pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6693-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 4,000 1,767E-09 4,317E-06 ! polyol catabolic process GO:0046174 9 5 3,000 3,775E-09 4,611E-06 GO:0019405|alditol catabolic process, ! B cell lineage commitment GO:0002326 21 7 3,000 2,62E-08 2,134E-05 ! androgen receptor signaling pathway GO:0030521 81 37 5,000 4,1E-08 2,504E-05 ! interphase of mitotic cell cycle GO:0051329 224 98 7,000 5,53E-08 2,702E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 1,588E-07 6,465E-05 ! cellular carbohydrate catabolic process GO:0044275 17 13 3,000 5,221E-07 1,822E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 5,862E-07 1,79E-04 ! positive regulation of MAP kinase activity GO:0043406 174 93 6,000 6,683E-07 1,814E-04 ! hexose biosynthetic process GO:0019319 53 32 4,000 7,038E-07 1,719E-04 ! negative regulation of DNA binding GO:0043392 67 36 4,000 1,295E-06 2,876E-04 ! monosaccharide biosynthetic process GO:0046364 57 36 4,000 1,295E-06 2,637E-04 ! steroid hormone receptor signaling pathway GO:0030518 146 66 5,000 1,411E-06 2,651E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 5,000 1,837E-06 3,206E-04 ! negative regulation of binding GO:0051100 71 39 4,000 1,953E-06 3,18E-04 ! negative regulation of kinase activity GO:0033673 145 70 5,000 2,001E-06 3,055E-04 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 5,000 2,176E-06 3,127E-04 ! negative regulation of transferase activity GO:0051348 155 74 5,000 2,778E-06 3,77E-04 ! alcohol biosynthetic process GO:0046165 65 42 4,000 2,848E-06 3,662E-04 ! myoblast cell fate commitment GO:0048625 18 6 2,000 2,879E-06 3,516E-04 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 2,000 2,879E-06 3,349E-04 ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 3,437E-06 3,817E-04 ! cytokinesis during cell cycle GO:0033205 14 7 2,000 5,018E-06 5,33E-04 ! G1 phase GO:0051318 44 22 3,000 5,146E-06 5,239E-04 ! activation of JUN kinase activity GO:0007257 47 22 3,000 5,146E-06 5,029E-04 ! JNK cascade GO:0007254 106 49 4,000 6,196E-06 5,822E-04 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 4,000 7,568E-06 6,848E-04 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 7,997E-06 6,978E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 7,997E-06 6,737E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 7,997E-06 6,513E-04 ! alditol metabolic process GO:0019400 44 26 3,000 1,035E-05 8,153E-04 ! positive regulation of JUN kinase activity GO:0043507 59 26 3,000 1,035E-05 7,898E-04 ! response to UV GO:0009411 120 55 4,000 1,102E-05 8,156E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,195E-05 8,586E-04 ! regulation of JUN kinase activity GO:0043506 67 28 3,000 1,405E-05 9,808E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,7E-05 1,154E-03 ! DNA ligation GO:0006266 18 10 2,000 1,7E-05 1,123E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 3,000 1,865E-05 1,199E-03 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of peptide secretion GO:0002793 24 11 2,000 2,329E-05 1,459E-03 ! negative regulation of protein transport GO:0051224 74 33 3,000 2,751E-05 1,68E-03 ! negative regulation of cell growth GO:0030308 142 67 4,000 2,906E-05 1,731E-03 ! activation of MAPK activity GO:0000187 124 67 4,000 2,906E-05 1,69E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 3,093E-05 1,757E-03 ! regulation of hormone metabolic process GO:0032350 28 12 2,000 3,093E-05 1,717E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 3,093E-05 1,679E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of cell size GO:0045792 144 69 4,000 3,352E-05 1,78E-03 ! cytoplasmic sequestering of protein GO:0051220 25 13 2,000 4,005E-05 2,082E-03 ! actin cytoskeleton reorganization GO:0031532 38 15 2,000 6,323E-05 3,218E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 6,323E-05 3,152E-03 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 7,25E-05 3,542E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 2,000 7,752E-05 3,713E-03 ! fructose metabolic process GO:0006000 25 16 2,000 7,752E-05 3,642E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 7,752E-05 3,573E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of growth GO:0045926 168 85 4,000 9,139E-05 4,134E-03 ! myoblast differentiation GO:0045445 50 17 2,000 9,376E-05 4,165E-03 ! B cell differentiation GO:0030183 124 45 3,000 9,532E-05 4,158E-03 ! polyol metabolic process GO:0019751 77 45 3,000 9,532E-05 4,085E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 1,04E-04 4,379E-03 ! negative regulation of protein catabolic process GO:0042177 42 18 2,000 1,121E-04 4,641E-03 ! regulation of JNK cascade GO:0046328 104 47 3,000 1,132E-04 4,608E-03 ! regulation of DNA binding GO:0051101 167 89 4,000 1,137E-04 4,553E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 3,000 1,23E-04 4,845E-03 ! G1 phase of mitotic cell cycle GO:0000080 39 19 2,000 1,326E-04 5,141E-03 ! positive regulation of hormone secretion GO:0046887 35 19 2,000 1,326E-04 5,06E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 1,333E-04 5,011E-03 ! carbohydrate biosynthetic process GO:0016051 158 94 4,000 1,472E-04 5,448E-03 ! pancreas development GO:0031016 40 20 2,000 1,554E-04 5,665E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 1,554E-04 5,581E-03 ! negative regulation of intracellular transport GO:0032387 44 21 2,000 1,805E-04 6,392E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 1,813E-04 6,326E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! apoptotic nuclear changes GO:0030262 34 22 2,000 2,082E-04 7,165E-03 ! cell aging GO:0007569 48 22 2,000 2,082E-04 7,066E-03 ! skeletal muscle fiber development GO:0048741 130 56 3,000 2,246E-04 7,515E-03 ! regulation of protein catabolic process GO:0042176 126 56 3,000 2,246E-04 7,414E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 2,246E-04 7,315E-03 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 2,000 2,385E-04 7,668E-03 ! gluconeogenesis GO:0006094 38 23 2,000 2,385E-04 7,568E-03 ! muscle fiber development GO:0048747 131 57 3,000 2,405E-04 7,533E-03 ! regulation of intracellular transport GO:0032386 108 57 3,000 2,405E-04 7,438E-03 ! aging GO:0007568 112 58 3,000 2,573E-04 7,856E-03 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 2,000 2,716E-04 8,191E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 2,716E-04 8,091E-03 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 2,716E-04 7,993E-03 ! negative regulation of catabolic process GO:0009895 52 24 2,000 2,716E-04 7,898E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,754E-04 7,915E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 2,754E-04 7,823E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 2,754E-04 7,733E-03 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 2,754E-04 7,645E-03 ! valine metabolic process GO:0006573 12 5 1,000 2,754E-04 7,559E-03 ! positive regulation of filopodium assembly GO:0051491 16 5 1,000 2,754E-04 7,475E-03 GO:0051489|regulation of filopodium assembly, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,754E-04 7,393E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 2,754E-04 7,312E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,754E-04 7,234E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 2,754E-04 7,157E-03 ! stem cell division GO:0017145 11 5 1,000 2,754E-04 7,082E-03 GO:0048103|somatic stem cell division, ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 3,074E-04 7,823E-03 ! regulation of insulin secretion GO:0050796 42 25 2,000 3,074E-04 7,742E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 2,000 3,461E-04 8,629E-03 ! pyruvate metabolic process GO:0006090 43 26 2,000 3,461E-04 8,542E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 3,461E-04 8,456E-03 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 3,461E-04 8,373E-03 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of cell development GO:0010721 83 26 2,000 3,461E-04 8,29E-03 GO:0050768|negative regulation of neurogenesis, ! positive regulation of cell projection organization GO:0031346 66 27 2,000 3,879E-04 9,2E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 3,879E-04 9,112E-03 ! positive regulation of actin filament polymerization GO:0030838 11 6 1,000 4,116E-04 9,577E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 1,000 4,116E-04 9,487E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 4,116E-04 9,398E-03 ! regulation of retroviral genome replication GO:0045091 8 6 1,000 4,116E-04 9,311E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 4,116E-04 9,226E-03 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,116E-04 9,142E-03 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 1,000 4,116E-04 9,059E-03 ! positive regulation of cytokine production during immune response GO:0002720 11 6 1,000 4,116E-04 8,979E-03 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 4,116E-04 8,899E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 4,116E-04 8,821E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 4,116E-04 8,744E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 4,328E-04 9,114E-03 ! fat cell differentiation GO:0045444 57 28 2,000 4,328E-04 9,036E-03 ! sperm motility GO:0030317 37 28 2,000 4,328E-04 8,96E-03 ! base-excision repair GO:0006284 41 28 2,000 4,328E-04 8,884E-03 ! regulation of cellular response to stress GO:0080135 142 68 3,000 4,739E-04 9,649E-03 ! regulation of peptide secretion GO:0002791 52 29 2,000 4,808E-04 9,708E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 5,01E-04 0,01003311 ! regulation of B cell activation GO:0050864 55 30 2,000 5,322E-04 0,01056991 ! cell cycle checkpoint GO:0000075 145 71 3,000 5,585E-04 0,01100382 ! regulation of helicase activity GO:0051095 16 7 1,000 5,743E-04 0,01122352 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 5,743E-04 0,01113444 ! mRNA stabilization GO:0048255 18 7 1,000 5,743E-04 0,01104677 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 5,743E-04 0,01096047 ! neuron remodeling GO:0016322 16 7 1,000 5,743E-04 0,0108755 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 5,743E-04 0,01079184 ! T cell lineage commitment GO:0002360 16 7 1,000 5,743E-04 0,01070946 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 5,869E-04 0,01086222 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 5,869E-04 0,01078055 ! B cell activation GO:0042113 179 72 3,000 5,89E-04 0,01073742 ! regulation of MAPKKK cascade GO:0043408 157 72 3,000 5,89E-04 0,01065789 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 2,000 6,451E-04 0,01158827 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 6,451E-04 0,01150368 ! regulation of transcription factor activity GO:0051090 137 75 3,000 6,873E-04 0,0121671 GO:0090046|regulation of transcription regulator activity, ! response to ionizing radiation GO:0010212 74 33 2,000 7,069E-04 0,01242363 ! positive regulation of neurogenesis GO:0050769 72 33 2,000 7,069E-04 0,01233489 ! lymphocyte differentiation GO:0030098 193 76 3,000 7,225E-04 0,01251831 ! regulation of catabolic process GO:0009894 173 77 3,000 7,59E-04 0,01305756 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 7,63E-04 0,01303548 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 1,000 7,63E-04 0,01294496 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 7,63E-04 0,01285568 ! succinate metabolic process GO:0006105 17 8 1,000 7,63E-04 0,01276763 ! T-helper 1 type immune response GO:0042088 12 8 1,000 7,63E-04 0,01268077 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 7,63E-04 0,01259509 ! ER overload response GO:0006983 13 8 1,000 7,63E-04 0,01251056 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 7,63E-04 0,01242716 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 7,63E-04 0,01234486 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 7,63E-04 0,01226364 ! regulation of vascular permeability GO:0043114 12 8 1,000 7,63E-04 0,01218349 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 1,000 7,63E-04 0,01210438 ! DNA topological change GO:0006265 12 8 1,000 7,63E-04 0,01202628 ! mast cell activation GO:0045576 14 8 1,000 7,63E-04 0,01194919 ! multicellular organismal aging GO:0010259 20 8 1,000 7,63E-04 0,01187308 ! response to tumor cell GO:0002347 16 8 1,000 7,63E-04 0,01179794 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 7,63E-04 0,01172373 ! activation of protein kinase activity GO:0032147 170 80 3,000 8,762E-04 0,01337798 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 2,000 9,143E-04 0,01387405 ! positive regulation of cell development GO:0010720 85 36 2,000 9,143E-04 0,01378841 ! muscle cell differentiation GO:0042692 178 81 3,000 9,179E-04 0,0137574 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 9,179E-04 0,01367351 ! DNA synthesis during DNA repair GO:0000731 18 9 1,000 9,776E-04 0,0144747 ! induction of positive chemotaxis GO:0050930 17 9 1,000 9,776E-04 0,0143875 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 9,776E-04 0,01430135 ! receptor clustering GO:0043113 20 9 1,000 9,776E-04 0,01421622 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 9,776E-04 0,0141321 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 9,776E-04 0,01404897 ! pyrimidine base metabolic process GO:0006206 22 9 1,000 9,776E-04 0,01396682 ! microtubule bundle formation GO:0001578 22 9 1,000 9,776E-04 0,01388561 ! negative regulation of cell adhesion GO:0007162 94 37 2,000 9,912E-04 0,01399654 ! maintenance of protein location in cell GO:0032507 89 37 2,000 9,912E-04 0,0139161 ! negative regulation of cell activation GO:0050866 69 37 2,000 9,912E-04 0,01383658 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 1,006E-03 0,01395791 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of JAK-STAT cascade GO:0046427 55 38 2,000 1,072E-03 0,01479532 ! regulation of protein stability GO:0031647 77 38 2,000 1,072E-03 0,0147122 ! negative regulation of transport GO:0051051 164 85 3,000 1,099E-03 0,01499834 ! regulation of neuron differentiation GO:0045664 187 85 3,000 1,099E-03 0,01491502 ! carbohydrate homeostasis GO:0033500 59 39 2,000 1,157E-03 0,01561338 GO:0042593|glucose homeostasis, ! mitochondrion organization GO:0007005 159 87 3,000 1,198E-03 0,01608392 ! alcohol catabolic process GO:0046164 142 87 3,000 1,198E-03 0,01599603 ! regulation of protein transport GO:0051223 165 87 3,000 1,198E-03 0,01590909 GO:0070201|regulation of establishment of protein localization, ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,218E-03 0,0160812 ! lung alveolus development GO:0048286 26 10 1,000 1,218E-03 0,01599474 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 1,218E-03 0,01590921 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,218E-03 0,01582459 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 34 10 1,000 1,218E-03 0,01574086 ! nucleobase biosynthetic process GO:0046112 26 10 1,000 1,218E-03 0,01565801 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,218E-03 0,01557603 ! motor axon guidance GO:0008045 22 10 1,000 1,218E-03 0,01549491 ! regulation of bone resorption GO:0045124 25 10 1,000 1,218E-03 0,01541462 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,218E-03 0,01533517 GO:0045685|regulation of glial cell differentiation, ! positive regulation of viral reproduction GO:0048524 19 10 1,000 1,218E-03 0,01525652 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 1,218E-03 0,01517868 ! nucleus organization GO:0006997 73 40 2,000 1,246E-03 0,0154484 ! regulation of hormone secretion GO:0046883 69 41 2,000 1,339E-03 0,01651967 ! mesenchymal cell development GO:0014031 94 41 2,000 1,339E-03 0,01643666 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 95 41 2,000 1,339E-03 0,01635448 ! regulation of cell cycle process GO:0010564 161 90 3,000 1,359E-03 0,0165139 ! ossification GO:0001503 205 91 3,000 1,415E-03 0,01711743 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 2,000 1,436E-03 0,01728512 ! regulation of T cell differentiation GO:0045580 78 42 2,000 1,436E-03 0,01720038 ! cytokinesis GO:0000910 84 42 2,000 1,436E-03 0,01711648 ! bone development GO:0060348 206 92 3,000 1,474E-03 0,01747632 ! regulation of cell adhesion GO:0030155 241 92 3,000 1,474E-03 0,0173919 ! negative regulation of muscle development GO:0048635 27 11 1,000 1,483E-03 0,01742065 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,483E-03 0,01733729 ! blood vessel remodeling GO:0001974 30 11 1,000 1,483E-03 0,01725474 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,483E-03 0,01717296 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,483E-03 0,01709196 ! negative regulation of proteolysis GO:0045861 25 11 1,000 1,483E-03 0,01701171 ! regulation of intracellular pH GO:0051453 21 11 1,000 1,483E-03 0,01693222 ! positive regulation of T cell mediated immunity GO:0002711 26 11 1,000 1,483E-03 0,01685346 ! nitric oxide metabolic process GO:0046209 17 11 1,000 1,483E-03 0,01677544 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 1,000 1,483E-03 0,01669813 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 25 11 1,000 1,483E-03 0,01662153 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,483E-03 0,01654564 ! lysogeny GO:0030069 22 11 1,000 1,483E-03 0,01647043 GO:0019047|provirus integration, ! regulation of cell morphogenesis GO:0022604 243 93 3,000 1,534E-03 0,01695276 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 1,538E-03 0,01692549 ! regulation of T cell proliferation GO:0042129 80 43 2,000 1,538E-03 0,01684959 ! double-strand break repair GO:0006302 85 44 2,000 1,644E-03 0,01793217 ! regulation of T cell activation GO:0050863 175 96 3,000 1,724E-03 0,01871417 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 1,755E-03 0,01896941 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 1,755E-03 0,01888585 ! maintenance of location in cell GO:0051651 101 45 2,000 1,755E-03 0,01880301 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 1,000 1,774E-03 0,01892175 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 1,774E-03 0,01883948 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 1,774E-03 0,01875792 ! regulation of cell projection assembly GO:0060491 33 12 1,000 1,774E-03 0,01867707 ! hippocampus development GO:0021766 29 12 1,000 1,774E-03 0,01859691 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,774E-03 0,01851744 ! regulation of leukocyte migration GO:0002685 29 12 1,000 1,774E-03 0,01843864 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 1,774E-03 0,01836051 ! localization within membrane GO:0051668 26 12 1,000 1,774E-03 0,01828304 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 1,79E-03 0,0183776 ! regulation of protein localization GO:0032880 188 97 3,000 1,79E-03 0,0183007 ! leukocyte differentiation GO:0002521 232 98 3,000 1,859E-03 0,01892242 ! skeletal muscle tissue development GO:0007519 223 100 3,000 2,001E-03 0,02028898 GO:0060538|skeletal muscle organ development, ! cartilage condensation GO:0001502 22 13 1,000 2,089E-03 0,02108728 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 2,089E-03 0,0210005 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 1,000 2,089E-03 0,02091443 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! response to X-ray GO:0010165 28 13 1,000 2,089E-03 0,02082907 ! regulation of cytokine production during immune response GO:0002718 25 13 1,000 2,089E-03 0,0207444 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,089E-03 0,02066041 ! regulation of mRNA stability GO:0043488 32 13 1,000 2,089E-03 0,0205771 ! regulation of JAK-STAT cascade GO:0046425 76 48 2,000 2,114E-03 0,02074357 ! JAK-STAT cascade GO:0007259 82 48 2,000 2,114E-03 0,0206606 ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 2,243E-03 0,02183571 ! activation of caspase activity GO:0006919 95 50 2,000 2,377E-03 0,02304799 ! non-recombinational repair GO:0000726 29 14 1,000 2,429E-03 0,02345046 GO:0006303|double-strand break repair via nonhomologous end joining, ! cell-cell junction assembly GO:0007043 32 14 1,000 2,429E-03 0,02335814 ! bone mineralization GO:0030282 18 14 1,000 2,429E-03 0,02326654 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 2,429E-03 0,02317565 ! regulation of cellular pH GO:0030641 27 14 1,000 2,429E-03 0,02308547 ! response to gamma radiation GO:0010332 30 14 1,000 2,429E-03 0,02299599 ! regulation of RNA stability GO:0043487 33 14 1,000 2,429E-03 0,02290721 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 2,429E-03 0,0228191 ! positive regulation of protein polymerization GO:0032273 27 14 1,000 2,429E-03 0,02273167 ! regulation of cell projection organization GO:0031344 135 51 2,000 2,516E-03 0,02346292 ! negative regulation of immune system process GO:0002683 101 51 2,000 2,516E-03 0,0233737 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 2,792E-03 0,02584078 ! regulation of mRNA processing GO:0050684 26 15 1,000 2,792E-03 0,02574327 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 2,792E-03 0,02564649 ! G1/S transition checkpoint GO:0031575 37 15 1,000 2,792E-03 0,02555044 ! positive regulation of axonogenesis GO:0050772 33 15 1,000 2,792E-03 0,0254551 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 2,792E-03 0,02536047 ! synaptic transmission, cholinergic GO:0007271 24 15 1,000 2,792E-03 0,02526654 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 2,000 2,809E-03 0,02532037 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 2,000 2,809E-03 0,02522728 ! regulation of cell shape GO:0008360 142 54 2,000 2,963E-03 0,02651077 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 3,18E-03 0,02835577 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,18E-03 0,02825266 ! biomineral formation GO:0031214 22 16 1,000 3,18E-03 0,02815029 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,18E-03 0,02804867 ! positive regulation of caspase activity GO:0043280 108 57 2,000 3,454E-03 0,03035719 GO:0010952|positive regulation of peptidase activity, ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 3,592E-03 0,03145115 ! signal complex assembly GO:0007172 47 17 1,000 3,592E-03 0,03133883 ! activation of MAPKK activity GO:0000186 43 17 1,000 3,592E-03 0,0312273 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 3,592E-03 0,03111657 ! induction of apoptosis via death domain receptors GO:0008625 23 17 1,000 3,592E-03 0,03100661 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 3,592E-03 0,03089743 GO:0031114|regulation of microtubule depolymerization, ! nucleobase metabolic process GO:0009112 43 17 1,000 3,592E-03 0,03078902 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 3,592E-03 0,03068137 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 1,000 3,592E-03 0,03057446 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 3,592E-03 0,0304683 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 3,592E-03 0,03036288 ! positive regulation of cell migration GO:0030335 137 58 2,000 3,629E-03 0,03057014 ! maintenance of location GO:0051235 124 58 2,000 3,629E-03 0,03046509 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 4,027E-03 0,03369009 ! limbic system development GO:0021761 40 18 1,000 4,027E-03 0,03357511 ! regulation of viral genome replication GO:0045069 30 18 1,000 4,027E-03 0,0334609 ! glutamine metabolic process GO:0006541 29 18 1,000 4,027E-03 0,03334748 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 4,027E-03 0,03323482 ! DNA integration GO:0015074 32 18 1,000 4,027E-03 0,03312292 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 4,027E-03 0,03301177 ! positive regulation of secretion GO:0051047 110 61 2,000 4,184E-03 0,03418538 ! neuron maturation GO:0042551 46 19 1,000 4,485E-03 0,03652253 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 4,485E-03 0,03640119 ! neuromuscular junction development GO:0007528 43 19 1,000 4,485E-03 0,03628065 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 4,485E-03 0,03616092 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 1,000 4,485E-03 0,03604197 ! regulation of mitosis GO:0007088 112 63 2,000 4,581E-03 0,03669376 GO:0051783|regulation of nuclear division, ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 4,788E-03 0,03822497 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 4,966E-03 0,03951793 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 4,966E-03 0,03938962 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 4,966E-03 0,03926215 ! forelimb morphogenesis GO:0035136 35 20 1,000 4,966E-03 0,0391355 ! regulation of interleukin-2 production GO:0032663 39 20 1,000 4,966E-03 0,03900966 ! cell-cell junction organization GO:0045216 43 20 1,000 4,966E-03 0,03888463 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 4,966E-03 0,0387604 ! positive regulation of cell motion GO:0051272 157 65 2,000 5E-03 0,03890339 ! lipid phosphorylation GO:0046834 43 21 1,000 5,47E-03 0,04242104 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 5,47E-03 0,0422868 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 5,47E-03 0,0421534 ! actin filament-based movement GO:0030048 47 21 1,000 5,47E-03 0,04202085 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 5,47E-03 0,04188912 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 5,996E-03 0,04577506 ! hindlimb morphogenesis GO:0035137 47 22 1,000 5,996E-03 0,04563246 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 5,996E-03 0,04549074 ! cellular response to starvation GO:0009267 37 22 1,000 5,996E-03 0,0453499 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 5,996E-03 0,04520993 ! positive regulation of locomotion GO:0040017 44 22 1,000 5,996E-03 0,04507083 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of adaptive immune response GO:0002821 42 22 1,000 5,996E-03 0,04493257 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 5,996E-03 0,04479516 ! positive regulation of B cell activation GO:0050871 42 22 1,000 5,996E-03 0,04465859 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 1,000 5,996E-03 0,04452285 ! protein stabilization GO:0050821 41 22 1,000 5,996E-03 0,04438794 ! glycerol metabolic process GO:0006071 40 23 1,000 6,544E-03 0,04830081 ! regulation of chemotaxis GO:0050920 45 23 1,000 6,544E-03 0,04815532 ! axis specification GO:0009798 43 23 1,000 6,544E-03 0,04801071 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 6,544E-03 0,04786697 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 6,544E-03 0,04772408 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 6,544E-03 0,04758204 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 6,544E-03 0,04744085 ! DNA modification GO:0006304 36 23 1,000 6,544E-03 0,04730049 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 6,544E-03 0,04716096 ! actin filament organization GO:0007015 167 72 2,000 6,646E-03 0,04775216 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 1,000 7,114E-03 0,05096971 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 1,000 7,114E-03 0,05082067 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 7,114E-03 0,05067251 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 7,114E-03 0,0505252 ! regulation of viral reproduction GO:0050792 41 24 1,000 7,114E-03 0,05037875 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 7,114E-03 0,05023315 GO:0002708|positive regulation of lymphocyte mediated immunity, ! pallium development GO:0021543 56 24 1,000 7,114E-03 0,05008839 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 7,114E-03 0,04994445 ! platelet activation GO:0030168 41 24 1,000 7,114E-03 0,04980135 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 7,114E-03 0,04965906 ! regulation of caspase activity GO:0043281 136 74 2,000 7,168E-03 0,04989121 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 7,168E-03 0,04974947 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 7,438E-03 0,05147737 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 7,706E-03 0,05318285 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 7,706E-03 0,05303304 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 7,706E-03 0,05288407 ! vasculogenesis GO:0001570 49 25 1,000 7,706E-03 0,05273594 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 7,706E-03 0,05258863 ! negative regulation of DNA replication GO:0008156 45 25 1,000 7,706E-03 0,05244215 ! receptor metabolic process GO:0043112 53 25 1,000 7,706E-03 0,05229647 ! chromosome condensation GO:0030261 48 25 1,000 7,706E-03 0,05215161 ! regulation of behavior GO:0050795 48 25 1,000 7,706E-03 0,05200754 ! liver development GO:0001889 55 25 1,000 7,706E-03 0,05186427 ! protein tetramerization GO:0051262 57 25 1,000 7,706E-03 0,05172179 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 7,996E-03 0,05351945 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 8,284E-03 0,05529543 ! myelination GO:0042552 50 26 1,000 8,32E-03 0,0553819 ! initiation of viral infection GO:0019059 60 26 1,000 8,32E-03 0,0552314 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 8,32E-03 0,05508172 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 8,32E-03 0,05493285 ! somatic diversification of immune receptors GO:0002200 63 26 1,000 8,32E-03 0,05478479 ! telomere organization GO:0032200 46 26 1,000 8,32E-03 0,05463752 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 58 26 1,000 8,32E-03 0,05449103 GO:0060606|tube closure, ! protein oligomerization GO:0051259 149 79 2,000 8,578E-03 0,05603316 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 2,000 8,878E-03 0,05783864 ! tube lumen formation GO:0035148 59 27 1,000 8,954E-03 0,05817914 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 8,954E-03 0,05802482 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 8,954E-03 0,05787132 ! mitochondrial membrane organization GO:0007006 60 27 1,000 8,954E-03 0,05771862 ! response to starvation GO:0042594 47 27 1,000 8,954E-03 0,05756673 ! response to toxin GO:0009636 49 27 1,000 8,954E-03 0,05741564 ! cellular response to oxidative stress GO:0034599 43 27 1,000 8,954E-03 0,05726533 ! cellular response to nutrient levels GO:0031669 45 27 1,000 8,954E-03 0,05711582 ! regulation of peptidase activity GO:0052547 150 82 2,000 9,497E-03 0,06041758 ! cell-substrate adhesion GO:0031589 189 82 2,000 9,497E-03 0,06026065 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 9,61E-03 0,0608206 ! dendrite development GO:0016358 67 28 1,000 9,61E-03 0,06066344 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 9,61E-03 0,06050709 ! response to drug GO:0042493 149 83 2,000 9,815E-03 0,06164072 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01028603 0,06443272 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01028603 0,06426793 ! primary neural tube formation GO:0014020 61 29 1,000 0,01028603 0,06410398 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 0,01028603 0,06394086 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01028603 0,06377858 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01028603 0,06361711 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 0,01047041 0,064594 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,01080738 0,06650483 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01098273 0,06741409 ! tissue homeostasis GO:0001894 50 30 1,000 0,01098273 0,06724513 GO:0048871|multicellular organismal homeostasis, ! cell junction assembly GO:0034329 85 31 1,000 0,01169968 0,07145581 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01169968 0,07127761 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01169968 0,07110031 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01169968 0,07092388 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 1,000 0,01169968 0,07074832 ! positive regulation of immune effector process GO:0002699 78 31 1,000 0,01169968 0,07057364 ! positive regulation of protein modification process GO:0031401 156 90 2,000 0,01221764 0,07351647 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01243665 0,07465048 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,01243665 0,07446751 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01243665 0,07428544 ! regulation of pH GO:0006885 56 33 1,000 0,01319341 0,07861344 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,01319341 0,07842216 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,01319341 0,07823182 ! DNA damage checkpoint GO:0000077 78 35 1,000 0,01476539 0,08734105 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01476539 0,08713008 ! regulation of synaptic plasticity GO:0048167 78 35 1,000 0,01476539 0,08692013 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01476539 0,08671118 ! telencephalon development GO:0021537 81 35 1,000 0,01476539 0,08650324 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01476539 0,0862963 ! placenta development GO:0001890 53 35 1,000 0,01476539 0,08609034 ! regulation of muscle development GO:0048634 82 36 1,000 0,01558016 0,0906246 ! regulation of proteolysis GO:0030162 77 36 1,000 0,01558016 0,09040934 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01558016 0,0901951 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 1,000 0,01558016 0,08998187 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,01641382 0,09457301 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01641382 0,09435048 ! xenobiotic metabolic process GO:0006805 55 37 1,000 0,01641382 0,094129 ! cell junction organization GO:0034330 96 37 1,000 0,01641382 0,09390856 ! tissue remodeling GO:0048771 78 37 1,000 0,01641382 0,09368915 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,01641382 0,09347076 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,01726614 0,09809578 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,01726614 0,09786818 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 0,01726614 0,09764164 ! neural tube formation GO:0001841 79 38 1,000 0,01726614 0,09741614 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,01813692 0,1020933 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,01813692 0,10185861 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,01813692 0,10162498 ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,01813692 0,10139243 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01813692 0,10116094 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,01813692 0,10093051 ! mammary gland development GO:0030879 93 40 1,000 0,01902593 0,10563714 ! learning GO:0007612 82 40 1,000 0,01902593 0,1053976 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,01902593 0,10515915 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,01993296 0,10992373 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01993296 0,10967615 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,01993296 0,10942969 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,01993296 0,10918433 ! T cell differentiation GO:0030217 93 42 1,000 0,02085779 0,11399459 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,02085779 0,11374013 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,02085779 0,11348681 ! response to xenobiotic stimulus GO:0009410 63 42 1,000 0,02085779 0,11323462 ! epithelial cell differentiation GO:0030855 83 43 1,000 0,02180022 0,11808853 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 1,000 0,02180022 0,11782727 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,02180022 0,11756717 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 1,000 0,02180022 0,11730821 ! neuron migration GO:0001764 85 43 1,000 0,02180022 0,11705039 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,02180022 0,1167937 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,02276003 0,12166902 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,02276003 0,12140337 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,02276003 0,12113887 ! biopolymer methylation GO:0043414 91 45 1,000 0,02373701 0,12606417 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 1,000 0,02373701 0,12579071 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,02473096 0,13077434 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,02473096 0,13049189 ! cell growth GO:0016049 90 46 1,000 0,02473096 0,13021066 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,02473096 0,12993064 ! neural tube development GO:0021915 91 47 1,000 0,02574168 0,1349505 ! response to insulin stimulus GO:0032868 98 47 1,000 0,02574168 0,13466152 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02616927 0,13660582 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02616927 0,13631455 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02616927 0,13602452 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02616927 0,13573572 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02616927 0,13544815 ! neuron fate determination GO:0048664 7 5 0,000 0,02616927 0,13516179 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02616927 0,13487664 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02616927 0,13459268 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02616927 0,13430993 ! polyol transport GO:0015791 12 5 0,000 0,02616927 0,13402835 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02616927 0,13374796 ! response to superoxide GO:0000303 10 5 0,000 0,02616927 0,13346874 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02616927 0,13319068 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02616927 0,13291377 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02616927 0,13263802 ! female meiosis GO:0007143 10 5 0,000 0,02616927 0,13236341 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02616927 0,13208993 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02616927 0,13181758 ! hypothalamus development GO:0021854 9 5 0,000 0,02616927 0,13154635 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02616927 0,13127623 ! cobalt ion transport GO:0006824 11 5 0,000 0,02616927 0,13100722 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02616927 0,13073932 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02616927 0,1304725 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02616927 0,13020677 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02616927 0,12994212 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02616927 0,12967855 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02616927 0,12941604 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02616927 0,1291546 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02616927 0,1288942 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02616927 0,12863486 ! transposition GO:0032196 9 5 0,000 0,02616927 0,12837656 ! negative chemotaxis GO:0050919 16 5 0,000 0,02616927 0,12811929 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02616927 0,12786305 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02616927 0,12760783 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02616927 0,12735364 ! behavioral response to pain GO:0048266 10 5 0,000 0,02616927 0,12710045 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02616927 0,12684826 ! Notch receptor processing GO:0007220 11 5 0,000 0,02616927 0,12659708 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02616927 0,12634689 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02616927 0,12609768 ! micturition GO:0060073 9 5 0,000 0,02616927 0,12584946 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02616927 0,12560221 ! copulation GO:0007620 9 5 0,000 0,02616927 0,12535593 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02616927 0,12511062 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02616927 0,12486626 ! bioluminescence GO:0008218 9 5 0,000 0,02616927 0,12462286 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02616927 0,1243804 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02616927 0,12413888 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02616927 0,1238983 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02616927 0,12365866 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02616927 0,12341993 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02616927 0,12318213 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02616927 0,12294524 ! grooming behavior GO:0007625 6 5 0,000 0,02616927 0,12270926 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02616927 0,12247419 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02616927 0,12224001 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02616927 0,12200673 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02616927 0,12177433 ! response to protozoan GO:0001562 13 5 0,000 0,02616927 0,12154282 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02616927 0,12131219 ! lymph vessel development GO:0001945 10 5 0,000 0,02616927 0,12108243 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02616927 0,12085354 ! endochondral ossification GO:0001958 17 5 0,000 0,02616927 0,12062552 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02616927 0,12039835 ! single strand break repair GO:0000012 8 5 0,000 0,02616927 0,12017204 ! parathyroid gland development GO:0060017 14 5 0,000 0,02616927 0,11994658 ! anagen GO:0042640 7 5 0,000 0,02616927 0,11972196 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02616927 0,11949818 ! cytokine secretion GO:0050663 15 5 0,000 0,02616927 0,11927523 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02616927 0,11905312 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02616927 0,11883183 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02616927 0,11861136 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02616927 0,11839171 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02616927 0,11817287 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02616927 0,11795484 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02616927 0,11773762 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02616927 0,11752119 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02616927 0,11730555 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02616927 0,11709071 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02616927 0,11687665 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02616927 0,11666337 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02616927 0,11645087 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02616927 0,11623914 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02616927 0,11602818 ! microvillus organization GO:0032528 8 5 0,000 0,02616927 0,11581798 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02616927 0,11560854 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02616927 0,11539986 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02616927 0,11519194 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02616927 0,11498476 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02616927 0,11477832 ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02616927 0,11457263 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02616927 0,11436767 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02616927 0,11416344 ! muscle cell migration GO:0014812 8 5 0,000 0,02616927 0,11395994 ! mitochondrial fission GO:0000266 8 5 0,000 0,02616927 0,11375716 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02616927 0,11355511 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02616927 0,11335377 ! mRNA transcription GO:0009299 10 5 0,000 0,02616927 0,11315314 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02616927 0,11295322 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02616927 0,11275401 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02616927 0,1125555 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02616927 0,11235769 ! monocyte activation GO:0042117 10 5 0,000 0,02616927 0,11216057 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02616927 0,11196414 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02616927 0,1117684 ! response to food GO:0032094 6 5 0,000 0,02616927 0,11157334 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02616927 0,11137896 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02616927 0,11118526 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02616927 0,11099223 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02616927 0,11079987 ! forebrain neuron development GO:0021884 13 5 0,000 0,02616927 0,11060817 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02616927 0,11041714 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02616927 0,11022677 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02616927 0,11003705 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02616927 0,10984798 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02616927 0,10965956 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02616927 0,10947179 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02616927 0,10928466 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02616927 0,10909817 ! lipid glycosylation GO:0030259 7 5 0,000 0,02616927 0,10891231 ! nucleobase transport GO:0015851 6 5 0,000 0,02616927 0,10872708 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02616927 0,10854249 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02616927 0,10835852 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02616927 0,10817517 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02616927 0,10799244 ! basic amino acid transport GO:0015802 12 5 0,000 0,02616927 0,10781033 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02616927 0,10762883 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02616927 0,10744794 ! actin nucleation GO:0045010 11 5 0,000 0,02616927 0,10726766 ! depurination GO:0045007 5 5 0,000 0,02616927 0,10708798 ! depyrimidination GO:0045008 10 5 0,000 0,02616927 0,1069089 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02616927 0,10673043 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02616927 0,10655254 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02616927 0,10637525 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02616927 0,10619855 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02616927 0,10602243 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,02616927 0,1058469 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02616927 0,10567194 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02616927 0,10549757 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02616927 0,10532376 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02616927 0,10515053 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02616927 0,10497787 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02616927 0,10480578 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02616927 0,10463425 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02616927 0,10446328 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02616927 0,10429286 ! response to arsenic GO:0046685 11 5 0,000 0,02616927 0,104123 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02616927 0,1039537 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02616927 0,10378494 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02616927 0,10361673 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02616927 0,10344907 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02616927 0,10328195 ! response to mercury ion GO:0046689 8 5 0,000 0,02616927 0,10311536 ! response to cadmium ion GO:0046686 7 5 0,000 0,02616927 0,10294932 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02616927 0,1027838 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02616927 0,10261882 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02616927 0,10245437 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02616927 0,10229044 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02616927 0,10212704 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02616927 0,10196415 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02616927 0,10180179 ! decidualization GO:0046697 11 5 0,000 0,02616927 0,10163994 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02616927 0,10147861 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02616927 0,10131779 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02616927 0,10115748 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02616927 0,10099767 ! embryonic cleavage GO:0040016 6 5 0,000 0,02616927 0,10083837 ! peroxisome fission GO:0016559 5 5 0,000 0,02616927 0,10067957 ! histone demethylation GO:0016577 13 5 0,000 0,02616927 0,10052127 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02616927 0,10036346 ! mitotic recombination GO:0006312 9 5 0,000 0,02616927 0,10020615 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02616927 0,10004933 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02616927 0,09989301 ! metaphase plate congression GO:0051310 7 5 0,000 0,02616927 0,09973717 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02616927 0,09958181 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02616927 0,09942694 ! enteric nervous system development GO:0048484 8 5 0,000 0,02616927 0,09927255 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02616927 0,09911864 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02616927 0,09896521 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02616927 0,09881225 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02616927 0,09865976 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02616927 0,09850774 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02616927 0,09835619 ! B cell homeostasis GO:0001782 13 5 0,000 0,02616927 0,09820511 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02616927 0,09805449 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02616927 0,09790433 ! metaphase GO:0051323 11 5 0,000 0,02616927 0,09775463 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02616927 0,09760538 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02616927 0,09745659 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02616927 0,09730826 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02616927 0,09716037 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02616927 0,09701294 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02616927 0,09686595 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02616927 0,0967194 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02616927 0,0965733 ! response to redox state GO:0051775 6 5 0,000 0,02616927 0,09642764 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02616927 0,09628242 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02616927 0,09613763 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02616927 0,09599328 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02616927 0,09584936 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02616927 0,09570588 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02616927 0,09556282 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02616927 0,09542019 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02616927 0,09527798 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02616927 0,0951362 ! striatum development GO:0021756 14 5 0,000 0,02616927 0,09499484 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02616927 0,09485389 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02616927 0,09471337 ! glial cell migration GO:0008347 10 5 0,000 0,02616927 0,09457326 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02616927 0,09443357 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02616927 0,09429428 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02616927 0,09415541 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02616927 0,09401695 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02616927 0,09387889 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02616927 0,09374124 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02616927 0,09360399 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02616927 0,09346714 ! neuroprotection GO:0043526 8 5 0,000 0,02616927 0,09333069 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02616927 0,09319464 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02616927 0,09305899 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02616927 0,09292373 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02616927 0,09278886 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02616927 0,09265438 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02616927 0,0925203 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02616927 0,0923866 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02616927 0,09225328 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02616927 0,09212035 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02616927 0,09198781 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02616927 0,09185564 ! spindle assembly GO:0051225 6 5 0,000 0,02616927 0,09172385 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02616927 0,09159244 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02616927 0,09146141 ! protein palmitoylation GO:0018345 12 5 0,000 0,02616927 0,09133075 ! drug metabolic process GO:0017144 7 5 0,000 0,02616927 0,09120046 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02616927 0,09107055 ! organ regeneration GO:0031100 7 5 0,000 0,02616927 0,090941 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02616927 0,09081183 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02616927 0,09068301 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,02676896 0,09262971 ! mitochondrial transport GO:0006839 94 48 1,000 0,02676896 0,09249869 ! cellular component disassembly GO:0022411 89 48 1,000 0,02676896 0,09236804 ! endosome transport GO:0016197 127 48 1,000 0,02676896 0,09223776 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,02676896 0,09210785 ! regulation of adaptive immune response GO:0002819 92 48 1,000 0,02676896 0,0919783 ! methylation GO:0032259 97 48 1,000 0,02676896 0,09184912 ! protein homooligomerization GO:0051260 84 49 1,000 0,0278126 0,09529619 ! regulation of action potential GO:0001508 102 50 1,000 0,0288724 0,09878889 ! induction of apoptosis by extracellular signals GO:0008624 99 50 1,000 0,0288724 0,09865073 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,0288724 0,09851295 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,0288724 0,09837555 ! viral infectious cycle GO:0019058 104 51 1,000 0,02994816 0,10189882 ! response to temperature stimulus GO:0009266 84 51 1,000 0,02994816 0,10175709 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03103968 0,10531937 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,03103968 0,10517329 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,03103968 0,10502763 ! amino acid activation GO:0043038 98 52 1,000 0,03103968 0,10488236 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,0313208 0,10568606 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,0313208 0,10554029 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,0313208 0,10539492 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,0313208 0,10524994 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,0313208 0,10510537 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,0313208 0,10496119 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,0313208 0,10481741 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,0313208 0,10467402 ! response to oxygen radical GO:0000305 11 6 0,000 0,0313208 0,10453102 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,0313208 0,10438842 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,0313208 0,1042462 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,0313208 0,10410437 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,0313208 0,10396292 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,0313208 0,10382186 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,0313208 0,10368118 ! forebrain regionalization GO:0021871 9 6 0,000 0,0313208 0,10354088 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,0313208 0,10340096 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,0313208 0,10326142 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,0313208 0,10312225 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,0313208 0,10298346 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,0313208 0,10284504 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,0313208 0,10270699 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,0313208 0,10256932 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,0313208 0,10243201 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,0313208 0,10229507 ! malate metabolic process GO:0006108 13 6 0,000 0,0313208 0,10215849 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,0313208 0,10202228 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,0313208 0,10188643 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,0313208 0,10175094 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,0313208 0,10161582 ! protein refolding GO:0042026 15 6 0,000 0,0313208 0,10148105 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,0313208 0,10134664 ! opsonization GO:0008228 8 6 0,000 0,0313208 0,10121258 ! mating behavior GO:0007617 7 6 0,000 0,0313208 0,10107888 ! erythrocyte maturation GO:0043249 8 6 0,000 0,0313208 0,10094553 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,0313208 0,10081253 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,0313208 0,10067988 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,0313208 0,10054758 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,0313208 0,10041563 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,0313208 0,10028402 ! response to interferon-gamma GO:0034341 16 6 0,000 0,0313208 0,10015276 ! toxin metabolic process GO:0009404 11 6 0,000 0,0313208 0,10002184 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,0313208 0,09989127 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,0313208 0,09976103 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,0313208 0,09963113 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,0313208 0,09950157 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,0313208 0,09937235 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,0313208 0,09924346 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,0313208 0,09911491 ! thymic T cell selection GO:0045061 16 6 0,000 0,0313208 0,09898669 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,0313208 0,0988588 ! protein lipoylation GO:0009249 10 6 0,000 0,0313208 0,09873124 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,0313208 0,09860401 GO:0070633|transepithelial transport, ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,0313208 0,0984771 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,0313208 0,09835053 ! glutamate catabolic process GO:0006538 12 6 0,000 0,0313208 0,09822427 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,0313208 0,09809835 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,0313208 0,09797274 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,0313208 0,09784745 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,0313208 0,09772249 ! hyperosmotic response GO:0006972 10 6 0,000 0,0313208 0,09759784 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,0313208 0,09747352 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,0313208 0,0973495 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,0313208 0,09722581 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,0313208 0,09710242 ! urea metabolic process GO:0019627 7 6 0,000 0,0313208 0,09697935 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,0313208 0,09685659 ! neutrophil activation GO:0042119 7 6 0,000 0,0313208 0,09673415 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,0313208 0,09661201 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,0313208 0,09649018 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,0313208 0,09636865 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,0313208 0,09624743 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,0313208 0,09612652 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,0313208 0,09600591 ! neuron apoptosis GO:0051402 15 6 0,000 0,0313208 0,0958856 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,0313208 0,09576559 ! T cell mediated immunity GO:0002456 17 6 0,000 0,0313208 0,09564589 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,0313208 0,09552648 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,0313208 0,09540737 ! carnitine transport GO:0015879 10 6 0,000 0,0313208 0,09528855 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0313208 0,09517004 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,0313208 0,09505181 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,0313208 0,09493388 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,0313208 0,09481624 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,0313208 0,0946989 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,0313208 0,09458184 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,0313208 0,09446507 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,0313208 0,09434859 ! establishment of spindle localization GO:0051293 16 6 0,000 0,0313208 0,0942324 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,0313208 0,09411649 ! neural nucleus development GO:0048857 19 6 0,000 0,0313208 0,09400087 ! astrocyte development GO:0014002 16 6 0,000 0,0313208 0,09388553 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,0313208 0,09377048 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,0313208 0,0936557 ! interaction with symbiont GO:0051702 14 6 0,000 0,0313208 0,09354121 ! regulation of dendrite development GO:0050773 16 6 0,000 0,0313208 0,093427 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,0313208 0,09331306 ! response to copper ion GO:0046688 10 6 0,000 0,0313208 0,0931994 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,0313208 0,09308602 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0313208 0,09297292 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,0313208 0,09286008 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,0313208 0,09274753 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,0313208 0,09263524 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,0313208 0,09252323 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,0313208 0,09241149 ! hair follicle maturation GO:0048820 8 6 0,000 0,0313208 0,09230001 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,0313208 0,09218881 ! Schwann cell development GO:0014044 15 6 0,000 0,0313208 0,09207787 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,0313208 0,0919672 ! response to pheromone GO:0019236 6 6 0,000 0,0313208 0,09185679 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,0313208 0,09174665 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,0313208 0,09163678 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,0313208 0,09152716 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,0313208 0,09141781 ! subpallium development GO:0021544 15 6 0,000 0,0313208 0,09130872 ! neural tube patterning GO:0021532 8 6 0,000 0,0313208 0,09119989 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,0313208 0,09109132 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,0313208 0,09098301 ! maintenance of organ identity GO:0048496 9 6 0,000 0,0313208 0,09087495 ! G2 phase GO:0051319 16 6 0,000 0,0313208 0,09076715 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,0313208 0,09065961 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,0313208 0,09055232 ! oxygen homeostasis GO:0032364 10 6 0,000 0,0313208 0,09044528 ! establishment of planar polarity GO:0001736 7 6 0,000 0,0313208 0,0903385 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,0313208 0,09023197 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,0313208 0,09012569 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,0313208 0,09001966 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,0313208 0,08991388 ! receptor internalization GO:0031623 11 6 0,000 0,0313208 0,08980834 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,0313208 0,08970306 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,0313208 0,08959802 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,0313208 0,08949323 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0313208 0,08938868 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,0313208 0,08928438 ! protein deubiquitination GO:0016579 16 6 0,000 0,0313208 0,08918031 ! protein destabilization GO:0031648 9 6 0,000 0,0313208 0,0890765 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,0313208 0,08897292 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,0313208 0,08886958 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,0313208 0,08876648 ! regulation of viral transcription GO:0046782 11 6 0,000 0,0313208 0,08866363 ! progesterone metabolic process GO:0042448 12 6 0,000 0,0313208 0,08856101 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,0313208 0,08845862 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,0313208 0,08835648 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,0313208 0,08825457 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,0313208 0,08815289 ! determination of adult lifespan GO:0008340 17 6 0,000 0,0313208 0,08805145 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,0313208 0,08795024 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,0313208 0,08784926 ! neural plate development GO:0001840 9 6 0,000 0,0313208 0,08774852 ! catecholamine transport GO:0051937 9 6 0,000 0,0313208 0,08764801 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,0313208 0,08754772 ! sensory cilium assembly GO:0035058 10 6 0,000 0,0313208 0,08744767 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,0313208 0,08734784 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,0313208 0,08724824 ! maternal placenta development GO:0001893 12 6 0,000 0,0313208 0,08714887 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,0313208 0,08704973 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,0313208 0,08695081 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,0313208 0,08685211 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,0313208 0,08675364 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,0313208 0,08665539 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,0313208 0,08655736 GO:0055081|anion homeostasis, ! positive regulation of growth GO:0045927 96 53 1,000 0,03214678 0,08873964 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,03214678 0,08863948 ! cartilage development GO:0051216 99 53 1,000 0,03214678 0,08853955 ! synapse organization GO:0050808 102 53 1,000 0,03214678 0,08843984 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,03326925 0,09142494 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,03326925 0,09132222 GO:0010863|positive regulation of phospholipase C activity, ! glutamine family amino acid metabolic process GO:0009064 85 54 1,000 0,03326925 0,09121973 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,03326925 0,09111746 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,03440691 0,09412774 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,03440691 0,09402245 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03440691 0,0939174 ! cell maturation GO:0048469 107 55 1,000 0,03440691 0,09381258 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,03440691 0,09370799 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,03555956 0,09673942 ! tRNA transcription GO:0009304 17 7 0,000 0,03644522 0,09903857 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03644522 0,09892852 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03644522 0,09881873 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03644522 0,09870917 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03644522 0,09859986 ! sleep GO:0030431 16 7 0,000 0,03644522 0,09849079 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03644522 0,09838196 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03644522 0,09827337 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03644522 0,09816502 ! prostate gland development GO:0030850 14 7 0,000 0,03644522 0,09805691 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03644522 0,09794903 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03644522 0,0978414 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03644522 0,097734 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03644522 0,09762683 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03644522 0,0975199 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03644522 0,09741321 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03644522 0,09730674 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03644522 0,09720051 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03644522 0,09709452 ! glycolipid transport GO:0046836 11 7 0,000 0,03644522 0,09698875 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03644522 0,09688321 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03644522 0,0967779 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,03644522 0,09667282 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03644522 0,09656797 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03644522 0,09646335 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03644522 0,09635895 ! pericardium development GO:0060039 16 7 0,000 0,03644522 0,09625478 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03644522 0,09615083 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03644522 0,09604711 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03644522 0,09594361 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03644522 0,09584034 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03644522 0,09573728 ! lipoprotein transport GO:0042953 14 7 0,000 0,03644522 0,09563445 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03644522 0,09553184 ! rhythmic behavior GO:0007622 17 7 0,000 0,03644522 0,09542944 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03644522 0,09532727 GO:0042069|regulation of catecholamine metabolic process, ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03644522 0,09522532 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03644522 0,09512358 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03644522 0,09502206 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03644522 0,09492076 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03644522 0,09481967 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03644522 0,0947188 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03644522 0,09461814 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03644522 0,0945177 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03644522 0,09441747 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03644522 0,09431745 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03644522 0,09421764 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03644522 0,09411805 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03644522 0,09401866 ! spinal cord patterning GO:0021511 14 7 0,000 0,03644522 0,09391948 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03644522 0,09382052 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03644522 0,09372176 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03644522 0,09362321 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03644522 0,09352486 ! adrenal gland development GO:0030325 17 7 0,000 0,03644522 0,09342673 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03644522 0,0933288 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03644522 0,09323107 ! ovulation GO:0030728 10 7 0,000 0,03644522 0,09313355 ! adenohypophysis development GO:0021984 11 7 0,000 0,03644522 0,09303623 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03644522 0,09293911 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03644522 0,0928422 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03644522 0,09274549 ! microtubule nucleation GO:0007020 21 7 0,000 0,03644522 0,09264898 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03644522 0,09255267 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03644522 0,09245656 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03644522 0,09236065 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03644522 0,09226494 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03644522 0,09216943 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03644522 0,09207412 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03644522 0,091979 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03644522 0,09188408 ! galactose metabolic process GO:0006012 13 7 0,000 0,03644522 0,09178935 ! vesicle fusion GO:0006906 20 7 0,000 0,03644522 0,09169482 ! response to dietary excess GO:0002021 8 7 0,000 0,03644522 0,09160048 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03644522 0,09150634 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03644522 0,09141239 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03644522 0,09131864 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03644522 0,09122507 ! organ growth GO:0035265 15 7 0,000 0,03644522 0,0911317 ! nucleoside transport GO:0015858 11 7 0,000 0,03644522 0,09103852 ! nucleoside salvage GO:0043174 11 7 0,000 0,03644522 0,09094553 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03644522 0,09085273 ! male sex determination GO:0030238 15 7 0,000 0,03644522 0,09076011 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03644522 0,09066769 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03644522 0,09057545 ! parturition GO:0007567 16 7 0,000 0,03644522 0,09048341 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03644522 0,09039154 ! rRNA modification GO:0000154 14 7 0,000 0,03644522 0,09029987 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03644522 0,09020838 ! spindle checkpoint GO:0031577 16 7 0,000 0,03644522 0,09011708 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03644522 0,09002596 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03644522 0,08993502 ! monocyte differentiation GO:0030224 16 7 0,000 0,03644522 0,08984427 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03644522 0,0897537 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03644522 0,08966331 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03644522 0,08957311 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03644522 0,08948309 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03644522 0,08939324 ! fibrinolysis GO:0042730 11 7 0,000 0,03644522 0,08930358 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03644522 0,0892141 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03644522 0,0891248 ! eating behavior GO:0042755 8 7 0,000 0,03644522 0,08903567 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03644522 0,08894672 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03644522 0,08885796 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03644522 0,08876936 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03644522 0,08868095 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03644522 0,08859271 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03644522 0,08850464 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03644522 0,08841675 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03644522 0,08832904 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03644522 0,0882415 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03644522 0,08815413 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03644522 0,08806693 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03644522 0,08797991 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03644522 0,08789306 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03644522 0,08780638 ! histone ubiquitination GO:0016574 9 7 0,000 0,03644522 0,08771987 ! regulation of meiosis GO:0040020 12 7 0,000 0,03644522 0,08763353 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03644522 0,08754737 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03644522 0,08746137 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03644522 0,08737554 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03644522 0,08728987 ! transcription termination GO:0006353 14 7 0,000 0,03644522 0,08720438 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03644522 0,08711905 ! anaphase GO:0051322 18 7 0,000 0,03644522 0,08703389 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03644522 0,0869489 ! axonal fasciculation GO:0007413 19 7 0,000 0,03644522 0,08686407 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03644522 0,08677941 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03644522 0,08669491 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03644522 0,08661058 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03644522 0,08652641 ! diuresis GO:0030146 12 7 0,000 0,03644522 0,0864424 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03644522 0,08635856 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03644522 0,08627488 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03644522 0,08619136 ! antibiotic transport GO:0042891 9 7 0,000 0,03644522 0,086108 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03644522 0,0860248 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03644522 0,08594177 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03644522 0,08585889 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03644522 0,08577618 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03644522 0,08569362 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03644522 0,08561122 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03644522 0,08552898 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03644522 0,0854469 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03644522 0,08536498 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03644522 0,08528321 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03644522 0,0852016 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03644522 0,08512014 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03644522 0,08503885 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03644522 0,0849577 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03644522 0,08487671 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03644522 0,08479588 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03644522 0,0847152 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03644522 0,08463467 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03644522 0,08455429 ! muscle adaptation GO:0043500 13 7 0,000 0,03644522 0,08447407 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03644522 0,084394 ! retina homeostasis GO:0001895 12 7 0,000 0,03644522 0,08431408 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03644522 0,08423432 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03644522 0,0841547 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03644522 0,08407523 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03644522 0,08399592 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,03672701 0,08456559 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,03672701 0,08448596 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,03672701 0,08440649 ! regulation of actin filament length GO:0030832 118 58 1,000 0,03790909 0,08704127 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,03790909 0,08695954 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,03790909 0,08687796 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,03790909 0,08679654 ! lipid modification GO:0030258 112 60 1,000 0,04031636 0,09222179 ! DNA catabolic process GO:0006308 94 60 1,000 0,04031636 0,09213552 ! regulation of cellular component size GO:0032535 125 61 1,000 0,04154119 0,09484591 ! camera-type eye development GO:0043010 126 61 1,000 0,04154119 0,09475735 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04154268 0,09467235 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04154268 0,09458412 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04154268 0,09449605 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04154268 0,09440815 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04154268 0,09432041 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04154268 0,09423283 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04154268 0,09414541 ! male meiosis GO:0007140 9 8 0,000 0,04154268 0,09405816 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04154268 0,09397107 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04154268 0,09388414 ! meiotic prophase I GO:0007128 14 8 0,000 0,04154268 0,09379737 ! response to zinc ion GO:0010043 12 8 0,000 0,04154268 0,09371076 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04154268 0,09362431 ! oligopeptide transport GO:0006857 16 8 0,000 0,04154268 0,09353802 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04154268 0,09345189 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04154268 0,09336592 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04154268 0,09328011 ! signal peptide processing GO:0006465 12 8 0,000 0,04154268 0,09319445 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04154268 0,09310895 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04154268 0,09302361 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04154268 0,09293842 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04154268 0,09285339 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04154268 0,09276852 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,04154268 0,0926838 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04154268 0,09259923 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04154268 0,09251482 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04154268 0,09243056 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04154268 0,09234646 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04154268 0,09226251 ! reflex GO:0060004 17 8 0,000 0,04154268 0,09217871 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04154268 0,09209506 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04154268 0,09201157 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04154268 0,09192822 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04154268 0,09184503 ! pigment granule organization GO:0048753 17 8 0,000 0,04154268 0,09176199 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04154268 0,09167909 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04154268 0,09159635 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04154268 0,09151376 ! histidine catabolic process GO:0006548 10 8 0,000 0,04154268 0,09143131 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04154268 0,09134902 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04154268 0,09126687 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04154268 0,09118487 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04154268 0,09110301 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04154268 0,09102131 ! melanin metabolic process GO:0006582 17 8 0,000 0,04154268 0,09093975 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04154268 0,09085833 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04154268 0,09077706 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04154268 0,09069594 ! macrophage activation GO:0042116 13 8 0,000 0,04154268 0,09061496 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04154268 0,09053413 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! purine salvage GO:0043101 12 8 0,000 0,04154268 0,09045344 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04154268 0,09037289 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04154268 0,09029249 ! osteoblast development GO:0002076 17 8 0,000 0,04154268 0,09021223 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04154268 0,09013211 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04154268 0,09005214 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04154268 0,0899723 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04154268 0,08989261 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04154268 0,08981306 ! response to UV-B GO:0010224 17 8 0,000 0,04154268 0,08973365 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04154268 0,08965438 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04154268 0,08957525 ! intermediate filament organization GO:0045109 12 8 0,000 0,04154268 0,08949626 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04154268 0,08941741 ! cellular extravasation GO:0045123 13 8 0,000 0,04154268 0,08933869 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04154268 0,08926012 ! response to antibiotic GO:0046677 11 8 0,000 0,04154268 0,08918168 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04154268 0,08910339 ! response to tropane GO:0014073 15 8 0,000 0,04154268 0,08902523 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04154268 0,0889472 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04154268 0,08886931 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04154268 0,08879156 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04154268 0,08871395 ! gas homeostasis GO:0033483 14 8 0,000 0,04154268 0,08863647 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04154268 0,08855912 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04154268 0,08848192 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04154268 0,08840484 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04154268 0,0883279 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04154268 0,08825109 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04154268 0,08817442 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04154268 0,08809788 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04154268 0,08802147 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04154268 0,0879452 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04154268 0,08786905 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04154268 0,08779304 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04154268 0,08771716 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04154268 0,08764141 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04154268 0,0875658 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04154268 0,08749031 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04154268 0,08741495 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04154268 0,08733972 ! hormone catabolic process GO:0042447 17 8 0,000 0,04154268 0,08726462 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04154268 0,08718965 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04154268 0,08711481 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04154268 0,0870401 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04154268 0,08696552 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04154268 0,08689106 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04154268 0,08681673 ! adult feeding behavior GO:0008343 10 8 0,000 0,04154268 0,08674253 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04154268 0,08666845 ! ATP catabolic process GO:0006200 11 8 0,000 0,04154268 0,0865945 ! blastocyst growth GO:0001832 19 8 0,000 0,04154268 0,08652068 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04154268 0,08644698 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04154268 0,08637341 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04154268 0,08629996 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04154268 0,08622664 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04154268 0,08615344 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04154268 0,08608037 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04154268 0,08600742 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04154268 0,08593459 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04154268 0,08586189 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04154268 0,08578931 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04154268 0,08571686 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04154268 0,08564452 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04154268 0,08557231 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04154268 0,08550022 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04154268 0,08542825 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04154268 0,0853564 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04154268 0,08528467 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04154268 0,08521306 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04154268 0,08514157 ! viral reproductive process GO:0022415 132 62 1,000 0,0427799 0,08760377 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,0427799 0,0875304 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,0427799 0,08745715 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,04403232 0,08994227 ! mesoderm development GO:0007498 128 63 1,000 0,04403232 0,08986713 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,04403232 0,08979212 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,04529827 0,09229664 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 0,04529827 0,09221973 ! axon extension GO:0048675 16 9 0,000 0,04661331 0,09481791 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,04661331 0,09473903 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04661331 0,09466027 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04661331 0,09458165 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04661331 0,09450316 GO:0006740|NADPH regeneration, ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,04661331 0,0944248 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,04661331 0,09434657 ! reproductive behavior GO:0019098 22 9 0,000 0,04661331 0,09426847 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04661331 0,0941905 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,04661331 0,09411265 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04661331 0,09403494 ! UTP metabolic process GO:0046051 10 9 0,000 0,04661331 0,09395735 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04661331 0,09387989 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04661331 0,09380256 ! artery development GO:0060840 25 9 0,000 0,04661331 0,09372536 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04661331 0,09364828 ! regulation of glycolysis GO:0006110 20 9 0,000 0,04661331 0,09357133 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,04661331 0,09349451 ! equilibrioception GO:0050957 20 9 0,000 0,04661331 0,09341781 ! chemosensory behavior GO:0007635 21 9 0,000 0,04661331 0,09334124 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,04661331 0,09326479 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04661331 0,09318847 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04661331 0,09311227 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04661331 0,0930362 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04661331 0,09296025 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04661331 0,09288443 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04661331 0,09280873 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04661331 0,09273315 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04661331 0,0926577 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04661331 0,09258237 ! protein targeting to ER GO:0045047 25 9 0,000 0,04661331 0,09250716 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04661331 0,09243207 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,04661331 0,0923571 ! T cell selection GO:0045058 27 9 0,000 0,04661331 0,09228226 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04661331 0,09220754 ! glycine catabolic process GO:0006546 15 9 0,000 0,04661331 0,09213294 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04661331 0,09205846 ! endosome organization GO:0007032 20 9 0,000 0,04661331 0,0919841 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04661331 0,09190986 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04661331 0,09183573 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04661331 0,09176173 ! mannose metabolic process GO:0006013 13 9 0,000 0,04661331 0,09168785 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04661331 0,09161409 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04661331 0,09154044 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,04661331 0,09146692 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04661331 0,09139351 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04661331 0,09132022 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04661331 0,09124704 ! retinol metabolic process GO:0042572 20 9 0,000 0,04661331 0,09117399 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04661331 0,09110105 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04661331 0,09102823 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,04661331 0,09095552 ! macrophage differentiation GO:0030225 15 9 0,000 0,04661331 0,09088293 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04661331 0,09081045 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04661331 0,0907381 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04661331 0,09066585 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04661331 0,09059372 ! response to amine stimulus GO:0014075 13 9 0,000 0,04661331 0,09052171 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04661331 0,09044981 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04661331 0,09037802 ! erythrocyte development GO:0048821 17 9 0,000 0,04661331 0,09030635 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04661331 0,09023479 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,04661331 0,09016335 ! renal water homeostasis GO:0003091 15 9 0,000 0,04661331 0,09009202 ! postreplication repair GO:0006301 25 9 0,000 0,04661331 0,0900208 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04661331 0,08994969 ! icosanoid secretion GO:0032309 15 9 0,000 0,04661331 0,0898787 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04661331 0,08980782 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04661331 0,08973705 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04661331 0,08966639 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04661331 0,08959584 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04661331 0,0895254 ! sterol catabolic process GO:0016127 14 9 0,000 0,04661331 0,08945507 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04661331 0,08938486 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04661331 0,08931475 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04661331 0,08924476 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,04661331 0,08917487 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,04661331 0,08910509 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04661331 0,08903543 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04661331 0,08896587 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04661331 0,08889642 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04661331 0,08882708 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04661331 0,08875784 ! purine base metabolic process GO:0006144 25 9 0,000 0,04661331 0,08868872 ! pigment granule transport GO:0051904 17 9 0,000 0,04661331 0,0886197 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,04661331 0,08855079 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04661331 0,08848198 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04661331 0,08841328 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04661331 0,08834469 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,04661331 0,08827621 ! mitochondrion localization GO:0051646 18 9 0,000 0,04661331 0,08820783 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,04787005 0,09051589 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,04917553 0,09291247 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,04917553 0,09284067 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,04917553 0,09276898 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,05049385 0,09518246 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,05049385 0,09510907 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,05049385 0,0950358 ! viral reproduction GO:0016032 142 68 1,000 0,05049385 0,09496264 ! regulation of lipase activity GO:0060191 137 68 1,000 0,05049385 0,09488959 ! adaptive immune response GO:0002250 126 68 1,000 0,05049385 0,09481666 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,05165726 0,09692679 ! regulation of developmental growth GO:0048638 16 10 0,000 0,05165726 0,0968524 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05165726 0,09677813 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05165726 0,09670397 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05165726 0,09662992 ! associative learning GO:0008306 21 10 0,000 0,05165726 0,09655599 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05165726 0,09648217 ! phosphate transport GO:0006817 24 10 0,000 0,05165726 0,09640846 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05165726 0,09633487 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05165726 0,09626139 ! CTP metabolic process GO:0046036 11 10 0,000 0,05165726 0,09618802 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,05165726 0,09611476 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,05165726 0,09604161 ! GTP metabolic process GO:0046039 11 10 0,000 0,05165726 0,09596857 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05165726 0,09589565 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05165726 0,09582284 ! social behavior GO:0035176 29 10 0,000 0,05165726 0,09575013 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05165726 0,09567754 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05165726 0,09560506 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05165726 0,09553268 ! androgen metabolic process GO:0008209 17 10 0,000 0,05165726 0,09546042 ! phospholipid efflux GO:0033700 19 10 0,000 0,05165726 0,09538827 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05165726 0,09531622 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05165726 0,09524428 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,05165726 0,09517246 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,05165726 0,09510074 ! pathogenesis GO:0009405 17 10 0,000 0,05165726 0,09502912 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05165726 0,09495762 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05165726 0,09488622 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,05165726 0,09481493 ! endoderm development GO:0007492 18 10 0,000 0,05165726 0,09474375 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05165726 0,09467268 ! arginine catabolic process GO:0006527 17 10 0,000 0,05165726 0,09460171 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05165726 0,09453084 ! proline metabolic process GO:0006560 13 10 0,000 0,05165726 0,09446009 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05165726 0,09438944 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05165726 0,09431889 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05165726 0,09424845 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,05165726 0,09417812 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05165726 0,09410789 ! B cell proliferation GO:0042100 19 10 0,000 0,05165726 0,09403776 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05165726 0,09396774 ! multicellular organism growth GO:0035264 19 10 0,000 0,05165726 0,09389782 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05165726 0,09382801 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05165726 0,0937583 ! ruffle organization GO:0031529 17 10 0,000 0,05165726 0,0936887 ! epithelial cell development GO:0002064 21 10 0,000 0,05165726 0,0936192 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05165726 0,0935498 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05165726 0,0934805 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05165726 0,09341131 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05165726 0,09334222 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05165726 0,09327323 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05165726 0,09320434 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,05165726 0,09313555 ! protein heterooligomerization GO:0051291 17 10 0,000 0,05165726 0,09306687 ! brain morphogenesis GO:0048854 23 10 0,000 0,05165726 0,09299829 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,05165726 0,09292981 ! segment specification GO:0007379 15 10 0,000 0,05165726 0,09286142 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05165726 0,09279314 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,05165726 0,09272496 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05165726 0,09265688 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05165726 0,0925889 ! response to dsRNA GO:0043331 23 10 0,000 0,05165726 0,09252102 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05165726 0,09245324 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05165726 0,09238556 ! melanosome localization GO:0032400 16 10 0,000 0,05165726 0,09231798 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05165726 0,09225049 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05165726 0,09218311 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05165726 0,09211582 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05165726 0,09204863 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05165726 0,09198154 ! induction of an organ GO:0001759 17 10 0,000 0,05165726 0,09191455 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05165726 0,09184765 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05165726 0,09178086 ! protein sumoylation GO:0016925 17 10 0,000 0,05165726 0,09171415 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05165726 0,09164755 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05165726 0,09158104 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05165726 0,09151463 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05165726 0,09144832 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05165726 0,0913821 ! salivary gland development GO:0007431 28 10 0,000 0,05165726 0,09131597 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05165726 0,09124995 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05165726 0,09118401 ! midbrain development GO:0030901 14 10 0,000 0,05165726 0,09111818 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05165726 0,09105244 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05165726 0,09098679 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05165726 0,09092124 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05165726 0,09085578 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05165726 0,09079041 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05165726 0,09072514 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05165726 0,09065997 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05165726 0,09059489 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,05165726 0,0905299 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,05165726 0,090465 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05165726 0,0904002 ! blastocyst formation GO:0001825 18 10 0,000 0,05165726 0,09033549 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05165726 0,09027087 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05165726 0,09020634 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05165726 0,09014191 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05165726 0,09007757 ! response to nicotine GO:0035094 20 10 0,000 0,05165726 0,09001332 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05165726 0,08994916 ! lung development GO:0030324 165 69 1,000 0,05182482 0,09017667 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,05182482 0,09011249 ! developmental maturation GO:0021700 128 69 1,000 0,05182482 0,0900484 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,05452408 0,09467117 ! appendage morphogenesis GO:0035107 150 72 1,000 0,05589203 0,09697744 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 1,000 0,05589203 0,09690862 ! respiratory burst GO:0045730 17 11 0,000 0,05667466 0,09819588 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05667466 0,09812629 ! neuron fate specification GO:0048665 18 11 0,000 0,05667466 0,09805679 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05667466 0,0979874 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05667466 0,0979181 ! thyroid gland development GO:0030878 26 11 0,000 0,05667466 0,0978489 ! synapsis GO:0007129 14 11 0,000 0,05667466 0,0977798 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05667466 0,09771079 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05667466 0,09764189 ! response to pain GO:0048265 27 11 0,000 0,05667466 0,09757308 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,05667466 0,09750436 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05667466 0,09743575 ! bone resorption GO:0045453 16 11 0,000 0,05667466 0,09736722 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05667466 0,0972988 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,05667466 0,09723047 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05667466 0,09716224 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05667466 0,09709411 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05667466 0,09702606 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05667466 0,09695812 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05667466 0,09689027 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05667466 0,09682251 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05667466 0,09675485 ! UV protection GO:0009650 20 11 0,000 0,05667466 0,09668729 ! adult heart development GO:0007512 16 11 0,000 0,05667466 0,09661981 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,05667466 0,09655244 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05667466 0,09648515 ! macroautophagy GO:0016236 19 11 0,000 0,05667466 0,09641796 ! temperature homeostasis GO:0001659 18 11 0,000 0,05667466 0,09635087 ! behavioral fear response GO:0001662 27 11 0,000 0,05667466 0,09628386 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05667466 0,09621695 ! negative regulation of ossification GO:0030279 27 11 0,000 0,05667466 0,09615013 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,05667466 0,09608341 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05667466 0,09601678 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,05667466 0,09595024 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05667466 0,09588379 ! regulation of organ growth GO:0046620 14 11 0,000 0,05667466 0,09581744 ! pigment granule localization GO:0051875 20 11 0,000 0,05667466 0,09575117 ! vasoconstriction GO:0042310 20 11 0,000 0,05667466 0,095685 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05667466 0,09561892 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05667466 0,09555293 ! embryonic axis specification GO:0000578 19 11 0,000 0,05667466 0,09548703 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05667466 0,09542122 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05667466 0,09535551 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05667466 0,09528988 ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05667466 0,09522434 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05667466 0,0951589 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05667466 0,09509354 ! prophase GO:0051324 17 11 0,000 0,05667466 0,09502827 ! nucleosome positioning GO:0016584 15 11 0,000 0,05667466 0,0949631 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05667466 0,09489801 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05667466 0,09483301 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05667466 0,0947681 ! apical protein localization GO:0045176 18 11 0,000 0,05667466 0,09470328 ! acid secretion GO:0046717 20 11 0,000 0,05667466 0,09463855 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05667466 0,0945739 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05667466 0,09450935 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05667466 0,09444488 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05667466 0,0943805 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05667466 0,09431621 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,05667466 0,094252 ! cholesterol efflux GO:0033344 21 11 0,000 0,05667466 0,09418789 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05667466 0,09412386 ! oocyte development GO:0048599 20 11 0,000 0,05667466 0,09405991 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,05667466 0,09399606 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,05667466 0,09393229 ! embryonic gut development GO:0048566 19 11 0,000 0,05667466 0,09386861 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05667466 0,09380501 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05667466 0,0937415 ! activation of innate immune response GO:0002218 16 11 0,000 0,05667466 0,09367807 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05667466 0,09361474 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05667466 0,09355148 ! prepulse inhibition GO:0060134 18 11 0,000 0,05667466 0,09348831 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,05667466 0,09342523 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05667466 0,09336223 ! regulation of embryonic development GO:0045995 35 11 0,000 0,05667466 0,09329932 ! nucleus localization GO:0051647 22 11 0,000 0,05667466 0,09323649 ! appendage development GO:0048736 151 73 1,000 0,05727198 0,09415575 GO:0060173|limb development, ! regulation of immune effector process GO:0002697 156 73 1,000 0,05727198 0,09409243 ! respiratory system development GO:0060541 175 74 1,000 0,05866375 0,09631421 ! eye development GO:0001654 155 75 1,000 0,06006719 0,09855215 ! axon guidance GO:0007411 162 75 1,000 0,06006719 0,098486 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,06148214 0,10073834 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,06148214 0,10067082 ! learning or memory GO:0007611 161 76 1,000 0,06148214 0,10060339 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06166566 0,10083615 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,06166566 0,1007687 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06166566 0,10070134 ! virus-host interaction GO:0019048 30 12 0,000 0,06166566 0,10063407 ! mating GO:0007618 17 12 0,000 0,06166566 0,10056689 ! protein complex disassembly GO:0043241 28 12 0,000 0,06166566 0,1004998 GO:0043624|cellular protein complex disassembly, ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06166566 0,1004328 ! T cell proliferation GO:0042098 32 12 0,000 0,06166566 0,10036589 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06166566 0,10029907 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06166566 0,10023234 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06166566 0,10016569 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06166566 0,10009914 ! drug transport GO:0015893 16 12 0,000 0,06166566 0,10003267 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06166566 0,09996629 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06166566 0,0999 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06166566 0,0998338 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06166566 0,09976768 ! focal adhesion formation GO:0048041 37 12 0,000 0,06166566 0,09970166 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06166566 0,09963572 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06166566 0,09956986 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06166566 0,0995041 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06166566 0,09943842 ! lipid digestion GO:0044241 21 12 0,000 0,06166566 0,09937283 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06166566 0,09930732 ! entry into host cell GO:0030260 34 12 0,000 0,06166566 0,0992419 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06166566 0,09917657 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06166566 0,09911132 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06166566 0,09904616 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06166566 0,09898108 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06166566 0,09891609 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06166566 0,09885118 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06166566 0,09878636 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06166566 0,09872163 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06166566 0,09865698 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06166566 0,09859241 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06166566 0,09852793 ! cranial nerve development GO:0021545 23 12 0,000 0,06166566 0,09846353 ! fucose catabolic process GO:0019317 25 12 0,000 0,06166566 0,09839922 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06166566 0,09833499 ! histone acetylation GO:0016573 27 12 0,000 0,06166566 0,09827084 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06166566 0,09820678 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06166566 0,0981428 ! zymogen activation GO:0031638 18 12 0,000 0,06166566 0,09807891 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,06166566 0,0980151 ! T cell homeostasis GO:0043029 28 12 0,000 0,06166566 0,09795137 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06166566 0,09788772 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06166566 0,09782416 ! oocyte differentiation GO:0009994 21 12 0,000 0,06166566 0,09776068 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06166566 0,09769728 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06166566 0,09763396 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06166566 0,09757073 ! defense response to fungus GO:0050832 15 12 0,000 0,06166566 0,09750758 ! developmental induction GO:0031128 22 12 0,000 0,06166566 0,0974445 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,06166566 0,09738152 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06166566 0,09731861 ! response to cold GO:0009409 17 12 0,000 0,06166566 0,09725578 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06166566 0,09719303 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06166566 0,09713037 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,06290843 0,09902403 ! blood coagulation GO:0007596 151 79 1,000 0,06579442 0,10350018 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,06579442 0,10343358 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,06579442 0,10336706 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,06579442 0,10330063 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,06663039 0,10454595 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06663039 0,10447885 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,06663039 0,10441183 ! regulation of chemokine production GO:0032642 18 13 0,000 0,06663039 0,1043449 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,06663039 0,10427806 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,06663039 0,1042113 ! peroxisomal transport GO:0043574 28 13 0,000 0,06663039 0,10414462 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,06663039 0,10407803 ! organelle fusion GO:0048284 36 13 0,000 0,06663039 0,10401153 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,06663039 0,10394511 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,06663039 0,10387878 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,06663039 0,10381253 ! endocrine pancreas development GO:0031018 25 13 0,000 0,06663039 0,10374636 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,06663039 0,10368028 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,06663039 0,10361429 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,06663039 0,10354837 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,06663039 0,10348255 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,06663039 0,1034168 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,06663039 0,10335114 ! methionine metabolic process GO:0006555 31 13 0,000 0,06663039 0,10328556 ! plasma membrane organization GO:0007009 27 13 0,000 0,06663039 0,10322007 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,06663039 0,10315465 ! Golgi organization GO:0007030 25 13 0,000 0,06663039 0,10308933 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,06663039 0,10302408 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,06663039 0,10295891 ! exocrine system development GO:0035272 34 13 0,000 0,06663039 0,10289383 ! asymmetric protein localization GO:0008105 24 13 0,000 0,06663039 0,10282883 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,06663039 0,10276392 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,06663039 0,10269908 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,06663039 0,10263433 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,06663039 0,10256966 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,06663039 0,10250507 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,06663039 0,10244056 ! protein homotetramerization GO:0051289 24 13 0,000 0,06663039 0,10237613 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,06663039 0,10231178 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,06663039 0,10224752 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,06663039 0,10218333 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,06663039 0,10211922 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06663039 0,1020552 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,06663039 0,10199126 ! histone methylation GO:0016571 29 13 0,000 0,06663039 0,10192739 ! chromatin silencing GO:0006342 29 13 0,000 0,06663039 0,10186361 ! gland morphogenesis GO:0022612 31 13 0,000 0,06663039 0,1017999 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,06663039 0,10173628 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,06663039 0,10167273 ! regulation of epidermis development GO:0045682 19 13 0,000 0,06663039 0,10160927 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,06663039 0,10154588 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,06663039 0,10148257 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,06663039 0,10141934 ! spleen development GO:0048536 24 13 0,000 0,06663039 0,10135619 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,06663039 0,10129312 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,06663039 0,10123013 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,06663039 0,10116721 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,06663039 0,10110438 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,06663039 0,10104162 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,06663039 0,10097894 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,06663039 0,10091633 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,06663039 0,10085381 ! insulin secretion GO:0030073 24 13 0,000 0,06663039 0,10079136 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,06663039 0,10072899 ! acrosome reaction GO:0007340 19 13 0,000 0,06663039 0,10066669 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,06663039 0,10060448 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,06663039 0,10054234 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,06725381 0,10142041 ! response to hypoxia GO:0001666 178 81 1,000 0,06872393 0,10357344 ! protein import into nucleus GO:0006606 174 82 1,000 0,07020461 0,10573974 ! rRNA transcription GO:0009303 28 14 0,000 0,07156899 0,10772831 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07156899 0,10766198 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07156899 0,10759572 ! water transport GO:0006833 21 14 0,000 0,07156899 0,10752955 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07156899 0,10746346 ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07156899 0,10739745 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07156899 0,10733152 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,07156899 0,10726568 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07156899 0,10719991 ! lipid localization GO:0010876 32 14 0,000 0,07156899 0,10713422 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,07156899 0,10706862 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,07156899 0,10700309 ! regulated secretory pathway GO:0045055 24 14 0,000 0,07156899 0,10693765 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07156899 0,10687228 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07156899 0,10680699 ! arginine metabolic process GO:0006525 21 14 0,000 0,07156899 0,10674179 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07156899 0,10667666 ! regulation of heart rate GO:0002027 25 14 0,000 0,07156899 0,10661162 ! fear response GO:0042596 34 14 0,000 0,07156899 0,10654665 ! organic alcohol transport GO:0015850 29 14 0,000 0,07156899 0,10648176 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07156899 0,10641695 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,07156899 0,10635222 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,07156899 0,10628757 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07156899 0,106223 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07156899 0,1061585 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07156899 0,10609408 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,07156899 0,10602975 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07156899 0,10596549 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07156899 0,1059013 ! ribosome assembly GO:0042255 18 14 0,000 0,07156899 0,1058372 ! cerebellum development GO:0021549 23 14 0,000 0,07156899 0,10577317 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07156899 0,10570922 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07156899 0,10564535 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07156899 0,10558155 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07156899 0,10551783 ! NADP metabolic process GO:0006739 24 14 0,000 0,07156899 0,10545419 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07156899 0,10539063 ! oxygen transport GO:0015671 22 14 0,000 0,07156899 0,10532714 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07156899 0,10526373 ! male genitalia development GO:0030539 26 14 0,000 0,07156899 0,10520039 ! regulation of axon extension GO:0030516 43 14 0,000 0,07156899 0,10513713 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07156899 0,10507395 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,07169571 0,10519677 ! response to oxygen levels GO:0070482 183 83 1,000 0,07169571 0,10513362 ! nuclear import GO:0051170 177 83 1,000 0,07169571 0,10507055 ! response to metal ion GO:0010038 158 84 1,000 0,07319708 0,10720651 ! T cell activation GO:0042110 189 84 1,000 0,07319708 0,10714227 ! regulation of ligase activity GO:0051340 147 84 1,000 0,07319708 0,10707812 ! hemostasis GO:0007599 165 85 1,000 0,07470856 0,10922383 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,07470856 0,1091585 ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,07470856 0,10909325 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,07623002 0,11124847 ! regulation of lyase activity GO:0051339 169 86 1,000 0,07623002 0,11118205 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,0764816 0,11148243 ! lactation GO:0007595 30 15 0,000 0,0764816 0,11141595 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,0764816 0,11134956 ! reproductive cellular process GO:0048610 22 15 0,000 0,0764816 0,11128324 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,0764816 0,111217 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,0764816 0,11115084 ! superoxide anion generation GO:0042554 22 15 0,000 0,0764816 0,11108475 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,0764816 0,11101875 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,0764816 0,11095282 ! copper ion transport GO:0006825 22 15 0,000 0,0764816 0,11088698 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,0764816 0,11082121 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,0764816 0,11075552 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,0764816 0,1106899 ! sulfate transport GO:0008272 27 15 0,000 0,0764816 0,11062437 ! response to cAMP GO:0051591 25 15 0,000 0,0764816 0,11055891 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,0764816 0,11049353 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,0764816 0,11042822 ! response to hexose stimulus GO:0009746 25 15 0,000 0,0764816 0,110363 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,0764816 0,11029785 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,0764816 0,11023278 ! vesicle coating GO:0006901 38 15 0,000 0,0764816 0,11016778 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,0764816 0,11010286 ! regulation of exocytosis GO:0017157 26 15 0,000 0,0764816 0,11003802 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,0764816 0,10997325 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,0764816 0,10990856 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,0764816 0,10984395 ! regulation of vasodilation GO:0042312 27 15 0,000 0,0764816 0,10977941 ! histone deacetylation GO:0016575 24 15 0,000 0,0764816 0,10971495 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,0764816 0,10965056 ! water homeostasis GO:0030104 28 15 0,000 0,0764816 0,10958625 ! cofactor transport GO:0051181 30 15 0,000 0,0764816 0,10952201 ! muscle maintenance GO:0046716 26 15 0,000 0,0764816 0,10945785 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,0764816 0,10939377 ! intestinal absorption GO:0050892 31 15 0,000 0,0764816 0,10932976 ! dopamine metabolic process GO:0042417 35 15 0,000 0,0764816 0,10926582 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,0764816 0,10920196 ! heme biosynthetic process GO:0006783 33 15 0,000 0,0764816 0,10913818 ! cell killing GO:0001906 32 15 0,000 0,0764816 0,10907446 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,0764816 0,10901083 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,0764816 0,10894726 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,0764816 0,10888377 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,0764816 0,10882036 ! actin filament polymerization GO:0030041 27 15 0,000 0,0764816 0,10875702 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,0764816 0,10869375 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,07930226 0,11263687 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,08085276 0,11477239 ! tube morphogenesis GO:0035239 194 89 1,000 0,08085276 0,11470574 ! protein localization in nucleus GO:0034504 192 89 1,000 0,08085276 0,11463917 ! regulation of neurological system process GO:0031644 175 89 1,000 0,08085276 0,11457267 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,08136836 0,11523646 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,08136836 0,1151697 ! positive regulation of cell size GO:0045793 29 16 0,000 0,08136836 0,11510301 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,08136836 0,1150364 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,08136836 0,11496986 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,08136836 0,11490341 ! bone remodeling GO:0046849 28 16 0,000 0,08136836 0,11483703 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,08136836 0,11477072 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08136836 0,1147045 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,08136836 0,11463835 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,08136836 0,11457227 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,08136836 0,11450628 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,08136836 0,11444035 ! startle response GO:0001964 28 16 0,000 0,08136836 0,11437451 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,08136836 0,11430874 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,08136836 0,11424304 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,08136836 0,11417742 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,08136836 0,11411188 ! protein polyubiquitination GO:0000209 41 16 0,000 0,08136836 0,11404641 ! glutamate metabolic process GO:0006536 25 16 0,000 0,08136836 0,11398102 ! pituitary gland development GO:0021983 30 16 0,000 0,08136836 0,1139157 ! response to osmotic stress GO:0006970 27 16 0,000 0,08136836 0,11385046 ! lysosomal transport GO:0007041 31 16 0,000 0,08136836 0,11378529 ! L-amino acid transport GO:0015807 33 16 0,000 0,08136836 0,11372019 ! stem cell development GO:0048864 46 16 0,000 0,08136836 0,11365517 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08136836 0,11359023 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08136836 0,11352535 ! intermediate filament-based process GO:0045103 36 16 0,000 0,08136836 0,11346056 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,08136836 0,11339583 ! negative regulation of immune response GO:0050777 38 16 0,000 0,08136836 0,11333118 ! axon cargo transport GO:0008088 46 16 0,000 0,08136836 0,11326661 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,08136836 0,1132021 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,08136836 0,11313767 ! DNA replication initiation GO:0006270 28 16 0,000 0,08136836 0,11307332 ! neuron recognition GO:0008038 40 16 0,000 0,08136836 0,11300904 ! mRNA splice site selection GO:0006376 44 16 0,000 0,08136836 0,11294483 ! tissue regeneration GO:0042246 27 16 0,000 0,08136836 0,11288069 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,08136836 0,11281663 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,08136836 0,11275263 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,08136836 0,11268872 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,08136836 0,11262487 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,08136836 0,1125611 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08136836 0,11249739 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,08136836 0,11243376 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,08136836 0,11237021 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,08136836 0,11230672 ! peptide hormone processing GO:0016486 27 16 0,000 0,08136836 0,11224331 ! response to inorganic substance GO:0010035 173 90 1,000 0,08241265 0,11361969 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,08398179 0,11571771 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! gland development GO:0048732 220 91 1,000 0,08398179 0,11565248 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,08622939 0,11868079 ! metencephalon development GO:0022037 32 17 0,000 0,08622939 0,11861396 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,08622939 0,11854721 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,08622939 0,11848054 ! filopodium assembly GO:0046847 42 17 0,000 0,08622939 0,11841394 ! endothelial cell migration GO:0043542 31 17 0,000 0,08622939 0,11834741 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08622939 0,11828096 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08622939 0,11821459 ! glial cell development GO:0021782 28 17 0,000 0,08622939 0,11814829 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,08622939 0,11808206 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,08622939 0,11801591 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08622939 0,11794983 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,08622939 0,11788383 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08622939 0,11781789 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,08622939 0,11775204 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08622939 0,11768625 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08622939 0,11762055 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08622939 0,11755491 ! NAD metabolic process GO:0019674 33 17 0,000 0,08622939 0,11748935 ! membrane budding GO:0006900 42 17 0,000 0,08622939 0,11742386 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08622939 0,11735844 ! regulation of protein binding GO:0043393 33 17 0,000 0,08622939 0,11729309 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08622939 0,11722782 ! genitalia development GO:0048806 32 17 0,000 0,08622939 0,11716262 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08622939 0,1170975 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,08622939 0,11703244 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08622939 0,11696746 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,08622939 0,11690255 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,08622939 0,11683771 ! steroid catabolic process GO:0006706 34 17 0,000 0,08622939 0,11677295 ! gas transport GO:0015669 26 17 0,000 0,08622939 0,11670825 ! organic cation transport GO:0015695 32 17 0,000 0,08622939 0,11664363 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08622939 0,11657908 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,08622939 0,1165146 ! regulation of membrane potential GO:0042391 179 94 1,000 0,08874332 0,11984518 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,09034807 0,12194494 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,09034807 0,12187761 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,09106483 0,12277671 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,09106483 0,12270898 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09106483 0,12264134 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,09106483 0,12257377 ! adult walking behavior GO:0007628 36 18 0,000 0,09106483 0,12250627 ! patterning of blood vessels GO:0001569 43 18 0,000 0,09106483 0,12243885 ! heart looping GO:0001947 34 18 0,000 0,09106483 0,1223715 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,09106483 0,12230423 ! centrosome cycle GO:0007098 26 18 0,000 0,09106483 0,12223703 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,09106483 0,1221699 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,09106483 0,12210285 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,09106483 0,12203587 ! glycine metabolic process GO:0006544 30 18 0,000 0,09106483 0,12196896 ! response to retinoic acid GO:0032526 31 18 0,000 0,09106483 0,12190213 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,09106483 0,12183537 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,09106483 0,12176869 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,09106483 0,12170207 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,09106483 0,12163553 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,09106483 0,12156907 ! neural crest cell migration GO:0001755 41 18 0,000 0,09106483 0,12150267 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,09106483 0,12143635 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,09106483 0,1213701 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,09106483 0,12130392 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,09106483 0,12123781 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,09106483 0,12117178 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,09106483 0,12110582 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,09106483 0,12103993 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,09106483 0,12097411 ! detection of bacterium GO:0016045 22 18 0,000 0,09106483 0,12090836 ! nerve development GO:0021675 34 18 0,000 0,09106483 0,12084269 ! defense response to virus GO:0051607 43 18 0,000 0,09106483 0,12077708 ! microspike assembly GO:0030035 46 18 0,000 0,09106483 0,12071155 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,09106483 0,12064609 ! forebrain development GO:0030900 210 98 1,000 0,09521318 0,1260736 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,09521318 0,12600531 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,09587483 0,12681224 ! positive regulation of translation GO:0045727 31 19 0,000 0,09587483 0,12674362 ! negative regulation of defense response GO:0031348 27 19 0,000 0,09587483 0,12667507 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,09587483 0,1266066 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,09587483 0,1265382 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,09587483 0,12646987 ! inositol metabolic process GO:0006020 33 19 0,000 0,09587483 0,12640162 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,09587483 0,12633344 ! memory GO:0007613 34 19 0,000 0,09587483 0,12626534 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,09587483 0,12619731 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,09587483 0,12612935 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,09587483 0,12606147 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,09587483 0,12599365 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,09587483 0,12592592 ! cerebral cortex development GO:0021987 40 19 0,000 0,09587483 0,12585825 ! pigmentation during development GO:0048066 42 19 0,000 0,09587483 0,12579066 ! response to vitamin A GO:0033189 32 19 0,000 0,09587483 0,12572314 ! heme metabolic process GO:0042168 40 19 0,000 0,09587483 0,12565569 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,09587483 0,12558831 ! response to fungus GO:0009620 26 19 0,000 0,09587483 0,12552101 ! peptide cross-linking GO:0018149 39 19 0,000 0,09587483 0,12545378 ! protein export from nucleus GO:0006611 40 19 0,000 0,09587483 0,12538662 ! heart process GO:0003015 32 19 0,000 0,09587483 0,12531953 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,09587483 0,12525251 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,09587483 0,12518557 ! visual learning GO:0008542 38 19 0,000 0,09587483 0,1251187 ! cellular pigmentation GO:0033059 37 19 0,000 0,09587483 0,1250519 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,09587483 0,12498517 ! vitamin transport GO:0051180 31 19 0,000 0,09587483 0,12491851 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,09587483 0,12485192 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,09587483 0,1247854 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,09587483 0,12471896 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,09587483 0,12465258 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,09587483 0,12458628 ! cilium assembly GO:0042384 38 19 0,000 0,09587483 0,12452004 ! peptide hormone secretion GO:0030072 32 19 0,000 0,09587483 0,12445388 ! positive regulation of immune response GO:0050778 175 100 1,000 0,09849762 0,12779059 ! protein secretion GO:0009306 45 20 0,000 0,1006595 0,13052609 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,1006595 0,13045685 ! positive regulation of ossification GO:0045778 50 20 0,000 0,1006595 0,13038768 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,1006595 0,13031858 ! skin development GO:0043588 42 20 0,000 0,1006595 0,13024956 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,1006595 0,1301806 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,1006595 0,13011173 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,1006595 0,13004292 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,1006595 0,12997419 ! response to vitamin GO:0033273 36 20 0,000 0,1006595 0,12990553 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,1006595 0,12983694 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,1006595 0,12976842 GO:0010675|regulation of cellular carbohydrate metabolic process, ! bile acid metabolic process GO:0008206 34 20 0,000 0,1006595 0,12969998 ! response to alkaloid GO:0043279 38 20 0,000 0,1006595 0,12963161 ! retinoid metabolic process GO:0001523 34 20 0,000 0,1006595 0,12956331 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,1006595 0,12949508 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,1006595 0,12942693 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,1006595 0,12935884 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,1006595 0,12929083 ! actin filament bundle formation GO:0051017 47 20 0,000 0,1006595 0,12922289 ! body fluid secretion GO:0007589 33 20 0,000 0,1006595 0,12915502 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,1006595 0,12908722 ! peptide secretion GO:0002790 38 20 0,000 0,1006595 0,1290195 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,1006595 0,12895184 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,1006595 0,12888426 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,1006595 0,12881674 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,1006595 0,1287493 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,1006595 0,12868193 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,1006595 0,12861462 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,1006595 0,12854739 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,1006595 0,12848023 ! regulation of glucose import GO:0046324 30 20 0,000 0,1006595 0,12841314 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,1006595 0,12834612 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,1006595 0,12827917 ! negative regulation of translation GO:0017148 32 20 0,000 0,1006595 0,12821228 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,1006595 0,12814547 ! regulation of cell killing GO:0031341 46 21 0,000 0,10541899 0,13413468 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,10541899 0,13406486 ! hormone secretion GO:0046879 39 21 0,000 0,10541899 0,1339951 ! cAMP metabolic process GO:0046058 41 21 0,000 0,10541899 0,13392542 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,10541899 0,13385581 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,10541899 0,13378628 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,10541899 0,13371682 ! ovarian follicle development GO:0001541 39 21 0,000 0,10541899 0,13364742 ! smooth muscle contraction GO:0006939 48 21 0,000 0,10541899 0,13357811 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,10541899 0,13350886 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,10541899 0,13343968 ! plasma membrane fusion GO:0045026 33 21 0,000 0,10541899 0,13337058 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,10541899 0,13330155 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,10541899 0,13323259 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,10541899 0,1331637 ! sensory perception of pain GO:0019233 33 21 0,000 0,10541899 0,13309488 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,10541899 0,13302613 ! diencephalon development GO:0021536 36 21 0,000 0,10541899 0,13295745 ! collagen fibril organization GO:0030199 62 21 0,000 0,10541899 0,13288885 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,10541899 0,13282031 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,10541899 0,13275185 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,10541899 0,13268346 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,10541899 0,13261513 ! collagen catabolic process GO:0030574 29 21 0,000 0,10541899 0,13254688 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,10541899 0,1324787 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,10541899 0,13241058 ! sperm-egg recognition GO:0035036 23 21 0,000 0,10541899 0,13234254 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,11015342 0,1382151 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,11015342 0,13814415 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,11015342 0,13807327 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,11015342 0,13800246 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,11015342 0,13793173 ! microtubule-based transport GO:0010970 59 22 0,000 0,11015342 0,13786107 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,11015342 0,13779048 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,11015342 0,13771996 ! vacuolar transport GO:0007034 41 22 0,000 0,11015342 0,13764952 ! central nervous system neuron development GO:0021954 47 22 0,000 0,11015342 0,13757914 ! fucose metabolic process GO:0006004 44 22 0,000 0,11015342 0,13750884 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,11015342 0,13743861 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,11015342 0,13736846 ! ureteric bud development GO:0001657 50 22 0,000 0,11015342 0,13729837 ! stem cell differentiation GO:0048863 57 22 0,000 0,11015342 0,13722836 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,11015342 0,13715841 ! cytolysis GO:0019835 27 22 0,000 0,11015342 0,13708854 ! renal system process GO:0003014 42 22 0,000 0,11015342 0,13701874 ! vasodilation GO:0042311 40 22 0,000 0,11015342 0,13694901 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,11015342 0,13687935 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,11015342 0,13680976 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,11015342 0,13674025 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,11015342 0,1366708 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,11015342 0,13660142 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,11015342 0,13653212 ! sarcomere organization GO:0045214 32 22 0,000 0,11015342 0,13646288 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,11015342 0,13639372 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,11015342 0,13632462 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,11015342 0,1362556 ! gut development GO:0048565 44 22 0,000 0,11015342 0,13618664 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,11015342 0,13611776 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,11015342 0,13604894 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,11486293 0,1417939 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11486293 0,14172229 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11486293 0,14165075 ! viral genome replication GO:0019079 44 23 0,000 0,11486293 0,14157928 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,11486293 0,14150788 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11486293 0,14143656 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11486293 0,14136531 ! regeneration GO:0031099 42 23 0,000 0,11486293 0,14129413 ! visual behavior GO:0007632 46 23 0,000 0,11486293 0,14122302 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,11486293 0,14115198 ! response to ethanol GO:0045471 47 23 0,000 0,11486293 0,14108101 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11486293 0,14101012 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11486293 0,14093929 ! peroxisome organization GO:0007031 43 23 0,000 0,11486293 0,14086854 ! lysosome organization GO:0007040 47 23 0,000 0,11486293 0,14079786 ! vesicle targeting GO:0006903 49 23 0,000 0,11486293 0,14072725 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11486293 0,14065671 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,11486293 0,14058624 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11486293 0,14051584 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11486293 0,14044551 ! fatty acid transport GO:0015908 47 23 0,000 0,11486293 0,14037525 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,11486293 0,14030507 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11486293 0,14023495 ! hormone transport GO:0009914 41 23 0,000 0,11486293 0,1401649 ! cell-cell recognition GO:0009988 28 23 0,000 0,11486293 0,14009492 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,11486293 0,14002502 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,11486293 0,13995518 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11486293 0,13988541 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,11954764 0,14551813 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,11954764 0,14544566 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,11954764 0,14537327 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,11954764 0,14530094 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,11954764 0,14522869 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,11954764 0,14515651 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,11954764 0,1450844 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,11954764 0,14501236 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,11954764 0,14494039 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,11954764 0,1448685 GO:0042278|purine nucleoside metabolic process, ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,11954764 0,14479667 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,11954764 0,14472492 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,11954764 0,14465324 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,11954764 0,14458163 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,11954764 0,14451009 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,11954764 0,14443862 ! membrane depolarization GO:0051899 45 24 0,000 0,11954764 0,14436722 ! oogenesis GO:0048477 44 24 0,000 0,11954764 0,1442959 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,11954764 0,14422464 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,11954764 0,14415345 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,11954764 0,14408233 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,11954764 0,14401129 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,11954764 0,14394031 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,11954764 0,14386941 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,11954764 0,14379857 ! regulation of amine transport GO:0051952 41 24 0,000 0,11954764 0,1437278 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,1242077 0,14925696 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,1242077 0,14918358 ! leukocyte adhesion GO:0007159 55 25 0,000 0,1242077 0,14911027 ! phototransduction GO:0007602 37 25 0,000 0,1242077 0,14903703 ! keratinization GO:0031424 37 25 0,000 0,1242077 0,14896387 ! vacuole organization GO:0007033 49 25 0,000 0,1242077 0,14889078 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,1242077 0,14881775 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,1242077 0,1487448 ! interaction with host GO:0051701 66 25 0,000 0,1242077 0,14867193 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,1242077 0,14859912 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,1242077 0,14852638 ! immunoglobulin production GO:0002377 62 25 0,000 0,1242077 0,14845372 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,1242077 0,14838112 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,1242077 0,1483086 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,1242077 0,14823615 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,12884321 0,15369334 ! molting cycle process GO:0022404 52 26 0,000 0,12884321 0,15361834 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,12884321 0,1535434 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,12884321 0,15346854 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,12884321 0,15339375 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,12884321 0,15331903 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,12884321 0,15324439 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,12884321 0,15316981 ! digestive system process GO:0022600 49 26 0,000 0,12884321 0,15309532 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,12884321 0,15302089 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,12884321 0,15294654 ! osteoblast differentiation GO:0001649 63 26 0,000 0,12884321 0,15287225 ! neural crest cell development GO:0014032 59 26 0,000 0,12884321 0,15279804 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,12884321 0,15272391 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,12884321 0,15264984 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,12884321 0,15257585 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,12884321 0,15250192 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,12884321 0,15242807 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,12884321 0,15235429 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,12884321 0,15228059 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,12884321 0,15220695 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,12884321 0,15213338 ! blastocyst development GO:0001824 50 26 0,000 0,12884321 0,15205989 ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,12884321 0,15198647 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,12884321 0,15191311 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,13345432 0,15727396 ! embryonic pattern specification GO:0009880 49 27 0,000 0,13345432 0,15719813 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,13345432 0,15712237 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,13345432 0,15704668 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,13345432 0,15697107 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,13345432 0,15689553 ! iron ion transport GO:0006826 65 27 0,000 0,13345432 0,15682007 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,13345432 0,15674467 ! superoxide metabolic process GO:0006801 41 27 0,000 0,13345432 0,15666935 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,13345432 0,1565941 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,13345432 0,15651892 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,13345432 0,15644382 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,13345432 0,15636878 ! leukocyte proliferation GO:0070661 59 27 0,000 0,13345432 0,15629382 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,13804116 0,16158819 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,13804116 0,1615108 ! protein amino acid acylation GO:0043543 59 28 0,000 0,13804116 0,16143349 ! vesicle docking GO:0048278 55 28 0,000 0,13804116 0,16135624 ! circadian rhythm GO:0007623 56 28 0,000 0,13804116 0,16127908 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,13804116 0,16120198 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,13804116 0,16112496 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,13804116 0,16104802 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,13804116 0,16097115 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,13804116 0,16089435 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,13804116 0,16081762 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,13804116 0,16074097 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,13804116 0,16066439 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,13804116 0,16058788 ! glutathione metabolic process GO:0006749 42 28 0,000 0,13804116 0,16051145 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,13804116 0,16043509 ! lipid oxidation GO:0034440 48 28 0,000 0,13804116 0,1603588 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,13804116 0,16028258 ! translational initiation GO:0006413 66 29 0,000 0,14260384 0,16550175 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,14260384 0,16542317 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,14260384 0,16534465 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,14260384 0,16526622 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,14260384 0,16518786 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,14260384 0,16510957 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,14260384 0,16503135 ! somitogenesis GO:0001756 52 29 0,000 0,14260384 0,16495321 ! synaptogenesis GO:0007416 46 29 0,000 0,14260384 0,16487515 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,14260384 0,16479716 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,14260384 0,16471924 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,14260384 0,16464139 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,1471425 0,1698012 ! phenol metabolic process GO:0018958 56 30 0,000 0,1471425 0,16972103 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,1471425 0,16964093 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,1471425 0,16956091 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,1471425 0,16948097 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,1471425 0,1694011 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,1471425 0,16932131 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,1471425 0,16924159 ! acute-phase response GO:0006953 50 30 0,000 0,1471425 0,16916194 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,1471425 0,16908238 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,1471425 0,16900288 ! myofibril assembly GO:0030239 50 30 0,000 0,1471425 0,16892346 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,1471425 0,16884412 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,1471425 0,16876485 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,1471425 0,16868566 ! cell fate determination GO:0001709 64 30 0,000 0,1471425 0,16860653 ! phospholipid transport GO:0015914 65 30 0,000 0,1471425 0,16852749 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,1471425 0,16844852 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,1471425 0,16836962 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,1471425 0,16829079 ! regulation of coagulation GO:0050818 52 30 0,000 0,1471425 0,16821204 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,15165726 0,17329219 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,15165726 0,17321117 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,15165726 0,17313023 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,15165726 0,17304937 ! regulation of innate immune response GO:0045088 57 31 0,000 0,15165726 0,17296858 ! ovulation cycle process GO:0022602 55 31 0,000 0,15165726 0,17288786 ! peptide transport GO:0015833 60 31 0,000 0,15165726 0,17280723 ! male gonad development GO:0008584 56 31 0,000 0,15165726 0,17272666 ! iron ion homeostasis GO:0055072 60 31 0,000 0,15165726 0,17264617 ! detection of light stimulus GO:0009583 44 31 0,000 0,15165726 0,17256576 ! natural killer cell activation GO:0030101 50 31 0,000 0,15165726 0,17248542 ! cofactor catabolic process GO:0051187 54 31 0,000 0,15165726 0,17240516 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,15165726 0,17232497 ! eye morphogenesis GO:0048592 65 31 0,000 0,15165726 0,17224486 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,15614825 0,17726309 ! collagen metabolic process GO:0032963 49 32 0,000 0,15614825 0,17718076 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,15614825 0,1770985 ! spindle organization GO:0007051 50 32 0,000 0,15614825 0,17701632 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,15614825 0,17693422 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,15614825 0,17685219 ! metanephros development GO:0001656 81 32 0,000 0,15614825 0,17677024 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,15614825 0,17668836 ! muscle cell development GO:0055001 52 32 0,000 0,15614825 0,17660656 ! mesoderm formation GO:0001707 73 32 0,000 0,15614825 0,17652484 ! ovulation cycle GO:0042698 57 32 0,000 0,15614825 0,17644319 ! BMP signaling pathway GO:0030509 71 32 0,000 0,15614825 0,17636162 ! hindbrain development GO:0030902 65 32 0,000 0,15614825 0,17628012 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,15614825 0,17619869 ! gene silencing GO:0016458 71 32 0,000 0,15614825 0,17611735 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,16061559 0,1810724 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,16061559 0,18098888 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,16061559 0,18090543 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,16061559 0,18082207 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,16061559 0,18073878 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,16061559 0,18065556 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,16061559 0,18057243 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,16061559 0,18048937 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,16061559 0,18040638 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,1650594 0,18531255 ! glial cell differentiation GO:0010001 67 34 0,000 0,1650594 0,18522743 ! post-embryonic development GO:0009791 76 34 0,000 0,1650594 0,18514239 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,1650594 0,18505742 ! cholesterol transport GO:0030301 62 34 0,000 0,1650594 0,18497253 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,1650594 0,18488772 ! spliceosome assembly GO:0000245 75 34 0,000 0,1650594 0,18480299 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,1650594 0,18471833 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,1650594 0,18463375 ! formation of primary germ layer GO:0001704 76 34 0,000 0,1650594 0,18454925 ! cell fate specification GO:0001708 56 34 0,000 0,1650594 0,18446483 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,1650594 0,18438048 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,1650594 0,18429622 ! adult locomotory behavior GO:0008344 62 34 0,000 0,1650594 0,18421202 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,1650594 0,18412791 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,16947981 0,1889727 ! negative regulation of secretion GO:0051048 68 35 0,000 0,16947981 0,18888649 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,16947981 0,18880036 ! membrane docking GO:0022406 69 35 0,000 0,16947981 0,18871431 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,16947981 0,18862833 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,16947981 0,18854243 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,16947981 0,18845662 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,16947981 0,18837088 ! ceramide metabolic process GO:0006672 72 35 0,000 0,16947981 0,18828521 ! sterol transport GO:0015918 63 35 0,000 0,16947981 0,18819963 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,16947981 0,18811412 ! vesicle localization GO:0051648 70 35 0,000 0,16947981 0,18802869 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,17387695 0,19281951 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,17387695 0,19273202 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,17387695 0,19264462 ! protein targeting to membrane GO:0006612 75 36 0,000 0,17387695 0,19255729 ! aerobic respiration GO:0009060 56 36 0,000 0,17387695 0,19247004 ! cytokine production GO:0001816 68 36 0,000 0,17387695 0,19238287 ! embryonic organ development GO:0048568 67 36 0,000 0,17387695 0,19229578 ! sister chromatid segregation GO:0000819 65 37 0,000 0,17825092 0,19704389 ! odontogenesis GO:0042476 74 37 0,000 0,17825092 0,19695477 ! actomyosin structure organization GO:0031032 68 37 0,000 0,17825092 0,19686573 ! female gonad development GO:0008585 71 37 0,000 0,17825092 0,19677678 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,17825092 0,1966879 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,18260186 0,2013979 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,18260186 0,20130702 ! meiosis I GO:0007127 74 38 0,000 0,18260186 0,20121622 ! organic anion transport GO:0015711 82 38 0,000 0,18260186 0,2011255 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,18260186 0,20103486 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,18260186 0,2009443 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,18260186 0,20085383 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,18260186 0,20076343 ! spermatid development GO:0007286 69 38 0,000 0,18260186 0,20067312 ! glycogen metabolic process GO:0005977 63 38 0,000 0,18260186 0,20058289 ! pigment metabolic process GO:0042440 87 38 0,000 0,18260186 0,20049274 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,18692989 0,20515261 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,18692989 0,20506049 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,18692989 0,20496845 ! glucan metabolic process GO:0044042 64 39 0,000 0,18692989 0,2048765 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,19123512 0,20950107 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,19123512 0,20940717 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,19123512 0,20931335 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,19123512 0,20921961 ! mismatch repair GO:0006298 58 40 0,000 0,19123512 0,20912596 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,19123512 0,20903239 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,19123512 0,20893891 ! RNA export from nucleus GO:0006405 61 41 0,000 0,19551767 0,21352243 ! mRNA catabolic process GO:0006402 79 41 0,000 0,19551767 0,21342702 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,19551767 0,2133317 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,19551767 0,21323646 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,19551767 0,21314131 ! gliogenesis GO:0042063 91 41 0,000 0,19551767 0,21304624 ! feeding behavior GO:0007631 69 41 0,000 0,19551767 0,21295126 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,19551767 0,21285636 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,19551767 0,21276155 ! RNA modification GO:0009451 64 41 0,000 0,19551767 0,21266682 ! ear morphogenesis GO:0042471 64 42 0,000 0,19977767 0,21720376 ! organic ether metabolic process GO:0018904 59 42 0,000 0,19977767 0,21710714 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,19977767 0,2170106 ! regulation of protein secretion GO:0050708 77 42 0,000 0,19977767 0,21691415 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,20401523 0,22141679 GO:0090047|positive regulation of transcription regulator activity, ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,20401523 0,22131847 ! regulation of tube size GO:0035150 76 43 0,000 0,20401523 0,22122024 GO:0050880|regulation of blood vessel size, ! glucose transport GO:0015758 66 43 0,000 0,20401523 0,22112209 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,20401523 0,22102404 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,20401523 0,22092606 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,20401523 0,22082818 ! segmentation GO:0035282 78 43 0,000 0,20401523 0,22073038 ! ion transmembrane transport GO:0034220 79 43 0,000 0,20401523 0,22063267 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,20823046 0,2250916 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,20823046 0,22499205 ! hexose transport GO:0008645 68 44 0,000 0,20823046 0,22489258 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,20823046 0,22479321 ! striated muscle contraction GO:0006941 85 44 0,000 0,20823046 0,22469392 ! phagocytosis GO:0006909 105 44 0,000 0,20823046 0,22459471 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,20823046 0,2244956 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,2124235 0,22891513 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,2124235 0,2288142 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,2124235 0,22871336 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,2124235 0,2286126 ! female gamete generation GO:0007292 71 45 0,000 0,2124235 0,22851193 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,2124235 0,22841136 ! developmental growth GO:0048589 88 45 0,000 0,2124235 0,22831087 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,21659444 0,23269139 ! glycolysis GO:0006096 71 46 0,000 0,21659444 0,23258911 ! leukocyte migration GO:0050900 75 46 0,000 0,21659444 0,23248692 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,21659444 0,23238481 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,21659444 0,2322828 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,21659444 0,23218088 ! pigmentation GO:0043473 103 46 0,000 0,21659444 0,23207905 ! positive regulation of defense response GO:0031349 88 48 0,000 0,22487053 0,24084117 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,22487053 0,24073563 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,22487053 0,24063018 ! male sex differentiation GO:0046661 93 48 0,000 0,22487053 0,24052483 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,22487053 0,24041957 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,22487053 0,2403144 ! response to calcium ion GO:0051592 94 49 0,000 0,2289759 0,24459472 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,2289759 0,24448782 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,2289759 0,24438101 ! regulation of ion transport GO:0043269 86 50 0,000 0,23305965 0,24863088 ! endocrine system development GO:0035270 109 50 0,000 0,23305965 0,24852236 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,23305965 0,24841393 ! regulation of ossification GO:0030278 123 50 0,000 0,23305965 0,24830559 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,23305965 0,24819735 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,23305965 0,2480892 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,23305965 0,24798115 ! peptide metabolic process GO:0006518 80 51 0,000 0,23712188 0,25219362 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,23712188 0,25208388 ! positive regulation of binding GO:0051099 88 52 0,000 0,24116271 0,25626816 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,24116271 0,25615674 ! Notch signaling pathway GO:0007219 111 52 0,000 0,24116271 0,25604541 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,24116271 0,25593418 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,24116271 0,25582305 ! excretion GO:0007588 87 52 0,000 0,24116271 0,25571202 ! histone modification GO:0016570 104 52 0,000 0,24116271 0,25560108 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,24116271 0,25549024 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,24116271 0,25537949 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,24116271 0,25526884 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,24518224 0,2594111 ! inner ear development GO:0048839 89 53 0,000 0,24518224 0,2592988 ! chromatin remodeling GO:0006338 122 53 0,000 0,24518224 0,2591866 ! vesicle organization GO:0016050 127 53 0,000 0,24518224 0,25907449 ! regulation of translational initiation GO:0006446 87 54 0,000 0,2491806 0,26318557 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,2491806 0,26307183 ! neuromuscular process GO:0050905 107 54 0,000 0,2491806 0,26295819 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,2491806 0,26284465 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,2491806 0,26273121 ! membrane fusion GO:0006944 122 54 0,000 0,2491806 0,26261787 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,2491806 0,26250462 ! covalent chromatin modification GO:0016569 115 54 0,000 0,2491806 0,26239147 ! RNA catabolic process GO:0006401 103 55 0,000 0,25315789 0,26646477 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,25315789 0,26635001 ! cell recognition GO:0008037 98 55 0,000 0,25315789 0,26623536 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,25315789 0,2661208 ! glucose catabolic process GO:0006007 88 56 0,000 0,25711423 0,27016347 ! RNA elongation GO:0006354 90 56 0,000 0,25711423 0,27004732 ! chloride transport GO:0006821 102 57 0,000 0,26104971 0,27406293 ! heart morphogenesis GO:0003007 105 57 0,000 0,26104971 0,27394521 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,26496446 0,27793395 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,26496446 0,27781467 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,26496446 0,27769549 ! gastrulation GO:0007369 122 58 0,000 0,26496446 0,27757641 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,26496446 0,27745743 ! nuclear export GO:0051168 110 59 0,000 0,26885858 0,28141453 ! establishment of organelle localization GO:0051656 122 59 0,000 0,26885858 0,28129401 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,27273218 0,28522462 ! regulation of endocytosis GO:0030100 104 60 0,000 0,27273218 0,28510257 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,27273218 0,28498063 ! adult behavior GO:0030534 104 60 0,000 0,27273218 0,28485879 ! kidney development GO:0001822 133 60 0,000 0,27273218 0,28473705 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,27658536 0,28863649 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,27658536 0,28851325 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,27658536 0,28839011 ! regulation of heart contraction GO:0008016 123 61 0,000 0,27658536 0,28826708 ! proton transport GO:0015992 117 61 0,000 0,27658536 0,28814415 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,27658536 0,28802133 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,28041824 0,29188826 ! tRNA processing GO:0008033 102 62 0,000 0,28041824 0,29176395 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,28423091 0,29560499 ! hydrogen transport GO:0006818 121 64 0,000 0,28802349 0,29942187 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,28802349 0,29929451 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,29179609 0,30308582 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,29179609 0,30295701 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,29179609 0,30282831 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,29179609 0,30269972 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,29179609 0,30257124 ! ear development GO:0043583 114 66 0,000 0,29554879 0,3063325 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,29554879 0,30620259 ! gonad development GO:0008406 115 66 0,000 0,29554879 0,30607279 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,29928172 0,30980731 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,29928172 0,30967609 ! secondary metabolic process GO:0019748 125 67 0,000 0,29928172 0,30954498 ! hexose catabolic process GO:0019320 113 68 0,000 0,30299497 0,31325295 ! extracellular matrix organization GO:0030198 146 68 0,000 0,30299497 0,31312044 ! detection of external stimulus GO:0009581 102 68 0,000 0,30299497 0,31298804 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,30299497 0,31285576 ! cell projection assembly GO:0030031 138 68 0,000 0,30299497 0,31272358 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,30668865 0,31640219 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,30668865 0,31626863 ! urogenital system development GO:0001655 149 69 0,000 0,30668865 0,31613518 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,30668865 0,31600185 ! single fertilization GO:0007338 83 69 0,000 0,30668865 0,31586862 ! cell redox homeostasis GO:0045454 114 70 0,000 0,31036286 0,31951811 ! germ cell development GO:0007281 133 70 0,000 0,31036286 0,31938352 ! activation of immune response GO:0002253 120 70 0,000 0,31036286 0,31924904 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,31036286 0,31911468 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,3140177 0,32273674 ! carbohydrate transport GO:0008643 114 72 0,000 0,31765327 0,32633597 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,31765327 0,3261988 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,31765327 0,32606174 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,31765327 0,3259248 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,31765327 0,32578797 ! humoral immune response GO:0006959 115 73 0,000 0,32126968 0,32935872 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,32126968 0,32922057 ! acute inflammatory response GO:0002526 118 74 0,000 0,32486702 0,33276735 ! amino acid transport GO:0006865 148 74 0,000 0,32486702 0,33262788 ! organelle localization GO:0051640 155 74 0,000 0,32486702 0,33248854 ! transition metal ion transport GO:0000041 143 75 0,000 0,3284454 0,33601009 ! reproductive structure development GO:0048608 131 75 0,000 0,3284454 0,33586945 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,3284454 0,33572891 ! rhythmic process GO:0048511 142 75 0,000 0,3284454 0,3355885 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,33200491 0,33908361 ! regulation of blood pressure GO:0008217 134 76 0,000 0,33200491 0,33894191 ! amine catabolic process GO:0009310 136 77 0,000 0,33554565 0,34241354 ! neurotransmitter transport GO:0006836 142 77 0,000 0,33554565 0,34227057 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,33554565 0,34212772 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,33554565 0,34198499 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,33554565 0,34184238 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,33554565 0,34169989 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,33906773 0,34514269 ! antigen processing and presentation GO:0019882 117 78 0,000 0,33906773 0,34499894 ! fertilization GO:0009566 99 78 0,000 0,33906773 0,34485531 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,34257123 0,34827362 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,34257123 0,34812875 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,34605626 0,35152409 ! meiosis GO:0007126 143 81 0,000 0,34952291 0,35489795 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,34952291 0,35475051 ! meiotic cell cycle GO:0051321 144 82 0,000 0,35297129 0,35810168 ! exocytosis GO:0006887 153 83 0,000 0,35640148 0,36143164 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,35640148 0,36128166 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,35640148 0,36113182 ! inorganic anion transport GO:0015698 156 83 0,000 0,35640148 0,36098209 ! response to nutrient GO:0007584 135 84 0,000 0,35981358 0,36428702 ! digestion GO:0007586 130 84 0,000 0,35981358 0,36413611 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,36320769 0,36741879 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,3699423 0,37407659 ! nucleosome assembly GO:0006334 126 87 0,000 0,3699423 0,37392182 ! cellular respiration GO:0045333 143 88 0,000 0,37328299 0,37714241 ! amine biosynthetic process GO:0009309 146 88 0,000 0,37328299 0,3769865 ! sensory perception of smell GO:0007608 117 88 0,000 0,37328299 0,37683072 ! chromatin assembly GO:0031497 128 88 0,000 0,37328299 0,37667507 ! cellular defense response GO:0006968 123 89 0,000 0,37660606 0,37987143 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,3799116 0,38304748 ! response to unfolded protein GO:0006986 139 90 0,000 0,3799116 0,38288946 ! defense response to bacterium GO:0042742 112 91 0,000 0,38319971 0,38604408 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,38647048 0,38917864 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,38972399 0,39229325 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,38972399 0,39213167 ! vitamin metabolic process GO:0006766 153 93 0,000 0,38972399 0,39197024 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,39296034 0,3950626 ! female pregnancy GO:0007565 166 94 0,000 0,39296034 0,39490009 ! sterol metabolic process GO:0016125 166 94 0,000 0,39296034 0,39473771 ! regulation of defense response GO:0031347 171 95 0,000 0,39617962 0,39780798 ! nucleosome organization GO:0034728 143 95 0,000 0,39617962 0,39764454 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,39617962 0,39748124 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,39617962 0,39731807 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,39617962 0,39715503 ! sex differentiation GO:0007548 171 96 0,000 0,39938192 0,40020099 ! response to protein stimulus GO:0051789 158 96 0,000 0,39938192 0,40003691 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,40256732 0,40306228 ! transcription initiation GO:0006352 171 97 0,000 0,40256732 0,40289716 ! mRNA transport GO:0051028 185 100 0,000 0,41202306 0,41219178 ! hormone metabolic process GO:0042445 171 100 0,000 0,41202306 0,41202306