pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6660-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! protein amino acid autophosphorylation GO:0046777 80 45 7,000 2,05E-11 4,715E-08 ! positive regulation of cell migration GO:0030335 92 51 6,000 2,644E-09 3,041E-06 ! positive regulation of cell motion GO:0051272 99 56 6,000 5,203E-09 3,989E-06 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 6,000 1,211E-08 6,962E-06 ! positive regulation of endothelial cell migration GO:0010595 18 8 3,000 2,532E-08 1,165E-05 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 7,544E-08 2,892E-05 ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 9,988E-08 3,282E-05 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 2,000 8,49E-07 2,441E-04 ! regulation of endothelial cell migration GO:0010594 40 19 3,000 1,351E-06 3,452E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 1,693E-06 3,893E-04 ! protein heterooligomerization GO:0051291 10 7 2,000 2,952E-06 6,173E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 3,641E-06 6,978E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 4,709E-06 8,331E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 4,709E-06 7,736E-04 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 2,000 7,04E-06 1,079E-03 ! blood vessel remodeling GO:0001974 21 10 2,000 1,003E-05 1,441E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 1,374E-05 1,859E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 1,498E-05 1,915E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 1,536E-05 1,859E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 1,72E-05 1,978E-03 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of intracellular protein transport GO:0033157 59 35 3,000 1,728E-05 1,893E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 2,000 1,826E-05 1,909E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 1,967E-05 1,967E-03 ! regulation of protein transport GO:0051223 114 76 4,000 2,24E-05 2,147E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 2,679E-05 2,464E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 2,966E-05 2,624E-03 ! negative regulation of blood coagulation GO:0030195 19 14 2,000 3,002E-05 2,557E-03 ! glucose transport GO:0015758 52 41 3,000 3,276E-05 2,691E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 3,608E-05 2,862E-03 ! hexose transport GO:0008645 54 42 3,000 3,608E-05 2,766E-03 GO:0015749|monosaccharide transport, ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 2,000 3,74E-05 2,775E-03 ! regulation of protein localization GO:0032880 132 85 4,000 3,855E-05 2,771E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 3,965E-05 2,763E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 4,755E-05 3,216E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 5,554E-05 3,65E-03 ! negative regulation of coagulation GO:0050819 23 17 2,000 5,554E-05 3,549E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 5,554E-05 3,453E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 6,147E-05 3,72E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 6,644E-05 3,918E-03 ! regulation of intracellular transport GO:0032386 78 49 3,000 6,671E-05 3,836E-03 ! regulation of response to external stimulus GO:0032101 139 96 4,000 6,914E-05 3,879E-03 ! positive regulation of growth GO:0045927 67 50 3,000 7,226E-05 3,957E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 7,864E-05 4,206E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 7,864E-05 4,111E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 7,864E-05 4,019E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 9,222E-05 4,611E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 9,222E-05 4,513E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 2,000 1,072E-04 5,139E-03 ! carbohydrate transport GO:0008643 74 57 3,000 1,21E-04 5,682E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,21E-04 5,568E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 1,238E-04 5,582E-03 ! regulation of behavior GO:0050795 38 22 2,000 1,238E-04 5,475E-03 ! regulation of blood coagulation GO:0030193 34 22 2,000 1,238E-04 5,372E-03 ! activation of MAPK activity GO:0000187 84 59 3,000 1,385E-04 5,9E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 1,419E-04 5,934E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 1,419E-04 5,828E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 1,616E-04 6,523E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 1,616E-04 6,41E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 1,616E-04 6,301E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 1,831E-04 7,019E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,948E-04 7,346E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 1,948E-04 7,227E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,948E-04 7,113E-03 ! valine metabolic process GO:0006573 8 5 1,000 1,948E-04 7,002E-03 ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 1,000 1,948E-04 6,894E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 1,948E-04 6,789E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 1,948E-04 6,688E-03 ! centrosome duplication GO:0051298 5 5 1,000 1,948E-04 6,59E-03 ! response to UV-C GO:0010225 6 5 1,000 1,948E-04 6,494E-03 ! muscle cell proliferation GO:0033002 8 5 1,000 1,948E-04 6,401E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,948E-04 6,311E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 2,063E-04 6,591E-03 ! regulation of coagulation GO:0050818 39 26 2,000 2,063E-04 6,5E-03 ! negative regulation of protein transport GO:0051224 49 27 2,000 2,314E-04 7,191E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 2,583E-04 7,921E-03 ! regulation of catabolic process GO:0009894 106 70 3,000 2,689E-04 8,138E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 2,914E-04 8,704E-03 ! male meiosis GO:0007140 7 6 1,000 2,914E-04 8,592E-03 ! mRNA stabilization GO:0048255 15 6 1,000 2,914E-04 8,484E-03 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 2,914E-04 8,378E-03 GO:0031958|corticosteroid receptor signaling pathway, ! cGMP-mediated signaling GO:0019934 10 6 1,000 2,914E-04 8,274E-03 ! ER overload response GO:0006983 7 6 1,000 2,914E-04 8,173E-03 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 2,914E-04 8,075E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! male sex determination GO:0030238 9 6 1,000 2,914E-04 7,979E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 2,914E-04 7,885E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 1,000 2,914E-04 7,793E-03 ! blastocyst growth GO:0001832 15 6 1,000 2,914E-04 7,703E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 2,914E-04 7,616E-03 ! response to hypoxia GO:0001666 132 72 3,000 2,997E-04 7,745E-03 ! negative regulation of transport GO:0051051 116 73 3,000 3,16E-04 8,076E-03 ! negative regulation of cell activation GO:0050866 44 30 2,000 3,181E-04 8,039E-03 ! response to oxygen levels GO:0070482 137 74 3,000 3,33E-04 8,324E-03 ! mammary gland development GO:0030879 57 31 2,000 3,51E-04 8,681E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 4,068E-04 9,953E-03 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 4,068E-04 9,848E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 4,068E-04 9,746E-03 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 4,068E-04 9,645E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 4,068E-04 9,547E-03 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 4,068E-04 9,45E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 4,068E-04 9,356E-03 ! cardiac muscle cell differentiation GO:0055007 12 7 1,000 4,068E-04 9,263E-03 ! fibrinolysis GO:0042730 9 7 1,000 4,068E-04 9,172E-03 ! muscle adaptation GO:0043500 12 7 1,000 4,068E-04 9,083E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 4,233E-04 9,362E-03 ! induction of positive chemotaxis GO:0050930 14 8 1,000 5,408E-04 0,01184586 ! succinate metabolic process GO:0006105 14 8 1,000 5,408E-04 0,01173411 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 5,408E-04 0,01162444 ! keratinocyte proliferation GO:0043616 12 8 1,000 5,408E-04 0,01151681 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 5,408E-04 0,01141115 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 1,000 5,408E-04 0,01130741 ! regulation of vascular permeability GO:0043114 12 8 1,000 5,408E-04 0,01120555 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 5,408E-04 0,0111055 ! induction of an organ GO:0001759 11 8 1,000 5,408E-04 0,01100722 ! regulation of embryonic development GO:0045995 16 8 1,000 5,408E-04 0,01091066 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 5,408E-04 0,01081579 ! tissue remodeling GO:0048771 62 36 2,000 5,487E-04 0,01087926 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 5,646E-04 0,01109886 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 5,646E-04 0,0110048 ! regulation of developmental growth GO:0048638 13 9 1,000 6,933E-04 0,01339971 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 6,933E-04 0,01328804 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 6,933E-04 0,01317822 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 1,000 6,933E-04 0,0130702 ! lung alveolus development GO:0048286 17 9 1,000 6,933E-04 0,01296394 ! phosphagen metabolic process GO:0006599 12 9 1,000 6,933E-04 0,01285939 GO:0006600|creatine metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 1,000 6,933E-04 0,01275652 ! substrate-bound cell migration GO:0006929 10 9 1,000 6,933E-04 0,01265528 ! receptor clustering GO:0043113 15 9 1,000 6,933E-04 0,01255563 ! motor axon guidance GO:0008045 14 9 1,000 6,933E-04 0,01245754 ! oocyte differentiation GO:0009994 12 9 1,000 6,933E-04 0,01236097 GO:0048599|oocyte development, ! regulation of muscle adaptation GO:0043502 12 9 1,000 6,933E-04 0,01226588 ! localization within membrane GO:0051668 15 9 1,000 6,933E-04 0,01217225 ! cell growth GO:0016049 61 39 2,000 6,956E-04 0,01212017 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 7,496E-04 0,01296278 ! positive regulation of protein transport GO:0051222 55 40 2,000 7,496E-04 0,01286605 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 7,925E-04 0,01350226 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 8,641E-04 0,01461354 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 8,641E-04 0,01450687 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 8,641E-04 0,01440175 ! response to X-ray GO:0010165 16 10 1,000 8,641E-04 0,01429814 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 8,641E-04 0,01419601 ! regulation of bone resorption GO:0045124 24 10 1,000 8,641E-04 0,01409533 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 8,641E-04 0,01399607 ! nitric oxide mediated signal transduction GO:0007263 17 10 1,000 8,641E-04 0,01389819 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 8,641E-04 0,01380168 GO:0043470|regulation of carbohydrate catabolic process, ! cardiac cell differentiation GO:0035051 16 10 1,000 8,641E-04 0,0137065 ! developmental induction GO:0031128 13 10 1,000 8,641E-04 0,01361262 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 8,641E-04 0,01352001 ! regulation of gene expression, epigenetic GO:0040029 72 42 2,000 8,654E-04 0,01344905 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 9,273E-04 0,01431479 ! virus-host interaction GO:0019048 17 11 1,000 1,053E-03 0,01614715 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,053E-03 0,01604022 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 1,053E-03 0,01593469 GO:0000725|recombinational repair, ! regulation of positive chemotaxis GO:0050926 17 11 1,000 1,053E-03 0,01583054 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 1,053E-03 0,01572775 ! regulation of mRNA processing GO:0050684 18 11 1,000 1,053E-03 0,01562628 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 1,053E-03 0,01552611 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 1,053E-03 0,01542722 ! chromatin silencing GO:0006342 19 11 1,000 1,053E-03 0,01532957 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,053E-03 0,01523316 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,053E-03 0,01513795 GO:0042130|negative regulation of T cell proliferation, ! vascular process in circulatory system GO:0003018 69 45 2,000 1,059E-03 0,01513552 ! response to UV GO:0009411 75 46 2,000 1,13E-03 0,01604014 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,26E-03 0,01777968 ! positive regulation of cell growth GO:0030307 16 12 1,000 1,26E-03 0,01767126 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,26E-03 0,01756416 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,26E-03 0,01745836 ! response to gamma radiation GO:0010332 20 12 1,000 1,26E-03 0,01735382 ! regulation of mRNA stability GO:0043488 27 12 1,000 1,26E-03 0,01725052 ! heart morphogenesis GO:0003007 65 48 2,000 1,279E-03 0,01740731 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 1,279E-03 0,01730492 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 1,358E-03 0,01826719 ! intermediate filament cytoskeleton organization GO:0045104 23 13 1,000 1,485E-03 0,01985533 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,485E-03 0,01974056 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,485E-03 0,01962711 ! regulation of RNA stability GO:0043487 28 13 1,000 1,485E-03 0,01951495 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,525E-03 0,0199333 ! activation of phospholipase C activity GO:0007202 87 51 2,000 1,525E-03 0,01982068 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 2,000 1,525E-03 0,01970933 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 1,614E-03 0,0207328 ! regulation of S phase GO:0033261 18 14 1,000 1,727E-03 0,02207108 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 1,727E-03 0,02194914 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,727E-03 0,02182854 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 1,727E-03 0,02170926 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 1,000 1,727E-03 0,02159128 ! activation of MAPKK activity GO:0000186 21 14 1,000 1,727E-03 0,02147457 ! negative regulation of caspase activity GO:0043154 20 14 1,000 1,727E-03 0,02135911 ! intermediate filament-based process GO:0045103 24 14 1,000 1,727E-03 0,02124489 ! axon cargo transport GO:0008088 27 14 1,000 1,727E-03 0,02113189 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,727E-03 0,02102008 ! regulation of phospholipase activity GO:0010517 90 54 2,000 1,799E-03 0,02178267 ! positive regulation of lipase activity GO:0060193 90 54 2,000 1,799E-03 0,02166863 ! positive regulation of cell size GO:0045793 20 15 1,000 1,987E-03 0,02380603 ! skin development GO:0043588 25 15 1,000 1,987E-03 0,02368269 ! lipid phosphorylation GO:0046834 23 15 1,000 1,987E-03 0,02356061 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 1,987E-03 0,02343979 ! centrosome cycle GO:0007098 16 15 1,000 1,987E-03 0,0233202 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 1,987E-03 0,02320182 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 1,987E-03 0,02308464 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,987E-03 0,02296863 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,987E-03 0,02285379 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! DNA damage response, signal transduction GO:0042770 96 56 2,000 1,998E-03 0,02286471 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,265E-03 0,02578538 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,265E-03 0,02565835 ! oogenesis GO:0048477 23 16 1,000 2,265E-03 0,02553258 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 2,265E-03 0,02540803 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,265E-03 0,02528469 ! lung development GO:0030324 94 59 2,000 2,321E-03 0,02578944 ! regulation of homeostatic process GO:0032844 105 60 2,000 2,435E-03 0,02693017 ! signal complex assembly GO:0007172 29 17 1,000 2,559E-03 0,02816315 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 2,559E-03 0,02802904 ! neuromuscular junction development GO:0007528 23 17 1,000 2,559E-03 0,0278962 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 2,559E-03 0,02776462 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 1,000 2,559E-03 0,02763427 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 2,559E-03 0,02750513 ! peptidyl-serine modification GO:0018209 27 17 1,000 2,559E-03 0,0273772 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 2,559E-03 0,02725046 ! respiratory tube development GO:0030323 99 62 2,000 2,675E-03 0,02834737 ! regulation of transcription factor activity GO:0051090 97 63 2,000 2,799E-03 0,02953384 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 2,799E-03 0,02939898 ! regulation of lipase activity GO:0060191 109 63 2,000 2,799E-03 0,02926535 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 2,871E-03 0,02987674 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 2,871E-03 0,02974216 GO:0050886|endocrine process, ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,871E-03 0,02960879 ! response to retinoic acid GO:0032526 25 18 1,000 2,871E-03 0,02947661 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 2,871E-03 0,0293456 ! estrogen receptor signaling pathway GO:0030520 30 18 1,000 2,871E-03 0,02921575 ! negative regulation of T cell activation GO:0050868 25 18 1,000 2,871E-03 0,02908705 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 2,928E-03 0,02953293 ! respiratory system development GO:0060541 100 64 2,000 2,928E-03 0,02940397 ! protein oligomerization GO:0051259 100 65 2,000 3,059E-03 0,030595 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 3,199E-03 0,03185401 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 3,199E-03 0,03171671 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 3,199E-03 0,03158058 ! response to vitamin A GO:0033189 26 19 1,000 3,199E-03 0,03144562 ! sex determination GO:0007530 29 19 1,000 3,199E-03 0,03131181 ! renal system process GO:0003014 35 19 1,000 3,199E-03 0,03117914 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 3,199E-03 0,03104758 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 3,199E-03 0,03091713 ! protein stabilization GO:0050821 26 19 1,000 3,199E-03 0,03078777 ! microtubule-based transport GO:0010970 37 20 1,000 3,544E-03 0,03396789 ! response to vitamin GO:0033273 29 20 1,000 3,544E-03 0,03382695 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 3,544E-03 0,03368717 ! activation of protein kinase activity GO:0032147 102 69 2,000 3,623E-03 0,03429525 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 3,906E-03 0,03682158 ! protein amino acid acylation GO:0043543 37 21 1,000 3,906E-03 0,03667128 ! cell aging GO:0007569 32 21 1,000 3,906E-03 0,03652221 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 3,906E-03 0,03637435 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 1,000 3,906E-03 0,03622768 GO:0060415|muscle tissue morphogenesis, ! regulation of vasoconstriction GO:0019229 31 21 1,000 3,906E-03 0,03608219 ! platelet activation GO:0030168 28 21 1,000 3,906E-03 0,03593786 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 3,928E-03 0,03598921 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 4,285E-03 0,03910492 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 4,285E-03 0,03895036 ! vasculogenesis GO:0001570 33 22 1,000 4,285E-03 0,03879701 ! microtubule organizing center organization GO:0031023 28 22 1,000 4,285E-03 0,03864487 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 4,285E-03 0,03849391 ! blastocyst development GO:0001824 37 22 1,000 4,285E-03 0,03834413 ! protein tetramerization GO:0051262 39 22 1,000 4,285E-03 0,03819551 ! blood coagulation GO:0007596 116 75 2,000 4,581E-03 0,04068421 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 2,000 4,581E-03 0,04052773 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 4,679E-03 0,04123325 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 4,679E-03 0,04107587 ! myelination GO:0042552 35 23 1,000 4,679E-03 0,04091969 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 4,679E-03 0,04076469 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 4,679E-03 0,04061086 ! negative regulation of DNA replication GO:0008156 35 23 1,000 4,679E-03 0,04045819 ! interaction with host GO:0051701 37 23 1,000 4,679E-03 0,04030666 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 4,679E-03 0,04015626 ! negative regulation of catabolic process GO:0009895 34 23 1,000 4,679E-03 0,04000698 ! regulation of DNA binding GO:0051101 119 77 2,000 4,932E-03 0,04200952 ! gland development GO:0048732 148 77 2,000 4,932E-03 0,04185451 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 5,09E-03 0,04303835 ! receptor metabolic process GO:0043112 37 24 1,000 5,09E-03 0,0428807 ! positive regulation of protein modification process GO:0031401 107 78 2,000 5,113E-03 0,04291536 ! protein amino acid alkylation GO:0008213 39 25 1,000 5,516E-03 0,04613732 GO:0006479|protein amino acid methylation, ! positive regulation of nuclear division GO:0051785 39 25 1,000 5,516E-03 0,04597015 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 5,516E-03 0,0458042 ! hemostasis GO:0007599 125 81 2,000 5,679E-03 0,0469871 ! regulation of cell cycle process GO:0010564 122 81 2,000 5,679E-03 0,04681869 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 5,959E-03 0,04894833 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 5,959E-03 0,04877413 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 6,282E-03 0,05123925 ! response to ionizing radiation GO:0010212 47 27 1,000 6,417E-03 0,05215337 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 6,417E-03 0,05196973 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 6,417E-03 0,05178738 GO:0043433|negative regulation of transcription factor activity, ! gene silencing GO:0016458 41 27 1,000 6,417E-03 0,0516063 ! cell cycle arrest GO:0007050 150 86 2,000 6,705E-03 0,05373241 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 6,891E-03 0,0550314 ! response to organic cyclic substance GO:0014070 47 28 1,000 6,891E-03 0,05484098 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 6,891E-03 0,05465187 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 6,891E-03 0,05446407 ! ensheathment of neurons GO:0007272 43 28 1,000 6,891E-03 0,05427754 GO:0008366|axon ensheathment, ! reproductive developmental process GO:0003006 127 89 2,000 7,37E-03 0,05785076 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 7,38E-03 0,0577351 ! tissue homeostasis GO:0001894 42 29 1,000 7,38E-03 0,05753939 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 7,884E-03 0,06126454 ! regulation of microtubule-based process GO:0032886 58 30 1,000 7,884E-03 0,06105826 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 2,000 8,072E-03 0,06230254 ! DNA recombination GO:0006310 146 92 2,000 8,072E-03 0,06209417 ! negative regulation of secretion GO:0051048 49 31 1,000 8,404E-03 0,06443089 ! maintenance of protein location in cell GO:0032507 60 31 1,000 8,404E-03 0,06421683 ! cell fate specification GO:0001708 37 31 1,000 8,404E-03 0,0640042 ! regulation of binding GO:0051098 151 95 2,000 8,813E-03 0,06689752 ! angiogenesis GO:0001525 149 95 2,000 8,813E-03 0,06667746 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 8,939E-03 0,06740553 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 8,939E-03 0,06718525 ! peripheral nervous system development GO:0007422 53 32 1,000 8,939E-03 0,0669664 ! regulation of protein stability GO:0031647 48 32 1,000 8,939E-03 0,06674898 ! calcium-mediated signaling GO:0019722 50 32 1,000 8,939E-03 0,06653296 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 8,939E-03 0,06631834 ! in utero embryonic development GO:0001701 147 96 2,000 9,069E-03 0,0670662 ! response to light stimulus GO:0009416 153 96 2,000 9,069E-03 0,06685124 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 9,488E-03 0,0697196 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! carbohydrate homeostasis GO:0033500 39 33 1,000 9,488E-03 0,06949756 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 9,488E-03 0,06927694 ! negative regulation of DNA binding GO:0043392 54 33 1,000 9,488E-03 0,06905771 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 9,488E-03 0,06883986 ! cytokinesis GO:0000910 52 33 1,000 9,488E-03 0,06862338 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,010052 0,07247522 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,010052 0,07224873 ! female gamete generation GO:0007292 43 34 1,000 0,010052 0,07202366 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 2,000 0,01013375 0,07238392 ! regulation of body fluid levels GO:0050878 154 100 2,000 0,01013375 0,07215982 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,01063063 0,07546434 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,01063063 0,07523214 ! maintenance of protein location GO:0045185 65 35 1,000 0,01063063 0,07500137 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01063063 0,07477201 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01122368 0,07870266 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,01122368 0,07846344 ! negative regulation of binding GO:0051100 58 36 1,000 0,01122368 0,07822568 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01122368 0,07798935 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,01122368 0,07775444 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,01183103 0,0817158 ! regulation of protein secretion GO:0050708 51 37 1,000 0,01183103 0,08147114 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,01245252 0,08549491 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,01245252 0,08524046 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,01245252 0,08498752 ! maintenance of location in cell GO:0051651 69 38 1,000 0,01245252 0,08473608 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,01308803 0,08879784 ! developmental growth GO:0048589 62 39 1,000 0,01308803 0,08853667 ! synapse organization GO:0050808 55 39 1,000 0,01308803 0,08827703 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,01308803 0,08801891 ! regulation of tube size GO:0035150 60 40 1,000 0,01373742 0,09211682 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,01373742 0,09184903 ! double-strand break repair GO:0006302 67 40 1,000 0,01373742 0,09158281 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,01373742 0,09131811 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,01373742 0,09105495 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,01440056 0,09517612 ! endosome transport GO:0016197 71 41 1,000 0,01440056 0,09490341 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01440056 0,09463226 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01440056 0,09436265 ! biopolymer methylation GO:0043414 62 41 1,000 0,01440056 0,09409458 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,01507732 0,09823749 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,01507732 0,09795998 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,01507732 0,09768404 ! regulation of cell shape GO:0008360 78 42 1,000 0,01507732 0,09740964 ! positive regulation of binding GO:0051099 59 43 1,000 0,01576756 0,10158373 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,01576756 0,10129997 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,01576756 0,1010178 ! methylation GO:0032259 64 43 1,000 0,01576756 0,1007372 ! regulation of action potential GO:0001508 71 44 1,000 0,01647116 0,1049409 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,01647116 0,104651 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,01647116 0,10436271 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01647116 0,104076 ! positive regulation of defense response GO:0031349 59 45 1,000 0,01718798 0,10830782 ! cell maturation GO:0048469 60 45 1,000 0,01718798 0,1080119 ! cell redox homeostasis GO:0045454 63 46 1,000 0,0179179 0,112292 ! histone modification GO:0016570 68 46 1,000 0,0179179 0,11198686 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01866078 0,11631383 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01866078 0,11599947 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,01866078 0,1156868 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01866078 0,11537582 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,01941651 0,11972648 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,01941651 0,11940635 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,01941651 0,11908794 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,02018495 0,12347179 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,02018495 0,12314428 ! germ cell development GO:0007281 68 49 1,000 0,02018495 0,1228185 ! maintenance of location GO:0051235 84 49 1,000 0,02018495 0,12249444 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,02096598 0,12689938 ! lipid modification GO:0030258 73 50 1,000 0,02096598 0,12656631 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,02096598 0,12623499 ! muscle fiber development GO:0048747 74 51 1,000 0,02175948 0,13067051 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,02175948 0,13033022 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,02175948 0,1299917 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02211298 0,1317613 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02211298 0,13142083 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02211298 0,13108212 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02211298 0,13074515 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02211298 0,1304099 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02211298 0,13007637 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02211298 0,12974455 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02211298 0,12941441 ! sleep GO:0030431 11 5 0,000 0,02211298 0,12908594 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02211298 0,12875914 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02211298 0,12843399 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02211298 0,12811048 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02211298 0,1277886 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02211298 0,12746833 ! tongue development GO:0043586 6 5 0,000 0,02211298 0,12714965 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02211298 0,12683257 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02211298 0,12651707 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02211298 0,12620313 ! cobalt ion transport GO:0006824 9 5 0,000 0,02211298 0,12589075 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02211298 0,12557991 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02211298 0,1252706 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02211298 0,12496281 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02211298 0,12465652 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02211298 0,12435174 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02211298 0,12404844 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02211298 0,12374662 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02211298 0,12344627 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02211298 0,12314737 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02211298 0,12284991 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02211298 0,12255388 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02211298 0,12225928 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02211298 0,1219661 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02211298 0,12167431 ! malate metabolic process GO:0006108 7 5 0,000 0,02211298 0,12138392 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02211298 0,12109491 ! behavioral response to pain GO:0048266 7 5 0,000 0,02211298 0,12080727 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02211298 0,120521 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02211298 0,12023608 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02211298 0,1199525 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02211298 0,11967026 ! mating behavior GO:0007617 6 5 0,000 0,02211298 0,11938935 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02211298 0,11910975 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02211298 0,11883145 ! rhythmic behavior GO:0007622 12 5 0,000 0,02211298 0,11855446 ! copulation GO:0007620 7 5 0,000 0,02211298 0,11827875 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02211298 0,11800432 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02211298 0,11773116 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02211298 0,11745927 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02211298 0,11718862 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02211298 0,11691922 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02211298 0,11665106 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02211298 0,11638412 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02211298 0,11611841 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02211298 0,1158539 ! response to protozoan GO:0001562 9 5 0,000 0,02211298 0,1155906 ! lymph vessel development GO:0001945 7 5 0,000 0,02211298 0,11532848 ! endochondral ossification GO:0001958 12 5 0,000 0,02211298 0,11506756 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02211298 0,11480781 ! parathyroid gland development GO:0060017 8 5 0,000 0,02211298 0,11454924 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02211298 0,11429182 ! anagen GO:0042640 6 5 0,000 0,02211298 0,11403556 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02211298 0,11378045 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02211298 0,11352648 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02211298 0,11327363 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02211298 0,11302192 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02211298 0,11277131 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02211298 0,11252182 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02211298 0,11227343 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02211298 0,11202613 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02211298 0,11177992 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02211298 0,11153478 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02211298 0,11129073 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02211298 0,11104773 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02211298 0,1108058 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02211298 0,11056492 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02211298 0,11032508 ! ovulation GO:0030728 6 5 0,000 0,02211298 0,11008628 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02211298 0,10984851 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02211298 0,10961177 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,02211298 0,10937605 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02211298 0,10914133 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02211298 0,10890763 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02211298 0,10867492 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02211298 0,1084432 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02211298 0,10821247 ! polyol catabolic process GO:0046174 7 5 0,000 0,02211298 0,10798272 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02211298 0,10775394 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02211298 0,10752613 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02211298 0,10729929 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02211298 0,10707339 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02211298 0,10684845 ! urea metabolic process GO:0019627 6 5 0,000 0,02211298 0,10662445 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02211298 0,10640138 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02211298 0,10617925 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02211298 0,10595805 ! neutrophil activation GO:0042119 5 5 0,000 0,02211298 0,10573776 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02211298 0,10551839 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02211298 0,10529992 ! response to food GO:0032094 5 5 0,000 0,02211298 0,10508236 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02211298 0,10486569 GO:0043088|regulation of Cdc42 GTPase activity, ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02211298 0,10464992 ! forebrain neuron development GO:0021884 7 5 0,000 0,02211298 0,10443503 ! melanosome organization GO:0032438 7 5 0,000 0,02211298 0,10422103 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02211298 0,1040079 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02211298 0,10379564 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02211298 0,10358424 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02211298 0,1033737 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02211298 0,10316402 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02211298 0,10295519 ! nucleoside transport GO:0015858 6 5 0,000 0,02211298 0,1027472 ! nucleoside salvage GO:0043174 7 5 0,000 0,02211298 0,10254004 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02211298 0,10233373 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02211298 0,10212824 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02211298 0,10192357 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02211298 0,10171972 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02211298 0,10151669 ! depyrimidination GO:0045008 8 5 0,000 0,02211298 0,10131447 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02211298 0,10111305 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02211298 0,10091242 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02211298 0,1007126 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02211298 0,10051356 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02211298 0,10031531 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02211298 0,10011784 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02211298 0,09992114 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02211298 0,09972522 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02211298 0,09953006 ! monocyte differentiation GO:0030224 8 5 0,000 0,02211298 0,09933567 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02211298 0,09914203 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02211298 0,09894915 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02211298 0,09875701 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02211298 0,09856562 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02211298 0,09837497 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02211298 0,09818506 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02211298 0,09799588 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02211298 0,09780743 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02211298 0,0976197 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02211298 0,09743269 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02211298 0,09724639 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02211298 0,0970608 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02211298 0,09687593 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02211298 0,09669175 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02211298 0,09650828 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02211298 0,0963255 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02211298 0,09614341 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02211298 0,095962 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02211298 0,09578128 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02211298 0,09560124 ! neural tube patterning GO:0021532 6 5 0,000 0,02211298 0,09542188 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02211298 0,09524319 ! histone demethylation GO:0016577 9 5 0,000 0,02211298 0,09506516 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02211298 0,0948878 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02211298 0,0947111 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02211298 0,09453506 ! enteric nervous system development GO:0048484 8 5 0,000 0,02211298 0,09435967 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02211298 0,09418493 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02211298 0,09401084 ! transcription termination GO:0006353 8 5 0,000 0,02211298 0,09383738 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02211298 0,09366457 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02211298 0,09349239 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02211298 0,09332085 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02211298 0,09314993 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02211298 0,09297964 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02211298 0,09280997 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02211298 0,09264091 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02211298 0,09247248 ! apical protein localization GO:0045176 6 5 0,000 0,02211298 0,09230465 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02211298 0,09213743 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02211298 0,09197082 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02211298 0,0918048 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02211298 0,09163939 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02211298 0,09147457 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02211298 0,09131034 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02211298 0,09114671 ! glial cell migration GO:0008347 10 5 0,000 0,02211298 0,09098365 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02211298 0,09082118 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02211298 0,09065929 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02211298 0,09049797 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02211298 0,09033723 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02211298 0,09017706 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02211298 0,09001745 ! neural plate development GO:0001840 6 5 0,000 0,02211298 0,08985841 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02211298 0,08969993 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02211298 0,08954201 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02211298 0,08938464 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02211298 0,08922783 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02211298 0,08907156 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02211298 0,08891584 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02211298 0,08876067 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02211298 0,08860603 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02211298 0,08845193 ! spindle assembly GO:0051225 5 5 0,000 0,02211298 0,08829837 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02211298 0,08814534 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02211298 0,08799284 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02211298 0,08784087 ! organ regeneration GO:0031100 7 5 0,000 0,02211298 0,08768942 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02211298 0,08753849 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02211298 0,08738808 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02211298 0,08723818 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02211298 0,0870888 GO:0055081|anion homeostasis, ! aging GO:0007568 79 52 1,000 0,02256532 0,08871834 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,02256532 0,08856695 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,02338337 0,09162139 ! kidney development GO:0001822 90 53 1,000 0,02338337 0,09146557 ! cell projection assembly GO:0030031 76 53 1,000 0,02338337 0,09131028 ! regulation of mitosis GO:0007088 84 54 1,000 0,02421352 0,0943917 GO:0051783|regulation of nuclear division, ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,02421352 0,09423199 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,02590963 0,10066242 ! tRNA transcription GO:0009304 11 6 0,000 0,0264773 0,10269442 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,0264773 0,10252154 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,0264773 0,10234923 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,0264773 0,10217751 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0264773 0,10200635 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,0264773 0,10183577 ! regulation of helicase activity GO:0051095 11 6 0,000 0,0264773 0,10166577 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,0264773 0,10149632 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,0264773 0,10132744 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,0264773 0,10115913 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,0264773 0,10099137 ! prostate gland development GO:0030850 9 6 0,000 0,0264773 0,10082416 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,0264773 0,10065751 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,0264773 0,10049141 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,0264773 0,10032585 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,0264773 0,10016084 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,0264773 0,09999638 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,0264773 0,09983245 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,0264773 0,09966906 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,0264773 0,0995062 ! neuron adhesion GO:0007158 9 6 0,000 0,0264773 0,09934387 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,0264773 0,09918207 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,0264773 0,0990208 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,0264773 0,09886005 ! signal peptide processing GO:0006465 8 6 0,000 0,0264773 0,09869983 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,0264773 0,09854012 ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,0264773 0,09838093 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,0264773 0,09822225 ! opsonization GO:0008228 8 6 0,000 0,0264773 0,09806408 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,0264773 0,09790642 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,0264773 0,09774927 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,0264773 0,09759262 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,0264773 0,09743647 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,0264773 0,09728082 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0264773 0,09712567 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,0264773 0,09697101 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,0264773 0,09681684 ! mechanosensory behavior GO:0007638 8 6 0,000 0,0264773 0,09666316 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,0264773 0,09650997 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,0264773 0,09635727 ! response to interferon-gamma GO:0034341 12 6 0,000 0,0264773 0,09620504 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,0264773 0,0960533 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,0264773 0,09590204 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0264773 0,09575125 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,0264773 0,09560093 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,0264773 0,09545109 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,0264773 0,09530171 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,0264773 0,0951528 ! thymic T cell selection GO:0045061 12 6 0,000 0,0264773 0,09500436 ! protein lipoylation GO:0009249 10 6 0,000 0,0264773 0,09485638 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,0264773 0,09470885 ! pigment granule organization GO:0048753 11 6 0,000 0,0264773 0,09456179 ! drug transport GO:0015893 6 6 0,000 0,0264773 0,09441518 ! cysteine metabolic process GO:0006534 7 6 0,000 0,0264773 0,09426903 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,0264773 0,09412333 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,0264773 0,09397808 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,0264773 0,09383327 ! histidine metabolic process GO:0006547 6 6 0,000 0,0264773 0,09368891 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,0264773 0,093545 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,0264773 0,09340152 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,0264773 0,09325849 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,0264773 0,09311589 ! adenohypophysis development GO:0021984 10 6 0,000 0,0264773 0,09297373 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,0264773 0,092832 ! hyperosmotic response GO:0006972 8 6 0,000 0,0264773 0,09269071 ! microtubule nucleation GO:0007020 10 6 0,000 0,0264773 0,09254984 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,0264773 0,0924094 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,0264773 0,09226938 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,0264773 0,09212979 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,0264773 0,09199062 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,0264773 0,09185188 ! response to dietary excess GO:0002021 7 6 0,000 0,0264773 0,09171354 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,0264773 0,09157563 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,0264773 0,09143813 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,0264773 0,09130104 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,0264773 0,09116436 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,0264773 0,09102809 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,0264773 0,09089223 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0264773 0,09075677 ! neuron apoptosis GO:0051402 8 6 0,000 0,0264773 0,09062172 ! organic alcohol transport GO:0015850 9 6 0,000 0,0264773 0,09048706 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,0264773 0,09035281 ! T cell mediated immunity GO:0002456 12 6 0,000 0,0264773 0,09021895 ! carnitine transport GO:0015879 8 6 0,000 0,0264773 0,09008549 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,0264773 0,08995243 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,0264773 0,08981975 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0264773 0,08968747 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,0264773 0,08955558 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,0264773 0,08942407 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,0264773 0,08929295 ! parturition GO:0007567 12 6 0,000 0,0264773 0,08916222 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,0264773 0,08903186 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,0264773 0,08890189 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,0264773 0,08877229 ! spindle checkpoint GO:0031577 14 6 0,000 0,0264773 0,08864308 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,0264773 0,08851423 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,0264773 0,08838577 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,0264773 0,08825767 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,0264773 0,08812995 ! macrophage differentiation GO:0030225 10 6 0,000 0,0264773 0,08800259 ! astrocyte development GO:0014002 14 6 0,000 0,0264773 0,0878756 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,0264773 0,08774898 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,0264773 0,08762272 ! interaction with symbiont GO:0051702 8 6 0,000 0,0264773 0,08749683 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,0264773 0,0873713 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0264773 0,08724612 ! eating behavior GO:0042755 6 6 0,000 0,0264773 0,08712131 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,0264773 0,08699685 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,0264773 0,08687274 ! response to copper ion GO:0046688 9 6 0,000 0,0264773 0,08674899 ! DNA topological change GO:0006265 8 6 0,000 0,0264773 0,0866256 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,0264773 0,08650255 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,0264773 0,08637985 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,0264773 0,0862575 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0264773 0,08613549 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,0264773 0,08601383 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,0264773 0,08589252 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,0264773 0,08577154 ! gas homeostasis GO:0033483 11 6 0,000 0,0264773 0,0856509 ! hair follicle maturation GO:0048820 7 6 0,000 0,0264773 0,08553061 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,0264773 0,08541065 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,0264773 0,08529103 ! Schwann cell development GO:0014044 14 6 0,000 0,0264773 0,08517174 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,0264773 0,08505278 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,0264773 0,08493416 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0264773 0,08481587 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,0264773 0,0846979 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,0264773 0,08458027 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,0264773 0,08446296 ! histone ubiquitination GO:0016574 7 6 0,000 0,0264773 0,08434597 ! regulation of meiosis GO:0040020 10 6 0,000 0,0264773 0,08422931 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,0264773 0,08411297 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,0264773 0,08399696 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,0264773 0,08388126 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,0264773 0,08376588 ! membrane to membrane docking GO:0022614 12 6 0,000 0,0264773 0,08365082 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,0264773 0,08353607 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,0264773 0,08342163 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,0264773 0,08330751 ! receptor internalization GO:0031623 9 6 0,000 0,0264773 0,08319371 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,0264773 0,08308021 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,0264773 0,08296702 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0264773 0,08285414 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,0264773 0,08274157 ! protein deubiquitination GO:0016579 8 6 0,000 0,0264773 0,0826293 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,0264773 0,08251734 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,0264773 0,08240567 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,0264773 0,08229432 ! axonal fasciculation GO:0007413 9 6 0,000 0,0264773 0,08218326 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,0264773 0,0820725 ! thiamin metabolic process GO:0006772 6 6 0,000 0,0264773 0,08196204 ! midbrain development GO:0030901 6 6 0,000 0,0264773 0,08185187 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,0264773 0,081742 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0264773 0,08163243 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,0264773 0,08152315 ! progesterone metabolic process GO:0042448 8 6 0,000 0,0264773 0,08141416 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,0264773 0,08130547 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,0264773 0,08119706 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,0264773 0,08108894 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,0264773 0,08098111 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,0264773 0,08087356 ! adult feeding behavior GO:0008343 6 6 0,000 0,0264773 0,0807663 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,0264773 0,08065933 ! pigment granule transport GO:0051904 12 6 0,000 0,0264773 0,08055264 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,0264773 0,08044623 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,0264773 0,0803401 ! catecholamine transport GO:0051937 7 6 0,000 0,0264773 0,08023425 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0264773 0,08012868 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,0264773 0,08002338 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,0264773 0,07991836 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,0264773 0,07981362 ! protein prenylation GO:0018342 10 6 0,000 0,0264773 0,07970915 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0264773 0,07960496 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,0264773 0,07950104 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,0264773 0,07939738 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,0264773 0,079294 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,02677535 0,08008231 ! developmental maturation GO:0021700 75 57 1,000 0,02677535 0,07997831 ! gonad development GO:0008406 79 57 1,000 0,02677535 0,07987457 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,02765268 0,08238492 ! viral reproductive process GO:0022415 87 58 1,000 0,02765268 0,08227834 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,02765268 0,08217204 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,02854151 0,08470383 ! actin filament organization GO:0007015 95 59 1,000 0,02854151 0,08459467 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,02854151 0,0844858 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,02944172 0,08703849 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,02944172 0,08692676 ! meiosis GO:0007126 96 61 1,000 0,03035319 0,089503 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,03035319 0,0893884 ! urogenital system development GO:0001655 101 61 1,000 0,03035319 0,08927409 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,03035319 0,08916007 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03082239 0,09042283 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03082239 0,09030764 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03082239 0,09019274 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03082239 0,09007814 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03082239 0,08996383 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03082239 0,08984981 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03082239 0,08973607 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03082239 0,08962263 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03082239 0,08950947 ! reproductive behavior GO:0019098 12 7 0,000 0,03082239 0,08939659 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03082239 0,089284 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,03082239 0,08917169 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03082239 0,08905967 ! oligopeptide transport GO:0006857 11 7 0,000 0,03082239 0,08894793 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03082239 0,08883646 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03082239 0,08872528 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03082239 0,08861437 ! RNA methylation GO:0001510 11 7 0,000 0,03082239 0,08850374 ! pericardium development GO:0060039 8 7 0,000 0,03082239 0,08839339 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03082239 0,08828331 ! fibril organization GO:0043206 13 7 0,000 0,03082239 0,0881735 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03082239 0,08806397 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,03082239 0,08795471 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03082239 0,08784572 ! lipoprotein transport GO:0042953 9 7 0,000 0,03082239 0,087737 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03082239 0,08762855 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03082239 0,08752037 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03082239 0,08741245 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03082239 0,0873048 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03082239 0,08719741 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03082239 0,08709029 ! chemosensory behavior GO:0007635 9 7 0,000 0,03082239 0,08698343 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03082239 0,08687684 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03082239 0,0867705 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03082239 0,08666442 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03082239 0,0865586 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03082239 0,08645305 ! reflex GO:0060004 12 7 0,000 0,03082239 0,08634774 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03082239 0,0862427 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03082239 0,08613791 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03082239 0,08603337 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03082239 0,08592909 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03082239 0,08582506 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03082239 0,08572128 ! spinal cord patterning GO:0021511 7 7 0,000 0,03082239 0,08561775 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03082239 0,08551447 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03082239 0,08541144 ! adrenal gland development GO:0030325 17 7 0,000 0,03082239 0,08530866 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03082239 0,08520613 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03082239 0,08510384 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03082239 0,0850018 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03082239 0,0849 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03082239 0,08479844 ! endosome organization GO:0007032 10 7 0,000 0,03082239 0,08469713 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03082239 0,08459606 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03082239 0,08449523 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03082239 0,08439464 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03082239 0,08429429 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03082239 0,08419418 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03082239 0,0840943 ! galactose metabolic process GO:0006012 10 7 0,000 0,03082239 0,08399467 ! vesicle fusion GO:0006906 15 7 0,000 0,03082239 0,08389526 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03082239 0,0837961 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03082239 0,08369716 ! organ growth GO:0035265 11 7 0,000 0,03082239 0,08359846 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03082239 0,0835 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,03082239 0,08340176 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03082239 0,08330376 ! retinol metabolic process GO:0042572 9 7 0,000 0,03082239 0,08320598 ! behavioral fear response GO:0001662 13 7 0,000 0,03082239 0,08310844 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03082239 0,08301112 ! rRNA modification GO:0000154 12 7 0,000 0,03082239 0,08291403 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03082239 0,08281717 ! response to UV-B GO:0010224 11 7 0,000 0,03082239 0,08272053 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03082239 0,08262412 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03082239 0,08252794 ! intermediate filament organization GO:0045109 11 7 0,000 0,03082239 0,08243197 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03082239 0,08233623 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03082239 0,08224072 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03082239 0,08214542 ! B cell lineage commitment GO:0002326 17 7 0,000 0,03082239 0,08205034 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03082239 0,08195549 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03082239 0,08186085 ! response to tropane GO:0014073 13 7 0,000 0,03082239 0,08176643 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03082239 0,08167223 ! melanosome localization GO:0032400 10 7 0,000 0,03082239 0,08157825 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03082239 0,08148448 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03082239 0,08139093 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03082239 0,08129759 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03082239 0,08120446 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03082239 0,08111155 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03082239 0,08101885 ! mast cell activation GO:0045576 9 7 0,000 0,03082239 0,08092637 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03082239 0,08083409 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03082239 0,08074202 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03082239 0,08065017 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03082239 0,08055852 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,03082239 0,08046708 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03082239 0,08037585 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03082239 0,08028482 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03082239 0,080194 ! T cell lineage commitment GO:0002360 12 7 0,000 0,03082239 0,08010339 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03082239 0,08001298 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03082239 0,07992277 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03082239 0,07983277 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03082239 0,07974297 ! response to tumor cell GO:0002347 12 7 0,000 0,03082239 0,07965337 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03082239 0,07956397 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03082239 0,07947477 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03082239 0,07938578 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03082239 0,07929698 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03082239 0,07920838 ! diuresis GO:0030146 12 7 0,000 0,03082239 0,07911997 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03082239 0,07903177 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03082239 0,07894376 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03082239 0,07885595 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03082239 0,07876833 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03082239 0,07868091 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03082239 0,07859368 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03082239 0,07850664 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03082239 0,0784198 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03082239 0,07833315 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03082239 0,07824669 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03082239 0,07816042 ! lymph node development GO:0048535 9 7 0,000 0,03082239 0,07807434 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03082239 0,07798845 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03082239 0,07790274 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03082239 0,07781723 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03082239 0,07773191 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03082239 0,07764677 ! ATP catabolic process GO:0006200 10 7 0,000 0,03082239 0,07756181 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03082239 0,07747705 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03082239 0,07739246 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03082239 0,07730807 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03082239 0,07722385 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03082239 0,07713982 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03082239 0,07705598 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03082239 0,07697231 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03082239 0,07688883 ! retina homeostasis GO:0001895 9 7 0,000 0,03082239 0,07680552 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03082239 0,0767224 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03082239 0,07663946 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03082239 0,07655669 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03082239 0,07647411 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03082239 0,0763917 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03082239 0,07630947 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03082239 0,07622742 ! meiotic cell cycle GO:0051321 97 62 1,000 0,03127581 0,0772657 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,03220947 0,07948689 ! viral reproduction GO:0016032 92 63 1,000 0,03220947 0,07940169 ! adaptive immune response GO:0002250 94 64 1,000 0,03315405 0,08164272 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,03410943 0,08390554 ! regulation of caspase activity GO:0043281 97 65 1,000 0,03410943 0,0838159 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,0350755 0,08609782 ! axon guidance GO:0007411 99 66 1,000 0,0350755 0,08600603 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03514833 0,08609283 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03514833 0,08600124 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,03514833 0,08590985 ! axon extension GO:0048675 11 8 0,000 0,03514833 0,08581865 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03514833 0,08572764 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03514833 0,08563683 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03514833 0,08554621 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03514833 0,08545578 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03514833 0,08536554 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03514833 0,08527549 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,03514833 0,08518563 ! phosphate transport GO:0006817 10 8 0,000 0,03514833 0,08509596 ! N-glycan processing GO:0006491 12 8 0,000 0,03514833 0,08500648 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03514833 0,08491719 ! UTP metabolic process GO:0046051 8 8 0,000 0,03514833 0,08482809 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03514833 0,08473917 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03514833 0,08465044 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03514833 0,08456189 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03514833 0,08447353 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03514833 0,08438535 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03514833 0,08429736 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03514833 0,08420955 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03514833 0,08412192 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03514833 0,08403448 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03514833 0,08394721 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03514833 0,08386013 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03514833 0,08377323 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03514833 0,08368651 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03514833 0,08359997 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03514833 0,0835136 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03514833 0,08342742 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03514833 0,08334141 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03514833 0,08325558 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03514833 0,08316992 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03514833 0,08308445 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03514833 0,08299914 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03514833 0,08291402 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03514833 0,08282906 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03514833 0,08274428 ! melanin metabolic process GO:0006582 12 8 0,000 0,03514833 0,08265968 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03514833 0,08257525 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03514833 0,08249099 ! macrophage activation GO:0042116 12 8 0,000 0,03514833 0,0824069 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03514833 0,08232298 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03514833 0,08223923 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03514833 0,08215566 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03514833 0,08207225 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03514833 0,08198901 ! ruffle organization GO:0031529 11 8 0,000 0,03514833 0,08190594 ! osteoblast development GO:0002076 13 8 0,000 0,03514833 0,08182304 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03514833 0,08174031 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03514833 0,08165774 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03514833 0,08157534 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03514833 0,08149311 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03514833 0,08141104 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03514833 0,08132914 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03514833 0,0812474 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03514833 0,08116583 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03514833 0,08108442 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03514833 0,08100317 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03514833 0,08092209 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03514833 0,08084117 ! segment specification GO:0007379 10 8 0,000 0,03514833 0,08076041 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03514833 0,08067981 ! cellular extravasation GO:0045123 11 8 0,000 0,03514833 0,08059937 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03514833 0,08051909 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03514833 0,08043897 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03514833 0,08035901 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03514833 0,08027921 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03514833 0,08019957 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03514833 0,08012009 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03514833 0,08004076 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03514833 0,07996159 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03514833 0,07988258 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03514833 0,07980372 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03514833 0,07972502 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03514833 0,07964647 ! icosanoid secretion GO:0032309 12 8 0,000 0,03514833 0,07956808 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03514833 0,07948984 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03514833 0,07941175 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03514833 0,07933382 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03514833 0,07925605 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03514833 0,07917842 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03514833 0,07910095 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03514833 0,07902362 ! sterol catabolic process GO:0016127 9 8 0,000 0,03514833 0,07894645 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03514833 0,07886943 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03514833 0,07879256 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03514833 0,07871584 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03514833 0,07863927 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03514833 0,07856284 ! prophase GO:0051324 11 8 0,000 0,03514833 0,07848657 ! S phase GO:0051320 8 8 0,000 0,03514833 0,07841044 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03514833 0,07833446 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03514833 0,07825863 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03514833 0,07818295 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03514833 0,07810741 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03514833 0,07803201 ! hormone catabolic process GO:0042447 13 8 0,000 0,03514833 0,07795677 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03514833 0,07788166 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03514833 0,0778067 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03514833 0,07773189 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03514833 0,07765722 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03514833 0,07758269 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03514833 0,07750831 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03514833 0,07743407 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03514833 0,07735997 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03514833 0,07728601 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03514833 0,07721219 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03514833 0,07713852 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03514833 0,07706498 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03514833 0,07699159 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03514833 0,07691833 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,03605216 0,07882127 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,03703929 0,08090254 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,03904452 0,08520152 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,03904452 0,08512076 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03945521 0,08593465 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03945521 0,08585335 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03945521 0,0857722 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03945521 0,08569121 ! CTP metabolic process GO:0046036 9 9 0,000 0,03945521 0,08561037 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03945521 0,08552968 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03945521 0,08544914 ! GTP metabolic process GO:0046039 9 9 0,000 0,03945521 0,08536876 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03945521 0,08528853 ! social behavior GO:0035176 14 9 0,000 0,03945521 0,08520844 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03945521 0,08512851 ! artery development GO:0060840 19 9 0,000 0,03945521 0,08504873 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03945521 0,08496909 ! response to pain GO:0048265 16 9 0,000 0,03945521 0,08488961 ! protein complex disassembly GO:0043241 17 9 0,000 0,03945521 0,08481027 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03945521 0,08473108 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03945521 0,08465204 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03945521 0,08457315 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03945521 0,08449441 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03945521 0,08441581 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03945521 0,08433735 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03945521 0,08425905 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03945521 0,08418088 ! protein targeting to ER GO:0045047 19 9 0,000 0,03945521 0,08410287 ! T cell selection GO:0045058 18 9 0,000 0,03945521 0,08402499 ! endoderm development GO:0007492 12 9 0,000 0,03945521 0,08394726 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03945521 0,08386968 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03945521 0,08379224 ! arginine catabolic process GO:0006527 10 9 0,000 0,03945521 0,08371494 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03945521 0,08363778 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03945521 0,08356077 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03945521 0,08348389 ! V(D)J recombination GO:0033151 12 9 0,000 0,03945521 0,08340716 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03945521 0,08333057 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03945521 0,08325412 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03945521 0,08317781 ! mannose metabolic process GO:0006013 9 9 0,000 0,03945521 0,08310164 ! epithelial cell development GO:0002064 10 9 0,000 0,03945521 0,08302561 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03945521 0,08294972 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03945521 0,08287396 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03945521 0,08279835 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03945521 0,08272287 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03945521 0,08264753 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03945521 0,08257233 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03945521 0,08249727 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03945521 0,08242234 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03945521 0,08234754 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03945521 0,08227288 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03945521 0,08219836 ! DNA ligation GO:0006266 14 9 0,000 0,03945521 0,08212397 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03945521 0,08204972 ! response to amine stimulus GO:0014075 13 9 0,000 0,03945521 0,0819756 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03945521 0,08190162 ! erythrocyte development GO:0048821 11 9 0,000 0,03945521 0,08182777 ! renal water homeostasis GO:0003091 14 9 0,000 0,03945521 0,08175405 ! postreplication repair GO:0006301 11 9 0,000 0,03945521 0,08168046 ! mRNA cleavage GO:0006379 13 9 0,000 0,03945521 0,08160701 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03945521 0,08153369 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03945521 0,0814605 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03945521 0,08138744 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03945521 0,08131451 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03945521 0,08124171 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03945521 0,08116904 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03945521 0,08109651 ! acid secretion GO:0046717 14 9 0,000 0,03945521 0,0810241 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03945521 0,08095182 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03945521 0,08087967 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03945521 0,08080765 ! purine base metabolic process GO:0006144 18 9 0,000 0,03945521 0,08073576 ! thymus development GO:0048538 15 9 0,000 0,03945521 0,08066399 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03945521 0,08059235 ! spleen development GO:0048536 15 9 0,000 0,03945521 0,08052084 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03945521 0,08044946 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03945521 0,0803782 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03945521 0,08030707 ! detection of calcium ion GO:0005513 13 9 0,000 0,03945521 0,08023607 ! blastocyst formation GO:0001825 12 9 0,000 0,03945521 0,08016519 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03945521 0,08009443 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03945521 0,0800238 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03945521 0,0799533 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03945521 0,07988292 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03945521 0,07981266 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03945521 0,07974252 ! prepulse inhibition GO:0060134 14 9 0,000 0,03945521 0,07967251 ! embryonic placenta development GO:0001892 12 9 0,000 0,03945521 0,07960262 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03945521 0,07953286 ! insulin secretion GO:0030073 17 9 0,000 0,03945521 0,07946321 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03945521 0,07939369 ! response to nicotine GO:0035094 16 9 0,000 0,03945521 0,07932429 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03945521 0,07925501 ! nucleus localization GO:0051647 15 9 0,000 0,03945521 0,07918586 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03945521 0,07911682 ! muscle cell differentiation GO:0042692 104 71 1,000 0,04006241 0,08026441 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,04109033 0,08225218 ! regulation of blood pressure GO:0008217 107 73 1,000 0,04212817 0,08425634 ! tube morphogenesis GO:0035239 118 73 1,000 0,04212817 0,08418314 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,04212817 0,08411007 ! mitochondrion organization GO:0007005 104 73 1,000 0,04212817 0,08403712 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04374311 0,08718298 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04374311 0,0871075 ! neuron fate specification GO:0048665 11 10 0,000 0,04374311 0,08703215 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04374311 0,08695693 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04374311 0,08688183 ! thyroid gland development GO:0030878 19 10 0,000 0,04374311 0,08680687 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,04374311 0,08673204 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04374311 0,08665733 ! synapsis GO:0007129 13 10 0,000 0,04374311 0,08658276 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04374311 0,08650831 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04374311 0,08643399 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04374311 0,0863598 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04374311 0,08628573 ! sulfate transport GO:0008272 12 10 0,000 0,04374311 0,08621179 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04374311 0,08613798 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,04374311 0,0860643 ! androgen metabolic process GO:0008209 13 10 0,000 0,04374311 0,08599074 ! phospholipid efflux GO:0033700 16 10 0,000 0,04374311 0,0859173 ! hippocampus development GO:0021766 19 10 0,000 0,04374311 0,085844 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04374311 0,08577081 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04374311 0,08569775 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04374311 0,08562482 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 0,000 0,04374311 0,08555201 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04374311 0,08547932 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04374311 0,08540676 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04374311 0,08533432 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,04374311 0,085262 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04374311 0,08518981 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04374311 0,08511774 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04374311 0,08504579 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04374311 0,08497396 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04374311 0,08490225 ! B cell proliferation GO:0042100 14 10 0,000 0,04374311 0,08483066 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04374311 0,08475919 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04374311 0,08468785 ! forebrain cell migration GO:0021885 17 10 0,000 0,04374311 0,08461662 ! lipid digestion GO:0044241 15 10 0,000 0,04374311 0,08454552 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04374311 0,08447453 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04374311 0,08440366 ! UV protection GO:0009650 14 10 0,000 0,04374311 0,08433291 ! entry into host cell GO:0030260 20 10 0,000 0,04374311 0,08426228 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04374311 0,08419177 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04374311 0,08412137 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04374311 0,0840511 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04374311 0,08398094 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04374311 0,0839109 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04374311 0,08384097 ! regulation of organ growth GO:0046620 11 10 0,000 0,04374311 0,08377116 ! response to dsRNA GO:0043331 18 10 0,000 0,04374311 0,08370147 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04374311 0,08363189 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04374311 0,08356243 ! embryonic axis specification GO:0000578 12 10 0,000 0,04374311 0,08349308 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04374311 0,08342385 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04374311 0,08335473 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04374311 0,08328573 ! cranial nerve development GO:0021545 12 10 0,000 0,04374311 0,08321684 ! fucose catabolic process GO:0019317 16 10 0,000 0,04374311 0,08314807 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,04374311 0,08307941 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04374311 0,08301086 ! protein sumoylation GO:0016925 12 10 0,000 0,04374311 0,08294243 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04374311 0,08287411 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04374311 0,0828059 ! zymogen activation GO:0031638 14 10 0,000 0,04374311 0,0827378 ! salivary gland development GO:0007431 22 10 0,000 0,04374311 0,08266981 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04374311 0,08260194 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04374311 0,08253418 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04374311 0,08246653 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04374311 0,08239899 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04374311 0,08233156 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04374311 0,08226424 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04374311 0,08219703 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04374311 0,08212993 ! detection of bacterium GO:0016045 10 10 0,000 0,04374311 0,08206294 ! embryonic gut development GO:0048566 11 10 0,000 0,04374311 0,08199606 ! activation of innate immune response GO:0002218 10 10 0,000 0,04374311 0,08192929 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04374311 0,08186262 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04374311 0,08179607 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04374311 0,08172962 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04374311 0,08166328 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,04530021 0,08450161 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,04637671 0,08643958 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,04637671 0,08636958 ! sex differentiation GO:0007548 105 77 1,000 0,04637671 0,08629971 ! protein ubiquitination GO:0016567 125 77 1,000 0,04637671 0,08622994 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,04637671 0,08616029 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,04746261 0,08810654 ! rRNA transcription GO:0009303 17 11 0,000 0,04801212 0,08905474 ! respiratory burst GO:0045730 14 11 0,000 0,04801212 0,08898298 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04801212 0,08891133 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04801212 0,0888398 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04801212 0,08876839 ! filopodium assembly GO:0046847 19 11 0,000 0,04801212 0,08869709 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04801212 0,0886259 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04801212 0,08855483 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04801212 0,08848387 ! mating GO:0007618 14 11 0,000 0,04801212 0,08841303 ! T cell proliferation GO:0042098 20 11 0,000 0,04801212 0,0883423 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04801212 0,08827168 ! bone resorption GO:0045453 16 11 0,000 0,04801212 0,08820118 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04801212 0,08813078 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04801212 0,0880605 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04801212 0,08799034 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04801212 0,08792028 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04801212 0,08785034 ! syncytium formation GO:0006949 15 11 0,000 0,04801212 0,0877805 ! plasma membrane organization GO:0007009 18 11 0,000 0,04801212 0,08771078 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04801212 0,08764117 ! focal adhesion formation GO:0048041 24 11 0,000 0,04801212 0,08757167 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04801212 0,08750228 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04801212 0,087433 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,04801212 0,08736382 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04801212 0,08729476 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04801212 0,08722581 ! adult heart development GO:0007512 11 11 0,000 0,04801212 0,08715696 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04801212 0,08708823 ! temperature homeostasis GO:0001659 16 11 0,000 0,04801212 0,0870196 ! L-glutamate transport GO:0015813 16 11 0,000 0,04801212 0,08695108 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04801212 0,08688267 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04801212 0,08681437 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04801212 0,08674617 ! stem cell development GO:0048864 29 11 0,000 0,04801212 0,08667808 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04801212 0,0866101 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04801212 0,08654222 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04801212 0,08647445 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04801212 0,08640679 ! vasoconstriction GO:0042310 15 11 0,000 0,04801212 0,08633923 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04801212 0,08627178 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04801212 0,08620443 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04801212 0,08613719 ! ribosome assembly GO:0042255 13 11 0,000 0,04801212 0,08607005 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04801212 0,08600302 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04801212 0,08593609 ! nucleosome positioning GO:0016584 13 11 0,000 0,04801212 0,08586926 ! T cell homeostasis GO:0043029 20 11 0,000 0,04801212 0,08580254 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04801212 0,08573593 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04801212 0,08566941 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04801212 0,085603 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04801212 0,08553669 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04801212 0,08547049 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04801212 0,08540439 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04801212 0,08533839 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04801212 0,08527249 ! male genitalia development GO:0030539 13 11 0,000 0,04801212 0,08520669 ! cholesterol efflux GO:0033344 19 11 0,000 0,04801212 0,085141 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04801212 0,0850754 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04801212 0,08500991 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04801212 0,08494452 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04801212 0,08487923 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04801212 0,08481403 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04801212 0,08474894 ! defense response to fungus GO:0050832 12 11 0,000 0,04801212 0,08468395 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04801212 0,08461906 ! lysogeny GO:0030069 18 11 0,000 0,04801212 0,08455427 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04801212 0,08448957 ! acrosome reaction GO:0007340 13 11 0,000 0,04801212 0,08442498 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04801212 0,08436048 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,04855781 0,08525417 ! regulation of lyase activity GO:0051339 133 79 1,000 0,04855781 0,08518914 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,0507757 0,08901227 ! vitamin metabolic process GO:0006766 103 81 1,000 0,0507757 0,08894448 ! ossification GO:0001503 134 82 1,000 0,05189818 0,09084157 GO:0060348|bone development, ! lactation GO:0007595 20 12 0,000 0,05226231 0,09140936 ! reproductive cellular process GO:0048610 14 12 0,000 0,05226231 0,0913399 ! tRNA modification GO:0006400 14 12 0,000 0,05226231 0,09127055 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05226231 0,0912013 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05226231 0,09113215 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05226231 0,09106311 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05226231 0,09099418 ! non-recombinational repair GO:0000726 19 12 0,000 0,05226231 0,09092535 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05226231 0,09085662 ! peroxisomal transport GO:0043574 21 12 0,000 0,05226231 0,090788 ! cartilage condensation GO:0001502 18 12 0,000 0,05226231 0,09071948 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05226231 0,09065106 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05226231 0,09058275 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05226231 0,09051454 ! heart looping GO:0001947 15 12 0,000 0,05226231 0,09044643 ! palate development GO:0060021 15 12 0,000 0,05226231 0,09037843 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05226231 0,09031052 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05226231 0,09024272 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05226231 0,09017502 ! arginine metabolic process GO:0006525 13 12 0,000 0,05226231 0,09010743 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05226231 0,09003993 ! methionine metabolic process GO:0006555 13 12 0,000 0,05226231 0,08997254 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05226231 0,08990524 ! Golgi organization GO:0007030 18 12 0,000 0,05226231 0,08983805 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05226231 0,08977095 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05226231 0,08970396 ! monoamine transport GO:0015844 13 12 0,000 0,05226231 0,08963707 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05226231 0,08957027 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05226231 0,08950358 ! L-amino acid transport GO:0015807 20 12 0,000 0,05226231 0,08943699 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05226231 0,08937049 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05226231 0,08930409 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05226231 0,08923779 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05226231 0,08917159 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05226231 0,08910549 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05226231 0,08903949 ! cerebellum development GO:0021549 13 12 0,000 0,05226231 0,08897358 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05226231 0,08890777 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05226231 0,08884206 ! histone methylation GO:0016571 15 12 0,000 0,05226231 0,08877645 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05226231 0,08871093 ! gland morphogenesis GO:0022612 23 12 0,000 0,05226231 0,08864551 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05226231 0,08858018 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,05226231 0,08851495 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05226231 0,08844982 ! regulation of epidermis development GO:0045682 17 12 0,000 0,05226231 0,08838479 ! intestinal absorption GO:0050892 19 12 0,000 0,05226231 0,08831984 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05226231 0,088255 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05226231 0,08819025 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05226231 0,08812559 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05226231 0,08806103 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05226231 0,08799657 ! microspike assembly GO:0030035 23 12 0,000 0,05226231 0,08793219 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05226231 0,08786792 ! response to cold GO:0009409 14 12 0,000 0,05226231 0,08780373 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,05302956 0,08902773 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,05302956 0,0889628 ! regulation of defense response GO:0031347 117 84 1,000 0,05416974 0,09080933 ! sterol metabolic process GO:0016125 120 84 1,000 0,05416974 0,09074319 ! transcription initiation GO:0006352 118 85 1,000 0,05531861 0,09260029 ! regulation of membrane potential GO:0042391 128 85 1,000 0,05531861 0,09253295 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,05647608 0,09440042 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,05647608 0,09433187 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,05649376 0,09429293 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,05649376 0,09422455 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05649376 0,09415627 ! cGMP metabolic process GO:0046068 16 13 0,000 0,05649376 0,09408809 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,05649376 0,09402001 ! water transport GO:0006833 17 13 0,000 0,05649376 0,09395203 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05649376 0,09388415 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05649376 0,09381636 ! lipid localization GO:0010876 24 13 0,000 0,05649376 0,09374867 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,05649376 0,09368108 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,05649376 0,09361359 ! organelle fusion GO:0048284 28 13 0,000 0,05649376 0,09354619 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05649376 0,09347889 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,05649376 0,09341169 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,05649376 0,09334458 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05649376 0,09327757 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05649376 0,09321066 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05649376 0,09314384 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05649376 0,09307712 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05649376 0,09301049 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05649376 0,09294396 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05649376 0,09287752 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05649376 0,09281118 ! NAD metabolic process GO:0019674 21 13 0,000 0,05649376 0,09274494 ! exocrine system development GO:0035272 27 13 0,000 0,05649376 0,09267879 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,05649376 0,09261273 ! bone mineralization GO:0030282 15 13 0,000 0,05649376 0,09254676 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05649376 0,09248089 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05649376 0,09241512 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05649376 0,09234944 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05649376 0,09228385 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,05649376 0,09221835 ! genitalia development GO:0048806 15 13 0,000 0,05649376 0,09215295 ! regulation of cellular pH GO:0030641 20 13 0,000 0,05649376 0,09208764 ! cellular pigmentation GO:0033059 24 13 0,000 0,05649376 0,09202242 ! tissue regeneration GO:0042246 21 13 0,000 0,05649376 0,09195729 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,05649376 0,09189226 ! cofactor transport GO:0051181 19 13 0,000 0,05649376 0,09182732 ! NADP metabolic process GO:0006739 18 13 0,000 0,05649376 0,09176247 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05649376 0,09169771 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05649376 0,09163304 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05649376 0,09156847 ! gas transport GO:0015669 18 13 0,000 0,05649376 0,09150398 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05649376 0,09143959 ! regulation of axon extension GO:0030516 23 13 0,000 0,05649376 0,09137529 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05649376 0,09131107 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,05649376 0,09124695 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05649376 0,09118292 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05649376 0,09111897 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,05649376 0,09105512 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05649376 0,09099136 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,05764205 0,09277587 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,05764205 0,09271099 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,05881642 0,09453374 ! interphase GO:0051325 159 88 1,000 0,05881642 0,09446772 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,05999911 0,09630003 ! regulation of T cell activation GO:0050863 128 89 1,000 0,05999911 0,09623288 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,06070657 0,09729973 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,06070657 0,09723197 ! superoxide anion generation GO:0042554 18 14 0,000 0,06070657 0,09716431 ! neuron maturation GO:0042551 21 14 0,000 0,06070657 0,09709674 ! myotube differentiation GO:0014902 21 14 0,000 0,06070657 0,09702926 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,06070657 0,09696188 ! inositol metabolic process GO:0006020 20 14 0,000 0,06070657 0,09689459 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,06070657 0,0968274 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,06070657 0,0967603 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,06070657 0,09669329 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,06070657 0,09662637 ! gene silencing by RNA GO:0031047 20 14 0,000 0,06070657 0,09655955 ! response to cAMP GO:0051591 19 14 0,000 0,06070657 0,09649282 ! limbic system development GO:0021761 25 14 0,000 0,06070657 0,09642618 ! startle response GO:0001964 21 14 0,000 0,06070657 0,09635963 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,06070657 0,09629318 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,06070657 0,09622681 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,06070657 0,09616054 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,06070657 0,09609436 ! glycine metabolic process GO:0006544 22 14 0,000 0,06070657 0,09602827 ! pituitary gland development GO:0021983 23 14 0,000 0,06070657 0,09596227 ! cellular response to starvation GO:0009267 21 14 0,000 0,06070657 0,09589637 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,06070657 0,09583055 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,06070657 0,09576482 ! regulation of heart rate GO:0002027 23 14 0,000 0,06070657 0,09569918 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,06070657 0,09563364 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,06070657 0,09556818 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,06070657 0,09550281 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,06070657 0,09543753 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,06070657 0,09537234 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,06070657 0,09530724 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,06070657 0,09524223 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,06070657 0,09517731 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,06070657 0,09511247 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,06070657 0,09504773 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06070657 0,09498307 ! mRNA splice site selection GO:0006376 26 14 0,000 0,06070657 0,0949185 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,06070657 0,09485401 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,06070657 0,09478962 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,06070657 0,09472531 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,06070657 0,09466109 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,06070657 0,09459696 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,06070657 0,09453291 ! muscle maintenance GO:0046716 19 14 0,000 0,06070657 0,09446895 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,06070657 0,09440508 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,06070657 0,09434129 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,06070657 0,09427759 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,06070657 0,09421397 ! cell killing GO:0001906 20 14 0,000 0,06070657 0,09415044 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,06070657 0,094087 ! cilium assembly GO:0042384 20 14 0,000 0,06070657 0,09402364 ! peptide hormone secretion GO:0030072 23 14 0,000 0,06070657 0,09396037 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,06119001 0,09464493 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,06359606 0,09830036 ! cell fate commitment GO:0045165 141 92 1,000 0,06359606 0,09823434 ! sulfur metabolic process GO:0006790 118 92 1,000 0,06359606 0,09816841 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,06481103 0,09997677 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,06481103 0,09990977 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,0649008 0,09998114 ! metencephalon development GO:0022037 19 15 0,000 0,0649008 0,09991422 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,0649008 0,09984739 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,0649008 0,09978065 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,0649008 0,09971399 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,0649008 0,09964743 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,0649008 0,09958095 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,0649008 0,09951456 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,0649008 0,09944827 ! bile acid metabolic process GO:0008206 22 15 0,000 0,0649008 0,09938206 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,0649008 0,09931593 ! adult walking behavior GO:0007628 25 15 0,000 0,0649008 0,0992499 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,0649008 0,09918395 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,0649008 0,09911809 ! myoblast differentiation GO:0045445 27 15 0,000 0,0649008 0,09905232 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,0649008 0,09898664 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,0649008 0,09892104 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,0649008 0,09885553 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,0649008 0,0987901 ! cerebral cortex development GO:0021987 29 15 0,000 0,0649008 0,09872477 ! response to osmotic stress GO:0006970 22 15 0,000 0,0649008 0,09865952 ! vesicle coating GO:0006901 25 15 0,000 0,0649008 0,09859435 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,0649008 0,09852927 ! DNA integration GO:0015074 22 15 0,000 0,0649008 0,09846428 ! peptide secretion GO:0002790 27 15 0,000 0,0649008 0,09839937 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,0649008 0,09833455 ! regulation of vasodilation GO:0042312 24 15 0,000 0,0649008 0,09826981 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,0649008 0,09820516 ! neuron recognition GO:0008038 22 15 0,000 0,0649008 0,0981406 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,0649008 0,09807612 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,0649008 0,09801172 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,0649008 0,09794741 ! biomineral formation GO:0031214 18 15 0,000 0,0649008 0,09788318 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,0649008 0,09781903 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,0649008 0,09775498 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,0649008 0,097691 ! dopamine metabolic process GO:0042417 30 15 0,000 0,0649008 0,09762711 ! organic cation transport GO:0015695 19 15 0,000 0,0649008 0,0975633 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,0649008 0,09749957 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,0649008 0,09743593 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,0649008 0,09737237 ! defense response to virus GO:0051607 27 15 0,000 0,0649008 0,0973089 ! peptide hormone processing GO:0016486 19 15 0,000 0,0649008 0,0972455 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,0649008 0,09718219 ! electron transport chain GO:0022900 123 94 1,000 0,06603384 0,09881446 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,0685026 0,10244213 ! protein secretion GO:0009306 27 16 0,000 0,06907655 0,10323331 ! hormone secretion GO:0046879 25 16 0,000 0,06907655 0,10316627 ! bone remodeling GO:0046849 24 16 0,000 0,06907655 0,10309933 ! endothelial cell migration GO:0043542 22 16 0,000 0,06907655 0,10303246 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06907655 0,10296569 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06907655 0,102899 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06907655 0,1028324 ! glial cell development GO:0021782 24 16 0,000 0,06907655 0,10276589 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06907655 0,10269946 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06907655 0,10263311 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06907655 0,10256686 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06907655 0,10250068 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,06907655 0,1024346 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,06907655 0,1023686 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,06907655 0,10230268 ! fructose metabolic process GO:0006000 20 16 0,000 0,06907655 0,10223685 ! regulation of protein binding GO:0043393 27 16 0,000 0,06907655 0,1021711 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,06907655 0,10210544 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06907655 0,10203986 ! protein export from nucleus GO:0006611 24 16 0,000 0,06907655 0,10197437 ! negative regulation of immune response GO:0050777 28 16 0,000 0,06907655 0,10190895 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06907655 0,10184363 ! DNA replication initiation GO:0006270 25 16 0,000 0,06907655 0,10177839 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,06907655 0,10171323 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06907655 0,10164815 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06907655 0,10158316 ! diencephalon development GO:0021536 25 16 0,000 0,06907655 0,10151825 ! neural crest cell migration GO:0001755 24 16 0,000 0,06907655 0,10145342 ! G1 phase GO:0051318 27 16 0,000 0,06907655 0,10138868 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,06907655 0,10132402 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06907655 0,10125944 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,06907655 0,10119494 ! steroid catabolic process GO:0006706 22 16 0,000 0,06907655 0,10113053 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,06907655 0,1010662 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06907655 0,10100195 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06907655 0,10093778 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06907655 0,10087369 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,06907655 0,10080968 ! nerve development GO:0021675 18 16 0,000 0,06907655 0,10074576 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06907655 0,10068191 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,06907655 0,10061815 ! negative regulation of translation GO:0017148 22 16 0,000 0,06907655 0,10055447 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,06974838 0,10146823 ! extracellular structure organization GO:0043062 156 99 1,000 0,07226226 0,10505891 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,07323388 0,10640425 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,07323388 0,10633708 ! negative regulation of defense response GO:0031348 19 17 0,000 0,07323388 0,10626999 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,07323388 0,10620298 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,07323388 0,10613606 ! glycerol metabolic process GO:0006071 20 17 0,000 0,07323388 0,10606923 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,07323388 0,10600248 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,07323388 0,10593581 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,07323388 0,10586922 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,07323388 0,10580272 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,07323388 0,1057363 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,07323388 0,10566997 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,07323388 0,10560372 ! memory GO:0007613 25 17 0,000 0,07323388 0,10553755 ! keratinization GO:0031424 17 17 0,000 0,07323388 0,10547147 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,07323388 0,10540547 ! retinoid metabolic process GO:0001523 22 17 0,000 0,07323388 0,10533955 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,07323388 0,10527371 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,07323388 0,10520795 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,07323388 0,10514228 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,07323388 0,10507669 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,07323388 0,10501118 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,07323388 0,10494575 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,07323388 0,10488041 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,07323388 0,10481514 ! membrane budding GO:0006900 29 17 0,000 0,07323388 0,10474996 ! heme metabolic process GO:0042168 27 17 0,000 0,07323388 0,10468486 ! actin filament bundle formation GO:0051017 26 17 0,000 0,07323388 0,10461983 ! body fluid secretion GO:0007589 27 17 0,000 0,07323388 0,10455489 ! stem cell differentiation GO:0048863 36 17 0,000 0,07323388 0,10449003 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,07323388 0,10442525 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,07323388 0,10436055 ! sensory perception of pain GO:0019233 23 17 0,000 0,07323388 0,10429593 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,07323388 0,10423139 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,07323388 0,10416693 ! synaptogenesis GO:0007416 24 17 0,000 0,07323388 0,10410255 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,07323388 0,10403825 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,07323388 0,10397403 ! cell-cell junction organization GO:0045216 25 17 0,000 0,07323388 0,10390989 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,07323388 0,10384583 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,07323388 0,10378184 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,07323388 0,10371794 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,07323388 0,10365411 ! positive regulation of translation GO:0045727 28 18 0,000 0,07737289 0,10944505 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,07737289 0,10937778 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,07737289 0,1093106 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,07737289 0,10924349 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,07737289 0,10917647 ! cAMP metabolic process GO:0046058 33 18 0,000 0,07737289 0,10910953 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,07737289 0,10904268 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,07737289 0,1089759 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,07737289 0,10890921 ! axis specification GO:0009798 26 18 0,000 0,07737289 0,1088426 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,07737289 0,10877607 ! pancreas development GO:0031016 26 18 0,000 0,07737289 0,10870962 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,07737289 0,10864325 ! glutamine metabolic process GO:0006541 23 18 0,000 0,07737289 0,10857697 ! pigmentation during development GO:0048066 31 18 0,000 0,07737289 0,10851076 ! central nervous system neuron development GO:0021954 30 18 0,000 0,07737289 0,10844464 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,07737289 0,10837859 ! fucose metabolic process GO:0006004 26 18 0,000 0,07737289 0,10831263 ! response to fungus GO:0009620 19 18 0,000 0,07737289 0,10824675 ! peptide cross-linking GO:0018149 31 18 0,000 0,07737289 0,10818094 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,07737289 0,10811522 ! heart process GO:0003015 27 18 0,000 0,07737289 0,10804957 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,07737289 0,10798401 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,07737289 0,10791853 ! somitogenesis GO:0001756 24 18 0,000 0,07737289 0,10785312 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,07737289 0,10778779 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,07737289 0,10772255 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,07737289 0,10765738 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,07737289 0,10759229 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,07737289 0,10752728 ! vitamin transport GO:0051180 24 18 0,000 0,07737289 0,10746235 ! hormone transport GO:0009914 27 18 0,000 0,07737289 0,1073975 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,07737289 0,10733272 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,07737289 0,10726802 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,07737289 0,1072034 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,07737289 0,10713886 ! cell-cell recognition GO:0009988 20 18 0,000 0,07737289 0,1070744 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,07737289 0,10701001 ! regulation of glucose import GO:0046324 21 18 0,000 0,07737289 0,1069457 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,07737289 0,10688147 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,07737289 0,10681732 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,07737289 0,10675324 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,08149365 0,11237134 ! positive regulation of ossification GO:0045778 30 19 0,000 0,08149365 0,11230401 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,08149365 0,11223676 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,08149365 0,11216959 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,08149365 0,11210251 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,08149365 0,1120355 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,08149365 0,11196857 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,08149365 0,11190173 ! regeneration GO:0031099 32 19 0,000 0,08149365 0,11183496 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,08149365 0,11176827 ! response to alkaloid GO:0043279 32 19 0,000 0,08149365 0,11170166 ! sensory perception of taste GO:0050909 23 19 0,000 0,08149365 0,11163514 ! smooth muscle contraction GO:0006939 36 19 0,000 0,08149365 0,11156869 ! peroxisome organization GO:0007031 29 19 0,000 0,08149365 0,11150232 ! digestive system process GO:0022600 30 19 0,000 0,08149365 0,11143602 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,08149365 0,11136981 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,08149365 0,11130368 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,08149365 0,11123762 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,08149365 0,11117164 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,08149365 0,11110575 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,08149365 0,11103992 ! response to starvation GO:0042594 30 19 0,000 0,08149365 0,11097418 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,08149365 0,11090852 ! plasma membrane fusion GO:0045026 23 19 0,000 0,08149365 0,11084293 ! cytolysis GO:0019835 20 19 0,000 0,08149365 0,11077742 ! vasodilation GO:0042311 33 19 0,000 0,08149365 0,11071199 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,08149365 0,11064663 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,08149365 0,11058135 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,08149365 0,11051615 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,08149365 0,11045103 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,08149365 0,11038598 ! sarcomere organization GO:0045214 23 19 0,000 0,08149365 0,11032101 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,08149365 0,11025611 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,08149365 0,11019129 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,08149365 0,11012655 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,08149365 0,11006189 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,08149365 0,1099973 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,08149365 0,10993278 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,08149365 0,10986834 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,08559624 0,11533178 ! iron ion transport GO:0006826 37 20 0,000 0,08559624 0,11526425 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,08559624 0,11519681 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,08559624 0,11512944 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,08559624 0,11506215 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,08559624 0,11499494 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,08559624 0,11492781 ! spinal cord development GO:0021510 31 20 0,000 0,08559624 0,11486076 ! response to ethanol GO:0045471 37 20 0,000 0,08559624 0,11479379 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,08559624 0,11472689 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,08559624 0,11466007 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,08559624 0,11459333 ! chromosome condensation GO:0030261 31 20 0,000 0,08559624 0,11452667 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,08559624 0,11446008 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,08559624 0,11439358 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,08559624 0,11432715 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,08559624 0,11426079 ! pallium development GO:0021543 38 20 0,000 0,08559624 0,11419452 ! DNA modification GO:0006304 28 20 0,000 0,08559624 0,11412832 ! collagen fibril organization GO:0030199 45 20 0,000 0,08559624 0,11406219 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,08559624 0,11399615 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,08559624 0,11393018 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,08559624 0,11386428 ! collagen catabolic process GO:0030574 25 20 0,000 0,08559624 0,11379847 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,08559624 0,11373272 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,08559624 0,11366706 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,08559624 0,11360147 ! alditol metabolic process GO:0019400 24 20 0,000 0,08559624 0,11353595 ! actin filament-based movement GO:0030048 34 20 0,000 0,08559624 0,11347052 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,08968073 0,11881664 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,08968073 0,11874824 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,08968073 0,11867991 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,08968073 0,11861167 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,08968073 0,1185435 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,08968073 0,11847541 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,08968073 0,1184074 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,08968073 0,11833947 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,08968073 0,11827161 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,08968073 0,11820383 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,08968073 0,11813613 ! vesicle docking GO:0048278 27 21 0,000 0,08968073 0,11806851 ! phototransduction GO:0007602 25 21 0,000 0,08968073 0,11800097 ! dendrite development GO:0016358 35 21 0,000 0,08968073 0,1179335 ! visual behavior GO:0007632 39 21 0,000 0,08968073 0,11786611 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,08968073 0,11779879 ! ovarian follicle development GO:0001541 30 21 0,000 0,08968073 0,11773156 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,08968073 0,1176644 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,08968073 0,11759731 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,08968073 0,11753031 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,08968073 0,11746338 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,08968073 0,11739652 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,08968073 0,11732974 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,08968073 0,11726304 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,08968073 0,11719641 ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,08968073 0,11712986 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,08968073 0,11706339 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,08968073 0,11699699 ! fatty acid transport GO:0015908 30 21 0,000 0,08968073 0,11693066 ! immunoglobulin production GO:0002377 33 21 0,000 0,08968073 0,11686441 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,08968073 0,11679824 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,08968073 0,11673214 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,08968073 0,11666611 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,08968073 0,11660016 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,08968073 0,11653429 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,08968073 0,11646849 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,08968073 0,11640276 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,08968073 0,11633711 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,08968073 0,11627153 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,08968073 0,11620602 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,08968073 0,11614059 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,08968073 0,11607523 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,08968073 0,11600995 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,08968073 0,11594474 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,09374722 0,12113405 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,09374722 0,12106603 ! viral genome replication GO:0019079 29 22 0,000 0,09374722 0,1209981 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,09374722 0,12093023 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,09374722 0,12086245 ! leukocyte adhesion GO:0007159 38 22 0,000 0,09374722 0,12079474 ! molting cycle process GO:0022404 40 22 0,000 0,09374722 0,1207271 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,09374722 0,12065954 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,09374722 0,12059206 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,09374722 0,12052465 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,09374722 0,12045732 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,09374722 0,12039006 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,09374722 0,12032288 ! lysosome organization GO:0007040 37 22 0,000 0,09374722 0,12025578 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,09374722 0,12018874 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,09374722 0,12012179 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,09374722 0,1200549 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,09374722 0,11998809 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,09374722 0,11992136 ! membrane depolarization GO:0051899 35 22 0,000 0,09374722 0,1198547 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,09374722 0,11978811 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,09374722 0,1197216 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,09374722 0,11965516 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,09374722 0,1195888 ! neural tube closure GO:0001843 33 22 0,000 0,09374722 0,11952251 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,09374722 0,11945629 ! neuron fate commitment GO:0048663 32 23 0,000 0,09779577 0,12454611 ! embryonic pattern specification GO:0009880 31 23 0,000 0,09779577 0,12447719 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,09779577 0,12440834 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,09779577 0,12433957 ! vesicle targeting GO:0006903 32 23 0,000 0,09779577 0,12427087 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,09779577 0,12420225 ! osteoblast differentiation GO:0001649 40 23 0,000 0,09779577 0,12413371 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,09779577 0,12406524 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,09779577 0,12399684 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,09779577 0,12392853 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,09779577 0,12386028 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,09779577 0,12379212 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,09779577 0,12372402 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,09779577 0,12365601 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,09779577 0,12358806 ! cell fate determination GO:0001709 45 23 0,000 0,09779577 0,12352019 ! pentose metabolic process GO:0019321 31 23 0,000 0,09779577 0,1234524 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,09779577 0,12338468 ! spermatid development GO:0007286 33 23 0,000 0,09779577 0,12331704 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,09779577 0,12324947 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,09779577 0,12318197 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,09779577 0,12311455 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,09779577 0,1230472 ! telomere organization GO:0032200 32 23 0,000 0,09779577 0,12297992 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,09779577 0,12291272 ! regulation of amine transport GO:0051952 38 23 0,000 0,09779577 0,12284559 ! liver development GO:0001889 40 23 0,000 0,09779577 0,12277853 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,10182647 0,12776916 ! initiation of viral infection GO:0019059 42 24 0,000 0,10182647 0,1276995 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,10182647 0,12762991 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,10182647 0,12756039 ! superoxide metabolic process GO:0006801 32 24 0,000 0,10182647 0,12749095 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,10182647 0,12742159 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,10182647 0,1273523 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,10182647 0,12728309 ! sperm motility GO:0030317 27 24 0,000 0,10182647 0,12721395 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,10182647 0,12714488 ! vacuole organization GO:0007033 39 24 0,000 0,10182647 0,1270759 ! neural crest cell development GO:0014032 39 24 0,000 0,10182647 0,12700698 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,10182647 0,12693814 ! primary neural tube formation GO:0014020 35 24 0,000 0,10182647 0,12686938 ! negative regulation of cell development GO:0010721 56 24 0,000 0,10182647 0,12680069 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,10182647 0,12673208 ! base-excision repair GO:0006284 31 24 0,000 0,10182647 0,12666354 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,10182647 0,12659507 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,10182647 0,12652668 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,10182647 0,12645836 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,10182647 0,12639011 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,10182647 0,12632194 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,10583939 0,13122943 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,10583939 0,13115872 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,10583939 0,13108809 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,10583939 0,13101754 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,10583939 0,13094706 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,10583939 0,13087666 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,10583939 0,13080634 ! peptide transport GO:0015833 43 25 0,000 0,10583939 0,13073608 ! male gonad development GO:0008584 33 25 0,000 0,10583939 0,13066591 ! iron ion homeostasis GO:0055072 39 25 0,000 0,10583939 0,13059581 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,10583939 0,13052579 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,10583939 0,13045584 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,10583939 0,13038596 ! phospholipid transport GO:0015914 35 25 0,000 0,10583939 0,13031616 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,10583939 0,13024644 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,10583939 0,13017679 ! detection of light stimulus GO:0009583 30 25 0,000 0,10583939 0,13010721 ! leukocyte proliferation GO:0070661 39 25 0,000 0,10583939 0,13003771 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,10983461 0,13487432 ! translational initiation GO:0006413 43 26 0,000 0,10983461 0,13480234 ! regulation of pH GO:0006885 36 26 0,000 0,10983461 0,13473045 ! circadian rhythm GO:0007623 42 26 0,000 0,10983461 0,13465863 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,10983461 0,13458689 ! post-embryonic development GO:0009791 42 26 0,000 0,10983461 0,13451522 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,10983461 0,13444364 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,10983461 0,13437212 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,10983461 0,13430069 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,10983461 0,13422933 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,10983461 0,13415804 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,10983461 0,13408683 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,10983461 0,1340157 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,1138122 0,13879537 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,1138122 0,13872181 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,1138122 0,13864834 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,1138122 0,13857494 ! membrane docking GO:0022406 39 27 0,000 0,1138122 0,13850162 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,1138122 0,13842838 ! catechol metabolic process GO:0009712 43 27 0,000 0,1138122 0,13835521 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,1138122 0,13828212 ! acute-phase response GO:0006953 42 27 0,000 0,1138122 0,13820911 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,1138122 0,13813618 ! myofibril assembly GO:0030239 36 27 0,000 0,1138122 0,13806332 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,1138122 0,13799054 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,1138122 0,13791784 ! natural killer cell activation GO:0030101 35 27 0,000 0,1138122 0,13784521 ! lipid oxidation GO:0034440 38 27 0,000 0,1138122 0,13777266 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,1138122 0,13770019 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,1138122 0,13762779 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,1138122 0,13755547 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,11777225 0,1422669 ! phenol metabolic process GO:0018958 44 28 0,000 0,11777225 0,14219222 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,11777225 0,14211761 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,11777225 0,14204309 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,11777225 0,14196864 ! cell junction assembly GO:0034329 56 28 0,000 0,11777225 0,14189428 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,11777225 0,14181999 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,11777225 0,14174577 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,11777225 0,14167164 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,11777225 0,14159758 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,11777225 0,1415236 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,11777225 0,1414497 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,11777225 0,14137587 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,11777225 0,14130212 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,11777225 0,14122845 ! mesoderm formation GO:0001707 46 28 0,000 0,11777225 0,14115486 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,11777225 0,14108134 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,11777225 0,1410079 ! BMP signaling pathway GO:0030509 40 28 0,000 0,11777225 0,14093453 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,11777225 0,14086124 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,11777225 0,14078803 ! neural tube formation GO:0001841 41 28 0,000 0,11777225 0,1407149 ! placenta development GO:0001890 37 28 0,000 0,11777225 0,14064183 ! regulation of B cell activation GO:0050864 42 28 0,000 0,11777225 0,14056885 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,12171483 0,14519922 ! regulation of innate immune response GO:0045088 38 29 0,000 0,12171483 0,14512395 ! ovulation cycle process GO:0022602 41 29 0,000 0,12171483 0,14504876 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,12171483 0,14497364 ! protein targeting to membrane GO:0006612 53 29 0,000 0,12171483 0,1448986 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,12171483 0,14482364 ! mismatch repair GO:0006298 34 29 0,000 0,12171483 0,14474876 ! muscle cell development GO:0055001 38 29 0,000 0,12171483 0,14467396 ! formation of primary germ layer GO:0001704 48 29 0,000 0,12171483 0,14459923 ! telencephalon development GO:0021537 52 29 0,000 0,12171483 0,14452458 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,12171483 0,14445 ! eye morphogenesis GO:0048592 51 29 0,000 0,12171483 0,1443755 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,12171483 0,14430108 ! collagen metabolic process GO:0032963 40 30 0,000 0,12564001 0,14887791 ! organic anion transport GO:0015711 51 30 0,000 0,12564001 0,14880125 ! cholesterol transport GO:0030301 46 30 0,000 0,12564001 0,14872467 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,12564001 0,14864816 ! spliceosome assembly GO:0000245 49 30 0,000 0,12564001 0,14857174 ! spindle organization GO:0007051 37 30 0,000 0,12564001 0,14849539 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,12564001 0,14841912 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,12564001 0,14834293 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,12564001 0,14826682 ! ceramide metabolic process GO:0006672 43 30 0,000 0,12564001 0,14819078 ! ovulation cycle GO:0042698 43 30 0,000 0,12564001 0,14811483 ! hindbrain development GO:0030902 45 30 0,000 0,12564001 0,14803895 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,12564001 0,14796315 ! adult locomotory behavior GO:0008344 47 30 0,000 0,12564001 0,14788742 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,12564001 0,14781178 ! response to heat GO:0009408 41 30 0,000 0,12564001 0,14773621 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,12564001 0,14766072 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,12564001 0,14758531 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,12954788 0,15209807 ! glial cell differentiation GO:0010001 55 31 0,000 0,12954788 0,15202047 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,12954788 0,15194295 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,12954788 0,1518655 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,12954788 0,15178814 ! odontogenesis GO:0042476 50 31 0,000 0,12954788 0,15171086 ! segmentation GO:0035282 41 31 0,000 0,12954788 0,15163365 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,12954788 0,15155652 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,12954788 0,15147947 ! metanephros development GO:0001656 58 31 0,000 0,12954788 0,1514025 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,12954788 0,15132561 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,12954788 0,15124879 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,12954788 0,15117205 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,12954788 0,1510954 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,12954788 0,15101881 ! RNA modification GO:0009451 40 31 0,000 0,12954788 0,15094231 ! regulation of muscle development GO:0048634 48 32 0,000 0,1334385 0,15539674 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,1334385 0,15531809 ! meiosis I GO:0007127 52 32 0,000 0,1334385 0,15523953 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,1334385 0,15516105 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,1334385 0,15508264 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,1334385 0,15500432 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,1334385 0,15492607 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,1334385 0,15484791 ! cytokine production GO:0001816 44 32 0,000 0,1334385 0,15476982 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,1334385 0,15469181 ! vesicle localization GO:0051648 47 32 0,000 0,1334385 0,15461388 ! RNA export from nucleus GO:0006405 44 33 0,000 0,13731196 0,1590219 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,13731196 0,15894187 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,13731196 0,15886192 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,13731196 0,15878205 ! sister chromatid segregation GO:0000819 46 33 0,000 0,13731196 0,15870226 ! ear morphogenesis GO:0042471 42 33 0,000 0,13731196 0,15862255 ! actomyosin structure organization GO:0031032 43 33 0,000 0,13731196 0,15854292 ! cell junction organization GO:0034330 63 33 0,000 0,13731196 0,15846337 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,13731196 0,1583839 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,13731196 0,15830451 ! nucleus organization GO:0006997 49 33 0,000 0,13731196 0,1582252 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,13731196 0,15814597 ! positive regulation of cell development GO:0010720 54 33 0,000 0,13731196 0,15806682 ! lipid homeostasis GO:0055088 55 33 0,000 0,13731196 0,15798774 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,13731196 0,15790875 ! regulation of proteolysis GO:0030162 50 33 0,000 0,13731196 0,15782984 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,13731196 0,157751 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,13731196 0,15767224 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,13731196 0,15759356 ! mRNA catabolic process GO:0006402 48 34 0,000 0,14116832 0,16193872 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,14116832 0,16185799 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,14116832 0,16177735 ! feeding behavior GO:0007631 45 34 0,000 0,14116832 0,16169678 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,14116832 0,16161629 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,14116832 0,16153589 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,14116832 0,16145556 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,14116832 0,16137532 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,14116832 0,16129515 ! neuron migration GO:0001764 46 34 0,000 0,14116832 0,16121506 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,14116832 0,16113505 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,14116832 0,16105513 ! polyol metabolic process GO:0019751 44 34 0,000 0,14116832 0,16097528 ! aerobic respiration GO:0009060 47 34 0,000 0,14116832 0,16089551 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,14116832 0,16081582 ! embryonic organ development GO:0048568 45 34 0,000 0,14116832 0,1607362 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,14116832 0,16065667 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,14500766 0,16494442 ! Notch signaling pathway GO:0007219 56 35 0,000 0,14500766 0,16486289 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,14500766 0,16478144 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,14500766 0,16470006 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,14500766 0,16461877 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,14500766 0,16453756 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,14500766 0,16445642 ! pigment metabolic process GO:0042440 61 35 0,000 0,14500766 0,16437537 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,14500766 0,1642944 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,14500766 0,1642135 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,14883006 0,16845922 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,14883006 0,16837636 ! organic ether metabolic process GO:0018904 46 36 0,000 0,14883006 0,16829358 ! neural tube development GO:0021915 50 36 0,000 0,14883006 0,16821088 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,14883006 0,16812826 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,14883006 0,16804573 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,14883006 0,16796327 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,15263559 0,17217355 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,15263559 0,17208915 ! learning GO:0007612 67 37 0,000 0,15263559 0,17200483 ! ion transmembrane transport GO:0034220 56 37 0,000 0,15263559 0,1719206 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,15263559 0,17183645 ! amino acid activation GO:0043038 52 37 0,000 0,15263559 0,17175238 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,15263559 0,17166839 ! gliogenesis GO:0042063 71 38 0,000 0,15642432 0,17584357 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,15642432 0,17575767 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,15642432 0,17567185 ! phagocytosis GO:0006909 60 38 0,000 0,15642432 0,17558611 ! mesenchymal cell development GO:0014031 64 38 0,000 0,15642432 0,17550046 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,15642432 0,17541489 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,16019633 0,17955729 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,16019633 0,17946983 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,16019633 0,17938245 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,16019633 0,17929516 ! male sex differentiation GO:0046661 53 39 0,000 0,16019633 0,17920796 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,16019633 0,17912084 ! chromatin remodeling GO:0006338 68 39 0,000 0,16019633 0,1790338 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,16019633 0,17894685 ! JNK cascade GO:0007254 54 39 0,000 0,16019633 0,17885998 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,16395169 0,18296404 ! response to calcium ion GO:0051592 58 40 0,000 0,16395169 0,18287531 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,16395169 0,18278666 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,16395169 0,1826981 ! peptide metabolic process GO:0006518 56 40 0,000 0,16395169 0,18260963 ! inner ear development GO:0048839 57 40 0,000 0,16395169 0,18252124 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,16395169 0,18243294 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,16395169 0,18234472 ! B cell differentiation GO:0030183 62 40 0,000 0,16395169 0,18225659 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,16395169 0,18216854 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,16769047 0,18623277 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,16769047 0,18614289 ! striated muscle contraction GO:0006941 62 41 0,000 0,16769047 0,1860531 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,16769047 0,18596339 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,16769047 0,18587377 ! mitochondrial transport GO:0006839 60 42 0,000 0,17141274 0,18990814 ! cellular component disassembly GO:0022411 64 42 0,000 0,17141274 0,1898167 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,17141274 0,18972536 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,17141274 0,1896341 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,17141274 0,18954293 ! excretion GO:0007588 63 42 0,000 0,17141274 0,18945185 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,17141274 0,18936085 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,17141274 0,18926995 ! leukocyte migration GO:0050900 60 43 0,000 0,17511857 0,19326906 ! neuromuscular process GO:0050905 79 43 0,000 0,17511857 0,19317637 ! activation of caspase activity GO:0006919 65 43 0,000 0,17511857 0,19308376 ! tRNA processing GO:0008033 49 43 0,000 0,17511857 0,19299124 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,17511857 0,19289881 ! vesicle organization GO:0016050 79 43 0,000 0,17511857 0,19280647 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,17511857 0,19271422 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,17880805 0,1966803 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,17880805 0,19658629 ! glycolysis GO:0006096 53 44 0,000 0,17880805 0,19649236 ! regulation of ion transport GO:0043269 57 44 0,000 0,17880805 0,19639853 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,17880805 0,19630478 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,17880805 0,19621112 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,17880805 0,19611756 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,17880805 0,19602408 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,17880805 0,19593069 ! RNA catabolic process GO:0006401 64 45 0,000 0,18248123 0,1998604 ! regulation of translational initiation GO:0006446 64 45 0,000 0,18248123 0,19976527 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,18248123 0,19967024 ! cell recognition GO:0008037 58 45 0,000 0,18248123 0,19957529 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,1861382 0,20347807 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,1861382 0,2033814 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,1861382 0,20328483 ! regulation of ossification GO:0030278 71 46 0,000 0,1861382 0,20318835 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,1861382 0,20309196 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,18977901 0,2069662 ! viral infectious cycle GO:0019058 71 47 0,000 0,18977901 0,20686811 ! endocrine system development GO:0035270 83 47 0,000 0,18977901 0,20677012 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,18977901 0,20667222 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,18977901 0,20657441 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,18977901 0,20647669 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,18977901 0,20637906 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,18977901 0,20628153 ! chloride transport GO:0006821 67 48 0,000 0,19340374 0,21012216 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,19340374 0,21002295 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,19340374 0,20992384 ! response to temperature stimulus GO:0009266 62 48 0,000 0,19340374 0,20982482 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,19340374 0,20972589 ! gastrulation GO:0007369 73 48 0,000 0,19340374 0,20962705 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,19340374 0,20952831 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,19340374 0,20942967 ! regulation of endocytosis GO:0030100 63 48 0,000 0,19340374 0,20933111 ! nuclear export GO:0051168 69 48 0,000 0,19340374 0,20923265 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,19701247 0,21303652 ! sensory perception of smell GO:0007608 61 49 0,000 0,19701247 0,21293641 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,19701247 0,21283639 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,19701247 0,21273647 ! RNA elongation GO:0006354 62 49 0,000 0,19701247 0,21263664 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,19701247 0,2125369 ! cartilage development GO:0051216 70 49 0,000 0,19701247 0,21243726 ! regulation of actin filament length GO:0030832 72 50 0,000 0,20060525 0,21620997 ! ear development GO:0043583 72 50 0,000 0,20060525 0,2161087 ! membrane fusion GO:0006944 80 50 0,000 0,20060525 0,21600753 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,20060525 0,21590645 ! proton transport GO:0015992 75 50 0,000 0,20060525 0,21580546 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,20060525 0,21570457 ! positive regulation of secretion GO:0051047 71 51 0,000 0,20418217 0,21944813 ! hydrogen transport GO:0006818 77 51 0,000 0,20418217 0,21934563 ! adult behavior GO:0030534 80 51 0,000 0,20418217 0,21924323 ! transition metal ion transport GO:0000041 74 52 0,000 0,20774328 0,22296293 ! regulation of cellular component size GO:0032535 74 52 0,000 0,20774328 0,22285893 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,20774328 0,22275504 ! establishment of organelle localization GO:0051656 85 52 0,000 0,20774328 0,22265124 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,21128867 0,22634557 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,21128867 0,22624019 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,21128867 0,22613492 ! single fertilization GO:0007338 59 53 0,000 0,21128867 0,22602974 ! amino acid transport GO:0006865 84 54 0,000 0,21481839 0,22969888 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,21481839 0,22959214 ! glucose catabolic process GO:0006007 66 54 0,000 0,21481839 0,2294855 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,21481839 0,22937896 ! DNA catabolic process GO:0006308 67 54 0,000 0,21481839 0,22927252 ! detection of external stimulus GO:0009581 66 54 0,000 0,21481839 0,22916618 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,21481839 0,22905994 ! exocytosis GO:0006887 74 55 0,000 0,21833251 0,23269915 ! mesoderm development GO:0007498 76 55 0,000 0,21833251 0,23259137 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,21833251 0,23248369 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,21833251 0,23237611 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,22183111 0,23599054 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,22531425 0,23958519 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,22531425 0,23947448 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,22531425 0,23936387 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,22531425 0,23925336 ! camera-type eye development GO:0043010 88 57 0,000 0,22531425 0,23914295 ! secondary metabolic process GO:0019748 84 57 0,000 0,22531425 0,23903264 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,22878199 0,24259962 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,22878199 0,24248783 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,23223442 0,2460337 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,23567158 0,24956015 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,23567158 0,2494453 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,23567158 0,24933056 ! regulation of heart contraction GO:0008016 91 60 0,000 0,23567158 0,24921592 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,23567158 0,2491014 ! fertilization GO:0009566 68 60 0,000 0,23567158 0,24898697 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,23909355 0,25248631 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,23909355 0,25237043 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,23909355 0,25225467 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,23909355 0,25213901 ! extracellular matrix organization GO:0030198 103 61 0,000 0,23909355 0,25202345 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,23909355 0,251908 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,23909355 0,25179266 ! amine catabolic process GO:0009310 90 62 0,000 0,2425004 0,25526358 ! neurotransmitter transport GO:0006836 81 62 0,000 0,2425004 0,25514681 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,2425004 0,25503014 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,2425004 0,25491359 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,2425004 0,25479713 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,2425004 0,25468079 ! organelle localization GO:0051640 96 62 0,000 0,2425004 0,25456455 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,24926899 0,26155049 ! negative regulation of cell size GO:0045792 108 64 0,000 0,24926899 0,26143122 ! appendage morphogenesis GO:0035107 93 64 0,000 0,24926899 0,26131207 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,24926899 0,26119302 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,24926899 0,26107408 ! hexose catabolic process GO:0019320 82 64 0,000 0,24926899 0,26095524 ! appendage development GO:0048736 94 65 0,000 0,25263086 0,2643544 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,25263086 0,26423418 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,25263086 0,26411408 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,25263086 0,26399408 ! defense response to bacterium GO:0042742 73 65 0,000 0,25263086 0,26387419 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,25263086 0,26375441 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,25263086 0,26363474 ! activation of immune response GO:0002253 83 65 0,000 0,25263086 0,26351518 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,25597786 0,26688535 ! antigen processing and presentation GO:0019882 96 66 0,000 0,25597786 0,26676442 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,25597786 0,26664361 ! regulation of immune effector process GO:0002697 101 66 0,000 0,25597786 0,2665229 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,25931007 0,26987021 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,25931007 0,26974815 ! acute inflammatory response GO:0002526 92 68 0,000 0,26262754 0,27307565 ! learning or memory GO:0007611 123 68 0,000 0,26262754 0,27295226 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,26262754 0,27282897 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,26262754 0,2727058 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,26262754 0,27258274 ! rhythmic process GO:0048511 105 68 0,000 0,26262754 0,27245979 ! inorganic anion transport GO:0015698 93 68 0,000 0,26262754 0,27233695 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,26593035 0,27563758 ! response to drug GO:0042493 108 69 0,000 0,26593035 0,27551342 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,26593035 0,27538937 ! response to metal ion GO:0010038 103 70 0,000 0,26921855 0,27866906 ! humoral immune response GO:0006959 86 70 0,000 0,26921855 0,27854371 ! eye development GO:0001654 111 70 0,000 0,26921855 0,27841846 ! amine transport GO:0015837 101 70 0,000 0,26921855 0,27829333 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,27249221 0,2815508 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,27249221 0,28142437 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,27249221 0,28129806 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,27249221 0,28117186 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,27249221 0,28104577 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,27575139 0,28427978 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,27575139 0,28415242 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,27899616 0,28736729 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,28222657 0,29056451 ! digestion GO:0007586 97 74 0,000 0,28222657 0,2904345 ! protein import into nucleus GO:0006606 118 74 0,000 0,28222657 0,29030461 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,28222657 0,29017484 ! response to inorganic substance GO:0010035 115 75 0,000 0,2854427 0,2933504 ! negative regulation of growth GO:0045926 123 75 0,000 0,2854427 0,29321939 ! regulation of ligase activity GO:0051340 114 75 0,000 0,2854427 0,29308848 ! nuclear import GO:0051170 121 75 0,000 0,2854427 0,2929577 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,2854427 0,29282703 ! amine biosynthetic process GO:0009309 97 76 0,000 0,2886446 0,29597975 ! tRNA metabolic process GO:0006399 95 76 0,000 0,2886446 0,29584785 ! response to unfolded protein GO:0006986 99 76 0,000 0,2886446 0,29571607 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,29183233 0,29884878 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,29183233 0,29871578 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,29500597 0,30182995 ! cellular respiration GO:0045333 107 79 0,000 0,29816556 0,30492698 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,29816556 0,30479146 ! T cell activation GO:0042110 134 79 0,000 0,29816556 0,30465606 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,29816556 0,30452077 ! chromatin assembly GO:0031497 102 80 0,000 0,30131117 0,30759684 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,30131117 0,30746038 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,30131117 0,30732403 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,30131117 0,30718781 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,30131117 0,3070517 ! forebrain development GO:0030900 131 80 0,000 0,30131117 0,30691572 ! mRNA transport GO:0051028 121 81 0,000 0,30444286 0,30996839 ! response to protein stimulus GO:0051789 111 81 0,000 0,30444286 0,30983123 ! regulation of neurological system process GO:0031644 122 81 0,000 0,30444286 0,3096942 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,30444286 0,30955729 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 0,000 0,3075607 0,31258931 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,31066474 0,31560464 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,31375504 0,31860335 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,31683166 0,32158553 ! rRNA metabolic process GO:0016072 107 85 0,000 0,31683166 0,32144368 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,31683166 0,32130195 ! nucleosome organization GO:0034728 114 87 0,000 0,32294412 0,32735631 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,32294412 0,3272121 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,32294412 0,32706802 ! female pregnancy GO:0007565 130 87 0,000 0,32294412 0,32692406 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,32598007 0,32985225 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,32598007 0,32970719 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,32598007 0,32956227 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,32598007 0,32941747 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,32900258 0,33232584 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,32900258 0,33217995 ! leukocyte differentiation GO:0002521 143 90 0,000 0,33201171 0,33507105 ! hormone metabolic process GO:0042445 121 90 0,000 0,33201171 0,33492409 ! RNA localization GO:0006403 135 91 0,000 0,33500752 0,33779802 ! ATP metabolic process GO:0046034 137 91 0,000 0,33500752 0,33765 ! response to virus GO:0009615 122 91 0,000 0,33500752 0,3375021 ! positive regulation of immune response GO:0050778 121 92 0,000 0,33799006 0,34035777 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,3409594 0,34319764 ! response to oxidative stress GO:0006979 141 94 0,000 0,34391559 0,34602181 ! carboxylic acid transport GO:0046942 147 95 0,000 0,34685868 0,34883033 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,34978875 0,3516233 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,34978875 0,35146969 ! protein maturation GO:0051604 129 96 0,000 0,34978875 0,35131621 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,35270584 0,35409141 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,35850131 0,35975262 ! protein import GO:0017038 156 99 0,000 0,35850131 0,35959573 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,35850131 0,35943897 ! regulation of translation GO:0006417 151 100 0,000 0,3613798 0,36216712 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,3613798 0,36200938 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,3613798 0,36185178 ! divalent metal ion transport GO:0070838 171 100 0,000 0,3613798 0,36169432 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,3613798 0,36153699 ! protein localization in organelle GO:0033365 161 100 0,000 0,3613798 0,3613798