pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6681-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein export from nucleus GO:0046825 6 6 4,000 2,545E-11 5,854E-08 ! organ growth GO:0035265 11 7 4,000 8,87E-11 1,02E-07 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 6,000 3,071E-09 2,355E-06 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 4,074E-09 2,343E-06 GO:0046676|negative regulation of insulin secretion, ! regulation of growth hormone secretion GO:0060123 11 7 3,000 2,828E-08 1,301E-05 ! cell cycle checkpoint GO:0000075 108 64 6,000 5,397E-08 2,069E-05 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 5,633E-08 1,851E-05 ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 3,909E-07 1,124E-04 ! interphase of mitotic cell cycle GO:0051329 156 86 6,000 4,237E-07 1,083E-04 ! interphase GO:0051325 159 88 6,000 4,962E-07 1,141E-04 ! DNA damage checkpoint GO:0000077 53 31 4,000 6,474E-07 1,354E-04 ! carbohydrate homeostasis GO:0033500 39 33 4,000 8,966E-07 1,718E-04 GO:0042593|glucose homeostasis, ! DNA integrity checkpoint GO:0031570 57 34 4,000 1,047E-06 1,852E-04 ! negative regulation of cell growth GO:0030308 106 62 5,000 1,056E-06 1,735E-04 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 1,067E-06 1,636E-04 ! regulation of intracellular protein transport GO:0033157 59 35 4,000 1,216E-06 1,748E-04 ! negative regulation of cell size GO:0045792 108 64 5,000 1,277E-06 1,727E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 1,542E-06 1,971E-04 ! positive regulation of hormone secretion GO:0046887 24 17 3,000 1,845E-06 2,233E-04 ! negative regulation of homeostatic process GO:0032845 28 17 3,000 1,845E-06 2,121E-04 ! negative regulation of organelle organization GO:0010639 115 72 5,000 2,569E-06 2,814E-04 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 3,02E-06 3,157E-04 ! ER overload response GO:0006983 7 6 2,000 3,073E-06 3,073E-04 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 3,092E-06 2,963E-04 ! negative regulation of growth GO:0045926 123 75 5,000 3,268E-06 3,007E-04 ! regulation of insulin secretion GO:0050796 26 21 3,000 4,562E-06 4,036E-04 ! response to UV GO:0009411 75 46 4,000 4,897E-06 4,172E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 5,356E-06 4,4E-04 ! B cell lineage commitment GO:0002326 17 7 2,000 5,356E-06 4,248E-04 ! T cell lineage commitment GO:0002360 12 7 2,000 5,356E-06 4,106E-04 ! negative regulation of telomere maintenance GO:0032205 9 7 2,000 5,356E-06 3,974E-04 ! regulation of DNA replication GO:0006275 75 48 4,000 6,065E-06 4,359E-04 ! negative regulation of DNA replication GO:0008156 35 23 3,000 6,694E-06 4,666E-04 ! regulation of intracellular transport GO:0032386 78 49 4,000 6,726E-06 4,55E-04 ! regulation of protein localization GO:0032880 132 85 5,000 6,796E-06 4,466E-04 ! regulation of multicellular organism growth GO:0040014 65 50 4,000 7,441E-06 4,754E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 8,215E-06 5,106E-04 ! positive regulation of cell migration GO:0030335 92 51 4,000 8,215E-06 4,972E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 8,536E-06 5,034E-04 ! regulation of telomere maintenance GO:0032204 10 8 2,000 8,536E-06 4,908E-04 ! regulation of peptide secretion GO:0002791 34 25 3,000 9,484E-06 5,32E-04 ! regulation of chromosome organization GO:0033044 35 25 3,000 9,484E-06 5,193E-04 ! motor axon guidance GO:0008045 14 9 2,000 1,275E-05 6,821E-04 ! DNA damage response, signal transduction GO:0042770 96 56 4,000 1,307E-05 6,834E-04 ! positive regulation of cell motion GO:0051272 99 56 4,000 1,307E-05 6,683E-04 ! multicellular organism reproduction GO:0032504 83 57 4,000 1,427E-05 7,135E-04 GO:0048609|reproductive process in a multicellular organism, ! response to peptide hormone stimulus GO:0043434 84 57 4,000 1,427E-05 6,983E-04 ! triglyceride metabolic process GO:0006641 34 28 3,000 1,516E-05 7,264E-04 ! activation of MAPK activity GO:0000187 84 59 4,000 1,692E-05 7,941E-04 ! protein sumoylation GO:0016925 12 10 2,000 1,815E-05 8,348E-04 ! regulation of homeostatic process GO:0032844 105 60 4,000 1,838E-05 8,287E-04 ! negative regulation of secretion GO:0051048 49 31 3,000 2,301E-05 1,018E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 3,000 2,619E-05 1,136E-03 ! neutral lipid metabolic process GO:0006638 41 32 3,000 2,619E-05 1,115E-03 GO:0006639|acylglycerol metabolic process, ! response to gamma radiation GO:0010332 20 12 2,000 3,301E-05 1,38E-03 ! glycerol ether metabolic process GO:0006662 44 34 3,000 3,349E-05 1,375E-03 ! response to reactive oxygen species GO:0000302 55 36 3,000 4,219E-05 1,702E-03 ! regulation of hormone secretion GO:0046883 48 36 3,000 4,219E-05 1,673E-03 ! organic ether metabolic process GO:0018904 46 36 3,000 4,219E-05 1,645E-03 ! hormone-mediated signaling GO:0009755 49 36 3,000 4,219E-05 1,617E-03 ! cellular pigmentation GO:0033059 24 13 2,000 4,274E-05 1,612E-03 ! epidermis morphogenesis GO:0048730 29 14 2,000 5,418E-05 2,01E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 5,418E-05 1,978E-03 ! regulation of protein transport GO:0051223 114 76 4,000 5,805E-05 2,086E-03 GO:0070201|regulation of establishment of protein localization, ! negative regulation of cell cycle process GO:0010948 24 15 2,000 6,746E-05 2,387E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 6,746E-05 2,351E-03 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 9,917E-05 3,404E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1E-04 3,383E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1E-04 3,334E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 1,028E-04 3,377E-03 ! cell cycle arrest GO:0007050 150 86 4,000 1,048E-04 3,396E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 1,196E-04 3,819E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 2,000 1,196E-04 3,767E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,414E-04 4,396E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 1,414E-04 4,337E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 1,519E-04 4,596E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,657E-04 4,95E-03 ! positive regulation of secretion GO:0051047 71 51 3,000 1,682E-04 4,959E-03 ! response to light stimulus GO:0009416 153 96 4,000 1,763E-04 5,133E-03 ! cell aging GO:0007569 32 21 2,000 1,926E-04 5,537E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 1,926E-04 5,468E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 1,926E-04 5,402E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 2,221E-04 6,155E-03 ! protein tetramerization GO:0051262 39 22 2,000 2,221E-04 6,082E-03 ! acetyl-CoA metabolic process GO:0006084 33 23 2,000 2,544E-04 6,885E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 2,544E-04 6,805E-03 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 2,544E-04 6,726E-03 ! telomere organization GO:0032200 32 23 2,000 2,544E-04 6,65E-03 GO:0000723|telomere maintenance, ! response to corticosteroid stimulus GO:0031960 36 23 2,000 2,544E-04 6,575E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,891E-04 7,388E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 2,891E-04 7,307E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 2,891E-04 7,228E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 2,891E-04 7,15E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,891E-04 7,074E-03 ! apical protein localization GO:0045176 6 5 1,000 2,891E-04 7E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 2,891E-04 6,927E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 2,891E-04 6,855E-03 ! pyruvate metabolic process GO:0006090 29 24 2,000 2,896E-04 6,798E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 2,896E-04 6,729E-03 ! mitochondrial membrane organization GO:0007006 39 24 2,000 2,896E-04 6,662E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 3,278E-04 7,466E-03 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of transferase activity GO:0051348 105 61 3,000 3,369E-04 7,597E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 4,137E-04 9,237E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 4,321E-04 9,557E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 4,321E-04 9,466E-03 ! pigment granule organization GO:0048753 11 6 1,000 4,321E-04 9,376E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 4,321E-04 9,289E-03 ! male sex determination GO:0030238 9 6 1,000 4,321E-04 9,203E-03 ! spindle checkpoint GO:0031577 14 6 1,000 4,321E-04 9,118E-03 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 4,321E-04 9,035E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 4,321E-04 8,954E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 4,321E-04 8,874E-03 ! response to hydrogen peroxide GO:0042542 42 29 2,000 5,127E-04 0,01043552 ! response to drug GO:0042493 108 69 3,000 5,399E-04 0,01089338 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 6,028E-04 0,01205685 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 6,028E-04 0,01195291 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 6,028E-04 0,01185075 ! microtubule bundle formation GO:0001578 8 7 1,000 6,028E-04 0,01175032 ! regulation of pigmentation during development GO:0048070 15 7 1,000 6,028E-04 0,01165158 ! asymmetric protein localization GO:0008105 8 7 1,000 6,028E-04 0,01155448 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 6,028E-04 0,01145899 ! behavioral fear response GO:0001662 13 7 1,000 6,028E-04 0,01136506 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 6,028E-04 0,01127267 ! response to UV-B GO:0010224 11 7 1,000 6,028E-04 0,01118176 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 6,028E-04 0,0110923 ! response to tumor cell GO:0002347 12 7 1,000 6,028E-04 0,01100427 ! peptidyl-threonine modification GO:0018210 18 7 1,000 6,028E-04 0,01091762 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 6,028E-04 0,01083233 ! mammary gland development GO:0030879 57 31 2,000 6,258E-04 0,01115703 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 6,258E-04 0,0110712 ! negative regulation of transport GO:0051051 116 73 3,000 6,686E-04 0,01173937 ! regulation of muscle development GO:0048634 48 32 2,000 6,878E-04 0,0119842 ! mitotic sister chromatid segregation GO:0000070 45 32 2,000 6,878E-04 0,0118941 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 6,878E-04 0,01180533 ! response to inorganic substance GO:0010035 115 75 3,000 7,405E-04 0,01261616 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 7,536E-04 0,01274472 ! sister chromatid segregation GO:0000819 46 33 2,000 7,536E-04 0,01265169 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 8,009E-04 0,01334908 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 8,009E-04 0,01325304 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 8,009E-04 0,01315838 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 8,009E-04 0,01306506 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 8,009E-04 0,01297305 ! melanin metabolic process GO:0006582 12 8 1,000 8,009E-04 0,01288233 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 8,009E-04 0,01279287 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 8,009E-04 0,01270464 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 8,009E-04 0,01261762 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 8,009E-04 0,01253179 ! regulation of embryonic development GO:0045995 16 8 1,000 8,009E-04 0,01244712 ! gland development GO:0048732 148 77 3,000 8,177E-04 0,01262214 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 8,233E-04 0,01262376 ! neuron migration GO:0001764 46 34 2,000 8,233E-04 0,01254016 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 8,233E-04 0,01245766 ! regulation of developmental growth GO:0048638 13 9 1,000 1,026E-03 0,01542567 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,026E-03 0,0153255 ! regulation of glycolysis GO:0006110 15 9 1,000 1,026E-03 0,01522663 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,026E-03 0,01512902 ! T cell selection GO:0045058 18 9 1,000 1,026E-03 0,01503266 ! telomere maintenance via telomerase GO:0007004 12 9 1,000 1,026E-03 0,01493752 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 1,000 1,026E-03 0,01484357 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,026E-03 0,0147508 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,026E-03 0,01465918 ! oocyte differentiation GO:0009994 12 9 1,000 1,026E-03 0,01456869 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,026E-03 0,01447931 ! spleen development GO:0048536 15 9 1,000 1,026E-03 0,01439102 ! response to nicotine GO:0035094 16 9 1,000 1,026E-03 0,0143038 ! localization within membrane GO:0051668 15 9 1,000 1,026E-03 0,01421764 ! pigmentation GO:0043473 74 38 2,000 1,143E-03 0,01573574 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,233E-03 0,01687921 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 1,233E-03 0,01677933 ! negative regulation of muscle development GO:0048635 12 10 1,000 1,278E-03 0,0172925 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,278E-03 0,01719137 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,278E-03 0,01709143 ! pathogenesis GO:0009405 13 10 1,000 1,278E-03 0,01699263 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,278E-03 0,01689497 ! response to X-ray GO:0010165 16 10 1,000 1,278E-03 0,01679843 ! B cell proliferation GO:0042100 14 10 1,000 1,278E-03 0,01670298 ! fear response GO:0042596 16 10 1,000 1,278E-03 0,01660862 ! negative regulation of ossification GO:0030279 19 10 1,000 1,278E-03 0,01651531 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,278E-03 0,01642305 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,278E-03 0,01633181 ! RNA-dependent DNA replication GO:0006278 13 10 1,000 1,278E-03 0,01624158 ! DNA methylation GO:0006306 15 10 1,000 1,278E-03 0,01615234 GO:0006305|DNA alkylation, ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,278E-03 0,01606407 GO:0043470|regulation of carbohydrate catabolic process, ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 1,328E-03 0,01659579 ! T cell differentiation GO:0030217 65 40 2,000 1,328E-03 0,01650608 ! B cell differentiation GO:0030183 62 40 2,000 1,328E-03 0,01641734 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 1,328E-03 0,01632955 ! anatomical structure homeostasis GO:0060249 136 88 3,000 1,346E-03 0,01647224 ! hormone metabolic process GO:0042445 121 90 3,000 1,463E-03 0,01780656 ! mitochondrial transport GO:0006839 60 42 2,000 1,531E-03 0,0185285 ! virus-host interaction GO:0019048 17 11 1,000 1,557E-03 0,018745 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,557E-03 0,01864737 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 1,557E-03 0,01855075 ! plasma membrane organization GO:0007009 18 11 1,000 1,557E-03 0,01845513 ! focal adhesion formation GO:0048041 24 11 1,000 1,557E-03 0,01836048 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,557E-03 0,01826681 ! adult heart development GO:0007512 11 11 1,000 1,557E-03 0,01817408 ! histone deacetylation GO:0016575 13 11 1,000 1,557E-03 0,0180823 ! T cell homeostasis GO:0043029 20 11 1,000 1,557E-03 0,01799143 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 1,557E-03 0,01790147 ! digestive tract morphogenesis GO:0048546 15 11 1,000 1,557E-03 0,01781241 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,557E-03 0,01772423 GO:0042130|negative regulation of T cell proliferation, ! regulation of gene-specific transcription GO:0032583 69 43 2,000 1,639E-03 0,01856964 ! response to insulin stimulus GO:0032868 63 43 2,000 1,639E-03 0,01847862 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 1,639E-03 0,01838848 ! response to oxidative stress GO:0006979 141 94 3,000 1,718E-03 0,01917853 ! glycolysis GO:0006096 53 44 2,000 1,752E-03 0,01946685 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 1,752E-03 0,01937326 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,861E-03 0,02048407 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 1,861E-03 0,02038652 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,861E-03 0,0202899 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,861E-03 0,0201942 ! gland morphogenesis GO:0022612 23 12 1,000 1,861E-03 0,02009939 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,861E-03 0,02000547 ! positive regulation of homeostatic process GO:0032846 15 12 1,000 1,861E-03 0,01991242 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,87E-03 0,0199101 ! histone modification GO:0016570 68 46 2,000 1,992E-03 0,02111812 ! covalent chromatin modification GO:0016569 75 47 2,000 2,12E-03 0,02236673 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 2,12E-03 0,0222646 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 2,12E-03 0,0221634 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,192E-03 0,02281308 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,192E-03 0,02271032 ! regulation of cellular pH GO:0030641 20 13 1,000 2,192E-03 0,02260848 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 2,192E-03 0,02250755 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,192E-03 0,02240752 ! positive regulation of growth GO:0045927 67 50 2,000 2,533E-03 0,0257744 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 2,548E-03 0,02582028 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 2,548E-03 0,02570703 ! response to cAMP GO:0051591 19 14 1,000 2,548E-03 0,02559477 ! cellular response to starvation GO:0009267 21 14 1,000 2,548E-03 0,02548349 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 2,548E-03 0,02537317 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 2,548E-03 0,02526381 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 2,548E-03 0,02515538 ! G1/S transition checkpoint GO:0031575 33 14 1,000 2,548E-03 0,02504788 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 2,548E-03 0,02494129 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 2,548E-03 0,02483561 ! positive regulation of organelle organization GO:0010638 82 51 2,000 2,68E-03 0,02601225 ! aging GO:0007568 79 52 2,000 2,833E-03 0,02738151 ! nucleotide-excision repair GO:0006289 64 52 2,000 2,833E-03 0,02726695 ! metencephalon development GO:0022037 19 15 1,000 2,93E-03 0,0280794 ! skin development GO:0043588 25 15 1,000 2,93E-03 0,02796289 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 2,93E-03 0,02784734 ! regulation of neurotransmitter secretion GO:0046928 26 15 1,000 2,93E-03 0,02773274 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 2,93E-03 0,02761908 ! biomineral formation GO:0031214 18 15 1,000 2,93E-03 0,02750635 ! dopamine metabolic process GO:0042417 30 15 1,000 2,93E-03 0,02739453 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 2,93E-03 0,02728362 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 2,93E-03 0,02717361 ! defense response to virus GO:0051607 27 15 1,000 2,93E-03 0,02706448 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 2,93E-03 0,02695622 ! regulation of mitosis GO:0007088 84 54 2,000 3,155E-03 0,02891299 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 2,000 3,155E-03 0,02879825 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 3,337E-03 0,0303344 ! protein amino acid deacetylation GO:0006476 20 16 1,000 3,337E-03 0,03021498 ! protein amino acid acetylation GO:0006473 28 16 1,000 3,337E-03 0,03009648 ! regulation of protein binding GO:0043393 27 16 1,000 3,337E-03 0,02997892 ! oogenesis GO:0048477 23 16 1,000 3,337E-03 0,02986227 ! G1 phase GO:0051318 27 16 1,000 3,337E-03 0,02974653 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 3,337E-03 0,02963167 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 3,499E-03 0,03095061 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 3,679E-03 0,03241798 ! chromosome segregation GO:0007059 83 57 2,000 3,679E-03 0,03229425 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 3,768E-03 0,03295516 ! forelimb morphogenesis GO:0035136 19 17 1,000 3,768E-03 0,03283033 ! regulation of viral genome replication GO:0045069 24 17 1,000 3,768E-03 0,03270645 ! cell-substrate junction assembly GO:0007044 39 17 1,000 3,768E-03 0,03258349 ! neuromuscular junction development GO:0007528 23 17 1,000 3,768E-03 0,03246145 ! negative regulation of kinase activity GO:0033673 100 58 2,000 3,864E-03 0,03316349 ! viral reproductive process GO:0022415 87 58 2,000 3,864E-03 0,0330402 ! positive regulation of DNA replication GO:0045740 29 18 1,000 4,224E-03 0,03598606 ! prostaglandin metabolic process GO:0006693 31 18 1,000 4,224E-03 0,03585327 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 1,000 4,224E-03 0,03572145 ! cellular response to nutrient levels GO:0031669 27 18 1,000 4,224E-03 0,0355906 ! gut development GO:0048565 26 18 1,000 4,224E-03 0,03546071 ! negative regulation of T cell activation GO:0050868 25 18 1,000 4,224E-03 0,03533176 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 4,224E-03 0,03520375 ! homeostasis of number of cells GO:0048872 84 61 2,000 4,455E-03 0,03698874 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 4,705E-03 0,03892465 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 4,705E-03 0,03878514 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 4,705E-03 0,03864662 ! response to alkaloid GO:0043279 32 19 1,000 4,705E-03 0,03850909 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 4,705E-03 0,03837253 ! vesicle docking during exocytosis GO:0006904 24 19 1,000 4,705E-03 0,03823694 ! response to starvation GO:0042594 30 19 1,000 4,705E-03 0,0381023 ! sex determination GO:0007530 29 19 1,000 4,705E-03 0,03796861 ! renal system process GO:0003014 35 19 1,000 4,705E-03 0,03783585 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 4,705E-03 0,03770402 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 4,705E-03 0,0375731 ! viral reproduction GO:0016032 92 63 2,000 4,877E-03 0,03881419 ! hexose catabolic process GO:0019320 82 64 2,000 5,097E-03 0,04042463 ! hindlimb morphogenesis GO:0035137 32 20 1,000 5,209E-03 0,04117196 ! regulation of neurotransmitter transport GO:0051588 35 20 1,000 5,209E-03 0,04103096 ! response to ethanol GO:0045471 37 20 1,000 5,209E-03 0,04089093 ! multicellular organismal response to stress GO:0033555 32 20 1,000 5,209E-03 0,04075184 ! fatty acid beta-oxidation GO:0006635 31 20 1,000 5,209E-03 0,0406137 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 5,209E-03 0,04047649 ! DNA modification GO:0006304 28 20 1,000 5,209E-03 0,04034021 ! collagen fibril organization GO:0030199 45 20 1,000 5,209E-03 0,04020484 ! positive regulation of B cell activation GO:0050871 31 20 1,000 5,209E-03 0,04007037 ! B cell activation GO:0042113 104 65 2,000 5,323E-03 0,04080849 ! protein oligomerization GO:0051259 100 65 2,000 5,323E-03 0,04067292 ! axon guidance GO:0007411 99 66 2,000 5,555E-03 0,04230335 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 5,737E-03 0,04354976 ! gluconeogenesis GO:0006094 25 21 1,000 5,737E-03 0,0434065 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 5,737E-03 0,04326419 ! protein amino acid acylation GO:0043543 37 21 1,000 5,737E-03 0,0431228 ! vesicle docking GO:0048278 27 21 1,000 5,737E-03 0,04298234 ! dendrite development GO:0016358 35 21 1,000 5,737E-03 0,04284278 ! ovarian follicle development GO:0001541 30 21 1,000 5,737E-03 0,04270413 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 5,737E-03 0,04256638 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 5,737E-03 0,04242951 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 5,737E-03 0,04229352 ! response to cytokine stimulus GO:0034097 47 21 1,000 5,737E-03 0,04215839 ! acetyl-CoA catabolic process GO:0046356 31 21 1,000 5,737E-03 0,04202413 GO:0006099|tricarboxylic acid cycle, ! protein import into nucleus, translocation GO:0000060 36 22 1,000 6,289E-03 0,04591761 ! viral genome replication GO:0019079 29 22 1,000 6,289E-03 0,0457723 ! molting cycle process GO:0022404 40 22 1,000 6,289E-03 0,04562791 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 6,289E-03 0,04548443 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 6,289E-03 0,04534184 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 6,289E-03 0,04520015 ! ureteric bud development GO:0001657 32 22 1,000 6,289E-03 0,04505934 ! coenzyme catabolic process GO:0009109 33 22 1,000 6,289E-03 0,0449194 ! leukocyte homeostasis GO:0001776 33 22 1,000 6,289E-03 0,04478033 ! neural tube closure GO:0001843 33 22 1,000 6,289E-03 0,04464212 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! response to metal ion GO:0010038 103 70 2,000 6,542E-03 0,04629637 ! lymphocyte differentiation GO:0030098 113 71 2,000 6,804E-03 0,04800325 ! monosaccharide catabolic process GO:0046365 91 71 2,000 6,804E-03 0,04785645 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 6,863E-03 0,04812757 ! myelination GO:0042552 35 23 1,000 6,863E-03 0,04798129 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 6,863E-03 0,04783589 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 6,863E-03 0,04769137 ! regulation of viral reproduction GO:0050792 32 23 1,000 6,863E-03 0,04754772 ! interaction with host GO:0051701 37 23 1,000 6,863E-03 0,04740494 ! lymphocyte proliferation GO:0046651 36 23 1,000 6,863E-03 0,04726301 ! cellular response to oxidative stress GO:0034599 33 23 1,000 6,863E-03 0,04712192 ! response to hypoxia GO:0001666 132 72 2,000 7,072E-03 0,04841069 ! tube morphogenesis GO:0035239 118 73 2,000 7,347E-03 0,05014005 ! mitochondrion organization GO:0007005 104 73 2,000 7,347E-03 0,04999171 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 7,347E-03 0,04984424 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 7,461E-03 0,05047165 ! response to toxin GO:0009636 38 24 1,000 7,461E-03 0,05032364 ! primary neural tube formation GO:0014020 35 24 1,000 7,461E-03 0,05017649 ! negative regulation of cell development GO:0010721 56 24 1,000 7,461E-03 0,05003021 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 7,461E-03 0,04988477 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 7,461E-03 0,04974018 ! response to oxygen levels GO:0070482 137 74 2,000 7,627E-03 0,0507016 ! response to nutrient GO:0007584 104 75 2,000 7,914E-03 0,05245745 ! male gonad development GO:0008584 33 25 1,000 8,081E-03 0,05341091 ! positive regulation of nuclear division GO:0051785 39 25 1,000 8,081E-03 0,05325787 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 8,081E-03 0,05310571 ! leukocyte proliferation GO:0070661 39 25 1,000 8,081E-03 0,05295441 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 8,081E-03 0,05280397 ! regulation of pH GO:0006885 36 26 1,000 8,724E-03 0,05684182 ! post-embryonic development GO:0009791 42 26 1,000 8,724E-03 0,05668125 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 8,724E-03 0,05652158 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 8,724E-03 0,05636282 ! T cell activation GO:0042110 134 79 2,000 9,125E-03 0,05879084 ! membrane docking GO:0022406 39 27 1,000 9,389E-03 0,06031917 ! catechol metabolic process GO:0009712 43 27 1,000 9,389E-03 0,06015115 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! lipid oxidation GO:0034440 38 27 1,000 9,389E-03 0,05998406 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 1,000 9,389E-03 0,0598179 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 9,389E-03 0,05965266 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 9,389E-03 0,05948833 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 9,389E-03 0,0593249 ! alcohol catabolic process GO:0046164 104 80 2,000 9,444E-03 0,0595109 ! regulation of cell cycle process GO:0010564 122 81 2,000 9,769E-03 0,06139193 ! phenol metabolic process GO:0018958 44 28 1,000 0,01007553 0,06314364 ! cell junction assembly GO:0034329 56 28 1,000 0,01007553 0,06297205 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01007553 0,06280139 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01007553 0,06263166 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01007553 0,06246284 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01007553 0,06229493 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01007553 0,06212792 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01007553 0,0619618 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01007553 0,06179657 ! ossification GO:0001503 134 82 2,000 0,010101 0,06178803 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 2,000 0,01043917 0,06368723 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01078385 0,06561605 ! ovulation cycle process GO:0022602 41 29 1,000 0,01078389 0,0654431 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,01078389 0,06527089 ! tissue homeostasis GO:0001894 42 29 1,000 0,01078389 0,06509957 GO:0048871|multicellular organismal homeostasis, ! regulation of membrane potential GO:0042391 128 85 2,000 0,01113508 0,06704368 ! collagen metabolic process GO:0032963 40 30 1,000 0,01151363 0,06914192 ! spindle organization GO:0007051 37 30 1,000 0,01151363 0,06896186 ! ovulation cycle GO:0042698 43 30 1,000 0,01151363 0,06878274 ! hindbrain development GO:0030902 45 30 1,000 0,01151363 0,06860454 ! fatty acid catabolic process GO:0009062 43 30 1,000 0,01151363 0,06842727 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01151363 0,06825091 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01151363 0,06807546 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01151363 0,06790091 ! response to heat GO:0009408 41 30 1,000 0,01151363 0,06772725 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,01185724 0,06957052 GO:0060538|skeletal muscle organ development, ! glial cell differentiation GO:0010001 55 31 1,000 0,01226452 0,07177709 ! odontogenesis GO:0042476 50 31 1,000 0,01226452 0,07159491 ! segmentation GO:0035282 41 31 1,000 0,01226452 0,07141366 ! metanephros development GO:0001656 58 31 1,000 0,01226452 0,07123332 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01226452 0,07105389 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01226452 0,07087536 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,0126058 0,07266499 ! reproductive developmental process GO:0003006 127 89 2,000 0,0126058 0,07248333 ! leukocyte differentiation GO:0002521 143 90 2,000 0,01299002 0,07450636 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,01299002 0,07432102 ! meiosis I GO:0007127 52 32 1,000 0,0130363 0,07440073 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,0130363 0,07421657 ! peripheral nervous system development GO:0007422 53 32 1,000 0,0130363 0,07403332 ! regulation of protein stability GO:0031647 48 32 1,000 0,0130363 0,07385097 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,0130363 0,07366952 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,0130363 0,07348896 ! cell fate commitment GO:0045165 141 92 2,000 0,01377845 0,07748274 ! cell junction organization GO:0034330 63 33 1,000 0,01382873 0,07757582 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01382873 0,07738708 ! female gonad development GO:0008585 49 33 1,000 0,01382873 0,07719924 ! positive regulation of cell development GO:0010720 54 33 1,000 0,01382873 0,07701232 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01382873 0,0768263 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01382873 0,07664118 ! cytokinesis GO:0000910 52 33 1,000 0,01382873 0,07645694 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,01418269 0,07822585 ! carbohydrate catabolic process GO:0016052 121 93 2,000 0,01418269 0,0780387 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01464157 0,08037141 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01464157 0,08018005 ! female gamete generation GO:0007292 43 34 1,000 0,01464157 0,0799896 ! aerobic respiration GO:0009060 47 34 1,000 0,01464157 0,07980005 ! regulation of binding GO:0051098 151 95 2,000 0,01501126 0,08162153 ! in utero embryonic development GO:0001701 147 96 2,000 0,01543563 0,08373102 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,01543563 0,08353401 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,01547458 0,08354821 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01547458 0,08335255 ! pigment metabolic process GO:0042440 61 35 1,000 0,01547458 0,0831578 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,01547458 0,08296396 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 0,01586674 0,08486859 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01632752 0,08713062 GO:0090047|positive regulation of transcription regulator activity, ! neural tube development GO:0021915 50 36 1,000 0,01632752 0,08692892 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01632752 0,08672816 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,01632752 0,08652833 GO:0006073|cellular glucan metabolic process, ! extracellular structure organization GO:0043062 156 99 2,000 0,01674919 0,08855896 ! gliogenesis GO:0042063 71 38 1,000 0,01809224 0,09544071 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,01809224 0,09522231 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,01809224 0,09500491 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,01809224 0,09478849 ! mesenchymal cell development GO:0014031 64 38 1,000 0,01809224 0,09457307 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,01900355 0,0991115 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,01900355 0,09888727 ! male sex differentiation GO:0046661 53 39 1,000 0,01900355 0,09866405 ! chromatin remodeling GO:0006338 68 39 1,000 0,01900355 0,09844183 ! developmental growth GO:0048589 62 39 1,000 0,01900355 0,09822061 ! synapse organization GO:0050808 55 39 1,000 0,01900355 0,09800039 ! response to calcium ion GO:0051592 58 40 1,000 0,01993386 0,10256798 ! double-strand break repair GO:0006302 67 40 1,000 0,01993386 0,10233903 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01993386 0,1021111 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,02088294 0,10673503 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02088294 0,10649836 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,02088294 0,10626275 ! biopolymer methylation GO:0043414 62 41 1,000 0,02088294 0,10602817 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,02185056 0,11069665 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,02185056 0,11045336 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02185056 0,11021114 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,02185056 0,10996998 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,02185056 0,10972987 ! regulation of cell shape GO:0008360 78 42 1,000 0,02185056 0,10949081 ! positive regulation of binding GO:0051099 59 43 1,000 0,02283649 0,11418244 ! activation of caspase activity GO:0006919 65 43 1,000 0,02283649 0,11393475 ! vesicle organization GO:0016050 79 43 1,000 0,02283649 0,11368814 ! methylation GO:0032259 64 43 1,000 0,02283649 0,11344259 ! regulation of action potential GO:0001508 71 44 1,000 0,02384051 0,11817494 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,02384051 0,1179208 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,02384051 0,11766775 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,02590195 0,12756847 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,02590195 0,12729589 ! regulation of ossification GO:0030278 71 46 1,000 0,02590195 0,12702447 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02688015 0,13154114 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02688015 0,13126186 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02688015 0,13098376 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02688015 0,13070684 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02688015 0,13043109 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02688015 0,13015649 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02688015 0,12988306 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02688015 0,12961076 ! sleep GO:0030431 11 5 0,000 0,02688015 0,12933961 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02688015 0,12906959 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02688015 0,1288007 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02688015 0,12853292 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02688015 0,12826625 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02688015 0,12800069 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02688015 0,12773623 ! tongue development GO:0043586 6 5 0,000 0,02688015 0,12747285 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02688015 0,12721057 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02688015 0,12694935 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02688015 0,12668921 ! cobalt ion transport GO:0006824 9 5 0,000 0,02688015 0,12643013 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02688015 0,12617211 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02688015 0,12591514 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02688015 0,12565922 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02688015 0,12540433 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02688015 0,12515048 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02688015 0,12489765 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02688015 0,12464584 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02688015 0,12439504 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02688015 0,12414525 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02688015 0,12389646 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02688015 0,12364867 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02688015 0,12340187 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02688015 0,12315605 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02688015 0,1229112 ! malate metabolic process GO:0006108 7 5 0,000 0,02688015 0,12266733 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02688015 0,12242443 ! behavioral response to pain GO:0048266 7 5 0,000 0,02688015 0,12218248 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02688015 0,12194149 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02688015 0,12170145 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02688015 0,12146235 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02688015 0,12122419 ! mating behavior GO:0007617 6 5 0,000 0,02688015 0,12098696 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02688015 0,12075065 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02688015 0,12051527 ! rhythmic behavior GO:0007622 12 5 0,000 0,02688015 0,12028081 ! copulation GO:0007620 7 5 0,000 0,02688015 0,12004725 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02688015 0,1198146 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02688015 0,11958285 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02688015 0,119352 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02688015 0,11912203 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02688015 0,11889295 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02688015 0,11866475 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02688015 0,11843742 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02688015 0,11821096 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02688015 0,11798537 ! response to protozoan GO:0001562 9 5 0,000 0,02688015 0,11776064 ! lymph vessel development GO:0001945 7 5 0,000 0,02688015 0,11753676 ! endochondral ossification GO:0001958 12 5 0,000 0,02688015 0,11731373 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02688015 0,11709154 ! parathyroid gland development GO:0060017 8 5 0,000 0,02688015 0,1168702 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02688015 0,11664969 ! anagen GO:0042640 6 5 0,000 0,02688015 0,11643001 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02688015 0,11621116 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02688015 0,11599312 ! nuclear migration GO:0007097 10 5 0,000 0,02688015 0,11577591 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02688015 0,1155595 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02688015 0,11534391 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02688015 0,11512911 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02688015 0,11491512 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02688015 0,11470192 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02688015 0,11448951 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02688015 0,11427788 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02688015 0,11406704 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02688015 0,11385697 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02688015 0,11364767 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02688015 0,11343915 ! ovulation GO:0030728 6 5 0,000 0,02688015 0,11323138 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02688015 0,11302438 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02688015 0,11281813 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02688015 0,11261263 ! response to pH GO:0009268 9 5 0,000 0,02688015 0,11240788 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02688015 0,11220387 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02688015 0,11200061 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02688015 0,11179807 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02688015 0,11159627 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02688015 0,1113952 ! polyol catabolic process GO:0046174 7 5 0,000 0,02688015 0,11119485 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02688015 0,11099521 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02688015 0,1107963 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02688015 0,11059809 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02688015 0,1104006 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02688015 0,11020381 ! urea metabolic process GO:0019627 6 5 0,000 0,02688015 0,11000771 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02688015 0,10981232 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02688015 0,10961761 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02688015 0,1094236 ! neutrophil activation GO:0042119 5 5 0,000 0,02688015 0,10923027 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02688015 0,10903763 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02688015 0,10884566 ! response to food GO:0032094 5 5 0,000 0,02688015 0,10865437 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02688015 0,10846375 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02688015 0,10827379 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02688015 0,1080845 ! forebrain neuron development GO:0021884 7 5 0,000 0,02688015 0,10789587 ! melanosome organization GO:0032438 7 5 0,000 0,02688015 0,1077079 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02688015 0,10752058 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02688015 0,10733391 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02688015 0,10714789 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02688015 0,10696252 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02688015 0,10677778 ! nucleoside transport GO:0015858 6 5 0,000 0,02688015 0,10659368 ! nucleoside salvage GO:0043174 7 5 0,000 0,02688015 0,10641021 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02688015 0,10622738 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02688015 0,10604517 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02688015 0,10586359 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02688015 0,10568262 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02688015 0,10550228 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02688015 0,10532255 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02688015 0,10514343 ! depyrimidination GO:0045008 8 5 0,000 0,02688015 0,10496491 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02688015 0,10478701 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02688015 0,1046097 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02688015 0,104433 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02688015 0,10425689 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02688015 0,10408137 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02688015 0,10390644 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02688015 0,10373211 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02688015 0,10355835 ! monocyte differentiation GO:0030224 8 5 0,000 0,02688015 0,10338518 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02688015 0,10321258 ! centrosome duplication GO:0051298 5 5 0,000 0,02688015 0,10304056 ! response to UV-C GO:0010225 6 5 0,000 0,02688015 0,10286911 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02688015 0,10269823 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02688015 0,10252792 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02688015 0,10235817 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02688015 0,10218898 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02688015 0,10202035 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02688015 0,10185228 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02688015 0,10168476 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02688015 0,10151779 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02688015 0,10135137 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02688015 0,10118549 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02688015 0,10102015 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02688015 0,10085536 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02688015 0,1006911 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02688015 0,10052737 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02688015 0,10036418 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02688015 0,10020151 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02688015 0,10003938 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02688015 0,09987776 ! neural tube patterning GO:0021532 6 5 0,000 0,02688015 0,09971667 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02688015 0,09955609 ! histone demethylation GO:0016577 9 5 0,000 0,02688015 0,09939604 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02688015 0,09923649 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02688015 0,09907746 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02688015 0,09891894 ! enteric nervous system development GO:0048484 8 5 0,000 0,02688015 0,09876092 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02688015 0,0986034 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02688015 0,09844639 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02688015 0,09828988 ! transcription termination GO:0006353 8 5 0,000 0,02688015 0,09813386 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02688015 0,09797834 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02688015 0,09782331 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02688015 0,09766878 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02688015 0,09751472 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02688015 0,09736116 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02688015 0,09720807 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02688015 0,09705547 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02688015 0,09690335 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02688015 0,0967517 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02688015 0,09660052 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02688015 0,09644982 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02688015 0,09629959 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02688015 0,09614982 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02688015 0,09600052 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02688015 0,09585168 ! glial cell migration GO:0008347 10 5 0,000 0,02688015 0,0957033 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02688015 0,09555539 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02688015 0,09540792 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02688015 0,09526092 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02688015 0,09511436 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02688015 0,09496826 ! neural plate development GO:0001840 6 5 0,000 0,02688015 0,0948226 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02688015 0,09467739 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02688015 0,09453262 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02688015 0,0943883 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02688015 0,09424441 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02688015 0,09410097 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02688015 0,09395796 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02688015 0,09381538 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02688015 0,09367323 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02688015 0,09353152 ! spindle assembly GO:0051225 5 5 0,000 0,02688015 0,09339023 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02688015 0,09324937 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02688015 0,09310894 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02688015 0,09296892 ! organ regeneration GO:0031100 7 5 0,000 0,02688015 0,09282933 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02688015 0,09269016 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02688015 0,0925514 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02688015 0,09241306 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02688015 0,09227513 GO:0055081|anion homeostasis, ! viral infectious cycle GO:0019058 71 47 1,000 0,02695892 0,09240763 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,02695892 0,09227012 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,02695892 0,09213302 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,02695892 0,09199632 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,02803312 0,09552025 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,02803312 0,09537894 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,02803312 0,09523806 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,02803312 0,09509759 ! heart morphogenesis GO:0003007 65 48 1,000 0,02803312 0,09495753 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,02803312 0,09481789 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,02912431 0,09836405 ! RNA elongation GO:0006354 62 49 1,000 0,02912431 0,09821982 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,02912431 0,09807601 ! germ cell development GO:0007281 68 49 1,000 0,02912431 0,09793263 ! regulation of actin filament length GO:0030832 72 50 1,000 0,0302323 0,10150991 ! ear development GO:0043583 72 50 1,000 0,0302323 0,10136194 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,0302323 0,10121439 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,0302323 0,10106728 ! lipid modification GO:0030258 73 50 1,000 0,0302323 0,10092059 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03135687 0,10452289 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,03135687 0,10437163 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,03135687 0,1042208 ! tRNA transcription GO:0009304 11 6 0,000 0,03216975 0,10676828 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03216975 0,10661444 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03216975 0,10646104 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03216975 0,10630808 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03216975 0,10615555 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03216975 0,10600347 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03216975 0,10585182 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03216975 0,1057006 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03216975 0,10554982 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03216975 0,10539946 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03216975 0,10524953 ! prostate gland development GO:0030850 9 6 0,000 0,03216975 0,10510003 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03216975 0,10495095 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03216975 0,1048023 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03216975 0,10465406 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03216975 0,10450624 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03216975 0,10435884 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03216975 0,10421186 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03216975 0,10406529 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03216975 0,10391913 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03216975 0,10377338 ! neuron adhesion GO:0007158 9 6 0,000 0,03216975 0,10362804 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03216975 0,10348311 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03216975 0,10333858 ! signal peptide processing GO:0006465 8 6 0,000 0,03216975 0,10319445 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03216975 0,10305073 ! mRNA stabilization GO:0048255 15 6 0,000 0,03216975 0,1029074 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03216975 0,10276447 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03216975 0,10262194 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03216975 0,10247981 ! opsonization GO:0008228 8 6 0,000 0,03216975 0,10233806 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03216975 0,10219671 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03216975 0,10205575 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03216975 0,10191518 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03216975 0,10177499 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03216975 0,10163519 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03216975 0,10149578 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03216975 0,10135674 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03216975 0,10121809 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03216975 0,10107981 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03216975 0,10094191 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03216975 0,10080439 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03216975 0,10066724 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03216975 0,10053046 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03216975 0,10039406 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03216975 0,10025802 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03216975 0,10012236 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03216975 0,09998706 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03216975 0,09985212 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03216975 0,09971755 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03216975 0,09958334 ! thymic T cell selection GO:0045061 12 6 0,000 0,03216975 0,09944949 ! protein lipoylation GO:0009249 10 6 0,000 0,03216975 0,099316 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03216975 0,09918287 ! drug transport GO:0015893 6 6 0,000 0,03216975 0,09905009 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03216975 0,09891767 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03216975 0,09878561 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03216975 0,09865389 ! histidine metabolic process GO:0006547 6 6 0,000 0,03216975 0,09852253 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03216975 0,09839152 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03216975 0,09826085 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03216975 0,09813053 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03216975 0,09800056 ! adenohypophysis development GO:0021984 10 6 0,000 0,03216975 0,09787093 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03216975 0,09774164 ! hyperosmotic response GO:0006972 8 6 0,000 0,03216975 0,09761269 ! microtubule nucleation GO:0007020 10 6 0,000 0,03216975 0,09748409 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03216975 0,09735582 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03216975 0,09722789 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03216975 0,09710029 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03216975 0,09697303 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03216975 0,0968461 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03216975 0,0967195 ! response to dietary excess GO:0002021 7 6 0,000 0,03216975 0,09659324 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03216975 0,0964673 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03216975 0,09634169 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03216975 0,09621641 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03216975 0,09609146 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03216975 0,09596682 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03216975 0,09584251 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03216975 0,09571853 ! neuron apoptosis GO:0051402 8 6 0,000 0,03216975 0,09559486 ! organic alcohol transport GO:0015850 9 6 0,000 0,03216975 0,09547151 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03216975 0,09534848 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03216975 0,09522577 ! carnitine transport GO:0015879 8 6 0,000 0,03216975 0,09510337 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03216975 0,09498128 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03216975 0,09485951 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03216975 0,09473805 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03216975 0,09461691 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03216975 0,09449607 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03216975 0,09437554 ! parturition GO:0007567 12 6 0,000 0,03216975 0,09425531 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03216975 0,0941354 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03216975 0,09401578 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03216975 0,09389647 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03216975 0,09377747 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03216975 0,09365876 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03216975 0,09354036 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03216975 0,09342225 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03216975 0,09330444 ! macrophage differentiation GO:0030225 10 6 0,000 0,03216975 0,09318693 ! astrocyte development GO:0014002 14 6 0,000 0,03216975 0,09306971 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03216975 0,09295279 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03216975 0,09283616 ! interaction with symbiont GO:0051702 8 6 0,000 0,03216975 0,09271983 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03216975 0,09260378 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03216975 0,09248803 ! eating behavior GO:0042755 6 6 0,000 0,03216975 0,09237256 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03216975 0,09225738 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03216975 0,09214249 ! response to copper ion GO:0046688 9 6 0,000 0,03216975 0,09202789 ! DNA topological change GO:0006265 8 6 0,000 0,03216975 0,09191357 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03216975 0,09179953 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03216975 0,09168578 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03216975 0,0915723 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03216975 0,09145911 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03216975 0,0913462 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03216975 0,09123356 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03216975 0,09112121 ! gas homeostasis GO:0033483 11 6 0,000 0,03216975 0,09100913 ! hair follicle maturation GO:0048820 7 6 0,000 0,03216975 0,09089732 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03216975 0,09078579 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03216975 0,09067454 ! Schwann cell development GO:0014044 14 6 0,000 0,03216975 0,09056355 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03216975 0,09045284 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03216975 0,09034239 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03216975 0,09023222 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03216975 0,09012232 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03216975 0,09001268 ! histone ubiquitination GO:0016574 7 6 0,000 0,03216975 0,08990331 ! regulation of meiosis GO:0040020 10 6 0,000 0,03216975 0,0897942 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03216975 0,08968536 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03216975 0,08957678 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03216975 0,08946847 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03216975 0,08936041 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03216975 0,08925262 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03216975 0,08914509 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03216975 0,08903781 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03216975 0,08893079 ! receptor internalization GO:0031623 9 6 0,000 0,03216975 0,08882403 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03216975 0,08871753 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03216975 0,08861128 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03216975 0,08850529 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03216975 0,08839955 ! protein deubiquitination GO:0016579 8 6 0,000 0,03216975 0,08829406 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03216975 0,08818882 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03216975 0,08808383 ! axonal fasciculation GO:0007413 9 6 0,000 0,03216975 0,0879791 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03216975 0,08787461 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03216975 0,08777037 ! midbrain development GO:0030901 6 6 0,000 0,03216975 0,08766638 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03216975 0,08756263 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03216975 0,08745913 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03216975 0,08735587 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03216975 0,08725285 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03216975 0,08715008 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03216975 0,08704755 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03216975 0,08694527 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03216975 0,08684322 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03216975 0,08674141 ! adult feeding behavior GO:0008343 6 6 0,000 0,03216975 0,08663984 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03216975 0,0865385 ! blastocyst growth GO:0001832 15 6 0,000 0,03216975 0,08643741 ! pigment granule transport GO:0051904 12 6 0,000 0,03216975 0,08633655 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03216975 0,08623592 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03216975 0,08613553 ! catecholamine transport GO:0051937 7 6 0,000 0,03216975 0,08603537 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03216975 0,08593545 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03216975 0,08583576 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03216975 0,08573629 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03216975 0,08563706 ! protein prenylation GO:0018342 10 6 0,000 0,03216975 0,08553806 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03216975 0,08543929 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,03216975 0,08534074 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03216975 0,08524242 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03216975 0,08514433 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03216975 0,08504646 ! regulation of cellular component size GO:0032535 74 52 1,000 0,03249781 0,0858151 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03249781 0,08571669 ! establishment of organelle localization GO:0051656 85 52 1,000 0,03249781 0,0856185 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,03365491 0,08856555 ! kidney development GO:0001822 90 53 1,000 0,03365491 0,08846433 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,03482797 0,09144331 ! DNA catabolic process GO:0006308 67 54 1,000 0,03482797 0,09133904 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,03482797 0,09123501 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,03482797 0,09113121 ! exocytosis GO:0006887 74 55 1,000 0,03601679 0,09413479 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0374309 0,09771971 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0374309 0,09760892 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0374309 0,09749838 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,0374309 0,09738809 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0374309 0,09727804 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0374309 0,09716825 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0374309 0,0970587 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0374309 0,0969494 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0374309 0,09684035 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0374309 0,09673154 ! reproductive behavior GO:0019098 12 7 0,000 0,0374309 0,09662297 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0374309 0,09651465 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0374309 0,09640657 ! oligopeptide transport GO:0006857 11 7 0,000 0,0374309 0,09629873 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0374309 0,09619114 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0374309 0,09608378 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0374309 0,09597666 ! RNA methylation GO:0001510 11 7 0,000 0,0374309 0,09586979 ! pericardium development GO:0060039 8 7 0,000 0,0374309 0,09576315 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0374309 0,09565674 ! fibril organization GO:0043206 13 7 0,000 0,0374309 0,09555057 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0374309 0,09544464 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0374309 0,09533895 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0374309 0,09523348 ! lipoprotein transport GO:0042953 9 7 0,000 0,0374309 0,09512825 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0374309 0,09502325 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0374309 0,09491849 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0374309 0,09481395 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0374309 0,09470965 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0374309 0,09460557 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0374309 0,09450172 ! chemosensory behavior GO:0007635 9 7 0,000 0,0374309 0,0943981 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,0374309 0,09429471 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0374309 0,09419154 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0374309 0,0940886 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0374309 0,09398588 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0374309 0,09388339 ! reflex GO:0060004 12 7 0,000 0,0374309 0,09378112 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0374309 0,09367907 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0374309 0,09357725 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0374309 0,09347564 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0374309 0,09337426 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0374309 0,0932731 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0374309 0,09317215 ! spinal cord patterning GO:0021511 7 7 0,000 0,0374309 0,09307142 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0374309 0,09297092 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,0374309 0,09287062 ! adrenal gland development GO:0030325 17 7 0,000 0,0374309 0,09277055 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0374309 0,09267069 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,0374309 0,09257104 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0374309 0,09247161 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,0374309 0,09237239 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,0374309 0,09227338 ! endosome organization GO:0007032 10 7 0,000 0,0374309 0,09217459 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0374309 0,09207601 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0374309 0,09197764 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0374309 0,09187947 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0374309 0,09178152 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0374309 0,09168378 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0374309 0,09158624 ! galactose metabolic process GO:0006012 10 7 0,000 0,0374309 0,09148891 ! vesicle fusion GO:0006906 15 7 0,000 0,0374309 0,09139179 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0374309 0,09129488 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0374309 0,09119817 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0374309 0,09110166 ! retinol metabolic process GO:0042572 9 7 0,000 0,0374309 0,09100536 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,0374309 0,09090926 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,0374309 0,09081336 ! rRNA modification GO:0000154 12 7 0,000 0,0374309 0,09071767 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0374309 0,09062218 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0374309 0,09052689 ! intermediate filament organization GO:0045109 11 7 0,000 0,0374309 0,09043179 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0374309 0,0903369 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0374309 0,09024221 ! fibrinolysis GO:0042730 9 7 0,000 0,0374309 0,09014772 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,0374309 0,09005342 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0374309 0,08995932 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0374309 0,08986542 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0374309 0,08977171 ! response to tropane GO:0014073 13 7 0,000 0,0374309 0,0896782 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0374309 0,08958488 ! melanosome localization GO:0032400 10 7 0,000 0,0374309 0,08949175 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0374309 0,08939882 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0374309 0,08930609 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0374309 0,08921354 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0374309 0,08912119 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0374309 0,08902903 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0374309 0,08893705 ! mast cell activation GO:0045576 9 7 0,000 0,0374309 0,08884527 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0374309 0,08875368 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,0374309 0,08866227 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0374309 0,08857106 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0374309 0,08848003 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,0374309 0,08838919 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,0374309 0,08829853 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,0374309 0,08820806 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,0374309 0,08811778 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0374309 0,08802768 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0374309 0,08793776 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0374309 0,08784803 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0374309 0,08775848 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0374309 0,08766911 ! neuroblast proliferation GO:0007405 13 7 0,000 0,0374309 0,08757993 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0374309 0,08749092 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0374309 0,0874021 ! diuresis GO:0030146 12 7 0,000 0,0374309 0,08731346 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0374309 0,08722499 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0374309 0,08713671 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0374309 0,0870486 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0374309 0,08696067 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0374309 0,08687292 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0374309 0,08678535 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0374309 0,08669795 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0374309 0,08661073 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0374309 0,08652369 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0374309 0,08643682 ! lymph node development GO:0048535 9 7 0,000 0,0374309 0,08635012 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0374309 0,0862636 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0374309 0,08617725 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0374309 0,08609107 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,0374309 0,08600506 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0374309 0,08591923 ! ATP catabolic process GO:0006200 10 7 0,000 0,0374309 0,08583357 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0374309 0,08574808 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0374309 0,08566275 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0374309 0,0855776 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0374309 0,08549262 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0374309 0,08540781 ! muscle adaptation GO:0043500 12 7 0,000 0,0374309 0,08532316 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0374309 0,08523868 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0374309 0,08515437 ! retina homeostasis GO:0001895 9 7 0,000 0,0374309 0,08507023 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0374309 0,08498625 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0374309 0,08490243 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0374309 0,08481879 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0374309 0,0847353 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0374309 0,08465198 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0374309 0,08456883 ! coenzyme biosynthetic process GO:0009108 67 57 1,000 0,03844089 0,08676549 ! secondary metabolic process GO:0019748 84 57 1,000 0,03844089 0,08668043 ! gonad development GO:0008406 79 57 1,000 0,03844089 0,08659553 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,03967576 0,08928988 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,0409256 0,09201259 ! lung development GO:0030324 94 59 1,000 0,0409256 0,09192274 ! actin filament organization GO:0007015 95 59 1,000 0,0409256 0,09183306 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,0409256 0,09174355 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,0421902 0,09448633 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,0421902 0,09439442 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04266375 0,09536115 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04266375 0,09526857 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04266375 0,09517616 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04266375 0,09508394 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04266375 0,09499189 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04266375 0,09490002 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04266375 0,09480833 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04266375 0,09471682 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04266375 0,09462548 ! phosphate transport GO:0006817 10 8 0,000 0,04266375 0,09453432 ! N-glycan processing GO:0006491 12 8 0,000 0,04266375 0,09444333 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04266375 0,09435252 ! UTP metabolic process GO:0046051 8 8 0,000 0,04266375 0,09426189 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04266375 0,09417142 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04266375 0,09408114 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,04266375 0,09399102 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04266375 0,09390108 ! succinate metabolic process GO:0006105 14 8 0,000 0,04266375 0,0938113 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04266375 0,0937217 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04266375 0,09363228 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,04266375 0,09354302 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04266375 0,09345393 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,04266375 0,09336501 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04266375 0,09327626 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04266375 0,09318768 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04266375 0,09309926 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04266375 0,09301102 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04266375 0,09292294 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04266375 0,09283503 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04266375 0,09274728 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04266375 0,0926597 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04266375 0,09257229 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04266375 0,09248504 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04266375 0,09239795 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04266375 0,09231103 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04266375 0,09222427 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04266375 0,09213768 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04266375 0,09205124 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04266375 0,09196497 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04266375 0,09187886 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,04266375 0,09179291 ! macrophage activation GO:0042116 12 8 0,000 0,04266375 0,09170713 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04266375 0,0916215 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04266375 0,09153603 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04266375 0,09145072 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04266375 0,09136557 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04266375 0,09128058 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04266375 0,09119575 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04266375 0,09111107 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04266375 0,09102655 ! ruffle organization GO:0031529 11 8 0,000 0,04266375 0,09094219 ! osteoblast development GO:0002076 13 8 0,000 0,04266375 0,09085799 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04266375 0,09077394 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04266375 0,09069004 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04266375 0,0906063 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04266375 0,09052272 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04266375 0,09043929 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04266375 0,09035601 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04266375 0,09027288 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04266375 0,09018991 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04266375 0,09010709 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,04266375 0,09002443 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,04266375 0,08994191 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04266375 0,08985955 ! segment specification GO:0007379 10 8 0,000 0,04266375 0,08977733 ! cellular extravasation GO:0045123 11 8 0,000 0,04266375 0,08969527 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04266375 0,08961336 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04266375 0,08953159 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04266375 0,08944998 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04266375 0,08936851 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04266375 0,08928719 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04266375 0,08920602 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04266375 0,089125 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04266375 0,08904412 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04266375 0,08896339 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04266375 0,08888281 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04266375 0,08880238 ! icosanoid secretion GO:0032309 12 8 0,000 0,04266375 0,08872208 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04266375 0,08864194 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04266375 0,08856194 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04266375 0,08848208 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04266375 0,08840236 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04266375 0,08832279 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04266375 0,08824337 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04266375 0,08816408 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04266375 0,08808494 ! sterol catabolic process GO:0016127 9 8 0,000 0,04266375 0,08800594 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04266375 0,08792708 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04266375 0,08784837 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04266375 0,08776979 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04266375 0,08769135 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04266375 0,08761306 ! prophase GO:0051324 11 8 0,000 0,04266375 0,0875349 ! S phase GO:0051320 8 8 0,000 0,04266375 0,08745688 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04266375 0,08737901 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04266375 0,08730127 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04266375 0,08722367 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04266375 0,0871462 ! hormone catabolic process GO:0042447 13 8 0,000 0,04266375 0,08706888 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04266375 0,08699169 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04266375 0,08691464 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04266375 0,08683772 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04266375 0,08676094 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04266375 0,0866843 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04266375 0,08660779 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04266375 0,08653141 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04266375 0,08645518 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04266375 0,08637907 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04266375 0,0863031 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04266375 0,08622726 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04266375 0,08615156 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04266375 0,08607599 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,04266375 0,08600055 ! meiosis GO:0007126 96 61 1,000 0,04346937 0,08754777 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,04346937 0,08747117 ! urogenital system development GO:0001655 101 61 1,000 0,04346937 0,08739471 ! extracellular matrix organization GO:0030198 103 61 1,000 0,04346937 0,08731838 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,04346937 0,08724219 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,04346937 0,08716613 ! meiotic cell cycle GO:0051321 97 62 1,000 0,04476292 0,0896818 ! organelle localization GO:0051640 96 62 1,000 0,04476292 0,08960375 ! respiratory tube development GO:0030323 99 62 1,000 0,04476292 0,08952583 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,04607065 0,09206124 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,04607065 0,09198133 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,04607065 0,09190155 ! regulation of lipase activity GO:0060191 109 63 1,000 0,04607065 0,09182191 ! appendage morphogenesis GO:0035107 93 64 1,000 0,04739238 0,09437443 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,04739238 0,09429279 ! respiratory system development GO:0060541 100 64 1,000 0,04739238 0,09421129 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04786845 0,09507551 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04786845 0,09499347 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04786845 0,09491158 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04786845 0,09482983 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04786845 0,09474822 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04786845 0,09466676 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04786845 0,09458543 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04786845 0,09450424 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04786845 0,09442319 ! GTP metabolic process GO:0046039 9 9 0,000 0,04786845 0,09434228 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04786845 0,0942615 ! social behavior GO:0035176 14 9 0,000 0,04786845 0,09418087 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04786845 0,09410037 ! artery development GO:0060840 19 9 0,000 0,04786845 0,09402001 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04786845 0,09393979 ! response to pain GO:0048265 16 9 0,000 0,04786845 0,09385971 ! protein complex disassembly GO:0043241 17 9 0,000 0,04786845 0,09377976 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04786845 0,09369995 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04786845 0,09362027 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04786845 0,09354073 ! lung alveolus development GO:0048286 17 9 0,000 0,04786845 0,09346132 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04786845 0,09338205 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04786845 0,09330291 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04786845 0,09322391 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04786845 0,09314504 ! protein targeting to ER GO:0045047 19 9 0,000 0,04786845 0,0930663 ! endoderm development GO:0007492 12 9 0,000 0,04786845 0,0929877 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04786845 0,09290923 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04786845 0,09283089 ! arginine catabolic process GO:0006527 10 9 0,000 0,04786845 0,09275268 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04786845 0,09267461 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04786845 0,09259667 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04786845 0,09251885 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04786845 0,09244117 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04786845 0,09236362 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04786845 0,0922862 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04786845 0,09220891 ! mannose metabolic process GO:0006013 9 9 0,000 0,04786845 0,09213175 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04786845 0,09205471 ! receptor clustering GO:0043113 15 9 0,000 0,04786845 0,09197781 ! epithelial cell development GO:0002064 10 9 0,000 0,04786845 0,09190103 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04786845 0,09182438 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04786845 0,09174786 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04786845 0,09167147 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04786845 0,09159521 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04786845 0,09151907 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04786845 0,09144305 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04786845 0,09136717 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04786845 0,09129141 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04786845 0,09121577 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04786845 0,09114026 ! DNA ligation GO:0006266 14 9 0,000 0,04786845 0,09106488 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04786845 0,09098962 ! response to amine stimulus GO:0014075 13 9 0,000 0,04786845 0,09091448 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04786845 0,09083947 ! erythrocyte development GO:0048821 11 9 0,000 0,04786845 0,09076458 ! renal water homeostasis GO:0003091 14 9 0,000 0,04786845 0,09068982 ! postreplication repair GO:0006301 11 9 0,000 0,04786845 0,09061517 ! mRNA cleavage GO:0006379 13 9 0,000 0,04786845 0,09054066 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04786845 0,09046626 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04786845 0,09039198 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04786845 0,09031783 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04786845 0,0902438 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04786845 0,09016989 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04786845 0,0900961 ! acid secretion GO:0046717 14 9 0,000 0,04786845 0,09002243 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04786845 0,08994889 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04786845 0,08987546 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04786845 0,08980215 ! purine base metabolic process GO:0006144 18 9 0,000 0,04786845 0,08972896 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04786845 0,08965589 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04786845 0,08958294 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04786845 0,08951011 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04786845 0,0894374 ! detection of calcium ion GO:0005513 13 9 0,000 0,04786845 0,0893648 ! blastocyst formation GO:0001825 12 9 0,000 0,04786845 0,08929232 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04786845 0,08921996 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04786845 0,08914772 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04786845 0,0890756 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04786845 0,08900359 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04786845 0,08893169 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04786845 0,08885992 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04786845 0,08878826 ! prepulse inhibition GO:0060134 14 9 0,000 0,04786845 0,08871671 ! embryonic placenta development GO:0001892 12 9 0,000 0,04786845 0,08864528 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04786845 0,08857396 ! insulin secretion GO:0030073 17 9 0,000 0,04786845 0,08850276 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04786845 0,08843168 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04786845 0,0883607 ! nucleus localization GO:0051647 15 9 0,000 0,04786845 0,08828984 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04786845 0,0882191 ! reproductive structure development GO:0048608 90 65 1,000 0,04872792 0,08973115 ! regulation of caspase activity GO:0043281 97 65 1,000 0,04872792 0,08965937 ! appendage development GO:0048736 94 65 1,000 0,04872792 0,0895877 GO:0060173|limb development, ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,04872792 0,08951614 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,05007708 0,09192122 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,05007708 0,09184792 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,05007708 0,09177474 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,05143969 0,09419689 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,05143969 0,09412195 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,05281556 0,09656262 ! rhythmic process GO:0048511 105 68 1,000 0,05281556 0,09648592 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05304515 0,09682845 ! neuron fate specification GO:0048665 11 10 0,000 0,05304515 0,09675166 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05304515 0,096675 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05304515 0,09659846 ! thyroid gland development GO:0030878 19 10 0,000 0,05304515 0,09652203 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05304515 0,09644573 ! synapsis GO:0007129 13 10 0,000 0,05304515 0,09636955 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05304515 0,09629349 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05304515 0,09621755 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05304515 0,09614172 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,05304515 0,09606602 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05304515 0,09599044 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05304515 0,09591498 ! androgen metabolic process GO:0008209 13 10 0,000 0,05304515 0,09583963 ! phospholipid efflux GO:0033700 16 10 0,000 0,05304515 0,0957644 ! hippocampus development GO:0021766 19 10 0,000 0,05304515 0,09568929 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05304515 0,0956143 ! blood vessel remodeling GO:0001974 21 10 0,000 0,05304515 0,09553943 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05304515 0,09546467 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05304515 0,09539003 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05304515 0,09531551 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05304515 0,0952411 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05304515 0,09516681 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05304515 0,09509263 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05304515 0,09501857 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05304515 0,09494463 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,05304515 0,0948708 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05304515 0,09479709 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05304515 0,09472349 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05304515 0,09465 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05304515 0,09457663 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05304515 0,09450337 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05304515 0,09443022 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05304515 0,09435719 ! forebrain cell migration GO:0021885 17 10 0,000 0,05304515 0,09428427 ! lipid digestion GO:0044241 15 10 0,000 0,05304515 0,09421147 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05304515 0,09413877 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05304515 0,09406619 ! UV protection GO:0009650 14 10 0,000 0,05304515 0,09399372 ! entry into host cell GO:0030260 20 10 0,000 0,05304515 0,09392136 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05304515 0,09384911 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05304515 0,09377698 ! regulation of bone resorption GO:0045124 24 10 0,000 0,05304515 0,09370495 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05304515 0,09363304 ! regulation of organ growth GO:0046620 11 10 0,000 0,05304515 0,09356123 ! response to dsRNA GO:0043331 18 10 0,000 0,05304515 0,09348954 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05304515 0,09341795 ! embryonic axis specification GO:0000578 12 10 0,000 0,05304515 0,09334648 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05304515 0,09327511 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05304515 0,09320386 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05304515 0,09313271 ! cranial nerve development GO:0021545 12 10 0,000 0,05304515 0,09306167 ! fucose catabolic process GO:0019317 16 10 0,000 0,05304515 0,09299074 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05304515 0,09291992 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05304515 0,0928492 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05304515 0,09277859 ! zymogen activation GO:0031638 14 10 0,000 0,05304515 0,09270809 ! salivary gland development GO:0007431 22 10 0,000 0,05304515 0,0926377 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05304515 0,09256741 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05304515 0,09249723 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05304515 0,09242716 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05304515 0,09235719 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,05304515 0,09228733 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05304515 0,09221757 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05304515 0,09214792 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05304515 0,09207838 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05304515 0,09200894 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05304515 0,0919396 ! detection of bacterium GO:0016045 10 10 0,000 0,05304515 0,09187037 ! embryonic gut development GO:0048566 11 10 0,000 0,05304515 0,09180124 ! activation of innate immune response GO:0002218 10 10 0,000 0,05304515 0,09173222 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05304515 0,0916633 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05304515 0,09159448 ! developmental induction GO:0031128 13 10 0,000 0,05304515 0,09152577 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05304515 0,09145716 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05304515 0,09138865 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05304515 0,09132025 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05304515 0,09125194 ! humoral immune response GO:0006959 86 70 1,000 0,05560634 0,09558639 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,05560634 0,095515 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,05560634 0,09544372 ! regulation of catabolic process GO:0009894 106 70 1,000 0,05560634 0,09537255 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,0570209 0,09772584 ! muscle cell differentiation GO:0042692 104 71 1,000 0,0570209 0,09765307 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,0570209 0,09758042 ! rRNA transcription GO:0009303 17 11 0,000 0,058194 0,09951391 ! respiratory burst GO:0045730 14 11 0,000 0,058194 0,09943997 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,058194 0,09936615 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,058194 0,09929244 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,058194 0,09921883 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,058194 0,09914534 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,058194 0,09907195 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,058194 0,09899867 ! RNA polyadenylation GO:0043631 19 11 0,000 0,058194 0,0989255 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,058194 0,09885244 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,058194 0,09877949 ! mating GO:0007618 14 11 0,000 0,058194 0,09870664 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,058194 0,0986339 ! T cell proliferation GO:0042098 20 11 0,000 0,058194 0,09856127 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,058194 0,09848874 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,058194 0,09841633 ! bone resorption GO:0045453 16 11 0,000 0,058194 0,09834401 ! regulated secretory pathway GO:0045055 14 11 0,000 0,058194 0,09827181 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,058194 0,09819971 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,058194 0,09812772 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,058194 0,09805583 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,058194 0,09798404 ! syncytium formation GO:0006949 15 11 0,000 0,058194 0,09791237 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,058194 0,09784079 ! mitotic spindle organization GO:0007052 15 11 0,000 0,058194 0,09776932 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,058194 0,09769796 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,058194 0,0976267 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,058194 0,09755554 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,058194 0,09748449 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,058194 0,09741354 ! temperature homeostasis GO:0001659 16 11 0,000 0,058194 0,09734269 ! L-glutamate transport GO:0015813 16 11 0,000 0,058194 0,09727195 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,058194 0,09720131 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,058194 0,09713077 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,058194 0,09706034 ! stem cell development GO:0048864 29 11 0,000 0,058194 0,09699 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,058194 0,09691977 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,058194 0,09684964 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,058194 0,09677961 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,058194 0,09670969 ! vasoconstriction GO:0042310 15 11 0,000 0,058194 0,09663986 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,058194 0,09657013 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,058194 0,09650051 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,058194 0,09643098 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,058194 0,09636156 ! ribosome assembly GO:0042255 13 11 0,000 0,058194 0,09629223 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,058194 0,09622301 GO:0006809|nitric oxide biosynthetic process, ! chromatin silencing GO:0006342 19 11 0,000 0,058194 0,09615388 ! nucleosome positioning GO:0016584 13 11 0,000 0,058194 0,09608486 ! regulation of isotype switching GO:0045191 19 11 0,000 0,058194 0,09601593 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,058194 0,0959471 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,058194 0,09587837 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,058194 0,09580974 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,058194 0,0957412 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,058194 0,09567277 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,058194 0,09560443 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,058194 0,09553619 ! male genitalia development GO:0030539 13 11 0,000 0,058194 0,09546805 ! cholesterol efflux GO:0033344 19 11 0,000 0,058194 0,0954 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,058194 0,09533205 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,058194 0,0952642 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,058194 0,09519645 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,058194 0,09512879 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,058194 0,09506122 ! defense response to fungus GO:0050832 12 11 0,000 0,058194 0,09499376 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,058194 0,09492639 ! lysogeny GO:0030069 18 11 0,000 0,058194 0,09485911 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,058194 0,09479193 ! acrosome reaction GO:0007340 13 11 0,000 0,058194 0,09472484 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,058194 0,09465785 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,05844801 0,09500383 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,05844801 0,09493674 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,05844801 0,09486974 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,05988749 0,09713767 ! protein import into nucleus GO:0006606 118 74 1,000 0,06133916 0,09942217 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,06133916 0,09935216 ! blood coagulation GO:0007596 116 75 1,000 0,06280286 0,10165135 GO:0050817|coagulation, ! regulation of ligase activity GO:0051340 114 75 1,000 0,06280286 0,10157986 ! nuclear import GO:0051170 121 75 1,000 0,06280286 0,10150848 ! cofactor biosynthetic process GO:0051188 92 75 1,000 0,06280286 0,1014372 ! lactation GO:0007595 20 12 0,000 0,06331515 0,10219287 ! reproductive cellular process GO:0048610 14 12 0,000 0,06331515 0,10212121 ! tRNA modification GO:0006400 14 12 0,000 0,06331515 0,10204965 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,06331515 0,10197818 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,06331515 0,10190682 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,06331515 0,10183556 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,06331515 0,10176439 ! non-recombinational repair GO:0000726 19 12 0,000 0,06331515 0,10169333 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,06331515 0,10162236 ! peroxisomal transport GO:0043574 21 12 0,000 0,06331515 0,1015515 ! cartilage condensation GO:0001502 18 12 0,000 0,06331515 0,10148073 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,06331515 0,10141006 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,06331515 0,10133949 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,06331515 0,10126902 ! heart looping GO:0001947 15 12 0,000 0,06331515 0,10119864 ! palate development GO:0060021 15 12 0,000 0,06331515 0,10112836 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,06331515 0,10105818 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,06331515 0,1009881 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,06331515 0,10091812 ! arginine metabolic process GO:0006525 13 12 0,000 0,06331515 0,10084823 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,06331515 0,10077844 ! methionine metabolic process GO:0006555 13 12 0,000 0,06331515 0,10070874 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,06331515 0,10063915 ! Golgi organization GO:0007030 18 12 0,000 0,06331515 0,10056964 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,06331515 0,10050024 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,06331515 0,10043093 ! monoamine transport GO:0015844 13 12 0,000 0,06331515 0,10036171 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06331515 0,10029259 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,06331515 0,10022357 ! L-amino acid transport GO:0015807 20 12 0,000 0,06331515 0,10015464 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,06331515 0,1000858 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,06331515 0,10001706 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,06331515 0,09994842 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06331515 0,09987987 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,06331515 0,09981141 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,06331515 0,09974304 ! cerebellum development GO:0021549 13 12 0,000 0,06331515 0,09967477 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,06331515 0,0996066 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,06331515 0,09953851 ! histone methylation GO:0016571 15 12 0,000 0,06331515 0,09947052 ! autonomic nervous system development GO:0048483 23 12 0,000 0,06331515 0,09940262 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,06331515 0,09933482 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,06331515 0,09926711 ! regulation of epidermis development GO:0045682 17 12 0,000 0,06331515 0,09919948 ! intestinal absorption GO:0050892 19 12 0,000 0,06331515 0,09913196 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,06331515 0,09906452 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,06331515 0,09899717 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,06331515 0,09892992 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,06331515 0,09886276 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,06331515 0,09879569 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,06331515 0,09872871 ! microspike assembly GO:0030035 23 12 0,000 0,06331515 0,09866182 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,06331515 0,09859502 ! response to cold GO:0009409 14 12 0,000 0,06331515 0,09852831 ! amine biosynthetic process GO:0009309 97 76 1,000 0,06427841 0,09995966 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,06427841 0,09989212 ! regulation of DNA binding GO:0051101 119 77 1,000 0,06576564 0,10213435 ! sex differentiation GO:0007548 105 77 1,000 0,06576564 0,10206544 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,06576564 0,10199661 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,06576564 0,10192788 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,06576564 0,10185924 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,06840874 0,10588163 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,06840874 0,10581043 ! cGMP metabolic process GO:0046068 16 13 0,000 0,06840874 0,10573932 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,06840874 0,10566831 ! water transport GO:0006833 17 13 0,000 0,06840874 0,10559739 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,06840874 0,10552656 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,06840874 0,10545584 ! lipid localization GO:0010876 24 13 0,000 0,06840874 0,1053852 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,06840874 0,10531466 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,06840874 0,10524422 ! organelle fusion GO:0048284 28 13 0,000 0,06840874 0,10517387 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,06840874 0,10510361 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,06840874 0,10503345 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,06840874 0,10496338 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,06840874 0,1048934 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,06840874 0,10482352 ! response to hexose stimulus GO:0009746 19 13 0,000 0,06840874 0,10475373 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,06840874 0,10468404 ! glutamate metabolic process GO:0006536 18 13 0,000 0,06840874 0,10461443 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,06840874 0,10454492 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,06840874 0,1044755 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,06840874 0,10440618 ! NAD metabolic process GO:0019674 21 13 0,000 0,06840874 0,10433694 ! exocrine system development GO:0035272 27 13 0,000 0,06840874 0,1042678 ! bone mineralization GO:0030282 15 13 0,000 0,06840874 0,10419875 ! regulation of exocytosis GO:0017157 17 13 0,000 0,06840874 0,10412979 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,06840874 0,10406092 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,06840874 0,10399214 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,06840874 0,10392345 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,06840874 0,10385486 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,06840874 0,10378635 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,06840874 0,10371793 ! genitalia development GO:0048806 15 13 0,000 0,06840874 0,10364961 ! tissue regeneration GO:0042246 21 13 0,000 0,06840874 0,10358137 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,06840874 0,10351323 ! cofactor transport GO:0051181 19 13 0,000 0,06840874 0,10344517 ! NADP metabolic process GO:0006739 18 13 0,000 0,06840874 0,10337721 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,06840874 0,10330933 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,06840874 0,10324154 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06840874 0,10317384 ! gas transport GO:0015669 18 13 0,000 0,06840874 0,10310623 ! regulation of RNA stability GO:0043487 28 13 0,000 0,06840874 0,10303871 ! heme biosynthetic process GO:0006783 20 13 0,000 0,06840874 0,10297127 ! regulation of axon extension GO:0030516 23 13 0,000 0,06840874 0,10290393 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,06840874 0,10283667 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,06840874 0,1027695 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,06840874 0,10270242 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,06840874 0,10263543 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,06840874 0,10256852 ! cellular respiration GO:0045333 107 79 1,000 0,0687745 0,10304974 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,07029579 0,10526062 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,07029579 0,10519214 ! forebrain development GO:0030900 131 80 1,000 0,07029579 0,10512375 ! hemostasis GO:0007599 125 81 1,000 0,07182811 0,10734545 ! response to protein stimulus GO:0051789 111 81 1,000 0,07182811 0,10727574 ! regulation of neurological system process GO:0031644 122 81 1,000 0,07182811 0,10720613 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,07182811 0,10713661 GO:0002696|positive regulation of leukocyte activation, ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,07347493 0,10952192 ! superoxide anion generation GO:0042554 18 14 0,000 0,07347493 0,10945099 ! neuron maturation GO:0042551 21 14 0,000 0,07347493 0,10938015 ! regulation of S phase GO:0033261 18 14 0,000 0,07347493 0,1093094 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,07347493 0,10923874 ! myotube differentiation GO:0014902 21 14 0,000 0,07347493 0,10916817 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,07347493 0,1090977 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,07347493 0,10902731 ! inositol metabolic process GO:0006020 20 14 0,000 0,07347493 0,10895701 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,07347493 0,10888681 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,07347493 0,1088167 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,07347493 0,10874667 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,07347493 0,10867674 ! gene silencing by RNA GO:0031047 20 14 0,000 0,07347493 0,1086069 ! limbic system development GO:0021761 25 14 0,000 0,07347493 0,10853714 ! startle response GO:0001964 21 14 0,000 0,07347493 0,10846748 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,07347493 0,1083979 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,07347493 0,10832842 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,07347493 0,10825902 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,07347493 0,10818971 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,07347493 0,10812049 ! glycine metabolic process GO:0006544 22 14 0,000 0,07347493 0,10805136 ! pituitary gland development GO:0021983 23 14 0,000 0,07347493 0,10798232 ! lysosomal transport GO:0007041 20 14 0,000 0,07347493 0,10791337 ! regulation of heart rate GO:0002027 23 14 0,000 0,07347493 0,1078445 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,07347493 0,10777572 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,07347493 0,10770703 ! embryo implantation GO:0007566 27 14 0,000 0,07347493 0,10763843 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,07347493 0,10756991 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,07347493 0,10750148 ! axon cargo transport GO:0008088 27 14 0,000 0,07347493 0,10743314 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,07347493 0,10736489 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,07347493 0,10729672 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,07347493 0,10722864 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07347493 0,10716064 ! mRNA splice site selection GO:0006376 26 14 0,000 0,07347493 0,10709273 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,07347493 0,10702491 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,07347493 0,10695717 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,07347493 0,10688952 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,07347493 0,10682195 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,07347493 0,10675447 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,07347493 0,10668708 ! muscle maintenance GO:0046716 19 14 0,000 0,07347493 0,10661977 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,07347493 0,10655254 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,07347493 0,1064854 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,07347493 0,10641834 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,07347493 0,10635137 ! cell killing GO:0001906 20 14 0,000 0,07347493 0,10628448 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,07347493 0,10621768 ! cilium assembly GO:0042384 20 14 0,000 0,07347493 0,10615096 ! peptide hormone secretion GO:0030072 23 14 0,000 0,07347493 0,10608433 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,07492516 0,10811034 ! transcription initiation GO:0006352 118 85 1,000 0,07806439 0,11256934 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,07806439 0,11249881 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,07806439 0,11242837 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,07851385 0,11300491 ! positive regulation of cell size GO:0045793 20 15 0,000 0,07851385 0,11293424 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,07851385 0,11286366 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,07851385 0,11279316 ! lipid phosphorylation GO:0046834 23 15 0,000 0,07851385 0,11272275 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,07851385 0,11265243 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,07851385 0,1125822 ! bile acid metabolic process GO:0008206 22 15 0,000 0,07851385 0,11251206 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,07851385 0,112442 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,07851385 0,11237203 ! adult walking behavior GO:0007628 25 15 0,000 0,07851385 0,11230215 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,07851385 0,11223235 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,07851385 0,11216264 ! myoblast differentiation GO:0045445 27 15 0,000 0,07851385 0,11209302 ! centrosome cycle GO:0007098 16 15 0,000 0,07851385 0,11202348 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,07851385 0,11195403 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,07851385 0,11188467 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,07851385 0,11181539 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,07851385 0,11174619 ! cerebral cortex development GO:0021987 29 15 0,000 0,07851385 0,11167709 ! response to osmotic stress GO:0006970 22 15 0,000 0,07851385 0,11160807 ! vesicle coating GO:0006901 25 15 0,000 0,07851385 0,11153913 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,07851385 0,11147028 ! DNA integration GO:0015074 22 15 0,000 0,07851385 0,11140151 ! peptide secretion GO:0002790 27 15 0,000 0,07851385 0,11133283 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,07851385 0,11126423 ! regulation of vasodilation GO:0042312 24 15 0,000 0,07851385 0,11119572 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,07851385 0,11112729 ! neuron recognition GO:0008038 22 15 0,000 0,07851385 0,11105895 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,07851385 0,11099069 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,07851385 0,11092251 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,07851385 0,11085442 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,07851385 0,11078641 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,07851385 0,11071849 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,07851385 0,11065064 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,07851385 0,11058288 ! organic cation transport GO:0015695 19 15 0,000 0,07851385 0,11051521 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,07851385 0,11044761 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,07851385 0,1103801 ! peptide hormone processing GO:0016486 19 15 0,000 0,07851385 0,11031268 ! female pregnancy GO:0007565 130 87 1,000 0,08124454 0,11407964 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,08124454 0,11401003 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,08284957 0,11619147 GO:0016054|organic acid catabolic process, ! protein secretion GO:0009306 27 16 0,000 0,08352565 0,11706825 ! hormone secretion GO:0046879 25 16 0,000 0,08352565 0,11699695 ! bone remodeling GO:0046849 24 16 0,000 0,08352565 0,11692575 ! endothelial cell migration GO:0043542 22 16 0,000 0,08352565 0,11685462 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08352565 0,11678359 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,08352565 0,11671264 ! glial cell development GO:0021782 24 16 0,000 0,08352565 0,11664177 ! patterning of blood vessels GO:0001569 24 16 0,000 0,08352565 0,11657099 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,08352565 0,1165003 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,08352565 0,1164297 ! protein polyubiquitination GO:0000209 26 16 0,000 0,08352565 0,11635918 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,08352565 0,11628874 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,08352565 0,11621839 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,08352565 0,11614813 ! fructose metabolic process GO:0006000 20 16 0,000 0,08352565 0,11607795 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,08352565 0,11600785 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,08352565 0,11593784 ! protein export from nucleus GO:0006611 24 16 0,000 0,08352565 0,11586791 ! negative regulation of immune response GO:0050777 28 16 0,000 0,08352565 0,11579807 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,08352565 0,11572831 ! DNA replication initiation GO:0006270 25 16 0,000 0,08352565 0,11565864 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,08352565 0,11558905 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,08352565 0,11551954 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,08352565 0,11545012 ! diencephalon development GO:0021536 25 16 0,000 0,08352565 0,11538078 ! neural crest cell migration GO:0001755 24 16 0,000 0,08352565 0,11531152 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,08352565 0,11524235 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,08352565 0,11517326 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,08352565 0,11510425 ! steroid catabolic process GO:0006706 22 16 0,000 0,08352565 0,11503533 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,08352565 0,11496649 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,08352565 0,11489773 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,08352565 0,11482905 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,08352565 0,11476045 ! sperm-egg recognition GO:0035036 16 16 0,000 0,08352565 0,11469194 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,08352565 0,11462351 ! nerve development GO:0021675 18 16 0,000 0,08352565 0,11455516 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,08352565 0,11448689 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,08352565 0,1144187 ! negative regulation of translation GO:0017148 22 16 0,000 0,08352565 0,11435059 ! regulation of T cell activation GO:0050863 128 89 1,000 0,08446437 0,11556696 ! response to virus GO:0009615 122 91 1,000 0,08772267 0,11995371 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,08851048 0,12095907 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,08851048 0,12088724 ! negative regulation of defense response GO:0031348 19 17 0,000 0,08851048 0,1208155 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,08851048 0,12074384 ! glycerol metabolic process GO:0006071 20 17 0,000 0,08851048 0,12067227 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,08851048 0,12060078 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,08851048 0,12052937 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,08851048 0,12045805 ! signal complex assembly GO:0007172 29 17 0,000 0,08851048 0,12038682 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,08851048 0,12031567 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,08851048 0,1202446 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,08851048 0,12017362 ! memory GO:0007613 25 17 0,000 0,08851048 0,12010272 ! keratinization GO:0031424 17 17 0,000 0,08851048 0,12003191 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,08851048 0,11996117 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,08851048 0,11989052 ! retinoid metabolic process GO:0001523 22 17 0,000 0,08851048 0,11981996 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,08851048 0,11974948 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,08851048 0,11967908 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,08851048 0,11960876 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,08851048 0,11953853 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,08851048 0,11946838 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,08851048 0,11939831 ! membrane budding GO:0006900 29 17 0,000 0,08851048 0,11932832 ! heme metabolic process GO:0042168 27 17 0,000 0,08851048 0,11925841 ! actin filament bundle formation GO:0051017 26 17 0,000 0,08851048 0,11918859 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,08851048 0,11911885 ! body fluid secretion GO:0007589 27 17 0,000 0,08851048 0,11904919 ! stem cell differentiation GO:0048863 36 17 0,000 0,08851048 0,11897961 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,08851048 0,11891011 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,08851048 0,1188407 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,08851048 0,11877136 ! sensory perception of pain GO:0019233 23 17 0,000 0,08851048 0,11870211 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,08851048 0,11863293 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,08851048 0,11856384 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,08851048 0,11849483 ! synaptogenesis GO:0007416 24 17 0,000 0,08851048 0,11842589 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,08851048 0,11835704 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,08851048 0,11828827 ! cell-cell junction organization GO:0045216 25 17 0,000 0,08851048 0,11821958 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,08851048 0,11815096 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,08851048 0,11808243 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,08851048 0,11801398 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,08851048 0,1179456 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,08851048 0,11787731 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,09101826 0,12114698 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,09346849 0,12433633 ! positive regulation of translation GO:0045727 28 18 0,000 0,09346849 0,12426446 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,09346849 0,12419267 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,09346849 0,12412097 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,09346849 0,12404935 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,09346849 0,12397781 ! cAMP metabolic process GO:0046058 33 18 0,000 0,09346849 0,12390635 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,09346849 0,12383497 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,09346849 0,12376368 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,09346849 0,12369247 ! axis specification GO:0009798 26 18 0,000 0,09346849 0,12362134 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,09346849 0,1235503 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,09346849 0,12347933 ! pancreas development GO:0031016 26 18 0,000 0,09346849 0,12340845 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,09346849 0,12333765 ! glutamine metabolic process GO:0006541 23 18 0,000 0,09346849 0,12326692 ! response to retinoic acid GO:0032526 25 18 0,000 0,09346849 0,12319628 ! pigmentation during development GO:0048066 31 18 0,000 0,09346849 0,12312572 ! central nervous system neuron development GO:0021954 30 18 0,000 0,09346849 0,12305525 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,09346849 0,12298485 ! fucose metabolic process GO:0006004 26 18 0,000 0,09346849 0,12291453 ! response to fungus GO:0009620 19 18 0,000 0,09346849 0,12284429 ! peptide cross-linking GO:0018149 31 18 0,000 0,09346849 0,12277414 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,09346849 0,12270406 ! heart process GO:0003015 27 18 0,000 0,09346849 0,12263406 GO:0060047|heart contraction, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,09346849 0,12256415 ! visual learning GO:0008542 35 18 0,000 0,09346849 0,12249431 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,09346849 0,12242455 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,09346849 0,12235488 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,09346849 0,12228528 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,09346849 0,12221576 ! vitamin transport GO:0051180 24 18 0,000 0,09346849 0,12214632 ! hormone transport GO:0009914 27 18 0,000 0,09346849 0,12207695 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,09346849 0,12200767 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,09346849 0,12193847 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,09346849 0,12186934 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,09346849 0,12180029 ! cell-cell recognition GO:0009988 20 18 0,000 0,09346849 0,12173132 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,09346849 0,12166243 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,09346849 0,12159362 ! regulation of glucose import GO:0046324 21 18 0,000 0,09346849 0,12152488 GO:0010827|regulation of glucose transport, ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,0983998 0,12786415 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,0983998 0,12779195 ! positive regulation of ossification GO:0045778 30 19 0,000 0,0983998 0,12771983 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,0983998 0,1276478 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,0983998 0,12757584 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,0983998 0,12750397 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,0983998 0,12743217 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,0983998 0,12736046 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,0983998 0,12728883 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,0983998 0,12721728 ! sensory perception of taste GO:0050909 23 19 0,000 0,0983998 0,12714581 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,0983998 0,12707442 ! smooth muscle contraction GO:0006939 36 19 0,000 0,0983998 0,12700311 ! peroxisome organization GO:0007031 29 19 0,000 0,0983998 0,12693188 ! digestive system process GO:0022600 30 19 0,000 0,0983998 0,12686073 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,0983998 0,12678966 ! response to vitamin A GO:0033189 26 19 0,000 0,0983998 0,12671867 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,0983998 0,12664776 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,0983998 0,12657692 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,0983998 0,12650617 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,0983998 0,1264355 ! plasma membrane fusion GO:0045026 23 19 0,000 0,0983998 0,1263649 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,0983998 0,12629439 ! cytolysis GO:0019835 20 19 0,000 0,0983998 0,12622395 ! vasodilation GO:0042311 33 19 0,000 0,0983998 0,12615359 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,0983998 0,12608331 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,0983998 0,12601311 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,0983998 0,12594298 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,0983998 0,12587294 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,0983998 0,12580297 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,0983998 0,12573308 ! sarcomere organization GO:0045214 23 19 0,000 0,0983998 0,12566327 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,0983998 0,12559353 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,0983998 0,12552387 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,0983998 0,12545429 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,0983998 0,12538479 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,0983998 0,12531536 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,0983998 0,12524601 ! protein stabilization GO:0050821 26 19 0,000 0,0983998 0,12517674 ! protein import GO:0017038 156 99 1,000 0,10111709 0,12856236 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,10111709 0,12849133 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,10282967 0,13059538 ! protein localization in organelle GO:0033365 161 100 1,000 0,10282967 0,13052331 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,10330457 0,13105379 ! iron ion transport GO:0006826 37 20 0,000 0,10330457 0,13098154 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,10330457 0,13090937 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,10330457 0,13083729 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,10330457 0,13076528 ! response to vitamin GO:0033273 29 20 0,000 0,10330457 0,13069335 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,10330457 0,1306215 ! spinal cord development GO:0021510 31 20 0,000 0,10330457 0,13054973 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,10330457 0,13047804 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,10330457 0,13040643 ! chromosome condensation GO:0030261 31 20 0,000 0,10330457 0,1303349 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,10330457 0,13026344 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,10330457 0,13019206 ! pallium development GO:0021543 38 20 0,000 0,10330457 0,13012076 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,10330457 0,13004954 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,10330457 0,1299784 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,10330457 0,12990733 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,10330457 0,12983635 ! collagen catabolic process GO:0030574 25 20 0,000 0,10330457 0,12976544 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,10330457 0,1296946 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,10330457 0,12962385 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,10330457 0,12955317 ! alditol metabolic process GO:0019400 24 20 0,000 0,10330457 0,12948257 ! actin filament-based movement GO:0030048 34 20 0,000 0,10330457 0,12941205 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,10818294 0,13544952 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,10818294 0,13537582 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,10818294 0,13530221 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,10818294 0,13522867 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,10818294 0,13515522 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,10818294 0,13508185 GO:0009799|determination of symmetry, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,10818294 0,13500855 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,10818294 0,13493534 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,10818294 0,1348622 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,10818294 0,13478915 ! phototransduction GO:0007602 25 21 0,000 0,10818294 0,13471617 ! visual behavior GO:0007632 39 21 0,000 0,10818294 0,13464327 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,10818294 0,13457045 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,10818294 0,13449771 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,10818294 0,13442505 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,10818294 0,13435246 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,10818294 0,13427996 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,10818294 0,13420753 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,10818294 0,13413518 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,10818294 0,13406291 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,10818294 0,13399072 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,10818294 0,1339186 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,10818294 0,13384656 ! fatty acid transport GO:0015908 30 21 0,000 0,10818294 0,1337746 ! immunoglobulin production GO:0002377 33 21 0,000 0,10818294 0,13370272 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,10818294 0,13363091 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,10818294 0,13355919 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,10818294 0,13348753 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,10818294 0,13341596 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,10818294 0,13334446 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,10818294 0,13327304 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,10818294 0,13320169 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,10818294 0,13313042 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,10818294 0,13305923 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,10818294 0,13298811 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,10818294 0,13291707 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,11303505 0,13880438 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,11303505 0,13873031 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,11303505 0,13865632 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,11303505 0,13858241 ! leukocyte adhesion GO:0007159 38 22 0,000 0,11303505 0,13850858 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,11303505 0,13843483 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,11303505 0,13836115 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,11303505 0,13828756 ! vasculogenesis GO:0001570 33 22 0,000 0,11303505 0,13821404 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,11303505 0,1381406 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,11303505 0,13806724 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,11303505 0,13799395 ! lysosome organization GO:0007040 37 22 0,000 0,11303505 0,13792075 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,11303505 0,13784762 GO:0051693|actin filament capping, ! regulation of behavior GO:0050795 38 22 0,000 0,11303505 0,13777457 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,11303505 0,13770159 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,11303505 0,1376287 ! membrane depolarization GO:0051899 35 22 0,000 0,11303505 0,13755588 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,11303505 0,13748313 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,11303505 0,13741047 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,11303505 0,13733788 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,11303505 0,13726537 ! blastocyst development GO:0001824 37 22 0,000 0,11303505 0,13719293 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,11303505 0,13712057 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,11786103 0,14289951 ! neuron fate commitment GO:0048663 32 23 0,000 0,11786103 0,14282422 ! embryonic pattern specification GO:0009880 31 23 0,000 0,11786103 0,14274901 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,11786103 0,14267388 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,11786103 0,14259883 ! vesicle targeting GO:0006903 32 23 0,000 0,11786103 0,14252385 ! osteoblast differentiation GO:0001649 40 23 0,000 0,11786103 0,14244896 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,11786103 0,14237414 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,11786103 0,14229941 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,11786103 0,14222475 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,11786103 0,14215017 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,11786103 0,14207566 ! cell fate determination GO:0001709 45 23 0,000 0,11786103 0,14200124 ! pentose metabolic process GO:0019321 31 23 0,000 0,11786103 0,14192689 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,11786103 0,14185263 ! spermatid development GO:0007286 33 23 0,000 0,11786103 0,14177843 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,11786103 0,14170432 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,11786103 0,14163029 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,11786103 0,14155633 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,11786103 0,14148245 ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,11786103 0,14140864 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,11786103 0,14133492 ! regulation of amine transport GO:0051952 38 23 0,000 0,11786103 0,14126126 ! liver development GO:0001889 40 23 0,000 0,11786103 0,14118769 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,12266103 0,1468612 ! initiation of viral infection GO:0019059 42 24 0,000 0,12266103 0,14678479 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,12266103 0,14670846 ! superoxide metabolic process GO:0006801 32 24 0,000 0,12266103 0,14663221 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,12266103 0,14655604 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,12266103 0,14647994 ! fat cell differentiation GO:0045444 37 24 0,000 0,12266103 0,14640393 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,12266103 0,14632799 ! sperm motility GO:0030317 27 24 0,000 0,12266103 0,14625213 ! vacuole organization GO:0007033 39 24 0,000 0,12266103 0,14617636 ! receptor metabolic process GO:0043112 37 24 0,000 0,12266103 0,14610066 ! neural crest cell development GO:0014032 39 24 0,000 0,12266103 0,14602504 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,12266103 0,14594949 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,12266103 0,14587403 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,12266103 0,14579864 ! glutathione metabolic process GO:0006749 29 24 0,000 0,12266103 0,14572333 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,12266103 0,1456481 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,12266103 0,14557295 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,12266103 0,14549787 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,12743518 0,15108295 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,12743518 0,15100511 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,12743518 0,15092736 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,12743518 0,15084968 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,12743518 0,15077208 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,12743518 0,15069456 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,12743518 0,15061712 ! peptide transport GO:0015833 43 25 0,000 0,12743518 0,15053977 ! iron ion homeostasis GO:0055072 39 25 0,000 0,12743518 0,15046249 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,12743518 0,15038529 ! phospholipid transport GO:0015914 35 25 0,000 0,12743518 0,15030817 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,12743518 0,15023112 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,12743518 0,15015416 ! detection of light stimulus GO:0009583 30 25 0,000 0,12743518 0,15007728 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,13218363 0,15558974 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,13218363 0,15551016 ! translational initiation GO:0006413 43 26 0,000 0,13218363 0,15543065 ! circadian rhythm GO:0007623 42 26 0,000 0,13218363 0,15535123 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,13218363 0,15527189 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,13218363 0,15519263 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,13218363 0,15511345 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,13218363 0,15503435 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,13218363 0,15495533 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,13218363 0,15487639 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,13218363 0,15479753 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,13218363 0,15471876 ! regulation of coagulation GO:0050818 39 26 0,000 0,13218363 0,15464006 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,13690651 0,16008387 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,13690651 0,16000253 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,13690651 0,15992127 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,13690651 0,15984009 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,13690651 0,15975899 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,13690651 0,15967798 ! acute-phase response GO:0006953 42 27 0,000 0,13690651 0,15959705 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,13690651 0,1595162 ! myofibril assembly GO:0030239 36 27 0,000 0,13690651 0,15943543 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,13690651 0,15935474 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,13690651 0,15927414 ! natural killer cell activation GO:0030101 35 27 0,000 0,13690651 0,15919362 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,13690651 0,15911318 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,13690651 0,15903282 ! gene silencing GO:0016458 41 27 0,000 0,13690651 0,15895254 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,14160395 0,16432346 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,14160395 0,16424059 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,14160395 0,16415781 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,14160395 0,16407511 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,14160395 0,16399249 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,14160395 0,16390996 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,14160395 0,16382751 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,14160395 0,16374515 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,14160395 0,16366286 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,14160395 0,16358066 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,14160395 0,16349854 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,14160395 0,16341651 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,14160395 0,16333455 ! mesoderm formation GO:0001707 46 28 0,000 0,14160395 0,16325268 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,14160395 0,16317089 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,14160395 0,16308918 ! BMP signaling pathway GO:0030509 40 28 0,000 0,14160395 0,16300755 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,14160395 0,16292601 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,14160395 0,16284455 ! placenta development GO:0001890 37 28 0,000 0,14160395 0,16276317 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1462761 0,16804947 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,1462761 0,16796557 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1462761 0,16788175 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1462761 0,16779802 ! mismatch repair GO:0006298 34 29 0,000 0,1462761 0,16771437 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,1462761 0,16763081 ! muscle cell development GO:0055001 38 29 0,000 0,1462761 0,16754733 ! formation of primary germ layer GO:0001704 48 29 0,000 0,1462761 0,16746393 ! telencephalon development GO:0021537 52 29 0,000 0,1462761 0,16738061 ! eye morphogenesis GO:0048592 51 29 0,000 0,1462761 0,16729738 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1462761 0,16721423 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,15092308 0,17244068 ! organic anion transport GO:0015711 51 30 0,000 0,15092308 0,17235506 ! cholesterol transport GO:0030301 46 30 0,000 0,15092308 0,17226952 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,15092308 0,17218407 ! spliceosome assembly GO:0000245 49 30 0,000 0,15092308 0,1720987 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,15092308 0,17201342 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,15092308 0,17192823 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,15092308 0,17184311 ! ceramide metabolic process GO:0006672 43 30 0,000 0,15092308 0,17175808 ! adult locomotory behavior GO:0008344 47 30 0,000 0,15092308 0,17167314 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,15092308 0,17158828 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,15092308 0,1715035 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,15554503 0,17666843 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,15554503 0,17658123 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,15554503 0,17649412 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,15554503 0,17640709 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,15554503 0,17632015 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,15554503 0,17623329 ! cell fate specification GO:0001708 37 31 0,000 0,15554503 0,17614652 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,15554503 0,17605983 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,15554503 0,17597323 ! RNA modification GO:0009451 40 31 0,000 0,15554503 0,17588671 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,16014209 0,18099597 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,16014209 0,18090708 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,16014209 0,18081826 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,16014209 0,18072954 ! cytokine production GO:0001816 44 32 0,000 0,16014209 0,1806409 ! vesicle localization GO:0051648 47 32 0,000 0,16014209 0,18055236 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,16471438 0,1856164 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,16471438 0,1855255 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,16471438 0,18543469 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,16471438 0,18534397 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,16471438 0,18525334 ! ear morphogenesis GO:0042471 42 33 0,000 0,16471438 0,18516279 ! actomyosin structure organization GO:0031032 43 33 0,000 0,16471438 0,18507234 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,16471438 0,18498197 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,16471438 0,18489169 ! nucleus organization GO:0006997 49 33 0,000 0,16471438 0,1848015 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,16471438 0,1847114 ! lipid homeostasis GO:0055088 55 33 0,000 0,16471438 0,18462138 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,16471438 0,18453146 ! regulation of proteolysis GO:0030162 50 33 0,000 0,16471438 0,18444162 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,16471438 0,18435186 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,16471438 0,1842622 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,16926204 0,18925751 ! mRNA catabolic process GO:0006402 48 34 0,000 0,16926204 0,18916555 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,16926204 0,18907368 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,16926204 0,18898189 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,16926204 0,1888902 ! feeding behavior GO:0007631 45 34 0,000 0,16926204 0,18879859 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,16926204 0,18870708 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,16926204 0,18861565 ! polyol metabolic process GO:0019751 44 34 0,000 0,16926204 0,18852431 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,16926204 0,18843306 ! embryonic organ development GO:0048568 45 34 0,000 0,16926204 0,1883419 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,16926204 0,18825082 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,1737852 0,193188 ! Notch signaling pathway GO:0007219 56 35 0,000 0,1737852 0,19309467 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,1737852 0,19300143 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,1737852 0,19290829 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,1737852 0,19281523 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,1737852 0,19272226 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,1737852 0,19262938 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,1737852 0,19253659 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,1737852 0,19244389 ! protein homooligomerization GO:0051260 52 35 0,000 0,1737852 0,19235128 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,17828399 0,19723578 ! negative regulation of binding GO:0051100 58 36 0,000 0,17828399 0,19714095 ! tissue remodeling GO:0048771 62 36 0,000 0,17828399 0,19704622 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,17828399 0,19695158 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,17828399 0,19685703 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,18275855 0,20170089 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,18275855 0,20160415 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,18275855 0,2015075 ! learning GO:0007612 67 37 0,000 0,18275855 0,20141095 ! ion transmembrane transport GO:0034220 56 37 0,000 0,18275855 0,20131449 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,18275855 0,20121812 ! regulation of protein secretion GO:0050708 51 37 0,000 0,18275855 0,20112184 ! amino acid activation GO:0043038 52 37 0,000 0,18275855 0,20102566 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,18275855 0,20092957 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,18720899 0,20572416 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,18720899 0,20562592 ! phagocytosis GO:0006909 60 38 0,000 0,18720899 0,20552776 ! maintenance of location in cell GO:0051651 69 38 0,000 0,18720899 0,20542971 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,19163544 0,21018671 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,19163544 0,21008652 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,19163544 0,20998643 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,19163544 0,20988644 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,19163544 0,20978654 ! JNK cascade GO:0007254 54 39 0,000 0,19163544 0,20968674 ! cell growth GO:0016049 61 39 0,000 0,19163544 0,20958703 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,19603805 0,21430015 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,19603805 0,21419834 ! regulation of tube size GO:0035150 60 40 0,000 0,19603805 0,21409663 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,19603805 0,21399502 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,19603805 0,21389351 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,19603805 0,21379209 ! peptide metabolic process GO:0006518 56 40 0,000 0,19603805 0,21369076 ! inner ear development GO:0048839 57 40 0,000 0,19603805 0,21358954 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,19603805 0,21348841 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,19603805 0,21338737 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,19603805 0,21328643 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,20041693 0,21794749 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,20041693 0,21784449 ! glucose transport GO:0015758 52 41 0,000 0,20041693 0,21774158 ! endosome transport GO:0016197 71 41 0,000 0,20041693 0,21763878 ! striated muscle contraction GO:0006941 62 41 0,000 0,20041693 0,21753607 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,20041693 0,21743346 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,20041693 0,21733094 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,2047722 0,22194914 ! cellular component disassembly GO:0022411 64 42 0,000 0,2047722 0,22184459 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,2047722 0,22174015 ! hexose transport GO:0008645 54 42 0,000 0,2047722 0,2216358 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,2047722 0,22153155 ! excretion GO:0007588 63 42 0,000 0,2047722 0,2214274 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,2047722 0,22132334 ! leukocyte migration GO:0050900 60 43 0,000 0,20910401 0,22589912 ! neuromuscular process GO:0050905 79 43 0,000 0,20910401 0,22579306 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,20910401 0,2256871 ! tRNA processing GO:0008033 49 43 0,000 0,20910401 0,22558125 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,20910401 0,22547549 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,21341246 0,23001343 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,21341246 0,2299057 ! regulation of ion transport GO:0043269 57 44 0,000 0,21341246 0,22979806 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,21341246 0,22969053 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,21341246 0,2295831 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,21341246 0,22947576 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,21341246 0,22936853 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,21341246 0,2292614 ! RNA catabolic process GO:0006401 64 45 0,000 0,21769769 0,23375569 ! positive regulation of defense response GO:0031349 59 45 0,000 0,21769769 0,23364661 ! regulation of translational initiation GO:0006446 64 45 0,000 0,21769769 0,23353763 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,21769769 0,23342876 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,21769769 0,23331998 ! cell recognition GO:0008037 58 45 0,000 0,21769769 0,23321131 ! cell maturation GO:0048469 60 45 0,000 0,21769769 0,23310274 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,22195982 0,23755588 ! cell redox homeostasis GO:0045454 63 46 0,000 0,22195982 0,23744539 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,22195982 0,237335 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,22619897 0,2417554 ! endocrine system development GO:0035270 83 47 0,000 0,22619897 0,24164311 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,22619897 0,24153093 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,22619897 0,24141885 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,22619897 0,24130688 ! chloride transport GO:0006821 67 48 0,000 0,23041526 0,24569082 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,23041526 0,24557697 ! gastrulation GO:0007369 73 48 0,000 0,23041526 0,24546322 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,23041526 0,24534958 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,23041526 0,24523605 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,23041526 0,24512262 ! regulation of endocytosis GO:0030100 63 48 0,000 0,23041526 0,24500929 ! nuclear export GO:0051168 69 48 0,000 0,23041526 0,24489607 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,23041526 0,24478296 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,23460882 0,24912294 ! sensory perception of smell GO:0007608 61 49 0,000 0,23460882 0,24900798 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,23460882 0,24889312 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,23460882 0,24877837 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,23460882 0,24866373 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,23460882 0,24854919 ! cartilage development GO:0051216 70 49 0,000 0,23460882 0,24843476 ! maintenance of location GO:0051235 84 49 0,000 0,23460882 0,24832043 ! membrane fusion GO:0006944 80 50 0,000 0,23877977 0,25261889 ! proton transport GO:0015992 75 50 0,000 0,23877977 0,25250275 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,23877977 0,25238671 ! hydrogen transport GO:0006818 77 51 0,000 0,24292823 0,25665362 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,24292823 0,25653578 ! adult behavior GO:0030534 80 51 0,000 0,24292823 0,25641805 ! transition metal ion transport GO:0000041 74 52 0,000 0,24705432 0,26065364 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,24705432 0,26053413 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,25115815 0,26474049 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,25115815 0,26461922 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,25115815 0,26449805 ! single fertilization GO:0007338 59 53 0,000 0,25115815 0,264377 ! cell projection assembly GO:0030031 76 53 0,000 0,25115815 0,26425606 ! amino acid transport GO:0006865 84 54 0,000 0,25523985 0,26842783 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,25523985 0,26830515 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,25523985 0,26818258 ! detection of external stimulus GO:0009581 66 54 0,000 0,25523985 0,26806012 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,25523985 0,26793777 ! mesoderm development GO:0007498 76 55 0,000 0,25929954 0,27207525 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,25929954 0,27195118 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,25929954 0,27182723 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,26333733 0,27593433 ! carbohydrate transport GO:0008643 74 57 0,000 0,26735334 0,28001488 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,26735334 0,27988743 ! camera-type eye development GO:0043010 88 57 0,000 0,26735334 0,27976009 ! developmental maturation GO:0021700 75 57 0,000 0,26735334 0,27963287 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,27134768 0,28368167 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,27134768 0,28355278 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,27532047 0,28757361 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,27927183 0,29156842 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,27927183 0,29143613 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,27927183 0,29130395 ! regulation of heart contraction GO:0008016 91 60 0,000 0,27927183 0,2911719 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,27927183 0,29103997 ! fertilization GO:0009566 68 60 0,000 0,27927183 0,29090816 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,28320188 0,29486841 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,28320188 0,29473498 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,28320188 0,29460168 ! amine catabolic process GO:0009310 90 62 0,000 0,28711071 0,29853284 ! neurotransmitter transport GO:0006836 81 62 0,000 0,28711071 0,29839794 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,28711071 0,29826316 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,28711071 0,2981285 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,28711071 0,29799397 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,29099845 0,30189285 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,29486522 0,30576646 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,29486522 0,30562866 ! adaptive immune response GO:0002250 94 64 0,000 0,29486522 0,30549099 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,29871111 0,30933614 ! defense response to bacterium GO:0042742 73 65 0,000 0,29871111 0,30919692 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,29871111 0,30905783 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,29871111 0,30891887 ! activation of immune response GO:0002253 83 65 0,000 0,29871111 0,30878003 ! antigen processing and presentation GO:0019882 96 66 0,000 0,30253625 0,31259361 ! regulation of immune effector process GO:0002697 101 66 0,000 0,30253625 0,31245325 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,30634074 0,31624045 ! acute inflammatory response GO:0002526 92 68 0,000 0,3101247 0,32000306 ! learning or memory GO:0007611 123 68 0,000 0,3101247 0,31985956 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,3101247 0,31971619 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,3101247 0,31957295 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,3101247 0,31942983 ! inorganic anion transport GO:0015698 93 68 0,000 0,3101247 0,31928685 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,31388824 0,32301698 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,31388824 0,32287251 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,31388824 0,32272818 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,31763145 0,32643089 ! eye development GO:0001654 111 70 0,000 0,31763145 0,3262851 ! amine transport GO:0015837 101 70 0,000 0,31763145 0,32613944 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,32135446 0,32981493 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,32135446 0,32966782 ! regulation of blood pressure GO:0008217 107 73 0,000 0,32874028 0,33709436 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,33240331 0,34069858 ! digestion GO:0007586 97 74 0,000 0,33240331 0,34054682 ! tRNA metabolic process GO:0006399 95 76 0,000 0,33967014 0,34783674 ! response to unfolded protein GO:0006986 99 76 0,000 0,33967014 0,34768194 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,34327414 0,35121465 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,34327414 0,35105848 ! protein ubiquitination GO:0016567 125 77 0,000 0,34327414 0,35090246 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,34685868 0,35440914 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,34685868 0,35425176 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,34685868 0,35409453 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,35042387 0,35757537 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,35042387 0,3574168 ! regulation of lyase activity GO:0051339 133 79 0,000 0,35042387 0,35725837 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,35042387 0,35710008 ! chromatin assembly GO:0031497 102 80 0,000 0,35396979 0,36055382 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,35396979 0,36039421 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,35749656 0,36382393 ! mRNA transport GO:0051028 121 81 0,000 0,35749656 0,36366302 ! vitamin metabolic process GO:0006766 103 81 0,000 0,35749656 0,36350225 ! detection of stimulus GO:0051606 108 82 0,000 0,36100428 0,36690669 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,36449305 0,37028888 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 0,000 0,36796297 0,37364893 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,36796297 0,37348404 ! sterol metabolic process GO:0016125 120 84 0,000 0,36796297 0,37331929 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,37141415 0,37665456 ! rRNA metabolic process GO:0016072 107 85 0,000 0,37141415 0,37648856 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,37484667 0,37980059 ! nucleosome organization GO:0034728 114 87 0,000 0,37826065 0,38309093 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,37826065 0,38292231 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,37826065 0,38275385 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,38165618 0,38601988 ! establishment of RNA localization GO:0051236 128 88 0,000 0,38165618 0,3858502 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,38165618 0,38568067 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,38503336 0,38892259 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,38503336 0,38875186 ! RNA localization GO:0006403 135 91 0,000 0,39173306 0,39534271 ! ATP metabolic process GO:0046034 137 91 0,000 0,39173306 0,39516932 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,39505578 0,39834647 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,39505578 0,39817191 ! positive regulation of immune response GO:0050778 121 92 0,000 0,39505578 0,3979975 ! DNA recombination GO:0006310 146 92 0,000 0,39505578 0,39782324 ! sulfur metabolic process GO:0006790 118 92 0,000 0,39505578 0,39764914 ! electron transport chain GO:0022900 123 94 0,000 0,40164742 0,40410721 ! angiogenesis GO:0001525 149 95 0,000 0,40491655 0,40721821 ! carboxylic acid transport GO:0046942 147 95 0,000 0,40491655 0,40704023 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,40816799 0,41012948 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,40816799 0,40995039 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,40816799 0,40977145 ! protein maturation GO:0051604 129 96 0,000 0,40816799 0,40959266 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,41140186 0,41265778 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,41781724 0,41891005 ! regulation of translation GO:0006417 151 100 0,000 0,42099893 0,42191614 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,42099893 0,42173238 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,42099893 0,42154878 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,42099893 0,42136533 ! divalent metal ion transport GO:0070838 171 100 0,000 0,42099893 0,42118205 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,42099893 0,42099893