pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6658-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cell growth GO:0016049 61 39 6,000 7,928E-08 1,824E-04 ! positive regulation of protein complex assembly GO:0031334 19 13 4,000 9,338E-08 1,074E-04 ! inner ear receptor cell differentiation GO:0060113 30 16 4,000 3,096E-07 2,374E-04 ! mechanoreceptor differentiation GO:0042490 32 18 4,000 5,979E-07 3,438E-04 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 4,000 8,051E-07 3,704E-04 ! regulation of protein complex assembly GO:0043254 81 54 6,000 8,088E-07 3,101E-04 ! myeloid leukocyte differentiation GO:0002573 33 21 4,000 1,387E-06 4,558E-04 ! protein sumoylation GO:0016925 12 10 3,000 1,652E-06 4,749E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 5,000 1,807E-06 4,618E-04 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 4,000 2,831E-06 6,511E-04 ! positive regulation of cell cycle GO:0045787 77 45 5,000 4,301E-06 8,993E-04 ! nuclear migration GO:0007097 10 5 2,000 8,595E-06 1,647E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 2,000 8,595E-06 1,521E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 8,595E-06 1,412E-03 GO:0031272|regulation of pseudopodium assembly, ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 9,068E-06 1,39E-03 ! positive regulation of protein ubiquitination GO:0031398 8 6 2,000 1,707E-05 2,454E-03 ! male meiosis GO:0007140 7 6 2,000 1,707E-05 2,309E-03 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 1,707E-05 2,181E-03 ! macrophage differentiation GO:0030225 10 6 2,000 1,707E-05 2,066E-03 ! establishment or maintenance of cell polarity GO:0007163 61 34 4,000 1,715E-05 1,972E-03 ! regulation of protein localization GO:0032880 132 85 6,000 1,756E-05 1,924E-03 ! lung development GO:0030324 94 59 5,000 2,129E-05 2,226E-03 ! myeloid cell differentiation GO:0030099 85 59 5,000 2,129E-05 2,129E-03 ! leukocyte differentiation GO:0002521 143 90 6,000 2,554E-05 2,447E-03 ! respiratory tube development GO:0030323 99 62 5,000 2,837E-05 2,61E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 2,966E-05 2,624E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 2,966E-05 2,527E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 2,966E-05 2,436E-03 ! synaptic vesicle endocytosis GO:0048488 16 7 2,000 2,966E-05 2,352E-03 ! respiratory system development GO:0060541 100 64 5,000 3,405E-05 2,611E-03 ! inner ear development GO:0048839 57 40 4,000 3,87E-05 2,872E-03 ! regulation of cellular component biogenesis GO:0044087 158 96 6,000 3,882E-05 2,791E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 4,712E-05 3,284E-03 ! activation of protein kinase activity GO:0032147 102 69 5,000 5,233E-05 3,54E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 5,532E-05 3,635E-03 ! regulation of gene-specific transcription GO:0032583 69 43 4,000 5,532E-05 3,534E-03 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 5,679E-05 3,53E-03 ! liver development GO:0001889 40 23 3,000 6,318E-05 3,824E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 5,000 6,661E-05 3,928E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 5,000 6,661E-05 3,83E-03 ! artery development GO:0060840 19 9 2,000 7,018E-05 3,937E-03 GO:0048844|artery morphogenesis, ! nucleus localization GO:0051647 15 9 2,000 7,018E-05 3,843E-03 ! response to oxygen levels GO:0070482 137 74 5,000 7,774E-05 4,158E-03 ! gland development GO:0048732 148 77 5,000 9,716E-05 5,079E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 9,955E-05 5,088E-03 ! ear development GO:0043583 72 50 4,000 1,153E-04 5,767E-03 ! negative regulation of transcription regulator activity GO:0090048 47 27 3,000 1,215E-04 5,947E-03 GO:0043433|negative regulation of transcription factor activity, ! double-strand break repair via homologous recombination GO:0000724 16 11 2,000 1,359E-04 6,513E-03 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 2,000 1,359E-04 6,38E-03 ! cell projection assembly GO:0030031 76 53 4,000 1,526E-04 7,021E-03 ! auditory receptor cell differentiation GO:0042491 25 12 2,000 1,799E-04 8,115E-03 ! positive regulation of cell growth GO:0030307 16 12 2,000 1,799E-04 7,959E-03 ! regulation of epidermis development GO:0045682 17 12 2,000 1,799E-04 7,809E-03 ! microspike assembly GO:0030035 23 12 2,000 1,799E-04 7,664E-03 ! positive regulation of gene-specific transcription GO:0043193 47 31 3,000 2,114E-04 8,842E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 2,159E-04 8,868E-03 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 2,000 2,323E-04 9,373E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 2,345E-04 9,298E-03 ! peripheral nervous system development GO:0007422 53 32 3,000 2,398E-04 9,35E-03 ! negative regulation of DNA binding GO:0043392 54 33 3,000 2,709E-04 0,01038436 ! meiosis GO:0007126 96 61 4,000 2,974E-04 0,01121506 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 4,000 2,974E-04 0,01103417 ! negative regulation of transferase activity GO:0051348 105 61 4,000 2,974E-04 0,01085903 ! erythrocyte homeostasis GO:0034101 45 34 3,000 3,047E-04 0,01095123 ! meiotic cell cycle GO:0051321 97 62 4,000 3,21E-04 0,01136009 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 3,415E-04 0,01190036 ! regulation of transcription factor activity GO:0051090 97 63 4,000 3,46E-04 0,01187902 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 3,46E-04 0,01170433 ! regulation of protein ubiquitination GO:0031396 19 15 2,000 3,643E-04 0,01214465 ! positive regulation of cell size GO:0045793 20 15 2,000 3,643E-04 0,01197116 ! negative regulation of cell cycle process GO:0010948 24 15 2,000 3,643E-04 0,01180255 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 3,643E-04 0,01163862 ! dopamine metabolic process GO:0042417 30 15 2,000 3,643E-04 0,01147919 ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 3,643E-04 0,01132407 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 3,725E-04 0,01142274 ! negative regulation of binding GO:0051100 58 36 3,000 3,813E-04 0,01153981 ! patterning of blood vessels GO:0001569 24 16 2,000 4,453E-04 0,01329997 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 2,000 5,369E-04 0,01583067 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 5,369E-04 0,01563028 ! T cell differentiation GO:0030217 65 40 3,000 5,742E-04 0,01650826 ! synaptic vesicle transport GO:0048489 33 18 2,000 6,397E-04 0,01816449 ! estrogen receptor signaling pathway GO:0030520 30 18 2,000 6,397E-04 0,01794298 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 2,000 6,397E-04 0,0177268 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 6,928E-04 0,01897063 ! regulation of DNA binding GO:0051101 119 77 4,000 8,732E-04 0,02362811 ! collagen fibril organization GO:0030199 45 20 2,000 8,812E-04 0,02356649 ! camera-type eye morphogenesis GO:0048593 34 20 2,000 8,812E-04 0,02329562 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 9,007E-04 0,02354209 ! embryonic camera-type eye development GO:0031076 8 5 1,000 9,007E-04 0,02327757 GO:0048596|embryonic camera-type eye morphogenesis, ! embryonic hemopoiesis GO:0035162 10 5 1,000 9,007E-04 0,02301893 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 1,000 9,007E-04 0,02276597 ! endochondral ossification GO:0001958 12 5 1,000 9,007E-04 0,02251852 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of viral genome replication GO:0045070 8 5 1,000 9,007E-04 0,02227638 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 9,007E-04 0,0220394 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! regulation of retroviral genome replication GO:0045091 6 5 1,000 9,007E-04 0,02180741 ! neutrophil mediated immunity GO:0002446 6 5 1,000 9,007E-04 0,02158025 ! microvillus organization GO:0032528 7 5 1,000 9,007E-04 0,02135777 GO:0030033|microvillus assembly, ! early endosome to late endosome transport GO:0045022 11 5 1,000 9,007E-04 0,02113983 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 9,007E-04 0,0209263 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 9,007E-04 0,02071704 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 8 5 1,000 9,007E-04 0,02051192 ! forebrain morphogenesis GO:0048853 13 5 1,000 9,007E-04 0,02031082 ! centrosome duplication GO:0051298 5 5 1,000 9,007E-04 0,02011363 ! response to UV-C GO:0010225 6 5 1,000 9,007E-04 0,01992023 ! positive regulation of chemokine production GO:0032722 7 5 1,000 9,007E-04 0,01973051 ! muscle cell proliferation GO:0033002 8 5 1,000 9,007E-04 0,01954437 ! regulation of hair follicle development GO:0051797 9 5 1,000 9,007E-04 0,01936172 GO:0042634|regulation of hair cycle, ! glial cell migration GO:0008347 10 5 1,000 9,007E-04 0,01918244 ! regulation of sensory perception GO:0051931 6 5 1,000 9,007E-04 0,01900646 GO:0051930|regulation of sensory perception of pain, ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 9,007E-04 0,01883367 GO:0022011|myelination in the peripheral nervous system, ! positive regulation of protein modification process GO:0031401 107 78 4,000 9,259E-04 0,01918468 ! response to UV GO:0009411 75 46 3,000 9,804E-04 0,02013409 ! T cell activation GO:0042110 134 79 4,000 9,809E-04 0,01996425 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 2,000 1,021E-03 0,02059551 ! forebrain development GO:0030900 131 80 4,000 1,038E-03 0,02076451 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 3,000 1,152E-03 0,02283723 ! ossification GO:0001503 134 82 4,000 1,16E-03 0,02281124 GO:0060348|bone development, ! vasculogenesis GO:0001570 33 22 2,000 1,174E-03 0,02287722 ! blastocyst development GO:0001824 37 22 2,000 1,174E-03 0,02268497 ! regulation of intracellular transport GO:0032386 78 49 3,000 1,245E-03 0,02386008 ! osteoblast differentiation GO:0001649 40 23 2,000 1,34E-03 0,02547638 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 1,34E-03 0,02526756 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 1,000 1,343E-03 0,02510509 GO:0045346|regulation of MHC class II biosynthetic process, ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,343E-03 0,02490263 ! prostate gland development GO:0030850 9 6 1,000 1,343E-03 0,02470341 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,343E-03 0,02450735 ! erythrocyte maturation GO:0043249 6 6 1,000 1,343E-03 0,02431438 ! activation of MAPKKK activity GO:0000185 10 6 1,000 1,343E-03 0,02412442 ! histidine metabolic process GO:0006547 6 6 1,000 1,343E-03 0,02393741 GO:0009075|histidine family amino acid metabolic process, ! ER overload response GO:0006983 7 6 1,000 1,343E-03 0,02375328 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,343E-03 0,02357195 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 1,000 1,343E-03 0,02339338 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 1,343E-03 0,02321749 ! astrocyte development GO:0014002 14 6 1,000 1,343E-03 0,02304422 ! DNA topological change GO:0006265 8 6 1,000 1,343E-03 0,02287353 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 1,343E-03 0,02270534 ! Schwann cell development GO:0014044 14 6 1,000 1,343E-03 0,02253961 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,343E-03 0,02237627 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 1,343E-03 0,02221529 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 1,000 1,343E-03 0,02205661 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,343E-03 0,02190018 ! regulation of epidermal cell differentiation GO:0045604 7 6 1,000 1,343E-03 0,02174596 ! blastocyst growth GO:0001832 15 6 1,000 1,343E-03 0,02159389 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 1,436E-03 0,02294035 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,447E-03 0,0229461 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 1,521E-03 0,02396093 ! establishment of organelle localization GO:0051656 85 52 3,000 1,556E-03 0,02433843 ! interphase GO:0051325 159 88 4,000 1,591E-03 0,02472521 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 1,716E-03 0,02649295 GO:0045936|negative regulation of phosphate metabolic process, ! protein modification by small protein conjugation GO:0032446 140 90 4,000 1,758E-03 0,02695112 ! negative regulation of muscle cell differentiation GO:0051148 9 7 1,000 1,868E-03 0,02844907 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,868E-03 0,0282619 ! adrenal gland development GO:0030325 17 7 1,000 1,868E-03 0,02807718 ! vesicle fusion GO:0006906 15 7 1,000 1,868E-03 0,02789487 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,868E-03 0,0277149 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,868E-03 0,02753724 ! positive regulation of epidermis development GO:0045684 11 7 1,000 1,868E-03 0,02736184 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 1,868E-03 0,02718867 GO:0002688|regulation of leukocyte chemotaxis, ! dopamine biosynthetic process GO:0042416 15 7 1,000 1,868E-03 0,02701767 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,868E-03 0,02684881 ! embryonic heart tube development GO:0035050 7 7 1,000 1,868E-03 0,02668204 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,927E-03 0,02735214 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 2,000 1,927E-03 0,02718433 ! positive regulation of cell motion GO:0051272 99 56 3,000 2,049E-03 0,02873034 ! catechol metabolic process GO:0009712 43 27 2,000 2,152E-03 0,02999994 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! negative regulation of protein transport GO:0051224 49 27 2,000 2,152E-03 0,02981922 ! chromosome segregation GO:0007059 83 57 3,000 2,187E-03 0,03011917 ! regulation of binding GO:0051098 151 95 4,000 2,23E-03 0,03053037 ! angiogenesis GO:0001525 149 95 4,000 2,23E-03 0,03034972 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 2,332E-03 0,03154436 ! in utero embryonic development GO:0001701 147 96 4,000 2,335E-03 0,03140117 ! protein modification by small protein conjugation or removal GO:0070647 148 96 4,000 2,335E-03 0,0312186 ! response to light stimulus GO:0009416 153 96 4,000 2,335E-03 0,03103815 ! phenol metabolic process GO:0018958 44 28 2,000 2,394E-03 0,03163881 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 2,394E-03 0,03145801 ! erythrocyte differentiation GO:0030218 38 28 2,000 2,394E-03 0,03127927 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 2,475E-03 0,03215605 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 2,475E-03 0,03197539 GO:0046579|positive regulation of Ras protein signal transduction, ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,475E-03 0,03179676 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,475E-03 0,03162011 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 2,475E-03 0,03144541 ! endothelial cell differentiation GO:0045446 14 8 1,000 2,475E-03 0,03127264 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,475E-03 0,03110175 ! astrocyte differentiation GO:0048708 16 8 1,000 2,475E-03 0,03093272 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 1,000 2,475E-03 0,03076551 ! embryonic eye morphogenesis GO:0048048 12 8 1,000 2,475E-03 0,03060011 ! multicellular organism growth GO:0035264 14 8 1,000 2,475E-03 0,03043647 ! Schwann cell differentiation GO:0014037 17 8 1,000 2,475E-03 0,03027458 ! regulation of gliogenesis GO:0014013 20 8 1,000 2,475E-03 0,03011439 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 1,000 2,475E-03 0,0299559 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 2,475E-03 0,02979906 ! induction of an organ GO:0001759 11 8 1,000 2,475E-03 0,02964385 ! neuromuscular process controlling posture GO:0050884 11 8 1,000 2,475E-03 0,02949026 ! lamellipodium assembly GO:0030032 9 8 1,000 2,475E-03 0,02933825 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 2,475E-03 0,0291878 ! regulation of homeostatic process GO:0032844 105 60 3,000 2,64E-03 0,03098303 ! eye morphogenesis GO:0048592 51 29 2,000 2,651E-03 0,0309511 ! organelle localization GO:0051640 96 62 3,000 2,976E-03 0,03456958 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 3,154E-03 0,03645664 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 3,162E-03 0,03635839 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 3,162E-03 0,0361775 GO:0010469|regulation of receptor activity, ! positive regulation of GTPase activity GO:0043547 21 9 1,000 3,162E-03 0,03599841 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 3,162E-03 0,03582108 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 3,162E-03 0,03564548 ! positive regulation of survival gene product expression GO:0045885 13 9 1,000 3,162E-03 0,0354716 ! myeloid leukocyte mediated immunity GO:0002444 11 9 1,000 3,162E-03 0,03529941 ! DNA ligation GO:0006266 14 9 1,000 3,162E-03 0,03512888 ! erythrocyte development GO:0048821 11 9 1,000 3,162E-03 0,03495999 ! methionine biosynthetic process GO:0009086 10 9 1,000 3,162E-03 0,03479272 ! oocyte differentiation GO:0009994 12 9 1,000 3,162E-03 0,03462704 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 3,162E-03 0,03446293 ! spleen development GO:0048536 15 9 1,000 3,162E-03 0,03430037 ! blastocyst formation GO:0001825 12 9 1,000 3,162E-03 0,03413933 ! embryonic placenta development GO:0001892 12 9 1,000 3,162E-03 0,03397981 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 3,162E-03 0,03382176 ! localization within membrane GO:0051668 15 9 1,000 3,162E-03 0,03366518 ! mitotic sister chromatid segregation GO:0000070 45 32 2,000 3,524E-03 0,03734644 ! meiosis I GO:0007127 52 32 2,000 3,524E-03 0,03717512 ! calcium-mediated signaling GO:0019722 50 32 2,000 3,524E-03 0,03700537 ! regulation of Rho protein signal transduction GO:0035023 111 66 3,000 3,733E-03 0,03902321 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 3,849E-03 0,0400556 ! sister chromatid segregation GO:0000819 46 33 2,000 3,849E-03 0,03987517 ! cytokinesis GO:0000910 52 33 2,000 3,849E-03 0,03969636 ! negative regulation of muscle development GO:0048635 12 10 1,000 3,927E-03 0,04032302 ! thyroid gland development GO:0030878 19 10 1,000 3,927E-03 0,04014381 ! regulation of B cell proliferation GO:0030888 15 10 1,000 3,927E-03 0,03996618 ! regulation of phosphatase activity GO:0010921 21 10 1,000 3,927E-03 0,03979012 ! folic acid and derivative biosynthetic process GO:0009396 10 10 1,000 3,927E-03 0,0396156 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,927E-03 0,0394426 ! blood vessel remodeling GO:0001974 21 10 1,000 3,927E-03 0,03927111 ! positive regulation of heart contraction GO:0045823 14 10 1,000 3,927E-03 0,03910111 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,927E-03 0,03893257 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 3,927E-03 0,03876548 ! response to X-ray GO:0010165 16 10 1,000 3,927E-03 0,03859981 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,927E-03 0,03843556 ! regulation of bone resorption GO:0045124 24 10 1,000 3,927E-03 0,0382727 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 3,927E-03 0,03811121 ! salivary gland development GO:0007431 22 10 1,000 3,927E-03 0,03795108 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 3,927E-03 0,03779229 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 3,927E-03 0,03763482 ! developmental induction GO:0031128 13 10 1,000 3,927E-03 0,03747866 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic organ development GO:0048568 45 34 2,000 4,192E-03 0,0398394 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 4,553E-03 0,04309201 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 4,61E-03 0,04345684 ! eye development GO:0001654 111 70 3,000 4,61E-03 0,04327947 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,77E-03 0,04459381 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 4,77E-03 0,04441327 ! regulation of mRNA processing GO:0050684 18 11 1,000 4,77E-03 0,04423419 ! membrane protein proteolysis GO:0033619 18 11 1,000 4,77E-03 0,04405654 GO:0006509|membrane protein ectodomain proteolysis, ! adult heart development GO:0007512 11 11 1,000 4,77E-03 0,04388031 ! chondrocyte differentiation GO:0002062 17 11 1,000 4,77E-03 0,04370549 ! regulation of interleukin-8 production GO:0032677 17 11 1,000 4,77E-03 0,04353206 ! T cell homeostasis GO:0043029 20 11 1,000 4,77E-03 0,04335999 ! regulation of leukocyte migration GO:0002685 24 11 1,000 4,77E-03 0,04318928 ! acrosome reaction GO:0007340 13 11 1,000 4,77E-03 0,04301991 ! lymphocyte differentiation GO:0030098 113 71 3,000 4,849E-03 0,04356938 ! tube morphogenesis GO:0035239 118 73 3,000 5,353E-03 0,04790362 ! positive regulation of lymphocyte activation GO:0051251 108 74 3,000 5,617E-03 0,05007354 ! reproductive cellular process GO:0048610 14 12 1,000 5,688E-03 0,05050703 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 5,688E-03 0,05031277 ! heart looping GO:0001947 15 12 1,000 5,688E-03 0,05012 ! palate development GO:0060021 15 12 1,000 5,688E-03 0,0499287 ! methionine metabolic process GO:0006555 13 12 1,000 5,688E-03 0,04973886 ! histone acetylation GO:0016573 23 12 1,000 5,688E-03 0,04955046 ! autonomic nervous system development GO:0048483 23 12 1,000 5,688E-03 0,04936347 ! gland morphogenesis GO:0022612 23 12 1,000 5,688E-03 0,0491779 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,688E-03 0,04899371 ! response to gamma radiation GO:0010332 20 12 1,000 5,688E-03 0,0488109 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 5,688E-03 0,04862944 ! gliogenesis GO:0042063 71 38 2,000 5,746E-03 0,04894913 ! regulation of protein transport GO:0051223 114 76 3,000 6,171E-03 0,0523759 GO:0070201|regulation of establishment of protein localization, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 2,000 6,182E-03 0,05227143 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 6,636E-03 0,05591042 ! double-strand break repair GO:0006302 67 40 2,000 6,636E-03 0,05570637 ! B cell differentiation GO:0030183 62 40 2,000 6,636E-03 0,0555038 ! JAK-STAT cascade GO:0007259 53 40 2,000 6,636E-03 0,0553027 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 6,679E-03 0,05546068 ! regulation of chemokine production GO:0032642 17 13 1,000 6,679E-03 0,05526118 ! organelle fusion GO:0048284 28 13 1,000 6,679E-03 0,05506311 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 6,679E-03 0,05486646 ! exocrine system development GO:0035272 27 13 1,000 6,679E-03 0,0546712 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 6,679E-03 0,05447734 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,679E-03 0,05428484 ! neuromuscular synaptic transmission GO:0007274 20 13 1,000 6,679E-03 0,05409369 ! lymphocyte homeostasis GO:0002260 24 13 1,000 6,679E-03 0,05390389 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 7,604E-03 0,06115139 ! embryonic skeletal system development GO:0048706 56 42 2,000 7,604E-03 0,06093832 ! regulation of cell cycle process GO:0010564 122 81 3,000 7,713E-03 0,06159784 ! positive regulation of cell activation GO:0050867 120 81 3,000 7,713E-03 0,0613847 GO:0002696|positive regulation of leukocyte activation, ! regulation of S phase GO:0033261 18 14 1,000 7,744E-03 0,06141559 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 7,744E-03 0,06120453 ! startle response GO:0001964 21 14 1,000 7,744E-03 0,06099493 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 7,744E-03 0,06078676 ! activation of MAPKK activity GO:0000186 21 14 1,000 7,744E-03 0,06058 ! epidermis morphogenesis GO:0048730 29 14 1,000 7,744E-03 0,06037464 ! embryo implantation GO:0007566 27 14 1,000 7,744E-03 0,06017067 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 7,744E-03 0,05996808 ! DNA unwinding during replication GO:0006268 21 14 1,000 7,744E-03 0,05976684 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 7,744E-03 0,05956696 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 7,744E-03 0,0593684 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 7,744E-03 0,05917116 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 7,744E-03 0,05897523 ! neuromuscular process GO:0050905 79 43 2,000 8,117E-03 0,06161782 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 8,117E-03 0,06141513 ! regulation of cell projection organization GO:0031344 83 44 2,000 8,651E-03 0,06523604 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 8,651E-03 0,06502285 ! sulfur amino acid biosynthetic process GO:0000097 17 15 1,000 8,879E-03 0,06652013 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 8,879E-03 0,06630415 ! lipid phosphorylation GO:0046834 23 15 1,000 8,879E-03 0,06608958 ! regulation of neurotransmitter secretion GO:0046928 26 15 1,000 8,879E-03 0,06587639 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 8,879E-03 0,06566456 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 8,879E-03 0,0654541 ! centrosome cycle GO:0007098 16 15 1,000 8,879E-03 0,06524498 ! regulation of survival gene product expression GO:0045884 20 15 1,000 8,879E-03 0,0650372 ! cerebral cortex development GO:0021987 29 15 1,000 8,879E-03 0,06483073 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 8,879E-03 0,06462557 ! folic acid and derivative metabolic process GO:0006760 17 15 1,000 8,879E-03 0,0644217 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 1,000 8,879E-03 0,06421912 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 8,879E-03 0,0640178 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 9,115E-03 0,06551065 ! cell maturation GO:0048469 60 45 2,000 9,204E-03 0,06595028 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 9,204E-03 0,06574546 ! cell cycle arrest GO:0007050 150 86 3,000 9,489E-03 0,06756926 ! protein amino acid acetylation GO:0006473 28 16 1,000 0,01008381 0,0715826 ! glial cell development GO:0021782 24 16 1,000 0,01008381 0,07136235 ! cellular response to hydrogen peroxide GO:0070301 21 16 1,000 0,01008381 0,07114344 GO:0042744|hydrogen peroxide catabolic process, ! regulation of dephosphorylation GO:0035303 33 16 1,000 0,01008381 0,07092588 ! negative regulation of immune response GO:0050777 28 16 1,000 0,01008381 0,07070964 ! ribosomal small subunit biogenesis GO:0042274 18 16 1,000 0,01008381 0,07049472 ! oogenesis GO:0048477 23 16 1,000 0,01008381 0,0702811 ! neutrophil chemotaxis GO:0030593 21 16 1,000 0,01008381 0,07006877 ! response to estrogen stimulus GO:0043627 74 47 2,000 0,01037229 0,07185624 ! endocrine system development GO:0035270 83 47 2,000 0,01037229 0,07164046 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 0,01037229 0,07142596 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 0,01037229 0,07121275 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 2,000 0,01098699 0,07520858 ! heart morphogenesis GO:0003007 65 48 2,000 0,01098699 0,07498541 ! regulation of DNA replication GO:0006275 75 48 2,000 0,01098699 0,07476356 ! signal complex assembly GO:0007172 29 17 1,000 0,01135674 0,0770516 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 0,01135674 0,07682498 ! forelimb morphogenesis GO:0035136 19 17 1,000 0,01135674 0,07659968 ! regulation of viral genome replication GO:0045069 24 17 1,000 0,01135674 0,07637571 ! DNA duplex unwinding GO:0032508 25 17 1,000 0,01135674 0,07615304 GO:0032392|DNA geometric change, ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 0,01135674 0,07593166 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 0,01135674 0,07571157 ! behavioral interaction between organisms GO:0051705 25 17 1,000 0,01135674 0,07549275 ! synaptogenesis GO:0007416 24 17 1,000 0,01135674 0,07527519 ! peptidyl-serine modification GO:0018209 27 17 1,000 0,01135674 0,07505889 ! regulation of angiogenesis GO:0045765 94 49 2,000 0,01162235 0,07659427 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 0,01162235 0,07637543 ! regulation of actin filament length GO:0030832 72 50 2,000 0,01227847 0,08045721 ! positive regulation of growth GO:0045927 67 50 2,000 0,01227847 0,08022864 ! positive regulation of DNA replication GO:0045740 29 18 1,000 0,01269636 0,08272419 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 0,01269636 0,0824905 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 0,01269636 0,08225814 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 0,01269636 0,08202707 ! visual learning GO:0008542 35 18 1,000 0,01269636 0,08179731 ! somitogenesis GO:0001756 24 18 1,000 0,01269636 0,08156882 ! regulation of protein catabolic process GO:0042176 77 51 2,000 0,01295546 0,08300157 ! positive regulation of organelle organization GO:0010638 82 51 2,000 0,01295546 0,08277101 ! regulation of cellular component size GO:0032535 74 52 2,000 0,01365342 0,08698853 ! nucleotide-excision repair GO:0006289 64 52 2,000 0,01365342 0,08674823 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01410131 0,08934716 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 0,01410131 0,0891017 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 0,01410131 0,08885758 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 0,01410131 0,0886148 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 1,000 0,01410131 0,08837335 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 0,01410131 0,0881332 ! protein stabilization GO:0050821 26 19 1,000 0,01410131 0,08789436 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01410131 0,08765681 ! positive regulation of ossification GO:0045778 30 19 1,000 0,01410131 0,08742053 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 0,01410131 0,08718553 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 0,01410131 0,08695179 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01410131 0,0867193 ! apoptotic nuclear changes GO:0030262 24 19 1,000 0,01410131 0,08648805 ! response to lipopolysaccharide GO:0032496 26 19 1,000 0,01410131 0,08625803 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01410131 0,08602923 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 0,01410131 0,08580163 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01437242 0,08722048 ! skeletal system morphogenesis GO:0048705 78 53 2,000 0,01437242 0,08699095 ! regulation of mitosis GO:0007088 84 54 2,000 0,01511254 0,09123056 GO:0051783|regulation of nuclear division, ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01511254 0,09099174 ! extracellular structure organization GO:0043062 156 99 3,000 0,01529032 0,09182175 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01557022 0,0932591 ! regulation of neurotransmitter transport GO:0051588 35 20 1,000 0,01557022 0,09301687 ! spinal cord development GO:0021510 31 20 1,000 0,01557022 0,0927759 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01557022 0,09253616 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 0,01557022 0,09229767 ! chromosome condensation GO:0030261 31 20 1,000 0,01557022 0,0920604 ! pallium development GO:0021543 38 20 1,000 0,01557022 0,09182435 ! positive regulation of locomotion GO:0040017 35 20 1,000 0,01557022 0,0915895 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! neuromuscular process controlling balance GO:0050885 48 20 1,000 0,01557022 0,09135586 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01557022 0,0911234 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 0,01665642 0,09723288 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01710173 0,0995797 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01710173 0,09932823 ! sulfur amino acid metabolic process GO:0000096 24 21 1,000 0,01710173 0,09907804 ! positive regulation of bone remodeling GO:0046852 33 21 1,000 0,01710173 0,0988291 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 0,01710173 0,09858141 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01710173 0,09833495 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01710173 0,09808973 ! visual behavior GO:0007632 39 21 1,000 0,01710173 0,09784572 ! cell aging GO:0007569 32 21 1,000 0,01710173 0,09760293 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01710173 0,09736134 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 0,01710173 0,09712094 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01710173 0,09688173 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01710173 0,09664369 ! negative regulation of cytokine production GO:0001818 31 21 1,000 0,01710173 0,09640682 ! acetyl-CoA catabolic process GO:0046356 31 21 1,000 0,01710173 0,0961711 GO:0006099|tricarboxylic acid cycle, ! camera-type eye development GO:0043010 88 57 2,000 0,01746028 0,09794789 ! developmental maturation GO:0021700 75 57 2,000 0,01746028 0,09770958 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01869453 0,10436269 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01869453 0,10410999 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01869453 0,10385852 ! molting cycle process GO:0022404 40 22 1,000 0,01869453 0,10360826 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01869453 0,1033592 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01869453 0,10311134 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01869453 0,10286466 ! coenzyme catabolic process GO:0009109 33 22 1,000 0,01869453 0,10261916 ! regulation of behavior GO:0050795 38 22 1,000 0,01869453 0,10237483 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01869453 0,10213166 ! aspartate family amino acid metabolic process GO:0009066 24 22 1,000 0,01869453 0,10188964 ! neural tube closure GO:0001843 33 22 1,000 0,01869453 0,10164876 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,02034732 0,11037461 ! myelination GO:0042552 35 23 1,000 0,02034732 0,11011491 ! acetyl-CoA metabolic process GO:0006084 33 23 1,000 0,02034732 0,10985642 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,02034732 0,10959915 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,02034732 0,10934307 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,02034732 0,1090882 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,02034732 0,1088345 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,02034732 0,10858199 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,02034732 0,10833064 ! hydrogen peroxide metabolic process GO:0042743 30 23 1,000 0,02034732 0,10808045 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,02034732 0,10783142 ! group transfer coenzyme metabolic process GO:0006752 28 23 1,000 0,02034732 0,10758353 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,02034732 0,10733678 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 0,02034732 0,10709116 ! urogenital system development GO:0001655 101 61 2,000 0,02088946 0,10969354 ! extracellular matrix organization GO:0030198 103 61 2,000 0,02088946 0,10944367 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 0,02088946 0,10919493 ! negative regulation of cell growth GO:0030308 106 62 2,000 0,02180032 0,11369781 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,0220588 0,11478563 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,0220588 0,11452652 ! primary neural tube formation GO:0014020 35 24 1,000 0,0220588 0,11426858 ! negative regulation of cell development GO:0010721 56 24 1,000 0,0220588 0,11401179 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,0220588 0,11375616 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,0220588 0,11350167 ! negative regulation of cell size GO:0045792 108 64 2,000 0,02368637 0,12160413 ! regulation of actin cytoskeleton organization GO:0032956 97 64 2,000 0,02368637 0,12133329 ! iron ion homeostasis GO:0055072 39 25 1,000 0,02382772 0,12178612 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,02382772 0,12151608 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,02382772 0,12124724 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,02382772 0,12097959 GO:0045840|positive regulation of mitosis, ! reproductive structure development GO:0048608 90 65 2,000 0,02466156 0,1249374 ! B cell activation GO:0042113 104 65 2,000 0,02466156 0,12466281 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,02466156 0,12438943 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 0,02466156 0,12411724 ! positive regulation of T cell activation GO:0050870 94 65 2,000 0,02466156 0,12384625 ! translational initiation GO:0006413 43 26 1,000 0,02565282 0,12854353 ! circadian rhythm GO:0007623 42 26 1,000 0,02565282 0,12826408 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,02565282 0,12798585 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,02565282 0,12770883 ! regulation of actin filament-based process GO:0032970 99 66 2,000 0,02565817 0,1274596 ! response to ionizing radiation GO:0010212 47 27 1,000 0,02753287 0,13647758 ! natural killer cell activation GO:0030101 35 27 1,000 0,02753287 0,13618408 ! cofactor catabolic process GO:0051187 45 27 1,000 0,02753287 0,13589184 ! learning or memory GO:0007611 123 68 2,000 0,0277156 0,13650079 ! response to drug GO:0042493 108 69 2,000 0,02877635 0,14142223 ! mRNA export from nucleus GO:0006406 39 28 1,000 0,02946666 0,14450602 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02946666 0,14419856 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,02946666 0,14389241 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,02946666 0,14358755 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02946666 0,14328398 GO:0008366|axon ensheathment, ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,02946666 0,1429817 ! neural tube formation GO:0001841 41 28 1,000 0,02946666 0,14268068 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,02946666 0,14238093 ! placenta development GO:0001890 37 28 1,000 0,02946666 0,14208244 ! regulation of B cell activation GO:0050864 42 28 1,000 0,02946666 0,1417852 ! regulation of catabolic process GO:0009894 106 70 2,000 0,02985842 0,14337026 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,03096175 0,14835839 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,03145301 0,15039899 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,03145301 0,15008696 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,03145301 0,14977622 ! telencephalon development GO:0021537 52 29 1,000 0,03145301 0,14946676 ! tissue homeostasis GO:0001894 42 29 1,000 0,03145301 0,14915858 GO:0048871|multicellular organismal homeostasis, ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,03208631 0,15184879 ! negative regulation of transport GO:0051051 116 73 2,000 0,03323203 0,15694801 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,03323203 0,15662639 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,03349072 0,15752283 ! spindle organization GO:0007051 37 30 1,000 0,03349072 0,15720135 ! hindbrain development GO:0030902 45 30 1,000 0,03349072 0,15688118 ! adult locomotory behavior GO:0008344 47 30 1,000 0,03349072 0,15656232 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,03349072 0,15624475 ! mammary gland development GO:0030879 57 31 1,000 0,03557865 0,16564961 ! glial cell differentiation GO:0010001 55 31 1,000 0,03557865 0,16531496 ! segmentation GO:0035282 41 31 1,000 0,03557865 0,16498166 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,03557865 0,16464971 ! metanephros development GO:0001656 58 31 1,000 0,03557865 0,16431909 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03557865 0,16398979 ! cell fate specification GO:0001708 37 31 1,000 0,03557865 0,16366181 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,03557865 0,16333514 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,03557865 0,16300977 ! negative regulation of growth GO:0045926 123 75 2,000 0,03558675 0,16272271 ! regulation of ligase activity GO:0051340 114 75 2,000 0,03558675 0,16239985 ! amine biosynthetic process GO:0009309 97 76 2,000 0,03679561 0,16758395 ! regulation of muscle development GO:0048634 48 32 1,000 0,03771566 0,17143482 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,03771566 0,17109669 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03771566 0,17075988 ! regulation of protein stability GO:0031647 48 32 1,000 0,03771566 0,1704244 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,03771566 0,17009024 ! sex differentiation GO:0007548 105 77 2,000 0,03802536 0,17115135 ! RNA export from nucleus GO:0006405 44 33 1,000 0,03990062 0,17924106 ! nucleus organization GO:0006997 49 33 1,000 0,03990062 0,17889166 ! female gonad development GO:0008585 49 33 1,000 0,03990062 0,17854362 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03990062 0,17819694 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,03990062 0,17785159 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,03990062 0,17750759 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,04183925 0,18577275 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 2,000 0,04183925 0,18541481 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,04213242 0,18635493 ! feeding behavior GO:0007631 45 34 1,000 0,04213242 0,18599725 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,04213242 0,18564093 ! neuron migration GO:0001764 46 34 1,000 0,04213242 0,18528598 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,04213242 0,18493238 ! female gamete generation GO:0007292 43 34 1,000 0,04213242 0,18458013 ! aerobic respiration GO:0009060 47 34 1,000 0,04213242 0,18422921 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,04213242 0,18387963 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,04213242 0,18353137 ! mRNA transport GO:0051028 121 81 2,000 0,0431518 0,18761651 ! regulation of neurological system process GO:0031644 122 81 2,000 0,0431518 0,18726252 ! Notch signaling pathway GO:0007219 56 35 1,000 0,04440997 0,19235959 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,04440997 0,19199801 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,04440997 0,19163779 ! glycogen metabolic process GO:0005977 48 35 1,000 0,04440997 0,19127892 ! protein homooligomerization GO:0051260 52 35 1,000 0,04440997 0,19092139 ! biogenic amine metabolic process GO:0006576 121 83 2,000 0,04583819 0,19669372 ! regulation of cell adhesion GO:0030155 159 83 2,000 0,04583819 0,19632744 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04673221 0,19978454 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,04673221 0,19941388 ! neural tube development GO:0021915 50 36 1,000 0,04673221 0,1990446 ! heterocycle biosynthetic process GO:0018130 46 36 1,000 0,04673221 0,19867668 ! tissue remodeling GO:0048771 62 36 1,000 0,04673221 0,19831011 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04673221 0,1979449 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,04673221 0,19758103 GO:0006073|cellular glucan metabolic process, ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04714005 0,19893964 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04714005 0,19857528 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04714005 0,19821226 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04714005 0,19785055 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04714005 0,19749017 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04714005 0,1971311 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04714005 0,19677333 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04714005 0,19641686 ! sleep GO:0030431 11 5 0,000 0,04714005 0,19606167 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04714005 0,19570777 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04714005 0,19535514 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04714005 0,19500378 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04714005 0,19465369 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04714005 0,19430485 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04714005 0,19395725 ! tongue development GO:0043586 6 5 0,000 0,04714005 0,1936109 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04714005 0,19326578 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04714005 0,19292189 ! cobalt ion transport GO:0006824 9 5 0,000 0,04714005 0,19257923 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04714005 0,19223777 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04714005 0,19189753 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04714005 0,19155849 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04714005 0,19122064 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04714005 0,19088399 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04714005 0,19054851 ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04714005 0,19021422 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04714005 0,18988109 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04714005 0,18954913 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04714005 0,18921833 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04714005 0,18888868 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,04714005 0,18856018 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04714005 0,18823282 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04714005 0,18790659 ! malate metabolic process GO:0006108 7 5 0,000 0,04714005 0,18758149 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04714005 0,18725752 ! behavioral response to pain GO:0048266 7 5 0,000 0,04714005 0,18693466 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04714005 0,18661292 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04714005 0,18629228 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04714005 0,18597273 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04714005 0,18565429 ! mating behavior GO:0007617 6 5 0,000 0,04714005 0,18533693 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04714005 0,18502066 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04714005 0,18470546 ! rhythmic behavior GO:0007622 12 5 0,000 0,04714005 0,18439133 ! copulation GO:0007620 7 5 0,000 0,04714005 0,18407828 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04714005 0,18376628 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04714005 0,18345534 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04714005 0,18314545 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04714005 0,1828366 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04714005 0,18252879 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04714005 0,18222202 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04714005 0,18191628 ! response to protozoan GO:0001562 9 5 0,000 0,04714005 0,18161156 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,04714005 0,18130787 ! lymph vessel development GO:0001945 7 5 0,000 0,04714005 0,18100518 ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04714005 0,18070351 ! parathyroid gland development GO:0060017 8 5 0,000 0,04714005 0,18040284 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04714005 0,18010316 ! anagen GO:0042640 6 5 0,000 0,04714005 0,17980448 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04714005 0,17950679 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04714005 0,17921009 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04714005 0,17891436 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04714005 0,17861961 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04714005 0,17832583 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04714005 0,17803301 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04714005 0,17774115 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04714005 0,17745025 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,04714005 0,1771603 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04714005 0,1768713 ! ovulation GO:0030728 6 5 0,000 0,04714005 0,17658323 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04714005 0,1762961 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,04714005 0,17600991 ! response to pH GO:0009268 9 5 0,000 0,04714005 0,17572464 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04714005 0,1754403 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04714005 0,17515687 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04714005 0,17487436 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04714005 0,17459276 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04714005 0,17431206 ! polyol catabolic process GO:0046174 7 5 0,000 0,04714005 0,17403227 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04714005 0,17375337 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04714005 0,17347537 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04714005 0,17319825 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04714005 0,17292202 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04714005 0,17264666 ! urea metabolic process GO:0019627 6 5 0,000 0,04714005 0,17237218 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04714005 0,17209858 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04714005 0,17182584 ! neutrophil activation GO:0042119 5 5 0,000 0,04714005 0,17155396 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04714005 0,17128294 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04714005 0,17101278 ! response to food GO:0032094 5 5 0,000 0,04714005 0,17074347 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04714005 0,17047501 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04714005 0,17020738 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04714005 0,1699406 ! forebrain neuron development GO:0021884 7 5 0,000 0,04714005 0,16967465 ! melanosome organization GO:0032438 7 5 0,000 0,04714005 0,16940954 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04714005 0,16914525 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04714005 0,16888178 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04714005 0,16861914 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04714005 0,1683573 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,04714005 0,16809629 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04714005 0,16783607 ! nucleoside transport GO:0015858 6 5 0,000 0,04714005 0,16757667 ! nucleoside salvage GO:0043174 7 5 0,000 0,04714005 0,16731806 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04714005 0,16706025 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04714005 0,16680324 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04714005 0,16654701 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04714005 0,16629157 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04714005 0,16603691 ! depyrimidination GO:0045008 8 5 0,000 0,04714005 0,16578303 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04714005 0,16552993 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04714005 0,1652776 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04714005 0,16502603 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04714005 0,16477523 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04714005 0,1645252 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04714005 0,16427592 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,04714005 0,16402739 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04714005 0,16377961 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04714005 0,16353259 GO:0046676|negative regulation of insulin secretion, ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04714005 0,1632863 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04714005 0,16304076 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04714005 0,16279595 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04714005 0,16255188 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04714005 0,16230854 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04714005 0,16206593 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04714005 0,16182404 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04714005 0,16158287 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04714005 0,16134242 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04714005 0,16110268 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04714005 0,16086366 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04714005 0,16062534 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04714005 0,16038773 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04714005 0,16015082 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04714005 0,15991461 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04714005 0,15967909 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04714005 0,15944427 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04714005 0,15921014 ! neural tube patterning GO:0021532 6 5 0,000 0,04714005 0,15897669 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04714005 0,15874393 ! histone demethylation GO:0016577 9 5 0,000 0,04714005 0,15851185 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04714005 0,15828044 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04714005 0,15804971 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,04714005 0,15781966 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04714005 0,15759027 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04714005 0,15736154 ! transcription termination GO:0006353 8 5 0,000 0,04714005 0,15713348 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04714005 0,15690608 ! plasminogen activation GO:0031639 5 5 0,000 0,04714005 0,15667934 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04714005 0,15645325 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04714005 0,15622782 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04714005 0,15600303 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04714005 0,15577889 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,04714005 0,15555539 ! apical protein localization GO:0045176 6 5 0,000 0,04714005 0,15533253 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04714005 0,15511031 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04714005 0,15488872 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04714005 0,15466777 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04714005 0,15444744 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04714005 0,15422774 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04714005 0,15400867 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04714005 0,15379022 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04714005 0,15357239 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,04714005 0,15335517 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04714005 0,15313857 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04714005 0,15292257 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04714005 0,15270719 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04714005 0,15249241 ! neural plate development GO:0001840 6 5 0,000 0,04714005 0,15227824 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04714005 0,15206466 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04714005 0,15185169 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04714005 0,15163931 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,04714005 0,15142752 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04714005 0,15121632 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04714005 0,15100572 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04714005 0,15079569 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04714005 0,15058626 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04714005 0,1503774 ! spindle assembly GO:0051225 5 5 0,000 0,04714005 0,15016912 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04714005 0,14996142 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04714005 0,14975429 ! organ regeneration GO:0031100 7 5 0,000 0,04714005 0,14954773 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04714005 0,14934174 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04714005 0,14913632 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04714005 0,14893146 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04714005 0,14872717 GO:0055081|anion homeostasis, ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,04721183 0,14874962 ! Golgi vesicle transport GO:0048193 138 85 2,000 0,04860564 0,15293156 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,04860564 0,15272264 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,04909807 0,15405942 ! learning GO:0007612 67 37 1,000 0,04909807 0,15384953 ! female pregnancy GO:0007565 130 87 2,000 0,05145328 0,16101025 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,05145328 0,16079149 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,0515065 0,16073943 ! mesenchymal cell development GO:0014031 64 38 1,000 0,0515065 0,16052162 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,0515065 0,16030441 ! pigmentation GO:0043473 74 38 1,000 0,0515065 0,16008778 ! establishment of RNA localization GO:0051236 128 88 2,000 0,05290688 0,16421838 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,05395649 0,16725059 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,05395649 0,16702549 ! chromatin remodeling GO:0006338 68 39 1,000 0,05395649 0,16680099 ! JNK cascade GO:0007254 54 39 1,000 0,05395649 0,1665771 ! developmental growth GO:0048589 62 39 1,000 0,05395649 0,1663538 ! synapse organization GO:0050808 55 39 1,000 0,05395649 0,16613111 ! reproductive developmental process GO:0003006 127 89 2,000 0,05438017 0,16721176 ! regulation of T cell activation GO:0050863 128 89 2,000 0,05438017 0,16698852 ! tRNA transcription GO:0009304 11 6 0,000 0,05629954 0,17265192 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05629954 0,17242202 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05629954 0,17219274 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05629954 0,17196406 ! regulation of helicase activity GO:0051095 11 6 0,000 0,05629954 0,17173599 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05629954 0,17150853 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05629954 0,17128167 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05629954 0,1710554 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05629954 0,17082974 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05629954 0,17060466 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05629954 0,17038018 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05629954 0,17015629 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05629954 0,16993299 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05629954 0,16971027 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05629954 0,16948814 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05629954 0,16926659 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05629954 0,16904561 ! neuron adhesion GO:0007158 9 6 0,000 0,05629954 0,16882521 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05629954 0,16860539 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05629954 0,16838614 ! signal peptide processing GO:0006465 8 6 0,000 0,05629954 0,16816745 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05629954 0,16794934 ! mRNA stabilization GO:0048255 15 6 0,000 0,05629954 0,16773179 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05629954 0,1675148 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05629954 0,16729837 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05629954 0,1670825 ! opsonization GO:0008228 8 6 0,000 0,05629954 0,16686719 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05629954 0,16665243 GO:0042069|regulation of catecholamine metabolic process, ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05629954 0,16643823 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05629954 0,16622457 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05629954 0,16601146 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05629954 0,1657989 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05629954 0,16558688 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05629954 0,1653754 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05629954 0,16516446 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05629954 0,16495406 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05629954 0,1647442 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05629954 0,16453487 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05629954 0,16432607 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05629954 0,16411779 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05629954 0,16391005 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05629954 0,16370283 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05629954 0,16349614 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05629954 0,16328996 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05629954 0,16308431 ! thymic T cell selection GO:0045061 12 6 0,000 0,05629954 0,16287917 ! protein lipoylation GO:0009249 10 6 0,000 0,05629954 0,16267455 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05629954 0,16247044 ! pigment granule organization GO:0048753 11 6 0,000 0,05629954 0,16226684 ! drug transport GO:0015893 6 6 0,000 0,05629954 0,16206375 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05629954 0,16186117 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,05629954 0,1616591 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05629954 0,16145753 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05629954 0,16125646 ! glutamate catabolic process GO:0006538 10 6 0,000 0,05629954 0,1610559 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05629954 0,16085583 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05629954 0,16065625 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05629954 0,16045717 ! adenohypophysis development GO:0021984 10 6 0,000 0,05629954 0,16025859 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05629954 0,16006049 ! hyperosmotic response GO:0006972 8 6 0,000 0,05629954 0,15986289 ! microtubule nucleation GO:0007020 10 6 0,000 0,05629954 0,15966577 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05629954 0,15946914 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05629954 0,15927299 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05629954 0,15907732 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05629954 0,15888213 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05629954 0,15868743 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,05629954 0,15849319 ! response to dietary excess GO:0002021 7 6 0,000 0,05629954 0,15829944 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05629954 0,15810615 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,05629954 0,15791334 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05629954 0,157721 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05629954 0,15752912 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05629954 0,15733772 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05629954 0,15714677 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05629954 0,15695629 ! neuron apoptosis GO:0051402 8 6 0,000 0,05629954 0,15676627 ! organic alcohol transport GO:0015850 9 6 0,000 0,05629954 0,15657671 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,05629954 0,15638761 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05629954 0,15619896 ! male sex determination GO:0030238 9 6 0,000 0,05629954 0,15601077 ! carnitine transport GO:0015879 8 6 0,000 0,05629954 0,15582303 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05629954 0,15563574 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05629954 0,15544891 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05629954 0,15526252 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05629954 0,15507657 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05629954 0,15489108 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05629954 0,15470602 ! parturition GO:0007567 12 6 0,000 0,05629954 0,15452141 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05629954 0,15433723 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05629954 0,1541535 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05629954 0,1539702 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05629954 0,15378734 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05629954 0,15360491 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05629954 0,15342291 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05629954 0,15324135 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05629954 0,15306021 ! interaction with symbiont GO:0051702 8 6 0,000 0,05629954 0,1528795 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05629954 0,15269922 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05629954 0,15251936 ! eating behavior GO:0042755 6 6 0,000 0,05629954 0,15233993 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05629954 0,15216092 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05629954 0,15198232 ! response to copper ion GO:0046688 9 6 0,000 0,05629954 0,15180415 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05629954 0,15162639 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05629954 0,15144905 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05629954 0,15127213 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05629954 0,15109561 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05629954 0,15091951 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05629954 0,15074382 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05629954 0,15056853 ! gas homeostasis GO:0033483 11 6 0,000 0,05629954 0,15039366 ! hair follicle maturation GO:0048820 7 6 0,000 0,05629954 0,15021919 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05629954 0,15004512 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05629954 0,14987146 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05629954 0,1496982 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05629954 0,14952533 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05629954 0,14935287 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05629954 0,14918081 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05629954 0,14900914 ! histone ubiquitination GO:0016574 7 6 0,000 0,05629954 0,14883786 ! regulation of meiosis GO:0040020 10 6 0,000 0,05629954 0,14866698 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05629954 0,14849649 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05629954 0,14832639 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05629954 0,14815668 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05629954 0,14798736 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05629954 0,14781842 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05629954 0,14764987 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05629954 0,14748171 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05629954 0,14731392 ! receptor internalization GO:0031623 9 6 0,000 0,05629954 0,14714652 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05629954 0,1469795 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05629954 0,14681286 ! protein deubiquitination GO:0016579 8 6 0,000 0,05629954 0,14664659 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05629954 0,1464807 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05629954 0,14631519 ! axonal fasciculation GO:0007413 9 6 0,000 0,05629954 0,14615004 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05629954 0,14598528 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05629954 0,14582088 ! midbrain development GO:0030901 6 6 0,000 0,05629954 0,14565685 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05629954 0,14549319 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05629954 0,1453299 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05629954 0,14516697 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05629954 0,14500441 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05629954 0,14484221 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05629954 0,14468038 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05629954 0,14451891 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05629954 0,14435779 ! adult feeding behavior GO:0008343 6 6 0,000 0,05629954 0,14419704 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05629954 0,14403664 ! pigment granule transport GO:0051904 12 6 0,000 0,05629954 0,1438766 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05629954 0,14371691 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05629954 0,14355758 ! catecholamine transport GO:0051937 7 6 0,000 0,05629954 0,1433986 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05629954 0,14323998 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05629954 0,1430817 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05629954 0,14292377 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,05629954 0,1427662 ! protein prenylation GO:0018342 10 6 0,000 0,05629954 0,14260896 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05629954 0,14245208 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,05629954 0,14229554 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05629954 0,14213934 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05629954 0,14198349 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05629954 0,14182797 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,05644703 0,14204395 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,05644703 0,14188871 ! response to calcium ion GO:0051592 58 40 1,000 0,05644703 0,14173381 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,05644703 0,14157924 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,05644703 0,14142502 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,05644703 0,14127113 ! RNA localization GO:0006403 135 91 2,000 0,05738535 0,14346338 ! DNA recombination GO:0006310 146 92 2,000 0,05891698 0,14713252 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,05897711 0,14712295 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,05897711 0,14696356 ! endosome transport GO:0016197 71 41 1,000 0,05897711 0,1468045 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,05897711 0,1466458 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,05897711 0,14648743 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,06046778 0,15002794 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 0,06046778 0,14986627 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,06154577 0,1523738 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,06154577 0,15220996 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,06154577 0,15204647 ! positive regulation of binding GO:0051099 59 43 1,000 0,06415203 0,15831508 ! leukocyte migration GO:0050900 60 43 1,000 0,06415203 0,1581454 ! vesicle organization GO:0016050 79 43 1,000 0,06415203 0,15797608 ! response to insulin stimulus GO:0032868 63 43 1,000 0,06415203 0,15780712 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,06415203 0,15763852 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 2,000 0,06523391 0,16012594 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06537151 0,1602926 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06537151 0,1601219 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06537151 0,15995155 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06537151 0,15978157 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06537151 0,15961195 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06537151 0,1594427 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06537151 0,15927379 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06537151 0,15910525 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06537151 0,15893706 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06537151 0,15876923 ! reproductive behavior GO:0019098 12 7 0,000 0,06537151 0,15860175 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06537151 0,15843463 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06537151 0,15826785 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,06537151 0,15810143 ! oligopeptide transport GO:0006857 11 7 0,000 0,06537151 0,15793536 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06537151 0,15776963 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06537151 0,15760426 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06537151 0,15743923 ! RNA methylation GO:0001510 11 7 0,000 0,06537151 0,15727454 ! pericardium development GO:0060039 8 7 0,000 0,06537151 0,1571102 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06537151 0,1569462 ! fibril organization GO:0043206 13 7 0,000 0,06537151 0,15678255 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,06537151 0,15661923 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06537151 0,15645626 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,06537151 0,15629362 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06537151 0,15613132 ! lipoprotein transport GO:0042953 9 7 0,000 0,06537151 0,15596936 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06537151 0,15580773 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06537151 0,15564644 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06537151 0,15548548 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06537151 0,15532486 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06537151 0,15516456 ! chemosensory behavior GO:0007635 9 7 0,000 0,06537151 0,1550046 ! microtubule bundle formation GO:0001578 8 7 0,000 0,06537151 0,15484497 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,06537151 0,15468566 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06537151 0,15452668 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06537151 0,15436803 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06537151 0,1542097 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06537151 0,1540517 ! reflex GO:0060004 12 7 0,000 0,06537151 0,15389402 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06537151 0,15373667 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06537151 0,15357963 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06537151 0,15342292 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06537151 0,15326653 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06537151 0,15311045 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06537151 0,15295469 ! spinal cord patterning GO:0021511 7 7 0,000 0,06537151 0,15279925 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06537151 0,15264412 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06537151 0,15248931 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06537151 0,15233481 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06537151 0,15218063 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06537151 0,15202676 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06537151 0,15187319 ! endosome organization GO:0007032 10 7 0,000 0,06537151 0,15171994 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06537151 0,151567 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06537151 0,15141436 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06537151 0,15126203 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,06537151 0,15111001 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06537151 0,15095829 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06537151 0,15080688 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06537151 0,15065577 ! galactose metabolic process GO:0006012 10 7 0,000 0,06537151 0,15050497 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06537151 0,15035446 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06537151 0,15020426 ! organ growth GO:0035265 11 7 0,000 0,06537151 0,15005435 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06537151 0,14990475 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06537151 0,14975544 ! retinol metabolic process GO:0042572 9 7 0,000 0,06537151 0,14960643 ! behavioral fear response GO:0001662 13 7 0,000 0,06537151 0,14945772 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06537151 0,1493093 ! rRNA modification GO:0000154 12 7 0,000 0,06537151 0,14916117 ! protein heterooligomerization GO:0051291 10 7 0,000 0,06537151 0,14901334 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06537151 0,1488658 ! response to UV-B GO:0010224 11 7 0,000 0,06537151 0,14871856 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,06537151 0,1485716 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06537151 0,14842494 ! intermediate filament organization GO:0045109 11 7 0,000 0,06537151 0,14827856 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06537151 0,14813247 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06537151 0,14798667 ! fibrinolysis GO:0042730 9 7 0,000 0,06537151 0,14784116 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,06537151 0,14769593 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06537151 0,14755099 ! B cell lineage commitment GO:0002326 17 7 0,000 0,06537151 0,14740633 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06537151 0,14726196 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06537151 0,14711787 ! response to tropane GO:0014073 13 7 0,000 0,06537151 0,14697406 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06537151 0,14683053 ! melanosome localization GO:0032400 10 7 0,000 0,06537151 0,14668728 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06537151 0,14654431 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06537151 0,14640162 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06537151 0,1462592 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06537151 0,14611707 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06537151 0,14597521 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06537151 0,14583362 ! mast cell activation GO:0045576 9 7 0,000 0,06537151 0,14569231 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06537151 0,14555127 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,06537151 0,1454105 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06537151 0,14527001 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06537151 0,14512979 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,06537151 0,14498984 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06537151 0,14485016 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06537151 0,14471074 ! T cell lineage commitment GO:0002360 12 7 0,000 0,06537151 0,1445716 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06537151 0,14443272 GO:0002714|positive regulation of B cell mediated immunity, ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06537151 0,14429411 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06537151 0,14415576 ! response to tumor cell GO:0002347 12 7 0,000 0,06537151 0,14401768 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06537151 0,14387987 ! neuroblast proliferation GO:0007405 13 7 0,000 0,06537151 0,14374232 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06537151 0,14360503 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06537151 0,143468 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,06537151 0,14333123 ! diuresis GO:0030146 12 7 0,000 0,06537151 0,14319473 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06537151 0,14305848 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06537151 0,14292249 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06537151 0,14278676 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06537151 0,14265129 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06537151 0,14251608 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06537151 0,14238112 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06537151 0,14224642 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,06537151 0,14211197 ! lymph node development GO:0048535 9 7 0,000 0,06537151 0,14197777 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06537151 0,14184383 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06537151 0,14171014 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06537151 0,14157671 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06537151 0,14144352 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06537151 0,14131058 ! ATP catabolic process GO:0006200 10 7 0,000 0,06537151 0,1411779 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06537151 0,14104546 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06537151 0,14091327 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06537151 0,14078133 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06537151 0,14064964 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06537151 0,14051819 ! muscle adaptation GO:0043500 12 7 0,000 0,06537151 0,14038699 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06537151 0,14025603 GO:0006043|glucosamine catabolic process, ! retina homeostasis GO:0001895 9 7 0,000 0,06537151 0,14012531 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06537151 0,13999484 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06537151 0,13986462 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06537151 0,13973463 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06537151 0,13960489 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06537151 0,13947538 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06537151 0,13934612 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06537151 0,13921709 ! glycolysis GO:0006096 53 44 1,000 0,06679494 0,14211689 ! regulation of action potential GO:0001508 71 44 1,000 0,06679494 0,14198554 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,06679494 0,14185444 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,06679494 0,14172358 ! Ras protein signal transduction GO:0007265 162 100 2,000 0,07184876 0,15230612 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,072187 0,15288222 ! regulation of ossification GO:0030278 71 46 1,000 0,072187 0,15274158 ! histone modification GO:0016570 68 46 1,000 0,072187 0,15260119 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,07435677 0,15704369 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,07435677 0,15689962 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,07435677 0,1567558 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,07435677 0,15661225 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,07435677 0,15646897 ! associative learning GO:0008306 15 8 0,000 0,07435677 0,15632594 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,07435677 0,15618318 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,07435677 0,15604068 ! phosphate transport GO:0006817 10 8 0,000 0,07435677 0,15589843 ! N-glycan processing GO:0006491 12 8 0,000 0,07435677 0,15575645 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,07435677 0,15561472 ! UTP metabolic process GO:0046051 8 8 0,000 0,07435677 0,15547326 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,07435677 0,15533205 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,07435677 0,15519109 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,07435677 0,15505039 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,07435677 0,15490995 ! succinate metabolic process GO:0006105 14 8 0,000 0,07435677 0,15476976 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,07435677 0,15462982 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,07435677 0,15449014 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,07435677 0,15435071 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,07435677 0,15421153 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,07435677 0,1540726 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,07435677 0,15393392 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,07435677 0,15379549 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,07435677 0,15365731 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,07435677 0,15351937 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,07435677 0,15338169 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,07435677 0,15324425 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,07435677 0,15310706 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,07435677 0,15297011 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,07435677 0,15283341 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,07435677 0,15269695 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,07435677 0,15256073 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,07435677 0,15242476 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,07435677 0,15228903 ! melanin metabolic process GO:0006582 12 8 0,000 0,07435677 0,15215354 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,07435677 0,15201829 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,07435677 0,15188329 ! macrophage activation GO:0042116 12 8 0,000 0,07435677 0,15174852 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,07435677 0,15161399 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,07435677 0,1514797 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,07435677 0,15134565 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,07435677 0,15121183 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,07435677 0,15107825 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,07435677 0,15094491 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,07435677 0,1508118 ! ruffle organization GO:0031529 11 8 0,000 0,07435677 0,15067893 ! osteoblast development GO:0002076 13 8 0,000 0,07435677 0,15054629 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,07435677 0,15041388 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,07435677 0,15028171 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,07435677 0,15014976 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,07435677 0,15001805 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,07435677 0,14988657 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,07435677 0,14975533 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,07435677 0,14962431 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,07435677 0,14949352 ! oligodendrocyte development GO:0014003 8 8 0,000 0,07435677 0,14936295 ! segment specification GO:0007379 10 8 0,000 0,07435677 0,14923262 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,07435677 0,14910251 ! cellular extravasation GO:0045123 11 8 0,000 0,07435677 0,14897263 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,07435677 0,14884298 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,07435677 0,14871355 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,07435677 0,14858435 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,07435677 0,14845537 ! snRNA metabolic process GO:0016073 10 8 0,000 0,07435677 0,14832661 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,07435677 0,14819808 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,07435677 0,14806977 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,07435677 0,14794168 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,07435677 0,14781381 ! nucleosome disassembly GO:0006337 12 8 0,000 0,07435677 0,14768617 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,07435677 0,14755874 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,07435677 0,14743154 ! icosanoid secretion GO:0032309 12 8 0,000 0,07435677 0,14730455 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,07435677 0,14717778 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,07435677 0,14705123 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,07435677 0,1469249 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,07435677 0,14679878 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,07435677 0,14667288 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,07435677 0,1465472 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,07435677 0,14642173 ! sterol catabolic process GO:0016127 9 8 0,000 0,07435677 0,14629648 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,07435677 0,14617144 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,07435677 0,14604661 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,07435677 0,145922 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,07435677 0,1457976 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,07435677 0,14567341 ! prophase GO:0051324 11 8 0,000 0,07435677 0,14554943 ! S phase GO:0051320 8 8 0,000 0,07435677 0,14542566 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,07435677 0,14530211 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,07435677 0,14517876 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,07435677 0,14505562 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,07435677 0,1449327 ! hormone catabolic process GO:0042447 13 8 0,000 0,07435677 0,14480998 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,07435677 0,14468746 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,07435677 0,14456516 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,07435677 0,14444306 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,07435677 0,14432117 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,07435677 0,14419948 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,07435677 0,144078 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,07435677 0,14395672 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,07435677 0,14383564 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,07435677 0,14371477 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,07435677 0,14359411 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,07435677 0,14347364 ! regulation of embryonic development GO:0045995 16 8 0,000 0,07435677 0,14335338 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,07435677 0,14323332 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,07435677 0,14311346 ! covalent chromatin modification GO:0016569 75 47 1,000 0,07493432 0,14410446 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,07493432 0,14398407 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,07493432 0,14386388 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,07493432 0,1437439 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,07493432 0,14362411 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,07771464 0,14882903 ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,07771464 0,14870521 ! nuclear export GO:0051168 69 48 1,000 0,07771464 0,1485816 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,07771464 0,14845819 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,07771464 0,14833499 ! sulfur compound biosynthetic process GO:0044272 62 49 1,000 0,08052707 0,15357568 ! RNA elongation GO:0006354 62 49 1,000 0,08052707 0,15344844 ! germ cell development GO:0007281 68 49 1,000 0,08052707 0,15332142 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,08052707 0,1531946 ! cartilage development GO:0051216 70 49 1,000 0,08052707 0,15306799 ! regulation of developmental growth GO:0048638 13 9 0,000 0,08325617 0,15812485 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,08325617 0,15799439 ! telencephalon cell migration GO:0022029 16 9 0,000 0,08325617 0,15786413 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08325617 0,1577341 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08325617 0,15760428 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08325617 0,15747467 ! CTP metabolic process GO:0046036 9 9 0,000 0,08325617 0,15734527 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 9 9 0,000 0,08325617 0,15721609 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08325617 0,15708712 ! social behavior GO:0035176 14 9 0,000 0,08325617 0,15695836 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,08325617 0,15682981 ! regulation of histone modification GO:0031056 11 9 0,000 0,08325617 0,15670147 ! regulation of glycolysis GO:0006110 15 9 0,000 0,08325617 0,15657334 ! response to pain GO:0048265 16 9 0,000 0,08325617 0,15644542 ! protein complex disassembly GO:0043241 17 9 0,000 0,08325617 0,15631771 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08325617 0,15619021 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,08325617 0,15606291 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,08325617 0,15593583 ! lung alveolus development GO:0048286 17 9 0,000 0,08325617 0,15580895 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08325617 0,15568227 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08325617 0,1555558 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08325617 0,15542954 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08325617 0,15530348 ! protein targeting to ER GO:0045047 19 9 0,000 0,08325617 0,15517763 ! T cell selection GO:0045058 18 9 0,000 0,08325617 0,15505198 ! endoderm development GO:0007492 12 9 0,000 0,08325617 0,15492653 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08325617 0,15480129 GO:0006688|glycosphingolipid biosynthetic process, ! arginine catabolic process GO:0006527 10 9 0,000 0,08325617 0,15467625 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08325617 0,15455141 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,08325617 0,15442677 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,08325617 0,15430233 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,08325617 0,1541781 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,08325617 0,15405406 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08325617 0,15393022 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08325617 0,15380658 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08325617 0,15368314 ! mannose metabolic process GO:0006013 9 9 0,000 0,08325617 0,1535599 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,08325617 0,15343685 ! receptor clustering GO:0043113 15 9 0,000 0,08325617 0,15331401 ! epithelial cell development GO:0002064 10 9 0,000 0,08325617 0,15319136 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08325617 0,1530689 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08325617 0,15294664 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08325617 0,15282458 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08325617 0,15270271 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08325617 0,15258103 ! motor axon guidance GO:0008045 14 9 0,000 0,08325617 0,15245955 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08325617 0,15233826 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,08325617 0,15221717 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,08325617 0,15209626 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,08325617 0,15197555 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08325617 0,15185503 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08325617 0,1517347 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,08325617 0,15161456 ! response to amine stimulus GO:0014075 13 9 0,000 0,08325617 0,15149462 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08325617 0,15137486 ! renal water homeostasis GO:0003091 14 9 0,000 0,08325617 0,15125529 ! postreplication repair GO:0006301 11 9 0,000 0,08325617 0,15113591 ! mRNA cleavage GO:0006379 13 9 0,000 0,08325617 0,15101672 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08325617 0,15089771 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,08325617 0,15077889 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08325617 0,15066026 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,08325617 0,15054182 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,08325617 0,15042356 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08325617 0,15030549 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,08325617 0,1501876 ! acid secretion GO:0046717 14 9 0,000 0,08325617 0,1500699 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08325617 0,14995238 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08325617 0,14983505 ! purine base metabolic process GO:0006144 18 9 0,000 0,08325617 0,1497179 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08325617 0,14960093 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08325617 0,14948415 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08325617 0,14936755 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,08325617 0,14925113 ! detection of calcium ion GO:0005513 13 9 0,000 0,08325617 0,14913489 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08325617 0,14901883 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08325617 0,14890295 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08325617 0,14878725 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08325617 0,14867173 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08325617 0,1485564 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08325617 0,14844124 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08325617 0,14832625 ! prepulse inhibition GO:0060134 14 9 0,000 0,08325617 0,14821145 ! insulin secretion GO:0030073 17 9 0,000 0,08325617 0,14809682 ! sequestering of metal ion GO:0051238 11 9 0,000 0,08325617 0,14798238 ! response to nicotine GO:0035094 16 9 0,000 0,08325617 0,1478681 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08325617 0,14775401 ! regulation of synapse organization GO:0050807 12 9 0,000 0,08325617 0,14764009 ! membrane fusion GO:0006944 80 50 1,000 0,08337077 0,1477294 ! lipid modification GO:0030258 73 50 1,000 0,08337077 0,14761568 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,08337077 0,14750213 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,08624486 0,15246978 GO:0010863|positive regulation of phospholipase C activity, ! adult behavior GO:0030534 80 51 1,000 0,08624486 0,15235267 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,08624486 0,15223575 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,08914852 0,15724048 ! aging GO:0007568 79 52 1,000 0,08914852 0,15711999 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09207051 0,16214562 ! neuron fate specification GO:0048665 11 10 0,000 0,09207051 0,16202156 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09207051 0,16189769 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,09207051 0,16177401 ! synapsis GO:0007129 13 10 0,000 0,09207051 0,16165052 GO:0070192|chromosome organization involved in meiosis, ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,09207051 0,16152721 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09207051 0,1614041 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,09207051 0,16128117 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09207051 0,16115843 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,09207051 0,16103588 ! phospholipid efflux GO:0033700 16 10 0,000 0,09207051 0,16091351 ! hippocampus development GO:0021766 19 10 0,000 0,09207051 0,16079133 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,09207051 0,16066933 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09207051 0,16054752 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,09207051 0,16042589 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,09207051 0,16030445 ! pathogenesis GO:0009405 13 10 0,000 0,09207051 0,16018319 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09207051 0,16006211 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09207051 0,15994122 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09207051 0,15982051 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,09207051 0,15969998 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09207051 0,15957964 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09207051 0,15945947 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,09207051 0,15933949 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09207051 0,15921968 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09207051 0,15910006 ! B cell proliferation GO:0042100 14 10 0,000 0,09207051 0,15898061 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,09207051 0,15886135 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09207051 0,15874226 ! forebrain cell migration GO:0021885 17 10 0,000 0,09207051 0,15862335 ! lipid digestion GO:0044241 15 10 0,000 0,09207051 0,15850462 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09207051 0,15838607 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09207051 0,1582677 ! UV protection GO:0009650 14 10 0,000 0,09207051 0,1581495 ! entry into host cell GO:0030260 20 10 0,000 0,09207051 0,15803148 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,09207051 0,15791363 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09207051 0,15779596 ! negative regulation of ossification GO:0030279 19 10 0,000 0,09207051 0,15767846 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,09207051 0,15756114 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,09207051 0,157444 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09207051 0,15732703 ! regulation of organ growth GO:0046620 11 10 0,000 0,09207051 0,15721023 ! response to dsRNA GO:0043331 18 10 0,000 0,09207051 0,1570936 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09207051 0,15697715 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09207051 0,15686087 ! embryonic axis specification GO:0000578 12 10 0,000 0,09207051 0,15674476 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,09207051 0,15662883 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09207051 0,15651306 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09207051 0,15639747 ! cranial nerve development GO:0021545 12 10 0,000 0,09207051 0,15628205 ! fucose catabolic process GO:0019317 16 10 0,000 0,09207051 0,1561668 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,09207051 0,15605171 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,09207051 0,1559368 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09207051 0,15582206 ! zymogen activation GO:0031638 14 10 0,000 0,09207051 0,15570748 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09207051 0,15559308 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09207051 0,15547884 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09207051 0,15536477 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09207051 0,15525086 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09207051 0,15513713 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09207051 0,15502356 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09207051 0,15491015 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,09207051 0,15479691 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09207051 0,15468384 ! detection of bacterium GO:0016045 10 10 0,000 0,09207051 0,15457093 ! embryonic gut development GO:0048566 11 10 0,000 0,09207051 0,15445819 ! activation of innate immune response GO:0002218 10 10 0,000 0,09207051 0,15434561 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09207051 0,15423319 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,09207051 0,15412094 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,09207051 0,15400886 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,09207051 0,15389693 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,09207051 0,15378517 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,09207051 0,15367357 ! kidney development GO:0001822 90 53 1,000 0,09208091 0,15357948 ! single fertilization GO:0007338 59 53 1,000 0,09208091 0,15346819 ! glucose catabolic process GO:0006007 66 54 1,000 0,09504124 0,15828736 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,09504124 0,15817282 ! DNA catabolic process GO:0006308 67 54 1,000 0,09504124 0,15805846 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,09504124 0,15794425 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,09504124 0,15783021 ! rRNA transcription GO:0009303 17 11 0,000 0,1008006 0,16727373 ! respiratory burst GO:0045730 14 11 0,000 0,1008006 0,16715313 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,1008006 0,1670327 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,1008006 0,16691245 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,1008006 0,16679236 ! virus-host interaction GO:0019048 17 11 0,000 0,1008006 0,16667246 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,1008006 0,16655272 ! RNA polyadenylation GO:0043631 19 11 0,000 0,1008006 0,16643316 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,1008006 0,16631376 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,1008006 0,16619454 ! mating GO:0007618 14 11 0,000 0,1008006 0,16607549 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,1008006 0,16595661 ! T cell proliferation GO:0042098 20 11 0,000 0,1008006 0,1658379 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,1008006 0,16571936 ! bone resorption GO:0045453 16 11 0,000 0,1008006 0,16560099 ! regulated secretory pathway GO:0045055 14 11 0,000 0,1008006 0,16548279 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,1008006 0,16536476 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,1008006 0,16524689 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,1008006 0,16512919 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,1008006 0,16501166 ! syncytium formation GO:0006949 15 11 0,000 0,1008006 0,1648943 ! plasma membrane organization GO:0007009 18 11 0,000 0,1008006 0,1647771 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,1008006 0,16466008 ! focal adhesion formation GO:0048041 24 11 0,000 0,1008006 0,16454321 ! mitotic spindle organization GO:0007052 15 11 0,000 0,1008006 0,16442652 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,1008006 0,16430998 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,1008006 0,16419362 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,1008006 0,16407741 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,1008006 0,16396138 ! temperature homeostasis GO:0001659 16 11 0,000 0,1008006 0,1638455 ! L-glutamate transport GO:0015813 16 11 0,000 0,1008006 0,16372979 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,1008006 0,16361425 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,1008006 0,16349886 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,1008006 0,16338364 ! stem cell development GO:0048864 29 11 0,000 0,1008006 0,16326858 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,1008006 0,16315369 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,1008006 0,16303895 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,1008006 0,16292438 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,1008006 0,16280996 ! vasoconstriction GO:0042310 15 11 0,000 0,1008006 0,16269571 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,1008006 0,16258162 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,1008006 0,16246769 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,1008006 0,16235391 ! ribosome assembly GO:0042255 13 11 0,000 0,1008006 0,1622403 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,1008006 0,16212684 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,1008006 0,16201355 ! chromatin silencing GO:0006342 19 11 0,000 0,1008006 0,16190041 ! nucleosome positioning GO:0016584 13 11 0,000 0,1008006 0,16178743 ! regulation of isotype switching GO:0045191 19 11 0,000 0,1008006 0,16167461 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,1008006 0,16156194 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,1008006 0,16144943 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,1008006 0,16133708 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,1008006 0,16122489 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,1008006 0,16111285 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,1008006 0,16100096 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,1008006 0,16088923 ! male genitalia development GO:0030539 13 11 0,000 0,1008006 0,16077766 ! cholesterol efflux GO:0033344 19 11 0,000 0,1008006 0,16066624 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,1008006 0,16055498 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,1008006 0,16044387 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,1008006 0,16033291 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,1008006 0,16022211 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,1008006 0,16011145 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,1008006 0,16000096 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,1008006 0,15989061 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,1008006 0,15978042 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,1008006 0,15967038 ! lysogeny GO:0030069 18 11 0,000 0,1008006 0,15956049 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,1008006 0,15945075 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,1008006 0,15934116 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,10104247 0,1596138 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,10104247 0,15950425 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,10408183 0,16418944 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 1,000 0,10408183 0,1640769 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,10408183 0,16396452 ! gonad development GO:0008406 79 57 1,000 0,10408183 0,16385229 ! lactation GO:0007595 20 12 0,000 0,10944725 0,17218103 ! tRNA modification GO:0006400 14 12 0,000 0,10944725 0,17206334 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,10944725 0,17194581 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10944725 0,17182844 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,10944725 0,17171123 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10944725 0,17159418 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10944725 0,17147729 ! non-recombinational repair GO:0000726 19 12 0,000 0,10944725 0,17136056 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10944725 0,17124399 ! peroxisomal transport GO:0043574 21 12 0,000 0,10944725 0,17112758 ! cartilage condensation GO:0001502 18 12 0,000 0,10944725 0,17101132 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,10944725 0,17089522 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10944725 0,17077928 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,10944725 0,1706635 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10944725 0,17054788 ! arginine metabolic process GO:0006525 13 12 0,000 0,10944725 0,17043241 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,10944725 0,17031709 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10944725 0,17020194 ! Golgi organization GO:0007030 18 12 0,000 0,10944725 0,17008694 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10944725 0,16997209 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10944725 0,1698574 ! monoamine transport GO:0015844 13 12 0,000 0,10944725 0,16974286 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10944725 0,16962848 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,10944725 0,16951425 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10944725 0,16940018 ! L-amino acid transport GO:0015807 20 12 0,000 0,10944725 0,16928626 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10944725 0,16917249 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10944725 0,16905888 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10944725 0,16894541 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,10944725 0,1688321 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10944725 0,16871894 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10944725 0,16860594 ! cerebellum development GO:0021549 13 12 0,000 0,10944725 0,16849308 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10944725 0,16838038 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,10944725 0,16826782 ! histone methylation GO:0016571 15 12 0,000 0,10944725 0,16815542 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10944725 0,16804317 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10944725 0,16793106 ! intestinal absorption GO:0050892 19 12 0,000 0,10944725 0,16781911 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10944725 0,16770731 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,10944725 0,16759565 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,10944725 0,16748414 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,10944725 0,16737278 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10944725 0,16726157 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,10944725 0,16715051 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,10944725 0,16703959 ! response to cold GO:0009409 14 12 0,000 0,10944725 0,16692882 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,11023419 0,16801765 ! actin filament organization GO:0007015 95 59 1,000 0,11023419 0,16790638 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,11334571 0,17253152 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,11334571 0,17241742 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,11334571 0,17230346 ! regulation of heart contraction GO:0008016 91 60 1,000 0,11334571 0,17218965 ! fertilization GO:0009566 68 60 1,000 0,11334571 0,172076 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,11647982 0,1767174 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,11647982 0,17660091 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11801123 0,1788049 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11801123 0,17868719 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,11801123 0,17856963 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11801123 0,17845223 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11801123 0,17833498 ! lipid localization GO:0010876 24 13 0,000 0,11801123 0,17821788 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11801123 0,17810094 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11801123 0,17798416 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11801123 0,17786752 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11801123 0,17775104 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,11801123 0,17763471 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11801123 0,17751853 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11801123 0,17740251 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11801123 0,17728663 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11801123 0,17717091 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11801123 0,17705534 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11801123 0,17693992 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,11801123 0,17682465 ! NAD metabolic process GO:0019674 21 13 0,000 0,11801123 0,17670953 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,11801123 0,17659456 ! bone mineralization GO:0030282 15 13 0,000 0,11801123 0,17647974 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11801123 0,17636507 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11801123 0,17625054 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11801123 0,17613617 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11801123 0,17602194 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11801123 0,17590787 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,11801123 0,17579394 ! genitalia development GO:0048806 15 13 0,000 0,11801123 0,17568015 ! regulation of cellular pH GO:0030641 20 13 0,000 0,11801123 0,17556652 ! cellular pigmentation GO:0033059 24 13 0,000 0,11801123 0,17545303 ! tissue regeneration GO:0042246 21 13 0,000 0,11801123 0,17533969 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11801123 0,17522649 ! cofactor transport GO:0051181 19 13 0,000 0,11801123 0,17511344 ! NADP metabolic process GO:0006739 18 13 0,000 0,11801123 0,17500054 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11801123 0,17488778 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11801123 0,17477517 ! gas transport GO:0015669 18 13 0,000 0,11801123 0,1746627 ! regulation of RNA stability GO:0043487 28 13 0,000 0,11801123 0,17455038 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11801123 0,1744382 ! regulation of axon extension GO:0030516 23 13 0,000 0,11801123 0,17432616 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11801123 0,17421427 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11801123 0,17410253 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11801123 0,17399092 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11801123 0,17387946 ! amine catabolic process GO:0009310 90 62 1,000 0,1196358 0,17616027 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,1196358 0,17604757 ! regulation of lipase activity GO:0060191 109 63 1,000 0,12281296 0,18060729 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,12601059 0,18519128 ! appendage morphogenesis GO:0035107 93 64 1,000 0,12601059 0,18507302 GO:0035108|limb morphogenesis, ! hexose catabolic process GO:0019320 82 64 1,000 0,12601059 0,18495492 ! adaptive immune response GO:0002250 94 64 1,000 0,12601059 0,18483696 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,12649335 0,18542684 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,12649335 0,18530873 ! superoxide anion generation GO:0042554 18 14 0,000 0,12649335 0,18519077 ! neuron maturation GO:0042551 21 14 0,000 0,12649335 0,18507297 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,12649335 0,18495531 ! myotube differentiation GO:0014902 21 14 0,000 0,12649335 0,18483781 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,12649335 0,18472045 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,12649335 0,18460324 ! inositol metabolic process GO:0006020 20 14 0,000 0,12649335 0,18448618 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,12649335 0,18436927 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,12649335 0,18425251 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,12649335 0,18413589 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,12649335 0,18401942 ! gene silencing by RNA GO:0031047 20 14 0,000 0,12649335 0,1839031 ! response to cAMP GO:0051591 19 14 0,000 0,12649335 0,18378693 ! limbic system development GO:0021761 25 14 0,000 0,12649335 0,1836709 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,12649335 0,18355502 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,12649335 0,18343929 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,12649335 0,1833237 ! glycine metabolic process GO:0006544 22 14 0,000 0,12649335 0,18320825 ! pituitary gland development GO:0021983 23 14 0,000 0,12649335 0,18309296 ! cellular response to starvation GO:0009267 21 14 0,000 0,12649335 0,1829778 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,12649335 0,1828628 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,12649335 0,18274793 ! regulation of heart rate GO:0002027 23 14 0,000 0,12649335 0,18263321 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,12649335 0,18251864 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,12649335 0,18240421 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,12649335 0,18228992 GO:0060675|ureteric bud morphogenesis, ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,12649335 0,18217577 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,12649335 0,18206177 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,12649335 0,18194791 ! axon cargo transport GO:0008088 27 14 0,000 0,12649335 0,18183419 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,12649335 0,18172062 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,12649335 0,18160718 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,12649335 0,18149389 ! mRNA splice site selection GO:0006376 26 14 0,000 0,12649335 0,18138074 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,12649335 0,18126773 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,12649335 0,18115486 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,12649335 0,18104213 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,12649335 0,18092954 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,12649335 0,1808171 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,12649335 0,18070479 ! muscle maintenance GO:0046716 19 14 0,000 0,12649335 0,18059262 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,12649335 0,18048059 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,12649335 0,1803687 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,12649335 0,18025694 ! cell killing GO:0001906 20 14 0,000 0,12649335 0,18014533 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,12649335 0,18003385 ! cilium assembly GO:0042384 20 14 0,000 0,12649335 0,17992252 ! peptide hormone secretion GO:0030072 23 14 0,000 0,12649335 0,17981131 ! appendage development GO:0048736 94 65 1,000 0,12922802 0,1835852 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,12922802 0,18347188 ! protein oligomerization GO:0051259 100 65 1,000 0,12922802 0,18335869 ! metencephalon development GO:0022037 19 15 0,000 0,13489438 0,19128056 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,13489438 0,1911627 ! skin development GO:0043588 25 15 0,000 0,13489438 0,19104499 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,13489438 0,19092743 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,13489438 0,19081 ! bile acid metabolic process GO:0008206 22 15 0,000 0,13489438 0,19069273 ! adult walking behavior GO:0007628 25 15 0,000 0,13489438 0,19057559 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,13489438 0,1904586 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,13489438 0,19034176 ! myoblast differentiation GO:0045445 27 15 0,000 0,13489438 0,19022506 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,13489438 0,1901085 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,13489438 0,18999208 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,13489438 0,18987581 ! response to osmotic stress GO:0006970 22 15 0,000 0,13489438 0,18975967 ! vesicle coating GO:0006901 25 15 0,000 0,13489438 0,18964368 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,13489438 0,18952784 ! DNA integration GO:0015074 22 15 0,000 0,13489438 0,18941213 ! peptide secretion GO:0002790 27 15 0,000 0,13489438 0,18929656 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,13489438 0,18918114 ! regulation of vasodilation GO:0042312 24 15 0,000 0,13489438 0,18906585 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,13489438 0,18895071 ! neuron recognition GO:0008038 22 15 0,000 0,13489438 0,18883571 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,13489438 0,18872084 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,13489438 0,18860612 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,13489438 0,18849153 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,13489438 0,18837709 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,13489438 0,18826278 ! biomineral formation GO:0031214 18 15 0,000 0,13489438 0,18814862 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,13489438 0,18803459 ! organic cation transport GO:0015695 19 15 0,000 0,13489438 0,18792069 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,13489438 0,18780694 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,13489438 0,18769333 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,13489438 0,18757985 ! peptide hormone processing GO:0016486 19 15 0,000 0,13489438 0,18746651 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,13489438 0,1873533 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,13899245 0,19292857 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,13899245 0,19281221 ! rhythmic process GO:0048511 105 68 1,000 0,13899245 0,19269599 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,14228248 0,19713838 ! protein secretion GO:0009306 27 16 0,000 0,14321508 0,19831107 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,14321508 0,19819175 ! hormone secretion GO:0046879 25 16 0,000 0,14321508 0,19807257 ! bone remodeling GO:0046849 24 16 0,000 0,14321508 0,19795354 ! endothelial cell migration GO:0043542 22 16 0,000 0,14321508 0,19783465 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,14321508 0,1977159 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14321508 0,19759729 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14321508 0,19747883 ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,14321508 0,19736051 ! protein polyubiquitination GO:0000209 26 16 0,000 0,14321508 0,19724233 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14321508 0,19712429 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,14321508 0,19700639 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,14321508 0,19688864 ! fructose metabolic process GO:0006000 20 16 0,000 0,14321508 0,19677102 ! regulation of protein binding GO:0043393 27 16 0,000 0,14321508 0,19665354 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,14321508 0,19653621 ! protein export from nucleus GO:0006611 24 16 0,000 0,14321508 0,19641901 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,14321508 0,19630196 ! DNA replication initiation GO:0006270 25 16 0,000 0,14321508 0,19618504 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14321508 0,19606827 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,14321508 0,19595163 ! diencephalon development GO:0021536 25 16 0,000 0,14321508 0,19583513 ! neural crest cell migration GO:0001755 24 16 0,000 0,14321508 0,19571877 ! G1 phase GO:0051318 27 16 0,000 0,14321508 0,19560255 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14321508 0,19548646 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,14321508 0,19537051 ! steroid catabolic process GO:0006706 22 16 0,000 0,14321508 0,1952547 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,14321508 0,19513903 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14321508 0,1950235 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,14321508 0,1949081 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,14321508 0,19479284 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14321508 0,19467771 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14321508 0,19456272 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14321508 0,19444787 ! nerve development GO:0021675 18 16 0,000 0,14321508 0,19433315 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,14321508 0,19421857 ! negative regulation of translation GO:0017148 22 16 0,000 0,14321508 0,19410412 ! response to metal ion GO:0010038 103 70 1,000 0,14558908 0,19720546 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,14558908 0,19708939 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,14891161 0,20146864 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,14891161 0,2013502 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,14891161 0,2012319 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,15145623 0,2045504 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,15145623 0,20443035 ! negative regulation of defense response GO:0031348 19 17 0,000 0,15145623 0,20431045 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,15145623 0,20419069 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,15145623 0,20407107 ! glycerol metabolic process GO:0006071 20 17 0,000 0,15145623 0,20395159 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,15145623 0,20383225 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,15145623 0,20371305 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,15145623 0,20359399 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,15145623 0,20347507 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,15145623 0,20335629 ! memory GO:0007613 25 17 0,000 0,15145623 0,20323765 ! keratinization GO:0031424 17 17 0,000 0,15145623 0,20311914 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,15145623 0,20300077 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,15145623 0,20288254 ! retinoid metabolic process GO:0001523 22 17 0,000 0,15145623 0,20276445 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,15145623 0,20264649 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,15145623 0,20252868 ! vacuolar transport GO:0007034 24 17 0,000 0,15145623 0,202411 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,15145623 0,20229345 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,15145623 0,20217604 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,15145623 0,20205877 ! membrane budding GO:0006900 29 17 0,000 0,15145623 0,20194164 ! heme metabolic process GO:0042168 27 17 0,000 0,15145623 0,20182464 ! actin filament bundle formation GO:0051017 26 17 0,000 0,15145623 0,20170777 ! neuromuscular junction development GO:0007528 23 17 0,000 0,15145623 0,20159104 ! body fluid secretion GO:0007589 27 17 0,000 0,15145623 0,20147445 ! stem cell differentiation GO:0048863 36 17 0,000 0,15145623 0,20135799 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,15145623 0,20124167 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,15145623 0,20112548 ! sensory perception of pain GO:0019233 23 17 0,000 0,15145623 0,20100942 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,15145623 0,2008935 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,15145623 0,20077771 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,15145623 0,20066205 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,15145623 0,20054653 ! cell-cell junction organization GO:0045216 25 17 0,000 0,15145623 0,20043114 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,15145623 0,20031588 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,15145623 0,20020076 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,15145623 0,20008577 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,15145623 0,19997091 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,15145623 0,19985618 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,15145623 0,19974158 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,15224947 0,20067266 ! protein import into nucleus GO:0006606 118 74 1,000 0,15896883 0,20940911 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,15896883 0,20928925 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,15961857 0,21002444 ! positive regulation of translation GO:0045727 28 18 0,000 0,15961857 0,20990436 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,15961857 0,20978441 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,15961857 0,2096646 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,15961857 0,20954493 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,15961857 0,20942539 ! cAMP metabolic process GO:0046058 33 18 0,000 0,15961857 0,209306 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,15961857 0,20918673 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,15961857 0,20906761 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,15961857 0,20894862 ! axis specification GO:0009798 26 18 0,000 0,15961857 0,20882976 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,15961857 0,20871104 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,15961857 0,20859245 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,15961857 0,208474 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,15961857 0,20835569 ! glutamine metabolic process GO:0006541 23 18 0,000 0,15961857 0,2082375 ! response to retinoic acid GO:0032526 25 18 0,000 0,15961857 0,20811945 ! pigmentation during development GO:0048066 31 18 0,000 0,15961857 0,20800154 ! central nervous system neuron development GO:0021954 30 18 0,000 0,15961857 0,20788376 ! fucose metabolic process GO:0006004 26 18 0,000 0,15961857 0,20776611 ! response to fungus GO:0009620 19 18 0,000 0,15961857 0,2076486 ! peptide cross-linking GO:0018149 31 18 0,000 0,15961857 0,20753121 ! heart process GO:0003015 27 18 0,000 0,15961857 0,20741396 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,15961857 0,20729685 GO:0006692|prostanoid metabolic process, ! detection of chemical stimulus GO:0009593 26 18 0,000 0,15961857 0,20717986 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,15961857 0,20706301 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,15961857 0,20694629 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,15961857 0,2068297 ! vitamin transport GO:0051180 24 18 0,000 0,15961857 0,20671324 ! hormone transport GO:0009914 27 18 0,000 0,15961857 0,20659691 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,15961857 0,20648072 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,15961857 0,20636465 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,15961857 0,20624872 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,15961857 0,20613291 ! cell-cell recognition GO:0009988 20 18 0,000 0,15961857 0,20601724 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,15961857 0,20590169 ! regulation of glucose import GO:0046324 21 18 0,000 0,15961857 0,20578628 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,15961857 0,20567099 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,15961857 0,20555583 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,15961857 0,2054408 ! response to inorganic substance GO:0010035 115 75 1,000 0,16234916 0,20883841 ! response to nutrient GO:0007584 104 75 1,000 0,16234916 0,20872167 ! nuclear import GO:0051170 121 75 1,000 0,16234916 0,20860507 ! cofactor biosynthetic process GO:0051188 92 75 1,000 0,16234916 0,20848859 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,1657425 0,21272754 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,16770286 0,21512359 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,16770286 0,21500367 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,16770286 0,21488389 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,16770286 0,21476425 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,16770286 0,21464474 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,16770286 0,21452536 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,16770286 0,21440611 ! regeneration GO:0031099 32 19 0,000 0,16770286 0,21428699 ! response to alkaloid GO:0043279 32 19 0,000 0,16770286 0,21416801 ! sensory perception of taste GO:0050909 23 19 0,000 0,16770286 0,21404916 ! smooth muscle contraction GO:0006939 36 19 0,000 0,16770286 0,21393044 ! peroxisome organization GO:0007031 29 19 0,000 0,16770286 0,21381186 ! digestive system process GO:0022600 30 19 0,000 0,16770286 0,2136934 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,16770286 0,21357508 ! response to vitamin A GO:0033189 26 19 0,000 0,16770286 0,21345688 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,16770286 0,21333882 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,16770286 0,21322089 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,16770286 0,21310309 ! response to starvation GO:0042594 30 19 0,000 0,16770286 0,21298542 ! sex determination GO:0007530 29 19 0,000 0,16770286 0,21286787 ! plasma membrane fusion GO:0045026 23 19 0,000 0,16770286 0,21275046 ! cytolysis GO:0019835 20 19 0,000 0,16770286 0,21263318 ! renal system process GO:0003014 35 19 0,000 0,16770286 0,21251603 ! vasodilation GO:0042311 33 19 0,000 0,16770286 0,212399 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,16770286 0,21228211 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,16770286 0,21216534 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,16770286 0,2120487 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,16770286 0,21193219 ! sarcomere organization GO:0045214 23 19 0,000 0,16770286 0,21181581 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,16770286 0,21169955 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,16770286 0,21158343 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,16770286 0,21146743 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,16770286 0,21135156 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,16770286 0,21123581 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,16770286 0,21112019 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,16914829 0,21282334 ! protein ubiquitination GO:0016567 125 77 1,000 0,16914829 0,21270698 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,16914829 0,21259075 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,16914829 0,21247464 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,17256599 0,21664944 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,17256599 0,21653124 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,17570985 0,22035586 ! iron ion transport GO:0006826 37 20 0,000 0,17570985 0,22023577 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,17570985 0,22011582 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,17570985 0,219996 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,17570985 0,2198763 ! response to vitamin GO:0033273 29 20 0,000 0,17570985 0,21975674 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,17570985 0,21963731 ! response to ethanol GO:0045471 37 20 0,000 0,17570985 0,219518 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,17570985 0,21939883 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,17570985 0,21927979 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,17570985 0,21916087 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,17570985 0,21904208 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,17570985 0,21892343 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,17570985 0,2188049 ! DNA modification GO:0006304 28 20 0,000 0,17570985 0,2186865 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,17570985 0,21856822 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,17570985 0,21845008 ! collagen catabolic process GO:0030574 25 20 0,000 0,17570985 0,21833206 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,17570985 0,21821417 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,17570985 0,21809641 ! alditol metabolic process GO:0019400 24 20 0,000 0,17570985 0,21797877 ! actin filament-based movement GO:0030048 34 20 0,000 0,17570985 0,21786127 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,17599504 0,21809731 ! cellular respiration GO:0045333 107 79 1,000 0,17599504 0,21797986 ! regulation of lyase activity GO:0051339 133 79 1,000 0,17599504 0,21786254 ! alcohol catabolic process GO:0046164 104 80 1,000 0,17943493 0,22200126 ! protein localization in nucleus GO:0034504 133 80 1,000 0,17943493 0,22188191 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,18288514 0,22602677 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,18364025 0,22683812 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,18364025 0,22671636 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,18364025 0,22659473 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,18364025 0,22647323 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,18364025 0,22635186 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,18364025 0,22623063 ! vesicle docking GO:0048278 27 21 0,000 0,18364025 0,22610952 ! phototransduction GO:0007602 25 21 0,000 0,18364025 0,22598854 ! dendrite development GO:0016358 35 21 0,000 0,18364025 0,22586769 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,18364025 0,22574697 ! ovarian follicle development GO:0001541 30 21 0,000 0,18364025 0,22562638 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,18364025 0,22550592 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,18364025 0,22538558 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,18364025 0,22526538 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,18364025 0,2251453 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,18364025 0,22502535 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,18364025 0,22490553 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,18364025 0,22478583 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,18364025 0,22466627 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,18364025 0,22454683 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,18364025 0,22442751 ! fatty acid transport GO:0015908 30 21 0,000 0,18364025 0,22430833 ! immunoglobulin production GO:0002377 33 21 0,000 0,18364025 0,22418927 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,18364025 0,22407033 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,18364025 0,22395153 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,18364025 0,22383285 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,18364025 0,22371429 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,18364025 0,22359586 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,18364025 0,22347756 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,18364025 0,22335938 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,18364025 0,22324132 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,18364025 0,22312339 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,18364025 0,22300559 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,18364025 0,22288791 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,18364025 0,22277035 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,18981446 0,23013877 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,19149481 0,23205377 ! viral genome replication GO:0019079 29 22 0,000 0,19149481 0,23193158 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,19149481 0,23180951 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,19149481 0,23168757 ! leukocyte adhesion GO:0007159 38 22 0,000 0,19149481 0,23156575 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,19149481 0,23144407 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,19149481 0,23132251 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,19149481 0,23120108 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,19149481 0,23107978 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,19149481 0,23095861 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,19149481 0,23083756 ! lysosome organization GO:0007040 37 22 0,000 0,19149481 0,23071664 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,19149481 0,23059584 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,19149481 0,23047518 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,19149481 0,23035464 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,19149481 0,23023422 ! membrane depolarization GO:0051899 35 22 0,000 0,19149481 0,23011393 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,19149481 0,22999377 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,19149481 0,22987373 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,19149481 0,22975382 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,19149481 0,22963403 ! protein tetramerization GO:0051262 39 22 0,000 0,19149481 0,22951436 ! rRNA metabolic process GO:0016072 107 85 1,000 0,196779 0,23572485 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,196779 0,23560214 ! transcription initiation GO:0006352 118 85 1,000 0,196779 0,23547955 ! regulation of membrane potential GO:0042391 128 85 1,000 0,196779 0,2353571 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,196779 0,23523477 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,19927424 0,2380939 ! neuron fate commitment GO:0048663 32 23 0,000 0,19927424 0,23797028 ! embryonic pattern specification GO:0009880 31 23 0,000 0,19927424 0,23784679 ! vesicle targeting GO:0006903 32 23 0,000 0,19927424 0,23772342 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,19927424 0,23760018 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,19927424 0,23747708 ! interaction with host GO:0051701 37 23 0,000 0,19927424 0,23735409 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,19927424 0,23723124 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,19927424 0,23710851 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,19927424 0,23698591 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,19927424 0,23686344 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,19927424 0,23674109 ! cell fate determination GO:0001709 45 23 0,000 0,19927424 0,23661887 ! pentose metabolic process GO:0019321 31 23 0,000 0,19927424 0,23649678 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,19927424 0,23637481 ! spermatid development GO:0007286 33 23 0,000 0,19927424 0,23625297 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,19927424 0,23613125 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,19927424 0,23600966 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,19927424 0,23588819 ! telomere organization GO:0032200 32 23 0,000 0,19927424 0,23576685 GO:0000723|telomere maintenance, ! regulation of amine transport GO:0051952 38 23 0,000 0,19927424 0,23564563 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,20027328 0,23670531 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,20377492 0,24072025 GO:0060538|skeletal muscle organ development, ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,20697926 0,24438003 ! initiation of viral infection GO:0019059 42 24 0,000 0,20697926 0,24425464 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,20697926 0,24412938 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,20697926 0,24400425 ! superoxide metabolic process GO:0006801 32 24 0,000 0,20697926 0,24387925 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,20697926 0,24375438 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,20697926 0,24362963 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,20697926 0,24350501 ! sperm motility GO:0030317 27 24 0,000 0,20697926 0,24338052 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,20697926 0,24325616 ! vacuole organization GO:0007033 39 24 0,000 0,20697926 0,24313192 ! receptor metabolic process GO:0043112 37 24 0,000 0,20697926 0,24300781 ! neural crest cell development GO:0014032 39 24 0,000 0,20697926 0,24288383 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,20697926 0,24275997 ! base-excision repair GO:0006284 31 24 0,000 0,20697926 0,24263624 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,20697926 0,24251263 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,20697926 0,24238915 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,20697926 0,2422658 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,20697926 0,24214257 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,20697926 0,24201947 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,20728348 0,24225204 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,20728348 0,242129 GO:0016054|organic acid catabolic process, ! regulation of neurogenesis GO:0050767 153 89 1,000 0,2107985 0,24610992 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,2107985 0,24598506 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,21461057 0,25030645 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,21461057 0,25017959 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,21461057 0,25005285 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,21461057 0,24992624 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,21461057 0,24979976 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,21461057 0,24967341 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,21461057 0,24954718 ! peptide transport GO:0015833 43 25 0,000 0,21461057 0,24942108 ! male gonad development GO:0008584 33 25 0,000 0,21461057 0,24929511 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,21461057 0,24916927 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,21461057 0,24904355 ! phospholipid transport GO:0015914 35 25 0,000 0,21461057 0,24891796 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,21461057 0,2487925 ! detection of light stimulus GO:0009583 30 25 0,000 0,21461057 0,24866716 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,21461057 0,24854195 ! leukocyte proliferation GO:0070661 39 25 0,000 0,21461057 0,24841687 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,21461057 0,24829191 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,2213779 0,25599255 ! cell fate commitment GO:0045165 141 92 1,000 0,2213779 0,25586391 ! positive regulation of immune response GO:0050778 121 92 1,000 0,2213779 0,2557354 ! sulfur metabolic process GO:0006790 118 92 1,000 0,2213779 0,25560702 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,22216889 0,25639159 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,22216889 0,25626301 ! regulation of pH GO:0006885 36 26 0,000 0,22216889 0,25613455 ! post-embryonic development GO:0009791 42 26 0,000 0,22216889 0,25600623 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,22216889 0,25587804 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,22216889 0,25574997 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,22216889 0,25562203 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,22216889 0,25549422 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,22216889 0,25536653 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,22216889 0,25523898 ! regulation of coagulation GO:0050818 39 26 0,000 0,22216889 0,25511155 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,22491439 0,25813528 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,22491439 0,25800653 ! response to oxidative stress GO:0006979 141 94 1,000 0,22845519 0,26193765 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,22965489 0,26318198 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,22965489 0,26305092 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,22965489 0,26291998 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,22965489 0,26278917 ! membrane docking GO:0022406 39 27 0,000 0,22965489 0,2626585 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,22965489 0,26252795 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,22965489 0,26239753 ! acute-phase response GO:0006953 42 27 0,000 0,22965489 0,26226725 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,22965489 0,26213709 ! myofibril assembly GO:0030239 36 27 0,000 0,22965489 0,26200706 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,22965489 0,26187716 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,22965489 0,26174739 ! lipid oxidation GO:0034440 38 27 0,000 0,22965489 0,26161775 GO:0019395|fatty acid oxidation, ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,22965489 0,26148824 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,22965489 0,26135885 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,22965489 0,26122959 ! gene silencing GO:0016458 41 27 0,000 0,22965489 0,26110046 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,23554811 0,2676683 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,23706926 0,26926386 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,23706926 0,26913095 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,23706926 0,26899818 ! cell junction assembly GO:0034329 56 28 0,000 0,23706926 0,26886554 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,23706926 0,26873303 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,23706926 0,26860064 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,23706926 0,26846839 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,23706926 0,26833627 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,23706926 0,26820428 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,23706926 0,26807242 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,23706926 0,26794069 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,23706926 0,26780909 ! mesoderm formation GO:0001707 46 28 0,000 0,23706926 0,26767762 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,23706926 0,26754627 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,23706926 0,26741506 ! BMP signaling pathway GO:0030509 40 28 0,000 0,23706926 0,26728397 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,23706926 0,26715302 ! regulation of innate immune response GO:0045088 38 29 0,000 0,2444127 0,27529345 ! ovulation cycle process GO:0022602 41 29 0,000 0,2444127 0,2751587 ! protein targeting to membrane GO:0006612 53 29 0,000 0,2444127 0,27502408 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,2444127 0,27488959 ! mismatch repair GO:0006298 34 29 0,000 0,2444127 0,27475524 ! muscle cell development GO:0055001 38 29 0,000 0,2444127 0,27462101 ! formation of primary germ layer GO:0001704 48 29 0,000 0,2444127 0,27448692 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,2444127 0,27435296 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,2444127 0,27421913 ! protein import GO:0017038 156 99 1,000 0,2462099 0,27610082 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,2462099 0,27596626 ! regulation of translation GO:0006417 151 100 1,000 0,24976829 0,27981835 ! protein localization in organelle GO:0033365 161 100 1,000 0,24976829 0,27968212 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,25168587 0,28169222 ! collagen metabolic process GO:0032963 40 30 0,000 0,25168587 0,28155521 ! organic anion transport GO:0015711 51 30 0,000 0,25168587 0,28141833 ! cholesterol transport GO:0030301 46 30 0,000 0,25168587 0,28128159 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,25168587 0,28114498 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,25168587 0,2810085 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,25168587 0,28087215 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,25168587 0,28073594 ! ceramide metabolic process GO:0006672 43 30 0,000 0,25168587 0,28059986 ! ovulation cycle GO:0042698 43 30 0,000 0,25168587 0,28046391 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,25168587 0,28032809 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,25168587 0,28019241 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,25168587 0,28005685 ! response to heat GO:0009408 41 30 0,000 0,25168587 0,27992143 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,25168587 0,27978613 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,25168587 0,27965097 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,25888945 0,28751605 ! negative regulation of secretion GO:0051048 49 31 0,000 0,25888945 0,28737728 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,25888945 0,28723865 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,25888945 0,28710016 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,25888945 0,2869618 ! odontogenesis GO:0042476 50 31 0,000 0,25888945 0,28682357 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,25888945 0,28668547 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,25888945 0,28654751 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,25888945 0,28640968 ! RNA modification GO:0009451 40 31 0,000 0,25888945 0,28627199 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,26602409 0,29401989 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,26602409 0,29387867 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,26602409 0,29373759 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,26602409 0,29359664 ! cytokine production GO:0001816 44 32 0,000 0,26602409 0,29345583 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,26602409 0,29331515 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,26602409 0,2931746 ! vesicle localization GO:0051648 47 32 0,000 0,26602409 0,29303419 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,27309044 0,30067402 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,27309044 0,30053015 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,27309044 0,30038643 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,27309044 0,30024284 ! ear morphogenesis GO:0042471 42 33 0,000 0,27309044 0,30009939 ! actomyosin structure organization GO:0031032 43 33 0,000 0,27309044 0,29995608 ! cell junction organization GO:0034330 63 33 0,000 0,27309044 0,2998129 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,27309044 0,29966986 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,27309044 0,29952695 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,27309044 0,29938419 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,27309044 0,29924155 ! lipid homeostasis GO:0055088 55 33 0,000 0,27309044 0,29909906 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,27309044 0,2989567 ! regulation of proteolysis GO:0030162 50 33 0,000 0,27309044 0,29881447 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,27309044 0,29867238 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,27309044 0,29853043 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,28008917 0,30603568 ! mRNA catabolic process GO:0006402 48 34 0,000 0,28008917 0,30589036 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,28008917 0,30574518 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,28008917 0,30560014 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,28008917 0,30545524 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,28008917 0,30531047 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,28008917 0,30516584 ! polyol metabolic process GO:0019751 44 34 0,000 0,28008917 0,30502135 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,28008917 0,304877 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,28702091 0,31227441 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,28702091 0,31212676 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,28702091 0,31197925 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,28702091 0,31183189 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,28702091 0,31168466 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,28702091 0,31153757 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,28702091 0,31139061 ! pigment metabolic process GO:0042440 61 35 0,000 0,28702091 0,3112438 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,29388631 0,31853841 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,29388631 0,31838837 ! organic ether metabolic process GO:0018904 46 36 0,000 0,29388631 0,31823847 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,29388631 0,31808871 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,29388631 0,31793909 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,30068598 0,32514234 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,30068598 0,32498954 ! ion transmembrane transport GO:0034220 56 37 0,000 0,30068598 0,3248369 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,30068598 0,32468439 ! regulation of protein secretion GO:0050708 51 37 0,000 0,30068598 0,32453203 ! amino acid activation GO:0043038 52 37 0,000 0,30068598 0,32437981 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,30068598 0,32422773 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,30742056 0,33133425 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,30742056 0,33117906 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,30742056 0,33102401 ! phagocytosis GO:0006909 60 38 0,000 0,30742056 0,33086911 ! maintenance of location in cell GO:0051651 69 38 0,000 0,30742056 0,33071435 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,31409067 0,3377319 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,31409067 0,33757408 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,31409067 0,33741641 ! male sex differentiation GO:0046661 53 39 0,000 0,31409067 0,33725889 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,31409067 0,33710151 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,31409067 0,33694428 ! regulation of tube size GO:0035150 60 40 0,000 0,32069691 0,34387082 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,32069691 0,34371058 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,32069691 0,34355049 ! peptide metabolic process GO:0006518 56 40 0,000 0,32069691 0,34339055 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,32069691 0,34323076 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,32069691 0,34307112 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,32723991 0,34990785 ! glucose transport GO:0015758 52 41 0,000 0,32723991 0,34974526 ! striated muscle contraction GO:0006941 62 41 0,000 0,32723991 0,34958281 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,32723991 0,34942051 ! biopolymer methylation GO:0043414 62 41 0,000 0,32723991 0,34925837 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,32723991 0,34909638 ! mitochondrial transport GO:0006839 60 42 0,000 0,33372025 0,3558445 ! cellular component disassembly GO:0022411 64 42 0,000 0,33372025 0,3556796 ! hexose transport GO:0008645 54 42 0,000 0,33372025 0,35551486 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,33372025 0,35535027 ! excretion GO:0007588 63 42 0,000 0,33372025 0,35518583 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,33372025 0,35502155 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,33372025 0,35485741 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,33372025 0,35469343 ! regulation of cell shape GO:0008360 78 42 0,000 0,33372025 0,3545296 ! activation of caspase activity GO:0006919 65 43 0,000 0,34013854 0,36118128 ! tRNA processing GO:0008033 49 43 0,000 0,34013854 0,36101461 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,34013854 0,36084809 ! methylation GO:0032259 64 43 0,000 0,34013854 0,36068172 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,34649537 0,36725316 ! regulation of ion transport GO:0043269 57 44 0,000 0,34649537 0,367084 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,34649537 0,36691499 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,34649537 0,36674614 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,34649537 0,36657744 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,34649537 0,3664089 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,34649537 0,36624051 ! RNA catabolic process GO:0006401 64 45 0,000 0,35279132 0,37272395 ! positive regulation of defense response GO:0031349 59 45 0,000 0,35279132 0,37255282 ! regulation of translational initiation GO:0006446 64 45 0,000 0,35279132 0,37238185 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,35279132 0,37221103 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,35279132 0,37204037 ! cell recognition GO:0008037 58 45 0,000 0,35279132 0,37186986 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,35902697 0,37826937 ! cell redox homeostasis GO:0045454 63 46 0,000 0,35902697 0,37809617 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,35902697 0,37792313 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,35902697 0,37775025 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,3652029 0,38407255 ! viral infectious cycle GO:0019058 71 47 0,000 0,3652029 0,38389702 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,3652029 0,38372164 ! chloride transport GO:0006821 67 48 0,000 0,37131967 0,38997043 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,37131967 0,38979245 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,37131967 0,38961462 ! response to temperature stimulus GO:0009266 62 48 0,000 0,37131967 0,38943696 ! gastrulation GO:0007369 73 48 0,000 0,37131967 0,38925946 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,37131967 0,38908212 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 0,000 0,37131967 0,38890494 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,37737785 0,39507012 ! sensory perception of smell GO:0007608 61 49 0,000 0,37737785 0,39489038 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,37737785 0,3947108 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,37737785 0,39453139 ! maintenance of location GO:0051235 84 49 0,000 0,37737785 0,39435214 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,383378 0,40044023 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,383378 0,40025846 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,383378 0,40007686 ! proton transport GO:0015992 75 50 0,000 0,383378 0,39989542 ! positive regulation of secretion GO:0051047 71 51 0,000 0,38932066 0,40591003 ! hydrogen transport GO:0006818 77 51 0,000 0,38932066 0,40572611 ! muscle fiber development GO:0048747 74 51 0,000 0,38932066 0,40554235 ! transition metal ion transport GO:0000041 74 52 0,000 0,39520639 0,41148696 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,39520639 0,41130077 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,40103572 0,41717873 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,40103572 0,41699013 ! amino acid transport GO:0006865 84 54 0,000 0,4068092 0,42280216 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,4068092 0,42261119 ! detection of external stimulus GO:0009581 66 54 0,000 0,4068092 0,42242039 ! exocytosis GO:0006887 74 55 0,000 0,41252736 0,42816468 ! mesoderm development GO:0007498 76 55 0,000 0,41252736 0,42797155 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,41252736 0,4277786 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,41252736 0,42758582 ! carbohydrate transport GO:0008643 74 57 0,000 0,42379981 0,43907188 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,42379981 0,43887419 ! secondary metabolic process GO:0019748 84 57 0,000 0,42379981 0,43867667 ! viral reproductive process GO:0022415 87 58 0,000 0,42935514 0,44422709 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,42935514 0,44402735 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,42935514 0,44382779 ! activation of MAPK activity GO:0000187 84 59 0,000 0,43485723 0,4493134 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,43485723 0,44911164 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,44030657 0,45453551 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,44030657 0,45433159 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,44030657 0,45412786 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,44570369 0,45948834 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,44570369 0,45928247 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,44570369 0,45907679 ! neurotransmitter transport GO:0006836 81 62 0,000 0,45104906 0,46437459 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,45104906 0,46416682 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,45104906 0,46395923 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,45634319 0,46919506 ! viral reproduction GO:0016032 92 63 0,000 0,45634319 0,46898541 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,46158657 0,47416217 ! regulation of caspase activity GO:0043281 97 65 0,000 0,46677967 0,4792827 ! defense response to bacterium GO:0042742 73 65 0,000 0,46677967 0,47906883 ! activation of immune response GO:0002253 83 65 0,000 0,46677967 0,47885515 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,47192298 0,48391567 ! antigen processing and presentation GO:0019882 96 66 0,000 0,47192298 0,48370002 ! axon guidance GO:0007411 99 66 0,000 0,47192298 0,48348457 ! regulation of immune effector process GO:0002697 101 66 0,000 0,47192298 0,4832693 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,47701697 0,48826837 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,47701697 0,48805117 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,47701697 0,48783416 ! acute inflammatory response GO:0002526 92 68 0,000 0,48206211 0,4927746 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,48206211 0,49255569 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,48206211 0,49233697 ! inorganic anion transport GO:0015698 93 68 0,000 0,48206211 0,49211845 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,48705887 0,49699885 ! humoral immune response GO:0006959 86 70 0,000 0,49200771 0,50182604 ! amine transport GO:0015837 101 70 0,000 0,49200771 0,5016036 ! muscle cell differentiation GO:0042692 104 71 0,000 0,49690908 0,50637611 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,49690908 0,50615185 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,50176344 0,51087026 ! regulation of blood pressure GO:0008217 107 73 0,000 0,50657124 0,5155371 ! mitochondrion organization GO:0007005 104 73 0,000 0,50657124 0,51530909 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,50657124 0,51508128 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,51133292 0,5196932 ! digestion GO:0007586 97 74 0,000 0,51133292 0,51946365 ! blood coagulation GO:0007596 116 75 0,000 0,51604891 0,52402318 GO:0050817|coagulation, ! tRNA metabolic process GO:0006399 95 76 0,000 0,52071967 0,52853276 ! response to unfolded protein GO:0006986 99 76 0,000 0,52071967 0,52829962 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,5253456 0,53275789 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,5253456 0,53252309 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,53446475 0,54152816 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,53446475 0,54128971 ! chromatin assembly GO:0031497 102 80 0,000 0,5389588 0,54560089 GO:0006334|nucleosome assembly, ! hemostasis GO:0007599 125 81 0,000 0,54340972 0,54986465 ! response to protein stimulus GO:0051789 111 81 0,000 0,54340972 0,54962285 ! vitamin metabolic process GO:0006766 103 81 0,000 0,54340972 0,54938125 ! detection of stimulus GO:0051606 108 82 0,000 0,54781792 0,55359456 ! regulation of defense response GO:0031347 117 84 0,000 0,55650781 0,5621291 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,55650781 0,56188234 ! sterol metabolic process GO:0016125 120 84 0,000 0,55650781 0,56163579 ! nucleosome organization GO:0034728 114 87 0,000 0,56923233 0,5742256 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,56923233 0,57397385 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,56923233 0,57372233 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,57339266 0,57766234 ! protein processing GO:0016485 114 88 0,000 0,57339266 0,57740942 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,57751305 0,58130417 ! hormone metabolic process GO:0042445 121 90 0,000 0,58159388 0,58515569 ! ATP metabolic process GO:0046034 137 91 0,000 0,58563552 0,58896445 ! response to virus GO:0009615 122 91 0,000 0,58563552 0,58870703 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,58963835 0,59247191 ! electron transport chain GO:0022900 123 94 0,000 0,59752906 0,60013836 ! carboxylic acid transport GO:0046942 147 95 0,000 0,60141767 0,60378029 GO:0015849|organic acid transport, ! protein maturation GO:0051604 129 96 0,000 0,60526893 0,60738156 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,60908319 0,61094258 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,60908319 0,61067626 ! calcium ion transport GO:0006816 167 99 0,000 0,61660215 0,61794551 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,62030754 0,62138822 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,62030754 0,6211177 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,62030754 0,62084741 ! divalent metal ion transport GO:0070838 171 100 0,000 0,62030754 0,62057736 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,62030754 0,62030754