pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6659-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! sex determination GO:0007530 29 19 5,000 4,53E-09 1,042E-05 ! reproductive developmental process GO:0003006 127 89 7,000 4,049E-07 4,657E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 5,616E-07 4,306E-04 ! response to gamma radiation GO:0010332 20 12 3,000 1,558E-06 8,957E-04 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 3,000 3,113E-06 1,432E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 4,354E-06 1,669E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 5,000 4,772E-06 1,568E-03 ! negative regulation of kinase activity GO:0033673 100 58 5,000 5,29E-06 1,521E-03 ! negative regulation of transferase activity GO:0051348 105 61 5,000 7,121E-06 1,82E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 2,000 8,66E-06 1,992E-03 ! C21-steroid hormone metabolic process GO:0008207 23 19 3,000 1,17E-05 2,446E-03 ! positive regulation of inflammatory response GO:0050729 30 20 3,000 1,454E-05 2,786E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 1,507E-05 2,666E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,507E-05 2,476E-03 ! B cell lineage commitment GO:0002326 17 7 2,000 1,507E-05 2,311E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 1,507E-05 2,166E-03 ! cell aging GO:0007569 32 21 3,000 1,785E-05 2,415E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 2,398E-05 3,064E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,398E-05 2,902E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 2,61E-05 3,001E-03 ! response to UV GO:0009411 75 46 4,000 2,615E-05 2,864E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 3,113E-05 3,255E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 3,576E-05 3,576E-03 ! oocyte differentiation GO:0009994 12 9 2,000 3,576E-05 3,427E-03 GO:0048599|oocyte development, ! spleen development GO:0048536 15 9 2,000 3,576E-05 3,29E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 3,684E-05 3,259E-03 GO:0045936|negative regulation of phosphate metabolic process, ! response to ionizing radiation GO:0010212 47 27 3,000 5,051E-05 4,303E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 5,08E-05 4,173E-03 ! response to X-ray GO:0010165 16 10 2,000 5,08E-05 4,029E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 5,08E-05 3,895E-03 ! cell cycle arrest GO:0007050 150 86 5,000 5,156E-05 3,826E-03 ! DNA damage response, signal transduction GO:0042770 96 56 4,000 6,853E-05 4,926E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 6,946E-05 4,841E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 6,946E-05 4,699E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 6,946E-05 4,565E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 6,946E-05 4,438E-03 GO:0010829|negative regulation of glucose transport, ! response to peptide hormone stimulus GO:0043434 84 57 4,000 7,466E-05 4,641E-03 ! hindbrain development GO:0030902 45 30 3,000 7,748E-05 4,69E-03 ! DNA damage checkpoint GO:0000077 53 31 3,000 8,843E-05 5,215E-03 ! ribosomal large subunit biogenesis GO:0042273 12 12 2,000 9,21E-05 5,296E-03 ! histone acetylation GO:0016573 23 12 2,000 9,21E-05 5,166E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 9,21E-05 5,043E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 1,119E-04 5,986E-03 ! hormone biosynthetic process GO:0042446 45 33 3,000 1,137E-04 5,941E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 1,191E-04 6,085E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,191E-04 5,953E-03 ! DNA integrity checkpoint GO:0031570 57 34 3,000 1,28E-04 6,266E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 1,28E-04 6,135E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 1,302E-04 6,114E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,507E-04 6,931E-03 ! embryonic forelimb morphogenesis GO:0035115 17 15 2,000 1,873E-04 8,447E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,873E-04 8,284E-03 ! chromatin remodeling GO:0006338 68 39 3,000 2,205E-04 9,567E-03 ! protein amino acid acetylation GO:0006473 28 16 2,000 2,292E-04 9,763E-03 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 2,000 2,292E-04 9,586E-03 ! oogenesis GO:0048477 23 16 2,000 2,292E-04 9,415E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,292E-04 9,249E-03 ! negative regulation of transport GO:0051051 116 73 4,000 2,428E-04 9,63E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 2,435E-04 9,493E-03 ! T cell differentiation GO:0030217 65 40 3,000 2,435E-04 9,334E-03 ! negative regulation of growth GO:0045926 123 75 4,000 2,757E-04 0,01039346 ! signal complex assembly GO:0007172 29 17 2,000 2,768E-04 0,01026782 ! forelimb morphogenesis GO:0035136 19 17 2,000 2,768E-04 0,01010484 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,768E-04 9,947E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 2,768E-04 9,794E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 3,23E-04 0,01125728 ! response to insulin stimulus GO:0032868 63 43 3,000 3,23E-04 0,01108926 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 3,303E-04 0,01117135 ! regulation of glucose import GO:0046324 21 18 2,000 3,303E-04 0,01100944 GO:0010827|regulation of glucose transport, ! glycolysis GO:0006096 53 44 3,000 3,532E-04 0,0116065 ! regulation of inflammatory response GO:0050727 60 44 3,000 3,532E-04 0,01144303 ! alcohol catabolic process GO:0046164 104 80 4,000 3,724E-04 0,01189603 ! positive regulation of defense response GO:0031349 59 45 3,000 3,854E-04 0,01214325 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 3,9E-04 0,01212218 ! positive regulation of locomotion GO:0040017 35 20 2,000 4,563E-04 0,01399256 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of DNA replication GO:0006275 75 48 3,000 4,945E-04 0,01496455 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 5,201E-04 0,01553501 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 5,294E-04 0,01560906 ! protein amino acid acylation GO:0043543 37 21 2,000 5,294E-04 0,01541147 ! regulation of chemotaxis GO:0050920 36 21 2,000 5,294E-04 0,01521883 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 5,294E-04 0,01503094 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 5,294E-04 0,01484764 ! germ cell development GO:0007281 68 49 3,000 5,353E-04 0,01483252 ! integrin-mediated signaling pathway GO:0007229 81 49 3,000 5,353E-04 0,01465594 ! malate metabolic process GO:0006108 7 5 1,000 5,744E-04 0,01554305 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 5,744E-04 0,01536231 ! positive regulation of glycolysis GO:0045821 11 5 1,000 5,744E-04 0,01518574 ! microvillus organization GO:0032528 7 5 1,000 5,744E-04 0,01501317 GO:0030033|microvillus assembly, ! polyol catabolic process GO:0046174 7 5 1,000 5,744E-04 0,01484448 GO:0019405|alditol catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 5,744E-04 0,01467954 ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,744E-04 0,01451823 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 5,744E-04 0,01436042 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 5,744E-04 0,01420601 ! centrosome duplication GO:0051298 5 5 1,000 5,744E-04 0,01405488 ! response to UV-C GO:0010225 6 5 1,000 5,744E-04 0,01390694 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 5,744E-04 0,01376207 ! neural tube patterning GO:0021532 6 5 1,000 5,744E-04 0,0136202 ! regulation of respiratory burst GO:0060263 8 5 1,000 5,744E-04 0,01348121 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 5,744E-04 0,01334504 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 5,744E-04 0,01321159 ! interphase GO:0051325 159 88 4,000 5,779E-04 0,01316111 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 6,095E-04 0,0137438 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 6,095E-04 0,01361037 ! regulation of behavior GO:0050795 38 22 2,000 6,095E-04 0,0134795 ! protein tetramerization GO:0051262 39 22 2,000 6,095E-04 0,01335112 ! aging GO:0007568 79 52 3,000 6,719E-04 0,01457919 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 6,97E-04 0,01498266 ! negative regulation of DNA replication GO:0008156 35 23 2,000 6,97E-04 0,01484393 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 6,97E-04 0,01470774 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 7,437E-04 0,01554993 ! carbohydrate catabolic process GO:0016052 121 93 4,000 7,437E-04 0,01540984 ! glucose catabolic process GO:0006007 66 54 3,000 7,757E-04 0,01592921 ! mitochondrial membrane organization GO:0007006 39 24 2,000 7,921E-04 0,01612332 ! regulation of helicase activity GO:0051095 11 6 1,000 8,573E-04 0,01729631 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 8,573E-04 0,01714591 ! male meiosis GO:0007140 7 6 1,000 8,573E-04 0,0169981 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 8,573E-04 0,01685282 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 8,573E-04 0,01670999 ! male sex determination GO:0030238 9 6 1,000 8,573E-04 0,01656957 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 8,573E-04 0,01643149 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! activation of MAPKKK activity GO:0000185 10 6 1,000 8,573E-04 0,0162957 ! pigment granule organization GO:0048753 11 6 1,000 8,573E-04 0,01616213 ! ER overload response GO:0006983 7 6 1,000 8,573E-04 0,01603073 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 8,573E-04 0,01590145 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 8,573E-04 0,01577424 ! midbrain development GO:0030901 6 6 1,000 8,573E-04 0,01564904 ! blastocyst growth GO:0001832 15 6 1,000 8,573E-04 0,01552582 ! response to light stimulus GO:0009416 153 96 4,000 8,588E-04 0,01543197 ! male gonad development GO:0008584 33 25 2,000 8,951E-04 0,01595989 ! gonad development GO:0008406 79 57 3,000 9,519E-04 0,01684043 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 9,867E-04 0,01732446 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,006E-03 0,0175332 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 1,006E-03 0,01740138 ! actin filament organization GO:0007015 95 59 3,000 1,084E-03 0,01860332 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,126E-03 0,01917896 ! behavioral fear response GO:0001662 13 7 1,000 1,194E-03 0,02019579 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,194E-03 0,02004837 ! protein heterooligomerization GO:0051291 10 7 1,000 1,194E-03 0,01990309 ! response to tumor cell GO:0002347 12 7 1,000 1,194E-03 0,0197599 ! glycerol-3-phosphate metabolic process GO:0006072 9 7 1,000 1,194E-03 0,01961876 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,194E-03 0,01947962 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,194E-03 0,01934244 ! organ growth GO:0035265 11 7 1,000 1,194E-03 0,01920718 ! response to UV-B GO:0010224 11 7 1,000 1,194E-03 0,0190738 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,194E-03 0,01894225 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,194E-03 0,01881251 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,194E-03 0,01868454 ! meiosis GO:0007126 96 61 3,000 1,228E-03 0,01908663 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 3,000 1,228E-03 0,01895853 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 3,000 1,228E-03 0,01883214 ! cell junction assembly GO:0034329 56 28 2,000 1,254E-03 0,01909729 ! response to organic cyclic substance GO:0014070 47 28 2,000 1,254E-03 0,01897165 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,254E-03 0,01884765 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,254E-03 0,01872526 ! cellular hormone metabolic process GO:0034754 87 62 3,000 1,305E-03 0,01936701 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 3,000 1,305E-03 0,01924286 ! meiotic cell cycle GO:0051321 97 62 3,000 1,305E-03 0,01912029 ! tissue homeostasis GO:0001894 42 29 2,000 1,391E-03 0,02024365 GO:0048871|multicellular organismal homeostasis, ! cell cycle checkpoint GO:0000075 108 64 3,000 1,469E-03 0,02125178 ! hexose catabolic process GO:0019320 82 64 3,000 1,469E-03 0,02111895 ! regulation of microtubule-based process GO:0032886 58 30 2,000 1,537E-03 0,02195083 ! reproductive structure development GO:0048608 90 65 3,000 1,556E-03 0,02209542 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 3,000 1,556E-03 0,02195986 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 3,000 1,556E-03 0,02182596 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,584E-03 0,02208356 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,584E-03 0,02195052 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,584E-03 0,02181908 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,584E-03 0,02168921 ! melanin metabolic process GO:0006582 12 8 1,000 1,584E-03 0,02156087 ! multicellular organism growth GO:0035264 14 8 1,000 1,584E-03 0,02143404 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,584E-03 0,0213087 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,584E-03 0,02118481 ! regulation of embryonic development GO:0045995 16 8 1,000 1,584E-03 0,02106235 ! cell-substrate adhesion GO:0031589 121 66 3,000 1,647E-03 0,02177018 ! mammary gland development GO:0030879 57 31 2,000 1,692E-03 0,02223396 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 1,692E-03 0,02210763 ! metanephros development GO:0001656 58 31 2,000 1,692E-03 0,02198273 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,692E-03 0,02185923 GO:0060326|cell chemotaxis, ! development of primary sexual characteristics GO:0045137 92 68 3,000 1,839E-03 0,02363236 ! regulation of muscle development GO:0048634 48 32 2,000 1,856E-03 0,02371972 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 1,856E-03 0,02358867 ! meiosis I GO:0007127 52 32 2,000 1,856E-03 0,02345907 ! regulation of protein stability GO:0031647 48 32 2,000 1,856E-03 0,02333087 ! response to drug GO:0042493 108 69 3,000 1,941E-03 0,02426173 ! positive regulation of ligase activity GO:0051351 99 69 3,000 1,941E-03 0,02413058 ! regulation of developmental growth GO:0048638 13 9 1,000 2,027E-03 0,02506112 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,027E-03 0,0249271 ! regulation of glycolysis GO:0006110 15 9 1,000 2,027E-03 0,02479451 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 2,027E-03 0,02466332 ! T cell selection GO:0045058 18 9 1,000 2,027E-03 0,02453351 ! receptor clustering GO:0043113 15 9 1,000 2,027E-03 0,02440507 ! motor axon guidance GO:0008045 14 9 1,000 2,027E-03 0,02427796 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 2,027E-03 0,02415216 ! thymus development GO:0048538 15 9 1,000 2,027E-03 0,02402767 ! response to nicotine GO:0035094 16 9 1,000 2,027E-03 0,02390445 ! cell junction organization GO:0034330 63 33 2,000 2,031E-03 0,02382839 ! female gonad development GO:0008585 49 33 2,000 2,031E-03 0,02370744 ! cytokinesis GO:0000910 52 33 2,000 2,031E-03 0,0235877 ! regulation of catabolic process GO:0009894 106 70 3,000 2,046E-03 0,02365292 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 2,156E-03 0,02479341 ! steroid biosynthetic process GO:0006694 94 71 3,000 2,156E-03 0,02467006 ! lymphocyte differentiation GO:0030098 113 71 3,000 2,156E-03 0,02454793 ! monosaccharide catabolic process GO:0046365 91 71 3,000 2,156E-03 0,024427 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 2,215E-03 0,02496979 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 2,215E-03 0,02484798 ! female gamete generation GO:0007292 43 34 2,000 2,215E-03 0,02472736 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 2,215E-03 0,02460791 ! response to steroid hormone stimulus GO:0048545 114 73 3,000 2,387E-03 0,02639318 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 2,409E-03 0,02650907 ! protein import into nucleus GO:0006606 118 74 3,000 2,508E-03 0,02747363 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 2,508E-03 0,02734343 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,521E-03 0,02734669 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,521E-03 0,0272183 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 2,521E-03 0,02709111 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,521E-03 0,0269651 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,521E-03 0,02684027 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,521E-03 0,02671658 ! B cell proliferation GO:0042100 14 10 1,000 2,521E-03 0,02659402 ! fear response GO:0042596 16 10 1,000 2,521E-03 0,02647259 ! negative regulation of ossification GO:0030279 19 10 1,000 2,521E-03 0,02635226 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,521E-03 0,02623302 ! cranial nerve development GO:0021545 12 10 1,000 2,521E-03 0,02611485 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,521E-03 0,02599775 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,521E-03 0,02588168 ! neural tube development GO:0021915 50 36 2,000 2,613E-03 0,02671317 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 2,613E-03 0,02659497 GO:0046660|female sex differentiation, ! regulation of ligase activity GO:0051340 114 75 3,000 2,634E-03 0,02669068 ! nuclear import GO:0051170 121 75 3,000 2,634E-03 0,02657362 ! gland development GO:0048732 148 77 3,000 2,899E-03 0,02911355 ! sex differentiation GO:0007548 105 77 3,000 2,899E-03 0,02898697 ! pigmentation GO:0043473 74 38 2,000 3,053E-03 0,03040144 ! virus-host interaction GO:0019048 17 11 1,000 3,065E-03 0,03038934 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 3,065E-03 0,03025891 GO:0000725|recombinational repair, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 3,065E-03 0,0301296 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,065E-03 0,03000139 ! cellular carbohydrate catabolic process GO:0044275 13 11 1,000 3,065E-03 0,02987427 ! regulation of intracellular pH GO:0051453 17 11 1,000 3,065E-03 0,02974821 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 3,065E-03 0,02962322 ! T cell homeostasis GO:0043029 20 11 1,000 3,065E-03 0,02949928 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,065E-03 0,02937636 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 3,065E-03 0,02925447 GO:0042130|negative regulation of T cell proliferation, ! T cell activation GO:0042110 134 79 3,000 3,181E-03 0,03023031 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,289E-03 0,03113459 ! male sex differentiation GO:0046661 53 39 2,000 3,289E-03 0,03100699 ! developmental growth GO:0048589 62 39 2,000 3,289E-03 0,03088043 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 3,000 3,329E-03 0,03112071 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 3,000 3,329E-03 0,03099472 ! double-strand break repair GO:0006302 67 40 2,000 3,536E-03 0,0327973 ! B cell differentiation GO:0030183 62 40 2,000 3,536E-03 0,03266559 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 3,66E-03 0,03367211 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 3,66E-03 0,03353796 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,66E-03 0,03340487 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! autonomic nervous system development GO:0048483 23 12 1,000 3,66E-03 0,03327283 ! gland morphogenesis GO:0022612 23 12 1,000 3,66E-03 0,03314184 ! regulation of defense response GO:0031347 117 84 3,000 3,967E-03 0,0357771 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 3,967E-03 0,03563735 ! mitochondrial transport GO:0006839 60 42 2,000 4,064E-03 0,03636707 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 4,064E-03 0,03622612 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 4,138E-03 0,03674791 ! anterior/posterior pattern formation GO:0009952 124 85 3,000 4,138E-03 0,03660658 ! regulation of protein localization GO:0032880 132 85 3,000 4,138E-03 0,03646632 ! NAD metabolic process GO:0019674 21 13 1,000 4,304E-03 0,03778164 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 4,304E-03 0,03763799 ! intermediate filament cytoskeleton organization GO:0045104 23 13 1,000 4,304E-03 0,03749542 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,304E-03 0,03735392 ! regulation of cellular pH GO:0030641 20 13 1,000 4,304E-03 0,0372135 ! cellular pigmentation GO:0033059 24 13 1,000 4,304E-03 0,03707412 ! lymphocyte homeostasis GO:0002260 24 13 1,000 4,304E-03 0,03693578 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 4,344E-03 0,03714346 ! leukocyte migration GO:0050900 60 43 2,000 4,344E-03 0,03700589 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 4,344E-03 0,03686933 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,636E-03 0,03920306 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 4,636E-03 0,03905946 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 4,636E-03 0,03891691 ! positive regulation of cell cycle GO:0045787 77 45 2,000 4,94E-03 0,04131482 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 4,94E-03 0,04116513 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 4,996E-03 0,04148314 ! regulation of S phase GO:0033261 18 14 1,000 4,996E-03 0,04133392 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,996E-03 0,04118577 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,996E-03 0,04103867 ! activation of MAPKK activity GO:0000186 21 14 1,000 4,996E-03 0,04089263 ! epidermis morphogenesis GO:0048730 29 14 1,000 4,996E-03 0,04074762 ! cellular response to starvation GO:0009267 21 14 1,000 4,996E-03 0,04060363 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,996E-03 0,04046066 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,996E-03 0,0403187 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 4,996E-03 0,04017772 ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,996E-03 0,04003773 ! intermediate filament-based process GO:0045103 24 14 1,000 4,996E-03 0,03989871 ! axon cargo transport GO:0008088 27 14 1,000 4,996E-03 0,03976065 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,996E-03 0,03962355 ! regulation of ATPase activity GO:0043462 18 14 1,000 4,996E-03 0,03948738 ! leukocyte differentiation GO:0002521 143 90 3,000 5,071E-03 0,03994561 ! hormone metabolic process GO:0042445 121 90 3,000 5,071E-03 0,03980928 ! histone modification GO:0016570 68 46 2,000 5,255E-03 0,04111193 ! response to estrogen stimulus GO:0043627 74 47 2,000 5,582E-03 0,04352376 ! covalent chromatin modification GO:0016569 75 47 2,000 5,582E-03 0,04337672 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 5,582E-03 0,04323067 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 5,582E-03 0,0430856 ! metencephalon development GO:0022037 19 15 1,000 5,736E-03 0,04412166 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,736E-03 0,04397459 ! lipid phosphorylation GO:0046834 23 15 1,000 5,736E-03 0,04382849 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,736E-03 0,04368336 ! centrosome cycle GO:0007098 16 15 1,000 5,736E-03 0,04353919 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 5,736E-03 0,04339597 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,736E-03 0,04325369 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 5,736E-03 0,04311234 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,736E-03 0,04297191 ! defense response to virus GO:0051607 27 15 1,000 5,736E-03 0,04283239 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 5,736E-03 0,04269377 ! regulation of muscle contraction GO:0006937 69 48 2,000 5,922E-03 0,04393438 ! regulation of binding GO:0051098 151 95 3,000 6,136E-03 0,04538056 ! regulation of intracellular transport GO:0032386 78 49 2,000 6,273E-03 0,04624233 ! cartilage development GO:0051216 70 49 2,000 6,273E-03 0,04609459 ! regulation of response to external stimulus GO:0032101 139 96 3,000 6,366E-03 0,04662769 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 6,522E-03 0,0476244 ! regulation of protein binding GO:0043393 27 16 1,000 6,522E-03 0,04747369 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 6,522E-03 0,04732393 ! nerve development GO:0021675 18 16 1,000 6,522E-03 0,04717511 ! negative regulation of translation GO:0017148 22 16 1,000 6,522E-03 0,04702722 ! positive regulation of growth GO:0045927 67 50 2,000 6,636E-03 0,04769877 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 7,012E-03 0,05024267 ! positive regulation of cell migration GO:0030335 92 51 2,000 7,012E-03 0,05008664 ! regulation of protein catabolic process GO:0042176 77 51 2,000 7,012E-03 0,04993157 ! negative regulation of cell motion GO:0051271 104 51 2,000 7,012E-03 0,04977746 ! protein import GO:0017038 156 99 3,000 7,088E-03 0,05016171 ! protein localization in organelle GO:0033365 161 100 3,000 7,34E-03 0,05178802 ! glycerol metabolic process GO:0006071 20 17 1,000 7,355E-03 0,05173403 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 7,355E-03 0,05157631 ! regulation of viral genome replication GO:0045069 24 17 1,000 7,355E-03 0,05141954 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 7,355E-03 0,05126372 ! actin filament bundle formation GO:0051017 26 17 1,000 7,355E-03 0,05110885 ! neuromuscular junction development GO:0007528 23 17 1,000 7,355E-03 0,05095491 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,355E-03 0,05080189 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 7,355E-03 0,05064979 ! peptidyl-serine modification GO:0018209 27 17 1,000 7,355E-03 0,05049859 ! proximal/distal pattern formation GO:0009954 25 17 1,000 7,355E-03 0,0503483 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 7,355E-03 0,0501989 ! nucleotide-excision repair GO:0006289 64 52 2,000 7,4E-03 0,05035711 ! kidney development GO:0001822 90 53 2,000 7,801E-03 0,05292697 ! positive regulation of DNA replication GO:0045740 29 18 1,000 8,233E-03 0,05569618 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 8,233E-03 0,05553285 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 8,233E-03 0,05537047 ! somitogenesis GO:0001756 24 18 1,000 8,233E-03 0,05520904 ! cellular response to nutrient levels GO:0031669 27 18 1,000 8,233E-03 0,05504855 ! gut development GO:0048565 26 18 1,000 8,233E-03 0,05488899 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 8,233E-03 0,05473035 ! negative regulation of T cell activation GO:0050868 25 18 1,000 8,233E-03 0,05457262 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 8,233E-03 0,05441581 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 9,079E-03 0,05983176 ! positive regulation of cell motion GO:0051272 99 56 2,000 9,079E-03 0,05966082 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 9,156E-03 0,05999719 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 9,156E-03 0,05982674 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 9,156E-03 0,05965726 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 9,156E-03 0,05948874 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 9,156E-03 0,05932117 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 9,156E-03 0,05915453 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 9,156E-03 0,05898883 ! response to alkaloid GO:0043279 32 19 1,000 9,156E-03 0,05882406 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 9,156E-03 0,05866021 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 9,156E-03 0,05849726 ! response to starvation GO:0042594 30 19 1,000 9,156E-03 0,05833522 ! renal system process GO:0003014 35 19 1,000 9,156E-03 0,05817407 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 9,156E-03 0,05801381 ! protein stabilization GO:0050821 26 19 1,000 9,156E-03 0,05785443 ! secondary metabolic process GO:0019748 84 57 2,000 9,53E-03 0,06005406 ! microtubule-based transport GO:0010970 37 20 1,000 0,01012274 0,06361284 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01012274 0,06343951 ! response to ethanol GO:0045471 37 20 1,000 0,01012274 0,06326712 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01012274 0,06309566 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01012274 0,06292513 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01012274 0,06275552 ! collagen catabolic process GO:0030574 25 20 1,000 0,01012274 0,06258683 ! alditol metabolic process GO:0019400 24 20 1,000 0,01012274 0,06241903 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,01096249 0,06741637 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 2,000 0,01096249 0,06723659 ! regulation of heart contraction GO:0008016 91 60 2,000 0,01096249 0,06705777 ! ovarian follicle development GO:0001541 30 21 1,000 0,01113257 0,06791753 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01113257 0,06773786 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01113257 0,06755913 ! gluconeogenesis GO:0006094 25 21 1,000 0,01113257 0,06738134 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01113257 0,06720449 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01113257 0,06702856 ! acetyl-CoA catabolic process GO:0046356 31 21 1,000 0,01113257 0,06685355 GO:0006099|tricarboxylic acid cycle, ! urogenital system development GO:0001655 101 61 2,000 0,01146599 0,06867648 ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01146599 0,0684981 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01218488 0,07260418 ! molting cycle process GO:0022404 40 22 1,000 0,01218488 0,07241657 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01218488 0,07222993 ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01218488 0,07204425 ! vasculogenesis GO:0001570 33 22 1,000 0,01218488 0,07185952 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01218488 0,07167574 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01218488 0,07149289 GO:0010810|regulation of cell-substrate adhesion, ! ureteric bud development GO:0001657 32 22 1,000 0,01218488 0,07131098 ! coenzyme catabolic process GO:0009109 33 22 1,000 0,01218488 0,07112998 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01218488 0,07094991 ! blastocyst development GO:0001824 37 22 1,000 0,01218488 0,07077074 ! neural tube closure GO:0001843 33 22 1,000 0,01218488 0,07059248 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,0125125 0,0723084 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,0125125 0,07212717 ! appendage morphogenesis GO:0035107 93 64 2,000 0,01305561 0,07506977 GO:0035108|limb morphogenesis, ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 0,01305561 0,07488256 ! acetyl-CoA metabolic process GO:0006084 33 23 1,000 0,01327896 0,07597413 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01327896 0,07578561 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01327896 0,07559802 ! interaction with host GO:0051701 37 23 1,000 0,01327896 0,07541136 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01327896 0,07522562 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01327896 0,07504079 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01327896 0,07485686 ! myelination GO:0042552 35 23 1,000 0,01327896 0,07467384 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01327896 0,07449171 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01327896 0,07431046 ! appendage development GO:0048736 94 65 2,000 0,01361203 0,0759895 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 2,000 0,01361203 0,0758055 ! protein oligomerization GO:0051259 100 65 2,000 0,01361203 0,0756224 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,01441412 0,07988549 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,01441412 0,07969346 ! receptor metabolic process GO:0043112 37 24 1,000 0,01441412 0,07950235 ! response to toxin GO:0009636 38 24 1,000 0,01441412 0,07931215 ! primary neural tube formation GO:0014020 35 24 1,000 0,01441412 0,07912286 ! negative regulation of cell development GO:0010721 56 24 1,000 0,01441412 0,07893448 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,01441412 0,07874698 ! learning or memory GO:0007611 123 68 2,000 0,01536152 0,08372392 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01558968 0,08476661 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01558968 0,08456669 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01558968 0,08436771 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01558968 0,08416966 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01558968 0,08397254 ! eye development GO:0001654 111 70 2,000 0,01659506 0,08917904 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 0,01659506 0,08897116 ! regulation of pH GO:0006885 36 26 1,000 0,01680497 0,08988705 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01680497 0,0896785 ! post-embryonic development GO:0009791 42 26 1,000 0,01680497 0,08947091 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 0,01680497 0,08926428 ! nicotinamide metabolic process GO:0006769 39 26 1,000 0,01680497 0,0890586 GO:0046496|nicotinamide nucleotide metabolic process, ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01723208 0,09111212 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 0,01788263 0,09433496 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 2,000 0,01788263 0,09411909 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01788263 0,09390421 ! alkaloid metabolic process GO:0009820 40 27 1,000 0,01805931 0,09461598 ! cofactor catabolic process GO:0051187 45 27 1,000 0,01805931 0,09440094 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01805931 0,09418688 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01805931 0,09397379 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01805931 0,09376166 ! tube morphogenesis GO:0035239 118 73 2,000 0,01854673 0,09607541 ! mitochondrion organization GO:0007005 104 73 2,000 0,01854673 0,09585951 ! response to oxygen levels GO:0070482 137 74 2,000 0,01922441 0,09913931 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,01935204 0,09957428 GO:0055092|sterol homeostasis, ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01935204 0,09935201 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01935204 0,09913074 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 1,000 0,01935204 0,09891045 ! neural tube formation GO:0001841 41 28 1,000 0,01935204 0,09869113 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01935204 0,09847279 ! response to nutrient GO:0007584 104 75 2,000 0,01991566 0,10111704 ! regulation of protein transport GO:0051223 114 76 2,000 0,02062051 0,10446515 GO:0070201|regulation of establishment of protein localization, ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02068252 0,10454899 ! ovulation cycle process GO:0022602 41 29 1,000 0,02068252 0,10431972 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,02068252 0,10409145 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,02068252 0,10386417 ! regulation of DNA binding GO:0051101 119 77 2,000 0,02133896 0,10692727 ! spindle organization GO:0007051 37 30 1,000 0,02205009 0,11025043 ! collagen metabolic process GO:0032963 40 30 1,000 0,02205009 0,11001128 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,02205009 0,10977316 ! ovulation cycle GO:0042698 43 30 1,000 0,02205009 0,10953607 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02205009 0,1093 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,02205009 0,10906494 ! response to heat GO:0009408 41 30 1,000 0,02205009 0,1088309 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,02207102 0,10870097 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,02345411 0,11526593 ! segmentation GO:0035282 41 31 1,000 0,02345411 0,11502017 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02345411 0,11477544 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02434885 0,11890098 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02489396 0,12130533 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,02489396 0,12104888 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02489396 0,1207935 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02489396 0,1205392 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02489396 0,12028596 ! cytokine production GO:0001816 44 32 1,000 0,02489396 0,12003379 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,02489396 0,11978267 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02489396 0,11953261 ! ossification GO:0001503 134 82 2,000 0,02513534 0,12044016 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 2,000 0,02593542 0,1240155 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02636902 0,12582728 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02636902 0,12556676 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02636902 0,12530733 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02636902 0,12504896 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02636902 0,12479166 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02636902 0,12453542 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02636902 0,12428022 ! lipid homeostasis GO:0055088 55 33 1,000 0,02636902 0,12402607 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02636902 0,12377295 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,02636902 0,12352087 ! rRNA metabolic process GO:0016072 107 85 2,000 0,0275763 0,12891362 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,0275763 0,12865213 ! regulation of membrane potential GO:0042391 128 85 2,000 0,0275763 0,1283917 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02787866 0,12953723 ! neuron migration GO:0001764 46 34 1,000 0,02787866 0,12927607 ! polyol metabolic process GO:0019751 44 34 1,000 0,02787866 0,12901595 ! aerobic respiration GO:0009060 47 34 1,000 0,02787866 0,12875689 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02927141 0,13491832 GO:0060538|skeletal muscle organ development, ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02942229 0,13534253 ! maintenance of protein location GO:0045185 65 35 1,000 0,02942229 0,13507238 ! pigment metabolic process GO:0042440 61 35 1,000 0,02942229 0,13480332 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02942229 0,13453532 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,03013925 0,13754021 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03099929 0,14118489 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,03099929 0,14090587 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,03099929 0,14062795 ! negative regulation of binding GO:0051100 58 36 1,000 0,03099929 0,14035112 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,03102058 0,14017156 ! learning GO:0007612 67 37 1,000 0,03260908 0,14706055 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 1,000 0,03260908 0,14677276 ! cell fate commitment GO:0045165 141 92 2,000 0,03374528 0,15159012 ! DNA recombination GO:0006310 146 92 2,000 0,03374528 0,15129463 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,03425106 0,15326351 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,03425106 0,15296591 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03425106 0,15266947 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,03425106 0,15237417 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,03468032 0,15398599 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,03592466 0,15920371 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,03592466 0,15889755 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03592466 0,15859257 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03592466 0,15828875 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,03592466 0,15798609 ! synapse organization GO:0050808 55 39 1,000 0,03592466 0,15768459 ! in utero embryonic development GO:0001701 147 96 2,000 0,03756542 0,16457231 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03762931 0,1645388 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03762931 0,16422659 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03774635 0,16442537 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03774635 0,16411455 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03774635 0,1638049 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03774635 0,16349642 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03774635 0,16318909 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03774635 0,16288292 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03774635 0,1625779 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03774635 0,16227401 ! sleep GO:0030431 11 5 0,000 0,03774635 0,16197126 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03774635 0,16166964 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03774635 0,16136914 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03774635 0,16106975 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03774635 0,16077148 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03774635 0,1604743 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03774635 0,16017822 ! tongue development GO:0043586 6 5 0,000 0,03774635 0,15988324 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03774635 0,15958933 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03774635 0,15929651 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03774635 0,15900476 ! cobalt ion transport GO:0006824 9 5 0,000 0,03774635 0,15871407 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03774635 0,15842445 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03774635 0,15813588 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03774635 0,15784836 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03774635 0,15756188 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03774635 0,15727644 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03774635 0,15699204 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03774635 0,15670866 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03774635 0,1564263 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03774635 0,15614496 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03774635 0,15586463 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03774635 0,1555853 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03774635 0,15530697 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03774635 0,15502964 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03774635 0,15475329 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03774635 0,15447793 ! behavioral response to pain GO:0048266 7 5 0,000 0,03774635 0,15420355 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03774635 0,15393014 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03774635 0,15365769 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03774635 0,15338621 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03774635 0,15311569 ! mating behavior GO:0007617 6 5 0,000 0,03774635 0,15284612 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03774635 0,1525775 ! rhythmic behavior GO:0007622 12 5 0,000 0,03774635 0,15230982 ! copulation GO:0007620 7 5 0,000 0,03774635 0,15204308 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03774635 0,15177727 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03774635 0,15151239 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03774635 0,15124843 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03774635 0,15098539 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03774635 0,15072326 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03774635 0,15046204 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03774635 0,15020173 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03774635 0,14994231 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03774635 0,14968379 ! response to protozoan GO:0001562 9 5 0,000 0,03774635 0,14942616 ! lymph vessel development GO:0001945 7 5 0,000 0,03774635 0,14916941 ! endochondral ossification GO:0001958 12 5 0,000 0,03774635 0,14891355 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03774635 0,14865856 ! parathyroid gland development GO:0060017 8 5 0,000 0,03774635 0,14840444 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03774635 0,14815119 ! anagen GO:0042640 6 5 0,000 0,03774635 0,1478988 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03774635 0,14764727 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03774635 0,1473966 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03774635 0,14714677 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03774635 0,1468978 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03774635 0,14664966 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03774635 0,14640236 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03774635 0,14615589 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03774635 0,14591025 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03774635 0,14566543 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03774635 0,14542144 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03774635 0,14517826 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03774635 0,14493589 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03774635 0,14469433 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03774635 0,14445357 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03774635 0,14421362 ! ovulation GO:0030728 6 5 0,000 0,03774635 0,14397446 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03774635 0,14373609 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03774635 0,14349851 ! response to pH GO:0009268 9 5 0,000 0,03774635 0,14326171 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03774635 0,1430257 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03774635 0,14279046 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03774635 0,14255599 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03774635 0,14232229 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03774635 0,14208936 ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03774635 0,14185718 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03774635 0,14162577 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03774635 0,14139511 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03774635 0,1411652 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03774635 0,14093603 ! urea metabolic process GO:0019627 6 5 0,000 0,03774635 0,14070761 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03774635 0,14047993 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03774635 0,14025298 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03774635 0,14002677 ! neutrophil activation GO:0042119 5 5 0,000 0,03774635 0,13980128 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03774635 0,13957652 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03774635 0,13935248 ! response to food GO:0032094 5 5 0,000 0,03774635 0,13912916 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03774635 0,13890656 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03774635 0,13868466 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03774635 0,13846347 ! forebrain neuron development GO:0021884 7 5 0,000 0,03774635 0,13824299 ! melanosome organization GO:0032438 7 5 0,000 0,03774635 0,13802321 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03774635 0,13780412 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03774635 0,13758573 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03774635 0,13736803 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03774635 0,13715102 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03774635 0,1369347 ! nucleoside transport GO:0015858 6 5 0,000 0,03774635 0,13671905 ! nucleoside salvage GO:0043174 7 5 0,000 0,03774635 0,13650408 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03774635 0,13628979 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03774635 0,13607617 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03774635 0,13586322 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03774635 0,13565093 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03774635 0,13543931 ! depyrimidination GO:0045008 8 5 0,000 0,03774635 0,13522834 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03774635 0,13501804 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03774635 0,13480838 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03774635 0,13459938 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03774635 0,13439102 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03774635 0,1341833 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03774635 0,13397623 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03774635 0,1337698 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03774635 0,133564 ! monocyte differentiation GO:0030224 8 5 0,000 0,03774635 0,13335883 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03774635 0,13315429 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03774635 0,13295038 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03774635 0,13274709 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03774635 0,13254442 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03774635 0,13234237 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03774635 0,13214094 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03774635 0,13194012 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03774635 0,1317399 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03774635 0,1315403 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03774635 0,1313413 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03774635 0,1311429 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03774635 0,13094509 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03774635 0,13074789 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03774635 0,13055127 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03774635 0,13035525 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03774635 0,13015982 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03774635 0,12996497 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03774635 0,1297707 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03774635 0,12957701 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03774635 0,1293839 ! histone demethylation GO:0016577 9 5 0,000 0,03774635 0,12919136 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03774635 0,1289994 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03774635 0,12880801 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03774635 0,12861718 ! enteric nervous system development GO:0048484 8 5 0,000 0,03774635 0,12842692 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03774635 0,12823722 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03774635 0,12804808 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03774635 0,1278595 ! transcription termination GO:0006353 8 5 0,000 0,03774635 0,12767147 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03774635 0,12748399 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03774635 0,12729706 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03774635 0,12711068 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03774635 0,12692485 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03774635 0,12673956 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03774635 0,12655481 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03774635 0,12637059 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03774635 0,12618691 ! apical protein localization GO:0045176 6 5 0,000 0,03774635 0,12600377 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03774635 0,12582116 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03774635 0,12563907 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03774635 0,12545751 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03774635 0,12527647 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03774635 0,12509596 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03774635 0,12491597 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03774635 0,12473649 ! glial cell migration GO:0008347 10 5 0,000 0,03774635 0,12455753 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03774635 0,12437908 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03774635 0,12420114 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03774635 0,12402371 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03774635 0,12384679 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03774635 0,12367037 ! neural plate development GO:0001840 6 5 0,000 0,03774635 0,12349445 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03774635 0,12331903 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03774635 0,12314411 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03774635 0,12296968 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03774635 0,12279575 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03774635 0,12262231 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03774635 0,12244936 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03774635 0,1222769 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03774635 0,12210492 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03774635 0,12193342 ! spindle assembly GO:0051225 5 5 0,000 0,03774635 0,12176241 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03774635 0,12159187 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03774635 0,12142181 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03774635 0,12125223 ! organ regeneration GO:0031100 7 5 0,000 0,03774635 0,12108312 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03774635 0,12091448 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03774635 0,12074631 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03774635 0,12057861 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03774635 0,12041137 GO:0055081|anion homeostasis, ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03936443 0,12539916 ! glucose transport GO:0015758 52 41 1,000 0,03936443 0,12522572 ! endosome transport GO:0016197 71 41 1,000 0,03936443 0,12505275 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03936443 0,12488027 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,03936443 0,12470826 ! extracellular structure organization GO:0043062 156 99 2,000 0,04056968 0,12834975 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,04112947 0,12994201 ! hexose transport GO:0008645 54 42 1,000 0,04112947 0,12976377 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,04112947 0,12958601 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,04112947 0,12940874 ! positive regulation of binding GO:0051099 59 43 1,000 0,04292388 0,13487011 ! activation of caspase activity GO:0006919 65 43 1,000 0,04292388 0,13468611 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04292388 0,13450261 ! vesicle organization GO:0016050 79 43 1,000 0,04292388 0,13431962 ! regulation of action potential GO:0001508 71 44 1,000 0,0447471 0,13983469 ! tRNA transcription GO:0009304 11 6 0,000 0,04512416 0,14082166 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04512416 0,14063084 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04512416 0,14044054 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04512416 0,14025076 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04512416 0,14006149 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04512416 0,13987272 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04512416 0,13968447 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04512416 0,13949672 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04512416 0,13930948 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04512416 0,13912274 ! prostate gland development GO:0030850 9 6 0,000 0,04512416 0,13893649 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04512416 0,13875075 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04512416 0,1385655 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04512416 0,13838075 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04512416 0,13819649 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04512416 0,13801271 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04512416 0,13782943 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04512416 0,13764663 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04512416 0,13746432 ! neuron adhesion GO:0007158 9 6 0,000 0,04512416 0,13728249 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04512416 0,13710114 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04512416 0,13692026 ! signal peptide processing GO:0006465 8 6 0,000 0,04512416 0,13673987 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04512416 0,13655995 ! mRNA stabilization GO:0048255 15 6 0,000 0,04512416 0,1363805 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04512416 0,13620152 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04512416 0,13602302 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04512416 0,13584497 ! opsonization GO:0008228 8 6 0,000 0,04512416 0,1356674 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04512416 0,13549029 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04512416 0,13531364 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04512416 0,13513745 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04512416 0,13496172 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04512416 0,13478644 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04512416 0,13461162 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04512416 0,13443725 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04512416 0,13426334 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04512416 0,13408987 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04512416 0,13391685 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04512416 0,13374428 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04512416 0,13357215 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04512416 0,13340046 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04512416 0,13322922 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04512416 0,13305841 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04512416 0,13288804 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04512416 0,13271811 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04512416 0,13254861 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04512416 0,13237954 ! thymic T cell selection GO:0045061 12 6 0,000 0,04512416 0,13221091 ! protein lipoylation GO:0009249 10 6 0,000 0,04512416 0,1320427 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04512416 0,13187492 ! drug transport GO:0015893 6 6 0,000 0,04512416 0,13170756 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04512416 0,13154063 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04512416 0,13137413 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04512416 0,13120804 ! histidine metabolic process GO:0006547 6 6 0,000 0,04512416 0,13104237 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04512416 0,13087713 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04512416 0,13071229 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04512416 0,13054788 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04512416 0,13038387 ! adenohypophysis development GO:0021984 10 6 0,000 0,04512416 0,13022028 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04512416 0,13005709 ! hyperosmotic response GO:0006972 8 6 0,000 0,04512416 0,12989432 ! microtubule nucleation GO:0007020 10 6 0,000 0,04512416 0,12973195 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04512416 0,12956999 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04512416 0,12940843 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04512416 0,12924727 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04512416 0,12908652 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04512416 0,12892616 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04512416 0,1287662 ! response to dietary excess GO:0002021 7 6 0,000 0,04512416 0,12860664 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04512416 0,12844748 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04512416 0,1282887 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04512416 0,12813032 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04512416 0,12797233 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04512416 0,12781473 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04512416 0,12765752 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04512416 0,12750069 ! neuron apoptosis GO:0051402 8 6 0,000 0,04512416 0,12734425 ! organic alcohol transport GO:0015850 9 6 0,000 0,04512416 0,12718819 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04512416 0,12703251 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04512416 0,12687721 ! carnitine transport GO:0015879 8 6 0,000 0,04512416 0,1267223 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04512416 0,12656776 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04512416 0,12641359 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04512416 0,12625981 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04512416 0,12610639 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04512416 0,12595335 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04512416 0,12580068 ! parturition GO:0007567 12 6 0,000 0,04512416 0,12564838 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04512416 0,12549645 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04512416 0,12534488 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04512416 0,12519368 ! spindle checkpoint GO:0031577 14 6 0,000 0,04512416 0,12504284 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04512416 0,12489237 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04512416 0,12474226 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04512416 0,12459251 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04512416 0,12444312 ! macrophage differentiation GO:0030225 10 6 0,000 0,04512416 0,12429408 ! astrocyte development GO:0014002 14 6 0,000 0,04512416 0,12414541 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04512416 0,12399709 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04512416 0,12384912 ! interaction with symbiont GO:0051702 8 6 0,000 0,04512416 0,1237015 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04512416 0,12355424 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04512416 0,12340733 ! eating behavior GO:0042755 6 6 0,000 0,04512416 0,12326076 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04512416 0,12311454 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04512416 0,12296867 ! response to copper ion GO:0046688 9 6 0,000 0,04512416 0,12282315 ! DNA topological change GO:0006265 8 6 0,000 0,04512416 0,12267797 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04512416 0,12253313 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04512416 0,12238863 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04512416 0,12224448 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04512416 0,12210066 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04512416 0,12195718 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04512416 0,12181404 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04512416 0,12167123 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04512416 0,12152876 ! gas homeostasis GO:0033483 11 6 0,000 0,04512416 0,12138662 ! hair follicle maturation GO:0048820 7 6 0,000 0,04512416 0,12124481 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04512416 0,12110334 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04512416 0,12096219 ! Schwann cell development GO:0014044 14 6 0,000 0,04512416 0,12082137 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04512416 0,12068088 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04512416 0,12054072 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04512416 0,12040088 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04512416 0,12026137 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04512416 0,12012218 ! histone ubiquitination GO:0016574 7 6 0,000 0,04512416 0,11998331 ! regulation of meiosis GO:0040020 10 6 0,000 0,04512416 0,11984476 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04512416 0,11970653 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04512416 0,11956862 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04512416 0,11943102 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04512416 0,11929375 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04512416 0,11915679 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04512416 0,11902014 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04512416 0,1188838 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04512416 0,11874778 ! receptor internalization GO:0031623 9 6 0,000 0,04512416 0,11861207 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04512416 0,11847667 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04512416 0,11834157 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04512416 0,11820679 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04512416 0,11807231 ! protein deubiquitination GO:0016579 8 6 0,000 0,04512416 0,11793814 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04512416 0,11780427 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04512416 0,1176707 ! axonal fasciculation GO:0007413 9 6 0,000 0,04512416 0,11753744 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04512416 0,11740448 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04512416 0,11727182 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04512416 0,11713946 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04512416 0,1170074 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04512416 0,11687563 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04512416 0,11674416 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04512416 0,11661299 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04512416 0,11648211 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04512416 0,11635153 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04512416 0,11622123 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04512416 0,11609123 ! adult feeding behavior GO:0008343 6 6 0,000 0,04512416 0,11596152 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04512416 0,1158321 ! pigment granule transport GO:0051904 12 6 0,000 0,04512416 0,11570297 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04512416 0,11557412 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04512416 0,11544556 ! catecholamine transport GO:0051937 7 6 0,000 0,04512416 0,11531729 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04512416 0,1151893 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04512416 0,1150616 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04512416 0,11493418 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04512416 0,11480704 ! protein prenylation GO:0018342 10 6 0,000 0,04512416 0,11468018 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04512416 0,1145536 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04512416 0,1144273 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04512416 0,11430128 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04512416 0,11417553 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04512416 0,11405007 ! cell maturation GO:0048469 60 45 1,000 0,0465986 0,1176474 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04847785 0,12225773 ! regulation of ossification GO:0030278 71 46 1,000 0,04847785 0,12212382 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,05038431 0,12678766 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,05231748 0,13150841 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,05231748 0,13136484 ! heart morphogenesis GO:0003007 65 48 1,000 0,05231748 0,13122158 ! nuclear export GO:0051168 69 48 1,000 0,05231748 0,13107864 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,05231748 0,13093601 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,05244582 0,13111455 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05244582 0,13097219 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05244582 0,13083013 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05244582 0,13068839 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05244582 0,13054695 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05244582 0,13040582 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05244582 0,13026499 GO:0070193|synaptonemal complex organization, ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05244582 0,13012447 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05244582 0,12998425 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05244582 0,12984433 ! reproductive behavior GO:0019098 12 7 0,000 0,05244582 0,12970471 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05244582 0,1295654 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05244582 0,12942638 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05244582 0,12928766 ! oligopeptide transport GO:0006857 11 7 0,000 0,05244582 0,12914923 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05244582 0,1290111 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05244582 0,12887327 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05244582 0,12873573 ! RNA methylation GO:0001510 11 7 0,000 0,05244582 0,12859849 ! pericardium development GO:0060039 8 7 0,000 0,05244582 0,12846154 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05244582 0,12832488 ! fibril organization GO:0043206 13 7 0,000 0,05244582 0,1281885 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05244582 0,12805242 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,05244582 0,12791663 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05244582 0,12778113 ! lipoprotein transport GO:0042953 9 7 0,000 0,05244582 0,12764591 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05244582 0,12751098 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05244582 0,12737633 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05244582 0,12724197 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05244582 0,12710789 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05244582 0,12697409 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05244582 0,12684057 ! chemosensory behavior GO:0007635 9 7 0,000 0,05244582 0,12670734 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05244582 0,12657438 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05244582 0,1264417 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05244582 0,1263093 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05244582 0,12617718 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05244582 0,12604533 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05244582 0,12591376 ! reflex GO:0060004 12 7 0,000 0,05244582 0,12578246 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05244582 0,12565144 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05244582 0,12552069 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05244582 0,12539021 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05244582 0,12526 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05244582 0,12513007 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05244582 0,1250004 ! spinal cord patterning GO:0021511 7 7 0,000 0,05244582 0,124871 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05244582 0,12474186 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05244582 0,124613 ! adrenal gland development GO:0030325 17 7 0,000 0,05244582 0,1244844 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05244582 0,12435606 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05244582 0,12422799 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05244582 0,12410019 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05244582 0,12397264 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05244582 0,12384536 ! endosome organization GO:0007032 10 7 0,000 0,05244582 0,12371834 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05244582 0,12359158 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05244582 0,12346508 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05244582 0,12333884 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05244582 0,12321285 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05244582 0,12308713 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05244582 0,12296165 ! galactose metabolic process GO:0006012 10 7 0,000 0,05244582 0,12283644 ! vesicle fusion GO:0006906 15 7 0,000 0,05244582 0,12271148 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05244582 0,12258677 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05244582 0,12246232 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05244582 0,12233812 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05244582 0,12221417 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05244582 0,12209047 ! retinol metabolic process GO:0042572 9 7 0,000 0,05244582 0,12196702 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05244582 0,12184382 ! rRNA modification GO:0000154 12 7 0,000 0,05244582 0,12172087 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05244582 0,12159817 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05244582 0,12147571 ! intermediate filament organization GO:0045109 11 7 0,000 0,05244582 0,1213535 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05244582 0,12123154 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05244582 0,12110982 ! fibrinolysis GO:0042730 9 7 0,000 0,05244582 0,12098835 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05244582 0,12086712 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05244582 0,12074613 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05244582 0,12062538 ! response to tropane GO:0014073 13 7 0,000 0,05244582 0,12050488 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05244582 0,12038461 ! melanosome localization GO:0032400 10 7 0,000 0,05244582 0,12026459 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05244582 0,1201448 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05244582 0,12002526 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05244582 0,11990595 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05244582 0,11978687 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05244582 0,11966804 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05244582 0,11954944 ! mast cell activation GO:0045576 9 7 0,000 0,05244582 0,11943107 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05244582 0,11931294 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05244582 0,11919504 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05244582 0,11907738 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05244582 0,11895994 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05244582 0,11884274 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05244582 0,11872577 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05244582 0,11860903 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05244582 0,11849252 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05244582 0,11837623 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05244582 0,11826018 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05244582 0,11814435 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05244582 0,11802875 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05244582 0,11791338 ! neuroblast proliferation GO:0007405 13 7 0,000 0,05244582 0,11779823 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05244582 0,1176833 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05244582 0,1175686 ! diuresis GO:0030146 12 7 0,000 0,05244582 0,11745412 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05244582 0,11733987 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05244582 0,11722583 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05244582 0,11711202 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05244582 0,11699843 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05244582 0,11688506 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05244582 0,11677191 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05244582 0,11665898 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05244582 0,11654626 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05244582 0,11643377 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05244582 0,11632149 ! lymph node development GO:0048535 9 7 0,000 0,05244582 0,11620942 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05244582 0,11609758 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05244582 0,11598595 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05244582 0,11587453 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05244582 0,11576332 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05244582 0,11565233 ! ATP catabolic process GO:0006200 10 7 0,000 0,05244582 0,11554155 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05244582 0,11543099 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05244582 0,11532063 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05244582 0,11521049 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05244582 0,11510056 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05244582 0,11499083 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05244582 0,11488132 ! muscle adaptation GO:0043500 12 7 0,000 0,05244582 0,11477201 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05244582 0,11466291 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05244582 0,11455402 ! retina homeostasis GO:0001895 9 7 0,000 0,05244582 0,11444533 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05244582 0,11433686 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05244582 0,11422858 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05244582 0,11412051 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05244582 0,11401265 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05244582 0,11390499 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05244582 0,11379753 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05244582 0,11369028 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,05427682 0,11754867 ! maintenance of location GO:0051235 84 49 1,000 0,05427682 0,11743809 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,05427682 0,11732771 ! ear development GO:0043583 72 50 1,000 0,05626184 0,12150444 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05626184 0,12139046 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,05626184 0,12127669 ! lipid modification GO:0030258 73 50 1,000 0,05626184 0,12116314 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,05626184 0,1210498 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05827203 0,12525764 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,05827203 0,12514068 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,05827203 0,12502395 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05971176 0,12799351 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05971176 0,12787434 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05971176 0,12775539 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05971176 0,12763665 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05971176 0,12751814 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05971176 0,12739985 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05971176 0,12728178 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05971176 0,12716393 ! phosphate transport GO:0006817 10 8 0,000 0,05971176 0,12704629 ! N-glycan processing GO:0006491 12 8 0,000 0,05971176 0,12692887 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05971176 0,12681167 ! UTP metabolic process GO:0046051 8 8 0,000 0,05971176 0,12669469 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05971176 0,12657792 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05971176 0,12646136 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05971176 0,12634502 ! succinate metabolic process GO:0006105 14 8 0,000 0,05971176 0,1262289 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,05971176 0,12611298 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05971176 0,12599728 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05971176 0,1258818 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,05971176 0,12576652 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05971176 0,12565145 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,05971176 0,1255366 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05971176 0,12542195 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05971176 0,12530752 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05971176 0,12519329 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05971176 0,12507927 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05971176 0,12496546 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05971176 0,12485185 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05971176 0,12473846 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05971176 0,12462526 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05971176 0,12451228 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05971176 0,12439949 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05971176 0,12428691 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05971176 0,12417454 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05971176 0,12406237 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05971176 0,1239504 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05971176 0,12383863 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05971176 0,12372706 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05971176 0,1236157 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05971176 0,12350453 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05971176 0,12339357 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,05971176 0,1232828 ! macrophage activation GO:0042116 12 8 0,000 0,05971176 0,12317223 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05971176 0,12306186 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05971176 0,12295169 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05971176 0,12284172 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05971176 0,12273194 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05971176 0,12262236 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05971176 0,12251297 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05971176 0,12240378 ! ruffle organization GO:0031529 11 8 0,000 0,05971176 0,12229478 ! osteoblast development GO:0002076 13 8 0,000 0,05971176 0,12218598 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05971176 0,12207737 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05971176 0,12196895 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05971176 0,12186073 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05971176 0,12175269 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05971176 0,12164485 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05971176 0,1215372 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05971176 0,12142974 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05971176 0,12132247 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05971176 0,12121539 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05971176 0,1211085 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05971176 0,1210018 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05971176 0,12089528 ! segment specification GO:0007379 10 8 0,000 0,05971176 0,12078895 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05971176 0,12068281 ! cellular extravasation GO:0045123 11 8 0,000 0,05971176 0,12057686 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05971176 0,12047109 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05971176 0,1203655 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05971176 0,1202601 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05971176 0,12015489 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05971176 0,12004986 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05971176 0,11994501 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05971176 0,11984035 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05971176 0,11973587 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05971176 0,11963157 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05971176 0,11952745 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05971176 0,11942351 ! icosanoid secretion GO:0032309 12 8 0,000 0,05971176 0,11931976 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05971176 0,11921618 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05971176 0,11911278 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05971176 0,11900957 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05971176 0,11890653 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05971176 0,11880367 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05971176 0,11870098 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05971176 0,11859848 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05971176 0,11849615 ! sterol catabolic process GO:0016127 9 8 0,000 0,05971176 0,118394 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05971176 0,11829202 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05971176 0,11819022 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05971176 0,1180886 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05971176 0,11798715 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05971176 0,11788587 ! prophase GO:0051324 11 8 0,000 0,05971176 0,11778477 ! S phase GO:0051320 8 8 0,000 0,05971176 0,11768384 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05971176 0,11758308 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05971176 0,1174825 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05971176 0,11738209 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05971176 0,11728184 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05971176 0,11718177 ! hormone catabolic process GO:0042447 13 8 0,000 0,05971176 0,11708188 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05971176 0,11698215 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05971176 0,11688259 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05971176 0,1167832 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05971176 0,11668398 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05971176 0,11658492 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,05971176 0,11648604 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05971176 0,11638732 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05971176 0,11628877 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05971176 0,11619039 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05971176 0,11609217 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05971176 0,11599412 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05971176 0,11589624 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05971176 0,11579852 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05971176 0,11570096 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05971176 0,11560357 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,0603069 0,11665759 ! establishment of organelle localization GO:0051656 85 52 1,000 0,0603069 0,11655956 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,06236596 0,12043804 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,06236596 0,120337 ! cell projection assembly GO:0030031 76 53 1,000 0,06236596 0,12023613 ! regulation of mitosis GO:0007088 84 54 1,000 0,06444872 0,12414744 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,06444872 0,12404355 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,06444872 0,12393984 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,06444872 0,1238363 ! water-soluble vitamin metabolic process GO:0006767 71 55 1,000 0,0665547 0,12777613 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06692239 0,12837489 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06692239 0,12826792 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06692239 0,12816111 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06692239 0,12805449 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06692239 0,12794805 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06692239 0,12784178 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06692239 0,12773568 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06692239 0,12762977 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06692239 0,12752403 ! GTP metabolic process GO:0046039 9 9 0,000 0,06692239 0,12741846 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06692239 0,12731307 ! social behavior GO:0035176 14 9 0,000 0,06692239 0,12720785 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06692239 0,12710281 ! artery development GO:0060840 19 9 0,000 0,06692239 0,12699794 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06692239 0,12689324 ! response to pain GO:0048265 16 9 0,000 0,06692239 0,12678871 ! protein complex disassembly GO:0043241 17 9 0,000 0,06692239 0,12668436 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06692239 0,12658018 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06692239 0,12647617 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06692239 0,12637233 ! lung alveolus development GO:0048286 17 9 0,000 0,06692239 0,12626866 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06692239 0,12616516 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06692239 0,12606183 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06692239 0,12595867 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06692239 0,12585568 ! protein targeting to ER GO:0045047 19 9 0,000 0,06692239 0,12575286 ! endoderm development GO:0007492 12 9 0,000 0,06692239 0,1256502 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06692239 0,12554772 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06692239 0,12544539 ! arginine catabolic process GO:0006527 10 9 0,000 0,06692239 0,12534324 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06692239 0,12524125 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06692239 0,12513943 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06692239 0,12503777 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06692239 0,12493628 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06692239 0,12483495 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06692239 0,12473379 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06692239 0,12463279 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06692239 0,12453196 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06692239 0,12443128 ! mannose metabolic process GO:0006013 9 9 0,000 0,06692239 0,12433077 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06692239 0,12423043 ! epithelial cell development GO:0002064 10 9 0,000 0,06692239 0,12413024 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06692239 0,12403022 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06692239 0,12393035 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06692239 0,12383065 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06692239 0,12373111 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06692239 0,12363173 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06692239 0,1235325 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06692239 0,12343344 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06692239 0,12333453 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06692239 0,12323579 ! DNA ligation GO:0006266 14 9 0,000 0,06692239 0,1231372 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06692239 0,12303877 ! response to amine stimulus GO:0014075 13 9 0,000 0,06692239 0,12294049 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06692239 0,12284238 ! erythrocyte development GO:0048821 11 9 0,000 0,06692239 0,12274442 ! renal water homeostasis GO:0003091 14 9 0,000 0,06692239 0,12264661 ! postreplication repair GO:0006301 11 9 0,000 0,06692239 0,12254896 ! mRNA cleavage GO:0006379 13 9 0,000 0,06692239 0,12245147 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06692239 0,12235413 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06692239 0,12225695 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06692239 0,12215992 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06692239 0,12206304 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06692239 0,12196632 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06692239 0,12186975 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06692239 0,12177334 ! acid secretion GO:0046717 14 9 0,000 0,06692239 0,12167707 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06692239 0,12158096 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06692239 0,121485 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06692239 0,12138919 ! purine base metabolic process GO:0006144 18 9 0,000 0,06692239 0,12129354 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06692239 0,12119803 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06692239 0,12110267 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06692239 0,12100747 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06692239 0,12091241 ! detection of calcium ion GO:0005513 13 9 0,000 0,06692239 0,1208175 ! blastocyst formation GO:0001825 12 9 0,000 0,06692239 0,12072274 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06692239 0,12062813 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06692239 0,12053367 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06692239 0,12043936 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06692239 0,12034519 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06692239 0,12025117 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06692239 0,1201573 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06692239 0,12006357 ! prepulse inhibition GO:0060134 14 9 0,000 0,06692239 0,11996999 ! embryonic placenta development GO:0001892 12 9 0,000 0,06692239 0,11987656 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06692239 0,11978327 ! insulin secretion GO:0030073 17 9 0,000 0,06692239 0,11969012 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06692239 0,11959712 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06692239 0,11950427 ! nucleus localization GO:0051647 15 9 0,000 0,06692239 0,11941156 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06692239 0,11931899 ! localization within membrane GO:0051668 15 9 0,000 0,06692239 0,11922657 ! carbohydrate transport GO:0008643 74 57 1,000 0,07083446 0,12609849 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,07083446 0,12600097 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,07083446 0,1259036 ! camera-type eye development GO:0043010 88 57 1,000 0,07083446 0,12580637 ! developmental maturation GO:0021700 75 57 1,000 0,07083446 0,1257093 ! viral reproductive process GO:0022415 87 58 1,000 0,07300731 0,12946554 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,07300731 0,1293658 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07407814 0,13116222 ! neuron fate specification GO:0048665 11 10 0,000 0,07407814 0,13106132 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07407814 0,13096058 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07407814 0,13086 ! thyroid gland development GO:0030878 19 10 0,000 0,07407814 0,13075957 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07407814 0,1306593 ! synapsis GO:0007129 13 10 0,000 0,07407814 0,13055917 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07407814 0,1304592 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07407814 0,13035939 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,07407814 0,13025973 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07407814 0,13016021 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07407814 0,13006086 ! androgen metabolic process GO:0008209 13 10 0,000 0,07407814 0,12996165 ! phospholipid efflux GO:0033700 16 10 0,000 0,07407814 0,12986259 ! hippocampus development GO:0021766 19 10 0,000 0,07407814 0,12976369 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07407814 0,12966493 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07407814 0,12956633 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07407814 0,12946787 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07407814 0,12936957 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07407814 0,12927141 ! pathogenesis GO:0009405 13 10 0,000 0,07407814 0,1291734 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07407814 0,12907555 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07407814 0,12897784 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07407814 0,12888027 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07407814 0,12878286 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07407814 0,12868559 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07407814 0,12858847 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07407814 0,12849149 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07407814 0,12839467 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07407814 0,12829798 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07407814 0,12820145 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07407814 0,12810505 ! forebrain cell migration GO:0021885 17 10 0,000 0,07407814 0,12800881 ! lipid digestion GO:0044241 15 10 0,000 0,07407814 0,1279127 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07407814 0,12781674 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07407814 0,12772093 ! UV protection GO:0009650 14 10 0,000 0,07407814 0,12762526 ! entry into host cell GO:0030260 20 10 0,000 0,07407814 0,12752973 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07407814 0,12743435 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07407814 0,1273391 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07407814 0,127244 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07407814 0,12714905 ! regulation of organ growth GO:0046620 11 10 0,000 0,07407814 0,12705423 ! response to dsRNA GO:0043331 18 10 0,000 0,07407814 0,12695955 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07407814 0,12686502 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07407814 0,12677063 ! embryonic axis specification GO:0000578 12 10 0,000 0,07407814 0,12667637 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07407814 0,12658226 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07407814 0,12648829 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07407814 0,12639445 ! fucose catabolic process GO:0019317 16 10 0,000 0,07407814 0,12630076 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07407814 0,1262072 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07407814 0,12611378 ! protein sumoylation GO:0016925 12 10 0,000 0,07407814 0,1260205 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07407814 0,12592736 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07407814 0,12583436 ! zymogen activation GO:0031638 14 10 0,000 0,07407814 0,12574149 ! salivary gland development GO:0007431 22 10 0,000 0,07407814 0,12564876 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07407814 0,12555617 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07407814 0,12546371 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07407814 0,12537139 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07407814 0,12527921 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07407814 0,12518716 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07407814 0,12509524 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07407814 0,12500346 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07407814 0,12491182 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07407814 0,12482031 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07407814 0,12472893 ! detection of bacterium GO:0016045 10 10 0,000 0,07407814 0,12463769 ! embryonic gut development GO:0048566 11 10 0,000 0,07407814 0,12454658 ! activation of innate immune response GO:0002218 10 10 0,000 0,07407814 0,1244556 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07407814 0,12436476 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07407814 0,12427405 ! developmental induction GO:0031128 13 10 0,000 0,07407814 0,12418347 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07407814 0,12409302 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07407814 0,12400271 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07407814 0,12391252 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,07520152 0,12570022 ! activation of MAPK activity GO:0000187 84 59 1,000 0,07520152 0,12560894 ! lung development GO:0030324 94 59 1,000 0,07520152 0,12551778 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,07741666 0,12912134 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07741666 0,12902777 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,07741666 0,12893434 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,07965228 0,13256168 ! extracellular matrix organization GO:0030198 103 61 1,000 0,07965228 0,13246583 ! rRNA transcription GO:0009303 17 11 0,000 0,08117942 0,13490799 ! respiratory burst GO:0045730 14 11 0,000 0,08117942 0,13481059 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08117942 0,13471332 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,08117942 0,13461619 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08117942 0,13451921 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,08117942 0,13442236 ! filopodium assembly GO:0046847 19 11 0,000 0,08117942 0,13432565 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08117942 0,13422909 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08117942 0,13413266 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,08117942 0,13403637 ! mating GO:0007618 14 11 0,000 0,08117942 0,13394022 ! T cell proliferation GO:0042098 20 11 0,000 0,08117942 0,1338442 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08117942 0,13374832 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,08117942 0,13365258 ! bone resorption GO:0045453 16 11 0,000 0,08117942 0,13355698 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08117942 0,13346152 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08117942 0,13336619 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,08117942 0,13327099 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08117942 0,13317593 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,08117942 0,13308101 ! syncytium formation GO:0006949 15 11 0,000 0,08117942 0,13298623 ! plasma membrane organization GO:0007009 18 11 0,000 0,08117942 0,13289157 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08117942 0,13279706 ! mitotic spindle organization GO:0007052 15 11 0,000 0,08117942 0,13270267 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08117942 0,13260842 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08117942 0,13251431 ! adult heart development GO:0007512 11 11 0,000 0,08117942 0,13242033 ! temperature homeostasis GO:0001659 16 11 0,000 0,08117942 0,13232648 ! L-glutamate transport GO:0015813 16 11 0,000 0,08117942 0,13223276 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,08117942 0,13213918 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08117942 0,13204573 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08117942 0,13195241 ! stem cell development GO:0048864 29 11 0,000 0,08117942 0,13185922 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08117942 0,13176617 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08117942 0,13167324 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08117942 0,13158045 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08117942 0,13148779 ! vasoconstriction GO:0042310 15 11 0,000 0,08117942 0,13139526 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08117942 0,13130286 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08117942 0,13121058 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08117942 0,13111844 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08117942 0,13102643 ! ribosome assembly GO:0042255 13 11 0,000 0,08117942 0,13093454 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08117942 0,13084279 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08117942 0,13075116 ! chromatin silencing GO:0006342 19 11 0,000 0,08117942 0,13065966 ! nucleosome positioning GO:0016584 13 11 0,000 0,08117942 0,13056829 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08117942 0,13047705 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,08117942 0,13038594 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08117942 0,13029495 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08117942 0,13020409 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08117942 0,13011335 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08117942 0,13002274 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08117942 0,12993226 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08117942 0,12984191 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08117942 0,12975168 ! male genitalia development GO:0030539 13 11 0,000 0,08117942 0,12966157 ! cholesterol efflux GO:0033344 19 11 0,000 0,08117942 0,12957159 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08117942 0,12948173 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08117942 0,129392 ! germ cell migration GO:0008354 18 11 0,000 0,08117942 0,1293024 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08117942 0,12921291 ! defense response to fungus GO:0050832 12 11 0,000 0,08117942 0,12912355 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08117942 0,12903432 ! lysogeny GO:0030069 18 11 0,000 0,08117942 0,12894521 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08117942 0,12885622 ! acrosome reaction GO:0007340 13 11 0,000 0,08117942 0,12876735 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08117942 0,12867861 ! respiratory tube development GO:0030323 99 62 1,000 0,08190793 0,12974397 ! organelle localization GO:0051640 96 62 1,000 0,08190793 0,12965468 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,08418319 0,13316461 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,08418319 0,13307309 ! viral reproduction GO:0016032 92 63 1,000 0,08418319 0,13298169 ! regulation of lipase activity GO:0060191 109 63 1,000 0,08418319 0,13289042 ! respiratory system development GO:0060541 100 64 1,000 0,08647763 0,13641876 ! adaptive immune response GO:0002250 94 64 1,000 0,08647763 0,13632526 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! lactation GO:0007595 20 12 0,000 0,08822664 0,13898717 ! reproductive cellular process GO:0048610 14 12 0,000 0,08822664 0,13889204 ! tRNA modification GO:0006400 14 12 0,000 0,08822664 0,13879703 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08822664 0,13870216 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08822664 0,13860742 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08822664 0,13851281 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08822664 0,13841832 ! non-recombinational repair GO:0000726 19 12 0,000 0,08822664 0,13832397 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08822664 0,13822974 ! peroxisomal transport GO:0043574 21 12 0,000 0,08822664 0,13813565 ! cartilage condensation GO:0001502 18 12 0,000 0,08822664 0,13804168 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08822664 0,13794783 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08822664 0,13785412 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08822664 0,13776053 ! heart looping GO:0001947 15 12 0,000 0,08822664 0,13766707 ! palate development GO:0060021 15 12 0,000 0,08822664 0,13757374 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08822664 0,13748053 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08822664 0,13738745 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08822664 0,13729449 ! arginine metabolic process GO:0006525 13 12 0,000 0,08822664 0,13720167 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08822664 0,13710896 ! methionine metabolic process GO:0006555 13 12 0,000 0,08822664 0,13701638 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08822664 0,13692393 ! Golgi organization GO:0007030 18 12 0,000 0,08822664 0,1368316 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08822664 0,1367394 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08822664 0,13664732 ! monoamine transport GO:0015844 13 12 0,000 0,08822664 0,13655536 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08822664 0,13646353 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08822664 0,13637182 ! L-amino acid transport GO:0015807 20 12 0,000 0,08822664 0,13628023 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08822664 0,13618877 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08822664 0,13609743 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08822664 0,13600621 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08822664 0,13591511 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08822664 0,13582414 ! cerebellum development GO:0021549 13 12 0,000 0,08822664 0,13573329 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08822664 0,13564256 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08822664 0,13555195 ! histone methylation GO:0016571 15 12 0,000 0,08822664 0,13546146 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08822664 0,13537109 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08822664 0,13528084 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08822664 0,13519072 ! intestinal absorption GO:0050892 19 12 0,000 0,08822664 0,13510071 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08822664 0,13501082 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08822664 0,13492105 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08822664 0,1348314 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08822664 0,13474187 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08822664 0,13465246 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08822664 0,13456317 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08822664 0,134474 ! microspike assembly GO:0030035 23 12 0,000 0,08822664 0,13438494 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08822664 0,134296 ! response to cold GO:0009409 14 12 0,000 0,08822664 0,13420718 ! regulation of caspase activity GO:0043281 97 65 1,000 0,08879083 0,13497614 ! axon guidance GO:0007411 99 66 1,000 0,09112236 0,13842895 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,09347182 0,14190441 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,09347182 0,1418108 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,0952202 0,14436814 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,0952202 0,14427304 ! cGMP metabolic process GO:0046068 16 13 0,000 0,0952202 0,14417806 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,0952202 0,1440832 ! water transport GO:0006833 17 13 0,000 0,0952202 0,14398847 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,0952202 0,14389387 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,0952202 0,14379939 ! lipid localization GO:0010876 24 13 0,000 0,0952202 0,14370503 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,0952202 0,1436108 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,0952202 0,14351669 ! organelle fusion GO:0048284 28 13 0,000 0,0952202 0,1434227 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,0952202 0,14332884 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,0952202 0,1432351 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,0952202 0,14314148 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,0952202 0,14304799 ! response to hexose stimulus GO:0009746 19 13 0,000 0,0952202 0,14295461 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,0952202 0,14286136 ! glutamate metabolic process GO:0006536 18 13 0,000 0,0952202 0,14276823 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,0952202 0,14267522 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,0952202 0,14258234 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,0952202 0,14248957 ! exocrine system development GO:0035272 27 13 0,000 0,0952202 0,14239692 ! bone mineralization GO:0030282 15 13 0,000 0,0952202 0,1423044 ! regulation of exocytosis GO:0017157 17 13 0,000 0,0952202 0,14221199 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,0952202 0,14211971 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,0952202 0,14202754 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,0952202 0,1419355 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,0952202 0,14184357 ! genitalia development GO:0048806 15 13 0,000 0,0952202 0,14175176 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,0952202 0,14166007 ! tissue regeneration GO:0042246 21 13 0,000 0,0952202 0,1415685 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,0952202 0,14147705 ! cofactor transport GO:0051181 19 13 0,000 0,0952202 0,14138571 ! NADP metabolic process GO:0006739 18 13 0,000 0,0952202 0,1412945 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,0952202 0,1412034 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,0952202 0,14111242 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0952202 0,14102155 ! gas transport GO:0015669 18 13 0,000 0,0952202 0,1409308 ! regulation of RNA stability GO:0043487 28 13 0,000 0,0952202 0,14084017 ! heme biosynthetic process GO:0006783 20 13 0,000 0,0952202 0,14074966 ! regulation of axon extension GO:0030516 23 13 0,000 0,0952202 0,14065926 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,0952202 0,14056898 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,0952202 0,14047881 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,0952202 0,14038876 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,0952202 0,14029883 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,0952202 0,14020901 ! rhythmic process GO:0048511 105 68 1,000 0,0958388 0,14102958 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,09822289 0,14444543 ! response to metal ion GO:0010038 103 70 1,000 0,10062371 0,14788149 ! humoral immune response GO:0006959 86 70 1,000 0,10062371 0,14778706 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,10216053 0,14994844 ! superoxide anion generation GO:0042554 18 14 0,000 0,10216053 0,14985281 ! neuron maturation GO:0042551 21 14 0,000 0,10216053 0,1497573 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10216053 0,14966192 ! myotube differentiation GO:0014902 21 14 0,000 0,10216053 0,14956665 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,10216053 0,14947151 ! inositol metabolic process GO:0006020 20 14 0,000 0,10216053 0,14937649 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10216053 0,14928158 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10216053 0,1491868 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10216053 0,14909214 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10216053 0,1489976 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10216053 0,14890318 ! response to cAMP GO:0051591 19 14 0,000 0,10216053 0,14880887 ! limbic system development GO:0021761 25 14 0,000 0,10216053 0,14871469 ! startle response GO:0001964 21 14 0,000 0,10216053 0,14862063 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,10216053 0,14852668 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10216053 0,14843286 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10216053 0,14833915 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10216053 0,14824556 ! glycine metabolic process GO:0006544 22 14 0,000 0,10216053 0,14815209 ! pituitary gland development GO:0021983 23 14 0,000 0,10216053 0,14805873 ! lysosomal transport GO:0007041 20 14 0,000 0,10216053 0,1479655 ! regulation of heart rate GO:0002027 23 14 0,000 0,10216053 0,14787238 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10216053 0,14777938 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10216053 0,14768649 ! embryo implantation GO:0007566 27 14 0,000 0,10216053 0,14759373 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10216053 0,14750107 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10216053 0,14740854 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,10216053 0,14731612 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,10216053 0,14722382 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10216053 0,14713163 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10216053 0,14703956 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10216053 0,1469476 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10216053 0,14685576 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10216053 0,14676403 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10216053 0,14667242 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10216053 0,14658092 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10216053 0,14648953 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,10216053 0,14639826 ! muscle maintenance GO:0046716 19 14 0,000 0,10216053 0,14630711 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10216053 0,14621606 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10216053 0,14612513 ! cell killing GO:0001906 20 14 0,000 0,10216053 0,14603431 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,10216053 0,14594361 ! cilium assembly GO:0042384 20 14 0,000 0,10216053 0,14585302 ! peptide hormone secretion GO:0030072 23 14 0,000 0,10216053 0,14576254 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,10547395 0,15039683 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,10547395 0,15030365 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10904801 0,15530057 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10904801 0,15520446 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10904801 0,15510848 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10904801 0,15501262 ! skin development GO:0043588 25 15 0,000 0,10904801 0,15491687 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10904801 0,15482124 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10904801 0,15472573 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10904801 0,15463034 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10904801 0,15453507 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10904801 0,15443991 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10904801 0,15434487 ! adult walking behavior GO:0007628 25 15 0,000 0,10904801 0,15424995 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10904801 0,15415514 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10904801 0,15406045 ! myoblast differentiation GO:0045445 27 15 0,000 0,10904801 0,15396588 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10904801 0,15387142 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,10904801 0,15377708 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10904801 0,15368285 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10904801 0,15358874 ! cerebral cortex development GO:0021987 29 15 0,000 0,10904801 0,15349475 ! response to osmotic stress GO:0006970 22 15 0,000 0,10904801 0,15340086 ! vesicle coating GO:0006901 25 15 0,000 0,10904801 0,1533071 ! DNA integration GO:0015074 22 15 0,000 0,10904801 0,15321345 ! peptide secretion GO:0002790 27 15 0,000 0,10904801 0,15311991 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10904801 0,15302649 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10904801 0,15293318 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10904801 0,15283998 ! neuron recognition GO:0008038 22 15 0,000 0,10904801 0,1527469 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,10904801 0,15265393 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10904801 0,15256108 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10904801 0,15246834 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10904801 0,15237571 ! biomineral formation GO:0031214 18 15 0,000 0,10904801 0,15228319 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10904801 0,15219078 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10904801 0,15209849 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10904801 0,15200631 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10904801 0,15191424 ! organic cation transport GO:0015695 19 15 0,000 0,10904801 0,15182228 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10904801 0,15173044 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10904801 0,1516387 ! peptide hormone processing GO:0016486 19 15 0,000 0,10904801 0,15154708 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,11038645 0,15331451 ! response to inorganic substance GO:0010035 115 75 1,000 0,1128651 0,15666248 ! protein secretion GO:0009306 27 16 0,000 0,11588304 0,16075452 ! hormone secretion GO:0046879 25 16 0,000 0,11588304 0,16065762 ! bone remodeling GO:0046849 24 16 0,000 0,11588304 0,16056084 ! endothelial cell migration GO:0043542 22 16 0,000 0,11588304 0,16046418 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11588304 0,16036763 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11588304 0,16027119 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11588304 0,16017488 ! glial cell development GO:0021782 24 16 0,000 0,11588304 0,16007868 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11588304 0,15998259 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11588304 0,15988662 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11588304 0,15979076 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11588304 0,15969502 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11588304 0,1595994 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11588304 0,15950389 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11588304 0,15940849 ! fructose metabolic process GO:0006000 20 16 0,000 0,11588304 0,15931321 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11588304 0,15921804 ! protein export from nucleus GO:0006611 24 16 0,000 0,11588304 0,15912298 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11588304 0,15902804 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11588304 0,15893321 ! DNA replication initiation GO:0006270 25 16 0,000 0,11588304 0,1588385 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11588304 0,15874389 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11588304 0,1586494 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11588304 0,15855502 ! diencephalon development GO:0021536 25 16 0,000 0,11588304 0,15846076 ! neural crest cell migration GO:0001755 24 16 0,000 0,11588304 0,1583666 ! G1 phase GO:0051318 27 16 0,000 0,11588304 0,15827256 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11588304 0,15817863 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11588304 0,15808481 ! steroid catabolic process GO:0006706 22 16 0,000 0,11588304 0,15799111 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,11588304 0,15789751 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11588304 0,15780402 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11588304 0,15771065 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11588304 0,15761738 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11588304 0,15752423 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11588304 0,15743118 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11588304 0,15733825 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11588304 0,15724543 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,11786537 0,15984101 ! protein ubiquitination GO:0016567 125 77 1,000 0,11786537 0,15974682 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,11786537 0,15965274 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,11786537 0,15955878 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,12038628 0,16287555 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12266603 0,16586236 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,12266603 0,16576491 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12266603 0,16566757 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,12266603 0,16557035 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12266603 0,16547324 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,12266603 0,16537624 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,12266603 0,16527936 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12266603 0,16518259 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12266603 0,16508594 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,12266603 0,1649894 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12266603 0,16489297 ! memory GO:0007613 25 17 0,000 0,12266603 0,16479665 ! keratinization GO:0031424 17 17 0,000 0,12266603 0,16470045 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12266603 0,16460436 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,12266603 0,16450838 ! retinoid metabolic process GO:0001523 22 17 0,000 0,12266603 0,16441251 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12266603 0,16431676 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12266603 0,16422111 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12266603 0,16412558 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12266603 0,16403016 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,12266603 0,16393485 ! membrane budding GO:0006900 29 17 0,000 0,12266603 0,16383964 ! heme metabolic process GO:0042168 27 17 0,000 0,12266603 0,16374456 ! body fluid secretion GO:0007589 27 17 0,000 0,12266603 0,16364958 ! stem cell differentiation GO:0048863 36 17 0,000 0,12266603 0,16355471 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12266603 0,16345995 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12266603 0,1633653 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12266603 0,16327076 ! sensory perception of pain GO:0019233 23 17 0,000 0,12266603 0,16317633 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,12266603 0,163082 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12266603 0,16298779 ! synaptogenesis GO:0007416 24 17 0,000 0,12266603 0,16289369 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12266603 0,16279969 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,12266603 0,16270581 ! cell-cell junction organization GO:0045216 25 17 0,000 0,12266603 0,16261203 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,12266603 0,16251836 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12266603 0,16242479 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,12266603 0,16233134 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,12266603 0,16223799 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,12292055 0,16248119 ! cellular respiration GO:0045333 107 79 1,000 0,12292055 0,16238786 ! regulation of lyase activity GO:0051339 133 79 1,000 0,12292055 0,16229465 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,12802782 0,1689409 ! response to protein stimulus GO:0051789 111 81 1,000 0,12802782 0,16884403 ! regulation of neurological system process GO:0031644 122 81 1,000 0,12802782 0,16874728 ! vitamin metabolic process GO:0006766 103 81 1,000 0,12802782 0,16865063 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,12802782 0,16855409 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of translation GO:0045727 28 18 0,000 0,12939736 0,17025969 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12939736 0,17016234 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12939736 0,17006511 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12939736 0,16996798 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12939736 0,16987097 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12939736 0,16977407 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12939736 0,16967727 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12939736 0,16958059 ! axis specification GO:0009798 26 18 0,000 0,12939736 0,16948402 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12939736 0,16938756 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12939736 0,1692912 ! pancreas development GO:0031016 26 18 0,000 0,12939736 0,16919496 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12939736 0,16909883 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12939736 0,1690028 ! response to retinoic acid GO:0032526 25 18 0,000 0,12939736 0,16890689 ! pigmentation during development GO:0048066 31 18 0,000 0,12939736 0,16881108 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12939736 0,16871538 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,12939736 0,16861979 ! fucose metabolic process GO:0006004 26 18 0,000 0,12939736 0,16852431 ! response to fungus GO:0009620 19 18 0,000 0,12939736 0,16842894 ! peptide cross-linking GO:0018149 31 18 0,000 0,12939736 0,16833367 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12939736 0,16823852 ! heart process GO:0003015 27 18 0,000 0,12939736 0,16814347 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12939736 0,16804852 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12939736 0,16795369 ! visual learning GO:0008542 35 18 0,000 0,12939736 0,16785896 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12939736 0,16776434 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12939736 0,16766982 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12939736 0,16757542 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12939736 0,16748111 ! vitamin transport GO:0051180 24 18 0,000 0,12939736 0,16738692 ! hormone transport GO:0009914 27 18 0,000 0,12939736 0,16729283 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12939736 0,16719884 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12939736 0,16710496 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12939736 0,16701119 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12939736 0,16691752 ! cell-cell recognition GO:0009988 20 18 0,000 0,12939736 0,16682396 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12939736 0,1667305 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12939736 0,16663714 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,13318445 0,17141815 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13607743 0,17504368 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13607743 0,17494584 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13607743 0,1748481 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13607743 0,17475047 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13607743 0,17465296 ! sensory perception of taste GO:0050909 23 19 0,000 0,13607743 0,17455555 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13607743 0,17445825 ! peroxisome organization GO:0007031 29 19 0,000 0,13607743 0,17436106 ! digestive system process GO:0022600 30 19 0,000 0,13607743 0,17426398 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13607743 0,174167 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13607743 0,17407013 ! response to vitamin A GO:0033189 26 19 0,000 0,13607743 0,17397337 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13607743 0,17387672 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13607743 0,17378018 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,13607743 0,17368374 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,13607743 0,17358741 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13607743 0,17349119 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13607743 0,17339507 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,13607743 0,17329906 ! cytolysis GO:0019835 20 19 0,000 0,13607743 0,17320315 ! vasodilation GO:0042311 33 19 0,000 0,13607743 0,17310736 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13607743 0,17301166 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13607743 0,17291608 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13607743 0,1728206 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13607743 0,17272522 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13607743 0,17262995 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13607743 0,17253478 ! sarcomere organization GO:0045214 23 19 0,000 0,13607743 0,17243972 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,13607743 0,17234477 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13607743 0,17224992 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13607743 0,17215517 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13607743 0,17206053 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13607743 0,17196599 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13607743 0,17187155 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13607743 0,17177722 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,13838776 0,17459784 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,14100611 0,17780376 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,14270663 0,17984945 ! iron ion transport GO:0006826 37 20 0,000 0,14270663 0,17975096 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,14270663 0,17965257 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,14270663 0,17955429 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,14270663 0,17945612 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,14270663 0,17935806 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,14270663 0,1792601 ! spinal cord development GO:0021510 31 20 0,000 0,14270663 0,17916225 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,14270663 0,17906451 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,14270663 0,17896687 ! chromosome condensation GO:0030261 31 20 0,000 0,14270663 0,17886934 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,14270663 0,17877192 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,14270663 0,1786746 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,14270663 0,17857739 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,14270663 0,17848029 ! pallium development GO:0021543 38 20 0,000 0,14270663 0,17838329 ! DNA modification GO:0006304 28 20 0,000 0,14270663 0,17828639 ! collagen fibril organization GO:0030199 45 20 0,000 0,14270663 0,1781896 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,14270663 0,17809292 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,14270663 0,17799634 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,14270663 0,17789986 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,14270663 0,17780349 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,14270663 0,17770723 ! actin filament-based movement GO:0030048 34 20 0,000 0,14270663 0,17761106 ! female pregnancy GO:0007565 130 87 1,000 0,14363517 0,17867003 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,14363517 0,17857345 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,14892412 0,18504888 ! regulation of T cell activation GO:0050863 128 89 1,000 0,14892412 0,18494897 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,14928533 0,1852975 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14928533 0,18519755 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14928533 0,18509772 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14928533 0,18499799 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14928533 0,18489837 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14928533 0,18479885 GO:0009799|determination of symmetry, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,14928533 0,18469944 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14928533 0,18460014 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14928533 0,18450095 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14928533 0,18440186 ! vesicle docking GO:0048278 27 21 0,000 0,14928533 0,18430288 ! phototransduction GO:0007602 25 21 0,000 0,14928533 0,184204 ! dendrite development GO:0016358 35 21 0,000 0,14928533 0,18410524 ! visual behavior GO:0007632 39 21 0,000 0,14928533 0,18400657 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14928533 0,18390801 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14928533 0,18380956 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14928533 0,18371122 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14928533 0,18361298 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14928533 0,18351484 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14928533 0,18341681 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14928533 0,18331888 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14928533 0,18322106 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14928533 0,18312334 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14928533 0,18302573 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14928533 0,18292822 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14928533 0,18283081 ! fatty acid transport GO:0015908 30 21 0,000 0,14928533 0,18273351 ! immunoglobulin production GO:0002377 33 21 0,000 0,14928533 0,18263631 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,14928533 0,18253922 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14928533 0,18244222 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14928533 0,18234533 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14928533 0,18224855 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14928533 0,18215186 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14928533 0,18205528 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14928533 0,1819588 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14928533 0,18186243 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14928533 0,18176615 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14928533 0,18166998 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14928533 0,18157391 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,15158341 0,18427159 ! response to virus GO:0009615 122 91 1,000 0,15425217 0,1874168 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,15581393 0,18921438 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15581393 0,18911453 ! viral genome replication GO:0019079 29 22 0,000 0,15581393 0,18901478 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15581393 0,18891514 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15581393 0,18881561 ! leukocyte adhesion GO:0007159 38 22 0,000 0,15581393 0,18871618 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15581393 0,18861686 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,15581393 0,18851764 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15581393 0,18841852 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15581393 0,18831951 ! lysosome organization GO:0007040 37 22 0,000 0,15581393 0,1882206 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15581393 0,1881218 GO:0051693|actin filament capping, ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15581393 0,1880231 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15581393 0,1879245 ! membrane depolarization GO:0051899 35 22 0,000 0,15581393 0,18782601 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15581393 0,18772762 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15581393 0,18762933 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15581393 0,18753115 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15581393 0,18743307 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,15581393 0,18733509 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,1569301 0,18857849 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,1569301 0,18848002 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,16229279 0,19481911 ! neuron fate commitment GO:0048663 32 23 0,000 0,16229279 0,19471748 ! embryonic pattern specification GO:0009880 31 23 0,000 0,16229279 0,19461596 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,16229279 0,19451454 ! vesicle targeting GO:0006903 32 23 0,000 0,16229279 0,19441324 ! osteoblast differentiation GO:0001649 40 23 0,000 0,16229279 0,19431203 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,16229279 0,19421093 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,16229279 0,19410994 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,16229279 0,19400905 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,16229279 0,19390827 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16229279 0,19380759 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16229279 0,19370701 ! cell fate determination GO:0001709 45 23 0,000 0,16229279 0,19360654 ! pentose metabolic process GO:0019321 31 23 0,000 0,16229279 0,19350617 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,16229279 0,19340591 ! spermatid development GO:0007286 33 23 0,000 0,16229279 0,19330575 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16229279 0,1932057 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,16229279 0,19310575 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16229279 0,1930059 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,16229279 0,19290616 ! telomere organization GO:0032200 32 23 0,000 0,16229279 0,19280651 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16229279 0,19270698 ! regulation of amine transport GO:0051952 38 23 0,000 0,16229279 0,19260754 ! liver development GO:0001889 40 23 0,000 0,16229279 0,19250821 ! response to oxidative stress GO:0006979 141 94 1,000 0,16231231 0,19243212 ! angiogenesis GO:0001525 149 95 1,000 0,165016 0,19553674 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,16772772 0,19864766 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16872229 0,19972274 ! initiation of viral infection GO:0019059 42 24 0,000 0,16872229 0,19962 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16872229 0,19951737 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16872229 0,19941484 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16872229 0,19931242 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,16872229 0,1992101 ! fat cell differentiation GO:0045444 37 24 0,000 0,16872229 0,19910789 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16872229 0,19900578 ! sperm motility GO:0030317 27 24 0,000 0,16872229 0,19890378 ! vacuole organization GO:0007033 39 24 0,000 0,16872229 0,19880188 ! neural crest cell development GO:0014032 39 24 0,000 0,16872229 0,19870009 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16872229 0,1985984 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16872229 0,19849682 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16872229 0,19839534 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,16872229 0,19829396 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16872229 0,19819269 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,16872229 0,19809151 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,16872229 0,19799045 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16872229 0,19788948 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,17044717 0,19981065 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17510282 0,20516377 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17510282 0,20505931 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17510282 0,20495495 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17510282 0,20485071 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,17510282 0,20474656 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,17510282 0,20464252 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17510282 0,20453859 ! peptide transport GO:0015833 43 25 0,000 0,17510282 0,20443476 ! iron ion homeostasis GO:0055072 39 25 0,000 0,17510282 0,20433104 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,17510282 0,20422743 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17510282 0,20412392 ! phospholipid transport GO:0015914 35 25 0,000 0,17510282 0,20402051 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17510282 0,20391721 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17510282 0,20381401 ! detection of light stimulus GO:0009583 30 25 0,000 0,17510282 0,20371092 ! regulation of translation GO:0006417 151 100 1,000 0,17864924 0,20773167 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,17864924 0,20762671 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,18143473 0,21075752 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,18143473 0,21065113 ! translational initiation GO:0006413 43 26 0,000 0,18143473 0,21054485 ! circadian rhythm GO:0007623 42 26 0,000 0,18143473 0,21043867 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,18143473 0,21033261 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,18143473 0,21022664 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,18143473 0,21012079 ! spermatid differentiation GO:0048515 36 26 0,000 0,18143473 0,21001504 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,18143473 0,2099094 ! regulation of coagulation GO:0050818 39 26 0,000 0,18143473 0,20980387 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,1877184 0,21696097 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,1877184 0,216852 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,1877184 0,21674314 ! membrane docking GO:0022406 39 27 0,000 0,1877184 0,21663439 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,1877184 0,21652574 ! catechol metabolic process GO:0009712 43 27 0,000 0,1877184 0,21641721 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,1877184 0,21630878 ! acute-phase response GO:0006953 42 27 0,000 0,1877184 0,21620047 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,1877184 0,21609226 ! myofibril assembly GO:0030239 36 27 0,000 0,1877184 0,21598416 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,1877184 0,21587616 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,1877184 0,21576828 ! natural killer cell activation GO:0030101 35 27 0,000 0,1877184 0,2156605 ! lipid oxidation GO:0034440 38 27 0,000 0,1877184 0,21555284 GO:0019395|fatty acid oxidation, ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,1877184 0,21544527 ! gene silencing GO:0016458 41 27 0,000 0,1877184 0,21533782 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,1939542 0,22238018 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,1939542 0,22226938 ! phenol metabolic process GO:0018958 44 28 0,000 0,1939542 0,22215869 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,1939542 0,22204811 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,1939542 0,22193764 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,1939542 0,22182727 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,1939542 0,22171702 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,1939542 0,22160688 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,1939542 0,22149685 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,1939542 0,22138692 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,1939542 0,22127711 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,1939542 0,2211674 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,1939542 0,2210578 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,1939542 0,22094832 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,1939542 0,22083894 ! mesoderm formation GO:0001707 46 28 0,000 0,1939542 0,22072966 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,1939542 0,2206205 ! BMP signaling pathway GO:0030509 40 28 0,000 0,1939542 0,22051144 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,1939542 0,22040249 ! placenta development GO:0001890 37 28 0,000 0,1939542 0,22029365 ! regulation of innate immune response GO:0045088 38 29 0,000 0,20014247 0,22721011 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,20014247 0,22709802 ! protein targeting to membrane GO:0006612 53 29 0,000 0,20014247 0,22698604 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,20014247 0,22687416 ! mismatch repair GO:0006298 34 29 0,000 0,20014247 0,2267624 ! muscle cell development GO:0055001 38 29 0,000 0,20014247 0,22665075 ! formation of primary germ layer GO:0001704 48 29 0,000 0,20014247 0,22653921 ! telencephalon development GO:0021537 52 29 0,000 0,20014247 0,22642778 ! eye morphogenesis GO:0048592 51 29 0,000 0,20014247 0,22631646 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,20014247 0,22620525 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20628359 0,23303156 ! organic anion transport GO:0015711 51 30 0,000 0,20628359 0,23291716 ! cholesterol transport GO:0030301 46 30 0,000 0,20628359 0,23280287 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,20628359 0,23268869 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20628359 0,23257463 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20628359 0,23246068 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,20628359 0,23234684 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20628359 0,23223311 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20628359 0,2321195 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20628359 0,23200599 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,20628359 0,23189259 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,20628359 0,23177931 ! negative regulation of secretion GO:0051048 49 31 0,000 0,2123779 0,23851034 ! glial cell differentiation GO:0010001 55 31 0,000 0,2123779 0,23839394 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,2123779 0,23827765 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,2123779 0,23816147 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,2123779 0,23804541 ! odontogenesis GO:0042476 50 31 0,000 0,2123779 0,23792946 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,2123779 0,23781362 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,2123779 0,2376979 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,2123779 0,23758228 ! cell fate specification GO:0001708 37 31 0,000 0,2123779 0,23746678 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,2123779 0,2373514 ! RNA modification GO:0009451 40 31 0,000 0,2123779 0,23723612 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,21842577 0,24387343 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,21842577 0,24375511 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,21842577 0,24363689 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,21842577 0,24351879 ! vesicle localization GO:0051648 47 32 0,000 0,21842577 0,24340081 ! RNA export from nucleus GO:0006405 44 33 0,000 0,22442754 0,24996772 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,22442754 0,24984673 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,22442754 0,24972586 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,22442754 0,2496051 ! ear morphogenesis GO:0042471 42 33 0,000 0,22442754 0,24948446 ! actomyosin structure organization GO:0031032 43 33 0,000 0,22442754 0,24936394 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,22442754 0,24924353 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,22442754 0,24912324 ! nucleus organization GO:0006997 49 33 0,000 0,22442754 0,24900306 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,22442754 0,248883 ! regulation of proteolysis GO:0030162 50 33 0,000 0,22442754 0,24876306 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,22442754 0,24864323 ! mRNA catabolic process GO:0006402 48 34 0,000 0,23038357 0,25511902 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,23038357 0,25499625 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,23038357 0,2548736 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,23038357 0,25475106 ! feeding behavior GO:0007631 45 34 0,000 0,23038357 0,25462865 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,23038357 0,25450635 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,23038357 0,25438416 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,23038357 0,2542621 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,23038357 0,25414015 ! embryonic organ development GO:0048568 45 34 0,000 0,23038357 0,25401832 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,23038357 0,2538966 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,2362942 0,26028575 ! Notch signaling pathway GO:0007219 56 35 0,000 0,2362942 0,26016116 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,2362942 0,26003668 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,2362942 0,25991232 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,2362942 0,25978808 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,2362942 0,25966395 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,2362942 0,25953995 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,2362942 0,25941606 ! glycogen metabolic process GO:0005977 48 35 0,000 0,2362942 0,2592923 ! protein homooligomerization GO:0051260 52 35 0,000 0,2362942 0,25916865 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,24215977 0,26547543 ! organic ether metabolic process GO:0018904 46 36 0,000 0,24215977 0,26534896 ! tissue remodeling GO:0048771 62 36 0,000 0,24215977 0,2652226 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,24215977 0,26509636 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,24215977 0,26497025 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,24215977 0,26484425 ! glucan metabolic process GO:0044042 49 36 0,000 0,24215977 0,26471838 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,24798062 0,27095269 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,24798062 0,27082404 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,24798062 0,2706955 ! ion transmembrane transport GO:0034220 56 37 0,000 0,24798062 0,27056709 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,24798062 0,2704388 ! regulation of protein secretion GO:0050708 51 37 0,000 0,24798062 0,27031063 ! amino acid activation GO:0043038 52 37 0,000 0,24798062 0,27018258 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,25375709 0,27634532 ! gliogenesis GO:0042063 71 38 0,000 0,25375709 0,27621454 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,25375709 0,27608388 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,25375709 0,27595334 ! phagocytosis GO:0006909 60 38 0,000 0,25375709 0,27582293 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,25948952 0,2819206 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,25948952 0,28178749 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,25948952 0,28165451 ! JNK cascade GO:0007254 54 39 0,000 0,25948952 0,28152165 ! cell growth GO:0016049 61 39 0,000 0,25948952 0,28138892 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,26517825 0,28742223 ! response to calcium ion GO:0051592 58 40 0,000 0,26517825 0,28728684 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,26517825 0,28715159 ! regulation of tube size GO:0035150 60 40 0,000 0,26517825 0,28701646 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,26517825 0,28688145 ! peptide metabolic process GO:0006518 56 40 0,000 0,26517825 0,28674658 ! inner ear development GO:0048839 57 40 0,000 0,26517825 0,28661183 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,26517825 0,28647721 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,26517825 0,28634271 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,26517825 0,28620834 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,26517825 0,2860741 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,27082359 0,29202732 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,27082359 0,29189047 ! striated muscle contraction GO:0006941 62 41 0,000 0,27082359 0,29175375 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,27082359 0,29161717 ! biopolymer methylation GO:0043414 62 41 0,000 0,27082359 0,2914807 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,27082359 0,29134437 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,27642589 0,29723214 ! cellular component disassembly GO:0022411 64 42 0,000 0,27642589 0,29709325 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,27642589 0,29695448 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,27642589 0,29681585 ! excretion GO:0007588 63 42 0,000 0,27642589 0,29667734 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,27642589 0,29653897 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,27642589 0,29640072 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,27642589 0,2962626 ! regulation of cell shape GO:0008360 78 42 0,000 0,27642589 0,29612461 ! neuromuscular process GO:0050905 79 43 0,000 0,28198546 0,30193974 ! tRNA processing GO:0008033 49 43 0,000 0,28198546 0,30179924 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,28198546 0,30165887 ! methylation GO:0032259 64 43 0,000 0,28198546 0,30151862 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,28750263 0,30727512 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,28750263 0,3071324 ! regulation of ion transport GO:0043269 57 44 0,000 0,28750263 0,30698981 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,28750263 0,30684736 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,28750263 0,30670503 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,28750263 0,30656284 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,28750263 0,30642079 ! RNA catabolic process GO:0006401 64 45 0,000 0,29297772 0,31211152 ! regulation of translational initiation GO:0006446 64 45 0,000 0,29297772 0,31196702 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,29297772 0,31182266 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,29297772 0,31167843 ! cell recognition GO:0008037 58 45 0,000 0,29297772 0,31153433 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,29841105 0,31716517 ! cell redox homeostasis GO:0045454 63 46 0,000 0,29841105 0,31701867 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,29841105 0,31687231 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,29841105 0,31672608 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,30380294 0,32230017 ! viral infectious cycle GO:0019058 71 47 0,000 0,30380294 0,32215157 ! endocrine system development GO:0035270 83 47 0,000 0,30380294 0,32200312 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,30380294 0,3218548 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,30380294 0,32170661 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,30380294 0,32155857 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,30380294 0,32141065 ! chloride transport GO:0006821 67 48 0,000 0,30915369 0,32692115 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,30915369 0,32677091 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,30915369 0,32662081 ! gastrulation GO:0007369 73 48 0,000 0,30915369 0,32647084 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,30915369 0,32632102 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,30915369 0,32617133 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,30915369 0,32602178 ! regulation of endocytosis GO:0030100 63 48 0,000 0,30915369 0,32587236 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,30915369 0,32572309 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,31446363 0,33116591 ! sensory perception of smell GO:0007608 61 49 0,000 0,31446363 0,33101435 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,31446363 0,33086292 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,31446363 0,33071164 ! RNA elongation GO:0006354 62 49 0,000 0,31446363 0,33056049 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,31446363 0,33040948 ! regulation of actin filament length GO:0030832 72 50 0,000 0,31973305 0,33579271 ! membrane fusion GO:0006944 80 50 0,000 0,31973305 0,33563945 ! proton transport GO:0015992 75 50 0,000 0,31973305 0,33548632 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,31973305 0,33533334 ! positive regulation of secretion GO:0051047 71 51 0,000 0,32496227 0,34066237 ! hydrogen transport GO:0006818 77 51 0,000 0,32496227 0,34050717 ! adult behavior GO:0030534 80 51 0,000 0,32496227 0,34035211 ! transition metal ion transport GO:0000041 74 52 0,000 0,3301516 0,3456298 ! regulation of cellular component size GO:0032535 74 52 0,000 0,3301516 0,34547255 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,3301516 0,34531545 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,33530132 0,35054229 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,33530132 0,35038302 ! single fertilization GO:0007338 59 53 0,000 0,33530132 0,3502239 ! amino acid transport GO:0006865 84 54 0,000 0,34041175 0,35540037 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,34041175 0,35523912 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,34041175 0,35507801 ! DNA catabolic process GO:0006308 67 54 0,000 0,34041175 0,35491705 ! detection of external stimulus GO:0009581 66 54 0,000 0,34041175 0,35475624 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,34041175 0,35459557 ! exocytosis GO:0006887 74 55 0,000 0,34548317 0,35971539 ! mesoderm development GO:0007498 76 55 0,000 0,34548317 0,35955262 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,34548317 0,35939 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,3505159 0,36446047 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,35551021 0,36948643 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,35551021 0,36931955 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,3604664 0,37429919 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,3604664 0,37413029 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,36538476 0,37906402 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,36538476 0,37889312 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,37026557 0,38378135 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,37026557 0,38360848 ! fertilization GO:0009566 68 60 0,000 0,37026557 0,38343576 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,37510913 0,38827677 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,37510913 0,38810211 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,37510913 0,3879276 ! amine catabolic process GO:0009310 90 62 0,000 0,3799157 0,39272185 ! neurotransmitter transport GO:0006836 81 62 0,000 0,3799157 0,39254543 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,3799157 0,39236916 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,38941904 0,4020035 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,38941904 0,40182315 ! defense response to bacterium GO:0042742 73 65 0,000 0,39411636 0,40648772 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,39411636 0,40630552 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,39411636 0,40612349 ! activation of immune response GO:0002253 83 65 0,000 0,39411636 0,40594161 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,39877781 0,41055907 ! antigen processing and presentation GO:0019882 96 66 0,000 0,39877781 0,41037537 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,39877781 0,41019184 ! regulation of immune effector process GO:0002697 101 66 0,000 0,39877781 0,41000847 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,40340365 0,41457927 ! acute inflammatory response GO:0002526 92 68 0,000 0,40799417 0,41910969 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,40799417 0,41892259 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,40799417 0,41873565 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,40799417 0,41854888 ! inorganic anion transport GO:0015698 93 68 0,000 0,40799417 0,41836228 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,41254963 0,42284499 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,4170703 0,42728806 ! amine transport GO:0015837 101 70 0,000 0,4170703 0,42709781 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,4170703 0,42690774 ! muscle cell differentiation GO:0042692 104 71 0,000 0,42155643 0,43130774 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,42155643 0,43111596 ! regulation of blood pressure GO:0008217 107 73 0,000 0,43042616 0,43999118 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,43042616 0,43979572 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,43481026 0,44407798 ! digestion GO:0007586 97 74 0,000 0,43481026 0,44388087 ! blood coagulation GO:0007596 116 75 0,000 0,43916087 0,44812334 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,43916087 0,44792462 ! amine biosynthetic process GO:0009309 97 76 0,000 0,44347824 0,45212764 ! tRNA metabolic process GO:0006399 95 76 0,000 0,44347824 0,45192732 ! response to unfolded protein GO:0006986 99 76 0,000 0,44347824 0,45172717 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,44347824 0,45152721 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,44776262 0,45568762 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,44776262 0,45548608 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,45201426 0,45960778 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,45623341 0,46369282 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,45623341 0,46348801 ! chromatin assembly GO:0031497 102 80 0,000 0,46042032 0,46753498 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,46042032 0,46732866 ! forebrain development GO:0030900 131 80 0,000 0,46042032 0,46712251 ! hemostasis GO:0007599 125 81 0,000 0,46457522 0,47113008 ! mRNA transport GO:0051028 121 81 0,000 0,46457522 0,47092244 ! detection of stimulus GO:0051606 108 82 0,000 0,46869837 0,47489263 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,47279001 0,4788274 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,47685036 0,48272704 ! sterol metabolic process GO:0016125 120 84 0,000 0,47685036 0,48251467 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,48087968 0,48637786 ! transcription initiation GO:0006352 118 85 0,000 0,48087968 0,48616407 ! nucleosome organization GO:0034728 114 87 0,000 0,48884614 0,49400093 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,48884614 0,49378397 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,48884614 0,49356721 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,49278374 0,49732453 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,49278374 0,4971064 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,49278374 0,49688847 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,49278374 0,49667073 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,49669123 0,50038977 ! RNA localization GO:0006403 135 91 0,000 0,50441681 0,50795038 ! ATP metabolic process GO:0046034 137 91 0,000 0,50441681 0,50772808 ! positive regulation of immune response GO:0050778 121 92 0,000 0,50823535 0,5113479 ! sulfur metabolic process GO:0006790 118 92 0,000 0,50823535 0,51112431 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,51202468 0,51471012 ! electron transport chain GO:0022900 123 94 0,000 0,51578503 0,51826368 ! carboxylic acid transport GO:0046942 147 95 0,000 0,51951661 0,52178524 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,52321965 0,52527508 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,52321965 0,5250459 ! protein maturation GO:0051604 129 96 0,000 0,52321965 0,52481692 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,52689437 0,52827247 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,53415967 0,53532342 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,53775068 0,53868753 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,53775068 0,53845301 ! divalent metal ion transport GO:0070838 171 100 0,000 0,53775068 0,5382187 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,53775068 0,53798459 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,53775068 0,53775068