pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6637-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 8,762E-06 0,02015336 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 1,451E-05 0,01668441 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 2,193E-05 0,01681324 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 5,141E-05 0,02956334 GO:0045936|negative regulation of phosphate metabolic process, ! glial cell migration GO:0008347 10 5 1,000 8,297E-05 0,0381684 ! regulation of sensory perception GO:0051931 6 5 1,000 8,297E-05 0,031807 GO:0051930|regulation of sensory perception of pain, ! axonal fasciculation GO:0007413 9 6 1,000 1,242E-04 0,04081834 ! neuron migration GO:0001764 46 34 2,000 1,313E-04 0,03775271 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,736E-04 0,04436363 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,985E-04 0,04565433 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 2,142E-04 0,04477702 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 2,31E-04 0,04428081 ! axon extension GO:0048675 11 8 1,000 2,31E-04 0,04087459 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,31E-04 0,03795498 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,31E-04 0,03542465 ! keratinocyte proliferation GO:0043616 12 8 1,000 2,31E-04 0,03321061 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 1,000 2,31E-04 0,03125704 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,31E-04 0,02952054 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,31E-04 0,02796683 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 2,659E-04 0,03057276 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,847E-04 0,0311833 ! motor axon guidance GO:0008045 14 9 1,000 2,965E-04 0,03099611 ! localization within membrane GO:0051668 15 9 1,000 2,965E-04 0,02964845 ! positive regulation of cell cycle GO:0045787 77 45 2,000 3,044E-04 0,02917436 ! response to UV GO:0009411 75 46 2,000 3,25E-04 0,02989993 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 3,464E-04 0,03064716 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of B cell proliferation GO:0030888 15 10 1,000 3,699E-04 0,03151119 ! hippocampus development GO:0021766 19 10 1,000 3,699E-04 0,03038579 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 3,699E-04 0,029338 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,513E-04 0,03459763 ! nitric oxide metabolic process GO:0046209 14 11 1,000 4,513E-04 0,03348158 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 1,000 4,513E-04 0,03243528 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 4,513E-04 0,03145239 GO:0042130|negative regulation of T cell proliferation, ! positive regulation of cell growth GO:0030307 16 12 1,000 5,405E-04 0,03656444 ! cell-cell junction assembly GO:0007043 18 12 1,000 5,405E-04 0,03551974 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 6,125E-04 0,03912958 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 6,376E-04 0,03963474 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,376E-04 0,03859172 ! negative regulation of kinase activity GO:0033673 100 58 2,000 6,445E-04 0,03801173 ! limbic system development GO:0021761 25 14 1,000 7,425E-04 0,04269272 ! startle response GO:0001964 21 14 1,000 7,425E-04 0,04165144 ! negative regulation of caspase activity GO:0043154 20 14 1,000 7,425E-04 0,04065974 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 7,425E-04 0,03971416 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 7,425E-04 0,03881157 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 7,425E-04 0,03794909 ! negative regulation of transferase activity GO:0051348 105 61 2,000 7,472E-04 0,03735894 ! positive regulation of cell size GO:0045793 20 15 1,000 8,551E-04 0,04184595 ! skin development GO:0043588 25 15 1,000 8,551E-04 0,04097416 ! cerebral cortex development GO:0021987 29 15 1,000 8,551E-04 0,04013795 ! neuron recognition GO:0008038 22 15 1,000 8,551E-04 0,03933519 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 8,551E-04 0,03856391 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of caspase activity GO:0043281 97 65 2,000 8,994E-04 0,03978217 ! protein amino acid deacetylation GO:0006476 20 16 1,000 9,755E-04 0,04233085 ! cellular response to unfolded protein GO:0034620 19 16 1,000 9,755E-04 0,04154695 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 9,755E-04 0,04079155 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 9,824E-04 0,04034798 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,103E-03 0,04452516 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 1,103E-03 0,04375749 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 1,103E-03 0,04301583 ! neuromuscular junction development GO:0007528 23 17 1,000 1,103E-03 0,0422989 ! sensory perception of pain GO:0019233 23 17 1,000 1,103E-03 0,04160548 ! cell-cell junction organization GO:0045216 25 17 1,000 1,103E-03 0,04093442 ! regulation of peptidase activity GO:0052547 106 72 2,000 1,211E-03 0,0441954 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,239E-03 0,04452899 ! negative regulation of T cell activation GO:0050868 25 18 1,000 1,239E-03 0,04384393 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,382E-03 0,04816968 ! vesicle docking during exocytosis GO:0006904 24 19 1,000 1,382E-03 0,04745073 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,382E-03 0,04675292 ! response to unfolded protein GO:0006986 99 76 2,000 1,415E-03 0,04717681 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 1,533E-03 0,05036947 ! pallium development GO:0021543 38 20 1,000 1,533E-03 0,04966004 ! positive regulation of B cell activation GO:0050871 31 20 1,000 1,533E-03 0,04897032 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 1,691E-03 0,05328423 ! vesicle docking GO:0048278 27 21 1,000 1,691E-03 0,05256418 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 1,691E-03 0,05186332 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 1,691E-03 0,05118091 ! response to protein stimulus GO:0051789 111 81 2,000 1,7E-03 0,05078524 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 1,857E-03 0,0547533 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 1,952E-03 0,05683566 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 2,019E-03 0,058035 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 2,03E-03 0,05763936 ! myelination GO:0042552 35 23 1,000 2,03E-03 0,05693644 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 2,03E-03 0,05625046 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 2,03E-03 0,05558081 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 2,03E-03 0,05492692 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 2,03E-03 0,05428823 ! interphase GO:0051325 159 88 2,000 2,156E-03 0,0569886 ! response to toxin GO:0009636 38 24 1,000 2,21E-03 0,05776981 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 2,21E-03 0,05712072 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 2,398E-03 0,06128362 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 2,593E-03 0,06553885 ! negative regulation of protein modification process GO:0031400 50 26 1,000 2,593E-03 0,06482647 ! response to light stimulus GO:0009416 153 96 2,000 2,761E-03 0,06828797 ! membrane docking GO:0022406 39 27 1,000 2,795E-03 0,0683955 ! respiratory gaseous exchange GO:0007585 47 27 1,000 2,795E-03 0,06767555 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 2,795E-03 0,06697059 ! cell junction assembly GO:0034329 56 28 1,000 3,005E-03 0,0712459 ! ensheathment of neurons GO:0007272 43 28 1,000 3,005E-03 0,0705189 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 3,005E-03 0,06980659 ! calcium ion transport GO:0006816 167 99 2,000 3,013E-03 0,06929079 ! divalent metal ion transport GO:0070838 171 100 2,000 3,099E-03 0,07058222 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 3,221E-03 0,07263691 ! telencephalon development GO:0021537 52 29 1,000 3,221E-03 0,0719317 ! adult locomotory behavior GO:0008344 47 30 1,000 3,445E-03 0,07618672 ! negative regulation of cell activation GO:0050866 44 30 1,000 3,445E-03 0,07546114 ! mammary gland development GO:0030879 57 31 1,000 3,676E-03 0,07975584 ! xenobiotic metabolic process GO:0006805 44 31 1,000 3,676E-03 0,07901046 ! peripheral nervous system development GO:0007422 53 32 1,000 3,913E-03 0,0833423 ! calcium-mediated signaling GO:0019722 50 32 1,000 3,913E-03 0,0825777 ! cell junction organization GO:0034330 63 33 1,000 4,158E-03 0,08694431 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 4,158E-03 0,08616103 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 4,158E-03 0,08539173 ! mRNA catabolic process GO:0006402 48 34 1,000 4,41E-03 0,08975876 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 4,668E-03 0,09418835 ! keratinocyte differentiation GO:0030216 47 35 1,000 4,668E-03 0,09336932 ! regulation of action potential in neuron GO:0019228 54 35 1,000 4,668E-03 0,09256441 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 4,668E-03 0,09177327 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 4,668E-03 0,09099553 ! response to xenobiotic stimulus GO:0009410 50 36 1,000 4,934E-03 0,09536115 ! gliogenesis GO:0042063 71 38 1,000 5,485E-03 0,10513276 ! regulation of T cell proliferation GO:0042129 58 38 1,000 5,485E-03 0,1042639 ! mesenchymal cell development GO:0014031 64 38 1,000 5,485E-03 0,10340928 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! synapse organization GO:0050808 55 39 1,000 5,771E-03 0,10791216 ! epidermal cell differentiation GO:0009913 53 40 1,000 6,063E-03 0,11246663 ! positive regulation of protein transport GO:0051222 55 40 1,000 6,063E-03 0,11156689 ! regulation of T cell differentiation GO:0045580 59 41 1,000 6,363E-03 0,11614156 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 6,668E-03 0,12076402 ! neuromuscular process GO:0050905 79 43 1,000 6,981E-03 0,12543243 ! regulation of action potential GO:0001508 71 44 1,000 7,299E-03 0,13014503 ! RNA catabolic process GO:0006401 64 45 1,000 7,625E-03 0,13490009 ! cell recognition GO:0008037 58 45 1,000 7,625E-03 0,13387032 ! histone modification GO:0016570 68 46 1,000 7,957E-03 0,13863767 ! covalent chromatin modification GO:0016569 75 47 1,000 8,295E-03 0,14344435 ! negative regulation of immune system process GO:0002683 73 47 1,000 8,295E-03 0,14237387 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 8,639E-03 0,14719039 ! regulation of angiogenesis GO:0045765 94 49 1,000 8,99E-03 0,15204335 ! regulation of intracellular transport GO:0032386 78 49 1,000 8,99E-03 0,15093354 ! skeletal muscle fiber development GO:0048741 73 50 1,000 9,348E-03 0,15579412 ! positive regulation of growth GO:0045927 67 50 1,000 9,348E-03 0,1546733 ! activation of phospholipase C activity GO:0007202 87 51 1,000 9,711E-03 0,15954067 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 9,711E-03 0,15840918 ! positive regulation of cell migration GO:0030335 92 51 1,000 9,711E-03 0,15729362 ! adult behavior GO:0030534 80 51 1,000 9,711E-03 0,15619367 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01008092 0,16101476 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,01083896 0,17192835 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01083896 0,17075076 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01083896 0,16958919 ! exocytosis GO:0006887 74 55 1,000 0,01122717 0,17447631 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,01162146 0,17939164 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,01162146 0,17819569 ! viral reproductive process GO:0022415 87 58 1,000 0,01242812 0,18930242 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,01242812 0,18805701 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,01411273 0,21215209 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01450322 0,21660659 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01450322 0,21520913 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01450322 0,21382958 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01450322 0,21246761 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01450322 0,21112288 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01450322 0,20979506 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01450322 0,20848384 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01450322 0,20718891 ! sleep GO:0030431 11 5 0,000 0,01450322 0,20590997 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01450322 0,20464671 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01450322 0,20339887 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01450322 0,20216615 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01450322 0,20094828 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01450322 0,199745 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01450322 0,19855604 ! tongue development GO:0043586 6 5 0,000 0,01450322 0,19738115 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01450322 0,19622009 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01450322 0,1950726 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01450322 0,19393846 ! cobalt ion transport GO:0006824 9 5 0,000 0,01450322 0,19281743 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01450322 0,19170928 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01450322 0,1906138 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01450322 0,18953076 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01450322 0,18845997 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01450322 0,18740121 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01450322 0,18635427 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01450322 0,18531897 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01450322 0,18429511 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01450322 0,1832825 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01450322 0,18228095 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01450322 0,1812903 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01450322 0,18031035 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01450322 0,17934094 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01450322 0,1783819 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01450322 0,17743306 ! malate metabolic process GO:0006108 7 5 0,000 0,01450322 0,17649426 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01450322 0,17556534 ! behavioral response to pain GO:0048266 7 5 0,000 0,01450322 0,17464615 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01450322 0,17373653 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01450322 0,17283634 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01450322 0,17194544 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01450322 0,17106366 ! mating behavior GO:0007617 6 5 0,000 0,01450322 0,17019089 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01450322 0,16932698 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01450322 0,16847179 ! rhythmic behavior GO:0007622 12 5 0,000 0,01450322 0,1676252 ! copulation GO:0007620 7 5 0,000 0,01450322 0,16678707 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01450322 0,16595729 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01450322 0,16513572 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01450322 0,16432224 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01450322 0,16351674 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01450322 0,1627191 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01450322 0,1619292 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01450322 0,16114693 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01450322 0,16037219 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01450322 0,15960485 ! response to protozoan GO:0001562 9 5 0,000 0,01450322 0,15884483 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01450322 0,15809201 ! lymph vessel development GO:0001945 7 5 0,000 0,01450322 0,15734629 ! endochondral ossification GO:0001958 12 5 0,000 0,01450322 0,15660758 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01450322 0,15587577 ! parathyroid gland development GO:0060017 8 5 0,000 0,01450322 0,15515077 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01450322 0,15443247 ! anagen GO:0042640 6 5 0,000 0,01450322 0,1537208 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01450322 0,15301566 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01450322 0,15231696 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01450322 0,15162461 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01450322 0,15093853 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01450322 0,15025862 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01450322 0,14958482 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01450322 0,14891703 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01450322 0,14825518 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01450322 0,14759918 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01450322 0,14694896 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01450322 0,14630445 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01450322 0,14566557 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01450322 0,14503224 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01450322 0,14440439 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01450322 0,14378196 ! ovulation GO:0030728 6 5 0,000 0,01450322 0,14316487 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01450322 0,14255305 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01450322 0,14194644 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01450322 0,14134498 ! response to pH GO:0009268 9 5 0,000 0,01450322 0,14074858 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01450322 0,1401572 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01450322 0,13957077 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01450322 0,13898923 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01450322 0,13841251 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01450322 0,13784056 ! polyol catabolic process GO:0046174 7 5 0,000 0,01450322 0,13727331 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01450322 0,13671072 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01450322 0,13615271 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01450322 0,13559925 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01450322 0,13505026 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01450322 0,1345057 ! urea metabolic process GO:0019627 6 5 0,000 0,01450322 0,13396552 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01450322 0,13342966 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01450322 0,13289807 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01450322 0,13237069 ! neutrophil activation GO:0042119 5 5 0,000 0,01450322 0,13184749 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01450322 0,1313284 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01450322 0,13081339 ! response to food GO:0032094 5 5 0,000 0,01450322 0,1303024 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01450322 0,12979539 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01450322 0,1292923 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01450322 0,12879311 ! forebrain neuron development GO:0021884 7 5 0,000 0,01450322 0,12829775 ! melanosome organization GO:0032438 7 5 0,000 0,01450322 0,12780619 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01450322 0,12731838 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01450322 0,12683428 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01450322 0,12635384 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01450322 0,12587704 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01450322 0,12540381 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01450322 0,12493414 ! nucleoside transport GO:0015858 6 5 0,000 0,01450322 0,12446796 ! nucleoside salvage GO:0043174 7 5 0,000 0,01450322 0,12400526 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01450322 0,12354598 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01450322 0,12309009 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01450322 0,12263755 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01450322 0,12218833 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01450322 0,12174239 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01450322 0,12129969 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01450322 0,1208602 ! depyrimidination GO:0045008 8 5 0,000 0,01450322 0,12042388 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01450322 0,1199907 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01450322 0,11956063 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01450322 0,11913362 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01450322 0,11870966 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01450322 0,1182887 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01450322 0,11787072 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01450322 0,11745568 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01450322 0,11704356 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01450322 0,11663432 ! monocyte differentiation GO:0030224 8 5 0,000 0,01450322 0,11622793 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01450322 0,11582436 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01450322 0,11542358 ! centrosome duplication GO:0051298 5 5 0,000 0,01450322 0,11502557 ! response to UV-C GO:0010225 6 5 0,000 0,01450322 0,11463029 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01450322 0,11423772 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01450322 0,11384783 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01450322 0,11346059 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01450322 0,11307598 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01450322 0,11269397 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01450322 0,11231453 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01450322 0,11193763 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01450322 0,11156326 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01450322 0,11119138 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01450322 0,11082198 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01450322 0,11045502 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01450322 0,11009048 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01450322 0,10972834 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01450322 0,10936857 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01450322 0,10901116 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01450322 0,10865607 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01450322 0,10830329 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01450322 0,1079528 ! neural tube patterning GO:0021532 6 5 0,000 0,01450322 0,10760456 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01450322 0,10725857 ! histone demethylation GO:0016577 9 5 0,000 0,01450322 0,10691479 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01450322 0,10657321 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01450322 0,1062338 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01450322 0,10589655 ! enteric nervous system development GO:0048484 8 5 0,000 0,01450322 0,10556144 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01450322 0,10522844 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01450322 0,10489753 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01450322 0,1045687 ! transcription termination GO:0006353 8 5 0,000 0,01450322 0,10424192 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01450322 0,10391718 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01450322 0,10359446 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01450322 0,10327373 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01450322 0,10295498 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01450322 0,1026382 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01450322 0,10232336 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01450322 0,10201044 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01450322 0,10169943 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01450322 0,10139032 ! apical protein localization GO:0045176 6 5 0,000 0,01450322 0,10108307 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01450322 0,10077769 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01450322 0,10047414 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01450322 0,10017242 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01450322 0,0998725 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01450322 0,09957437 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01450322 0,09927802 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01450322 0,09898343 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01450322 0,09869058 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01450322 0,09839945 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01450322 0,09811004 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01450322 0,09782233 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01450322 0,0975363 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01450322 0,09725194 ! neural plate development GO:0001840 6 5 0,000 0,01450322 0,09696923 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01450322 0,09668816 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01450322 0,09640871 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01450322 0,09613088 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01450322 0,09585464 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01450322 0,09557998 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01450322 0,0953069 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01450322 0,09503537 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01450322 0,09476538 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01450322 0,09449693 ! spindle assembly GO:0051225 5 5 0,000 0,01450322 0,09422998 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01450322 0,09396455 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01450322 0,0937006 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01450322 0,09343814 ! organ regeneration GO:0031100 7 5 0,000 0,01450322 0,09317714 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01450322 0,09291759 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01450322 0,09265948 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01450322 0,09240281 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01450322 0,09214755 GO:0055081|anion homeostasis, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,01454852 0,0921807 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,01454852 0,09192745 ! viral reproduction GO:0016032 92 63 1,000 0,01454852 0,0916756 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01454852 0,09142512 ! negative regulation of cell size GO:0045792 108 64 1,000 0,01499009 0,09394337 ! protein oligomerization GO:0051259 100 65 1,000 0,01543742 0,09648386 ! axon guidance GO:0007411 99 66 1,000 0,01589045 0,09904617 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,01681351 0,10451642 ! tRNA transcription GO:0009304 11 6 0,000 0,01737902 0,10774057 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01737902 0,10745095 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01737902 0,10716287 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01737902 0,10687634 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01737902 0,10659134 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01737902 0,10630785 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01737902 0,10602587 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01737902 0,10574538 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01737902 0,10546636 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01737902 0,10518882 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01737902 0,10491273 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01737902 0,10463809 ! prostate gland development GO:0030850 9 6 0,000 0,01737902 0,10436489 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01737902 0,1040931 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01737902 0,10382273 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01737902 0,10355376 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01737902 0,10328618 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01737902 0,10301998 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01737902 0,10275515 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01737902 0,10249167 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01737902 0,10222954 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01737902 0,10196875 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01737902 0,10170929 ! neuron adhesion GO:0007158 9 6 0,000 0,01737902 0,10145115 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01737902 0,10119431 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01737902 0,10093877 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01737902 0,10068451 ! signal peptide processing GO:0006465 8 6 0,000 0,01737902 0,10043154 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01737902 0,10017983 ! mRNA stabilization GO:0048255 15 6 0,000 0,01737902 0,09992938 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01737902 0,09968018 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01737902 0,09943222 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01737902 0,09918549 ! opsonization GO:0008228 8 6 0,000 0,01737902 0,09893998 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01737902 0,09869568 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01737902 0,09845259 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01737902 0,09821069 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01737902 0,09796998 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01737902 0,09773044 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01737902 0,09749208 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01737902 0,09725487 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01737902 0,09701881 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01737902 0,0967839 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01737902 0,09655013 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01737902 0,09631747 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01737902 0,09608594 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01737902 0,09585552 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01737902 0,0956262 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01737902 0,09539798 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01737902 0,09517084 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01737902 0,09494478 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01737902 0,09471979 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01737902 0,09449587 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01737902 0,094273 ! thymic T cell selection GO:0045061 12 6 0,000 0,01737902 0,09405118 ! protein lipoylation GO:0009249 10 6 0,000 0,01737902 0,0938304 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01737902 0,09361066 ! pigment granule organization GO:0048753 11 6 0,000 0,01737902 0,09339194 ! drug transport GO:0015893 6 6 0,000 0,01737902 0,09317425 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01737902 0,09295756 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01737902 0,09274188 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01737902 0,0925272 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01737902 0,09231351 ! histidine metabolic process GO:0006547 6 6 0,000 0,01737902 0,09210081 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01737902 0,09188908 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01737902 0,09167833 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01737902 0,09146854 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01737902 0,09125971 ! adenohypophysis development GO:0021984 10 6 0,000 0,01737902 0,09105183 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01737902 0,09084489 ! hyperosmotic response GO:0006972 8 6 0,000 0,01737902 0,09063889 ! microtubule nucleation GO:0007020 10 6 0,000 0,01737902 0,09043383 ! ER overload response GO:0006983 7 6 0,000 0,01737902 0,09022969 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01737902 0,09002647 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01737902 0,08982416 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01737902 0,08962276 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01737902 0,08942226 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01737902 0,08922266 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01737902 0,08902395 ! response to dietary excess GO:0002021 7 6 0,000 0,01737902 0,08882612 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01737902 0,08862916 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01737902 0,08843308 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01737902 0,08823786 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01737902 0,08804351 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01737902 0,08785 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01737902 0,08765735 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01737902 0,08746554 ! neuron apoptosis GO:0051402 8 6 0,000 0,01737902 0,08727457 ! organic alcohol transport GO:0015850 9 6 0,000 0,01737902 0,08708443 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01737902 0,08689511 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01737902 0,08670662 ! male sex determination GO:0030238 9 6 0,000 0,01737902 0,08651894 ! carnitine transport GO:0015879 8 6 0,000 0,01737902 0,08633208 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01737902 0,08614602 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01737902 0,08596076 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01737902 0,08577629 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01737902 0,08559262 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01737902 0,08540973 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01737902 0,08522762 ! parturition GO:0007567 12 6 0,000 0,01737902 0,08504628 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01737902 0,08486572 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01737902 0,08468591 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01737902 0,08450687 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01737902 0,08432859 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01737902 0,08415106 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01737902 0,08397427 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01737902 0,08379822 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01737902 0,08362291 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01737902 0,08344833 ! macrophage differentiation GO:0030225 10 6 0,000 0,01737902 0,08327448 ! astrocyte development GO:0014002 14 6 0,000 0,01737902 0,08310136 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01737902 0,08292895 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01737902 0,08275725 ! interaction with symbiont GO:0051702 8 6 0,000 0,01737902 0,08258626 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01737902 0,08241598 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01737902 0,0822464 ! eating behavior GO:0042755 6 6 0,000 0,01737902 0,08207752 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01737902 0,08190933 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01737902 0,08174182 ! response to copper ion GO:0046688 9 6 0,000 0,01737902 0,081575 ! DNA topological change GO:0006265 8 6 0,000 0,01737902 0,08140886 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01737902 0,0812434 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01737902 0,0810786 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01737902 0,08091448 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01737902 0,08075101 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01737902 0,08058821 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01737902 0,08042606 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01737902 0,08026456 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01737902 0,08010371 ! gas homeostasis GO:0033483 11 6 0,000 0,01737902 0,0799435 ! hair follicle maturation GO:0048820 7 6 0,000 0,01737902 0,07978394 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01737902 0,079625 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01737902 0,0794667 ! Schwann cell development GO:0014044 14 6 0,000 0,01737902 0,07930903 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01737902 0,07915198 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01737902 0,07899556 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01737902 0,07883975 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01737902 0,07868455 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01737902 0,07852996 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01737902 0,07837598 ! histone ubiquitination GO:0016574 7 6 0,000 0,01737902 0,07822261 ! regulation of meiosis GO:0040020 10 6 0,000 0,01737902 0,07806983 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01737902 0,07791764 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01737902 0,07776605 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01737902 0,07761505 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01737902 0,07746464 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01737902 0,0773148 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01737902 0,07716554 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01737902 0,07701686 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01737902 0,07686875 ! receptor internalization GO:0031623 9 6 0,000 0,01737902 0,07672121 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01737902 0,07657424 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01737902 0,07642782 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01737902 0,07628197 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01737902 0,07613667 ! protein deubiquitination GO:0016579 8 6 0,000 0,01737902 0,07599192 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01737902 0,07584773 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01737902 0,07570408 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01737902 0,07556097 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01737902 0,0754184 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01737902 0,07527637 ! midbrain development GO:0030901 6 6 0,000 0,01737902 0,07513487 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01737902 0,07499391 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01737902 0,07485347 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01737902 0,07471355 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01737902 0,07457416 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01737902 0,07443529 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01737902 0,07429694 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01737902 0,07415909 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01737902 0,07402176 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01737902 0,07388494 ! adult feeding behavior GO:0008343 6 6 0,000 0,01737902 0,07374862 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01737902 0,0736128 ! blastocyst growth GO:0001832 15 6 0,000 0,01737902 0,07347748 ! pigment granule transport GO:0051904 12 6 0,000 0,01737902 0,07334266 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01737902 0,07320834 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01737902 0,0730745 ! catecholamine transport GO:0051937 7 6 0,000 0,01737902 0,07294115 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01737902 0,07280829 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01737902 0,07267591 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01737902 0,07254401 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01737902 0,07241259 ! protein prenylation GO:0018342 10 6 0,000 0,01737902 0,07228165 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01737902 0,07215118 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01737902 0,07202117 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01737902 0,07189164 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01737902 0,07176257 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01737902 0,07163396 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01775899 0,07306918 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,01824005 0,07491447 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,0187266 0,07677573 GO:0045937|positive regulation of phosphate metabolic process, ! mitochondrion organization GO:0007005 104 73 1,000 0,01921862 0,07865273 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,01971607 0,08054524 ! negative regulation of growth GO:0045926 123 75 1,000 0,02021892 0,08245304 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02024659 0,08241976 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02024659 0,08227414 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02024659 0,08212904 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02024659 0,08198445 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02024659 0,08184036 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02024659 0,08169678 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02024659 0,0815537 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02024659 0,08141113 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02024659 0,08126905 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02024659 0,08112747 ! reproductive behavior GO:0019098 12 7 0,000 0,02024659 0,08098637 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02024659 0,08084577 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,02024659 0,08070566 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02024659 0,08056603 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02024659 0,08042688 ! oligopeptide transport GO:0006857 11 7 0,000 0,02024659 0,08028822 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02024659 0,08015003 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02024659 0,08001231 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02024659 0,07987507 ! RNA methylation GO:0001510 11 7 0,000 0,02024659 0,0797383 ! pericardium development GO:0060039 8 7 0,000 0,02024659 0,07960199 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02024659 0,07946615 ! fibril organization GO:0043206 13 7 0,000 0,02024659 0,07933078 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02024659 0,07919586 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02024659 0,0790614 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02024659 0,0789274 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02024659 0,07879385 ! lipoprotein transport GO:0042953 9 7 0,000 0,02024659 0,07866075 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02024659 0,0785281 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02024659 0,0783959 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02024659 0,07826414 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02024659 0,07813283 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02024659 0,07800195 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02024659 0,07787151 ! chemosensory behavior GO:0007635 9 7 0,000 0,02024659 0,07774151 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02024659 0,07761194 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02024659 0,0774828 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02024659 0,07735409 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02024659 0,07722581 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02024659 0,07709796 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02024659 0,07697052 ! reflex GO:0060004 12 7 0,000 0,02024659 0,07684351 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02024659 0,07671691 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02024659 0,07659073 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02024659 0,07646497 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02024659 0,07633961 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02024659 0,07621467 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02024659 0,07609014 ! spinal cord patterning GO:0021511 7 7 0,000 0,02024659 0,07596601 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02024659 0,07584229 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02024659 0,07571897 ! adrenal gland development GO:0030325 17 7 0,000 0,02024659 0,07559605 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02024659 0,07547353 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02024659 0,0753514 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02024659 0,07522967 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02024659 0,07510833 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02024659 0,07498738 ! endosome organization GO:0007032 10 7 0,000 0,02024659 0,07486682 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02024659 0,07474665 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02024659 0,07462687 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02024659 0,07450746 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02024659 0,07438844 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02024659 0,0742698 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02024659 0,07415154 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02024659 0,07403365 ! galactose metabolic process GO:0006012 10 7 0,000 0,02024659 0,07391613 ! vesicle fusion GO:0006906 15 7 0,000 0,02024659 0,07379899 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02024659 0,07368222 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02024659 0,07356582 ! organ growth GO:0035265 11 7 0,000 0,02024659 0,07344979 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02024659 0,07333412 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02024659 0,07321881 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02024659 0,07310387 ! retinol metabolic process GO:0042572 9 7 0,000 0,02024659 0,07298929 ! behavioral fear response GO:0001662 13 7 0,000 0,02024659 0,07287506 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02024659 0,0727612 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02024659 0,07264768 ! rRNA modification GO:0000154 12 7 0,000 0,02024659 0,07253452 ! protein heterooligomerization GO:0051291 10 7 0,000 0,02024659 0,07242172 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02024659 0,07230926 ! response to UV-B GO:0010224 11 7 0,000 0,02024659 0,07219715 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,02024659 0,07208539 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02024659 0,07197398 ! intermediate filament organization GO:0045109 11 7 0,000 0,02024659 0,07186291 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02024659 0,07175218 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02024659 0,07164179 ! fibrinolysis GO:0042730 9 7 0,000 0,02024659 0,07153174 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02024659 0,07142203 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02024659 0,07131266 ! B cell lineage commitment GO:0002326 17 7 0,000 0,02024659 0,07120362 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02024659 0,07109491 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02024659 0,07098653 ! response to tropane GO:0014073 13 7 0,000 0,02024659 0,07087849 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02024659 0,07077077 ! melanosome localization GO:0032400 10 7 0,000 0,02024659 0,07066338 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02024659 0,07055631 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02024659 0,07044957 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02024659 0,07034315 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02024659 0,07023705 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02024659 0,07013127 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02024659 0,07002581 ! mast cell activation GO:0045576 9 7 0,000 0,02024659 0,06992067 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02024659 0,06981584 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02024659 0,06971132 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02024659 0,06960712 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02024659 0,06950323 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02024659 0,06939965 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02024659 0,06929638 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,02024659 0,06919341 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02024659 0,06909075 ! T cell lineage commitment GO:0002360 12 7 0,000 0,02024659 0,06898839 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02024659 0,06888634 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02024659 0,06878459 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02024659 0,06868313 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02024659 0,06858198 ! response to tumor cell GO:0002347 12 7 0,000 0,02024659 0,06848112 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02024659 0,06838057 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02024659 0,0682803 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02024659 0,06818033 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02024659 0,06808065 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02024659 0,06798126 ! diuresis GO:0030146 12 7 0,000 0,02024659 0,06788216 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02024659 0,06778336 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02024659 0,06768483 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02024659 0,0675866 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02024659 0,06748864 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02024659 0,06739098 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02024659 0,06729359 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02024659 0,06719649 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02024659 0,06709966 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02024659 0,06700312 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02024659 0,06690685 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02024659 0,06681085 ! lymph node development GO:0048535 9 7 0,000 0,02024659 0,06671514 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02024659 0,06661969 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02024659 0,06652452 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02024659 0,06642962 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02024659 0,06633499 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02024659 0,06624063 ! ATP catabolic process GO:0006200 10 7 0,000 0,02024659 0,06614654 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02024659 0,06605272 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02024659 0,06595916 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02024659 0,06586586 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02024659 0,06577283 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02024659 0,06568006 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02024659 0,06558756 ! muscle adaptation GO:0043500 12 7 0,000 0,02024659 0,06549531 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02024659 0,06540332 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02024659 0,06531159 ! retina homeostasis GO:0001895 9 7 0,000 0,02024659 0,06522012 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02024659 0,0651289 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02024659 0,06503794 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02024659 0,06494723 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02024659 0,06485678 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02024659 0,06476657 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02024659 0,06467662 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02024659 0,06458691 ! regulation of protein transport GO:0051223 114 76 1,000 0,02072712 0,06602823 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 148 77 1,000 0,02124066 0,06757055 ! forebrain development GO:0030900 131 80 1,000 0,02281287 0,07247183 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02310596 0,07330166 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02310596 0,0732007 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02310596 0,07310001 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02310596 0,0729996 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02310596 0,07289946 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02310596 0,0727996 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02310596 0,07270001 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02310596 0,07260069 ! phosphate transport GO:0006817 10 8 0,000 0,02310596 0,07250165 ! N-glycan processing GO:0006491 12 8 0,000 0,02310596 0,07240287 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02310596 0,07230436 ! UTP metabolic process GO:0046051 8 8 0,000 0,02310596 0,07220612 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02310596 0,07210815 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02310596 0,07201044 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02310596 0,071913 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02310596 0,07181582 ! succinate metabolic process GO:0006105 14 8 0,000 0,02310596 0,0717189 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02310596 0,07162225 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02310596 0,07152585 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02310596 0,07142971 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02310596 0,07133384 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02310596 0,07123821 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02310596 0,07114285 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02310596 0,07104774 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02310596 0,07095288 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02310596 0,07085828 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02310596 0,07076392 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02310596 0,07066982 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02310596 0,07057597 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02310596 0,07048237 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02310596 0,07038902 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,02310596 0,07029591 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02310596 0,07020305 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02310596 0,07011043 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02310596 0,07001806 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02310596 0,06992593 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02310596 0,06983404 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02310596 0,0697424 ! melanin metabolic process GO:0006582 12 8 0,000 0,02310596 0,06965099 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02310596 0,06955983 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02310596 0,0694689 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02310596 0,06937821 ! macrophage activation GO:0042116 12 8 0,000 0,02310596 0,06928775 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02310596 0,06919754 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02310596 0,06910755 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02310596 0,0690178 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02310596 0,06892828 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02310596 0,068839 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02310596 0,06874994 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02310596 0,06866112 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02310596 0,06857253 ! ruffle organization GO:0031529 11 8 0,000 0,02310596 0,06848416 ! osteoblast development GO:0002076 13 8 0,000 0,02310596 0,06839602 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02310596 0,06830811 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02310596 0,06822042 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02310596 0,06813296 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02310596 0,06804572 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02310596 0,0679587 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02310596 0,06787191 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02310596 0,06778534 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02310596 0,06769899 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02310596 0,06761286 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02310596 0,06752695 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02310596 0,06744125 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02310596 0,06735578 ! segment specification GO:0007379 10 8 0,000 0,02310596 0,06727052 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02310596 0,06718547 ! cellular extravasation GO:0045123 11 8 0,000 0,02310596 0,06710064 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02310596 0,06701602 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02310596 0,06693162 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02310596 0,06684743 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02310596 0,06676345 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02310596 0,06667968 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02310596 0,06659612 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02310596 0,06651277 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02310596 0,06642963 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02310596 0,0663467 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02310596 0,06626397 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02310596 0,06618145 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02310596 0,06609914 ! icosanoid secretion GO:0032309 12 8 0,000 0,02310596 0,06601703 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02310596 0,06593512 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02310596 0,06585342 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02310596 0,06577191 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02310596 0,06569061 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02310596 0,06560951 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02310596 0,06552862 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02310596 0,06544792 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02310596 0,06536741 ! sterol catabolic process GO:0016127 9 8 0,000 0,02310596 0,06528711 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02310596 0,065207 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02310596 0,06512709 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02310596 0,06504738 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02310596 0,06496786 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02310596 0,06488853 ! prophase GO:0051324 11 8 0,000 0,02310596 0,0648094 ! S phase GO:0051320 8 8 0,000 0,02310596 0,06473046 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02310596 0,06465171 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02310596 0,06457316 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02310596 0,06449479 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02310596 0,06441661 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02310596 0,06433863 ! hormone catabolic process GO:0042447 13 8 0,000 0,02310596 0,06426083 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02310596 0,06418322 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02310596 0,0641058 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02310596 0,06402856 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02310596 0,06395151 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02310596 0,06387465 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02310596 0,06379797 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02310596 0,06372147 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02310596 0,06364516 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02310596 0,06356903 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02310596 0,06349308 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02310596 0,06341731 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02310596 0,06334172 ! regulation of embryonic development GO:0045995 16 8 0,000 0,02310596 0,06326632 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02310596 0,06319109 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02310596 0,06311604 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02310596 0,06304117 ! regulation of neurological system process GO:0031644 122 81 1,000 0,02334737 0,06362434 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,02334737 0,06354905 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,02388702 0,06494108 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,0244318 0,06634374 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,0255366 0,069262 ! regulation of protein localization GO:0032880 132 85 1,000 0,0255366 0,06918042 ! regulation of membrane potential GO:0042391 128 85 1,000 0,0255366 0,06909904 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02595714 0,07015444 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02595714 0,0700721 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02595714 0,06998995 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02595714 0,069908 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02595714 0,06982624 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02595714 0,06974466 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02595714 0,06966328 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02595714 0,06958209 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02595714 0,06950108 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02595714 0,06942027 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02595714 0,06933964 ! GTP metabolic process GO:0046039 9 9 0,000 0,02595714 0,0692592 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02595714 0,06917895 ! social behavior GO:0035176 14 9 0,000 0,02595714 0,06909888 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02595714 0,069019 ! artery development GO:0060840 19 9 0,000 0,02595714 0,0689393 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02595714 0,06885978 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02595714 0,06878045 ! response to pain GO:0048265 16 9 0,000 0,02595714 0,0687013 ! protein complex disassembly GO:0043241 17 9 0,000 0,02595714 0,06862233 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02595714 0,06854355 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02595714 0,06846494 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02595714 0,06838652 ! lung alveolus development GO:0048286 17 9 0,000 0,02595714 0,06830827 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02595714 0,06823021 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02595714 0,06815232 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02595714 0,06807461 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02595714 0,06799707 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02595714 0,06791972 ! protein targeting to ER GO:0045047 19 9 0,000 0,02595714 0,06784254 ! T cell selection GO:0045058 18 9 0,000 0,02595714 0,06776553 ! endoderm development GO:0007492 12 9 0,000 0,02595714 0,0676887 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02595714 0,06761204 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02595714 0,06753556 ! arginine catabolic process GO:0006527 10 9 0,000 0,02595714 0,06745924 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02595714 0,06738311 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02595714 0,06730714 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02595714 0,06723134 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02595714 0,06715572 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02595714 0,06708026 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02595714 0,06700497 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02595714 0,06692986 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02595714 0,06685491 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02595714 0,06678012 ! mannose metabolic process GO:0006013 9 9 0,000 0,02595714 0,06670551 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02595714 0,06663106 ! receptor clustering GO:0043113 15 9 0,000 0,02595714 0,06655678 ! epithelial cell development GO:0002064 10 9 0,000 0,02595714 0,06648266 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02595714 0,06640871 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02595714 0,06633492 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02595714 0,0662613 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02595714 0,06618784 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02595714 0,06611454 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02595714 0,06604141 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02595714 0,06596843 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02595714 0,06589562 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02595714 0,06582297 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02595714 0,06575047 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02595714 0,06567814 ! DNA ligation GO:0006266 14 9 0,000 0,02595714 0,06560597 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02595714 0,06553395 ! response to amine stimulus GO:0014075 13 9 0,000 0,02595714 0,0654621 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02595714 0,0653904 ! erythrocyte development GO:0048821 11 9 0,000 0,02595714 0,06531885 ! renal water homeostasis GO:0003091 14 9 0,000 0,02595714 0,06524747 ! postreplication repair GO:0006301 11 9 0,000 0,02595714 0,06517623 ! mRNA cleavage GO:0006379 13 9 0,000 0,02595714 0,06510516 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02595714 0,06503424 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02595714 0,06496347 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02595714 0,06489286 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02595714 0,0648224 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02595714 0,06475209 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02595714 0,06468194 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02595714 0,06461194 ! acid secretion GO:0046717 14 9 0,000 0,02595714 0,06454209 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02595714 0,06447239 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02595714 0,06440284 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02595714 0,06433344 ! purine base metabolic process GO:0006144 18 9 0,000 0,02595714 0,06426419 ! oocyte differentiation GO:0009994 12 9 0,000 0,02595714 0,06419509 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02595714 0,06412613 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02595714 0,06405733 ! spleen development GO:0048536 15 9 0,000 0,02595714 0,06398867 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02595714 0,06392016 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02595714 0,0638518 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02595714 0,06378358 ! detection of calcium ion GO:0005513 13 9 0,000 0,02595714 0,06371551 ! blastocyst formation GO:0001825 12 9 0,000 0,02595714 0,06364758 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02595714 0,0635798 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02595714 0,06351216 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02595714 0,06344467 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02595714 0,06337732 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02595714 0,06331011 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02595714 0,06324304 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02595714 0,06317612 ! prepulse inhibition GO:0060134 14 9 0,000 0,02595714 0,06310934 ! embryonic placenta development GO:0001892 12 9 0,000 0,02595714 0,06304269 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02595714 0,06297619 ! insulin secretion GO:0030073 17 9 0,000 0,02595714 0,06290983 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02595714 0,06284361 ! response to nicotine GO:0035094 16 9 0,000 0,02595714 0,06277753 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02595714 0,06271159 ! nucleus localization GO:0051647 15 9 0,000 0,02595714 0,06264578 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02595714 0,06258012 ! cell cycle arrest GO:0007050 150 86 1,000 0,02609655 0,06285034 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,0266615 0,06414377 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,0266615 0,06407674 ! regulation of T cell activation GO:0050863 128 89 1,000 0,02780623 0,06675817 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02880017 0,06907236 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02880017 0,06900041 ! neuron fate specification GO:0048665 11 10 0,000 0,02880017 0,06892861 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02880017 0,06885695 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02880017 0,06878545 ! thyroid gland development GO:0030878 19 10 0,000 0,02880017 0,0687141 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02880017 0,06864289 ! synapsis GO:0007129 13 10 0,000 0,02880017 0,06857183 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02880017 0,06850092 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02880017 0,06843015 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02880017 0,06835954 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02880017 0,06828906 ! sulfate transport GO:0008272 12 10 0,000 0,02880017 0,06821873 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02880017 0,06814855 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02880017 0,06807851 ! androgen metabolic process GO:0008209 13 10 0,000 0,02880017 0,06800861 ! phospholipid efflux GO:0033700 16 10 0,000 0,02880017 0,06793886 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02880017 0,06786925 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02880017 0,06779979 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02880017 0,06773046 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02880017 0,06766128 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02880017 0,06759223 ! pathogenesis GO:0009405 13 10 0,000 0,02880017 0,06752333 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02880017 0,06745457 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02880017 0,06738595 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02880017 0,06731747 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02880017 0,06724913 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02880017 0,06718092 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02880017 0,06711286 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02880017 0,06704493 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02880017 0,06697714 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02880017 0,06690948 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02880017 0,06684197 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02880017 0,06677459 ! response to X-ray GO:0010165 16 10 0,000 0,02880017 0,06670734 ! B cell proliferation GO:0042100 14 10 0,000 0,02880017 0,06664023 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02880017 0,06657326 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02880017 0,06650642 ! forebrain cell migration GO:0021885 17 10 0,000 0,02880017 0,06643971 ! lipid digestion GO:0044241 15 10 0,000 0,02880017 0,06637314 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02880017 0,0663067 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02880017 0,06624039 ! UV protection GO:0009650 14 10 0,000 0,02880017 0,06617422 ! entry into host cell GO:0030260 20 10 0,000 0,02880017 0,06610817 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02880017 0,06604226 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02880017 0,06597648 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02880017 0,06591084 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02880017 0,06584532 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02880017 0,06577993 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02880017 0,06571467 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02880017 0,06564954 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02880017 0,06558454 ! regulation of organ growth GO:0046620 11 10 0,000 0,02880017 0,06551967 ! response to dsRNA GO:0043331 18 10 0,000 0,02880017 0,06545493 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02880017 0,06539032 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02880017 0,06532583 ! embryonic axis specification GO:0000578 12 10 0,000 0,02880017 0,06526147 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02880017 0,06519723 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02880017 0,06513313 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02880017 0,06506915 ! cranial nerve development GO:0021545 12 10 0,000 0,02880017 0,06500529 ! fucose catabolic process GO:0019317 16 10 0,000 0,02880017 0,06494156 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02880017 0,06487795 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02880017 0,06481447 ! protein sumoylation GO:0016925 12 10 0,000 0,02880017 0,06475111 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02880017 0,06468788 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02880017 0,06462477 ! zymogen activation GO:0031638 14 10 0,000 0,02880017 0,06456178 ! salivary gland development GO:0007431 22 10 0,000 0,02880017 0,06449892 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02880017 0,06443618 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02880017 0,06437356 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02880017 0,06431106 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02880017 0,06424868 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02880017 0,06418642 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02880017 0,06412429 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02880017 0,06406227 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02880017 0,06400038 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02880017 0,0639386 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02880017 0,06387694 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02880017 0,0638154 ! detection of bacterium GO:0016045 10 10 0,000 0,02880017 0,06375398 ! embryonic gut development GO:0048566 11 10 0,000 0,02880017 0,06369268 ! activation of innate immune response GO:0002218 10 10 0,000 0,02880017 0,0636315 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02880017 0,06357043 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02880017 0,06350948 ! developmental induction GO:0031128 13 10 0,000 0,02880017 0,06344865 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02880017 0,06338793 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02880017 0,06332733 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02880017 0,06326685 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02880017 0,06320648 ! response to virus GO:0009615 122 91 1,000 0,02897054 0,06351977 ! response to oxidative stress GO:0006979 141 94 1,000 0,03075315 0,06736405 ! rRNA transcription GO:0009303 17 11 0,000 0,03163506 0,06922991 ! respiratory burst GO:0045730 14 11 0,000 0,03163506 0,0691641 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03163506 0,06909842 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03163506 0,06903286 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03163506 0,06896743 ! virus-host interaction GO:0019048 17 11 0,000 0,03163506 0,06890212 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,03163506 0,06883693 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,03163506 0,06877187 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03163506 0,06870693 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03163506 0,06864211 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,03163506 0,06857741 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03163506 0,06851284 ! mating GO:0007618 14 11 0,000 0,03163506 0,06844839 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03163506 0,06838406 ! T cell proliferation GO:0042098 20 11 0,000 0,03163506 0,06831985 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03163506 0,06825576 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,03163506 0,06819179 ! bone resorption GO:0045453 16 11 0,000 0,03163506 0,06812794 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03163506 0,06806421 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03163506 0,06800059 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03163506 0,0679371 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,03163506 0,06787373 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03163506 0,06781047 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03163506 0,06774733 ! syncytium formation GO:0006949 15 11 0,000 0,03163506 0,06768431 ! plasma membrane organization GO:0007009 18 11 0,000 0,03163506 0,06762141 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03163506 0,06755862 ! focal adhesion formation GO:0048041 24 11 0,000 0,03163506 0,06749595 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03163506 0,0674334 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03163506 0,06737096 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,03163506 0,06730864 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03163506 0,06724643 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03163506 0,06718434 ! adult heart development GO:0007512 11 11 0,000 0,03163506 0,06712236 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,03163506 0,06706049 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03163506 0,06699874 ! temperature homeostasis GO:0001659 16 11 0,000 0,03163506 0,06693711 ! L-glutamate transport GO:0015813 16 11 0,000 0,03163506 0,06687558 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03163506 0,06681417 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03163506 0,06675288 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03163506 0,06669169 ! stem cell development GO:0048864 29 11 0,000 0,03163506 0,06663062 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03163506 0,06656966 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03163506 0,06650881 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03163506 0,06644807 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03163506 0,06638744 ! vasoconstriction GO:0042310 15 11 0,000 0,03163506 0,06632692 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03163506 0,06626652 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03163506 0,06620622 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03163506 0,06614603 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03163506 0,06608595 ! ribosome assembly GO:0042255 13 11 0,000 0,03163506 0,06602599 ! chromatin silencing GO:0006342 19 11 0,000 0,03163506 0,06596613 ! nucleosome positioning GO:0016584 13 11 0,000 0,03163506 0,06590637 ! T cell homeostasis GO:0043029 20 11 0,000 0,03163506 0,06584673 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03163506 0,06578719 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,03163506 0,06572777 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03163506 0,06566844 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03163506 0,06560923 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03163506 0,06555012 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03163506 0,06549112 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03163506 0,06543223 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03163506 0,06537344 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03163506 0,06531475 ! male genitalia development GO:0030539 13 11 0,000 0,03163506 0,06525618 ! cholesterol efflux GO:0033344 19 11 0,000 0,03163506 0,0651977 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03163506 0,06513933 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03163506 0,06508107 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03163506 0,06502291 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,03163506 0,06496485 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,03163506 0,0649069 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03163506 0,06484905 ! defense response to fungus GO:0050832 12 11 0,000 0,03163506 0,06479131 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03163506 0,06473366 ! lysogeny GO:0030069 18 11 0,000 0,03163506 0,06467612 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03163506 0,06461868 ! acrosome reaction GO:0007340 13 11 0,000 0,03163506 0,06456135 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03163506 0,06450411 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,03196529 0,06511971 ! extracellular structure organization GO:0043062 156 99 1,000 0,03381844 0,068834 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,03381844 0,06877314 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,03444536 0,06998616 ! lactation GO:0007595 20 12 0,000 0,03446184 0,06995783 ! reproductive cellular process GO:0048610 14 12 0,000 0,03446184 0,06989614 ! tRNA modification GO:0006400 14 12 0,000 0,03446184 0,06983456 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03446184 0,06977308 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03446184 0,06971172 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,03446184 0,06965046 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03446184 0,06958931 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03446184 0,06952826 ! non-recombinational repair GO:0000726 19 12 0,000 0,03446184 0,06946733 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03446184 0,0694065 ! peroxisomal transport GO:0043574 21 12 0,000 0,03446184 0,06934578 ! cartilage condensation GO:0001502 18 12 0,000 0,03446184 0,06928516 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03446184 0,06922465 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03446184 0,06916424 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03446184 0,06910394 ! heart looping GO:0001947 15 12 0,000 0,03446184 0,06904375 ! palate development GO:0060021 15 12 0,000 0,03446184 0,06898366 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03446184 0,06892367 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03446184 0,06886379 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03446184 0,06880401 ! arginine metabolic process GO:0006525 13 12 0,000 0,03446184 0,06874434 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03446184 0,06868477 ! methionine metabolic process GO:0006555 13 12 0,000 0,03446184 0,0686253 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03446184 0,06856594 ! Golgi organization GO:0007030 18 12 0,000 0,03446184 0,06850667 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03446184 0,06844751 ! monoamine transport GO:0015844 13 12 0,000 0,03446184 0,06838846 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03446184 0,0683295 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,03446184 0,06827065 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03446184 0,0682119 ! L-amino acid transport GO:0015807 20 12 0,000 0,03446184 0,06815324 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03446184 0,06809469 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03446184 0,06803624 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03446184 0,06797789 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03446184 0,06791964 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03446184 0,06786149 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03446184 0,06780344 ! cerebellum development GO:0021549 13 12 0,000 0,03446184 0,06774549 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03446184 0,06768764 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03446184 0,06762988 ! histone acetylation GO:0016573 23 12 0,000 0,03446184 0,06757223 ! histone methylation GO:0016571 15 12 0,000 0,03446184 0,06751467 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03446184 0,06745721 ! gland morphogenesis GO:0022612 23 12 0,000 0,03446184 0,06739985 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03446184 0,06734258 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,03446184 0,06728542 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03446184 0,06722835 ! response to gamma radiation GO:0010332 20 12 0,000 0,03446184 0,06717137 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03446184 0,0671145 ! intestinal absorption GO:0050892 19 12 0,000 0,03446184 0,06705772 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03446184 0,06700103 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03446184 0,06694444 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,03446184 0,06688795 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03446184 0,06683155 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,03446184 0,06677525 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03446184 0,06671904 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03446184 0,06666293 ! microspike assembly GO:0030035 23 12 0,000 0,03446184 0,06660691 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03446184 0,06655098 ! response to cold GO:0009409 14 12 0,000 0,03446184 0,06649515 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03728052 0,0718736 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,03728052 0,0718134 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03728052 0,07175331 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03728052 0,07169331 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03728052 0,07163342 ! water transport GO:0006833 17 13 0,000 0,03728052 0,07157362 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03728052 0,07151393 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03728052 0,07145433 ! lipid localization GO:0010876 24 13 0,000 0,03728052 0,07139484 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03728052 0,07133544 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03728052 0,07127614 ! organelle fusion GO:0048284 28 13 0,000 0,03728052 0,07121694 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03728052 0,07115784 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03728052 0,07109884 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03728052 0,07103993 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03728052 0,07098113 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03728052 0,07092242 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03728052 0,0708638 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03728052 0,07080528 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03728052 0,07074686 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03728052 0,07068854 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03728052 0,07063031 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03728052 0,07057218 ! NAD metabolic process GO:0019674 21 13 0,000 0,03728052 0,07051414 ! exocrine system development GO:0035272 27 13 0,000 0,03728052 0,0704562 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03728052 0,07039836 ! bone mineralization GO:0030282 15 13 0,000 0,03728052 0,07034061 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03728052 0,07028295 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03728052 0,07022539 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03728052 0,07016792 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03728052 0,07011055 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03728052 0,07005327 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03728052 0,06999608 ! genitalia development GO:0048806 15 13 0,000 0,03728052 0,06993899 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03728052 0,06988199 ! cellular pigmentation GO:0033059 24 13 0,000 0,03728052 0,06982508 ! tissue regeneration GO:0042246 21 13 0,000 0,03728052 0,06976827 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03728052 0,06971154 ! cofactor transport GO:0051181 19 13 0,000 0,03728052 0,06965491 ! NADP metabolic process GO:0006739 18 13 0,000 0,03728052 0,06959838 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03728052 0,06954193 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03728052 0,06948558 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03728052 0,06942931 ! gas transport GO:0015669 18 13 0,000 0,03728052 0,06937314 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03728052 0,06931706 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03728052 0,06926107 ! regulation of axon extension GO:0030516 23 13 0,000 0,03728052 0,06920517 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03728052 0,06914935 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03728052 0,06909363 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03728052 0,069038 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03728052 0,06898246 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03728052 0,06892701 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03728052 0,06887165 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,04009114 0,07400451 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,04009114 0,07394517 ! superoxide anion generation GO:0042554 18 14 0,000 0,04009114 0,07388592 ! neuron maturation GO:0042551 21 14 0,000 0,04009114 0,07382676 ! regulation of S phase GO:0033261 18 14 0,000 0,04009114 0,0737677 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,04009114 0,07370873 ! myotube differentiation GO:0014902 21 14 0,000 0,04009114 0,07364986 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,04009114 0,07359108 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,04009114 0,07353239 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,04009114 0,0734738 ! inositol metabolic process GO:0006020 20 14 0,000 0,04009114 0,0734153 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,04009114 0,0733569 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,04009114 0,07329859 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,04009114 0,07324037 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,04009114 0,07318224 ! gene silencing by RNA GO:0031047 20 14 0,000 0,04009114 0,0731242 ! response to cAMP GO:0051591 19 14 0,000 0,04009114 0,07306626 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,04009114 0,07300841 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,04009114 0,07295065 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,04009114 0,07289298 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,04009114 0,0728354 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,04009114 0,07277792 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,04009114 0,07272052 ! glycine metabolic process GO:0006544 22 14 0,000 0,04009114 0,07266322 ! pituitary gland development GO:0021983 23 14 0,000 0,04009114 0,072606 ! cellular response to starvation GO:0009267 21 14 0,000 0,04009114 0,07254888 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,04009114 0,07249184 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,04009114 0,0724349 ! regulation of heart rate GO:0002027 23 14 0,000 0,04009114 0,07237804 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,04009114 0,07232127 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,04009114 0,07226459 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,04009114 0,07220801 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,04009114 0,0721515 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,04009114 0,07209509 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,04009114 0,07203877 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,04009114 0,07198253 ! axon cargo transport GO:0008088 27 14 0,000 0,04009114 0,07192638 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,04009114 0,07187032 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,04009114 0,07181435 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,04009114 0,07175846 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,04009114 0,07170266 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04009114 0,07164695 ! mRNA splice site selection GO:0006376 26 14 0,000 0,04009114 0,07159132 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,04009114 0,07153578 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,04009114 0,07148033 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,04009114 0,07142496 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,04009114 0,07136968 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,04009114 0,07131448 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,04009114 0,07125937 ! muscle maintenance GO:0046716 19 14 0,000 0,04009114 0,07120434 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,04009114 0,0711494 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,04009114 0,07109454 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,04009114 0,07103977 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,04009114 0,07098508 ! cell killing GO:0001906 20 14 0,000 0,04009114 0,07093048 ! cilium assembly GO:0042384 20 14 0,000 0,04009114 0,07087596 ! peptide hormone secretion GO:0030072 23 14 0,000 0,04009114 0,07082152 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04289371 0,07571415 ! metencephalon development GO:0022037 19 15 0,000 0,04289371 0,07565609 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04289371 0,07559812 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,04289371 0,07554023 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,04289371 0,07548243 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04289371 0,07542473 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04289371 0,07536711 ! lipid phosphorylation GO:0046834 23 15 0,000 0,04289371 0,07530957 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,04289371 0,07525213 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04289371 0,07519477 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04289371 0,0751375 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04289371 0,07508032 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,04289371 0,07502323 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04289371 0,07496622 ! adult walking behavior GO:0007628 25 15 0,000 0,04289371 0,07490929 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04289371 0,07485246 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04289371 0,07479571 ! myoblast differentiation GO:0045445 27 15 0,000 0,04289371 0,07473905 ! centrosome cycle GO:0007098 16 15 0,000 0,04289371 0,07468247 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04289371 0,07462598 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04289371 0,07456957 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,04289371 0,07451325 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04289371 0,07445701 ! response to osmotic stress GO:0006970 22 15 0,000 0,04289371 0,07440086 ! vesicle coating GO:0006901 25 15 0,000 0,04289371 0,07434479 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,04289371 0,07428881 ! DNA integration GO:0015074 22 15 0,000 0,04289371 0,07423291 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,04289371 0,0741771 ! peptide secretion GO:0002790 27 15 0,000 0,04289371 0,07412137 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04289371 0,07406572 ! regulation of vasodilation GO:0042312 24 15 0,000 0,04289371 0,07401016 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,04289371 0,07395468 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04289371 0,07389928 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04289371 0,07384397 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,04289371 0,07378874 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,04289371 0,07373359 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04289371 0,07367852 ! biomineral formation GO:0031214 18 15 0,000 0,04289371 0,07362354 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04289371 0,07356864 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04289371 0,07351382 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04289371 0,07345908 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04289371 0,07340442 ! organic cation transport GO:0015695 19 15 0,000 0,04289371 0,07334984 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04289371 0,07329535 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04289371 0,07324094 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,04289371 0,0731866 ! defense response to virus GO:0051607 27 15 0,000 0,04289371 0,07313235 ! peptide hormone processing GO:0016486 19 15 0,000 0,04289371 0,07307818 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04289371 0,07302409 ! protein secretion GO:0009306 27 16 0,000 0,04568826 0,07772412 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,04568826 0,07766667 ! hormone secretion GO:0046879 25 16 0,000 0,04568826 0,07760931 ! bone remodeling GO:0046849 24 16 0,000 0,04568826 0,07755204 ! endothelial cell migration GO:0043542 22 16 0,000 0,04568826 0,07749484 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,04568826 0,07743774 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04568826 0,07738071 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,04568826 0,07732377 ! glial cell development GO:0021782 24 16 0,000 0,04568826 0,07726692 ! patterning of blood vessels GO:0001569 24 16 0,000 0,04568826 0,07721015 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,04568826 0,07715346 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,04568826 0,07709685 ! protein polyubiquitination GO:0000209 26 16 0,000 0,04568826 0,07704033 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,04568826 0,07698389 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,04568826 0,07692753 ! fructose metabolic process GO:0006000 20 16 0,000 0,04568826 0,07687126 ! regulation of protein binding GO:0043393 27 16 0,000 0,04568826 0,07681506 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,04568826 0,07675895 ! protein export from nucleus GO:0006611 24 16 0,000 0,04568826 0,07670293 ! negative regulation of immune response GO:0050777 28 16 0,000 0,04568826 0,07664698 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,04568826 0,07659111 ! DNA replication initiation GO:0006270 25 16 0,000 0,04568826 0,07653533 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,04568826 0,07647963 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,04568826 0,07642401 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,04568826 0,07636847 ! diencephalon development GO:0021536 25 16 0,000 0,04568826 0,07631301 ! oogenesis GO:0048477 23 16 0,000 0,04568826 0,07625763 ! neural crest cell migration GO:0001755 24 16 0,000 0,04568826 0,07620233 ! G1 phase GO:0051318 27 16 0,000 0,04568826 0,07614711 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,04568826 0,07609197 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,04568826 0,07603691 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,04568826 0,07598193 ! steroid catabolic process GO:0006706 22 16 0,000 0,04568826 0,07592703 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,04568826 0,07587221 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,04568826 0,07581747 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,04568826 0,0757628 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,04568826 0,07570822 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,04568826 0,07565371 ! sperm-egg recognition GO:0035036 16 16 0,000 0,04568826 0,07559929 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,04568826 0,07554494 ! nerve development GO:0021675 18 16 0,000 0,04568826 0,07549067 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,04568826 0,07543647 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,04568826 0,07538236 ! negative regulation of translation GO:0017148 22 16 0,000 0,04568826 0,07532832 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04847482 0,07986538 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04847482 0,07980821 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04847482 0,07975113 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04847482 0,07969412 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04847482 0,0796372 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04847482 0,07958035 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04847482 0,07952359 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04847482 0,07946691 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04847482 0,07941031 ! signal complex assembly GO:0007172 29 17 0,000 0,04847482 0,07935379 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04847482 0,07929735 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04847482 0,07924099 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04847482 0,07918471 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04847482 0,07912851 ! memory GO:0007613 25 17 0,000 0,04847482 0,07907239 ! keratinization GO:0031424 17 17 0,000 0,04847482 0,07901635 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04847482 0,07896039 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04847482 0,07890451 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04847482 0,07884871 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,04847482 0,07879299 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04847482 0,07873734 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04847482 0,07868178 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04847482 0,07862629 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04847482 0,07857088 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,04847482 0,07851555 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04847482 0,07846029 ! membrane budding GO:0006900 29 17 0,000 0,04847482 0,07840512 ! heme metabolic process GO:0042168 27 17 0,000 0,04847482 0,07835002 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04847482 0,078295 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04847482 0,07824005 ! body fluid secretion GO:0007589 27 17 0,000 0,04847482 0,07818519 ! stem cell differentiation GO:0048863 36 17 0,000 0,04847482 0,0781304 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04847482 0,07807568 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04847482 0,07802105 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04847482 0,07796649 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04847482 0,077912 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04847482 0,07785759 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04847482 0,07780326 ! synaptogenesis GO:0007416 24 17 0,000 0,04847482 0,07774901 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,04847482 0,07769483 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04847482 0,07764072 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04847482 0,07758669 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04847482 0,07753274 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04847482 0,07747886 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04847482 0,07742505 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04847482 0,07737132 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04847482 0,07731767 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04847482 0,07726409 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,05125339 0,08163628 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,05125339 0,08157979 ! positive regulation of translation GO:0045727 28 18 0,000 0,05125339 0,08152337 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,05125339 0,08146703 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,05125339 0,08141077 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,05125339 0,08135459 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,05125339 0,08129848 ! cAMP metabolic process GO:0046058 33 18 0,000 0,05125339 0,08124245 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,05125339 0,0811865 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,05125339 0,08113062 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,05125339 0,08107482 ! axis specification GO:0009798 26 18 0,000 0,05125339 0,0810191 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,05125339 0,08096346 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,05125339 0,08090789 ! pancreas development GO:0031016 26 18 0,000 0,05125339 0,0808524 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,05125339 0,08079698 ! glutamine metabolic process GO:0006541 23 18 0,000 0,05125339 0,08074164 ! response to retinoic acid GO:0032526 25 18 0,000 0,05125339 0,08068638 ! pigmentation during development GO:0048066 31 18 0,000 0,05125339 0,08063119 ! central nervous system neuron development GO:0021954 30 18 0,000 0,05125339 0,08057607 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,05125339 0,08052103 ! fucose metabolic process GO:0006004 26 18 0,000 0,05125339 0,08046607 ! response to fungus GO:0009620 19 18 0,000 0,05125339 0,08041118 ! peptide cross-linking GO:0018149 31 18 0,000 0,05125339 0,08035637 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,05125339 0,08030163 ! heart process GO:0003015 27 18 0,000 0,05125339 0,08024697 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,05125339 0,08019238 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,05125339 0,08013786 ! visual learning GO:0008542 35 18 0,000 0,05125339 0,08008342 ! somitogenesis GO:0001756 24 18 0,000 0,05125339 0,08002905 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,05125339 0,07997476 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,05125339 0,07992054 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,05125339 0,07986639 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,05125339 0,07981232 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,05125339 0,07975832 ! vitamin transport GO:0051180 24 18 0,000 0,05125339 0,07970439 ! hormone transport GO:0009914 27 18 0,000 0,05125339 0,07965054 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,05125339 0,07959676 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,05125339 0,07954305 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,05125339 0,07948941 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,05125339 0,07943585 ! cell-cell recognition GO:0009988 20 18 0,000 0,05125339 0,07938235 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,05125339 0,07932893 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,05125339 0,07927558 ! regulation of glucose import GO:0046324 21 18 0,000 0,05125339 0,07922231 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,05125339 0,0791691 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,05125339 0,07911597 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,05125339 0,07906291 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,05402401 0,08328098 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,05402401 0,0832252 ! positive regulation of ossification GO:0045778 30 19 0,000 0,05402401 0,08316949 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,05402401 0,08311386 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,05402401 0,0830583 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,05402401 0,08300282 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,05402401 0,08294741 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,05402401 0,08289207 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,05402401 0,08283681 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,05402401 0,08278162 ! regeneration GO:0031099 32 19 0,000 0,05402401 0,08272651 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,05402401 0,08267147 ! response to alkaloid GO:0043279 32 19 0,000 0,05402401 0,0826165 ! sensory perception of taste GO:0050909 23 19 0,000 0,05402401 0,08256161 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,05402401 0,08250678 ! smooth muscle contraction GO:0006939 36 19 0,000 0,05402401 0,08245203 ! peroxisome organization GO:0007031 29 19 0,000 0,05402401 0,08239736 ! digestive system process GO:0022600 30 19 0,000 0,05402401 0,08234275 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,05402401 0,08228822 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,05402401 0,08223376 ! response to vitamin A GO:0033189 26 19 0,000 0,05402401 0,08217938 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,05402401 0,08212506 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,05402401 0,08207082 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,05402401 0,08201664 ! response to starvation GO:0042594 30 19 0,000 0,05402401 0,08196254 ! sex determination GO:0007530 29 19 0,000 0,05402401 0,08190851 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,05402401 0,08185456 ! plasma membrane fusion GO:0045026 23 19 0,000 0,05402401 0,08180067 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,05402401 0,08174685 ! cytolysis GO:0019835 20 19 0,000 0,05402401 0,08169311 ! renal system process GO:0003014 35 19 0,000 0,05402401 0,08163943 ! vasodilation GO:0042311 33 19 0,000 0,05402401 0,08158583 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,05402401 0,08153229 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,05402401 0,08147883 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,05402401 0,08142544 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,05402401 0,08137211 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,05402401 0,08131886 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,05402401 0,08126567 ! sarcomere organization GO:0045214 23 19 0,000 0,05402401 0,08121256 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,05402401 0,08115951 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,05402401 0,08110654 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,05402401 0,08105363 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,05402401 0,08100079 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,05402401 0,08094802 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,05402401 0,08089532 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,05402401 0,08084269 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,05402401 0,08079013 ! protein stabilization GO:0050821 26 19 0,000 0,05402401 0,08073763 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,05678669 0,08481129 ! iron ion transport GO:0006826 37 20 0,000 0,05678669 0,08475626 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,05678669 0,08470129 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,05678669 0,0846464 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,05678669 0,08459158 ! response to vitamin GO:0033273 29 20 0,000 0,05678669 0,08453682 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,05678669 0,08448214 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,05678669 0,08442753 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,05678669 0,08437299 ! spinal cord development GO:0021510 31 20 0,000 0,05678669 0,08431852 ! response to ethanol GO:0045471 37 20 0,000 0,05678669 0,08426412 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,05678669 0,0842098 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,05678669 0,08415554 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,05678669 0,08410135 ! chromosome condensation GO:0030261 31 20 0,000 0,05678669 0,08404723 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,05678669 0,08399318 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,05678669 0,0839392 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,05678669 0,08388529 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,05678669 0,08383145 ! DNA modification GO:0006304 28 20 0,000 0,05678669 0,08377767 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,05678669 0,08372397 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,05678669 0,08367033 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,05678669 0,08361677 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,05678669 0,08356327 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,05678669 0,08350984 ! collagen catabolic process GO:0030574 25 20 0,000 0,05678669 0,08345648 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,05678669 0,08340319 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,05678669 0,08334996 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,05678669 0,08329681 ! alditol metabolic process GO:0019400 24 20 0,000 0,05678669 0,08324372 ! actin filament-based movement GO:0030048 34 20 0,000 0,05678669 0,0831907 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05954147 0,08717083 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05954147 0,08711538 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05954147 0,08706 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05954147 0,08700469 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05954147 0,08694944 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05954147 0,08689427 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05954147 0,08683917 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05954147 0,08678414 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,05954147 0,08672918 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05954147 0,08667429 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05954147 0,08661947 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05954147 0,08656471 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05954147 0,08651003 ! phototransduction GO:0007602 25 21 0,000 0,05954147 0,08645541 ! dendrite development GO:0016358 35 21 0,000 0,05954147 0,08640087 ! visual behavior GO:0007632 39 21 0,000 0,05954147 0,08634639 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05954147 0,08629198 ! ovarian follicle development GO:0001541 30 21 0,000 0,05954147 0,08623764 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05954147 0,08618337 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05954147 0,08612917 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05954147 0,08607503 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05954147 0,08602096 ! cell aging GO:0007569 32 21 0,000 0,05954147 0,08596696 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05954147 0,08591303 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05954147 0,08585917 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05954147 0,08580537 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05954147 0,08575164 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05954147 0,08569798 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05954147 0,08564439 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05954147 0,08559086 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,05954147 0,0855374 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05954147 0,085484 ! fatty acid transport GO:0015908 30 21 0,000 0,05954147 0,08543068 ! immunoglobulin production GO:0002377 33 21 0,000 0,05954147 0,08537742 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05954147 0,08532422 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,05954147 0,08527109 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05954147 0,08521803 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05954147 0,08516503 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05954147 0,0851121 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,05954147 0,08505924 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05954147 0,08500644 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05954147 0,08495371 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05954147 0,08490104 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05954147 0,08484844 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05954147 0,0847959 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05954147 0,08474343 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05954147 0,08469102 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05954147 0,08463867 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,06228835 0,08848871 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,06228835 0,08843408 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,06228835 0,08837953 ! viral genome replication GO:0019079 29 22 0,000 0,06228835 0,08832504 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,06228835 0,08827062 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,06228835 0,08821626 ! leukocyte adhesion GO:0007159 38 22 0,000 0,06228835 0,08816198 ! molting cycle process GO:0022404 40 22 0,000 0,06228835 0,08810776 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,06228835 0,0880536 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,06228835 0,08799952 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,06228835 0,0879455 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,06228835 0,08789154 ! vasculogenesis GO:0001570 33 22 0,000 0,06228835 0,08783765 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,06228835 0,08778383 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,06228835 0,08773008 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,06228835 0,08767639 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,06228835 0,08762276 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,06228835 0,0875692 ! lysosome organization GO:0007040 37 22 0,000 0,06228835 0,08751571 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,06228835 0,08746228 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,06228835 0,08740892 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,06228835 0,08735562 ! regulation of behavior GO:0050795 38 22 0,000 0,06228835 0,08730239 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,06228835 0,08724922 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,06228835 0,08719611 ! membrane depolarization GO:0051899 35 22 0,000 0,06228835 0,08714307 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,06228835 0,0870901 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,06228835 0,08703719 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,06228835 0,08698434 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,06228835 0,08693156 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,06228835 0,08687884 ! blastocyst development GO:0001824 37 22 0,000 0,06228835 0,08682619 ! neural tube closure GO:0001843 33 22 0,000 0,06228835 0,0867736 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,06228835 0,08672107 ! protein tetramerization GO:0051262 39 22 0,000 0,06228835 0,08666861 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,06502737 0,09042501 ! neuron fate commitment GO:0048663 32 23 0,000 0,06502737 0,09037037 ! embryonic pattern specification GO:0009880 31 23 0,000 0,06502737 0,0903158 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,06502737 0,09026129 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,06502737 0,09020685 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,06502737 0,09015248 ! vesicle targeting GO:0006903 32 23 0,000 0,06502737 0,09009817 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,06502737 0,09004393 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,06502737 0,08998975 ! osteoblast differentiation GO:0001649 40 23 0,000 0,06502737 0,08993563 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,06502737 0,08988159 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,06502737 0,0898276 ! interaction with host GO:0051701 37 23 0,000 0,06502737 0,08977369 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,06502737 0,08971983 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,06502737 0,08966604 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,06502737 0,08961232 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,06502737 0,08955866 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,06502737 0,08950506 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,06502737 0,08945153 ! cell fate determination GO:0001709 45 23 0,000 0,06502737 0,08939806 ! pentose metabolic process GO:0019321 31 23 0,000 0,06502737 0,08934466 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,06502737 0,08929132 ! spermatid development GO:0007286 33 23 0,000 0,06502737 0,08923804 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,06502737 0,08918483 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,06502737 0,08913168 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,06502737 0,08907859 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,06502737 0,08902557 ! telomere organization GO:0032200 32 23 0,000 0,06502737 0,08897261 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,06502737 0,08891971 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,06502737 0,08886688 ! regulation of amine transport GO:0051952 38 23 0,000 0,06502737 0,08881411 ! liver development GO:0001889 40 23 0,000 0,06502737 0,0887614 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,06775855 0,09243456 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,06775855 0,09237977 ! initiation of viral infection GO:0019059 42 24 0,000 0,06775855 0,09232504 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06775855 0,09227038 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06775855 0,09221578 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06775855 0,09216125 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06775855 0,09210678 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,06775855 0,09205237 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,06775855 0,09199803 ! fat cell differentiation GO:0045444 37 24 0,000 0,06775855 0,09194376 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06775855 0,09188954 ! sperm motility GO:0030317 27 24 0,000 0,06775855 0,0918354 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,06775855 0,09178131 ! vacuole organization GO:0007033 39 24 0,000 0,06775855 0,09172729 ! receptor metabolic process GO:0043112 37 24 0,000 0,06775855 0,09167333 ! neural crest cell development GO:0014032 39 24 0,000 0,06775855 0,09161944 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,06775855 0,09156561 ! negative regulation of cell development GO:0010721 56 24 0,000 0,06775855 0,09151184 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,06775855 0,09145814 ! base-excision repair GO:0006284 31 24 0,000 0,06775855 0,0914045 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,06775855 0,09135092 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,06775855 0,0912974 ! glutathione metabolic process GO:0006749 29 24 0,000 0,06775855 0,09124395 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,06775855 0,09119056 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06775855 0,09113723 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06775855 0,09108397 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,0704819 0,09468947 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,0704819 0,0946342 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,0704819 0,09457898 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,0704819 0,09452384 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,0704819 0,09446875 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,0704819 0,09441373 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,0704819 0,09435878 ! peptide transport GO:0015833 43 25 0,000 0,0704819 0,09430389 ! male gonad development GO:0008584 33 25 0,000 0,0704819 0,09424906 ! iron ion homeostasis GO:0055072 39 25 0,000 0,0704819 0,09419429 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,0704819 0,09413959 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,0704819 0,09408496 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,0704819 0,09403038 ! phospholipid transport GO:0015914 35 25 0,000 0,0704819 0,09397587 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,0704819 0,09392143 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,0704819 0,09386704 ! detection of light stimulus GO:0009583 30 25 0,000 0,0704819 0,09381272 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,0704819 0,09375846 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,0704819 0,09370427 ! leukocyte proliferation GO:0070661 39 25 0,000 0,0704819 0,09365013 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,07319746 0,09720217 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,07319746 0,09714608 ! translational initiation GO:0006413 43 26 0,000 0,07319746 0,09709005 ! regulation of pH GO:0006885 36 26 0,000 0,07319746 0,09703409 ! circadian rhythm GO:0007623 42 26 0,000 0,07319746 0,0969782 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,07319746 0,09692237 ! post-embryonic development GO:0009791 42 26 0,000 0,07319746 0,0968666 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,07319746 0,0968109 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,07319746 0,09675526 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,07319746 0,09669969 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,07319746 0,09664418 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,07319746 0,09658873 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,07319746 0,09653334 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,07319746 0,09647802 ! regulation of coagulation GO:0050818 39 26 0,000 0,07319746 0,09642277 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,07590523 0,09993248 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,07590523 0,09987531 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,07590523 0,0998182 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,07590523 0,09976116 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,07590523 0,09970419 ! catechol metabolic process GO:0009712 43 27 0,000 0,07590523 0,09964728 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,07590523 0,09959044 ! acute-phase response GO:0006953 42 27 0,000 0,07590523 0,09953366 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,07590523 0,09947694 ! myofibril assembly GO:0030239 36 27 0,000 0,07590523 0,09942029 GO:0055002|striated muscle cell development, ! response to ionizing radiation GO:0010212 47 27 0,000 0,07590523 0,09936371 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,07590523 0,09930719 ! natural killer cell activation GO:0030101 35 27 0,000 0,07590523 0,09925073 ! lipid oxidation GO:0034440 38 27 0,000 0,07590523 0,09919434 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,07590523 0,09913801 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,07590523 0,09908175 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,07590523 0,09902555 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,07590523 0,09896941 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,07590523 0,09891334 ! gene silencing GO:0016458 41 27 0,000 0,07590523 0,09885733 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,07860525 0,10231584 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,07860525 0,10225796 ! phenol metabolic process GO:0018958 44 28 0,000 0,07860525 0,10220016 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,07860525 0,10214242 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,07860525 0,10208474 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,07860525 0,10202713 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,07860525 0,10196959 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,07860525 0,10191211 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,07860525 0,10185469 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,07860525 0,10179734 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,07860525 0,10174006 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,07860525 0,10168284 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,07860525 0,10162568 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,07860525 0,10156858 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,07860525 0,10151156 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,07860525 0,10145459 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,07860525 0,10139769 ! mesoderm formation GO:0001707 46 28 0,000 0,07860525 0,10134085 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,07860525 0,10128408 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,07860525 0,10122737 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,07860525 0,10117072 ! BMP signaling pathway GO:0030509 40 28 0,000 0,07860525 0,10111414 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,07860525 0,10105762 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,07860525 0,10100116 ! neural tube formation GO:0001841 41 28 0,000 0,07860525 0,10094477 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,07860525 0,10088844 ! placenta development GO:0001890 37 28 0,000 0,07860525 0,10083217 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,08129754 0,10422761 ! regulation of innate immune response GO:0045088 38 29 0,000 0,08129754 0,10416955 ! ovulation cycle process GO:0022602 41 29 0,000 0,08129754 0,10411155 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,08129754 0,10405361 ! protein targeting to membrane GO:0006612 53 29 0,000 0,08129754 0,10399574 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,08129754 0,10393793 ! mismatch repair GO:0006298 34 29 0,000 0,08129754 0,10388019 ! muscle cell development GO:0055001 38 29 0,000 0,08129754 0,10382251 ! formation of primary germ layer GO:0001704 48 29 0,000 0,08129754 0,10376489 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,08129754 0,10370734 ! eye morphogenesis GO:0048592 51 29 0,000 0,08129754 0,10364985 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,08129754 0,10359243 ! tissue homeostasis GO:0001894 42 29 0,000 0,08129754 0,10353507 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,08398211 0,10689477 ! collagen metabolic process GO:0032963 40 30 0,000 0,08398211 0,10683565 ! organic anion transport GO:0015711 51 30 0,000 0,08398211 0,10677659 ! cholesterol transport GO:0030301 46 30 0,000 0,08398211 0,1067176 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,08398211 0,10665867 ! spliceosome assembly GO:0000245 49 30 0,000 0,08398211 0,10659981 ! spindle organization GO:0007051 37 30 0,000 0,08398211 0,10654101 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,08398211 0,10648228 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,08398211 0,10642361 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,08398211 0,10636501 ! ceramide metabolic process GO:0006672 43 30 0,000 0,08398211 0,10630647 ! ovulation cycle GO:0042698 43 30 0,000 0,08398211 0,10624799 ! hindbrain development GO:0030902 45 30 0,000 0,08398211 0,10618958 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,08398211 0,10613124 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,08398211 0,10607295 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,08398211 0,10601474 ! response to heat GO:0009408 41 30 0,000 0,08398211 0,10595658 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,08398211 0,10589849 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,08398211 0,10584047 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,08665899 0,10915426 ! negative regulation of secretion GO:0051048 49 31 0,000 0,08665899 0,10909451 ! glial cell differentiation GO:0010001 55 31 0,000 0,08665899 0,10903483 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,08665899 0,10897522 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,08665899 0,10891567 ! odontogenesis GO:0042476 50 31 0,000 0,08665899 0,10885618 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,08665899 0,10879677 ! segmentation GO:0035282 41 31 0,000 0,08665899 0,10873741 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,08665899 0,10867812 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,08665899 0,1086189 ! metanephros development GO:0001656 58 31 0,000 0,08665899 0,10855974 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,08665899 0,10850064 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,08665899 0,10844161 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,08665899 0,10838264 ! cell fate specification GO:0001708 37 31 0,000 0,08665899 0,10832374 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,08665899 0,1082649 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,08665899 0,10820612 ! RNA modification GO:0009451 40 31 0,000 0,08665899 0,10814741 ! regulation of muscle development GO:0048634 48 32 0,000 0,0893282 0,11141804 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,0893282 0,11135765 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,0893282 0,11129732 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,0893282 0,11123706 ! meiosis I GO:0007127 52 32 0,000 0,0893282 0,11117687 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,0893282 0,11111674 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,0893282 0,11105668 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,0893282 0,11099668 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,0893282 0,11093675 ! regulation of protein stability GO:0031647 48 32 0,000 0,0893282 0,11087688 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,0893282 0,11081708 ! cytokine production GO:0001816 44 32 0,000 0,0893282 0,11075734 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,0893282 0,11069766 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,0893282 0,11063805 ! vesicle localization GO:0051648 47 32 0,000 0,0893282 0,1105785 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,09198976 0,11381197 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,09198976 0,11375078 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,09198976 0,11368966 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,09198976 0,1136286 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,09198976 0,11356761 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,09198976 0,11350668 ! sister chromatid segregation GO:0000819 46 33 0,000 0,09198976 0,11344582 ! ear morphogenesis GO:0042471 42 33 0,000 0,09198976 0,11338502 ! actomyosin structure organization GO:0031032 43 33 0,000 0,09198976 0,11332429 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,09198976 0,11326362 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,09198976 0,11320302 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,09198976 0,11314249 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,09198976 0,11308202 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,09198976 0,11302161 ! female gonad development GO:0008585 49 33 0,000 0,09198976 0,11296127 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,09198976 0,11290099 ! positive regulation of cell development GO:0010720 54 33 0,000 0,09198976 0,11284077 ! lipid homeostasis GO:0055088 55 33 0,000 0,09198976 0,11278062 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,09198976 0,11272054 ! regulation of proteolysis GO:0030162 50 33 0,000 0,09198976 0,11266052 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,09198976 0,11260056 ! cytokinesis GO:0000910 52 33 0,000 0,09198976 0,11254067 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,09198976 0,11248084 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,0946437 0,11566445 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,0946437 0,11560303 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,0946437 0,11554167 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,0946437 0,11548037 ! feeding behavior GO:0007631 45 34 0,000 0,0946437 0,11541914 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,0946437 0,11535798 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,0946437 0,11529688 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,0946437 0,11523584 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,0946437 0,11517487 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,0946437 0,11511396 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,0946437 0,11505312 ! female gamete generation GO:0007292 43 34 0,000 0,0946437 0,11499234 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,0946437 0,11493163 ! polyol metabolic process GO:0019751 44 34 0,000 0,0946437 0,11487098 ! aerobic respiration GO:0009060 47 34 0,000 0,0946437 0,11481039 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,0946437 0,11474987 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,0946437 0,11468941 ! embryonic organ development GO:0048568 45 34 0,000 0,0946437 0,11462902 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,0946437 0,11456869 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,09729003 0,11771019 ! Notch signaling pathway GO:0007219 56 35 0,000 0,09729003 0,1176483 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,09729003 0,11758648 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,09729003 0,11752472 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,09729003 0,11746303 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,09729003 0,1174014 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,09729003 0,11733983 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,09729003 0,11727833 ! glycogen metabolic process GO:0005977 48 35 0,000 0,09729003 0,1172169 ! pigment metabolic process GO:0042440 61 35 0,000 0,09729003 0,11715553 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,09992877 0,12027011 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,09992877 0,12020721 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,09992877 0,12014437 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,09992877 0,1200816 ! negative regulation of binding GO:0051100 58 36 0,000 0,09992877 0,12001889 ! organic ether metabolic process GO:0018904 46 36 0,000 0,09992877 0,11995625 ! tissue remodeling GO:0048771 62 36 0,000 0,09992877 0,11989368 ! neural tube development GO:0021915 50 36 0,000 0,09992877 0,11983117 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,09992877 0,11976872 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,09992877 0,11970634 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,09992877 0,11964403 ! glucan metabolic process GO:0044042 49 36 0,000 0,09992877 0,11958178 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,10255996 0,12266662 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,10255996 0,12260286 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,10255996 0,12253917 ! learning GO:0007612 67 37 0,000 0,10255996 0,12247555 ! ion transmembrane transport GO:0034220 56 37 0,000 0,10255996 0,12241199 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,10255996 0,1223485 ! regulation of protein secretion GO:0050708 51 37 0,000 0,10255996 0,12228507 ! amino acid activation GO:0043038 52 37 0,000 0,10255996 0,12222171 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,10255996 0,12215842 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,1051836 0,12521857 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,1051836 0,12515379 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,1051836 0,12508908 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,1051836 0,12502443 ! phagocytosis GO:0006909 60 38 0,000 0,1051836 0,12495986 ! pigmentation GO:0043473 74 38 0,000 0,1051836 0,12489534 ! maintenance of location in cell GO:0051651 69 38 0,000 0,1051836 0,1248309 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,10779972 0,12786971 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,10779972 0,12780379 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,10779972 0,12773795 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,10779972 0,12767217 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,10779972 0,12760646 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,10779972 0,12754082 ! male sex differentiation GO:0046661 53 39 0,000 0,10779972 0,12747525 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,10779972 0,12740974 ! chromatin remodeling GO:0006338 68 39 0,000 0,10779972 0,1273443 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,10779972 0,12727893 ! JNK cascade GO:0007254 54 39 0,000 0,10779972 0,12721363 ! developmental growth GO:0048589 62 39 0,000 0,10779972 0,12714839 ! cell growth GO:0016049 61 39 0,000 0,10779972 0,12708322 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,11040835 0,1300918 ! response to calcium ion GO:0051592 58 40 0,000 0,11040835 0,13002519 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,11040835 0,12995865 ! regulation of tube size GO:0035150 60 40 0,000 0,11040835 0,12989217 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,11040835 0,12982576 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,11040835 0,12975942 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,11040835 0,12969315 ! peptide metabolic process GO:0006518 56 40 0,000 0,11040835 0,12962695 ! inner ear development GO:0048839 57 40 0,000 0,11040835 0,12956081 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,11040835 0,12949474 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,11040835 0,12942874 ! double-strand break repair GO:0006302 67 40 0,000 0,11040835 0,12936281 ! B cell differentiation GO:0030183 62 40 0,000 0,11040835 0,12929694 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,11040835 0,12923114 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,11040835 0,12916541 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,11300949 0,13214124 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,11300949 0,1320741 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,11300949 0,13200702 ! glucose transport GO:0015758 52 41 0,000 0,11300949 0,13194001 ! endosome transport GO:0016197 71 41 0,000 0,11300949 0,13187307 ! striated muscle contraction GO:0006941 62 41 0,000 0,11300949 0,1318062 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,11300949 0,1317394 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,11300949 0,13167266 ! biopolymer methylation GO:0043414 62 41 0,000 0,11300949 0,13160599 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,11300949 0,13153939 ! mitochondrial transport GO:0006839 60 42 0,000 0,11560318 0,13449029 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,11560318 0,1344223 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,11560318 0,13435438 ! cellular component disassembly GO:0022411 64 42 0,000 0,11560318 0,13428652 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,11560318 0,13421873 ! hexose transport GO:0008645 54 42 0,000 0,11560318 0,13415101 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,11560318 0,13408336 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,11560318 0,13401578 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,11560318 0,13394827 ! excretion GO:0007588 63 42 0,000 0,11560318 0,13388082 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,11560318 0,13381344 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,11560318 0,13374613 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,11560318 0,13367889 ! regulation of cell shape GO:0008360 78 42 0,000 0,11560318 0,13361171 ! positive regulation of binding GO:0051099 59 43 0,000 0,11818943 0,13653224 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,11818943 0,1364637 ! leukocyte migration GO:0050900 60 43 0,000 0,11818943 0,13639523 ! activation of caspase activity GO:0006919 65 43 0,000 0,11818943 0,13632683 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,11818943 0,13625849 ! tRNA processing GO:0008033 49 43 0,000 0,11818943 0,13619023 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,11818943 0,13612203 ! vesicle organization GO:0016050 79 43 0,000 0,11818943 0,1360539 ! response to insulin stimulus GO:0032868 63 43 0,000 0,11818943 0,13598584 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,11818943 0,13591785 ! methylation GO:0032259 64 43 0,000 0,11818943 0,13584992 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,12076827 0,13874476 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,12076827 0,13867549 ! glycolysis GO:0006096 53 44 0,000 0,12076827 0,1386063 ! regulation of ion transport GO:0043269 57 44 0,000 0,12076827 0,13853717 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,12076827 0,1384681 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,12076827 0,13839911 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,12076827 0,13833019 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,12076827 0,13826133 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,12076827 0,13819255 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,12076827 0,13812383 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,12076827 0,13805518 ! positive regulation of defense response GO:0031349 59 45 0,000 0,12333971 0,14092466 ! regulation of translational initiation GO:0006446 64 45 0,000 0,12333971 0,14085468 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,12333971 0,14078478 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,12333971 0,14071495 ! cell maturation GO:0048469 60 45 0,000 0,12333971 0,14064518 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,12590378 0,14349787 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,12590378 0,14342679 ! cell redox homeostasis GO:0045454 63 46 0,000 0,12590378 0,14335579 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,12590378 0,14328486 ! regulation of ossification GO:0030278 71 46 0,000 0,12590378 0,14321399 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,12590378 0,1431432 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,1284605 0,14597784 ! viral infectious cycle GO:0019058 71 47 0,000 0,1284605 0,14590575 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,1284605 0,14583373 ! endocrine system development GO:0035270 83 47 0,000 0,1284605 0,14576179 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,1284605 0,14568991 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,1284605 0,14561811 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,1284605 0,14554638 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,1284605 0,14547471 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,1284605 0,14540312 ! chloride transport GO:0006821 67 48 0,000 0,13100988 0,1482158 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,13100988 0,14814293 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,13100988 0,14807014 ! response to temperature stimulus GO:0009266 62 48 0,000 0,13100988 0,14799741 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,13100988 0,14792475 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,13100988 0,14785217 ! gastrulation GO:0007369 73 48 0,000 0,13100988 0,14777966 ! heart morphogenesis GO:0003007 65 48 0,000 0,13100988 0,14770722 ! regulation of DNA replication GO:0006275 75 48 0,000 0,13100988 0,14763485 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,13100988 0,14756255 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,13100988 0,14749032 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,13100988 0,14741816 ! regulation of endocytosis GO:0030100 63 48 0,000 0,13100988 0,14734608 ! nuclear export GO:0051168 69 48 0,000 0,13100988 0,14727406 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,13100988 0,14720211 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,13355195 0,1499851 ! sensory perception of smell GO:0007608 61 49 0,000 0,13355195 0,1499119 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,13355195 0,14983878 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,13355195 0,14976572 ! RNA elongation GO:0006354 62 49 0,000 0,13355195 0,14969274 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,13355195 0,14961982 ! germ cell development GO:0007281 68 49 0,000 0,13355195 0,14954698 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,13355195 0,14947421 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,13355195 0,1494015 ! cartilage development GO:0051216 70 49 0,000 0,13355195 0,14932887 ! maintenance of location GO:0051235 84 49 0,000 0,13355195 0,14925631 ! regulation of actin filament length GO:0030832 72 50 0,000 0,13608674 0,15201529 ! ear development GO:0043583 72 50 0,000 0,13608674 0,1519415 ! membrane fusion GO:0006944 80 50 0,000 0,13608674 0,15186778 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,13608674 0,15179413 ! lipid modification GO:0030258 73 50 0,000 0,13608674 0,15172055 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,13608674 0,15164704 ! proton transport GO:0015992 75 50 0,000 0,13608674 0,1515736 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,13608674 0,15150024 ! positive regulation of secretion GO:0051047 71 51 0,000 0,13861425 0,15423936 ! hydrogen transport GO:0006818 77 51 0,000 0,13861425 0,15416478 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,13861425 0,15409027 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,13861425 0,15401583 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,13861425 0,15394146 ! transition metal ion transport GO:0000041 74 52 0,000 0,14113451 0,15666475 ! regulation of cellular component size GO:0032535 74 52 0,000 0,14113451 0,15658918 ! aging GO:0007568 79 52 0,000 0,14113451 0,15651368 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,14113451 0,15643825 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,14113451 0,15636289 ! establishment of organelle localization GO:0051656 85 52 0,000 0,14113451 0,15628761 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,14364754 0,15899391 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,14364754 0,15891743 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,14364754 0,15884103 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,14364754 0,1587647 ! kidney development GO:0001822 90 53 0,000 0,14364754 0,15868844 ! single fertilization GO:0007338 59 53 0,000 0,14364754 0,15861226 ! cell projection assembly GO:0030031 76 53 0,000 0,14364754 0,15853615 ! amino acid transport GO:0006865 84 54 0,000 0,14615336 0,16122433 ! regulation of mitosis GO:0007088 84 54 0,000 0,14615336 0,16114704 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,14615336 0,16106983 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,14615336 0,16099269 ! DNA catabolic process GO:0006308 67 54 0,000 0,14615336 0,16091562 ! detection of external stimulus GO:0009581 66 54 0,000 0,14615336 0,16083863 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,14615336 0,16076171 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,14615336 0,16068486 ! mesoderm development GO:0007498 76 55 0,000 0,14865199 0,16335384 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,14865199 0,16327583 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,14865199 0,16319789 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,15114346 0,16585399 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,15114346 0,1657749 ! carbohydrate transport GO:0008643 74 57 0,000 0,15362777 0,16841939 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,15362777 0,16833915 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,15362777 0,16825899 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,15362777 0,16817891 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,15362777 0,1680989 ! camera-type eye development GO:0043010 88 57 0,000 0,15362777 0,16801896 ! secondary metabolic process GO:0019748 84 57 0,000 0,15362777 0,16793911 ! response to peptide hormone stimulus GO:0043434 84 57 0,000 0,15362777 0,16785933 ! developmental maturation GO:0021700 75 57 0,000 0,15362777 0,16777962 ! gonad development GO:0008406 79 57 0,000 0,15362777 0,16769999 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,15610496 0,17032325 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,15610496 0,17024249 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,15857504 0,17285431 ! activation of MAPK activity GO:0000187 84 59 0,000 0,15857504 0,17277243 ! lung development GO:0030324 94 59 0,000 0,15857504 0,17269062 ! actin filament organization GO:0007015 95 59 0,000 0,15857504 0,17260889 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,15857504 0,17252724 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,15857504 0,17244567 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,16103803 0,17504134 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,16103803 0,17495865 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,16103803 0,17487605 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,16103803 0,17479352 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,16103803 0,17471107 ! regulation of heart contraction GO:0008016 91 60 0,000 0,16103803 0,1746287 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,16103803 0,1745464 ! fertilization GO:0009566 68 60 0,000 0,16103803 0,17446419 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,16103803 0,17438205 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,16349395 0,17695816 ! meiosis GO:0007126 96 61 0,000 0,16349395 0,17687492 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,16349395 0,17679177 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,16349395 0,17670869 ! urogenital system development GO:0001655 101 61 0,000 0,16349395 0,17662569 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,16349395 0,17654276 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,16349395 0,17645992 ! extracellular matrix organization GO:0030198 103 61 0,000 0,16349395 0,17637715 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,16349395 0,17629446 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,16349395 0,17621185 ! amine catabolic process GO:0009310 90 62 0,000 0,16594282 0,17876744 ! neurotransmitter transport GO:0006836 81 62 0,000 0,16594282 0,17868375 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,16594282 0,17860014 ! respiratory tube development GO:0030323 99 62 0,000 0,16594282 0,1785166 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,16594282 0,17843314 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,16594282 0,17834976 ! meiotic cell cycle GO:0051321 97 62 0,000 0,16594282 0,17826646 ! organelle localization GO:0051640 96 62 0,000 0,16594282 0,17818324 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,16838467 0,18072083 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,16838467 0,18063654 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,1708195 0,1831631 ! appendage morphogenesis GO:0035107 93 64 0,000 0,1708195 0,18307775 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,1708195 0,18299248 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,1708195 0,18290729 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,1708195 0,18282217 ! hexose catabolic process GO:0019320 82 64 0,000 0,1708195 0,18273714 ! respiratory system development GO:0060541 100 64 0,000 0,1708195 0,18265219 ! adaptive immune response GO:0002250 94 64 0,000 0,1708195 0,18256731 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,17324735 0,18507613 ! appendage development GO:0048736 94 65 0,000 0,17324735 0,1849902 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,17324735 0,18490436 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,17324735 0,1848186 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,17324735 0,18473291 ! defense response to bacterium GO:0042742 73 65 0,000 0,17324735 0,18464731 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,17324735 0,18456179 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,17324735 0,18447634 ! activation of immune response GO:0002253 83 65 0,000 0,17324735 0,18439098 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,17566822 0,18688109 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,17566822 0,18679469 ! antigen processing and presentation GO:0019882 96 66 0,000 0,17566822 0,18670837 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,17566822 0,18662213 ! regulation of immune effector process GO:0002697 101 66 0,000 0,17566822 0,18653597 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,17808215 0,18901197 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,17808215 0,18892479 ! acute inflammatory response GO:0002526 92 68 0,000 0,18048914 0,19139005 ! learning or memory GO:0007611 123 68 0,000 0,18048914 0,19130186 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,18048914 0,19121374 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,18048914 0,1911257 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,18048914 0,19103775 ! rhythmic process GO:0048511 105 68 0,000 0,18048914 0,19094987 ! inorganic anion transport GO:0015698 93 68 0,000 0,18048914 0,19086208 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,18288923 0,19331122 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,18288923 0,19322242 ! response to drug GO:0042493 108 69 0,000 0,18288923 0,19313371 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,18288923 0,19304507 ! response to metal ion GO:0010038 103 70 0,000 0,18528242 0,19548145 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,18528242 0,19539182 ! humoral immune response GO:0006959 86 70 0,000 0,18528242 0,19530227 ! eye development GO:0001654 111 70 0,000 0,18528242 0,19521281 ! amine transport GO:0015837 101 70 0,000 0,18528242 0,19512342 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,18528242 0,19503412 ! regulation of catabolic process GO:0009894 106 70 0,000 0,18528242 0,1949449 ! muscle cell differentiation GO:0042692 104 71 0,000 0,18766874 0,19736538 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,18766874 0,19727518 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,18766874 0,19718506 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,18766874 0,19709502 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,18766874 0,19700506 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,18766874 0,19691519 ! response to hypoxia GO:0001666 132 72 0,000 0,1900482 0,19932096 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,1900482 0,19923011 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,1900482 0,19913935 ! negative regulation of transport GO:0051051 116 73 0,000 0,19242084 0,20153366 ! regulation of blood pressure GO:0008217 107 73 0,000 0,19242084 0,20144193 ! tube morphogenesis GO:0035239 118 73 0,000 0,19242084 0,20135028 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,19242084 0,20125872 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,19242084 0,20116724 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,19478666 0,20354807 ! response to oxygen levels GO:0070482 137 74 0,000 0,19478666 0,20345563 ! digestion GO:0007586 97 74 0,000 0,19478666 0,20336328 ! protein import into nucleus GO:0006606 118 74 0,000 0,19478666 0,20327101 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,19478666 0,20317882 ! blood coagulation GO:0007596 116 75 0,000 0,19714568 0,20554627 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,19714568 0,20545313 ! response to nutrient GO:0007584 104 75 0,000 0,19714568 0,20536008 ! regulation of ligase activity GO:0051340 114 75 0,000 0,19714568 0,20526712 ! nuclear import GO:0051170 121 75 0,000 0,19714568 0,20517424 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,19714568 0,20508144 ! amine biosynthetic process GO:0009309 97 76 0,000 0,19949793 0,20743455 ! tRNA metabolic process GO:0006399 95 76 0,000 0,19949793 0,20734082 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,19949793 0,20724717 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,20184342 0,2095891 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,20184342 0,20949452 ! regulation of DNA binding GO:0051101 119 77 0,000 0,20184342 0,20940003 ! sex differentiation GO:0007548 105 77 0,000 0,20184342 0,20930562 ! protein ubiquitination GO:0016567 125 77 0,000 0,20184342 0,20921129 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,20184342 0,20911705 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,20184342 0,2090229 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,20184342 0,20892883 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,20418217 0,21125461 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,20418217 0,21115962 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,20418217 0,21106471 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,2065142 0,21337945 ! cellular respiration GO:0045333 107 79 0,000 0,2065142 0,21328364 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,2065142 0,21318791 ! T cell activation GO:0042110 134 79 0,000 0,2065142 0,21309227 ! regulation of lyase activity GO:0051339 133 79 0,000 0,2065142 0,21299671 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,2065142 0,21290124 ! chromatin assembly GO:0031497 102 80 0,000 0,20883954 0,21520203 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,20883954 0,21510566 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,20883954 0,21500937 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,20883954 0,21491317 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,20883954 0,21481705 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,21115819 0,21710498 ! hemostasis GO:0007599 125 81 0,000 0,21115819 0,21700797 ! mRNA transport GO:0051028 121 81 0,000 0,21115819 0,21691105 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,21115819 0,21681421 ! vitamin metabolic process GO:0006766 103 81 0,000 0,21115819 0,21671746 ! detection of stimulus GO:0051606 108 82 0,000 0,21347018 0,2189926 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,21577552 0,2212589 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,21577552 0,2211603 ! regulation of defense response GO:0031347 117 84 0,000 0,21807424 0,22341682 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,21807424 0,22331735 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,21807424 0,22321796 ! sterol metabolic process GO:0016125 120 84 0,000 0,21807424 0,22311867 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,22036636 0,22536355 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,22036636 0,22526339 ! rRNA metabolic process GO:0016072 107 85 0,000 0,22036636 0,22516332 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,22036636 0,22506333 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,22036636 0,22496344 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,22265189 0,2271958 ! nucleosome organization GO:0034728 114 87 0,000 0,22493084 0,22941949 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,22493084 0,22931779 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,22493084 0,22921619 ! female pregnancy GO:0007565 130 87 0,000 0,22493084 0,22911468 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,22720325 0,23132691 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,22720325 0,23122455 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,22720325 0,23112228 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,22720325 0,23102011 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,22720325 0,23091802 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,22946913 0,23311793 ! reproductive developmental process GO:0003006 127 89 0,000 0,22946913 0,23301501 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,22946913 0,23291218 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,22946913 0,23280944 ! leukocyte differentiation GO:0002521 143 90 0,000 0,23172849 0,23499803 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,23172849 0,23489446 ! hormone metabolic process GO:0042445 121 90 0,000 0,23172849 0,23479098 ! RNA localization GO:0006403 135 91 0,000 0,23398135 0,23696923 ! ATP metabolic process GO:0046034 137 91 0,000 0,23398135 0,23686493 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,23622774 0,23903379 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,23622774 0,23892868 ! cell fate commitment GO:0045165 141 92 0,000 0,23622774 0,23882365 ! positive regulation of immune response GO:0050778 121 92 0,000 0,23622774 0,23871872 ! DNA recombination GO:0006310 146 92 0,000 0,23622774 0,23861388 ! sulfur metabolic process GO:0006790 118 92 0,000 0,23622774 0,23850914 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,23846767 0,24066505 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,23846767 0,2405595 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,23846767 0,24045403 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,23846767 0,24034866 ! electron transport chain GO:0022900 123 94 0,000 0,24070116 0,24249351 ! regulation of binding GO:0051098 151 95 0,000 0,24292823 0,24463 ! angiogenesis GO:0001525 149 95 0,000 0,24292823 0,24452295 ! carboxylic acid transport GO:0046942 147 95 0,000 0,24292823 0,24441598 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,24514889 0,24654239 ! in utero embryonic development GO:0001701 147 96 0,000 0,24514889 0,24643464 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,24514889 0,24632698 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,24514889 0,24621941 ! protein maturation GO:0051604 129 96 0,000 0,24514889 0,24611194 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,24736317 0,24822657 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,24736317 0,24811831 ! protein import GO:0017038 156 99 0,000 0,25177263 0,25243115 ! regulation of translation GO:0006417 151 100 0,000 0,25396786 0,25452117 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,25396786 0,25441031 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,25396786 0,25429955 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,25396786 0,25418889 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,25396786 0,25407833 ! protein localization in organelle GO:0033365 161 100 0,000 0,25396786 0,25396786