0,09899301 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,01723943 0,09875731 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,01723943 0,09852273 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 0,01723943 0,09828927 ! telencephalon development GO:0021537 68 35 1,000 0,01723943 0,0980569 ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 0,01723943 0,09782564 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,01723943 0,09759546 ! regulation of microtubule-based process GO:0032886 78 35 1,000 0,01723943 0,09736636 ! neural tube formation GO:0001841 67 35 1,000 0,01723943 0,09713834 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 1,000 0,01818546 0,10222947 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! cell junction organization GO:0034330 86 36 1,000 0,01818546 0,10199117 ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,01818546 0,10175398 ! regulation of proteolysis GO:0030162 72 36 1,000 0,01818546 0,10151789 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 1,000 0,01818546 0,1012829 ! protein ubiquitination GO:0016567 217 97 2,000 0,01852391 0,1029296 ! tissue remodeling GO:0048771 76 37 1,000 0,01915298 0,1061799 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,01915298 0,10593581 ! cellular response to insulin stimulus GO:0032869 82 37 1,000 0,01915298 0,10569284 ! regulation of neuron projection development GO:0010975 91 38 1,000 0,02014173 0,11089474 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 0,02014173 0,11064156 ! erythrocyte homeostasis GO:0034101 64 38 1,000 0,02014173 0,11038953 ! embryonic epithelial tube formation GO:0001838 72 38 1,000 0,02014173 0,11013864 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 0,02014173 0,1098889 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 1,000 0,02014173 0,10964028 ! mammary gland development GO:0030879 86 39 1,000 0,02115143 0,1148766 ! learning GO:0007612 77 39 1,000 0,02115143 0,11461787 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 1,000 0,02115143 0,1143603 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,02115143 0,11410389 ! response to xenobiotic stimulus GO:0009410 57 39 1,000 0,02115143 0,11384862 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,0221818 0,11912817 ! cellular amide metabolic process GO:0043603 67 41 1,000 0,02323259 0,12449359 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 1,000 0,02323259 0,12421693 ! T cell differentiation GO:0030217 81 41 1,000 0,02323259 0,12394151 ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 0,02323259 0,1236673 ! response to reactive oxygen species GO:0000302 67 42 1,000 0,02430353 0,12908231 ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,02430353 0,12879799 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 1,000 0,02430353 0,12851492 ! regulation of leukocyte mediated immunity GO:0002703 79 42 1,000 0,02430353 0,12823309 ! neuron migration GO:0001764 79 42 1,000 0,02430353 0,12795249 ! regulation of myeloid cell differentiation GO:0045637 98 42 1,000 0,02430353 0,12767312 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,02539435 0,13311284 ! striated muscle cell differentiation GO:0051146 82 43 1,000 0,02539435 0,13282347 ! positive regulation of response to external stimulus GO:0032103 77 43 1,000 0,02539435 0,13253535 ! neural tube development GO:0021915 77 43 1,000 0,02539435 0,13224847 ! biopolymer methylation GO:0043414 84 44 1,000 0,02650478 0,13773329 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 1,000 0,02650478 0,13743645 ! regulation of actin filament polymerization GO:0030833 87 45 1,000 0,02763459 0,1429867 ! cell growth GO:0016049 84 45 1,000 0,02763459 0,14267986 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02839511 0,14629257 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02839511 0,14597998 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02839511 0,14566872 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02839511 0,14535879 ! neuron fate determination GO:0048664 7 5 0,000 0,02839511 0,14505017 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02839511 0,14474286 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02839511 0,14443685 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,02839511 0,14413213 ! polyol transport GO:0015791 12 5 0,000 0,02839511 0,1438287 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02839511 0,14352654 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02839511 0,14322564 ! response to superoxide GO:0000303 10 5 0,000 0,02839511 0,14292601 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02839511 0,14262762 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02839511 0,14233048 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02839511 0,14203458 ! female meiosis GO:0007143 7 5 0,000 0,02839511 0,1417399 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02839511 0,14144644 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02839511 0,1411542 ! cobalt ion transport GO:0006824 11 5 0,000 0,02839511 0,14086316 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02839511 0,14057331 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02839511 0,14028466 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02839511 0,13999719 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02839511 0,1397109 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02839511 0,13942578 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,02839511 0,13914181 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02839511 0,13885901 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02839511 0,13857735 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02839511 0,13829682 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02839511 0,13801744 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02839511 0,13773918 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02839511 0,13746203 ! negative chemotaxis GO:0050919 14 5 0,000 0,02839511 0,13718601 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02839511 0,13691108 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02839511 0,13663726 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02839511 0,13636453 ! behavioral response to pain GO:0048266 9 5 0,000 0,02839511 0,13609289 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02839511 0,13582233 ! Notch receptor processing GO:0007220 8 5 0,000 0,02839511 0,13555284 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02839511 0,13528442 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02839511 0,13501706 ! micturition GO:0060073 9 5 0,000 0,02839511 0,13475075 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02839511 0,13448549 ! copulation GO:0007620 9 5 0,000 0,02839511 0,13422128 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02839511 0,1339581 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02839511 0,13369595 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02839511 0,13343483 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02839511 0,13317472 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02839511 0,13291562 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02839511 0,13265754 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02839511 0,13240045 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02839511 0,13214435 ! grooming behavior GO:0007625 6 5 0,000 0,02839511 0,13188925 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02839511 0,13163513 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02839511 0,13138198 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02839511 0,13112981 ! response to protozoan GO:0001562 10 5 0,000 0,02839511 0,1308786 ! positive regulation of glycolysis GO:0045821 14 5 0,000 0,02839511 0,13062836 ! lymph vessel development GO:0001945 10 5 0,000 0,02839511 0,13037907 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02839511 0,13013073 ! endochondral ossification GO:0001958 16 5 0,000 0,02839511 0,12988333 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02839511 0,12963687 ! parathyroid gland development GO:0060017 13 5 0,000 0,02839511 0,12939135 ! anagen GO:0042640 6 5 0,000 0,02839511 0,12914675 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02839511 0,12890308 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02839511 0,12866032 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02839511 0,12841848 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02839511 0,12817754 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02839511 0,12793751 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,02839511 0,12769838 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,02839511 0,12746013 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02839511 0,12722278 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02839511 0,1269863 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02839511 0,12675071 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,02839511 0,12651598 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02839511 0,12628213 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02839511 0,12604913 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 8 5 0,000 0,02839511 0,125817 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02839511 0,12558572 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02839511 0,12535529 ! histidine catabolic process GO:0006548 6 5 0,000 0,02839511 0,1251257 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02839511 0,12489695 ! microvillus organization GO:0032528 7 5 0,000 0,02839511 0,12466903 GO:0030033|microvillus assembly, ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,02839511 0,12444195 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02839511 0,12421569 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02839511 0,12399026 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02839511 0,12376564 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02839511 0,12354183 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02839511 0,12331883 ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02839511 0,12309663 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02839511 0,12287524 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02839511 0,12265463 ! muscle cell migration GO:0014812 8 5 0,000 0,02839511 0,12243482 ! mitochondrial fission GO:0000266 8 5 0,000 0,02839511 0,1222158 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02839511 0,12199756 ! mRNA transcription GO:0009299 9 5 0,000 0,02839511 0,12178009 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02839511 0,1215634 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02839511 0,12134748 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02839511 0,12113232 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02839511 0,12091793 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02839511 0,1207043 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02839511 0,12049141 ! response to food GO:0032094 6 5 0,000 0,02839511 0,12027928 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02839511 0,12006789 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02839511 0,11985725 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02839511 0,11964734 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02839511 0,11943817 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,02839511 0,11922972 ! forebrain neuron development GO:0021884 13 5 0,000 0,02839511 0,11902201 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02839511 0,11881501 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,02839511 0,11860873 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02839511 0,11840317 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02839511 0,11819832 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02839511 0,11799418 ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,02839511 0,11779074 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02839511 0,11758801 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02839511 0,11738596 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02839511 0,11718462 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02839511 0,11698396 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02839511 0,11678398 ! basic amino acid transport GO:0015802 11 5 0,000 0,02839511 0,11658469 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02839511 0,11638608 ! depyrimidination GO:0045008 10 5 0,000 0,02839511 0,11618815 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02839511 0,11599088 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02839511 0,11579429 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02839511 0,11559836 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02839511 0,11540309 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,02839511 0,11520848 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02839511 0,11501453 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02839511 0,11482123 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02839511 0,11462858 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02839511 0,11443657 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02839511 0,1142452 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02839511 0,11405448 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02839511 0,11386439 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02839511 0,11367493 ! response to arsenic GO:0046685 10 5 0,000 0,02839511 0,1134861 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,02839511 0,1132979 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02839511 0,11311032 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02839511 0,11292336 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,02839511 0,11273701 ! response to cadmium ion GO:0046686 7 5 0,000 0,02839511 0,11255129 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02839511 0,11236617 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02839511 0,11218166 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02839511 0,11199776 ! decidualization GO:0046697 11 5 0,000 0,02839511 0,11181445 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02839511 0,11163175 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02839511 0,11144964 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02839511 0,11126813 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02839511 0,11108721 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02839511 0,11090687 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02839511 0,11072712 ! neural tube patterning GO:0021532 7 5 0,000 0,02839511 0,11054795 ! embryonic cleavage GO:0040016 6 5 0,000 0,02839511 0,11036936 ! peroxisome fission GO:0016559 5 5 0,000 0,02839511 0,11019134 ! histone demethylation GO:0016577 10 5 0,000 0,02839511 0,1100139 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02839511 0,10983703 ! mitotic recombination GO:0006312 9 5 0,000 0,02839511 0,10966072 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02839511 0,10948499 ! metaphase plate congression GO:0051310 7 5 0,000 0,02839511 0,10930981 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02839511 0,10913519 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02839511 0,10896113 ! enteric nervous system development GO:0048484 8 5 0,000 0,02839511 0,10878763 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02839511 0,10861468 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02839511 0,10844227 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02839511 0,10827041 ! muscle cell proliferation GO:0033002 11 5 0,000 0,02839511 0,1080991 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02839511 0,10792833 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,02839511 0,10775809 ! plasminogen activation GO:0031639 5 5 0,000 0,02839511 0,1075884 ! B cell homeostasis GO:0001782 13 5 0,000 0,02839511 0,10741923 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02839511 0,1072506 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02839511 0,10708249 ! metaphase GO:0051323 8 5 0,000 0,02839511 0,10691492 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02839511 0,10674786 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02839511 0,10658133 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02839511 0,10641531 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02839511 0,10624982 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02839511 0,10608483 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02839511 0,10592036 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02839511 0,10575639 ! response to redox state GO:0051775 5 5 0,000 0,02839511 0,10559294 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02839511 0,10542999 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02839511 0,10526754 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02839511 0,10510559 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02839511 0,10494413 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02839511 0,10478318 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02839511 0,10462271 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02839511 0,10446274 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02839511 0,10430325 ! striatum development GO:0021756 9 5 0,000 0,02839511 0,10414425 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,02839511 0,10398574 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02839511 0,10382771 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02839511 0,10367015 ! glial cell migration GO:0008347 11 5 0,000 0,02839511 0,10351308 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02839511 0,10335648 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,02839511 0,10320035 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02839511 0,10304469 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02839511 0,1028895 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02839511 0,10273478 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02839511 0,10258053 ! neuroprotection GO:0043526 6 5 0,000 0,02839511 0,10242673 ! neural plate development GO:0001840 8 5 0,000 0,02839511 0,1022734 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02839511 0,10212052 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02839511 0,10196811 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02839511 0,10181614 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02839511 0,10166463 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02839511 0,10151357 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02839511 0,10136295 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02839511 0,10121279 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02839511 0,10106306 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02839511 0,10091378 ! spindle assembly GO:0051225 6 5 0,000 0,02839511 0,10076494 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02839511 0,10061654 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02839511 0,10046858 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02839511 0,10032104 ! drug metabolic process GO:0017144 6 5 0,000 0,02839511 0,10017395 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02839511 0,10002728 ! organ regeneration GO:0031100 7 5 0,000 0,02839511 0,09988104 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02839511 0,09973523 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02839511 0,09958984 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02839511 0,09944488 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 0,0287835 0,10065856 ! response to insulin stimulus GO:0032868 95 46 1,000 0,0287835 0,10051247 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,0287835 0,1003668 ! endosome transport GO:0016197 108 47 1,000 0,02995126 0,10428759 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,02995126 0,10413689 ! regulation of adaptive immune response GO:0002819 84 47 1,000 0,02995126 0,10398662 ! methylation GO:0032259 90 47 1,000 0,02995126 0,10383678 ! protein homooligomerization GO:0051260 76 47 1,000 0,02995126 0,10368738 ! positive regulation of cell cycle GO:0045787 89 48 1,000 0,03113762 0,10763954 ! mitochondrial transport GO:0006839 82 48 1,000 0,03113762 0,1074851 ! cellular component disassembly GO:0022411 86 48 1,000 0,03113762 0,10733111 ! morphogenesis of embryonic epithelium GO:0016331 91 48 1,000 0,03113762 0,10717756 ! regulation of action potential GO:0001508 95 49 1,000 0,03234234 0,11116523 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,03234234 0,11100665 ! induction of apoptosis by extracellular signals GO:0008624 89 49 1,000 0,03234234 0,11084852 ! response to temperature stimulus GO:0009266 76 49 1,000 0,03234234 0,11069084 ! DNA-dependent DNA replication GO:0006261 74 49 1,000 0,03234234 0,11053361 ! regulation of gene expression, epigenetic GO:0040029 105 50 1,000 0,03356515 0,11455002 ! positive regulation of cytokine production GO:0001819 86 50 1,000 0,03356515 0,11438777 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03397719 0,11562818 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03397719 0,11546486 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,03397719 0,115302 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03397719 0,11513961 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03397719 0,11497767 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,03397719 0,11481618 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,03397719 0,11465515 ! sleep GO:0030431 13 6 0,000 0,03397719 0,11449457 ! response to oxygen radical GO:0000305 11 6 0,000 0,03397719 0,11433443 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,03397719 0,11417475 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,03397719 0,11401551 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,03397719 0,11385671 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03397719 0,11369836 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03397719 0,11354044 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,03397719 0,11338297 ! forebrain regionalization GO:0021871 8 6 0,000 0,03397719 0,11322593 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03397719 0,11306932 ! male meiosis GO:0007140 7 6 0,000 0,03397719 0,11291315 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03397719 0,11275741 ! response to zinc ion GO:0010043 9 6 0,000 0,03397719 0,11260209 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03397719 0,11244721 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,03397719 0,11229275 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03397719 0,11213871 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03397719 0,1119851 ! malate metabolic process GO:0006108 11 6 0,000 0,03397719 0,1118319 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,03397719 0,11167913 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,03397719 0,11152677 ! protein refolding GO:0042026 15 6 0,000 0,03397719 0,11137482 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03397719 0,11122329 ! opsonization GO:0008228 8 6 0,000 0,03397719 0,11107217 ! mating behavior GO:0007617 7 6 0,000 0,03397719 0,11092147 ! erythrocyte maturation GO:0043249 7 6 0,000 0,03397719 0,11077117 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,03397719 0,11062127 ! equilibrioception GO:0050957 14 6 0,000 0,03397719 0,11047178 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,03397719 0,1103227 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,03397719 0,11017402 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03397719 0,11002573 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,03397719 0,10987785 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03397719 0,10973036 ! response to interferon-gamma GO:0034341 15 6 0,000 0,03397719 0,10958327 ! toxin metabolic process GO:0009404 11 6 0,000 0,03397719 0,10943657 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03397719 0,10929027 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03397719 0,10914435 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,03397719 0,10899883 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,03397719 0,10885369 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,03397719 0,10870894 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,03397719 0,10856457 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,03397719 0,10842058 ! thymic T cell selection GO:0045061 12 6 0,000 0,03397719 0,10827698 ! protein lipoylation GO:0009249 10 6 0,000 0,03397719 0,10813376 ! cysteine metabolic process GO:0006534 10 6 0,000 0,03397719 0,10799091 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03397719 0,10784844 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03397719 0,10770635 ! glutamate catabolic process GO:0006538 10 6 0,000 0,03397719 0,10756463 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,03397719 0,10742328 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03397719 0,10728231 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,03397719 0,1071417 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,03397719 0,10700147 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03397719 0,10686159 ! hyperosmotic response GO:0006972 9 6 0,000 0,03397719 0,10672209 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,03397719 0,10658295 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,03397719 0,10644417 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03397719 0,10630575 ! urea metabolic process GO:0019627 7 6 0,000 0,03397719 0,10616769 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03397719 0,10602999 ! neutrophil activation GO:0042119 8 6 0,000 0,03397719 0,10589264 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03397719 0,10575565 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,03397719 0,10561902 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03397719 0,10548274 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03397719 0,1053468 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03397719 0,10521122 ! neuron apoptosis GO:0051402 9 6 0,000 0,03397719 0,10507599 ! nucleoside salvage GO:0043174 9 6 0,000 0,03397719 0,1049411 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,03397719 0,10480656 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03397719 0,10467237 ! T cell mediated immunity GO:0002456 16 6 0,000 0,03397719 0,10453852 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03397719 0,10440501 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,03397719 0,10427184 ! carnitine transport GO:0015879 10 6 0,000 0,03397719 0,10413901 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,03397719 0,10400651 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03397719 0,10387436 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,03397719 0,10374254 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,03397719 0,10361105 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,03397719 0,1034799 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03397719 0,10334908 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,03397719 0,10321859 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,03397719 0,10308842 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,03397719 0,10295859 ! establishment of spindle localization GO:0051293 12 6 0,000 0,03397719 0,10282908 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,03397719 0,1026999 ! monocyte differentiation GO:0030224 12 6 0,000 0,03397719 0,10257104 ! neural nucleus development GO:0048857 14 6 0,000 0,03397719 0,10244251 ! astrocyte development GO:0014002 15 6 0,000 0,03397719 0,10231429 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,03397719 0,1021864 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03397719 0,10205883 ! interaction with symbiont GO:0051702 13 6 0,000 0,03397719 0,10193157 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03397719 0,10180463 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03397719 0,10167801 ! response to copper ion GO:0046688 10 6 0,000 0,03397719 0,1015517 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,03397719 0,10142571 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03397719 0,10130002 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03397719 0,10117465 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03397719 0,10104959 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,03397719 0,10092484 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03397719 0,10080039 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,03397719 0,10067626 ! hair follicle maturation GO:0048820 7 6 0,000 0,03397719 0,10055242 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03397719 0,10042889 ! Schwann cell development GO:0014044 15 6 0,000 0,03397719 0,10030567 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,03397719 0,10018274 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03397719 0,10006012 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,03397719 0,0999378 ! subpallium development GO:0021544 10 6 0,000 0,03397719 0,09981578 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,03397719 0,09969405 ! histone ubiquitination GO:0016574 8 6 0,000 0,03397719 0,09957262 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,03397719 0,09945148 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03397719 0,09933064 ! G2 phase GO:0051319 16 6 0,000 0,03397719 0,0992101 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,03397719 0,09908984 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03397719 0,09896988 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,03397719 0,09885021 ! membrane to membrane docking GO:0022614 14 6 0,000 0,03397719 0,09873082 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03397719 0,09861172 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,03397719 0,09849292 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03397719 0,09837439 ! receptor internalization GO:0031623 10 6 0,000 0,03397719 0,09825615 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,03397719 0,0981382 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,03397719 0,09802053 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03397719 0,09790314 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,03397719 0,09778603 ! protein deubiquitination GO:0016579 14 6 0,000 0,03397719 0,0976692 ! protein destabilization GO:0031648 9 6 0,000 0,03397719 0,09755265 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03397719 0,09743638 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,03397719 0,09732038 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03397719 0,09720466 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,03397719 0,09708922 ! progesterone metabolic process GO:0042448 10 6 0,000 0,03397719 0,09697404 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,03397719 0,09685915 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,03397719 0,09674452 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,03397719 0,09663017 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,03397719 0,09651608 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03397719 0,09640226 ! determination of adult lifespan GO:0008340 15 6 0,000 0,03397719 0,09628872 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,03397719 0,09617544 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,03397719 0,09606242 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03397719 0,09594967 ! catecholamine transport GO:0051937 9 6 0,000 0,03397719 0,09583719 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,03397719 0,09572496 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03397719 0,09561301 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03397719 0,09550131 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,03397719 0,09538987 ! maternal placenta development GO:0001893 12 6 0,000 0,03397719 0,09527869 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,03397719 0,09516778 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03397719 0,09505712 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,03397719 0,09494671 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03397719 0,09483657 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,03397719 0,09472667 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,03397719 0,09461704 ! viral infectious cycle GO:0019058 99 51 1,000 0,03480583 0,09681252 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 0,03480583 0,09670073 ! regulation of angiogenesis GO:0045765 114 52 1,000 0,03606413 0,10008107 ! positive regulation of growth GO:0045927 90 52 1,000 0,03606413 0,09996577 ! amino acid activation GO:0043038 92 52 1,000 0,03606413 0,09985073 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cartilage development GO:0051216 90 52 1,000 0,03606413 0,09973596 ! synapse organization GO:0050808 85 52 1,000 0,03606413 0,09962146 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 1,000 0,0373398 0,103027 ! cell maturation GO:0048469 100 53 1,000 0,0373398 0,10290899 ! regulation of neuron apoptosis GO:0043523 100 53 1,000 0,0373398 0,10279125 ! regulation of protein polymerization GO:0032271 103 53 1,000 0,0373398 0,10267377 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,0386326 0,10610735 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,0386326 0,10598636 ! glutamine family amino acid metabolic process GO:0009064 78 54 1,000 0,0386326 0,10586565 ! tRNA transcription GO:0009304 14 7 0,000 0,03952739 0,10819442 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03952739 0,10807147 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03952739 0,1079488 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03952739 0,10782641 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03952739 0,10770429 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03952739 0,10758246 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03952739 0,10746089 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03952739 0,10733961 ! prostate gland development GO:0030850 13 7 0,000 0,03952739 0,10721859 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03952739 0,10709785 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03952739 0,10697738 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03952739 0,10685718 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03952739 0,10673725 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03952739 0,10661759 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03952739 0,1064982 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03952739 0,10637907 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03952739 0,10626021 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03952739 0,10614162 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03952739 0,10602329 ! glycolipid transport GO:0046836 10 7 0,000 0,03952739 0,10590522 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03952739 0,10578742 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,03952739 0,10566988 ! N-terminal protein amino acid acetylation GO:0006474 13 7 0,000 0,03952739 0,1055526 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03952739 0,10543558 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03952739 0,10531882 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03952739 0,10520231 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03952739 0,10508607 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03952739 0,10497008 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03952739 0,10485435 ! pericardium development GO:0060039 14 7 0,000 0,03952739 0,10473887 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03952739 0,10462364 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03952739 0,10450867 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03952739 0,10439395 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03952739 0,10427949 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03952739 0,10416527 ! lipoprotein transport GO:0042953 14 7 0,000 0,03952739 0,1040513 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03952739 0,10393759 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03952739 0,10382412 ! rhythmic behavior GO:0007622 15 7 0,000 0,03952739 0,1037109 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03952739 0,10359792 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03952739 0,10348519 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03952739 0,10337271 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03952739 0,10326047 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03952739 0,10314847 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03952739 0,10303672 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03952739 0,10292521 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03952739 0,10281394 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03952739 0,10270291 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03952739 0,10259212 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03952739 0,10248156 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03952739 0,10237125 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03952739 0,10226117 ! spinal cord patterning GO:0021511 13 7 0,000 0,03952739 0,10215133 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,03952739 0,10204173 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03952739 0,10193236 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03952739 0,10182322 ! adrenal gland development GO:0030325 17 7 0,000 0,03952739 0,10171432 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03952739 0,10160565 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03952739 0,10149722 ! ovulation GO:0030728 9 7 0,000 0,03952739 0,10138901 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03952739 0,10128103 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03952739 0,10117329 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03952739 0,10106577 ! microtubule nucleation GO:0007020 20 7 0,000 0,03952739 0,10095848 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03952739 0,10085142 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03952739 0,10074459 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,03952739 0,10063798 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03952739 0,1005316 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03952739 0,10042544 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03952739 0,10031951 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03952739 0,10021379 ! galactose metabolic process GO:0006012 13 7 0,000 0,03952739 0,10010831 ! vesicle fusion GO:0006906 17 7 0,000 0,03952739 0,10000304 ! response to dietary excess GO:0002021 8 7 0,000 0,03952739 0,09989799 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03952739 0,09979317 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03952739 0,09968856 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03952739 0,09958418 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03952739 0,09948001 ! organ growth GO:0035265 15 7 0,000 0,03952739 0,09937606 ! purine salvage GO:0043101 10 7 0,000 0,03952739 0,09927233 ! nucleoside transport GO:0015858 8 7 0,000 0,03952739 0,09916881 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03952739 0,09906551 ! parturition GO:0007567 14 7 0,000 0,03952739 0,09896243 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,03952739 0,09885955 ! rRNA modification GO:0000154 14 7 0,000 0,03952739 0,0987569 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03952739 0,09865445 ! spindle checkpoint GO:0031577 15 7 0,000 0,03952739 0,09855222 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,03952739 0,0984502 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03952739 0,09834839 ! macrophage differentiation GO:0030225 11 7 0,000 0,03952739 0,09824679 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03952739 0,0981454 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03952739 0,09804422 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,03952739 0,09794325 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03952739 0,09784248 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03952739 0,09774192 ! fibrinolysis GO:0042730 10 7 0,000 0,03952739 0,09764157 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 0,000 0,03952739 0,09754143 ! eating behavior GO:0042755 7 7 0,000 0,03952739 0,09744149 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03952739 0,09734175 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03952739 0,09724222 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03952739 0,09714289 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03952739 0,09704377 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03952739 0,09694484 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03952739 0,09684612 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,03952739 0,0967476 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03952739 0,09664928 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03952739 0,09655116 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03952739 0,09645324 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03952739 0,09635551 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03952739 0,09625799 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03952739 0,09616066 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03952739 0,09606353 ! regulation of meiosis GO:0040020 12 7 0,000 0,03952739 0,09596659 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03952739 0,09586985 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,03952739 0,0957733 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03952739 0,09567695 ! oxygen homeostasis GO:0032364 12 7 0,000 0,03952739 0,09558079 ! transcription termination GO:0006353 13 7 0,000 0,03952739 0,09548483 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,03952739 0,09538906 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03952739 0,09529348 ! anaphase GO:0051322 17 7 0,000 0,03952739 0,09519809 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,03952739 0,09510289 ! axonal fasciculation GO:0007413 18 7 0,000 0,03952739 0,09500788 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,03952739 0,09491306 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03952739 0,09481844 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,03952739 0,09472399 ! diuresis GO:0030146 12 7 0,000 0,03952739 0,09462974 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03952739 0,09453568 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03952739 0,0944418 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03952739 0,09434811 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03952739 0,0942546 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03952739 0,09416128 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03952739 0,09406814 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03952739 0,09397519 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03952739 0,09388242 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03952739 0,09378983 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03952739 0,09369743 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03952739 0,09360521 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03952739 0,09351317 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03952739 0,09342131 ! lymph node development GO:0048535 10 7 0,000 0,03952739 0,09332963 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,03952739 0,09323813 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03952739 0,09314681 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,03952739 0,09305567 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03952739 0,0929647 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03952739 0,09287392 ! adult feeding behavior GO:0008343 9 7 0,000 0,03952739 0,09278331 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03952739 0,09269288 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03952739 0,09260262 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03952739 0,09251254 ! muscle adaptation GO:0043500 14 7 0,000 0,03952739 0,09242263 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03952739 0,0923329 ! retina homeostasis GO:0001895 12 7 0,000 0,03952739 0,09224335 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03952739 0,09215396 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03952739 0,09206475 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,03952739 0,09197572 ! protein prenylation GO:0018342 18 7 0,000 0,03952739 0,09188685 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,03952739 0,09179816 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,03952739 0,09170963 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03952739 0,09162128 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,03994231 0,09249393 ! regulation of multicellular organism growth GO:0040014 85 55 1,000 0,03994231 0,09240499 ! regulation of actin filament length GO:0030832 105 56 1,000 0,04126868 0,09538179 ! nucleotide-excision repair GO:0006289 83 56 1,000 0,04126868 0,09529025 ! positive regulation of organelle organization GO:0010638 100 56 1,000 0,04126868 0,09519889 ! regulation of bone remodeling GO:0046850 137 57 1,000 0,04261149 0,09820233 ! lipid modification GO:0030258 97 57 1,000 0,04261149 0,09810836 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,04261149 0,09801456 ! regulation of tissue remodeling GO:0034103 140 58 1,000 0,04397049 0,10104395 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,04397049 0,10094753 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,04504588 0,10331781 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,04504588 0,10321941 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,04504588 0,1031212 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,04504588 0,10302318 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,04504588 0,10292534 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04504588 0,10282769 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04504588 0,10273022 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,04504588 0,10263294 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,04504588 0,10253584 ! meiotic prophase I GO:0007128 13 8 0,000 0,04504588 0,10243892 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04504588 0,10234219 ! oligopeptide transport GO:0006857 15 8 0,000 0,04504588 0,10224564 ! UTP metabolic process GO:0046051 8 8 0,000 0,04504588 0,10214927 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,04504588 0,10205309 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,04504588 0,10195708 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,04504588 0,10186126 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04504588 0,10176562 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04504588 0,10167015 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,04504588 0,10157486 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,04504588 0,10147976 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,04504588 0,10138483 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04504588 0,10129007 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04504588 0,1011955 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,04504588 0,1011011 ! reflex GO:0060004 16 8 0,000 0,04504588 0,10100688 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,04504588 0,10091283 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,04504588 0,10081896 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04504588 0,10072526 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,04504588 0,10063174 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,04504588 0,10053839 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,04504588 0,10044521 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04504588 0,1003522 ! pigment granule organization GO:0048753 16 8 0,000 0,04504588 0,10025937 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,04504588 0,10016671 ! astrocyte differentiation GO:0048708 18 8 0,000 0,04504588 0,10007422 ! histidine metabolic process GO:0006547 16 8 0,000 0,04504588 0,0999819 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04504588 0,09988975 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,04504588 0,09979777 ! glycine catabolic process GO:0006546 13 8 0,000 0,04504588 0,09970596 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,04504588 0,09961432 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,04504588 0,09952285 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,04504588 0,09943154 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,04504588 0,0993404 ! melanin metabolic process GO:0006582 15 8 0,000 0,04504588 0,09924943 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,04504588 0,09915863 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04504588 0,09906799 ! macrophage activation GO:0042116 12 8 0,000 0,04504588 0,09897752 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04504588 0,09888721 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,04504588 0,09879706 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,04504588 0,09870709 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,04504588 0,09861727 ! osteoblast development GO:0002076 16 8 0,000 0,04504588 0,09852762 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,04504588 0,09843813 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,04504588 0,0983488 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,04504588 0,09825964 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,04504588 0,09817063 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,04504588 0,09808179 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04504588 0,09799311 ! response to UV-B GO:0010224 16 8 0,000 0,04504588 0,09790459 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,04504588 0,09781623 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04504588 0,09772803 ! intermediate filament organization GO:0045109 12 8 0,000 0,04504588 0,09763998 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,04504588 0,0975521 ! cellular extravasation GO:0045123 12 8 0,000 0,04504588 0,09746437 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,04504588 0,0973768 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,04504588 0,09728939 ! response to antibiotic GO:0046677 11 8 0,000 0,04504588 0,09720213 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,04504588 0,09711504 ! response to tropane GO:0014073 15 8 0,000 0,04504588 0,09702809 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,04504588 0,09694131 ! melanosome transport GO:0032402 13 8 0,000 0,04504588 0,09685467 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,04504588 0,0967682 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04504588 0,09668187 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,04504588 0,0965957 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,04504588 0,09650969 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,04504588 0,09642383 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04504588 0,09633812 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04504588 0,09625256 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,04504588 0,09616715 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04504588 0,0960819 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04504588 0,09599679 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,04504588 0,09591184 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,04504588 0,09582704 ! intracellular lipid transport GO:0032365 13 8 0,000 0,04504588 0,09574239 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04504588 0,09565788 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04504588 0,09557353 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,04504588 0,09548932 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,04504588 0,09540526 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04504588 0,09532135 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,04504588 0,09523759 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,04504588 0,09515398 ! hormone catabolic process GO:0042447 17 8 0,000 0,04504588 0,09507051 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04504588 0,09498719 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,04504588 0,09490401 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,04504588 0,09482098 ! ATP catabolic process GO:0006200 11 8 0,000 0,04504588 0,09473809 ! blastocyst growth GO:0001832 19 8 0,000 0,04504588 0,09465535 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04504588 0,09457276 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04504588 0,09449031 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,04504588 0,094408 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04504588 0,09432583 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04504588 0,09424381 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,04504588 0,09416193 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,04504588 0,09408019 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,04504588 0,0939986 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,04504588 0,09391714 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,04504588 0,09383583 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,04504588 0,09375465 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04504588 0,09367362 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,04504588 0,09359273 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04504588 0,09351198 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04504588 0,09343136 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,04504588 0,09335089 ! regulation of cellular component size GO:0032535 109 59 1,000 0,04534548 0,0938909 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,04534548 0,09381017 ! DNA catabolic process GO:0006308 86 59 1,000 0,04534548 0,09372957 ! integrin-mediated signaling pathway GO:0007229 135 59 1,000 0,04534548 0,09364912 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,04673621 0,09643853 ! camera-type eye development GO:0043010 116 60 1,000 0,04673621 0,0963559 ! regulation of protein complex assembly GO:0043254 117 61 1,000 0,04814247 0,0991702 ! mesoderm development GO:0007498 119 61 1,000 0,04814247 0,09908536 ! response to peptide hormone stimulus GO:0043434 122 61 1,000 0,04814247 0,09900068 ! viral reproductive process GO:0022415 126 62 1,000 0,04956404 0,10183695 ! regulation of homeostatic process GO:0032844 134 62 1,000 0,04956404 0,10175006 ! regulation of developmental growth GO:0048638 15 9 0,000 0,05053284 0,10365049 ! axon extension GO:0048675 15 9 0,000 0,05053284 0,1035622 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,05053284 0,10347406 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,05053284 0,10338607 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,05053284 0,10329823 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,05053284 0,10321054 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05053284 0,103123 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,05053284 0,10303561 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,05053284 0,10294837 ! phosphate transport GO:0006817 19 9 0,000 0,05053284 0,10286127 ! reproductive behavior GO:0019098 19 9 0,000 0,05053284 0,10277432 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05053284 0,10268752 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,05053284 0,10260086 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05053284 0,10251435 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,05053284 0,10242799 ! GTP metabolic process GO:0046039 9 9 0,000 0,05053284 0,10234177 ! RNA methylation GO:0001510 15 9 0,000 0,05053284 0,10225569 ! elastic fiber assembly GO:0048251 15 9 0,000 0,05053284 0,10216977 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,05053284 0,10208398 ! artery development GO:0060840 24 9 0,000 0,05053284 0,10199834 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,05053284 0,10191284 ! regulation of glycolysis GO:0006110 21 9 0,000 0,05053284 0,10182749 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,05053284 0,10174228 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,05053284 0,10165721 ! chemosensory behavior GO:0007635 20 9 0,000 0,05053284 0,10157228 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,05053284 0,1014875 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,05053284 0,10140285 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05053284 0,10131835 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,05053284 0,10123399 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,05053284 0,10114977 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,05053284 0,10106569 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05053284 0,10098174 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05053284 0,10089794 ! protein targeting to ER GO:0045047 22 9 0,000 0,05053284 0,10081428 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,05053284 0,10073075 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,05053284 0,10064737 ! T cell selection GO:0045058 23 9 0,000 0,05053284 0,10056412 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,05053284 0,10048101 ! endosome organization GO:0007032 17 9 0,000 0,05053284 0,10039804 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05053284 0,1003152 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05053284 0,1002325 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05053284 0,10014993 ! mannose metabolic process GO:0006013 13 9 0,000 0,05053284 0,10006751 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,05053284 0,09998521 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,05053284 0,09990306 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,05053284 0,09982104 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,05053284 0,09973915 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05053284 0,09965739 ! ruffle organization GO:0031529 15 9 0,000 0,05053284 0,09957577 ! retinol metabolic process GO:0042572 18 9 0,000 0,05053284 0,09949429 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,05053284 0,09941294 ! behavioral fear response GO:0001662 22 9 0,000 0,05053284 0,09933172 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,05053284 0,09925063 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,05053284 0,09916967 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,05053284 0,09908885 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,05053284 0,09900816 ! oligodendrocyte development GO:0014003 10 9 0,000 0,05053284 0,0989276 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,05053284 0,09884717 ! segment specification GO:0007379 13 9 0,000 0,05053284 0,09876687 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05053284 0,09868671 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,05053284 0,09860667 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05053284 0,09852676 ! response to amine stimulus GO:0014075 13 9 0,000 0,05053284 0,09844698 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05053284 0,09836733 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,05053284 0,09828781 ! erythrocyte development GO:0048821 15 9 0,000 0,05053284 0,09820842 ! gas homeostasis GO:0033483 16 9 0,000 0,05053284 0,09812915 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05053284 0,09805002 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,05053284 0,09797101 ! renal water homeostasis GO:0003091 14 9 0,000 0,05053284 0,09789213 ! postreplication repair GO:0006301 22 9 0,000 0,05053284 0,09781337 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,05053284 0,09773474 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,05053284 0,09765624 ! icosanoid secretion GO:0032309 15 9 0,000 0,05053284 0,09757787 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,05053284 0,09749962 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05053284 0,09742149 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,05053284 0,09734349 ! regulation of cell division GO:0051302 15 9 0,000 0,05053284 0,09726562 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,05053284 0,09718787 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,05053284 0,09711024 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05053284 0,09703274 ! sterol catabolic process GO:0016127 11 9 0,000 0,05053284 0,09695536 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05053284 0,0968781 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,05053284 0,09680097 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,05053284 0,09672396 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,05053284 0,09664708 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,05053284 0,09657031 ! musculoskeletal movement GO:0050881 14 9 0,000 0,05053284 0,09649367 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,05053284 0,09641715 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,05053284 0,09634075 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05053284 0,09626447 ! purine base metabolic process GO:0006144 21 9 0,000 0,05053284 0,09618831 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,05053284 0,09611227 ! pigment granule transport GO:0051904 17 9 0,000 0,05053284 0,09603635 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,05053284 0,09596055 ! regulation of telomere maintenance GO:0032204 14 9 0,000 0,05053284 0,09588487 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05053284 0,09580931 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05053284 0,09573387 ! mitochondrion localization GO:0051646 15 9 0,000 0,05053284 0,09565855 ! regulation of lipid metabolic process GO:0019216 115 63 1,000 0,05100068 0,09646828 ! myeloid cell differentiation GO:0030099 111 65 1,000 0,05391836 0,10190697 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,05391836 0,10182698 GO:0035113|embryonic appendage morphogenesis, ! developmental maturation GO:0021700 116 66 1,000 0,05539896 0,10454109 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 1,000 0,05539896 0,10445916 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,05598846 0,10548805 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05598846 0,10540551 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,05598846 0,1053231 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05598846 0,10524082 ! synapsis GO:0007129 13 10 0,000 0,05598846 0,10515866 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,05598846 0,10507663 ! N-glycan processing GO:0006491 20 10 0,000 0,05598846 0,10499473 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,05598846 0,10491296 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,05598846 0,10483132 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,05598846 0,1047498 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,05598846 0,10466841 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,05598846 0,10458715 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,05598846 0,10450601 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,05598846 0,10442499 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,05598846 0,10434411 ! androgen metabolic process GO:0008209 17 10 0,000 0,05598846 0,10426335 ! phospholipid efflux GO:0033700 16 10 0,000 0,05598846 0,10418271 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05598846 0,1041022 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,05598846 0,10402181 ! pathogenesis GO:0009405 13 10 0,000 0,05598846 0,10394155 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05598846 0,10386141 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,05598846 0,10378139 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,05598846 0,1037015 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,05598846 0,10362173 ! endoderm development GO:0007492 16 10 0,000 0,05598846 0,10354208 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,05598846 0,10346255 ! arginine catabolic process GO:0006527 13 10 0,000 0,05598846 0,10338315 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05598846 0,10330387 ! proline metabolic process GO:0006560 13 10 0,000 0,05598846 0,10322471 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05598846 0,10314567 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,05598846 0,10306675 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,05598846 0,10298795 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05598846 0,10290928 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,05598846 0,10283072 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,05598846 0,10275228 ! B cell proliferation GO:0042100 18 10 0,000 0,05598846 0,10267397 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,05598846 0,10259577 ! multicellular organism growth GO:0035264 18 10 0,000 0,05598846 0,10251769 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,05598846 0,10243973 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,05598846 0,10236189 ! epithelial cell development GO:0002064 20 10 0,000 0,05598846 0,10228416 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,05598846 0,10220656 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05598846 0,10212907 ! macroautophagy GO:0016236 17 10 0,000 0,05598846 0,1020517 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,05598846 0,10197445 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,05598846 0,10189731 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,05598846 0,10182029 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,05598846 0,10174339 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05598846 0,1016666 ! brain morphogenesis GO:0048854 23 10 0,000 0,05598846 0,10158993 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,05598846 0,10151337 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,05598846 0,10143693 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,05598846 0,1013606 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 0,000 0,05598846 0,10128439 ! blastoderm segmentation GO:0007350 18 10 0,000 0,05598846 0,1012083 ! response to dsRNA GO:0043331 20 10 0,000 0,05598846 0,10113231 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05598846 0,10105645 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05598846 0,10098069 ! melanosome localization GO:0032400 16 10 0,000 0,05598846 0,10090505 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,05598846 0,10082952 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,05598846 0,10075411 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,05598846 0,10067881 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05598846 0,10060362 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,05598846 0,10052854 ! mRNA cleavage GO:0006379 17 10 0,000 0,05598846 0,10045357 ! protein sumoylation GO:0016925 15 10 0,000 0,05598846 0,10037872 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05598846 0,10030398 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05598846 0,10022935 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05598846 0,10015483 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,05598846 0,10008042 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,05598846 0,10000612 ! salivary gland development GO:0007431 27 10 0,000 0,05598846 0,09993193 ! prophase GO:0051324 15 10 0,000 0,05598846 0,09985785 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05598846 0,09978388 ! apical protein localization GO:0045176 15 10 0,000 0,05598846 0,09971002 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,05598846 0,09963627 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,05598846 0,09956263 ! midbrain development GO:0030901 13 10 0,000 0,05598846 0,0994891 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05598846 0,09941568 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,05598846 0,09934236 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,05598846 0,09926915 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,05598846 0,09919606 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05598846 0,09912306 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05598846 0,09905018 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 0,000 0,05598846 0,0989774 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 23 10 0,000 0,05598846 0,09890473 ! oocyte development GO:0048599 17 10 0,000 0,05598846 0,09883217 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05598846 0,09875971 ! blastocyst formation GO:0001825 17 10 0,000 0,05598846 0,09868736 ! cerebellar cortex development GO:0021695 15 10 0,000 0,05598846 0,09861511 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,05598846 0,09854297 ! activation of innate immune response GO:0002218 12 10 0,000 0,05598846 0,09847094 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,05598846 0,09839901 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,05598846 0,09832718 ! response to nicotine GO:0035094 20 10 0,000 0,05598846 0,09825547 ! establishment of cell polarity GO:0030010 16 10 0,000 0,05598846 0,09818385 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,05598846 0,09811234 ! lung development GO:0030324 144 67 1,000 0,05689378 0,09962623 ! chromosome segregation GO:0007059 113 67 1,000 0,05689378 0,09955377 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,05689378 0,09948142 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,05689378 0,09940917 ! adaptive immune response GO:0002250 119 67 1,000 0,05689378 0,09933703 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,05840262 0,10189753 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 134 68 1,000 0,05840262 0,10182369 ! regulation of lipase activity GO:0060191 130 68 1,000 0,05840262 0,10174996 ! cAMP-mediated signaling GO:0019933 120 69 1,000 0,05992526 0,10432718 ! respiratory burst GO:0045730 17 11 0,000 0,06141292 0,10683982 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,06141292 0,10676263 ! neuron fate specification GO:0048665 17 11 0,000 0,06141292 0,10668554 ! telencephalon cell migration GO:0022029 20 11 0,000 0,06141292 0,10660857 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,06141292 0,10653171 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,06141292 0,10645495 ! thyroid gland development GO:0030878 26 11 0,000 0,06141292 0,10637831 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,06141292 0,10630178 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,06141292 0,10622536 ! response to pain GO:0048265 24 11 0,000 0,06141292 0,10614905 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,06141292 0,10607285 ! T cell proliferation GO:0042098 26 11 0,000 0,06141292 0,10599675 ! bone resorption GO:0045453 16 11 0,000 0,06141292 0,10592077 ! peptide or protein amino-terminal blocking GO:0018409 21 11 0,000 0,06141292 0,1058449 ! ventral spinal cord development GO:0021517 21 11 0,000 0,06141292 0,10576913 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06141292 0,10569347 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,06141292 0,10561792 ! melanocyte differentiation GO:0030318 21 11 0,000 0,06141292 0,10554248 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,06141292 0,10546715 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,06141292 0,10539192 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,06141292 0,1053168 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,06141292 0,10524179 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,06141292 0,10516689 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,06141292 0,10509209 ! UV protection GO:0009650 19 11 0,000 0,06141292 0,1050174 ! adult heart development GO:0007512 14 11 0,000 0,06141292 0,10494281 ! chondrocyte differentiation GO:0002062 24 11 0,000 0,06141292 0,10486833 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06141292 0,10479395 ! temperature homeostasis GO:0001659 17 11 0,000 0,06141292 0,10471969 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,06141292 0,10464552 ! negative regulation of ossification GO:0030279 26 11 0,000 0,06141292 0,10457146 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,06141292 0,10449751 ! regulation of organ growth GO:0046620 13 11 0,000 0,06141292 0,10442366 ! pigment granule localization GO:0051875 20 11 0,000 0,06141292 0,10434991 ! vasoconstriction GO:0042310 18 11 0,000 0,06141292 0,10427627 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06141292 0,10420273 ! embryonic axis specification GO:0000578 18 11 0,000 0,06141292 0,1041293 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,06141292 0,10405597 ! snRNA metabolic process GO:0016073 24 11 0,000 0,06141292 0,10398274 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06141292 0,10390962 ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,06141292 0,1038366 ! zymogen activation GO:0031638 15 11 0,000 0,06141292 0,10376368 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,06141292 0,10369086 ! nucleosome positioning GO:0016584 15 11 0,000 0,06141292 0,10361815 ! regulation of isotype switching GO:0045191 22 11 0,000 0,06141292 0,10354553 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,06141292 0,10347302 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,06141292 0,10340061 ! acid secretion GO:0046717 18 11 0,000 0,06141292 0,10332831 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06141292 0,1032561 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,06141292 0,10318399 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,06141292 0,10311199 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,06141292 0,10304008 ! oocyte differentiation GO:0009994 18 11 0,000 0,06141292 0,10296828 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,06141292 0,10289657 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,06141292 0,10282497 ! cholesterol efflux GO:0033344 19 11 0,000 0,06141292 0,10275346 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,06141292 0,10268205 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06141292 0,10261075 ! negative regulation of glucose import GO:0046325 17 11 0,000 0,06141292 0,10253954 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 25 11 0,000 0,06141292 0,10246843 ! embryonic gut development GO:0048566 15 11 0,000 0,06141292 0,10239742 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,06141292 0,10232651 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,06141292 0,10225569 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,06141292 0,10218498 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,06141292 0,10211436 ! defense response to fungus GO:0050832 13 11 0,000 0,06141292 0,10204384 ! developmental induction GO:0031128 19 11 0,000 0,06141292 0,10197341 GO:0045168|cell-cell signaling involved in cell fate specification, ! prepulse inhibition GO:0060134 18 11 0,000 0,06141292 0,10190309 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,06141292 0,10183286 ! sequestering of metal ion GO:0051238 14 11 0,000 0,06141292 0,10176272 ! lamellipodium assembly GO:0030032 20 11 0,000 0,06141292 0,10169269 ! regulation of embryonic development GO:0045995 27 11 0,000 0,06141292 0,10162275 ! nucleus localization GO:0051647 19 11 0,000 0,06141292 0,1015529 ! regulation of synapse organization GO:0050807 17 11 0,000 0,06141292 0,10148316 ! appendage morphogenesis GO:0035107 135 70 1,000 0,0614615 0,10149373 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 150 70 1,000 0,0614615 0,10142412 ! appendage development GO:0048736 136 71 1,000 0,06301113 0,10391006 GO:0060173|limb development, ! regulation of immune effector process GO:0002697 137 71 1,000 0,06301113 0,10383889 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,06457396 0,10634151 ! respiratory system development GO:0060541 153 72 1,000 0,06457396 0,10626877 ! learning or memory GO:0007611 147 73 1,000 0,06614978 0,10878767 ! axon guidance GO:0007411 139 73 1,000 0,06614978 0,10871336 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,06680638 0,10971751 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,06680638 0,10964266 ! positive regulation of cellular catabolic process GO:0031331 31 12 0,000 0,06680638 0,10956792 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,06680638 0,10949329 ! virus-host interaction GO:0019048 29 12 0,000 0,06680638 0,10941875 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,06680638 0,10934432 ! mating GO:0007618 17 12 0,000 0,06680638 0,10926998 ! protein complex disassembly GO:0043241 27 12 0,000 0,06680638 0,10919575 GO:0043624|cellular protein complex disassembly, ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,06680638 0,10912162 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06680638 0,10904759 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,06680638 0,10897366 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,06680638 0,10889983 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,06680638 0,1088261 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,06680638 0,10875247 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,06680638 0,10867894 ! drug transport GO:0015893 16 12 0,000 0,06680638 0,1086055 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,06680638 0,10853217 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,06680638 0,10845894 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,06680638 0,1083858 ! polyamine metabolic process GO:0006595 17 12 0,000 0,06680638 0,10831277 ! focal adhesion formation GO:0048041 35 12 0,000 0,06680638 0,10823983 ! mitotic spindle organization GO:0007052 21 12 0,000 0,06680638 0,10816699 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,06680638 0,10809425 ! forebrain cell migration GO:0021885 21 12 0,000 0,06680638 0,1080216 ! asymmetric protein localization GO:0008105 20 12 0,000 0,06680638 0,10794906 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,06680638 0,10787661 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,06680638 0,10780426 ! entry into host cell GO:0030260 32 12 0,000 0,06680638 0,107732 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 26 12 0,000 0,06680638 0,10765984 ! monoamine transport GO:0015844 18 12 0,000 0,06680638 0,10758778 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06680638 0,10751582 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,06680638 0,10744395 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,06680638 0,10737217 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,06680638 0,1073005 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06680638 0,10722892 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,06680638 0,10715743 ! protein homotetramerization GO:0051289 21 12 0,000 0,06680638 0,10708604 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,06680638 0,10701474 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,06680638 0,10694354 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06680638 0,10687244 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,06680638 0,10680143 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,06680638 0,10673051 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06680638 0,10665969 ! cranial nerve development GO:0021545 20 12 0,000 0,06680638 0,10658896 ! fucose catabolic process GO:0019317 22 12 0,000 0,06680638 0,10651832 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,06680638 0,10644778 ! histone acetylation GO:0016573 26 12 0,000 0,06680638 0,10637733 ! histone methylation GO:0016571 26 12 0,000 0,06680638 0,10630697 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,06680638 0,10623671 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06680638 0,10616654 ! gland morphogenesis GO:0022612 29 12 0,000 0,06680638 0,10609647 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,06680638 0,10602648 ! T cell homeostasis GO:0043029 25 12 0,000 0,06680638 0,10595659 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,06680638 0,10588679 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,06680638 0,10581708 ! spleen development GO:0048536 22 12 0,000 0,06680638 0,10574746 ! digestive tract morphogenesis GO:0048546 26 12 0,000 0,06680638 0,10567794 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,06680638 0,10560851 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,06680638 0,10553916 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,06680638 0,10546991 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,06680638 0,10540075 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,06680638 0,10533168 ! response to cold GO:0009409 17 12 0,000 0,06680638 0,1052627 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,06680638 0,10519381 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,06680638 0,10512501 ! regulation of actin cytoskeleton organization GO:0032956 149 74 1,000 0,06773839 0,10652194 ! eye development GO:0001654 143 74 1,000 0,06773839 0,10645236 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,0693396 0,10889756 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07216903 0,11326724 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,07216903 0,1131934 ! regulation of chemokine production GO:0032642 18 13 0,000 0,07216903 0,11311966 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07216903 0,11304601 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,07216903 0,11297246 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,07216903 0,11289901 ! lipid localization GO:0010876 28 13 0,000 0,07216903 0,11282565 GO:0019915|lipid storage, ! organelle fusion GO:0048284 32 13 0,000 0,07216903 0,11275239 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,07216903 0,11267922 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,07216903 0,11260614 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,07216903 0,11253317 ! endocrine pancreas development GO:0031018 22 13 0,000 0,07216903 0,11246028 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,07216903 0,11238749 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,07216903 0,1123148 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,07216903 0,11224219 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,07216903 0,11216969 ! methionine metabolic process GO:0006555 27 13 0,000 0,07216903 0,11209727 ! plasma membrane organization GO:0007009 24 13 0,000 0,07216903 0,11202495 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,07216903 0,11195272 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,07216903 0,11188059 ! Golgi organization GO:0007030 24 13 0,000 0,07216903 0,11180855 ! cytokine metabolic process GO:0042107 22 13 0,000 0,07216903 0,1117366 ! exocrine system development GO:0035272 32 13 0,000 0,07216903 0,11166474 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 0,000 0,07216903 0,11159298 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 0,000 0,07216903 0,11152131 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,07216903 0,11144973 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,07216903 0,11137824 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,07216903 0,11130684 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,07216903 0,11123554 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,07216903 0,11116432 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,07216903 0,1110932 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,07216903 0,11102217 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07216903 0,11095123 ! ribosome assembly GO:0042255 17 13 0,000 0,07216903 0,11088038 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,07216903 0,11080962 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,07216903 0,11073895 ! chromatin silencing GO:0006342 26 13 0,000 0,07216903 0,11066837 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,07216903 0,11059788 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07216903 0,11052748 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07216903 0,11045717 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,07216903 0,11038695 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,07216903 0,11031682 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07216903 0,11024678 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,07216903 0,11017682 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,07216903 0,11010696 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,07216903 0,11003718 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,07216903 0,1099675 ! embryonic placenta development GO:0001892 23 13 0,000 0,07216903 0,1098979 ! insulin secretion GO:0030073 23 13 0,000 0,07216903 0,10982838 ! actin filament polymerization GO:0030041 24 13 0,000 0,07216903 0,10975896 ! acrosome reaction GO:0007340 18 13 0,000 0,07216903 0,10968962 ! regulation of actin filament-based process GO:0032970 152 77 1,000 0,07257902 0,11024313 ! blood coagulation GO:0007596 146 78 1,000 0,07421685 0,11265978 GO:0050817|coagulation, ! negative regulation of organelle organization GO:0010639 161 78 1,000 0,07421685 0,11258874 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,07586651 0,11501879 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,07586651 0,11494636 ! rRNA transcription GO:0009303 25 14 0,000 0,07750103 0,11734895 ! lactation GO:0007595 26 14 0,000 0,07750103 0,11727515 ! N-terminal protein amino acid modification GO:0031365 27 14 0,000 0,07750103 0,11720144 ! reproductive cellular process GO:0048610 20 14 0,000 0,07750103 0,11712782 ! tRNA modification GO:0006400 20 14 0,000 0,07750103 0,11705429 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,07750103 0,11698086 ! regulation of S phase GO:0033261 23 14 0,000 0,07750103 0,11690751 ! water transport GO:0006833 21 14 0,000 0,07750103 0,11683426 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,07750103 0,11676111 ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,07750103 0,11668804 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,07750103 0,11661506 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,07750103 0,11654218 ! hair follicle morphogenesis GO:0031069 26 14 0,000 0,07750103 0,11646939 ! RNA polyadenylation GO:0043631 30 14 0,000 0,07750103 0,11639668 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,07750103 0,11632407 ! palate development GO:0060021 31 14 0,000 0,07750103 0,11625155 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 0,000 0,07750103 0,11617912 ! regulated secretory pathway GO:0045055 23 14 0,000 0,07750103 0,11610678 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,07750103 0,11603453 ! arginine metabolic process GO:0006525 17 14 0,000 0,07750103 0,11596237 ! regulation of heart rate GO:0002027 24 14 0,000 0,07750103 0,1158903 ! organic alcohol transport GO:0015850 29 14 0,000 0,07750103 0,11581831 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,07750103 0,11574642 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 0,000 0,07750103 0,11567462 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,07750103 0,1156029 ! neutral amino acid transport GO:0015804 26 14 0,000 0,07750103 0,11553128 ! L-amino acid transport GO:0015807 30 14 0,000 0,07750103 0,11545974 ! stem cell development GO:0048864 43 14 0,000 0,07750103 0,1153883 GO:0019827|stem cell maintenance, ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,07750103 0,11531694 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07750103 0,11524566 ! cerebellum development GO:0021549 21 14 0,000 0,07750103 0,11517448 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,07750103 0,11510339 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,07750103 0,11503238 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,07750103 0,11496146 ! cofactor transport GO:0051181 26 14 0,000 0,07750103 0,11489063 ! NADP metabolic process GO:0006739 24 14 0,000 0,07750103 0,11481988 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,07750103 0,11474922 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,07750103 0,11467865 ! intestinal absorption GO:0050892 25 14 0,000 0,07750103 0,11460817 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,07750103 0,11453777 ! oxygen transport GO:0015671 21 14 0,000 0,07750103 0,11446746 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07750103 0,11439723 ! male genitalia development GO:0030539 24 14 0,000 0,07750103 0,11432709 ! regulation of axon extension GO:0030516 37 14 0,000 0,07750103 0,11425704 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,07750103 0,11418707 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,0775278 0,11415661 ! response to metal ion GO:0010038 140 80 1,000 0,0775278 0,11408679 ! protein import into nucleus GO:0006606 158 80 1,000 0,0775278 0,11401705 ! T cell activation GO:0042110 168 81 1,000 0,07920055 0,11640594 ! response to hypoxia GO:0001666 171 81 1,000 0,07920055 0,11633487 ! nuclear import GO:0051170 161 81 1,000 0,07920055 0,11626389 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,08088456 0,11866357 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,08088456 0,11859126 ! response to oxygen levels GO:0070482 176 83 1,000 0,08257966 0,12100284 ! regulation of lyase activity GO:0051339 160 83 1,000 0,08257966 0,12092919 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,08280258 0,12118187 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08280258 0,1211082 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,08280258 0,12103463 ! superoxide anion generation GO:0042554 20 15 0,000 0,08280258 0,12096114 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,08280258 0,12088774 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,08280258 0,12081443 ! copper ion transport GO:0006825 20 15 0,000 0,08280258 0,12074121 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,08280258 0,12066808 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,08280258 0,12059503 ! sulfate transport GO:0008272 23 15 0,000 0,08280258 0,12052208 ! response to cAMP GO:0051591 22 15 0,000 0,08280258 0,12044921 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,08280258 0,12037643 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,08280258 0,12030374 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,08280258 0,12023114 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,08280258 0,12015862 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,08280258 0,12008619 ! response to hexose stimulus GO:0009746 22 15 0,000 0,08280258 0,12001385 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,08280258 0,1199416 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,08280258 0,11986943 ! pituitary gland development GO:0021983 29 15 0,000 0,08280258 0,11979735 ! vesicle coating GO:0006901 33 15 0,000 0,08280258 0,11972536 ! regulation of the force of heart contraction GO:0002026 26 15 0,000 0,08280258 0,11965345 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,08280258 0,11958163 ! regulation of exocytosis GO:0017157 22 15 0,000 0,08280258 0,1195099 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,08280258 0,11943825 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,08280258 0,11936668 ! regulation of vasodilation GO:0042312 26 15 0,000 0,08280258 0,11929521 ! histone deacetylation GO:0016575 20 15 0,000 0,08280258 0,11922382 ! mRNA splice site selection GO:0006376 38 15 0,000 0,08280258 0,11915251 ! tissue regeneration GO:0042246 26 15 0,000 0,08280258 0,11908129 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,08280258 0,11901015 ! water homeostasis GO:0030104 27 15 0,000 0,08280258 0,1189391 ! muscle maintenance GO:0046716 26 15 0,000 0,08280258 0,11886814 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,08280258 0,11879725 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,08280258 0,11872646 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,08280258 0,11865574 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08280258 0,11858512 ! heme biosynthetic process GO:0006783 29 15 0,000 0,08280258 0,11851457 ! cell killing GO:0001906 29 15 0,000 0,08280258 0,11844411 ! lymphocyte homeostasis GO:0002260 30 15 0,000 0,08280258 0,11837373 ! detection of bacterium GO:0016045 18 15 0,000 0,08280258 0,11830344 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,08280258 0,11823323 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,08280258 0,11816311 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,08280258 0,11809306 ! peptide hormone processing GO:0016486 23 15 0,000 0,08280258 0,1180231 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,08428566 0,1200659 ! hemostasis GO:0007599 158 84 1,000 0,08428566 0,11999485 ! regulation of ligase activity GO:0051340 142 84 1,000 0,08428566 0,11992389 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,08428566 0,11985302 ! one-carbon metabolic process GO:0006730 154 85 1,000 0,08600239 0,12222194 ! response to inorganic substance GO:0010035 153 86 1,000 0,08772966 0,12460304 ! tube morphogenesis GO:0035239 176 86 1,000 0,08772966 0,12452953 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,08807382 0,12494435 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,08807382 0,12487073 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,08807382 0,12479719 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,08807382 0,12472373 ! bone remodeling GO:0046849 27 16 0,000 0,08807382 0,12465037 ! filopodium assembly GO:0046847 32 16 0,000 0,08807382 0,12457709 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,08807382 0,12450389 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,08807382 0,12443078 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,08807382 0,12435776 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,08807382 0,12428482 ! startle response GO:0001964 28 16 0,000 0,08807382 0,12421197 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,08807382 0,1241392 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,08807382 0,12406652 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,08807382 0,12399393 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,08807382 0,12392142 ! protein polyubiquitination GO:0000209 34 16 0,000 0,08807382 0,12384899 ! glutamate metabolic process GO:0006536 22 16 0,000 0,08807382 0,12377665 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,08807382 0,12370439 ! response to osmotic stress GO:0006970 25 16 0,000 0,08807382 0,12363222 ! lysosomal transport GO:0007041 26 16 0,000 0,08807382 0,12356013 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08807382 0,12348812 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08807382 0,1234162 ! intermediate filament-based process GO:0045103 32 16 0,000 0,08807382 0,12334437 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,08807382 0,12327261 ! negative regulation of immune response GO:0050777 35 16 0,000 0,08807382 0,12320094 ! axon cargo transport GO:0008088 43 16 0,000 0,08807382 0,12312936 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,08807382 0,12305785 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,08807382 0,12298643 ! DNA replication initiation GO:0006270 27 16 0,000 0,08807382 0,12291509 ! neuron recognition GO:0008038 35 16 0,000 0,08807382 0,12284384 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,08807382 0,12277267 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,08807382 0,12270158 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,08807382 0,12263057 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,08807382 0,12255964 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,08807382 0,1224888 GO:0046466|membrane lipid catabolic process, ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,08807382 0,12241804 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08807382 0,12234736 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,08807382 0,12227676 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,08807382 0,12220624 ! defense response to virus GO:0051607 37 16 0,000 0,08807382 0,12213581 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,0894673 0,12399673 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein localization in nucleus GO:0034504 176 87 1,000 0,0894673 0,12392534 ! gland development GO:0048732 206 88 1,000 0,09121513 0,12627365 ! regulation of neurological system process GO:0031644 148 88 1,000 0,09121513 0,12620104 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,09331495 0,12903206 ! metencephalon development GO:0022037 30 17 0,000 0,09331495 0,12895794 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,09331495 0,12888391 ! negative regulation of cell cycle process GO:0010948 32 17 0,000 0,09331495 0,12880997 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,09331495 0,12873611 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,09331495 0,12866234 ! endothelial cell migration GO:0043542 28 17 0,000 0,09331495 0,12858865 ! inositol metabolic process GO:0006020 28 17 0,000 0,09331495 0,12851504 ! gene silencing by RNA GO:0031047 36 17 0,000 0,09331495 0,12844152 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,09331495 0,12836808 ! glial cell development GO:0021782 27 17 0,000 0,09331495 0,12829473 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,09331495 0,12822146 ! adult walking behavior GO:0007628 33 17 0,000 0,09331495 0,12814828 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,09331495 0,12807517 ! heart looping GO:0001947 30 17 0,000 0,09331495 0,12800215 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,09331495 0,12792922 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,09331495 0,12785637 ! regulation of survival gene product expression GO:0045884 33 17 0,000 0,09331495 0,1277836 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,09331495 0,12771091 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,09331495 0,12763831 ! glycine metabolic process GO:0006544 28 17 0,000 0,09331495 0,12756578 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,09331495 0,12749334 ! NAD metabolic process GO:0019674 29 17 0,000 0,09331495 0,12742099 ! membrane budding GO:0006900 37 17 0,000 0,09331495 0,12734871 ! regulation of protein binding GO:0043393 33 17 0,000 0,09331495 0,12727652 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,09331495 0,12720441 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,09331495 0,12713238 ! genitalia development GO:0048806 30 17 0,000 0,09331495 0,12706043 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,09331495 0,12698856 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,09331495 0,12691678 ! neutrophil chemotaxis GO:0030593 27 17 0,000 0,09331495 0,12684507 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,09331495 0,12677345 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,09331495 0,12670191 ! steroid catabolic process GO:0006706 31 17 0,000 0,09331495 0,12663045 ! gas transport GO:0015669 25 17 0,000 0,09331495 0,12655906 ! organic cation transport GO:0015695 31 17 0,000 0,09331495 0,12648776 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,09331495 0,12641654 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,09331495 0,1263454 ! microspike assembly GO:0030035 36 17 0,000 0,09331495 0,12627434 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,09331495 0,12620336 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,0947407 0,12805962 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,09852613 0,13310156 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,09852613 0,13302687 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,09852613 0,13295226 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,09852613 0,13287773 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,09852613 0,13280329 ! memory GO:0007613 31 18 0,000 0,09852613 0,13272893 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09852613 0,13265466 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,09852613 0,13258047 ! patterning of blood vessels GO:0001569 39 18 0,000 0,09852613 0,13250636 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,09852613 0,13243233 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,09852613 0,13235839 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,09852613 0,13228453 ! epidermis morphogenesis GO:0048730 40 18 0,000 0,09852613 0,13221075 ! response to retinoic acid GO:0032526 26 18 0,000 0,09852613 0,13213706 ! cell-substrate junction assembly GO:0007044 54 18 0,000 0,09852613 0,13206344 ! peptidyl-serine phosphorylation GO:0018105 38 18 0,000 0,09852613 0,13198991 ! response to fungus GO:0009620 21 18 0,000 0,09852613 0,13191646 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,09852613 0,13184309 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,09852613 0,1317698 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,09852613 0,1316966 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,09852613 0,13162347 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,09852613 0,13155043 ! vitamin transport GO:0051180 27 18 0,000 0,09852613 0,13147747 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,09852613 0,13140459 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,09852613 0,13133179 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,09852613 0,13125907 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,09852613 0,13118643 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 0,000 0,09852613 0,13111387 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,09852613 0,13104139 ! nerve development GO:0021675 28 18 0,000 0,09852613 0,13096899 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,09852613 0,13089667 ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,10010125 0,1329159 ! regulation of membrane potential GO:0042391 164 93 1,000 0,10010125 0,13284259 ! negative regulation of multicellular organismal process GO:0051241 166 93 1,000 0,10010125 0,13276936 ! protein secretion GO:0009306 39 19 0,000 0,10370753 0,13747676 ! positive regulation of translation GO:0045727 30 19 0,000 0,10370753 0,13740106 ! negative regulation of defense response GO:0031348 25 19 0,000 0,10370753 0,13732544 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,10370753 0,13724991 ! skin development GO:0043588 36 19 0,000 0,10370753 0,13717445 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,10370753 0,13709908 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,10370753 0,13702379 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,10370753 0,13694859 ! bile acid metabolic process GO:0008206 29 19 0,000 0,10370753 0,13687347 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,10370753 0,13679843 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,10370753 0,13672347 ! cerebral cortex development GO:0021987 36 19 0,000 0,10370753 0,13664859 ! pigmentation during development GO:0048066 41 19 0,000 0,10370753 0,1365738 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,10370753 0,13649909 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,10370753 0,13642445 ! heme metabolic process GO:0042168 36 19 0,000 0,10370753 0,13634991 ! actin filament bundle formation GO:0051017 42 19 0,000 0,10370753 0,13627544 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,10370753 0,13620105 ! plasma membrane fusion GO:0045026 28 19 0,000 0,10370753 0,13612675 ! peptide cross-linking GO:0018149 37 19 0,000 0,10370753 0,13605252 ! protein export from nucleus GO:0006611 36 19 0,000 0,10370753 0,13597838 ! heart process GO:0003015 30 19 0,000 0,10370753 0,13590432 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,10370753 0,13583034 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,10370753 0,13575644 ! visual learning GO:0008542 36 19 0,000 0,10370753 0,13568261 ! cellular pigmentation GO:0033059 36 19 0,000 0,10370753 0,13560887 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,10370753 0,13553521 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,10370753 0,13546163 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,10370753 0,13538813 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,10370753 0,13531471 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,10370753 0,13524137 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,10370753 0,13516811 ! cilium assembly GO:0042384 37 19 0,000 0,10370753 0,13509493 ! peptide hormone secretion GO:0030072 31 19 0,000 0,10370753 0,13502182 ! forebrain development GO:0030900 188 95 1,000 0,10372114 0,13496651 ! regulation of Rho protein signal transduction GO:0035023 213 95 1,000 0,10372114 0,13489355 ! positive regulation of immune response GO:0050778 156 96 1,000 0,10554446 0,13719069 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,10885933 0,14142308 ! positive regulation of ossification GO:0045778 47 20 0,000 0,10885933 0,14134675 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,10885933 0,14127052 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,10885933 0,14119436 ! protein amino acid acetylation GO:0006473 39 20 0,000 0,10885933 0,14111828 ! cAMP metabolic process GO:0046058 36 20 0,000 0,10885933 0,14104229 ! response to vitamin GO:0033273 31 20 0,000 0,10885933 0,14096638 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,10885933 0,14089055 ! regulation of carbohydrate metabolic process GO:0006109 38 20 0,000 0,10885933 0,1408148 GO:0010675|regulation of cellular carbohydrate metabolic process, ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,10885933 0,14073914 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,10885933 0,14066355 ! response to alkaloid GO:0043279 38 20 0,000 0,10885933 0,14058805 ! retinoid metabolic process GO:0001523 32 20 0,000 0,10885933 0,14051263 GO:0016101|diterpenoid metabolic process, ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,10885933 0,14043728 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,10885933 0,14036202 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,10885933 0,14028684 GO:0032392|DNA geometric change, ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,10885933 0,14021174 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,10885933 0,14013672 ! body fluid secretion GO:0007589 31 20 0,000 0,10885933 0,14006178 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,10885933 0,13998692 ! peptide secretion GO:0002790 35 20 0,000 0,10885933 0,13991215 ! stem cell differentiation GO:0048863 53 20 0,000 0,10885933 0,13983745 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,10885933 0,13976283 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,10885933 0,13968829 ! sensory perception of pain GO:0019233 30 20 0,000 0,10885933 0,13961383 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,10885933 0,13953944 ! diencephalon development GO:0021536 34 20 0,000 0,10885933 0,13946514 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,10885933 0,13939092 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,10885933 0,13931677 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,10885933 0,13924271 ! peptidyl-serine modification GO:0018209 43 20 0,000 0,10885933 0,13916872 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,10885933 0,13909481 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,10885933 0,13902099 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,10885933 0,13894723 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,10885933 0,13887356 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,10885933 0,13879997 ! regulation of glucose import GO:0046324 29 20 0,000 0,10885933 0,13872645 GO:0010827|regulation of glucose transport, ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,10885933 0,13865301 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,10885933 0,13857965 ! negative regulation of translation GO:0017148 29 20 0,000 0,10885933 0,13850636 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,10885933 0,13843316 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 1,000 0,11106595 0,14116465 ! regulation of cell killing GO:0031341 42 21 0,000 0,11398167 0,14479404 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,11398167 0,14471763 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,11398167 0,1446413 ! hormone secretion GO:0046879 38 21 0,000 0,11398167 0,14456505 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,11398167 0,14448889 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,11398167 0,1444128 ! ovarian follicle development GO:0001541 35 21 0,000 0,11398167 0,14433679 ! inactivation of MAPK activity GO:0000188 39 21 0,000 0,11398167 0,14426087 ! smooth muscle contraction GO:0006939 46 21 0,000 0,11398167 0,14418502 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,11398167 0,14410925 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,11398167 0,14403357 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,11398167 0,14395796 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,11398167 0,14388243 ! cytolysis GO:0019835 24 21 0,000 0,11398167 0,14380698 ! vasodilation GO:0042311 39 21 0,000 0,11398167 0,14373161 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,11398167 0,14365632 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,11398167 0,1435811 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,11398167 0,14350597 ! oogenesis GO:0048477 36 21 0,000 0,11398167 0,14343091 ! collagen fibril organization GO:0030199 59 21 0,000 0,11398167 0,14335594 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,11398167 0,14328104 ! positive regulation of inflammatory response GO:0050729 35 21 0,000 0,11398167 0,14320622 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,11398167 0,14313148 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,11398167 0,14305681 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,11398167 0,14298223 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,11398167 0,14290772 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,11398167 0,14283329 ! collagen catabolic process GO:0030574 28 21 0,000 0,11398167 0,14275893 ! sperm-egg recognition GO:0035036 21 21 0,000 0,11398167 0,14268466 ! gut development GO:0048565 39 21 0,000 0,11398167 0,14261046 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,11907475 0,14890532 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,11907475 0,14882797 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,11907475 0,1487507 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,11907475 0,14867351 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,11907475 0,14859639 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,11907475 0,14851936 ! regeneration GO:0031099 41 22 0,000 0,11907475 0,14844241 ! keratinization GO:0031424 28 22 0,000 0,11907475 0,14836553 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,11907475 0,14828874 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,11907475 0,14821203 ! sensory perception of taste GO:0050909 28 22 0,000 0,11907475 0,14813539 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,11907475 0,14805883 ! vacuolar transport GO:0007034 36 22 0,000 0,11907475 0,14798236 ! lysosome organization GO:0007040 41 22 0,000 0,11907475 0,14790596 ! central nervous system neuron development GO:0021954 46 22 0,000 0,11907475 0,14782964 ! fucose metabolic process GO:0006004 39 22 0,000 0,11907475 0,1477534 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,11907475 0,14767724 ! ureteric bud development GO:0001657 43 22 0,000 0,11907475 0,14760116 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,11907475 0,14752515 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,11907475 0,14744923 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,11907475 0,14737338 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,11907475 0,14729761 ! sarcomere organization GO:0045214 30 22 0,000 0,11907475 0,14722191 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,11907475 0,1471463 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,11907475 0,14707076 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,11907475 0,1469953 ! positive regulation of DNA replication GO:0045740 43 23 0,000 0,12413871 0,15316808 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,12413871 0,15308957 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,12413871 0,15301114 ! viral genome replication GO:0019079 41 23 0,000 0,12413871 0,15293279 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,12413871 0,15285453 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,12413871 0,15277634 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,12413871 0,15269824 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,12413871 0,15262021 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,12413871 0,15254226 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,12413871 0,15246439 ! visual behavior GO:0007632 42 23 0,000 0,12413871 0,15238661 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,12413871 0,1523089 ! response to ethanol GO:0045471 46 23 0,000 0,12413871 0,15223127 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,12413871 0,15215372 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,12413871 0,15207625 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,12413871 0,15199885 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,12413871 0,15192154 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,12413871 0,15184431 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,12413871 0,15176715 GO:0051693|actin filament capping, ! sex determination GO:0007530 47 23 0,000 0,12413871 0,15169007 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,12413871 0,15161307 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,12413871 0,15153615 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,12413871 0,1514593 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,12413871 0,15138254 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,12413871 0,15130585 ! fatty acid transport GO:0015908 44 23 0,000 0,12413871 0,15122924 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,12413871 0,15115271 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,12413871 0,15107625 ! hormone transport GO:0009914 40 23 0,000 0,12413871 0,15099987 ! cell-cell recognition GO:0009988 25 23 0,000 0,12413871 0,15092357 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,12413871 0,15084735 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,12413871 0,1507712 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,12413871 0,15069513 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,12413871 0,15061914 ! regulation of cellular catabolic process GO:0031329 52 24 0,000 0,12917374 0,1566492 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,12917374 0,15657028 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,12917374 0,15649145 ! vesicle docking GO:0048278 47 24 0,000 0,12917374 0,15641269 ! spinal cord development GO:0021510 47 24 0,000 0,12917374 0,15633401 ! vacuole organization GO:0007033 43 24 0,000 0,12917374 0,15625541 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,12917374 0,15617689 ! digestive system process GO:0022600 39 24 0,000 0,12917374 0,15609845 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,12917374 0,15602009 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,12917374 0,1559418 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,12917374 0,1558636 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,12917374 0,15578547 ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,12917374 0,15570742 ! membrane depolarization GO:0051899 39 24 0,000 0,12917374 0,15562945 ! pentose metabolic process GO:0019321 35 24 0,000 0,12917374 0,15555156 ! leukocyte homeostasis GO:0001776 44 24 0,000 0,12917374 0,15547374 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,12917374 0,15539601 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,12917374 0,15531835 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,12917374 0,15524077 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,12917374 0,15516326 GO:0033013|tetrapyrrole metabolic process, ! regulation of multi-organism process GO:0043900 36 24 0,000 0,12917374 0,15508584 ! regulation of amine transport GO:0051952 40 24 0,000 0,12917374 0,15500849 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,13417998 0,16093571 ! phototransduction GO:0007602 33 25 0,000 0,13417998 0,16085553 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,13417998 0,16077542 GO:0006479|protein amino acid methylation, ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,13417998 0,16069539 ! osteoblast differentiation GO:0001649 60 25 0,000 0,13417998 0,16061544 ! neural crest cell development GO:0014032 54 25 0,000 0,13417998 0,16053558 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,13417998 0,16045579 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,13417998 0,16037608 ! interaction with host GO:0051701 62 25 0,000 0,13417998 0,16029645 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,13417998 0,16021689 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,13417998 0,16013742 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! somitogenesis GO:0001756 43 25 0,000 0,13417998 0,16005803 ! immunoglobulin production GO:0002377 55 25 0,000 0,13417998 0,15997871 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,13417998 0,15989948 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,13417998 0,15982032 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,13417998 0,15974124 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,13417998 0,15966224 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,13915761 0,16550332 ! embryonic pattern specification GO:0009880 44 26 0,000 0,13915761 0,16542155 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,13915761 0,16533986 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,13915761 0,16525825 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,13915761 0,16517672 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,13915761 0,16509528 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,13915761 0,16501391 ! molting cycle process GO:0022404 50 26 0,000 0,13915761 0,16493262 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,13915761 0,16485141 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,13915761 0,16477029 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,13915761 0,16468924 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,13915761 0,16460827 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,13915761 0,16452738 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,13915761 0,16444657 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,13915761 0,16436584 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,13915761 0,16428519 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,13915761 0,16420462 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,13915761 0,16412413 ! blastocyst development GO:0001824 49 26 0,000 0,13915761 0,16404371 ! leukocyte proliferation GO:0070661 52 26 0,000 0,13915761 0,16396338 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,13915761 0,16388312 ! neuron fate commitment GO:0048663 48 27 0,000 0,14410679 0,16962864 ! iron ion transport GO:0006826 59 27 0,000 0,14410679 0,16954569 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,14410679 0,16946283 ! protein amino acid acylation GO:0043543 55 27 0,000 0,14410679 0,16938004 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,14410679 0,16929734 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,14410679 0,16921471 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,14410679 0,16913217 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,14410679 0,1690497 ! autophagy GO:0006914 41 27 0,000 0,14410679 0,16896732 ! male gonad development GO:0008584 44 27 0,000 0,14410679 0,16888502 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,14410679 0,1688028 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,14410679 0,16872065 ! regulation of chromosome organization GO:0033044 42 27 0,000 0,14410679 0,16863859 ! glutathione metabolic process GO:0006749 39 27 0,000 0,14410679 0,16855661 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,14410679 0,16847471 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,14410679 0,16839288 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,14902768 0,17405854 ! circadian rhythm GO:0007623 50 28 0,000 0,14902768 0,17397409 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,14902768 0,17388972 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! negative regulation of protein modification process GO:0031400 60 28 0,000 0,14902768 0,17380543 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,14902768 0,17372122 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,14902768 0,1736371 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,14902768 0,17355305 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,14902768 0,17346909 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,14902768 0,1733852 ! synaptogenesis GO:0007416 42 28 0,000 0,14902768 0,1733014 ! lipid oxidation GO:0034440 43 28 0,000 0,14902768 0,17321768 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,14902768 0,17313404 ! translational initiation GO:0006413 65 29 0,000 0,15392044 0,17873194 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,15392044 0,17864572 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,15392044 0,17855958 ! cellular iron ion homeostasis GO:0006879 51 29 0,000 0,15392044 0,17847353 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,15392044 0,17838756 ! catechol metabolic process GO:0009712 54 29 0,000 0,15392044 0,17830167 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,15392044 0,17821587 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,15392044 0,17813015 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,15392044 0,17804451 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 55 29 0,000 0,15392044 0,17795895 ! cell fate determination GO:0001709 60 29 0,000 0,15392044 0,17787348 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,15392044 0,17778808 ! detection of light stimulus GO:0009583 38 29 0,000 0,15392044 0,17770277 ! negative regulation of neuron apoptosis GO:0043524 56 29 0,000 0,15392044 0,17761754 ! regulation of coagulation GO:0050818 46 29 0,000 0,15392044 0,1775324 ! phenol metabolic process GO:0018958 55 30 0,000 0,15878523 0,18305571 ! zinc ion transport GO:0006829 45 30 0,000 0,15878523 0,18296804 ! membrane docking GO:0022406 61 30 0,000 0,15878523 0,18288045 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,15878523 0,18279295 ! regulation of innate immune response GO:0045088 51 30 0,000 0,15878523 0,18270553 ! acute-phase response GO:0006953 49 30 0,000 0,15878523 0,18261819 ! myofibril assembly GO:0030239 47 30 0,000 0,15878523 0,18253094 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,15878523 0,18244377 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,15878523 0,18235669 ! phospholipid transport GO:0015914 51 30 0,000 0,15878523 0,18226969 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,15878523 0,18218277 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,15878523 0,18209593 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,15878523 0,18200918 ! eye morphogenesis GO:0048592 60 30 0,000 0,15878523 0,1819225 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,16362221 0,18737507 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,16362221 0,18728593 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,16362221 0,18719688 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,16362221 0,1871079 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,16362221 0,18701902 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,16362221 0,18693021 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,16362221 0,18684149 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,16362221 0,18675286 ! ovulation cycle process GO:0022602 49 31 0,000 0,16362221 0,18666431 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,16362221 0,18657584 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,16362221 0,18648746 ! peptide transport GO:0015833 55 31 0,000 0,16362221 0,18639916 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,16362221 0,18631095 ! iron ion homeostasis GO:0055072 54 31 0,000 0,16362221 0,18622281 ! mesoderm formation GO:0001707 69 31 0,000 0,16362221 0,18613477 ! natural killer cell activation GO:0030101 45 31 0,000 0,16362221 0,1860468 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,16362221 0,18595892 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,16362221 0,18587112 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,16843153 0,19124411 ! response to hydrogen peroxide GO:0042542 50 32 0,000 0,16843153 0,1911539 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,16843153 0,19106377 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,16843153 0,19097374 ! cholesterol transport GO:0030301 56 32 0,000 0,16843153 0,19088378 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,16843153 0,19079391 ! spliceosome assembly GO:0000245 67 32 0,000 0,16843153 0,19070413 ! spindle organization GO:0007051 46 32 0,000 0,16843153 0,19061442 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,16843153 0,19052481 ! metanephros development GO:0001656 74 32 0,000 0,16843153 0,19043528 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,16843153 0,19034583 ! response to mechanical stimulus GO:0009612 57 32 0,000 0,16843153 0,19025646 ! muscle cell development GO:0055001 49 32 0,000 0,16843153 0,19016718 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,16843153 0,19007799 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,16843153 0,18998887 ! negative regulation of MAP kinase activity GO:0043407 69 32 0,000 0,16843153 0,18989984 ! ovulation cycle GO:0042698 51 32 0,000 0,16843153 0,1898109 ! BMP signaling pathway GO:0030509 64 32 0,000 0,16843153 0,18972203 ! hindbrain development GO:0030902 61 32 0,000 0,16843153 0,18963325 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,16843153 0,18954456 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,16843153 0,18945594 ! gene silencing GO:0016458 65 32 0,000 0,16843153 0,18936741 ! post-embryonic development GO:0009791 69 33 0,000 0,17321336 0,19465266 ! protein targeting to membrane GO:0006612 68 33 0,000 0,17321336 0,19456179 ! ceramide metabolic process GO:0006672 64 33 0,000 0,17321336 0,194471 ! formation of primary germ layer GO:0001704 72 33 0,000 0,17321336 0,19438029 ! cell fate specification GO:0001708 52 33 0,000 0,17321336 0,19428967 ! sterol transport GO:0015918 57 33 0,000 0,17321336 0,19419914 ! leukocyte chemotaxis GO:0030595 50 33 0,000 0,17321336 0,19410869 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,17321336 0,19401832 ! adult locomotory behavior GO:0008344 59 33 0,000 0,17321336 0,19392804 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,17321336 0,19383784 ! glial cell differentiation GO:0010001 63 34 0,000 0,17796785 0,19906585 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,17796785 0,19897335 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,17796785 0,19888093 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,17796785 0,1987886 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,17796785 0,19869636 ! mismatch repair GO:0006298 46 34 0,000 0,17796785 0,1986042 ! spermatid development GO:0007286 63 34 0,000 0,17796785 0,19851212 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,17796785 0,19842014 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,17796785 0,19832823 ! negative regulation of secretion GO:0051048 63 35 0,000 0,18269516 0,20350211 ! odontogenesis GO:0042476 66 35 0,000 0,18269516 0,20340794 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,18269516 0,20331385 ! female gonad development GO:0008585 58 35 0,000 0,18269516 0,20321986 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,18269516 0,20312595 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 59 35 0,000 0,18269516 0,20303213 ! vesicle localization GO:0051648 64 35 0,000 0,18269516 0,20293839 ! mitotic sister chromatid segregation GO:0000070 57 36 0,000 0,18739544 0,20806341 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,18739544 0,20796744 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,18739544 0,20787156 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,18739544 0,20777577 ! aerobic respiration GO:0009060 55 36 0,000 0,18739544 0,20768006 ! embryonic organ development GO:0048568 57 36 0,000 0,18739544 0,20758445 ! RNA export from nucleus GO:0006405 56 37 0,000 0,19206884 0,21266342 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,19206884 0,2125656 ! meiosis I GO:0007127 65 37 0,000 0,19206884 0,21246787 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,19206884 0,21237023 ! sister chromatid segregation GO:0000819 58 37 0,000 0,19206884 0,21227268 ! actomyosin structure organization GO:0031032 62 37 0,000 0,19206884 0,21217522 ! organic anion transport GO:0015711 68 37 0,000 0,19206884 0,21207784 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,19206884 0,21198056 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,19206884 0,21188337 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,19206884 0,21178626 GO:0015986|ATP synthesis coupled proton transport, ! glycogen metabolic process GO:0005977 61 37 0,000 0,19206884 0,21168925 ! pigment metabolic process GO:0042440 80 37 0,000 0,19206884 0,21159232 ! spermatid differentiation GO:0048515 66 37 0,000 0,19206884 0,21149548 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,19671552 0,21651305 GO:0006956|complement activation, ! positive regulation of DNA metabolic process GO:0051054 72 38 0,000 0,19671552 0,21641405 ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,19671552 0,21631514 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,19671552 0,21621632 ! development of primary female sexual characteristics GO:0046545 67 38 0,000 0,19671552 0,21611759 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 67 38 0,000 0,19671552 0,21601896 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,19671552 0,21592041 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,19671552 0,21582195 ! glucan metabolic process GO:0044042 62 38 0,000 0,19671552 0,21572358 GO:0006073|cellular glucan metabolic process, ! mRNA catabolic process GO:0006402 71 39 0,000 0,20133562 0,22068953 ! ear morphogenesis GO:0042471 60 39 0,000 0,20133562 0,22058903 ! organic ether metabolic process GO:0018904 55 39 0,000 0,20133562 0,22048863 ! development of primary male sexual characteristics GO:0046546 66 39 0,000 0,20133562 0,22038831 ! segmentation GO:0035282 67 39 0,000 0,20133562 0,22028809 ! ion transmembrane transport GO:0034220 66 39 0,000 0,20133562 0,22018796 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,20133562 0,22008792 ! RNA modification GO:0009451 57 39 0,000 0,20133562 0,21998797 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,20592931 0,22490509 ! feeding behavior GO:0007631 59 40 0,000 0,20592931 0,22480305 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,20592931 0,2247011 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,21049673 0,22958075 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,21049673 0,22947672 ! gliogenesis GO:0042063 88 41 0,000 0,21049673 0,22937279 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,21049673 0,22926896 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,21049673 0,22916522 ! female gamete generation GO:0007292 61 41 0,000 0,21049673 0,22906157 ! positive regulation of transcription factor activity GO:0051091 62 42 0,000 0,21503803 0,2338976 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 71 42 0,000 0,21503803 0,23379191 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,21503803 0,23368631 ! regulation of protein secretion GO:0050708 71 42 0,000 0,21503803 0,23358081 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,21955335 0,23837787 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,21955335 0,23827035 ! energy reserve metabolic process GO:0006112 74 43 0,000 0,21955335 0,23816292 ! glucose transport GO:0015758 65 43 0,000 0,21955335 0,23805559 ! striated muscle contraction GO:0006941 77 43 0,000 0,21955335 0,23794836 ! phagocytosis GO:0006909 90 43 0,000 0,21955335 0,23784123 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,21955335 0,23773419 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,22404285 0,24248633 ! hexose transport GO:0008645 67 44 0,000 0,22404285 0,2423773 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,22404285 0,24226836 ! male sex differentiation GO:0046661 76 44 0,000 0,22404285 0,24215953 ! developmental growth GO:0048589 82 44 0,000 0,22404285 0,24205079 ! glycolysis GO:0006096 65 45 0,000 0,22850668 0,2467626 ! leukocyte migration GO:0050900 68 45 0,000 0,22850668 0,24665189 ! detection of stimulus involved in sensory perception GO:0050906 66 45 0,000 0,22850668 0,24654129 ! branching morphogenesis of a tube GO:0048754 97 45 0,000 0,22850668 0,24643078 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,22850668 0,24632037 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,22850668 0,24621006 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,22850668 0,24609985 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,22850668 0,24598974 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,22850668 0,24587973 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,23294497 0,25054341 ! negative regulation of cell migration GO:0030336 115 46 0,000 0,23294497 0,25043146 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,23294497 0,25031961 ! pigmentation GO:0043473 100 46 0,000 0,23294497 0,25020786 ! positive regulation of defense response GO:0031349 76 47 0,000 0,23735788 0,25483403 ! response to calcium ion GO:0051592 81 47 0,000 0,23735788 0,25472036 ! positive regulation of DNA binding GO:0043388 73 47 0,000 0,23735788 0,2546068 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,23735788 0,25449334 ! Notch signaling pathway GO:0007219 96 48 0,000 0,24174554 0,25908231 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,24174554 0,25896695 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,24174554 0,2588517 ! regulation of inflammatory response GO:0050727 75 48 0,000 0,24174554 0,25873655 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,24610811 0,26328862 ! regulation of ion transport GO:0043269 77 49 0,000 0,24610811 0,26317161 ! peptide metabolic process GO:0006518 76 49 0,000 0,24610811 0,26305469 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,24610811 0,26293788 ! endocrine system development GO:0035270 104 49 0,000 0,24610811 0,26282118 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,24610811 0,26270457 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,24610811 0,26258808 ! detection of abiotic stimulus GO:0009582 74 49 0,000 0,24610811 0,26247168 ! neuromuscular process GO:0050905 99 50 0,000 0,25044572 0,26697935 ! regulation of ossification GO:0030278 117 50 0,000 0,25044572 0,26686112 ! inner ear development GO:0048839 79 50 0,000 0,25044572 0,26674299 ! histone modification GO:0016570 91 50 0,000 0,25044572 0,26662496 ! positive regulation of binding GO:0051099 78 51 0,000 0,25475852 0,27109642 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,25475852 0,27097657 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,25475852 0,27085683 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,25475852 0,27073719 ! excretion GO:0007588 83 51 0,000 0,25475852 0,27061766 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,25475852 0,27049823 ! chromatin remodeling GO:0006338 109 51 0,000 0,25475852 0,27037891 ! vesicle organization GO:0016050 107 51 0,000 0,25475852 0,2702597 ! regulation of muscle contraction GO:0006937 81 52 0,000 0,25904664 0,27468763 ! membrane fusion GO:0006944 110 52 0,000 0,25904664 0,27456662 ! covalent chromatin modification GO:0016569 101 52 0,000 0,25904664 0,27444572 ! morphogenesis of a branching structure GO:0001763 111 52 0,000 0,25904664 0,27432492 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,26331024 0,2787173 ! RNA catabolic process GO:0006401 93 53 0,000 0,26331024 0,27859474 ! regulation of translational initiation GO:0006446 82 53 0,000 0,26331024 0,27847228 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,26331024 0,27834993 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,26331024 0,27822768 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,26754944 0,28258294 ! cell recognition GO:0008037 85 54 0,000 0,26754944 0,28245895 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,26754944 0,28233506 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,26754944 0,28221129 ! chloride transport GO:0006821 90 55 0,000 0,27176438 0,2865316 ! glucose catabolic process GO:0006007 82 55 0,000 0,27176438 0,28640609 ! cellular polysaccharide metabolic process GO:0044264 86 55 0,000 0,27176438 0,2862807 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,27176438 0,28615541 ! gastrulation GO:0007369 112 55 0,000 0,27176438 0,28603023 ! heart morphogenesis GO:0003007 97 55 0,000 0,27176438 0,28590516 ! RNA elongation GO:0006354 79 55 0,000 0,27176438 0,28578021 ! nuclear export GO:0051168 97 55 0,000 0,27176438 0,28565536 ! negative regulation of cell motion GO:0051271 134 55 0,000 0,27176438 0,28553062 ! sensory perception of smell GO:0007608 80 56 0,000 0,27595522 0,28980718 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,27595522 0,28968074 ! proton transport GO:0015992 94 56 0,000 0,27595522 0,2895544 ! hydrogen transport GO:0006818 97 58 0,000 0,28426508 0,29814376 ! regulation of endocytosis GO:0030100 91 58 0,000 0,28426508 0,29801385 ! adult behavior GO:0030534 99 58 0,000 0,28426508 0,29788405 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,28838438 0,30206914 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,28838438 0,30193769 ! establishment of organelle localization GO:0051656 109 59 0,000 0,28838438 0,30180636 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,29248011 0,30595963 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,29248011 0,30582666 ! regulation of heart contraction GO:0008016 110 60 0,000 0,29248011 0,30569381 ! negative regulation of response to stimulus GO:0048585 100 60 0,000 0,29248011 0,30556107 ! kidney development GO:0001822 122 60 0,000 0,29248011 0,30542845 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,29655241 0,30954668 ! tRNA processing GO:0008033 89 61 0,000 0,29655241 0,30941244 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,29655241 0,30927832 ! ear development GO:0043583 103 62 0,000 0,3006014 0,31336523 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,3006014 0,31322952 ! gonad development GO:0008406 98 62 0,000 0,3006014 0,31309392 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,30462721 0,31714975 ! detection of external stimulus GO:0009581 91 63 0,000 0,30462721 0,31701258 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,30462721 0,31687552 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,30862999 0,3209005 ! cell redox homeostasis GO:0045454 102 64 0,000 0,30862999 0,32076188 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,30862999 0,32062339 ! multicellular organism reproduction GO:0032504 111 64 0,000 0,30862999 0,32048501 GO:0048609|reproductive process in a multicellular organism, ! single fertilization GO:0007338 75 64 0,000 0,30862999 0,32034675 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,31260986 0,32433779 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,31260986 0,32419799 ! germ cell development GO:0007281 118 65 0,000 0,31260986 0,32405831 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,31656695 0,32801899 ! extracellular matrix organization GO:0030198 133 66 0,000 0,31656695 0,32787778 ! secondary metabolic process GO:0019748 116 66 0,000 0,31656695 0,3277367 ! cell projection assembly GO:0030031 120 66 0,000 0,31656695 0,32759574 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,32050139 0,33152466 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,32050139 0,33138219 ! hexose catabolic process GO:0019320 104 67 0,000 0,32050139 0,33123984 ! activation of immune response GO:0002253 105 67 0,000 0,32050139 0,33109762 ! amino acid transport GO:0006865 125 68 0,000 0,32441332 0,33499504 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,32441332 0,33485133 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,32441332 0,33470774 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,32441332 0,33456427 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,32830285 0,33843044 ! urogenital system development GO:0001655 137 69 0,000 0,32830285 0,3382855 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,32830285 0,33814069 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,32830285 0,337996 ! antigen processing and presentation GO:0019882 104 69 0,000 0,32830285 0,33785143 ! amine catabolic process GO:0009310 117 71 0,000 0,33601524 0,3456403 ! reproductive structure development GO:0048608 113 71 0,000 0,33601524 0,34549259 ! humoral immune response GO:0006959 109 71 0,000 0,33601524 0,34534501 ! acute inflammatory response GO:0002526 113 72 0,000 0,33983836 0,34912515 ! carbohydrate transport GO:0008643 110 72 0,000 0,33983836 0,34897614 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,33983836 0,34882726 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,33983836 0,3486785 ! regulation of blood pressure GO:0008217 125 73 0,000 0,34363959 0,35242832 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,34363959 0,35227816 ! fertilization GO:0009566 90 73 0,000 0,34363959 0,35212813 ! transition metal ion transport GO:0000041 126 74 0,000 0,34741906 0,3558494 ! neurotransmitter transport GO:0006836 123 74 0,000 0,34741906 0,35569798 ! meiosis GO:0007126 121 74 0,000 0,34741906 0,35554668 GO:0051327|M phase of meiotic cell cycle, ! exocytosis GO:0006887 133 74 0,000 0,34741906 0,35539551 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,34741906 0,35524448 ! organelle localization GO:0051640 136 74 0,000 0,34741906 0,35509356 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,35117689 0,35878199 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,35117689 0,35862971 ! meiotic cell cycle GO:0051321 122 75 0,000 0,35117689 0,35847755 ! rhythmic process GO:0048511 128 75 0,000 0,35117689 0,35832553 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,3549132 0,36198439 ! development of primary sexual characteristics GO:0045137 124 76 0,000 0,3549132 0,361831 ! defense response to bacterium GO:0042742 89 76 0,000 0,3549132 0,36167775 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,3549132 0,36152463 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,3549132 0,36137163 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,35862813 0,36499969 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,35862813 0,36484536 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,36232178 0,36844725 ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,36232178 0,36829159 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,36599428 0,3718675 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,36964576 0,37541903 ! inorganic anion transport GO:0015698 138 80 0,000 0,36964576 0,37526063 ! digestion GO:0007586 112 81 0,000 0,37327632 0,37878652 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,37327632 0,37862683 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,3768861 0,38212724 ! response to nutrient GO:0007584 125 82 0,000 0,3768861 0,38196628 ! response to unfolded protein GO:0006986 131 85 0,000 0,38759186 0,39265095 ! nucleosome assembly GO:0006334 122 85 0,000 0,38759186 0,3924857 ! amine biosynthetic process GO:0009309 138 86 0,000 0,39111965 0,39589141 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,39111965 0,39572493 ! chromatin assembly GO:0031497 124 86 0,000 0,39111965 0,39555859 ! amine transport GO:0015837 155 86 0,000 0,39111965 0,39539239 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,39462724 0,39877074 ! cellular respiration GO:0045333 135 88 0,000 0,39811473 0,40212596 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,39811473 0,40195722 ! cellular defense response GO:0006968 114 89 0,000 0,40158225 0,40528813 ! sex differentiation GO:0007548 145 90 0,000 0,40502991 0,40859621 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,40502991 0,40842496 ! sterol metabolic process GO:0016125 152 91 0,000 0,40845782 0,41170905 ! response to protein stimulus GO:0051789 149 91 0,000 0,40845782 0,41153665 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,40845782 0,41136438 ! regulation of defense response GO:0031347 149 92 0,000 0,41186609 0,41462335 ! nucleosome organization GO:0034728 138 92 0,000 0,41186609 0,41444994 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,41186609 0,41427668 ! vitamin metabolic process GO:0006766 139 92 0,000 0,41186609 0,41410356 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,41525484 0,41733632 GO:0010498|proteasomal protein catabolic process, ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,41862417 0,42054687 ! female pregnancy GO:0007565 164 94 0,000 0,41862417 0,42037135 ! transcription initiation GO:0006352 153 94 0,000 0,41862417 0,42019598 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,42530505 0,42672391 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,42530505 0,42654604 ! detection of stimulus GO:0051606 151 96 0,000 0,42530505 0,42636831 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,4286168 0,42950938 ! hormone metabolic process GO:0042445 157 97 0,000 0,4286168 0,42933057 ! response to virus GO:0009615 160 98 0,000 0,43190958 0,4324488 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,43190958 0,43226891 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,43190958 0,43208917 GO:0016054|organic acid catabolic process, ! Golgi vesicle transport GO:0048193 207 99 0,000 0,4351835 0,4351835