pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6660-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of cell migration GO:0030335 36 36 6,000 6,336E-11 1,168E-07 ! positive regulation of cell motion GO:0051272 39 39 6,000 1,158E-10 1,067E-07 ! protein amino acid autophosphorylation GO:0046777 28 28 5,000 9,09E-10 5,584E-07 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 5,000 2,163E-09 9,964E-07 ! regulation of cell migration GO:0030334 71 71 6,000 9,188E-09 3,387E-06 ! positive regulation of endothelial cell migration GO:0010595 8 8 3,000 1,519E-08 4,667E-06 ! regulation of locomotion GO:0040012 79 79 6,000 1,96E-08 5,16E-06 ! regulation of cell motion GO:0051270 79 79 6,000 1,96E-08 4,515E-06 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 3,000 2,727E-08 5,585E-06 ! positive regulation of MAP kinase activity GO:0043406 50 49 5,000 3,185E-08 5,869E-06 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 5,000 1,223E-07 2,05E-05 ! regulation of endothelial cell migration GO:0010594 13 13 3,000 1,531E-07 2,351E-05 ! regulation of MAP kinase activity GO:0043405 67 66 5,000 1,974E-07 2,799E-05 ! regulation of protein modification process GO:0031399 79 78 5,000 5,4E-07 7,108E-05 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 2,000 6,005E-07 7,379E-05 ! positive regulation of protein kinase activity GO:0045860 89 86 5,000 9,668E-07 1,114E-04 ! positive regulation of transferase activity GO:0051347 91 88 5,000 1,108E-06 1,201E-04 GO:0033674|positive regulation of kinase activity, ! positive regulation of growth GO:0045927 23 23 3,000 1,843E-06 1,887E-04 ! regulation of intracellular protein transport GO:0033157 25 25 3,000 2,618E-06 2,54E-04 ! negative regulation of blood coagulation GO:0030195 9 8 2,000 3,336E-06 3,074E-04 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 3,000 3,612E-06 3,17E-04 ! regulation of response to external stimulus GO:0032101 65 64 4,000 4,954E-06 4,15E-04 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 2,000 4,99E-06 3,998E-04 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 2,000 4,99E-06 3,832E-04 ! positive regulation of response to external stimulus GO:0032103 30 30 3,000 5,594E-06 4,124E-04 ! regulation of intracellular transport GO:0032386 31 31 3,000 6,405E-06 4,54E-04 ! negative regulation of coagulation GO:0050819 11 10 2,000 7,109E-06 4,852E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 2,000 9,748E-06 6,416E-04 GO:0032388|positive regulation of intracellular transport, ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 9,748E-06 6,195E-04 ! positive regulation of phosphorylation GO:0042327 35 35 3,000 1,054E-05 6,475E-04 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 3,000 1,182E-05 7,029E-04 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of DNA replication GO:0045740 14 13 2,000 1,68E-05 9,678E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 2,000 1,68E-05 9,385E-04 ! positive regulation of locomotion GO:0040017 13 13 2,000 1,68E-05 9,109E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 2,133E-05 1,123E-03 ! regulation of behavior GO:0050795 14 14 2,000 2,133E-05 1,092E-03 ! regulation of blood coagulation GO:0030193 15 14 2,000 2,133E-05 1,062E-03 ! heart development GO:0007507 90 87 4,000 2,251E-05 1,092E-03 ! positive regulation of fibroblast proliferation GO:0048146 15 15 2,000 2,659E-05 1,257E-03 ! insulin receptor signaling pathway GO:0008286 17 15 2,000 2,659E-05 1,225E-03 ! negative regulation of cell activation GO:0050866 15 15 2,000 2,659E-05 1,195E-03 ! cellular response to hormone stimulus GO:0032870 48 46 3,000 3,185E-05 1,398E-03 ! positive regulation of catabolic process GO:0009896 16 16 2,000 3,264E-05 1,399E-03 ! regulation of coagulation GO:0050818 17 16 2,000 3,264E-05 1,367E-03 ! regulation of catabolic process GO:0009894 48 47 3,000 3,472E-05 1,422E-03 ! regulation of fibroblast proliferation GO:0048145 17 17 2,000 3,952E-05 1,583E-03 ! tissue remodeling GO:0048771 17 17 2,000 3,952E-05 1,55E-03 ! regulation of oxidoreductase activity GO:0051341 17 17 2,000 3,952E-05 1,517E-03 ! response to hormone stimulus GO:0009725 102 100 4,000 4,422E-05 1,663E-03 ! regulation of endothelial cell proliferation GO:0001936 19 19 2,000 5,601E-05 2,065E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 2,000 5,601E-05 2,024E-03 ! response to hypoxia GO:0001666 53 53 3,000 5,605E-05 1,986E-03 ! regulation of protein transport GO:0051223 53 53 3,000 5,605E-05 1,949E-03 GO:0070201|regulation of establishment of protein localization, ! response to oxygen levels GO:0070482 55 54 3,000 6,036E-05 2,06E-03 ! negative regulation of multicellular organismal process GO:0051241 55 54 3,000 6,036E-05 2,023E-03 ! peptidyl-tyrosine modification GO:0018212 21 20 2,000 6,572E-05 2,163E-03 ! regulation of protein localization GO:0032880 58 57 3,000 7,477E-05 2,417E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 2,000 7,646E-05 2,43E-03 ! cellular response to insulin stimulus GO:0032869 23 21 2,000 7,646E-05 2,388E-03 ! negative regulation of protein transport GO:0051224 21 21 2,000 7,646E-05 2,349E-03 ! peptidyl-amino acid modification GO:0018193 61 59 3,000 8,566E-05 2,588E-03 ! positive regulation of DNA metabolic process GO:0051054 23 22 2,000 8,829E-05 2,625E-03 ! positive regulation of protein metabolic process GO:0051247 64 64 3,000 1,179E-04 3,45E-03 ! regulation of gene-specific transcription GO:0032583 25 25 2,000 1,308E-04 3,766E-03 ! heart morphogenesis GO:0003007 25 25 2,000 1,308E-04 3,708E-03 ! response to insulin stimulus GO:0032868 28 26 2,000 1,474E-04 4,117E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 1,000 1,585E-04 4,361E-03 ! positive regulation of glucose metabolic process GO:0010907 5 5 1,000 1,585E-04 4,297E-03 ! mRNA stabilization GO:0048255 5 5 1,000 1,585E-04 4,234E-03 GO:0043489|RNA stabilization, ! 2-oxoglutarate metabolic process GO:0006103 5 5 1,000 1,585E-04 4,174E-03 ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 1,585E-04 4,115E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 1,000 1,585E-04 4,058E-03 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 1,000 1,585E-04 4,002E-03 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! muscle cell migration GO:0014812 5 5 1,000 1,585E-04 3,948E-03 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 1,585E-04 3,896E-03 ! receptor clustering GO:0043113 5 5 1,000 1,585E-04 3,844E-03 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 1,585E-04 3,795E-03 ! corticosteroid receptor signaling pathway GO:0031958 5 5 1,000 1,585E-04 3,746E-03 GO:0042921|glucocorticoid receptor signaling pathway, ! protein heterooligomerization GO:0051291 5 5 1,000 1,585E-04 3,698E-03 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 1,000 1,585E-04 3,652E-03 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 1,000 1,585E-04 3,607E-03 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 1,000 1,585E-04 3,563E-03 ! muscle adaptation GO:0043500 5 5 1,000 1,585E-04 3,52E-03 ! cardiac cell differentiation GO:0035051 6 5 1,000 1,585E-04 3,478E-03 ! regulation of epithelial cell proliferation GO:0050678 29 29 2,000 2,055E-04 4,456E-03 ! positive regulation of protein transport GO:0051222 29 29 2,000 2,055E-04 4,405E-03 ! activation of phospholipase C activity GO:0007202 30 30 2,000 2,278E-04 4,825E-03 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 2,000 2,278E-04 4,77E-03 ! vascular process in circulatory system GO:0003018 31 30 2,000 2,278E-04 4,716E-03 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 1,000 2,372E-04 4,857E-03 ! virus-host interaction GO:0019048 6 6 1,000 2,372E-04 4,804E-03 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 2,372E-04 4,752E-03 GO:0050927|positive regulation of positive chemotaxis, ! succinate metabolic process GO:0006105 7 6 1,000 2,372E-04 4,701E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 1,000 2,372E-04 4,651E-03 ! positive regulation of cell growth GO:0030307 6 6 1,000 2,372E-04 4,602E-03 ! ER overload response GO:0006983 6 6 1,000 2,372E-04 4,554E-03 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 2,372E-04 4,507E-03 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 2,372E-04 4,461E-03 ! peptidyl-serine phosphorylation GO:0018105 6 6 1,000 2,372E-04 4,416E-03 ! regulation of bone resorption GO:0045124 6 6 1,000 2,372E-04 4,372E-03 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 2,372E-04 4,328E-03 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 1,000 2,372E-04 4,286E-03 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 2,372E-04 4,244E-03 ! nitric oxide mediated signal transduction GO:0007263 6 6 1,000 2,372E-04 4,203E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 1,000 2,372E-04 4,163E-03 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! regulation of embryonic development GO:0045995 6 6 1,000 2,372E-04 4,124E-03 ! localization within membrane GO:0051668 6 6 1,000 2,372E-04 4,086E-03 ! positive regulation of phospholipase activity GO:0010518 31 31 2,000 2,515E-04 4,291E-03 ! regulation of DNA replication GO:0006275 32 31 2,000 2,515E-04 4,252E-03 ! positive regulation of protein kinase cascade GO:0010740 79 78 3,000 2,546E-04 4,266E-03 ! regulation of phospholipase activity GO:0010517 32 32 2,000 2,767E-04 4,595E-03 ! positive regulation of lipase activity GO:0060193 32 32 2,000 2,767E-04 4,554E-03 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 1,000 3,312E-04 5,403E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 1,000 3,312E-04 5,355E-03 ! positive regulation of cellular catabolic process GO:0031331 7 7 1,000 3,312E-04 5,309E-03 ! oxaloacetate metabolic process GO:0006107 7 7 1,000 3,312E-04 5,263E-03 ! keratinocyte proliferation GO:0043616 7 7 1,000 3,312E-04 5,218E-03 ! negative regulation of lipid metabolic process GO:0045833 7 7 1,000 3,312E-04 5,174E-03 ! regulation of mRNA processing GO:0050684 7 7 1,000 3,312E-04 5,13E-03 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 3,312E-04 5,087E-03 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 1,000 3,312E-04 5,045E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! axon cargo transport GO:0008088 7 7 1,000 3,312E-04 5,004E-03 ! induction of an organ GO:0001759 7 7 1,000 3,312E-04 4,963E-03 ! regulation of mRNA stability GO:0043488 7 7 1,000 3,312E-04 4,923E-03 ! negative regulation of T cell activation GO:0050868 7 7 1,000 3,312E-04 4,884E-03 ! regulation of protein catabolic process GO:0042176 35 34 2,000 3,32E-04 4,857E-03 ! response to peptide hormone stimulus GO:0043434 36 34 2,000 3,32E-04 4,819E-03 ! regulation of cellular localization GO:0060341 86 85 3,000 3,544E-04 5,103E-03 ! positive regulation of response to stimulus GO:0048584 86 85 3,000 3,544E-04 5,063E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 2,000 3,622E-04 5,135E-03 ! integrin-mediated signaling pathway GO:0007229 36 36 2,000 3,94E-04 5,544E-03 ! regulation of lipase activity GO:0060191 36 36 2,000 3,94E-04 5,502E-03 ! regulation of transcription factor activity GO:0051090 38 37 2,000 4,276E-04 5,926E-03 GO:0090046|regulation of transcription regulator activity, ! lung development GO:0030324 38 37 2,000 4,276E-04 5,882E-03 ! negative regulation of bone remodeling GO:0046851 8 8 1,000 4,405E-04 6,014E-03 ! phosphagen metabolic process GO:0006599 8 8 1,000 4,405E-04 5,97E-03 GO:0006600|creatine metabolic process, ! sex determination GO:0007530 8 8 1,000 4,405E-04 5,927E-03 ! peptidyl-serine modification GO:0018209 8 8 1,000 4,405E-04 5,884E-03 ! positive regulation of leukocyte migration GO:0002687 8 8 1,000 4,405E-04 5,841E-03 ! branched chain family amino acid metabolic process GO:0009081 8 8 1,000 4,405E-04 5,8E-03 ! regulation of RNA stability GO:0043487 8 8 1,000 4,405E-04 5,758E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 1,000 4,405E-04 5,718E-03 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 4,405E-04 5,678E-03 ! developmental induction GO:0031128 8 8 1,000 4,405E-04 5,638E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 8 8 1,000 4,405E-04 5,6E-03 ! regulation of homeostatic process GO:0032844 38 38 2,000 4,63E-04 5,845E-03 ! positive regulation of protein modification process GO:0031401 39 39 2,000 5,002E-04 6,272E-03 ! activation of MAPK activity GO:0000187 39 39 2,000 5,002E-04 6,229E-03 ! respiratory tube development GO:0030323 40 39 2,000 5,002E-04 6,188E-03 ! respiratory system development GO:0060541 40 39 2,000 5,002E-04 6,146E-03 ! regulation of response to stress GO:0080134 97 94 3,000 5,205E-04 6,352E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 2,000 5,393E-04 6,539E-03 ! positive regulation of cell size GO:0045793 9 9 1,000 5,65E-04 6,806E-03 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 5,65E-04 6,762E-03 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 1,000 5,65E-04 6,718E-03 ! substrate-bound cell migration GO:0006929 9 9 1,000 5,65E-04 6,675E-03 ! negative regulation of caspase activity GO:0043154 9 9 1,000 5,65E-04 6,632E-03 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 1,000 5,65E-04 6,59E-03 ! positive regulation of protein import into nucleus GO:0042307 9 9 1,000 5,65E-04 6,549E-03 ! positive regulation of oxidoreductase activity GO:0051353 9 9 1,000 5,65E-04 6,508E-03 ! negative regulation of tissue remodeling GO:0034104 9 9 1,000 5,65E-04 6,468E-03 ! regulation of leukocyte migration GO:0002685 9 9 1,000 5,65E-04 6,428E-03 ! estrogen receptor signaling pathway GO:0030520 9 9 1,000 5,65E-04 6,388E-03 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 2,000 6,682E-04 7,509E-03 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 7,045E-04 7,869E-03 ! regulation of glucose metabolic process GO:0010906 10 10 1,000 7,045E-04 7,821E-03 ! regulation of lipid biosynthetic process GO:0046890 10 10 1,000 7,045E-04 7,774E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 1,000 7,045E-04 7,728E-03 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 7,045E-04 7,682E-03 ! neuromuscular junction development GO:0007528 10 10 1,000 7,045E-04 7,637E-03 ! intermediate filament cytoskeleton organization GO:0045104 10 10 1,000 7,045E-04 7,593E-03 ! negative regulation of homeostatic process GO:0032845 10 10 1,000 7,045E-04 7,548E-03 ! protein stabilization GO:0050821 10 10 1,000 7,045E-04 7,505E-03 ! regulation of DNA binding GO:0051101 47 45 2,000 7,641E-04 8,094E-03 ! phosphoinositide-mediated signaling GO:0048015 45 45 2,000 7,641E-04 8,047E-03 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 2,000 8,152E-04 8,537E-03 ! microtubule-based transport GO:0010970 11 11 1,000 8,588E-04 8,943E-03 ! intermediate filament-based process GO:0045103 11 11 1,000 8,588E-04 8,892E-03 ! interaction with host GO:0051701 11 11 1,000 8,588E-04 8,843E-03 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 8,588E-04 8,794E-03 ! endocrine process GO:0050886 11 11 1,000 8,588E-04 8,745E-03 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 8,588E-04 8,697E-03 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 1,000 8,588E-04 8,649E-03 ! skin development GO:0043588 11 11 1,000 8,588E-04 8,602E-03 ! signal complex assembly GO:0007172 11 11 1,000 8,588E-04 8,556E-03 ! protein amino acid methylation GO:0006479 11 11 1,000 8,588E-04 8,51E-03 GO:0008213|protein amino acid alkylation, ! cardiac muscle tissue morphogenesis GO:0055008 11 11 1,000 8,588E-04 8,464E-03 GO:0060415|muscle tissue morphogenesis, ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 1,000 8,588E-04 8,419E-03 GO:0006109|regulation of carbohydrate metabolic process, ! cell cycle arrest GO:0007050 49 49 2,000 9,814E-04 9,57E-03 ! positive regulation of protein catabolic process GO:0045732 12 12 1,000 1,028E-03 9,972E-03 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 1,000 1,028E-03 9,92E-03 ! negative regulation of peptidase activity GO:0010466 12 12 1,000 1,028E-03 9,868E-03 ! renal system process GO:0003014 12 12 1,000 1,028E-03 9,817E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 1,000 1,028E-03 9,766E-03 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 1,028E-03 9,716E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 1,000 1,028E-03 9,667E-03 ! regulation of DNA metabolic process GO:0051052 51 50 2,000 1,041E-03 9,741E-03 ! negative regulation of transport GO:0051051 51 50 2,000 1,041E-03 9,692E-03 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 1,212E-03 0,01122362 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 1,000 1,212E-03 0,0111675 ! vasculogenesis GO:0001570 13 13 1,000 1,212E-03 0,01111195 ! receptor metabolic process GO:0043112 14 13 1,000 1,212E-03 0,01105694 ! negative regulation of protein catabolic process GO:0042177 13 13 1,000 1,212E-03 0,01100247 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 1,212E-03 0,01094853 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 1,000 1,212E-03 0,01089513 ! negative regulation of intracellular transport GO:0032387 13 13 1,000 1,212E-03 0,01084224 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 1,212E-03 0,01078986 ! tissue homeostasis GO:0001894 13 13 1,000 1,212E-03 0,01073799 GO:0048871|multicellular organismal homeostasis, ! protein tetramerization GO:0051262 13 13 1,000 1,212E-03 0,01068661 ! response to retinoic acid GO:0032526 14 14 1,000 1,41E-03 0,01237714 GO:0033189|response to vitamin A, ! regulation of vasoconstriction GO:0019229 14 14 1,000 1,41E-03 0,01231848 ! positive regulation of inflammatory response GO:0050729 14 14 1,000 1,41E-03 0,01226037 ! regulation of binding GO:0051098 60 57 2,000 1,525E-03 0,01319558 ! response to vitamin GO:0033273 15 15 1,000 1,623E-03 0,01397915 ! regulation of transcription factor import into nucleus GO:0042990 15 15 1,000 1,623E-03 0,01391413 ! striated muscle cell differentiation GO:0051146 16 15 1,000 1,623E-03 0,01384971 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 1,623E-03 0,01378589 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 1,623E-03 0,01372265 GO:0090048|negative regulation of transcription regulator activity, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 1,000 1,85E-03 0,01557218 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 1,85E-03 0,0155014 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of systemic arterial blood pressure GO:0003073 17 16 1,000 1,85E-03 0,01543125 ! cell fate specification GO:0001708 16 16 1,000 1,85E-03 0,01536174 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 1,000 1,85E-03 0,01529286 ! positive regulation of cellular protein metabolic process GO:0032270 61 61 2,000 1,856E-03 0,01526665 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 1,000 2,092E-03 0,01713468 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 1,000 2,092E-03 0,01705886 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 2,092E-03 0,01698371 ! myelination GO:0042552 17 17 1,000 2,092E-03 0,01690922 ! dicarboxylic acid metabolic process GO:0043648 18 17 1,000 2,092E-03 0,01683538 ! glucose transport GO:0015758 17 17 1,000 2,092E-03 0,01676219 ! regulation of cellular catabolic process GO:0031329 18 18 1,000 2,347E-03 0,01872866 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 1,000 2,347E-03 0,01864793 ! hexose transport GO:0008645 18 18 1,000 2,347E-03 0,0185679 GO:0015749|monosaccharide transport, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 2,347E-03 0,01848855 ! negative regulation of DNA binding GO:0043392 19 18 1,000 2,347E-03 0,01840987 ! ensheathment of neurons GO:0007272 18 18 1,000 2,347E-03 0,01833186 GO:0008366|axon ensheathment, ! regulation of microtubule-based process GO:0032886 18 18 1,000 2,347E-03 0,01825451 ! negative regulation of catabolic process GO:0009895 18 18 1,000 2,347E-03 0,01817781 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 2,347E-03 0,01810176 ! striated muscle tissue development GO:0014706 69 67 2,000 2,43E-03 0,01865933 ! regulation of cell size GO:0008361 68 68 2,000 2,535E-03 0,01938678 ! regulation of JAK-STAT cascade GO:0046425 19 19 1,000 2,617E-03 0,01993039 ! multicellular organismal metabolic process GO:0044236 19 19 1,000 2,617E-03 0,01984837 ! peripheral nervous system development GO:0007422 19 19 1,000 2,617E-03 0,01976702 ! regulation of protein stability GO:0031647 19 19 1,000 2,617E-03 0,01968634 ! regulation of cell shape GO:0008360 21 19 1,000 2,617E-03 0,01960632 ! positive regulation of transport GO:0051050 71 70 2,000 2,754E-03 0,02054915 ! wound healing GO:0042060 74 70 2,000 2,754E-03 0,02046629 ! muscle tissue development GO:0060537 72 70 2,000 2,754E-03 0,0203841 ! regulation of cell activation GO:0050865 71 71 2,000 2,868E-03 0,02114075 ! negative regulation of binding GO:0051100 21 20 1,000 2,9E-03 0,02129722 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 1,000 2,9E-03 0,02121271 ! positive regulation of hydrolase activity GO:0051345 72 72 2,000 2,984E-03 0,02173919 ! regulation of action potential in neuron GO:0019228 21 21 1,000 3,198E-03 0,02320261 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 3,198E-03 0,02311162 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 3,198E-03 0,02302134 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 1,000 3,198E-03 0,02293177 ! mammary gland development GO:0030879 23 21 1,000 3,198E-03 0,02284288 ! receptor-mediated endocytosis GO:0006898 21 21 1,000 3,198E-03 0,02275469 ! regulation of protein import into nucleus GO:0042306 21 21 1,000 3,198E-03 0,02266717 ! positive regulation of multicellular organismal process GO:0051240 76 76 2,000 3,48E-03 0,02457098 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 3,509E-03 0,02468144 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 22 22 1,000 3,509E-03 0,0245876 ! maintenance of protein location in cell GO:0032507 23 22 1,000 3,509E-03 0,02449446 ! biopolymer methylation GO:0043414 22 22 1,000 3,509E-03 0,02440203 GO:0032259|methylation, ! microtubule-based movement GO:0007018 82 78 2,000 3,745E-03 0,02594867 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 1,000 3,833E-03 0,02645927 ! calcium-mediated signaling GO:0019722 23 23 1,000 3,833E-03 0,02636054 ! cell projection assembly GO:0030031 25 23 1,000 3,833E-03 0,02626255 ! MAPKKK cascade GO:0000165 82 81 2,000 4,166E-03 0,02843798 ! tube development GO:0035295 83 81 2,000 4,166E-03 0,02833305 ! regulation of action potential GO:0001508 24 24 1,000 4,171E-03 0,02826297 ! glucose homeostasis GO:0042593 24 24 1,000 4,171E-03 0,02815944 GO:0033500|carbohydrate homeostasis, ! maintenance of protein location GO:0045185 25 24 1,000 4,171E-03 0,02805667 ! glucan metabolic process GO:0044042 25 24 1,000 4,171E-03 0,02795464 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! blood vessel morphogenesis GO:0048514 84 83 2,000 4,462E-03 0,02979687 ! endosome transport GO:0016197 25 25 1,000 4,523E-03 0,03009042 ! regulation of T cell proliferation GO:0042129 25 25 1,000 4,523E-03 0,02998218 ! positive regulation of DNA binding GO:0043388 26 25 1,000 4,523E-03 0,02987472 ! negative regulation of immune system process GO:0002683 25 25 1,000 4,523E-03 0,02976802 ! JAK-STAT cascade GO:0007259 26 25 1,000 4,523E-03 0,02966209 ! positive regulation of cytokine production GO:0001819 25 25 1,000 4,523E-03 0,0295569 ! positive regulation of binding GO:0051099 27 26 1,000 4,887E-03 0,03182681 ! positive regulation of defense response GO:0031349 26 26 1,000 4,887E-03 0,03171475 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 1,000 4,887E-03 0,03160347 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 4,887E-03 0,03149297 ! negative regulation of cell migration GO:0030336 26 26 1,000 4,887E-03 0,03138324 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 4,887E-03 0,03127427 ! regulation of T cell differentiation GO:0045580 26 26 1,000 4,887E-03 0,03116605 ! regulation of blood vessel size GO:0050880 27 26 1,000 4,887E-03 0,03105858 GO:0035150|regulation of tube size, ! maintenance of location in cell GO:0051651 27 26 1,000 4,887E-03 0,03095185 ! synapse organization GO:0050808 26 26 1,000 4,887E-03 0,03084585 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 2,000 4,93E-03 0,03100958 ! energy reserve metabolic process GO:0006112 28 27 1,000 5,265E-03 0,03300393 ! cAMP-mediated signaling GO:0019933 27 27 1,000 5,265E-03 0,03289206 ! cell growth GO:0016049 27 27 1,000 5,265E-03 0,03278094 ! carbohydrate transport GO:0008643 28 28 1,000 5,656E-03 0,03509548 ! keratinocyte differentiation GO:0030216 28 28 1,000 5,656E-03 0,03497771 ! regulation of mast cell proliferation GO:0070666 28 28 1,000 5,656E-03 0,03486073 ! positive regulation of cell cycle GO:0045787 29 29 1,000 6,059E-03 0,03722466 ! viral reproductive process GO:0022415 29 29 1,000 6,059E-03 0,03710099 ! regulation of lymphocyte proliferation GO:0050670 29 29 1,000 6,059E-03 0,03697814 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! regulation of gene expression, epigenetic GO:0040029 29 29 1,000 6,059E-03 0,0368561 ! response to UV GO:0009411 29 29 1,000 6,059E-03 0,03673487 ! blood vessel development GO:0001568 95 94 2,000 6,319E-03 0,03818045 ! regulation of inflammatory response GO:0050727 30 30 1,000 6,476E-03 0,03900356 ! regulation of cell growth GO:0001558 97 96 2,000 6,699E-03 0,04021345 ! vasculature development GO:0001944 97 96 2,000 6,699E-03 0,04008289 ! skeletal muscle fiber development GO:0048741 31 31 1,000 6,905E-03 0,04118523 ! epidermal cell differentiation GO:0009913 31 31 1,000 6,905E-03 0,04105238 ! negative regulation of cell motion GO:0051271 31 31 1,000 6,905E-03 0,04092037 ! endocytosis GO:0006897 99 98 2,000 7,092E-03 0,04189351 GO:0010324|membrane invagination, ! posttranscriptional regulation of gene expression GO:0010608 98 98 2,000 7,092E-03 0,04175966 ! blood circulation GO:0008015 99 98 2,000 7,092E-03 0,04162667 GO:0003013|circulatory system process, ! cell redox homeostasis GO:0045454 32 32 1,000 7,347E-03 0,0429862 ! muscle fiber development GO:0048747 32 32 1,000 7,347E-03 0,04285016 ! regulation of lymphocyte differentiation GO:0045619 32 32 1,000 7,347E-03 0,04271499 ! kidney development GO:0001822 32 32 1,000 7,347E-03 0,04258067 ! maintenance of location GO:0051235 33 32 1,000 7,347E-03 0,04244718 ! muscle organ development GO:0007517 102 100 2,000 7,499E-03 0,04319059 ! activation of protein kinase activity GO:0032147 35 33 1,000 7,801E-03 0,04479173 ! regulation of angiogenesis GO:0045765 35 34 1,000 8,268E-03 0,04732464 ! regulation of bone remodeling GO:0046850 34 34 1,000 8,268E-03 0,04717812 ! muscle cell differentiation GO:0042692 35 34 1,000 8,268E-03 0,04703251 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 8,268E-03 0,0468878 ! regulation of lipid metabolic process GO:0019216 34 34 1,000 8,268E-03 0,04674397 ! viral reproduction GO:0016032 34 34 1,000 8,268E-03 0,04660102 ! regulation of cell morphogenesis GO:0022604 38 35 1,000 8,747E-03 0,0491513 ! regulation of tissue remodeling GO:0034103 35 35 1,000 8,747E-03 0,04900191 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 9,239E-03 0,0515977 ! coagulation GO:0050817 39 36 1,000 9,239E-03 0,05144181 GO:0007596|blood coagulation, ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 9,742E-03 0,0540819 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! negative regulation of protein kinase activity GO:0006469 37 37 1,000 9,742E-03 0,05391949 ! DNA damage response, signal transduction GO:0042770 37 37 1,000 9,742E-03 0,05375805 ! adaptive immune response GO:0002250 37 37 1,000 9,742E-03 0,05359758 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of kinase activity GO:0033673 38 38 1,000 0,01025789 0,05626575 ! cell-matrix adhesion GO:0007160 39 38 1,000 0,01025789 0,05609879 ! urogenital system development GO:0001655 38 38 1,000 0,01025789 0,05593282 ! axon guidance GO:0007411 39 38 1,000 0,01025789 0,05576782 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 0,01025789 0,0556038 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,01078533 0,05829139 ! hemostasis GO:0007599 42 39 1,000 0,01078533 0,05812095 ! protein oligomerization GO:0051259 39 39 1,000 0,01078533 0,0579515 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,01132459 0,06067217 ! negative regulation of transferase activity GO:0051348 40 40 1,000 0,01132459 0,06049631 ! myeloid cell differentiation GO:0030099 42 40 1,000 0,01132459 0,06032146 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,01187558 0,06307405 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of caspase activity GO:0043281 41 41 1,000 0,01187558 0,0628928 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,0124382 0,06568366 ! regulation of endopeptidase activity GO:0052548 42 42 1,000 0,0124382 0,06549599 ! cell-substrate adhesion GO:0031589 43 42 1,000 0,0124382 0,06530939 ! protein ubiquitination GO:0016567 43 42 1,000 0,0124382 0,06512385 ! one-carbon metabolic process GO:0006730 42 42 1,000 0,0124382 0,06493937 ! mitochondrion organization GO:0007005 44 43 1,000 0,01301234 0,06774505 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,01301234 0,06755422 ! vitamin metabolic process GO:0006766 44 44 1,000 0,01359792 0,07039599 ! Wnt receptor signaling pathway GO:0016055 46 45 1,000 0,01419484 0,07328039 ! regulation of peptidase activity GO:0052547 46 46 1,000 0,01480301 0,07620655 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 1,000 0,01480301 0,07599428 ! regulation of membrane potential GO:0042391 46 46 1,000 0,01480301 0,07578318 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 1,000 0,01542232 0,07873502 ! regulation of blood pressure GO:0008217 48 47 1,000 0,01542232 0,07851752 ! actin filament organization GO:0007015 50 48 1,000 0,01605269 0,08150169 ! DNA recombination GO:0006310 48 48 1,000 0,01605269 0,08127778 ! ossification GO:0001503 50 49 1,000 0,01669402 0,08429339 GO:0060348|bone development, ! gland development GO:0048732 51 49 1,000 0,01669402 0,08406308 ! skeletal muscle tissue development GO:0007519 50 49 1,000 0,01669402 0,08383402 GO:0060538|skeletal muscle organ development, ! response to nutrient GO:0007584 49 49 1,000 0,01669402 0,08360621 ! regulation of defense response GO:0031347 50 50 1,000 0,01734622 0,08663711 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 1,000 0,01734622 0,08640295 ! transcription initiation GO:0006352 50 50 1,000 0,01734622 0,08617006 ! anatomical structure homeostasis GO:0060249 51 50 1,000 0,01734622 0,08593842 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,0180092 0,08898381 ! interphase of mitotic cell cycle GO:0051329 52 51 1,000 0,0180092 0,08874588 GO:0051325|interphase, ! cholesterol metabolic process GO:0008203 52 52 1,000 0,01868287 0,09182005 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 1,000 0,01868287 0,09157585 ! cell fate commitment GO:0045165 52 52 1,000 0,01868287 0,09133295 ! regulation of body fluid levels GO:0050878 55 52 1,000 0,01868287 0,09109132 ! response to light stimulus GO:0009416 53 52 1,000 0,01868287 0,09085098 ! regulation of T cell activation GO:0050863 53 53 1,000 0,01936712 0,09393054 ! protein amino acid dephosphorylation GO:0006470 55 54 1,000 0,02006188 0,09704474 ! sulfur metabolic process GO:0006790 55 54 1,000 0,02006188 0,09679069 ! rRNA transcription GO:0009303 5 5 0,000 0,0201897 0,09715306 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,0201897 0,09690005 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,0201897 0,09664837 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,0201897 0,09639798 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,0201897 0,09614889 ! reproductive cellular process GO:0048610 5 5 0,000 0,0201897 0,09590108 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,0201897 0,09565455 ! prostate gland development GO:0030850 5 5 0,000 0,0201897 0,09540928 ! metencephalon development GO:0022037 5 5 0,000 0,0201897 0,09516527 ! water transport GO:0006833 5 5 0,000 0,0201897 0,0949225 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,0201897 0,09468097 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,0201897 0,09444066 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,0201897 0,09420157 ! glycerol metabolic process GO:0006071 5 5 0,000 0,0201897 0,09396369 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,0201897 0,093727 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,0201897 0,09349151 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,0201897 0,0932572 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,0201897 0,09302405 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,0201897 0,09279207 ! filopodium assembly GO:0046847 7 5 0,000 0,0201897 0,09256125 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,0201897 0,09233157 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,0201897 0,09210302 ! GTP metabolic process GO:0046039 5 5 0,000 0,0201897 0,09187561 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,0201897 0,09164931 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,0201897 0,09142413 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,0201897 0,09120005 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,0201897 0,09097707 ! social behavior GO:0035176 5 5 0,000 0,0201897 0,09075517 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,0201897 0,09053436 ! memory GO:0007613 5 5 0,000 0,0201897 0,09031461 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,0201897 0,09009593 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,0201897 0,08987831 ! response to lipid GO:0033993 5 5 0,000 0,0201897 0,08966174 ! erythrocyte maturation GO:0043249 5 5 0,000 0,0201897 0,0894462 ! hippocampus development GO:0021766 6 5 0,000 0,0201897 0,0892317 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,0201897 0,08901823 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,0201897 0,08880578 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,0201897 0,08859434 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,0201897 0,0883839 ! mechanosensory behavior GO:0007638 5 5 0,000 0,0201897 0,08817446 ! heart looping GO:0001947 5 5 0,000 0,0201897 0,08796601 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,0201897 0,08775854 ! response to interferon-gamma GO:0034341 5 5 0,000 0,0201897 0,08755205 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,0201897 0,08734653 ! endocrine pancreas development GO:0031018 5 5 0,000 0,0201897 0,08714197 ! pH reduction GO:0045851 5 5 0,000 0,0201897 0,08693837 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,0201897 0,08673571 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,0201897 0,086534 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,0201897 0,08633323 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,0201897 0,08613338 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,0201897 0,08593446 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,0201897 0,08573645 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,0201897 0,08553936 ! adrenal gland development GO:0030325 5 5 0,000 0,0201897 0,08534317 ! melanocyte differentiation GO:0030318 5 5 0,000 0,0201897 0,08514787 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,0201897 0,08495347 ! astrocyte differentiation GO:0048708 5 5 0,000 0,0201897 0,08475996 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,0201897 0,08456732 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,0201897 0,08437556 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,0201897 0,08418466 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,0201897 0,08399463 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,0201897 0,08380545 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,0201897 0,08361713 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,0201897 0,08342964 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,0201897 0,083243 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,0201897 0,08305719 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,0201897 0,08287221 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,0201897 0,08268805 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,0201897 0,0825047 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,0201897 0,08232217 ! response to ATP GO:0033198 5 5 0,000 0,0201897 0,08214044 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,0201897 0,08195952 ! regulation of appetite GO:0032098 5 5 0,000 0,0201897 0,08177939 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,0201897 0,08160005 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,0201897 0,08142149 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,0201897 0,08124371 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,0201897 0,08106671 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,0201897 0,08089048 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,0201897 0,08071501 ! fear response GO:0042596 5 5 0,000 0,0201897 0,0805403 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,0201897 0,08036635 ! retinol metabolic process GO:0042572 5 5 0,000 0,0201897 0,08019315 ! temperature homeostasis GO:0001659 5 5 0,000 0,0201897 0,08002069 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,0201897 0,07984897 ! parturition GO:0007567 5 5 0,000 0,0201897 0,07967799 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,0201897 0,07950774 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,0201897 0,07933821 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,0201897 0,07916941 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,0201897 0,07900132 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,0201897 0,07883394 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,0201897 0,07866727 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,0201897 0,07850131 ! response to UV-B GO:0010224 5 5 0,000 0,0201897 0,07833604 ! oligodendrocyte development GO:0014003 5 5 0,000 0,0201897 0,07817147 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,0201897 0,07800759 ! activated T cell proliferation GO:0050798 5 5 0,000 0,0201897 0,0778444 ! interaction with symbiont GO:0051702 5 5 0,000 0,0201897 0,07768188 ! cellular extravasation GO:0045123 5 5 0,000 0,0201897 0,07752004 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,0201897 0,07735888 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,0201897 0,07719838 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,0201897 0,07703855 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,0201897 0,07687938 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,0201897 0,07672087 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,0201897 0,07656301 ! response to amine stimulus GO:0014075 5 5 0,000 0,0201897 0,07640579 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,0201897 0,07624922 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,0201897 0,07609329 ! neuron recognition GO:0008038 5 5 0,000 0,0201897 0,075938 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,0201897 0,07578334 ! decidualization GO:0046697 5 5 0,000 0,0201897 0,07562931 ! hair follicle maturation GO:0048820 5 5 0,000 0,0201897 0,0754759 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,0201897 0,07532312 ! regulation of mitochondrial membrane potential GO:0051881 5 5 0,000 0,0201897 0,07517095 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,0201897 0,0750194 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,0201897 0,07486845 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,0201897 0,07471811 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,0201897 0,07456838 ! postreplication repair GO:0006301 5 5 0,000 0,0201897 0,07441924 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,0201897 0,0742707 GO:0021517|ventral spinal cord development, ! cellular pigmentation GO:0033059 5 5 0,000 0,0201897 0,07412275 ! histone methylation GO:0016571 5 5 0,000 0,0201897 0,07397539 ! DNA methylation GO:0006306 5 5 0,000 0,0201897 0,07382861 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,0201897 0,07368242 ! T cell lineage commitment GO:0002360 5 5 0,000 0,0201897 0,0735368 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,0201897 0,07339176 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,0201897 0,07324729 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,0201897 0,07310338 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,0201897 0,07296004 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,0201897 0,07281726 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,0201897 0,07267504 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,0201897 0,07253337 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,0201897 0,07239226 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,0201897 0,07225169 ! sterol catabolic process GO:0016127 5 5 0,000 0,0201897 0,07211167 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,0201897 0,07197219 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,0201897 0,07183324 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,0201897 0,07169484 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,0201897 0,07155696 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,0201897 0,07141962 ! zymogen activation GO:0031638 5 5 0,000 0,0201897 0,0712828 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,0201897 0,0711465 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,0201897 0,07101073 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,0201897 0,07087547 ! peptidyl-lysine modification GO:0018205 5 5 0,000 0,0201897 0,07074072 ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 0,0201897 0,07060649 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,0201897 0,07047277 ! nucleosome positioning GO:0016584 5 5 0,000 0,0201897 0,07033955 ! regulation of isotype switching GO:0045191 5 5 0,000 0,0201897 0,07020683 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,0201897 0,07007462 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,0201897 0,0699429 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,0201897 0,06981167 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,0201897 0,06968094 ! NADPH regeneration GO:0006740 5 5 0,000 0,0201897 0,06955069 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,0201897 0,06942093 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,0201897 0,06929166 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,0201897 0,06916286 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,0201897 0,06903455 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,0201897 0,06890671 ! sarcomere organization GO:0045214 5 5 0,000 0,0201897 0,06877934 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,0201897 0,06865244 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,0201897 0,06852601 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,0201897 0,06840004 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,0201897 0,06827453 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 0,000 0,0201897 0,06814949 GO:0048599|oocyte development, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,0201897 0,0680249 ! regulation of protein homodimerization activity GO:0043496 6 5 0,000 0,0201897 0,06790077 ! spleen development GO:0048536 5 5 0,000 0,0201897 0,06777709 ! male genitalia development GO:0030539 5 5 0,000 0,0201897 0,06765386 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,0201897 0,06753107 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,0201897 0,06740873 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,0201897 0,06728684 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,0201897 0,06716538 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,0201897 0,06704436 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,0201897 0,06692378 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,0201897 0,06680363 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,0201897 0,06668391 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,0201897 0,06656462 ! ATP catabolic process GO:0006200 5 5 0,000 0,0201897 0,06644575 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,0201897 0,06632731 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,0201897 0,06620929 ! blastocyst formation GO:0001825 5 5 0,000 0,0201897 0,06609169 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,0201897 0,06597451 ! embryonic gut development GO:0048566 5 5 0,000 0,0201897 0,06585774 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,0201897 0,06574138 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,0201897 0,06562543 ! activation of innate immune response GO:0002218 5 5 0,000 0,0201897 0,0655099 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,0201897 0,06539476 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,0201897 0,06528004 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,0201897 0,06516571 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,0201897 0,06505178 ! embryonic heart tube development GO:0035050 5 5 0,000 0,0201897 0,06493826 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,0201897 0,06482512 ! defense response to fungus GO:0050832 5 5 0,000 0,0201897 0,06471238 ! lysogeny GO:0030069 5 5 0,000 0,0201897 0,06460004 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,0201897 0,06448808 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,0201897 0,06437651 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,0201897 0,06426532 ! response to nicotine GO:0035094 5 5 0,000 0,0201897 0,06415452 ! establishment of cell polarity GO:0030010 5 5 0,000 0,0201897 0,0640441 ! mitochondrion localization GO:0051646 5 5 0,000 0,0201897 0,06393406 ! nucleus localization GO:0051647 5 5 0,000 0,0201897 0,06382439 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,0201897 0,0637151 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,02076705 0,06542509 ! in utero embryonic development GO:0001701 55 55 1,000 0,02076705 0,06531344 ! regulation of cell adhesion GO:0030155 56 55 1,000 0,02076705 0,06520217 ! protein modification by small protein conjugation or removal GO:0070647 56 55 1,000 0,02076705 0,06509129 ! reproductive developmental process GO:0003006 56 56 1,000 0,02148255 0,06721958 ! extracellular structure organization GO:0043062 56 56 1,000 0,02148255 0,06710565 ! dephosphorylation GO:0016311 60 59 1,000 0,02369007 0,07387615 ! sterol metabolic process GO:0016125 59 59 1,000 0,02369007 0,07375136 ! axon extension GO:0048675 7 6 0,000 0,0241802 0,07515027 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,0241802 0,07502376 ! N-terminal protein amino acid modification GO:0031365 6 6 0,000 0,0241802 0,07489767 GO:0018409|peptide or protein amino-terminal blocking, ! tRNA modification GO:0006400 6 6 0,000 0,0241802 0,074772 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,0241802 0,07464675 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,0241802 0,07452193 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,0241802 0,07439752 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,0241802 0,07427352 ! regulation of S phase GO:0033261 6 6 0,000 0,0241802 0,07414994 ! myotube differentiation GO:0014902 6 6 0,000 0,0241802 0,07402677 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,0241802 0,073904 ! bone remodeling GO:0046849 6 6 0,000 0,0241802 0,07378164 ! N-glycan processing GO:0006491 6 6 0,000 0,0241802 0,07365969 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,0241802 0,07353814 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,0241802 0,07341699 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,0241802 0,07329624 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,0241802 0,07317588 ! RNA methylation GO:0001510 6 6 0,000 0,0241802 0,07305592 ! cartilage condensation GO:0001502 7 6 0,000 0,0241802 0,07293635 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,0241802 0,07281718 ! artery development GO:0060840 6 6 0,000 0,0241802 0,07269839 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,0241802 0,07257999 ! bile acid metabolic process GO:0008206 6 6 0,000 0,0241802 0,07246197 ! androgen metabolic process GO:0008209 6 6 0,000 0,0241802 0,07234434 ! estrogen metabolic process GO:0008210 6 6 0,000 0,0241802 0,07222709 ! limbic system development GO:0021761 7 6 0,000 0,0241802 0,07211021 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,0241802 0,07199372 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,0241802 0,0718776 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,0241802 0,07176186 ! pathogenesis GO:0009405 6 6 0,000 0,0241802 0,07164648 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,0241802 0,07153148 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,0241802 0,07141685 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,0241802 0,07130258 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,0241802 0,07118868 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,0241802 0,07107514 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,0241802 0,07096196 ! arginine metabolic process GO:0006525 6 6 0,000 0,0241802 0,07084915 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,0241802 0,07073669 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,0241802 0,07062458 ! glutamate catabolic process GO:0006538 7 6 0,000 0,0241802 0,07051284 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,0241802 0,07040144 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,0241802 0,0702904 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,0241802 0,0701797 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,0241802 0,07006936 ! V(D)J recombination GO:0033151 6 6 0,000 0,0241802 0,06995936 ! focal adhesion formation GO:0048041 7 6 0,000 0,0241802 0,06984971 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,0241802 0,0697404 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,0241802 0,06963143 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,0241802 0,0695228 ! regulation of heart rate GO:0002027 6 6 0,000 0,0241802 0,06941451 ! lipid digestion GO:0044241 6 6 0,000 0,0241802 0,06930655 ! asymmetric protein localization GO:0008105 6 6 0,000 0,0241802 0,06919893 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,0241802 0,06909165 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,0241802 0,06898469 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,0241802 0,06887807 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,0241802 0,06877178 ! ruffle organization GO:0031529 6 6 0,000 0,0241802 0,06866581 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,0241802 0,06856017 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,0241802 0,06845486 ! neutral amino acid transport GO:0015804 6 6 0,000 0,0241802 0,06834987 ! L-amino acid transport GO:0015807 6 6 0,000 0,0241802 0,0682452 ! bone mineralization GO:0030282 6 6 0,000 0,0241802 0,06814084 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,0241802 0,06803681 ! negative regulation of ossification GO:0030279 6 6 0,000 0,0241802 0,0679331 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,0241802 0,0678297 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,0241802 0,06772661 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,0241802 0,06762384 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 0,0241802 0,06752138 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,0241802 0,06741923 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,0241802 0,06731739 ! regulation of organ growth GO:0046620 6 6 0,000 0,0241802 0,06721586 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,0241802 0,06711463 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,0241802 0,0670137 ! response to dsRNA GO:0043331 6 6 0,000 0,0241802 0,06691308 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,0241802 0,06681276 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,0241802 0,06671274 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,0241802 0,06661302 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,0241802 0,0665136 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,0241802 0,06641447 ! multicellular organismal aging GO:0010259 6 6 0,000 0,0241802 0,06631564 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,0241802 0,06621711 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,0241802 0,06611886 ! erythrocyte development GO:0048821 6 6 0,000 0,0241802 0,06602091 ! renal water homeostasis GO:0003091 6 6 0,000 0,0241802 0,06592324 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,0241802 0,06582587 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,0241802 0,06572878 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,0241802 0,06563198 ! ribosome assembly GO:0042255 6 6 0,000 0,0241802 0,06553546 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,0241802 0,06543923 ! diencephalon development GO:0021536 6 6 0,000 0,0241802 0,06534327 ! fucose catabolic process GO:0019317 6 6 0,000 0,0241802 0,0652476 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,0241802 0,06515221 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,0241802 0,0650571 ! regulation of lipid transport GO:0032368 6 6 0,000 0,0241802 0,06496226 ! regulation of cell division GO:0051302 6 6 0,000 0,0241802 0,0648677 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,0241802 0,06477342 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,0241802 0,06467941 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,0241802 0,06458567 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,0241802 0,0644922 ! neuroblast proliferation GO:0007405 6 6 0,000 0,0241802 0,06439901 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,0241802 0,06430608 ! regulation of glucose transport GO:0010827 6 6 0,000 0,0241802 0,06421342 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,0241802 0,06412103 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,0241802 0,0640289 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,0241802 0,06393703 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,0241802 0,06384543 ! thymus development GO:0048538 6 6 0,000 0,0241802 0,0637541 ! lymph node development GO:0048535 6 6 0,000 0,0241802 0,06366302 ! organic cation transport GO:0015695 6 6 0,000 0,0241802 0,0635722 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,0241802 0,06348164 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,0241802 0,06339134 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,0241802 0,0633013 ! sperm-egg recognition GO:0035036 7 6 0,000 0,0241802 0,06321151 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,0241802 0,06312197 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,0241802 0,06303269 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,0241802 0,06294366 ! alditol metabolic process GO:0019400 6 6 0,000 0,0241802 0,06285488 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,0241802 0,06276636 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,0241802 0,06267808 ! maternal placenta development GO:0001893 6 6 0,000 0,0241802 0,06259005 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,0241802 0,06250226 ! protein polymerization GO:0051258 65 60 1,000 0,02444597 0,06310073 ! axonogenesis GO:0007409 66 62 1,000 0,02598732 0,0669855 ! regulation of lymphocyte activation GO:0051249 62 62 1,000 0,02598732 0,06689194 ! regulation of secretion GO:0051046 65 63 1,000 0,0267726 0,06881716 ! angiogenesis GO:0001525 65 64 1,000 0,0275675 0,07076171 ! regulation of cytoskeleton organization GO:0051493 66 64 1,000 0,0275675 0,07066329 ! respiratory burst GO:0045730 7 7 0,000 0,02815503 0,07206905 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,02815503 0,07196909 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,02815503 0,07186941 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,02815503 0,07177001 ! regulation of chemokine production GO:0032642 7 7 0,000 0,02815503 0,07167088 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,02815503 0,07157202 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,02815503 0,07147344 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,02815503 0,07137513 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,02815503 0,07127708 GO:0043241|protein complex disassembly, ! hair follicle morphogenesis GO:0031069 7 7 0,000 0,02815503 0,07117931 ! gene silencing by RNA GO:0031047 7 7 0,000 0,02815503 0,0710818 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,02815503 0,07098456 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,02815503 0,07088759 ! axis specification GO:0009798 7 7 0,000 0,02815503 0,07079088 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,02815503 0,07069444 ! visual behavior GO:0007632 7 7 0,000 0,02815503 0,07059825 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,02815503 0,07050233 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,02815503 0,07040667 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,02815503 0,07031127 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,02815503 0,07021613 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,02815503 0,07012124 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,02815503 0,07002661 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,02815503 0,06993223 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,02815503 0,06983811 ! digestive system development GO:0055123 7 7 0,000 0,02815503 0,06974424 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,02815503 0,06965063 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,02815503 0,06955726 ! protein targeting to ER GO:0045047 8 7 0,000 0,02815503 0,06946415 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,02815503 0,06937128 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,02815503 0,06927866 ! endoderm development GO:0007492 7 7 0,000 0,02815503 0,06918629 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,02815503 0,06909416 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,02815503 0,06900228 GO:0006688|glycosphingolipid biosynthetic process, ! response to hexose stimulus GO:0009746 7 7 0,000 0,02815503 0,06891065 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,02815503 0,06881925 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,02815503 0,0687281 ! regulation of skeletal muscle fiber development GO:0048742 7 7 0,000 0,02815503 0,06863719 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,02815503 0,06854652 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,02815503 0,06845609 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,02815503 0,0683659 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,02815503 0,06827594 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,02815503 0,06818622 ! response to X-ray GO:0010165 7 7 0,000 0,02815503 0,06809674 ! regulation of intracellular pH GO:0051453 7 7 0,000 0,02815503 0,06800749 ! UV protection GO:0009650 7 7 0,000 0,02815503 0,06791848 ! DNA integration GO:0015074 7 7 0,000 0,02815503 0,0678297 ! myofibril assembly GO:0030239 7 7 0,000 0,02815503 0,06774114 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,02815503 0,06765283 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,02815503 0,06756474 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,02815503 0,06747688 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,02815503 0,06738924 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,02815503 0,06730184 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,02815503 0,06721466 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,02815503 0,06712771 GO:0019827|stem cell maintenance, ! alpha-beta T cell differentiation GO:0046632 7 7 0,000 0,02815503 0,06704098 ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,02815503 0,06695447 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,02815503 0,06686819 ! eating behavior GO:0042755 7 7 0,000 0,02815503 0,06678213 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,02815503 0,06669629 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,02815503 0,06661068 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,02815503 0,06652528 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,02815503 0,0664401 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,02815503 0,06635514 ! cranial nerve development GO:0021545 7 7 0,000 0,02815503 0,06627039 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,02815503 0,06618586 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,02815503 0,06610155 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,02815503 0,06601745 ! autonomic nervous system development GO:0048483 7 7 0,000 0,02815503 0,06593357 ! intracellular lipid transport GO:0032365 7 7 0,000 0,02815503 0,06584989 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,02815503 0,06576643 ! platelet activation GO:0030168 8 7 0,000 0,02815503 0,06568319 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,02815503 0,06560015 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,02815503 0,06551732 ! natural killer cell activation GO:0030101 7 7 0,000 0,02815503 0,0654347 ! response to gamma radiation GO:0010332 8 7 0,000 0,02815503 0,06535229 ! NADP metabolic process GO:0006739 7 7 0,000 0,02815503 0,06527008 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,02815503 0,06518809 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,02815503 0,06510629 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,02815503 0,06502471 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,02815503 0,06494333 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,02815503 0,06486215 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,02815503 0,06478117 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,02815503 0,0647004 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,02815503 0,06461982 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,02815503 0,06453945 ! cell-cell recognition GO:0009988 8 7 0,000 0,02815503 0,06445928 ! hormone catabolic process GO:0042447 7 7 0,000 0,02815503 0,0643793 ! dopamine metabolic process GO:0042417 7 7 0,000 0,02815503 0,06429953 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,02815503 0,06421995 ! oxygen transport GO:0015671 7 7 0,000 0,02815503 0,06414056 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,02815503 0,06406138 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,02815503 0,06398239 ! regulation of axon extension GO:0030516 7 7 0,000 0,02815503 0,06390359 ! cell killing GO:0001906 7 7 0,000 0,02815503 0,06382499 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,02815503 0,06374658 ! adult feeding behavior GO:0008343 7 7 0,000 0,02815503 0,06366836 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,02815503 0,06359034 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,02815503 0,06351251 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,02815503 0,06343486 ! response to cold GO:0009409 7 7 0,000 0,02815503 0,06335741 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,02918584 0,06559695 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 0,02918584 0,06551705 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 1,000 0,0300091 0,06728317 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! response to radiation GO:0009314 70 68 1,000 0,03084164 0,06906579 ! response to nutrient levels GO:0031667 69 69 1,000 0,03168339 0,07086466 ! regulation of leukocyte activation GO:0002694 69 69 1,000 0,03168339 0,07077877 ! regulation of skeletal muscle tissue development GO:0048641 8 8 0,000 0,03211424 0,07165441 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,03211424 0,07156777 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,03211424 0,07148133 ! positive regulation of translation GO:0045727 8 8 0,000 0,03211424 0,07139511 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,03211424 0,07130909 ! superoxide anion generation GO:0042554 8 8 0,000 0,03211424 0,07122328 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,03211424 0,07113767 ! cGMP metabolic process GO:0046068 8 8 0,000 0,03211424 0,07105227 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,03211424 0,07096708 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,03211424 0,07088209 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,03211424 0,0707973 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,03211424 0,07071272 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,03211424 0,07062833 ! zinc ion transport GO:0006829 8 8 0,000 0,03211424 0,07054415 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,03211424 0,07046017 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,03211424 0,07037639 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,03211424 0,07029281 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,03211424 0,07020942 ! lipid localization GO:0010876 8 8 0,000 0,03211424 0,07012624 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,03211424 0,07004325 ! response to cAMP GO:0051591 8 8 0,000 0,03211424 0,06996045 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,03211424 0,06987786 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,03211424 0,06979545 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,03211424 0,06971324 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,03211424 0,06963123 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,03211424 0,0695494 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,03211424 0,06946777 ! sensory perception of taste GO:0050909 8 8 0,000 0,03211424 0,06938633 ! organelle fusion GO:0048284 8 8 0,000 0,03211424 0,06930509 ! pancreas development GO:0031016 8 8 0,000 0,03211424 0,06922403 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,03211424 0,06914316 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! T cell selection GO:0045058 8 8 0,000 0,03211424 0,06906248 ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,03211424 0,06898199 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,03211424 0,06890168 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,03211424 0,06882156 ! sperm motility GO:0030317 8 8 0,000 0,03211424 0,06874163 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,03211424 0,06866188 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,03211424 0,06858232 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,03211424 0,06850294 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,03211424 0,06842375 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,03211424 0,06834474 GO:0031114|regulation of microtubule depolymerization, ! polyamine metabolic process GO:0006595 8 8 0,000 0,03211424 0,06826591 ! Golgi organization GO:0007030 8 8 0,000 0,03211424 0,06818726 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,03211424 0,0681088 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,03211424 0,06803051 ! fructose metabolic process GO:0006000 8 8 0,000 0,03211424 0,0679524 ! mannose metabolic process GO:0006013 9 8 0,000 0,03211424 0,06787448 ! NAD metabolic process GO:0019674 8 8 0,000 0,03211424 0,06779673 ! negative regulation of mitotic cell cycle GO:0045930 9 8 0,000 0,03211424 0,06771916 ! plasma membrane fusion GO:0045026 8 8 0,000 0,03211424 0,06764176 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,03211424 0,06756455 ! response to fungus GO:0009620 8 8 0,000 0,03211424 0,06748751 ! stem cell differentiation GO:0048863 8 8 0,000 0,03211424 0,06741064 ! alpha-beta T cell activation GO:0046631 8 8 0,000 0,03211424 0,06733395 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,03211424 0,06725744 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,03211424 0,06718109 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,03211424 0,06710492 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,03211424 0,06702893 ! regulation of vasodilation GO:0042312 8 8 0,000 0,03211424 0,0669531 ! vasoconstriction GO:0042310 8 8 0,000 0,03211424 0,06687745 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,03211424 0,06680197 ! muscle cell development GO:0055001 8 8 0,000 0,03211424 0,06672666 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,03211424 0,06665151 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,03211424 0,06657654 ! sensory perception of pain GO:0019233 8 8 0,000 0,03211424 0,06650173 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,03211424 0,0664271 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,03211424 0,06635263 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,03211424 0,06627832 ! chromatin silencing GO:0006342 8 8 0,000 0,03211424 0,06620419 ! tissue regeneration GO:0042246 8 8 0,000 0,03211424 0,06613022 ! salivary gland development GO:0007431 8 8 0,000 0,03211424 0,06605641 ! T cell homeostasis GO:0043029 8 8 0,000 0,03211424 0,06598277 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,03211424 0,06590929 ! water homeostasis GO:0030104 8 8 0,000 0,03211424 0,06583598 ! cofactor transport GO:0051181 8 8 0,000 0,03211424 0,06576283 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,03211424 0,06568984 ! acid secretion GO:0046717 8 8 0,000 0,03211424 0,06561701 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,03211424 0,06554434 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,03211424 0,06547184 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,03211424 0,0653995 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,03211424 0,06532731 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,03211424 0,06525528 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,03211424 0,06518342 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,03211424 0,06511171 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,03211424 0,06504016 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,03211424 0,06496876 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,03211424 0,06489753 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,03211424 0,06482644 ! peptide hormone secretion GO:0030072 8 8 0,000 0,03211424 0,06475552 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,03211424 0,06468475 ! actin filament polymerization GO:0030041 9 8 0,000 0,03211424 0,06461413 ! peptide hormone processing GO:0016486 8 8 0,000 0,03211424 0,06454367 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,03211424 0,06447336 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,03211424 0,0644032 ! cell part morphogenesis GO:0032990 75 70 1,000 0,03253425 0,06517459 ! growth GO:0040007 70 70 1,000 0,03253425 0,06510383 ! negative regulation of signal transduction GO:0009968 71 71 1,000 0,03339415 0,06675208 ! muscle system process GO:0003012 72 72 1,000 0,034263 0,06841465 ! response to extracellular stimulus GO:0009991 72 72 1,000 0,034263 0,0683406 ! regulation of cytokine production GO:0001817 72 72 1,000 0,034263 0,06826672 ! electron transport chain GO:0022900 75 74 1,000 0,03602725 0,07170434 ! lactation GO:0007595 10 9 0,000 0,0360579 0,07168792 ! embryonic pattern specification GO:0009880 10 9 0,000 0,0360579 0,07161067 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,0360579 0,07153359 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,0360579 0,07145667 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,0360579 0,07137991 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,0360579 0,07130333 ! negative regulation of cell cycle process GO:0010948 9 9 0,000 0,0360579 0,0712269 ! viral genome replication GO:0019079 9 9 0,000 0,0360579 0,07115064 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,0360579 0,07107455 ! copper ion transport GO:0006825 9 9 0,000 0,0360579 0,07099861 ! lipid phosphorylation GO:0046834 9 9 0,000 0,0360579 0,07092284 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,0360579 0,07084723 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,0360579 0,07077178 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,0360579 0,07069649 ! RNA polyadenylation GO:0043631 9 9 0,000 0,0360579 0,07062136 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,0360579 0,07054639 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,0360579 0,07047158 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,0360579 0,07039693 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,0360579 0,07032243 ! phospholipid efflux GO:0033700 9 9 0,000 0,0360579 0,0702481 ! response to alkaloid GO:0043279 10 9 0,000 0,0360579 0,07017392 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,0360579 0,0700999 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,0360579 0,07002603 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,0360579 0,06995232 ! response to ethanol GO:0045471 9 9 0,000 0,0360579 0,06987876 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,0360579 0,06980536 ! activation of pro-apoptotic gene products GO:0008633 9 9 0,000 0,0360579 0,06973211 ! methionine metabolic process GO:0006555 9 9 0,000 0,0360579 0,06965902 ! glutamine metabolic process GO:0006541 9 9 0,000 0,0360579 0,06958607 ! cerebral cortex development GO:0021987 9 9 0,000 0,0360579 0,06951329 ! response to osmotic stress GO:0006970 9 9 0,000 0,0360579 0,06944065 ! pigmentation during development GO:0048066 9 9 0,000 0,0360579 0,06936816 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,0360579 0,06929583 ! central nervous system neuron development GO:0021954 10 9 0,000 0,0360579 0,06922365 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,0360579 0,06915161 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,0360579 0,06907973 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,0360579 0,069008 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 0,000 0,0360579 0,06893641 GO:0060675|ureteric bud morphogenesis, ! L-glutamate transport GO:0015813 9 9 0,000 0,0360579 0,06886497 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,0360579 0,06879369 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,0360579 0,06872254 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,0360579 0,06865155 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,0360579 0,0685807 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,0360579 0,06851 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,0360579 0,06843944 ! DNA replication initiation GO:0006270 9 9 0,000 0,0360579 0,06836903 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,0360579 0,06829877 GO:0006692|prostanoid metabolic process, ! T cell differentiation in the thymus GO:0033077 9 9 0,000 0,0360579 0,06822865 ! regulation of cellular pH GO:0030641 9 9 0,000 0,0360579 0,06815867 ! histone acetylation GO:0016573 9 9 0,000 0,0360579 0,06808883 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,0360579 0,06801914 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,0360579 0,06794959 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,0360579 0,06788018 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,0360579 0,06781092 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,0360579 0,06774179 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,0360579 0,06767281 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,0360579 0,06760397 ! collagen catabolic process GO:0030574 9 9 0,000 0,0360579 0,06753526 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,0360579 0,0674667 ! purine base metabolic process GO:0006144 9 9 0,000 0,0360579 0,06739828 ! gas transport GO:0015669 9 9 0,000 0,0360579 0,06732999 ! cholesterol efflux GO:0033344 9 9 0,000 0,0360579 0,06726184 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,0360579 0,06719383 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,0360579 0,06712596 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,0360579 0,06705822 ! defense response to virus GO:0051607 9 9 0,000 0,0360579 0,06699063 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,0360579 0,06692316 ! actin filament-based movement GO:0030048 9 9 0,000 0,0360579 0,06685584 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,0360579 0,06678864 ! negative regulation of cell communication GO:0010648 76 76 1,000 0,03782634 0,06999391 ! cell morphogenesis involved in differentiation GO:0000904 82 77 1,000 0,03873875 0,07161034 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,03998605 0,07384198 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,03998605 0,07376807 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,03998605 0,0736943 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,03998605 0,07362068 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,03998605 0,0735472 ! neuron maturation GO:0042551 10 10 0,000 0,03998605 0,07347388 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,03998605 0,07340069 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,03998605 0,07332766 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,03998605 0,07325477 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,03998605 0,07318202 ! hormone secretion GO:0046879 10 10 0,000 0,03998605 0,07310942 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,03998605 0,07303696 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,03998605 0,07296465 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inositol metabolic process GO:0006020 10 10 0,000 0,03998605 0,07289248 ! cAMP metabolic process GO:0046058 10 10 0,000 0,03998605 0,07282045 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,03998605 0,07274857 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,03998605 0,07267682 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,03998605 0,07260522 ! glial cell development GO:0021782 10 10 0,000 0,03998605 0,07253376 ! phototransduction GO:0007602 11 10 0,000 0,03998605 0,07246244 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,03998605 0,07239125 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,03998605 0,07232021 ! fat cell differentiation GO:0045444 10 10 0,000 0,03998605 0,07224931 ! myoblast differentiation GO:0045445 10 10 0,000 0,03998605 0,07217855 ! centrosome cycle GO:0007098 10 10 0,000 0,03998605 0,07210792 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,03998605 0,07203744 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,03998605 0,07196709 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,03998605 0,07189688 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,03998605 0,0718268 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,03998605 0,07175686 ! epidermis morphogenesis GO:0048730 10 10 0,000 0,03998605 0,07168706 ! protein polyubiquitination GO:0000209 10 10 0,000 0,03998605 0,07161739 ! glutamate metabolic process GO:0006536 11 10 0,000 0,03998605 0,07154786 ! plasma membrane organization GO:0007009 10 10 0,000 0,03998605 0,07147846 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,03998605 0,0714092 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-substrate junction assembly GO:0007044 11 10 0,000 0,03998605 0,07134007 ! lysosomal transport GO:0007041 10 10 0,000 0,03998605 0,07127108 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,03998605 0,07120222 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,03998605 0,07113349 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,03998605 0,0710649 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,03998605 0,07099643 ! exocrine system development GO:0035272 10 10 0,000 0,03998605 0,0709281 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,03998605 0,0708599 ! embryo implantation GO:0007566 11 10 0,000 0,03998605 0,07079183 ! regulation of protein binding GO:0043393 11 10 0,000 0,03998605 0,07072389 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,03998605 0,07065609 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,03998605 0,07058841 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,03998605 0,07052086 ! protein export from nucleus GO:0006611 10 10 0,000 0,03998605 0,07045344 ! negative regulation of immune response GO:0050777 10 10 0,000 0,03998605 0,07038615 ! cytolysis GO:0019835 10 10 0,000 0,03998605 0,07031899 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,03998605 0,07025195 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,03998605 0,07018505 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,03998605 0,07011827 ! histone deacetylation GO:0016575 10 10 0,000 0,03998605 0,07005161 ! mRNA splice site selection GO:0006376 11 10 0,000 0,03998605 0,06998509 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,03998605 0,06991869 ! gland morphogenesis GO:0022612 10 10 0,000 0,03998605 0,06985241 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,03998605 0,06978627 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,03998605 0,06972024 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,03998605 0,06965435 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,03998605 0,06958857 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,03998605 0,06952292 ! regulation of epidermis development GO:0045682 10 10 0,000 0,03998605 0,0694574 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,03998605 0,06939199 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,03998605 0,06932671 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,03998605 0,06926156 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,03998605 0,06919652 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,03998605 0,06913161 ! lymphocyte homeostasis GO:0002260 10 10 0,000 0,03998605 0,06906682 ! nerve development GO:0021675 10 10 0,000 0,03998605 0,06900215 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,03998605 0,0689376 ! gut development GO:0048565 10 10 0,000 0,03998605 0,06887318 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,03998605 0,06880887 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,03998605 0,06874468 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,03998605 0,06868061 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,03998605 0,06861666 ! neuron projection development GO:0031175 85 80 1,000 0,0415265 0,07119381 ! protein secretion GO:0009306 11 11 0,000 0,04389877 0,07519093 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,04389877 0,07512112 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,04389877 0,07505143 ! negative regulation of defense response GO:0031348 11 11 0,000 0,04389877 0,07498187 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,04389877 0,07491245 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,04389877 0,07484315 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,04389877 0,07477398 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,04389877 0,07470493 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,04389877 0,07463602 ! endothelial cell migration GO:0043542 11 11 0,000 0,04389877 0,07456723 ! peroxisomal transport GO:0043574 11 11 0,000 0,04389877 0,07449856 ! protein amino acid acetylation GO:0006473 11 11 0,000 0,04389877 0,07443003 ! heart contraction GO:0060047 11 11 0,000 0,04389877 0,07436162 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,04389877 0,07429333 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,04389877 0,07422518 ! T cell proliferation GO:0042098 11 11 0,000 0,04389877 0,07415714 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,04389877 0,07408923 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,04389877 0,07402145 ! regulation of viral genome replication GO:0045069 11 11 0,000 0,04389877 0,07395379 ! spinal cord development GO:0021510 11 11 0,000 0,04389877 0,07388625 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,04389877 0,07381883 ! smooth muscle contraction GO:0006939 11 11 0,000 0,04389877 0,07375154 ! cellular response to starvation GO:0009267 11 11 0,000 0,04389877 0,07368437 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,04389877 0,07361733 ! digestive system process GO:0022600 11 11 0,000 0,04389877 0,0735504 ! mitotic spindle organization GO:0007052 11 11 0,000 0,04389877 0,0734836 ! fucose metabolic process GO:0006004 11 11 0,000 0,04389877 0,07341692 ! membrane budding GO:0006900 11 11 0,000 0,04389877 0,07335035 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,04389877 0,07328391 ! monoamine transport GO:0015844 11 11 0,000 0,04389877 0,07321759 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,04389877 0,07315139 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,04389877 0,07308531 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,04389877 0,07301935 ! body fluid secretion GO:0007589 11 11 0,000 0,04389877 0,07295351 ! G1/S transition checkpoint GO:0031575 12 11 0,000 0,04389877 0,07288778 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,04389877 0,07282218 ! membrane depolarization GO:0051899 11 11 0,000 0,04389877 0,07275669 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,04389877 0,07269132 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,04389877 0,07262607 ! oogenesis GO:0048477 11 11 0,000 0,04389877 0,07256093 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,04389877 0,07249592 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,04389877 0,07243101 ! vitamin transport GO:0051180 11 11 0,000 0,04389877 0,07236623 ! muscle maintenance GO:0046716 12 11 0,000 0,04389877 0,07230156 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,04389877 0,072237 ! hindbrain development GO:0030902 11 11 0,000 0,04389877 0,07217256 ! steroid catabolic process GO:0006706 11 11 0,000 0,04389877 0,07210824 ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,04389877 0,07204403 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,04389877 0,07197993 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,04389877 0,07191595 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,04389877 0,07185208 ! cellular amino acid derivative metabolic process GO:0006575 87 84 1,000 0,04535848 0,07417541 ! translational initiation GO:0006413 12 12 0,000 0,04779612 0,07809241 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,04779612 0,07802324 ! initiation of viral infection GO:0019059 12 12 0,000 0,04779612 0,0779542 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,04779612 0,07788527 ! iron ion transport GO:0006826 13 12 0,000 0,04779612 0,07781647 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,04779612 0,07774779 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,04779612 0,07767922 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,04779612 0,07761078 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,04779612 0,07754247 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,04779612 0,07747427 ! collagen metabolic process GO:0032963 12 12 0,000 0,04779612 0,07740619 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,04779612 0,07733823 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,04779612 0,07727039 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,04779612 0,07720266 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,04779612 0,07713506 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,04779612 0,07706758 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,04779612 0,07700021 GO:0042744|hydrogen peroxide catabolic process, ! actomyosin structure organization GO:0031032 12 12 0,000 0,04779612 0,07693296 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,04779612 0,07686583 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,04779612 0,07679881 ! retinoid metabolic process GO:0001523 12 12 0,000 0,04779612 0,07673192 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,04779612 0,07666514 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,04779612 0,07659847 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,04779612 0,07653192 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,04779612 0,07646549 ! acute-phase response GO:0006953 12 12 0,000 0,04779612 0,07639917 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,04779612 0,07633296 ! vacuolar transport GO:0007034 12 12 0,000 0,04779612 0,07626687 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,04779612 0,0762009 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,04779612 0,07613504 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,04779612 0,07606929 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,04779612 0,07600366 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,04779612 0,07593814 ! male gonad development GO:0008584 12 12 0,000 0,04779612 0,07587273 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,04779612 0,07580744 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,04779612 0,07574225 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,04779612 0,07567718 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,04779612 0,07561222 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,04779612 0,07554738 ! pallium development GO:0021543 13 12 0,000 0,04779612 0,07548264 ! cell fate determination GO:0001709 12 12 0,000 0,04779612 0,07541801 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,04779612 0,0753535 ! somitogenesis GO:0001756 13 12 0,000 0,04779612 0,07528909 ! G1 phase GO:0051318 13 12 0,000 0,04779612 0,0752248 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,04779612 0,07516061 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,04779612 0,07509654 ! detection of light stimulus GO:0009583 13 12 0,000 0,04779612 0,07503257 ! synaptogenesis GO:0007416 12 12 0,000 0,04779612 0,07496872 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,04779612 0,07490497 ! hormone transport GO:0009914 12 12 0,000 0,04779612 0,07484133 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,04779612 0,07477779 ! heme biosynthetic process GO:0006783 12 12 0,000 0,04779612 0,07471437 ! spermatid differentiation GO:0048515 13 12 0,000 0,04779612 0,07465105 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,04779612 0,07458784 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,04779612 0,07452474 ! neural tube closure GO:0001843 13 12 0,000 0,04779612 0,07446174 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 0,000 0,04779612 0,07439885 ! negative regulation of translation GO:0017148 12 12 0,000 0,04779612 0,07433607 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,04779612 0,07427339 ! chemotaxis GO:0006935 90 89 1,000 0,05032638 0,07813943 GO:0042330|taxis, ! brain development GO:0007420 91 90 1,000 0,05134293 0,07965068 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,05167813 0,08010328 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,05167813 0,08003597 ! phenol metabolic process GO:0018958 13 13 0,000 0,05167813 0,07996877 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,05167813 0,07990168 ! gluconeogenesis GO:0006094 13 13 0,000 0,05167813 0,0798347 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,05167813 0,07976784 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,05167813 0,07970109 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,05167813 0,07963445 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,05167813 0,07956792 ! regeneration GO:0031099 13 13 0,000 0,05167813 0,0795015 ! keratinization GO:0031424 13 13 0,000 0,05167813 0,0794352 ! post-embryonic development GO:0009791 14 13 0,000 0,05167813 0,079369 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,05167813 0,07930292 ! patterning of blood vessels GO:0001569 13 13 0,000 0,05167813 0,07923694 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,05167813 0,07917107 ! regulation of innate immune response GO:0045088 13 13 0,000 0,05167813 0,07910532 ! mitochondrial membrane organization GO:0007006 13 13 0,000 0,05167813 0,07903967 ! negative regulation of DNA replication GO:0008156 13 13 0,000 0,05167813 0,07897413 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,05167813 0,0789087 ! response to corticosteroid stimulus GO:0031960 13 13 0,000 0,05167813 0,07884338 GO:0051384|response to glucocorticoid stimulus, ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,05167813 0,07877817 ! autophagy GO:0006914 13 13 0,000 0,05167813 0,07871306 ! actin filament bundle formation GO:0051017 13 13 0,000 0,05167813 0,07864806 ! ureteric bud development GO:0001657 13 13 0,000 0,05167813 0,07858317 ! cell aging GO:0007569 13 13 0,000 0,05167813 0,07851839 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,05167813 0,07845371 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,05167813 0,07838914 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,05167813 0,07832467 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,05167813 0,07826031 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,05167813 0,07819606 ! regulation of viral reproduction GO:0050792 13 13 0,000 0,05167813 0,07813191 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,05167813 0,07806787 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,05167813 0,07800393 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,05167813 0,0779401 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,05167813 0,07787637 ! vasodilation GO:0042311 14 13 0,000 0,05167813 0,07781275 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,05167813 0,07774923 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,05167813 0,07768581 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,05167813 0,0776225 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,05167813 0,07755929 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,05167813 0,07749618 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,05167813 0,07743317 ! immunoglobulin production GO:0002377 13 13 0,000 0,05167813 0,07737027 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,05167813 0,07730747 ! cell-cell junction organization GO:0045216 13 13 0,000 0,05167813 0,07724477 ! regulation of cell-substrate adhesion GO:0010810 14 13 0,000 0,05167813 0,07718217 GO:0001952|regulation of cell-matrix adhesion, ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,05167813 0,07711968 ! response to cytokine stimulus GO:0034097 13 13 0,000 0,05167813 0,07705728 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,05167813 0,07699499 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,05167813 0,0769328 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,05167813 0,0768707 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,05167813 0,07680871 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,05167813 0,07674682 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,05167813 0,07668503 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,05167813 0,07662333 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,05167813 0,07656174 ! blastocyst development GO:0001824 13 13 0,000 0,05167813 0,07650024 ! telomere organization GO:0032200 13 13 0,000 0,05167813 0,07643885 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,05167813 0,07637755 ! regulation of amine transport GO:0051952 13 13 0,000 0,05167813 0,07631635 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,05167813 0,07625525 ! negative regulation of cell cycle GO:0045786 92 91 1,000 0,05236696 0,07720985 ! DNA replication GO:0006260 91 91 1,000 0,05236696 0,07714813 ! fatty acid metabolic process GO:0006631 93 92 1,000 0,05339841 0,07860485 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 1,000 0,05339841 0,07854212 ! positive regulation of immune system process GO:0002684 92 92 1,000 0,05339841 0,07847948 ! tissue morphogenesis GO:0048729 94 93 1,000 0,0544372 0,07994244 ! epidermis development GO:0008544 94 94 1,000 0,05548326 0,08141373 ! neuron fate commitment GO:0048663 14 14 0,000 0,05554489 0,08143933 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,05554489 0,08137459 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,05554489 0,08130995 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,05554489 0,08124542 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,05554489 0,08118099 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,05554489 0,08111667 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,05554489 0,08105244 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,05554489 0,08098832 ! protein amino acid acylation GO:0043543 14 14 0,000 0,05554489 0,08092429 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,05554489 0,08086037 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,05554489 0,08079655 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,05554489 0,08073283 ! vesicle docking GO:0048278 14 14 0,000 0,05554489 0,08066921 ! superoxide metabolic process GO:0006801 15 14 0,000 0,05554489 0,0806057 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,05554489 0,08054228 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,05554489 0,08047896 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,05554489 0,08041574 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,05554489 0,08035262 ! hair cycle GO:0042633 14 14 0,000 0,05554489 0,08028959 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,05554489 0,08022667 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,05554489 0,08016385 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! multicellular organismal response to stress GO:0033555 14 14 0,000 0,05554489 0,08010112 ! lysosome organization GO:0007040 14 14 0,000 0,05554489 0,08003849 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,05554489 0,07997596 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,05554489 0,07991353 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,05554489 0,0798512 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 0,000 0,05554489 0,07978896 ! primary neural tube formation GO:0014020 15 14 0,000 0,05554489 0,07972682 ! peptide cross-linking GO:0018149 14 14 0,000 0,05554489 0,07966477 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,05554489 0,07960283 ! base-excision repair GO:0006284 14 14 0,000 0,05554489 0,07954097 ! response to organic cyclic substance GO:0014070 15 14 0,000 0,05554489 0,07947922 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,05554489 0,07941756 ! formation of primary germ layer GO:0001704 14 14 0,000 0,05554489 0,07935599 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,05554489 0,07929453 ! collagen fibril organization GO:0030199 14 14 0,000 0,05554489 0,07923315 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,05554489 0,07917187 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,05554489 0,07911069 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,05554489 0,0790496 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,05554489 0,07898861 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,05554489 0,0789277 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,05554489 0,0788669 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,05554489 0,07880618 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,05939644 0,08420588 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,05939644 0,08414115 ! positive regulation of ossification GO:0045778 15 15 0,000 0,05939644 0,08407653 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,05939644 0,084012 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,05939644 0,08394758 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,05939644 0,08388325 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,05939644 0,08381902 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,05939644 0,08375489 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,05939644 0,08369086 ! ovarian follicle development GO:0001541 15 15 0,000 0,05939644 0,08362692 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,05939644 0,08356308 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,05939644 0,08349934 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,05939644 0,0834357 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,05939644 0,08337216 ! heme metabolic process GO:0042168 15 15 0,000 0,05939644 0,08330871 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,05939644 0,08324535 ! chromosome condensation GO:0030261 15 15 0,000 0,05939644 0,0831821 ! response to starvation GO:0042594 15 15 0,000 0,05939644 0,08311894 ! response to ionizing radiation GO:0010212 16 15 0,000 0,05939644 0,08305587 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,05939644 0,0829929 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,05939644 0,08293003 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,05939644 0,08286725 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,05939644 0,08280457 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,05939644 0,08274198 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,05939644 0,08267949 ! phospholipid transport GO:0015914 15 15 0,000 0,05939644 0,08261709 ! leukocyte homeostasis GO:0001776 15 15 0,000 0,05939644 0,08255478 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,05939644 0,08249257 ! glutathione metabolic process GO:0006749 16 15 0,000 0,05939644 0,08243045 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,05939644 0,08236843 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,05939644 0,0823065 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,05939644 0,08224466 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,05939644 0,08218291 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,05939644 0,08212126 ! protein homooligomerization GO:0051260 15 15 0,000 0,05939644 0,0820597 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,05939644 0,08199823 ! regulation of system process GO:0044057 98 98 1,000 0,05973875 0,08240907 ! ectoderm development GO:0007398 99 99 1,000 0,06082009 0,08383801 ! hemopoiesis GO:0030097 104 100 1,000 0,06190827 0,08527425 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,06323284 0,0870337 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,06323284 0,08696875 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,06323284 0,0869039 ! learning GO:0007612 16 16 0,000 0,06323284 0,08683914 ! circadian rhythm GO:0007623 16 16 0,000 0,06323284 0,08677448 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,06323284 0,08670992 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,06323284 0,08664545 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,06323284 0,08658108 ! vacuole organization GO:0007033 16 16 0,000 0,06323284 0,0865168 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,06323284 0,08645262 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,06323284 0,08638853 ! vesicle targeting GO:0006903 17 16 0,000 0,06323284 0,08632454 ! segmentation GO:0035282 17 16 0,000 0,06323284 0,08626064 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,06323284 0,08619684 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,06323284 0,08613313 ! iron ion homeostasis GO:0055072 16 16 0,000 0,06323284 0,08606952 ! positive regulation of cell development GO:0010720 16 16 0,000 0,06323284 0,086006 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,06323284 0,08594257 ! lymphocyte proliferation GO:0046651 16 16 0,000 0,06323284 0,08587924 ! pentose metabolic process GO:0019321 16 16 0,000 0,06323284 0,085816 ! fatty acid transport GO:0015908 16 16 0,000 0,06323284 0,08575285 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,06323284 0,0856898 ! cellular response to nutrient levels GO:0031669 16 16 0,000 0,06323284 0,08562684 ! cofactor catabolic process GO:0051187 16 16 0,000 0,06323284 0,08556397 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,06323284 0,0855012 ! polyol metabolic process GO:0019751 16 16 0,000 0,06323284 0,08543851 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,06323284 0,08537592 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,06323284 0,08531342 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,06323284 0,08525101 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,06323284 0,08518869 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,06323284 0,08512646 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,06323284 0,08506433 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,06323284 0,08500228 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,06705415 0,09007347 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,06705415 0,09000787 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,06705415 0,08994236 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,06705415 0,08987695 ! leukocyte adhesion GO:0007159 17 17 0,000 0,06705415 0,08981163 ! sensory perception of smell GO:0007608 17 17 0,000 0,06705415 0,08974641 ! cell junction assembly GO:0034329 18 17 0,000 0,06705415 0,08968128 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,06705415 0,08961625 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,06705415 0,08955131 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,06705415 0,08948646 ! development of primary male sexual characteristics GO:0046546 17 17 0,000 0,06705415 0,08942171 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,06705415 0,08935705 ! neural crest cell development GO:0014032 19 17 0,000 0,06705415 0,08929249 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 18 17 0,000 0,06705415 0,08922802 ! negative regulation of cell development GO:0010721 18 17 0,000 0,06705415 0,08916364 GO:0050768|negative regulation of neurogenesis, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,06705415 0,08909936 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,06705415 0,08903516 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,06705415 0,08897106 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,06705415 0,08890705 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,06705415 0,08884314 ! pigmentation GO:0043473 17 17 0,000 0,06705415 0,08877931 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,06705415 0,08871558 ! adult locomotory behavior GO:0008344 17 17 0,000 0,06705415 0,08865194 ! embryonic organ development GO:0048568 17 17 0,000 0,06705415 0,08858839 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,06705415 0,08852493 ! liver development GO:0001889 17 17 0,000 0,06705415 0,08846156 ! gene silencing GO:0016458 17 17 0,000 0,06705415 0,08839829 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,07086043 0,09334937 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,07086043 0,0932827 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,07086043 0,09321611 ! meiosis I GO:0007127 18 18 0,000 0,07086043 0,09314963 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,07086043 0,09308323 ! membrane docking GO:0022406 18 18 0,000 0,07086043 0,09301693 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,07086043 0,09295073 ! mononuclear cell proliferation GO:0032943 18 18 0,000 0,07086043 0,09288462 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 0,000 0,07086043 0,0928186 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,07086043 0,09275268 ! cholesterol homeostasis GO:0042632 18 18 0,000 0,07086043 0,09268685 GO:0055092|sterol homeostasis, ! striated muscle contraction GO:0006941 18 18 0,000 0,07086043 0,09262112 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,07086043 0,09255548 GO:0006639|acylglycerol metabolic process, ! ceramide metabolic process GO:0006672 18 18 0,000 0,07086043 0,09248993 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,07086043 0,09242447 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,07086043 0,09235911 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,07086043 0,09229383 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,07086043 0,09222865 ! B cell differentiation GO:0030183 18 18 0,000 0,07086043 0,09216357 ! cellular response to extracellular stimulus GO:0031668 18 18 0,000 0,07086043 0,09209857 ! BMP signaling pathway GO:0030509 18 18 0,000 0,07086043 0,09203367 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,07086043 0,09196886 ! DNA damage checkpoint GO:0000077 19 19 0,000 0,07465173 0,09682135 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,07465173 0,09675327 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,07465173 0,09668527 GO:0006956|complement activation, ! negative regulation of DNA metabolic process GO:0051053 19 19 0,000 0,07465173 0,09661738 ! glial cell differentiation GO:0010001 19 19 0,000 0,07465173 0,09654957 ! regulation of pH GO:0006885 19 19 0,000 0,07465173 0,09648187 ! feeding behavior GO:0007631 19 19 0,000 0,07465173 0,09641426 ! peroxisome organization GO:0007031 19 19 0,000 0,07465173 0,09634674 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,07465173 0,09627932 ! regulation of striated muscle tissue development GO:0016202 20 19 0,000 0,07465173 0,09621199 ! metanephros development GO:0001656 19 19 0,000 0,07465173 0,09614475 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,07465173 0,09607761 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,07465173 0,09601057 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,07465173 0,09594361 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,07465173 0,09587675 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,07465173 0,09580999 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,07465173 0,09574331 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,07465173 0,09567673 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,07465173 0,09561025 ! eye morphogenesis GO:0048592 19 19 0,000 0,07465173 0,09554385 ! placenta development GO:0001890 19 19 0,000 0,07465173 0,09547755 ! response to heat GO:0009408 19 19 0,000 0,07465173 0,09541133 ! vesicle localization GO:0051648 20 19 0,000 0,07465173 0,09534521 ! regulation of muscle development GO:0048634 21 20 0,000 0,07842811 0,10009904 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,07842811 0,10002977 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,07842811 0,09996059 ! organic ether metabolic process GO:0018904 20 20 0,000 0,07842811 0,09989151 GO:0006662|glycerol ether metabolic process, ! neural tube development GO:0021915 21 20 0,000 0,07842811 0,09982252 ! nucleus organization GO:0006997 20 20 0,000 0,07842811 0,09975363 ! phagocytosis GO:0006909 21 20 0,000 0,07842811 0,09968484 ! positive regulation of gene-specific transcription GO:0043193 20 20 0,000 0,07842811 0,09961614 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,07842811 0,09954753 ! protein targeting to membrane GO:0006612 22 20 0,000 0,07842811 0,09947902 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,07842811 0,0994106 ! chromatin remodeling GO:0006338 20 20 0,000 0,07842811 0,09934228 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,07842811 0,09927405 ! lipid oxidation GO:0034440 20 20 0,000 0,07842811 0,09920591 GO:0019395|fatty acid oxidation, ! female gamete generation GO:0007292 20 20 0,000 0,07842811 0,09913787 ! negative regulation of neuron apoptosis GO:0043524 21 20 0,000 0,07842811 0,09906992 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,07842811 0,09900206 ! RNA modification GO:0009451 20 20 0,000 0,07842811 0,0989343 ! single fertilization GO:0007338 21 20 0,000 0,07842811 0,09886663 ! regulation of B cell activation GO:0050864 20 20 0,000 0,07842811 0,09879905 ! mitotic sister chromatid segregation GO:0000070 21 21 0,000 0,08218963 0,10346687 ! mRNA catabolic process GO:0006402 21 21 0,000 0,08218963 0,10339624 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,08218963 0,10332571 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,08218963 0,10325528 ! Notch signaling pathway GO:0007219 22 21 0,000 0,08218963 0,10318494 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,08218963 0,1031147 ! ear morphogenesis GO:0042471 21 21 0,000 0,08218963 0,10304455 ! organic anion transport GO:0015711 21 21 0,000 0,08218963 0,1029745 ! cholesterol transport GO:0030301 21 21 0,000 0,08218963 0,10290455 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,08218963 0,10283469 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,08218963 0,10276492 GO:0032313|regulation of Rab GTPase activity, ! DNA integrity checkpoint GO:0031570 21 21 0,000 0,08218963 0,10269525 ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,08218963 0,10262567 ! regulation of proteolysis GO:0030162 21 21 0,000 0,08218963 0,10255619 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,08218963 0,1024868 ! RNA export from nucleus GO:0006405 22 22 0,000 0,08593634 0,10708633 ! sister chromatid segregation GO:0000819 22 22 0,000 0,08593634 0,10701397 ! regulation of ion transport GO:0043269 22 22 0,000 0,08593634 0,10694171 ! odontogenesis GO:0042476 22 22 0,000 0,08593634 0,10686955 ! cell junction organization GO:0034330 23 22 0,000 0,08593634 0,10679749 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,08593634 0,10672553 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! hormone-mediated signaling GO:0009755 22 22 0,000 0,08593634 0,10665366 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,08593634 0,10658188 ! ovulation cycle process GO:0022602 22 22 0,000 0,08593634 0,10651021 ! spindle organization GO:0007051 22 22 0,000 0,08593634 0,10643863 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,08593634 0,10636715 ! cell chemotaxis GO:0060326 23 22 0,000 0,08593634 0,10629576 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,08593634 0,10622447 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,08593634 0,10615327 ! male sex differentiation GO:0046661 22 22 0,000 0,08593634 0,10608217 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,08593634 0,10601116 ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,08593634 0,10594025 ! detection of external stimulus GO:0009581 23 22 0,000 0,08593634 0,10586944 ! neuron migration GO:0001764 22 22 0,000 0,08593634 0,10579872 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,08593634 0,10572809 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,08593634 0,10565756 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,08593634 0,10558712 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,08593634 0,10551678 ! aerobic respiration GO:0009060 22 22 0,000 0,08593634 0,10544652 ! cytokine production GO:0001816 22 22 0,000 0,08593634 0,10537637 ! cytokinesis GO:0000910 23 22 0,000 0,08593634 0,1053063 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,08593634 0,10523633 ! response to hydrogen peroxide GO:0042542 24 23 0,000 0,0896683 0,10973352 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,0896683 0,1096607 ! viral infectious cycle GO:0019058 23 23 0,000 0,0896683 0,10958799 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,0896683 0,10951536 ! response to estrogen stimulus GO:0043627 23 23 0,000 0,0896683 0,10944284 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,0896683 0,1093704 ! mitotic cell cycle checkpoint GO:0007093 24 23 0,000 0,0896683 0,10929807 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,0896683 0,10922583 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,0896683 0,10915369 ! endocrine system development GO:0035270 23 23 0,000 0,0896683 0,10908164 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,0896683 0,10900968 ! female gonad development GO:0008585 23 23 0,000 0,0896683 0,10893783 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,0896683 0,10886606 ! lipid homeostasis GO:0055088 23 23 0,000 0,0896683 0,10879439 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,0896683 0,10872282 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,0896683 0,10865134 ! mitochondrial transport GO:0006839 24 24 0,000 0,09338557 0,11308121 ! gliogenesis GO:0042063 24 24 0,000 0,09338557 0,11300696 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,09338557 0,11293281 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,09338557 0,11285876 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,09338557 0,1127848 ! T cell differentiation GO:0030217 24 24 0,000 0,09338557 0,11271094 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,09338557 0,11263717 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,09338557 0,11256351 ! ovulation cycle GO:0042698 24 24 0,000 0,09338557 0,11248994 ! fertilization GO:0009566 25 24 0,000 0,09338557 0,11241646 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,09338557 0,11234308 ! androgen receptor signaling pathway GO:0030521 24 24 0,000 0,09338557 0,1122698 ! epithelial tube morphogenesis GO:0060562 25 24 0,000 0,09338557 0,11219661 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,09708819 0,11656908 ! negative regulation of secretion GO:0051048 26 25 0,000 0,09708819 0,11649319 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,09708819 0,1164174 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,09708819 0,1163417 ! cellular component disassembly GO:0022411 26 25 0,000 0,09708819 0,11626611 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,09708819 0,11619061 ! development of primary female sexual characteristics GO:0046545 25 25 0,000 0,09708819 0,11611521 GO:0046660|female sex differentiation, ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,09708819 0,11603991 ! excretion GO:0007588 25 25 0,000 0,09708819 0,11596471 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,09708819 0,1158896 ! gastrulation GO:0007369 25 25 0,000 0,09708819 0,11581459 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,09708819 0,11573968 ! regulation of endocytosis GO:0030100 25 25 0,000 0,09708819 0,11566486 ! glycolysis GO:0006096 26 26 0,000 0,10077624 0,11998101 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,10077624 0,11990355 ! cellular defense response GO:0006968 26 26 0,000 0,10077624 0,1198262 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,10077624 0,11974894 ! double-strand break repair GO:0006302 27 26 0,000 0,10077624 0,11967178 ! regulation of protein secretion GO:0050708 26 26 0,000 0,10077624 0,11959472 ! germ cell development GO:0007281 27 26 0,000 0,10077624 0,11951776 ! pigment metabolic process GO:0042440 26 26 0,000 0,10077624 0,1194409 ! chloride transport GO:0006821 27 27 0,000 0,10444975 0,12371522 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,10444975 0,12363577 ! learning or memory GO:0007611 28 27 0,000 0,10444975 0,12355641 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,10444975 0,12347716 ! peptide metabolic process GO:0006518 29 27 0,000 0,10444975 0,12339801 ! activation of caspase activity GO:0006919 27 27 0,000 0,10444975 0,12331896 ! mesenchymal cell development GO:0014031 29 27 0,000 0,10444975 0,12324001 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! inner ear development GO:0048839 27 27 0,000 0,10444975 0,12316116 ! defense response to bacterium GO:0042742 27 27 0,000 0,10444975 0,12308241 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,10444975 0,12300376 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,10444975 0,12292522 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,10810879 0,12715029 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,10810879 0,1270692 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,10810879 0,12698821 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,10810879 0,12690733 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,10810879 0,12682655 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,10810879 0,12674587 ! histone modification GO:0016570 28 28 0,000 0,10810879 0,12666529 ! developmental growth GO:0048589 28 28 0,000 0,10810879 0,12658482 ! cartilage development GO:0051216 29 28 0,000 0,10810879 0,12650445 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,11175341 0,13068626 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,11175341 0,13060339 ! leukocyte migration GO:0050900 30 29 0,000 0,11175341 0,13052062 ! branching morphogenesis of a tube GO:0048754 29 29 0,000 0,11175341 0,13043796 ! antigen processing and presentation GO:0019882 29 29 0,000 0,11175341 0,13035541 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,11175341 0,13027295 ! tRNA processing GO:0008033 29 29 0,000 0,11175341 0,13019061 ! covalent chromatin modification GO:0016569 29 29 0,000 0,11175341 0,13010836 ! adult behavior GO:0030534 30 29 0,000 0,11175341 0,13002623 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,11175341 0,12994419 ! transition metal ion transport GO:0000041 31 30 0,000 0,11538367 0,13408077 ! RNA catabolic process GO:0006401 30 30 0,000 0,11538367 0,13399629 ! response to reactive oxygen species GO:0000302 31 30 0,000 0,11538367 0,13391191 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,11538367 0,13382763 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,11538367 0,13374346 GO:0043280|positive regulation of caspase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,11538367 0,1336594 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,11538367 0,13357545 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,11538367 0,13349159 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,11538367 0,13340785 ! response to temperature stimulus GO:0009266 30 30 0,000 0,11538367 0,13332421 ! regulation of ossification GO:0030278 30 30 0,000 0,11538367 0,13324067 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,11538367 0,13315724 GO:0019724|B cell mediated immunity, ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,11538367 0,13307391 ! vesicle organization GO:0016050 30 30 0,000 0,11538367 0,13299069 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,11538367 0,13290757 ! establishment of organelle localization GO:0051656 31 30 0,000 0,11538367 0,13282455 ! regulation of translational initiation GO:0006446 31 31 0,000 0,11899962 0,13690156 ! membrane fusion GO:0006944 31 31 0,000 0,11899962 0,13681616 ! B cell activation GO:0042113 31 31 0,000 0,11899962 0,13673086 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,11899962 0,13664567 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,11899962 0,13656059 ! ion transmembrane transport GO:0034220 31 31 0,000 0,11899962 0,13647561 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! aging GO:0007568 32 31 0,000 0,11899962 0,13639074 ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,11899962 0,13630597 ! digestion GO:0007586 31 31 0,000 0,11899962 0,13622131 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,11899962 0,13613675 ! regulation of heart contraction GO:0008016 31 31 0,000 0,11899962 0,1360523 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,11899962 0,13596795 ! camera-type eye development GO:0043010 31 31 0,000 0,11899962 0,13588371 ! extracellular matrix organization GO:0030198 31 31 0,000 0,11899962 0,13579957 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,11899962 0,13571554 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,11899962 0,1356316 ! negative regulation of cell growth GO:0030308 32 32 0,000 0,12260132 0,13965033 ! glucose catabolic process GO:0006007 32 32 0,000 0,12260132 0,13956407 ! lipid modification GO:0030258 32 32 0,000 0,12260132 0,13947792 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,12260132 0,13939187 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,12260132 0,13930594 ! cell maturation GO:0048469 32 32 0,000 0,12260132 0,1392201 ! morphogenesis of a branching structure GO:0001763 32 32 0,000 0,12260132 0,13913438 ! nuclear export GO:0051168 32 32 0,000 0,12260132 0,13904876 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,12260132 0,13896324 ! negative regulation of cell size GO:0045792 33 33 0,000 0,12618881 0,1429416 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,12618881 0,1428538 ! amino acid transport GO:0006865 33 33 0,000 0,12618881 0,1427661 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,12618881 0,14267852 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,12618881 0,14259104 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,12618881 0,14250367 ! regulation of neuron differentiation GO:0045664 34 33 0,000 0,12618881 0,1424164 ! regulation of neuron apoptosis GO:0043523 34 33 0,000 0,12618881 0,14232924 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,12618881 0,14224219 ! regulation of actin filament length GO:0030832 34 34 0,000 0,12976216 0,14618072 ! response to metal ion GO:0010038 34 34 0,000 0,12976216 0,14609142 ! ear development GO:0043583 34 34 0,000 0,12976216 0,14600224 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,12976216 0,14591316 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,12976216 0,14582418 ! secondary metabolic process GO:0019748 34 34 0,000 0,12976216 0,14573532 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,12976216 0,14564657 ! detection of stimulus GO:0051606 36 34 0,000 0,12976216 0,14555792 ! acute inflammatory response GO:0002526 35 35 0,000 0,13332142 0,14945947 ! regulation of cellular component size GO:0032535 35 35 0,000 0,13332142 0,14936861 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,13332142 0,14927787 ! mesoderm development GO:0007498 35 35 0,000 0,13332142 0,14918723 ! multicellular organism reproduction GO:0032504 36 35 0,000 0,13332142 0,1490967 GO:0048609|reproductive process in a multicellular organism, ! inorganic anion transport GO:0015698 35 35 0,000 0,13332142 0,14900629 ! response to steroid hormone stimulus GO:0048545 35 35 0,000 0,13332142 0,14891598 ! regulation of immune effector process GO:0002697 35 35 0,000 0,13332142 0,14882578 ! hydrogen transport GO:0006818 36 36 0,000 0,13686663 0,1526908 GO:0015992|proton transport, ! response to inorganic substance GO:0010035 36 36 0,000 0,13686663 0,15259843 ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,13686663 0,15250617 ! regulation of mitosis GO:0007088 37 36 0,000 0,13686663 0,15241402 GO:0051783|regulation of nuclear division, ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,13686663 0,15232198 GO:0035113|embryonic appendage morphogenesis, ! female pregnancy GO:0007565 37 36 0,000 0,13686663 0,15223005 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,13686663 0,15213824 ! positive regulation of organelle organization GO:0010638 36 36 0,000 0,13686663 0,15204653 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,13686663 0,15195494 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,13686663 0,15186346 ! gonad development GO:0008406 36 36 0,000 0,13686663 0,15177208 ! activation of immune response GO:0002253 36 36 0,000 0,13686663 0,15168082 ! meiosis GO:0007126 37 37 0,000 0,14039786 0,15550076 GO:0051327|M phase of meiotic cell cycle, ! response to drug GO:0042493 37 37 0,000 0,14039786 0,15540736 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,14039786 0,15531408 ! eye development GO:0001654 37 37 0,000 0,14039786 0,15522091 ! negative regulation of growth GO:0045926 37 37 0,000 0,14039786 0,15512785 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,14039786 0,15503491 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,14039786 0,15494207 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,14039786 0,15484935 ! positive regulation of secretion GO:0051047 39 38 0,000 0,14391516 0,15863375 ! neurotransmitter transport GO:0006836 40 38 0,000 0,14391516 0,15853893 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,14391516 0,15844423 ! exocytosis GO:0006887 40 38 0,000 0,14391516 0,15834963 ! chromosome segregation GO:0007059 38 38 0,000 0,14391516 0,15825515 ! hexose catabolic process GO:0019320 38 38 0,000 0,14391516 0,15816078 ! RNA elongation GO:0006354 38 38 0,000 0,14391516 0,15806653 ! meiotic cell cycle GO:0051321 38 38 0,000 0,14391516 0,15797238 ! regulation of neurological system process GO:0031644 38 38 0,000 0,14391516 0,15787835 ! response to unfolded protein GO:0006986 39 39 0,000 0,14741857 0,16162548 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,14741857 0,16152939 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,14741857 0,16143341 ! nucleotide-excision repair GO:0006289 40 39 0,000 0,14741857 0,16133755 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,14741857 0,1612418 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,14741857 0,16114616 ! regulation of MAPKKK cascade GO:0043408 41 39 0,000 0,14741857 0,16105064 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,14741857 0,16095523 ! developmental maturation GO:0021700 39 39 0,000 0,14741857 0,16085994 ! lymphocyte differentiation GO:0030098 39 39 0,000 0,14741857 0,16076475 ! limb development GO:0060173 39 39 0,000 0,14741857 0,16066968 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! DNA catabolic process GO:0006308 41 40 0,000 0,15090816 0,16437574 ! organelle localization GO:0051640 41 40 0,000 0,15090816 0,16427864 ! cell cycle checkpoint GO:0000075 42 41 0,000 0,15438398 0,16796321 ! amine catabolic process GO:0009310 42 41 0,000 0,15438398 0,16786411 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,15438398 0,16776514 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,15438398 0,16766628 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,15438398 0,16756753 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,15438398 0,16746891 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,15438398 0,16737039 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,15784607 0,17102311 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,15784607 0,17092262 ! development of primary sexual characteristics GO:0045137 42 42 0,000 0,15784607 0,17082226 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,15784607 0,17072201 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! response to protein stimulus GO:0051789 42 42 0,000 0,15784607 0,17062188 ! forebrain development GO:0030900 43 42 0,000 0,15784607 0,17052187 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,15784607 0,17042197 ! reproductive structure development GO:0048608 43 43 0,000 0,16129449 0,17404318 ! alcohol catabolic process GO:0046164 43 43 0,000 0,16129449 0,17394134 ! homeostasis of number of cells GO:0048872 44 43 0,000 0,16129449 0,17383962 ! humoral immune response GO:0006959 44 44 0,000 0,1647293 0,17743781 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 0,000 0,1647293 0,17733417 ! mRNA transport GO:0051028 44 44 0,000 0,1647293 0,17723064 ! protein import into nucleus GO:0006606 44 44 0,000 0,1647293 0,17712724 ! negative regulation of organelle organization GO:0010639 45 44 0,000 0,1647293 0,17702396 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,1647293 0,1769208 ! amine biosynthetic process GO:0009309 46 45 0,000 0,16815053 0,18049006 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,16815053 0,180385 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,16815053 0,18028007 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 0,000 0,16815053 0,18017525 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,16815053 0,18007056 ! nuclear import GO:0051170 45 45 0,000 0,16815053 0,17996599 ! protein processing GO:0016485 45 45 0,000 0,16815053 0,17986154 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,17155826 0,18340015 ! tube morphogenesis GO:0035239 47 46 0,000 0,17155826 0,18329383 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 0,000 0,17155826 0,18318764 ! positive regulation of ligase activity GO:0051351 47 46 0,000 0,17155826 0,18308157 ! sex differentiation GO:0007548 47 47 0,000 0,17495252 0,18659577 ! amine transport GO:0015837 47 47 0,000 0,17495252 0,18648785 ! rhythmic process GO:0048511 47 47 0,000 0,17495252 0,18638005 ! calcium ion transport GO:0006816 48 48 0,000 0,17833336 0,18987197 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 0,000 0,17833336 0,18976235 ! regulation of cell cycle process GO:0010564 50 48 0,000 0,17833336 0,18965285 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,17833336 0,18954348 ! protein localization in nucleus GO:0034504 48 48 0,000 0,17833336 0,18943423 ! leukocyte differentiation GO:0002521 50 49 0,000 0,18170085 0,19290015 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,18170085 0,1927891 ! divalent metal ion transport GO:0070838 49 49 0,000 0,18170085 0,19267817 ! response to bacterium GO:0009617 50 49 0,000 0,18170085 0,19256737 ! regulation of ligase activity GO:0051340 50 49 0,000 0,18170085 0,1924567 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,18170085 0,19234616 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,18170085 0,19223574 GO:0002696|positive regulation of leukocyte activation, ! chromatin assembly GO:0031497 50 50 0,000 0,18505502 0,19567207 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,18505502 0,19555987 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! T cell activation GO:0042110 51 50 0,000 0,18505502 0,1954478 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,18505502 0,19533586 ! regulation of neurogenesis GO:0050767 51 50 0,000 0,18505502 0,19522405 ! anterior/posterior pattern formation GO:0009952 51 50 0,000 0,18505502 0,19511236 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,18839594 0,19852128 ! positive regulation of immune response GO:0050778 51 51 0,000 0,18839594 0,19840784 ! rRNA metabolic process GO:0016072 51 51 0,000 0,18839594 0,19829453 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,18839594 0,19818135 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,18839594 0,19806829 ! protein maturation GO:0051604 51 51 0,000 0,18839594 0,19795537 ! RNA localization GO:0006403 52 52 0,000 0,19172365 0,20133714 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,19172365 0,20122249 ! sodium ion transport GO:0006814 53 53 0,000 0,1950382 0,20458475 ! tRNA metabolic process GO:0006399 53 53 0,000 0,1950382 0,20446837 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,1950382 0,20435213 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,1950382 0,20423602 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,1950382 0,20412004 ! response to virus GO:0009615 54 54 0,000 0,19833964 0,20745741 ! hormone metabolic process GO:0042445 55 54 0,000 0,19833964 0,20733973 ! nucleosome organization GO:0034728 55 55 0,000 0,20162802 0,21065784 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,20162802 0,21053849 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,20490339 0,21383746 ! regulation of nervous system development GO:0051960 57 56 0,000 0,20490339 0,21371644 ! ATP metabolic process GO:0046034 57 57 0,000 0,2081658 0,21699637 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,2081658 0,2168737 ! innate immune response GO:0045087 58 58 0,000 0,21141531 0,22013469 ! carboxylic acid transport GO:0046942 59 59 0,000 0,21465195 0,22337862 GO:0015849|organic acid transport, ! regulation of cell development GO:0060284 60 59 0,000 0,21465195 0,22325256 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,21465195 0,22312664 ! protein localization in organelle GO:0033365 59 59 0,000 0,21465195 0,22300087 ! immune effector process GO:0002252 59 59 0,000 0,21465195 0,22287523 ! potassium ion transport GO:0006813 60 60 0,000 0,21787578 0,22609519 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 0,000 0,21787578 0,22596796 ! cellular respiration GO:0045333 62 61 0,000 0,22108685 0,22916932 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,22108685 0,2290405 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,22108685 0,22891183 GO:0016054|organic acid catabolic process, ! lipid transport GO:0006869 62 62 0,000 0,2242852 0,23209299 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,2242852 0,23196275 ! morphogenesis of an epithelium GO:0002009 63 62 0,000 0,2242852 0,23183265 GO:0060429|epithelium development, ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,2242852 0,2317027 ! protein import GO:0017038 62 62 0,000 0,2242852 0,2315729 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,2242852 0,23144324 ! negative regulation of cellular component organization GO:0051129 65 63 0,000 0,22747089 0,23459924 ! glucose metabolic process GO:0006006 63 63 0,000 0,22747089 0,23446803 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,22747089 0,23433697 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,22747089 0,23420606 ! glycerolipid metabolic process GO:0046486 65 64 0,000 0,23064395 0,23734049 ! anion transport GO:0006820 65 65 0,000 0,23380446 0,24045849 ! positive regulation of cellular component organization GO:0051130 65 65 0,000 0,23380446 0,24032438 ! regulation of hormone levels GO:0010817 66 65 0,000 0,23380446 0,24019042 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,23695243 0,24328877 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,23695243 0,2431533 ! DNA packaging GO:0006323 66 66 0,000 0,23695243 0,24301799 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,24008794 0,24609681 ! muscle contraction GO:0006936 67 67 0,000 0,24008794 0,24596002 ! negative regulation of cell differentiation GO:0045596 68 67 0,000 0,24008794 0,24582337 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,24008794 0,24568688 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,24321102 0,24874468 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,24321102 0,24860671 ! regulation of translation GO:0006417 69 69 0,000 0,24632172 0,25164686 ! sensory perception of sound GO:0007605 71 69 0,000 0,24632172 0,25150744 GO:0050954|sensory perception of mechanical stimulus, ! regionalization GO:0003002 70 69 0,000 0,24632172 0,25136818 ! regulation of mitotic cell cycle GO:0007346 72 69 0,000 0,24632172 0,25122907 ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,24942009 0,25424846 GO:0016053|organic acid biosynthetic process, ! translational elongation GO:0006414 71 71 0,000 0,25250617 0,257252 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,25250617 0,25710988 ! calcium ion homeostasis GO:0055074 71 71 0,000 0,25250617 0,2569679 GO:0006874|cellular calcium ion homeostasis, ! ribosome biogenesis GO:0042254 71 71 0,000 0,25250617 0,25682609 ! secretion by cell GO:0032940 75 72 0,000 0,25558002 0,25980914 ! sensory organ development GO:0007423 72 72 0,000 0,25558002 0,25966592 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,26169119 0,2657283 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,2647286 0,26866455 ! response to oxidative stress GO:0006979 76 75 0,000 0,2647286 0,26851669 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,2647286 0,26836899 ! cellular metal ion homeostasis GO:0006875 77 77 0,000 0,27076733 0,27433985 ! metal ion homeostasis GO:0055065 78 78 0,000 0,27376872 0,27722844 ! regulation of immune response GO:0050776 78 78 0,000 0,27376872 0,2770762 ! nuclear transport GO:0051169 79 79 0,000 0,27675821 0,27994807 GO:0006913|nucleocytoplasmic transport, ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,27973583 0,28280479 ! lymphocyte activation GO:0046649 82 81 0,000 0,28270162 0,28564643 ! lipid catabolic process GO:0016042 82 81 0,000 0,28270162 0,28548991 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,28859792 0,29128476 ! ncRNA processing GO:0034470 83 83 0,000 0,28859792 0,29112532 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,29444747 0,29686361 ! positive regulation of cell differentiation GO:0045597 87 85 0,000 0,29444747 0,2967013 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,29735482 0,29946718 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 0,000 0,29735482 0,29930362 ! male gamete generation GO:0048232 90 88 0,000 0,30313491 0,30495504 GO:0007283|spermatogenesis, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,30313491 0,30478868 ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 0,000 0,30600774 0,30750941 ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,30886914 0,31021571 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 0,000 0,31171916 0,31290763 ! visual perception GO:0007601 93 92 0,000 0,31455785 0,31558526 GO:0050953|sensory perception of light stimulus, ! pattern specification process GO:0007389 96 94 0,000 0,3202014 0,32107246 ! cofactor metabolic process GO:0051186 95 94 0,000 0,3202014 0,32089787 ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,33135438 0,33189463 ! anti-apoptosis GO:0006916 100 99 0,000 0,33411494 0,33447791 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 0,000 0,3368645 0,33704738 ! response to other organism GO:0051707 101 100 0,000 0,3368645 0,3368645